id	sid	tid	token	lemma	pos
cord-295559-yc8q62z8	1	1	key	key	JJ
cord-295559-yc8q62z8	1	2	:	:	:
cord-295559-yc8q62z8	1	3	cord-295559-yc8q62z8	cord-295559-yc8q62z8	NN
cord-295559-yc8q62z8	2	1	authors	author	NNS
cord-295559-yc8q62z8	2	2	:	:	:
cord-295559-yc8q62z8	2	3	Qian	Qian	NNP
cord-295559-yc8q62z8	2	4	,	,	,
cord-295559-yc8q62z8	2	5	Zhaohui	Zhaohui	NNP
cord-295559-yc8q62z8	2	6	;	;	:
cord-295559-yc8q62z8	2	7	Dominguez	Dominguez	NNP
cord-295559-yc8q62z8	2	8	,	,	,
cord-295559-yc8q62z8	2	9	Samuel	Samuel	NNP
cord-295559-yc8q62z8	2	10	R.	R.	NNP
cord-295559-yc8q62z8	2	11	;	;	:
cord-295559-yc8q62z8	2	12	Holmes	Holmes	NNP
cord-295559-yc8q62z8	2	13	,	,	,
cord-295559-yc8q62z8	2	14	Kathryn	Kathryn	NNP
cord-295559-yc8q62z8	2	15	V.	V.	NNP
cord-295559-yc8q62z8	2	16	title	title	NN
cord-295559-yc8q62z8	2	17	:	:	:
cord-295559-yc8q62z8	2	18	Role	role	NN
cord-295559-yc8q62z8	2	19	of	of	IN
cord-295559-yc8q62z8	2	20	the	the	DT
cord-295559-yc8q62z8	2	21	Spike	Spike	NNP
cord-295559-yc8q62z8	2	22	Glycoprotein	Glycoprotein	NNP
cord-295559-yc8q62z8	2	23	of	of	IN
cord-295559-yc8q62z8	2	24	Human	Human	NNP
cord-295559-yc8q62z8	2	25	Middle	Middle	NNP
cord-295559-yc8q62z8	2	26	East	East	NNP
cord-295559-yc8q62z8	2	27	Respiratory	Respiratory	NNP
cord-295559-yc8q62z8	2	28	Syndrome	Syndrome	NNP
cord-295559-yc8q62z8	2	29	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	2	30	(	(	-LRB-
cord-295559-yc8q62z8	2	31	MERS	MERS	NNP
cord-295559-yc8q62z8	2	32	-	-	HYPH
cord-295559-yc8q62z8	2	33	CoV	CoV	NNP
cord-295559-yc8q62z8	2	34	)	)	-RRB-
cord-295559-yc8q62z8	2	35	in	in	IN
cord-295559-yc8q62z8	2	36	Virus	Virus	NNP
cord-295559-yc8q62z8	2	37	Entry	Entry	NNP
cord-295559-yc8q62z8	2	38	and	and	CC
cord-295559-yc8q62z8	2	39	Syncytia	Syncytia	NNP
cord-295559-yc8q62z8	2	40	Formation	Formation	NNP
cord-295559-yc8q62z8	2	41	date	date	NN
cord-295559-yc8q62z8	2	42	:	:	:
cord-295559-yc8q62z8	2	43	2013	2013	CD
cord-295559-yc8q62z8	2	44	-	-	SYM
cord-295559-yc8q62z8	2	45	10	10	CD
cord-295559-yc8q62z8	2	46	-	-	HYPH
cord-295559-yc8q62z8	2	47	03	03	CD
cord-295559-yc8q62z8	2	48	journal	journal	NN
cord-295559-yc8q62z8	2	49	:	:	:
cord-295559-yc8q62z8	3	1	PLoS	PLoS	NNP
cord-295559-yc8q62z8	3	2	One	one	CD
cord-295559-yc8q62z8	3	3	DOI	DOI	NNP
cord-295559-yc8q62z8	3	4	:	:	:
cord-295559-yc8q62z8	3	5	10.1371	10.1371	CD
cord-295559-yc8q62z8	3	6	/	/	SYM
cord-295559-yc8q62z8	3	7	journal.pone.0076469	journal.pone.0076469	VBD
cord-295559-yc8q62z8	3	8	sha	sha	NNP
cord-295559-yc8q62z8	3	9	:	:	:
cord-295559-yc8q62z8	3	10	5c533a06c3dc5afefab5dd138ec4de394b537261	5c533a06c3dc5afefab5dd138ec4de394b537261	CD
cord-295559-yc8q62z8	3	11	doc_id	doc_id	CD
cord-295559-yc8q62z8	3	12	:	:	:
cord-295559-yc8q62z8	3	13	295559	295559	CD
cord-295559-yc8q62z8	3	14	cord_uid	cord_uid	NNS
cord-295559-yc8q62z8	3	15	:	:	:
cord-295559-yc8q62z8	4	1	yc8q62z8	yc8q62z8	NNP
cord-295559-yc8q62z8	4	2	Little	little	JJ
cord-295559-yc8q62z8	4	3	is	be	VBZ
cord-295559-yc8q62z8	4	4	known	know	VBN
cord-295559-yc8q62z8	4	5	about	about	IN
cord-295559-yc8q62z8	4	6	the	the	DT
cord-295559-yc8q62z8	4	7	biology	biology	NN
cord-295559-yc8q62z8	4	8	of	of	IN
cord-295559-yc8q62z8	4	9	the	the	DT
cord-295559-yc8q62z8	4	10	emerging	emerge	VBG
cord-295559-yc8q62z8	4	11	human	human	JJ
cord-295559-yc8q62z8	4	12	group	group	NN
cord-295559-yc8q62z8	4	13	c	c	NNP
cord-295559-yc8q62z8	4	14	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	4	15	,	,	,
cord-295559-yc8q62z8	4	16	Middle	Middle	NNP
cord-295559-yc8q62z8	4	17	East	East	NNP
cord-295559-yc8q62z8	4	18	Respiratory	Respiratory	NNP
cord-295559-yc8q62z8	4	19	Syndrome	Syndrome	NNP
cord-295559-yc8q62z8	4	20	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	4	21	(	(	-LRB-
cord-295559-yc8q62z8	4	22	MERS	MERS	NNP
cord-295559-yc8q62z8	4	23	-	-	HYPH
cord-295559-yc8q62z8	4	24	CoV	CoV	NNP
cord-295559-yc8q62z8	4	25	)	)	-RRB-
cord-295559-yc8q62z8	4	26	.	.	.
cord-295559-yc8q62z8	5	1	Because	because	IN
cord-295559-yc8q62z8	5	2	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	5	3	spike	spike	NN
cord-295559-yc8q62z8	5	4	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	5	5	(	(	-LRB-
cord-295559-yc8q62z8	5	6	S	S	NNP
cord-295559-yc8q62z8	5	7	)	)	-RRB-
cord-295559-yc8q62z8	5	8	mediate	mediate	VB
cord-295559-yc8q62z8	5	9	virus	virus	NN
cord-295559-yc8q62z8	5	10	entry	entry	NN
cord-295559-yc8q62z8	5	11	,	,	,
cord-295559-yc8q62z8	5	12	affect	affect	VBP
cord-295559-yc8q62z8	5	13	viral	viral	JJ
cord-295559-yc8q62z8	5	14	host	host	NN
cord-295559-yc8q62z8	5	15	range	range	NN
cord-295559-yc8q62z8	5	16	,	,	,
cord-295559-yc8q62z8	5	17	and	and	CC
cord-295559-yc8q62z8	5	18	elicit	elicit	VB
cord-295559-yc8q62z8	5	19	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	5	20	antibodies	antibody	NNS
cord-295559-yc8q62z8	5	21	,	,	,
cord-295559-yc8q62z8	5	22	analyzing	analyze	VBG
cord-295559-yc8q62z8	5	23	the	the	DT
cord-295559-yc8q62z8	5	24	functions	function	NNS
cord-295559-yc8q62z8	5	25	of	of	IN
cord-295559-yc8q62z8	5	26	MERS	MERS	NNP
cord-295559-yc8q62z8	5	27	-	-	HYPH
cord-295559-yc8q62z8	5	28	CoV	CoV	NNP
cord-295559-yc8q62z8	5	29	S	S	NNP
cord-295559-yc8q62z8	5	30	protein	protein	NN
cord-295559-yc8q62z8	5	31	is	be	VBZ
cord-295559-yc8q62z8	5	32	a	a	DT
cord-295559-yc8q62z8	5	33	high	high	JJ
cord-295559-yc8q62z8	5	34	research	research	NN
cord-295559-yc8q62z8	5	35	priority	priority	NN
cord-295559-yc8q62z8	5	36	.	.	.
cord-295559-yc8q62z8	6	1	MERS	MERS	NNP
cord-295559-yc8q62z8	6	2	-	-	HYPH
cord-295559-yc8q62z8	6	3	CoV	CoV	NNP
cord-295559-yc8q62z8	6	4	S	S	NNP
cord-295559-yc8q62z8	6	5	on	on	IN
cord-295559-yc8q62z8	6	6	lentivirus	lentivirus	NN
cord-295559-yc8q62z8	6	7	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	6	8	mediated	mediate	VBN
cord-295559-yc8q62z8	6	9	entry	entry	NN
cord-295559-yc8q62z8	6	10	into	into	IN
cord-295559-yc8q62z8	6	11	a	a	DT
cord-295559-yc8q62z8	6	12	variety	variety	NN
cord-295559-yc8q62z8	6	13	of	of	IN
cord-295559-yc8q62z8	6	14	cell	cell	NN
cord-295559-yc8q62z8	6	15	types	type	NNS
cord-295559-yc8q62z8	6	16	including	include	VBG
cord-295559-yc8q62z8	6	17	embryo	embryo	NN
cord-295559-yc8q62z8	6	18	cells	cell	NNS
cord-295559-yc8q62z8	6	19	from	from	IN
cord-295559-yc8q62z8	6	20	New	New	NNP
cord-295559-yc8q62z8	6	21	World	World	NNP
cord-295559-yc8q62z8	6	22	Eptesicus	Eptesicus	NNP
cord-295559-yc8q62z8	6	23	fuscus	fuscus	NN
cord-295559-yc8q62z8	6	24	bats	bat	NNS
cord-295559-yc8q62z8	6	25	.	.	.
cord-295559-yc8q62z8	7	1	Surprisingly	surprisingly	RB
cord-295559-yc8q62z8	7	2	,	,	,
cord-295559-yc8q62z8	7	3	a	a	DT
cord-295559-yc8q62z8	7	4	polyclonal	polyclonal	JJ
cord-295559-yc8q62z8	7	5	antibody	antibody	NN
cord-295559-yc8q62z8	7	6	to	to	IN
cord-295559-yc8q62z8	7	7	the	the	DT
cord-295559-yc8q62z8	7	8	S	S	NNP
cord-295559-yc8q62z8	7	9	protein	protein	NN
cord-295559-yc8q62z8	7	10	of	of	IN
cord-295559-yc8q62z8	7	11	MHV	MHV	NNP
cord-295559-yc8q62z8	7	12	,	,	,
cord-295559-yc8q62z8	7	13	a	a	DT
cord-295559-yc8q62z8	7	14	group	group	NN
cord-295559-yc8q62z8	7	15	a	a	DT
cord-295559-yc8q62z8	7	16	murine	murine	JJ
cord-295559-yc8q62z8	7	17	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	7	18	,	,	,
cord-295559-yc8q62z8	7	19	cross	cross	NN
cord-295559-yc8q62z8	7	20	-	-	VBN
cord-295559-yc8q62z8	7	21	reacted	react	VBN
cord-295559-yc8q62z8	7	22	in	in	IN
cord-295559-yc8q62z8	7	23	immunoblots	immunoblot	NNS
cord-295559-yc8q62z8	7	24	with	with	IN
cord-295559-yc8q62z8	7	25	the	the	DT
cord-295559-yc8q62z8	7	26	S2	S2	NNP
cord-295559-yc8q62z8	7	27	domain	domain	NN
cord-295559-yc8q62z8	7	28	of	of	IN
cord-295559-yc8q62z8	7	29	group	group	NN
cord-295559-yc8q62z8	7	30	c	c	NN
cord-295559-yc8q62z8	7	31	MERS	MERS	NNP
cord-295559-yc8q62z8	7	32	-	-	HYPH
cord-295559-yc8q62z8	7	33	CoV	CoV	NNP
cord-295559-yc8q62z8	7	34	spike	spike	NN
cord-295559-yc8q62z8	7	35	protein	protein	NN
cord-295559-yc8q62z8	7	36	.	.	.
cord-295559-yc8q62z8	8	1	MERS	MERS	NNP
cord-295559-yc8q62z8	8	2	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	8	3	released	release	VBN
cord-295559-yc8q62z8	8	4	from	from	IN
cord-295559-yc8q62z8	8	5	293	293	CD
cord-295559-yc8q62z8	8	6	T	T	NNP
cord-295559-yc8q62z8	8	7	cells	cell	NNS
cord-295559-yc8q62z8	8	8	contained	contain	VBD
cord-295559-yc8q62z8	8	9	only	only	RB
cord-295559-yc8q62z8	8	10	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	8	11	S	S	NNP
cord-295559-yc8q62z8	8	12	,	,	,
cord-295559-yc8q62z8	8	13	and	and	CC
cord-295559-yc8q62z8	8	14	pseudovirus	pseudovirus	NNP
cord-295559-yc8q62z8	8	15	entry	entry	NN
cord-295559-yc8q62z8	8	16	was	be	VBD
cord-295559-yc8q62z8	8	17	blocked	block	VBN
cord-295559-yc8q62z8	8	18	by	by	IN
cord-295559-yc8q62z8	8	19	lysosomotropic	lysosomotropic	JJ
cord-295559-yc8q62z8	8	20	reagents	reagent	NNS
cord-295559-yc8q62z8	8	21	NH(4)Cl	nh(4)cl	CD
cord-295559-yc8q62z8	8	22	and	and	CC
cord-295559-yc8q62z8	8	23	bafilomycin	bafilomycin	NNS
cord-295559-yc8q62z8	8	24	and	and	CC
cord-295559-yc8q62z8	8	25	inhibitors	inhibitor	NNS
cord-295559-yc8q62z8	8	26	of	of	IN
cord-295559-yc8q62z8	8	27	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	8	28	L.	L.	NNP
cord-295559-yc8q62z8	9	1	However	however	RB
cord-295559-yc8q62z8	9	2	,	,	,
cord-295559-yc8q62z8	9	3	when	when	WRB
cord-295559-yc8q62z8	9	4	MERS	MERS	NNP
cord-295559-yc8q62z8	9	5	pseudovirions	pseudovirion	VBZ
cord-295559-yc8q62z8	9	6	with	with	IN
cord-295559-yc8q62z8	9	7	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	9	8	S	S	NNP
cord-295559-yc8q62z8	9	9	protein	protein	NN
cord-295559-yc8q62z8	9	10	were	be	VBD
cord-295559-yc8q62z8	9	11	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	9	12	at	at	IN
cord-295559-yc8q62z8	9	13	4	4	CD
cord-295559-yc8q62z8	9	14	°	°	NN
cord-295559-yc8q62z8	9	15	C	c	NN
cord-295559-yc8q62z8	9	16	to	to	IN
cord-295559-yc8q62z8	9	17	Vero	Vero	NNP
cord-295559-yc8q62z8	9	18	E6	E6	NNP
cord-295559-yc8q62z8	9	19	cells	cell	NNS
cord-295559-yc8q62z8	9	20	,	,	,
cord-295559-yc8q62z8	9	21	brief	brief	JJ
cord-295559-yc8q62z8	9	22	trypsin	trypsin	NN
cord-295559-yc8q62z8	9	23	treatment	treatment	NN
cord-295559-yc8q62z8	9	24	at	at	IN
cord-295559-yc8q62z8	9	25	neutral	neutral	JJ
cord-295559-yc8q62z8	9	26	pH	pH	NNP
cord-295559-yc8q62z8	9	27	triggered	trigger	VBN
cord-295559-yc8q62z8	9	28	virus	virus	NN
cord-295559-yc8q62z8	9	29	entry	entry	NN
cord-295559-yc8q62z8	9	30	at	at	IN
cord-295559-yc8q62z8	9	31	the	the	DT
cord-295559-yc8q62z8	9	32	plasma	plasma	NN
cord-295559-yc8q62z8	9	33	membrane	membrane	NN
cord-295559-yc8q62z8	9	34	and	and	CC
cord-295559-yc8q62z8	9	35	syncytia	syncytia	NN
cord-295559-yc8q62z8	9	36	formation	formation	NN
cord-295559-yc8q62z8	9	37	.	.	.
cord-295559-yc8q62z8	10	1	When	when	WRB
cord-295559-yc8q62z8	10	2	293	293	CD
cord-295559-yc8q62z8	10	3	T	t	NN
cord-295559-yc8q62z8	10	4	cells	cell	NNS
cord-295559-yc8q62z8	10	5	producing	produce	VBG
cord-295559-yc8q62z8	10	6	MERS	MERS	NNP
cord-295559-yc8q62z8	10	7	pseudotypes	pseudotype	NNS
cord-295559-yc8q62z8	10	8	co	co	VBD
cord-295559-yc8q62z8	10	9	-	-	VBD
cord-295559-yc8q62z8	10	10	expressed	express	VBN
cord-295559-yc8q62z8	10	11	serine	serine	NN
cord-295559-yc8q62z8	10	12	proteases	protease	NNS
cord-295559-yc8q62z8	10	13	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	10	14	or	or	CC
cord-295559-yc8q62z8	10	15	-4	-4	CD
cord-295559-yc8q62z8	10	16	,	,	,
cord-295559-yc8q62z8	10	17	large	large	JJ
cord-295559-yc8q62z8	10	18	syncytia	syncytia	NN
cord-295559-yc8q62z8	10	19	formed	form	VBN
cord-295559-yc8q62z8	10	20	at	at	IN
cord-295559-yc8q62z8	10	21	neutral	neutral	JJ
cord-295559-yc8q62z8	10	22	pH	pH	NNP
cord-295559-yc8q62z8	10	23	,	,	,
cord-295559-yc8q62z8	10	24	and	and	CC
cord-295559-yc8q62z8	10	25	the	the	DT
cord-295559-yc8q62z8	10	26	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	10	27	produced	produce	VBN
cord-295559-yc8q62z8	10	28	were	be	VBD
cord-295559-yc8q62z8	10	29	non	non	JJ
cord-295559-yc8q62z8	10	30	-	-	JJ
cord-295559-yc8q62z8	10	31	infectious	infectious	JJ
cord-295559-yc8q62z8	10	32	and	and	CC
cord-295559-yc8q62z8	10	33	deficient	deficient	JJ
cord-295559-yc8q62z8	10	34	in	in	IN
cord-295559-yc8q62z8	10	35	S	s	NN
cord-295559-yc8q62z8	10	36	protein	protein	NN
cord-295559-yc8q62z8	10	37	.	.	.
cord-295559-yc8q62z8	11	1	These	these	DT
cord-295559-yc8q62z8	11	2	experiments	experiment	NNS
cord-295559-yc8q62z8	11	3	show	show	VBP
cord-295559-yc8q62z8	11	4	that	that	IN
cord-295559-yc8q62z8	11	5	if	if	IN
cord-295559-yc8q62z8	11	6	S	S	NNP
cord-295559-yc8q62z8	11	7	protein	protein	NN
cord-295559-yc8q62z8	11	8	on	on	IN
cord-295559-yc8q62z8	11	9	MERS	MERS	NNP
cord-295559-yc8q62z8	11	10	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	11	11	is	be	VBZ
cord-295559-yc8q62z8	11	12	uncleaved	uncleave	VBN
cord-295559-yc8q62z8	11	13	,	,	,
cord-295559-yc8q62z8	11	14	then	then	RB
cord-295559-yc8q62z8	11	15	viruses	virus	NNS
cord-295559-yc8q62z8	11	16	enter	enter	VBP
cord-295559-yc8q62z8	11	17	by	by	IN
cord-295559-yc8q62z8	11	18	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	11	19	in	in	IN
cord-295559-yc8q62z8	11	20	a	a	DT
cord-295559-yc8q62z8	11	21	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	11	22	L	l	NN
cord-295559-yc8q62z8	11	23	-	-	HYPH
cord-295559-yc8q62z8	11	24	dependent	dependent	JJ
cord-295559-yc8q62z8	11	25	manner	manner	NN
cord-295559-yc8q62z8	11	26	,	,	,
cord-295559-yc8q62z8	11	27	but	but	CC
cord-295559-yc8q62z8	11	28	if	if	IN
cord-295559-yc8q62z8	11	29	MERS	MERS	NNP
cord-295559-yc8q62z8	11	30	-	-	HYPH
cord-295559-yc8q62z8	11	31	CoV	CoV	NNP
cord-295559-yc8q62z8	11	32	S	S	NNP
cord-295559-yc8q62z8	11	33	is	be	VBZ
cord-295559-yc8q62z8	11	34	cleaved	cleave	VBN
cord-295559-yc8q62z8	11	35	,	,	,
cord-295559-yc8q62z8	11	36	either	either	CC
cord-295559-yc8q62z8	11	37	during	during	IN
cord-295559-yc8q62z8	11	38	virus	virus	NN
cord-295559-yc8q62z8	11	39	maturation	maturation	NN
cord-295559-yc8q62z8	11	40	by	by	IN
cord-295559-yc8q62z8	11	41	serine	serine	NN
cord-295559-yc8q62z8	11	42	proteases	protease	NNS
cord-295559-yc8q62z8	11	43	or	or	CC
cord-295559-yc8q62z8	11	44	on	on	IN
cord-295559-yc8q62z8	11	45	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	11	46	by	by	IN
cord-295559-yc8q62z8	11	47	trypsin	trypsin	NN
cord-295559-yc8q62z8	11	48	in	in	IN
cord-295559-yc8q62z8	11	49	extracellular	extracellular	JJ
cord-295559-yc8q62z8	11	50	fluids	fluid	NNS
cord-295559-yc8q62z8	11	51	,	,	,
cord-295559-yc8q62z8	11	52	then	then	RB
cord-295559-yc8q62z8	11	53	viruses	virus	NNS
cord-295559-yc8q62z8	11	54	enter	enter	VBP
cord-295559-yc8q62z8	11	55	at	at	IN
cord-295559-yc8q62z8	11	56	the	the	DT
cord-295559-yc8q62z8	11	57	plasma	plasma	NN
cord-295559-yc8q62z8	11	58	membrane	membrane	NN
cord-295559-yc8q62z8	11	59	at	at	IN
cord-295559-yc8q62z8	11	60	neutral	neutral	JJ
cord-295559-yc8q62z8	11	61	pH	pH	NNP
cord-295559-yc8q62z8	11	62	and	and	CC
cord-295559-yc8q62z8	11	63	cause	cause	VB
cord-295559-yc8q62z8	11	64	massive	massive	JJ
cord-295559-yc8q62z8	11	65	syncytia	syncytia	NN
cord-295559-yc8q62z8	11	66	formation	formation	NN
cord-295559-yc8q62z8	11	67	even	even	RB
cord-295559-yc8q62z8	11	68	in	in	IN
cord-295559-yc8q62z8	11	69	cells	cell	NNS
cord-295559-yc8q62z8	11	70	that	that	WDT
cord-295559-yc8q62z8	11	71	express	express	VBP
cord-295559-yc8q62z8	11	72	little	little	JJ
cord-295559-yc8q62z8	11	73	or	or	CC
cord-295559-yc8q62z8	11	74	no	no	DT
cord-295559-yc8q62z8	11	75	MERS	MERS	NNP
cord-295559-yc8q62z8	11	76	-	-	HYPH
cord-295559-yc8q62z8	11	77	CoV	cov	NN
cord-295559-yc8q62z8	11	78	receptor	receptor	NN
cord-295559-yc8q62z8	11	79	.	.	.
cord-295559-yc8q62z8	12	1	Thus	thus	RB
cord-295559-yc8q62z8	12	2	,	,	,
cord-295559-yc8q62z8	12	3	whether	whether	IN
cord-295559-yc8q62z8	12	4	MERS	MERS	NNP
cord-295559-yc8q62z8	12	5	-	-	HYPH
cord-295559-yc8q62z8	12	6	CoV	CoV	NNP
cord-295559-yc8q62z8	12	7	enters	enter	VBZ
cord-295559-yc8q62z8	12	8	cells	cell	NNS
cord-295559-yc8q62z8	12	9	within	within	IN
cord-295559-yc8q62z8	12	10	endosomes	endosome	NNS
cord-295559-yc8q62z8	12	11	or	or	CC
cord-295559-yc8q62z8	12	12	at	at	IN
cord-295559-yc8q62z8	12	13	the	the	DT
cord-295559-yc8q62z8	12	14	plasma	plasma	NN
cord-295559-yc8q62z8	12	15	membrane	membrane	NN
cord-295559-yc8q62z8	12	16	depends	depend	VBZ
cord-295559-yc8q62z8	12	17	upon	upon	IN
cord-295559-yc8q62z8	12	18	the	the	DT
cord-295559-yc8q62z8	12	19	host	host	NN
cord-295559-yc8q62z8	12	20	cell	cell	NN
cord-295559-yc8q62z8	12	21	type	type	NN
cord-295559-yc8q62z8	12	22	and	and	CC
cord-295559-yc8q62z8	12	23	tissue	tissue	NN
cord-295559-yc8q62z8	12	24	,	,	,
cord-295559-yc8q62z8	12	25	and	and	CC
cord-295559-yc8q62z8	12	26	is	be	VBZ
cord-295559-yc8q62z8	12	27	determined	determine	VBN
cord-295559-yc8q62z8	12	28	by	by	IN
cord-295559-yc8q62z8	12	29	the	the	DT
cord-295559-yc8q62z8	12	30	location	location	NN
cord-295559-yc8q62z8	12	31	of	of	IN
cord-295559-yc8q62z8	12	32	host	host	NN
cord-295559-yc8q62z8	12	33	proteases	protease	NNS
cord-295559-yc8q62z8	12	34	that	that	WDT
cord-295559-yc8q62z8	12	35	cleave	cleave	VBP
cord-295559-yc8q62z8	12	36	the	the	DT
cord-295559-yc8q62z8	12	37	viral	viral	JJ
cord-295559-yc8q62z8	12	38	spike	spike	NN
cord-295559-yc8q62z8	12	39	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	12	40	and	and	CC
cord-295559-yc8q62z8	12	41	activate	activate	VB
cord-295559-yc8q62z8	12	42	membrane	membrane	NN
cord-295559-yc8q62z8	12	43	fusion	fusion	NN
cord-295559-yc8q62z8	12	44	.	.	.
cord-295559-yc8q62z8	13	1	Coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	13	2	cause	cause	VBP
cord-295559-yc8q62z8	14	1	respiratory	respiratory	JJ
cord-295559-yc8q62z8	14	2	,	,	,
cord-295559-yc8q62z8	14	3	enteric	enteric	JJ
cord-295559-yc8q62z8	14	4	,	,	,
cord-295559-yc8q62z8	14	5	renal	renal	JJ
cord-295559-yc8q62z8	14	6	and/or	and/or	CC
cord-295559-yc8q62z8	14	7	neurological	neurological	JJ
cord-295559-yc8q62z8	14	8	disease	disease	NN
cord-295559-yc8q62z8	14	9	in	in	IN
cord-295559-yc8q62z8	14	10	humans	human	NNS
cord-295559-yc8q62z8	14	11	,	,	,
cord-295559-yc8q62z8	14	12	many	many	JJ
cord-295559-yc8q62z8	14	13	other	other	JJ
cord-295559-yc8q62z8	14	14	mammals	mammal	NNS
cord-295559-yc8q62z8	14	15	and	and	CC
cord-295559-yc8q62z8	14	16	birds	bird	NNS
cord-295559-yc8q62z8	14	17	.	.	.
cord-295559-yc8q62z8	15	1	In	in	IN
cord-295559-yc8q62z8	15	2	2002	2002	CD
cord-295559-yc8q62z8	15	3	-	-	SYM
cord-295559-yc8q62z8	15	4	03	03	CD
cord-295559-yc8q62z8	15	5	a	a	DT
cord-295559-yc8q62z8	15	6	previously	previously	RB
cord-295559-yc8q62z8	15	7	unknown	unknown	JJ
cord-295559-yc8q62z8	15	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	15	9	emerged	emerge	VBD
cord-295559-yc8q62z8	15	10	from	from	IN
cord-295559-yc8q62z8	15	11	a	a	DT
cord-295559-yc8q62z8	15	12	wild	wild	JJ
cord-295559-yc8q62z8	15	13	animal	animal	NN
cord-295559-yc8q62z8	15	14	reservoir	reservoir	NN
cord-295559-yc8q62z8	15	15	to	to	TO
cord-295559-yc8q62z8	15	16	cause	cause	VB
cord-295559-yc8q62z8	15	17	the	the	DT
cord-295559-yc8q62z8	15	18	SARS	SARS	NNP
cord-295559-yc8q62z8	15	19	pandemic	pandemic	NN
cord-295559-yc8q62z8	15	20	,	,	,
cord-295559-yc8q62z8	15	21	with	with	IN
cord-295559-yc8q62z8	15	22	about	about	RB
cord-295559-yc8q62z8	15	23	8,000	8,000	CD
cord-295559-yc8q62z8	15	24	human	human	JJ
cord-295559-yc8q62z8	15	25	cases	case	NNS
cord-295559-yc8q62z8	15	26	and	and	CC
cord-295559-yc8q62z8	15	27	more	more	JJR
cord-295559-yc8q62z8	15	28	than	than	IN
cord-295559-yc8q62z8	15	29	770	770	CD
cord-295559-yc8q62z8	15	30	deaths	death	NNS
cord-295559-yc8q62z8	15	31	[	[	-LRB-
cord-295559-yc8q62z8	15	32	1	1	CD
cord-295559-yc8q62z8	15	33	,	,	,
cord-295559-yc8q62z8	15	34	2	2	CD
cord-295559-yc8q62z8	15	35	]	]	-RRB-
cord-295559-yc8q62z8	15	36	.	.	.
cord-295559-yc8q62z8	16	1	Previously	previously	RB
cord-295559-yc8q62z8	16	2	,	,	,
cord-295559-yc8q62z8	16	3	cross	cross	JJ
cord-295559-yc8q62z8	16	4	-	-	JJ
cord-295559-yc8q62z8	16	5	species	species	JJ
cord-295559-yc8q62z8	16	6	transmission	transmission	NN
cord-295559-yc8q62z8	16	7	from	from	IN
cord-295559-yc8q62z8	16	8	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	16	9	of	of	IN
cord-295559-yc8q62z8	16	10	bat	bat	NN
cord-295559-yc8q62z8	16	11	and	and	CC
cord-295559-yc8q62z8	16	12	bovine	bovine	JJ
cord-295559-yc8q62z8	16	13	origin	origin	NN
cord-295559-yc8q62z8	16	14	had	have	VBD
cord-295559-yc8q62z8	16	15	allowed	allow	VBN
cord-295559-yc8q62z8	16	16	human	human	JJ
cord-295559-yc8q62z8	16	17	respiratory	respiratory	JJ
cord-295559-yc8q62z8	16	18	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	17	1	OC43	OC43	NNP
cord-295559-yc8q62z8	17	2	,	,	,
cord-295559-yc8q62z8	17	3	NL63	NL63	NNP
cord-295559-yc8q62z8	17	4	and	and	CC
cord-295559-yc8q62z8	17	5	229E	229e	CD
cord-295559-yc8q62z8	17	6	to	to	TO
cord-295559-yc8q62z8	17	7	become	become	VB
cord-295559-yc8q62z8	17	8	established	establish	VBN
cord-295559-yc8q62z8	17	9	in	in	IN
cord-295559-yc8q62z8	17	10	the	the	DT
cord-295559-yc8q62z8	17	11	human	human	JJ
cord-295559-yc8q62z8	17	12	population	population	NN
cord-295559-yc8q62z8	17	13	worldwide	worldwide	RB
cord-295559-yc8q62z8	17	14	[	[	-LRB-
cord-295559-yc8q62z8	17	15	3	3	CD
cord-295559-yc8q62z8	17	16	]	]	-RRB-
cord-295559-yc8q62z8	17	17	[	[	-LRB-
cord-295559-yc8q62z8	17	18	4	4	CD
cord-295559-yc8q62z8	17	19	]	]	-RRB-
cord-295559-yc8q62z8	17	20	[	[	-LRB-
cord-295559-yc8q62z8	17	21	5	5	CD
cord-295559-yc8q62z8	17	22	]	]	-RRB-
cord-295559-yc8q62z8	17	23	[	[	-LRB-
cord-295559-yc8q62z8	17	24	6	6	CD
cord-295559-yc8q62z8	17	25	]	]	-RRB-
cord-295559-yc8q62z8	17	26	[	[	-LRB-
cord-295559-yc8q62z8	17	27	7	7	CD
cord-295559-yc8q62z8	17	28	]	]	-RRB-
cord-295559-yc8q62z8	18	1	[	[	-LRB-
cord-295559-yc8q62z8	18	2	8	8	CD
cord-295559-yc8q62z8	18	3	]	]	-RRB-
cord-295559-yc8q62z8	18	4	.	.	.
cord-295559-yc8q62z8	19	1	In	in	IN
cord-295559-yc8q62z8	19	2	the	the	DT
cord-295559-yc8q62z8	19	3	Arabian	Arabian	NNP
cord-295559-yc8q62z8	19	4	Peninsula	Peninsula	NNP
cord-295559-yc8q62z8	19	5	in	in	IN
cord-295559-yc8q62z8	19	6	2012	2012	CD
cord-295559-yc8q62z8	19	7	,	,	,
cord-295559-yc8q62z8	19	8	another	another	DT
cord-295559-yc8q62z8	19	9	novel	novel	JJ
cord-295559-yc8q62z8	19	10	human	human	NN
cord-295559-yc8q62z8	19	11	CoV	cov	NN
cord-295559-yc8q62z8	19	12	,	,	,
cord-295559-yc8q62z8	19	13	now	now	RB
cord-295559-yc8q62z8	19	14	called	call	VBN
cord-295559-yc8q62z8	19	15	Middle	Middle	NNP
cord-295559-yc8q62z8	19	16	East	East	NNP
cord-295559-yc8q62z8	19	17	Respiratory	Respiratory	NNP
cord-295559-yc8q62z8	19	18	Syndrome	Syndrome	NNP
cord-295559-yc8q62z8	19	19	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	19	20	(	(	-LRB-
cord-295559-yc8q62z8	19	21	MERS	MERS	NNP
cord-295559-yc8q62z8	19	22	-	-	HYPH
cord-295559-yc8q62z8	19	23	CoV	CoV	NNP
cord-295559-yc8q62z8	19	24	)	)	-RRB-
cord-295559-yc8q62z8	19	25	,	,	,
cord-295559-yc8q62z8	19	26	was	be	VBD
cord-295559-yc8q62z8	19	27	isolated	isolate	VBN
cord-295559-yc8q62z8	19	28	in	in	IN
cord-295559-yc8q62z8	19	29	Vero	Vero	NNP
cord-295559-yc8q62z8	19	30	E6	E6	NNP
cord-295559-yc8q62z8	19	31	cells	cell	NNS
cord-295559-yc8q62z8	19	32	from	from	IN
cord-295559-yc8q62z8	19	33	sputum	sputum	NN
cord-295559-yc8q62z8	19	34	from	from	IN
cord-295559-yc8q62z8	19	35	a	a	DT
cord-295559-yc8q62z8	19	36	fatal	fatal	JJ
cord-295559-yc8q62z8	19	37	case	case	NN
cord-295559-yc8q62z8	19	38	of	of	IN
cord-295559-yc8q62z8	19	39	severe	severe	JJ
cord-295559-yc8q62z8	19	40	respiratory	respiratory	JJ
cord-295559-yc8q62z8	19	41	disease	disease	NN
cord-295559-yc8q62z8	19	42	with	with	IN
cord-295559-yc8q62z8	19	43	kidney	kidney	NN
cord-295559-yc8q62z8	19	44	failure	failure	NN
cord-295559-yc8q62z8	19	45	.	.	.
cord-295559-yc8q62z8	20	1	Since	since	IN
cord-295559-yc8q62z8	20	2	then	then	RB
cord-295559-yc8q62z8	20	3	,	,	,
cord-295559-yc8q62z8	20	4	MERS	MERS	NNP
cord-295559-yc8q62z8	20	5	-	-	HYPH
cord-295559-yc8q62z8	20	6	CoV	CoV	NNP
cord-295559-yc8q62z8	20	7	RNA	RNA	NNP
cord-295559-yc8q62z8	20	8	has	have	VBZ
cord-295559-yc8q62z8	20	9	been	be	VBN
cord-295559-yc8q62z8	20	10	detected	detect	VBN
cord-295559-yc8q62z8	20	11	by	by	IN
cord-295559-yc8q62z8	20	12	RT	RT	NNP
cord-295559-yc8q62z8	20	13	-	-	HYPH
cord-295559-yc8q62z8	20	14	PCR	PCR	NNP
cord-295559-yc8q62z8	20	15	in	in	IN
cord-295559-yc8q62z8	20	16	over	over	IN
cord-295559-yc8q62z8	20	17	70	70	CD
cord-295559-yc8q62z8	20	18	patients	patient	NNS
cord-295559-yc8q62z8	20	19	with	with	IN
cord-295559-yc8q62z8	20	20	severe	severe	JJ
cord-295559-yc8q62z8	20	21	to	to	TO
cord-295559-yc8q62z8	20	22	moderate	moderate	JJ
cord-295559-yc8q62z8	20	23	respiratory	respiratory	JJ
cord-295559-yc8q62z8	20	24	disease	disease	NN
cord-295559-yc8q62z8	20	25	,	,	,
cord-295559-yc8q62z8	20	26	39	39	CD
cord-295559-yc8q62z8	20	27	of	of	IN
cord-295559-yc8q62z8	20	28	whom	whom	WP
cord-295559-yc8q62z8	20	29	have	have	VBP
cord-295559-yc8q62z8	20	30	died	die	VBN
cord-295559-yc8q62z8	20	31	[	[	-LRB-
cord-295559-yc8q62z8	20	32	9	9	CD
cord-295559-yc8q62z8	20	33	,	,	,
cord-295559-yc8q62z8	20	34	10	10	CD
cord-295559-yc8q62z8	20	35	]	]	-RRB-
cord-295559-yc8q62z8	20	36	.	.	.
cord-295559-yc8q62z8	21	1	Genome	genome	NN
cord-295559-yc8q62z8	21	2	sequence	sequence	NN
cord-295559-yc8q62z8	21	3	analysis	analysis	NN
cord-295559-yc8q62z8	21	4	showed	show	VBD
cord-295559-yc8q62z8	21	5	that	that	IN
cord-295559-yc8q62z8	21	6	MERS	MERS	NNP
cord-295559-yc8q62z8	21	7	-	-	HYPH
cord-295559-yc8q62z8	21	8	CoV	CoV	NNP
cord-295559-yc8q62z8	21	9	is	be	VBZ
cord-295559-yc8q62z8	21	10	a	a	DT
cord-295559-yc8q62z8	21	11	novel	novel	JJ
cord-295559-yc8q62z8	21	12	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	21	13	in	in	IN
cord-295559-yc8q62z8	21	14	genogroup	genogroup	NNP
cord-295559-yc8q62z8	21	15	c	c	NNP
cord-295559-yc8q62z8	21	16	,	,	,
cord-295559-yc8q62z8	21	17	closely	closely	RB
cord-295559-yc8q62z8	21	18	related	relate	VBN
cord-295559-yc8q62z8	21	19	to	to	IN
cord-295559-yc8q62z8	21	20	two	two	CD
cord-295559-yc8q62z8	21	21	prototype	prototype	NN
cord-295559-yc8q62z8	21	22	group	group	NN
cord-295559-yc8q62z8	21	23	c	c	NNP
cord-295559-yc8q62z8	21	24	betacoronaviruses	betacoronaviruse	NNS
cord-295559-yc8q62z8	21	25	of	of	IN
cord-295559-yc8q62z8	21	26	Asian	asian	JJ
cord-295559-yc8q62z8	21	27	bats	bat	NNS
cord-295559-yc8q62z8	21	28	,	,	,
cord-295559-yc8q62z8	21	29	BtCoV	BtCoV	NNP
cord-295559-yc8q62z8	21	30	-	-	HYPH
cord-295559-yc8q62z8	21	31	HKU4	HKU4	NNP
cord-295559-yc8q62z8	21	32	from	from	IN
cord-295559-yc8q62z8	21	33	a	a	DT
cord-295559-yc8q62z8	21	34	Tylonycteris	Tylonycteris	NNP
cord-295559-yc8q62z8	21	35	pachypus	pachypus	JJ
cord-295559-yc8q62z8	21	36	bat	bat	NN
cord-295559-yc8q62z8	21	37	and	and	CC
cord-295559-yc8q62z8	21	38	BtCoV	BtCoV	NNP
cord-295559-yc8q62z8	21	39	-	-	HYPH
cord-295559-yc8q62z8	21	40	HKU5	HKU5	NNP
cord-295559-yc8q62z8	21	41	from	from	IN
cord-295559-yc8q62z8	21	42	a	a	DT
cord-295559-yc8q62z8	21	43	Pipistrellus	Pipistrellus	NNP
cord-295559-yc8q62z8	21	44	abramus	abramus	NN
cord-295559-yc8q62z8	21	45	bat	bat	NN
cord-295559-yc8q62z8	21	46	[	[	-LRB-
cord-295559-yc8q62z8	21	47	11	11	CD
cord-295559-yc8q62z8	21	48	]	]	-RRB-
cord-295559-yc8q62z8	21	49	,	,	,
cord-295559-yc8q62z8	21	50	and	and	CC
cord-295559-yc8q62z8	21	51	to	to	IN
cord-295559-yc8q62z8	21	52	partial	partial	JJ
cord-295559-yc8q62z8	21	53	sequences	sequence	NNS
cord-295559-yc8q62z8	21	54	of	of	IN
cord-295559-yc8q62z8	21	55	a	a	DT
cord-295559-yc8q62z8	21	56	group	group	NN
cord-295559-yc8q62z8	21	57	c	c	NN
cord-295559-yc8q62z8	21	58	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	21	59	from	from	IN
cord-295559-yc8q62z8	21	60	a	a	DT
cord-295559-yc8q62z8	21	61	Pipistrellus	Pipistrellus	NNP
cord-295559-yc8q62z8	21	62	pipistrellus	pipistrellus	JJ
cord-295559-yc8q62z8	21	63	bat	bat	NN
cord-295559-yc8q62z8	21	64	in	in	IN
cord-295559-yc8q62z8	21	65	the	the	DT
cord-295559-yc8q62z8	21	66	Netherlands	Netherlands	NNP
cord-295559-yc8q62z8	21	67	[	[	-LRB-
cord-295559-yc8q62z8	21	68	12	12	CD
cord-295559-yc8q62z8	21	69	]	]	-RRB-
cord-295559-yc8q62z8	21	70	.	.	.
cord-295559-yc8q62z8	22	1	Recently	recently	RB
cord-295559-yc8q62z8	22	2	group	group	NN
cord-295559-yc8q62z8	22	3	c	c	NN
cord-295559-yc8q62z8	22	4	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	22	5	were	be	VBD
cord-295559-yc8q62z8	22	6	also	also	RB
cord-295559-yc8q62z8	22	7	detected	detect	VBN
cord-295559-yc8q62z8	22	8	in	in	IN
cord-295559-yc8q62z8	22	9	a	a	DT
cord-295559-yc8q62z8	22	10	Nyctinomops	Nyctinomops	NNP
cord-295559-yc8q62z8	22	11	laticaudatus	laticaudatus	NN
cord-295559-yc8q62z8	22	12	bat	bat	NN
cord-295559-yc8q62z8	22	13	in	in	IN
cord-295559-yc8q62z8	22	14	Mexico	Mexico	NNP
cord-295559-yc8q62z8	22	15	[	[	-LRB-
cord-295559-yc8q62z8	22	16	13	13	CD
cord-295559-yc8q62z8	22	17	]	]	-RRB-
cord-295559-yc8q62z8	22	18	,	,	,
cord-295559-yc8q62z8	22	19	and	and	CC
cord-295559-yc8q62z8	22	20	Nycyteris	Nycyteris	NNP
cord-295559-yc8q62z8	22	21	cf	cf	NNP
cord-295559-yc8q62z8	22	22	.	.	.
cord-295559-yc8q62z8	23	1	gambiensis	gambiensis	NNP
cord-295559-yc8q62z8	23	2	bats	bat	NNS
cord-295559-yc8q62z8	23	3	in	in	IN
cord-295559-yc8q62z8	23	4	Ghana	Ghana	NNP
cord-295559-yc8q62z8	23	5	[	[	-LRB-
cord-295559-yc8q62z8	23	6	14	14	CD
cord-295559-yc8q62z8	23	7	]	]	-RRB-
cord-295559-yc8q62z8	23	8	.	.	.
cord-295559-yc8q62z8	24	1	MERS	MERS	NNP
cord-295559-yc8q62z8	24	2	-	-	HYPH
cord-295559-yc8q62z8	24	3	CoV	CoV	NNP
cord-295559-yc8q62z8	24	4	,	,	,
cord-295559-yc8q62z8	24	5	like	like	IN
cord-295559-yc8q62z8	24	6	SARS	SARS	NNP
cord-295559-yc8q62z8	24	7	-	-	HYPH
cord-295559-yc8q62z8	24	8	CoV	CoV	NNP
cord-295559-yc8q62z8	24	9	,	,	,
cord-295559-yc8q62z8	24	10	is	be	VBZ
cord-295559-yc8q62z8	24	11	probably	probably	RB
cord-295559-yc8q62z8	24	12	a	a	DT
cord-295559-yc8q62z8	24	13	zoonotic	zoonotic	JJ
cord-295559-yc8q62z8	24	14	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	24	15	that	that	WDT
cord-295559-yc8q62z8	24	16	has	have	VBZ
cord-295559-yc8q62z8	24	17	spilled	spill	VBN
cord-295559-yc8q62z8	24	18	over	over	RP
cord-295559-yc8q62z8	24	19	into	into	IN
cord-295559-yc8q62z8	24	20	humans	human	NNS
cord-295559-yc8q62z8	24	21	,	,	,
cord-295559-yc8q62z8	24	22	directly	directly	RB
cord-295559-yc8q62z8	24	23	or	or	CC
cord-295559-yc8q62z8	24	24	indirectly	indirectly	RB
cord-295559-yc8q62z8	24	25	,	,	,
cord-295559-yc8q62z8	24	26	from	from	IN
cord-295559-yc8q62z8	24	27	one	one	CD
cord-295559-yc8q62z8	24	28	of	of	IN
cord-295559-yc8q62z8	24	29	the	the	DT
cord-295559-yc8q62z8	24	30	species	specie	NNS
cord-295559-yc8q62z8	24	31	of	of	IN
cord-295559-yc8q62z8	24	32	bats	bat	NNS
cord-295559-yc8q62z8	24	33	that	that	WDT
cord-295559-yc8q62z8	24	34	harbor	harbor	VBP
cord-295559-yc8q62z8	24	35	group	group	NNP
cord-295559-yc8q62z8	24	36	c	c	NNP
cord-295559-yc8q62z8	24	37	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	24	38	or	or	CC
cord-295559-yc8q62z8	24	39	from	from	IN
cord-295559-yc8q62z8	24	40	other	other	JJ
cord-295559-yc8q62z8	24	41	unknown	unknown	JJ
cord-295559-yc8q62z8	24	42	animal	animal	NN
cord-295559-yc8q62z8	24	43	reservoirs	reservoir	NNS
cord-295559-yc8q62z8	24	44	[	[	-LRB-
cord-295559-yc8q62z8	24	45	13	13	CD
cord-295559-yc8q62z8	24	46	,	,	,
cord-295559-yc8q62z8	24	47	15	15	CD
cord-295559-yc8q62z8	24	48	,	,	,
cord-295559-yc8q62z8	24	49	16	16	CD
cord-295559-yc8q62z8	24	50	]	]	-RRB-
cord-295559-yc8q62z8	24	51	.	.	.
cord-295559-yc8q62z8	25	1	The	the	DT
cord-295559-yc8q62z8	25	2	~200	~200	JJ
cord-295559-yc8q62z8	25	3	kDa	kda	XX
cord-295559-yc8q62z8	25	4	spike	spike	NN
cord-295559-yc8q62z8	25	5	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	25	6	(	(	-LRB-
cord-295559-yc8q62z8	25	7	S	S	NNP
cord-295559-yc8q62z8	25	8	)	)	-RRB-
cord-295559-yc8q62z8	25	9	of	of	IN
cord-295559-yc8q62z8	25	10	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	25	11	is	be	VBZ
cord-295559-yc8q62z8	25	12	an	an	DT
cord-295559-yc8q62z8	25	13	important	important	JJ
cord-295559-yc8q62z8	25	14	determinant	determinant	NN
cord-295559-yc8q62z8	25	15	of	of	IN
cord-295559-yc8q62z8	25	16	virus	virus	NN
cord-295559-yc8q62z8	25	17	virulence	virulence	NN
cord-295559-yc8q62z8	25	18	,	,	,
cord-295559-yc8q62z8	25	19	tissue	tissue	NN
cord-295559-yc8q62z8	25	20	tropism	tropism	NN
cord-295559-yc8q62z8	25	21	and	and	CC
cord-295559-yc8q62z8	25	22	host	host	NN
cord-295559-yc8q62z8	25	23	range	range	NN
cord-295559-yc8q62z8	25	24	.	.	.
cord-295559-yc8q62z8	26	1	Trimers	Trimers	NNP
cord-295559-yc8q62z8	26	2	of	of	IN
cord-295559-yc8q62z8	26	3	S	S	NNP
cord-295559-yc8q62z8	26	4	form	form	NN
cord-295559-yc8q62z8	26	5	the	the	DT
cord-295559-yc8q62z8	26	6	characteristic	characteristic	JJ
cord-295559-yc8q62z8	26	7	large	large	JJ
cord-295559-yc8q62z8	26	8	spikes	spike	NNS
cord-295559-yc8q62z8	26	9	on	on	IN
cord-295559-yc8q62z8	26	10	the	the	DT
cord-295559-yc8q62z8	26	11	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	26	12	envelope	envelope	NN
cord-295559-yc8q62z8	26	13	that	that	WDT
cord-295559-yc8q62z8	26	14	bind	bind	VBP
cord-295559-yc8q62z8	26	15	to	to	IN
cord-295559-yc8q62z8	26	16	receptors	receptor	NNS
cord-295559-yc8q62z8	26	17	,	,	,
cord-295559-yc8q62z8	26	18	mediate	mediate	VB
cord-295559-yc8q62z8	26	19	membrane	membrane	NN
cord-295559-yc8q62z8	26	20	fusion	fusion	NN
cord-295559-yc8q62z8	26	21	,	,	,
cord-295559-yc8q62z8	26	22	virus	virus	NN
cord-295559-yc8q62z8	26	23	entry	entry	NN
cord-295559-yc8q62z8	26	24	and	and	CC
cord-295559-yc8q62z8	26	25	syncytia	syncytia	NN
cord-295559-yc8q62z8	26	26	formation	formation	NN
cord-295559-yc8q62z8	26	27	,	,	,
cord-295559-yc8q62z8	26	28	and	and	CC
cord-295559-yc8q62z8	26	29	elicit	elicit	VB
cord-295559-yc8q62z8	26	30	virus	virus	NN
cord-295559-yc8q62z8	26	31	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	26	32	antibodies	antibody	NNS
cord-295559-yc8q62z8	26	33	.	.	.
cord-295559-yc8q62z8	27	1	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	27	2	S	S	NNP
cord-295559-yc8q62z8	27	3	proteins	protein	NNS
cord-295559-yc8q62z8	27	4	are	be	VBP
cord-295559-yc8q62z8	27	5	Class	class	NN
cord-295559-yc8q62z8	27	6	I	-PRON-	PRP
cord-295559-yc8q62z8	27	7	viral	viral	JJ
cord-295559-yc8q62z8	27	8	fusion	fusion	NN
cord-295559-yc8q62z8	27	9	proteins	protein	NNS
cord-295559-yc8q62z8	27	10	like	like	IN
cord-295559-yc8q62z8	27	11	the	the	DT
cord-295559-yc8q62z8	27	12	HIV	HIV	NNP
cord-295559-yc8q62z8	27	13	envelope	envelope	NN
cord-295559-yc8q62z8	27	14	(	(	-LRB-
cord-295559-yc8q62z8	27	15	env	env	NNP
cord-295559-yc8q62z8	27	16	)	)	-RRB-
cord-295559-yc8q62z8	27	17	,	,	,
cord-295559-yc8q62z8	27	18	influenza	influenza	NN
cord-295559-yc8q62z8	27	19	hemagglutinin	hemagglutinin	NNP
cord-295559-yc8q62z8	27	20	(	(	-LRB-
cord-295559-yc8q62z8	27	21	HA	HA	NNP
cord-295559-yc8q62z8	27	22	)	)	-RRB-
cord-295559-yc8q62z8	27	23	and	and	CC
cord-295559-yc8q62z8	27	24	paramyxovirus	paramyxovirus	JJ
cord-295559-yc8q62z8	27	25	fusion	fusion	NN
cord-295559-yc8q62z8	27	26	(	(	-LRB-
cord-295559-yc8q62z8	27	27	F	F	NNP
cord-295559-yc8q62z8	27	28	)	)	-RRB-
cord-295559-yc8q62z8	27	29	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	27	30	[	[	-LRB-
cord-295559-yc8q62z8	27	31	17	17	CD
cord-295559-yc8q62z8	27	32	]	]	-RRB-
cord-295559-yc8q62z8	27	33	,	,	,
cord-295559-yc8q62z8	27	34	which	which	WDT
cord-295559-yc8q62z8	27	35	typically	typically	RB
cord-295559-yc8q62z8	27	36	require	require	VBP
cord-295559-yc8q62z8	27	37	protease	protease	NN
cord-295559-yc8q62z8	27	38	cleavage	cleavage	NN
cord-295559-yc8q62z8	27	39	between	between	IN
cord-295559-yc8q62z8	27	40	the	the	DT
cord-295559-yc8q62z8	27	41	S1	S1	NNP
cord-295559-yc8q62z8	27	42	and	and	CC
cord-295559-yc8q62z8	27	43	S2	s2	NN
cord-295559-yc8q62z8	27	44	domains	domain	NNS
cord-295559-yc8q62z8	27	45	(	(	-LRB-
cord-295559-yc8q62z8	27	46	Figure	figure	NN
cord-295559-yc8q62z8	27	47	1A	1a	NN
cord-295559-yc8q62z8	27	48	)	)	-RRB-
cord-295559-yc8q62z8	27	49	to	to	TO
cord-295559-yc8q62z8	27	50	permit	permit	VB
cord-295559-yc8q62z8	27	51	conformational	conformational	JJ
cord-295559-yc8q62z8	27	52	changes	change	NNS
cord-295559-yc8q62z8	27	53	in	in	IN
cord-295559-yc8q62z8	27	54	S2	S2	NNP
cord-295559-yc8q62z8	27	55	,	,	,
cord-295559-yc8q62z8	27	56	activated	activate	VBN
cord-295559-yc8q62z8	27	57	by	by	IN
cord-295559-yc8q62z8	27	58	receptor	receptor	NN
cord-295559-yc8q62z8	27	59	binding	binding	NN
cord-295559-yc8q62z8	27	60	and/or	and/or	CC
cord-295559-yc8q62z8	27	61	low	low	JJ
cord-295559-yc8q62z8	27	62	pH	ph	NN
cord-295559-yc8q62z8	27	63	,	,	,
cord-295559-yc8q62z8	27	64	that	that	WDT
cord-295559-yc8q62z8	27	65	mediate	mediate	VBP
cord-295559-yc8q62z8	27	66	membrane	membrane	NN
cord-295559-yc8q62z8	27	67	fusion	fusion	NN
cord-295559-yc8q62z8	27	68	leading	lead	VBG
cord-295559-yc8q62z8	27	69	to	to	IN
cord-295559-yc8q62z8	27	70	virus	virus	NN
cord-295559-yc8q62z8	27	71	entry	entry	NN
cord-295559-yc8q62z8	27	72	and	and	CC
cord-295559-yc8q62z8	27	73	syncytia	syncytia	NN
cord-295559-yc8q62z8	27	74	formation	formation	NN
cord-295559-yc8q62z8	27	75	[	[	-LRB-
cord-295559-yc8q62z8	27	76	3	3	CD
cord-295559-yc8q62z8	27	77	,	,	,
cord-295559-yc8q62z8	27	78	17	17	CD
cord-295559-yc8q62z8	27	79	,	,	,
cord-295559-yc8q62z8	27	80	18	18	CD
cord-295559-yc8q62z8	27	81	]	]	-RRB-
cord-295559-yc8q62z8	27	82	.	.	.
cord-295559-yc8q62z8	28	1	In	in	IN
cord-295559-yc8q62z8	28	2	different	different	JJ
cord-295559-yc8q62z8	28	3	cell	cell	NN
cord-295559-yc8q62z8	28	4	types	type	NNS
cord-295559-yc8q62z8	28	5	and	and	CC
cord-295559-yc8q62z8	28	6	tissues	tissue	NNS
cord-295559-yc8q62z8	28	7	,	,	,
cord-295559-yc8q62z8	28	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	28	9	S	s	NN
cord-295559-yc8q62z8	28	10	proteins	protein	NNS
cord-295559-yc8q62z8	28	11	may	may	MD
cord-295559-yc8q62z8	28	12	be	be	VB
cord-295559-yc8q62z8	28	13	cleaved	cleave	VBN
cord-295559-yc8q62z8	28	14	by	by	IN
cord-295559-yc8q62z8	28	15	a	a	DT
cord-295559-yc8q62z8	28	16	variety	variety	NN
cord-295559-yc8q62z8	28	17	of	of	IN
cord-295559-yc8q62z8	28	18	host	host	NN
cord-295559-yc8q62z8	28	19	proteases	protease	NNS
cord-295559-yc8q62z8	28	20	including	include	VBG
cord-295559-yc8q62z8	28	21	furin	furin	NN
cord-295559-yc8q62z8	28	22	,	,	,
cord-295559-yc8q62z8	28	23	trypsin	trypsin	NN
cord-295559-yc8q62z8	28	24	,	,	,
cord-295559-yc8q62z8	28	25	human	human	JJ
cord-295559-yc8q62z8	28	26	airway	airway	NN
cord-295559-yc8q62z8	28	27	trypsin	trypsin	NN
cord-295559-yc8q62z8	28	28	-	-	HYPH
cord-295559-yc8q62z8	28	29	like	like	JJ
cord-295559-yc8q62z8	28	30	protease	protease	NN
cord-295559-yc8q62z8	28	31	(	(	-LRB-
cord-295559-yc8q62z8	28	32	HAT	hat	NN
cord-295559-yc8q62z8	28	33	)	)	-RRB-
cord-295559-yc8q62z8	28	34	,	,	,
cord-295559-yc8q62z8	28	35	transmembrane	transmembrane	NN
cord-295559-yc8q62z8	28	36	protease	protease	NN
cord-295559-yc8q62z8	28	37	serine	serine	NN
cord-295559-yc8q62z8	28	38	protease-2	protease-2	NNP
cord-295559-yc8q62z8	28	39	(	(	-LRB-
cord-295559-yc8q62z8	28	40	TMPRSS-2	TMPRSS-2	NNP
cord-295559-yc8q62z8	28	41	)	)	-RRB-
cord-295559-yc8q62z8	28	42	,	,	,
cord-295559-yc8q62z8	28	43	TMPRSS-4	TMPRSS-4	NNP
cord-295559-yc8q62z8	28	44	,	,	,
cord-295559-yc8q62z8	28	45	or	or	CC
cord-295559-yc8q62z8	28	46	cathepsins	cathepsin	NNS
cord-295559-yc8q62z8	28	47	[	[	-LRB-
cord-295559-yc8q62z8	28	48	18	18	CD
cord-295559-yc8q62z8	28	49	]	]	-RRB-
cord-295559-yc8q62z8	28	50	[	[	-LRB-
cord-295559-yc8q62z8	28	51	19	19	CD
cord-295559-yc8q62z8	28	52	]	]	-RRB-
cord-295559-yc8q62z8	28	53	[	[	-LRB-
cord-295559-yc8q62z8	28	54	20	20	CD
cord-295559-yc8q62z8	28	55	]	]	-RRB-
cord-295559-yc8q62z8	28	56	[	[	-LRB-
cord-295559-yc8q62z8	28	57	21	21	CD
cord-295559-yc8q62z8	28	58	]	]	-RRB-
cord-295559-yc8q62z8	28	59	[	[	-LRB-
cord-295559-yc8q62z8	28	60	22	22	CD
cord-295559-yc8q62z8	28	61	]	]	-RRB-
cord-295559-yc8q62z8	28	62	.	.	.
