id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258433-n50joeda	Chang, Long	β-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection	2020-08-08		.txt	text/plain	4964	242	50	Interestingly, β-catenin was found to be involved in the regulation of c-Jun signaling in virus-infected cells as iCRT14, a β-catenin-specific inhibitor that can inhibit β-catenin-dependent transcriptional activity, was able to decrease protein expression and phosphorylation of c-Jun. Furthermore, we suggest that BoHV-1 infection stimulates c-Jun phosphorylation regulated by β-catenin via both c-Jun NH2-terminal kinase (JNK)-dependent and JNK-independent mechanisms. Similarly, BoHV-1 infection activates the JNK/c-Jun cascade, with inhibition of this pathway via the chemical inhibitor SP600125 significantly blocking productive infection in cell cultures (Zhu et al., 2016) . In order to understand the effects that β-catenin had on the activation of c-Jun signaling stimulated by BoHV-1 infection, we detected the protein levels of both c-Jun and p-c-Jun(S73) in the presence of β-catenin-specific inhibitor iCRT14 via Western blot. Taken together, these data suggest that in BoHV-1-infected MDBK cells, β-catenin is potentially involved in the phosphorylation of c-Jun signaling partially through the activation of JNK.	./cache/cord-258433-n50joeda.txt	./txt/cord-258433-n50joeda.txt