id sid tid token lemma pos cord-312743-9e4yufo5 1 1 key key NN cord-312743-9e4yufo5 1 2 : : : cord-312743-9e4yufo5 2 1 cord-312743 cord-312743 NNP cord-312743-9e4yufo5 2 2 - - HYPH cord-312743-9e4yufo5 2 3 9e4yufo5 9e4yufo5 CD cord-312743-9e4yufo5 2 4 authors author NNS cord-312743-9e4yufo5 2 5 : : : cord-312743-9e4yufo5 2 6 Breiman Breiman NNP cord-312743-9e4yufo5 2 7 , , , cord-312743-9e4yufo5 2 8 Adrien Adrien NNP cord-312743-9e4yufo5 2 9 ; ; : cord-312743-9e4yufo5 2 10 Ruvën Ruvën NNP cord-312743-9e4yufo5 2 11 - - HYPH cord-312743-9e4yufo5 2 12 Clouet Clouet NNP cord-312743-9e4yufo5 2 13 , , , cord-312743-9e4yufo5 2 14 Nathalie Nathalie NNP cord-312743-9e4yufo5 2 15 ; ; : cord-312743-9e4yufo5 2 16 Le Le NNP cord-312743-9e4yufo5 2 17 Pendu Pendu NNP cord-312743-9e4yufo5 2 18 , , , cord-312743-9e4yufo5 2 19 Jacques Jacques NNP cord-312743-9e4yufo5 2 20 title title NN cord-312743-9e4yufo5 2 21 : : : cord-312743-9e4yufo5 2 22 Harnessing harness VBG cord-312743-9e4yufo5 2 23 the the DT cord-312743-9e4yufo5 2 24 natural natural JJ cord-312743-9e4yufo5 2 25 anti anti JJ cord-312743-9e4yufo5 2 26 - - JJ cord-312743-9e4yufo5 2 27 glycan glycan JJ cord-312743-9e4yufo5 2 28 immune immune JJ cord-312743-9e4yufo5 2 29 response response NN cord-312743-9e4yufo5 2 30 to to TO cord-312743-9e4yufo5 2 31 limit limit VB cord-312743-9e4yufo5 2 32 the the DT cord-312743-9e4yufo5 2 33 transmission transmission NN cord-312743-9e4yufo5 2 34 of of IN cord-312743-9e4yufo5 2 35 enveloped envelop VBN cord-312743-9e4yufo5 2 36 viruses virus NNS cord-312743-9e4yufo5 2 37 such such JJ cord-312743-9e4yufo5 2 38 as as IN cord-312743-9e4yufo5 2 39 SARS SARS NNP cord-312743-9e4yufo5 2 40 - - HYPH cord-312743-9e4yufo5 2 41 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 2 42 date date NN cord-312743-9e4yufo5 2 43 : : : cord-312743-9e4yufo5 2 44 2020 2020 CD cord-312743-9e4yufo5 2 45 - - HYPH cord-312743-9e4yufo5 2 46 05 05 CD cord-312743-9e4yufo5 2 47 - - SYM cord-312743-9e4yufo5 2 48 21 21 CD cord-312743-9e4yufo5 2 49 journal journal NN cord-312743-9e4yufo5 2 50 : : : cord-312743-9e4yufo5 2 51 PLoS PLoS NNP cord-312743-9e4yufo5 2 52 Pathog Pathog NNP cord-312743-9e4yufo5 2 53 DOI DOI NNP cord-312743-9e4yufo5 2 54 : : : cord-312743-9e4yufo5 2 55 10.1371 10.1371 CD cord-312743-9e4yufo5 2 56 / / SYM cord-312743-9e4yufo5 2 57 journal.ppat.1008556 journal.ppat.1008556 NNP cord-312743-9e4yufo5 2 58 sha sha NNP cord-312743-9e4yufo5 2 59 : : : cord-312743-9e4yufo5 2 60 509bb8e8a2851004f8f7f95a7757b189520123a4 509bb8e8a2851004f8f7f95a7757b189520123a4 CD cord-312743-9e4yufo5 2 61 doc_id doc_id CD cord-312743-9e4yufo5 2 62 : : : cord-312743-9e4yufo5 2 63 312743 312743 CD cord-312743-9e4yufo5 2 64 cord_uid cord_uid NNS cord-312743-9e4yufo5 2 65 : : : cord-312743-9e4yufo5 3 1 9e4yufo5 9e4yufo5 CD cord-312743-9e4yufo5 4 1 nan nan NNP cord-312743-9e4yufo5 4 2 domain domain NN cord-312743-9e4yufo5 4 3 [ [ -LRB- cord-312743-9e4yufo5 4 4 10 10 CD cord-312743-9e4yufo5 4 5 ] ] -RRB- cord-312743-9e4yufo5 4 6 . . . cord-312743-9e4yufo5 5 1 The the DT cord-312743-9e4yufo5 5 2 recently recently RB cord-312743-9e4yufo5 5 3 emerged emerge VBN cord-312743-9e4yufo5 5 4 SARS SARS NNP cord-312743-9e4yufo5 5 5 - - HYPH cord-312743-9e4yufo5 5 6 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 5 7 responsible responsible JJ cord-312743-9e4yufo5 5 8 for for IN cord-312743-9e4yufo5 5 9 COVID-19 covid-19 NN cord-312743-9e4yufo5 5 10 shows show VBZ cord-312743-9e4yufo5 5 11 overall overall JJ cord-312743-9e4yufo5 5 12 conservation conservation NN cord-312743-9e4yufo5 5 13 of of IN cord-312743-9e4yufo5 5 14 the the DT cord-312743-9e4yufo5 5 15 S S NNP cord-312743-9e4yufo5 5 16 protein protein NN cord-312743-9e4yufo5 5 17 glycosylation glycosylation NN cord-312743-9e4yufo5 5 18 sites site NNS cord-312743-9e4yufo5 5 19 . . . cord-312743-9e4yufo5 6 1 The the DT cord-312743-9e4yufo5 6 2 primary primary JJ cord-312743-9e4yufo5 6 3 target target NN cord-312743-9e4yufo5 6 4 organ organ NN cord-312743-9e4yufo5 6 5 of of IN cord-312743-9e4yufo5 6 6 human human JJ cord-312743-9e4yufo5 6 7 coronaviruses coronaviruse NNS cord-312743-9e4yufo5 6 8 , , , cord-312743-9e4yufo5 6 9 including include VBG cord-312743-9e4yufo5 6 10 both both CC cord-312743-9e4yufo5 6 11 SARS SARS NNP cord-312743-9e4yufo5 6 12 and and CC cord-312743-9e4yufo5 6 13 SARS SARS NNP cord-312743-9e4yufo5 6 14 - - HYPH cord-312743-9e4yufo5 6 15 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 6 16 , , , cord-312743-9e4yufo5 6 17 is be VBZ cord-312743-9e4yufo5 6 18 the the DT cord-312743-9e4yufo5 6 19 lung lung NN cord-312743-9e4yufo5 6 20 and and CC cord-312743-9e4yufo5 6 21 both both DT cord-312743-9e4yufo5 6 22 viruses virus NNS cord-312743-9e4yufo5 6 23 use use VBP cord-312743-9e4yufo5 6 24 angiotensin angiotensin NN cord-312743-9e4yufo5 6 25 converting convert VBG cord-312743-9e4yufo5 6 26 enzyme enzyme NN cord-312743-9e4yufo5 6 27 2 2 CD cord-312743-9e4yufo5 6 28 ( ( -LRB- cord-312743-9e4yufo5 6 29 ACE2 ACE2 NNP cord-312743-9e4yufo5 6 30 ) ) -RRB- cord-312743-9e4yufo5 6 31 as as IN cord-312743-9e4yufo5 6 32 receptor receptor NN cord-312743-9e4yufo5 6 33 [ [ -LRB- cord-312743-9e4yufo5 6 34 11 11 CD cord-312743-9e4yufo5 6 35 ] ] -RRB- cord-312743-9e4yufo5 6 36 . . . cord-312743-9e4yufo5 7 1 Being be VBG cord-312743-9e4yufo5 7 2 expressed express VBN cord-312743-9e4yufo5 7 3 on on IN cord-312743-9e4yufo5 7 4 lung lung NN cord-312743-9e4yufo5 7 5 alveolar alveolar NN cord-312743-9e4yufo5 7 6 epithelial epithelial JJ cord-312743-9e4yufo5 7 7 cells cell NNS cord-312743-9e4yufo5 7 8 , , , cord-312743-9e4yufo5 7 9 chiefly chiefly RB cord-312743-9e4yufo5 7 10 type type NN cord-312743-9e4yufo5 7 11 2 2 CD cord-312743-9e4yufo5 7 12 pneumocytes pneumocyte NNS cord-312743-9e4yufo5 7 13 , , , cord-312743-9e4yufo5 7 14 [ [ -LRB- cord-312743-9e4yufo5 7 15 12 12 CD cord-312743-9e4yufo5 7 16 , , , cord-312743-9e4yufo5 7 17 13 13 CD cord-312743-9e4yufo5 7 18 ] ] -RRB- cord-312743-9e4yufo5 7 19 , , , cord-312743-9e4yufo5 7 20 it -PRON- PRP cord-312743-9e4yufo5 7 21 is be VBZ cord-312743-9e4yufo5 7 22 to to TO cord-312743-9e4yufo5 7 23 be be VB cord-312743-9e4yufo5 7 24 expected expect VBN cord-312743-9e4yufo5 7 25 that that IN cord-312743-9e4yufo5 7 26 the the DT cord-312743-9e4yufo5 7 27 glycosylation glycosylation NN cord-312743-9e4yufo5 7 28 of of IN cord-312743-9e4yufo5 7 29 SARS SARS NNP cord-312743-9e4yufo5 7 30 - - HYPH cord-312743-9e4yufo5 7 31 CoV CoV NNP cord-312743-9e4yufo5 7 32 and and CC cord-312743-9e4yufo5 7 33 SARS SARS NNP cord-312743-9e4yufo5 7 34 - - HYPH cord-312743-9e4yufo5 7 35 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 7 36 should should MD cord-312743-9e4yufo5 7 37 be be VB cord-312743-9e4yufo5 7 38 similar similar JJ cord-312743-9e4yufo5 7 39 . . . cord-312743-9e4yufo5 8 1 Using use VBG cord-312743-9e4yufo5 8 2 a a DT cord-312743-9e4yufo5 8 3 cellular cellular JJ cord-312743-9e4yufo5 8 4 experimental experimental JJ cord-312743-9e4yufo5 8 5 model model NN cord-312743-9e4yufo5 8 6 , , , cord-312743-9e4yufo5 8 7 our -PRON- PRP$ cord-312743-9e4yufo5 8 8 group group NN cord-312743-9e4yufo5 8 9 showed show VBD cord-312743-9e4yufo5 8 10 that that IN cord-312743-9e4yufo5 8 11 the the DT cord-312743-9e4yufo5 8 12 interaction interaction NN cord-312743-9e4yufo5 8 13 between between IN cord-312743-9e4yufo5 8 14 SARS SARS NNP cord-312743-9e4yufo5 8 15 - - HYPH cord-312743-9e4yufo5 8 16 CoV CoV NNP cord-312743-9e4yufo5 8 17 S S NNP cord-312743-9e4yufo5 8 18 protein protein NN cord-312743-9e4yufo5 8 19 and and CC cord-312743-9e4yufo5 8 20 ACE2 ACE2 NNP cord-312743-9e4yufo5 8 21 could could MD cord-312743-9e4yufo5 8 22 be be VB cord-312743-9e4yufo5 8 23 specifically specifically RB cord-312743-9e4yufo5 8 24 blocked block VBN cord-312743-9e4yufo5 8 25 in in IN cord-312743-9e4yufo5 8 26 a a DT cord-312743-9e4yufo5 8 27 dose dose NN cord-312743-9e4yufo5 8 28 - - HYPH cord-312743-9e4yufo5 8 29 dependent dependent JJ cord-312743-9e4yufo5 8 30 manner manner NN cord-312743-9e4yufo5 8 31 by by IN cord-312743-9e4yufo5 8 32 anti anti JJ cord-312743-9e4yufo5 8 33 - - JJ cord-312743-9e4yufo5 8 34 A a DT cord-312743-9e4yufo5 8 35 blood blood NN cord-312743-9e4yufo5 8 36 group group NN cord-312743-9e4yufo5 8 37 antibodies antibody NNS cord-312743-9e4yufo5 8 38 when when WRB cord-312743-9e4yufo5 8 39 the the DT cord-312743-9e4yufo5 8 40 S S NNP