id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318187-c59c9vi3	Basu, Saikat	Numerical evaluation of spray position for improved nasal drug delivery	2020-06-29		.txt	text/plain	7843	375	44	The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Of interest are nasal spray simulation studies on in silico models, re-constructed from medical imaging, to measure drug delivery along the nasal passages 9 , in the sinuses 10, 11 , and on the effects of surgical alterations of the anatomy on nasal airflow [12] [13] [14] [15] as well as on topical transport of drugs [16] [17] [18] [19] . The computational fluid dynamics (CFD) models of droplet transport and the in silico prediction of their deposition sites along the nasal airway walls have been compared with in vitro spray experiments in 3D-printed solid replicas of the same anatomic reconstructions.	./cache/cord-318187-c59c9vi3.txt	./txt/cord-318187-c59c9vi3.txt