id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286413-a7wue2e3	Cohen, Isaac V.	Cardiac adverse events associated with chloroquine and hydroxychloroquine exposure in 20 years of drug safety surveillance reports	2020-11-05		.txt	text/plain	3609	205	48	title: Cardiac adverse events associated with chloroquine and hydroxychloroquine exposure in 20 years of drug safety surveillance reports The cardiac AEs of these therapeutics are of increased concern since a subset of patients infected with COVID-19 present with cardiac injury, suggesting a relevant cardiovascular involvement in the pathophysiology of the disease 22 . The goal of this study is to reanalyze the extensive clinical data of CQ and HCQ cardiac AEs collected during the last 20 years to derive the strength of the associations and, more importantly, contributing risk factors. In our study we analyzed 702,274 FDA adverse event reports divided into CQ, HCQ and control cohorts to determine their association with cardiac AEs when taking into account other factors. The regression model was instrumental to exclude this aspirin association from the quantification of the direct cardiac side effects of CQ and HCQ, which remained significant after adjustment ( Generalizability of results to COVID-19 treatment with CQ and HCQ.	./cache/cord-286413-a7wue2e3.txt	./txt/cord-286413-a7wue2e3.txt