cord-295559-yc8q62z8	29	1	Functional	functional	JJ
cord-295559-yc8q62z8	29	2	analysis	analysis	NN
cord-295559-yc8q62z8	29	3	of	of	IN
cord-295559-yc8q62z8	29	4	MERS	MERS	NNP
cord-295559-yc8q62z8	29	5	-	-	HYPH
cord-295559-yc8q62z8	29	6	CoV	CoV	NNP
cord-295559-yc8q62z8	29	7	S	S	NNP
cord-295559-yc8q62z8	29	8	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	29	9	is	be	VBZ
cord-295559-yc8q62z8	29	10	needed	need	VBN
cord-295559-yc8q62z8	29	11	to	to	TO
cord-295559-yc8q62z8	29	12	identify	identify	VB
cord-295559-yc8q62z8	29	13	susceptible	susceptible	JJ
cord-295559-yc8q62z8	29	14	cell	cell	NN
cord-295559-yc8q62z8	29	15	types	type	NNS
cord-295559-yc8q62z8	29	16	and	and	CC
cord-295559-yc8q62z8	29	17	host	host	NN
cord-295559-yc8q62z8	29	18	species	specie	NNS
cord-295559-yc8q62z8	29	19	that	that	WDT
cord-295559-yc8q62z8	29	20	affect	affect	VBP
cord-295559-yc8q62z8	29	21	viral	viral	JJ
cord-295559-yc8q62z8	29	22	tissue	tissue	NN
cord-295559-yc8q62z8	29	23	tropism	tropism	NN
cord-295559-yc8q62z8	29	24	and	and	CC
cord-295559-yc8q62z8	29	25	host	host	NN
cord-295559-yc8q62z8	29	26	range	range	NN
cord-295559-yc8q62z8	29	27	,	,	,
cord-295559-yc8q62z8	29	28	and	and	CC
cord-295559-yc8q62z8	29	29	to	to	TO
cord-295559-yc8q62z8	29	30	determine	determine	VB
cord-295559-yc8q62z8	29	31	how	how	WRB
cord-295559-yc8q62z8	29	32	various	various	JJ
cord-295559-yc8q62z8	29	33	host	host	NN
cord-295559-yc8q62z8	29	34	proteases	protease	NNS
cord-295559-yc8q62z8	29	35	promote	promote	VBP
cord-295559-yc8q62z8	29	36	MERS	MERS	NNP
cord-295559-yc8q62z8	29	37	-	-	HYPH
cord-295559-yc8q62z8	29	38	CoV	CoV	NNP
cord-295559-yc8q62z8	29	39	virus	virus	NN
cord-295559-yc8q62z8	29	40	entry	entry	NN
cord-295559-yc8q62z8	29	41	and	and	CC
cord-295559-yc8q62z8	29	42	syncytia	syncytia	NN
cord-295559-yc8q62z8	29	43	formation	formation	NN
cord-295559-yc8q62z8	29	44	.	.	.
cord-295559-yc8q62z8	30	1	Identification	identification	NN
cord-295559-yc8q62z8	30	2	of	of	IN
cord-295559-yc8q62z8	30	3	the	the	DT
cord-295559-yc8q62z8	30	4	receptor	receptor	NN
cord-295559-yc8q62z8	30	5	or	or	CC
cord-295559-yc8q62z8	30	6	receptors	receptor	NNS
cord-295559-yc8q62z8	30	7	is	be	VBZ
cord-295559-yc8q62z8	30	8	an	an	DT
cord-295559-yc8q62z8	30	9	important	important	JJ
cord-295559-yc8q62z8	30	10	first	first	JJ
cord-295559-yc8q62z8	30	11	step	step	NN
cord-295559-yc8q62z8	30	12	in	in	IN
cord-295559-yc8q62z8	30	13	understanding	understand	VBG
cord-295559-yc8q62z8	30	14	the	the	DT
cord-295559-yc8q62z8	30	15	host	host	NN
cord-295559-yc8q62z8	30	16	range	range	NN
cord-295559-yc8q62z8	30	17	and	and	CC
cord-295559-yc8q62z8	30	18	tissue	tissue	NN
cord-295559-yc8q62z8	30	19	tropism	tropism	NN
cord-295559-yc8q62z8	30	20	of	of	IN
cord-295559-yc8q62z8	30	21	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	30	22	.	.	.
cord-295559-yc8q62z8	31	1	Four	four	CD
cord-295559-yc8q62z8	31	2	receptor	receptor	NN
cord-295559-yc8q62z8	31	3	proteins	protein	NNS
cord-295559-yc8q62z8	31	4	for	for	IN
cord-295559-yc8q62z8	31	5	spike	spike	NN
cord-295559-yc8q62z8	31	6	proteins	protein	NNS
cord-295559-yc8q62z8	31	7	of	of	IN
cord-295559-yc8q62z8	31	8	different	different	JJ
cord-295559-yc8q62z8	31	9	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	31	10	are	be	VBP
cord-295559-yc8q62z8	31	11	now	now	RB
cord-295559-yc8q62z8	31	12	known	know	VBN
cord-295559-yc8q62z8	31	13	:	:	:
cord-295559-yc8q62z8	32	1	murine	murine	JJ
cord-295559-yc8q62z8	32	2	carcinoembryonic	carcinoembryonic	NNP
cord-295559-yc8q62z8	32	3	antigen	antigen	NN
cord-295559-yc8q62z8	32	4	cell	cell	NN
cord-295559-yc8q62z8	32	5	adhesion	adhesion	NN
cord-295559-yc8q62z8	32	6	molecule	molecule	NN
cord-295559-yc8q62z8	32	7	1a	1a	CD
cord-295559-yc8q62z8	32	8	(	(	-LRB-
cord-295559-yc8q62z8	32	9	mCEACAM1a	mCEACAM1a	NNP
cord-295559-yc8q62z8	32	10	)	)	-RRB-
cord-295559-yc8q62z8	32	11	for	for	IN
cord-295559-yc8q62z8	32	12	mouse	mouse	NNP
cord-295559-yc8q62z8	32	13	hepatitis	hepatitis	NNP
cord-295559-yc8q62z8	32	14	virus	virus	NN
cord-295559-yc8q62z8	32	15	(	(	-LRB-
cord-295559-yc8q62z8	32	16	MHV	mhv	NN
cord-295559-yc8q62z8	32	17	)	)	-RRB-
cord-295559-yc8q62z8	33	1	[	[	-LRB-
cord-295559-yc8q62z8	33	2	23	23	CD
cord-295559-yc8q62z8	33	3	]	]	-RRB-
cord-295559-yc8q62z8	33	4	,	,	,
cord-295559-yc8q62z8	33	5	a	a	DT
cord-295559-yc8q62z8	33	6	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	33	7	in	in	IN
cord-295559-yc8q62z8	33	8	group	group	NN
cord-295559-yc8q62z8	33	9	a	a	DT
cord-295559-yc8q62z8	33	10	;	;	:
cord-295559-yc8q62z8	33	11	aminopeptidase	aminopeptidase	NN
cord-295559-yc8q62z8	33	12	N	n	CD
cord-295559-yc8q62z8	33	13	(	(	-LRB-
cord-295559-yc8q62z8	33	14	APN	APN	NNP
cord-295559-yc8q62z8	33	15	)	)	-RRB-
cord-295559-yc8q62z8	33	16	for	for	IN
cord-295559-yc8q62z8	33	17	human	human	JJ
cord-295559-yc8q62z8	33	18	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	33	19	229E	229e	CD
cord-295559-yc8q62z8	33	20	(	(	-LRB-
cord-295559-yc8q62z8	33	21	HCoV-229E	HCoV-229E	NNP
cord-295559-yc8q62z8	33	22	)	)	-RRB-
cord-295559-yc8q62z8	33	23	and	and	CC
cord-295559-yc8q62z8	33	24	several	several	JJ
cord-295559-yc8q62z8	33	25	other	other	JJ
cord-295559-yc8q62z8	33	26	alphacoronaviruses	alphacoronaviruse	NNS
cord-295559-yc8q62z8	33	27	[	[	-LRB-
cord-295559-yc8q62z8	33	28	24	24	CD
cord-295559-yc8q62z8	33	29	,	,	,
cord-295559-yc8q62z8	33	30	25	25	CD
cord-295559-yc8q62z8	33	31	]	]	-RRB-
cord-295559-yc8q62z8	33	32	;	;	:
cord-295559-yc8q62z8	33	33	and	and	CC
cord-295559-yc8q62z8	33	34	angiotensin	angiotensin	NN
cord-295559-yc8q62z8	33	35	-	-	HYPH
cord-295559-yc8q62z8	33	36	converting	convert	VBG
cord-295559-yc8q62z8	33	37	enzyme	enzyme	NN
cord-295559-yc8q62z8	33	38	2	2	CD
cord-295559-yc8q62z8	34	1	(	(	-LRB-
cord-295559-yc8q62z8	34	2	ACE2	ACE2	NNP
cord-295559-yc8q62z8	34	3	)	)	-RRB-
cord-295559-yc8q62z8	34	4	for	for	IN
cord-295559-yc8q62z8	34	5	both	both	DT
cord-295559-yc8q62z8	34	6	SARS	SARS	NNP
cord-295559-yc8q62z8	34	7	-	-	HYPH
cord-295559-yc8q62z8	34	8	CoV	CoV	NNP
cord-295559-yc8q62z8	34	9	,	,	,
cord-295559-yc8q62z8	34	10	a	a	DT
cord-295559-yc8q62z8	34	11	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	34	12	in	in	IN
cord-295559-yc8q62z8	34	13	group	group	NN
cord-295559-yc8q62z8	34	14	b	b	NNP
cord-295559-yc8q62z8	34	15	and	and	CC
cord-295559-yc8q62z8	34	16	HCoV	HCoV	NNP
cord-295559-yc8q62z8	34	17	-	-	HYPH
cord-295559-yc8q62z8	34	18	NL63	NL63	NNP
cord-295559-yc8q62z8	34	19	,	,	,
cord-295559-yc8q62z8	34	20	an	an	DT
cord-295559-yc8q62z8	34	21	alphacoronavirus	alphacoronavirus	NNP
cord-295559-yc8q62z8	34	22	[	[	-LRB-
cord-295559-yc8q62z8	34	23	26	26	CD
cord-295559-yc8q62z8	34	24	,	,	,
cord-295559-yc8q62z8	34	25	27	27	CD
cord-295559-yc8q62z8	34	26	]	]	-RRB-
cord-295559-yc8q62z8	34	27	.	.	.
cord-295559-yc8q62z8	35	1	Raj	Raj	NNP
cord-295559-yc8q62z8	35	2	and	and	CC
cord-295559-yc8q62z8	35	3	co	co	NNS
cord-295559-yc8q62z8	35	4	-	-	NNS
cord-295559-yc8q62z8	35	5	workers	worker	NNS
cord-295559-yc8q62z8	35	6	[	[	-LRB-
cord-295559-yc8q62z8	35	7	28	28	CD
cord-295559-yc8q62z8	35	8	]	]	-RRB-
cord-295559-yc8q62z8	35	9	recently	recently	RB
cord-295559-yc8q62z8	35	10	demonstrated	demonstrate	VBD
cord-295559-yc8q62z8	35	11	that	that	IN
cord-295559-yc8q62z8	35	12	MERS	MERS	NNP
cord-295559-yc8q62z8	35	13	-	-	HYPH
cord-295559-yc8q62z8	35	14	CoV	CoV	NNP
cord-295559-yc8q62z8	35	15	uses	use	VBZ
cord-295559-yc8q62z8	35	16	dipeptidyl	dipeptidyl	JJ
cord-295559-yc8q62z8	35	17	peptidase	peptidase	NN
cord-295559-yc8q62z8	35	18	4	4	CD
cord-295559-yc8q62z8	35	19	(	(	-LRB-
cord-295559-yc8q62z8	35	20	DPP4	DPP4	NNP
cord-295559-yc8q62z8	35	21	)	)	-RRB-
cord-295559-yc8q62z8	35	22	as	as	IN
cord-295559-yc8q62z8	35	23	a	a	DT
cord-295559-yc8q62z8	35	24	receptor	receptor	NN
cord-295559-yc8q62z8	35	25	.	.	.
cord-295559-yc8q62z8	36	1	In	in	IN
cord-295559-yc8q62z8	36	2	contrast	contrast	NN
cord-295559-yc8q62z8	36	3	,	,	,
cord-295559-yc8q62z8	36	4	S	s	NN
cord-295559-yc8q62z8	36	5	proteins	protein	NNS
cord-295559-yc8q62z8	36	6	of	of	IN
cord-295559-yc8q62z8	36	7	several	several	JJ
cord-295559-yc8q62z8	36	8	group	group	NN
cord-295559-yc8q62z8	36	9	a	a	DT
cord-295559-yc8q62z8	36	10	betacoronaviruses	betacoronaviruse	NNS
cord-295559-yc8q62z8	36	11	including	include	VBG
cord-295559-yc8q62z8	36	12	bovine	bovine	JJ
cord-295559-yc8q62z8	36	13	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	36	14	and	and	CC
cord-295559-yc8q62z8	36	15	hCoV	hcov	NN
cord-295559-yc8q62z8	36	16	-	-	HYPH
cord-295559-yc8q62z8	36	17	OC43	OC43	NNP
cord-295559-yc8q62z8	36	18	use	use	VB
cord-295559-yc8q62z8	36	19	sialic	sialic	NN
cord-295559-yc8q62z8	36	20	acid	acid	NN
cord-295559-yc8q62z8	36	21	moieties	moiety	NNS
cord-295559-yc8q62z8	36	22	as	as	IN
cord-295559-yc8q62z8	36	23	receptors	receptor	NNS
cord-295559-yc8q62z8	36	24	[	[	-LRB-
cord-295559-yc8q62z8	36	25	29	29	CD
cord-295559-yc8q62z8	36	26	,	,	,
cord-295559-yc8q62z8	36	27	58	58	CD
cord-295559-yc8q62z8	36	28	]	]	-RRB-
cord-295559-yc8q62z8	36	29	.	.	.
cord-295559-yc8q62z8	37	1	We	-PRON-	PRP
cord-295559-yc8q62z8	37	2	have	have	VBP
cord-295559-yc8q62z8	37	3	used	use	VBN
cord-295559-yc8q62z8	37	4	lentivirus	lentivirus	NN
cord-295559-yc8q62z8	37	5	pseudotypes	pseudotype	NNS
cord-295559-yc8q62z8	37	6	with	with	IN
cord-295559-yc8q62z8	37	7	MERS	MERS	NNP
cord-295559-yc8q62z8	37	8	-	-	HYPH
cord-295559-yc8q62z8	37	9	CoV	cov	NN
cord-295559-yc8q62z8	37	10	spike	spike	NN
cord-295559-yc8q62z8	37	11	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	37	12	to	to	TO
cord-295559-yc8q62z8	37	13	identify	identify	VB
cord-295559-yc8q62z8	37	14	cells	cell	NNS
cord-295559-yc8q62z8	37	15	susceptible	susceptible	JJ
cord-295559-yc8q62z8	37	16	to	to	IN
cord-295559-yc8q62z8	37	17	infection	infection	NN
cord-295559-yc8q62z8	37	18	with	with	IN
cord-295559-yc8q62z8	37	19	MERS	MERS	NNP
cord-295559-yc8q62z8	37	20	-	-	HYPH
cord-295559-yc8q62z8	37	21	CoV	CoV	NNP
cord-295559-yc8q62z8	37	22	and	and	CC
cord-295559-yc8q62z8	37	23	to	to	TO
cord-295559-yc8q62z8	37	24	study	study	VB
cord-295559-yc8q62z8	37	25	the	the	DT
cord-295559-yc8q62z8	37	26	role	role	NN
cord-295559-yc8q62z8	37	27	of	of	IN
cord-295559-yc8q62z8	37	28	MERS	MERS	NNP
cord-295559-yc8q62z8	37	29	S	S	NNP
cord-295559-yc8q62z8	37	30	protein	protein	NN
cord-295559-yc8q62z8	37	31	in	in	IN
cord-295559-yc8q62z8	37	32	virus	virus	NN
cord-295559-yc8q62z8	37	33	entry	entry	NN
cord-295559-yc8q62z8	37	34	and	and	CC
cord-295559-yc8q62z8	37	35	syncytia	syncytia	NN
cord-295559-yc8q62z8	37	36	formation	formation	NN
cord-295559-yc8q62z8	37	37	.	.	.
cord-295559-yc8q62z8	38	1	Expression	expression	NN
cord-295559-yc8q62z8	38	2	of	of	IN
cord-295559-yc8q62z8	38	3	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	38	4	S	s	NN
cord-295559-yc8q62z8	38	5	proteins	protein	NNS
cord-295559-yc8q62z8	38	6	on	on	IN
cord-295559-yc8q62z8	38	7	293	293	CD
cord-295559-yc8q62z8	38	8	T	t	NN
cord-295559-yc8q62z8	38	9	cell	cell	NN
cord-295559-yc8q62z8	38	10	membranes	membrane	NNS
cord-295559-yc8q62z8	38	11	for	for	IN
cord-295559-yc8q62z8	38	12	incorporation	incorporation	NN
cord-295559-yc8q62z8	38	13	into	into	IN
cord-295559-yc8q62z8	38	14	lentivirus	lentivirus	NN
cord-295559-yc8q62z8	38	15	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	38	16	can	can	MD
cord-295559-yc8q62z8	38	17	be	be	VB
cord-295559-yc8q62z8	38	18	enhanced	enhance	VBN
cord-295559-yc8q62z8	38	19	by	by	IN
cord-295559-yc8q62z8	38	20	using	use	VBG
cord-295559-yc8q62z8	38	21	codon	codon	NN
cord-295559-yc8q62z8	38	22	-	-	HYPH
cord-295559-yc8q62z8	38	23	optimized	optimize	VBN
cord-295559-yc8q62z8	38	24	spike	spike	NN
cord-295559-yc8q62z8	38	25	cDNA	cdna	NN
cord-295559-yc8q62z8	38	26	and	and	CC
cord-295559-yc8q62z8	38	27	deleting	delete	VBG
cord-295559-yc8q62z8	38	28	an	an	DT
cord-295559-yc8q62z8	38	29	ER	ER	NNP
cord-295559-yc8q62z8	38	30	/	/	SYM
cord-295559-yc8q62z8	38	31	Golgi	Golgi	NNP
cord-295559-yc8q62z8	38	32	retention	retention	NN
cord-295559-yc8q62z8	38	33	motif	motif	NN
cord-295559-yc8q62z8	38	34	and	and	CC
cord-295559-yc8q62z8	38	35	an	an	DT
cord-295559-yc8q62z8	38	36	endosomal	endosomal	JJ
cord-295559-yc8q62z8	38	37	recycling	recycling	NN
cord-295559-yc8q62z8	38	38	motif	motif	NN
cord-295559-yc8q62z8	38	39	from	from	IN
cord-295559-yc8q62z8	38	40	the	the	DT
cord-295559-yc8q62z8	38	41	cytoplasmic	cytoplasmic	JJ
cord-295559-yc8q62z8	38	42	tail	tail	NN
cord-295559-yc8q62z8	38	43	of	of	IN
cord-295559-yc8q62z8	38	44	S	s	NN
cord-295559-yc8q62z8	38	45	[	[	-LRB-
cord-295559-yc8q62z8	38	46	30	30	CD
cord-295559-yc8q62z8	38	47	]	]	-RRB-
cord-295559-yc8q62z8	38	48	[	[	-LRB-
cord-295559-yc8q62z8	38	49	31	31	CD
cord-295559-yc8q62z8	38	50	]	]	-RRB-
cord-295559-yc8q62z8	38	51	[	[	-LRB-
cord-295559-yc8q62z8	38	52	32	32	CD
cord-295559-yc8q62z8	38	53	]	]	-RRB-
cord-295559-yc8q62z8	38	54	.	.	.
cord-295559-yc8q62z8	39	1	Codonoptimized	Codonoptimized	NNP
cord-295559-yc8q62z8	39	2	cDNA	cdna	NN
cord-295559-yc8q62z8	39	3	encoding	encode	VBG
cord-295559-yc8q62z8	39	4	S	S	NNP
cord-295559-yc8q62z8	39	5	of	of	IN
cord-295559-yc8q62z8	39	6	MERS	MERS	NNP
cord-295559-yc8q62z8	39	7	-	-	HYPH
cord-295559-yc8q62z8	39	8	CoV	CoV	NNP
cord-295559-yc8q62z8	39	9	(	(	-LRB-
cord-295559-yc8q62z8	39	10	derived	derive	VBN
cord-295559-yc8q62z8	39	11	from	from	IN
cord-295559-yc8q62z8	39	12	GenBank	GenBank	NNP
cord-295559-yc8q62z8	39	13	:	:	:
cord-295559-yc8q62z8	40	1	AFS88936	AFS88936	NNP
cord-295559-yc8q62z8	40	2	)	)	-RRB-
cord-295559-yc8q62z8	40	3	[	[	-LRB-
cord-295559-yc8q62z8	40	4	15	15	CD
cord-295559-yc8q62z8	40	5	]	]	-RRB-
cord-295559-yc8q62z8	40	6	,	,	,
cord-295559-yc8q62z8	40	7	with	with	IN
cord-295559-yc8q62z8	40	8	the	the	DT
cord-295559-yc8q62z8	40	9	16	16	CD
cord-295559-yc8q62z8	40	10	C	c	NN
cord-295559-yc8q62z8	40	11	-	-	HYPH
cord-295559-yc8q62z8	40	12	terminal	terminal	NN
cord-295559-yc8q62z8	40	13	amino	amino	NN
cord-295559-yc8q62z8	40	14	acids	acid	NNS
cord-295559-yc8q62z8	40	15	replaced	replace	VBN
cord-295559-yc8q62z8	40	16	by	by	IN
cord-295559-yc8q62z8	40	17	a	a	DT
cord-295559-yc8q62z8	40	18	linker	linker	NN
cord-295559-yc8q62z8	40	19	,	,	,
cord-295559-yc8q62z8	40	20	GGGGS	GGGGS	NNP
cord-295559-yc8q62z8	40	21	,	,	,
cord-295559-yc8q62z8	40	22	and	and	CC
cord-295559-yc8q62z8	40	23	a	a	DT
cord-295559-yc8q62z8	40	24	FLAG	flag	NN
cord-295559-yc8q62z8	40	25	tag	tag	NN
cord-295559-yc8q62z8	40	26	(	(	-LRB-
cord-295559-yc8q62z8	40	27	here	here	RB
cord-295559-yc8q62z8	40	28	called	call	VBN
cord-295559-yc8q62z8	40	29	MERS	MERS	NNP
cord-295559-yc8q62z8	40	30	-	-	HYPH
cord-295559-yc8q62z8	40	31	CoV	cov	NN
cord-295559-yc8q62z8	40	32	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	40	33	)	)	-RRB-
cord-295559-yc8q62z8	41	1	(	(	-LRB-
cord-295559-yc8q62z8	41	2	Figure	figure	NN
cord-295559-yc8q62z8	41	3	1A	1a	NN
cord-295559-yc8q62z8	41	4	)	)	-RRB-
cord-295559-yc8q62z8	41	5	was	be	VBD
cord-295559-yc8q62z8	41	6	expressed	express	VBN
cord-295559-yc8q62z8	41	7	on	on	IN
cord-295559-yc8q62z8	41	8	293	293	CD
cord-295559-yc8q62z8	41	9	T	T	NNP
cord-295559-yc8q62z8	41	10	cell	cell	NN
cord-295559-yc8q62z8	41	11	Figure	figure	NN
cord-295559-yc8q62z8	41	12	1B	1b	NN
cord-295559-yc8q62z8	41	13	,	,	,
cord-295559-yc8q62z8	41	14	lane	lane	NN
cord-295559-yc8q62z8	41	15	2	2	CD
cord-295559-yc8q62z8	41	16	)	)	-RRB-
cord-295559-yc8q62z8	41	17	.	.	.
cord-295559-yc8q62z8	42	1	No	no	DT
cord-295559-yc8q62z8	42	2	protease	protease	NN
cord-295559-yc8q62z8	42	3	cleavage	cleavage	NN
cord-295559-yc8q62z8	42	4	products	product	NNS
cord-295559-yc8q62z8	42	5	of	of	IN
cord-295559-yc8q62z8	42	6	the	the	DT
cord-295559-yc8q62z8	42	7	~200kDa	~200kDa	NNP
cord-295559-yc8q62z8	42	8	S	s	NN
cord-295559-yc8q62z8	42	9	protein	protein	NN
cord-295559-yc8q62z8	42	10	were	be	VBD
cord-295559-yc8q62z8	42	11	detected	detect	VBN
cord-295559-yc8q62z8	42	12	in	in	IN
cord-295559-yc8q62z8	42	13	transfected	transfecte	VBN
cord-295559-yc8q62z8	42	14	293	293	CD
cord-295559-yc8q62z8	42	15	T	T	NNP
cord-295559-yc8q62z8	42	16	cells	cell	NNS
cord-295559-yc8q62z8	42	17	or	or	CC
cord-295559-yc8q62z8	42	18	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	42	19	(	(	-LRB-
cord-295559-yc8q62z8	42	20	Figure	figure	NN
cord-295559-yc8q62z8	42	21	1B	1b	CD
cord-295559-yc8q62z8	42	22	)	)	-RRB-
cord-295559-yc8q62z8	42	23	.	.	.
cord-295559-yc8q62z8	43	1	In	in	IN
cord-295559-yc8q62z8	43	2	marked	marked	JJ
cord-295559-yc8q62z8	43	3	contrast	contrast	NN
cord-295559-yc8q62z8	43	4	,	,	,
cord-295559-yc8q62z8	43	5	the	the	DT
cord-295559-yc8q62z8	43	6	MERS	MERS	NNP
cord-295559-yc8q62z8	43	7	lentivirus	lentivirus	NN
cord-295559-yc8q62z8	43	8	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	43	9	used	use	VBN
cord-295559-yc8q62z8	43	10	to	to	TO
cord-295559-yc8q62z8	43	11	identify	identify	VB
cord-295559-yc8q62z8	43	12	cells	cell	NNS
cord-295559-yc8q62z8	43	13	susceptible	susceptible	JJ
cord-295559-yc8q62z8	43	14	to	to	IN
cord-295559-yc8q62z8	43	15	entry	entry	NN
cord-295559-yc8q62z8	43	16	of	of	IN
cord-295559-yc8q62z8	43	17	MERS	MERS	NNP
cord-295559-yc8q62z8	43	18	-	-	HYPH
cord-295559-yc8q62z8	43	19	CoV	CoV	NNP
cord-295559-yc8q62z8	43	20	in	in	IN
cord-295559-yc8q62z8	43	21	the	the	DT
cord-295559-yc8q62z8	43	22	Poehlmann	Poehlmann	NNP
cord-295559-yc8q62z8	43	23	laboratory	laboratory	NN
cord-295559-yc8q62z8	43	24	[	[	-LRB-
cord-295559-yc8q62z8	43	25	33	33	CD
cord-295559-yc8q62z8	43	26	]	]	-RRB-
cord-295559-yc8q62z8	43	27	,	,	,
cord-295559-yc8q62z8	43	28	contained	contain	VBD
cord-295559-yc8q62z8	43	29	a	a	DT
cord-295559-yc8q62z8	43	30	high	high	JJ
cord-295559-yc8q62z8	43	31	proportion	proportion	NN
cord-295559-yc8q62z8	43	32	of	of	IN
cord-295559-yc8q62z8	43	33	cleaved	cleaved	JJ
cord-295559-yc8q62z8	43	34	MERS	MERS	NNP
cord-295559-yc8q62z8	43	35	-	-	HYPH
cord-295559-yc8q62z8	43	36	CoV	CoV	NNP
cord-295559-yc8q62z8	43	37	S	S	NNP
cord-295559-yc8q62z8	43	38	protein	protein	NN
cord-295559-yc8q62z8	43	39	at	at	IN
cord-295559-yc8q62z8	43	40	about	about	RB
cord-295559-yc8q62z8	43	41	100	100	CD
cord-295559-yc8q62z8	43	42	kDa	kDa	NNS
cord-295559-yc8q62z8	43	43	.	.	.
cord-295559-yc8q62z8	44	1	This	this	DT
cord-295559-yc8q62z8	44	2	important	important	JJ
cord-295559-yc8q62z8	44	3	difference	difference	NN
cord-295559-yc8q62z8	44	4	in	in	IN
cord-295559-yc8q62z8	44	5	the	the	DT
cord-295559-yc8q62z8	44	6	MERS	MERS	NNP
cord-295559-yc8q62z8	44	7	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	44	8	is	be	VBZ
cord-295559-yc8q62z8	44	9	likely	likely	JJ
cord-295559-yc8q62z8	44	10	due	due	JJ
cord-295559-yc8q62z8	44	11	to	to	IN
cord-295559-yc8q62z8	44	12	differences	difference	NNS
cord-295559-yc8q62z8	44	13	between	between	IN
cord-295559-yc8q62z8	44	14	our	-PRON-	PRP$
cord-295559-yc8q62z8	44	15	293	293	CD
cord-295559-yc8q62z8	44	16	T	T	NNP
cord-295559-yc8q62z8	44	17	cells	cell	NNS
cord-295559-yc8q62z8	44	18	and	and	CC
cord-295559-yc8q62z8	44	19	those	those	DT
cord-295559-yc8q62z8	44	20	used	use	VBN
cord-295559-yc8q62z8	44	21	in	in	IN
cord-295559-yc8q62z8	44	22	the	the	DT
cord-295559-yc8q62z8	44	23	Poehlmann	Poehlmann	NNP
cord-295559-yc8q62z8	44	24	laboratory	laboratory	NN
cord-295559-yc8q62z8	44	25	.	.	.
cord-295559-yc8q62z8	45	1	Surprisingly	surprisingly	RB
cord-295559-yc8q62z8	45	2	,	,	,
cord-295559-yc8q62z8	45	3	when	when	WRB
cord-295559-yc8q62z8	45	4	these	these	DT
cord-295559-yc8q62z8	45	5	MERS	MERS	NNP
cord-295559-yc8q62z8	45	6	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	45	7	and	and	CC
cord-295559-yc8q62z8	45	8	cell	cell	NN
cord-295559-yc8q62z8	45	9	lysates	lysate	NNS
cord-295559-yc8q62z8	45	10	were	be	VBD
cord-295559-yc8q62z8	45	11	blotted	blot	VBN
cord-295559-yc8q62z8	45	12	with	with	IN
cord-295559-yc8q62z8	45	13	polyclonal	polyclonal	JJ
cord-295559-yc8q62z8	45	14	goat	goat	NN
cord-295559-yc8q62z8	45	15	antibody	antibody	NN
cord-295559-yc8q62z8	45	16	AO4	AO4	NNP
cord-295559-yc8q62z8	45	17	to	to	IN
cord-295559-yc8q62z8	45	18	spikes	spike	NNS
cord-295559-yc8q62z8	45	19	purified	purify	VBN
cord-295559-yc8q62z8	45	20	from	from	IN
cord-295559-yc8q62z8	45	21	detergent	detergent	NN
cord-295559-yc8q62z8	45	22	-	-	HYPH
cord-295559-yc8q62z8	45	23	disrupted	disrupt	VBN
cord-295559-yc8q62z8	45	24	virions	virion	NNS
cord-295559-yc8q62z8	45	25	of	of	IN
cord-295559-yc8q62z8	45	26	MHV	MHV	NNP
cord-295559-yc8q62z8	45	27	-	-	HYPH
cord-295559-yc8q62z8	45	28	A59	A59	NNP
cord-295559-yc8q62z8	45	29	,	,	,
cord-295559-yc8q62z8	45	30	a	a	DT
cord-295559-yc8q62z8	45	31	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	45	32	in	in	IN
cord-295559-yc8q62z8	45	33	group	group	NN
cord-295559-yc8q62z8	45	34	a	a	NNP
cord-295559-yc8q62z8	45	35	,	,	,
cord-295559-yc8q62z8	45	36	the	the	DT
cord-295559-yc8q62z8	45	37	MERS	MERS	NNP
cord-295559-yc8q62z8	45	38	S	S	NNP
cord-295559-yc8q62z8	45	39	protein	protein	NN
cord-295559-yc8q62z8	45	40	bands	band	NNS
cord-295559-yc8q62z8	45	41	were	be	VBD
cord-295559-yc8q62z8	45	42	detected	detect	VBN
cord-295559-yc8q62z8	45	43	(	(	-LRB-
cord-295559-yc8q62z8	45	44	Figure	figure	NN
cord-295559-yc8q62z8	45	45	1B	1b	CD
cord-295559-yc8q62z8	45	46	)	)	-RRB-
cord-295559-yc8q62z8	45	47	.	.	.
cord-295559-yc8q62z8	46	1	Immunoblotting	immunoblotte	VBG
cord-295559-yc8q62z8	46	2	of	of	IN
cord-295559-yc8q62z8	46	3	soluble	soluble	JJ
cord-295559-yc8q62z8	46	4	,	,	,
cord-295559-yc8q62z8	46	5	truncated	truncated	JJ
cord-295559-yc8q62z8	46	6	MERS	MERS	NNP
cord-295559-yc8q62z8	46	7	S	S	NNP
cord-295559-yc8q62z8	46	8	proteins	protein	NNS
cord-295559-yc8q62z8	46	9	with	with	IN
cord-295559-yc8q62z8	46	10	C	c	NN
cord-295559-yc8q62z8	46	11	-	-	HYPH
cord-295559-yc8q62z8	46	12	terminal	terminal	NN
cord-295559-yc8q62z8	46	13	FLAG	flag	NN
cord-295559-yc8q62z8	46	14	tags	tag	NNS
cord-295559-yc8q62z8	46	15	showed	show	VBD
cord-295559-yc8q62z8	46	16	that	that	IN
cord-295559-yc8q62z8	46	17	the	the	DT
cord-295559-yc8q62z8	46	18	AO4	AO4	NNP
cord-295559-yc8q62z8	46	19	antibody	antibody	NN
cord-295559-yc8q62z8	46	20	did	do	VBD
cord-295559-yc8q62z8	46	21	not	not	RB
cord-295559-yc8q62z8	46	22	recognize	recognize	VB
cord-295559-yc8q62z8	46	23	the	the	DT
cord-295559-yc8q62z8	46	24	S1	s1	NN
cord-295559-yc8q62z8	46	25	domain	domain	NN
cord-295559-yc8q62z8	46	26	of	of	IN
cord-295559-yc8q62z8	46	27	MERS	MERS	NNP
cord-295559-yc8q62z8	46	28	S	S	NNP
cord-295559-yc8q62z8	46	29	(	(	-LRB-
cord-295559-yc8q62z8	46	30	Figure	Figure	NNP
cord-295559-yc8q62z8	46	31	1C	1c	NN
cord-295559-yc8q62z8	46	32	)	)	-RRB-
cord-295559-yc8q62z8	46	33	,	,	,
cord-295559-yc8q62z8	46	34	so	so	CC
cord-295559-yc8q62z8	46	35	the	the	DT
cord-295559-yc8q62z8	46	36	cross	cross	NN
cord-295559-yc8q62z8	46	37	-	-	NN
cord-295559-yc8q62z8	46	38	reactivity	reactivity	NN
cord-295559-yc8q62z8	46	39	between	between	IN
cord-295559-yc8q62z8	46	40	these	these	DT
cord-295559-yc8q62z8	46	41	proteins	protein	NNS
cord-295559-yc8q62z8	46	42	from	from	IN
cord-295559-yc8q62z8	46	43	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	46	44	groups	group	NNS
cord-295559-yc8q62z8	46	45	a	a	NNP
cord-295559-yc8q62z8	46	46	and	and	CC
cord-295559-yc8q62z8	46	47	c	c	NN
cord-295559-yc8q62z8	46	48	must	must	MD
cord-295559-yc8q62z8	46	49	lie	lie	VB
cord-295559-yc8q62z8	46	50	within	within	IN
cord-295559-yc8q62z8	46	51	the	the	DT
cord-295559-yc8q62z8	46	52	S2	S2	NNP
cord-295559-yc8q62z8	46	53	domain	domain	NN
cord-295559-yc8q62z8	46	54	.	.	.
cord-295559-yc8q62z8	47	1	Vero	Vero	NNP
cord-295559-yc8q62z8	47	2	E6	E6	NNP
cord-295559-yc8q62z8	47	3	and	and	CC
cord-295559-yc8q62z8	47	4	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	47	5	monkey	monkey	NN
cord-295559-yc8q62z8	47	6	kidney	kidney	NN
cord-295559-yc8q62z8	47	7	cell	cell	NN
cord-295559-yc8q62z8	47	8	lines	line	NNS
cord-295559-yc8q62z8	47	9	are	be	VBP
cord-295559-yc8q62z8	47	10	susceptible	susceptible	JJ
cord-295559-yc8q62z8	47	11	to	to	IN
cord-295559-yc8q62z8	47	12	infection	infection	NN
cord-295559-yc8q62z8	47	13	with	with	IN
cord-295559-yc8q62z8	47	14	MERS	MERS	NNP
cord-295559-yc8q62z8	47	15	-	-	HYPH
cord-295559-yc8q62z8	47	16	CoV	CoV	NNP
cord-295559-yc8q62z8	47	17	virus	virus	NN
cord-295559-yc8q62z8	47	18	and	and	CC
cord-295559-yc8q62z8	47	19	to	to	IN
cord-295559-yc8q62z8	47	20	SARS	SARS	NNP
cord-295559-yc8q62z8	47	21	-	-	HYPH
cord-295559-yc8q62z8	47	22	CoV	CoV	NNP
cord-295559-yc8q62z8	47	23	[	[	-LRB-
cord-295559-yc8q62z8	47	24	10	10	CD
cord-295559-yc8q62z8	47	25	,	,	,
cord-295559-yc8q62z8	47	26	34	34	CD
cord-295559-yc8q62z8	47	27	]	]	-RRB-
cord-295559-yc8q62z8	47	28	,	,	,
cord-295559-yc8q62z8	47	29	and	and	CC
cord-295559-yc8q62z8	47	30	also	also	RB
cord-295559-yc8q62z8	47	31	susceptible	susceptible	JJ
cord-295559-yc8q62z8	47	32	to	to	IN
cord-295559-yc8q62z8	47	33	SARS	SARS	NNP
cord-295559-yc8q62z8	47	34	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	47	35	and	and	CC
cord-295559-yc8q62z8	47	36	to	to	IN
cord-295559-yc8q62z8	47	37	MERS	MERS	NNP
cord-295559-yc8q62z8	47	38	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	47	39	with	with	IN
cord-295559-yc8q62z8	47	40	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	47	41	S	S	NNP
cord-295559-yc8q62z8	47	42	protein	protein	NN
cord-295559-yc8q62z8	47	43	(	(	-LRB-
cord-295559-yc8q62z8	47	44	Figure	figure	NN
cord-295559-yc8q62z8	47	45	2A	2a	CD
cord-295559-yc8q62z8	47	46	)	)	-RRB-
cord-295559-yc8q62z8	47	47	.	.	.
cord-295559-yc8q62z8	48	1	Cell	cell	NN
cord-295559-yc8q62z8	48	2	entry	entry	NN
cord-295559-yc8q62z8	48	3	was	be	VBD
cord-295559-yc8q62z8	48	4	quantitated	quantitate	VBN
cord-295559-yc8q62z8	48	5	by	by	IN
cord-295559-yc8q62z8	48	6	expression	expression	NN
cord-295559-yc8q62z8	48	7	of	of	IN
cord-295559-yc8q62z8	48	8	the	the	DT
cord-295559-yc8q62z8	48	9	luciferase	luciferase	NN
cord-295559-yc8q62z8	48	10	reporter	reporter	NN
cord-295559-yc8q62z8	48	11	gene	gene	NN
cord-295559-yc8q62z8	48	12	in	in	IN
cord-295559-yc8q62z8	48	13	pseudovirus	pseudovirus	NNP
cord-295559-yc8q62z8	48	14	-	-	HYPH
cord-295559-yc8q62z8	48	15	transduced	transduce	VBN
cord-295559-yc8q62z8	48	16	cells	cell	NNS
cord-295559-yc8q62z8	48	17	.	.	.
cord-295559-yc8q62z8	49	1	Compared	compare	VBN
cord-295559-yc8q62z8	49	2	to	to	TO
cord-295559-yc8q62z8	49	3	control	control	VB
cord-295559-yc8q62z8	49	4	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	49	5	with	with	IN
cord-295559-yc8q62z8	49	6	no	no	DT
cord-295559-yc8q62z8	49	7	spike	spike	NN
cord-295559-yc8q62z8	49	8	protein	protein	NN
cord-295559-yc8q62z8	49	9	,	,	,
cord-295559-yc8q62z8	49	10	MERS	MERS	NNP
cord-295559-yc8q62z8	49	11	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	49	12	showed	show	VBD
cord-295559-yc8q62z8	49	13	a	a	DT
cord-295559-yc8q62z8	49	14	100	100	CD
cord-295559-yc8q62z8	49	15	to	to	TO
cord-295559-yc8q62z8	49	16	1,000	1,000	CD
cord-295559-yc8q62z8	49	17	fold	fold	VB
cord-295559-yc8q62z8	49	18	increase	increase	NN
cord-295559-yc8q62z8	49	19	in	in	IN
cord-295559-yc8q62z8	49	20	luciferase	luciferase	JJ
cord-295559-yc8q62z8	49	21	activity	activity	NN
cord-295559-yc8q62z8	49	22	in	in	IN
cord-295559-yc8q62z8	49	23	Vero	Vero	NNP
cord-295559-yc8q62z8	49	24	E6	E6	NNP
cord-295559-yc8q62z8	49	25	and	and	CC
cord-295559-yc8q62z8	49	26	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	49	27	cells	cell	NNS
cord-295559-yc8q62z8	49	28	(	(	-LRB-
cord-295559-yc8q62z8	49	29	Figure	figure	NN
cord-295559-yc8q62z8	49	30	2A	2a	NN
cord-295559-yc8q62z8	49	31	and	and	CC
cord-295559-yc8q62z8	49	32	B	b	NN
cord-295559-yc8q62z8	49	33	)	)	-RRB-
cord-295559-yc8q62z8	49	34	,	,	,
cord-295559-yc8q62z8	49	35	and	and	CC
cord-295559-yc8q62z8	49	36	SARS	SARS	NNP
cord-295559-yc8q62z8	49	37	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	49	38	showed	show	VBD
cord-295559-yc8q62z8	49	39	a	a	DT
cord-295559-yc8q62z8	49	40	1,000	1,000	CD
cord-295559-yc8q62z8	49	41	increase	increase	NN
cord-295559-yc8q62z8	49	42	in	in	IN
cord-295559-yc8q62z8	49	43	luciferase	luciferase	JJ
cord-295559-yc8q62z8	49	44	activity	activity	NN
cord-295559-yc8q62z8	49	45	in	in	IN
cord-295559-yc8q62z8	49	46	Vero	Vero	NNP
cord-295559-yc8q62z8	49	47	E6	E6	NNP
cord-295559-yc8q62z8	49	48	cells	cell	NNS
cord-295559-yc8q62z8	49	49	.	.	.
cord-295559-yc8q62z8	50	1	Because	because	IN
cord-295559-yc8q62z8	50	2	the	the	DT
cord-295559-yc8q62z8	50	3	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	50	4	MERS	MERS	NNP
cord-295559-yc8q62z8	50	5	-	-	HYPH
cord-295559-yc8q62z8	50	6	CoV	CoV	NNP
cord-295559-yc8q62z8	50	7	S	S	NNP
cord-295559-yc8q62z8	50	8	protein	protein	NN
cord-295559-yc8q62z8	50	9	mediated	mediate	VBD
cord-295559-yc8q62z8	50	10	virus	virus	NN
cord-295559-yc8q62z8	50	11	entry	entry	NN
cord-295559-yc8q62z8	50	12	into	into	IN
cord-295559-yc8q62z8	50	13	Vero	Vero	NNP
cord-295559-yc8q62z8	50	14	E6	E6	NNP
cord-295559-yc8q62z8	50	15	and	and	CC
cord-295559-yc8q62z8	50	16	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	50	17	cells	cell	NNS
cord-295559-yc8q62z8	50	18	,	,	,
cord-295559-yc8q62z8	50	19	transduction	transduction	NN
cord-295559-yc8q62z8	50	20	by	by	IN
cord-295559-yc8q62z8	50	21	MERS	MERS	NNP
cord-295559-yc8q62z8	50	22	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	50	23	was	be	VBD
cord-295559-yc8q62z8	50	24	used	use	VBN
cord-295559-yc8q62z8	50	25	to	to	TO
cord-295559-yc8q62z8	50	26	identify	identify	VB
cord-295559-yc8q62z8	50	27	additional	additional	JJ
cord-295559-yc8q62z8	50	28	cell	cell	NN
cord-295559-yc8q62z8	50	29	lines	line	NNS
cord-295559-yc8q62z8	50	30	that	that	WDT
cord-295559-yc8q62z8	50	31	express	express	VBP
cord-295559-yc8q62z8	50	32	functional	functional	JJ
cord-295559-yc8q62z8	50	33	receptors	receptor	NNS
cord-295559-yc8q62z8	50	34	for	for	IN
cord-295559-yc8q62z8	50	35	MERS	MERS	NNP
cord-295559-yc8q62z8	50	36	-	-	HYPH
cord-295559-yc8q62z8	50	37	CoV	CoV	NNP
cord-295559-yc8q62z8	50	38	[	[	-LRB-
cord-295559-yc8q62z8	50	39	10	10	CD
cord-295559-yc8q62z8	50	40	,	,	,
cord-295559-yc8q62z8	50	41	34	34	CD
cord-295559-yc8q62z8	50	42	]	]	-RRB-
cord-295559-yc8q62z8	50	43	.	.	.
cord-295559-yc8q62z8	51	1	MERS	MERS	NNP
cord-295559-yc8q62z8	51	2	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	51	3	detected	detect	VBD
cord-295559-yc8q62z8	51	4	strong	strong	JJ
cord-295559-yc8q62z8	51	5	MERS	MERS	NNP
cord-295559-yc8q62z8	51	6	-	-	HYPH
cord-295559-yc8q62z8	51	7	CoV	cov	NN
cord-295559-yc8q62z8	51	8	receptor	receptor	NN
cord-295559-yc8q62z8	51	9	activity	activity	NN
cord-295559-yc8q62z8	51	10	on	on	IN
cord-295559-yc8q62z8	51	11	the	the	DT
cord-295559-yc8q62z8	51	12	Calu3	Calu3	NNP
cord-295559-yc8q62z8	51	13	line	line	NN
cord-295559-yc8q62z8	51	14	of	of	IN
cord-295559-yc8q62z8	51	15	human	human	JJ
cord-295559-yc8q62z8	51	16	airway	airway	NN
cord-295559-yc8q62z8	51	17	epithelial	epithelial	JJ
cord-295559-yc8q62z8	51	18	cells	cell	NNS
cord-295559-yc8q62z8	51	19	(	(	-LRB-
cord-295559-yc8q62z8	51	20	Figure	figure	NN
cord-295559-yc8q62z8	51	21	2A	2a	NN
cord-295559-yc8q62z8	51	22	and	and	CC
cord-295559-yc8q62z8	51	23	B	b	NN
cord-295559-yc8q62z8	51	24	)	)	-RRB-
cord-295559-yc8q62z8	51	25	,	,	,
cord-295559-yc8q62z8	51	26	and	and	CC
cord-295559-yc8q62z8	51	27	weaker	weak	JJR
cord-295559-yc8q62z8	51	28	receptor	receptor	NN
cord-295559-yc8q62z8	51	29	activity	activity	NN
cord-295559-yc8q62z8	51	30	on	on	IN
cord-295559-yc8q62z8	51	31	the	the	DT
cord-295559-yc8q62z8	51	32	A549	a549	JJ
cord-295559-yc8q62z8	51	33	line	line	NN
cord-295559-yc8q62z8	51	34	of	of	IN
cord-295559-yc8q62z8	51	35	human	human	JJ
cord-295559-yc8q62z8	51	36	alveolar	alveolar	NN
cord-295559-yc8q62z8	51	37	basal	basal	NN
cord-295559-yc8q62z8	51	38	epithelial	epithelial	JJ
cord-295559-yc8q62z8	51	39	cells	cell	NNS
cord-295559-yc8q62z8	51	40	(	(	-LRB-
cord-295559-yc8q62z8	52	1	Figure	figure	NN
cord-295559-yc8q62z8	52	2	 	 	_SP
cord-295559-yc8q62z8	52	3	2A	2a	CD
cord-295559-yc8q62z8	52	4	)	)	-RRB-
cord-295559-yc8q62z8	52	5	as	as	IN
cord-295559-yc8q62z8	52	6	also	also	RB
cord-295559-yc8q62z8	52	7	shown	show	VBN
cord-295559-yc8q62z8	52	8	by	by	IN
cord-295559-yc8q62z8	52	9	MERS	MERS	NNP
cord-295559-yc8q62z8	52	10	-	-	HYPH
cord-295559-yc8q62z8	52	11	CoV	CoV	NNP
cord-295559-yc8q62z8	52	12	infection	infection	NN
cord-295559-yc8q62z8	52	13	[	[	-LRB-
cord-295559-yc8q62z8	52	14	35	35	CD
cord-295559-yc8q62z8	52	15	]	]	-RRB-
cord-295559-yc8q62z8	52	16	.	.	.
cord-295559-yc8q62z8	53	1	Interestingly	interestingly	RB
cord-295559-yc8q62z8	53	2	,	,	,
cord-295559-yc8q62z8	53	3	the	the	DT
cord-295559-yc8q62z8	53	4	EFF	EFF	NNP
cord-295559-yc8q62z8	53	5	embryo	embryo	NN
cord-295559-yc8q62z8	53	6	cell	cell	NN
cord-295559-yc8q62z8	53	7	line	line	NN
cord-295559-yc8q62z8	53	8	from	from	IN
cord-295559-yc8q62z8	53	9	Eptesicus	Eptesicus	NNP
cord-295559-yc8q62z8	53	10	fuscus	fuscus	NN
cord-295559-yc8q62z8	53	11	bats	bat	NNS
cord-295559-yc8q62z8	53	12	was	be	VBD
cord-295559-yc8q62z8	53	13	susceptible	susceptible	JJ
cord-295559-yc8q62z8	53	14	to	to	IN
cord-295559-yc8q62z8	53	15	MERS	MERS	NNP
cord-295559-yc8q62z8	53	16	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	53	17	,	,	,
cord-295559-yc8q62z8	53	18	increasing	increase	VBG
cord-295559-yc8q62z8	53	19	luciferase	luciferase	NN
cord-295559-yc8q62z8	53	20	activity	activity	NN
cord-295559-yc8q62z8	53	21	by	by	IN
cord-295559-yc8q62z8	53	22	nearly	nearly	RB
cord-295559-yc8q62z8	53	23	100-fold	100-fold	CD
cord-295559-yc8q62z8	53	24	compared	compare	VBN
cord-295559-yc8q62z8	53	25	to	to	IN
cord-295559-yc8q62z8	53	26	the	the	DT
cord-295559-yc8q62z8	53	27	no	no	DT
cord-295559-yc8q62z8	53	28	spike	spike	NN
cord-295559-yc8q62z8	53	29	control	control	NN
cord-295559-yc8q62z8	53	30	,	,	,
cord-295559-yc8q62z8	53	31	but	but	CC
cord-295559-yc8q62z8	53	32	the	the	DT
cord-295559-yc8q62z8	53	33	TB1Lu	TB1Lu	NNP
cord-295559-yc8q62z8	53	34	lung	lung	NN
cord-295559-yc8q62z8	53	35	cell	cell	NN
cord-295559-yc8q62z8	53	36	line	line	NN
cord-295559-yc8q62z8	53	37	from	from	IN
cord-295559-yc8q62z8	53	38	Tadarida	Tadarida	NNP
cord-295559-yc8q62z8	53	39	brasiliensis	brasiliensis	NN
cord-295559-yc8q62z8	53	40	bats	bat	NNS
cord-295559-yc8q62z8	53	41	,	,	,
cord-295559-yc8q62z8	53	42	murine	murine	JJ
cord-295559-yc8q62z8	53	43	fibroblasts	fibroblast	NNS
cord-295559-yc8q62z8	53	44	and	and	CC
cord-295559-yc8q62z8	53	45	HeLa	HeLa	NNP
cord-295559-yc8q62z8	53	46	cells	cell	NNS
cord-295559-yc8q62z8	53	47	were	be	VBD
cord-295559-yc8q62z8	53	48	not	not	RB
cord-295559-yc8q62z8	53	49	susceptible	susceptible	JJ
cord-295559-yc8q62z8	53	50	to	to	IN
cord-295559-yc8q62z8	53	51	MERS	MERS	NNP
cord-295559-yc8q62z8	53	52	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	53	53	(	(	-LRB-
cord-295559-yc8q62z8	53	54	Figure	Figure	NNP
cord-295559-yc8q62z8	53	55	2C	2c	NN
cord-295559-yc8q62z8	53	56	)	)	-RRB-
cord-295559-yc8q62z8	53	57	.	.	.
cord-295559-yc8q62z8	54	1	Expression	expression	NN
cord-295559-yc8q62z8	54	2	of	of	IN
cord-295559-yc8q62z8	54	3	human	human	JJ
cord-295559-yc8q62z8	54	4	ACE2	ACE2	NNP
cord-295559-yc8q62z8	54	5	in	in	IN
cord-295559-yc8q62z8	54	6	293	293	CD
cord-295559-yc8q62z8	54	7	T	t	NN
cord-295559-yc8q62z8	54	8	cells	cell	NNS
cord-295559-yc8q62z8	54	9	did	do	VBD
cord-295559-yc8q62z8	54	10	not	not	RB
cord-295559-yc8q62z8	54	11	significantly	significantly	RB
cord-295559-yc8q62z8	54	12	increase	increase	VB
cord-295559-yc8q62z8	54	13	susceptibility	susceptibility	NN
cord-295559-yc8q62z8	54	14	to	to	IN
cord-295559-yc8q62z8	54	15	MERS	MERS	NNP
cord-295559-yc8q62z8	54	16	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	54	17	(	(	-LRB-
cord-295559-yc8q62z8	54	18	Figure	Figure	NNP
cord-295559-yc8q62z8	54	19	3A	3a	CD
cord-295559-yc8q62z8	54	20	)	)	-RRB-
cord-295559-yc8q62z8	54	21	,	,	,
cord-295559-yc8q62z8	54	22	although	although	IN
cord-295559-yc8q62z8	54	23	as	as	IN
cord-295559-yc8q62z8	54	24	expected	expect	VBN
cord-295559-yc8q62z8	54	25	hACE2	hace2	NN
cord-295559-yc8q62z8	54	26	greatly	greatly	RB
cord-295559-yc8q62z8	54	27	increased	increase	VBN
cord-295559-yc8q62z8	54	28	susceptibility	susceptibility	NN
cord-295559-yc8q62z8	54	29	of	of	IN
cord-295559-yc8q62z8	54	30	293	293	CD
cord-295559-yc8q62z8	54	31	T	t	NN
cord-295559-yc8q62z8	54	32	cells	cell	NNS
cord-295559-yc8q62z8	54	33	to	to	IN
cord-295559-yc8q62z8	54	34	SARS	SARS	NNP
cord-295559-yc8q62z8	54	35	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	54	36	(	(	-LRB-
cord-295559-yc8q62z8	54	37	Figure	Figure	NNP
cord-295559-yc8q62z8	54	38	3A	3a	CD
cord-295559-yc8q62z8	54	39	)	)	-RRB-
cord-295559-yc8q62z8	54	40	.	.	.
cord-295559-yc8q62z8	55	1	Figure	figure	NN
cord-295559-yc8q62z8	55	2	3B	3b	NN
cord-295559-yc8q62z8	55	3	and	and	CC
cord-295559-yc8q62z8	55	4	C	C	NNP
cord-295559-yc8q62z8	55	5	show	show	VBP
cord-295559-yc8q62z8	55	6	that	that	IN
cord-295559-yc8q62z8	55	7	neither	neither	CC
cord-295559-yc8q62z8	55	8	human	human	JJ
cord-295559-yc8q62z8	55	9	CEACAM1	CEACAM1	NNP
cord-295559-yc8q62z8	55	10	,	,	,
cord-295559-yc8q62z8	55	11	or	or	CC
cord-295559-yc8q62z8	55	12	four	four	CD
cord-295559-yc8q62z8	55	13	related	related	JJ
cord-295559-yc8q62z8	55	14	human	human	JJ
cord-295559-yc8q62z8	55	15	CEACAM	CEACAM	NNP
cord-295559-yc8q62z8	55	16	proteins	protein	NNS
cord-295559-yc8q62z8	55	17	or	or	CC
cord-295559-yc8q62z8	55	18	human	human	JJ
cord-295559-yc8q62z8	55	19	APN	APN	NNP
cord-295559-yc8q62z8	55	20	functions	function	NNS
cord-295559-yc8q62z8	55	21	as	as	IN
cord-295559-yc8q62z8	55	22	a	a	DT
cord-295559-yc8q62z8	55	23	receptor	receptor	NN
cord-295559-yc8q62z8	55	24	for	for	IN
cord-295559-yc8q62z8	55	25	MERS	MERS	NNP
cord-295559-yc8q62z8	55	26	-	-	HYPH
cord-295559-yc8q62z8	55	27	CoV	CoV	NNP
cord-295559-yc8q62z8	55	28	spike	spike	NN
cord-295559-yc8q62z8	55	29	protein	protein	NN
cord-295559-yc8q62z8	55	30	.	.	.
cord-295559-yc8q62z8	56	1	These	these	DT
cord-295559-yc8q62z8	56	2	experiments	experiment	NNS
cord-295559-yc8q62z8	56	3	confirm	confirm	VBP
cord-295559-yc8q62z8	56	4	the	the	DT
cord-295559-yc8q62z8	56	5	observation	observation	NN
cord-295559-yc8q62z8	56	6	that	that	IN
cord-295559-yc8q62z8	56	7	MERS	MERS	NNP
cord-295559-yc8q62z8	56	8	-	-	HYPH
cord-295559-yc8q62z8	56	9	CoV	CoV	NNP
cord-295559-yc8q62z8	56	10	does	do	VBZ
cord-295559-yc8q62z8	56	11	not	not	RB
cord-295559-yc8q62z8	56	12	use	use	VB
cord-295559-yc8q62z8	56	13	the	the	DT
cord-295559-yc8q62z8	56	14	receptor	receptor	NN
cord-295559-yc8q62z8	56	15	proteins	protein	NNS
cord-295559-yc8q62z8	56	16	known	know	VBN
cord-295559-yc8q62z8	56	17	for	for	IN
cord-295559-yc8q62z8	56	18	other	other	JJ
cord-295559-yc8q62z8	56	19	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	56	20	[	[	-LRB-
cord-295559-yc8q62z8	56	21	33	33	CD
cord-295559-yc8q62z8	56	22	]	]	-RRB-
cord-295559-yc8q62z8	56	23	or	or	CC
cord-295559-yc8q62z8	56	24	related	relate	VBN
cord-295559-yc8q62z8	56	25	human	human	JJ
cord-295559-yc8q62z8	56	26	membrane	membrane	NN
cord-295559-yc8q62z8	56	27	proteins	protein	NNS
cord-295559-yc8q62z8	56	28	.	.	.
cord-295559-yc8q62z8	57	1	Instead	instead	RB
cord-295559-yc8q62z8	57	2	DPP4	DPP4	NNP
cord-295559-yc8q62z8	57	3	is	be	VBZ
cord-295559-yc8q62z8	57	4	the	the	DT
cord-295559-yc8q62z8	57	5	principal	principal	JJ
cord-295559-yc8q62z8	57	6	receptor	receptor	NN
cord-295559-yc8q62z8	57	7	protein	protein	NN
cord-295559-yc8q62z8	57	8	for	for	IN
cord-295559-yc8q62z8	57	9	MERS	MERS	NNP
cord-295559-yc8q62z8	57	10	-	-	HYPH
cord-295559-yc8q62z8	57	11	CoV	CoV	NNP
cord-295559-yc8q62z8	57	12	[	[	-LRB-
cord-295559-yc8q62z8	57	13	28	28	CD
cord-295559-yc8q62z8	57	14	]	]	-RRB-
cord-295559-yc8q62z8	57	15	.	.	.
cord-295559-yc8q62z8	58	1	MERS	MERS	NNP
cord-295559-yc8q62z8	58	2	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	58	3	induced	induce	VBD
cord-295559-yc8q62z8	58	4	a	a	DT
cord-295559-yc8q62z8	58	5	small	small	JJ
cord-295559-yc8q62z8	58	6	but	but	CC
cord-295559-yc8q62z8	58	7	consistent	consistent	JJ
cord-295559-yc8q62z8	58	8	5	5	CD
cord-295559-yc8q62z8	58	9	to	to	IN
cord-295559-yc8q62z8	58	10	10-fold	10-fold	JJ
cord-295559-yc8q62z8	58	11	increase	increase	NN
cord-295559-yc8q62z8	58	12	in	in	IN
cord-295559-yc8q62z8	58	13	luciferase	luciferase	JJ
cord-295559-yc8q62z8	58	14	activity	activity	NN
cord-295559-yc8q62z8	58	15	in	in	IN
cord-295559-yc8q62z8	58	16	293	293	CD
cord-295559-yc8q62z8	58	17	T	T	NNP
cord-295559-yc8q62z8	58	18	human	human	JJ
cord-295559-yc8q62z8	58	19	embryo	embryo	NN
cord-295559-yc8q62z8	58	20	kidney	kidney	NN
cord-295559-yc8q62z8	58	21	cells	cell	NNS
cord-295559-yc8q62z8	58	22	compared	compare	VBN
cord-295559-yc8q62z8	58	23	to	to	IN
cord-295559-yc8q62z8	58	24	the	the	DT
cord-295559-yc8q62z8	58	25	no	no	DT
cord-295559-yc8q62z8	58	26	spike	spike	NN
cord-295559-yc8q62z8	58	27	control	control	NN
cord-295559-yc8q62z8	58	28	virus	virus	NN
cord-295559-yc8q62z8	58	29	(	(	-LRB-
cord-295559-yc8q62z8	58	30	Figure	figure	NN
cord-295559-yc8q62z8	58	31	2C	2c	NN
cord-295559-yc8q62z8	58	32	)	)	-RRB-
cord-295559-yc8q62z8	58	33	,	,	,
cord-295559-yc8q62z8	58	34	suggesting	suggest	VBG
cord-295559-yc8q62z8	58	35	that	that	IN
cord-295559-yc8q62z8	58	36	our	-PRON-	PRP$
cord-295559-yc8q62z8	58	37	293	293	CD
cord-295559-yc8q62z8	58	38	T	T	NNP
cord-295559-yc8q62z8	58	39	cells	cell	NNS
cord-295559-yc8q62z8	58	40	expressed	express	VBD
cord-295559-yc8q62z8	58	41	either	either	CC
cord-295559-yc8q62z8	58	42	a	a	DT
cord-295559-yc8q62z8	58	43	low	low	JJ
cord-295559-yc8q62z8	58	44	level	level	NN
cord-295559-yc8q62z8	58	45	of	of	IN
cord-295559-yc8q62z8	58	46	DPP4	DPP4	NNP
cord-295559-yc8q62z8	58	47	,	,	,
cord-295559-yc8q62z8	58	48	or	or	CC
cord-295559-yc8q62z8	58	49	an	an	DT
cord-295559-yc8q62z8	58	50	alternative	alternative	NN
cord-295559-yc8q62z8	58	51	but	but	CC
cord-295559-yc8q62z8	58	52	less	less	RBR
cord-295559-yc8q62z8	58	53	efficient	efficient	JJ
cord-295559-yc8q62z8	58	54	receptor	receptor	NN
cord-295559-yc8q62z8	58	55	,	,	,
cord-295559-yc8q62z8	58	56	such	such	JJ
cord-295559-yc8q62z8	58	57	as	as	IN
cord-295559-yc8q62z8	58	58	CD209L	CD209L	NNP
cord-295559-yc8q62z8	58	59	or	or	CC
cord-295559-yc8q62z8	58	60	LSECtin	lsectin	NN
cord-295559-yc8q62z8	58	61	for	for	IN
cord-295559-yc8q62z8	58	62	SARS	SARS	NNP
cord-295559-yc8q62z8	58	63	-	-	HYPH
cord-295559-yc8q62z8	58	64	CoV	CoV	NNP
cord-295559-yc8q62z8	58	65	[	[	-LRB-
cord-295559-yc8q62z8	58	66	36	36	CD
cord-295559-yc8q62z8	58	67	,	,	,
cord-295559-yc8q62z8	58	68	37	37	CD
cord-295559-yc8q62z8	58	69	]	]	-RRB-
cord-295559-yc8q62z8	58	70	.	.	.
