id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001116-2yvyiiuy	Nikas, Jason B.	Inflammation and Immune System Activation in Aging: A Mathematical Approach	2013-11-19		.txt	text/plain	4534	199	49	Since those functions are associated with the hippocampus, I analyzed the global gene expression data from post-mortem hippocampal tissue of 25 old (age ≥ 60 yrs) and 15 young (age ≤ 45 yrs) cognitively intact human subjects. Having employed three different and independent methods of statistical significance, namely, ROC curve analysis, fold change, and P-value, I was able to identify 36 genes that were the most significant in terms of differential expression. The seven genes [C4A (C4B), ADORA3, MS4A7, BCL6, CD44, C3AR1, and HLA-DRB1], which are the constituent input variables of the model (F 1 super variable), and all of which are -in terms of function -inflammation or immune system activation genes (Table 1) , were all found to be over-expressed in the old subjects compared with the young subjects (Table 1) .	./cache/cord-001116-2yvyiiuy.txt	./txt/cord-001116-2yvyiiuy.txt