id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279985-de0b27nq	Anraku, Itaru	Kunjin replicon-based simian immunodeficiency virus gag vaccines	2008-06-19		.txt	text/plain	6392	325	53	Kunjin replicon VLP vaccines encoding HIV-1 gag have also been shown to induce CD8 T cell immunity comparable to that seen after immunisation with recombinant vaccinia [11] . Here we describe the behaviour of four different Kunjin replicon VLP vaccines encoding SIV gag and show that only the Gag-pol vaccine (i) induced good levels of both effector memory and central memory T cell responses 10 weeks post-vaccination, comparable to those induced by the previously described HIV-1 gag Kunjin replicon VLP vaccine [11] , (ii) showed good levels of protection against challenge with A20 cells expressing SIV Gag ≈9 months post-vaccination, and (iii) displayed high levels of insert stability. In summary we describe here a Kunjin replicon SIV Gag-pol VLP vaccine, which showed high insert stability, good induction of effector and central memory responses, and good protection against a model challenge.	./cache/cord-279985-de0b27nq.txt	./txt/cord-279985-de0b27nq.txt