id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004150-ybikajhh	Nyarko, Prince B.	Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch at the whole transcriptome level	2020-01-14		.txt	text/plain	6221	323	39	The genes with most markedly increased expression included members of the erythrocyte binding antigens (EBA), reticulocyte binding homologues (RH), surface associated interspersed proteins (SURFIN), exported protein family 1 (EPF1) and Plasmodium Helical Interspersed Sub-Telomeric (PHIST) gene families. The data indicate changes in expression of a repertoire of genes not previously associated with erythrocyte invasion phenotypes, suggesting the possibility that moving suspension culture may also select for other traits. Additionally, a large number of virulence associated genes, including members of the surface-associated interspersed protein (SURFIN) family, exported protein family 1 (EPF1), ring exported protein 1 (REX1) and interspersed repeat antigen (FIRA); all of which are exported into host erythrocytes, were significantly expressed at higher levels in SP parasites relative to BL (Fig. 2) . A comparison of the levels of differential expression of the eba and rh gene between ST and SP parasites in the current RNA sequencing study and our previous RT-qPCR analysis shows a strong positive correlation of results from the two studies ( Supplementary Fig. 12 ).	./cache/cord-004150-ybikajhh.txt	./txt/cord-004150-ybikajhh.txt