id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260761-ngms51ie	Sawada, Akihito	AIK-C measles vaccine expressing fusion protein of respiratory syncytial virus induces protective antibodies in cotton rats	2011-02-04		.txt	text/plain	6575	321	51	title: AIK-C measles vaccine expressing fusion protein of respiratory syncytial virus induces protective antibodies in cotton rats When cotton rats immunized with MVAIK/RSV/G were challenged with RSV subgroup A, low levels of infectious virus were recovered from lung. Reverse genetics of the AIK-C live attenuated vaccine was performed and in this study, recombinant AIK-C MV vaccine strains encoding the RSV G or F protein were constructed, and immunogenicity and protective effects against RSV were investigated in cotton rats immunized with recombinant measles vaccines, expressing RSV G or F protein. Cotton rats were sacrificed 10 days after immunization with MVAIK/RSV/G and F, and samples of liver, kidney, spleen, lung, thymus, and nasal turbinate were obtained to detect the MV genome. The recombinant measles virus (MVAIK) triggered an immune response three weeks after vaccination in cotton rats. In non-immunized cotton rats, 10 5.4 and 10 4.5 PFU of infectious virus were recovered from 20 mg of lung tissue four days after the RSV challenge.	./cache/cord-260761-ngms51ie.txt	./txt/cord-260761-ngms51ie.txt