id sid tid token lemma pos cord-339444-f8lfob47 1 1 key key NNP cord-339444-f8lfob47 1 2 : : : cord-339444-f8lfob47 1 3 cord-339444-f8lfob47 cord-339444-f8lfob47 NN cord-339444-f8lfob47 1 4 authors author NNS cord-339444-f8lfob47 1 5 : : : cord-339444-f8lfob47 1 6 Bigna Bigna NNP cord-339444-f8lfob47 1 7 , , , cord-339444-f8lfob47 1 8 Jean Jean NNP cord-339444-f8lfob47 1 9 Joel Joel NNP cord-339444-f8lfob47 1 10 ; ; : cord-339444-f8lfob47 1 11 Kamtchum Kamtchum NNP cord-339444-f8lfob47 1 12 - - HYPH cord-339444-f8lfob47 1 13 Tatuene Tatuene NNP cord-339444-f8lfob47 1 14 , , , cord-339444-f8lfob47 1 15 Joseph Joseph NNP cord-339444-f8lfob47 1 16 ; ; : cord-339444-f8lfob47 1 17 Noubiap Noubiap NNP cord-339444-f8lfob47 1 18 , , , cord-339444-f8lfob47 1 19 Jean Jean NNP cord-339444-f8lfob47 1 20 Jacques Jacques NNP cord-339444-f8lfob47 1 21 title title NN cord-339444-f8lfob47 1 22 : : : cord-339444-f8lfob47 1 23 Claims claim NNS cord-339444-f8lfob47 1 24 about about IN cord-339444-f8lfob47 1 25 the the DT cord-339444-f8lfob47 1 26 safety safety NN cord-339444-f8lfob47 1 27 and and CC cord-339444-f8lfob47 1 28 efficacy efficacy NN cord-339444-f8lfob47 1 29 of of IN cord-339444-f8lfob47 1 30 early early JJ cord-339444-f8lfob47 1 31 treatment treatment NN cord-339444-f8lfob47 1 32 of of IN cord-339444-f8lfob47 1 33 COVID-19 COVID-19 NNP cord-339444-f8lfob47 1 34 with with IN cord-339444-f8lfob47 1 35 hydroxychloroquine hydroxychloroquine NNP cord-339444-f8lfob47 1 36 and and CC cord-339444-f8lfob47 1 37 azithromycin azithromycin NNP cord-339444-f8lfob47 1 38 must must MD cord-339444-f8lfob47 1 39 be be VB cord-339444-f8lfob47 1 40 supported support VBN cord-339444-f8lfob47 1 41 by by IN cord-339444-f8lfob47 1 42 real real JJ cord-339444-f8lfob47 1 43 evidence evidence NN cord-339444-f8lfob47 1 44 date date NN cord-339444-f8lfob47 1 45 : : : cord-339444-f8lfob47 1 46 2020 2020 CD cord-339444-f8lfob47 1 47 - - HYPH cord-339444-f8lfob47 1 48 09 09 CD cord-339444-f8lfob47 1 49 - - SYM cord-339444-f8lfob47 1 50 25 25 CD cord-339444-f8lfob47 1 51 journal journal NN cord-339444-f8lfob47 1 52 : : : cord-339444-f8lfob47 2 1 Travel travel VB cord-339444-f8lfob47 2 2 Med Med NNP cord-339444-f8lfob47 2 3 Infect infect VBP cord-339444-f8lfob47 2 4 Dis dis NN cord-339444-f8lfob47 2 5 DOI doi NN cord-339444-f8lfob47 2 6 : : : cord-339444-f8lfob47 2 7 10.1016/ 10.1016/ CD cord-339444-f8lfob47 3 1 j.tmaid.2020.101886 j.tmaid.2020.101886 NNP cord-339444-f8lfob47 3 2 sha sha NNP cord-339444-f8lfob47 3 3 : : : cord-339444-f8lfob47 4 1 c5cd5cd6e3d714e38d92731867aa0c8903dc6ad1 c5cd5cd6e3d714e38d92731867aa0c8903dc6ad1 NNP cord-339444-f8lfob47 4 2 doc_id doc_id CD cord-339444-f8lfob47 4 3 : : : cord-339444-f8lfob47 4 4 339444 339444 CD cord-339444-f8lfob47 4 5 cord_uid cord_uid NNS cord-339444-f8lfob47 4 6 : : : cord-339444-f8lfob47 5 1 f8lfob47 f8lfob47 NNP cord-339444-f8lfob47 5 2 nan nan NNP cord-339444-f8lfob47 6 1 Based base VBN cord-339444-f8lfob47 6 2 on on IN cord-339444-f8lfob47 6 3 data datum NNS cord-339444-f8lfob47 6 4 from from IN cord-339444-f8lfob47 6 5 1061 1061 CD cord-339444-f8lfob47 6 6 COVID-19 covid-19 CD cord-339444-f8lfob47 6 7 patients patient NNS cord-339444-f8lfob47 6 8 ( ( -LRB- cord-339444-f8lfob47 6 9 94.7 94.7 CD cord-339444-f8lfob47 6 10 % % NN cord-339444-f8lfob47 6 11 symptomatic symptomatic JJ cord-339444-f8lfob47 6 12 , , , cord-339444-f8lfob47 6 13 85.7 85.7 CD cord-339444-f8lfob47 6 14 % % NN cord-339444-f8lfob47 6 15 outpatients outpatient NNS cord-339444-f8lfob47 6 16 ) ) -RRB- cord-339444-f8lfob47 6 17 , , , cord-339444-f8lfob47 6 18 the the DT cord-339444-f8lfob47 6 19 authors author NNS cord-339444-f8lfob47 6 20 concluded conclude VBD cord-339444-f8lfob47 6 21 that that IN cord-339444-f8lfob47 6 22 early early JJ cord-339444-f8lfob47 6 23 treatment treatment NN cord-339444-f8lfob47 6 24 of of IN cord-339444-f8lfob47 6 25 COVID-19 COVID-19 NNP cord-339444-f8lfob47 6 26 ( ( -LRB- cord-339444-f8lfob47 6 27 before before