id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-313911-lfn9ggg3	Kenner, Julie	LC16m8: An attenuated smallpox vaccine	2006-11-17		.txt	text/plain	7952	377	42	LC16m8, an attenuated, replicating smallpox vaccine derived from the Lister strain of vaccinia, is currently licensed in Japan where it was safely used in over 50,000 children in the 1970s. LC16m8 is immunogenic after a single dose, and recent studies in two different animal models have demonstrated protective efficacy equivalent to that of the only FDA-licensed smallpox vaccine. In addition, plaque-purified LC16m8 and a construct of LC16m8 lacking the B5R gene were shown to have safety profiles comparable to that of MVA in the same animal models and to confer protective immunity in a mouse/intranasal vaccinia (Western Reserve [WR] strain) challenge study [47] . Since animal challenge studies were not conducted during the development of LC16m8 in the 1970s, alternative measures of immunity that had been used to characterize other smallpox vaccines [65, 66] were used to evaluate the efficacy of LC16m8 in early clinical trials in Japan.	./cache/cord-313911-lfn9ggg3.txt	./txt/cord-313911-lfn9ggg3.txt