id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003055-88q36g00	Imai, Kenji	Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model	2018-06-15		.txt	text/plain	6212	313	41	The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H(2)) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H(2) attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Since MIA has been considered to be a cause of behavioral abnormalities in offspring, including ASD/ Schizophrenia-like behavior, we subsequently evaluated the effect of LPS and maternal administration of HW on short-term memory, sociability, social novelty, and sensorimotor gating. Based on those findings, we subsequently performed Nissl staining and evaluated the number of neurons in the amygdala, cerebral cortex, and hippocampus to investigate the brain regions related to the results of the behavioral deficits induced by LPS exposure.	./cache/cord-003055-88q36g00.txt	./txt/cord-003055-88q36g00.txt