id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276209-5999g9gp	Poland, Gregory A.	Tortoises, hares, and vaccines: A cautionary note for SARS-CoV-2 vaccine development	2020-06-02		.txt	text/plain	1607	105	55	Very soon thereafter, the causative agent was identified as the now-named SARS-CoV-2 virus-a betacoronavirus that had crossed the species barrier to infect humans. There is no question that a vaccine against this virus, and other as-yet-to-come coronaviruses, is imperative to protect human health and to quickly respond to future viral introductions, epidemics, and pandemics. These pathways, informed by science and the past history of successes and failures, are designed to maximize the chances of efficacy and safety. Further mutations could conceivably lead to issues of original antigenic sin with resultant disease enhancement after exposure or to vaccines that simply are not effective into the future. In addition to safety issues, I raise concern over ''S-only" vaccine approaches for the mid-to long-term control of this RNA virus. We need a vaccine-and we need it as quickly as one can be developed-that demonstrates safety and efficacy in adequately powered studies.	./cache/cord-276209-5999g9gp.txt	./txt/cord-276209-5999g9gp.txt