id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322505-6q92742u	Basinski, Andrew J.	Evaluating the promise of recombinant transmissible vaccines	2017-12-24		.txt	text/plain	4188	174	39	We build a mathematical model to test whether a RTV can facilitate disease management in instances where reversion is likely to introduce the vector into the population or when the vector organism is already established in the host population, and the vector and vaccine share perfect cross-immunity. If cross-immunity between vaccine and vector exists, however, our results show that a RTV can substantially reduce the vaccination effort necessary to control or eradicate a pathogen only when continuously augmented with direct manual vaccination. Thus, if the vector organism has reached endemic levels in the population, has a larger R 0 than the pathogen, and imparts vaccine cross-immunity, the use of a RTV reduces the rate of direct vaccination required for prophylactic protection from a pathogen by a factor (4) Eq. Alternatively, if the vector organism is already circulating within the host population and vector infection imparts perfect vaccine cross-immunity, the benefits of a RTV are more modest, and require that autonomous vaccination be supplemented with continuous direct vaccination.	./cache/cord-322505-6q92742u.txt	./txt/cord-322505-6q92742u.txt