cord-312743-9e4yufo5 8 41 protein protein NN cord-312743-9e4yufo5 8 42 was be VBD cord-312743-9e4yufo5 8 43 synthesized synthesize VBN cord-312743-9e4yufo5 8 44 by by IN cord-312743-9e4yufo5 8 45 cells cell NNS cord-312743-9e4yufo5 8 46 that that WDT cord-312743-9e4yufo5 8 47 expressed express VBD cord-312743-9e4yufo5 8 48 the the DT cord-312743-9e4yufo5 8 49 A a DT cord-312743-9e4yufo5 8 50 histo histo JJ cord-312743-9e4yufo5 8 51 - - HYPH cord-312743-9e4yufo5 8 52 blood blood NN cord-312743-9e4yufo5 8 53 group group NN cord-312743-9e4yufo5 8 54 antigen antigen NN cord-312743-9e4yufo5 8 55 following follow VBG cord-312743-9e4yufo5 8 56 transfection transfection NN cord-312743-9e4yufo5 8 57 by by IN cord-312743-9e4yufo5 8 58 the the DT cord-312743-9e4yufo5 8 59 appropriate appropriate JJ cord-312743-9e4yufo5 8 60 glycosyltransferases glycosyltransferase NNS cord-312743-9e4yufo5 8 61 cDNA cdna NN cord-312743-9e4yufo5 8 62 [ [ -LRB- cord-312743-9e4yufo5 8 63 14 14 CD cord-312743-9e4yufo5 8 64 ] ] -RRB- cord-312743-9e4yufo5 8 65 . . . cord-312743-9e4yufo5 9 1 These these DT cord-312743-9e4yufo5 9 2 observations observation NNS cord-312743-9e4yufo5 9 3 suggested suggest VBD cord-312743-9e4yufo5 9 4 that that IN cord-312743-9e4yufo5 9 5 , , , cord-312743-9e4yufo5 9 6 when when WRB cord-312743-9e4yufo5 9 7 produced produce VBN cord-312743-9e4yufo5 9 8 in in IN cord-312743-9e4yufo5 9 9 cells cell NNS cord-312743-9e4yufo5 9 10 that that WDT cord-312743-9e4yufo5 9 11 express express VBP cord-312743-9e4yufo5 9 12 the the DT cord-312743-9e4yufo5 9 13 A A NNP cord-312743-9e4yufo5 9 14 or or CC cord-312743-9e4yufo5 9 15 B b NN cord-312743-9e4yufo5 9 16 blood blood NN cord-312743-9e4yufo5 9 17 group group NN cord-312743-9e4yufo5 9 18 enzymes enzyme NNS cord-312743-9e4yufo5 9 19 , , , cord-312743-9e4yufo5 9 20 infectious infectious JJ cord-312743-9e4yufo5 9 21 SARS SARS NNP cord-312743-9e4yufo5 9 22 virions virion NNS cord-312743-9e4yufo5 9 23 are be VBP cord-312743-9e4yufo5 9 24 decorated decorate VBN cord-312743-9e4yufo5 9 25 by by IN cord-312743-9e4yufo5 9 26 the the DT cord-312743-9e4yufo5 9 27 corresponding corresponding JJ cord-312743-9e4yufo5 9 28 glycan glycan NN cord-312743-9e4yufo5 9 29 antigens antigen NNS cord-312743-9e4yufo5 9 30 and and CC cord-312743-9e4yufo5 9 31 that that IN cord-312743-9e4yufo5 9 32 the the DT cord-312743-9e4yufo5 9 33 presence presence NN cord-312743-9e4yufo5 9 34 of of IN cord-312743-9e4yufo5 9 35 anti anti JJ cord-312743-9e4yufo5 9 36 - - JJ cord-312743-9e4yufo5 9 37 A a JJ cord-312743-9e4yufo5 9 38 and and CC cord-312743-9e4yufo5 9 39 anti anti JJ cord-312743-9e4yufo5 9 40 - - JJ cord-312743-9e4yufo5 9 41 B b JJ cord-312743-9e4yufo5 9 42 antibodies antibody NNS cord-312743-9e4yufo5 9 43 in in IN cord-312743-9e4yufo5 9 44 blood blood NN cord-312743-9e4yufo5 9 45 group group NN cord-312743-9e4yufo5 9 46 O o NN cord-312743-9e4yufo5 9 47 individuals individual NNS cord-312743-9e4yufo5 9 48 could could MD cord-312743-9e4yufo5 9 49 prevent prevent VB cord-312743-9e4yufo5 9 50 infection infection NN cord-312743-9e4yufo5 9 51 by by IN cord-312743-9e4yufo5 9 52 blocking block VBG cord-312743-9e4yufo5 9 53 virus virus NN cord-312743-9e4yufo5 9 54 attachment attachment NN cord-312743-9e4yufo5 9 55 and and CC cord-312743-9e4yufo5 9 56 entry entry NN cord-312743-9e4yufo5 9 57 . . . cord-312743-9e4yufo5 10 1 Moreover moreover RB cord-312743-9e4yufo5 10 2 , , , cord-312743-9e4yufo5 10 3 blood blood NN cord-312743-9e4yufo5 10 4 group group NN cord-312743-9e4yufo5 10 5 O o NN cord-312743-9e4yufo5 10 6 individuals individual NNS cord-312743-9e4yufo5 10 7 were be VBD cord-312743-9e4yufo5 10 8 at at IN cord-312743-9e4yufo5 10 9 a a DT cord-312743-9e4yufo5 10 10 much much RB cord-312743-9e4yufo5 10 11 lower low JJR cord-312743-9e4yufo5 10 12 risk risk NN cord-312743-9e4yufo5 10 13 of of IN cord-312743-9e4yufo5 10 14 being be VBG cord-312743-9e4yufo5 10 15 infected infect VBN cord-312743-9e4yufo5 10 16 than than IN cord-312743-9e4yufo5 10 17 non non JJ cord-312743-9e4yufo5 10 18 - - JJ cord-312743-9e4yufo5 10 19 O o JJ cord-312743-9e4yufo5 10 20 individuals individual NNS cord-312743-9e4yufo5 10 21 in in IN cord-312743-9e4yufo5 10 22 a a DT cord-312743-9e4yufo5 10 23 Hong Hong NNP cord-312743-9e4yufo5 10 24 Kong Kong NNP cord-312743-9e4yufo5 10 25 2003 2003 CD cord-312743-9e4yufo5 10 26 SARS SARS NNP cord-312743-9e4yufo5 10 27 hospital hospital NN cord-312743-9e4yufo5 10 28 outbreak outbreak NN cord-312743-9e4yufo5 10 29 [ [ -LRB- cord-312743-9e4yufo5 10 30 15 15 CD cord-312743-9e4yufo5 10 31 ] ] -RRB- cord-312743-9e4yufo5 10 32 , , , cord-312743-9e4yufo5 10 33 and and CC cord-312743-9e4yufo5 10 34 a a DT cord-312743-9e4yufo5 10 35 similar similar JJ cord-312743-9e4yufo5 10 36 trend trend NN cord-312743-9e4yufo5 10 37 has have VBZ cord-312743-9e4yufo5 10 38 just just RB cord-312743-9e4yufo5 10 39 been be VBN cord-312743-9e4yufo5 10 40 observed observe VBN cord-312743-9e4yufo5 10 41 for for IN cord-312743-9e4yufo5 10 42 COVID-19 COVID-19 NNP cord-312743-9e4yufo5 10 43 in in IN cord-312743-9e4yufo5 10 44 China China NNP cord-312743-9e4yufo5 10 45 [ [ -LRB- cord-312743-9e4yufo5 10 46 16 16 CD cord-312743-9e4yufo5 10 47 ] ] -RRB- cord-312743-9e4yufo5 10 48 . . . cord-312743-9e4yufo5 11 1 Accordingly accordingly RB cord-312743-9e4yufo5 11 2 , , , cord-312743-9e4yufo5 11 3 blood blood NN cord-312743-9e4yufo5 11 4 group group NN cord-312743-9e4yufo5 11 5 O o NN cord-312743-9e4yufo5 11 6 individuals individual NNS cord-312743-9e4yufo5 11 7 would would MD cord-312743-9e4yufo5 11 8 be be VB cord-312743-9e4yufo5 11 9 at at IN cord-312743-9e4yufo5 11 10 a a DT cord-312743-9e4yufo5 11 11 lesser less JJR cord-312743-9e4yufo5 11 12 risk risk NN cord-312743-9e4yufo5 11 13 of of IN cord-312743-9e4yufo5 11 14 being be VBG cord-312743-9e4yufo5 11 15 infected infect VBN cord-312743-9e4yufo5 11 16 than than IN cord-312743-9e4yufo5 11 17 non non JJ cord-312743-9e4yufo5 11 18 - - JJ cord-312743-9e4yufo5 11 19 O o JJ cord-312743-9e4yufo5 11 20 individuals individual NNS cord-312743-9e4yufo5 11 21 due due JJ cord-312743-9e4yufo5 11 22 to to IN cord-312743-9e4yufo5 11 23 blocking block VBG cord-312743-9e4yufo5 11 24 of of IN cord-312743-9e4yufo5 11 25 potential potential JJ cord-312743-9e4yufo5 11 26 transmission transmission NN cord-312743-9e4yufo5 11 27 events event NNS cord-312743-9e4yufo5 11 28 from from IN cord-312743-9e4yufo5 11 29 either either CC cord-312743-9e4yufo5 11 30 A A NNP cord-312743-9e4yufo5 11 31 , , , cord-312743-9e4yufo5 11 32 B b NN cord-312743-9e4yufo5 11 33 , , , cord-312743-9e4yufo5 11 34 or or CC cord-312743-9e4yufo5 11 35 AB AB NNP cord-312743-9e4yufo5 11 36 individuals individual NNS cord-312743-9e4yufo5 11 37 , , , cord-312743-9e4yufo5 11 38 providing provide VBG cord-312743-9e4yufo5 12 1 anti anti JJ cord-312743-9e4yufo5 12 2 - - NNP cord-312743-9e4yufo5 12 3 A a JJ cord-312743-9e4yufo5 12 4 or or CC cord-312743-9e4yufo5 12 5 anti anti JJ cord-312743-9e4yufo5 12 6 - - JJ cord-312743-9e4yufo5 12 7 B b JJ cord-312743-9e4yufo5 12 8 titers titer NNS cord-312743-9e4yufo5 12 9 are be VBP cord-312743-9e4yufo5 12 10 of of IN cord-312743-9e4yufo5 12 11 sufficient sufficient JJ cord-312743-9e4yufo5 12 12 magnitude magnitude NN cord-312743-9e4yufo5 12 13 ( ( -LRB- cord-312743-9e4yufo5 12 14 Fig Fig NNP cord-312743-9e4yufo5 12 15 1 1 CD cord-312743-9e4yufo5 12 16 ) ) -RRB- cord-312743-9e4yufo5 12 17 . . . cord-312743-9e4yufo5 13 1 Mathematical mathematical JJ cord-312743-9e4yufo5 13 2 modeling modeling NN cord-312743-9e4yufo5 13 3 of of IN cord-312743-9e4yufo5 13 4 the the DT cord-312743-9e4yufo5 13 5 consequences consequence NNS cord-312743-9e4yufo5 13 6 of of IN cord-312743-9e4yufo5 13 7 this this DT cord-312743-9e4yufo5 13 8 potential potential JJ cord-312743-9e4yufo5 13 9 limitation limitation NN cord-312743-9e4yufo5 13 10 of of IN cord-312743-9e4yufo5 13 11 virus virus NN cord-312743-9e4yufo5 13 12 transmission transmission NN cord-312743-9e4yufo5 13 13 suggested suggest VBD cord-312743-9e4yufo5 13 14 that that IN cord-312743-9e4yufo5 13 15 the the DT cord-312743-9e4yufo5 13 16 Hong Hong NNP cord-312743-9e4yufo5 13 17 Kong Kong NNP cord-312743-9e4yufo5 13 18 SARS SARS NNP cord-312743-9e4yufo5 13 19 hospital hospital NN cord-312743-9e4yufo5 13 20 outbreak outbreak NN cord-312743-9e4yufo5 13 21 had have VBD cord-312743-9e4yufo5 13 22 been be VBN