id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329424-hmsidrc7	Grunwell, Jocelyn R.	Differential type I interferon response and primary airway neutrophil extracellular trap release in children with acute respiratory distress syndrome	2020-11-04		.txt	text/plain	4860	274	38	title: Differential type I interferon response and primary airway neutrophil extracellular trap release in children with acute respiratory distress syndrome Since viral lower respiratory tract infections are a primary trigger for PARDS, we questioned whether differential ISG expression was associated with neutrophil responses in intubated children at risk or with PARDS. We hypothesized that children with PARDS would have a greater type I IFN response resulting in more neutrophil extracellular trap (NET) release. Our study assessed neutrophil activation, the differential expression of ISGs and activation of the STAT1 signaling pathway, and NETosis in the airways of intubated children with acute respiratory failure due to lower respiratory tract infections. While we detected higher type I IFN signaling and NET production in the airways of children with versus without PARDS, due to the clinical nature of our study, we are not able to attribute causation of neutrophil dysfunction to high ISG expression in study participants.	./cache/cord-329424-hmsidrc7.txt	./txt/cord-329424-hmsidrc7.txt