cord-295559-yc8q62z8	59	1	To	to	TO
cord-295559-yc8q62z8	59	2	determine	determine	VB
cord-295559-yc8q62z8	59	3	whether	whether	IN
cord-295559-yc8q62z8	59	4	entry	entry	NN
cord-295559-yc8q62z8	59	5	of	of	IN
cord-295559-yc8q62z8	59	6	MERS	MERS	NNP
cord-295559-yc8q62z8	59	7	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	59	8	with	with	IN
cord-295559-yc8q62z8	59	9	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	59	10	S	S	NNP
cord-295559-yc8q62z8	59	11	protein	protein	NN
cord-295559-yc8q62z8	59	12	required	require	VBD
cord-295559-yc8q62z8	59	13	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	59	14	and	and	CC
cord-295559-yc8q62z8	59	15	acidification	acidification	NN
cord-295559-yc8q62z8	59	16	in	in	IN
cord-295559-yc8q62z8	59	17	endosomes	endosome	NNS
cord-295559-yc8q62z8	59	18	,	,	,
cord-295559-yc8q62z8	59	19	the	the	DT
cord-295559-yc8q62z8	59	20	effects	effect	NNS
cord-295559-yc8q62z8	59	21	of	of	IN
cord-295559-yc8q62z8	59	22	ammonium	ammonium	NN
cord-295559-yc8q62z8	59	23	chloride	chloride	NN
cord-295559-yc8q62z8	59	24	and	and	CC
cord-295559-yc8q62z8	59	25	bafilomycin	bafilomycin	VBZ
cord-295559-yc8q62z8	59	26	A	A	NNP
cord-295559-yc8q62z8	59	27	,	,	,
cord-295559-yc8q62z8	59	28	lysosomotropic	lysosomotropic	JJ
cord-295559-yc8q62z8	59	29	agents	agent	NNS
cord-295559-yc8q62z8	59	30	that	that	WDT
cord-295559-yc8q62z8	59	31	inhibit	inhibit	VBP
cord-295559-yc8q62z8	59	32	the	the	DT
cord-295559-yc8q62z8	59	33	acidification	acidification	NN
cord-295559-yc8q62z8	59	34	of	of	IN
cord-295559-yc8q62z8	59	35	endosomes	endosome	NNS
cord-295559-yc8q62z8	59	36	,	,	,
cord-295559-yc8q62z8	59	37	were	be	VBD
cord-295559-yc8q62z8	59	38	studied	study	VBN
cord-295559-yc8q62z8	59	39	.	.	.
cord-295559-yc8q62z8	60	1	In	in	IN
cord-295559-yc8q62z8	60	2	Vero	Vero	NNP
cord-295559-yc8q62z8	60	3	E6	E6	NNP
cord-295559-yc8q62z8	60	4	cells	cell	NNS
cord-295559-yc8q62z8	60	5	,	,	,
cord-295559-yc8q62z8	60	6	20mM	20mm	CD
cord-295559-yc8q62z8	60	7	NH	NH	NNP
cord-295559-yc8q62z8	60	8	4	4	CD
cord-295559-yc8q62z8	60	9	Cl	Cl	NNP
cord-295559-yc8q62z8	60	10	inhibited	inhibit	VBN
cord-295559-yc8q62z8	60	11	entry	entry	NN
cord-295559-yc8q62z8	60	12	of	of	IN
cord-295559-yc8q62z8	60	13	SARS	SARS	NNP
cord-295559-yc8q62z8	60	14	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	60	15	by	by	IN
cord-295559-yc8q62z8	60	16	about	about	RB
cord-295559-yc8q62z8	60	17	99.9	99.9	CD
cord-295559-yc8q62z8	60	18	%	%	NN
cord-295559-yc8q62z8	60	19	compared	compare	VBN
cord-295559-yc8q62z8	60	20	to	to	IN
cord-295559-yc8q62z8	60	21	entry	entry	NN
cord-295559-yc8q62z8	60	22	of	of	IN
cord-295559-yc8q62z8	60	23	SARS	SARS	NNP
cord-295559-yc8q62z8	60	24	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	60	25	without	without	IN
cord-295559-yc8q62z8	60	26	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	60	27	,	,	,
cord-295559-yc8q62z8	60	28	and	and	CC
cord-295559-yc8q62z8	60	29	NH	NH	NNP
cord-295559-yc8q62z8	60	30	4	4	CD
cord-295559-yc8q62z8	60	31	Cl	Cl	NNP
cord-295559-yc8q62z8	60	32	also	also	RB
cord-295559-yc8q62z8	60	33	inhibited	inhibit	VBD
cord-295559-yc8q62z8	60	34	entry	entry	NN
cord-295559-yc8q62z8	60	35	of	of	IN
cord-295559-yc8q62z8	60	36	MERS	MERS	NNP
cord-295559-yc8q62z8	60	37	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	60	38	by	by	IN
cord-295559-yc8q62z8	60	39	about	about	RB
cord-295559-yc8q62z8	60	40	99.6	99.6	CD
cord-295559-yc8q62z8	60	41	%	%	NN
cord-295559-yc8q62z8	60	42	(	(	-LRB-
cord-295559-yc8q62z8	60	43	Figure	figure	NN
cord-295559-yc8q62z8	60	44	3A	3a	CD
cord-295559-yc8q62z8	60	45	)	)	-RRB-
cord-295559-yc8q62z8	60	46	.	.	.
cord-295559-yc8q62z8	61	1	Bafilomycin	Bafilomycin	NNP
cord-295559-yc8q62z8	61	2	A	A	NNP
cord-295559-yc8q62z8	61	3	specifically	specifically	RB
cord-295559-yc8q62z8	61	4	inhibits	inhibit	VBZ
cord-295559-yc8q62z8	61	5	the	the	DT
cord-295559-yc8q62z8	61	6	vacuolar	vacuolar	JJ
cord-295559-yc8q62z8	61	7	-	-	HYPH
cord-295559-yc8q62z8	61	8	type	type	NN
cord-295559-yc8q62z8	61	9	H+-ATPase	h+-atpase	NN
cord-295559-yc8q62z8	61	10	that	that	WDT
cord-295559-yc8q62z8	61	11	is	be	VBZ
cord-295559-yc8q62z8	61	12	required	require	VBN
cord-295559-yc8q62z8	61	13	for	for	IN
cord-295559-yc8q62z8	61	14	acidification	acidification	NN
cord-295559-yc8q62z8	61	15	of	of	IN
cord-295559-yc8q62z8	61	16	lysosomes	lysosome	NNS
cord-295559-yc8q62z8	61	17	.	.	.
cord-295559-yc8q62z8	62	1	Figure	figure	NN
cord-295559-yc8q62z8	62	2	3A	3a	NN
cord-295559-yc8q62z8	62	3	shows	show	VBZ
cord-295559-yc8q62z8	62	4	that	that	WDT
cord-295559-yc8q62z8	62	5	bafilomycin	bafilomycin	VBZ
cord-295559-yc8q62z8	62	6	A	a	DT
cord-295559-yc8q62z8	62	7	inhibited	inhibited	JJ
cord-295559-yc8q62z8	62	8	entry	entry	NN
cord-295559-yc8q62z8	62	9	of	of	IN
cord-295559-yc8q62z8	62	10	SARS	SARS	NNP
cord-295559-yc8q62z8	62	11	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	62	12	into	into	IN
cord-295559-yc8q62z8	62	13	Vero	Vero	NNP
cord-295559-yc8q62z8	62	14	E6	E6	NNP
cord-295559-yc8q62z8	62	15	cells	cell	NNS
cord-295559-yc8q62z8	62	16	by	by	IN
cord-295559-yc8q62z8	62	17	99.8	99.8	CD
cord-295559-yc8q62z8	62	18	%	%	NN
cord-295559-yc8q62z8	62	19	as	as	IN
cord-295559-yc8q62z8	62	20	previously	previously	RB
cord-295559-yc8q62z8	62	21	reported	report	VBN
cord-295559-yc8q62z8	62	22	[	[	-LRB-
cord-295559-yc8q62z8	62	23	21	21	CD
cord-295559-yc8q62z8	62	24	,	,	,
cord-295559-yc8q62z8	62	25	38	38	CD
cord-295559-yc8q62z8	62	26	]	]	-RRB-
cord-295559-yc8q62z8	62	27	,	,	,
cord-295559-yc8q62z8	62	28	and	and	CC
cord-295559-yc8q62z8	62	29	also	also	RB
cord-295559-yc8q62z8	62	30	inhibited	inhibit	VBN
cord-295559-yc8q62z8	62	31	entry	entry	NN
cord-295559-yc8q62z8	62	32	of	of	IN
cord-295559-yc8q62z8	62	33	MERS	MERS	NNP
cord-295559-yc8q62z8	62	34	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	62	35	by	by	IN
cord-295559-yc8q62z8	62	36	more	more	JJR
cord-295559-yc8q62z8	62	37	than	than	IN
cord-295559-yc8q62z8	62	38	99.9	99.9	CD
cord-295559-yc8q62z8	62	39	%	%	NN
cord-295559-yc8q62z8	62	40	compared	compare	VBN
cord-295559-yc8q62z8	62	41	to	to	IN
cord-295559-yc8q62z8	62	42	MERS	MERS	NNP
cord-295559-yc8q62z8	62	43	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	62	44	without	without	IN
cord-295559-yc8q62z8	62	45	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	62	46	.	.	.
cord-295559-yc8q62z8	63	1	In	in	IN
cord-295559-yc8q62z8	63	2	LLCMK2	llcmk2	JJ
cord-295559-yc8q62z8	63	3	cells	cell	NNS
cord-295559-yc8q62z8	63	4	,	,	,
cord-295559-yc8q62z8	63	5	although	although	IN
cord-295559-yc8q62z8	63	6	bafilomycin	bafilomycin	VBZ
cord-295559-yc8q62z8	63	7	A	a	DT
cord-295559-yc8q62z8	63	8	inhibited	inhibited	JJ
cord-295559-yc8q62z8	63	9	99.7	99.7	CD
cord-295559-yc8q62z8	63	10	%	%	NN
cord-295559-yc8q62z8	63	11	of	of	IN
cord-295559-yc8q62z8	63	12	MERS	MERS	NNP
cord-295559-yc8q62z8	63	13	-	-	HYPH
cord-295559-yc8q62z8	63	14	CoV	CoV	NNP
cord-295559-yc8q62z8	63	15	S	S	NNP
cord-295559-yc8q62z8	63	16	mediated	mediate	VBN
cord-295559-yc8q62z8	63	17	entry	entry	NN
cord-295559-yc8q62z8	63	18	,	,	,
cord-295559-yc8q62z8	63	19	NH	NH	NNP
cord-295559-yc8q62z8	63	20	4	4	CD
cord-295559-yc8q62z8	63	21	Cl	Cl	NNP
cord-295559-yc8q62z8	63	22	reduced	reduce	VBD
cord-295559-yc8q62z8	63	23	MERS	MERS	NNP
cord-295559-yc8q62z8	63	24	-	-	HYPH
cord-295559-yc8q62z8	63	25	CoV	CoV	NNP
cord-295559-yc8q62z8	63	26	S	S	NNP
cord-295559-yc8q62z8	63	27	-	-	HYPH
cord-295559-yc8q62z8	63	28	mediated	mediate	VBN
cord-295559-yc8q62z8	63	29	entry	entry	NN
cord-295559-yc8q62z8	63	30	only	only	RB
cord-295559-yc8q62z8	63	31	6-fold	6-fold	CD
cord-295559-yc8q62z8	63	32	(	(	-LRB-
cord-295559-yc8q62z8	63	33	data	datum	NNS
cord-295559-yc8q62z8	63	34	not	not	RB
cord-295559-yc8q62z8	63	35	shown	show	VBN
cord-295559-yc8q62z8	63	36	)	)	-RRB-
cord-295559-yc8q62z8	63	37	,	,	,
cord-295559-yc8q62z8	63	38	suggesting	suggest	VBG
cord-295559-yc8q62z8	63	39	that	that	IN
cord-295559-yc8q62z8	63	40	the	the	DT
cord-295559-yc8q62z8	63	41	inhibition	inhibition	NN
cord-295559-yc8q62z8	63	42	of	of	IN
cord-295559-yc8q62z8	63	43	endosomal	endosomal	JJ
cord-295559-yc8q62z8	63	44	acidification	acidification	NN
cord-295559-yc8q62z8	63	45	by	by	IN
cord-295559-yc8q62z8	63	46	NH	NH	NNP
cord-295559-yc8q62z8	63	47	4	4	CD
cord-295559-yc8q62z8	63	48	Cl	Cl	NNP
cord-295559-yc8q62z8	63	49	may	may	MD
cord-295559-yc8q62z8	63	50	be	be	VB
cord-295559-yc8q62z8	63	51	cell	cell	NN
cord-295559-yc8q62z8	63	52	type	type	NN
cord-295559-yc8q62z8	63	53	dependent	dependent	JJ
cord-295559-yc8q62z8	63	54	.	.	.
cord-295559-yc8q62z8	64	1	These	these	DT
cord-295559-yc8q62z8	64	2	experiments	experiment	NNS
cord-295559-yc8q62z8	64	3	show	show	VBP
cord-295559-yc8q62z8	64	4	that	that	IN
cord-295559-yc8q62z8	64	5	MERS	MERS	NNP
cord-295559-yc8q62z8	64	6	pseudovirions	pseudovirion	VBZ
cord-295559-yc8q62z8	64	7	with	with	IN
cord-295559-yc8q62z8	64	8	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	64	9	S	S	NNP
cord-295559-yc8q62z8	64	10	protein	protein	NN
cord-295559-yc8q62z8	64	11	can	can	MD
cord-295559-yc8q62z8	64	12	enter	enter	VB
cord-295559-yc8q62z8	64	13	monkey	monkey	NN
cord-295559-yc8q62z8	64	14	kidney	kidney	NN
cord-295559-yc8q62z8	64	15	cells	cell	NNS
cord-295559-yc8q62z8	64	16	only	only	RB
cord-295559-yc8q62z8	64	17	by	by	IN
cord-295559-yc8q62z8	64	18	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	64	19	.	.	.
cord-295559-yc8q62z8	65	1	Cathepsins	cathepsin	NNS
cord-295559-yc8q62z8	65	2	are	be	VBP
cord-295559-yc8q62z8	65	3	a	a	DT
cord-295559-yc8q62z8	65	4	diverse	diverse	JJ
cord-295559-yc8q62z8	65	5	group	group	NN
cord-295559-yc8q62z8	65	6	of	of	IN
cord-295559-yc8q62z8	65	7	acid	acid	NN
cord-295559-yc8q62z8	65	8	-	-	HYPH
cord-295559-yc8q62z8	65	9	activated	activate	VBN
cord-295559-yc8q62z8	65	10	cysteine	cysteine	NN
cord-295559-yc8q62z8	65	11	proteases	protease	NNS
cord-295559-yc8q62z8	65	12	located	locate	VBN
cord-295559-yc8q62z8	65	13	within	within	IN
cord-295559-yc8q62z8	65	14	endosomes	endosome	NNS
cord-295559-yc8q62z8	65	15	and	and	CC
cord-295559-yc8q62z8	65	16	lysosomes	lysosome	NNS
cord-295559-yc8q62z8	65	17	.	.	.
cord-295559-yc8q62z8	66	1	Cathepsin	Cathepsin	NNP
cord-295559-yc8q62z8	66	2	activity	activity	NN
cord-295559-yc8q62z8	66	3	is	be	VBZ
cord-295559-yc8q62z8	66	4	essential	essential	JJ
cord-295559-yc8q62z8	66	5	for	for	IN
cord-295559-yc8q62z8	66	6	infection	infection	NN
cord-295559-yc8q62z8	66	7	by	by	IN
cord-295559-yc8q62z8	66	8	several	several	JJ
cord-295559-yc8q62z8	66	9	viruses	virus	NNS
cord-295559-yc8q62z8	66	10	that	that	WDT
cord-295559-yc8q62z8	66	11	enter	enter	VBP
cord-295559-yc8q62z8	66	12	by	by	IN
cord-295559-yc8q62z8	66	13	the	the	DT
cord-295559-yc8q62z8	66	14	endosomal	endosomal	NNP
cord-295559-yc8q62z8	66	15	route	route	NN
cord-295559-yc8q62z8	66	16	,	,	,
cord-295559-yc8q62z8	66	17	including	include	VBG
cord-295559-yc8q62z8	66	18	reovirus	reovirus	NNP
cord-295559-yc8q62z8	66	19	[	[	-LRB-
cord-295559-yc8q62z8	66	20	39	39	CD
cord-295559-yc8q62z8	66	21	]	]	-RRB-
cord-295559-yc8q62z8	66	22	,	,	,
cord-295559-yc8q62z8	66	23	SARS	SARS	NNP
cord-295559-yc8q62z8	66	24	-	-	HYPH
cord-295559-yc8q62z8	66	25	CoV	CoV	NNP
cord-295559-yc8q62z8	66	26	[	[	-LRB-
cord-295559-yc8q62z8	66	27	22	22	CD
cord-295559-yc8q62z8	66	28	]	]	-RRB-
cord-295559-yc8q62z8	66	29	,	,	,
cord-295559-yc8q62z8	66	30	and	and	CC
cord-295559-yc8q62z8	66	31	Ebolavirus	Ebolavirus	NNP
cord-295559-yc8q62z8	66	32	[	[	-LRB-
cord-295559-yc8q62z8	66	33	40	40	CD
cord-295559-yc8q62z8	66	34	]	]	-RRB-
cord-295559-yc8q62z8	66	35	.	.	.
cord-295559-yc8q62z8	67	1	E64D	E64D	NNP
cord-295559-yc8q62z8	67	2	,	,	,
cord-295559-yc8q62z8	67	3	an	an	DT
cord-295559-yc8q62z8	67	4	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	67	5	of	of	IN
cord-295559-yc8q62z8	67	6	the	the	DT
cord-295559-yc8q62z8	67	7	cysteine	cysteine	NN
cord-295559-yc8q62z8	67	8	protease	protease	NN
cord-295559-yc8q62z8	67	9	activities	activity	NNS
cord-295559-yc8q62z8	67	10	of	of	IN
cord-295559-yc8q62z8	67	11	cathepsins	cathepsin	NNS
cord-295559-yc8q62z8	67	12	B	B	NNP
cord-295559-yc8q62z8	67	13	,	,	,
cord-295559-yc8q62z8	67	14	H	H	NNP
cord-295559-yc8q62z8	67	15	,	,	,
cord-295559-yc8q62z8	67	16	and	and	CC
cord-295559-yc8q62z8	67	17	L	l	NN
cord-295559-yc8q62z8	67	18	and	and	CC
cord-295559-yc8q62z8	67	19	calpain	calpain	NN
cord-295559-yc8q62z8	67	20	,	,	,
cord-295559-yc8q62z8	67	21	reduced	reduce	VBN
cord-295559-yc8q62z8	67	22	transduction	transduction	NN
cord-295559-yc8q62z8	67	23	of	of	IN
cord-295559-yc8q62z8	67	24	Vero	Vero	NNP
cord-295559-yc8q62z8	67	25	E6	E6	NNP
cord-295559-yc8q62z8	67	26	cells	cell	NNS
cord-295559-yc8q62z8	67	27	by	by	IN
cord-295559-yc8q62z8	67	28	SARS	SARS	NNP
cord-295559-yc8q62z8	67	29	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	67	30	by	by	IN
cord-295559-yc8q62z8	67	31	80	80	CD
cord-295559-yc8q62z8	67	32	%	%	NN
cord-295559-yc8q62z8	67	33	as	as	IN
cord-295559-yc8q62z8	67	34	previously	previously	RB
cord-295559-yc8q62z8	67	35	reported	report	VBN
cord-295559-yc8q62z8	67	36	(	(	-LRB-
cord-295559-yc8q62z8	67	37	Figure	figure	NN
cord-295559-yc8q62z8	67	38	3B	3b	CD
cord-295559-yc8q62z8	67	39	)	)	-RRB-
cord-295559-yc8q62z8	67	40	[	[	-LRB-
cord-295559-yc8q62z8	67	41	41	41	CD
cord-295559-yc8q62z8	67	42	]	]	-RRB-
cord-295559-yc8q62z8	67	43	.	.	.
cord-295559-yc8q62z8	68	1	Since	since	IN
cord-295559-yc8q62z8	68	2	cell	cell	NN
cord-295559-yc8q62z8	68	3	entry	entry	NN
cord-295559-yc8q62z8	68	4	mediated	mediate	VBN
cord-295559-yc8q62z8	68	5	by	by	IN
cord-295559-yc8q62z8	68	6	VSV	VSV	NNP
cord-295559-yc8q62z8	68	7	-	-	HYPH
cord-295559-yc8q62z8	68	8	g	g	NNP
cord-295559-yc8q62z8	68	9	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	68	10	does	do	VBZ
cord-295559-yc8q62z8	68	11	not	not	RB
cord-295559-yc8q62z8	68	12	require	require	VB
cord-295559-yc8q62z8	68	13	protease	protease	NN
cord-295559-yc8q62z8	68	14	activation	activation	NN
cord-295559-yc8q62z8	68	15	[	[	-LRB-
cord-295559-yc8q62z8	68	16	17	17	CD
cord-295559-yc8q62z8	68	17	]	]	-RRB-
cord-295559-yc8q62z8	68	18	,	,	,
cord-295559-yc8q62z8	68	19	E64D	e64d	JJ
cord-295559-yc8q62z8	68	20	treatment	treatment	NN
cord-295559-yc8q62z8	68	21	of	of	IN
cord-295559-yc8q62z8	68	22	Vero	Vero	NNP
cord-295559-yc8q62z8	68	23	E6	E6	NNP
cord-295559-yc8q62z8	68	24	(	(	-LRB-
cord-295559-yc8q62z8	68	25	Figure	figure	NN
cord-295559-yc8q62z8	68	26	3B	3b	CD
cord-295559-yc8q62z8	68	27	)	)	-RRB-
cord-295559-yc8q62z8	68	28	and	and	CC
cord-295559-yc8q62z8	68	29	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	68	30	cells	cell	NNS
cord-295559-yc8q62z8	68	31	(	(	-LRB-
cord-295559-yc8q62z8	68	32	data	datum	NNS
cord-295559-yc8q62z8	68	33	not	not	RB
cord-295559-yc8q62z8	68	34	shown	show	VBN
cord-295559-yc8q62z8	68	35	)	)	-RRB-
cord-295559-yc8q62z8	69	1	did	do	VBD
cord-295559-yc8q62z8	69	2	not	not	RB
cord-295559-yc8q62z8	69	3	inhibit	inhibit	VB
cord-295559-yc8q62z8	69	4	entry	entry	NN
cord-295559-yc8q62z8	69	5	of	of	IN
cord-295559-yc8q62z8	69	6	VSV	VSV	NNP
cord-295559-yc8q62z8	69	7	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	69	8	.	.	.
cord-295559-yc8q62z8	70	1	However	however	RB
cord-295559-yc8q62z8	70	2	,	,	,
cord-295559-yc8q62z8	70	3	E64D	e64d	NN
cord-295559-yc8q62z8	70	4	decreased	decrease	VBD
cord-295559-yc8q62z8	70	5	entry	entry	NN
cord-295559-yc8q62z8	70	6	into	into	IN
cord-295559-yc8q62z8	70	7	Vero	Vero	NNP
cord-295559-yc8q62z8	70	8	E6	E6	NNP
cord-295559-yc8q62z8	70	9	cells	cell	NNS
cord-295559-yc8q62z8	70	10	of	of	IN
cord-295559-yc8q62z8	70	11	MERS	MERS	NNP
cord-295559-yc8q62z8	70	12	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	70	13	with	with	IN
cord-295559-yc8q62z8	70	14	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	70	15	S	S	NNP
cord-295559-yc8q62z8	70	16	by	by	IN
cord-295559-yc8q62z8	70	17	96.7	96.7	CD
cord-295559-yc8q62z8	70	18	%	%	NN
cord-295559-yc8q62z8	70	19	(	(	-LRB-
cord-295559-yc8q62z8	70	20	Figure	figure	NN
cord-295559-yc8q62z8	70	21	3B	3b	CD
cord-295559-yc8q62z8	70	22	)	)	-RRB-
cord-295559-yc8q62z8	70	23	and	and	CC
cord-295559-yc8q62z8	70	24	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	70	25	cells	cell	NNS
cord-295559-yc8q62z8	70	26	by	by	IN
cord-295559-yc8q62z8	70	27	99.2	99.2	CD
cord-295559-yc8q62z8	70	28	%	%	NN
cord-295559-yc8q62z8	70	29	(	(	-LRB-
cord-295559-yc8q62z8	70	30	data	datum	NNS
cord-295559-yc8q62z8	70	31	not	not	RB
cord-295559-yc8q62z8	70	32	shown	show	VBN
cord-295559-yc8q62z8	70	33	)	)	-RRB-
cord-295559-yc8q62z8	70	34	.	.	.
cord-295559-yc8q62z8	71	1	Thus	thus	RB
cord-295559-yc8q62z8	71	2	,	,	,
cord-295559-yc8q62z8	71	3	cleavage	cleavage	NN
cord-295559-yc8q62z8	71	4	of	of	IN
cord-295559-yc8q62z8	71	5	MERS	MERS	NNP
cord-295559-yc8q62z8	71	6	-	-	HYPH
cord-295559-yc8q62z8	71	7	CoV	CoV	NNP
cord-295559-yc8q62z8	71	8	S	S	NNP
cord-295559-yc8q62z8	71	9	protein	protein	NN
cord-295559-yc8q62z8	71	10	by	by	IN
cord-295559-yc8q62z8	71	11	one	one	CD
cord-295559-yc8q62z8	71	12	of	of	IN
cord-295559-yc8q62z8	71	13	the	the	DT
cord-295559-yc8q62z8	71	14	cathepsins	cathepsin	NNS
cord-295559-yc8q62z8	71	15	or	or	CC
cord-295559-yc8q62z8	71	16	calpain	calpain	NN
cord-295559-yc8q62z8	71	17	was	be	VBD
cord-295559-yc8q62z8	71	18	required	require	VBN
cord-295559-yc8q62z8	71	19	for	for	IN
cord-295559-yc8q62z8	71	20	triggering	trigger	VBG
cord-295559-yc8q62z8	71	21	S	s	NN
cord-295559-yc8q62z8	71	22	-	-	HYPH
cord-295559-yc8q62z8	71	23	mediated	mediate	VBN
cord-295559-yc8q62z8	71	24	membrane	membrane	NN
cord-295559-yc8q62z8	71	25	fusion	fusion	NN
cord-295559-yc8q62z8	71	26	and	and	CC
cord-295559-yc8q62z8	71	27	virus	virus	NN
cord-295559-yc8q62z8	71	28	entry	entry	NN
cord-295559-yc8q62z8	71	29	at	at	IN
cord-295559-yc8q62z8	71	30	low	low	JJ
cord-295559-yc8q62z8	71	31	pH	ph	NN
cord-295559-yc8q62z8	71	32	in	in	IN
cord-295559-yc8q62z8	71	33	endosomes	endosome	NNS
cord-295559-yc8q62z8	71	34	.	.	.
cord-295559-yc8q62z8	72	1	As	as	IN
cord-295559-yc8q62z8	72	2	previously	previously	RB
cord-295559-yc8q62z8	72	3	reported	report	VBN
cord-295559-yc8q62z8	72	4	[	[	-LRB-
cord-295559-yc8q62z8	72	5	41	41	CD
cord-295559-yc8q62z8	72	6	]	]	-RRB-
cord-295559-yc8q62z8	72	7	,	,	,
cord-295559-yc8q62z8	72	8	in	in	IN
cord-295559-yc8q62z8	72	9	Vero	Vero	NNP
cord-295559-yc8q62z8	72	10	E6	E6	NNP
cord-295559-yc8q62z8	72	11	cells	cell	NNS
cord-295559-yc8q62z8	72	12	10	10	CD
cord-295559-yc8q62z8	72	13	µM	µm	CD
cord-295559-yc8q62z8	72	14	of	of	IN
cord-295559-yc8q62z8	72	15	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	72	16	L	L	NNP
cord-295559-yc8q62z8	72	17	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	72	18	III	III	NNP
cord-295559-yc8q62z8	72	19	,	,	,
cord-295559-yc8q62z8	72	20	a	a	DT
cord-295559-yc8q62z8	72	21	specific	specific	JJ
cord-295559-yc8q62z8	72	22	and	and	CC
cord-295559-yc8q62z8	72	23	irreversible	irreversible	JJ
cord-295559-yc8q62z8	72	24	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	72	25	of	of	IN
cord-295559-yc8q62z8	72	26	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	72	27	L	L	NNP
cord-295559-yc8q62z8	72	28	,	,	,
cord-295559-yc8q62z8	72	29	significantly	significantly	RB
cord-295559-yc8q62z8	72	30	inhibited	inhibit	VBN
cord-295559-yc8q62z8	72	31	entry	entry	NN
cord-295559-yc8q62z8	72	32	mediated	mediate	VBN
cord-295559-yc8q62z8	72	33	by	by	IN
cord-295559-yc8q62z8	72	34	SARS	SARS	NNP
cord-295559-yc8q62z8	72	35	S	S	NNP
cord-295559-yc8q62z8	72	36	protein	protein	NN
cord-295559-yc8q62z8	72	37	,	,	,
cord-295559-yc8q62z8	72	38	but	but	CC
cord-295559-yc8q62z8	72	39	did	do	VBD
cord-295559-yc8q62z8	72	40	not	not	RB
cord-295559-yc8q62z8	72	41	inhibit	inhibit	VB
cord-295559-yc8q62z8	72	42	VSV	VSV	NNP
cord-295559-yc8q62z8	72	43	-	-	HYPH
cord-295559-yc8q62z8	72	44	g	g	NNP
cord-295559-yc8q62z8	72	45	-	-	HYPH
cord-295559-yc8q62z8	72	46	mediated	mediate	VBN
cord-295559-yc8q62z8	72	47	entry	entry	NN
cord-295559-yc8q62z8	72	48	(	(	-LRB-
cord-295559-yc8q62z8	72	49	Figure	figure	NN
cord-295559-yc8q62z8	72	50	3B	3b	CD
cord-295559-yc8q62z8	72	51	)	)	-RRB-
cord-295559-yc8q62z8	72	52	.	.	.
cord-295559-yc8q62z8	73	1	Cathepsin	Cathepsin	NNP
cord-295559-yc8q62z8	73	2	L	L	NNP
cord-295559-yc8q62z8	73	3	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	73	4	III	iii	CD
cord-295559-yc8q62z8	73	5	reduced	reduce	VBN
cord-295559-yc8q62z8	73	6	entry	entry	NN
cord-295559-yc8q62z8	73	7	into	into	IN
cord-295559-yc8q62z8	73	8	Vero	Vero	NNP
cord-295559-yc8q62z8	73	9	E6	E6	NNP
cord-295559-yc8q62z8	73	10	cells	cell	NNS
cord-295559-yc8q62z8	73	11	of	of	IN
cord-295559-yc8q62z8	73	12	MERS	MERS	NNP
cord-295559-yc8q62z8	73	13	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	73	14	with	with	IN
cord-295559-yc8q62z8	73	15	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	73	16	S	S	NNP
cord-295559-yc8q62z8	73	17	protein	protein	NN
cord-295559-yc8q62z8	73	18	by	by	IN
cord-295559-yc8q62z8	73	19	97	97	CD
cord-295559-yc8q62z8	73	20	%	%	NN
cord-295559-yc8q62z8	73	21	relative	relative	JJ
cord-295559-yc8q62z8	73	22	to	to	IN
cord-295559-yc8q62z8	73	23	entry	entry	NN
cord-295559-yc8q62z8	73	24	without	without	IN
cord-295559-yc8q62z8	73	25	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	73	26	(	(	-LRB-
cord-295559-yc8q62z8	73	27	Figure	figure	NN
cord-295559-yc8q62z8	73	28	3B	3b	CD
cord-295559-yc8q62z8	73	29	)	)	-RRB-
cord-295559-yc8q62z8	73	30	,	,	,
cord-295559-yc8q62z8	73	31	and	and	CC
cord-295559-yc8q62z8	73	32	similar	similar	JJ
cord-295559-yc8q62z8	73	33	results	result	NNS
cord-295559-yc8q62z8	73	34	were	be	VBD
cord-295559-yc8q62z8	73	35	seen	see	VBN
cord-295559-yc8q62z8	73	36	in	in	IN
cord-295559-yc8q62z8	73	37	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	73	38	cells	cell	NNS
cord-295559-yc8q62z8	73	39	(	(	-LRB-
cord-295559-yc8q62z8	73	40	data	datum	NNS
cord-295559-yc8q62z8	73	41	not	not	RB
cord-295559-yc8q62z8	73	42	shown	show	VBN
cord-295559-yc8q62z8	73	43	)	)	-RRB-
cord-295559-yc8q62z8	73	44	.	.	.
cord-295559-yc8q62z8	74	1	Thus	thus	RB
cord-295559-yc8q62z8	74	2	,	,	,
cord-295559-yc8q62z8	74	3	MERS	MERS	NNP
cord-295559-yc8q62z8	74	4	-	-	HYPH
cord-295559-yc8q62z8	74	5	CoV	CoV	NNP
cord-295559-yc8q62z8	74	6	S	S	NNP
cord-295559-yc8q62z8	74	7	protein	protein	NN
cord-295559-yc8q62z8	74	8	on	on	IN
cord-295559-yc8q62z8	74	9	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	74	10	must	must	MD
cord-295559-yc8q62z8	74	11	be	be	VB
cord-295559-yc8q62z8	74	12	cleaved	cleave	VBN
cord-295559-yc8q62z8	74	13	in	in	IN
cord-295559-yc8q62z8	74	14	endosomes	endosome	NNS
cord-295559-yc8q62z8	74	15	by	by	IN
cord-295559-yc8q62z8	74	16	the	the	DT
cord-295559-yc8q62z8	74	17	acidactivated	acidactivate	VBN
cord-295559-yc8q62z8	74	18	cysteine	cysteine	NN
cord-295559-yc8q62z8	74	19	protease	protease	NN
cord-295559-yc8q62z8	74	20	activity	activity	NN
cord-295559-yc8q62z8	74	21	of	of	IN
cord-295559-yc8q62z8	74	22	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	74	23	L	l	NN
cord-295559-yc8q62z8	74	24	to	to	TO
cord-295559-yc8q62z8	74	25	trigger	trigger	VB
cord-295559-yc8q62z8	74	26	receptor	receptor	NN
cord-295559-yc8q62z8	74	27	-	-	HYPH
cord-295559-yc8q62z8	74	28	dependent	dependent	JJ
cord-295559-yc8q62z8	74	29	entry	entry	NN
cord-295559-yc8q62z8	74	30	into	into	IN
cord-295559-yc8q62z8	74	31	Vero	Vero	NNP
cord-295559-yc8q62z8	74	32	E6	E6	NNP
cord-295559-yc8q62z8	74	33	and	and	CC
cord-295559-yc8q62z8	74	34	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	74	35	cells	cell	NNS
cord-295559-yc8q62z8	74	36	.	.	.
cord-295559-yc8q62z8	75	1	Trypsin	Trypsin	NNP
cord-295559-yc8q62z8	75	2	cleavage	cleavage	NN
cord-295559-yc8q62z8	75	3	of	of	IN
cord-295559-yc8q62z8	75	4	MERS	MERS	NNP
cord-295559-yc8q62z8	75	5	-	-	HYPH
cord-295559-yc8q62z8	75	6	CoV	CoV	NNP
cord-295559-yc8q62z8	75	7	S	S	NNP
cord-295559-yc8q62z8	75	8	on	on	IN
cord-295559-yc8q62z8	75	9	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	75	10	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	75	11	to	to	IN
cord-295559-yc8q62z8	75	12	receptors	receptor	NNS
cord-295559-yc8q62z8	75	13	on	on	IN
cord-295559-yc8q62z8	75	14	the	the	DT
cord-295559-yc8q62z8	75	15	cell	cell	NN
cord-295559-yc8q62z8	75	16	surface	surface	NN
cord-295559-yc8q62z8	75	17	triggers	trigger	VBZ
cord-295559-yc8q62z8	75	18	virus	virus	NN
cord-295559-yc8q62z8	75	19	entry	entry	NN
cord-295559-yc8q62z8	75	20	at	at	IN
cord-295559-yc8q62z8	75	21	the	the	DT
cord-295559-yc8q62z8	75	22	plasma	plasma	NN
cord-295559-yc8q62z8	75	23	membrane	membrane	NN
cord-295559-yc8q62z8	75	24	at	at	IN
cord-295559-yc8q62z8	75	25	neutral	neutral	JJ
cord-295559-yc8q62z8	75	26	pH	pH	NNP
cord-295559-yc8q62z8	75	27	SARS	SARS	NNP
cord-295559-yc8q62z8	75	28	-	-	HYPH
cord-295559-yc8q62z8	75	29	CoV	CoV	NNP
cord-295559-yc8q62z8	75	30	can	can	MD
cord-295559-yc8q62z8	75	31	enter	enter	VB
cord-295559-yc8q62z8	75	32	susceptible	susceptible	JJ
cord-295559-yc8q62z8	75	33	cells	cell	NNS
cord-295559-yc8q62z8	75	34	at	at	IN
cord-295559-yc8q62z8	75	35	the	the	DT
cord-295559-yc8q62z8	75	36	plasma	plasma	NN
cord-295559-yc8q62z8	75	37	membrane	membrane	NN
cord-295559-yc8q62z8	75	38	,	,	,
cord-295559-yc8q62z8	75	39	instead	instead	RB
cord-295559-yc8q62z8	75	40	of	of	IN
cord-295559-yc8q62z8	75	41	by	by	IN
cord-295559-yc8q62z8	75	42	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	75	43	,	,	,
cord-295559-yc8q62z8	75	44	if	if	IN
cord-295559-yc8q62z8	75	45	virions	virion	NNS
cord-295559-yc8q62z8	75	46	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	75	47	at	at	IN
cord-295559-yc8q62z8	75	48	4	4	CD
cord-295559-yc8q62z8	75	49	°	°	NN
cord-295559-yc8q62z8	75	50	C	c	NN
cord-295559-yc8q62z8	75	51	to	to	IN
cord-295559-yc8q62z8	75	52	ACE2	ACE2	NNP
cord-295559-yc8q62z8	75	53	on	on	IN
cord-295559-yc8q62z8	75	54	the	the	DT
cord-295559-yc8q62z8	75	55	cell	cell	NN
cord-295559-yc8q62z8	75	56	membrane	membrane	NN
cord-295559-yc8q62z8	75	57	are	be	VBP
cord-295559-yc8q62z8	75	58	treated	treat	VBN
cord-295559-yc8q62z8	75	59	with	with	IN
cord-295559-yc8q62z8	75	60	trypsin	trypsin	NN
cord-295559-yc8q62z8	75	61	,	,	,
cord-295559-yc8q62z8	75	62	then	then	RB
cord-295559-yc8q62z8	75	63	warmed	warm	VBD
cord-295559-yc8q62z8	75	64	to	to	IN
cord-295559-yc8q62z8	75	65	37	37	CD
cord-295559-yc8q62z8	75	66	°	°	NN
cord-295559-yc8q62z8	75	67	C	c	NN
cord-295559-yc8q62z8	75	68	in	in	IN
cord-295559-yc8q62z8	75	69	the	the	DT
cord-295559-yc8q62z8	75	70	presence	presence	NN
cord-295559-yc8q62z8	75	71	of	of	IN
cord-295559-yc8q62z8	75	72	an	an	DT
cord-295559-yc8q62z8	75	73	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	75	74	of	of	IN
cord-295559-yc8q62z8	75	75	endosomal	endosomal	NNP
cord-295559-yc8q62z8	75	76	acidification	acidification	NN
cord-295559-yc8q62z8	75	77	[	[	-LRB-
cord-295559-yc8q62z8	75	78	21	21	CD
cord-295559-yc8q62z8	75	79	]	]	-RRB-
cord-295559-yc8q62z8	75	80	.	.	.
cord-295559-yc8q62z8	76	1	Trypsin	Trypsin	NNP
cord-295559-yc8q62z8	76	2	treatment	treatment	NN
cord-295559-yc8q62z8	76	3	at	at	IN
cord-295559-yc8q62z8	76	4	either	either	DT
cord-295559-yc8q62z8	76	5	4	4	CD
cord-295559-yc8q62z8	76	6	°	°	NN
cord-295559-yc8q62z8	76	7	C	c	NN
cord-295559-yc8q62z8	76	8	or	or	CC
cord-295559-yc8q62z8	76	9	37	37	CD
cord-295559-yc8q62z8	76	10	°	°	NN
cord-295559-yc8q62z8	77	1	C	C	NNP
cord-295559-yc8q62z8	77	2	cleaved	cleave	VBD
cord-295559-yc8q62z8	77	3	the	the	DT
cord-295559-yc8q62z8	77	4	S	S	NNP
cord-295559-yc8q62z8	77	5	protein	protein	NN
cord-295559-yc8q62z8	77	6	of	of	IN
cord-295559-yc8q62z8	77	7	MERS	MERS	NNP
cord-295559-yc8q62z8	77	8	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	77	9	and	and	CC
cord-295559-yc8q62z8	77	10	generated	generate	VBD
cord-295559-yc8q62z8	77	11	a	a	DT
cord-295559-yc8q62z8	77	12	~65kDa	~65kDa	NNP
cord-295559-yc8q62z8	77	13	subunit	subunit	NN
cord-295559-yc8q62z8	77	14	in	in	IN
cord-295559-yc8q62z8	77	15	the	the	DT
cord-295559-yc8q62z8	77	16	S2	S2	NNP
cord-295559-yc8q62z8	77	17	domain	domain	NN
cord-295559-yc8q62z8	77	18	of	of	IN
cord-295559-yc8q62z8	77	19	the	the	DT
cord-295559-yc8q62z8	77	20	protein	protein	NN
cord-295559-yc8q62z8	77	21	recognized	recognize	VBN
cord-295559-yc8q62z8	77	22	by	by	IN
cord-295559-yc8q62z8	77	23	antibody	antibody	NN
cord-295559-yc8q62z8	77	24	to	to	IN
cord-295559-yc8q62z8	77	25	MHV	MHV	NNP
cord-295559-yc8q62z8	77	26	-	-	HYPH
cord-295559-yc8q62z8	77	27	A59	A59	NNP
cord-295559-yc8q62z8	77	28	S	S	NNP
cord-295559-yc8q62z8	77	29	protein	protein	NN
cord-295559-yc8q62z8	77	30	(	(	-LRB-
cord-295559-yc8q62z8	77	31	Figure	Figure	NNP
cord-295559-yc8q62z8	77	32	S1	S1	NNP
cord-295559-yc8q62z8	77	33	)	)	-RRB-
cord-295559-yc8q62z8	77	34	.	.	.
cord-295559-yc8q62z8	78	1	MERS	MERS	NNP
cord-295559-yc8q62z8	78	2	pseudovirions	pseudovirion	VBZ
cord-295559-yc8q62z8	78	3	with	with	IN
cord-295559-yc8q62z8	78	4	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	78	5	S	S	NNP
cord-295559-yc8q62z8	78	6	protein	protein	NN
cord-295559-yc8q62z8	78	7	were	be	VBD
cord-295559-yc8q62z8	78	8	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	78	9	at	at	IN
cord-295559-yc8q62z8	78	10	4	4	CD
cord-295559-yc8q62z8	78	11	°	°	NN
cord-295559-yc8q62z8	78	12	C	c	NN
cord-295559-yc8q62z8	78	13	to	to	IN
cord-295559-yc8q62z8	78	14	cell	cell	NN
cord-295559-yc8q62z8	78	15	surface	surface	NN
cord-295559-yc8q62z8	78	16	receptors	receptor	NNS
cord-295559-yc8q62z8	78	17	on	on	IN
cord-295559-yc8q62z8	78	18	Vero	Vero	NNP
cord-295559-yc8q62z8	78	19	E6	E6	NNP
cord-295559-yc8q62z8	78	20	cells	cell	NNS
cord-295559-yc8q62z8	78	21	in	in	IN
cord-295559-yc8q62z8	78	22	the	the	DT
cord-295559-yc8q62z8	78	23	presence	presence	NN
cord-295559-yc8q62z8	78	24	of	of	IN
cord-295559-yc8q62z8	78	25	20mM	20mm	CD
cord-295559-yc8q62z8	78	26	NH	NH	NNP
cord-295559-yc8q62z8	78	27	4	4	CD
cord-295559-yc8q62z8	78	28	Cl	Cl	NNP
cord-295559-yc8q62z8	78	29	,	,	,
cord-295559-yc8q62z8	78	30	and	and	CC
cord-295559-yc8q62z8	78	31	then	then	RB
cord-295559-yc8q62z8	78	32	the	the	DT
cord-295559-yc8q62z8	78	33	cells	cell	NNS
cord-295559-yc8q62z8	78	34	with	with	IN
cord-295559-yc8q62z8	78	35	bound	bind	VBN
cord-295559-yc8q62z8	78	36	virions	virion	NNS
cord-295559-yc8q62z8	78	37	were	be	VBD
cord-295559-yc8q62z8	78	38	briefly	briefly	RB
cord-295559-yc8q62z8	78	39	treated	treat	VBN
cord-295559-yc8q62z8	78	40	with	with	IN
cord-295559-yc8q62z8	78	41	trypsin	trypsin	NN
cord-295559-yc8q62z8	78	42	at	at	IN
cord-295559-yc8q62z8	78	43	pH	pH	NNP
cord-295559-yc8q62z8	78	44	7.4	7.4	CD
cord-295559-yc8q62z8	78	45	at	at	IN
cord-295559-yc8q62z8	78	46	room	room	NN
cord-295559-yc8q62z8	78	47	temperature	temperature	NN
cord-295559-yc8q62z8	78	48	to	to	TO
cord-295559-yc8q62z8	78	49	cleave	cleave	VB
cord-295559-yc8q62z8	78	50	the	the	DT
cord-295559-yc8q62z8	78	51	~200	~200	NN
cord-295559-yc8q62z8	78	52	kDa	kDa	NNP
cord-295559-yc8q62z8	78	53	S	S	NNP
cord-295559-yc8q62z8	78	54	protein	protein	NN
cord-295559-yc8q62z8	78	55	and	and	CC
cord-295559-yc8q62z8	78	56	activate	activate	VB
cord-295559-yc8q62z8	78	57	its	-PRON-	PRP$
cord-295559-yc8q62z8	78	58	membrane	membrane	NN
cord-295559-yc8q62z8	78	59	fusing	fuse	VBG
cord-295559-yc8q62z8	78	60	activity	activity	NN
cord-295559-yc8q62z8	78	61	.	.	.
cord-295559-yc8q62z8	79	1	Figures	figure	NNS
cord-295559-yc8q62z8	79	2	3A	3A	NNP
cord-295559-yc8q62z8	79	3	and	and	CC
cord-295559-yc8q62z8	79	4	4A	4a	CD
cord-295559-yc8q62z8	79	5	show	show	VBP
cord-295559-yc8q62z8	79	6	that	that	IN
cord-295559-yc8q62z8	79	7	NH	NH	NNP
cord-295559-yc8q62z8	79	8	4	4	CD
cord-295559-yc8q62z8	79	9	Cl	Cl	NNP
cord-295559-yc8q62z8	79	10	strongly	strongly	RB
cord-295559-yc8q62z8	79	11	inhibited	inhibit	VBD
cord-295559-yc8q62z8	79	12	infection	infection	NN
cord-295559-yc8q62z8	79	13	of	of	IN
cord-295559-yc8q62z8	79	14	Vero	Vero	NNP
cord-295559-yc8q62z8	79	15	E6	E6	NNP
cord-295559-yc8q62z8	79	16	cells	cell	NNS
cord-295559-yc8q62z8	79	17	by	by	IN
cord-295559-yc8q62z8	79	18	MERS	MERS	NNP
cord-295559-yc8q62z8	79	19	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	79	20	with	with	IN
cord-295559-yc8q62z8	79	21	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	79	22	S.	S.	NNP
cord-295559-yc8q62z8	80	1	However	however	RB
cord-295559-yc8q62z8	80	2	,	,	,
cord-295559-yc8q62z8	80	3	trypsin	trypsin	NN
cord-295559-yc8q62z8	80	4	treatment	treatment	NN
cord-295559-yc8q62z8	80	5	of	of	IN
cord-295559-yc8q62z8	80	6	the	the	DT
cord-295559-yc8q62z8	80	7	MERS	MERS	NNP
cord-295559-yc8q62z8	80	8	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	80	9	bound	bind	VBN
cord-295559-yc8q62z8	80	10	at	at	IN
cord-295559-yc8q62z8	80	11	neutral	neutral	JJ
cord-295559-yc8q62z8	80	12	pH	pH	NNP
cord-295559-yc8q62z8	80	13	and	and	CC
cord-295559-yc8q62z8	80	14	4	4	CD
cord-295559-yc8q62z8	80	15	°	°	NN
cord-295559-yc8q62z8	80	16	C	c	NN
cord-295559-yc8q62z8	80	17	to	to	IN
cord-295559-yc8q62z8	80	18	the	the	DT
cord-295559-yc8q62z8	80	19	Vero	Vero	NNP
cord-295559-yc8q62z8	80	20	E6	E6	NNP
cord-295559-yc8q62z8	80	21	cell	cell	NN
cord-295559-yc8q62z8	80	22	membrane	membrane	NN
cord-295559-yc8q62z8	80	23	triggered	trigger	VBD
cord-295559-yc8q62z8	80	24	both	both	DT
cord-295559-yc8q62z8	80	25	virus	virus	NN
cord-295559-yc8q62z8	80	26	entry	entry	NN
cord-295559-yc8q62z8	80	27	at	at	IN
cord-295559-yc8q62z8	80	28	the	the	DT
cord-295559-yc8q62z8	80	29	plasma	plasma	NN
cord-295559-yc8q62z8	80	30	membrane	membrane	NN
cord-295559-yc8q62z8	80	31	and	and	CC
cord-295559-yc8q62z8	80	32	formation	formation	NN
cord-295559-yc8q62z8	80	33	of	of	IN
cord-295559-yc8q62z8	80	34	small	small	JJ
cord-295559-yc8q62z8	80	35	syncytia	syncytia	NN
cord-295559-yc8q62z8	80	36	by	by	IN
cord-295559-yc8q62z8	80	37	40	40	CD
cord-295559-yc8q62z8	80	38	hours	hour	NNS
cord-295559-yc8q62z8	80	39	post	post	NN
cord-295559-yc8q62z8	80	40	inoculation	inoculation	NN
cord-295559-yc8q62z8	80	41	(	(	-LRB-
cord-295559-yc8q62z8	80	42	Figure	figure	NN
cord-295559-yc8q62z8	80	43	4A	4a	NN
cord-295559-yc8q62z8	80	44	and	and	CC
cord-295559-yc8q62z8	80	45	B	b	NN
cord-295559-yc8q62z8	80	46	)	)	-RRB-
cord-295559-yc8q62z8	80	47	.	.	.
cord-295559-yc8q62z8	81	1	Thus	thus	RB
cord-295559-yc8q62z8	81	2	,	,	,
cord-295559-yc8q62z8	81	3	receptor	receptor	NN
cord-295559-yc8q62z8	81	4	binding	bind	VBG
cord-295559-yc8q62z8	81	5	together	together	RB
cord-295559-yc8q62z8	81	6	with	with	IN
cord-295559-yc8q62z8	81	7	protease	protease	NN
cord-295559-yc8q62z8	81	8	cleavage	cleavage	NN
cord-295559-yc8q62z8	81	9	and	and	CC
cord-295559-yc8q62z8	81	10	activation	activation	NN
cord-295559-yc8q62z8	81	11	of	of	IN
cord-295559-yc8q62z8	81	12	S	S	NNP
cord-295559-yc8q62z8	81	13	at	at	IN
cord-295559-yc8q62z8	81	14	neutral	neutral	JJ
cord-295559-yc8q62z8	81	15	pH	pH	NNP
cord-295559-yc8q62z8	81	16	was	be	VBD
cord-295559-yc8q62z8	81	17	sufficient	sufficient	JJ
cord-295559-yc8q62z8	81	18	to	to	TO
cord-295559-yc8q62z8	81	19	trigger	trigger	VB
cord-295559-yc8q62z8	81	20	entry	entry	NN
cord-295559-yc8q62z8	81	21	of	of	IN
cord-295559-yc8q62z8	81	22	MERS	MERS	NNP
cord-295559-yc8q62z8	81	23	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	81	24	and	and	CC
cord-295559-yc8q62z8	81	25	syncytia	syncytia	NN
cord-295559-yc8q62z8	81	26	formation	formation	NN
cord-295559-yc8q62z8	81	27	.	.	.
cord-295559-yc8q62z8	82	1	In	in	IN
cord-295559-yc8q62z8	82	2	this	this	DT
cord-295559-yc8q62z8	82	3	experiment	experiment	NN
cord-295559-yc8q62z8	82	4	membrane	membrane	NN
cord-295559-yc8q62z8	82	5	fusion	fusion	NN
cord-295559-yc8q62z8	82	6	did	do	VBD
cord-295559-yc8q62z8	82	7	not	not	RB
cord-295559-yc8q62z8	82	8	depend	depend	VB
cord-295559-yc8q62z8	82	9	upon	upon	IN
cord-295559-yc8q62z8	82	10	synthesis	synthesis	NN
cord-295559-yc8q62z8	82	11	of	of	IN
cord-295559-yc8q62z8	82	12	S	s	NN
cord-295559-yc8q62z8	82	13	protein	protein	NN
cord-295559-yc8q62z8	82	14	,	,	,
cord-295559-yc8q62z8	82	15	but	but	CC
cord-295559-yc8q62z8	82	16	syncytia	syncytia	NN
cord-295559-yc8q62z8	82	17	formation	formation	NN
cord-295559-yc8q62z8	82	18	was	be	VBD
cord-295559-yc8q62z8	82	19	mediated	mediate	VBN
cord-295559-yc8q62z8	82	20	by	by	IN
cord-295559-yc8q62z8	82	21	the	the	DT
cord-295559-yc8q62z8	82	22	cleaved	cleaved	JJ
cord-295559-yc8q62z8	82	23	S	S	NNP
cord-295559-yc8q62z8	82	24	protein	protein	NN
cord-295559-yc8q62z8	82	25	on	on	IN
cord-295559-yc8q62z8	82	26	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	82	27	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	82	28	to	to	IN
cord-295559-yc8q62z8	82	29	virus	virus	NN
cord-295559-yc8q62z8	82	30	receptor	receptor	NN
cord-295559-yc8q62z8	82	31	on	on	IN
cord-295559-yc8q62z8	82	32	the	the	DT
cord-295559-yc8q62z8	82	33	cell	cell	NN
cord-295559-yc8q62z8	82	34	membrane	membrane	NN
cord-295559-yc8q62z8	82	35	.	.	.
cord-295559-yc8q62z8	83	1	Although	although	IN
cord-295559-yc8q62z8	83	2	acidic	acidic	JJ
cord-295559-yc8q62z8	83	3	pH	ph	NN
cord-295559-yc8q62z8	83	4	is	be	VBZ
cord-295559-yc8q62z8	83	5	required	require	VBN
cord-295559-yc8q62z8	83	6	to	to	TO
cord-295559-yc8q62z8	83	7	activate	activate	VB
cord-295559-yc8q62z8	83	8	the	the	DT
cord-295559-yc8q62z8	83	9	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	83	10	L	l	NN
cord-295559-yc8q62z8	83	11	activity	activity	NN
cord-295559-yc8q62z8	83	12	that	that	WDT
cord-295559-yc8q62z8	83	13	allows	allow	VBZ
cord-295559-yc8q62z8	83	14	MERS	MERS	NNP
cord-295559-yc8q62z8	83	15	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	83	16	to	to	TO
cord-295559-yc8q62z8	83	17	enter	enter	VB
cord-295559-yc8q62z8	83	18	at	at	IN
cord-295559-yc8q62z8	83	19	endosomes	endosome	NNS
cord-295559-yc8q62z8	83	20	,	,	,
cord-295559-yc8q62z8	83	21	low	low	JJ
cord-295559-yc8q62z8	83	22	pH	ph	NN
cord-295559-yc8q62z8	83	23	is	be	VBZ
cord-295559-yc8q62z8	83	24	not	not	RB
cord-295559-yc8q62z8	83	25	required	require	VBN
cord-295559-yc8q62z8	83	26	for	for	IN
cord-295559-yc8q62z8	83	27	the	the	DT
cord-295559-yc8q62z8	83	28	conformational	conformational	JJ
cord-295559-yc8q62z8	83	29	changes	change	NNS
cord-295559-yc8q62z8	83	30	in	in	IN
cord-295559-yc8q62z8	83	31	trypsin	trypsin	NN
cord-295559-yc8q62z8	83	32	-	-	HYPH
cord-295559-yc8q62z8	83	33	cleaved	cleave	VBN
cord-295559-yc8q62z8	83	34	MERS	MERS	NNP
cord-295559-yc8q62z8	83	35	-	-	HYPH
cord-295559-yc8q62z8	83	36	CoV	CoV	NNP
cord-295559-yc8q62z8	83	37	S	S	NNP
cord-295559-yc8q62z8	83	38	protein	protein	NN
cord-295559-yc8q62z8	83	39	that	that	WDT
cord-295559-yc8q62z8	83	40	mediate	mediate	VBP
cord-295559-yc8q62z8	83	41	entry	entry	NN
cord-295559-yc8q62z8	83	42	at	at	IN
cord-295559-yc8q62z8	83	43	the	the	DT
cord-295559-yc8q62z8	83	44	plasma	plasma	NN
cord-295559-yc8q62z8	83	45	membrane	membrane	NN
cord-295559-yc8q62z8	83	46	.	.	.
cord-295559-yc8q62z8	84	1	293	293	CD
cord-295559-yc8q62z8	84	2	T	t	NN
cord-295559-yc8q62z8	84	3	cells	cell	NNS
cord-295559-yc8q62z8	84	4	expressing	express	VBG
cord-295559-yc8q62z8	84	5	uncleaved	uncleave	VBN
cord-295559-yc8q62z8	84	6	MERS	MERS	NNP
cord-295559-yc8q62z8	84	7	-	-	HYPH
cord-295559-yc8q62z8	84	8	CoV	CoV	NNP
cord-295559-yc8q62z8	84	9	S	S	NNP
cord-295559-yc8q62z8	84	10	protein	protein	NN
cord-295559-yc8q62z8	84	11	or	or	CC
cord-295559-yc8q62z8	84	12	control	control	NN
cord-295559-yc8q62z8	84	13	cells	cell	NNS
cord-295559-yc8q62z8	84	14	stably	stably	RB
cord-295559-yc8q62z8	84	15	transfected	transfecte	VBN
cord-295559-yc8q62z8	84	16	with	with	IN
cord-295559-yc8q62z8	84	17	the	the	DT
cord-295559-yc8q62z8	84	18	empty	empty	JJ
cord-295559-yc8q62z8	84	19	pcDNA3.1	pcDNA3.1	:
cord-295559-yc8q62z8	84	20	vector	vector	NN
cord-295559-yc8q62z8	84	21	were	be	VBD
cord-295559-yc8q62z8	84	22	overlaid	overlay	VBN
cord-295559-yc8q62z8	84	23	on	on	IN
cord-295559-yc8q62z8	84	24	monolayers	monolayer	NNS
cord-295559-yc8q62z8	84	25	of	of	IN
cord-295559-yc8q62z8	84	26	Vero	Vero	NNP
cord-295559-yc8q62z8	84	27	E6	E6	NNP
cord-295559-yc8q62z8	84	28	cells	cell	NNS
cord-295559-yc8q62z8	84	29	in	in	IN
cord-295559-yc8q62z8	84	30	the	the	DT
cord-295559-yc8q62z8	84	31	presence	presence	NN
cord-295559-yc8q62z8	84	32	or	or	CC
cord-295559-yc8q62z8	84	33	absence	absence	NN
cord-295559-yc8q62z8	84	34	of	of	IN
cord-295559-yc8q62z8	84	35	TPCK	TPCK	NNP
cord-295559-yc8q62z8	84	36	trypsin	trypsin	NN
cord-295559-yc8q62z8	84	37	(	(	-LRB-
cord-295559-yc8q62z8	84	38	Figure	figure	NN
cord-295559-yc8q62z8	84	39	4C	4c	CD
cord-295559-yc8q62z8	84	40	)	)	-RRB-
cord-295559-yc8q62z8	84	41	.	.	.