cord-312743-9e4yufo5 13 23 slowed slow VBN cord-312743-9e4yufo5 13 24 down down RP cord-312743-9e4yufo5 13 25 to to IN cord-312743-9e4yufo5 13 26 some some DT cord-312743-9e4yufo5 13 27 extent extent NN cord-312743-9e4yufo5 13 28 thanks thank NNS cord-312743-9e4yufo5 13 29 to to IN cord-312743-9e4yufo5 13 30 the the DT cord-312743-9e4yufo5 13 31 ABO ABO NNP cord-312743-9e4yufo5 13 32 genetic genetic JJ cord-312743-9e4yufo5 13 33 polymorphism polymorphism NN cord-312743-9e4yufo5 13 34 and and CC cord-312743-9e4yufo5 13 35 the the DT cord-312743-9e4yufo5 13 36 ensuing ensue VBG cord-312743-9e4yufo5 13 37 neutralizing neutralize VBG cord-312743-9e4yufo5 13 38 anti anti JJ cord-312743-9e4yufo5 13 39 - - JJ cord-312743-9e4yufo5 13 40 A a JJ cord-312743-9e4yufo5 13 41 and and CC cord-312743-9e4yufo5 13 42 anti anti JJ cord-312743-9e4yufo5 13 43 - - JJ cord-312743-9e4yufo5 13 44 B b JJ cord-312743-9e4yufo5 13 45 antibodies antibody NNS cord-312743-9e4yufo5 13 46 . . . cord-312743-9e4yufo5 14 1 It -PRON- PRP cord-312743-9e4yufo5 14 2 further further RB cord-312743-9e4yufo5 14 3 indicated indicate VBD cord-312743-9e4yufo5 14 4 that that IN cord-312743-9e4yufo5 14 5 if if IN cord-312743-9e4yufo5 14 6 anti anti JJ cord-312743-9e4yufo5 14 7 - - JJ cord-312743-9e4yufo5 14 8 blood blood JJ cord-312743-9e4yufo5 14 9 group group NN cord-312743-9e4yufo5 14 10 A A NNP cord-312743-9e4yufo5 14 11 and/ and/ CD cord-312743-9e4yufo5 14 12 or or CC cord-312743-9e4yufo5 14 13 B b NN cord-312743-9e4yufo5 14 14 titers titer NNS cord-312743-9e4yufo5 14 15 had have VBD cord-312743-9e4yufo5 14 16 always always RB cord-312743-9e4yufo5 14 17 been be VBN cord-312743-9e4yufo5 14 18 high high JJ cord-312743-9e4yufo5 14 19 , , , cord-312743-9e4yufo5 14 20 transmission transmission NN cord-312743-9e4yufo5 14 21 of of IN cord-312743-9e4yufo5 14 22 the the DT cord-312743-9e4yufo5 14 23 virus virus NN cord-312743-9e4yufo5 14 24 , , , cord-312743-9e4yufo5 14 25 in in IN cord-312743-9e4yufo5 14 26 the the DT cord-312743-9e4yufo5 14 27 absence absence NN cord-312743-9e4yufo5 14 28 of of IN cord-312743-9e4yufo5 14 29 any any DT cord-312743-9e4yufo5 14 30 containment containment NN cord-312743-9e4yufo5 14 31 measure measure NN cord-312743-9e4yufo5 14 32 , , , cord-312743-9e4yufo5 14 33 would would MD cord-312743-9e4yufo5 14 34 be be VB cord-312743-9e4yufo5 14 35 largely largely RB cord-312743-9e4yufo5 14 36 impaired impaired JJ cord-312743-9e4yufo5 14 37 and and CC cord-312743-9e4yufo5 14 38 the the DT cord-312743-9e4yufo5 14 39 outbreak outbreak NN cord-312743-9e4yufo5 14 40 slowed slow VBD cord-312743-9e4yufo5 14 41 to to IN cord-312743-9e4yufo5 14 42 a a DT cord-312743-9e4yufo5 14 43 considerable considerable JJ cord-312743-9e4yufo5 14 44 extent extent NN cord-312743-9e4yufo5 14 45 [ [ -LRB- cord-312743-9e4yufo5 14 46 14 14 CD cord-312743-9e4yufo5 14 47 ] ] -RRB- cord-312743-9e4yufo5 14 48 . . . cord-312743-9e4yufo5 15 1 We -PRON- PRP cord-312743-9e4yufo5 15 2 therefore therefore RB cord-312743-9e4yufo5 15 3 hypothesize hypothesize VBP cord-312743-9e4yufo5 15 4 that that IN cord-312743-9e4yufo5 15 5 as as IN cord-312743-9e4yufo5 15 6 they -PRON- PRP cord-312743-9e4yufo5 15 7 are be VBP cord-312743-9e4yufo5 15 8 produced produce VBN cord-312743-9e4yufo5 15 9 in in IN cord-312743-9e4yufo5 15 10 cells cell NNS cord-312743-9e4yufo5 15 11 coexpressing coexpresse VBG cord-312743-9e4yufo5 15 12 the the DT cord-312743-9e4yufo5 15 13 ACE2 ACE2 NNP cord-312743-9e4yufo5 15 14 receptor receptor NN cord-312743-9e4yufo5 15 15 and and CC cord-312743-9e4yufo5 16 1 either either CC cord-312743-9e4yufo5 16 2 the the DT cord-312743-9e4yufo5 16 3 αGal αGal NNPS cord-312743-9e4yufo5 16 4 , , , cord-312743-9e4yufo5 16 5 NeuGc neugc UH cord-312743-9e4yufo5 16 6 , , , cord-312743-9e4yufo5 16 7 or or CC cord-312743-9e4yufo5 16 8 A a NN cord-312743-9e4yufo5 16 9 / / SYM cord-312743-9e4yufo5 16 10 B b NN cord-312743-9e4yufo5 16 11 blood blood NN cord-312743-9e4yufo5 16 12 group group NN cord-312743-9e4yufo5 16 13 antigens antigen NNS cord-312743-9e4yufo5 16 14 , , , cord-312743-9e4yufo5 16 15 both both DT cord-312743-9e4yufo5 16 16 SARS SARS NNP cord-312743-9e4yufo5 16 17 - - HYPH cord-312743-9e4yufo5 16 18 CoV CoV NNP cord-312743-9e4yufo5 16 19 and and CC cord-312743-9e4yufo5 16 20 SARS SARS NNP cord-312743-9e4yufo5 16 21 - - HYPH cord-312743-9e4yufo5 16 22 CoV2 CoV2 NNP cord-312743-9e4yufo5 16 23 harbor harbor VBP cord-312743-9e4yufo5 16 24 the the DT cord-312743-9e4yufo5 16 25 corresponding correspond VBG cord-312743-9e4yufo5 16 26 glycan glycan NN cord-312743-9e4yufo5 16 27 epitopes epitope NNS cord-312743-9e4yufo5 16 28 . . . cord-312743-9e4yufo5 17 1 Because because IN cord-312743-9e4yufo5 17 2 of of IN cord-312743-9e4yufo5 17 3 the the DT cord-312743-9e4yufo5 17 4 natural natural JJ cord-312743-9e4yufo5 17 5 immune immune JJ cord-312743-9e4yufo5 17 6 response response NN cord-312743-9e4yufo5 17 7 against against IN cord-312743-9e4yufo5 17 8 these these DT cord-312743-9e4yufo5 17 9 epitopes epitope NNS cord-312743-9e4yufo5 17 10 , , , cord-312743-9e4yufo5 17 11 the the DT cord-312743-9e4yufo5 17 12 αGal αGal NNPS cord-312743-9e4yufo5 17 13 and and CC cord-312743-9e4yufo5 17 14 NeuGc NeuGc NNP cord-312743-9e4yufo5 17 15 xenoantigens xenoantigens NNP cord-312743-9e4yufo5 17 16 would would MD cord-312743-9e4yufo5 17 17 contribute contribute VB cord-312743-9e4yufo5 17 18 to to TO cord-312743-9e4yufo5 17 19 prevent prevent VB cord-312743-9e4yufo5 17 20 cross cross JJ cord-312743-9e4yufo5 17 21 - - JJ cord-312743-9e4yufo5 17 22 species species JJ cord-312743-9e4yufo5 17 23 transmission transmission NN cord-312743-9e4yufo5 17 24 from from IN cord-312743-9e4yufo5 17 25 nonprimate nonprimate NN cord-312743-9e4yufo5 17 26 mammals mammal NNS cord-312743-9e4yufo5 17 27 to to IN cord-312743-9e4yufo5 17 28 humans human NNS cord-312743-9e4yufo5 17 29 , , , cord-312743-9e4yufo5 17 30 while while IN cord-312743-9e4yufo5 17 31 A a NN cord-312743-9e4yufo5 17 32 / / SYM cord-312743-9e4yufo5 17 33 B b NN cord-312743-9e4yufo5 17 34 blood blood NN cord-312743-9e4yufo5 17 35 group group NN cord-312743-9e4yufo5 17 36 antigens antigen NNS cord-312743-9e4yufo5 17 37 would would MD cord-312743-9e4yufo5 17 38 contribute contribute VB cord-312743-9e4yufo5 17 39 to to TO cord-312743-9e4yufo5 17 40 decrease decrease VB cord-312743-9e4yufo5 17 41 and and CC cord-312743-9e4yufo5 17 42 slow slow JJ cord-312743-9e4yufo5 17 43 between between IN cord-312743-9e4yufo5 17 44 - - HYPH cord-312743-9e4yufo5 17 45 human human JJ cord-312743-9e4yufo5 17 46 transmission transmission NN cord-312743-9e4yufo5 17 47 . . . cord-312743-9e4yufo5 18 1 Nonetheless nonetheless RB cord-312743-9e4yufo5 18 2 , , , cord-312743-9e4yufo5 18 3 owing owe VBG cord-312743-9e4yufo5 18 4 to to IN cord-312743-9e4yufo5 18 5 the the DT cord-312743-9e4yufo5 18 6 presence presence NN cord-312743-9e4yufo5 18 7 of of IN cord-312743-9e4yufo5 18 8 individuals individual NNS cord-312743-9e4yufo5 18 9 with with IN cord-312743-9e4yufo5 18 10 low low JJ cord-312743-9e4yufo5 18 11 anti anti JJ cord-312743-9e4yufo5 18 12 - - JJ cord-312743-9e4yufo5 18 13 αGal αgal JJ cord-312743-9e4yufo5 18 14 titers titer NNS cord-312743-9e4yufo5 18 15 , , , cord-312743-9e4yufo5 18 16 occasional occasional JJ cord-312743-9e4yufo5 18 17 cross cross JJ cord-312743-9e4yufo5 18 18 - - JJ cord-312743-9e4yufo5 18 19 species species JJ cord-312743-9e4yufo5 18 20 transmission transmission NN cord-312743-9e4yufo5 18 21 may may MD cord-312743-9e4yufo5 18 22 occur occur VB cord-312743-9e4yufo5 18 23 . . . cord-312743-9e4yufo5 19 1 Interestingly interestingly RB cord-312743-9e4yufo5 19 2 , , , cord-312743-9e4yufo5 19 3 a a DT cord-312743-9e4yufo5 19 4 recent recent JJ cord-312743-9e4yufo5 19 5 genomic genomic JJ cord-312743-9e4yufo5 19 6 analysis analysis NN cord-312743-9e4yufo5 19 7 across across IN cord-312743-9e4yufo5 19 8 vertebrates vertebrate NNS cord-312743-9e4yufo5 19 9 revealed reveal VBD cord-312743-9e4yufo5 19 10 that that IN cord-312743-9e4yufo5 19 11 two two CD cord-312743-9e4yufo5 19 12 bats bat NNS cord-312743-9e4yufo5 19 13 lineages lineage NNS cord-312743-9e4yufo5 19 14 , , , cord-312743-9e4yufo5 19 15 including include VBG cord-312743-9e4yufo5 19 16 Rhinopholus Rhinopholus NNP cord-312743-9e4yufo5 19 17 bats bat NNS cord-312743-9e4yufo5 19 18 suspected suspect VBN cord-312743-9e4yufo5 19 19 to to TO