IN cord-339444-f8lfob47 6 28 complications complication NNS cord-339444-f8lfob47 6 29 occur occur VBP cord-339444-f8lfob47 6 30 ) ) -RRB- cord-339444-f8lfob47 6 31 with with IN cord-339444-f8lfob47 6 32 the the DT cord-339444-f8lfob47 6 33 combination combination NN cord-339444-f8lfob47 6 34 of of IN cord-339444-f8lfob47 6 35 hydroxychloroquine hydroxychloroquine NN cord-339444-f8lfob47 6 36 and and CC cord-339444-f8lfob47 6 37 azithromycin azithromycin NNP cord-339444-f8lfob47 6 38 ( ( -LRB- cord-339444-f8lfob47 6 39 HCQ+AZ HCQ+AZ NNP cord-339444-f8lfob47 6 40 ) ) -RRB- cord-339444-f8lfob47 6 41 " " `` cord-339444-f8lfob47 6 42 is be VBZ cord-339444-f8lfob47 6 43 safe safe JJ cord-339444-f8lfob47 6 44 and and CC cord-339444-f8lfob47 6 45 associated associate VBN cord-339444-f8lfob47 6 46 with with IN cord-339444-f8lfob47 6 47 very very RB cord-339444-f8lfob47 6 48 low low JJ cord-339444-f8lfob47 6 49 fatality fatality NN cord-339444-f8lfob47 6 50 rate rate NN cord-339444-f8lfob47 6 51 " " '' cord-339444-f8lfob47 6 52 [ [ -LRB- cord-339444-f8lfob47 6 53 1 1 CD cord-339444-f8lfob47 6 54 ] ] -RRB- cord-339444-f8lfob47 6 55 . . . cord-339444-f8lfob47 7 1 This this DT cord-339444-f8lfob47 7 2 claim claim NN cord-339444-f8lfob47 7 3 is be VBZ cord-339444-f8lfob47 7 4 not not RB cord-339444-f8lfob47 7 5 supported support VBN cord-339444-f8lfob47 7 6 by by IN cord-339444-f8lfob47 7 7 the the DT cord-339444-f8lfob47 7 8 data datum NNS cord-339444-f8lfob47 7 9 presented present VBN cord-339444-f8lfob47 7 10 in in IN cord-339444-f8lfob47 7 11 their -PRON- PRP$ cord-339444-f8lfob47 7 12 article article NN cord-339444-f8lfob47 7 13 and and CC cord-339444-f8lfob47 7 14 is be VBZ cord-339444-f8lfob47 7 15 , , , cord-339444-f8lfob47 7 16 therefore therefore RB cord-339444-f8lfob47 7 17 , , , cord-339444-f8lfob47 7 18 misleading mislead VBG cord-339444-f8lfob47 7 19 . . . cord-339444-f8lfob47 8 1 Indeed indeed RB cord-339444-f8lfob47 8 2 , , , cord-339444-f8lfob47 8 3 in in IN cord-339444-f8lfob47 8 4 the the DT cord-339444-f8lfob47 8 5 absence absence NN cord-339444-f8lfob47 8 6 of of IN cord-339444-f8lfob47 8 7 a a DT cord-339444-f8lfob47 8 8 control control NN cord-339444-f8lfob47 8 9 group group NN cord-339444-f8lfob47 8 10 of of IN cord-339444-f8lfob47 8 11 patients patient NNS cord-339444-f8lfob47 8 12 who who WP cord-339444-f8lfob47 8 13 did do VBD cord-339444-f8lfob47 8 14 not not RB cord-339444-f8lfob47 8 15 receive receive VB cord-339444-f8lfob47 8 16 HCQ+AZ HCQ+AZ NNP cord-339444-f8lfob47 8 17 , , , cord-339444-f8lfob47 8 18 it -PRON- PRP cord-339444-f8lfob47 8 19 is be VBZ cord-339444-f8lfob47 8 20 inappropriate inappropriate JJ cord-339444-f8lfob47 8 21 to to TO cord-339444-f8lfob47 8 22 conclude conclude VB cord-339444-f8lfob47 8 23 that that IN cord-339444-f8lfob47 8 24 this this DT cord-339444-f8lfob47 8 25 therapeutic therapeutic JJ cord-339444-f8lfob47 8 26 combination combination NN cord-339444-f8lfob47 8 27 was be VBD cord-339444-f8lfob47 8 28 associated associate VBN cord-339444-f8lfob47 8 29 with with IN cord-339444-f8lfob47 8 30 low low JJ cord-339444-f8lfob47 8 31 fatality fatality NN cord-339444-f8lfob47 8 32 rate rate NN cord-339444-f8lfob47 8 33 . . . cord-339444-f8lfob47 9 1 This this DT cord-339444-f8lfob47 9 2 is be VBZ cord-339444-f8lfob47 9 3 a a DT cord-339444-f8lfob47 9 4 major major JJ cord-339444-f8lfob47 9 5 concern concern NN cord-339444-f8lfob47 9 6 , , , cord-339444-f8lfob47 9 7 especially especially RB cord-339444-f8lfob47 9 8 because because IN cord-339444-f8lfob47 9 9 spontaneous spontaneous JJ cord-339444-f8lfob47 9 10 clearance clearance NN cord-339444-f8lfob47 9 11 of of IN cord-339444-f8lfob47 9 12 SARS SARS NNP cord-339444-f8lfob47 9 13 - - HYPH cord-339444-f8lfob47 9 14 CoV-2 CoV-2 NNP cord-339444-f8lfob47 9 15 infection infection NN cord-339444-f8lfob47 9 16 is be VBZ cord-339444-f8lfob47 9 17 more more RBR cord-339444-f8lfob47 9 18 common common JJ cord-339444-f8lfob47 9 19 in in IN