id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342122-certy2v8	Ruscitti, Piero	Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations	2020-07-22		.txt	text/plain	4624	236	44	In this work, we tested (1) FeH and FeL in bone marrow (BM) and sera in patients with macrophage activation syndrome (MAS); (2) pro-inflammatory effects of ferritin, FeL, and FeH on macrophages; (3) ability of FeH-stimulated macrophages to stimulate the proliferation of peripheral blood mononuclear cells (PBMCs); (4) production of mature IL-1β and IL-12p70 in extracellular compartments of FeH-stimulated macrophages. Finally, www.nature.com/scientificreports/ FeH-treated macrophages enhanced the proliferation of co-cultured PBMCs. Taking together all these results and considering that AOSD and MAS could be included in the so-called "hyperferritinaemic syndrome" 14 , our data could reinforce the hypothesis that higher levels of ferritin may not only be considered a consequence or an epiphenomenon of the inflammation, but it may actively play a role in pathogenic mechanisms of those diseases, thus enhancing the inflammatory burden.	./cache/cord-342122-certy2v8.txt	./txt/cord-342122-certy2v8.txt