cord-312743-9e4yufo5 19 20 have have VB cord-312743-9e4yufo5 19 21 originated originate VBN cord-312743-9e4yufo5 19 22 the the DT cord-312743-9e4yufo5 19 23 SARS SARS NNP cord-312743-9e4yufo5 19 24 - - HYPH cord-312743-9e4yufo5 19 25 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 19 26 closest close JJS cord-312743-9e4yufo5 19 27 ancestor ancestor NN cord-312743-9e4yufo5 19 28 , , , cord-312743-9e4yufo5 19 29 lost lose VBD cord-312743-9e4yufo5 19 30 their -PRON- PRP$ cord-312743-9e4yufo5 19 31 Cmah Cmah NNP cord-312743-9e4yufo5 19 32 gene gene NN cord-312743-9e4yufo5 19 33 function function NN cord-312743-9e4yufo5 19 34 , , , cord-312743-9e4yufo5 19 35 similar similar JJ cord-312743-9e4yufo5 19 36 to to IN cord-312743-9e4yufo5 19 37 humans human NNS cord-312743-9e4yufo5 19 38 [ [ -LRB- cord-312743-9e4yufo5 19 39 17 17 CD cord-312743-9e4yufo5 19 40 ] ] -RRB- cord-312743-9e4yufo5 19 41 . . . cord-312743-9e4yufo5 20 1 The the DT cord-312743-9e4yufo5 20 2 lack lack NN cord-312743-9e4yufo5 20 3 of of IN cord-312743-9e4yufo5 20 4 NeuGc NeuGc NNP cord-312743-9e4yufo5 20 5 xenoantigen xenoantigen NNP cord-312743-9e4yufo5 20 6 on on IN cord-312743-9e4yufo5 20 7 the the DT cord-312743-9e4yufo5 20 8 virions virion NNS cord-312743-9e4yufo5 20 9 produced produce VBN cord-312743-9e4yufo5 20 10 by by IN cord-312743-9e4yufo5 20 11 these these DT cord-312743-9e4yufo5 20 12 bats bat NNS cord-312743-9e4yufo5 20 13 might may MD cord-312743-9e4yufo5 20 14 have have VB cord-312743-9e4yufo5 20 15 facilitated facilitate VBN cord-312743-9e4yufo5 20 16 cross cross JJ cord-312743-9e4yufo5 20 17 - - JJ cord-312743-9e4yufo5 20 18 species species JJ cord-312743-9e4yufo5 20 19 transmission transmission NN cord-312743-9e4yufo5 20 20 . . . cord-312743-9e4yufo5 21 1 Likewise likewise RB cord-312743-9e4yufo5 21 2 , , , cord-312743-9e4yufo5 21 3 impairment impairment NN cord-312743-9e4yufo5 21 4 of of IN cord-312743-9e4yufo5 21 5 transmission transmission NN cord-312743-9e4yufo5 21 6 by by IN cord-312743-9e4yufo5 21 7 the the DT cord-312743-9e4yufo5 21 8 anti anti JJ cord-312743-9e4yufo5 21 9 - - JJ cord-312743-9e4yufo5 21 10 blood blood JJ cord-312743-9e4yufo5 21 11 group group NN cord-312743-9e4yufo5 21 12 antibodies antibody NNS cord-312743-9e4yufo5 21 13 may may MD cord-312743-9e4yufo5 21 14 not not RB cord-312743-9e4yufo5 21 15 work work VB cord-312743-9e4yufo5 21 16 to to IN cord-312743-9e4yufo5 21 17 its -PRON- PRP$ cord-312743-9e4yufo5 21 18 full full JJ cord-312743-9e4yufo5 21 19 potential potential NN cord-312743-9e4yufo5 21 20 because because IN cord-312743-9e4yufo5 21 21 of of IN cord-312743-9e4yufo5 21 22 their -PRON- PRP$ cord-312743-9e4yufo5 21 23 variable variable JJ cord-312743-9e4yufo5 21 24 titers titer NNS cord-312743-9e4yufo5 21 25 in in IN cord-312743-9e4yufo5 21 26 the the DT cord-312743-9e4yufo5 21 27 population population NN cord-312743-9e4yufo5 21 28 and and CC cord-312743-9e4yufo5 21 29 of of IN cord-312743-9e4yufo5 21 30 the the DT cord-312743-9e4yufo5 21 31 high high JJ cord-312743-9e4yufo5 21 32 affinity affinity NN cord-312743-9e4yufo5 21 33 of of IN cord-312743-9e4yufo5 21 34 the the DT cord-312743-9e4yufo5 21 35 SARS SARS NNP cord-312743-9e4yufo5 21 36 - - HYPH cord-312743-9e4yufo5 21 37 CoV2 CoV2 NNP cord-312743-9e4yufo5 21 38 for for IN cord-312743-9e4yufo5 21 39 ACE2 ACE2 NNP cord-312743-9e4yufo5 21 40 [ [ -LRB- cord-312743-9e4yufo5 21 41 18 18 CD cord-312743-9e4yufo5 21 42 ] ] -RRB- cord-312743-9e4yufo5 21 43 , , , cord-312743-9e4yufo5 21 44 rendering render VBG cord-312743-9e4yufo5 21 45 its -PRON- PRP$ cord-312743-9e4yufo5 21 46 neutralization neutralization NN cord-312743-9e4yufo5 21 47 more more RBR cord-312743-9e4yufo5 21 48 difficult difficult JJ cord-312743-9e4yufo5 21 49 . . . cord-312743-9e4yufo5 22 1 This this DT cord-312743-9e4yufo5 22 2 leaves leave VBZ cord-312743-9e4yufo5 22 3 room room NN cord-312743-9e4yufo5 22 4 to to TO cord-312743-9e4yufo5 22 5 amplify amplify VB cord-312743-9e4yufo5 22 6 these these DT cord-312743-9e4yufo5 22 7 innate innate JJ cord-312743-9e4yufo5 22 8 mechanisms mechanism NNS cord-312743-9e4yufo5 22 9 of of IN cord-312743-9e4yufo5 22 10 protection protection NN cord-312743-9e4yufo5 22 11 in in IN cord-312743-9e4yufo5 22 12 preparation preparation NN cord-312743-9e4yufo5 22 13 for for IN cord-312743-9e4yufo5 22 14 the the DT cord-312743-9e4yufo5 22 15 next next JJ cord-312743-9e4yufo5 22 16 emergence emergence NN cord-312743-9e4yufo5 22 17 and and CC cord-312743-9e4yufo5 22 18 mitigation mitigation NN cord-312743-9e4yufo5 22 19 of of IN cord-312743-9e4yufo5 22 20 the the DT cord-312743-9e4yufo5 22 21 virus virus NN cord-312743-9e4yufo5 22 22 impact impact NN cord-312743-9e4yufo5 22 23 once once IN cord-312743-9e4yufo5 22 24 emergence emergence NN cord-312743-9e4yufo5 22 25 has have VBZ cord-312743-9e4yufo5 22 26 occurred occur VBN cord-312743-9e4yufo5 22 27 . . . cord-312743-9e4yufo5 23 1 If if IN cord-312743-9e4yufo5 23 2 the the DT cord-312743-9e4yufo5 23 3 antibody antibody NN cord-312743-9e4yufo5 23 4 blocking block VBG cord-312743-9e4yufo5 23 5 effect effect NN cord-312743-9e4yufo5 23 6 can can MD cord-312743-9e4yufo5 23 7 be be VB cord-312743-9e4yufo5 23 8 documented document VBN cord-312743-9e4yufo5 23 9 in in IN cord-312743-9e4yufo5 23 10 vitro vitro FW cord-312743-9e4yufo5 23 11 , , , cord-312743-9e4yufo5 23 12 and and CC cord-312743-9e4yufo5 23 13 possibly possibly RB cord-312743-9e4yufo5 23 14 in in IN cord-312743-9e4yufo5 23 15 vivo vivo NNP cord-312743-9e4yufo5 23 16 , , , cord-312743-9e4yufo5 23 17 it -PRON- PRP cord-312743-9e4yufo5 23 18 will will MD cord-312743-9e4yufo5 23 19 become become VB cord-312743-9e4yufo5 23 20 important important JJ cord-312743-9e4yufo5 23 21 to to TO cord-312743-9e4yufo5 23 22 consider consider VB cord-312743-9e4yufo5 23 23 raising raise VBG cord-312743-9e4yufo5 23 24 the the DT cord-312743-9e4yufo5 23 25 anti anti JJ cord-312743-9e4yufo5 23 26 - - JJ cord-312743-9e4yufo5 23 27 αGal αGal NNPS cord-312743-9e4yufo5 23 28 , , , cord-312743-9e4yufo5 23 29 as as RB cord-312743-9e4yufo5 23 30 well well RB cord-312743-9e4yufo5 23 31 as as IN cord-312743-9e4yufo5 23 32 the the DT cord-312743-9e4yufo5 23 33 anti anti JJ cord-312743-9e4yufo5 23 34 - - JJ cord-312743-9e4yufo5 23 35 A a JJ cord-312743-9e4yufo5 23 36 and and CC cord-312743-9e4yufo5 23 37 anti anti JJ cord-312743-9e4yufo5 23 38 - - JJ cord-312743-9e4yufo5 23 39 B b JJ cord-312743-9e4yufo5 23 40 antibodies antibody NNS cord-312743-9e4yufo5 23 41 titers titer NNS cord-312743-9e4yufo5 23 42 in in IN cord-312743-9e4yufo5 23 43 human human JJ cord-312743-9e4yufo5 23 44 populations population NNS cord-312743-9e4yufo5 23 45 . . . cord-312743-9e4yufo5 24 1 That that DT cord-312743-9e4yufo5 24 2 could could MD cord-312743-9e4yufo5 24 3 be be VB cord-312743-9e4yufo5 24 4 achieved achieve VBN cord-312743-9e4yufo5 24 5 as as RB cord-312743-9e4yufo5 24 6 previously previously RB cord-312743-9e4yufo5 24 7 described describe VBN cord-312743-9e4yufo5 24 8 either either CC cord-312743-9e4yufo5 24 9 by by IN cord-312743-9e4yufo5 24 10 immunizing immunize VBG cord-312743-9e4yufo5 24 11 against against IN cord-312743-9e4yufo5 24 12 inactivated inactivate VBN cord-312743-9e4yufo5 24 13 harmless harmless JJ cord-312743-9e4yufo5 24 14 bacteria bacteria NNS cord-312743-9e4yufo5 24 15 that that WDT cord-312743-9e4yufo5 24 16 harbor harbor VBP cord-312743-9e4yufo5 24 17 the the DT cord-312743-9e4yufo5 24 18 αGal αGal NNPS cord-312743-9e4yufo5 24 19 , , , cord-312743-9e4yufo5 24 20 A A NNP cord-312743-9e4yufo5 24 21 , , , cord-312743-9e4yufo5 24 22 and and CC cord-312743-9e4yufo5 24 23 B b NN cord-312743-9e4yufo5 24 24 epitopes epitope NNS cord-312743-9e4yufo5 24 25 or or CC cord-312743-9e4yufo5 24 26 by by IN cord-312743-9e4yufo5 24 27 immunizing immunize VBG cord-312743-9e4yufo5 24 28 against against IN cord-312743-9e4yufo5 24 29 the the DT cord-312743-9e4yufo5 24 30 corresponding corresponding JJ cord-312743-9e4yufo5 24 31 synthetic synthetic JJ cord-312743-9e4yufo5 24 32 oligosaccharides oligosaccharide NNS cord-312743-9e4yufo5 24 33 linked link VBN cord-312743-9e4yufo5 24 34 to to IN cord-312743-9e4yufo5 24 35 an an DT cord-312743-9e4yufo5 24 36 immunogenic immunogenic JJ cord-312743-9e4yufo5 24 37 scaffold scaffold NN cord-312743-9e4yufo5 24 38 [ [ -LRB- cord-312743-9e4yufo5 24 39 19 19 CD cord-312743-9e4yufo5 24 40 , , , cord-312743-9e4yufo5 