cord-339444-f8lfob47 9 20 younger young JJR cord-339444-f8lfob47 9 21 individuals individual NNS cord-339444-f8lfob47 9 22 who who WP cord-339444-f8lfob47 9 23 seem seem VBP cord-339444-f8lfob47 9 24 to to TO cord-339444-f8lfob47 9 25 represent represent VB cord-339444-f8lfob47 9 26 the the DT cord-339444-f8lfob47 9 27 majority majority NN cord-339444-f8lfob47 9 28 of of IN cord-339444-f8lfob47 9 29 the the DT cord-339444-f8lfob47 9 30 study study NN cord-339444-f8lfob47 9 31 cohort cohort NN cord-339444-f8lfob47 9 32 [ [ -LRB- cord-339444-f8lfob47 9 33 2 2 CD cord-339444-f8lfob47 9 34 ] ] -RRB- cord-339444-f8lfob47 9 35 . . . cord-339444-f8lfob47 10 1 The the DT cord-339444-f8lfob47 10 2 authors author NNS cord-339444-f8lfob47 10 3 do do VBP cord-339444-f8lfob47 10 4 not not RB cord-339444-f8lfob47 10 5 provide provide VB cord-339444-f8lfob47 10 6 a a DT cord-339444-f8lfob47 10 7 rationale rationale NN cord-339444-f8lfob47 10 8 for for IN cord-339444-f8lfob47 10 9 the the DT cord-339444-f8lfob47 10 10 decision decision NN cord-339444-f8lfob47 10 11 not not RB cord-339444-f8lfob47 10 12 to to TO cord-339444-f8lfob47 10 13 consider consider VB cord-339444-f8lfob47 10 14 a a DT cord-339444-f8lfob47 10 15 control control NN cord-339444-f8lfob47 10 16 group group NN cord-339444-f8lfob47 10 17 . . . cord-339444-f8lfob47 11 1 This this DT cord-339444-f8lfob47 11 2 is be VBZ cord-339444-f8lfob47 11 3 a a DT cord-339444-f8lfob47 11 4 fundamental fundamental JJ cord-339444-f8lfob47 11 5 methodological methodological JJ cord-339444-f8lfob47 11 6 point point NN cord-339444-f8lfob47 11 7 that that WDT cord-339444-f8lfob47 11 8 would would MD cord-339444-f8lfob47 11 9 help help VB cord-339444-f8lfob47 11 10 to to TO cord-339444-f8lfob47 11 11 support support VB cord-339444-f8lfob47 11 12 the the DT cord-339444-f8lfob47 11 13 argument argument NN cord-339444-f8lfob47 11 14 for for IN cord-339444-f8lfob47 11 15 a a DT cord-339444-f8lfob47 11 16 causal causal JJ cord-339444-f8lfob47 11 17 link link NN cord-339444-f8lfob47 11 18 between between IN cord-339444-f8lfob47 11 19 early early JJ cord-339444-f8lfob47 11 20 HCQ+AZ HCQ+AZ NNP cord-339444-f8lfob47 11 21 therapy therapy NN cord-339444-f8lfob47 11 22 and and CC cord-339444-f8lfob47 11 23 good good JJ cord-339444-f8lfob47 11 24 clinical clinical JJ cord-339444-f8lfob47 11 25 outcomes outcome NNS cord-339444-f8lfob47 11 26 . . . cord-339444-f8lfob47 12 1 Furthermore furthermore RB cord-339444-f8lfob47 12 2 , , , cord-339444-f8lfob47 12 3 their -PRON- PRP$ cord-339444-f8lfob47 12 4 safety safety NN cord-339444-f8lfob47 12 5 data datum NNS cord-339444-f8lfob47 12 6 are be VBP cord-339444-f8lfob47 12 7 also also RB cord-339444-f8lfob47 12 8 not not RB cord-339444-f8lfob47 12 9 generalizable generalizable JJ cord-339444-f8lfob47 12 10 because because IN cord-339444-f8lfob47 12 11 they -PRON- PRP cord-339444-f8lfob47 12 12 are be VBP cord-339444-f8lfob47 12 13 more more RBR cord-339444-f8lfob47 12 14 likely likely JJ cord-339444-f8lfob47 12 15 to to TO cord-339444-f8lfob47 12 16 be be VB cord-339444-f8lfob47 12 17 driven drive VBN cord-339444-f8lfob47 12 18 by by IN cord-339444-f8lfob47 12 19 the the DT cord-339444-f8lfob47 12 20 specific specific JJ cord-339444-f8lfob47 12 21 demographic demographic JJ cord-339444-f8lfob47 12 22 and and CC cord-339444-f8lfob47 12 23 clinical clinical JJ cord-339444-f8lfob47 12 24 characteristics characteristic NNS cord-339444-f8lfob47 12 25 of of IN cord-339444-f8lfob47 12 26 the the DT cord-339444-f8lfob47 12 27 population population NN cord-339444-f8lfob47 12 28 . . . cord-339444-f8lfob47 13 1 Indeed indeed RB cord-339444-f8lfob47 13 2 , , , cord-339444-f8lfob47 13 3 with with IN cord-339444-f8lfob47 13 4 a a DT cord-339444-f8lfob47 13 5 mean mean JJ cord-339444-f8lfob47 13 6 age age NN cord-339444-f8lfob47 13 7 of of IN cord-339444-f8lfob47 13 8 only only RB cord-339444-f8lfob47 13 9 43.6 43.6 CD cord-339444-f8lfob47 13 10 years year NNS cord-339444-f8lfob47 13 11 , , , cord-339444-f8lfob47 13 12 the the DT cord-339444-f8lfob47 13 13 study study NN cord-339444-f8lfob47 13 14 population population NN cord-339444-f8lfob47 13 15 likely likely RB cord-339444-f8lfob47 13 16 represents represent VBZ cord-339444-f8lfob47 13 17 a a DT cord-339444-f8lfob47 13 18 selected select VBN cord-339444-f8lfob47 13 19 group group NN cord-339444-f8lfob47 13 20 of of IN cord-339444-f8lfob47 13 21 individuals individual NNS cord-339444-f8lfob47 13 22 with with IN cord-339444-f8lfob47 13 23 low low JJ cord-339444-f8lfob47 13 24 prevalence prevalence NN cord-339444-f8lfob47 13 25 of of IN cord-339444-f8lfob47 13 26 comorbidities comorbiditie NNS cord-339444-f8lfob47 13 27 known know VBN cord-339444-f8lfob47 13 28 to to TO cord-339444-f8lfob47 13 29 favor favor VB cord-339444-f8lfob47 13 30 the the DT cord-339444-f8lfob47 13 31 occurrence occurrence NN cord-339444-f8lfob47 13 32 of of IN cord-339444-f8lfob47 13 33 hydroxychloroquine hydroxychloroquine NN cord-339444-f8lfob47 13 34 - - HYPH cord-339444-f8lfob47 13 35 related relate VBN cord-339444-f8lfob47 13 36 cardiac cardiac JJ cord-339444-f8lfob47 13 37 adverse adverse JJ cord-339444-f8lfob47 13 38 events event NNS cord-339444-f8lfob47 13 39 . . . cord-339444-f8lfob47 14 1 Moreover moreover RB cord-339444-f8lfob47 14 2 , , , cord-339444-f8lfob47 14 3 the the DT cord-339444-f8lfob47 14 4 multivariable multivariable JJ cord-339444-f8lfob47 14 5 model model NN cord-339444-f8lfob47 14 6 used use VBN cord-339444-f8lfob47 14 7 to to TO cord-339444-f8lfob47 14 8 explore explore VB cord-339444-f8lfob47 14 9 factors factor NNS cord-339444-f8lfob47 14 10 associated associate VBN cord-339444-f8lfob47 14 11 with with IN cord-339444-f8lfob47 14 12 poor poor JJ cord-339444-f8lfob47 14 13 outcomes outcome NNS cord-339444-f8lfob47 14 14 in in IN cord-339444-f8lfob47 14 15 this this DT cord-339444-f8lfob47 14 16 study study NN cord-339444-f8lfob47 14 17 presents present VBZ cord-339444-f8lfob47 14 18 some some DT cord-339444-f8lfob47 14 19 weaknesses weakness NNS cord-339444-f8lfob47 14 20 . . . cord-339444-f8lfob47 15 1 Although although IN cord-339444-f8lfob47 15 2 age age NN cord-339444-f8lfob47 15 3 , , , cord-339444-f8lfob47 15 4 some some DT cord-339444-f8lfob47 15 5 co co NNS cord-339444-f8lfob47 15 6 - - NNS cord-339444-f8lfob47 15 7 medications medication NNS cord-339444-f8lfob47 15 8 , , , cord-339444-f8lfob47 15 9 viral viral JJ cord-339444-f8lfob47 15 10 load load NN cord-339444-f8lfob47 15 11 at at IN cord-339444-f8lfob47 15 12 inclusion inclusion NN cord-339444-f8lfob47 15 13 , , , cord-339444-f8lfob47 15 14 and and CC cord-339444-f8lfob47 15 15 national national JJ cord-339444-f8lfob47 15 16 early early JJ cord-339444-f8lfob47 15 17 warning warning NN cord-339444-f8lfob47 15 18 score score NN cord-339444-f8lfob47 15 19 for for IN cord-339444-f8lfob47 15 20 clinical clinical JJ cord-339444-f8lfob47 15 21 severity severity NN cord-339444-f8lfob47 15 22 were be VBD cord-339444-f8lfob47 15 23 included include VBN cord-339444-f8lfob47 15 24 in in IN cord-339444-f8lfob47 15 25 the the DT cord-339444-f8lfob47 15 26 multivariable multivariable JJ cord-339444-f8lfob47 15 27 model model NN cord-339444-f8lfob47 15 28 , , , cord-339444-f8lfob47 15 29 it -PRON- PRP cord-339444-f8lfob47 15 30 is be VBZ cord-339444-f8lfob47 15 31 surprising surprising JJ cord-339444-f8lfob47 15 32 that that IN cord-339444-f8lfob47 15 33 important important JJ cord-339444-f8lfob47 15 34 factors factor NNS cord-339444-f8lfob47 15 35 such such JJ cord-339444-f8lfob47 15 36 as as IN cord-339444-f8lfob47 15 37 sex sex NN cord-339444-f8lfob47 15 38 and and CC cord-339444-f8lfob47 15 39 chronic chronic JJ cord-339444-f8lfob47 15 40 conditions condition NNS cord-339444-f8lfob47 15 41 were be VBD cord-339444-f8lfob47 15 42 omitted omit VBN cord-339444-f8lfob47 15 43 . . . cord-339444-f8lfob47 16 1 There there EX cord-339444-f8lfob47 16 2 is be VBZ cord-339444-f8lfob47 16 3 evidence evidence NN