id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277355-si3g5dih	He, Yu	The role of capsid in the flaviviral life cycle and perspectives for vaccine development	2020-09-17		.txt	text/plain	6885	319	45	Although current studies on flaviviruses have shown that the flaviviral assembly process does not exhibit a necessary step occurring in the cell nucleus, it has been well demonstrated that many mosquito-borne flavivirus CPs partially localize in the cell nucleus [44] [45] [46] [47] [48] ; in the cytoplasm, in addition to localizing in the ER, DENV CP and ZIKV CP have also been demonstrated to accumulate on LDs [13, 16] , but the link between the functional importance and the subcellular distribution of CPs is still unclear. Interestingly, a study showed that a CD61-71 mutant had abolished ZIKV infectious virion production that was then restored by adaptive mutations (prM-E21K and NS2B-E27G) only in BHK21 cells but not in other cell lines (indicate complex interactions that apparently occur between structural and non-structural proteins during virus replication and/or assembly), making this live virus function like a single-round infectious particle (SRIP) in vivo and safely inducing strong immunity protection against vertical transmission in mice [33] .	./cache/cord-277355-si3g5dih.txt	./txt/cord-277355-si3g5dih.txt