24 41 20 20 CD cord-312743-9e4yufo5 24 42 ] ] -RRB- cord-312743-9e4yufo5 24 43 . . . cord-312743-9e4yufo5 25 1 Raising raise VBG cord-312743-9e4yufo5 25 2 the the DT cord-312743-9e4yufo5 25 3 anti anti JJ cord-312743-9e4yufo5 25 4 - - JJ cord-312743-9e4yufo5 25 5 A a JJ cord-312743-9e4yufo5 25 6 and and CC cord-312743-9e4yufo5 25 7 anti anti JJ cord-312743-9e4yufo5 25 8 - - JJ cord-312743-9e4yufo5 25 9 B b JJ cord-312743-9e4yufo5 25 10 titers titer NNS cord-312743-9e4yufo5 25 11 in in IN cord-312743-9e4yufo5 25 12 the the DT cord-312743-9e4yufo5 25 13 whole whole JJ cord-312743-9e4yufo5 25 14 population population NN cord-312743-9e4yufo5 25 15 carries carry VBZ cord-312743-9e4yufo5 25 16 the the DT cord-312743-9e4yufo5 25 17 risk risk NN cord-312743-9e4yufo5 25 18 of of IN cord-312743-9e4yufo5 25 19 complicating complicate VBG cord-312743-9e4yufo5 25 20 incompatible incompatible JJ cord-312743-9e4yufo5 25 21 platelet platelet NN cord-312743-9e4yufo5 25 22 transfusion transfusion NN cord-312743-9e4yufo5 25 23 as as RB cord-312743-9e4yufo5 25 24 well well RB cord-312743-9e4yufo5 25 25 as as IN cord-312743-9e4yufo5 25 26 increasing increase VBG cord-312743-9e4yufo5 25 27 the the DT cord-312743-9e4yufo5 25 28 risk risk NN cord-312743-9e4yufo5 25 29 of of IN cord-312743-9e4yufo5 25 30 hemolytic hemolytic JJ cord-312743-9e4yufo5 25 31 disease disease NN cord-312743-9e4yufo5 25 32 of of IN cord-312743-9e4yufo5 25 33 the the DT cord-312743-9e4yufo5 25 34 newborn newborn NN cord-312743-9e4yufo5 25 35 in in IN cord-312743-9e4yufo5 25 36 case case NN cord-312743-9e4yufo5 25 37 of of IN cord-312743-9e4yufo5 25 38 mother mother NN cord-312743-9e4yufo5 25 39 - - HYPH cord-312743-9e4yufo5 25 40 infant infant NN cord-312743-9e4yufo5 25 41 ABO ABO NNP cord-312743-9e4yufo5 25 42 incompatibility incompatibility NN cord-312743-9e4yufo5 25 43 . . . cord-312743-9e4yufo5 26 1 These these DT cord-312743-9e4yufo5 26 2 issues issue NNS cord-312743-9e4yufo5 26 3 should should MD cord-312743-9e4yufo5 26 4 be be VB cord-312743-9e4yufo5 26 5 carefully carefully RB cord-312743-9e4yufo5 26 6 dealt deal VBN cord-312743-9e4yufo5 26 7 with with IN cord-312743-9e4yufo5 26 8 . . . cord-312743-9e4yufo5 27 1 Raising raise VBG cord-312743-9e4yufo5 27 2 the the DT cord-312743-9e4yufo5 27 3 anti anti JJ cord-312743-9e4yufo5 27 4 - - JJ cord-312743-9e4yufo5 27 5 NeuGc neugc JJ cord-312743-9e4yufo5 27 6 titers titer NNS cord-312743-9e4yufo5 27 7 might may MD cord-312743-9e4yufo5 27 8 be be VB cord-312743-9e4yufo5 27 9 more more RBR cord-312743-9e4yufo5 27 10 problematic problematic JJ cord-312743-9e4yufo5 27 11 since since IN cord-312743-9e4yufo5 27 12 meat meat NN cord-312743-9e4yufo5 27 13 and and CC cord-312743-9e4yufo5 27 14 dairy dairy NN cord-312743-9e4yufo5 27 15 products product NNS cord-312743-9e4yufo5 27 16 consumption consumption NN cord-312743-9e4yufo5 27 17 allows allow VBZ cord-312743-9e4yufo5 27 18 incorporation incorporation NN cord-312743-9e4yufo5 27 19 of of IN cord-312743-9e4yufo5 27 20 NeuGc neugc RB cord-312743-9e4yufo5 27 21 onto onto IN cord-312743-9e4yufo5 27 22 human human JJ cord-312743-9e4yufo5 27 23 glycans glycan NNS cord-312743-9e4yufo5 27 24 , , , cord-312743-9e4yufo5 27 25 and and CC cord-312743-9e4yufo5 27 26 this this DT cord-312743-9e4yufo5 27 27 may may MD cord-312743-9e4yufo5 27 28 contribute contribute VB cord-312743-9e4yufo5 27 29 to to IN cord-312743-9e4yufo5 27 30 the the DT cord-312743-9e4yufo5 27 31 promotion promotion NN cord-312743-9e4yufo5 27 32 of of IN cord-312743-9e4yufo5 27 33 inflammation inflammation NN cord-312743-9e4yufo5 27 34 and and CC cord-312743-9e4yufo5 27 35 cancer cancer NN cord-312743-9e4yufo5 27 36 progression progression NN cord-312743-9e4yufo5 27 37 as as IN cord-312743-9e4yufo5 27 38 experimentally experimentally RB cord-312743-9e4yufo5 27 39 demonstrated demonstrate VBN cord-312743-9e4yufo5 27 40 [ [ -LRB- cord-312743-9e4yufo5 27 41 3 3 CD cord-312743-9e4yufo5 27 42 , , , cord-312743-9e4yufo5 27 43 21 21 CD cord-312743-9e4yufo5 27 44 ] ] -RRB- cord-312743-9e4yufo5 27 45 . . . cord-312743-9e4yufo5 28 1 By by IN cord-312743-9e4yufo5 28 2 contrast contrast NN cord-312743-9e4yufo5 28 3 , , , cord-312743-9e4yufo5 28 4 raising raise VBG cord-312743-9e4yufo5 28 5 the the DT cord-312743-9e4yufo5 28 6 anti anti JJ cord-312743-9e4yufo5 28 7 - - JJ cord-312743-9e4yufo5 28 8 αGal αgal JJ cord-312743-9e4yufo5 28 9 titers titer NNS cord-312743-9e4yufo5 28 10 should should MD cord-312743-9e4yufo5 28 11 not not RB cord-312743-9e4yufo5 28 12 carry carry VB cord-312743-9e4yufo5 28 13 any any DT cord-312743-9e4yufo5 28 14 risk risk NN cord-312743-9e4yufo5 28 15 since since IN cord-312743-9e4yufo5 28 16 the the DT cord-312743-9e4yufo5 28 17 antigen antigen NN cord-312743-9e4yufo5 28 18 is be VBZ cord-312743-9e4yufo5 28 19 entirely entirely RB cord-312743-9e4yufo5 28 20 absent absent JJ cord-312743-9e4yufo5 28 21 from from IN cord-312743-9e4yufo5 28 22 human human JJ cord-312743-9e4yufo5 28 23 tissues tissue NNS cord-312743-9e4yufo5 28 24 . . . cord-312743-9e4yufo5 29 1 Blood blood NN cord-312743-9e4yufo5 29 2 groups group NNS cord-312743-9e4yufo5 30 1 A a NN cord-312743-9e4yufo5 30 2 and and CC cord-312743-9e4yufo5 30 3 B b NN cord-312743-9e4yufo5 30 4 might may MD cord-312743-9e4yufo5 30 5 also also RB cord-312743-9e4yufo5 30 6 be be VB cord-312743-9e4yufo5 30 7 harnessed harness VBN cord-312743-9e4yufo5 30 8 to to TO cord-312743-9e4yufo5 30 9 increase increase VB cord-312743-9e4yufo5 30 10 the the DT cord-312743-9e4yufo5 30 11 efficacy efficacy NN cord-312743-9e4yufo5 30 12 of of IN cord-312743-9e4yufo5 30 13 SARS SARS NNP cord-312743-9e4yufo5 30 14 - - HYPH cord-312743-9e4yufo5 30 15 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 30 16 vaccines vaccine NNS cord-312743-9e4yufo5 30 17 . . . cord-312743-9e4yufo5 31 1 Indeed indeed RB cord-312743-9e4yufo5 31 2 , , , cord-312743-9e4yufo5 31 3 the the DT cord-312743-9e4yufo5 31 4 virus virus NN cord-312743-9e4yufo5 31 5 spike spike NN cord-312743-9e4yufo5 31 6 proteins protein NNS cord-312743-9e4yufo5 31 7 , , , cord-312743-9e4yufo5 31 8 which which WDT cord-312743-9e4yufo5 31 9 are be VBP cord-312743-9e4yufo5 31 10 the the DT cord-312743-9e4yufo5 31 11 main main JJ cord-312743-9e4yufo5 31 12 target target NN cord-312743-9e4yufo5 31 13 of of IN cord-312743-9e4yufo5 31 14 currently currently RB cord-312743-9e4yufo5 31 15 designed design VBN cord-312743-9e4yufo5 31 16 vaccines vaccine NNS cord-312743-9e4yufo5 31 17 , , , cord-312743-9e4yufo5 31 18 might may MD cord-312743-9e4yufo5 31 19 be be VB cord-312743-9e4yufo5 31 20 produced produce VBN cord-312743-9e4yufo5 31 21 in in IN cord-312743-9e4yufo5 31 22 cells cell NNS cord-312743-9e4yufo5 31 23 that that WDT cord-312743-9e4yufo5 31 24 are be VBP cord-312743-9e4yufo5 31 25 enzymatically enzymatically RB cord-312743-9e4yufo5 31 26 equipped equip VBN cord-312743-9e4yufo5 31 27 to to TO cord-312743-9e4yufo5 31 28 synthetize synthetize VB cord-312743-9e4yufo5 31 29 A A NNP cord-312743-9e4yufo5 31 30 and and CC cord-312743-9e4yufo5 31 31 B b NN cord-312743-9e4yufo5 31 32 antigens antigen NNS cord-312743-9e4yufo5 31 33 so so IN cord-312743-9e4yufo5 31 34 that that IN cord-312743-9e4yufo5 31 35 the the DT cord-312743-9e4yufo5 31 36 vaccine vaccine NN cord-312743-9e4yufo5 31 37 glycoprotein glycoprotein NN cord-312743-9e4yufo5 31 38 will will MD cord-312743-9e4yufo5 31 39 carry carry VB cord-312743-9e4yufo5 31 40 these these DT cord-312743-9e4yufo5 31 41 epitopes epitope NNS cord-312743-9e4yufo5 31 42 . . . cord-312743-9e4yufo5 32 1 In in IN cord-312743-9e4yufo5 32 2 addition addition NN cord-312743-9e4yufo5 32 3 to to IN cord-312743-9e4yufo5 32 4 generating generate VBG cord-312743-9e4yufo5 32 5 neutralizing neutralize VBG cord-312743-9e4yufo5 32 6 anti anti JJ cord-312743-9e4yufo5 32 7 - - JJ cord-312743-9e4yufo5 32 8 S s JJ cord-312743-9e4yufo5 32 9 protein protein NN cord-312743-9e4yufo5 32 10 , , , cord-312743-9e4yufo5 32 11 the the DT cord-312743-9e4yufo5 32 12 vaccine vaccine NN cord-312743-9e4yufo5 32 13 would would MD cord-312743-9e4yufo5 32 14 stimulate stimulate VB cord-312743-9e4yufo5 32 15 anti anti JJ cord-312743-9e4yufo5 32 16 - - JJ cord-312743-9e4yufo5 32 17 A a JJ cord-312743-9e4yufo5 32 18 and and CC cord-312743-9e4yufo5 32 19 anti anti JJ cord-312743-9e4yufo5 32 20 - - JJ cord-312743-9e4yufo5 32 21 B b JJ cord-312743-9e4yufo5 