id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004062-yxx3xxio	Lee, Ing-Kit	Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease	2019-12-24		.txt	text/plain	3744	191	47	We performed an in vitro study to evaluate the sequential immunological reactions and viral load in dengue virus type 2-infected mononuclear cells of patients with ESRD (n = 34) and in healthy controls (n = 30). The concentrations of interleukins (IL)-1 receptor antagonist (Ra), IL-2, IL-6, IL-8, IL-10, IL-12p40, granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1b (MIP-1b), vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α and viral load cycle threshold (Ct) were measured in the dengue virus type 2-infected mononuclear cells at 6 h, 24 h, 48 h, and 72 h post-infection. In the present study, eleven immune mediators and viral load Ct values were measured in DENV2-infected mononuclear cells of adults with ESRD, and in healthy participants. Our results have been somewhat inconsistent with the reported overwhelming immune activation that is associated with dengue disease severity 5, 7 ; however, our findings clearly reflect the impairment of immune responses in vitro study of DENV2-infected mononuclear cells in ESRD patients.	./cache/cord-004062-yxx3xxio.txt	./txt/cord-004062-yxx3xxio.txt