id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001829-rwnbxmt4	Lu, Yi-Fan	IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance	2015-11-04		.txt	text/plain	7156	384	48	Genome-wide association studies performed on diverse patient populations have identified polymorphisms near the interferon-λ 3 (IFNL3; formerly IL28B) gene that predict the efficacy of interferon-based therapy for chronic infection. The differential effects on mRNA versus protein levels strongly suggest that the IFNL3 3′ UTR regulates gene expression by repressing the efficiency of mRNA translation rather than mRNA abundance in HeLa cells. We used polysome profiling to examine whether the variant IFNL3 reporter mRNAs were differentially associated with translating ribosomes in stable HeLa cell lines. Although rs4803217 is not independently associated with patient phenotypes in the cohort we analyzed, this SNP occurs in the 3′ UTR of IFNL3 and showed clear functional effects on reporter gene expression, suggesting a role for this variant in control of HCV infection.	./cache/cord-001829-rwnbxmt4.txt	./txt/cord-001829-rwnbxmt4.txt