32 22 responses response NNS cord-312743-9e4yufo5 32 23 that that WDT cord-312743-9e4yufo5 32 24 may may MD cord-312743-9e4yufo5 32 25 contribute contribute VB cord-312743-9e4yufo5 32 26 to to IN cord-312743-9e4yufo5 32 27 the the DT cord-312743-9e4yufo5 32 28 vaccine vaccine NN cord-312743-9e4yufo5 32 29 efficacy efficacy NN cord-312743-9e4yufo5 32 30 in in IN cord-312743-9e4yufo5 32 31 all all DT cord-312743-9e4yufo5 32 32 cases case NNS cord-312743-9e4yufo5 32 33 of of IN cord-312743-9e4yufo5 32 34 ABO ABO NNP cord-312743-9e4yufo5 32 35 incompatible incompatible JJ cord-312743-9e4yufo5 32 36 transmissions transmission NNS cord-312743-9e4yufo5 32 37 . . . cord-312743-9e4yufo5 33 1 In in IN cord-312743-9e4yufo5 33 2 conclusion conclusion NN cord-312743-9e4yufo5 33 3 , , , cord-312743-9e4yufo5 33 4 we -PRON- PRP cord-312743-9e4yufo5 33 5 propose propose VBP cord-312743-9e4yufo5 33 6 to to TO cord-312743-9e4yufo5 33 7 enhance enhance VB cord-312743-9e4yufo5 33 8 the the DT cord-312743-9e4yufo5 33 9 innate innate JJ cord-312743-9e4yufo5 33 10 anti anti JJ cord-312743-9e4yufo5 33 11 - - JJ cord-312743-9e4yufo5 33 12 viral viral JJ cord-312743-9e4yufo5 33 13 protection protection NN cord-312743-9e4yufo5 33 14 conferred confer VBN cord-312743-9e4yufo5 33 15 by by IN cord-312743-9e4yufo5 33 16 natural natural JJ cord-312743-9e4yufo5 33 17 anti anti JJ cord-312743-9e4yufo5 33 18 - - JJ cord-312743-9e4yufo5 33 19 glycan glycan JJ cord-312743-9e4yufo5 33 20 antibodies antibody NNS cord-312743-9e4yufo5 33 21 in in IN cord-312743-9e4yufo5 33 22 order order NN cord-312743-9e4yufo5 33 23 to to TO cord-312743-9e4yufo5 33 24 lower lower VB cord-312743-9e4yufo5 33 25 both both CC cord-312743-9e4yufo5 33 26 the the DT cord-312743-9e4yufo5 33 27 risk risk NN cord-312743-9e4yufo5 33 28 of of IN cord-312743-9e4yufo5 33 29 emergence emergence NN cord-312743-9e4yufo5 33 30 of of IN cord-312743-9e4yufo5 33 31 coronaviruses coronaviruse NNS cord-312743-9e4yufo5 33 32 , , , cord-312743-9e4yufo5 33 33 or or CC cord-312743-9e4yufo5 33 34 other other JJ cord-312743-9e4yufo5 33 35 enveloped envelop VBN cord-312743-9e4yufo5 33 36 viruses virus NNS cord-312743-9e4yufo5 33 37 , , , cord-312743-9e4yufo5 33 38 from from IN cord-312743-9e4yufo5 33 39 a a DT cord-312743-9e4yufo5 33 40 nonprimate nonprimate NN cord-312743-9e4yufo5 33 41 mammalian mammalian JJ cord-312743-9e4yufo5 33 42 species specie NNS cord-312743-9e4yufo5 33 43 and and CC cord-312743-9e4yufo5 33 44 the the DT cord-312743-9e4yufo5 33 45 risk risk NN cord-312743-9e4yufo5 33 46 of of IN cord-312743-9e4yufo5 33 47 transmission transmission NN cord-312743-9e4yufo5 33 48 within within IN cord-312743-9e4yufo5 33 49 the the DT cord-312743-9e4yufo5 33 50 human human JJ cord-312743-9e4yufo5 33 51 population population NN cord-312743-9e4yufo5 33 52 . . . cord-312743-9e4yufo5 34 1 This this DT cord-312743-9e4yufo5 34 2 could could MD cord-312743-9e4yufo5 34 3 add add VB cord-312743-9e4yufo5 34 4 - - HYPH cord-312743-9e4yufo5 34 5 up up NN cord-312743-9e4yufo5 34 6 to to IN cord-312743-9e4yufo5 34 7 other other JJ cord-312743-9e4yufo5 34 8 protection protection NN cord-312743-9e4yufo5 34 9 and and CC cord-312743-9e4yufo5 34 10 containment containment NN cord-312743-9e4yufo5 34 11 measures measure NNS cord-312743-9e4yufo5 34 12 , , , cord-312743-9e4yufo5 34 13 mitigating mitigate VBG cord-312743-9e4yufo5 34 14 the the DT cord-312743-9e4yufo5 34 15 impact impact NN cord-312743-9e4yufo5 34 16 of of IN cord-312743-9e4yufo5 34 17 the the DT cord-312743-9e4yufo5 34 18 epidemic epidemic NN cord-312743-9e4yufo5 34 19 . . . cord-312743-9e4yufo5 35 1 Virions virion NNS cord-312743-9e4yufo5 35 2 produced produce VBN cord-312743-9e4yufo5 35 3 by by IN cord-312743-9e4yufo5 35 4 blood blood NN cord-312743-9e4yufo5 35 5 group group NN cord-312743-9e4yufo5 35 6 O o NN cord-312743-9e4yufo5 35 7 individuals individual NNS cord-312743-9e4yufo5 35 8 are be VBP cord-312743-9e4yufo5 35 9 devoid devoid JJ cord-312743-9e4yufo5 35 10 of of IN cord-312743-9e4yufo5 35 11 A a NN cord-312743-9e4yufo5 35 12 or or CC cord-312743-9e4yufo5 35 13 B b NN cord-312743-9e4yufo5 35 14 antigens antigen NNS cord-312743-9e4yufo5 35 15 and and CC cord-312743-9e4yufo5 35 16 can can MD cord-312743-9e4yufo5 35 17 be be VB cord-312743-9e4yufo5 35 18 fully fully RB cord-312743-9e4yufo5 35 19 transmitted transmit VBN cord-312743-9e4yufo5 35 20 regardless regardless RB cord-312743-9e4yufo5 35 21 of of IN cord-312743-9e4yufo5 35 22 the the DT cord-312743-9e4yufo5 35 23 recipient recipient NN cord-312743-9e4yufo5 35 24 blood blood NN cord-312743-9e4yufo5 35 25 type type NN cord-312743-9e4yufo5 35 26 ( ( -LRB- cord-312743-9e4yufo5 35 27 full full JJ cord-312743-9e4yufo5 35 28 arrows arrow NNS cord-312743-9e4yufo5 35 29 ) ) -RRB- cord-312743-9e4yufo5 35 30 . . . cord-312743-9e4yufo5 36 1 Viruses virus NNS cord-312743-9e4yufo5 36 2 produced produce VBN cord-312743-9e4yufo5 36 3 by by IN cord-312743-9e4yufo5 36 4 A a NN cord-312743-9e4yufo5 36 5 and and CC cord-312743-9e4yufo5 36 6 B b NN cord-312743-9e4yufo5 36 7 blood blood NN cord-312743-9e4yufo5 36 8 groups group NNS cord-312743-9e4yufo5 36 9 individuals individual NNS cord-312743-9e4yufo5 36 10 are be VBP cord-312743-9e4yufo5 36 11 decorated decorate VBN cord-312743-9e4yufo5 36 12 by by IN cord-312743-9e4yufo5 36 13 A a NN cord-312743-9e4yufo5 36 14 or or CC cord-312743-9e4yufo5 36 15 B B NNP cord-312743-9e4yufo5 36 16 blood blood NN cord-312743-9e4yufo5 36 17 group group NN cord-312743-9e4yufo5 36 18 epitopes epitope NNS cord-312743-9e4yufo5 36 19 ( ( -LRB- cord-312743-9e4yufo5 36 20 red red JJ cord-312743-9e4yufo5 36 21 and and CC cord-312743-9e4yufo5 36 22 green green JJ cord-312743-9e4yufo5 36 23 spikes spike NNS cord-312743-9e4yufo5 36 24 , , , cord-312743-9e4yufo5 36 25 respectively respectively RB cord-312743-9e4yufo5 36 26 ) ) -RRB- cord-312743-9e4yufo5 36 27 and and CC cord-312743-9e4yufo5 36 28 viruses virus NNS cord-312743-9e4yufo5 36 29 produced produce VBN cord-312743-9e4yufo5 36 30 by by IN cord-312743-9e4yufo5 36 31 blood blood NN cord-312743-9e4yufo5 36 32 group group NN cord-312743-9e4yufo5 36 33 AB AB NNP cord-312743-9e4yufo5 36 34 individuals individual NNS cord-312743-9e4yufo5 36 35 are be VBP cord-312743-9e4yufo5 36 36 decorated decorate VBN cord-312743-9e4yufo5 36 37 by by IN cord-312743-9e4yufo5 36 38 both both CC cord-312743-9e4yufo5 36 39 A A NNP cord-312743-9e4yufo5 36 40 and and CC cord-312743-9e4yufo5 36 41 B b NN cord-312743-9e4yufo5 36 42 epitopes epitope NNS cord-312743-9e4yufo5 36 43 . . . cord-312743-9e4yufo5 37 1 Transmission transmission NN cord-312743-9e4yufo5 37 2 of of IN cord-312743-9e4yufo5 37 3 such such JJ cord-312743-9e4yufo5 37 4 viruses virus NNS cord-312743-9e4yufo5 37 5 will will MD cord-312743-9e4yufo5 37 6 be be VB cord-312743-9e4yufo5 37 7 decreased decrease VBN cord-312743-9e4yufo5 37 8 by by IN cord-312743-9e4yufo5 37 9 the the DT cord-312743-9e4yufo5 37 10 presence presence NN cord-312743-9e4yufo5 37 11 of of IN cord-312743-9e4yufo5 37 12 either either DT cord-312743-9e4yufo5 37 13 anti anti JJ cord-312743-9e4yufo5 37 14 - - JJ cord-312743-9e4yufo5 37 15 A a JJ cord-312743-9e4yufo5 37 16 and/or and/or CC cord-312743-9e4yufo5 37 17 anti anti NN cord-312743-9e4yufo5 37 18 - - NN cord-312743-9e4yufo5 37 19 B b NN cord-312743-9e4yufo5 37 20 of of IN cord-312743-9e4yufo5 37 21 the the DT cord-312743-9e4yufo5 37 22 recipient recipient NN cord-312743-9e4yufo5 37 23 ( ( -LRB- cord-312743-9e4yufo5 37 24 dashed dash VBN cord-312743-9e4yufo5 37 25 arrows arrow NNS cord-312743-9e4yufo5 37 26 ) ) -RRB- cord-312743-9e4yufo5 37 27 . . . cord-312743-9e4yufo5 38 1 Transmission transmission NN cord-312743-9e4yufo5 38 2 between between IN cord-312743-9e4yufo5 38 3 individuals individual NNS cord-312743-9e4yufo5 38 4 of of IN cord-312743-9e4yufo5 38 5 the the DT cord-312743-9e4yufo5 38 6 same same JJ cord-312743-9e4yufo5 38 7 subtype subtype NN cord-312743-9e4yufo5 38 8 will will MD cord-312743-9e4yufo5 38 9 always always RB cord-312743-9e4yufo5 38 10 be be VB cord-312743-9e4yufo5 38 11 maximal maximal JJ cord-312743-9e4yufo5 38 12 ( ( -LRB- cord-312743-9e4yufo5 38 13 circular circular JJ cord-312743-9e4yufo5 38 14 arrows arrow NNS cord-312743-9e4yufo5 38 15 ) ) -RRB- cord-312743-9e4yufo5 38 16 . . . cord-312743-9e4yufo5 39 1 In in IN cord-312743-9e4yufo5 39 2 the the DT cord-312743-9e4yufo5 