id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002045-m44fic4g	Horie, Masayuki	An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus	2016-05-13		.txt	text/plain	4805	312	59	Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Furthermore, we showed that the EBLLs evolved under purifying selection and still possess functional motifs conserved among the Mononegavirales RdRps. These results strongly suggest that the EBLL elements encode functional proteins that may be RdRps. ORF screening for these elements in several mammalian species and found an EBLL element in the bat species Eptesicus fuscus (designated efEBLL-1; accession number ALEH01013293). Notably, this element (eEBLL-1) contains a 1,718-amino acid ORF that was conserved for more than 11.8 MY and included almost all of the sequence motifs essential for the enzymatic activity of a RNA virus RdRp. To the best of our knowledge, eEBLL-1 is the first example of an RNA virus-derived RdRp encoded by the mammalian genome.	./cache/cord-002045-m44fic4g.txt	./txt/cord-002045-m44fic4g.txt