cord-295559-yc8q62z8	85	1	No	no	DT
cord-295559-yc8q62z8	85	2	syncytia	syncytia	NN
cord-295559-yc8q62z8	85	3	formation	formation	NN
cord-295559-yc8q62z8	85	4	was	be	VBD
cord-295559-yc8q62z8	85	5	induced	induce	VBN
cord-295559-yc8q62z8	85	6	by	by	IN
cord-295559-yc8q62z8	85	7	293	293	CD
cord-295559-yc8q62z8	85	8	T	t	NN
cord-295559-yc8q62z8	85	9	cells	cell	NNS
cord-295559-yc8q62z8	85	10	with	with	IN
cord-295559-yc8q62z8	85	11	empty	empty	JJ
cord-295559-yc8q62z8	85	12	vector	vector	NN
cord-295559-yc8q62z8	85	13	or	or	CC
cord-295559-yc8q62z8	85	14	293	293	CD
cord-295559-yc8q62z8	85	15	T	t	NN
cord-295559-yc8q62z8	85	16	cells	cell	NNS
cord-295559-yc8q62z8	85	17	expressing	express	VBG
cord-295559-yc8q62z8	85	18	MERS	MERS	NNP
cord-295559-yc8q62z8	85	19	-	-	HYPH
cord-295559-yc8q62z8	85	20	CoV	cov	NN
cord-295559-yc8q62z8	85	21	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	85	22	without	without	IN
cord-295559-yc8q62z8	85	23	trypsin	trypsin	NN
cord-295559-yc8q62z8	85	24	(	(	-LRB-
cord-295559-yc8q62z8	85	25	Figure	figure	NN
cord-295559-yc8q62z8	85	26	4C	4c	CD
cord-295559-yc8q62z8	85	27	)	)	-RRB-
cord-295559-yc8q62z8	85	28	,	,	,
cord-295559-yc8q62z8	85	29	but	but	CC
cord-295559-yc8q62z8	85	30	addition	addition	NN
cord-295559-yc8q62z8	85	31	of	of	IN
cord-295559-yc8q62z8	85	32	TPCK	TPCK	NNP
cord-295559-yc8q62z8	85	33	trypsin	trypsin	NN
cord-295559-yc8q62z8	85	34	to	to	IN
cord-295559-yc8q62z8	85	35	the	the	DT
cord-295559-yc8q62z8	85	36	medium	medium	NN
cord-295559-yc8q62z8	85	37	triggered	trigger	VBN
cord-295559-yc8q62z8	85	38	formation	formation	NN
cord-295559-yc8q62z8	85	39	of	of	IN
cord-295559-yc8q62z8	85	40	massive	massive	JJ
cord-295559-yc8q62z8	85	41	syncytia	syncytia	NN
cord-295559-yc8q62z8	85	42	in	in	IN
cord-295559-yc8q62z8	85	43	the	the	DT
cord-295559-yc8q62z8	85	44	Vero	Vero	NNP
cord-295559-yc8q62z8	85	45	E6	E6	NNP
cord-295559-yc8q62z8	85	46	cells	cell	NNS
cord-295559-yc8q62z8	85	47	co	co	VBD
cord-295559-yc8q62z8	85	48	-	-	NN
cord-295559-yc8q62z8	85	49	cultured	cultured	JJ
cord-295559-yc8q62z8	85	50	for	for	IN
cord-295559-yc8q62z8	85	51	20	20	CD
cord-295559-yc8q62z8	85	52	hr	hr	NN
cord-295559-yc8q62z8	85	53	with	with	IN
cord-295559-yc8q62z8	85	54	MERS	MERS	NNP
cord-295559-yc8q62z8	85	55	-	-	HYPH
cord-295559-yc8q62z8	85	56	CoV	CoV	NNP
cord-295559-yc8q62z8	85	57	S	S	NNP
cord-295559-yc8q62z8	85	58	-	-	HYPH
cord-295559-yc8q62z8	85	59	expressing	express	VBG
cord-295559-yc8q62z8	85	60	293	293	CD
cord-295559-yc8q62z8	85	61	T	T	NNP
cord-295559-yc8q62z8	85	62	cells	cell	NNS
cord-295559-yc8q62z8	85	63	(	(	-LRB-
cord-295559-yc8q62z8	85	64	Figure	figure	NN
cord-295559-yc8q62z8	85	65	4C	4c	CD
cord-295559-yc8q62z8	85	66	,	,	,
cord-295559-yc8q62z8	85	67	arrows	arrow	NNS
cord-295559-yc8q62z8	85	68	)	)	-RRB-
cord-295559-yc8q62z8	85	69	.	.	.
cord-295559-yc8q62z8	86	1	Large	large	JJ
cord-295559-yc8q62z8	86	2	syncytia	syncytia	NN
cord-295559-yc8q62z8	86	3	were	be	VBD
cord-295559-yc8q62z8	86	4	also	also	RB
cord-295559-yc8q62z8	86	5	formed	form	VBN
cord-295559-yc8q62z8	86	6	after	after	IN
cord-295559-yc8q62z8	86	7	even	even	RB
cord-295559-yc8q62z8	86	8	a	a	DT
cord-295559-yc8q62z8	86	9	brief	brief	JJ
cord-295559-yc8q62z8	86	10	20	20	CD
cord-295559-yc8q62z8	86	11	minute	minute	NN
cord-295559-yc8q62z8	86	12	trypsin	trypsin	NN
cord-295559-yc8q62z8	86	13	pre	pre	NN
cord-295559-yc8q62z8	86	14	-	-	NN
cord-295559-yc8q62z8	86	15	treatment	treatment	NN
cord-295559-yc8q62z8	86	16	at	at	IN
cord-295559-yc8q62z8	86	17	pH	pH	NNP
cord-295559-yc8q62z8	86	18	7.4	7.4	CD
cord-295559-yc8q62z8	86	19	and	and	CC
cord-295559-yc8q62z8	86	20	4	4	CD
cord-295559-yc8q62z8	86	21	°	°	NN
cord-295559-yc8q62z8	86	22	C	c	NN
cord-295559-yc8q62z8	86	23	of	of	IN
cord-295559-yc8q62z8	86	24	293	293	CD
cord-295559-yc8q62z8	86	25	T	t	NN
cord-295559-yc8q62z8	86	26	cells	cell	NNS
cord-295559-yc8q62z8	86	27	expressing	express	VBG
cord-295559-yc8q62z8	86	28	MERS	MERS	NNP
cord-295559-yc8q62z8	86	29	-	-	HYPH
cord-295559-yc8q62z8	86	30	CoV	CoV	NNP
cord-295559-yc8q62z8	86	31	S	S	NNP
cord-295559-yc8q62z8	86	32	protein	protein	NN
cord-295559-yc8q62z8	86	33	,	,	,
cord-295559-yc8q62z8	86	34	followed	follow	VBN
cord-295559-yc8q62z8	86	35	by	by	IN
cord-295559-yc8q62z8	86	36	incubation	incubation	NN
cord-295559-yc8q62z8	86	37	with	with	IN
cord-295559-yc8q62z8	86	38	a	a	DT
cord-295559-yc8q62z8	86	39	5-fold	5-fold	CD
cord-295559-yc8q62z8	86	40	excess	excess	NN
cord-295559-yc8q62z8	86	41	of	of	IN
cord-295559-yc8q62z8	86	42	soybean	soybean	NN
cord-295559-yc8q62z8	86	43	trypsin	trypsin	NN
cord-295559-yc8q62z8	86	44	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	86	45	before	before	IN
cord-295559-yc8q62z8	86	46	layering	layer	VBG
cord-295559-yc8q62z8	86	47	the	the	DT
cord-295559-yc8q62z8	86	48	cells	cell	NNS
cord-295559-yc8q62z8	86	49	over	over	IN
cord-295559-yc8q62z8	86	50	confluent	confluent	JJ
cord-295559-yc8q62z8	86	51	monolayers	monolayer	NNS
cord-295559-yc8q62z8	86	52	of	of	IN
cord-295559-yc8q62z8	86	53	Vero	Vero	NNP
cord-295559-yc8q62z8	86	54	E6	E6	NNP
cord-295559-yc8q62z8	86	55	cells	cell	NNS
cord-295559-yc8q62z8	86	56	and	and	CC
cord-295559-yc8q62z8	86	57	incubating	incubate	VBG
cord-295559-yc8q62z8	86	58	at	at	IN
cord-295559-yc8q62z8	86	59	37	37	CD
cord-295559-yc8q62z8	86	60	°	°	NN
cord-295559-yc8q62z8	86	61	C	c	NN
cord-295559-yc8q62z8	86	62	for	for	IN
cord-295559-yc8q62z8	86	63	20	20	CD
cord-295559-yc8q62z8	86	64	hours	hour	NNS
cord-295559-yc8q62z8	86	65	(	(	-LRB-
cord-295559-yc8q62z8	86	66	Figure	figure	NN
cord-295559-yc8q62z8	86	67	4C	4c	CD
cord-295559-yc8q62z8	86	68	,	,	,
cord-295559-yc8q62z8	86	69	lower	low	JJR
cord-295559-yc8q62z8	86	70	central	central	JJ
cord-295559-yc8q62z8	86	71	panel	panel	NN
cord-295559-yc8q62z8	86	72	,	,	,
cord-295559-yc8q62z8	86	73	arrows	arrow	NNS
cord-295559-yc8q62z8	86	74	)	)	-RRB-
cord-295559-yc8q62z8	86	75	.	.	.
cord-295559-yc8q62z8	87	1	Thus	thus	RB
cord-295559-yc8q62z8	87	2	,	,	,
cord-295559-yc8q62z8	87	3	trypsin	trypsin	NN
cord-295559-yc8q62z8	87	4	cleavage	cleavage	NN
cord-295559-yc8q62z8	87	5	at	at	IN
cord-295559-yc8q62z8	87	6	neutral	neutral	JJ
cord-295559-yc8q62z8	87	7	pH	ph	NN
cord-295559-yc8q62z8	87	8	of	of	IN
cord-295559-yc8q62z8	87	9	MERS	MERS	NNP
cord-295559-yc8q62z8	87	10	-	-	HYPH
cord-295559-yc8q62z8	87	11	CoV	CoV	NNP
cord-295559-yc8q62z8	87	12	S	S	NNP
cord-295559-yc8q62z8	87	13	protein	protein	NN
cord-295559-yc8q62z8	87	14	on	on	IN
cord-295559-yc8q62z8	87	15	293	293	CD
cord-295559-yc8q62z8	87	16	T	t	NN
cord-295559-yc8q62z8	87	17	cells	cell	NNS
cord-295559-yc8q62z8	87	18	triggered	trigger	VBD
cord-295559-yc8q62z8	87	19	syncytia	syncytia	NN
cord-295559-yc8q62z8	87	20	formation	formation	NN
cord-295559-yc8q62z8	87	21	when	when	WRB
cord-295559-yc8q62z8	87	22	S	S	NNP
cord-295559-yc8q62z8	87	23	was	be	VBD
cord-295559-yc8q62z8	87	24	bound	bind	VBN
cord-295559-yc8q62z8	87	25	to	to	IN
cord-295559-yc8q62z8	87	26	receptors	receptor	NNS
cord-295559-yc8q62z8	87	27	on	on	IN
cord-295559-yc8q62z8	87	28	susceptible	susceptible	JJ
cord-295559-yc8q62z8	87	29	Vero	Vero	NNP
cord-295559-yc8q62z8	87	30	E6	E6	NNP
cord-295559-yc8q62z8	87	31	cells	cell	NNS
cord-295559-yc8q62z8	87	32	.	.	.
cord-295559-yc8q62z8	88	1	Type	Type	NNP
cord-295559-yc8q62z8	88	2	II	II	NNP
cord-295559-yc8q62z8	88	3	transmembrane	transmembrane	NN
cord-295559-yc8q62z8	88	4	serine	serine	NN
cord-295559-yc8q62z8	88	5	proteases	protease	NNS
cord-295559-yc8q62z8	88	6	,	,	,
cord-295559-yc8q62z8	88	7	including	include	VBG
cord-295559-yc8q62z8	88	8	TMPRSS-2	tmprss-2	ADD
cord-295559-yc8q62z8	88	9	and	and	CC
cord-295559-yc8q62z8	88	10	TMPRSS-4	TMPRSS-4	NNP
cord-295559-yc8q62z8	88	11	,	,	,
cord-295559-yc8q62z8	88	12	which	which	WDT
cord-295559-yc8q62z8	88	13	like	like	IN
cord-295559-yc8q62z8	88	14	trypsin	trypsin	NN
cord-295559-yc8q62z8	88	15	are	be	VBP
cord-295559-yc8q62z8	88	16	expressed	express	VBN
cord-295559-yc8q62z8	88	17	in	in	IN
cord-295559-yc8q62z8	88	18	the	the	DT
cord-295559-yc8q62z8	88	19	respiratory	respiratory	JJ
cord-295559-yc8q62z8	88	20	tract	tract	NN
cord-295559-yc8q62z8	88	21	,	,	,
cord-295559-yc8q62z8	88	22	play	play	VB
cord-295559-yc8q62z8	88	23	important	important	JJ
cord-295559-yc8q62z8	88	24	roles	role	NNS
cord-295559-yc8q62z8	88	25	in	in	IN
cord-295559-yc8q62z8	88	26	triggering	trigger	VBG
cord-295559-yc8q62z8	88	27	entry	entry	NN
cord-295559-yc8q62z8	88	28	of	of	IN
cord-295559-yc8q62z8	88	29	influenza	influenza	NN
cord-295559-yc8q62z8	88	30	A	a	DT
cord-295559-yc8q62z8	88	31	virus	virus	NN
cord-295559-yc8q62z8	88	32	,	,	,
cord-295559-yc8q62z8	88	33	human	human	JJ
cord-295559-yc8q62z8	88	34	metapneumovirus	metapneumovirus	NNP
cord-295559-yc8q62z8	88	35	and	and	CC
cord-295559-yc8q62z8	88	36	SARS	SARS	NNP
cord-295559-yc8q62z8	88	37	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	88	38	in	in	IN
cord-295559-yc8q62z8	88	39	group	group	NN
cord-295559-yc8q62z8	88	40	b	b	NNP
cord-295559-yc8q62z8	88	41	[	[	-LRB-
cord-295559-yc8q62z8	88	42	19	19	CD
cord-295559-yc8q62z8	88	43	,	,	,
cord-295559-yc8q62z8	88	44	20	20	CD
cord-295559-yc8q62z8	88	45	,	,	,
cord-295559-yc8q62z8	88	46	[	[	-LRB-
cord-295559-yc8q62z8	88	47	42	42	CD
cord-295559-yc8q62z8	88	48	]	]	-RRB-
cord-295559-yc8q62z8	89	1	[	[	-LRB-
cord-295559-yc8q62z8	89	2	43	43	CD
cord-295559-yc8q62z8	89	3	]	]	-RRB-
cord-295559-yc8q62z8	89	4	[	[	-LRB-
cord-295559-yc8q62z8	89	5	44	44	CD
cord-295559-yc8q62z8	89	6	]	]	-RRB-
cord-295559-yc8q62z8	89	7	[	[	-LRB-
cord-295559-yc8q62z8	89	8	45	45	CD
cord-295559-yc8q62z8	89	9	]	]	-RRB-
cord-295559-yc8q62z8	89	10	.	.	.
cord-295559-yc8q62z8	90	1	We	-PRON-	PRP
cord-295559-yc8q62z8	90	2	therefore	therefore	RB
cord-295559-yc8q62z8	90	3	transfected	transfecte	VBD
cord-295559-yc8q62z8	90	4	293	293	CD
cord-295559-yc8q62z8	90	5	T	t	NN
cord-295559-yc8q62z8	90	6	cells	cell	NNS
cord-295559-yc8q62z8	90	7	with	with	IN
cord-295559-yc8q62z8	90	8	plasmids	plasmid	NNS
cord-295559-yc8q62z8	90	9	encoding	encode	VBG
cord-295559-yc8q62z8	90	10	TMPRSS-2	tmprss-2	ADD
cord-295559-yc8q62z8	90	11	or	or	CC
cord-295559-yc8q62z8	90	12	-4	-4	NNP
cord-295559-yc8q62z8	90	13	,	,	,
cord-295559-yc8q62z8	90	14	MERS	MERS	NNP
cord-295559-yc8q62z8	90	15	-	-	HYPH
cord-295559-yc8q62z8	90	16	CoV	cov	NN
cord-295559-yc8q62z8	90	17	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	90	18	protein	protein	NN
cord-295559-yc8q62z8	90	19	,	,	,
cord-295559-yc8q62z8	90	20	psPAX2	psPAX2	NNP
cord-295559-yc8q62z8	90	21	and	and	CC
cord-295559-yc8q62z8	90	22	pLenti	pLenti	NNP
cord-295559-yc8q62z8	90	23	-	-	HYPH
cord-295559-yc8q62z8	90	24	GFP	GFP	NNP
cord-295559-yc8q62z8	90	25	-	-	HYPH
cord-295559-yc8q62z8	90	26	Luc	Luc	NNP
cord-295559-yc8q62z8	90	27	and	and	CC
cord-295559-yc8q62z8	90	28	investigated	investigate	VBD
cord-295559-yc8q62z8	90	29	whether	whether	IN
cord-295559-yc8q62z8	90	30	S	S	NNP
cord-295559-yc8q62z8	90	31	proteins	protein	NNS
cord-295559-yc8q62z8	90	32	on	on	IN
cord-295559-yc8q62z8	90	33	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	90	34	produced	produce	VBN
cord-295559-yc8q62z8	90	35	in	in	IN
cord-295559-yc8q62z8	90	36	these	these	DT
cord-295559-yc8q62z8	90	37	cells	cell	NNS
cord-295559-yc8q62z8	90	38	were	be	VBD
cord-295559-yc8q62z8	90	39	cleaved	cleave	VBN
cord-295559-yc8q62z8	90	40	and	and	CC
cord-295559-yc8q62z8	90	41	whether	whether	IN
cord-295559-yc8q62z8	90	42	they	-PRON-	PRP
cord-295559-yc8q62z8	90	43	could	could	MD
cord-295559-yc8q62z8	90	44	infect	infect	VB
cord-295559-yc8q62z8	90	45	Vero	Vero	NNP
cord-295559-yc8q62z8	90	46	E6	E6	NNP
cord-295559-yc8q62z8	90	47	cells	cell	NNS
cord-295559-yc8q62z8	90	48	in	in	IN
cord-295559-yc8q62z8	90	49	the	the	DT
cord-295559-yc8q62z8	90	50	presence	presence	NN
cord-295559-yc8q62z8	90	51	of	of	IN
cord-295559-yc8q62z8	90	52	NH	NH	NNP
cord-295559-yc8q62z8	90	53	4	4	CD
cord-295559-yc8q62z8	90	54	Cl	Cl	NNP
cord-295559-yc8q62z8	90	55	.	.	.
cord-295559-yc8q62z8	91	1	Surprisingly	surprisingly	RB
cord-295559-yc8q62z8	91	2	,	,	,
cord-295559-yc8q62z8	91	3	the	the	DT
cord-295559-yc8q62z8	91	4	pseudovirionproducing	pseudovirionproduce	VBG
cord-295559-yc8q62z8	91	5	293	293	CD
cord-295559-yc8q62z8	91	6	T	T	NNP
cord-295559-yc8q62z8	91	7	cells	cell	NNS
cord-295559-yc8q62z8	91	8	expressing	express	VBG
cord-295559-yc8q62z8	91	9	either	either	CC
cord-295559-yc8q62z8	91	10	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	91	11	or	or	CC
cord-295559-yc8q62z8	91	12	-4	-4	NNP
cord-295559-yc8q62z8	91	13	,	,	,
cord-295559-yc8q62z8	91	14	formed	form	VBD
cord-295559-yc8q62z8	91	15	large	large	JJ
cord-295559-yc8q62z8	91	16	syncytia	syncytia	NN
cord-295559-yc8q62z8	91	17	by	by	IN
cord-295559-yc8q62z8	91	18	40	40	CD
cord-295559-yc8q62z8	91	19	hrs	hrs	NN
cord-295559-yc8q62z8	91	20	after	after	IN
cord-295559-yc8q62z8	91	21	transfection	transfection	NN
cord-295559-yc8q62z8	91	22	(	(	-LRB-
cord-295559-yc8q62z8	91	23	Figure	figure	NN
cord-295559-yc8q62z8	91	24	5A	5a	NN
cord-295559-yc8q62z8	91	25	)	)	-RRB-
cord-295559-yc8q62z8	91	26	,	,	,
cord-295559-yc8q62z8	91	27	but	but	CC
cord-295559-yc8q62z8	91	28	the	the	DT
cord-295559-yc8q62z8	91	29	MERS	MERS	NNP
cord-295559-yc8q62z8	91	30	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	91	31	produced	produce	VBN
cord-295559-yc8q62z8	91	32	by	by	IN
cord-295559-yc8q62z8	91	33	these	these	DT
cord-295559-yc8q62z8	91	34	cells	cell	NNS
cord-295559-yc8q62z8	91	35	could	could	MD
cord-295559-yc8q62z8	91	36	not	not	RB
cord-295559-yc8q62z8	91	37	transduce	transduce	VB
cord-295559-yc8q62z8	91	38	Vero	Vero	NNP
cord-295559-yc8q62z8	91	39	E6	E6	NNP
cord-295559-yc8q62z8	91	40	cells	cell	NNS
cord-295559-yc8q62z8	91	41	in	in	IN
cord-295559-yc8q62z8	91	42	the	the	DT
cord-295559-yc8q62z8	91	43	presence	presence	NN
cord-295559-yc8q62z8	91	44	or	or	CC
cord-295559-yc8q62z8	91	45	absence	absence	NN
cord-295559-yc8q62z8	91	46	of	of	IN
cord-295559-yc8q62z8	91	47	NH	NH	NNP
cord-295559-yc8q62z8	91	48	4	4	CD
cord-295559-yc8q62z8	91	49	Cl	Cl	NNP
cord-295559-yc8q62z8	91	50	(	(	-LRB-
cord-295559-yc8q62z8	91	51	Figure	figure	NN
cord-295559-yc8q62z8	91	52	5B	5b	NN
cord-295559-yc8q62z8	91	53	)	)	-RRB-
cord-295559-yc8q62z8	91	54	.	.	.
cord-295559-yc8q62z8	92	1	In	in	IN
cord-295559-yc8q62z8	92	2	contrast	contrast	NN
cord-295559-yc8q62z8	92	3	,	,	,
cord-295559-yc8q62z8	92	4	without	without	IN
cord-295559-yc8q62z8	92	5	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	92	6	or	or	CC
cord-295559-yc8q62z8	92	7	-4	-4	NNP
cord-295559-yc8q62z8	92	8	,	,	,
cord-295559-yc8q62z8	92	9	the	the	DT
cord-295559-yc8q62z8	92	10	293	293	CD
cord-295559-yc8q62z8	92	11	T	T	NNP
cord-295559-yc8q62z8	92	12	cells	cell	NNS
cord-295559-yc8q62z8	92	13	expressing	express	VBG
cord-295559-yc8q62z8	92	14	uncleaved	uncleave	VBN
cord-295559-yc8q62z8	92	15	MERS	MERS	NNP
cord-295559-yc8q62z8	92	16	-	-	HYPH
cord-295559-yc8q62z8	92	17	CoV	cov	NN
cord-295559-yc8q62z8	92	18	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	92	19	did	do	VBD
cord-295559-yc8q62z8	92	20	not	not	RB
cord-295559-yc8q62z8	92	21	form	form	VB
cord-295559-yc8q62z8	92	22	syncytia	syncytia	NN
cord-295559-yc8q62z8	92	23	,	,	,
cord-295559-yc8q62z8	92	24	and	and	CC
cord-295559-yc8q62z8	92	25	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	92	26	that	that	IN
cord-295559-yc8q62z8	92	27	they	-PRON-	PRP
cord-295559-yc8q62z8	92	28	produced	produce	VBD
cord-295559-yc8q62z8	92	29	efficiently	efficiently	RB
cord-295559-yc8q62z8	92	30	infected	infect	VBN
cord-295559-yc8q62z8	92	31	Vero	Vero	NNP
cord-295559-yc8q62z8	92	32	E6	E6	NNP
cord-295559-yc8q62z8	92	33	cells	cell	NNS
cord-295559-yc8q62z8	92	34	,	,	,
cord-295559-yc8q62z8	92	35	but	but	CC
cord-295559-yc8q62z8	92	36	virus	virus	NN
cord-295559-yc8q62z8	92	37	entry	entry	NN
cord-295559-yc8q62z8	92	38	was	be	VBD
cord-295559-yc8q62z8	92	39	inhibited	inhibit	VBN
cord-295559-yc8q62z8	92	40	by	by	IN
cord-295559-yc8q62z8	92	41	NH	NH	NNP
cord-295559-yc8q62z8	92	42	4	4	CD
cord-295559-yc8q62z8	92	43	Cl	Cl	NNP
cord-295559-yc8q62z8	92	44	(	(	-LRB-
cord-295559-yc8q62z8	92	45	Figure	figure	NN
cord-295559-yc8q62z8	92	46	5B	5b	NN
cord-295559-yc8q62z8	92	47	)	)	-RRB-
cord-295559-yc8q62z8	92	48	.	.	.
cord-295559-yc8q62z8	93	1	Immunoblots	Immunoblots	NNP
cord-295559-yc8q62z8	93	2	with	with	IN
cord-295559-yc8q62z8	93	3	antibody	antibody	NN
cord-295559-yc8q62z8	93	4	AO4	ao4	NN
cord-295559-yc8q62z8	93	5	to	to	IN
cord-295559-yc8q62z8	93	6	MHV	MHV	NNP
cord-295559-yc8q62z8	93	7	S	S	NNP
cord-295559-yc8q62z8	93	8	or	or	CC
cord-295559-yc8q62z8	93	9	anti	anti	JJ
cord-295559-yc8q62z8	93	10	-	-	JJ
cord-295559-yc8q62z8	93	11	FLAG	flag	JJ
cord-295559-yc8q62z8	93	12	(	(	-LRB-
cord-295559-yc8q62z8	93	13	data	datum	NNS
cord-295559-yc8q62z8	93	14	not	not	RB
cord-295559-yc8q62z8	93	15	shown	show	VBN
cord-295559-yc8q62z8	93	16	)	)	-RRB-
cord-295559-yc8q62z8	93	17	revealed	reveal	VBD
cord-295559-yc8q62z8	93	18	that	that	IN
cord-295559-yc8q62z8	93	19	the	the	DT
cord-295559-yc8q62z8	93	20	MERS	MERS	NNP
cord-295559-yc8q62z8	93	21	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	93	22	produced	produce	VBN
cord-295559-yc8q62z8	93	23	in	in	IN
cord-295559-yc8q62z8	93	24	293	293	CD
cord-295559-yc8q62z8	93	25	T	t	NN
cord-295559-yc8q62z8	93	26	cells	cell	NNS
cord-295559-yc8q62z8	93	27	expressing	express	VBG
cord-295559-yc8q62z8	93	28	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	93	29	or	or	CC
cord-295559-yc8q62z8	93	30	-4	-4	NNP
cord-295559-yc8q62z8	93	31	contained	contain	VBD
cord-295559-yc8q62z8	93	32	little	little	JJ
cord-295559-yc8q62z8	93	33	or	or	CC
cord-295559-yc8q62z8	93	34	no	no	DT
cord-295559-yc8q62z8	93	35	immunoreactive	immunoreactive	JJ
cord-295559-yc8q62z8	93	36	S	S	NNP
cord-295559-yc8q62z8	93	37	protein	protein	NN
cord-295559-yc8q62z8	93	38	or	or	CC
cord-295559-yc8q62z8	93	39	fragments	fragment	NNS
cord-295559-yc8q62z8	93	40	of	of	IN
cord-295559-yc8q62z8	93	41	S.	S.	NNP
cord-295559-yc8q62z8	94	1	Although	although	IN
cord-295559-yc8q62z8	94	2	the	the	DT
cord-295559-yc8q62z8	94	3	novel	novel	JJ
cord-295559-yc8q62z8	94	4	group	group	NN
cord-295559-yc8q62z8	94	5	c	c	NNP
cord-295559-yc8q62z8	94	6	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	94	7	MERS	MERS	NNP
cord-295559-yc8q62z8	94	8	-	-	HYPH
cord-295559-yc8q62z8	94	9	CoV	CoV	NNP
cord-295559-yc8q62z8	94	10	is	be	VBZ
cord-295559-yc8q62z8	94	11	highly	highly	RB
cord-295559-yc8q62z8	94	12	virulent	virulent	JJ
cord-295559-yc8q62z8	94	13	in	in	IN
cord-295559-yc8q62z8	94	14	humans	human	NNS
cord-295559-yc8q62z8	94	15	and	and	CC
cord-295559-yc8q62z8	94	16	can	can	MD
cord-295559-yc8q62z8	94	17	infect	infect	VB
cord-295559-yc8q62z8	94	18	cells	cell	NNS
cord-295559-yc8q62z8	94	19	from	from	IN
cord-295559-yc8q62z8	94	20	several	several	JJ
cord-295559-yc8q62z8	94	21	different	different	JJ
cord-295559-yc8q62z8	94	22	species	specie	NNS
cord-295559-yc8q62z8	94	23	,	,	,
cord-295559-yc8q62z8	94	24	including	include	VBG
cord-295559-yc8q62z8	94	25	humans	human	NNS
cord-295559-yc8q62z8	94	26	,	,	,
cord-295559-yc8q62z8	94	27	monkeys	monkey	NNS
cord-295559-yc8q62z8	94	28	,	,	,
cord-295559-yc8q62z8	94	29	pigs	pig	NNS
cord-295559-yc8q62z8	94	30	,	,	,
cord-295559-yc8q62z8	94	31	and	and	CC
cord-295559-yc8q62z8	94	32	some	some	DT
cord-295559-yc8q62z8	94	33	species	specie	NNS
cord-295559-yc8q62z8	94	34	of	of	IN
cord-295559-yc8q62z8	94	35	bats	bat	NNS
cord-295559-yc8q62z8	94	36	[	[	-LRB-
cord-295559-yc8q62z8	94	37	10	10	CD
cord-295559-yc8q62z8	94	38	,	,	,
cord-295559-yc8q62z8	94	39	16	16	CD
cord-295559-yc8q62z8	94	40	,	,	,
cord-295559-yc8q62z8	94	41	34	34	CD
cord-295559-yc8q62z8	94	42	]	]	-RRB-
cord-295559-yc8q62z8	94	43	,	,	,
cord-295559-yc8q62z8	94	44	little	little	JJ
cord-295559-yc8q62z8	94	45	is	be	VBZ
cord-295559-yc8q62z8	94	46	known	know	VBN
cord-295559-yc8q62z8	94	47	about	about	IN
cord-295559-yc8q62z8	94	48	the	the	DT
cord-295559-yc8q62z8	94	49	biology	biology	NN
cord-295559-yc8q62z8	94	50	of	of	IN
cord-295559-yc8q62z8	94	51	this	this	DT
cord-295559-yc8q62z8	94	52	virus	virus	NN
cord-295559-yc8q62z8	94	53	.	.	.
cord-295559-yc8q62z8	95	1	Because	because	IN
cord-295559-yc8q62z8	95	2	the	the	DT
cord-295559-yc8q62z8	95	3	spike	spike	NN
cord-295559-yc8q62z8	95	4	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	95	5	is	be	VBZ
cord-295559-yc8q62z8	95	6	essential	essential	JJ
cord-295559-yc8q62z8	95	7	for	for	IN
cord-295559-yc8q62z8	95	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	95	9	entry	entry	NN
cord-295559-yc8q62z8	95	10	,	,	,
cord-295559-yc8q62z8	95	11	elucidating	elucidate	VBG
cord-295559-yc8q62z8	95	12	the	the	DT
cord-295559-yc8q62z8	95	13	functions	function	NNS
cord-295559-yc8q62z8	95	14	of	of	IN
cord-295559-yc8q62z8	95	15	the	the	DT
cord-295559-yc8q62z8	95	16	MERS	MERS	NNP
cord-295559-yc8q62z8	95	17	-	-	HYPH
cord-295559-yc8q62z8	95	18	CoV	cov	NN
cord-295559-yc8q62z8	95	19	spike	spike	NN
cord-295559-yc8q62z8	95	20	can	can	MD
cord-295559-yc8q62z8	95	21	provide	provide	VB
cord-295559-yc8q62z8	95	22	valuable	valuable	JJ
cord-295559-yc8q62z8	95	23	insight	insight	NN
cord-295559-yc8q62z8	95	24	into	into	IN
cord-295559-yc8q62z8	95	25	the	the	DT
cord-295559-yc8q62z8	95	26	pathogenesis	pathogenesis	NN
cord-295559-yc8q62z8	95	27	of	of	IN
cord-295559-yc8q62z8	95	28	MERS	MERS	NNP
cord-295559-yc8q62z8	95	29	-	-	HYPH
cord-295559-yc8q62z8	95	30	CoV	CoV	NNP
cord-295559-yc8q62z8	95	31	,	,	,
cord-295559-yc8q62z8	95	32	and	and	CC
cord-295559-yc8q62z8	95	33	suggest	suggest	VBP
cord-295559-yc8q62z8	95	34	potential	potential	JJ
cord-295559-yc8q62z8	95	35	therapeutic	therapeutic	JJ
cord-295559-yc8q62z8	95	36	interventions	intervention	NNS
cord-295559-yc8q62z8	95	37	.	.	.
cord-295559-yc8q62z8	96	1	Here	here	RB
cord-295559-yc8q62z8	96	2	we	-PRON-	PRP
cord-295559-yc8q62z8	96	3	used	use	VBD
cord-295559-yc8q62z8	96	4	lentivirus	lentivirus	NN
cord-295559-yc8q62z8	96	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	96	6	with	with	IN
cord-295559-yc8q62z8	96	7	MERS	MERS	NNP
cord-295559-yc8q62z8	96	8	-	-	HYPH
cord-295559-yc8q62z8	96	9	CoV	CoV	NNP
cord-295559-yc8q62z8	96	10	spike	spike	NN
cord-295559-yc8q62z8	96	11	protein	protein	NN
cord-295559-yc8q62z8	96	12	to	to	TO
cord-295559-yc8q62z8	96	13	study	study	VB
cord-295559-yc8q62z8	96	14	S	S	NNP
cord-295559-yc8q62z8	96	15	-	-	HYPH
cord-295559-yc8q62z8	96	16	mediated	mediate	VBN
cord-295559-yc8q62z8	96	17	cell	cell	NN
cord-295559-yc8q62z8	96	18	entry	entry	NN
cord-295559-yc8q62z8	96	19	at	at	IN
cord-295559-yc8q62z8	96	20	Biosafety	Biosafety	NNP
cord-295559-yc8q62z8	96	21	Level	Level	NNP
cord-295559-yc8q62z8	96	22	2	2	CD
cord-295559-yc8q62z8	96	23	.	.	.
cord-295559-yc8q62z8	97	1	We	-PRON-	PRP
cord-295559-yc8q62z8	97	2	found	find	VBD
cord-295559-yc8q62z8	97	3	that	that	IN
cord-295559-yc8q62z8	97	4	MERS	MERS	NNP
cord-295559-yc8q62z8	97	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	97	6	,	,	,
cord-295559-yc8q62z8	97	7	like	like	IN
cord-295559-yc8q62z8	97	8	infectious	infectious	JJ
cord-295559-yc8q62z8	97	9	MERS	MERS	NNP
cord-295559-yc8q62z8	97	10	-	-	HYPH
cord-295559-yc8q62z8	97	11	CoV	CoV	NNP
cord-295559-yc8q62z8	97	12	virions	virion	NNS
cord-295559-yc8q62z8	97	13	[	[	-LRB-
cord-295559-yc8q62z8	97	14	10	10	CD
cord-295559-yc8q62z8	97	15	,	,	,
cord-295559-yc8q62z8	97	16	34	34	CD
cord-295559-yc8q62z8	97	17	]	]	-RRB-
cord-295559-yc8q62z8	97	18	,	,	,
cord-295559-yc8q62z8	97	19	readily	readily	RB
cord-295559-yc8q62z8	97	20	infected	infect	VBD
cord-295559-yc8q62z8	97	21	the	the	DT
cord-295559-yc8q62z8	97	22	Vero	Vero	NNP
cord-295559-yc8q62z8	97	23	E6	E6	NNP
cord-295559-yc8q62z8	97	24	and	and	CC
cord-295559-yc8q62z8	97	25	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	97	26	lines	line	NNS
cord-295559-yc8q62z8	97	27	of	of	IN
cord-295559-yc8q62z8	97	28	monkey	monkey	NN
cord-295559-yc8q62z8	97	29	kidney	kidney	NN
cord-295559-yc8q62z8	97	30	cells	cell	NNS
cord-295559-yc8q62z8	97	31	,	,	,
cord-295559-yc8q62z8	97	32	several	several	JJ
cord-295559-yc8q62z8	97	33	human	human	JJ
cord-295559-yc8q62z8	97	34	respiratory	respiratory	JJ
cord-295559-yc8q62z8	97	35	epithelial	epithelial	JJ
cord-295559-yc8q62z8	97	36	cell	cell	NN
cord-295559-yc8q62z8	97	37	lines	line	NNS
cord-295559-yc8q62z8	97	38	,	,	,
cord-295559-yc8q62z8	97	39	and	and	CC
cord-295559-yc8q62z8	97	40	embryo	embryo	NN
cord-295559-yc8q62z8	97	41	cells	cell	NNS
cord-295559-yc8q62z8	97	42	from	from	IN
cord-295559-yc8q62z8	97	43	Eptesicus	Eptesicus	NNP
cord-295559-yc8q62z8	97	44	fuscus	fuscus	NN
cord-295559-yc8q62z8	97	45	bats	bat	NNS
cord-295559-yc8q62z8	97	46	.	.	.
cord-295559-yc8q62z8	98	1	Others	other	NNS
cord-295559-yc8q62z8	98	2	have	have	VBP
cord-295559-yc8q62z8	98	3	also	also	RB
cord-295559-yc8q62z8	98	4	recently	recently	RB
cord-295559-yc8q62z8	98	5	demonstrated	demonstrate	VBN
cord-295559-yc8q62z8	98	6	that	that	IN
cord-295559-yc8q62z8	98	7	human	human	JJ
cord-295559-yc8q62z8	98	8	respiratory	respiratory	JJ
cord-295559-yc8q62z8	98	9	tract	tract	NN
cord-295559-yc8q62z8	98	10	cells	cell	NNS
cord-295559-yc8q62z8	98	11	,	,	,
cord-295559-yc8q62z8	98	12	and	and	CC
cord-295559-yc8q62z8	98	13	also	also	RB
cord-295559-yc8q62z8	98	14	primary	primary	JJ
cord-295559-yc8q62z8	98	15	human	human	JJ
cord-295559-yc8q62z8	98	16	bronchus	bronchus	NN
cord-295559-yc8q62z8	98	17	and	and	CC
cord-295559-yc8q62z8	98	18	alveolar	alveolar	NN
cord-295559-yc8q62z8	98	19	cells	cell	NNS
cord-295559-yc8q62z8	98	20	are	be	VBP
cord-295559-yc8q62z8	98	21	susceptible	susceptible	JJ
cord-295559-yc8q62z8	98	22	to	to	IN
cord-295559-yc8q62z8	98	23	MERS	MERS	NNP
cord-295559-yc8q62z8	98	24	-	-	HYPH
cord-295559-yc8q62z8	98	25	CoV	CoV	NNP
cord-295559-yc8q62z8	98	26	in	in	IN
cord-295559-yc8q62z8	98	27	accord	accord	NN
cord-295559-yc8q62z8	98	28	with	with	IN
cord-295559-yc8q62z8	98	29	the	the	DT
cord-295559-yc8q62z8	98	30	severe	severe	JJ
cord-295559-yc8q62z8	98	31	respiratory	respiratory	JJ
cord-295559-yc8q62z8	98	32	disease	disease	NN
cord-295559-yc8q62z8	98	33	in	in	IN
cord-295559-yc8q62z8	98	34	MERS	MERS	NNP
cord-295559-yc8q62z8	98	35	patients	patient	NNS
cord-295559-yc8q62z8	98	36	[	[	-LRB-
cord-295559-yc8q62z8	98	37	10	10	CD
cord-295559-yc8q62z8	98	38	,	,	,
cord-295559-yc8q62z8	98	39	33	33	CD
cord-295559-yc8q62z8	98	40	,	,	,
cord-295559-yc8q62z8	98	41	35	35	CD
cord-295559-yc8q62z8	98	42	,	,	,
cord-295559-yc8q62z8	98	43	46	46	CD
cord-295559-yc8q62z8	98	44	]	]	-RRB-
cord-295559-yc8q62z8	98	45	.	.	.
cord-295559-yc8q62z8	99	1	Muller	Muller	NNP
cord-295559-yc8q62z8	99	2	et	et	NNP
cord-295559-yc8q62z8	99	3	al	al	NNP
cord-295559-yc8q62z8	99	4	.	.	.
cord-295559-yc8q62z8	100	1	[	[	-LRB-
cord-295559-yc8q62z8	100	2	34	34	CD
cord-295559-yc8q62z8	100	3	]	]	-RRB-
cord-295559-yc8q62z8	100	4	recently	recently	RB
cord-295559-yc8q62z8	100	5	reported	report	VBD
cord-295559-yc8q62z8	100	6	that	that	IN
cord-295559-yc8q62z8	100	7	MERS	MERS	NNP
cord-295559-yc8q62z8	100	8	-	-	HYPH
cord-295559-yc8q62z8	100	9	CoV	CoV	NNP
cord-295559-yc8q62z8	100	10	can	can	MD
cord-295559-yc8q62z8	100	11	infect	infect	VB
cord-295559-yc8q62z8	100	12	cells	cell	NNS
cord-295559-yc8q62z8	100	13	from	from	IN
cord-295559-yc8q62z8	100	14	four	four	CD
cord-295559-yc8q62z8	100	15	genera	genus	NNS
cord-295559-yc8q62z8	100	16	of	of	IN
cord-295559-yc8q62z8	100	17	Old	old	JJ
cord-295559-yc8q62z8	100	18	World	World	NNP
cord-295559-yc8q62z8	100	19	bats	bat	NNS
cord-295559-yc8q62z8	100	20	,	,	,
cord-295559-yc8q62z8	100	21	Rousettus	Rousettus	NNP
cord-295559-yc8q62z8	100	22	,	,	,
cord-295559-yc8q62z8	100	23	Rhinolophus	Rhinolophus	NNP
cord-295559-yc8q62z8	100	24	,	,	,
cord-295559-yc8q62z8	100	25	Pipistrellus	Pipistrellus	NNP
cord-295559-yc8q62z8	100	26	,	,	,
cord-295559-yc8q62z8	100	27	and	and	CC
cord-295559-yc8q62z8	100	28	Myotis	Myotis	NNP
cord-295559-yc8q62z8	100	29	,	,	,
cord-295559-yc8q62z8	100	30	and	and	CC
cord-295559-yc8q62z8	100	31	one	one	CD
cord-295559-yc8q62z8	100	32	New	new	JJ
cord-295559-yc8q62z8	100	33	World	World	NNP
cord-295559-yc8q62z8	100	34	genus	genus	NN
cord-295559-yc8q62z8	100	35	,	,	,
cord-295559-yc8q62z8	100	36	Carollia	Carollia	NNP
cord-295559-yc8q62z8	100	37	.	.	.
cord-295559-yc8q62z8	101	1	We	-PRON-	PRP
cord-295559-yc8q62z8	101	2	found	find	VBD
cord-295559-yc8q62z8	101	3	that	that	IN
cord-295559-yc8q62z8	101	4	MERS	MERS	NNP
cord-295559-yc8q62z8	101	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	101	6	could	could	MD
cord-295559-yc8q62z8	101	7	also	also	RB
cord-295559-yc8q62z8	101	8	infect	infect	VB
cord-295559-yc8q62z8	101	9	cells	cell	NNS
cord-295559-yc8q62z8	101	10	from	from	IN
cord-295559-yc8q62z8	101	11	one	one	CD
cord-295559-yc8q62z8	101	12	New	New	NNP
cord-295559-yc8q62z8	101	13	World	World	NNP
cord-295559-yc8q62z8	101	14	bat	bat	NN
cord-295559-yc8q62z8	101	15	,	,	,
cord-295559-yc8q62z8	101	16	E.	E.	NNP
cord-295559-yc8q62z8	101	17	fuscus	fuscus	NN
cord-295559-yc8q62z8	101	18	,	,	,
cord-295559-yc8q62z8	101	19	but	but	CC
cord-295559-yc8q62z8	101	20	not	not	RB
cord-295559-yc8q62z8	101	21	from	from	IN
cord-295559-yc8q62z8	101	22	another	another	DT
cord-295559-yc8q62z8	101	23	,	,	,
cord-295559-yc8q62z8	101	24	T.	t.	NN
cord-295559-yc8q62z8	101	25	brasiliensis	brasiliensis	NN
cord-295559-yc8q62z8	101	26	.	.	.
cord-295559-yc8q62z8	102	1	The	the	DT
cord-295559-yc8q62z8	102	2	ability	ability	NN
cord-295559-yc8q62z8	102	3	of	of	IN
cord-295559-yc8q62z8	102	4	MERS	MERS	NNP
cord-295559-yc8q62z8	102	5	-	-	HYPH
cord-295559-yc8q62z8	102	6	CoV	CoV	NNP
cord-295559-yc8q62z8	102	7	to	to	TO
cord-295559-yc8q62z8	102	8	infect	infect	VB
cord-295559-yc8q62z8	102	9	cells	cell	NNS
cord-295559-yc8q62z8	102	10	from	from	IN
cord-295559-yc8q62z8	102	11	multiple	multiple	JJ
cord-295559-yc8q62z8	102	12	mammalian	mammalian	JJ
cord-295559-yc8q62z8	102	13	species	specie	NNS
cord-295559-yc8q62z8	102	14	directly	directly	RB
cord-295559-yc8q62z8	102	15	and	and	CC
cord-295559-yc8q62z8	102	16	without	without	IN
cord-295559-yc8q62z8	102	17	adaptation	adaptation	NN
cord-295559-yc8q62z8	102	18	[	[	-LRB-
cord-295559-yc8q62z8	102	19	47	47	CD
cord-295559-yc8q62z8	102	20	]	]	-RRB-
cord-295559-yc8q62z8	102	21	,	,	,
cord-295559-yc8q62z8	102	22	including	include	VBG
cord-295559-yc8q62z8	102	23	a	a	DT
cord-295559-yc8q62z8	102	24	diverse	diverse	JJ
cord-295559-yc8q62z8	102	25	array	array	NN
cord-295559-yc8q62z8	102	26	of	of	IN
cord-295559-yc8q62z8	102	27	both	both	DT
cord-295559-yc8q62z8	102	28	Old	Old	NNP
cord-295559-yc8q62z8	102	29	World	World	NNP
cord-295559-yc8q62z8	102	30	and	and	CC
cord-295559-yc8q62z8	102	31	New	New	NNP
cord-295559-yc8q62z8	102	32	World	World	NNP
cord-295559-yc8q62z8	102	33	bats	bat	NNS
cord-295559-yc8q62z8	102	34	,	,	,
cord-295559-yc8q62z8	102	35	suggests	suggest	VBZ
cord-295559-yc8q62z8	102	36	that	that	IN
cord-295559-yc8q62z8	102	37	the	the	DT
cord-295559-yc8q62z8	102	38	receptor	receptor	NN
cord-295559-yc8q62z8	102	39	for	for	IN
cord-295559-yc8q62z8	102	40	MERS	MERS	NNP
cord-295559-yc8q62z8	102	41	-	-	HYPH
cord-295559-yc8q62z8	102	42	CoV	CoV	NNP
cord-295559-yc8q62z8	102	43	,	,	,
cord-295559-yc8q62z8	102	44	DPP4	DPP4	NNP
cord-295559-yc8q62z8	102	45	[	[	-LRB-
cord-295559-yc8q62z8	102	46	28	28	CD
cord-295559-yc8q62z8	102	47	]	]	-RRB-
cord-295559-yc8q62z8	102	48	,	,	,
cord-295559-yc8q62z8	102	49	is	be	VBZ
cord-295559-yc8q62z8	102	50	broadly	broadly	RB
cord-295559-yc8q62z8	102	51	conserved	conserve	VBN
cord-295559-yc8q62z8	102	52	among	among	IN
cord-295559-yc8q62z8	102	53	many	many	JJ
cord-295559-yc8q62z8	102	54	species	specie	NNS
cord-295559-yc8q62z8	102	55	,	,	,
cord-295559-yc8q62z8	102	56	an	an	DT
cord-295559-yc8q62z8	102	57	important	important	JJ
cord-295559-yc8q62z8	102	58	property	property	NN
cord-295559-yc8q62z8	102	59	of	of	IN
cord-295559-yc8q62z8	102	60	many	many	JJ
cord-295559-yc8q62z8	102	61	emerging	emerge	VBG
cord-295559-yc8q62z8	102	62	viruses	virus	NNS
cord-295559-yc8q62z8	102	63	[	[	-LRB-
cord-295559-yc8q62z8	102	64	47	47	CD
cord-295559-yc8q62z8	102	65	,	,	,
cord-295559-yc8q62z8	102	66	48	48	CD
cord-295559-yc8q62z8	102	67	]	]	-RRB-
cord-295559-yc8q62z8	102	68	.	.	.
cord-295559-yc8q62z8	103	1	E.	E.	NNP
cord-295559-yc8q62z8	103	2	fuscus	fuscus	NN
cord-295559-yc8q62z8	103	3	Figure	figure	NN
cord-295559-yc8q62z8	103	4	5A	5a	NN
cord-295559-yc8q62z8	103	5	were	be	VBD
cord-295559-yc8q62z8	103	6	inoculated	inoculate	VBN
cord-295559-yc8q62z8	103	7	onto	onto	IN
cord-295559-yc8q62z8	103	8	Vero	Vero	NNP
cord-295559-yc8q62z8	103	9	E6	E6	NNP
cord-295559-yc8q62z8	103	10	cells	cell	NNS
cord-295559-yc8q62z8	103	11	in	in	IN
cord-295559-yc8q62z8	103	12	the	the	DT
cord-295559-yc8q62z8	103	13	presence	presence	NN
cord-295559-yc8q62z8	103	14	(	(	-LRB-
cord-295559-yc8q62z8	103	15	striped	striped	JJ
cord-295559-yc8q62z8	103	16	bars	bar	NNS
cord-295559-yc8q62z8	103	17	)	)	-RRB-
cord-295559-yc8q62z8	103	18	or	or	CC
cord-295559-yc8q62z8	103	19	absence	absence	NN
cord-295559-yc8q62z8	103	20	(	(	-LRB-
cord-295559-yc8q62z8	103	21	white	white	JJ
cord-295559-yc8q62z8	103	22	bars	bar	NNS
cord-295559-yc8q62z8	103	23	)	)	-RRB-
cord-295559-yc8q62z8	103	24	of	of	IN
cord-295559-yc8q62z8	103	25	20mM	20mm	CD
cord-295559-yc8q62z8	103	26	NH	NH	NNP
cord-295559-yc8q62z8	103	27	4	4	CD
cord-295559-yc8q62z8	103	28	Cl	Cl	NNP
cord-295559-yc8q62z8	103	29	to	to	TO
cord-295559-yc8q62z8	103	30	inhibit	inhibit	VB
cord-295559-yc8q62z8	103	31	acidification	acidification	NN
cord-295559-yc8q62z8	103	32	of	of	IN
cord-295559-yc8q62z8	103	33	endosomes	endosome	NNS
cord-295559-yc8q62z8	103	34	.	.	.
cord-295559-yc8q62z8	104	1	doi	doi	NNP
cord-295559-yc8q62z8	104	2	:	:	:
cord-295559-yc8q62z8	104	3	10.1371	10.1371	CD
cord-295559-yc8q62z8	104	4	/	/	SYM
cord-295559-yc8q62z8	104	5	journal.pone.0076469.g005	journal.pone.0076469.g005	NNP
cord-295559-yc8q62z8	104	6	bats	bat	NNS
cord-295559-yc8q62z8	104	7	,	,	,
cord-295559-yc8q62z8	104	8	commonly	commonly	RB
cord-295559-yc8q62z8	104	9	known	know	VBN
cord-295559-yc8q62z8	104	10	as	as	IN
cord-295559-yc8q62z8	104	11	big	big	JJ
cord-295559-yc8q62z8	104	12	brown	brown	JJ
cord-295559-yc8q62z8	104	13	bats	bat	NNS
cord-295559-yc8q62z8	104	14	,	,	,
cord-295559-yc8q62z8	104	15	are	be	VBP
cord-295559-yc8q62z8	104	16	the	the	DT
cord-295559-yc8q62z8	104	17	bats	bat	NNS
cord-295559-yc8q62z8	104	18	most	most	RBS
cord-295559-yc8q62z8	104	19	commonly	commonly	RB
cord-295559-yc8q62z8	104	20	encountered	encounter	VBN
cord-295559-yc8q62z8	104	21	by	by	IN
cord-295559-yc8q62z8	104	22	humans	human	NNS
cord-295559-yc8q62z8	104	23	in	in	IN
cord-295559-yc8q62z8	104	24	North	North	NNP
cord-295559-yc8q62z8	104	25	America	America	NNP
cord-295559-yc8q62z8	104	26	,	,	,
cord-295559-yc8q62z8	104	27	and	and	CC
cord-295559-yc8q62z8	104	28	they	-PRON-	PRP
cord-295559-yc8q62z8	104	29	are	be	VBP
cord-295559-yc8q62z8	104	30	a	a	DT
cord-295559-yc8q62z8	104	31	reservoir	reservoir	NN
cord-295559-yc8q62z8	104	32	for	for	IN
cord-295559-yc8q62z8	104	33	an	an	DT
cord-295559-yc8q62z8	104	34	alphacoronavirus	alphacoronavirus	NNP
cord-295559-yc8q62z8	104	35	[	[	-LRB-
cord-295559-yc8q62z8	104	36	49	49	CD
cord-295559-yc8q62z8	104	37	,	,	,
cord-295559-yc8q62z8	104	38	50	50	CD
cord-295559-yc8q62z8	104	39	]	]	-RRB-
cord-295559-yc8q62z8	104	40	.	.	.
cord-295559-yc8q62z8	105	1	It	-PRON-	PRP
cord-295559-yc8q62z8	105	2	will	will	MD
cord-295559-yc8q62z8	105	3	be	be	VB
cord-295559-yc8q62z8	105	4	important	important	JJ
cord-295559-yc8q62z8	105	5	to	to	TO
cord-295559-yc8q62z8	105	6	learn	learn	VB
cord-295559-yc8q62z8	105	7	whether	whether	IN
cord-295559-yc8q62z8	105	8	these	these	DT
cord-295559-yc8q62z8	105	9	New	New	NNP
cord-295559-yc8q62z8	105	10	World	World	NNP
cord-295559-yc8q62z8	105	11	bats	bat	NNS
cord-295559-yc8q62z8	105	12	are	be	VBP
cord-295559-yc8q62z8	105	13	susceptible	susceptible	JJ
cord-295559-yc8q62z8	105	14	to	to	IN
cord-295559-yc8q62z8	105	15	MERS	MERS	NNP
cord-295559-yc8q62z8	105	16	-	-	HYPH
cord-295559-yc8q62z8	105	17	CoV	CoV	NNP
cord-295559-yc8q62z8	105	18	or	or	CC
cord-295559-yc8q62z8	105	19	related	related	JJ
cord-295559-yc8q62z8	105	20	group	group	NN
cord-295559-yc8q62z8	105	21	c	c	NN
cord-295559-yc8q62z8	105	22	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	105	23	.	.	.
cord-295559-yc8q62z8	106	1	The	the	DT
cord-295559-yc8q62z8	106	2	recent	recent	JJ
cord-295559-yc8q62z8	106	3	detection	detection	NN
cord-295559-yc8q62z8	106	4	in	in	IN
cord-295559-yc8q62z8	106	5	N.	N.	NNP
cord-295559-yc8q62z8	106	6	laticaudatus	laticaudatus	NNP
cord-295559-yc8q62z8	106	7	bats	bat	NNS
cord-295559-yc8q62z8	106	8	in	in	IN
cord-295559-yc8q62z8	106	9	Mexico	Mexico	NNP
cord-295559-yc8q62z8	106	10	of	of	IN
cord-295559-yc8q62z8	106	11	a	a	DT
cord-295559-yc8q62z8	106	12	group	group	NN
cord-295559-yc8q62z8	106	13	c	c	NN
cord-295559-yc8q62z8	106	14	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	106	15	with	with	IN
cord-295559-yc8q62z8	106	16	96	96	CD
cord-295559-yc8q62z8	106	17	%	%	NN
cord-295559-yc8q62z8	106	18	similarity	similarity	NN
cord-295559-yc8q62z8	106	19	to	to	IN
cord-295559-yc8q62z8	106	20	MERS	MERS	NNP
cord-295559-yc8q62z8	106	21	-	-	HYPH
cord-295559-yc8q62z8	106	22	CoV	CoV	NNP
cord-295559-yc8q62z8	106	23	[	[	-LRB-
cord-295559-yc8q62z8	106	24	13	13	CD
cord-295559-yc8q62z8	106	25	]	]	-RRB-
cord-295559-yc8q62z8	106	26	,	,	,
cord-295559-yc8q62z8	106	27	coupled	couple	VBN
cord-295559-yc8q62z8	106	28	with	with	IN
cord-295559-yc8q62z8	106	29	the	the	DT
cord-295559-yc8q62z8	106	30	diverse	diverse	JJ
cord-295559-yc8q62z8	106	31	array	array	NN
cord-295559-yc8q62z8	106	32	of	of	IN
cord-295559-yc8q62z8	106	33	alphacoronaviruses	alphacoronaviruse	NNS
cord-295559-yc8q62z8	106	34	previously	previously	RB
cord-295559-yc8q62z8	106	35	discovered	discover	VBN
cord-295559-yc8q62z8	106	36	in	in	IN
cord-295559-yc8q62z8	106	37	North	north	JJ
cord-295559-yc8q62z8	106	38	American	american	JJ
cord-295559-yc8q62z8	106	39	bats	bat	NNS
cord-295559-yc8q62z8	106	40	[	[	-LRB-
cord-295559-yc8q62z8	106	41	49	49	CD
cord-295559-yc8q62z8	106	42	]	]	-RRB-
cord-295559-yc8q62z8	106	43	[	[	-LRB-
cord-295559-yc8q62z8	106	44	50	50	CD
cord-295559-yc8q62z8	106	45	]	]	-RRB-
cord-295559-yc8q62z8	106	46	[	[	-LRB-
cord-295559-yc8q62z8	106	47	51	51	CD
cord-295559-yc8q62z8	106	48	]	]	-RRB-
cord-295559-yc8q62z8	106	49	[	[	-LRB-
cord-295559-yc8q62z8	106	50	52	52	CD
cord-295559-yc8q62z8	106	51	]	]	-RRB-
cord-295559-yc8q62z8	106	52	,	,	,
cord-295559-yc8q62z8	106	53	justify	justify	VB
cord-295559-yc8q62z8	106	54	increased	increase	VBN
cord-295559-yc8q62z8	106	55	surveillance	surveillance	NN
cord-295559-yc8q62z8	106	56	to	to	TO
cord-295559-yc8q62z8	106	57	identify	identify	VB
cord-295559-yc8q62z8	106	58	additional	additional	JJ
cord-295559-yc8q62z8	106	59	species	specie	NNS
cord-295559-yc8q62z8	106	60	of	of	IN
cord-295559-yc8q62z8	106	61	New	new	JJ
cord-295559-yc8q62z8	106	62	World	World	NNP
cord-295559-yc8q62z8	106	63	bats	bat	NNS
cord-295559-yc8q62z8	106	64	that	that	WDT
cord-295559-yc8q62z8	106	65	may	may	MD
cord-295559-yc8q62z8	106	66	also	also	RB
cord-295559-yc8q62z8	106	67	harbor	harbor	VB
cord-295559-yc8q62z8	106	68	group	group	NN
cord-295559-yc8q62z8	106	69	c	c	NNP
cord-295559-yc8q62z8	106	70	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	106	71	like	like	IN
cord-295559-yc8q62z8	106	72	MERS	MERS	NNP
cord-295559-yc8q62z8	106	73	-	-	HYPH
cord-295559-yc8q62z8	106	74	CoV	CoV	NNP
cord-295559-yc8q62z8	106	75	or	or	CC
cord-295559-yc8q62z8	106	76	other	other	JJ
cord-295559-yc8q62z8	106	77	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	106	78	with	with	IN
cord-295559-yc8q62z8	106	79	the	the	DT
cord-295559-yc8q62z8	106	80	potential	potential	NN
cord-295559-yc8q62z8	106	81	to	to	TO
cord-295559-yc8q62z8	106	82	cause	cause	VB
cord-295559-yc8q62z8	106	83	severe	severe	JJ
cord-295559-yc8q62z8	106	84	disease	disease	NN
cord-295559-yc8q62z8	106	85	in	in	IN
cord-295559-yc8q62z8	106	86	humans	human	NNS
cord-295559-yc8q62z8	106	87	.	.	.