39 3 presence presence NN cord-312743-9e4yufo5 39 4 of of IN cord-312743-9e4yufo5 39 5 high high JJ cord-312743-9e4yufo5 39 6 - - HYPH cord-312743-9e4yufo5 39 7 titered titered JJ cord-312743-9e4yufo5 39 8 anti anti NNP cord-312743-9e4yufo5 39 9 - - NNP cord-312743-9e4yufo5 39 10 A a JJ cord-312743-9e4yufo5 39 11 and and CC cord-312743-9e4yufo5 39 12 anti anti JJ cord-312743-9e4yufo5 39 13 - - JJ cord-312743-9e4yufo5 39 14 B b JJ cord-312743-9e4yufo5 39 15 antibodies antibody NNS cord-312743-9e4yufo5 39 16 , , , cord-312743-9e4yufo5 39 17 transmissions transmission NNS cord-312743-9e4yufo5 39 18 represented represent VBN cord-312743-9e4yufo5 39 19 by by IN cord-312743-9e4yufo5 39 20 dashed dash VBN cord-312743-9e4yufo5 39 21 arrows arrow NNS cord-312743-9e4yufo5 39 22 should should MD cord-312743-9e4yufo5 39 23 be be VB cord-312743-9e4yufo5 39 24 completely completely RB cord-312743-9e4yufo5 39 25 ablated ablate VBN cord-312743-9e4yufo5 39 26 . . . cord-312743-9e4yufo5 40 1 https://doi.org/10.1371/journal.ppat.1008556.g001 https://doi.org/10.1371/journal.ppat.1008556.g001 XX cord-312743-9e4yufo5 41 1 Evolution evolution NN cord-312743-9e4yufo5 41 2 of of IN cord-312743-9e4yufo5 41 3 carbohydrate carbohydrate NN cord-312743-9e4yufo5 41 4 antigens antigen NNS cord-312743-9e4yufo5 41 5 - - : cord-312743-9e4yufo5 41 6 microbial microbial JJ cord-312743-9e4yufo5 41 7 forces force NNS cord-312743-9e4yufo5 41 8 shaping shape VBG cord-312743-9e4yufo5 41 9 host host NN cord-312743-9e4yufo5 41 10 glycomes glycome NNS cord-312743-9e4yufo5 41 11 ? ? . cord-312743-9e4yufo5 42 1 Catastrophic catastrophic JJ cord-312743-9e4yufo5 42 2 - - HYPH cord-312743-9e4yufo5 42 3 selection selection NN cord-312743-9e4yufo5 42 4 " " '' cord-312743-9e4yufo5 42 5 interplay interplay NN cord-312743-9e4yufo5 42 6 between between IN cord-312743-9e4yufo5 42 7 enveloped envelop VBN cord-312743-9e4yufo5 42 8 virus virus NN cord-312743-9e4yufo5 42 9 epidemics epidemic NNS cord-312743-9e4yufo5 42 10 , , , cord-312743-9e4yufo5 42 11 mutated mutate VBN cord-312743-9e4yufo5 42 12 genes gene NNS cord-312743-9e4yufo5 42 13 of of IN cord-312743-9e4yufo5 42 14 enzymes enzyme NNS cord-312743-9e4yufo5 42 15 synthesizing synthesize VBG cord-312743-9e4yufo5 42 16 carbohydrate carbohydrate NN cord-312743-9e4yufo5 42 17 antigens antigen NNS cord-312743-9e4yufo5 42 18 , , , cord-312743-9e4yufo5 42 19 and and CC cord-312743-9e4yufo5 42 20 natural natural JJ cord-312743-9e4yufo5 42 21 anticarbohydrate anticarbohydrate JJ cord-312743-9e4yufo5 42 22 antibodies antibody NNS cord-312743-9e4yufo5 42 23 Serum Serum NNP cord-312743-9e4yufo5 42 24 Sickness sickness NN cord-312743-9e4yufo5 42 25 " " '' cord-312743-9e4yufo5 42 26 to to IN cord-312743-9e4yufo5 42 27 " " `` cord-312743-9e4yufo5 42 28 Xenosialitis Xenosialitis NNP cord-312743-9e4yufo5 42 29 " " '' cord-312743-9e4yufo5 42 30 : : : cord-312743-9e4yufo5 42 31 Past past NN cord-312743-9e4yufo5 42 32 , , , cord-312743-9e4yufo5 42 33 Present Present NNP cord-312743-9e4yufo5 42 34 , , , cord-312743-9e4yufo5 42 35 and and CC cord-312743-9e4yufo5 42 36 Future future JJ cord-312743-9e4yufo5 42 37 Significance significance NN cord-312743-9e4yufo5 42 38 of of IN cord-312743-9e4yufo5 42 39 the the DT cord-312743-9e4yufo5 42 40 Non non JJ cord-312743-9e4yufo5 42 41 - - JJ cord-312743-9e4yufo5 42 42 human human JJ cord-312743-9e4yufo5 42 43 Sialic Sialic NNP cord-312743-9e4yufo5 42 44 Acid Acid NNP cord-312743-9e4yufo5 42 45 Neu5Gc Neu5Gc NNP cord-312743-9e4yufo5 42 46 Absence absence NN cord-312743-9e4yufo5 42 47 of of IN cord-312743-9e4yufo5 42 48 Neu5Gc Neu5Gc NNP cord-312743-9e4yufo5 42 49 and and CC cord-312743-9e4yufo5 42 50 Presence Presence NNP cord-312743-9e4yufo5 42 51 of of IN cord-312743-9e4yufo5 42 52 Anti Anti NNP cord-312743-9e4yufo5 42 53 - - NNP cord-312743-9e4yufo5 42 54 Neu5Gc Neu5Gc NNP cord-312743-9e4yufo5 42 55 Antibodies Antibodies NNPS cord-312743-9e4yufo5 42 56 in in IN cord-312743-9e4yufo5 42 57 Humans- Humans- NNP cord-312743-9e4yufo5 43 1 An an DT cord-312743-9e4yufo5 43 2 Evolutionary Evolutionary NNP cord-312743-9e4yufo5 43 3 Perspective Perspective NNP cord-312743-9e4yufo5 43 4 ABO ABO NNP cord-312743-9e4yufo5 43 5 research research NN cord-312743-9e4yufo5 43 6 in in IN cord-312743-9e4yufo5 43 7 the the DT cord-312743-9e4yufo5 43 8 modern modern JJ cord-312743-9e4yufo5 43 9 era era NN cord-312743-9e4yufo5 43 10 of of IN cord-312743-9e4yufo5 43 11 genomics genomic NNS cord-312743-9e4yufo5 43 12 Blood Blood NNP cord-312743-9e4yufo5 43 13 group group NN cord-312743-9e4yufo5 43 14 isoantibody isoantibody NN cord-312743-9e4yufo5 43 15 stimulation stimulation NN cord-312743-9e4yufo5 43 16 in in IN cord-312743-9e4yufo5 43 17 man man NN cord-312743-9e4yufo5 43 18 by by IN cord-312743-9e4yufo5 43 19 feeding feed VBG cord-312743-9e4yufo5 43 20 blood blood NN cord-312743-9e4yufo5 43 21 - - HYPH cord-312743-9e4yufo5 43 22 group group NN cord-312743-9e4yufo5 43 23 active active JJ cord-312743-9e4yufo5 43 24 bacteria bacteria NNS cord-312743-9e4yufo5 43 25 Genetic genetic JJ cord-312743-9e4yufo5 43 26 regulation regulation NN cord-312743-9e4yufo5 43 27 of of IN cord-312743-9e4yufo5 43 28 the the DT cord-312743-9e4yufo5 43 29 expression expression NN cord-312743-9e4yufo5 43 30 of of IN cord-312743-9e4yufo5 43 31 ABH ABH NNP cord-312743-9e4yufo5 43 32 and and CC cord-312743-9e4yufo5 43 33 Lewis Lewis NNP cord-312743-9e4yufo5 43 34 antigens antigen NNS cord-312743-9e4yufo5 43 35 in in IN cord-312743-9e4yufo5 43 36 tissues tissue NNS cord-312743-9e4yufo5 43 37 Quantitation quantitation NN cord-312743-9e4yufo5 43 38 and and CC cord-312743-9e4yufo5 43 39 characterization characterization NN cord-312743-9e4yufo5 43 40 of of IN cord-312743-9e4yufo5 43 41 anti anti JJ cord-312743-9e4yufo5 43 42 - - JJ cord-312743-9e4yufo5 43 43 Galalpha1 Galalpha1 NNP cord-312743-9e4yufo5 43 44 - - HYPH cord-312743-9e4yufo5 43 45 3Gal 3gal CD cord-312743-9e4yufo5 43 46 antibodies antibody NNS cord-312743-9e4yufo5 43 47 in in IN cord-312743-9e4yufo5 43 48 sera sera NNP cord-312743-9e4yufo5 43 49 of of IN cord-312743-9e4yufo5 43 50 200 200 CD cord-312743-9e4yufo5 43 51 healthy healthy JJ cord-312743-9e4yufo5 43 52 persons person NNS cord-312743-9e4yufo5 44 1 Human human JJ cord-312743-9e4yufo5 44 2 B1 b1 NN cord-312743-9e4yufo5 44 3 Cells cell NNS cord-312743-9e4yufo5 44 4 are be VBP cord-312743-9e4yufo5 44 5 the the DT cord-312743-9e4yufo5 44 6 Main Main NNP cord-312743-9e4yufo5 44 7 Blood Blood NNP cord-312743-9e4yufo5 44 8 Group Group NNP cord-312743-9e4yufo5 44 9 A A NNP cord-312743-9e4yufo5 44 10 - - HYPH cord-312743-9e4yufo5 44 11 Specific specific JJ cord-312743-9e4yufo5 44 12 B b NN cord-312743-9e4yufo5 44 13 Cells cell NNS cord-312743-9e4yufo5 44 14 That that WDT cord-312743-9e4yufo5 44 15 Have have VBP cord-312743-9e4yufo5 44 16 a a DT cord-312743-9e4yufo5 44 17 Moderate moderate JJ cord-312743-9e4yufo5 44 18 Correlation correlation NN cord-312743-9e4yufo5 44 19 With with IN cord-312743-9e4yufo5 44 20 Anti Anti NNP cord-312743-9e4yufo5 44 21 - - NNP cord-312743-9e4yufo5 44 22 A A NNP cord-312743-9e4yufo5 44 23 Antibody Antibody NNP cord-312743-9e4yufo5 44 24 Titer Titer NNP cord-312743-9e4yufo5 44 25 Unexpected Unexpected NNP cord-312743-9e4yufo5 44 26 Receptor Receptor NNP cord-312743-9e4yufo5 44 27 Functional functional JJ cord-312743-9e4yufo5 44 28 Mimicry Mimicry NNP cord-312743-9e4yufo5 45 1 Elucidates elucidate VBZ cord-312743-9e4yufo5 45 2 Activation Activation NNP cord-312743-9e4yufo5 45 3 of of IN cord-312743-9e4yufo5 45 4 Coronavirus Coronavirus NNP cord-312743-9e4yufo5 45 5 Fusion Fusion NNP cord-312743-9e4yufo5 45 6 Functional functional JJ cord-312743-9e4yufo5 45 7 assessment assessment NN cord-312743-9e4yufo5 45 8 of of IN cord-312743-9e4yufo5 45 9 cell cell NN cord-312743-9e4yufo5 45 10 entry entry NN cord-312743-9e4yufo5 45 11 and and CC cord-312743-9e4yufo5 45 12 receptor receptor NN cord-312743-9e4yufo5 45 13 usage usage NN cord-312743-9e4yufo5 45 14 for for IN cord-312743-9e4yufo5 45 15 SARS SARS NNP cord-312743-9e4yufo5 45 16 - - HYPH cord-312743-9e4yufo5 45 17 CoV-2 CoV-2 NNP cord-312743-9e4yufo5 45 18 and and CC cord-312743-9e4yufo5 45 19 other other JJ cord-312743-9e4yufo5 45 20 lineage lineage NN cord-312743-9e4yufo5 45 21 B b NN cord-312743-9e4yufo5 45 22 betacoronaviruses betacoronaviruses NNP cord-312743-9e4yufo5 45 23 Tissue