id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001675-9717nzr7	Sugiyama, Michael G.	The Tie2-agonist Vasculotide rescues mice from influenza virus infection	2015-06-05		.txt	text/plain	4824	260	47	Here we demonstrate that the Tie2-agonist tetrameric peptide Vasculotide improves survival in murine models of severe influenza, even if administered as late as 72 hours after infection; the benefit was observed using three strains of the virus and two strains of mice. While the drug had no effect on human lung endothelial proliferation (Supplemental Figure 8) , it significantly attenuated lung endothelial apoptosis in vitro in response to influenza virus, as assessed by cleavage of caspase-3 (Supplemental Figure 7c ); we observed a similar reduction in cleaved caspase-3 in lungs from infected mice who received Vasculotide (Supplemental Figure 7d ). First, these data strongly implicate failure of the lung endothelial barrier as the cause of death in murine models of severe influenza, as Vasculotide conferred a significant survival benefit against multiple strains of the virus in two strains of mice.	./cache/cord-001675-9717nzr7.txt	./txt/cord-001675-9717nzr7.txt