cord-339444-f8lfob47 16 4 supporting support VBG cord-339444-f8lfob47 16 5 the the DT cord-339444-f8lfob47 16 6 association association NNP cord-339444-f8lfob47 16 7 of of IN cord-339444-f8lfob47 16 8 male male NNP cord-339444-f8lfob47 16 9 sex sex NN cord-339444-f8lfob47 16 10 and and CC cord-339444-f8lfob47 16 11 several several JJ cord-339444-f8lfob47 16 12 chronic chronic JJ cord-339444-f8lfob47 16 13 conditions condition NNS cord-339444-f8lfob47 16 14 , , , cord-339444-f8lfob47 16 15 including include VBG cord-339444-f8lfob47 16 16 those those DT cord-339444-f8lfob47 16 17 reported report VBN cord-339444-f8lfob47 16 18 in in IN cord-339444-f8lfob47 16 19 this this DT cord-339444-f8lfob47 16 20 study study NN cord-339444-f8lfob47 16 21 , , , cord-339444-f8lfob47 16 22 with with IN cord-339444-f8lfob47 16 23 poor poor JJ cord-339444-f8lfob47 16 24 clinical clinical JJ cord-339444-f8lfob47 16 25 outcomes outcome NNS cord-339444-f8lfob47 16 26 [ [ -LRB- cord-339444-f8lfob47 16 27 3 3 CD cord-339444-f8lfob47 16 28 ] ] -RRB- cord-339444-f8lfob47 16 29 . . . cord-339444-f8lfob47 17 1 This this DT cord-339444-f8lfob47 17 2 is be VBZ cord-339444-f8lfob47 17 3 more more RBR cord-339444-f8lfob47 17 4 concerning concern VBG cord-339444-f8lfob47 17 5 in in IN cord-339444-f8lfob47 17 6 view view NN cord-339444-f8lfob47 17 7 of of IN cord-339444-f8lfob47 17 8 the the DT cord-339444-f8lfob47 17 9 significantly significantly RB cord-339444-f8lfob47 17 10 higher high JJR cord-339444-f8lfob47 17 11 prevalence prevalence NN cord-339444-f8lfob47 17 12 of of IN cord-339444-f8lfob47 17 13 chronic chronic JJ cord-339444-f8lfob47 17 14 conditions condition NNS cord-339444-f8lfob47 17 15 in in IN cord-339444-f8lfob47 17 16 patients patient NNS cord-339444-f8lfob47 17 17 with with IN cord-339444-f8lfob47 17 18 poor poor JJ cord-339444-f8lfob47 17 19 clinical clinical JJ cord-339444-f8lfob47 17 20 outcome outcome NN cord-339444-f8lfob47 17 21 in in IN cord-339444-f8lfob47 17 22 this this DT cord-339444-f8lfob47 17 23 study study NN cord-339444-f8lfob47 17 24 . . . cord-339444-f8lfob47 18 1 A a DT cord-339444-f8lfob47 18 2 more more RBR cord-339444-f8lfob47 18 3 effective effective JJ cord-339444-f8lfob47 18 4 handling handling NN cord-339444-f8lfob47 18 5 of of IN cord-339444-f8lfob47 18 6 potential potential JJ cord-339444-f8lfob47 18 7 confounders confounder NNS cord-339444-f8lfob47 18 8 could could MD cord-339444-f8lfob47 18 9 have have VB cord-339444-f8lfob47 18 10 been be VBN cord-339444-f8lfob47 18 11 achieved achieve VBN cord-339444-f8lfob47 18 12 through through IN cord-339444-f8lfob47 18 13 a a DT cord-339444-f8lfob47 18 14 multivariable multivariable JJ cord-339444-f8lfob47 18 15 model model NN cord-339444-f8lfob47 18 16 including include VBG cord-339444-f8lfob47 18 17 all all DT cord-339444-f8lfob47 18 18 known know VBN cord-339444-f8lfob47 18 19 clinically clinically RB cord-339444-f8lfob47 18 20 relevant relevant JJ cord-339444-f8lfob47 18 21 prognostic prognostic JJ cord-339444-f8lfob47 18 22 factors factor NNS cord-339444-f8lfob47 18 23 or or CC cord-339444-f8lfob47 18 24 the the DT cord-339444-f8lfob47 18 25 use use NN cord-339444-f8lfob47 18 26 of of IN cord-339444-f8lfob47 18 27 propensity propensity NN cord-339444-f8lfob47 18 28 score score NN cord-339444-f8lfob47 18 29 matching matching NN cord-339444-f8lfob47 18 30 . . . cord-339444-f8lfob47 19 1 Finally finally RB cord-339444-f8lfob47 19 2 , , , cord-339444-f8lfob47 19 3 due due IN cord-339444-f8lfob47 19 4 to to IN cord-339444-f8lfob47 19 5 the the DT cord-339444-f8lfob47 19 6 retrospective retrospective JJ cord-339444-f8lfob47 19 7 nature nature NN cord-339444-f8lfob47 19 8 of of IN cord-339444-f8lfob47 19 9 the the DT cord-339444-f8lfob47 19 10 study study NN cord-339444-f8lfob47 19 11 , , , cord-339444-f8lfob47 19 12 it -PRON- PRP cord-339444-f8lfob47 19 13 was be VBD cord-339444-f8lfob47 19 14 not not RB cord-339444-f8lfob47 19 15 possible possible JJ cord-339444-f8lfob47 19 16 to