cord-295559-yc8q62z8	107	1	MERS	MERS	NNP
cord-295559-yc8q62z8	107	2	-	-	HYPH
cord-295559-yc8q62z8	107	3	CoV	CoV	NNP
cord-295559-yc8q62z8	107	4	is	be	VBZ
cord-295559-yc8q62z8	107	5	a	a	DT
cord-295559-yc8q62z8	107	6	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	107	7	in	in	IN
cord-295559-yc8q62z8	107	8	group	group	NN
cord-295559-yc8q62z8	107	9	c	c	NNP
cord-295559-yc8q62z8	107	10	,	,	,
cord-295559-yc8q62z8	107	11	and	and	CC
cord-295559-yc8q62z8	107	12	we	-PRON-	PRP
cord-295559-yc8q62z8	107	13	were	be	VBD
cord-295559-yc8q62z8	107	14	surprised	surprised	JJ
cord-295559-yc8q62z8	107	15	that	that	IN
cord-295559-yc8q62z8	107	16	its	-PRON-	PRP$
cord-295559-yc8q62z8	107	17	S	S	NNP
cord-295559-yc8q62z8	107	18	protein	protein	NN
cord-295559-yc8q62z8	107	19	was	be	VBD
cord-295559-yc8q62z8	107	20	recognized	recognize	VBN
cord-295559-yc8q62z8	107	21	in	in	IN
cord-295559-yc8q62z8	107	22	immunoblots	immunoblot	NNS
cord-295559-yc8q62z8	107	23	by	by	IN
cord-295559-yc8q62z8	107	24	a	a	DT
cord-295559-yc8q62z8	107	25	polyclonal	polyclonal	JJ
cord-295559-yc8q62z8	107	26	antibody	antibody	NN
cord-295559-yc8q62z8	107	27	to	to	IN
cord-295559-yc8q62z8	107	28	the	the	DT
cord-295559-yc8q62z8	107	29	spike	spike	NN
cord-295559-yc8q62z8	107	30	protein	protein	NN
cord-295559-yc8q62z8	107	31	of	of	IN
cord-295559-yc8q62z8	107	32	MHV	MHV	NNP
cord-295559-yc8q62z8	107	33	-	-	HYPH
cord-295559-yc8q62z8	107	34	A59	A59	NNP
cord-295559-yc8q62z8	107	35	,	,	,
cord-295559-yc8q62z8	107	36	a	a	DT
cord-295559-yc8q62z8	107	37	group	group	NN
cord-295559-yc8q62z8	107	38	a	a	DT
cord-295559-yc8q62z8	107	39	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	107	40	.	.	.
cord-295559-yc8q62z8	108	1	The	the	DT
cord-295559-yc8q62z8	108	2	cross	cross	JJ
cord-295559-yc8q62z8	108	3	-	-	JJ
cord-295559-yc8q62z8	108	4	reactive	reactive	JJ
cord-295559-yc8q62z8	108	5	epitope(s	epitope(s	NNP
cord-295559-yc8q62z8	108	6	)	)	-RRB-
cord-295559-yc8q62z8	108	7	was	be	VBD
cord-295559-yc8q62z8	108	8	mapped	map	VBN
cord-295559-yc8q62z8	108	9	to	to	IN
cord-295559-yc8q62z8	108	10	the	the	DT
cord-295559-yc8q62z8	108	11	S2	S2	NNP
cord-295559-yc8q62z8	108	12	domain	domain	NN
cord-295559-yc8q62z8	108	13	,	,	,
cord-295559-yc8q62z8	108	14	which	which	WDT
cord-295559-yc8q62z8	108	15	is	be	VBZ
cord-295559-yc8q62z8	108	16	more	more	RBR
cord-295559-yc8q62z8	108	17	highly	highly	RB
cord-295559-yc8q62z8	108	18	conserved	conserve	VBN
cord-295559-yc8q62z8	108	19	than	than	IN
cord-295559-yc8q62z8	108	20	the	the	DT
cord-295559-yc8q62z8	108	21	S1	S1	NNP
cord-295559-yc8q62z8	108	22	domain	domain	NN
cord-295559-yc8q62z8	108	23	of	of	IN
cord-295559-yc8q62z8	108	24	betacoronaviruses	betacoronaviruse	NNS
cord-295559-yc8q62z8	108	25	.	.	.
cord-295559-yc8q62z8	109	1	Chan	Chan	NNP
cord-295559-yc8q62z8	109	2	et	et	NNP
cord-295559-yc8q62z8	109	3	al	al	NNP
cord-295559-yc8q62z8	109	4	.	.	.
cord-295559-yc8q62z8	110	1	[	[	-LRB-
cord-295559-yc8q62z8	110	2	33	33	CD
cord-295559-yc8q62z8	110	3	,	,	,
cord-295559-yc8q62z8	110	4	53	53	CD
cord-295559-yc8q62z8	110	5	]	]	-RRB-
cord-295559-yc8q62z8	110	6	found	find	VBD
cord-295559-yc8q62z8	110	7	that	that	IN
cord-295559-yc8q62z8	110	8	MERS	MERS	NNP
cord-295559-yc8q62z8	110	9	-	-	HYPH
cord-295559-yc8q62z8	110	10	CoV	CoV	NNP
cord-295559-yc8q62z8	110	11	S	S	NNP
cord-295559-yc8q62z8	110	12	protein	protein	NN
cord-295559-yc8q62z8	110	13	was	be	VBD
cord-295559-yc8q62z8	110	14	recognized	recognize	VBN
cord-295559-yc8q62z8	110	15	in	in	IN
cord-295559-yc8q62z8	110	16	immunofluorescence	immunofluorescence	NN
cord-295559-yc8q62z8	110	17	and	and	CC
cord-295559-yc8q62z8	110	18	in	in	IN
cord-295559-yc8q62z8	110	19	vitro	vitro	FW
cord-295559-yc8q62z8	110	20	neutralization	neutralization	NN
cord-295559-yc8q62z8	110	21	assays	assay	NNS
cord-295559-yc8q62z8	110	22	by	by	IN
cord-295559-yc8q62z8	110	23	sera	sera	NNP
cord-295559-yc8q62z8	110	24	of	of	IN
cord-295559-yc8q62z8	110	25	some	some	DT
cord-295559-yc8q62z8	110	26	convalescent	convalescent	JJ
cord-295559-yc8q62z8	110	27	SARS	SARS	NNP
cord-295559-yc8q62z8	110	28	patients	patient	NNS
cord-295559-yc8q62z8	110	29	,	,	,
cord-295559-yc8q62z8	110	30	and	and	CC
cord-295559-yc8q62z8	110	31	suggested	suggest	VBD
cord-295559-yc8q62z8	110	32	,	,	,
cord-295559-yc8q62z8	110	33	based	base	VBN
cord-295559-yc8q62z8	110	34	on	on	IN
cord-295559-yc8q62z8	110	35	bioinformatics	bioinformatic	NNS
cord-295559-yc8q62z8	110	36	,	,	,
cord-295559-yc8q62z8	110	37	that	that	IN
cord-295559-yc8q62z8	110	38	epitope(s	epitope(s	NNP
cord-295559-yc8q62z8	110	39	)	)	-RRB-
cord-295559-yc8q62z8	110	40	in	in	IN
cord-295559-yc8q62z8	110	41	S2	S2	NNP
cord-295559-yc8q62z8	110	42	could	could	MD
cord-295559-yc8q62z8	110	43	account	account	VB
cord-295559-yc8q62z8	110	44	for	for	IN
cord-295559-yc8q62z8	110	45	the	the	DT
cord-295559-yc8q62z8	110	46	observed	observed	JJ
cord-295559-yc8q62z8	110	47	serological	serological	JJ
cord-295559-yc8q62z8	110	48	cross	cross	NN
cord-295559-yc8q62z8	110	49	-	-	NN
cord-295559-yc8q62z8	110	50	reactivity	reactivity	NN
cord-295559-yc8q62z8	110	51	.	.	.
cord-295559-yc8q62z8	111	1	These	these	DT
cord-295559-yc8q62z8	111	2	observations	observation	NNS
cord-295559-yc8q62z8	111	3	that	that	IN
cord-295559-yc8q62z8	111	4	the	the	DT
cord-295559-yc8q62z8	111	5	S	S	NNP
cord-295559-yc8q62z8	111	6	protein	protein	NN
cord-295559-yc8q62z8	111	7	of	of	IN
cord-295559-yc8q62z8	111	8	MERS	MERS	NNP
cord-295559-yc8q62z8	111	9	-	-	HYPH
cord-295559-yc8q62z8	111	10	CoV	CoV	NNP
cord-295559-yc8q62z8	111	11	,	,	,
cord-295559-yc8q62z8	111	12	a	a	DT
cord-295559-yc8q62z8	111	13	group	group	NN
cord-295559-yc8q62z8	111	14	c	c	NN
cord-295559-yc8q62z8	111	15	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	111	16	,	,	,
cord-295559-yc8q62z8	111	17	contains	contain	VBZ
cord-295559-yc8q62z8	111	18	crossreacting	crossreacte	VBG
cord-295559-yc8q62z8	111	19	epitope(s	epitope(s	NNP
cord-295559-yc8q62z8	111	20	)	)	-RRB-
cord-295559-yc8q62z8	111	21	with	with	IN
cord-295559-yc8q62z8	111	22	S	s	NN
cord-295559-yc8q62z8	111	23	proteins	protein	NNS
cord-295559-yc8q62z8	111	24	of	of	IN
cord-295559-yc8q62z8	111	25	both	both	CC
cord-295559-yc8q62z8	111	26	some	some	DT
cord-295559-yc8q62z8	111	27	group	group	NN
cord-295559-yc8q62z8	111	28	b	b	LS
cord-295559-yc8q62z8	111	29	(	(	-LRB-
cord-295559-yc8q62z8	111	30	SARS	SARS	NNP
cord-295559-yc8q62z8	111	31	-	-	HYPH
cord-295559-yc8q62z8	111	32	CoV	CoV	NNP
cord-295559-yc8q62z8	111	33	)	)	-RRB-
cord-295559-yc8q62z8	111	34	and	and	CC
cord-295559-yc8q62z8	111	35	group	group	NN
cord-295559-yc8q62z8	111	36	a	a	DT
cord-295559-yc8q62z8	111	37	(	(	-LRB-
cord-295559-yc8q62z8	111	38	MHV	MHV	NNP
cord-295559-yc8q62z8	111	39	)	)	-RRB-
cord-295559-yc8q62z8	111	40	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	111	41	,	,	,
cord-295559-yc8q62z8	111	42	indicate	indicate	VBP
cord-295559-yc8q62z8	111	43	that	that	IN
cord-295559-yc8q62z8	111	44	serological	serological	JJ
cord-295559-yc8q62z8	111	45	studies	study	NNS
cord-295559-yc8q62z8	111	46	may	may	MD
cord-295559-yc8q62z8	111	47	not	not	RB
cord-295559-yc8q62z8	111	48	accurately	accurately	RB
cord-295559-yc8q62z8	111	49	distinguish	distinguish	VB
cord-295559-yc8q62z8	111	50	between	between	IN
cord-295559-yc8q62z8	111	51	different	different	JJ
cord-295559-yc8q62z8	111	52	phylogenetic	phylogenetic	JJ
cord-295559-yc8q62z8	111	53	groups	group	NNS
cord-295559-yc8q62z8	111	54	of	of	IN
cord-295559-yc8q62z8	111	55	betacoronaviruses	betacoronaviruses	NNP
cord-295559-yc8q62z8	111	56	.	.	.
cord-295559-yc8q62z8	112	1	Identification	identification	NN
cord-295559-yc8q62z8	112	2	and	and	CC
cord-295559-yc8q62z8	112	3	characterization	characterization	NN
cord-295559-yc8q62z8	112	4	of	of	IN
cord-295559-yc8q62z8	112	5	the	the	DT
cord-295559-yc8q62z8	112	6	cross	cross	NN
cord-295559-yc8q62z8	112	7	-	-	JJ
cord-295559-yc8q62z8	112	8	reacting	reacting	JJ
cord-295559-yc8q62z8	112	9	epitope(s	epitope(s	NNP
cord-295559-yc8q62z8	112	10	)	)	-RRB-
cord-295559-yc8q62z8	112	11	is	be	VBZ
cord-295559-yc8q62z8	112	12	an	an	DT
cord-295559-yc8q62z8	112	13	important	important	JJ
cord-295559-yc8q62z8	112	14	research	research	NN
cord-295559-yc8q62z8	112	15	priority	priority	NN
cord-295559-yc8q62z8	112	16	to	to	TO
cord-295559-yc8q62z8	112	17	show	show	VB
cord-295559-yc8q62z8	112	18	whether	whether	IN
cord-295559-yc8q62z8	112	19	there	there	EX
cord-295559-yc8q62z8	112	20	is	be	VBZ
cord-295559-yc8q62z8	112	21	a	a	DT
cord-295559-yc8q62z8	112	22	common	common	JJ
cord-295559-yc8q62z8	112	23	epitope	epitope	NN
cord-295559-yc8q62z8	112	24	in	in	IN
cord-295559-yc8q62z8	112	25	S	s	NN
cord-295559-yc8q62z8	112	26	that	that	WDT
cord-295559-yc8q62z8	112	27	could	could	MD
cord-295559-yc8q62z8	112	28	be	be	VB
cord-295559-yc8q62z8	112	29	used	use	VBN
cord-295559-yc8q62z8	112	30	as	as	IN
cord-295559-yc8q62z8	112	31	an	an	DT
cord-295559-yc8q62z8	112	32	immunogen	immunogen	NN
cord-295559-yc8q62z8	112	33	to	to	TO
cord-295559-yc8q62z8	112	34	vaccinate	vaccinate	VB
cord-295559-yc8q62z8	112	35	against	against	IN
cord-295559-yc8q62z8	112	36	all	all	DT
cord-295559-yc8q62z8	112	37	betacoronaviruses	betacoronaviruse	NNS
cord-295559-yc8q62z8	112	38	.	.	.
cord-295559-yc8q62z8	113	1	Enveloped	envelop	VBN
cord-295559-yc8q62z8	113	2	viruses	virus	NNS
cord-295559-yc8q62z8	113	3	infect	infect	VBP
cord-295559-yc8q62z8	113	4	cells	cell	NNS
cord-295559-yc8q62z8	113	5	by	by	IN
cord-295559-yc8q62z8	113	6	fusion	fusion	NN
cord-295559-yc8q62z8	113	7	of	of	IN
cord-295559-yc8q62z8	113	8	the	the	DT
cord-295559-yc8q62z8	113	9	viral	viral	JJ
cord-295559-yc8q62z8	113	10	envelope	envelope	NN
cord-295559-yc8q62z8	113	11	with	with	IN
cord-295559-yc8q62z8	113	12	host	host	NN
cord-295559-yc8q62z8	113	13	cell	cell	NN
cord-295559-yc8q62z8	113	14	membranes	membrane	NNS
cord-295559-yc8q62z8	113	15	,	,	,
cord-295559-yc8q62z8	113	16	a	a	DT
cord-295559-yc8q62z8	113	17	process	process	NN
cord-295559-yc8q62z8	113	18	mediated	mediate	VBN
cord-295559-yc8q62z8	113	19	by	by	IN
cord-295559-yc8q62z8	113	20	a	a	DT
cord-295559-yc8q62z8	113	21	series	series	NN
cord-295559-yc8q62z8	113	22	of	of	IN
cord-295559-yc8q62z8	113	23	conformational	conformational	JJ
cord-295559-yc8q62z8	113	24	changes	change	NNS
cord-295559-yc8q62z8	113	25	in	in	IN
cord-295559-yc8q62z8	113	26	the	the	DT
cord-295559-yc8q62z8	113	27	viral	viral	JJ
cord-295559-yc8q62z8	113	28	fusion	fusion	NN
cord-295559-yc8q62z8	113	29	protein	protein	NN
cord-295559-yc8q62z8	113	30	that	that	WDT
cord-295559-yc8q62z8	113	31	are	be	VBP
cord-295559-yc8q62z8	113	32	regulated	regulate	VBN
cord-295559-yc8q62z8	113	33	by	by	IN
cord-295559-yc8q62z8	113	34	receptor	receptor	NN
cord-295559-yc8q62z8	113	35	binding	binding	NN
cord-295559-yc8q62z8	113	36	,	,	,
cord-295559-yc8q62z8	113	37	protease	protease	NN
cord-295559-yc8q62z8	113	38	activation	activation	NN
cord-295559-yc8q62z8	113	39	,	,	,
cord-295559-yc8q62z8	114	1	and/or	and/or	CC
cord-295559-yc8q62z8	114	2	pH	pH	NNP
cord-295559-yc8q62z8	114	3	[	[	-LRB-
cord-295559-yc8q62z8	114	4	17	17	CD
cord-295559-yc8q62z8	114	5	]	]	-RRB-
cord-295559-yc8q62z8	114	6	.	.	.
cord-295559-yc8q62z8	115	1	The	the	DT
cord-295559-yc8q62z8	115	2	classes	class	NNS
cord-295559-yc8q62z8	115	3	of	of	IN
cord-295559-yc8q62z8	115	4	viral	viral	JJ
cord-295559-yc8q62z8	115	5	fusion	fusion	NN
cord-295559-yc8q62z8	115	6	proteins	protein	NNS
cord-295559-yc8q62z8	115	7	are	be	VBP
cord-295559-yc8q62z8	115	8	determined	determine	VBN
cord-295559-yc8q62z8	115	9	based	base	VBN
cord-295559-yc8q62z8	115	10	on	on	IN
cord-295559-yc8q62z8	115	11	their	-PRON-	PRP$
cord-295559-yc8q62z8	115	12	structures	structure	NNS
cord-295559-yc8q62z8	115	13	and	and	CC
cord-295559-yc8q62z8	115	14	conformational	conformational	JJ
cord-295559-yc8q62z8	115	15	changes	change	NNS
cord-295559-yc8q62z8	115	16	during	during	IN
cord-295559-yc8q62z8	115	17	membrane	membrane	NN
cord-295559-yc8q62z8	115	18	fusion	fusion	NN
cord-295559-yc8q62z8	115	19	.	.	.
cord-295559-yc8q62z8	116	1	Most	Most	JJS
cord-295559-yc8q62z8	116	2	class	class	NN
cord-295559-yc8q62z8	117	1	I	-PRON-	PRP
cord-295559-yc8q62z8	117	2	viral	viral	JJ
cord-295559-yc8q62z8	117	3	fusion	fusion	NN
cord-295559-yc8q62z8	117	4	proteins	protein	NNS
cord-295559-yc8q62z8	117	5	require	require	VBP
cord-295559-yc8q62z8	117	6	proteolytic	proteolytic	JJ
cord-295559-yc8q62z8	117	7	cleavage	cleavage	NN
cord-295559-yc8q62z8	117	8	upstream	upstream	RB
cord-295559-yc8q62z8	117	9	of	of	IN
cord-295559-yc8q62z8	117	10	the	the	DT
cord-295559-yc8q62z8	117	11	hydrophobic	hydrophobic	JJ
cord-295559-yc8q62z8	117	12	fusion	fusion	NN
cord-295559-yc8q62z8	117	13	peptide	peptide	NN
cord-295559-yc8q62z8	117	14	in	in	IN
cord-295559-yc8q62z8	117	15	the	the	DT
cord-295559-yc8q62z8	117	16	viral	viral	JJ
cord-295559-yc8q62z8	117	17	spike	spike	NN
cord-295559-yc8q62z8	117	18	protein	protein	NN
cord-295559-yc8q62z8	117	19	to	to	TO
cord-295559-yc8q62z8	117	20	enable	enable	VB
cord-295559-yc8q62z8	117	21	these	these	DT
cord-295559-yc8q62z8	117	22	conformational	conformational	JJ
cord-295559-yc8q62z8	117	23	changes	change	NNS
cord-295559-yc8q62z8	117	24	to	to	TO
cord-295559-yc8q62z8	117	25	occur	occur	VB
cord-295559-yc8q62z8	117	26	,	,	,
cord-295559-yc8q62z8	117	27	as	as	RB
cord-295559-yc8q62z8	117	28	well	well	RB
cord-295559-yc8q62z8	117	29	as	as	IN
cord-295559-yc8q62z8	117	30	subsequent	subsequent	JJ
cord-295559-yc8q62z8	117	31	steps	step	NNS
cord-295559-yc8q62z8	117	32	that	that	WDT
cord-295559-yc8q62z8	117	33	trigger	trigger	VBP
cord-295559-yc8q62z8	117	34	membrane	membrane	NN
cord-295559-yc8q62z8	117	35	fusion	fusion	NN
cord-295559-yc8q62z8	117	36	including	include	VBG
cord-295559-yc8q62z8	117	37	either	either	CC
cord-295559-yc8q62z8	117	38	binding	bind	VBG
cord-295559-yc8q62z8	117	39	to	to	IN
cord-295559-yc8q62z8	117	40	receptor	receptor	NN
cord-295559-yc8q62z8	117	41	like	like	IN
cord-295559-yc8q62z8	117	42	HIV	HIV	NNP
cord-295559-yc8q62z8	117	43	gp120	gp120	NNP
cord-295559-yc8q62z8	117	44	,	,	,
cord-295559-yc8q62z8	117	45	low	low	JJ
cord-295559-yc8q62z8	117	46	pH	ph	NN
cord-295559-yc8q62z8	117	47	in	in	IN
cord-295559-yc8q62z8	117	48	endosomes	endosome	NNS
cord-295559-yc8q62z8	117	49	like	like	IN
cord-295559-yc8q62z8	117	50	influenza	influenza	NN
cord-295559-yc8q62z8	117	51	HA	HA	NNP
cord-295559-yc8q62z8	117	52	,	,	,
cord-295559-yc8q62z8	117	53	or	or	CC
cord-295559-yc8q62z8	117	54	both	both	DT
cord-295559-yc8q62z8	117	55	like	like	IN
cord-295559-yc8q62z8	117	56	avian	avian	JJ
cord-295559-yc8q62z8	117	57	sarcoma	sarcoma	NN
cord-295559-yc8q62z8	117	58	leukosis	leukosis	NN
cord-295559-yc8q62z8	117	59	virus	virus	NN
cord-295559-yc8q62z8	117	60	(	(	-LRB-
cord-295559-yc8q62z8	117	61	ASLV	ASLV	NNP
cord-295559-yc8q62z8	117	62	)	)	-RRB-
cord-295559-yc8q62z8	118	1	[	[	-LRB-
cord-295559-yc8q62z8	118	2	9	9	CD
cord-295559-yc8q62z8	118	3	,	,	,
cord-295559-yc8q62z8	118	4	17	17	CD
cord-295559-yc8q62z8	118	5	,	,	,
cord-295559-yc8q62z8	118	6	[	[	-LRB-
cord-295559-yc8q62z8	118	7	54	54	CD
cord-295559-yc8q62z8	118	8	]	]	-RRB-
cord-295559-yc8q62z8	119	1	[	[	-LRB-
cord-295559-yc8q62z8	119	2	55	55	CD
cord-295559-yc8q62z8	119	3	]	]	-RRB-
cord-295559-yc8q62z8	119	4	[	[	-LRB-
cord-295559-yc8q62z8	119	5	56	56	CD
cord-295559-yc8q62z8	119	6	]	]	-RRB-
cord-295559-yc8q62z8	119	7	.	.	.
cord-295559-yc8q62z8	120	1	Coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	120	2	in	in	IN
cord-295559-yc8q62z8	120	3	different	different	JJ
cord-295559-yc8q62z8	120	4	phylogenetic	phylogenetic	JJ
cord-295559-yc8q62z8	120	5	groups	group	NNS
cord-295559-yc8q62z8	120	6	differ	differ	VBP
cord-295559-yc8q62z8	120	7	in	in	IN
cord-295559-yc8q62z8	120	8	the	the	DT
cord-295559-yc8q62z8	120	9	sequence	sequence	NN
cord-295559-yc8q62z8	120	10	of	of	IN
cord-295559-yc8q62z8	120	11	steps	step	NNS
cord-295559-yc8q62z8	120	12	leading	lead	VBG
cord-295559-yc8q62z8	120	13	to	to	IN
cord-295559-yc8q62z8	120	14	virus	virus	NN
cord-295559-yc8q62z8	120	15	entry	entry	NN
cord-295559-yc8q62z8	120	16	[	[	-LRB-
cord-295559-yc8q62z8	120	17	57	57	CD
cord-295559-yc8q62z8	120	18	,	,	,
cord-295559-yc8q62z8	120	19	58	58	CD
cord-295559-yc8q62z8	120	20	]	]	-RRB-
cord-295559-yc8q62z8	120	21	.	.	.
cord-295559-yc8q62z8	121	1	The	the	DT
cord-295559-yc8q62z8	121	2	S	S	NNP
cord-295559-yc8q62z8	121	3	protein	protein	NN
cord-295559-yc8q62z8	121	4	on	on	IN
cord-295559-yc8q62z8	121	5	virions	virion	NNS
cord-295559-yc8q62z8	121	6	of	of	IN
cord-295559-yc8q62z8	121	7	group	group	NN
cord-295559-yc8q62z8	122	1	a	a	DT
cord-295559-yc8q62z8	122	2	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	122	3	MHV	MHV	NNP
cord-295559-yc8q62z8	122	4	-	-	HYPH
cord-295559-yc8q62z8	122	5	A59	A59	NNP
cord-295559-yc8q62z8	122	6	requires	require	VBZ
cord-295559-yc8q62z8	122	7	protease	protease	NN
cord-295559-yc8q62z8	122	8	activation	activation	NN
cord-295559-yc8q62z8	122	9	--	--	:
cord-295559-yc8q62z8	122	10	either	either	CC
cord-295559-yc8q62z8	122	11	by	by	IN
cord-295559-yc8q62z8	122	12	furin	furin	NN
cord-295559-yc8q62z8	122	13	during	during	IN
cord-295559-yc8q62z8	122	14	virus	virus	NN
cord-295559-yc8q62z8	122	15	maturation	maturation	NN
cord-295559-yc8q62z8	122	16	[	[	-LRB-
cord-295559-yc8q62z8	122	17	18	18	CD
cord-295559-yc8q62z8	122	18	]	]	-RRB-
cord-295559-yc8q62z8	122	19	,	,	,
cord-295559-yc8q62z8	122	20	by	by	IN
cord-295559-yc8q62z8	122	21	trypsin	trypsin	NN
cord-295559-yc8q62z8	122	22	or	or	CC
cord-295559-yc8q62z8	122	23	other	other	JJ
cord-295559-yc8q62z8	122	24	serine	serine	NN
cord-295559-yc8q62z8	122	25	proteases	protease	NNS
cord-295559-yc8q62z8	122	26	in	in	IN
cord-295559-yc8q62z8	122	27	extracellular	extracellular	JJ
cord-295559-yc8q62z8	122	28	fluids	fluid	NNS
cord-295559-yc8q62z8	122	29	before	before	IN
cord-295559-yc8q62z8	122	30	either	either	DT
cord-295559-yc8q62z8	122	31	receptor	receptor	NN
cord-295559-yc8q62z8	122	32	binding	binding	NN
cord-295559-yc8q62z8	122	33	,	,	,
cord-295559-yc8q62z8	122	34	or	or	CC
cord-295559-yc8q62z8	122	35	by	by	IN
cord-295559-yc8q62z8	122	36	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	122	37	in	in	IN
cord-295559-yc8q62z8	122	38	endosomes	endosome	NNS
cord-295559-yc8q62z8	122	39	at	at	IN
cord-295559-yc8q62z8	122	40	acidic	acidic	JJ
cord-295559-yc8q62z8	122	41	pH	ph	NN
cord-295559-yc8q62z8	122	42	-	-	:
cord-295559-yc8q62z8	122	43	to	to	TO
cord-295559-yc8q62z8	122	44	trigger	trigger	VB
cord-295559-yc8q62z8	122	45	the	the	DT
cord-295559-yc8q62z8	122	46	conformational	conformational	JJ
cord-295559-yc8q62z8	122	47	changes	change	NNS
cord-295559-yc8q62z8	122	48	that	that	WDT
cord-295559-yc8q62z8	122	49	lead	lead	VBP
cord-295559-yc8q62z8	122	50	to	to	IN
cord-295559-yc8q62z8	122	51	membrane	membrane	NN
cord-295559-yc8q62z8	122	52	fusion	fusion	NN
cord-295559-yc8q62z8	122	53	and	and	CC
cord-295559-yc8q62z8	122	54	virus	virus	NN
cord-295559-yc8q62z8	122	55	entry	entry	NN
cord-295559-yc8q62z8	122	56	[	[	-LRB-
cord-295559-yc8q62z8	122	57	59	59	CD
cord-295559-yc8q62z8	122	58	]	]	-RRB-
cord-295559-yc8q62z8	122	59	.	.	.
cord-295559-yc8q62z8	123	1	In	in	IN
cord-295559-yc8q62z8	123	2	contrast	contrast	NN
cord-295559-yc8q62z8	123	3	,	,	,
cord-295559-yc8q62z8	123	4	virions	virion	NNS
cord-295559-yc8q62z8	123	5	of	of	IN
cord-295559-yc8q62z8	123	6	group	group	NN
cord-295559-yc8q62z8	123	7	b	b	NNP
cord-295559-yc8q62z8	123	8	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	123	9	SARS	SARS	NNP
cord-295559-yc8q62z8	123	10	-	-	HYPH
cord-295559-yc8q62z8	123	11	CoV	CoV	NNP
cord-295559-yc8q62z8	123	12	that	that	WDT
cord-295559-yc8q62z8	123	13	contain	contain	VBP
cord-295559-yc8q62z8	123	14	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	123	15	S	S	NNP
cord-295559-yc8q62z8	123	16	[	[	-LRB-
cord-295559-yc8q62z8	123	17	22	22	CD
cord-295559-yc8q62z8	123	18	]	]	-RRB-
cord-295559-yc8q62z8	123	19	,	,	,
cord-295559-yc8q62z8	123	20	first	first	JJ
cord-295559-yc8q62z8	123	21	bind	bind	NN
cord-295559-yc8q62z8	123	22	to	to	IN
cord-295559-yc8q62z8	123	23	the	the	DT
cord-295559-yc8q62z8	123	24	viral	viral	JJ
cord-295559-yc8q62z8	123	25	receptor	receptor	NN
cord-295559-yc8q62z8	123	26	protein	protein	NN
cord-295559-yc8q62z8	123	27	,	,	,
cord-295559-yc8q62z8	123	28	ACE2	ACE2	NNP
cord-295559-yc8q62z8	123	29	,	,	,
cord-295559-yc8q62z8	123	30	and	and	CC
cord-295559-yc8q62z8	123	31	are	be	VBP
cord-295559-yc8q62z8	123	32	endocytosed	endocytose	VBN
cord-295559-yc8q62z8	123	33	,	,	,
cord-295559-yc8q62z8	123	34	and	and	CC
cord-295559-yc8q62z8	123	35	then	then	RB
cord-295559-yc8q62z8	123	36	S	S	NNP
cord-295559-yc8q62z8	123	37	is	be	VBZ
cord-295559-yc8q62z8	123	38	cleaved	cleave	VBN
cord-295559-yc8q62z8	123	39	within	within	IN
cord-295559-yc8q62z8	123	40	endosomal	endosomal	JJ
cord-295559-yc8q62z8	123	41	vesicles	vesicle	NNS
cord-295559-yc8q62z8	123	42	by	by	IN
cord-295559-yc8q62z8	123	43	acid	acid	NN
cord-295559-yc8q62z8	123	44	-	-	HYPH
cord-295559-yc8q62z8	123	45	dependent	dependent	JJ
cord-295559-yc8q62z8	123	46	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	123	47	L	l	NN
cord-295559-yc8q62z8	123	48	enabling	enable	VBG
cord-295559-yc8q62z8	123	49	the	the	DT
cord-295559-yc8q62z8	123	50	conformational	conformational	JJ
cord-295559-yc8q62z8	123	51	changes	change	NNS
cord-295559-yc8q62z8	123	52	in	in	IN
cord-295559-yc8q62z8	123	53	S	S	NNP
cord-295559-yc8q62z8	123	54	that	that	WDT
cord-295559-yc8q62z8	123	55	lead	lead	VBP
cord-295559-yc8q62z8	123	56	to	to	IN
cord-295559-yc8q62z8	123	57	virus	virus	NN
cord-295559-yc8q62z8	123	58	entry	entry	NN
cord-295559-yc8q62z8	123	59	[	[	-LRB-
cord-295559-yc8q62z8	123	60	21	21	CD
cord-295559-yc8q62z8	123	61	,	,	,
cord-295559-yc8q62z8	123	62	22	22	CD
cord-295559-yc8q62z8	123	63	,	,	,
cord-295559-yc8q62z8	123	64	60	60	CD
cord-295559-yc8q62z8	123	65	]	]	-RRB-
cord-295559-yc8q62z8	123	66	.	.	.
cord-295559-yc8q62z8	124	1	Here	here	RB
cord-295559-yc8q62z8	124	2	we	-PRON-	PRP
cord-295559-yc8q62z8	124	3	analyzed	analyze	VBD
cord-295559-yc8q62z8	124	4	the	the	DT
cord-295559-yc8q62z8	124	5	steps	step	NNS
cord-295559-yc8q62z8	124	6	needed	need	VBN
cord-295559-yc8q62z8	124	7	to	to	TO
cord-295559-yc8q62z8	124	8	trigger	trigger	VB
cord-295559-yc8q62z8	124	9	conformational	conformational	JJ
cord-295559-yc8q62z8	124	10	changes	change	NNS
cord-295559-yc8q62z8	124	11	in	in	IN
cord-295559-yc8q62z8	124	12	MERS	MERS	NNP
cord-295559-yc8q62z8	124	13	-	-	HYPH
cord-295559-yc8q62z8	124	14	CoV	CoV	NNP
cord-295559-yc8q62z8	124	15	S	S	NNP
cord-295559-yc8q62z8	124	16	and	and	CC
cord-295559-yc8q62z8	124	17	their	-PRON-	PRP$
cord-295559-yc8q62z8	124	18	roles	role	NNS
cord-295559-yc8q62z8	124	19	in	in	IN
cord-295559-yc8q62z8	124	20	virus	virus	NN
cord-295559-yc8q62z8	124	21	entry	entry	NN
cord-295559-yc8q62z8	124	22	and	and	CC
cord-295559-yc8q62z8	124	23	syncytia	syncytia	NN
cord-295559-yc8q62z8	124	24	formation	formation	NN
cord-295559-yc8q62z8	124	25	.	.	.
cord-295559-yc8q62z8	125	1	In	in	IN
cord-295559-yc8q62z8	125	2	our	-PRON-	PRP$
cord-295559-yc8q62z8	125	3	laboratory	laboratory	NN
cord-295559-yc8q62z8	125	4	,	,	,
cord-295559-yc8q62z8	125	5	MERS	MERS	NNP
cord-295559-yc8q62z8	125	6	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	125	7	released	release	VBN
cord-295559-yc8q62z8	125	8	by	by	IN
cord-295559-yc8q62z8	125	9	293	293	CD
cord-295559-yc8q62z8	125	10	T	t	NN
cord-295559-yc8q62z8	125	11	cells	cell	NNS
cord-295559-yc8q62z8	125	12	contained	contain	VBD
cord-295559-yc8q62z8	125	13	only	only	RB
cord-295559-yc8q62z8	125	14	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	125	15	S	S	NNP
cord-295559-yc8q62z8	125	16	protein	protein	NN
cord-295559-yc8q62z8	125	17	,	,	,
cord-295559-yc8q62z8	125	18	and	and	CC
cord-295559-yc8q62z8	125	19	,	,	,
cord-295559-yc8q62z8	125	20	as	as	IN
cord-295559-yc8q62z8	125	21	for	for	IN
cord-295559-yc8q62z8	125	22	most	most	JJS
cord-295559-yc8q62z8	125	23	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	125	24	,	,	,
cord-295559-yc8q62z8	125	25	cleavage	cleavage	NN
cord-295559-yc8q62z8	125	26	between	between	IN
cord-295559-yc8q62z8	125	27	S1	S1	NNP
cord-295559-yc8q62z8	125	28	and	and	CC
cord-295559-yc8q62z8	125	29	S2	S2	NNP
cord-295559-yc8q62z8	125	30	was	be	VBD
cord-295559-yc8q62z8	125	31	necessary	necessary	JJ
cord-295559-yc8q62z8	125	32	to	to	TO
cord-295559-yc8q62z8	125	33	enable	enable	VB
cord-295559-yc8q62z8	125	34	its	-PRON-	PRP$
cord-295559-yc8q62z8	125	35	membrane	membrane	NN
cord-295559-yc8q62z8	125	36	fusing	fuse	VBG
cord-295559-yc8q62z8	125	37	activity	activity	NN
cord-295559-yc8q62z8	125	38	.	.	.
cord-295559-yc8q62z8	126	1	The	the	DT
cord-295559-yc8q62z8	126	2	MERS	MERS	NNP
cord-295559-yc8q62z8	126	3	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	126	4	bound	bind	VBN
cord-295559-yc8q62z8	126	5	to	to	IN
cord-295559-yc8q62z8	126	6	receptors	receptor	NNS
cord-295559-yc8q62z8	126	7	on	on	IN
cord-295559-yc8q62z8	126	8	susceptible	susceptible	JJ
cord-295559-yc8q62z8	126	9	cells	cell	NNS
cord-295559-yc8q62z8	126	10	and	and	CC
cord-295559-yc8q62z8	126	11	were	be	VBD
cord-295559-yc8q62z8	126	12	endocytized	endocytize	VBN
cord-295559-yc8q62z8	126	13	,	,	,
cord-295559-yc8q62z8	126	14	and	and	CC
cord-295559-yc8q62z8	126	15	within	within	IN
cord-295559-yc8q62z8	126	16	the	the	DT
cord-295559-yc8q62z8	126	17	endosomes	endosome	NNS
cord-295559-yc8q62z8	126	18	cleavage	cleavage	NN
cord-295559-yc8q62z8	126	19	of	of	IN
cord-295559-yc8q62z8	126	20	S	S	NNP
cord-295559-yc8q62z8	126	21	by	by	IN
cord-295559-yc8q62z8	126	22	the	the	DT
cord-295559-yc8q62z8	126	23	acid	acid	NN
cord-295559-yc8q62z8	126	24	-	-	HYPH
cord-295559-yc8q62z8	126	25	dependent	dependent	JJ
cord-295559-yc8q62z8	126	26	cysteine	cysteine	NN
cord-295559-yc8q62z8	126	27	protease	protease	NN
cord-295559-yc8q62z8	126	28	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	126	29	L	l	NN
cord-295559-yc8q62z8	126	30	mediated	mediate	VBD
cord-295559-yc8q62z8	126	31	virus	virus	NN
cord-295559-yc8q62z8	126	32	entry	entry	NN
cord-295559-yc8q62z8	126	33	.	.	.
cord-295559-yc8q62z8	127	1	Gierer	Gierer	NNP
cord-295559-yc8q62z8	127	2	et	et	FW
cord-295559-yc8q62z8	127	3	al	al	NNP
cord-295559-yc8q62z8	127	4	[	[	-LRB-
cord-295559-yc8q62z8	127	5	33	33	CD
cord-295559-yc8q62z8	127	6	]	]	-RRB-
cord-295559-yc8q62z8	127	7	reached	reach	VBN
cord-295559-yc8q62z8	127	8	similar	similar	JJ
cord-295559-yc8q62z8	127	9	conclusions	conclusion	NNS
cord-295559-yc8q62z8	127	10	using	use	VBG
cord-295559-yc8q62z8	127	11	MERS	MERS	NNP
cord-295559-yc8q62z8	127	12	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	127	13	that	that	IN
cord-295559-yc8q62z8	127	14	,	,	,
cord-295559-yc8q62z8	127	15	unlike	unlike	IN
cord-295559-yc8q62z8	127	16	ours	our	NNS
cord-295559-yc8q62z8	127	17	,	,	,
cord-295559-yc8q62z8	127	18	contained	contain	VBD
cord-295559-yc8q62z8	127	19	more	more	RBR
cord-295559-yc8q62z8	127	20	cleaved	cleave	VBN
cord-295559-yc8q62z8	127	21	than	than	IN
cord-295559-yc8q62z8	127	22	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	127	23	S	S	NNP
cord-295559-yc8q62z8	127	24	protein	protein	NN
cord-295559-yc8q62z8	127	25	,	,	,
cord-295559-yc8q62z8	127	26	although	although	IN
cord-295559-yc8q62z8	127	27	both	both	DT
cord-295559-yc8q62z8	127	28	labs	lab	NNS
cord-295559-yc8q62z8	127	29	had	have	VBD
cord-295559-yc8q62z8	127	30	made	make	VBN
cord-295559-yc8q62z8	127	31	the	the	DT
cord-295559-yc8q62z8	127	32	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	127	33	in	in	IN
cord-295559-yc8q62z8	127	34	293	293	CD
cord-295559-yc8q62z8	127	35	T	T	NNP
cord-295559-yc8q62z8	127	36	cells	cell	NNS
cord-295559-yc8q62z8	127	37	.	.	.
cord-295559-yc8q62z8	128	1	Gierer	Gierer	NNP
cord-295559-yc8q62z8	128	2	et	et	FW
cord-295559-yc8q62z8	128	3	al	al	NNP
cord-295559-yc8q62z8	128	4	.	.	.
cord-295559-yc8q62z8	129	1	[	[	-LRB-
cord-295559-yc8q62z8	129	2	33	33	CD
cord-295559-yc8q62z8	129	3	]	]	-RRB-
cord-295559-yc8q62z8	129	4	showed	show	VBD
cord-295559-yc8q62z8	129	5	that	that	IN
cord-295559-yc8q62z8	129	6	batches	batch	NNS
cord-295559-yc8q62z8	129	7	of	of	IN
cord-295559-yc8q62z8	129	8	293	293	CD
cord-295559-yc8q62z8	129	9	T	t	NN
cord-295559-yc8q62z8	129	10	cells	cell	NNS
cord-295559-yc8q62z8	129	11	differ	differ	VBP
cord-295559-yc8q62z8	129	12	markedly	markedly	RB
cord-295559-yc8q62z8	129	13	in	in	IN
cord-295559-yc8q62z8	129	14	expression	expression	NN
cord-295559-yc8q62z8	129	15	of	of	IN
cord-295559-yc8q62z8	129	16	the	the	DT
cord-295559-yc8q62z8	129	17	MERS	MERS	NNP
cord-295559-yc8q62z8	129	18	-	-	HYPH
cord-295559-yc8q62z8	129	19	CoV	cov	NN
cord-295559-yc8q62z8	129	20	receptor	receptor	NN
cord-295559-yc8q62z8	129	21	and	and	CC
cord-295559-yc8q62z8	129	22	susceptibility	susceptibility	NN
cord-295559-yc8q62z8	129	23	to	to	IN
cord-295559-yc8q62z8	129	24	transduction	transduction	NN
cord-295559-yc8q62z8	129	25	by	by	IN
cord-295559-yc8q62z8	129	26	MERS	MERS	NNP
cord-295559-yc8q62z8	129	27	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	129	28	.	.	.
cord-295559-yc8q62z8	130	1	In	in	IN
cord-295559-yc8q62z8	130	2	our	-PRON-	PRP$
cord-295559-yc8q62z8	130	3	laboratory	laboratory	NN
cord-295559-yc8q62z8	130	4	,	,	,
cord-295559-yc8q62z8	130	5	the	the	DT
cord-295559-yc8q62z8	130	6	293	293	CD
cord-295559-yc8q62z8	130	7	T	T	NNP
cord-295559-yc8q62z8	130	8	cells	cell	NNS
cord-295559-yc8q62z8	130	9	showed	show	VBD
cord-295559-yc8q62z8	130	10	minimal	minimal	JJ
cord-295559-yc8q62z8	130	11	susceptibility	susceptibility	NN
cord-295559-yc8q62z8	130	12	to	to	IN
cord-295559-yc8q62z8	130	13	transduction	transduction	NN
cord-295559-yc8q62z8	130	14	with	with	IN
cord-295559-yc8q62z8	130	15	MERS	MERS	NNP
cord-295559-yc8q62z8	130	16	-	-	HYPH
cord-295559-yc8q62z8	130	17	CoV	CoV	NNP
cord-295559-yc8q62z8	130	18	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	130	19	with	with	IN
cord-295559-yc8q62z8	130	20	uncleaved	uncleaved	NNP
cord-295559-yc8q62z8	130	21	S	S	NNP
cord-295559-yc8q62z8	130	22	protein	protein	NN
cord-295559-yc8q62z8	130	23	.	.	.
cord-295559-yc8q62z8	131	1	In	in	IN
cord-295559-yc8q62z8	131	2	addition	addition	NN
cord-295559-yc8q62z8	131	3	to	to	IN
cord-295559-yc8q62z8	131	4	entry	entry	NN
cord-295559-yc8q62z8	131	5	by	by	IN
cord-295559-yc8q62z8	131	6	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	131	7	,	,	,
cord-295559-yc8q62z8	131	8	we	-PRON-	PRP
cord-295559-yc8q62z8	131	9	showed	show	VBD
cord-295559-yc8q62z8	131	10	that	that	IN
cord-295559-yc8q62z8	131	11	,	,	,
cord-295559-yc8q62z8	131	12	like	like	IN
cord-295559-yc8q62z8	131	13	SARS	SARS	NNP
cord-295559-yc8q62z8	131	14	-	-	HYPH
cord-295559-yc8q62z8	131	15	CoV	CoV	NNP
cord-295559-yc8q62z8	131	16	[	[	-LRB-
cord-295559-yc8q62z8	131	17	21	21	CD
cord-295559-yc8q62z8	131	18	,	,	,
cord-295559-yc8q62z8	131	19	22	22	CD
cord-295559-yc8q62z8	131	20	]	]	-RRB-
cord-295559-yc8q62z8	131	21	,	,	,
cord-295559-yc8q62z8	131	22	MERS	MERS	NNP
cord-295559-yc8q62z8	131	23	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	131	24	could	could	MD
cord-295559-yc8q62z8	131	25	enter	enter	VB
cord-295559-yc8q62z8	131	26	susceptible	susceptible	JJ
cord-295559-yc8q62z8	131	27	Vero	Vero	NNP
cord-295559-yc8q62z8	131	28	E6	E6	NNP
cord-295559-yc8q62z8	131	29	cells	cell	NNS
cord-295559-yc8q62z8	131	30	at	at	IN
cord-295559-yc8q62z8	131	31	the	the	DT
cord-295559-yc8q62z8	131	32	plasma	plasma	NN
cord-295559-yc8q62z8	131	33	membrane	membrane	NN
cord-295559-yc8q62z8	131	34	if	if	IN
cord-295559-yc8q62z8	131	35	virions	virion	NNS
cord-295559-yc8q62z8	131	36	were	be	VBD
cord-295559-yc8q62z8	131	37	first	first	RB
cord-295559-yc8q62z8	131	38	bound	bind	VBN
cord-295559-yc8q62z8	131	39	to	to	IN
cord-295559-yc8q62z8	131	40	cell	cell	NN
cord-295559-yc8q62z8	131	41	surface	surface	NN
cord-295559-yc8q62z8	131	42	receptors	receptor	NNS
cord-295559-yc8q62z8	131	43	at	at	IN
cord-295559-yc8q62z8	131	44	4	4	CD
cord-295559-yc8q62z8	131	45	°	°	NN
cord-295559-yc8q62z8	131	46	C	c	NN
cord-295559-yc8q62z8	131	47	at	at	IN
cord-295559-yc8q62z8	131	48	neutral	neutral	JJ
cord-295559-yc8q62z8	131	49	pH	ph	NN
cord-295559-yc8q62z8	131	50	in	in	IN
cord-295559-yc8q62z8	131	51	the	the	DT
cord-295559-yc8q62z8	131	52	presence	presence	NN
cord-295559-yc8q62z8	131	53	of	of	IN
cord-295559-yc8q62z8	131	54	NH	NH	NNP
cord-295559-yc8q62z8	131	55	4	4	CD
cord-295559-yc8q62z8	131	56	Cl	Cl	NNP
cord-295559-yc8q62z8	131	57	to	to	TO
cord-295559-yc8q62z8	131	58	inhibit	inhibit	VB
cord-295559-yc8q62z8	131	59	acidification	acidification	NN
cord-295559-yc8q62z8	131	60	of	of	IN
cord-295559-yc8q62z8	131	61	endosomes	endosome	NNS
cord-295559-yc8q62z8	131	62	,	,	,
cord-295559-yc8q62z8	131	63	and	and	CC
cord-295559-yc8q62z8	131	64	also	also	RB
cord-295559-yc8q62z8	131	65	treated	treat	VBN
cord-295559-yc8q62z8	131	66	briefly	briefly	RB
cord-295559-yc8q62z8	131	67	at	at	IN
cord-295559-yc8q62z8	131	68	room	room	NN
cord-295559-yc8q62z8	131	69	temperature	temperature	NN
cord-295559-yc8q62z8	131	70	with	with	IN
cord-295559-yc8q62z8	131	71	trypsin	trypsin	NN
cord-295559-yc8q62z8	131	72	to	to	TO
cord-295559-yc8q62z8	131	73	cleave	cleave	VB
cord-295559-yc8q62z8	131	74	the	the	DT
cord-295559-yc8q62z8	131	75	viral	viral	JJ
cord-295559-yc8q62z8	131	76	S	S	NNP
cord-295559-yc8q62z8	131	77	protein	protein	NN
cord-295559-yc8q62z8	131	78	.	.	.
cord-295559-yc8q62z8	132	1	Upon	upon	IN
cord-295559-yc8q62z8	132	2	warming	warm	VBG
cord-295559-yc8q62z8	132	3	to	to	IN
cord-295559-yc8q62z8	132	4	37	37	CD
cord-295559-yc8q62z8	132	5	°	°	NN
cord-295559-yc8q62z8	132	6	C	c	NN
cord-295559-yc8q62z8	132	7	at	at	IN
cord-295559-yc8q62z8	132	8	neutral	neutral	JJ
cord-295559-yc8q62z8	132	9	pH	pH	NNP
cord-295559-yc8q62z8	132	10	,	,	,
cord-295559-yc8q62z8	132	11	the	the	DT
cord-295559-yc8q62z8	132	12	MERS	MERS	NNP
cord-295559-yc8q62z8	132	13	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	132	14	fused	fuse	VBN
cord-295559-yc8q62z8	132	15	with	with	IN
cord-295559-yc8q62z8	132	16	the	the	DT
cord-295559-yc8q62z8	132	17	plasma	plasma	NN
cord-295559-yc8q62z8	132	18	membrane	membrane	NN
cord-295559-yc8q62z8	132	19	and	and	CC
cord-295559-yc8q62z8	132	20	transduced	transduce	VBD
cord-295559-yc8q62z8	132	21	the	the	DT
cord-295559-yc8q62z8	132	22	cells	cell	NNS
cord-295559-yc8q62z8	132	23	.	.	.
cord-295559-yc8q62z8	133	1	Thus	thus	RB
cord-295559-yc8q62z8	133	2	,	,	,
cord-295559-yc8q62z8	133	3	MERS	MERS	NNP
cord-295559-yc8q62z8	133	4	S	S	NNP
cord-295559-yc8q62z8	133	5	protein	protein	NN
cord-295559-yc8q62z8	133	6	does	do	VBZ
cord-295559-yc8q62z8	133	7	not	not	RB
cord-295559-yc8q62z8	133	8	require	require	VB
cord-295559-yc8q62z8	133	9	acidification	acidification	NN
cord-295559-yc8q62z8	133	10	to	to	TO
cord-295559-yc8q62z8	133	11	mediate	mediate	VB
cord-295559-yc8q62z8	133	12	virus	virus	NN
cord-295559-yc8q62z8	133	13	entry	entry	NN
cord-295559-yc8q62z8	133	14	,	,	,
cord-295559-yc8q62z8	133	15	and	and	CC
cord-295559-yc8q62z8	133	16	the	the	DT
cord-295559-yc8q62z8	133	17	acidification	acidification	NN
cord-295559-yc8q62z8	133	18	required	require	VBN
cord-295559-yc8q62z8	133	19	for	for	IN
cord-295559-yc8q62z8	133	20	endosomal	endosomal	NNP
cord-295559-yc8q62z8	133	21	entry	entry	NN
cord-295559-yc8q62z8	133	22	[	[	-LRB-
cord-295559-yc8q62z8	133	23	33	33	CD
cord-295559-yc8q62z8	133	24	]	]	-RRB-
cord-295559-yc8q62z8	133	25	was	be	VBD
cord-295559-yc8q62z8	133	26	required	require	VBN
cord-295559-yc8q62z8	133	27	to	to	TO
cord-295559-yc8q62z8	133	28	activate	activate	VB
cord-295559-yc8q62z8	133	29	the	the	DT
cord-295559-yc8q62z8	133	30	protease	protease	NN
cord-295559-yc8q62z8	133	31	activity	activity	NN
cord-295559-yc8q62z8	133	32	of	of	IN
cord-295559-yc8q62z8	133	33	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	133	34	.	.	.
cord-295559-yc8q62z8	134	1	Although	although	IN
cord-295559-yc8q62z8	134	2	treatment	treatment	NN
cord-295559-yc8q62z8	134	3	of	of	IN
cord-295559-yc8q62z8	134	4	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	134	5	virions	virion	NNS
cord-295559-yc8q62z8	134	6	or	or	CC
cord-295559-yc8q62z8	134	7	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	134	8	with	with	IN
cord-295559-yc8q62z8	134	9	proteases	protease	NNS
cord-295559-yc8q62z8	134	10	can	can	MD
cord-295559-yc8q62z8	134	11	activate	activate	VB
cord-295559-yc8q62z8	134	12	virus	virus	NN
cord-295559-yc8q62z8	134	13	entry	entry	NN
cord-295559-yc8q62z8	134	14	,	,	,
cord-295559-yc8q62z8	134	15	it	-PRON-	PRP
cord-295559-yc8q62z8	134	16	may	may	MD
cord-295559-yc8q62z8	134	17	also	also	RB
cord-295559-yc8q62z8	134	18	make	make	VB
cord-295559-yc8q62z8	134	19	them	-PRON-	PRP
cord-295559-yc8q62z8	134	20	lose	lose	VB
cord-295559-yc8q62z8	134	21	infectivity	infectivity	NN
cord-295559-yc8q62z8	134	22	if	if	IN
cord-295559-yc8q62z8	134	23	the	the	DT
cord-295559-yc8q62z8	134	24	cleaved	cleaved	JJ
cord-295559-yc8q62z8	134	25	S1	S1	NNP
cord-295559-yc8q62z8	134	26	/	/	SYM
cord-295559-yc8q62z8	134	27	S2	S2	NNP
cord-295559-yc8q62z8	134	28	heterodimer	heterodimer	NN
cord-295559-yc8q62z8	134	29	dissociates	dissociate	VBZ
cord-295559-yc8q62z8	134	30	before	before	IN
cord-295559-yc8q62z8	134	31	receptor	receptor	NN
cord-295559-yc8q62z8	134	32	binding	binding	NN
cord-295559-yc8q62z8	134	33	.	.	.
cord-295559-yc8q62z8	135	1	We	-PRON-	PRP
cord-295559-yc8q62z8	135	2	found	find	VBD
cord-295559-yc8q62z8	135	3	that	that	IN
cord-295559-yc8q62z8	135	4	MERS	MERS	NNP
cord-295559-yc8q62z8	135	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	135	6	released	release	VBN
cord-295559-yc8q62z8	135	7	from	from	IN
cord-295559-yc8q62z8	135	8	cells	cell	NNS
cord-295559-yc8q62z8	135	9	expressing	express	VBG
cord-295559-yc8q62z8	135	10	TMPRSS-2	TMPRSS-2	NNP
cord-295559-yc8q62z8	135	11	contained	contain	VBD
cord-295559-yc8q62z8	135	12	reduced	reduced	JJ
cord-295559-yc8q62z8	135	13	amounts	amount	NNS
cord-295559-yc8q62z8	135	14	of	of	IN
cord-295559-yc8q62z8	135	15	S	s	NN
cord-295559-yc8q62z8	135	16	protein	protein	NN
cord-295559-yc8q62z8	135	17	and	and	CC
cord-295559-yc8q62z8	135	18	had	have	VBD
cord-295559-yc8q62z8	135	19	lost	lose	VBN
cord-295559-yc8q62z8	135	20	the	the	DT
cord-295559-yc8q62z8	135	21	ability	ability	NN
cord-295559-yc8q62z8	135	22	to	to	TO
cord-295559-yc8q62z8	135	23	transduce	transduce	VB
cord-295559-yc8q62z8	135	24	susceptible	susceptible	JJ
cord-295559-yc8q62z8	135	25	cells	cell	NNS
cord-295559-yc8q62z8	135	26	.	.	.
cord-295559-yc8q62z8	136	1	We	-PRON-	PRP
cord-295559-yc8q62z8	136	2	postulate	postulate	VBP
cord-295559-yc8q62z8	136	3	that	that	IN
cord-295559-yc8q62z8	136	4	the	the	DT
cord-295559-yc8q62z8	136	5	MERS	MERS	NNP
cord-295559-yc8q62z8	136	6	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	136	7	that	that	WDT
cord-295559-yc8q62z8	136	8	contain	contain	VBP
cord-295559-yc8q62z8	136	9	large	large	JJ
cord-295559-yc8q62z8	136	10	amounts	amount	NNS
cord-295559-yc8q62z8	136	11	of	of	IN
cord-295559-yc8q62z8	136	12	cleaved	cleaved	JJ
cord-295559-yc8q62z8	136	13	S	S	NNP
cord-295559-yc8q62z8	136	14	protein	protein	NN
cord-295559-yc8q62z8	136	15	,	,	,
cord-295559-yc8q62z8	136	16	detected	detect	VBN
cord-295559-yc8q62z8	136	17	by	by	IN
cord-295559-yc8q62z8	136	18	a	a	DT
cord-295559-yc8q62z8	136	19	c	c	NN
cord-295559-yc8q62z8	136	20	-	-	HYPH
cord-295559-yc8q62z8	136	21	terminal	terminal	NN
cord-295559-yc8q62z8	136	22	tag	tag	NN
cord-295559-yc8q62z8	136	23	[	[	-LRB-
cord-295559-yc8q62z8	136	24	33	33	CD
cord-295559-yc8q62z8	136	25	,	,	,
cord-295559-yc8q62z8	136	26	53	53	CD
cord-295559-yc8q62z8	136	27	]	]	-RRB-
cord-295559-yc8q62z8	136	28	,	,	,
cord-295559-yc8q62z8	136	29	could	could	MD
cord-295559-yc8q62z8	136	30	not	not	RB
cord-295559-yc8q62z8	136	31	enter	enter	VB
cord-295559-yc8q62z8	136	32	cells	cell	NNS
cord-295559-yc8q62z8	136	33	at	at	IN
cord-295559-yc8q62z8	136	34	the	the	DT
cord-295559-yc8q62z8	136	35	plasma	plasma	NN
cord-295559-yc8q62z8	136	36	membrane	membrane	NN
cord-295559-yc8q62z8	136	37	because	because	IN
cord-295559-yc8q62z8	136	38	S1	S1	NNP
cord-295559-yc8q62z8	136	39	may	may	MD
cord-295559-yc8q62z8	136	40	have	have	VB
cord-295559-yc8q62z8	136	41	dissociated	dissociate	VBN
cord-295559-yc8q62z8	136	42	from	from	IN
cord-295559-yc8q62z8	136	43	the	the	DT
cord-295559-yc8q62z8	136	44	cleaved	cleaved	JJ
cord-295559-yc8q62z8	136	45	spikes	spike	NNS
cord-295559-yc8q62z8	136	46	on	on	IN
cord-295559-yc8q62z8	136	47	virions	virion	NNS
cord-295559-yc8q62z8	136	48	.	.	.
cord-295559-yc8q62z8	137	1	Development	development	NN
cord-295559-yc8q62z8	137	2	of	of	IN
cord-295559-yc8q62z8	137	3	antibodies	antibody	NNS
cord-295559-yc8q62z8	137	4	specific	specific	JJ
cord-295559-yc8q62z8	137	5	for	for	IN
cord-295559-yc8q62z8	137	6	the	the	DT
cord-295559-yc8q62z8	137	7	S1	S1	NNP
cord-295559-yc8q62z8	137	8	domain	domain	NN
cord-295559-yc8q62z8	137	9	of	of	IN
cord-295559-yc8q62z8	137	10	MERS	MERS	NNP
cord-295559-yc8q62z8	137	11	S	S	NNP
cord-295559-yc8q62z8	137	12	protein	protein	NN
cord-295559-yc8q62z8	137	13	are	be	VBP
cord-295559-yc8q62z8	137	14	needed	need	VBN
cord-295559-yc8q62z8	137	15	to	to	TO
cord-295559-yc8q62z8	137	16	test	test	VB
cord-295559-yc8q62z8	137	17	this	this	DT
cord-295559-yc8q62z8	137	18	hypothesis	hypothesis	NN
cord-295559-yc8q62z8	137	19	.	.	.
