id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284582-xwedgllw	Korabecna, M.	Cell-free DNA in plasma as an essential immune system regulator	2020-10-15		.txt	text/plain	5714	306	46	These expression profiles provide evidence that the presence of cfDNA and its clearance in plasma of healthy individuals regulate fundamental mechanisms of the inflammation process and tissue homeostasis. We used native human plasma samples obtained from healthy volunteers with no animal serum addition to the cultivation medium in order to avoid the presence of uncharacterized animal cfDNA and DNases in the experiments. We used the validation phase results to perform a direct comparison of signaling pathways activated in cells as a consequence of their treatment with NP or TP samples (Table 1a , b) using the database Reactome. The changes in expression profiles of selected validated genes were detectable after the decrease of cfDNA levels to 69.10% of its original native concentration as the result of endogenous DNAse I activity ( Supplementary Fig. 1 ). However, the cells treated with identical plasma samples with degraded cfDNA directly activate IIR with elevated production of mRNA for interleukin 8 at the transcriptomic level.	./cache/cord-284582-xwedgllw.txt	./txt/cord-284582-xwedgllw.txt