id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004170-ri5qsarz	Yashima, Nozomi	Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit	2020-01-16		.txt	text/plain	3584	234	44	title: Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit Abnormal in-circuit elevation in pressure was associated with deposition of extracellular DNA on the outlet surface of the filter. In-circuit pressure was elevated at the oxygenator if heparin was administered in whole blood that was stored for 7 days (Fig. S1B) . Then, we examined whether leukocyte stimulation results in elevation of in-circuit pressure since previous studies have suggested that stimulated leukocytes are prone to releasing DNA into the extracellular space 13 . Our study showed that leukocyte-derived extracellular DNA induced an elevation of in-circuit pressure. Our study suggested that extracellular DNA from disrupted leukocytes contributed to elevation of in-circuit pressure. In conclusion, our study shows that leukocyte-derived extracellular DNA contributes to abnormal in-circuit elevation of pressure in an ex vivo circuit.	./cache/cord-004170-ri5qsarz.txt	./txt/cord-004170-ri5qsarz.txt