cord-295559-yc8q62z8	138	1	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	138	2	S	S	NNP
cord-295559-yc8q62z8	138	3	proteins	protein	NNS
cord-295559-yc8q62z8	138	4	expressed	express	VBN
cord-295559-yc8q62z8	138	5	on	on	IN
cord-295559-yc8q62z8	138	6	cell	cell	NN
cord-295559-yc8q62z8	138	7	membranes	membrane	NNS
cord-295559-yc8q62z8	138	8	can	can	MD
cord-295559-yc8q62z8	138	9	trigger	trigger	VB
cord-295559-yc8q62z8	138	10	receptor	receptor	NN
cord-295559-yc8q62z8	138	11	-	-	HYPH
cord-295559-yc8q62z8	138	12	dependent	dependent	JJ
cord-295559-yc8q62z8	138	13	syncytia	syncytia	NN
cord-295559-yc8q62z8	138	14	formation	formation	NN
cord-295559-yc8q62z8	138	15	if	if	IN
cord-295559-yc8q62z8	138	16	the	the	DT
cord-295559-yc8q62z8	138	17	membranebound	membranebound	NN
cord-295559-yc8q62z8	138	18	S	S	NNP
cord-295559-yc8q62z8	138	19	protein	protein	NN
cord-295559-yc8q62z8	138	20	is	be	VBZ
cord-295559-yc8q62z8	138	21	cleaved	cleave	VBN
cord-295559-yc8q62z8	138	22	within	within	IN
cord-295559-yc8q62z8	138	23	the	the	DT
cord-295559-yc8q62z8	138	24	infected	infected	JJ
cord-295559-yc8q62z8	138	25	cells	cell	NNS
cord-295559-yc8q62z8	138	26	by	by	IN
cord-295559-yc8q62z8	138	27	furin	furin	NN
cord-295559-yc8q62z8	138	28	or	or	CC
cord-295559-yc8q62z8	138	29	other	other	JJ
cord-295559-yc8q62z8	138	30	proteases	protease	NNS
cord-295559-yc8q62z8	138	31	.	.	.
cord-295559-yc8q62z8	139	1	MERS	MERS	NNP
cord-295559-yc8q62z8	139	2	-	-	HYPH
cord-295559-yc8q62z8	139	3	CoV	cov	NN
cord-295559-yc8q62z8	139	4	infection	infection	NN
cord-295559-yc8q62z8	139	5	of	of	IN
cord-295559-yc8q62z8	139	6	Calu-3	Calu-3	NNP
cord-295559-yc8q62z8	139	7	and	and	CC
cord-295559-yc8q62z8	139	8	Caco-2	Caco-2	NNP
cord-295559-yc8q62z8	139	9	cell	cell	NN
cord-295559-yc8q62z8	139	10	lines	line	NNS
cord-295559-yc8q62z8	139	11	induced	induce	VBN
cord-295559-yc8q62z8	139	12	syncytia	syncytia	NN
cord-295559-yc8q62z8	139	13	formation	formation	NN
cord-295559-yc8q62z8	139	14	[	[	-LRB-
cord-295559-yc8q62z8	139	15	35	35	CD
cord-295559-yc8q62z8	139	16	]	]	-RRB-
cord-295559-yc8q62z8	139	17	.	.	.
cord-295559-yc8q62z8	140	1	Our	-PRON-	PRP$
cord-295559-yc8q62z8	140	2	293	293	CD
cord-295559-yc8q62z8	140	3	T	t	NN
cord-295559-yc8q62z8	140	4	cells	cell	NNS
cord-295559-yc8q62z8	140	5	were	be	VBD
cord-295559-yc8q62z8	140	6	only	only	RB
cord-295559-yc8q62z8	140	7	minimally	minimally	RB
cord-295559-yc8q62z8	140	8	susceptible	susceptible	JJ
cord-295559-yc8q62z8	140	9	to	to	IN
cord-295559-yc8q62z8	140	10	entry	entry	NN
cord-295559-yc8q62z8	140	11	of	of	IN
cord-295559-yc8q62z8	140	12	MERS	MERS	NNP
cord-295559-yc8q62z8	140	13	-	-	HYPH
cord-295559-yc8q62z8	140	14	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	140	15	,	,	,
cord-295559-yc8q62z8	140	16	and	and	CC
cord-295559-yc8q62z8	140	17	did	do	VBD
cord-295559-yc8q62z8	140	18	not	not	RB
cord-295559-yc8q62z8	140	19	form	form	VB
cord-295559-yc8q62z8	140	20	syncytia	syncytia	NN
cord-295559-yc8q62z8	140	21	when	when	WRB
cord-295559-yc8q62z8	140	22	producing	produce	VBG
cord-295559-yc8q62z8	140	23	MERS	MERS	NNP
cord-295559-yc8q62z8	140	24	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	140	25	with	with	IN
cord-295559-yc8q62z8	140	26	uncleaved	uncleaved	JJ
cord-295559-yc8q62z8	140	27	S.	S.	NNP
cord-295559-yc8q62z8	141	1	However	however	RB
cord-295559-yc8q62z8	141	2	,	,	,
cord-295559-yc8q62z8	141	3	when	when	WRB
cord-295559-yc8q62z8	141	4	293	293	CD
cord-295559-yc8q62z8	141	5	T	t	NN
cord-295559-yc8q62z8	141	6	cells	cell	NNS
cord-295559-yc8q62z8	141	7	expressing	express	VBG
cord-295559-yc8q62z8	141	8	MERS	MERS	NNP
cord-295559-yc8q62z8	141	9	-	-	HYPH
cord-295559-yc8q62z8	141	10	CoV	cov	NN
cord-295559-yc8q62z8	141	11	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	141	12	protein	protein	NN
cord-295559-yc8q62z8	141	13	were	be	VBD
cord-295559-yc8q62z8	141	14	co	co	JJ
cord-295559-yc8q62z8	141	15	-	-	JJ
cord-295559-yc8q62z8	141	16	cultured	cultured	JJ
cord-295559-yc8q62z8	141	17	in	in	IN
cord-295559-yc8q62z8	141	18	the	the	DT
cord-295559-yc8q62z8	141	19	presence	presence	NN
cord-295559-yc8q62z8	141	20	of	of	IN
cord-295559-yc8q62z8	141	21	trypsin	trypsin	NN
cord-295559-yc8q62z8	141	22	with	with	IN
cord-295559-yc8q62z8	141	23	Vero	Vero	NNP
cord-295559-yc8q62z8	141	24	E6	E6	NNP
cord-295559-yc8q62z8	141	25	cells	cell	NNS
cord-295559-yc8q62z8	141	26	that	that	WDT
cord-295559-yc8q62z8	141	27	express	express	VBP
cord-295559-yc8q62z8	141	28	the	the	DT
cord-295559-yc8q62z8	141	29	MERS	MERS	NNP
cord-295559-yc8q62z8	141	30	-	-	HYPH
cord-295559-yc8q62z8	141	31	CoV	CoV	NNP
cord-295559-yc8q62z8	141	32	receptor	receptor	NN
cord-295559-yc8q62z8	141	33	,	,	,
cord-295559-yc8q62z8	141	34	enormous	enormous	JJ
cord-295559-yc8q62z8	141	35	syncytia	syncytia	NN
cord-295559-yc8q62z8	141	36	formed	form	VBN
cord-295559-yc8q62z8	141	37	.	.	.
cord-295559-yc8q62z8	142	1	These	these	DT
cord-295559-yc8q62z8	142	2	observations	observation	NNS
cord-295559-yc8q62z8	142	3	suggest	suggest	VBP
cord-295559-yc8q62z8	142	4	that	that	IN
cord-295559-yc8q62z8	142	5	in	in	IN
cord-295559-yc8q62z8	142	6	tissues	tissue	NNS
cord-295559-yc8q62z8	142	7	such	such	JJ
cord-295559-yc8q62z8	142	8	as	as	IN
cord-295559-yc8q62z8	142	9	the	the	DT
cord-295559-yc8q62z8	142	10	lung	lung	NN
cord-295559-yc8q62z8	142	11	,	,	,
cord-295559-yc8q62z8	142	12	where	where	WRB
cord-295559-yc8q62z8	142	13	trypsin	trypsin	NN
cord-295559-yc8q62z8	142	14	,	,	,
cord-295559-yc8q62z8	142	15	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	142	16	or	or	CC
cord-295559-yc8q62z8	142	17	-4	-4	NNP
cord-295559-yc8q62z8	142	18	and	and	CC
cord-295559-yc8q62z8	142	19	HAT	hat	NN
cord-295559-yc8q62z8	142	20	and	and	CC
cord-295559-yc8q62z8	142	21	other	other	JJ
cord-295559-yc8q62z8	142	22	serine	serine	NN
cord-295559-yc8q62z8	142	23	proteases	protease	NNS
cord-295559-yc8q62z8	142	24	are	be	VBP
cord-295559-yc8q62z8	142	25	available	available	JJ
cord-295559-yc8q62z8	142	26	,	,	,
cord-295559-yc8q62z8	142	27	MERS	MERS	NNP
cord-295559-yc8q62z8	142	28	-	-	HYPH
cord-295559-yc8q62z8	142	29	CoV	CoV	NNP
cord-295559-yc8q62z8	142	30	virus	virus	NN
cord-295559-yc8q62z8	142	31	infection	infection	NN
cord-295559-yc8q62z8	142	32	might	may	MD
cord-295559-yc8q62z8	142	33	spread	spread	VB
cord-295559-yc8q62z8	142	34	directly	directly	RB
cord-295559-yc8q62z8	142	35	from	from	IN
cord-295559-yc8q62z8	142	36	cell	cell	NN
cord-295559-yc8q62z8	142	37	to	to	IN
cord-295559-yc8q62z8	142	38	cell	cell	NN
cord-295559-yc8q62z8	142	39	by	by	IN
cord-295559-yc8q62z8	142	40	S	s	NN
cord-295559-yc8q62z8	142	41	-	-	HYPH
cord-295559-yc8q62z8	142	42	mediated	mediate	VBN
cord-295559-yc8q62z8	142	43	,	,	,
cord-295559-yc8q62z8	142	44	receptor	receptor	NN
cord-295559-yc8q62z8	142	45	-	-	HYPH
cord-295559-yc8q62z8	142	46	dependent	dependent	JJ
cord-295559-yc8q62z8	142	47	syncytia	syncytia	NN
cord-295559-yc8q62z8	142	48	formation	formation	NN
cord-295559-yc8q62z8	142	49	,	,	,
cord-295559-yc8q62z8	142	50	potentially	potentially	RB
cord-295559-yc8q62z8	142	51	escaping	escape	VBG
cord-295559-yc8q62z8	142	52	from	from	IN
cord-295559-yc8q62z8	142	53	virus	virus	NN
cord-295559-yc8q62z8	142	54	-	-	HYPH
cord-295559-yc8q62z8	142	55	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	142	56	antibodies	antibody	NNS
cord-295559-yc8q62z8	142	57	,	,	,
cord-295559-yc8q62z8	142	58	as	as	IN
cord-295559-yc8q62z8	142	59	do	do	VBP
cord-295559-yc8q62z8	142	60	other	other	JJ
cord-295559-yc8q62z8	142	61	syncytia	syncytia	NN
cord-295559-yc8q62z8	142	62	-	-	HYPH
cord-295559-yc8q62z8	142	63	forming	form	VBG
cord-295559-yc8q62z8	142	64	viruses	virus	NNS
cord-295559-yc8q62z8	142	65	such	such	JJ
cord-295559-yc8q62z8	142	66	as	as	IN
cord-295559-yc8q62z8	142	67	respiratory	respiratory	JJ
cord-295559-yc8q62z8	142	68	syncytial	syncytial	JJ
cord-295559-yc8q62z8	142	69	virus	virus	NN
cord-295559-yc8q62z8	142	70	,	,	,
cord-295559-yc8q62z8	142	71	parainfluenza	parainfluenza	NNP
cord-295559-yc8q62z8	142	72	viruses	virus	NNS
cord-295559-yc8q62z8	142	73	,	,	,
cord-295559-yc8q62z8	142	74	and	and	CC
cord-295559-yc8q62z8	142	75	measles	measle	NNS
cord-295559-yc8q62z8	142	76	.	.	.
cord-295559-yc8q62z8	143	1	It	-PRON-	PRP
cord-295559-yc8q62z8	143	2	will	will	MD
cord-295559-yc8q62z8	143	3	be	be	VB
cord-295559-yc8q62z8	143	4	important	important	JJ
cord-295559-yc8q62z8	143	5	to	to	TO
cord-295559-yc8q62z8	143	6	learn	learn	VB
cord-295559-yc8q62z8	143	7	whether	whether	IN
cord-295559-yc8q62z8	143	8	syncytia	syncytia	NN
cord-295559-yc8q62z8	143	9	are	be	VBP
cord-295559-yc8q62z8	143	10	formed	form	VBN
cord-295559-yc8q62z8	143	11	in	in	IN
cord-295559-yc8q62z8	143	12	lungs	lung	NNS
cord-295559-yc8q62z8	143	13	or	or	CC
cord-295559-yc8q62z8	143	14	other	other	JJ
cord-295559-yc8q62z8	143	15	tissues	tissue	NNS
cord-295559-yc8q62z8	143	16	of	of	IN
cord-295559-yc8q62z8	143	17	MERS	MERS	NNP
cord-295559-yc8q62z8	143	18	-	-	HYPH
cord-295559-yc8q62z8	143	19	CoV	cov	NN
cord-295559-yc8q62z8	143	20	patients	patient	NNS
cord-295559-yc8q62z8	143	21	or	or	CC
cord-295559-yc8q62z8	143	22	animal	animal	NN
cord-295559-yc8q62z8	143	23	models	model	NNS
cord-295559-yc8q62z8	143	24	of	of	IN
cord-295559-yc8q62z8	143	25	MERS	MERS	NNP
cord-295559-yc8q62z8	144	1	-CoV.	-cov.	ADD
cord-295559-yc8q62z8	145	1	Some	some	DT
cord-295559-yc8q62z8	145	2	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	145	3	S	s	NN
cord-295559-yc8q62z8	145	4	proteins	protein	NNS
cord-295559-yc8q62z8	145	5	can	can	MD
cord-295559-yc8q62z8	145	6	also	also	RB
cord-295559-yc8q62z8	145	7	trigger	trigger	VB
cord-295559-yc8q62z8	145	8	receptorindependent	receptorindependent	NN
cord-295559-yc8q62z8	145	9	syncytia	syncytia	NN
cord-295559-yc8q62z8	145	10	formation	formation	NN
cord-295559-yc8q62z8	145	11	[	[	-LRB-
cord-295559-yc8q62z8	145	12	61	61	CD
cord-295559-yc8q62z8	145	13	,	,	,
cord-295559-yc8q62z8	145	14	62	62	CD
cord-295559-yc8q62z8	145	15	]	]	-RRB-
cord-295559-yc8q62z8	145	16	.	.	.
cord-295559-yc8q62z8	146	1	When	when	WRB
cord-295559-yc8q62z8	146	2	S	s	NN
cord-295559-yc8q62z8	146	3	proteins	protein	NNS
cord-295559-yc8q62z8	146	4	expressed	express	VBN
cord-295559-yc8q62z8	146	5	on	on	IN
cord-295559-yc8q62z8	146	6	the	the	DT
cord-295559-yc8q62z8	146	7	plasma	plasma	NN
cord-295559-yc8q62z8	146	8	membrane	membrane	NN
cord-295559-yc8q62z8	146	9	are	be	VBP
cord-295559-yc8q62z8	146	10	cleaved	cleave	VBN
cord-295559-yc8q62z8	146	11	,	,	,
cord-295559-yc8q62z8	146	12	the	the	DT
cord-295559-yc8q62z8	146	13	S1	s1	NN
cord-295559-yc8q62z8	146	14	domain	domain	NN
cord-295559-yc8q62z8	146	15	can	can	MD
cord-295559-yc8q62z8	146	16	detach	detach	VB
cord-295559-yc8q62z8	146	17	from	from	IN
cord-295559-yc8q62z8	146	18	the	the	DT
cord-295559-yc8q62z8	146	19	spike	spike	NN
cord-295559-yc8q62z8	146	20	,	,	,
cord-295559-yc8q62z8	146	21	exposing	expose	VBG
cord-295559-yc8q62z8	146	22	the	the	DT
cord-295559-yc8q62z8	146	23	hydrophobic	hydrophobic	JJ
cord-295559-yc8q62z8	146	24	fusion	fusion	NN
cord-295559-yc8q62z8	146	25	peptide	peptide	NN
cord-295559-yc8q62z8	146	26	of	of	IN
cord-295559-yc8q62z8	146	27	the	the	DT
cord-295559-yc8q62z8	146	28	membrane	membrane	NN
cord-295559-yc8q62z8	146	29	-	-	HYPH
cord-295559-yc8q62z8	146	30	anchored	anchor	VBN
cord-295559-yc8q62z8	146	31	S2	s2	NN
cord-295559-yc8q62z8	146	32	domain	domain	NN
cord-295559-yc8q62z8	146	33	that	that	WDT
cord-295559-yc8q62z8	146	34	can	can	MD
cord-295559-yc8q62z8	146	35	directly	directly	RB
cord-295559-yc8q62z8	146	36	induce	induce	VB
cord-295559-yc8q62z8	146	37	fusion	fusion	NN
cord-295559-yc8q62z8	146	38	with	with	IN
cord-295559-yc8q62z8	146	39	any	any	DT
cord-295559-yc8q62z8	146	40	nearby	nearby	JJ
cord-295559-yc8q62z8	146	41	cell	cell	NN
cord-295559-yc8q62z8	146	42	membranes	membrane	NNS
cord-295559-yc8q62z8	146	43	or	or	CC
cord-295559-yc8q62z8	146	44	lipid	lipid	NN
cord-295559-yc8q62z8	146	45	bilayers	bilayer	NNS
cord-295559-yc8q62z8	146	46	even	even	RB
cord-295559-yc8q62z8	146	47	if	if	IN
cord-295559-yc8q62z8	146	48	they	-PRON-	PRP
cord-295559-yc8q62z8	146	49	lack	lack	VBP
cord-295559-yc8q62z8	146	50	receptors	receptor	NNS
cord-295559-yc8q62z8	146	51	.	.	.
cord-295559-yc8q62z8	147	1	This	this	DT
cord-295559-yc8q62z8	147	2	"	"	``
cord-295559-yc8q62z8	147	3	receptor	receptor	NN
cord-295559-yc8q62z8	147	4	-	-	HYPH
cord-295559-yc8q62z8	147	5	independent	independent	JJ
cord-295559-yc8q62z8	147	6	spread	spread	NN
cord-295559-yc8q62z8	147	7	(	(	-LRB-
cord-295559-yc8q62z8	147	8	RIS	RIS	NNP
cord-295559-yc8q62z8	147	9	)	)	-RRB-
cord-295559-yc8q62z8	147	10	"	"	``
cord-295559-yc8q62z8	147	11	allows	allow	VBZ
cord-295559-yc8q62z8	147	12	an	an	DT
cord-295559-yc8q62z8	147	13	infected	infected	JJ
cord-295559-yc8q62z8	147	14	cell	cell	NN
cord-295559-yc8q62z8	147	15	to	to	TO
cord-295559-yc8q62z8	147	16	fuse	fuse	VB
cord-295559-yc8q62z8	147	17	with	with	IN
cord-295559-yc8q62z8	147	18	adjacent	adjacent	JJ
cord-295559-yc8q62z8	147	19	noninfected	noninfected	JJ
cord-295559-yc8q62z8	147	20	,	,	,
cord-295559-yc8q62z8	147	21	receptor	receptor	NN
cord-295559-yc8q62z8	147	22	-	-	HYPH
cord-295559-yc8q62z8	147	23	negative	negative	JJ
cord-295559-yc8q62z8	147	24	cells	cell	NNS
cord-295559-yc8q62z8	147	25	that	that	WDT
cord-295559-yc8q62z8	147	26	can	can	MD
cord-295559-yc8q62z8	147	27	,	,	,
cord-295559-yc8q62z8	147	28	in	in	IN
cord-295559-yc8q62z8	147	29	turn	turn	NN
cord-295559-yc8q62z8	147	30	,	,	,
cord-295559-yc8q62z8	147	31	produce	produce	VBP
cord-295559-yc8q62z8	147	32	virus	virus	NN
cord-295559-yc8q62z8	147	33	and	and	CC
cord-295559-yc8q62z8	147	34	fuse	fuse	VB
cord-295559-yc8q62z8	147	35	with	with	IN
cord-295559-yc8q62z8	147	36	additional	additional	JJ
cord-295559-yc8q62z8	147	37	receptor	receptor	NN
cord-295559-yc8q62z8	147	38	-	-	HYPH
cord-295559-yc8q62z8	147	39	negative	negative	JJ
cord-295559-yc8q62z8	147	40	cells	cell	NNS
cord-295559-yc8q62z8	147	41	.	.	.
cord-295559-yc8q62z8	148	1	RIS	RIS	NNP
cord-295559-yc8q62z8	148	2	activity	activity	NN
cord-295559-yc8q62z8	148	3	depends	depend	VBZ
cord-295559-yc8q62z8	148	4	on	on	IN
cord-295559-yc8q62z8	148	5	the	the	DT
cord-295559-yc8q62z8	148	6	stability	stability	NN
cord-295559-yc8q62z8	148	7	of	of	IN
cord-295559-yc8q62z8	148	8	S1	S1	NNP
cord-295559-yc8q62z8	148	9	/	/	SYM
cord-295559-yc8q62z8	148	10	S2	S2	NNP
cord-295559-yc8q62z8	148	11	interactions	interaction	NNS
cord-295559-yc8q62z8	148	12	,	,	,
cord-295559-yc8q62z8	148	13	and	and	CC
cord-295559-yc8q62z8	148	14	low	low	JJ
cord-295559-yc8q62z8	148	15	stability	stability	NN
cord-295559-yc8q62z8	148	16	of	of	IN
cord-295559-yc8q62z8	148	17	S1	s1	NN
cord-295559-yc8q62z8	148	18	/	/	SYM
cord-295559-yc8q62z8	148	19	S2	S2	NNP
cord-295559-yc8q62z8	148	20	heterodimers	heterodimer	NNS
cord-295559-yc8q62z8	148	21	correlates	correlate	VBZ
cord-295559-yc8q62z8	148	22	with	with	IN
cord-295559-yc8q62z8	148	23	rapid	rapid	JJ
cord-295559-yc8q62z8	148	24	spread	spread	NN
cord-295559-yc8q62z8	148	25	of	of	IN
cord-295559-yc8q62z8	148	26	infection	infection	NN
cord-295559-yc8q62z8	148	27	through	through	IN
cord-295559-yc8q62z8	148	28	tissues	tissue	NNS
cord-295559-yc8q62z8	148	29	that	that	WDT
cord-295559-yc8q62z8	148	30	express	express	VBP
cord-295559-yc8q62z8	148	31	little	little	JJ
cord-295559-yc8q62z8	148	32	receptor	receptor	NN
cord-295559-yc8q62z8	148	33	protein	protein	NN
cord-295559-yc8q62z8	148	34	[	[	-LRB-
cord-295559-yc8q62z8	148	35	63	63	CD
cord-295559-yc8q62z8	148	36	,	,	,
cord-295559-yc8q62z8	148	37	64	64	CD
cord-295559-yc8q62z8	148	38	]	]	-RRB-
cord-295559-yc8q62z8	148	39	.	.	.
cord-295559-yc8q62z8	149	1	We	-PRON-	PRP
cord-295559-yc8q62z8	149	2	found	find	VBD
cord-295559-yc8q62z8	149	3	that	that	IN
cord-295559-yc8q62z8	149	4	transmembrane	transmembrane	NN
cord-295559-yc8q62z8	149	5	serine	serine	NN
cord-295559-yc8q62z8	149	6	proteases	protease	NNS
cord-295559-yc8q62z8	149	7	TMPRSS-2	tmprss-2	CD
cord-295559-yc8q62z8	149	8	and	and	CC
cord-295559-yc8q62z8	149	9	-4	-4	NNP
cord-295559-yc8q62z8	149	10	could	could	MD
cord-295559-yc8q62z8	149	11	activate	activate	VB
cord-295559-yc8q62z8	149	12	the	the	DT
cord-295559-yc8q62z8	149	13	syncytia	syncytia	NN
cord-295559-yc8q62z8	149	14	forming	form	VBG
cord-295559-yc8q62z8	149	15	activity	activity	NN
cord-295559-yc8q62z8	149	16	of	of	IN
cord-295559-yc8q62z8	149	17	MERS	MERS	NNP
cord-295559-yc8q62z8	149	18	-	-	HYPH
cord-295559-yc8q62z8	149	19	CoV	cov	NN
cord-295559-yc8q62z8	149	20	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	149	21	protein	protein	NN
cord-295559-yc8q62z8	149	22	expressed	express	VBD
cord-295559-yc8q62z8	149	23	in	in	IN
cord-295559-yc8q62z8	149	24	293	293	CD
cord-295559-yc8q62z8	149	25	T	t	NN
cord-295559-yc8q62z8	149	26	cells	cell	NNS
cord-295559-yc8q62z8	149	27	as	as	IN
cord-295559-yc8q62z8	149	28	these	these	DT
cord-295559-yc8q62z8	149	29	proteases	protease	NNS
cord-295559-yc8q62z8	149	30	do	do	VBP
cord-295559-yc8q62z8	149	31	for	for	IN
cord-295559-yc8q62z8	149	32	Class	class	NN
cord-295559-yc8q62z8	149	33	1	1	CD
cord-295559-yc8q62z8	149	34	fusion	fusion	NN
cord-295559-yc8q62z8	149	35	proteins	protein	NNS
cord-295559-yc8q62z8	149	36	of	of	IN
cord-295559-yc8q62z8	149	37	other	other	JJ
cord-295559-yc8q62z8	149	38	respiratory	respiratory	JJ
cord-295559-yc8q62z8	149	39	viruses	virus	NNS
cord-295559-yc8q62z8	149	40	including	include	VBG
cord-295559-yc8q62z8	149	41	influenza	influenza	NN
cord-295559-yc8q62z8	149	42	,	,	,
cord-295559-yc8q62z8	149	43	SARS	SARS	NNP
cord-295559-yc8q62z8	149	44	-	-	HYPH
cord-295559-yc8q62z8	149	45	CoV	CoV	NNP
cord-295559-yc8q62z8	149	46	and	and	CC
cord-295559-yc8q62z8	149	47	human	human	NN
cord-295559-yc8q62z8	149	48	metapneumovirus	metapneumovirus	NNP
cord-295559-yc8q62z8	149	49	[	[	-LRB-
cord-295559-yc8q62z8	149	50	19	19	CD
cord-295559-yc8q62z8	149	51	,	,	,
cord-295559-yc8q62z8	149	52	20	20	CD
cord-295559-yc8q62z8	149	53	,	,	,
cord-295559-yc8q62z8	149	54	[	[	-LRB-
cord-295559-yc8q62z8	149	55	42	42	CD
cord-295559-yc8q62z8	149	56	]	]	-RRB-
cord-295559-yc8q62z8	150	1	[	[	-LRB-
cord-295559-yc8q62z8	150	2	43	43	CD
cord-295559-yc8q62z8	150	3	]	]	-RRB-
cord-295559-yc8q62z8	150	4	[	[	-LRB-
cord-295559-yc8q62z8	150	5	44	44	CD
cord-295559-yc8q62z8	150	6	]	]	-RRB-
cord-295559-yc8q62z8	150	7	[	[	-LRB-
cord-295559-yc8q62z8	150	8	45	45	CD
cord-295559-yc8q62z8	150	9	]	]	-RRB-
cord-295559-yc8q62z8	150	10	.	.	.
cord-295559-yc8q62z8	151	1	We	-PRON-	PRP
cord-295559-yc8q62z8	151	2	were	be	VBD
cord-295559-yc8q62z8	151	3	surprised	surprised	JJ
cord-295559-yc8q62z8	151	4	that	that	IN
cord-295559-yc8q62z8	151	5	293	293	CD
cord-295559-yc8q62z8	151	6	T	t	NN
cord-295559-yc8q62z8	151	7	cells	cell	NNS
cord-295559-yc8q62z8	151	8	,	,	,
cord-295559-yc8q62z8	151	9	which	which	WDT
cord-295559-yc8q62z8	151	10	express	express	VBP
cord-295559-yc8q62z8	151	11	very	very	RB
cord-295559-yc8q62z8	151	12	little	little	JJ
cord-295559-yc8q62z8	151	13	MERS	MERS	NNP
cord-295559-yc8q62z8	151	14	-	-	HYPH
cord-295559-yc8q62z8	151	15	CoV	CoV	NNP
cord-295559-yc8q62z8	151	16	receptor	receptor	NN
cord-295559-yc8q62z8	151	17	,	,	,
cord-295559-yc8q62z8	151	18	were	be	VBD
cord-295559-yc8q62z8	151	19	so	so	RB
cord-295559-yc8q62z8	151	20	extensively	extensively	RB
cord-295559-yc8q62z8	151	21	fused	fuse	VBN
cord-295559-yc8q62z8	151	22	,	,	,
cord-295559-yc8q62z8	151	23	and	and	CC
cord-295559-yc8q62z8	151	24	we	-PRON-	PRP
cord-295559-yc8q62z8	151	25	hypothesize	hypothesize	VBP
cord-295559-yc8q62z8	151	26	that	that	IN
cord-295559-yc8q62z8	151	27	this	this	DT
cord-295559-yc8q62z8	151	28	syncytia	syncytia	NN
cord-295559-yc8q62z8	151	29	formation	formation	NN
cord-295559-yc8q62z8	151	30	may	may	MD
cord-295559-yc8q62z8	151	31	be	be	VB
cord-295559-yc8q62z8	151	32	due	due	JJ
cord-295559-yc8q62z8	151	33	to	to	IN
cord-295559-yc8q62z8	151	34	RIS	RIS	NNP
cord-295559-yc8q62z8	151	35	.	.	.
cord-295559-yc8q62z8	152	1	Due	due	IN
cord-295559-yc8q62z8	152	2	to	to	IN
cord-295559-yc8q62z8	152	3	its	-PRON-	PRP$
cord-295559-yc8q62z8	152	4	high	high	JJ
cord-295559-yc8q62z8	152	5	case	case	NN
cord-295559-yc8q62z8	152	6	fatality	fatality	NN
cord-295559-yc8q62z8	152	7	rate	rate	NN
cord-295559-yc8q62z8	152	8	,	,	,
cord-295559-yc8q62z8	152	9	therapeutic	therapeutic	JJ
cord-295559-yc8q62z8	152	10	interventions	intervention	NNS
cord-295559-yc8q62z8	152	11	for	for	IN
cord-295559-yc8q62z8	152	12	MERS	MERS	NNP
cord-295559-yc8q62z8	152	13	-	-	HYPH
cord-295559-yc8q62z8	152	14	CoV	CoV	NNP
cord-295559-yc8q62z8	152	15	are	be	VBP
cord-295559-yc8q62z8	152	16	urgently	urgently	RB
cord-295559-yc8q62z8	152	17	needed	need	VBN
cord-295559-yc8q62z8	152	18	.	.	.
cord-295559-yc8q62z8	153	1	Pooled	pool	VBN
cord-295559-yc8q62z8	153	2	purified	purify	VBN
cord-295559-yc8q62z8	153	3	human	human	JJ
cord-295559-yc8q62z8	153	4	immunoglobulin	immunoglobulin	NN
cord-295559-yc8q62z8	153	5	containing	contain	VBG
cord-295559-yc8q62z8	153	6	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	153	7	antibody	antibody	NN
cord-295559-yc8q62z8	153	8	has	have	VBZ
cord-295559-yc8q62z8	153	9	been	be	VBN
cord-295559-yc8q62z8	153	10	used	use	VBN
cord-295559-yc8q62z8	153	11	to	to	TO
cord-295559-yc8q62z8	153	12	treat	treat	VB
cord-295559-yc8q62z8	153	13	a	a	DT
cord-295559-yc8q62z8	153	14	variety	variety	NN
cord-295559-yc8q62z8	153	15	of	of	IN
cord-295559-yc8q62z8	153	16	infectious	infectious	JJ
cord-295559-yc8q62z8	153	17	diseases	disease	NNS
cord-295559-yc8q62z8	153	18	.	.	.
cord-295559-yc8q62z8	154	1	Not	not	RB
cord-295559-yc8q62z8	154	2	surprisingly	surprisingly	RB
cord-295559-yc8q62z8	154	3	,	,	,
cord-295559-yc8q62z8	154	4	since	since	IN
cord-295559-yc8q62z8	154	5	MERS	MERS	NNP
cord-295559-yc8q62z8	154	6	-	-	HYPH
cord-295559-yc8q62z8	154	7	CoV	CoV	NNP
cord-295559-yc8q62z8	154	8	is	be	VBZ
cord-295559-yc8q62z8	154	9	an	an	DT
cord-295559-yc8q62z8	154	10	emerging	emerge	VBG
cord-295559-yc8q62z8	154	11	pathogen	pathogen	NN
cord-295559-yc8q62z8	154	12	,	,	,
cord-295559-yc8q62z8	154	13	we	-PRON-	PRP
cord-295559-yc8q62z8	154	14	found	find	VBD
cord-295559-yc8q62z8	154	15	that	that	IN
cord-295559-yc8q62z8	154	16	human	human	JJ
cord-295559-yc8q62z8	154	17	immunoglobulin	immunoglobulin	NN
cord-295559-yc8q62z8	154	18	from	from	IN
cord-295559-yc8q62z8	154	19	the	the	DT
cord-295559-yc8q62z8	154	20	USA	USA	NNP
cord-295559-yc8q62z8	154	21	could	could	MD
cord-295559-yc8q62z8	154	22	not	not	RB
cord-295559-yc8q62z8	154	23	neutralize	neutralize	VB
cord-295559-yc8q62z8	154	24	the	the	DT
cord-295559-yc8q62z8	154	25	infectivity	infectivity	NN
cord-295559-yc8q62z8	154	26	of	of	IN
cord-295559-yc8q62z8	154	27	MERS	MERS	NNP
cord-295559-yc8q62z8	154	28	pseudovirions	pseudovirions	NNP
cord-295559-yc8q62z8	154	29	(	(	-LRB-
cord-295559-yc8q62z8	154	30	data	datum	NNS
cord-295559-yc8q62z8	154	31	not	not	RB
cord-295559-yc8q62z8	154	32	shown	show	VBN
cord-295559-yc8q62z8	154	33	)	)	-RRB-
cord-295559-yc8q62z8	154	34	.	.	.
cord-295559-yc8q62z8	155	1	However	however	RB
cord-295559-yc8q62z8	155	2	,	,	,
cord-295559-yc8q62z8	155	3	sera	sera	NNP
cord-295559-yc8q62z8	155	4	from	from	IN
cord-295559-yc8q62z8	155	5	patients	patient	NNS
cord-295559-yc8q62z8	155	6	infected	infect	VBN
cord-295559-yc8q62z8	155	7	with	with	IN
cord-295559-yc8q62z8	155	8	either	either	DT
cord-295559-yc8q62z8	155	9	SARS	SARS	NNP
cord-295559-yc8q62z8	155	10	-	-	HYPH
cord-295559-yc8q62z8	155	11	CoV	CoV	NNP
cord-295559-yc8q62z8	155	12	or	or	CC
cord-295559-yc8q62z8	155	13	MERS	MERS	NNP
cord-295559-yc8q62z8	155	14	-	-	HYPH
cord-295559-yc8q62z8	155	15	CoV	CoV	NNP
cord-295559-yc8q62z8	155	16	contain	contain	VBP
cord-295559-yc8q62z8	155	17	antibodies	antibody	NNS
cord-295559-yc8q62z8	155	18	that	that	WDT
cord-295559-yc8q62z8	155	19	can	can	MD
cord-295559-yc8q62z8	155	20	neutralize	neutralize	VB
cord-295559-yc8q62z8	155	21	MERS	MERS	NNP
cord-295559-yc8q62z8	155	22	-	-	HYPH
cord-295559-yc8q62z8	155	23	CoV	CoV	NNP
cord-295559-yc8q62z8	155	24	[	[	-LRB-
cord-295559-yc8q62z8	155	25	33	33	CD
cord-295559-yc8q62z8	155	26	,	,	,
cord-295559-yc8q62z8	155	27	53	53	CD
cord-295559-yc8q62z8	155	28	]	]	-RRB-
cord-295559-yc8q62z8	155	29	.	.	.
cord-295559-yc8q62z8	156	1	Most	Most	JJS
cord-295559-yc8q62z8	156	2	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	156	3	antibodies	antibody	NNS
cord-295559-yc8q62z8	156	4	would	would	MD
cord-295559-yc8q62z8	156	5	likely	likely	RB
cord-295559-yc8q62z8	156	6	target	target	VB
cord-295559-yc8q62z8	156	7	the	the	DT
cord-295559-yc8q62z8	156	8	receptorbinding	receptorbinde	VBG
cord-295559-yc8q62z8	156	9	S1	S1	NNP
cord-295559-yc8q62z8	156	10	domain	domain	NN
cord-295559-yc8q62z8	156	11	of	of	IN
cord-295559-yc8q62z8	156	12	MERS	MERS	NNP
cord-295559-yc8q62z8	156	13	-	-	HYPH
cord-295559-yc8q62z8	156	14	CoV	CoV	NNP
cord-295559-yc8q62z8	156	15	S	S	NNP
cord-295559-yc8q62z8	156	16	,	,	,
cord-295559-yc8q62z8	156	17	which	which	WDT
cord-295559-yc8q62z8	156	18	is	be	VBZ
cord-295559-yc8q62z8	156	19	less	less	RBR
cord-295559-yc8q62z8	156	20	conserved	conserved	JJ
cord-295559-yc8q62z8	156	21	than	than	IN
cord-295559-yc8q62z8	156	22	the	the	DT
cord-295559-yc8q62z8	156	23	S2	S2	NNP
cord-295559-yc8q62z8	156	24	domain	domain	NN
cord-295559-yc8q62z8	156	25	and	and	CC
cord-295559-yc8q62z8	156	26	can	can	MD
cord-295559-yc8q62z8	156	27	mutate	mutate	VB
cord-295559-yc8q62z8	156	28	,	,	,
cord-295559-yc8q62z8	156	29	likely	likely	RB
cord-295559-yc8q62z8	156	30	generating	generate	VBG
cord-295559-yc8q62z8	156	31	antibody	antibody	NN
cord-295559-yc8q62z8	156	32	escape	escape	NN
cord-295559-yc8q62z8	156	33	mutants	mutant	NNS
cord-295559-yc8q62z8	156	34	[	[	-LRB-
cord-295559-yc8q62z8	156	35	65	65	CD
cord-295559-yc8q62z8	156	36	]	]	-RRB-
cord-295559-yc8q62z8	156	37	.	.	.
cord-295559-yc8q62z8	157	1	Here	here	RB
cord-295559-yc8q62z8	157	2	we	-PRON-	PRP
cord-295559-yc8q62z8	157	3	showed	show	VBD
cord-295559-yc8q62z8	157	4	that	that	IN
cord-295559-yc8q62z8	157	5	a	a	DT
cord-295559-yc8q62z8	157	6	polyclonal	polyclonal	JJ
cord-295559-yc8q62z8	157	7	antibody	antibody	NN
cord-295559-yc8q62z8	157	8	to	to	IN
cord-295559-yc8q62z8	157	9	the	the	DT
cord-295559-yc8q62z8	157	10	S	S	NNP
cord-295559-yc8q62z8	157	11	protein	protein	NN
cord-295559-yc8q62z8	157	12	of	of	IN
cord-295559-yc8q62z8	157	13	MHV	MHV	NNP
cord-295559-yc8q62z8	157	14	,	,	,
cord-295559-yc8q62z8	157	15	a	a	DT
cord-295559-yc8q62z8	157	16	group	group	NN
cord-295559-yc8q62z8	157	17	a	a	DT
cord-295559-yc8q62z8	157	18	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	157	19	,	,	,
cord-295559-yc8q62z8	157	20	cross	cross	NN
cord-295559-yc8q62z8	157	21	reacts	react	VBZ
cord-295559-yc8q62z8	157	22	with	with	IN
cord-295559-yc8q62z8	157	23	the	the	DT
cord-295559-yc8q62z8	157	24	S2	S2	NNP
cord-295559-yc8q62z8	157	25	domain	domain	NN
cord-295559-yc8q62z8	157	26	of	of	IN
cord-295559-yc8q62z8	157	27	MERS	MERS	NNP
cord-295559-yc8q62z8	157	28	S	S	NNP
cord-295559-yc8q62z8	157	29	protein	protein	NN
cord-295559-yc8q62z8	157	30	in	in	IN
cord-295559-yc8q62z8	157	31	immunoblots	immunoblot	NNS
cord-295559-yc8q62z8	157	32	.	.	.
cord-295559-yc8q62z8	158	1	As	as	IN
cord-295559-yc8q62z8	158	2	we	-PRON-	PRP
cord-295559-yc8q62z8	158	3	and	and	CC
cord-295559-yc8q62z8	158	4	others	other	NNS
cord-295559-yc8q62z8	158	5	have	have	VBP
cord-295559-yc8q62z8	158	6	proposed	propose	VBN
cord-295559-yc8q62z8	158	7	for	for	IN
cord-295559-yc8q62z8	158	8	SARS	SARS	NNP
cord-295559-yc8q62z8	158	9	-	-	HYPH
cord-295559-yc8q62z8	158	10	CoVs	CoVs	NNP
cord-295559-yc8q62z8	158	11	[	[	-LRB-
cord-295559-yc8q62z8	158	12	66	66	CD
cord-295559-yc8q62z8	158	13	,	,	,
cord-295559-yc8q62z8	158	14	67	67	CD
cord-295559-yc8q62z8	158	15	]	]	-RRB-
cord-295559-yc8q62z8	158	16	,	,	,
cord-295559-yc8q62z8	158	17	the	the	DT
cord-295559-yc8q62z8	158	18	more	more	RBR
cord-295559-yc8q62z8	158	19	highly	highly	RB
cord-295559-yc8q62z8	158	20	conserved	conserve	VBN
cord-295559-yc8q62z8	158	21	S2	s2	NN
cord-295559-yc8q62z8	158	22	domain	domain	NN
cord-295559-yc8q62z8	158	23	,	,	,
cord-295559-yc8q62z8	158	24	and	and	CC
cord-295559-yc8q62z8	158	25	especially	especially	RB
cord-295559-yc8q62z8	158	26	its	-PRON-	PRP$
cord-295559-yc8q62z8	158	27	C	C	NNP
cord-295559-yc8q62z8	158	28	-	-	HYPH
cord-295559-yc8q62z8	158	29	terminal	terminal	NN
cord-295559-yc8q62z8	158	30	heptad	heptad	NN
cord-295559-yc8q62z8	158	31	repeat	repeat	NN
cord-295559-yc8q62z8	158	32	(	(	-LRB-
cord-295559-yc8q62z8	158	33	HRC	HRC	NNP
cord-295559-yc8q62z8	158	34	)	)	-RRB-
cord-295559-yc8q62z8	158	35	region	region	NN
cord-295559-yc8q62z8	158	36	,	,	,
cord-295559-yc8q62z8	158	37	can	can	MD
cord-295559-yc8q62z8	158	38	be	be	VB
cord-295559-yc8q62z8	158	39	important	important	JJ
cord-295559-yc8q62z8	158	40	targets	target	NNS
cord-295559-yc8q62z8	158	41	for	for	IN
cord-295559-yc8q62z8	158	42	blocking	block	VBG
cord-295559-yc8q62z8	158	43	conformational	conformational	JJ
cord-295559-yc8q62z8	158	44	changes	change	NNS
cord-295559-yc8q62z8	158	45	in	in	IN
cord-295559-yc8q62z8	158	46	S	S	NNP
cord-295559-yc8q62z8	158	47	,	,	,
cord-295559-yc8q62z8	158	48	inhibiting	inhibit	VBG
cord-295559-yc8q62z8	158	49	syncytia	syncytia	NN
cord-295559-yc8q62z8	158	50	formation	formation	NN
cord-295559-yc8q62z8	158	51	and	and	CC
cord-295559-yc8q62z8	158	52	virus	virus	NN
cord-295559-yc8q62z8	158	53	entry	entry	NN
cord-295559-yc8q62z8	158	54	,	,	,
cord-295559-yc8q62z8	158	55	and	and	CC
cord-295559-yc8q62z8	158	56	also	also	RB
cord-295559-yc8q62z8	158	57	eliciting	elicit	VBG
cord-295559-yc8q62z8	158	58	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	158	59	antibodies	antibody	NNS
cord-295559-yc8q62z8	158	60	.	.	.
cord-295559-yc8q62z8	159	1	If	if	IN
cord-295559-yc8q62z8	159	2	MERS	MERS	NNP
cord-295559-yc8q62z8	159	3	-	-	HYPH
cord-295559-yc8q62z8	159	4	CoV	CoV	NNP
cord-295559-yc8q62z8	159	5	virions	virion	NNS
cord-295559-yc8q62z8	159	6	made	make	VBN
cord-295559-yc8q62z8	159	7	in	in	IN
cord-295559-yc8q62z8	159	8	the	the	DT
cord-295559-yc8q62z8	159	9	lung	lung	NN
cord-295559-yc8q62z8	159	10	have	have	VBP
cord-295559-yc8q62z8	159	11	uncleaved	uncleave	VBN
cord-295559-yc8q62z8	159	12	S	S	NNP
cord-295559-yc8q62z8	159	13	protein	protein	NN
cord-295559-yc8q62z8	159	14	and	and	CC
cord-295559-yc8q62z8	159	15	must	must	MD
cord-295559-yc8q62z8	159	16	therefore	therefore	RB
cord-295559-yc8q62z8	159	17	enter	enter	VB
cord-295559-yc8q62z8	159	18	cells	cell	NNS
cord-295559-yc8q62z8	159	19	through	through	IN
cord-295559-yc8q62z8	159	20	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	159	21	,	,	,
cord-295559-yc8q62z8	159	22	then	then	RB
cord-295559-yc8q62z8	159	23	inhibitory	inhibitory	JJ
cord-295559-yc8q62z8	159	24	HRC	HRC	NNP
cord-295559-yc8q62z8	159	25	peptides	peptide	NNS
cord-295559-yc8q62z8	159	26	,	,	,
cord-295559-yc8q62z8	159	27	or	or	CC
cord-295559-yc8q62z8	159	28	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	159	29	antibodies	antibody	NNS
cord-295559-yc8q62z8	159	30	to	to	IN
cord-295559-yc8q62z8	159	31	HRC	HRC	NNP
cord-295559-yc8q62z8	159	32	might	may	MD
cord-295559-yc8q62z8	159	33	not	not	RB
cord-295559-yc8q62z8	159	34	penetrate	penetrate	VB
cord-295559-yc8q62z8	159	35	into	into	IN
cord-295559-yc8q62z8	159	36	the	the	DT
cord-295559-yc8q62z8	159	37	endosomes	endosome	NNS
cord-295559-yc8q62z8	159	38	to	to	TO
cord-295559-yc8q62z8	159	39	prevent	prevent	VB
cord-295559-yc8q62z8	159	40	virus	virus	NN
cord-295559-yc8q62z8	159	41	entry	entry	NN
cord-295559-yc8q62z8	159	42	.	.	.
cord-295559-yc8q62z8	160	1	However	however	RB
cord-295559-yc8q62z8	160	2	,	,	,
cord-295559-yc8q62z8	160	3	MERS	MERS	NNP
cord-295559-yc8q62z8	160	4	-	-	HYPH
cord-295559-yc8q62z8	160	5	CoV	CoV	NNP
cord-295559-yc8q62z8	160	6	virions	virion	NNS
cord-295559-yc8q62z8	160	7	in	in	IN
cord-295559-yc8q62z8	160	8	the	the	DT
cord-295559-yc8q62z8	160	9	lung	lung	NN
cord-295559-yc8q62z8	160	10	likely	likely	RB
cord-295559-yc8q62z8	160	11	have	have	VBP
cord-295559-yc8q62z8	160	12	cleaved	cleave	VBN
cord-295559-yc8q62z8	160	13	S	S	NNP
cord-295559-yc8q62z8	160	14	protein	protein	NN
cord-295559-yc8q62z8	160	15	due	due	IN
cord-295559-yc8q62z8	160	16	to	to	IN
cord-295559-yc8q62z8	160	17	lung	lung	NN
cord-295559-yc8q62z8	160	18	proteases	protease	NNS
cord-295559-yc8q62z8	160	19	,	,	,
cord-295559-yc8q62z8	160	20	so	so	IN
cord-295559-yc8q62z8	160	21	that	that	IN
cord-295559-yc8q62z8	160	22	virus	virus	NN
cord-295559-yc8q62z8	160	23	entry	entry	NN
cord-295559-yc8q62z8	160	24	at	at	IN
cord-295559-yc8q62z8	160	25	the	the	DT
cord-295559-yc8q62z8	160	26	plasma	plasma	NN
cord-295559-yc8q62z8	160	27	membrane	membrane	NN
cord-295559-yc8q62z8	160	28	might	may	MD
cord-295559-yc8q62z8	160	29	be	be	VB
cord-295559-yc8q62z8	160	30	inhibited	inhibit	VBN
cord-295559-yc8q62z8	160	31	by	by	IN
cord-295559-yc8q62z8	160	32	HRC	HRC	NNP
cord-295559-yc8q62z8	160	33	-	-	HYPH
cord-295559-yc8q62z8	160	34	targeted	target	VBN
cord-295559-yc8q62z8	160	35	peptides	peptide	NNS
cord-295559-yc8q62z8	160	36	or	or	CC
cord-295559-yc8q62z8	160	37	antibodies	antibody	NNS
cord-295559-yc8q62z8	160	38	.	.	.
cord-295559-yc8q62z8	161	1	In	in	IN
cord-295559-yc8q62z8	161	2	summary	summary	NN
cord-295559-yc8q62z8	161	3	,	,	,
cord-295559-yc8q62z8	161	4	we	-PRON-	PRP
cord-295559-yc8q62z8	161	5	demonstrated	demonstrate	VBD
cord-295559-yc8q62z8	161	6	that	that	IN
cord-295559-yc8q62z8	161	7	,	,	,
cord-295559-yc8q62z8	161	8	similar	similar	JJ
cord-295559-yc8q62z8	161	9	to	to	IN
cord-295559-yc8q62z8	161	10	SARS	SARS	NNP
cord-295559-yc8q62z8	161	11	-	-	HYPH
cord-295559-yc8q62z8	161	12	CoV	CoV	NNP
cord-295559-yc8q62z8	161	13	,	,	,
cord-295559-yc8q62z8	161	14	cleavage	cleavage	NN
cord-295559-yc8q62z8	161	15	of	of	IN
cord-295559-yc8q62z8	161	16	MERS	MERS	NNP
cord-295559-yc8q62z8	161	17	-	-	HYPH
cord-295559-yc8q62z8	161	18	CoV	CoV	NNP
cord-295559-yc8q62z8	161	19	-	-	HYPH
cord-295559-yc8q62z8	161	20	S	S	NNP
cord-295559-yc8q62z8	161	21	protein	protein	NN
cord-295559-yc8q62z8	161	22	by	by	IN
cord-295559-yc8q62z8	161	23	trypsin	trypsin	NN
cord-295559-yc8q62z8	161	24	,	,	,
cord-295559-yc8q62z8	161	25	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	161	26	or	or	CC
cord-295559-yc8q62z8	161	27	-4	-4	CD
cord-295559-yc8q62z8	161	28	or	or	CC
cord-295559-yc8q62z8	161	29	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	162	1	L	L	NNP
cord-295559-yc8q62z8	162	2	is	be	VBZ
cord-295559-yc8q62z8	162	3	required	require	VBN
cord-295559-yc8q62z8	162	4	to	to	TO
cord-295559-yc8q62z8	162	5	activate	activate	VB
cord-295559-yc8q62z8	162	6	the	the	DT
cord-295559-yc8q62z8	162	7	membrane	membrane	NN
cord-295559-yc8q62z8	162	8	fusion	fusion	NN
cord-295559-yc8q62z8	162	9	activity	activity	NN
cord-295559-yc8q62z8	162	10	of	of	IN
cord-295559-yc8q62z8	162	11	S	S	NNP
cord-295559-yc8q62z8	162	12	,	,	,
cord-295559-yc8q62z8	162	13	leading	lead	VBG
cord-295559-yc8q62z8	162	14	to	to	IN
cord-295559-yc8q62z8	162	15	virus	virus	NN
cord-295559-yc8q62z8	162	16	entry	entry	NN
cord-295559-yc8q62z8	162	17	and	and	CC
cord-295559-yc8q62z8	162	18	syncytia	syncytia	NN
cord-295559-yc8q62z8	162	19	formation	formation	NN
cord-295559-yc8q62z8	162	20	,	,	,
cord-295559-yc8q62z8	162	21	and	and	CC
cord-295559-yc8q62z8	162	22	that	that	IN
cord-295559-yc8q62z8	162	23	the	the	DT
cord-295559-yc8q62z8	162	24	location	location	NN
cord-295559-yc8q62z8	162	25	of	of	IN
cord-295559-yc8q62z8	162	26	the	the	DT
cord-295559-yc8q62z8	162	27	protease	protease	NN
cord-295559-yc8q62z8	162	28	determines	determine	VBZ
cord-295559-yc8q62z8	162	29	whether	whether	IN
cord-295559-yc8q62z8	162	30	virus	virus	NN
cord-295559-yc8q62z8	162	31	enters	enter	VBZ
cord-295559-yc8q62z8	162	32	via	via	IN
cord-295559-yc8q62z8	162	33	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	162	34	or	or	CC
cord-295559-yc8q62z8	162	35	by	by	IN
cord-295559-yc8q62z8	162	36	fusion	fusion	NN
cord-295559-yc8q62z8	162	37	at	at	IN
cord-295559-yc8q62z8	162	38	the	the	DT
cord-295559-yc8q62z8	162	39	plasma	plasma	NN
cord-295559-yc8q62z8	162	40	membrane	membrane	NN
cord-295559-yc8q62z8	162	41	.	.	.
cord-295559-yc8q62z8	163	1	MERS	MERS	NNP
cord-295559-yc8q62z8	163	2	-	-	HYPH
cord-295559-yc8q62z8	163	3	CoV	CoV	NNP
cord-295559-yc8q62z8	163	4	S	S	NNP
cord-295559-yc8q62z8	163	5	-	-	HYPH
cord-295559-yc8q62z8	163	6	mediated	mediate	VBN
cord-295559-yc8q62z8	163	7	binding	binding	NN
cord-295559-yc8q62z8	163	8	and	and	CC
cord-295559-yc8q62z8	163	9	entry	entry	NN
cord-295559-yc8q62z8	163	10	mechanisms	mechanism	NNS
cord-295559-yc8q62z8	163	11	and	and	CC
cord-295559-yc8q62z8	163	12	protease	protease	NN
cord-295559-yc8q62z8	163	13	triggering	triggering	NN
cord-295559-yc8q62z8	163	14	of	of	IN
cord-295559-yc8q62z8	163	15	conformational	conformational	JJ
cord-295559-yc8q62z8	163	16	changes	change	NNS
cord-295559-yc8q62z8	163	17	required	require	VBN
cord-295559-yc8q62z8	163	18	for	for	IN
cord-295559-yc8q62z8	163	19	MERS	MERS	NNP
cord-295559-yc8q62z8	163	20	-	-	HYPH
cord-295559-yc8q62z8	163	21	CoV	CoV	NNP
cord-295559-yc8q62z8	163	22	-	-	HYPH
cord-295559-yc8q62z8	163	23	S	S	NNP
cord-295559-yc8q62z8	163	24	virus	virus	NN
cord-295559-yc8q62z8	163	25	entry	entry	NN
cord-295559-yc8q62z8	163	26	and	and	CC
cord-295559-yc8q62z8	163	27	syncytia	syncytia	NN
cord-295559-yc8q62z8	163	28	formation	formation	NN
cord-295559-yc8q62z8	163	29	present	present	JJ
cord-295559-yc8q62z8	163	30	potential	potential	JJ
cord-295559-yc8q62z8	163	31	targets	target	NNS
cord-295559-yc8q62z8	163	32	for	for	IN
cord-295559-yc8q62z8	163	33	development	development	NN
cord-295559-yc8q62z8	163	34	of	of	IN
cord-295559-yc8q62z8	163	35	drugs	drug	NNS
cord-295559-yc8q62z8	163	36	or	or	CC
cord-295559-yc8q62z8	163	37	vaccines	vaccine	NNS
cord-295559-yc8q62z8	163	38	against	against	IN
cord-295559-yc8q62z8	163	39	this	this	DT
cord-295559-yc8q62z8	163	40	newly	newly	RB
cord-295559-yc8q62z8	163	41	emerging	emerge	VBG
cord-295559-yc8q62z8	163	42	and	and	CC
cord-295559-yc8q62z8	163	43	lethal	lethal	JJ
cord-295559-yc8q62z8	163	44	group	group	NN
cord-295559-yc8q62z8	163	45	c	c	NNP
cord-295559-yc8q62z8	163	46	human	human	NNP
cord-295559-yc8q62z8	163	47	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	163	48	.	.	.
cord-295559-yc8q62z8	164	1	Codon	Codon	NNP
cord-295559-yc8q62z8	164	2	-	-	HYPH
cord-295559-yc8q62z8	164	3	optimized	optimize	VBN
cord-295559-yc8q62z8	164	4	cDNA	cdna	NN
cord-295559-yc8q62z8	164	5	encoding	encode	VBG
cord-295559-yc8q62z8	164	6	the	the	DT
cord-295559-yc8q62z8	164	7	spike	spike	NN
cord-295559-yc8q62z8	164	8	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	164	9	of	of	IN
cord-295559-yc8q62z8	164	10	MERS	MERS	NNP
cord-295559-yc8q62z8	164	11	-	-	HYPH
cord-295559-yc8q62z8	164	12	CoV	CoV	NNP
cord-295559-yc8q62z8	164	13	[	[	-LRB-
cord-295559-yc8q62z8	164	14	15	15	CD
cord-295559-yc8q62z8	164	15	]	]	-RRB-
cord-295559-yc8q62z8	164	16	was	be	VBD
cord-295559-yc8q62z8	164	17	synthesized	synthesize	VBN
cord-295559-yc8q62z8	164	18	with	with	IN
cord-295559-yc8q62z8	164	19	the	the	DT
cord-295559-yc8q62z8	164	20	c	c	NN
cord-295559-yc8q62z8	164	21	-	-	HYPH
cord-295559-yc8q62z8	164	22	terminal	terminal	NN
cord-295559-yc8q62z8	164	23	16	16	CD
cord-295559-yc8q62z8	164	24	amino	amino	JJ
cord-295559-yc8q62z8	164	25	acids	acid	NNS
cord-295559-yc8q62z8	164	26	replaced	replace	VBN
cord-295559-yc8q62z8	164	27	with	with	IN
cord-295559-yc8q62z8	164	28	a	a	DT
cord-295559-yc8q62z8	164	29	GGGGS	GGGGS	NNP
cord-295559-yc8q62z8	164	30	linker	linker	NN
cord-295559-yc8q62z8	164	31	and	and	CC
cord-295559-yc8q62z8	164	32	a	a	DT
cord-295559-yc8q62z8	164	33	FLAG	flag	NN
cord-295559-yc8q62z8	164	34	tag	tag	NN
cord-295559-yc8q62z8	164	35	(	(	-LRB-
cord-295559-yc8q62z8	164	36	GenScript	GenScript	NNP
cord-295559-yc8q62z8	164	37	,	,	,
cord-295559-yc8q62z8	164	38	Piscataway	Piscataway	NNP
cord-295559-yc8q62z8	164	39	,	,	,
cord-295559-yc8q62z8	164	40	NJ	NJ	NNP
cord-295559-yc8q62z8	164	41	)	)	-RRB-
cord-295559-yc8q62z8	164	42	,	,	,
cord-295559-yc8q62z8	164	43	and	and	CC
cord-295559-yc8q62z8	164	44	for	for	IN
cord-295559-yc8q62z8	164	45	eukaryotic	eukaryotic	JJ
cord-295559-yc8q62z8	164	46	expression	expression	NN
cord-295559-yc8q62z8	164	47	was	be	VBD
cord-295559-yc8q62z8	164	48	cloned	clone	VBN
cord-295559-yc8q62z8	164	49	into	into	IN
cord-295559-yc8q62z8	164	50	pcDNA3.1(+	pcDNA3.1(+	NNP
cord-295559-yc8q62z8	164	51	)	)	-RRB-
cord-295559-yc8q62z8	165	1	(	(	-LRB-
cord-295559-yc8q62z8	165	2	Invitrogen	Invitrogen	NNP
cord-295559-yc8q62z8	165	3	)	)	-RRB-
cord-295559-yc8q62z8	165	4	between	between	IN
cord-295559-yc8q62z8	165	5	the	the	DT
cord-295559-yc8q62z8	165	6	BamHI	BamHI	NNP
cord-295559-yc8q62z8	165	7	and	and	CC
cord-295559-yc8q62z8	165	8	NotI	NotI	NNP
cord-295559-yc8q62z8	165	9	sites	site	NNS
cord-295559-yc8q62z8	165	10	.	.	.