to TO cord-339444-f8lfob47 19 17 consider consider VB cord-339444-f8lfob47 19 18 blinding blind VBG cord-339444-f8lfob47 19 19 for for IN cord-339444-f8lfob47 19 20 outcome outcome NN cord-339444-f8lfob47 19 21 assessment assessment NN cord-339444-f8lfob47 19 22 . . . cord-339444-f8lfob47 20 1 Except except IN cord-339444-f8lfob47 20 2 for for IN cord-339444-f8lfob47 20 3 death death NN cord-339444-f8lfob47 20 4 , , , cord-339444-f8lfob47 20 5 clinical clinical JJ cord-339444-f8lfob47 20 6 outcomes outcome NNS cord-339444-f8lfob47 20 7 such such JJ cord-339444-f8lfob47 20 8 as as IN cord-339444-f8lfob47 20 9 transfer transfer NN cord-339444-f8lfob47 20 10 to to IN cord-339444-f8lfob47 20 11 intensive intensive JJ cord-339444-f8lfob47 20 12 care care NN cord-339444-f8lfob47 20 13 unit unit NN cord-339444-f8lfob47 20 14 ( ( -LRB- cord-339444-f8lfob47 20 15 ICU ICU NNP cord-339444-f8lfob47 20 16 ) ) -RRB- cord-339444-f8lfob47 20 17 or or CC cord-339444-f8lfob47 20 18 hospitalization hospitalization NN cord-339444-f8lfob47 20 19 for for IN cord-339444-f8lfob47 20 20 ten ten CD cord-339444-f8lfob47 20 21 days day NNS cord-339444-f8lfob47 20 22 may may MD cord-339444-f8lfob47 20 23 vary vary VB cord-339444-f8lfob47 20 24 across across IN cord-339444-f8lfob47 20 25 physicians physician NNS cord-339444-f8lfob47 20 26 . . . cord-339444-f8lfob47 21 1 For for IN cord-339444-f8lfob47 21 2 example example NN cord-339444-f8lfob47 21 3 , , , cord-339444-f8lfob47 21 4 J J NNP cord-339444-f8lfob47 21 5 o o NN cord-339444-f8lfob47 21 6 u u NN cord-339444-f8lfob47 21 7 r r NN cord-339444-f8lfob47 21 8 n n NN cord-339444-f8lfob47 21 9 a a DT cord-339444-f8lfob47 21 10 l l NN cord-339444-f8lfob47 21 11 P p NN cord-339444-f8lfob47 21 12 r r NN cord-339444-f8lfob47 21 13 e e NN cord-339444-f8lfob47 21 14 -p -p NN cord-339444-f8lfob47 21 15 r r NN cord-339444-f8lfob47 22 1 o o UH cord-339444-f8lfob47 22 2 o o NN cord-339444-f8lfob47 22 3 f f NN cord-339444-f8lfob47 22 4 physicians physician NNS cord-339444-f8lfob47 22 5 may may MD cord-339444-f8lfob47 22 6 have have VB cord-339444-f8lfob47 22 7 a a DT cord-339444-f8lfob47 22 8 higher high JJR cord-339444-f8lfob47 22 9 tendency tendency NN cord-339444-f8lfob47 22 10 to to TO cord-339444-f8lfob47 22 11 keep keep VB cord-339444-f8lfob47 22 12 patients patient NNS cord-339444-f8lfob47 22 13 with with IN cord-339444-f8lfob47 22 14 chronic chronic JJ cord-339444-f8lfob47 22 15 co co NNS cord-339444-f8lfob47 22 16 - - NNS cord-339444-f8lfob47 22 17 morbidities morbidity NNS cord-339444-f8lfob47 22 18 longer longer RB cord-339444-f8lfob47 22 19 in in IN cord-339444-f8lfob47 22 20 hospital hospital NN cord-339444-f8lfob47 22 21 or or CC cord-339444-f8lfob47 22 22 to to TO cord-339444-f8lfob47 22 23 transfer transfer VB cord-339444-f8lfob47 22 24 them -PRON- PRP cord-339444-f8lfob47 22 25 to to IN cord-339444-f8lfob47 22 26 ICU ICU NNP cord-339444-f8lfob47 22 27 . . . cord-339444-f8lfob47 23 1 It -PRON- PRP cord-339444-f8lfob47 23 2 is be VBZ cord-339444-f8lfob47 23 3 worth worth JJ cord-339444-f8lfob47 23 4 noting note VBG cord-339444-f8lfob47 23 5 that that IN cord-339444-f8lfob47 23 6 the the DT cord-339444-f8lfob47 23 7 discussion discussion NN cord-339444-f8lfob47 23 8 of of IN cord-339444-f8lfob47 23 9 the the DT cord-339444-f8lfob47 23 10 study study NN cord-339444-f8lfob47 23 11 limitations limitation NNS cord-339444-f8lfob47 23 12 is be VBZ cord-339444-f8lfob47 23 13 focused focus VBN cord-339444-f8lfob47 23 14 on on IN cord-339444-f8lfob47 23 15 the the DT cord-339444-f8lfob47 23 16 explanation explanation NN cord-339444-f8lfob47 23 17 of of IN cord-339444-f8lfob47 23 18 missing miss VBG cord-339444-f8lfob47 23 19 data datum NNS cord-339444-f8lfob47 23 20 without without IN cord-339444-f8lfob47 23 21 highlighting highlight VBG cord-339444-f8lfob47 23 22 the the DT cord-339444-f8lfob47 23 23 methodological methodological JJ cord-339444-f8lfob47 23 24 concerns concern NNS cord-339444-f8lfob47 23 25 . . . cord-339444-f8lfob47 24 1 In in IN cord-339444-f8lfob47 24 2 conclusion conclusion NN cord-339444-f8lfob47 24 3 , , , cord-339444-f8lfob47 24 4 given give VBN cord-339444-f8lfob47 24 5 the the DT cord-339444-f8lfob47 24 6 many many JJ cord-339444-f8lfob47 24 7 limitations limitation NNS cord-339444-f8lfob47 24 8 raised raise VBN cord-339444-f8lfob47 24 9 above above RB cord-339444-f8lfob47 24 10 , , , cord-339444-f8lfob47 24 11 it -PRON- PRP cord-339444-f8lfob47 24 12 is be VBZ cord-339444-f8lfob47 24 13 advisable advisable JJ cord-339444-f8lfob47 24 14 to to TO cord-339444-f8lfob47 24 15 be be VB cord-339444-f8lfob47 24 16 more more RBR cord-339444-f8lfob47 24 17 careful careful JJ cord-339444-f8lfob47 24 18 about about IN cord-339444-f8lfob47 24 19 claims claim NNS cord-339444-f8lfob47 24 20 of of IN cord-339444-f8lfob47 24 21 association association NN cord-339444-f8lfob47 24 22 between between IN cord-339444-f8lfob47 24 23 HCQ+AZ HCQ+AZ NNP cord-339444-f8lfob47 24 24 and and CC cord-339444-f8lfob47 24 25 low low JJ cord-339444-f8lfob47 24 26 fatality fatality NN cord-339444-f8lfob47 24 27 rates rate NNS cord-339444-f8lfob47 24 28 , , , cord-339444-f8lfob47 24 29 especially especially RB cord-339444-f8lfob47 24 30 when when WRB cord-339444-f8lfob47 24 31 considering consider VBG cord-339444-f8lfob47 24 32 the the DT cord-339444-f8lfob47 24 33 latest late JJS cord-339444-f8lfob47 24 34 evidence evidence NN cord-339444-f8lfob47 24 35 from from IN cord-339444-f8lfob47 24 36 a a DT cord-339444-f8lfob47 24 37 randomized randomized JJ cord-339444-f8lfob47 24 38 controlled control VBN cord-339444-f8lfob47 24 39 trial trial NN cord-339444-f8lfob47 24 40 of of IN cord-339444-f8lfob47 24 41 HCQ HCQ NNP cord-339444-f8lfob47 24 42 as as IN cord-339444-f8lfob47 24 43 postexposure postexposure NN cord-339444-f8lfob47 24 44 prophylaxis prophylaxis NN cord-339444-f8lfob47 24 45 where where WRB cord-339444-f8lfob47 24 46 HCQ HCQ NNP cord-339444-f8lfob47 24 47 did do VBD cord-339444-f8lfob47 24 48 not not RB cord-339444-f8lfob47 24 49 prevent prevent VB cord-339444-f8lfob47 24 50 illness illness NN cord-339444-f8lfob47 24 51 compatible compatible JJ cord-339444-f8lfob47 24 52 with with IN cord-339444-f8lfob47 24 53 COVID-19 COVID-19 NNP cord-339444-f8lfob47 24 54 or or CC cord-339444-f8lfob47 24 55 confirmed confirm VBN cord-339444-f8lfob47 24 56 infection infection NN cord-339444-f8lfob47 24 57 [ [ -LRB- cord-339444-f8lfob47 24 58 4 4 CD cord-339444-f8lfob47 24 59 ] ] -RRB- cord-339444-f8lfob47 24 60 . . . cord-339444-f8lfob47 25 1 In in IN cord-339444-f8lfob47 25 2 addition addition NN cord-339444-f8lfob47 25 3 , , , cord-339444-f8lfob47 25 4 recommendations recommendation NNS cord-339444-f8lfob47 25 5 for for IN cord-339444-f8lfob47 25 6 a a DT cord-339444-f8lfob47 25 7 universal universal JJ cord-339444-f8lfob47 25 8 test test NN cord-339444-f8lfob47 25 9 - - HYPH cord-339444-f8lfob47 25 10 and and CC cord-339444-f8lfob47 25 11 - - HYPH cord-339444-f8lfob47 25 12 treat treat VB cord-339444-f8lfob47 25 13 strategy strategy NN cord-339444-f8lfob47 25 14 made make VBN cord-339444-f8lfob47 25 15 by by IN cord-339444-f8lfob47 25 16 the the DT cord-339444-f8lfob47 25 17 authors author NNS cord-339444-f8lfob47 25 18 should should MD cord-339444-f8lfob47 25 19 be be VB cord-339444-f8lfob47 25 20 tempered temper VBN cord-339444-f8lfob47 25 21 since since IN cord-339444-f8lfob47 25 22 this this DT cord-339444-f8lfob47 25 23 was be VBD cord-339444-f8lfob47 25 24 not not RB cord-339444-f8lfob47 25 25 studied study VBN cord-339444-f8lfob47 25 26 . . . cord-339444-f8lfob47 26 1 Early early JJ cord-339444-f8lfob47 26 2 treatment treatment NN cord-339444-f8lfob47 26 3 of of IN cord-339444-f8lfob47 26 4 COVID-19 covid-19 JJ cord-339444-f8lfob47 26 5 patients patient NNS cord-339444-f8lfob47 26 6 with with IN cord-339444-f8lfob47 26 7 hydroxychloroquine hydroxychloroquine NN cord-339444-f8lfob47 26 8 and and CC cord-339444-f8lfob47 26 9 azithromycin