id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325998-87l6nixc	Wong, J.P.	Activation of toll-like receptor signaling pathway for protection against influenza virus infection	2009-05-26		.txt	text/plain	2215	121	53	This study aims to evaluate the antiviral role of nucleic acid-based agonists for the activation of toll-like receptor (TLR) signaling pathways, and its protective role in respiratory influenza A virus infections. Intranasal pre-treatment of mice with Poly ICLC and LE Poly ICLC provided high level of protection against lethal challenge with a highly lethal avian H5N1 influenza (HPAI) strain (A/H5N1/chicken/Henan clade 2), and against lethal seasonal influenza A/PR/8/34 [H1N1] and A/Aichi/2 [H3N2] virus strains. Since TLR-3 activation by ds RNA results in induction of type I interferons, it follows that Poly ICLC, when delivered in liposomes to the endosomal membrane location, may strengthen the host antiviral defence against influenza virus by priming the interferon levels and, therefore, reversing the interferon knockdown by the viruses. The effect of poly ICLC and LE Poly ICLC on the TLR-3 expression in the lungs of mice intranasally pre-treated with these drugs were determined by RT-PCR (Fig. 1) .	./cache/cord-325998-87l6nixc.txt	./txt/cord-325998-87l6nixc.txt