id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002389-k86hzbbx	Fan, Hanlu	Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium	2017-01-24		.txt	text/plain	5147	274	49	As all stages of Ebola entry (binding to and internalization from the cell surface, as well as trafficking to and fusion with the limiting membrane of endolysosome) are mediated by trimeric GP spikes arrayed around the Ebola particles 29, 30 , so the pseudovirion model with Ebola GP can simulate the stages of wild-type Ebola entry, and several groups have studied the Ebola entry mechanism and screened the anti-Ebola entry drugs with Ebola pseudovirion model 3, 6, 31, 32 . To determine whether endolysosomal calcium is involved in the mechanism of Ebola entry inhibition, we treated HepG2 cell line with a high-affinity Rhod-dextran to chelate intraluminal calcium, and infected the cells with Ebola, WSN, or VSV pseudovirions.	./cache/cord-002389-k86hzbbx.txt	./txt/cord-002389-k86hzbbx.txt