id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344953-gtg12hiu	Prather, Randall S.	Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)	2017-10-17		.txt	text/plain	2628	158	55	title: Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection, were completely protected from PRRSV in dams possessing a complete knockout of the CD163 receptor. The hypothesis to be tested was that the presence of the CD163 KO genotype of the dam would be sufficient to protect fetuses following maternal infection with PRRSV. PRRSV nucleic acid, measured at 7 dpi, showed a viremia level for Dam No. 139 of 5.5 log 10 templates per reaction, demonstrating the presence of a productive PRRSV infection. Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus	./cache/cord-344953-gtg12hiu.txt	./txt/cord-344953-gtg12hiu.txt