id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278641-8lh5y7j0	Chen, Jianing	Identification and characterization of PEDV infection in rat crypt epithelial cells	2020-09-17		.txt	text/plain	2774	182	63	Porcine epidemic diarrhea virus (PEDV), as the PED causative agent, has been commonly propagated and investigated in Vero cells, as well as in IPEC-J2, a porcine epithelial cell-jejunum 2. Besides that, PEDV infection in IEC-6 cells can induce the production of inflammatory cytokines and interferon, especially the type III IFNs. Collectively, our findings suggest that IEC-6 is an ideal cell line for PEDV replication and immune response studies. PEDV CV777 strain reached its most elevated viral titers in both Vero and IEC-6 cells but poorly replicated in IPEC-J2 cells (Fig. 1E) . The results showed that both type I and type III interferon responses were significantly activated in PEDV infected IEC-6 and IPEC-J2 cells while the type I interferon were absent in Vero cells ( Fig. 2A, 2B, 2D, 2E ). For type II interferon, PEDV infection led to a significant upregulation in IEC-6 cells but not in IPEC-J2 and Vero cells (Fig. 2C) .	./cache/cord-278641-8lh5y7j0.txt	./txt/cord-278641-8lh5y7j0.txt