azithromycin NNP cord-339444-f8lfob47 26 10 : : : cord-339444-f8lfob47 26 11 A a DT cord-339444-f8lfob47 26 12 retrospective retrospective JJ cord-339444-f8lfob47 26 13 analysis analysis NN cord-339444-f8lfob47 26 14 of of IN cord-339444-f8lfob47 26 15 1061 1061 CD cord-339444-f8lfob47 26 16 cases case NNS cord-339444-f8lfob47 26 17 in in IN cord-339444-f8lfob47 26 18 Marseille Marseille NNP cord-339444-f8lfob47 26 19 , , , cord-339444-f8lfob47 26 20 France France NNP cord-339444-f8lfob47 26 21 . . . cord-339444-f8lfob47 27 1 Travel travel NN cord-339444-f8lfob47 27 2 medicine medicine NN cord-339444-f8lfob47 27 3 and and CC cord-339444-f8lfob47 27 4 infectious infectious JJ cord-339444-f8lfob47 27 5 disease disease NN cord-339444-f8lfob47 27 6 Factors factor NNS cord-339444-f8lfob47 27 7 associated associate VBN cord-339444-f8lfob47 27 8 with with IN cord-339444-f8lfob47 27 9 hospital hospital NN cord-339444-f8lfob47 27 10 admission admission NN cord-339444-f8lfob47 27 11 and and CC cord-339444-f8lfob47 27 12 critical critical JJ cord-339444-f8lfob47 27 13 illness illness NN cord-339444-f8lfob47 27 14 among among IN cord-339444-f8lfob47 27 15 5279 5279 CD cord-339444-f8lfob47 27 16 people people NNS cord-339444-f8lfob47 27 17 with with IN cord-339444-f8lfob47 27 18 coronavirus coronavirus NN cord-339444-f8lfob47 27 19 disease disease NN cord-339444-f8lfob47 27 20 Risk risk NN cord-339444-f8lfob47 27 21 factors factor NNS cord-339444-f8lfob47 27 22 of of IN cord-339444-f8lfob47 27 23 critical critical JJ cord-339444-f8lfob47 27 24 & & CC cord-339444-f8lfob47 27 25 mortal mortal JJ cord-339444-f8lfob47 27 26 COVID-19 COVID-19 NNP cord-339444-f8lfob47 27 27 cases case NNS cord-339444-f8lfob47 27 28 : : : cord-339444-f8lfob47 27 29 A a DT cord-339444-f8lfob47 27 30 systematic systematic JJ cord-339444-f8lfob47 27 31 literature literature NN cord-339444-f8lfob47 27 32 review review NN cord-339444-f8lfob47 27 33 and and CC cord-339444-f8lfob47 27 34 meta meta NNP cord-339444-f8lfob47 27 35 - - HYPH cord-339444-f8lfob47 27 36 analysis analysis NN cord-339444-f8lfob47 27 37 A A NNP cord-339444-f8lfob47 27 38 Randomized Randomized NNP cord-339444-f8lfob47 27 39 Trial Trial NNP cord-339444-f8lfob47 27 40 of of IN cord-339444-f8lfob47 27 41 Hydroxychloroquine Hydroxychloroquine NNP cord-339444-f8lfob47 27 42 as as IN cord-339444-f8lfob47 27 43 Postexposure Postexposure NNP cord-339444-f8lfob47 27 44 Prophylaxis Prophylaxis NNP cord-339444-f8lfob47 27 45 for for IN cord-339444-f8lfob47 27 46 Covid-19 covid-19 NN cord-339444-f8lfob47 27 47 . . . cord-339444-f8lfob47 28 1 The the DT cord-339444-f8lfob47 28 2 New New NNP cord-339444-f8lfob47 28 3 England England NNP cord-339444-f8lfob47 28 4 journal journal NN cord-339444-f8lfob47 28 5 of of IN cord-339444-f8lfob47 28 6 medicine medicine NNP cord-339444-f8lfob47 29 1 All all DT cord-339444-f8lfob47 29 2 authors author NNS cord-339444-f8lfob47 29 3 contributed contribute VBD cord-339444-f8lfob47 29 4 to to IN cord-339444-f8lfob47 29 5 writing write VBG cord-339444-f8lfob47 29 6 this this DT cord-339444-f8lfob47 29 7 article article NN cord-339444-f8lfob47 29 8 and and CC cord-339444-f8lfob47 29 9 approved approve VBD cord-339444-f8lfob47 29 10 its -PRON- PRP$ cord-339444-f8lfob47 29 11 final final JJ cord-339444-f8lfob47 29 12 version version NN cord-339444-f8lfob47 29 13 . . . cord-339444-f8lfob47 30 1 There there EX cord-339444-f8lfob47 30 2 is be VBZ cord-339444-f8lfob47 30 3 no no DT cord-339444-f8lfob47 30 4 funding funding NN cord-339444-f8lfob47 30 5 source source NN cord-339444-f8lfob47 30 6 used use VBN cord-339444-f8lfob47 30 7 for for IN cord-339444-f8lfob47 30 8 this this DT cord-339444-f8lfob47 30 9 paper paper NN cord-339444-f8lfob47 30 10 . . . cord-339444-f8lfob47 31 1 There there EX cord-339444-f8lfob47 31 2 is be VBZ cord-339444-f8lfob47 31 3 no no DT cord-339444-f8lfob47 31 4 competing compete VBG cord-339444-f8lfob47 31 5 interest interest NN cord-339444-f8lfob47 31 6 . . .