cord-295559-yc8q62z8	166	1	To	to	TO
cord-295559-yc8q62z8	166	2	make	make	VB
cord-295559-yc8q62z8	166	3	constructs	construct	NNS
cord-295559-yc8q62z8	166	4	for	for	IN
cord-295559-yc8q62z8	166	5	expression	expression	NN
cord-295559-yc8q62z8	166	6	of	of	IN
cord-295559-yc8q62z8	166	7	truncated	truncated	JJ
cord-295559-yc8q62z8	166	8	soluble	soluble	JJ
cord-295559-yc8q62z8	166	9	MERS	MERS	NNP
cord-295559-yc8q62z8	166	10	S	S	NNP
cord-295559-yc8q62z8	166	11	aa1	aa1	NNP
cord-295559-yc8q62z8	166	12	-	-	HYPH
cord-295559-yc8q62z8	166	13	351	351	CD
cord-295559-yc8q62z8	166	14	,	,	,
cord-295559-yc8q62z8	166	15	S	S	NNP
cord-295559-yc8q62z8	166	16	aa1	aa1	NNP
cord-295559-yc8q62z8	166	17	-	-	HYPH
cord-295559-yc8q62z8	166	18	384	384	CD
cord-295559-yc8q62z8	166	19	,	,	,
cord-295559-yc8q62z8	166	20	and	and	CC
cord-295559-yc8q62z8	166	21	S	S	NNP
cord-295559-yc8q62z8	166	22	aa1	aa1	NNP
cord-295559-yc8q62z8	166	23	-	-	HYPH
cord-295559-yc8q62z8	166	24	748	748	CD
cord-295559-yc8q62z8	166	25	proteins	protein	NNS
cord-295559-yc8q62z8	166	26	,	,	,
cord-295559-yc8q62z8	166	27	PCR	PCR	NNP
cord-295559-yc8q62z8	166	28	reactions	reaction	NNS
cord-295559-yc8q62z8	166	29	were	be	VBD
cord-295559-yc8q62z8	166	30	performed	perform	VBN
cord-295559-yc8q62z8	166	31	using	use	VBG
cord-295559-yc8q62z8	166	32	the	the	DT
cord-295559-yc8q62z8	166	33	same	same	JJ
cord-295559-yc8q62z8	166	34	forward	forward	JJ
cord-295559-yc8q62z8	166	35	primer	primer	NN
cord-295559-yc8q62z8	166	36	AATGAAAAGCTTCACCATGATTCACTCCGTGTTCCTC	AATGAAAAGCTTCACCATGATTCACTCCGTGTTCCTC	NNP
cord-295559-yc8q62z8	166	37	pairing	pair	VBG
cord-295559-yc8q62z8	166	38	with	with	IN
cord-295559-yc8q62z8	166	39	the	the	DT
cord-295559-yc8q62z8	166	40	following	following	JJ
cord-295559-yc8q62z8	166	41	reverse	reverse	NN
cord-295559-yc8q62z8	166	42	primers	primer	NNS
cord-295559-yc8q62z8	166	43	,	,	,
cord-295559-yc8q62z8	166	44	for	for	IN
cord-295559-yc8q62z8	166	45	S	S	NNP
cord-295559-yc8q62z8	166	46	aa1	aa1	NNP
cord-295559-yc8q62z8	166	47	-	-	HYPH
cord-295559-yc8q62z8	166	48	351	351	CD
cord-295559-yc8q62z8	166	49	:	:	:
cord-295559-yc8q62z8	166	50	TAGTTTTCTAGAACTTCCGCCTCCACCATAA	TAGTTTTCTAGAACTTCCGCCTCCACCATAA	NNP
cord-295559-yc8q62z8	166	51	CTACAGTGGAGCTGGCT	CTACAGTGGAGCTGGCT	NNP
cord-295559-yc8q62z8	166	52	;	;	:
cord-295559-yc8q62z8	166	53	for	for	IN
cord-295559-yc8q62z8	166	54	S	S	NNP
cord-295559-yc8q62z8	166	55	aa1	aa1	NNP
cord-295559-yc8q62z8	166	56	-	-	HYPH
cord-295559-yc8q62z8	166	57	384	384	CD
cord-295559-yc8q62z8	166	58	:	:	:
cord-295559-yc8q62z8	166	59	TAGTTTTCTAGAACTTCCGCCTCCAC	TAGTTTTCTAGAACTTCCGCCTCCAC	NNP
cord-295559-yc8q62z8	166	60	CGTCGCACTCCACGCCTTCTGCC	CGTCGCACTCCACGCCTTCTGCC	NNP
cord-295559-yc8q62z8	166	61	;	;	:
cord-295559-yc8q62z8	166	62	or	or	CC
cord-295559-yc8q62z8	166	63	for	for	IN
cord-295559-yc8q62z8	166	64	S	S	NNP
cord-295559-yc8q62z8	166	65	aa1	aa1	NNP
cord-295559-yc8q62z8	166	66	-	-	HYPH
cord-295559-yc8q62z8	166	67	748	748	CD
cord-295559-yc8q62z8	166	68	TAGTTTTCTAGAACTTC	TAGTTTTCTAGAACTTC	NNP
cord-295559-yc8q62z8	166	69	CGCCTCCACCTGGGGTCAGTGTGCTGGGGGT	CGCCTCCACCTGGGGTCAGTGTGCTGGGGGT	NNP
cord-295559-yc8q62z8	166	70	,	,	,
cord-295559-yc8q62z8	166	71	and	and	CC
cord-295559-yc8q62z8	166	72	cloned	clone	VBN
cord-295559-yc8q62z8	166	73	into	into	IN
cord-295559-yc8q62z8	166	74	p3xFLAG	p3xFLAG	NNP
cord-295559-yc8q62z8	166	75	-	-	HYPH
cord-295559-yc8q62z8	166	76	CMV	CMV	NNP
cord-295559-yc8q62z8	166	77	14	14	CD
cord-295559-yc8q62z8	167	1	(	(	-LRB-
cord-295559-yc8q62z8	167	2	Sigma	Sigma	NNP
cord-295559-yc8q62z8	167	3	,	,	,
cord-295559-yc8q62z8	167	4	St	St	NNP
cord-295559-yc8q62z8	167	5	Louis	Louis	NNP
cord-295559-yc8q62z8	167	6	,	,	,
cord-295559-yc8q62z8	167	7	MO	MO	NNP
cord-295559-yc8q62z8	167	8	)	)	-RRB-
cord-295559-yc8q62z8	167	9	between	between	IN
cord-295559-yc8q62z8	167	10	HindIII	HindIII	NNS
cord-295559-yc8q62z8	167	11	and	and	CC
cord-295559-yc8q62z8	167	12	XbaI	XbaI	NNP
cord-295559-yc8q62z8	167	13	sites	site	NNS
cord-295559-yc8q62z8	167	14	for	for	IN
cord-295559-yc8q62z8	167	15	expression	expression	NN
cord-295559-yc8q62z8	167	16	.	.	.
cord-295559-yc8q62z8	168	1	The	the	DT
cord-295559-yc8q62z8	168	2	VSV	VSV	NNP
cord-295559-yc8q62z8	168	3	-	-	HYPH
cord-295559-yc8q62z8	168	4	g	g	NN
cord-295559-yc8q62z8	168	5	plasmid	plasmid	NN
cord-295559-yc8q62z8	168	6	and	and	CC
cord-295559-yc8q62z8	168	7	lentiviral	lentiviral	JJ
cord-295559-yc8q62z8	168	8	packaging	packaging	NN
cord-295559-yc8q62z8	168	9	plasmid	plasmid	NN
cord-295559-yc8q62z8	168	10	,	,	,
cord-295559-yc8q62z8	168	11	psPAX2	psPAX2	NNP
cord-295559-yc8q62z8	168	12	,	,	,
cord-295559-yc8q62z8	168	13	were	be	VBD
cord-295559-yc8q62z8	168	14	obtained	obtain	VBN
cord-295559-yc8q62z8	168	15	from	from	IN
cord-295559-yc8q62z8	168	16	Addgene	Addgene	NNP
cord-295559-yc8q62z8	168	17	(	(	-LRB-
cord-295559-yc8q62z8	168	18	Cambridge	Cambridge	NNP
cord-295559-yc8q62z8	168	19	,	,	,
cord-295559-yc8q62z8	168	20	MA	MA	NNP
cord-295559-yc8q62z8	168	21	)	)	-RRB-
cord-295559-yc8q62z8	168	22	.	.	.
cord-295559-yc8q62z8	169	1	The	the	DT
cord-295559-yc8q62z8	169	2	lentiviral	lentiviral	JJ
cord-295559-yc8q62z8	169	3	reporter	reporter	NN
cord-295559-yc8q62z8	169	4	plasmid	plasmid	NN
cord-295559-yc8q62z8	169	5	,	,	,
cord-295559-yc8q62z8	169	6	pLenti	pLenti	NNP
cord-295559-yc8q62z8	169	7	-	-	HYPH
cord-295559-yc8q62z8	169	8	GFP	GFP	NNP
cord-295559-yc8q62z8	169	9	-	-	HYPH
cord-295559-yc8q62z8	169	10	Luc	Luc	NNP
cord-295559-yc8q62z8	169	11	,	,	,
cord-295559-yc8q62z8	169	12	which	which	WDT
cord-295559-yc8q62z8	169	13	expresses	express	VBZ
cord-295559-yc8q62z8	169	14	green	green	JJ
cord-295559-yc8q62z8	169	15	fluorescent	fluorescent	NN
cord-295559-yc8q62z8	169	16	protein	protein	NN
cord-295559-yc8q62z8	169	17	(	(	-LRB-
cord-295559-yc8q62z8	169	18	GFP	GFP	NNP
cord-295559-yc8q62z8	169	19	)	)	-RRB-
cord-295559-yc8q62z8	169	20	and	and	CC
cord-295559-yc8q62z8	169	21	luciferase	luciferase	NN
cord-295559-yc8q62z8	169	22	,	,	,
cord-295559-yc8q62z8	169	23	was	be	VBD
cord-295559-yc8q62z8	169	24	kindly	kindly	RB
cord-295559-yc8q62z8	169	25	provided	provide	VBN
cord-295559-yc8q62z8	169	26	by	by	IN
cord-295559-yc8q62z8	169	27	Fang	Fang	NNP
cord-295559-yc8q62z8	169	28	Li	Li	NNP
cord-295559-yc8q62z8	169	29	,	,	,
cord-295559-yc8q62z8	169	30	Duke	Duke	NNP
cord-295559-yc8q62z8	169	31	University	University	NNP
cord-295559-yc8q62z8	169	32	[	[	-LRB-
cord-295559-yc8q62z8	169	33	68	68	CD
cord-295559-yc8q62z8	169	34	]	]	-RRB-
cord-295559-yc8q62z8	169	35	 	 	_SP
cord-295559-yc8q62z8	169	36	The	the	DT
cord-295559-yc8q62z8	169	37	Vero	Vero	NNP
cord-295559-yc8q62z8	169	38	E6	E6	NNP
cord-295559-yc8q62z8	169	39	line	line	NN
cord-295559-yc8q62z8	169	40	of	of	IN
cord-295559-yc8q62z8	169	41	African	african	JJ
cord-295559-yc8q62z8	169	42	green	green	JJ
cord-295559-yc8q62z8	169	43	monkey	monkey	NN
cord-295559-yc8q62z8	169	44	kidney	kidney	NN
cord-295559-yc8q62z8	169	45	cells	cell	NNS
cord-295559-yc8q62z8	169	46	,	,	,
cord-295559-yc8q62z8	169	47	the	the	DT
cord-295559-yc8q62z8	169	48	293	293	CD
cord-295559-yc8q62z8	169	49	T	T	NNP
cord-295559-yc8q62z8	169	50	line	line	NN
cord-295559-yc8q62z8	169	51	of	of	IN
cord-295559-yc8q62z8	169	52	human	human	JJ
cord-295559-yc8q62z8	169	53	embryonic	embryonic	JJ
cord-295559-yc8q62z8	169	54	kidney	kidney	NN
cord-295559-yc8q62z8	169	55	cells	cell	NNS
cord-295559-yc8q62z8	169	56	transformed	transform	VBN
cord-295559-yc8q62z8	169	57	with	with	IN
cord-295559-yc8q62z8	169	58	SV40	SV40	NNP
cord-295559-yc8q62z8	169	59	large	large	JJ
cord-295559-yc8q62z8	169	60	T	t	NN
cord-295559-yc8q62z8	169	61	antigen	antigen	NN
cord-295559-yc8q62z8	169	62	,	,	,
cord-295559-yc8q62z8	169	63	the	the	DT
cord-295559-yc8q62z8	169	64	Calu	Calu	NNP
cord-295559-yc8q62z8	169	65	3	3	CD
cord-295559-yc8q62z8	169	66	line	line	NN
cord-295559-yc8q62z8	169	67	of	of	IN
cord-295559-yc8q62z8	169	68	human	human	JJ
cord-295559-yc8q62z8	169	69	airway	airway	NN
cord-295559-yc8q62z8	169	70	epithelial	epithelial	JJ
cord-295559-yc8q62z8	169	71	cells	cell	NNS
cord-295559-yc8q62z8	169	72	,	,	,
cord-295559-yc8q62z8	169	73	the	the	DT
cord-295559-yc8q62z8	169	74	A549	a549	JJ
cord-295559-yc8q62z8	169	75	line	line	NN
cord-295559-yc8q62z8	169	76	of	of	IN
cord-295559-yc8q62z8	169	77	human	human	JJ
cord-295559-yc8q62z8	169	78	alveolar	alveolar	NN
cord-295559-yc8q62z8	169	79	epithelial	epithelial	JJ
cord-295559-yc8q62z8	169	80	cells	cell	NNS
cord-295559-yc8q62z8	169	81	,	,	,
cord-295559-yc8q62z8	169	82	and	and	CC
cord-295559-yc8q62z8	169	83	the	the	DT
cord-295559-yc8q62z8	169	84	TB1Lu	TB1Lu	NNP
cord-295559-yc8q62z8	169	85	lung	lung	NN
cord-295559-yc8q62z8	169	86	cell	cell	NN
cord-295559-yc8q62z8	169	87	line	line	NN
cord-295559-yc8q62z8	169	88	from	from	IN
cord-295559-yc8q62z8	169	89	T.	t.	NN
cord-295559-yc8q62z8	169	90	brasiliensis	brasiliensis	NN
cord-295559-yc8q62z8	169	91	bats	bat	NNS
cord-295559-yc8q62z8	169	92	were	be	VBD
cord-295559-yc8q62z8	169	93	obtained	obtain	VBN
cord-295559-yc8q62z8	169	94	from	from	IN
cord-295559-yc8q62z8	169	95	ATCC	ATCC	NNP
cord-295559-yc8q62z8	169	96	(	(	-LRB-
cord-295559-yc8q62z8	169	97	Manassas	Manassas	NNP
cord-295559-yc8q62z8	169	98	,	,	,
cord-295559-yc8q62z8	169	99	VA	VA	NNP
cord-295559-yc8q62z8	169	100	)	)	-RRB-
cord-295559-yc8q62z8	169	101	.	.	.
cord-295559-yc8q62z8	170	1	Hela	Hela	NNP
cord-295559-yc8q62z8	170	2	cells	cell	NNS
cord-295559-yc8q62z8	170	3	stably	stably	RB
cord-295559-yc8q62z8	170	4	expressing	express	VBG
cord-295559-yc8q62z8	170	5	recombinant	recombinant	JJ
cord-295559-yc8q62z8	170	6	human	human	JJ
cord-295559-yc8q62z8	170	7	CEACAM	CEACAM	NNP
cord-295559-yc8q62z8	170	8	proteins	protein	NNS
cord-295559-yc8q62z8	170	9	and	and	CC
cord-295559-yc8q62z8	170	10	the	the	DT
cord-295559-yc8q62z8	170	11	control	control	NN
cord-295559-yc8q62z8	170	12	Hela	Hela	NNP
cord-295559-yc8q62z8	170	13	cell	cell	NN
cord-295559-yc8q62z8	170	14	line	line	NN
cord-295559-yc8q62z8	170	15	containing	contain	VBG
cord-295559-yc8q62z8	170	16	the	the	DT
cord-295559-yc8q62z8	170	17	empty	empty	JJ
cord-295559-yc8q62z8	170	18	vector	vector	NN
cord-295559-yc8q62z8	170	19	were	be	VBD
cord-295559-yc8q62z8	170	20	kindly	kindly	RB
cord-295559-yc8q62z8	170	21	provided	provide	VBN
cord-295559-yc8q62z8	170	22	by	by	IN
cord-295559-yc8q62z8	170	23	Scott	Scott	NNP
cord-295559-yc8q62z8	170	24	Gray	Gray	NNP
cord-295559-yc8q62z8	170	25	-	-	HYPH
cord-295559-yc8q62z8	170	26	Owen	Owen	NNP
cord-295559-yc8q62z8	170	27	,	,	,
cord-295559-yc8q62z8	170	28	University	University	NNP
cord-295559-yc8q62z8	170	29	of	of	IN
cord-295559-yc8q62z8	170	30	Toronto	Toronto	NNP
cord-295559-yc8q62z8	170	31	[	[	-LRB-
cord-295559-yc8q62z8	170	32	69	69	CD
cord-295559-yc8q62z8	170	33	]	]	-RRB-
cord-295559-yc8q62z8	170	34	.	.	.
cord-295559-yc8q62z8	171	1	The	the	DT
cord-295559-yc8q62z8	171	2	bat	bat	NN
cord-295559-yc8q62z8	171	3	EFF	eff	NN
cord-295559-yc8q62z8	171	4	cells	cell	NNS
cord-295559-yc8q62z8	171	5	were	be	VBD
cord-295559-yc8q62z8	171	6	prepared	prepare	VBN
cord-295559-yc8q62z8	171	7	by	by	IN
cord-295559-yc8q62z8	171	8	macerating	macerate	VBG
cord-295559-yc8q62z8	171	9	mid	mid	JJ
cord-295559-yc8q62z8	171	10	-	-	JJ
cord-295559-yc8q62z8	171	11	gestation	gestation	JJ
cord-295559-yc8q62z8	171	12	fetuses	fetus	NNS
cord-295559-yc8q62z8	171	13	of	of	IN
cord-295559-yc8q62z8	171	14	Eptesicus	Eptesicus	NNP
cord-295559-yc8q62z8	171	15	fuscus	fuscus	NN
cord-295559-yc8q62z8	171	16	bats	bat	NNS
cord-295559-yc8q62z8	171	17	,	,	,
cord-295559-yc8q62z8	171	18	briefly	briefly	RB
cord-295559-yc8q62z8	171	19	trypsinizing	trypsinize	VBG
cord-295559-yc8q62z8	171	20	the	the	DT
cord-295559-yc8q62z8	171	21	cells	cell	NNS
cord-295559-yc8q62z8	171	22	,	,	,
cord-295559-yc8q62z8	171	23	and	and	CC
cord-295559-yc8q62z8	171	24	plating	plate	VBG
cord-295559-yc8q62z8	171	25	them	-PRON-	PRP
cord-295559-yc8q62z8	171	26	for	for	IN
cord-295559-yc8q62z8	171	27	expansion	expansion	NN
cord-295559-yc8q62z8	171	28	.	.	.
cord-295559-yc8q62z8	172	1	Cells	cell	NNS
cord-295559-yc8q62z8	172	2	were	be	VBD
cord-295559-yc8q62z8	172	3	passaged	passage	VBN
cord-295559-yc8q62z8	172	4	twice	twice	RB
cord-295559-yc8q62z8	172	5	,	,	,
cord-295559-yc8q62z8	172	6	frozen	frozen	JJ
cord-295559-yc8q62z8	172	7	,	,	,
cord-295559-yc8q62z8	172	8	and	and	CC
cord-295559-yc8q62z8	172	9	kindly	kindly	RB
cord-295559-yc8q62z8	172	10	provided	provide	VBN
cord-295559-yc8q62z8	172	11	by	by	IN
cord-295559-yc8q62z8	172	12	Richard	Richard	NNP
cord-295559-yc8q62z8	172	13	Bowen	Bowen	NNP
cord-295559-yc8q62z8	172	14	,	,	,
cord-295559-yc8q62z8	172	15	Colorado	Colorado	NNP
cord-295559-yc8q62z8	172	16	State	State	NNP
cord-295559-yc8q62z8	172	17	University	University	NNP
cord-295559-yc8q62z8	172	18	.	.	.
cord-295559-yc8q62z8	173	1	Isolation	isolation	NN
cord-295559-yc8q62z8	173	2	of	of	IN
cord-295559-yc8q62z8	173	3	the	the	DT
cord-295559-yc8q62z8	173	4	EFF	EFF	NNP
cord-295559-yc8q62z8	173	5	cells	cell	NNS
cord-295559-yc8q62z8	173	6	was	be	VBD
cord-295559-yc8q62z8	173	7	conducted	conduct	VBN
cord-295559-yc8q62z8	173	8	under	under	IN
cord-295559-yc8q62z8	173	9	approval	approval	NN
cord-295559-yc8q62z8	173	10	03	03	CD
cord-295559-yc8q62z8	173	11	-	-	SYM
cord-295559-yc8q62z8	173	12	096A	096A	NNP
cord-295559-yc8q62z8	173	13	from	from	IN
cord-295559-yc8q62z8	173	14	the	the	DT
cord-295559-yc8q62z8	173	15	Colorado	Colorado	NNP
cord-295559-yc8q62z8	173	16	State	State	NNP
cord-295559-yc8q62z8	173	17	University	University	NNP
cord-295559-yc8q62z8	173	18	IACUC	IACUC	NNP
cord-295559-yc8q62z8	173	19	.	.	.
cord-295559-yc8q62z8	174	1	Murine	Murine	NNP
cord-295559-yc8q62z8	174	2	NIH3T3	NIH3T3	NNP
cord-295559-yc8q62z8	174	3	cells	cell	NNS
cord-295559-yc8q62z8	174	4	stably	stably	RB
cord-295559-yc8q62z8	174	5	expressing	express	VBG
cord-295559-yc8q62z8	174	6	recombinant	recombinant	JJ
cord-295559-yc8q62z8	174	7	human	human	JJ
cord-295559-yc8q62z8	174	8	aminopeptidase	aminopeptidase	NN
cord-295559-yc8q62z8	174	9	N	N	NNP
cord-295559-yc8q62z8	174	10	(	(	-LRB-
cord-295559-yc8q62z8	174	11	hAPN	hapn	NN
cord-295559-yc8q62z8	174	12	)	)	-RRB-
cord-295559-yc8q62z8	174	13	or	or	CC
cord-295559-yc8q62z8	174	14	control	control	NN
cord-295559-yc8q62z8	174	15	cells	cell	NNS
cord-295559-yc8q62z8	174	16	with	with	IN
cord-295559-yc8q62z8	174	17	empty	empty	JJ
cord-295559-yc8q62z8	174	18	vector	vector	NN
cord-295559-yc8q62z8	174	19	were	be	VBD
cord-295559-yc8q62z8	174	20	previously	previously	RB
cord-295559-yc8q62z8	174	21	described	describe	VBN
cord-295559-yc8q62z8	174	22	[	[	-LRB-
cord-295559-yc8q62z8	174	23	70	70	CD
cord-295559-yc8q62z8	174	24	]	]	-RRB-
cord-295559-yc8q62z8	174	25	.	.	.
cord-295559-yc8q62z8	175	1	These	these	DT
cord-295559-yc8q62z8	175	2	cell	cell	NN
cord-295559-yc8q62z8	175	3	lines	line	NNS
cord-295559-yc8q62z8	175	4	were	be	VBD
cord-295559-yc8q62z8	175	5	maintained	maintain	VBN
cord-295559-yc8q62z8	175	6	in	in	IN
cord-295559-yc8q62z8	175	7	Dulbecco	Dulbecco	NNP
cord-295559-yc8q62z8	175	8	's	's	POS
cord-295559-yc8q62z8	175	9	MEM	mem	NN
cord-295559-yc8q62z8	175	10	with	with	IN
cord-295559-yc8q62z8	175	11	10	10	CD
cord-295559-yc8q62z8	175	12	%	%	NN
cord-295559-yc8q62z8	175	13	fetal	fetal	JJ
cord-295559-yc8q62z8	175	14	bovine	bovine	JJ
cord-295559-yc8q62z8	175	15	serum	serum	NN
cord-295559-yc8q62z8	175	16	(	(	-LRB-
cord-295559-yc8q62z8	175	17	FBS	FBS	NNP
cord-295559-yc8q62z8	175	18	)	)	-RRB-
cord-295559-yc8q62z8	175	19	and	and	CC
cord-295559-yc8q62z8	175	20	2	2	CD
cord-295559-yc8q62z8	175	21	%	%	NN
cord-295559-yc8q62z8	175	22	penicillin	penicillin	NN
cord-295559-yc8q62z8	175	23	,	,	,
cord-295559-yc8q62z8	175	24	streptomycin	streptomycin	NNS
cord-295559-yc8q62z8	175	25	,	,	,
cord-295559-yc8q62z8	175	26	and	and	CC
cord-295559-yc8q62z8	175	27	Fugizone	Fugizone	NNP
cord-295559-yc8q62z8	175	28	(	(	-LRB-
cord-295559-yc8q62z8	175	29	PSF	psf	NN
cord-295559-yc8q62z8	175	30	)	)	-RRB-
cord-295559-yc8q62z8	176	1	(	(	-LRB-
cord-295559-yc8q62z8	176	2	Life	Life	NNP
cord-295559-yc8q62z8	176	3	Technologies	Technologies	NNPS
cord-295559-yc8q62z8	176	4	Inc	Inc	NNP
cord-295559-yc8q62z8	176	5	,	,	,
cord-295559-yc8q62z8	176	6	Grand	Grand	NNP
cord-295559-yc8q62z8	176	7	Island	Island	NNP
cord-295559-yc8q62z8	176	8	,	,	,
cord-295559-yc8q62z8	176	9	NY	NY	NNP
cord-295559-yc8q62z8	176	10	)	)	-RRB-
cord-295559-yc8q62z8	176	11	.	.	.
cord-295559-yc8q62z8	177	1	The	the	DT
cord-295559-yc8q62z8	177	2	LLC	LLC	NNP
cord-295559-yc8q62z8	177	3	-	-	HYPH
cord-295559-yc8q62z8	177	4	MK2	MK2	NNP
cord-295559-yc8q62z8	177	5	line	line	NN
cord-295559-yc8q62z8	177	6	of	of	IN
cord-295559-yc8q62z8	177	7	rhesus	rhesus	NNP
cord-295559-yc8q62z8	177	8	monkey	monkey	NN
cord-295559-yc8q62z8	177	9	kidney	kidney	NN
cord-295559-yc8q62z8	177	10	cells	cell	NNS
cord-295559-yc8q62z8	177	11	from	from	IN
cord-295559-yc8q62z8	177	12	ATCC	ATCC	NNP
cord-295559-yc8q62z8	177	13	CCL-7	CCL-7	NNP
cord-295559-yc8q62z8	177	14	was	be	VBD
cord-295559-yc8q62z8	177	15	maintained	maintain	VBN
cord-295559-yc8q62z8	177	16	in	in	IN
cord-295559-yc8q62z8	177	17	Opti	Opti	NNP
cord-295559-yc8q62z8	177	18	-	-	HYPH
cord-295559-yc8q62z8	177	19	MEM1	MEM1	NNP
cord-295559-yc8q62z8	178	1	(	(	-LRB-
cord-295559-yc8q62z8	178	2	Life	Life	NNP
cord-295559-yc8q62z8	178	3	Technologies	Technologies	NNPS
cord-295559-yc8q62z8	178	4	Inc	Inc	NNP
cord-295559-yc8q62z8	178	5	,	,	,
cord-295559-yc8q62z8	178	6	Grand	Grand	NNP
cord-295559-yc8q62z8	178	7	Island	Island	NNP
cord-295559-yc8q62z8	178	8	,	,	,
cord-295559-yc8q62z8	178	9	NY	NY	NNP
cord-295559-yc8q62z8	178	10	)	)	-RRB-
cord-295559-yc8q62z8	178	11	with	with	IN
cord-295559-yc8q62z8	178	12	10	10	CD
cord-295559-yc8q62z8	178	13	%	%	NN
cord-295559-yc8q62z8	178	14	FBS	FBS	NNP
cord-295559-yc8q62z8	178	15	and	and	CC
cord-295559-yc8q62z8	178	16	2	2	CD
cord-295559-yc8q62z8	178	17	%	%	NN
cord-295559-yc8q62z8	178	18	PSF	psf	NN
cord-295559-yc8q62z8	178	19	.	.	.
cord-295559-yc8q62z8	179	1	Pseudotyped	Pseudotyped	NNP
cord-295559-yc8q62z8	179	2	lentiviruses	lentiviruse	NNS
cord-295559-yc8q62z8	179	3	were	be	VBD
cord-295559-yc8q62z8	179	4	produced	produce	VBN
cord-295559-yc8q62z8	179	5	as	as	IN
cord-295559-yc8q62z8	179	6	described	describe	VBN
cord-295559-yc8q62z8	179	7	previously	previously	RB
cord-295559-yc8q62z8	179	8	[	[	-LRB-
cord-295559-yc8q62z8	179	9	71	71	CD
cord-295559-yc8q62z8	179	10	]	]	-RRB-
cord-295559-yc8q62z8	179	11	with	with	IN
cord-295559-yc8q62z8	179	12	minor	minor	JJ
cord-295559-yc8q62z8	179	13	modifications	modification	NNS
cord-295559-yc8q62z8	179	14	.	.	.
cord-295559-yc8q62z8	180	1	Briefly	briefly	RB
cord-295559-yc8q62z8	180	2	,	,	,
cord-295559-yc8q62z8	180	3	plasmids	plasmid	NNS
cord-295559-yc8q62z8	180	4	that	that	WDT
cord-295559-yc8q62z8	180	5	encode	encode	VBP
cord-295559-yc8q62z8	180	6	viral	viral	JJ
cord-295559-yc8q62z8	180	7	spike	spike	NN
cord-295559-yc8q62z8	180	8	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	180	9	MERS	MERS	NNP
cord-295559-yc8q62z8	180	10	-	-	HYPH
cord-295559-yc8q62z8	180	11	CoV	CoV	NNP
cord-295559-yc8q62z8	180	12	S∆16	S∆16	NNP
cord-295559-yc8q62z8	180	13	,	,	,
cord-295559-yc8q62z8	180	14	SARS	SARS	NNP
cord-295559-yc8q62z8	180	15	S∆19	S∆19	NNP
cord-295559-yc8q62z8	180	16	,	,	,
cord-295559-yc8q62z8	180	17	or	or	CC
cord-295559-yc8q62z8	180	18	VSV	VSV	NNP
cord-295559-yc8q62z8	180	19	-	-	HYPH
cord-295559-yc8q62z8	180	20	g	g	NNP
cord-295559-yc8q62z8	180	21	were	be	VBD
cord-295559-yc8q62z8	180	22	co	co	VBN
cord-295559-yc8q62z8	180	23	-	-	VBN
cord-295559-yc8q62z8	180	24	transfected	transfecte	VBN
cord-295559-yc8q62z8	180	25	into	into	IN
cord-295559-yc8q62z8	180	26	293	293	CD
cord-295559-yc8q62z8	180	27	T	t	NN
cord-295559-yc8q62z8	180	28	cells	cell	NNS
cord-295559-yc8q62z8	180	29	with	with	IN
cord-295559-yc8q62z8	180	30	psPAX2	psPAX2	NNP
cord-295559-yc8q62z8	180	31	and	and	CC
cord-295559-yc8q62z8	180	32	pLenti	pLenti	NNP
cord-295559-yc8q62z8	180	33	-	-	HYPH
cord-295559-yc8q62z8	180	34	GFP	GFP	NNP
cord-295559-yc8q62z8	180	35	-	-	HYPH
cord-295559-yc8q62z8	180	36	Luc	Luc	NNP
cord-295559-yc8q62z8	180	37	using	use	VBG
cord-295559-yc8q62z8	180	38	polyetherimide	polyetherimide	NNP
cord-295559-yc8q62z8	180	39	(	(	-LRB-
cord-295559-yc8q62z8	180	40	PEI	PEI	NNP
cord-295559-yc8q62z8	180	41	)	)	-RRB-
cord-295559-yc8q62z8	181	1	(	(	-LRB-
cord-295559-yc8q62z8	181	2	Polyscience	Polyscience	NNP
cord-295559-yc8q62z8	181	3	Inc	Inc	NNP
cord-295559-yc8q62z8	181	4	,	,	,
cord-295559-yc8q62z8	181	5	Warrington	Warrington	NNP
cord-295559-yc8q62z8	181	6	,	,	,
cord-295559-yc8q62z8	181	7	PA	PA	NNP
cord-295559-yc8q62z8	181	8	)	)	-RRB-
cord-295559-yc8q62z8	181	9	.	.	.
cord-295559-yc8q62z8	182	1	Forty	forty	CD
cord-295559-yc8q62z8	182	2	to	to	TO
cord-295559-yc8q62z8	182	3	60	60	CD
cord-295559-yc8q62z8	182	4	hr	hr	NN
cord-295559-yc8q62z8	182	5	later	later	RB
cord-295559-yc8q62z8	182	6	the	the	DT
cord-295559-yc8q62z8	182	7	supernatant	supernatant	JJ
cord-295559-yc8q62z8	182	8	media	media	NN
cord-295559-yc8q62z8	182	9	containing	contain	VBG
cord-295559-yc8q62z8	182	10	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	182	11	were	be	VBD
cord-295559-yc8q62z8	182	12	centrifuged	centrifuge	VBN
cord-295559-yc8q62z8	182	13	at	at	IN
cord-295559-yc8q62z8	182	14	800	800	CD
cord-295559-yc8q62z8	182	15	g	g	NN
cord-295559-yc8q62z8	182	16	for	for	IN
cord-295559-yc8q62z8	182	17	5min	5min	NN
cord-295559-yc8q62z8	182	18	to	to	TO
cord-295559-yc8q62z8	182	19	remove	remove	VB
cord-295559-yc8q62z8	182	20	debris	debris	NN
cord-295559-yc8q62z8	182	21	,	,	,
cord-295559-yc8q62z8	182	22	and	and	CC
cord-295559-yc8q62z8	182	23	passed	pass	VBD
cord-295559-yc8q62z8	182	24	through	through	IN
cord-295559-yc8q62z8	182	25	a	a	DT
cord-295559-yc8q62z8	182	26	0.45	0.45	CD
cord-295559-yc8q62z8	182	27	µm	µm	NN
cord-295559-yc8q62z8	182	28	filter	filter	NN
cord-295559-yc8q62z8	182	29	.	.	.
cord-295559-yc8q62z8	183	1	To	to	TO
cord-295559-yc8q62z8	183	2	quantitate	quantitate	VB
cord-295559-yc8q62z8	183	3	entry	entry	NN
cord-295559-yc8q62z8	183	4	of	of	IN
cord-295559-yc8q62z8	183	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	183	6	into	into	IN
cord-295559-yc8q62z8	183	7	different	different	JJ
cord-295559-yc8q62z8	183	8	cell	cell	NN
cord-295559-yc8q62z8	183	9	types	type	NNS
cord-295559-yc8q62z8	183	10	,	,	,
cord-295559-yc8q62z8	183	11	250µl	250µl	NN
cord-295559-yc8q62z8	183	12	of	of	IN
cord-295559-yc8q62z8	183	13	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	183	14	with	with	IN
cord-295559-yc8q62z8	183	15	8	8	CD
cord-295559-yc8q62z8	183	16	µg	µg	NN
cord-295559-yc8q62z8	183	17	/	/	SYM
cord-295559-yc8q62z8	183	18	ml	ml	NNS
cord-295559-yc8q62z8	183	19	of	of	IN
cord-295559-yc8q62z8	183	20	polybrene	polybrene	NNP
cord-295559-yc8q62z8	183	21	(	(	-LRB-
cord-295559-yc8q62z8	183	22	Sigma	Sigma	NNP
cord-295559-yc8q62z8	183	23	)	)	-RRB-
cord-295559-yc8q62z8	183	24	was	be	VBD
cord-295559-yc8q62z8	183	25	inoculated	inoculate	VBN
cord-295559-yc8q62z8	183	26	onto	onto	IN
cord-295559-yc8q62z8	183	27	cells	cell	NNS
cord-295559-yc8q62z8	183	28	in	in	IN
cord-295559-yc8q62z8	183	29	24-well	24-well	CD
cord-295559-yc8q62z8	183	30	plates	plate	NNS
cord-295559-yc8q62z8	183	31	,	,	,
cord-295559-yc8q62z8	183	32	incubated	incubate	VBN
cord-295559-yc8q62z8	183	33	overnight	overnight	RB
cord-295559-yc8q62z8	183	34	at	at	IN
cord-295559-yc8q62z8	183	35	37	37	CD
cord-295559-yc8q62z8	183	36	°	°	NN
cord-295559-yc8q62z8	183	37	C	c	NN
cord-295559-yc8q62z8	183	38	,	,	,
cord-295559-yc8q62z8	183	39	and	and	CC
cord-295559-yc8q62z8	183	40	cells	cell	NNS
cord-295559-yc8q62z8	183	41	were	be	VBD
cord-295559-yc8q62z8	183	42	fed	feed	VBN
cord-295559-yc8q62z8	183	43	with	with	IN
cord-295559-yc8q62z8	183	44	fresh	fresh	JJ
cord-295559-yc8q62z8	183	45	medium	medium	NN
cord-295559-yc8q62z8	183	46	.	.	.
cord-295559-yc8q62z8	184	1	At	at	IN
cord-295559-yc8q62z8	184	2	40hr	40hr	JJ
cord-295559-yc8q62z8	184	3	post	post	NN
cord-295559-yc8q62z8	184	4	inoculation	inoculation	NN
cord-295559-yc8q62z8	184	5	(	(	-LRB-
cord-295559-yc8q62z8	184	6	pi	pi	NN
cord-295559-yc8q62z8	184	7	)	)	-RRB-
cord-295559-yc8q62z8	184	8	cells	cell	NNS
cord-295559-yc8q62z8	184	9	were	be	VBD
cord-295559-yc8q62z8	184	10	lysed	lyse	VBN
cord-295559-yc8q62z8	184	11	at	at	IN
cord-295559-yc8q62z8	184	12	room	room	NN
cord-295559-yc8q62z8	184	13	temperature	temperature	NN
cord-295559-yc8q62z8	184	14	with	with	IN
cord-295559-yc8q62z8	184	15	120µl	120µl	NN
cord-295559-yc8q62z8	184	16	of	of	IN
cord-295559-yc8q62z8	184	17	medium	medium	NN
cord-295559-yc8q62z8	184	18	with	with	IN
cord-295559-yc8q62z8	184	19	an	an	DT
cord-295559-yc8q62z8	184	20	equal	equal	JJ
cord-295559-yc8q62z8	184	21	volume	volume	NN
cord-295559-yc8q62z8	184	22	of	of	IN
cord-295559-yc8q62z8	184	23	Steady	Steady	NNP
cord-295559-yc8q62z8	184	24	-	-	HYPH
cord-295559-yc8q62z8	184	25	glo	glo	NNP
cord-295559-yc8q62z8	184	26	(	(	-LRB-
cord-295559-yc8q62z8	184	27	Promega	Promega	NNP
cord-295559-yc8q62z8	184	28	,	,	,
cord-295559-yc8q62z8	184	29	Madison	Madison	NNP
cord-295559-yc8q62z8	184	30	,	,	,
cord-295559-yc8q62z8	184	31	WI	WI	NNP
cord-295559-yc8q62z8	184	32	)	)	-RRB-
cord-295559-yc8q62z8	184	33	.	.	.
cord-295559-yc8q62z8	185	1	Transduction	transduction	NN
cord-295559-yc8q62z8	185	2	efficiency	efficiency	NN
cord-295559-yc8q62z8	185	3	was	be	VBD
cord-295559-yc8q62z8	185	4	monitored	monitor	VBN
cord-295559-yc8q62z8	185	5	by	by	IN
cord-295559-yc8q62z8	185	6	quantitation	quantitation	NN
cord-295559-yc8q62z8	185	7	of	of	IN
cord-295559-yc8q62z8	185	8	luciferase	luciferase	NN
cord-295559-yc8q62z8	185	9	activity	activity	NN
cord-295559-yc8q62z8	185	10	.	.	.
cord-295559-yc8q62z8	186	1	Living	living	NN
cord-295559-yc8q62z8	186	2	cells	cell	NNS
cord-295559-yc8q62z8	186	3	transduced	transduce	VBN
cord-295559-yc8q62z8	186	4	by	by	IN
cord-295559-yc8q62z8	186	5	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	186	6	were	be	VBD
cord-295559-yc8q62z8	186	7	detected	detect	VBN
cord-295559-yc8q62z8	186	8	by	by	IN
cord-295559-yc8q62z8	186	9	GFP	GFP	NNP
cord-295559-yc8q62z8	186	10	expression	expression	NN
cord-295559-yc8q62z8	186	11	.	.	.
cord-295559-yc8q62z8	187	1	For	for	IN
cord-295559-yc8q62z8	187	2	all	all	DT
cord-295559-yc8q62z8	187	3	experiments	experiment	NNS
cord-295559-yc8q62z8	187	4	triplicate	triplicate	VBP
cord-295559-yc8q62z8	187	5	samples	sample	NNS
cord-295559-yc8q62z8	187	6	were	be	VBD
cord-295559-yc8q62z8	187	7	analyzed	analyze	VBN
cord-295559-yc8q62z8	187	8	,	,	,
cord-295559-yc8q62z8	187	9	data	datum	NNS
cord-295559-yc8q62z8	187	10	are	be	VBP
cord-295559-yc8q62z8	187	11	representative	representative	JJ
cord-295559-yc8q62z8	187	12	of	of	IN
cord-295559-yc8q62z8	187	13	two	two	CD
cord-295559-yc8q62z8	187	14	or	or	CC
cord-295559-yc8q62z8	187	15	more	more	JJR
cord-295559-yc8q62z8	187	16	experiments	experiment	NNS
cord-295559-yc8q62z8	187	17	,	,	,
cord-295559-yc8q62z8	187	18	and	and	CC
cord-295559-yc8q62z8	187	19	the	the	DT
cord-295559-yc8q62z8	187	20	standard	standard	JJ
cord-295559-yc8q62z8	187	21	error	error	NN
cord-295559-yc8q62z8	187	22	is	be	VBZ
cord-295559-yc8q62z8	187	23	shown	show	VBN
cord-295559-yc8q62z8	187	24	.	.	.
cord-295559-yc8q62z8	188	1	Pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	188	2	with	with	IN
cord-295559-yc8q62z8	188	3	MERS	MERS	NNP
cord-295559-yc8q62z8	188	4	-	-	HYPH
cord-295559-yc8q62z8	188	5	CoV	cov	NN
cord-295559-yc8q62z8	188	6	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	188	7	,	,	,
cord-295559-yc8q62z8	188	8	SARS	SARS	NNP
cord-295559-yc8q62z8	188	9	SΔ19	SΔ19	NNP
cord-295559-yc8q62z8	188	10	,	,	,
cord-295559-yc8q62z8	188	11	or	or	CC
cord-295559-yc8q62z8	188	12	VSVg	vsvg	NN
cord-295559-yc8q62z8	188	13	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	188	14	or	or	CC
cord-295559-yc8q62z8	188	15	control	control	NN
cord-295559-yc8q62z8	188	16	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	188	17	with	with	IN
cord-295559-yc8q62z8	188	18	no	no	DT
cord-295559-yc8q62z8	188	19	spike	spike	NN
cord-295559-yc8q62z8	188	20	were	be	VBD
cord-295559-yc8q62z8	188	21	centrifuged	centrifuge	VBN
cord-295559-yc8q62z8	188	22	through	through	IN
cord-295559-yc8q62z8	188	23	a	a	DT
cord-295559-yc8q62z8	188	24	20	20	CD
cord-295559-yc8q62z8	188	25	%	%	NN
cord-295559-yc8q62z8	188	26	sucrose	sucrose	NN
cord-295559-yc8q62z8	188	27	cushion	cushion	NN
cord-295559-yc8q62z8	188	28	at	at	IN
cord-295559-yc8q62z8	188	29	30,000	30,000	CD
cord-295559-yc8q62z8	188	30	rpm	rpm	NN
cord-295559-yc8q62z8	188	31	at	at	IN
cord-295559-yc8q62z8	188	32	4	4	CD
cord-295559-yc8q62z8	188	33	°	°	NN
cord-295559-yc8q62z8	188	34	C	c	NN
cord-295559-yc8q62z8	188	35	for	for	IN
cord-295559-yc8q62z8	188	36	3	3	CD
cord-295559-yc8q62z8	188	37	h	h	NN
cord-295559-yc8q62z8	188	38	in	in	IN
cord-295559-yc8q62z8	188	39	a	a	DT
cord-295559-yc8q62z8	188	40	Beckman	Beckman	NNP
cord-295559-yc8q62z8	188	41	SW41	SW41	NNP
cord-295559-yc8q62z8	188	42	rotor	rotor	NN
cord-295559-yc8q62z8	188	43	[	[	-LRB-
cord-295559-yc8q62z8	188	44	71	71	CD
cord-295559-yc8q62z8	188	45	]	]	-RRB-
cord-295559-yc8q62z8	188	46	.	.	.
cord-295559-yc8q62z8	189	1	Spike	spike	NN
cord-295559-yc8q62z8	189	2	proteins	protein	NNS
cord-295559-yc8q62z8	189	3	in	in	IN
cord-295559-yc8q62z8	189	4	the	the	DT
cord-295559-yc8q62z8	189	5	virions	virion	NNS
cord-295559-yc8q62z8	189	6	were	be	VBD
cord-295559-yc8q62z8	189	7	separated	separate	VBN
cord-295559-yc8q62z8	189	8	on	on	IN
cord-295559-yc8q62z8	189	9	4	4	CD
cord-295559-yc8q62z8	189	10	-	-	SYM
cord-295559-yc8q62z8	189	11	15	15	CD
cord-295559-yc8q62z8	189	12	%	%	NN
cord-295559-yc8q62z8	189	13	SDS	SDS	NNP
cord-295559-yc8q62z8	189	14	PAGE	PAGE	NNP
cord-295559-yc8q62z8	189	15	,	,	,
cord-295559-yc8q62z8	189	16	blotted	blot	VBN
cord-295559-yc8q62z8	189	17	to	to	IN
cord-295559-yc8q62z8	189	18	nitrocellulose	nitrocellulose	NN
cord-295559-yc8q62z8	189	19	and	and	CC
cord-295559-yc8q62z8	189	20	detected	detect	VBN
cord-295559-yc8q62z8	189	21	with	with	IN
cord-295559-yc8q62z8	189	22	mouse	mouse	NN
cord-295559-yc8q62z8	189	23	anti	anti	JJ
cord-295559-yc8q62z8	189	24	-	-	JJ
cord-295559-yc8q62z8	189	25	FLAG	flag	JJ
cord-295559-yc8q62z8	189	26	antibody	antibody	NN
cord-295559-yc8q62z8	189	27	M2	M2	NNP
cord-295559-yc8q62z8	189	28	(	(	-LRB-
cord-295559-yc8q62z8	189	29	Sigma	Sigma	NNP
cord-295559-yc8q62z8	189	30	,	,	,
cord-295559-yc8q62z8	189	31	St	St	NNP
cord-295559-yc8q62z8	189	32	Louis	Louis	NNP
cord-295559-yc8q62z8	189	33	,	,	,
cord-295559-yc8q62z8	189	34	MO	MO	NNP
cord-295559-yc8q62z8	189	35	)	)	-RRB-
cord-295559-yc8q62z8	189	36	for	for	IN
cord-295559-yc8q62z8	189	37	MERS	MERS	NNP
cord-295559-yc8q62z8	189	38	-	-	HYPH
cord-295559-yc8q62z8	189	39	CoV	cov	NN
cord-295559-yc8q62z8	189	40	SΔ16	SΔ16	NNP
cord-295559-yc8q62z8	189	41	,	,	,
cord-295559-yc8q62z8	189	42	or	or	CC
cord-295559-yc8q62z8	189	43	polyclonal	polyclonal	JJ
cord-295559-yc8q62z8	189	44	goat	goat	NN
cord-295559-yc8q62z8	189	45	antibody	antibody	NN
cord-295559-yc8q62z8	189	46	AO4	AO4	NNP
cord-295559-yc8q62z8	189	47	to	to	IN
cord-295559-yc8q62z8	189	48	purified	purify	VBN
cord-295559-yc8q62z8	189	49	spikes	spike	NNS
cord-295559-yc8q62z8	189	50	from	from	IN
cord-295559-yc8q62z8	189	51	detergent	detergent	NN
cord-295559-yc8q62z8	189	52	-	-	HYPH
cord-295559-yc8q62z8	189	53	disrupted	disrupt	VBN
cord-295559-yc8q62z8	189	54	MHV-59	MHV-59	NNP
cord-295559-yc8q62z8	189	55	virions	virion	NNS
cord-295559-yc8q62z8	189	56	[	[	-LRB-
cord-295559-yc8q62z8	189	57	72	72	CD
cord-295559-yc8q62z8	189	58	]	]	-RRB-
cord-295559-yc8q62z8	189	59	,	,	,
cord-295559-yc8q62z8	189	60	followed	follow	VBN
cord-295559-yc8q62z8	189	61	by	by	IN
cord-295559-yc8q62z8	189	62	horseradish	horseradish	NN
cord-295559-yc8q62z8	189	63	peroxidase	peroxidase	NN
cord-295559-yc8q62z8	189	64	(	(	-LRB-
cord-295559-yc8q62z8	189	65	HRP)-conjugated	hrp)-conjugate	VBN
cord-295559-yc8q62z8	189	66	antibody	antibody	NN
cord-295559-yc8q62z8	189	67	to	to	TO
cord-295559-yc8q62z8	189	68	mouse	mouse	VB
cord-295559-yc8q62z8	189	69	or	or	CC
cord-295559-yc8q62z8	189	70	goat	goat	NNP
cord-295559-yc8q62z8	189	71	IgG	IgG	NNP
cord-295559-yc8q62z8	189	72	,	,	,
cord-295559-yc8q62z8	189	73	and	and	CC
cord-295559-yc8q62z8	189	74	visualized	visualize	VBD
cord-295559-yc8q62z8	189	75	with	with	IN
cord-295559-yc8q62z8	189	76	Chemiluminescent	Chemiluminescent	NNP
cord-295559-yc8q62z8	189	77	Reagent	Reagent	NNP
cord-295559-yc8q62z8	189	78	Plus	Plus	NNP
cord-295559-yc8q62z8	189	79	(	(	-LRB-
cord-295559-yc8q62z8	189	80	PerkinElmer	PerkinElmer	NNP
cord-295559-yc8q62z8	189	81	,	,	,
cord-295559-yc8q62z8	189	82	Boston	Boston	NNP
cord-295559-yc8q62z8	189	83	,	,	,
cord-295559-yc8q62z8	189	84	MA	MA	NNP
cord-295559-yc8q62z8	189	85	)	)	-RRB-
cord-295559-yc8q62z8	189	86	.	.	.
cord-295559-yc8q62z8	190	1	Vero	Vero	NNP
cord-295559-yc8q62z8	190	2	E6	E6	NNP
cord-295559-yc8q62z8	190	3	cells	cell	NNS
cord-295559-yc8q62z8	190	4	or	or	CC
cord-295559-yc8q62z8	190	5	LLCMK2	llcmk2	JJ
cord-295559-yc8q62z8	190	6	cells	cell	NNS
cord-295559-yc8q62z8	190	7	were	be	VBD
cord-295559-yc8q62z8	190	8	incubated	incubate	VBN
cord-295559-yc8q62z8	190	9	for	for	IN
cord-295559-yc8q62z8	190	10	1hr	1hr	CD
cord-295559-yc8q62z8	190	11	at	at	IN
cord-295559-yc8q62z8	190	12	37	37	CD
cord-295559-yc8q62z8	190	13	°	°	NN
cord-295559-yc8q62z8	190	14	C	c	NN
cord-295559-yc8q62z8	190	15	with	with	IN
cord-295559-yc8q62z8	190	16	medium	medium	NN
cord-295559-yc8q62z8	190	17	alone	alone	RB
cord-295559-yc8q62z8	190	18	or	or	CC
cord-295559-yc8q62z8	190	19	medium	medium	NN
cord-295559-yc8q62z8	190	20	containing	contain	VBG
cord-295559-yc8q62z8	190	21	either	either	CC
cord-295559-yc8q62z8	190	22	20mM	20mm	CD
cord-295559-yc8q62z8	190	23	NH	NH	NNP
cord-295559-yc8q62z8	190	24	4	4	CD
cord-295559-yc8q62z8	190	25	Cl	Cl	NNP
cord-295559-yc8q62z8	190	26	or	or	CC
cord-295559-yc8q62z8	190	27	200nM	200nM	NNP
cord-295559-yc8q62z8	190	28	bafilomycin	bafilomycin	VBZ
cord-295559-yc8q62z8	190	29	A	A	NNP
cord-295559-yc8q62z8	190	30	to	to	TO
cord-295559-yc8q62z8	190	31	inhibit	inhibit	VB
cord-295559-yc8q62z8	190	32	acidification	acidification	NN
cord-295559-yc8q62z8	190	33	of	of	IN
cord-295559-yc8q62z8	190	34	endosomes	endosome	NNS
cord-295559-yc8q62z8	190	35	,	,	,
cord-295559-yc8q62z8	190	36	and	and	CC
cord-295559-yc8q62z8	190	37	then	then	RB
cord-295559-yc8q62z8	190	38	spin	spin	NN
cord-295559-yc8q62z8	190	39	-	-	HYPH
cord-295559-yc8q62z8	190	40	inoculated	inoculate	VBN
cord-295559-yc8q62z8	190	41	with	with	IN
cord-295559-yc8q62z8	190	42	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	190	43	and	and	CC
cord-295559-yc8q62z8	190	44	no	no	DT
cord-295559-yc8q62z8	190	45	spike	spike	NN
cord-295559-yc8q62z8	190	46	controls	control	NNS
cord-295559-yc8q62z8	190	47	in	in	IN
cord-295559-yc8q62z8	190	48	the	the	DT
cord-295559-yc8q62z8	190	49	presence	presence	NN
cord-295559-yc8q62z8	190	50	of	of	IN
cord-295559-yc8q62z8	190	51	either	either	DT
cord-295559-yc8q62z8	190	52	20mM	20mm	CD
cord-295559-yc8q62z8	190	53	NH	NH	NNP
cord-295559-yc8q62z8	190	54	4	4	CD
cord-295559-yc8q62z8	190	55	Cl	Cl	NNP
cord-295559-yc8q62z8	190	56	or	or	CC
cord-295559-yc8q62z8	190	57	200nM	200nM	NNP
cord-295559-yc8q62z8	190	58	bafilomycin	bafilomycin	NNS
cord-295559-yc8q62z8	190	59	A	A	NNP
cord-295559-yc8q62z8	190	60	for	for	IN
cord-295559-yc8q62z8	190	61	90	90	CD
cord-295559-yc8q62z8	190	62	min	min	NN
cord-295559-yc8q62z8	190	63	at	at	IN
cord-295559-yc8q62z8	190	64	1,200	1,200	CD
cord-295559-yc8q62z8	190	65	g	g	NN
cord-295559-yc8q62z8	190	66	at	at	IN
cord-295559-yc8q62z8	190	67	4	4	CD
cord-295559-yc8q62z8	190	68	°	°	NN
cord-295559-yc8q62z8	190	69	C	c	NN
cord-295559-yc8q62z8	190	70	.	.	.
cord-295559-yc8q62z8	191	1	At	at	IN
cord-295559-yc8q62z8	191	2	40	40	CD
cord-295559-yc8q62z8	191	3	hr	hr	NN
cord-295559-yc8q62z8	191	4	pi	pi	NN
cord-295559-yc8q62z8	191	5	cells	cell	NNS
cord-295559-yc8q62z8	191	6	were	be	VBD
cord-295559-yc8q62z8	191	7	lysed	lyse	VBN
cord-295559-yc8q62z8	191	8	and	and	CC
cord-295559-yc8q62z8	191	9	luciferase	luciferase	JJ
cord-295559-yc8q62z8	191	10	activity	activity	NN
cord-295559-yc8q62z8	191	11	was	be	VBD
cord-295559-yc8q62z8	191	12	quantitated	quantitate	VBN
cord-295559-yc8q62z8	191	13	as	as	IN
cord-295559-yc8q62z8	191	14	a	a	DT
cord-295559-yc8q62z8	191	15	measure	measure	NN
cord-295559-yc8q62z8	191	16	of	of	IN
cord-295559-yc8q62z8	191	17	virus	virus	NN
cord-295559-yc8q62z8	191	18	entry	entry	NN
cord-295559-yc8q62z8	191	19	.	.	.
cord-295559-yc8q62z8	192	1	In	in	IN
cord-295559-yc8q62z8	192	2	Figure	Figure	NNP
cord-295559-yc8q62z8	192	3	3	3	CD
cord-295559-yc8q62z8	192	4	,	,	,
cord-295559-yc8q62z8	192	5	the	the	DT
cord-295559-yc8q62z8	192	6	luciferase	luciferase	NN
cord-295559-yc8q62z8	192	7	activities	activity	NNS
cord-295559-yc8q62z8	192	8	of	of	IN
cord-295559-yc8q62z8	192	9	Vero	Vero	NNP
cord-295559-yc8q62z8	192	10	E6	E6	NNP
cord-295559-yc8q62z8	192	11	cells	cell	NNS
cord-295559-yc8q62z8	192	12	transduced	transduce	VBN
cord-295559-yc8q62z8	192	13	with	with	IN
cord-295559-yc8q62z8	192	14	VSV-	VSV-	NNP
cord-295559-yc8q62z8	192	15	,	,	,
cord-295559-yc8q62z8	192	16	SARS-	SARS-	NNP
cord-295559-yc8q62z8	192	17	,	,	,
cord-295559-yc8q62z8	192	18	and	and	CC
cord-295559-yc8q62z8	192	19	MERS	MERS	NNP
cord-295559-yc8q62z8	192	20	-	-	HYPH
cord-295559-yc8q62z8	192	21	CoVSpseudovirions	CoVSpseudovirions	NNPS
cord-295559-yc8q62z8	192	22	without	without	IN
cord-295559-yc8q62z8	192	23	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	192	24	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	192	25	were	be	VBD
cord-295559-yc8q62z8	192	26	1x10	1x10	CD
cord-295559-yc8q62z8	192	27	6	6	CD
cord-295559-yc8q62z8	192	28	,	,	,
cord-295559-yc8q62z8	192	29	1.5	1.5	CD
cord-295559-yc8q62z8	192	30	-	-	SYM
cord-295559-yc8q62z8	192	31	2x10	2x10	CD
cord-295559-yc8q62z8	192	32	6	6	CD
cord-295559-yc8q62z8	192	33	,	,	,
cord-295559-yc8q62z8	192	34	and	and	CC
cord-295559-yc8q62z8	192	35	5	5	CD
cord-295559-yc8q62z8	192	36	-	-	SYM
cord-295559-yc8q62z8	192	37	6x10	6x10	CD
cord-295559-yc8q62z8	192	38	5	5	CD
cord-295559-yc8q62z8	192	39	,	,	,
cord-295559-yc8q62z8	192	40	respectively	respectively	RB
cord-295559-yc8q62z8	192	41	.	.	.
cord-295559-yc8q62z8	193	1	Monolayers	monolayer	NNS
cord-295559-yc8q62z8	193	2	of	of	IN
cord-295559-yc8q62z8	193	3	Vero	Vero	NNP
cord-295559-yc8q62z8	193	4	E6	E6	NNP
cord-295559-yc8q62z8	193	5	or	or	CC
cord-295559-yc8q62z8	193	6	LLCMK2	LLCMK2	NNP
cord-295559-yc8q62z8	193	7	cells	cell	NNS
cord-295559-yc8q62z8	193	8	were	be	VBD
cord-295559-yc8q62z8	193	9	incubated	incubate	VBN
cord-295559-yc8q62z8	193	10	with	with	IN
cord-295559-yc8q62z8	193	11	20mM	20mm	CD
cord-295559-yc8q62z8	193	12	NH	NH	NNP
cord-295559-yc8q62z8	193	13	4	4	CD
cord-295559-yc8q62z8	193	14	Cl	Cl	NNP
cord-295559-yc8q62z8	193	15	in	in	IN
cord-295559-yc8q62z8	193	16	medium	medium	NN
cord-295559-yc8q62z8	193	17	containing	contain	VBG
cord-295559-yc8q62z8	193	18	10	10	CD
cord-295559-yc8q62z8	193	19	%	%	NN
cord-295559-yc8q62z8	193	20	FBS	FBS	NNP
cord-295559-yc8q62z8	193	21	for	for	IN
cord-295559-yc8q62z8	193	22	1hr	1hr	CD
cord-295559-yc8q62z8	193	23	at	at	IN
cord-295559-yc8q62z8	193	24	37	37	CD
cord-295559-yc8q62z8	193	25	°	°	NN
cord-295559-yc8q62z8	193	26	C	c	NN
cord-295559-yc8q62z8	193	27	,	,	,
cord-295559-yc8q62z8	193	28	then	then	RB
cord-295559-yc8q62z8	193	29	shifted	shift	VBD
cord-295559-yc8q62z8	193	30	for	for	IN
cord-295559-yc8q62z8	193	31	15min	15min	NN
cord-295559-yc8q62z8	193	32	to	to	IN
cord-295559-yc8q62z8	193	33	4	4	CD
cord-295559-yc8q62z8	193	34	°	°	NN
cord-295559-yc8q62z8	193	35	C	c	NN
cord-295559-yc8q62z8	193	36	with	with	IN
cord-295559-yc8q62z8	194	1	40mM	40mm	CD
cord-295559-yc8q62z8	194	2	NH	NH	NNP
cord-295559-yc8q62z8	194	3	4	4	CD
cord-295559-yc8q62z8	194	4	Cl	Cl	NNP
cord-295559-yc8q62z8	194	5	.	.	.
cord-295559-yc8q62z8	194	6	Pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	194	7	were	be	VBD
cord-295559-yc8q62z8	194	8	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	194	9	to	to	IN
cord-295559-yc8q62z8	194	10	cells	cell	NNS
cord-295559-yc8q62z8	194	11	at	at	IN
cord-295559-yc8q62z8	194	12	4	4	CD
cord-295559-yc8q62z8	194	13	°	°	NN
cord-295559-yc8q62z8	194	14	C	c	NN
cord-295559-yc8q62z8	194	15	by	by	IN
cord-295559-yc8q62z8	194	16	spin	spin	NN
cord-295559-yc8q62z8	194	17	-	-	HYPH
cord-295559-yc8q62z8	194	18	inoculation	inoculation	NN
cord-295559-yc8q62z8	194	19	for	for	IN
cord-295559-yc8q62z8	194	20	90	90	CD
cord-295559-yc8q62z8	194	21	min	min	NN
cord-295559-yc8q62z8	194	22	at	at	IN
cord-295559-yc8q62z8	194	23	1,200	1,200	CD
cord-295559-yc8q62z8	194	24	g	g	NN
cord-295559-yc8q62z8	194	25	.	.	.
