id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271328-zdf5ji4k	Gu, Hongjing	Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus	2016-01-27		.txt	text/plain	3910	196	52	In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. To determine the role of ACE2 in RSV-induced lung injury, we first measured the levels of Ang II in the plasma of RSV-infected patients. Importantly, ACE2 protein levels were dramatically decreased in lung homogenates from mice infected with RSV BJ016 virus at 3 days post-infection (p < 0.01; Fig. 1d ). Our data suggest that RSV infection causes severe lung injury in an experimental mouse model and in patients, at least in part by modulating the RAS system via down-regulation of the ACE2-AT1R axis. Importantly, the levels of Ang II were elevated following down-regulation of ACE2, causing severe lung injury via AT1R during the process of RSV infection (Fig. 5d) .	./cache/cord-271328-zdf5ji4k.txt	./txt/cord-271328-zdf5ji4k.txt