tissue NN cord-312743-9e4yufo5 45 24 distribution distribution NN cord-312743-9e4yufo5 45 25 of of IN cord-312743-9e4yufo5 45 26 ACE2 ACE2 NNP cord-312743-9e4yufo5 45 27 protein protein NN cord-312743-9e4yufo5 45 28 , , , cord-312743-9e4yufo5 45 29 the the DT cord-312743-9e4yufo5 45 30 functional functional JJ cord-312743-9e4yufo5 45 31 receptor receptor NN cord-312743-9e4yufo5 45 32 for for IN cord-312743-9e4yufo5 45 33 SARS SARS NNP cord-312743-9e4yufo5 45 34 coronavirus coronavirus NN cord-312743-9e4yufo5 45 35 . . . cord-312743-9e4yufo5 46 1 A a DT cord-312743-9e4yufo5 46 2 first first JJ cord-312743-9e4yufo5 46 3 step step NN cord-312743-9e4yufo5 46 4 in in IN cord-312743-9e4yufo5 46 5 understanding understand VBG cord-312743-9e4yufo5 46 6 SARS SARS NNP cord-312743-9e4yufo5 46 7 pathogenesis pathogenesis NN cord-312743-9e4yufo5 46 8 Single single JJ cord-312743-9e4yufo5 46 9 - - HYPH cord-312743-9e4yufo5 46 10 cell cell NN cord-312743-9e4yufo5 46 11 RNA rna NN cord-312743-9e4yufo5 46 12 expression expression NN cord-312743-9e4yufo5 46 13 profiling profiling NN cord-312743-9e4yufo5 46 14 of of IN cord-312743-9e4yufo5 46 15 ACE2 ACE2 NNP cord-312743-9e4yufo5 46 16 , , , cord-312743-9e4yufo5 46 17 the the DT cord-312743-9e4yufo5 46 18 putative putative JJ cord-312743-9e4yufo5 46 19 receptor receptor NN cord-312743-9e4yufo5 46 20 of of IN cord-312743-9e4yufo5 46 21 Wuhan Wuhan NNP cord-312743-9e4yufo5 46 22 2019-nCov 2019-ncov CD cord-312743-9e4yufo5 46 23 Inhibition Inhibition NNP cord-312743-9e4yufo5 46 24 of of IN cord-312743-9e4yufo5 46 25 the the DT cord-312743-9e4yufo5 46 26 interaction interaction NN cord-312743-9e4yufo5 46 27 beteen beteen IN cord-312743-9e4yufo5 46 28 the the DT cord-312743-9e4yufo5 46 29 SARS SARS NNP cord-312743-9e4yufo5 46 30 - - HYPH cord-312743-9e4yufo5 46 31 CoV CoV NNP cord-312743-9e4yufo5 46 32 spike spike NN cord-312743-9e4yufo5 46 33 protein protein NN cord-312743-9e4yufo5 46 34 and and CC cord-312743-9e4yufo5 46 35 its -PRON- PRP$ cord-312743-9e4yufo5 46 36 cellular cellular JJ cord-312743-9e4yufo5 46 37 receptor receptor NN cord-312743-9e4yufo5 46 38 by by IN cord-312743-9e4yufo5 46 39 anti anti JJ cord-312743-9e4yufo5 46 40 - - JJ cord-312743-9e4yufo5 46 41 histo histo JJ cord-312743-9e4yufo5 46 42 - - HYPH cord-312743-9e4yufo5 46 43 blood blood NN cord-312743-9e4yufo5 46 44 group group NN cord-312743-9e4yufo5 46 45 antibodies antibody NNS cord-312743-9e4yufo5 46 46 ABO ABO NNP cord-312743-9e4yufo5 46 47 blood blood NN cord-312743-9e4yufo5 46 48 group group NN cord-312743-9e4yufo5 46 49 and and CC cord-312743-9e4yufo5 46 50 susceptibility susceptibility NN cord-312743-9e4yufo5 46 51 to to IN cord-312743-9e4yufo5 46 52 severe severe JJ cord-312743-9e4yufo5 46 53 acute acute JJ cord-312743-9e4yufo5 46 54 respiratory respiratory JJ cord-312743-9e4yufo5 46 55 syndrome syndrome NN cord-312743-9e4yufo5 46 56 Relationship relationship NN cord-312743-9e4yufo5 46 57 between between IN cord-312743-9e4yufo5 46 58 the the DT cord-312743-9e4yufo5 46 59 ABO ABO NNP cord-312743-9e4yufo5 46 60 Blood Blood NNP cord-312743-9e4yufo5 46 61 Group Group NNP cord-312743-9e4yufo5 46 62 and and CC cord-312743-9e4yufo5 46 63 the the DT cord-312743-9e4yufo5 46 64 COVID-19 COVID-19 NNP cord-312743-9e4yufo5 46 65 Susceptib Susceptib NNP cord-312743-9e4yufo5 46 66 Phylogenetic Phylogenetic NNP cord-312743-9e4yufo5 46 67 Distribution Distribution NNP cord-312743-9e4yufo5 46 68 of of IN cord-312743-9e4yufo5 46 69 CMP CMP NNP cord-312743-9e4yufo5 46 70 - - HYPH cord-312743-9e4yufo5 46 71 Neu5Ac Neu5Ac NNP cord-312743-9e4yufo5 46 72 Hydroxylase Hydroxylase NNP cord-312743-9e4yufo5 46 73 ( ( -LRB- cord-312743-9e4yufo5 46 74 CMAH CMAH NNP cord-312743-9e4yufo5 46 75 ) ) -RRB- cord-312743-9e4yufo5 46 76 , , , cord-312743-9e4yufo5 46 77 the the DT cord-312743-9e4yufo5 46 78 Enzyme Enzyme NNP cord-312743-9e4yufo5 46 79 Synthetizing Synthetizing NNP cord-312743-9e4yufo5 46 80 the the DT cord-312743-9e4yufo5 46 81 Proinflammatory Proinflammatory NNP cord-312743-9e4yufo5 46 82 Human Human NNP cord-312743-9e4yufo5 46 83 Xenoantigen Xenoantigen NNP cord-312743-9e4yufo5 46 84 Neu5Gc Neu5Gc NNP cord-312743-9e4yufo5 46 85 Cryo Cryo NNP cord-312743-9e4yufo5 46 86 - - HYPH cord-312743-9e4yufo5 46 87 EM EM NNP cord-312743-9e4yufo5 46 88 structure structure NN cord-312743-9e4yufo5 46 89 of of IN cord-312743-9e4yufo5 46 90 the the DT cord-312743-9e4yufo5 46 91 2019-nCoV 2019-ncov CD cord-312743-9e4yufo5 46 92 spike spike NN cord-312743-9e4yufo5 46 93 in in IN cord-312743-9e4yufo5 46 94 the the DT cord-312743-9e4yufo5 46 95 prefusion prefusion NN cord-312743-9e4yufo5 46 96 conformation conformation NN cord-312743-9e4yufo5 46 97 Induction Induction NNP cord-312743-9e4yufo5 46 98 of of IN cord-312743-9e4yufo5 46 99 cytolytic cytolytic JJ cord-312743-9e4yufo5 46 100 anti anti JJ cord-312743-9e4yufo5 46 101 - - JJ cord-312743-9e4yufo5 46 102 gal gal JJ cord-312743-9e4yufo5 46 103 antibodies antibody NNS cord-312743-9e4yufo5 46 104 in in IN cord-312743-9e4yufo5 46 105 α-1,3-galactosyltransferase α-1,3-galactosyltransferase NN cord-312743-9e4yufo5 46 106 gene gene NN cord-312743-9e4yufo5 46 107 knockout knockout NN cord-312743-9e4yufo5 46 108 mice mouse NNS cord-312743-9e4yufo5 46 109 by by IN cord-312743-9e4yufo5 46 110 oral oral JJ cord-312743-9e4yufo5 46 111 inoculation inoculation NN cord-312743-9e4yufo5 46 112 with with IN cord-312743-9e4yufo5 46 113 Escherichia Escherichia NNP cord-312743-9e4yufo5 46 114 coli coli NNS cord-312743-9e4yufo5 46 115 O86 O86 NNP cord-312743-9e4yufo5 46 116 : : : cord-312743-9e4yufo5 46 117 B7 b7 NN cord-312743-9e4yufo5 46 118 bacteria bacteria NNS cord-312743-9e4yufo5 46 119 Development Development NNP cord-312743-9e4yufo5 46 120 of of IN cord-312743-9e4yufo5 46 121 a a DT cord-312743-9e4yufo5 46 122 - - HYPH cord-312743-9e4yufo5 46 123 Gal Gal NNP cord-312743-9e4yufo5 46 124 - - HYPH cord-312743-9e4yufo5 46 125 Antibody antibody NN cord-312743-9e4yufo5 46 126 Conjugates Conjugates NNPS cord-312743-9e4yufo5 46 127 to to TO cord-312743-9e4yufo5 46 128 Increase increase VB cord-312743-9e4yufo5 46 129 Immune immune JJ cord-312743-9e4yufo5 46 130 Response response NN cord-312743-9e4yufo5 46 131 by by IN cord-312743-9e4yufo5 46 132 Recruiting recruit VBG cord-312743-9e4yufo5 46 133 Natural Natural NNP cord-312743-9e4yufo5 46 134 Antibodies Antibodies NNPS cord-312743-9e4yufo5 47 1 A a DT cord-312743-9e4yufo5 47 2 red red JJ cord-312743-9e4yufo5 47 3 meat meat NN cord-312743-9e4yufo5 47 4 - - HYPH cord-312743-9e4yufo5 47 5 derived derive VBN cord-312743-9e4yufo5 47 6 glycan glycan NN cord-312743-9e4yufo5 47 7 promotes promote VBZ cord-312743-9e4yufo5 47 8 inflammation inflammation NN cord-312743-9e4yufo5 47 9 and and CC cord-312743-9e4yufo5 47 10 cancer cancer NN cord-312743-9e4yufo5 47 11 progression progression NN cord-312743-9e4yufo5 48 1 The the DT cord-312743-9e4yufo5 48 2 authors author NNS cord-312743-9e4yufo5 48 3 are be VBP cord-312743-9e4yufo5 48 4 grateful grateful JJ cord-312743-9e4yufo5 48 5 to to IN cord-312743-9e4yufo5 48 6 Hanane Hanane NNP cord-312743-9e4yufo5 48 7 El El NNP cord-312743-9e4yufo5 48 8 Kenz Kenz NNP cord-312743-9e4yufo5 49 1 ( ( -LRB- cord-312743-9e4yufo5 49 2 Brugmann Brugmann NNP cord-312743-9e4yufo5 49 3 University University NNP cord-312743-9e4yufo5 49 4 Hospital Hospital NNP cord-312743-9e4yufo5 49 5 , , , cord-312743-9e4yufo5 49 6 Brussels Brussels NNP cord-312743-9e4yufo5 49 7 , , , cord-312743-9e4yufo5 49 8 Belgium Belgium NNP cord-312743-9e4yufo5 49 9 ) ) -RRB- cord-312743-9e4yufo5 49 10 and and CC cord-312743-9e4yufo5 49 11 France France NNP cord-312743-9e4yufo5 49 12 Pirenne Pirenne NNP cord-312743-9e4yufo5 49 13 ( ( -LRB- cord-312743-9e4yufo5 49 14 Henri Henri NNP cord-312743-9e4yufo5 49 15 Mondor Mondor NNP cord-312743-9e4yufo5 49 16 University University NNP cord-312743-9e4yufo5 49 17 Hospital Hospital NNP cord-312743-9e4yufo5 49 18 , , , cord-312743-9e4yufo5 49 19 Créteil Créteil NNP cord-312743-9e4yufo5 49 20 , , , cord-312743-9e4yufo5 49 21 France France NNP cord-312743-9e4yufo5 49 22 ) ) -RRB- cord-312743-9e4yufo5 49 23 for for IN cord-312743-9e4yufo5 49 24 fruitful fruitful JJ cord-312743-9e4yufo5 49 25 discussions discussion NNS cord-312743-9e4yufo5 49 26 and and CC cord-312743-9e4yufo5 49 27 helpful helpful JJ cord-312743-9e4yufo5 49 28 remarks remark NNS cord-312743-9e4yufo5 49 29 . . .