id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293372-saqoft9p	Heffner, Kelley	Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities	2020-09-28		.txt	text/plain	4862	274	45	Quantitative proteomics data were obtained from two CHO cell lines (CHO-S and CHO DG44) and compared with seven Chinese hamster (Cricetulus griseus) tissues (brain, heart, kidney, liver, lung, ovary and spleen) by tandem mass tag (TMT) labeling followed by mass spectrometry, providing a comprehensive hamster tissue and cell line proteomics atlas. This study was undertaken to compare protein expression of various CHO cell lines and hamster tissues, resulting in the most comprehensive multi-tissue analysis of the Cricetulus griseus proteome (Fig. 1A) . Similar to the ovary and lung comparison, there are a greater number of proteins with higher expression in the heart tissue when compared to cell lines. These differences highlight the role of tissues in executing key organ functions which require a specific metabolic processes, such as transport and communication, in comparison to CHO cells, which are focused on replication and gene expression, characteristics useful for rapid growth and the production of biologics.	./cache/cord-293372-saqoft9p.txt	./txt/cord-293372-saqoft9p.txt