id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352747-o30wbq6m	Pereira, C. A.	Mouse Hepatitis Virus 3 Binding to Macrophages Correlates with Resistance to Experimental Infection	2008-10-09		.txt	text/plain	2350	106	47	Lucchiari, to his laboratory, and in 1992, we published a paper showing that the pattern of protein synthesized in the liver was profoundly perturbed upon mouse hepatitis viruses (MHV) infection [1] , and that some gene products related to the induction of antiviral state in macrophages resistant and sensitive to interferon-g (IFN-g) could be readily characterized [2] . A few years later, supported by the Swiss National Science Foundation, we have found that IFN-g was capable of inducing a downregulation of the main viral receptor only in macrophages originated from resistant mice, explaining at least in part the cellular and molecular basis of mouse resistance to MHV infection [3, 4] . Our quantitative biology studies [1, 4] showing upregulated and downregulated proteins and genes in resistant and susceptible macrophages opened a great perspective for investigations of the biological role of these cells and have also confirmed the downregulation of an MHV3 receptor gene by IFN-g activation [4] .	./cache/cord-352747-o30wbq6m.txt	./txt/cord-352747-o30wbq6m.txt