cord-295559-yc8q62z8	195	1	The	the	DT
cord-295559-yc8q62z8	195	2	virus	virus	NN
cord-295559-yc8q62z8	195	3	inocula	inocula	NN
cord-295559-yc8q62z8	195	4	were	be	VBD
cord-295559-yc8q62z8	195	5	removed	remove	VBN
cord-295559-yc8q62z8	195	6	and	and	CC
cord-295559-yc8q62z8	195	7	replaced	replace	VBN
cord-295559-yc8q62z8	195	8	with	with	IN
cord-295559-yc8q62z8	195	9	prewarmed	prewarmed	JJ
cord-295559-yc8q62z8	195	10	,	,	,
cord-295559-yc8q62z8	195	11	serum	serum	NN
cord-295559-yc8q62z8	195	12	-	-	HYPH
cord-295559-yc8q62z8	195	13	free	free	JJ
cord-295559-yc8q62z8	195	14	DMEM	dmem	NN
cord-295559-yc8q62z8	195	15	with	with	IN
cord-295559-yc8q62z8	195	16	or	or	CC
cord-295559-yc8q62z8	195	17	without	without	IN
cord-295559-yc8q62z8	195	18	20mM	20mm	CD
cord-295559-yc8q62z8	195	19	NH	NH	NNP
cord-295559-yc8q62z8	195	20	4	4	CD
cord-295559-yc8q62z8	195	21	Cl	Cl	NNP
cord-295559-yc8q62z8	195	22	.	.	.
cord-295559-yc8q62z8	196	1	After	after	IN
cord-295559-yc8q62z8	196	2	15min	15min	CD
cord-295559-yc8q62z8	196	3	at	at	IN
cord-295559-yc8q62z8	196	4	37	37	CD
cord-295559-yc8q62z8	196	5	°	°	NN
cord-295559-yc8q62z8	196	6	C	c	NN
cord-295559-yc8q62z8	196	7	,	,	,
cord-295559-yc8q62z8	196	8	the	the	DT
cord-295559-yc8q62z8	196	9	media	medium	NNS
cord-295559-yc8q62z8	196	10	were	be	VBD
cord-295559-yc8q62z8	196	11	replaced	replace	VBN
cord-295559-yc8q62z8	196	12	with	with	IN
cord-295559-yc8q62z8	196	13	serum	serum	NN
cord-295559-yc8q62z8	196	14	-	-	HYPH
cord-295559-yc8q62z8	196	15	free	free	JJ
cord-295559-yc8q62z8	196	16	DMEM	dmem	NN
cord-295559-yc8q62z8	196	17	with	with	IN
cord-295559-yc8q62z8	196	18	or	or	CC
cord-295559-yc8q62z8	196	19	without	without	IN
cord-295559-yc8q62z8	196	20	15	15	CD
cord-295559-yc8q62z8	196	21	µg	µg	NN
cord-295559-yc8q62z8	196	22	/	/	SYM
cord-295559-yc8q62z8	196	23	ml	ml	NN
cord-295559-yc8q62z8	196	24	of	of	IN
cord-295559-yc8q62z8	196	25	TPCK	TPCK	NNP
cord-295559-yc8q62z8	196	26	-	-	HYPH
cord-295559-yc8q62z8	196	27	trypsin	trypsin	NN
cord-295559-yc8q62z8	196	28	at	at	IN
cord-295559-yc8q62z8	196	29	room	room	NN
cord-295559-yc8q62z8	196	30	temperature	temperature	NN
cord-295559-yc8q62z8	196	31	to	to	TO
cord-295559-yc8q62z8	196	32	activate	activate	VB
cord-295559-yc8q62z8	196	33	the	the	DT
cord-295559-yc8q62z8	196	34	membrane	membrane	NN
cord-295559-yc8q62z8	196	35	fusing	fuse	VBG
cord-295559-yc8q62z8	196	36	activity	activity	NN
cord-295559-yc8q62z8	196	37	of	of	IN
cord-295559-yc8q62z8	196	38	the	the	DT
cord-295559-yc8q62z8	196	39	S	S	NNP
cord-295559-yc8q62z8	196	40	protein	protein	NN
cord-295559-yc8q62z8	196	41	on	on	IN
cord-295559-yc8q62z8	196	42	virions	virion	NNS
cord-295559-yc8q62z8	196	43	adsorbed	adsorb	VBN
cord-295559-yc8q62z8	196	44	to	to	IN
cord-295559-yc8q62z8	196	45	the	the	DT
cord-295559-yc8q62z8	196	46	plasma	plasma	NN
cord-295559-yc8q62z8	196	47	membrane	membrane	NN
cord-295559-yc8q62z8	196	48	.	.	.
cord-295559-yc8q62z8	197	1	Trypsin	Trypsin	NNP
cord-295559-yc8q62z8	197	2	activity	activity	NN
cord-295559-yc8q62z8	197	3	was	be	VBD
cord-295559-yc8q62z8	197	4	then	then	RB
cord-295559-yc8q62z8	197	5	inhibited	inhibit	VBN
cord-295559-yc8q62z8	197	6	by	by	IN
cord-295559-yc8q62z8	197	7	incubation	incubation	NN
cord-295559-yc8q62z8	197	8	for	for	IN
cord-295559-yc8q62z8	197	9	15	15	CD
cord-295559-yc8q62z8	197	10	min	min	NN
cord-295559-yc8q62z8	197	11	on	on	IN
cord-295559-yc8q62z8	197	12	ice	ice	NN
cord-295559-yc8q62z8	197	13	with	with	IN
cord-295559-yc8q62z8	197	14	75µg	75µg	NN
cord-295559-yc8q62z8	197	15	/	/	SYM
cord-295559-yc8q62z8	197	16	ml	ml	NN
cord-295559-yc8q62z8	197	17	of	of	IN
cord-295559-yc8q62z8	197	18	soybean	soybean	NN
cord-295559-yc8q62z8	197	19	trypsin	trypsin	NN
cord-295559-yc8q62z8	197	20	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	197	21	(	(	-LRB-
cord-295559-yc8q62z8	197	22	Worthington	Worthington	NNP
cord-295559-yc8q62z8	197	23	Biochemical	Biochemical	NNP
cord-295559-yc8q62z8	197	24	Corporation	Corporation	NNP
cord-295559-yc8q62z8	197	25	,	,	,
cord-295559-yc8q62z8	197	26	Lakewood	Lakewood	NNP
cord-295559-yc8q62z8	197	27	,	,	,
cord-295559-yc8q62z8	197	28	NJ	NJ	NNP
cord-295559-yc8q62z8	197	29	)	)	-RRB-
cord-295559-yc8q62z8	197	30	in	in	IN
cord-295559-yc8q62z8	197	31	DMEM	DMEM	NNP
cord-295559-yc8q62z8	197	32	with	with	IN
cord-295559-yc8q62z8	197	33	10	10	CD
cord-295559-yc8q62z8	197	34	%	%	NN
cord-295559-yc8q62z8	197	35	FBS	FBS	NNP
cord-295559-yc8q62z8	197	36	,	,	,
cord-295559-yc8q62z8	197	37	and	and	CC
cord-295559-yc8q62z8	197	38	cells	cell	NNS
cord-295559-yc8q62z8	197	39	were	be	VBD
cord-295559-yc8q62z8	197	40	incubated	incubate	VBN
cord-295559-yc8q62z8	197	41	overnight	overnight	RB
cord-295559-yc8q62z8	197	42	at	at	IN
cord-295559-yc8q62z8	197	43	37	37	CD
cord-295559-yc8q62z8	197	44	°	°	NN
cord-295559-yc8q62z8	197	45	C	c	NN
cord-295559-yc8q62z8	197	46	,	,	,
cord-295559-yc8q62z8	197	47	fed	feed	VBN
cord-295559-yc8q62z8	197	48	with	with	IN
cord-295559-yc8q62z8	197	49	fresh	fresh	JJ
cord-295559-yc8q62z8	197	50	medium	medium	NN
cord-295559-yc8q62z8	197	51	,	,	,
cord-295559-yc8q62z8	197	52	and	and	CC
cord-295559-yc8q62z8	197	53	incubated	incubate	VBN
cord-295559-yc8q62z8	197	54	at	at	IN
cord-295559-yc8q62z8	197	55	37	37	CD
cord-295559-yc8q62z8	197	56	°	°	NN
cord-295559-yc8q62z8	197	57	C	c	NN
cord-295559-yc8q62z8	197	58	.	.	.
cord-295559-yc8q62z8	198	1	At	at	IN
cord-295559-yc8q62z8	198	2	40	40	CD
cord-295559-yc8q62z8	198	3	hr	hr	NN
cord-295559-yc8q62z8	198	4	pi	pi	NN
cord-295559-yc8q62z8	198	5	,	,	,
cord-295559-yc8q62z8	198	6	virus	virus	NN
cord-295559-yc8q62z8	198	7	entry	entry	NN
cord-295559-yc8q62z8	198	8	was	be	VBD
cord-295559-yc8q62z8	198	9	quantitated	quantitate	VBN
cord-295559-yc8q62z8	198	10	by	by	IN
cord-295559-yc8q62z8	198	11	luciferase	luciferase	NN
cord-295559-yc8q62z8	198	12	activity	activity	NN
cord-295559-yc8q62z8	198	13	and	and	CC
cord-295559-yc8q62z8	198	14	cells	cell	NNS
cord-295559-yc8q62z8	198	15	were	be	VBD
cord-295559-yc8q62z8	198	16	photographed	photograph	VBN
cord-295559-yc8q62z8	198	17	to	to	TO
cord-295559-yc8q62z8	198	18	detect	detect	VB
cord-295559-yc8q62z8	198	19	viral	viral	JJ
cord-295559-yc8q62z8	198	20	cytopathic	cytopathic	JJ
cord-295559-yc8q62z8	198	21	effects	effect	NNS
cord-295559-yc8q62z8	198	22	.	.	.
cord-295559-yc8q62z8	199	1	Monolayers	monolayer	NNS
cord-295559-yc8q62z8	199	2	of	of	IN
cord-295559-yc8q62z8	199	3	Vero	Vero	NNP
cord-295559-yc8q62z8	199	4	E6	E6	NNP
cord-295559-yc8q62z8	199	5	cells	cell	NNS
cord-295559-yc8q62z8	199	6	or	or	CC
cord-295559-yc8q62z8	199	7	LLCMK2	llcmk2	JJ
cord-295559-yc8q62z8	199	8	cells	cell	NNS
cord-295559-yc8q62z8	199	9	were	be	VBD
cord-295559-yc8q62z8	199	10	preincubated	preincubate	VBN
cord-295559-yc8q62z8	199	11	for	for	IN
cord-295559-yc8q62z8	199	12	2	2	CD
cord-295559-yc8q62z8	199	13	hrs	hrs	NN
cord-295559-yc8q62z8	199	14	at	at	IN
cord-295559-yc8q62z8	199	15	37	37	CD
cord-295559-yc8q62z8	199	16	°	°	NN
cord-295559-yc8q62z8	199	17	C	c	NN
cord-295559-yc8q62z8	199	18	with	with	IN
cord-295559-yc8q62z8	199	19	either	either	DT
cord-295559-yc8q62z8	199	20	30µM	30µm	CD
cord-295559-yc8q62z8	199	21	of	of	IN
cord-295559-yc8q62z8	199	22	E64D	E64D	NNP
cord-295559-yc8q62z8	200	1	,	,	,
cord-295559-yc8q62z8	200	2	that	that	DT
cord-295559-yc8q62z8	200	3	inhibits	inhibit	VBZ
cord-295559-yc8q62z8	200	4	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	200	5	B	b	NN
cord-295559-yc8q62z8	200	6	,	,	,
cord-295559-yc8q62z8	200	7	H	H	NNP
cord-295559-yc8q62z8	200	8	,	,	,
cord-295559-yc8q62z8	200	9	L	l	NN
cord-295559-yc8q62z8	200	10	and	and	CC
cord-295559-yc8q62z8	200	11	calpain	calpain	NN
cord-295559-yc8q62z8	200	12	,	,	,
cord-295559-yc8q62z8	200	13	or	or	CC
cord-295559-yc8q62z8	200	14	10µM	10µm	CD
cord-295559-yc8q62z8	200	15	of	of	IN
cord-295559-yc8q62z8	200	16	specific	specific	JJ
cord-295559-yc8q62z8	200	17	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	200	18	L	l	NN
cord-295559-yc8q62z8	200	19	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	200	20	III	III	NNP
cord-295559-yc8q62z8	200	21	(	(	-LRB-
cord-295559-yc8q62z8	200	22	Millipore	Millipore	NNP
cord-295559-yc8q62z8	200	23	,	,	,
cord-295559-yc8q62z8	200	24	Billerica	Billerica	NNP
cord-295559-yc8q62z8	200	25	,	,	,
cord-295559-yc8q62z8	200	26	MA	MA	NNP
cord-295559-yc8q62z8	200	27	)	)	-RRB-
cord-295559-yc8q62z8	200	28	.	.	.
cord-295559-yc8q62z8	201	1	Pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	201	2	and	and	CC
cord-295559-yc8q62z8	201	3	no	no	DT
cord-295559-yc8q62z8	201	4	spike	spike	NN
cord-295559-yc8q62z8	201	5	controls	control	VBZ
cord-295559-yc8q62z8	201	6	with	with	IN
cord-295559-yc8q62z8	201	7	or	or	CC
cord-295559-yc8q62z8	201	8	without	without	IN
cord-295559-yc8q62z8	201	9	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	201	10	inhibitors	inhibitor	NNS
cord-295559-yc8q62z8	201	11	were	be	VBD
cord-295559-yc8q62z8	201	12	spin	spin	NN
cord-295559-yc8q62z8	201	13	-	-	HYPH
cord-295559-yc8q62z8	201	14	inoculated	inoculate	VBN
cord-295559-yc8q62z8	201	15	onto	onto	IN
cord-295559-yc8q62z8	201	16	the	the	DT
cord-295559-yc8q62z8	201	17	cells	cell	NNS
cord-295559-yc8q62z8	201	18	at	at	IN
cord-295559-yc8q62z8	201	19	4	4	CD
cord-295559-yc8q62z8	201	20	°	°	NN
cord-295559-yc8q62z8	201	21	C	c	NN
cord-295559-yc8q62z8	201	22	,	,	,
cord-295559-yc8q62z8	201	23	then	then	RB
cord-295559-yc8q62z8	201	24	incubated	incubate	VBN
cord-295559-yc8q62z8	201	25	at	at	IN
cord-295559-yc8q62z8	201	26	37	37	CD
cord-295559-yc8q62z8	201	27	°	°	NN
cord-295559-yc8q62z8	201	28	C	c	NN
cord-295559-yc8q62z8	201	29	for	for	IN
cord-295559-yc8q62z8	201	30	5	5	CD
cord-295559-yc8q62z8	201	31	hours	hour	NNS
cord-295559-yc8q62z8	201	32	with	with	IN
cord-295559-yc8q62z8	201	33	or	or	CC
cord-295559-yc8q62z8	201	34	without	without	IN
cord-295559-yc8q62z8	201	35	the	the	DT
cord-295559-yc8q62z8	201	36	endocytosis	endocytosis	NN
cord-295559-yc8q62z8	201	37	inhibitors	inhibitor	NNS
cord-295559-yc8q62z8	201	38	.	.	.
cord-295559-yc8q62z8	202	1	Cells	cell	NNS
cord-295559-yc8q62z8	202	2	were	be	VBD
cord-295559-yc8q62z8	202	3	then	then	RB
cord-295559-yc8q62z8	202	4	incubated	incubate	VBN
cord-295559-yc8q62z8	202	5	at	at	IN
cord-295559-yc8q62z8	202	6	37	37	CD
cord-295559-yc8q62z8	202	7	°	°	NN
cord-295559-yc8q62z8	202	8	C	c	NN
cord-295559-yc8q62z8	202	9	without	without	IN
cord-295559-yc8q62z8	202	10	inhibitors	inhibitor	NNS
cord-295559-yc8q62z8	202	11	,	,	,
cord-295559-yc8q62z8	202	12	and	and	CC
cord-295559-yc8q62z8	202	13	at	at	IN
cord-295559-yc8q62z8	202	14	40	40	CD
cord-295559-yc8q62z8	202	15	hr	hr	NN
cord-295559-yc8q62z8	202	16	pi	pi	NN
cord-295559-yc8q62z8	202	17	,	,	,
cord-295559-yc8q62z8	202	18	luciferase	luciferase	NN
cord-295559-yc8q62z8	202	19	activity	activity	NN
cord-295559-yc8q62z8	202	20	in	in	IN
cord-295559-yc8q62z8	202	21	lysed	lyse	VBN
cord-295559-yc8q62z8	202	22	cells	cell	NNS
cord-295559-yc8q62z8	202	23	was	be	VBD
cord-295559-yc8q62z8	202	24	determined	determine	VBN
cord-295559-yc8q62z8	202	25	.	.	.
cord-295559-yc8q62z8	203	1	293	293	CD
cord-295559-yc8q62z8	203	2	T	t	NN
cord-295559-yc8q62z8	203	3	cells	cell	NNS
cord-295559-yc8q62z8	203	4	in	in	IN
cord-295559-yc8q62z8	203	5	6-well	6-well	CD
cord-295559-yc8q62z8	203	6	plates	plate	NNS
cord-295559-yc8q62z8	203	7	were	be	VBD
cord-295559-yc8q62z8	203	8	transfected	transfecte	VBN
cord-295559-yc8q62z8	203	9	using	use	VBG
cord-295559-yc8q62z8	203	10	PEI	PEI	NNP
cord-295559-yc8q62z8	203	11	with	with	IN
cord-295559-yc8q62z8	203	12	3	3	CD
cord-295559-yc8q62z8	203	13	µg	µg	NN
cord-295559-yc8q62z8	203	14	of	of	IN
cord-295559-yc8q62z8	203	15	either	either	DT
cord-295559-yc8q62z8	203	16	empty	empty	JJ
cord-295559-yc8q62z8	203	17	vector	vector	NN
cord-295559-yc8q62z8	203	18	or	or	CC
cord-295559-yc8q62z8	203	19	MERS	MERS	NNP
cord-295559-yc8q62z8	203	20	-	-	HYPH
cord-295559-yc8q62z8	203	21	CoV	CoV	NNP
cord-295559-yc8q62z8	203	22	S∆16	S∆16	NNP
cord-295559-yc8q62z8	203	23	plasmid	plasmid	NN
cord-295559-yc8q62z8	203	24	.	.	.
cord-295559-yc8q62z8	204	1	For	for	IN
cord-295559-yc8q62z8	204	2	brief	brief	JJ
cord-295559-yc8q62z8	204	3	trypsin	trypsin	NN
cord-295559-yc8q62z8	204	4	pre	pre	NN
cord-295559-yc8q62z8	204	5	-	-	NN
cord-295559-yc8q62z8	204	6	treatment	treatment	JJ
cord-295559-yc8q62z8	204	7	,	,	,
cord-295559-yc8q62z8	204	8	cells	cell	NNS
cord-295559-yc8q62z8	204	9	were	be	VBD
cord-295559-yc8q62z8	204	10	lifted	lift	VBN
cord-295559-yc8q62z8	204	11	with	with	IN
cord-295559-yc8q62z8	204	12	1mM	1mm	CD
cord-295559-yc8q62z8	204	13	EDTA	EDTA	NNP
cord-295559-yc8q62z8	204	14	in	in	IN
cord-295559-yc8q62z8	204	15	PBS	PBS	NNP
cord-295559-yc8q62z8	204	16	and	and	CC
cord-295559-yc8q62z8	204	17	washed	wash	VBD
cord-295559-yc8q62z8	204	18	,	,	,
cord-295559-yc8q62z8	204	19	then	then	RB
cord-295559-yc8q62z8	204	20	incubated	incubate	VBN
cord-295559-yc8q62z8	204	21	on	on	IN
cord-295559-yc8q62z8	204	22	ice	ice	NN
cord-295559-yc8q62z8	204	23	with	with	IN
cord-295559-yc8q62z8	204	24	20	20	CD
cord-295559-yc8q62z8	204	25	µg	µg	NN
cord-295559-yc8q62z8	204	26	/	/	SYM
cord-295559-yc8q62z8	204	27	ml	ml	NNS
cord-295559-yc8q62z8	204	28	of	of	IN
cord-295559-yc8q62z8	204	29	TPCK	TPCK	NNP
cord-295559-yc8q62z8	204	30	trypsin	trypsin	NN
cord-295559-yc8q62z8	204	31	or	or	CC
cord-295559-yc8q62z8	204	32	control	control	NN
cord-295559-yc8q62z8	204	33	medium	medium	NN
cord-295559-yc8q62z8	204	34	for	for	IN
cord-295559-yc8q62z8	204	35	20	20	CD
cord-295559-yc8q62z8	204	36	min	min	NN
cord-295559-yc8q62z8	204	37	.	.	.
cord-295559-yc8q62z8	205	1	Typsin	typsin	NN
cord-295559-yc8q62z8	205	2	activity	activity	NN
cord-295559-yc8q62z8	205	3	was	be	VBD
cord-295559-yc8q62z8	205	4	then	then	RB
cord-295559-yc8q62z8	205	5	inhibited	inhibit	VBN
cord-295559-yc8q62z8	205	6	by	by	IN
cord-295559-yc8q62z8	205	7	incubation	incubation	NN
cord-295559-yc8q62z8	205	8	with	with	IN
cord-295559-yc8q62z8	205	9	a	a	DT
cord-295559-yc8q62z8	205	10	five	five	CD
cord-295559-yc8q62z8	205	11	-	-	JJ
cord-295559-yc8q62z8	205	12	fold	fold	JJ
cord-295559-yc8q62z8	205	13	excess	excess	NN
cord-295559-yc8q62z8	205	14	of	of	IN
cord-295559-yc8q62z8	205	15	soybean	soybean	NN
cord-295559-yc8q62z8	205	16	trypsin	trypsin	NN
cord-295559-yc8q62z8	205	17	inhibitor	inhibitor	NN
cord-295559-yc8q62z8	205	18	for	for	IN
cord-295559-yc8q62z8	205	19	15min	15min	NNP
cord-295559-yc8q62z8	205	20	.	.	.
cord-295559-yc8q62z8	206	1	The	the	DT
cord-295559-yc8q62z8	206	2	trypsin	trypsin	NN
cord-295559-yc8q62z8	206	3	-	-	HYPH
cord-295559-yc8q62z8	206	4	pretreated	pretreate	VBN
cord-295559-yc8q62z8	206	5	293	293	CD
cord-295559-yc8q62z8	206	6	T	T	NNP
cord-295559-yc8q62z8	206	7	cells	cell	NNS
cord-295559-yc8q62z8	206	8	and	and	CC
cord-295559-yc8q62z8	206	9	control	control	NN
cord-295559-yc8q62z8	206	10	cells	cell	NNS
cord-295559-yc8q62z8	206	11	were	be	VBD
cord-295559-yc8q62z8	206	12	then	then	RB
cord-295559-yc8q62z8	206	13	layered	layer	VBN
cord-295559-yc8q62z8	206	14	over	over	IN
cord-295559-yc8q62z8	206	15	monolayers	monolayer	NNS
cord-295559-yc8q62z8	206	16	of	of	IN
cord-295559-yc8q62z8	206	17	Vero	Vero	NNP
cord-295559-yc8q62z8	206	18	E6	E6	NNP
cord-295559-yc8q62z8	206	19	cells	cell	NNS
cord-295559-yc8q62z8	206	20	and	and	CC
cord-295559-yc8q62z8	206	21	incubated	incubate	VBN
cord-295559-yc8q62z8	206	22	for	for	IN
cord-295559-yc8q62z8	206	23	20	20	CD
cord-295559-yc8q62z8	206	24	hr	hr	NN
cord-295559-yc8q62z8	206	25	.	.	.
cord-295559-yc8q62z8	207	1	Syncytia	syncytia	NN
cord-295559-yc8q62z8	207	2	formation	formation	NN
cord-295559-yc8q62z8	207	3	was	be	VBD
cord-295559-yc8q62z8	207	4	detected	detect	VBN
cord-295559-yc8q62z8	207	5	by	by	IN
cord-295559-yc8q62z8	207	6	phase	phase	NN
cord-295559-yc8q62z8	207	7	contrast	contrast	NN
cord-295559-yc8q62z8	207	8	microscopy	microscopy	NNS
cord-295559-yc8q62z8	207	9	or	or	CC
cord-295559-yc8q62z8	207	10	by	by	IN
cord-295559-yc8q62z8	207	11	imaging	image	VBG
cord-295559-yc8q62z8	207	12	fixed	fix	VBN
cord-295559-yc8q62z8	207	13	cells	cell	NNS
cord-295559-yc8q62z8	207	14	stained	stain	VBN
cord-295559-yc8q62z8	207	15	with	with	IN
cord-295559-yc8q62z8	207	16	crystal	crystal	JJ
cord-295559-yc8q62z8	207	17	violet	violet	NN
cord-295559-yc8q62z8	207	18	.	.	.
cord-295559-yc8q62z8	208	1	Figure	figure	NN
cord-295559-yc8q62z8	208	2	S1	s1	NN
cord-295559-yc8q62z8	208	3	.	.	.
cord-295559-yc8q62z8	209	1	Detection	detection	NN
cord-295559-yc8q62z8	209	2	of	of	IN
cord-295559-yc8q62z8	209	3	trypsin	trypsin	NN
cord-295559-yc8q62z8	209	4	-	-	HYPH
cord-295559-yc8q62z8	209	5	cleaved	cleave	VBN
cord-295559-yc8q62z8	209	6	MERS	MERS	NNP
cord-295559-yc8q62z8	209	7	-	-	HYPH
cord-295559-yc8q62z8	209	8	CoV	CoV	NNP
cord-295559-yc8q62z8	209	9	S	S	NNP
cord-295559-yc8q62z8	209	10	protein	protein	NN
cord-295559-yc8q62z8	209	11	on	on	IN
cord-295559-yc8q62z8	209	12	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	209	13	by	by	IN
cord-295559-yc8q62z8	209	14	antibody	antibody	NN
cord-295559-yc8q62z8	209	15	to	to	IN
cord-295559-yc8q62z8	209	16	MHV	MHV	NNP
cord-295559-yc8q62z8	209	17	S	S	NNP
cord-295559-yc8q62z8	209	18	protein	protein	NN
cord-295559-yc8q62z8	209	19	.	.	.
cord-295559-yc8q62z8	210	1	Pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	210	2	containing	contain	VBG
cord-295559-yc8q62z8	210	3	either	either	CC
cord-295559-yc8q62z8	210	4	MERS	MERS	NNP
cord-295559-yc8q62z8	210	5	-	-	HYPH
cord-295559-yc8q62z8	210	6	CoV	CoV	NNP
cord-295559-yc8q62z8	210	7	S	S	NNP
cord-295559-yc8q62z8	210	8	protein	protein	NN
cord-295559-yc8q62z8	210	9	or	or	CC
cord-295559-yc8q62z8	210	10	no	no	DT
cord-295559-yc8q62z8	210	11	spike	spike	NN
cord-295559-yc8q62z8	210	12	(	(	-LRB-
cord-295559-yc8q62z8	210	13	control	control	NN
cord-295559-yc8q62z8	210	14	)	)	-RRB-
cord-295559-yc8q62z8	210	15	were	be	VBD
cord-295559-yc8q62z8	210	16	incubated	incubate	VBN
cord-295559-yc8q62z8	210	17	with	with	IN
cord-295559-yc8q62z8	210	18	20	20	CD
cord-295559-yc8q62z8	210	19	µg	µg	NN
cord-295559-yc8q62z8	210	20	/	/	SYM
cord-295559-yc8q62z8	210	21	ml	ml	NNS
cord-295559-yc8q62z8	210	22	of	of	IN
cord-295559-yc8q62z8	210	23	trypsin	trypsin	NN
cord-295559-yc8q62z8	210	24	either	either	CC
cord-295559-yc8q62z8	210	25	at	at	IN
cord-295559-yc8q62z8	210	26	4	4	CD
cord-295559-yc8q62z8	210	27	°	°	NN
cord-295559-yc8q62z8	210	28	C	c	NN
cord-295559-yc8q62z8	210	29	or	or	CC
cord-295559-yc8q62z8	210	30	37	37	CD
cord-295559-yc8q62z8	210	31	°	°	NN
cord-295559-yc8q62z8	210	32	C	c	NN
cord-295559-yc8q62z8	210	33	for	for	IN
cord-295559-yc8q62z8	210	34	20	20	CD
cord-295559-yc8q62z8	210	35	min	min	NN
cord-295559-yc8q62z8	210	36	.	.	.
cord-295559-yc8q62z8	211	1	After	after	IN
cord-295559-yc8q62z8	211	2	digestion	digestion	NN
cord-295559-yc8q62z8	211	3	,	,	,
cord-295559-yc8q62z8	211	4	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	211	5	on	on	IN
cord-295559-yc8q62z8	211	6	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	211	7	were	be	VBD
cord-295559-yc8q62z8	211	8	analyzed	analyze	VBN
cord-295559-yc8q62z8	211	9	by	by	IN
cord-295559-yc8q62z8	211	10	immunoblot	immunoblot	NNP
cord-295559-yc8q62z8	211	11	using	use	VBG
cord-295559-yc8q62z8	211	12	AO4	AO4	NNP
cord-295559-yc8q62z8	211	13	antibody	antibody	NN
cord-295559-yc8q62z8	211	14	to	to	IN
cord-295559-yc8q62z8	211	15	the	the	DT
cord-295559-yc8q62z8	211	16	S	S	NNP
cord-295559-yc8q62z8	211	17	protein	protein	NN
cord-295559-yc8q62z8	211	18	of	of	IN
cord-295559-yc8q62z8	211	19	murine	murine	JJ
cord-295559-yc8q62z8	211	20	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	211	21	MHV	MHV	NNP
cord-295559-yc8q62z8	211	22	-	-	HYPH
cord-295559-yc8q62z8	211	23	A59	A59	NNP
cord-295559-yc8q62z8	211	24	that	that	WDT
cord-295559-yc8q62z8	211	25	cross	cross	NN
cord-295559-yc8q62z8	211	26	-	-	VBZ
cord-295559-yc8q62z8	211	27	reacts	react	VBZ
cord-295559-yc8q62z8	211	28	with	with	IN
cord-295559-yc8q62z8	211	29	MERS	MERS	NNP
cord-295559-yc8q62z8	211	30	-	-	HYPH
cord-295559-yc8q62z8	211	31	CoV	CoV	NNP
cord-295559-yc8q62z8	211	32	S	S	NNP
cord-295559-yc8q62z8	211	33	protein	protein	NN
cord-295559-yc8q62z8	211	34	.	.	.
cord-295559-yc8q62z8	212	1	Lanes	lane	NNS
cord-295559-yc8q62z8	212	2	1	1	CD
cord-295559-yc8q62z8	212	3	to	to	IN
cord-295559-yc8q62z8	212	4	3	3	CD
cord-295559-yc8q62z8	212	5	:	:	:
cord-295559-yc8q62z8	212	6	No	no	DT
cord-295559-yc8q62z8	212	7	spike	spike	NN
cord-295559-yc8q62z8	212	8	control	control	NN
cord-295559-yc8q62z8	212	9	;	;	:
cord-295559-yc8q62z8	212	10	Lanes	lane	NNS
cord-295559-yc8q62z8	212	11	4	4	CD
cord-295559-yc8q62z8	212	12	to	to	IN
cord-295559-yc8q62z8	212	13	6	6	CD
cord-295559-yc8q62z8	212	14	:	:	:
cord-295559-yc8q62z8	212	15	MERS	MERS	NNP
cord-295559-yc8q62z8	212	16	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	212	17	;	;	:
cord-295559-yc8q62z8	212	18	Lanes	lane	NNS
cord-295559-yc8q62z8	212	19	1	1	CD
cord-295559-yc8q62z8	212	20	and	and	CC
cord-295559-yc8q62z8	212	21	4	4	CD
cord-295559-yc8q62z8	212	22	:	:	:
cord-295559-yc8q62z8	212	23	No	no	DT
cord-295559-yc8q62z8	212	24	trypsin	trypsin	NN
cord-295559-yc8q62z8	212	25	;	;	:
cord-295559-yc8q62z8	212	26	Lanes	lane	NNS
cord-295559-yc8q62z8	212	27	2	2	CD
cord-295559-yc8q62z8	212	28	and	and	CC
cord-295559-yc8q62z8	212	29	5	5	CD
cord-295559-yc8q62z8	212	30	:	:	:
cord-295559-yc8q62z8	212	31	trypsin	trypsin	NN
cord-295559-yc8q62z8	212	32	at	at	IN
cord-295559-yc8q62z8	212	33	4	4	CD
cord-295559-yc8q62z8	212	34	°	°	NN
cord-295559-yc8q62z8	212	35	C	c	NN
cord-295559-yc8q62z8	212	36	;	;	:
cord-295559-yc8q62z8	212	37	Lane	Lane	NNP
cord-295559-yc8q62z8	212	38	3	3	CD
cord-295559-yc8q62z8	212	39	and	and	CC
cord-295559-yc8q62z8	212	40	5	5	CD
cord-295559-yc8q62z8	212	41	:	:	:
cord-295559-yc8q62z8	212	42	trypsin	trypsin	VB
cord-295559-yc8q62z8	212	43	at	at	IN
cord-295559-yc8q62z8	212	44	37	37	CD
cord-295559-yc8q62z8	212	45	°	°	NN
cord-295559-yc8q62z8	212	46	C	c	NN
cord-295559-yc8q62z8	212	47	.	.	.
cord-295559-yc8q62z8	213	1	The	the	DT
cord-295559-yc8q62z8	213	2	band	band	NN
cord-295559-yc8q62z8	213	3	at	at	IN
cord-295559-yc8q62z8	213	4	~90kDa	~90kDa	NNP
cord-295559-yc8q62z8	213	5	was	be	VBD
cord-295559-yc8q62z8	213	6	seen	see	VBN
cord-295559-yc8q62z8	213	7	in	in	IN
cord-295559-yc8q62z8	213	8	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	213	9	without	without	IN
cord-295559-yc8q62z8	213	10	spike	spike	NN
cord-295559-yc8q62z8	213	11	,	,	,
cord-295559-yc8q62z8	213	12	indicating	indicate	VBG
cord-295559-yc8q62z8	213	13	that	that	IN
cord-295559-yc8q62z8	213	14	it	-PRON-	PRP
cord-295559-yc8q62z8	213	15	is	be	VBZ
cord-295559-yc8q62z8	213	16	not	not	RB
cord-295559-yc8q62z8	213	17	due	due	JJ
cord-295559-yc8q62z8	213	18	to	to	IN
cord-295559-yc8q62z8	213	19	MERS	MERS	NNP
cord-295559-yc8q62z8	213	20	-	-	HYPH
cord-295559-yc8q62z8	213	21	CoV	CoV	NNP
cord-295559-yc8q62z8	213	22	S	S	NNP
cord-295559-yc8q62z8	213	23	protein	protein	NN
cord-295559-yc8q62z8	213	24	.	.	.
cord-295559-yc8q62z8	214	1	Uncleaved	Uncleaved	NNP
cord-295559-yc8q62z8	214	2	MERS	MERS	NNP
cord-295559-yc8q62z8	214	3	-	-	HYPH
cord-295559-yc8q62z8	214	4	CoV	CoV	NNP
cord-295559-yc8q62z8	214	5	S	S	NNP
cord-295559-yc8q62z8	214	6	protein	protein	NN
cord-295559-yc8q62z8	214	7	,	,	,
cord-295559-yc8q62z8	214	8	200kDa	200kda	CD
cord-295559-yc8q62z8	214	9	,	,	,
cord-295559-yc8q62z8	214	10	on	on	IN
cord-295559-yc8q62z8	214	11	pseudovirions	pseudovirion	NNS
cord-295559-yc8q62z8	214	12	is	be	VBZ
cord-295559-yc8q62z8	214	13	shown	show	VBN
cord-295559-yc8q62z8	214	14	in	in	IN
cord-295559-yc8q62z8	214	15	lane	lane	NN
cord-295559-yc8q62z8	214	16	4	4	CD
cord-295559-yc8q62z8	214	17	,	,	,
cord-295559-yc8q62z8	214	18	and	and	CC
cord-295559-yc8q62z8	214	19	trypsin	trypsin	NN
cord-295559-yc8q62z8	214	20	treatment	treatment	NN
cord-295559-yc8q62z8	214	21	cleaved	cleave	VBD
cord-295559-yc8q62z8	214	22	all	all	DT
cord-295559-yc8q62z8	214	23	of	of	IN
cord-295559-yc8q62z8	214	24	the	the	DT
cord-295559-yc8q62z8	214	25	S	S	NNP
cord-295559-yc8q62z8	214	26	protein	protein	NN
cord-295559-yc8q62z8	214	27	,	,	,
cord-295559-yc8q62z8	214	28	and	and	CC
cord-295559-yc8q62z8	214	29	generated	generate	VBD
cord-295559-yc8q62z8	214	30	a	a	DT
cord-295559-yc8q62z8	214	31	subunit	subunit	NN
cord-295559-yc8q62z8	214	32	of	of	IN
cord-295559-yc8q62z8	214	33	~65kDa	~65kDa	NNP
cord-295559-yc8q62z8	214	34	that	that	WDT
cord-295559-yc8q62z8	214	35	was	be	VBD
cord-295559-yc8q62z8	214	36	recognized	recognize	VBN
cord-295559-yc8q62z8	214	37	by	by	IN
cord-295559-yc8q62z8	214	38	AO4	AO4	NNP
cord-295559-yc8q62z8	214	39	antibody	antibody	NN
cord-295559-yc8q62z8	214	40	(	(	-LRB-
cord-295559-yc8q62z8	214	41	Lanes	Lanes	NNP
cord-295559-yc8q62z8	214	42	5	5	CD
cord-295559-yc8q62z8	214	43	and	and	CC
cord-295559-yc8q62z8	214	44	6	6	CD
cord-295559-yc8q62z8	214	45	)	)	-RRB-
cord-295559-yc8q62z8	214	46	.	.	.
cord-295559-yc8q62z8	215	1	(	(	-LRB-
cord-295559-yc8q62z8	215	2	EPS	EPS	NNP
cord-295559-yc8q62z8	215	3	)	)	-RRB-
cord-295559-yc8q62z8	215	4	Identification	identification	NN
cord-295559-yc8q62z8	215	5	of	of	IN
cord-295559-yc8q62z8	215	6	a	a	DT
cord-295559-yc8q62z8	215	7	novel	novel	JJ
cord-295559-yc8q62z8	215	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	215	9	in	in	IN
cord-295559-yc8q62z8	215	10	patients	patient	NNS
cord-295559-yc8q62z8	215	11	with	with	IN
cord-295559-yc8q62z8	215	12	severe	severe	JJ
cord-295559-yc8q62z8	215	13	acute	acute	JJ
cord-295559-yc8q62z8	215	14	respiratory	respiratory	JJ
cord-295559-yc8q62z8	215	15	syndrome	syndrome	NN
cord-295559-yc8q62z8	216	1	A	a	DT
cord-295559-yc8q62z8	216	2	novel	novel	JJ
cord-295559-yc8q62z8	216	3	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	216	4	associated	associate	VBN
cord-295559-yc8q62z8	216	5	with	with	IN
cord-295559-yc8q62z8	216	6	severe	severe	JJ
cord-295559-yc8q62z8	216	7	acute	acute	JJ
cord-295559-yc8q62z8	216	8	respiratory	respiratory	JJ
cord-295559-yc8q62z8	216	9	syndrome	syndrome	NN
cord-295559-yc8q62z8	216	10	Recombination	recombination	NN
cord-295559-yc8q62z8	216	11	,	,	,
cord-295559-yc8q62z8	216	12	reservoirs	reservoir	NNS
cord-295559-yc8q62z8	216	13	,	,	,
cord-295559-yc8q62z8	216	14	and	and	CC
cord-295559-yc8q62z8	216	15	the	the	DT
cord-295559-yc8q62z8	216	16	modular	modular	JJ
cord-295559-yc8q62z8	216	17	spike	spike	NN
cord-295559-yc8q62z8	216	18	:	:	:
cord-295559-yc8q62z8	216	19	mechanisms	mechanism	NNS
cord-295559-yc8q62z8	216	20	of	of	IN
cord-295559-yc8q62z8	216	21	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	216	22	cross	cross	JJ
cord-295559-yc8q62z8	216	23	-	-	JJ
cord-295559-yc8q62z8	216	24	species	species	JJ
cord-295559-yc8q62z8	216	25	transmission	transmission	NN
cord-295559-yc8q62z8	216	26	Evidence	evidence	NN
cord-295559-yc8q62z8	216	27	supporting	support	VBG
cord-295559-yc8q62z8	216	28	a	a	DT
cord-295559-yc8q62z8	216	29	zoonotic	zoonotic	JJ
cord-295559-yc8q62z8	216	30	origin	origin	NN
cord-295559-yc8q62z8	216	31	of	of	IN
cord-295559-yc8q62z8	216	32	human	human	JJ
cord-295559-yc8q62z8	216	33	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	216	34	strain	strain	NN
cord-295559-yc8q62z8	216	35	NL63	NL63	NNP
cord-295559-yc8q62z8	216	36	Severe	severe	JJ
cord-295559-yc8q62z8	216	37	acute	acute	JJ
cord-295559-yc8q62z8	216	38	respiratory	respiratory	JJ
cord-295559-yc8q62z8	216	39	syndrome	syndrome	NN
cord-295559-yc8q62z8	216	40	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	216	41	-	-	HYPH
cord-295559-yc8q62z8	216	42	like	like	JJ
cord-295559-yc8q62z8	216	43	virus	virus	NN
cord-295559-yc8q62z8	216	44	in	in	IN
cord-295559-yc8q62z8	216	45	Chinese	chinese	JJ
cord-295559-yc8q62z8	216	46	horseshoe	horseshoe	NN
cord-295559-yc8q62z8	216	47	bats	bat	NNS
cord-295559-yc8q62z8	217	1	Bats	bat	NNS
cord-295559-yc8q62z8	217	2	are	be	VBP
cord-295559-yc8q62z8	217	3	natural	natural	JJ
cord-295559-yc8q62z8	217	4	reservoirs	reservoir	NNS
cord-295559-yc8q62z8	217	5	of	of	IN
cord-295559-yc8q62z8	217	6	SARS	SARS	NNP
cord-295559-yc8q62z8	217	7	-	-	HYPH
cord-295559-yc8q62z8	217	8	like	like	JJ
cord-295559-yc8q62z8	217	9	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	218	1	Distant	distant	JJ
cord-295559-yc8q62z8	218	2	relatives	relative	NNS
cord-295559-yc8q62z8	218	3	of	of	IN
cord-295559-yc8q62z8	218	4	severe	severe	JJ
cord-295559-yc8q62z8	218	5	acute	acute	JJ
cord-295559-yc8q62z8	218	6	respiratory	respiratory	JJ
cord-295559-yc8q62z8	218	7	syndrome	syndrome	NN
cord-295559-yc8q62z8	218	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	218	9	and	and	CC
cord-295559-yc8q62z8	218	10	close	close	JJ
cord-295559-yc8q62z8	218	11	relatives	relative	NNS
cord-295559-yc8q62z8	218	12	of	of	IN
cord-295559-yc8q62z8	218	13	human	human	JJ
cord-295559-yc8q62z8	218	14	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	218	15	229E	229e	CD
cord-295559-yc8q62z8	218	16	in	in	IN
cord-295559-yc8q62z8	218	17	bats	bat	NNS
cord-295559-yc8q62z8	218	18	Complete	complete	VBP
cord-295559-yc8q62z8	218	19	genomic	genomic	JJ
cord-295559-yc8q62z8	218	20	sequence	sequence	NN
cord-295559-yc8q62z8	218	21	of	of	IN
cord-295559-yc8q62z8	218	22	human	human	JJ
cord-295559-yc8q62z8	218	23	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	218	24	OC43	OC43	NNP
cord-295559-yc8q62z8	218	25	:	:	:
cord-295559-yc8q62z8	218	26	molecular	molecular	JJ
cord-295559-yc8q62z8	218	27	clock	clock	NN
cord-295559-yc8q62z8	218	28	analysis	analysis	NN
cord-295559-yc8q62z8	218	29	suggests	suggest	VBZ
cord-295559-yc8q62z8	218	30	a	a	DT
cord-295559-yc8q62z8	218	31	relatively	relatively	RB
cord-295559-yc8q62z8	218	32	recent	recent	JJ
cord-295559-yc8q62z8	218	33	zoonotic	zoonotic	JJ
cord-295559-yc8q62z8	218	34	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	218	35	transmission	transmission	NN
cord-295559-yc8q62z8	218	36	event	event	NN
cord-295559-yc8q62z8	219	1	Middle	Middle	NNP
cord-295559-yc8q62z8	219	2	East	East	NNP
cord-295559-yc8q62z8	219	3	respiratory	respiratory	JJ
cord-295559-yc8q62z8	219	4	syndrome	syndrome	NN
cord-295559-yc8q62z8	219	5	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	219	6	(	(	-LRB-
cord-295559-yc8q62z8	219	7	MERS	MERS	NNP
cord-295559-yc8q62z8	219	8	-	-	HYPH
cord-295559-yc8q62z8	219	9	CoV	CoV	NNP
cord-295559-yc8q62z8	219	10	)	)	-RRB-
cord-295559-yc8q62z8	219	11	Isolation	isolation	NN
cord-295559-yc8q62z8	219	12	of	of	IN
cord-295559-yc8q62z8	219	13	a	a	DT
cord-295559-yc8q62z8	219	14	novel	novel	JJ
cord-295559-yc8q62z8	219	15	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	219	16	from	from	IN
cord-295559-yc8q62z8	219	17	a	a	DT
cord-295559-yc8q62z8	219	18	man	man	NN
cord-295559-yc8q62z8	219	19	with	with	IN
cord-295559-yc8q62z8	219	20	pneumonia	pneumonia	NN
cord-295559-yc8q62z8	219	21	in	in	IN
cord-295559-yc8q62z8	219	22	Saudi	Saudi	NNP
cord-295559-yc8q62z8	219	23	Arabia	Arabia	NNP
cord-295559-yc8q62z8	219	24	Comparative	Comparative	NNP
cord-295559-yc8q62z8	219	25	analysis	analysis	NN
cord-295559-yc8q62z8	219	26	of	of	IN
cord-295559-yc8q62z8	219	27	twelve	twelve	CD
cord-295559-yc8q62z8	219	28	genomes	genome	NNS
cord-295559-yc8q62z8	219	29	of	of	IN
cord-295559-yc8q62z8	219	30	three	three	CD
cord-295559-yc8q62z8	219	31	novel	novel	NN
cord-295559-yc8q62z8	219	32	group	group	NN
cord-295559-yc8q62z8	219	33	2c	2c	NNP
cord-295559-yc8q62z8	219	34	and	and	CC
cord-295559-yc8q62z8	219	35	group	group	NN
cord-295559-yc8q62z8	219	36	2d	2d	NNP
cord-295559-yc8q62z8	219	37	coronaviruses	coronaviruses	NNP
cord-295559-yc8q62z8	219	38	reveals	reveal	VBZ
cord-295559-yc8q62z8	219	39	unique	unique	JJ
cord-295559-yc8q62z8	219	40	group	group	NN
cord-295559-yc8q62z8	219	41	and	and	CC
cord-295559-yc8q62z8	219	42	subgroup	subgroup	NN
cord-295559-yc8q62z8	219	43	features	feature	VBZ
cord-295559-yc8q62z8	219	44	Genomic	genomic	JJ
cord-295559-yc8q62z8	219	45	characterization	characterization	NN
cord-295559-yc8q62z8	219	46	of	of	IN
cord-295559-yc8q62z8	219	47	a	a	DT
cord-295559-yc8q62z8	219	48	newly	newly	RB
cord-295559-yc8q62z8	219	49	discovered	discover	VBN
cord-295559-yc8q62z8	219	50	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	219	51	associated	associate	VBN
cord-295559-yc8q62z8	219	52	with	with	IN
cord-295559-yc8q62z8	219	53	acute	acute	JJ
cord-295559-yc8q62z8	219	54	respiratory	respiratory	JJ
cord-295559-yc8q62z8	219	55	distress	distress	NN
cord-295559-yc8q62z8	219	56	syndrome	syndrome	NN
cord-295559-yc8q62z8	219	57	in	in	IN
cord-295559-yc8q62z8	219	58	humans	human	NNS
cord-295559-yc8q62z8	219	59	Coronaviruses	Coronaviruses	NNPS
cord-295559-yc8q62z8	219	60	in	in	IN
cord-295559-yc8q62z8	219	61	bats	bat	NNS
cord-295559-yc8q62z8	219	62	from	from	IN
cord-295559-yc8q62z8	219	63	Mexico	Mexico	NNP
cord-295559-yc8q62z8	219	64	Human	Human	NNP
cord-295559-yc8q62z8	219	65	Betacoronavirus	Betacoronavirus	NNP
cord-295559-yc8q62z8	219	66	2c	2c	NN
cord-295559-yc8q62z8	219	67	EMC/2012-related	emc/2012-relate	VBD
cord-295559-yc8q62z8	219	68	Viruses	Viruses	NNPS
cord-295559-yc8q62z8	219	69	in	in	IN
cord-295559-yc8q62z8	219	70	Bats	Bats	NNPS
cord-295559-yc8q62z8	219	71	,	,	,
cord-295559-yc8q62z8	219	72	Ghana	Ghana	NNP
cord-295559-yc8q62z8	219	73	and	and	CC
cord-295559-yc8q62z8	219	74	Europe	Europe	NNP
cord-295559-yc8q62z8	219	75	Genomic	Genomic	NNP
cord-295559-yc8q62z8	219	76	characterization	characterization	NN
cord-295559-yc8q62z8	219	77	of	of	IN
cord-295559-yc8q62z8	219	78	a	a	DT
cord-295559-yc8q62z8	219	79	newly	newly	RB
cord-295559-yc8q62z8	219	80	discovered	discover	VBN
cord-295559-yc8q62z8	219	81	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	219	82	associated	associate	VBN
cord-295559-yc8q62z8	219	83	with	with	IN
cord-295559-yc8q62z8	219	84	acute	acute	JJ
cord-295559-yc8q62z8	219	85	respiratory	respiratory	JJ
cord-295559-yc8q62z8	219	86	distress	distress	NN
cord-295559-yc8q62z8	219	87	syndrome	syndrome	NN
cord-295559-yc8q62z8	219	88	in	in	IN
cord-295559-yc8q62z8	219	89	humans	human	NNS
cord-295559-yc8q62z8	220	1	The	the	DT
cord-295559-yc8q62z8	220	2	new	new	JJ
cord-295559-yc8q62z8	220	3	age	age	NN
cord-295559-yc8q62z8	220	4	of	of	IN
cord-295559-yc8q62z8	220	5	virus	virus	NN
cord-295559-yc8q62z8	220	6	discovery	discovery	NN
cord-295559-yc8q62z8	220	7	:	:	:
cord-295559-yc8q62z8	220	8	genomic	genomic	JJ
cord-295559-yc8q62z8	220	9	analysis	analysis	NN
cord-295559-yc8q62z8	220	10	of	of	IN
cord-295559-yc8q62z8	220	11	a	a	DT
cord-295559-yc8q62z8	220	12	novel	novel	JJ
cord-295559-yc8q62z8	220	13	human	human	JJ
cord-295559-yc8q62z8	220	14	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	220	15	isolated	isolate	VBN
cord-295559-yc8q62z8	220	16	from	from	IN
cord-295559-yc8q62z8	220	17	a	a	DT
cord-295559-yc8q62z8	220	18	fatal	fatal	JJ
cord-295559-yc8q62z8	220	19	case	case	NN
cord-295559-yc8q62z8	220	20	of	of	IN
cord-295559-yc8q62z8	220	21	pneumonia	pneumonia	NN
cord-295559-yc8q62z8	220	22	Structures	structure	NNS
cord-295559-yc8q62z8	220	23	and	and	CC
cord-295559-yc8q62z8	220	24	mechanisms	mechanism	NNS
cord-295559-yc8q62z8	220	25	of	of	IN
cord-295559-yc8q62z8	220	26	viral	viral	JJ
cord-295559-yc8q62z8	220	27	membrane	membrane	NN
cord-295559-yc8q62z8	220	28	fusion	fusion	NN
cord-295559-yc8q62z8	220	29	proteins	protein	NNS
cord-295559-yc8q62z8	220	30	:	:	:
cord-295559-yc8q62z8	221	1	multiple	multiple	JJ
cord-295559-yc8q62z8	221	2	variations	variation	NNS
cord-295559-yc8q62z8	221	3	on	on	IN
cord-295559-yc8q62z8	221	4	a	a	DT
cord-295559-yc8q62z8	221	5	common	common	JJ
cord-295559-yc8q62z8	221	6	theme	theme	NN
cord-295559-yc8q62z8	221	7	Proteolytic	Proteolytic	NNP
cord-295559-yc8q62z8	221	8	cleavage	cleavage	NN
cord-295559-yc8q62z8	221	9	of	of	IN
cord-295559-yc8q62z8	221	10	the	the	DT
cord-295559-yc8q62z8	221	11	E2	E2	NNP
cord-295559-yc8q62z8	221	12	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	221	13	of	of	IN
cord-295559-yc8q62z8	221	14	murine	murine	JJ
cord-295559-yc8q62z8	221	15	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	221	16	:	:	:
cord-295559-yc8q62z8	221	17	host	host	NN
cord-295559-yc8q62z8	221	18	-	-	HYPH
cord-295559-yc8q62z8	221	19	dependent	dependent	JJ
cord-295559-yc8q62z8	221	20	differences	difference	NNS
cord-295559-yc8q62z8	221	21	in	in	IN
cord-295559-yc8q62z8	221	22	proteolytic	proteolytic	JJ
cord-295559-yc8q62z8	221	23	cleavage	cleavage	NN
cord-295559-yc8q62z8	221	24	and	and	CC
cord-295559-yc8q62z8	221	25	cell	cell	NN
cord-295559-yc8q62z8	221	26	fusion	fusion	NN
cord-295559-yc8q62z8	221	27	Evidence	evidence	NN
cord-295559-yc8q62z8	221	28	that	that	IN
cord-295559-yc8q62z8	221	29	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	221	30	activates	activate	VBZ
cord-295559-yc8q62z8	221	31	the	the	DT
cord-295559-yc8q62z8	221	32	severe	severe	JJ
cord-295559-yc8q62z8	221	33	acute	acute	JJ
cord-295559-yc8q62z8	221	34	respiratory	respiratory	JJ
cord-295559-yc8q62z8	221	35	syndrome	syndrome	NN
cord-295559-yc8q62z8	221	36	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	221	37	spike	spike	NN
cord-295559-yc8q62z8	221	38	protein	protein	NN
cord-295559-yc8q62z8	221	39	for	for	IN
cord-295559-yc8q62z8	221	40	membrane	membrane	NN
cord-295559-yc8q62z8	221	41	fusion	fusion	NN
cord-295559-yc8q62z8	221	42	and	and	CC
cord-295559-yc8q62z8	221	43	reduces	reduce	VBZ
cord-295559-yc8q62z8	221	44	viral	viral	JJ
cord-295559-yc8q62z8	221	45	control	control	NN
cord-295559-yc8q62z8	221	46	by	by	IN
cord-295559-yc8q62z8	221	47	the	the	DT
cord-295559-yc8q62z8	221	48	humoral	humoral	JJ
cord-295559-yc8q62z8	221	49	immune	immune	JJ
cord-295559-yc8q62z8	221	50	response	response	NN
cord-295559-yc8q62z8	221	51	Efficient	efficient	JJ
cord-295559-yc8q62z8	221	52	activation	activation	NN
cord-295559-yc8q62z8	221	53	of	of	IN
cord-295559-yc8q62z8	221	54	the	the	DT
cord-295559-yc8q62z8	221	55	severe	severe	JJ
cord-295559-yc8q62z8	221	56	acute	acute	JJ
cord-295559-yc8q62z8	221	57	respiratory	respiratory	JJ
cord-295559-yc8q62z8	221	58	syndrome	syndrome	NN
cord-295559-yc8q62z8	221	59	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	221	60	spike	spike	NN
cord-295559-yc8q62z8	221	61	protein	protein	NN
cord-295559-yc8q62z8	221	62	by	by	IN
cord-295559-yc8q62z8	221	63	the	the	DT
cord-295559-yc8q62z8	221	64	transmembrane	transmembrane	NNP
cord-295559-yc8q62z8	221	65	protease	protease	NN
cord-295559-yc8q62z8	221	66	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	221	67	Protease	Protease	NNP
cord-295559-yc8q62z8	221	68	-	-	HYPH
cord-295559-yc8q62z8	221	69	mediated	mediate	VBN
cord-295559-yc8q62z8	221	70	enhancement	enhancement	NN
cord-295559-yc8q62z8	221	71	of	of	IN
cord-295559-yc8q62z8	221	72	severe	severe	JJ
cord-295559-yc8q62z8	221	73	acute	acute	JJ
cord-295559-yc8q62z8	221	74	respiratory	respiratory	JJ
cord-295559-yc8q62z8	221	75	syndrome	syndrome	NN
cord-295559-yc8q62z8	221	76	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	221	77	infection	infection	NN
cord-295559-yc8q62z8	221	78	Inhibitors	Inhibitors	NNP
cord-295559-yc8q62z8	221	79	of	of	IN
cord-295559-yc8q62z8	221	80	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	222	1	L	l	NN
cord-295559-yc8q62z8	222	2	prevent	prevent	VBP
cord-295559-yc8q62z8	222	3	severe	severe	JJ
cord-295559-yc8q62z8	222	4	acute	acute	JJ
cord-295559-yc8q62z8	222	5	respiratory	respiratory	JJ
cord-295559-yc8q62z8	222	6	syndrome	syndrome	NN
cord-295559-yc8q62z8	222	7	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	222	8	entry	entry	NN
cord-295559-yc8q62z8	222	9	Cloning	clone	VBG
cord-295559-yc8q62z8	222	10	of	of	IN
cord-295559-yc8q62z8	222	11	the	the	DT
cord-295559-yc8q62z8	222	12	mouse	mouse	NN
cord-295559-yc8q62z8	222	13	hepatitis	hepatitis	NN
cord-295559-yc8q62z8	222	14	virus	virus	NN
cord-295559-yc8q62z8	222	15	(	(	-LRB-
cord-295559-yc8q62z8	222	16	MHV	mhv	NN
cord-295559-yc8q62z8	222	17	)	)	-RRB-
cord-295559-yc8q62z8	222	18	receptor	receptor	NN
cord-295559-yc8q62z8	222	19	:	:	:
cord-295559-yc8q62z8	222	20	expression	expression	NN
cord-295559-yc8q62z8	222	21	in	in	IN
cord-295559-yc8q62z8	222	22	human	human	JJ
cord-295559-yc8q62z8	222	23	and	and	CC
cord-295559-yc8q62z8	222	24	hamster	hamster	NN
cord-295559-yc8q62z8	222	25	cell	cell	NN
cord-295559-yc8q62z8	222	26	lines	line	NNS
cord-295559-yc8q62z8	222	27	confers	confer	VBZ
cord-295559-yc8q62z8	222	28	susceptibility	susceptibility	NN
cord-295559-yc8q62z8	222	29	to	to	IN
cord-295559-yc8q62z8	223	1	MHV	MHV	NNP
cord-295559-yc8q62z8	223	2	Aminopeptidase	Aminopeptidase	NNP
cord-295559-yc8q62z8	223	3	N	N	NNP
cord-295559-yc8q62z8	223	4	is	be	VBZ
cord-295559-yc8q62z8	223	5	a	a	DT
cord-295559-yc8q62z8	223	6	major	major	JJ
cord-295559-yc8q62z8	223	7	receptor	receptor	NN
cord-295559-yc8q62z8	223	8	for	for	IN
cord-295559-yc8q62z8	223	9	the	the	DT
cord-295559-yc8q62z8	223	10	entero	entero	NNP
cord-295559-yc8q62z8	223	11	-	-	HYPH
cord-295559-yc8q62z8	223	12	pathogenic	pathogenic	JJ
cord-295559-yc8q62z8	223	13	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	223	14	TGEV	tgev	ADD
cord-295559-yc8q62z8	223	15	Feline	feline	JJ
cord-295559-yc8q62z8	223	16	aminopeptidase	aminopeptidase	NN
cord-295559-yc8q62z8	223	17	N	n	CD
cord-295559-yc8q62z8	223	18	serves	serve	VBZ
cord-295559-yc8q62z8	223	19	as	as	IN
cord-295559-yc8q62z8	223	20	a	a	DT
cord-295559-yc8q62z8	223	21	receptor	receptor	NN
cord-295559-yc8q62z8	223	22	for	for	IN
cord-295559-yc8q62z8	223	23	feline	feline	JJ
cord-295559-yc8q62z8	223	24	,	,	,
cord-295559-yc8q62z8	223	25	canine	canine	JJ
cord-295559-yc8q62z8	223	26	,	,	,
cord-295559-yc8q62z8	223	27	porcine	porcine	JJ
cord-295559-yc8q62z8	223	28	,	,	,
cord-295559-yc8q62z8	223	29	and	and	CC
cord-295559-yc8q62z8	223	30	human	human	JJ
cord-295559-yc8q62z8	223	31	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	223	32	in	in	IN
cord-295559-yc8q62z8	223	33	serogroup	serogroup	NNP
cord-295559-yc8q62z8	224	1	I	-PRON-	PRP
cord-295559-yc8q62z8	224	2	Human	Human	NNP
cord-295559-yc8q62z8	224	3	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	225	1	NL63	NL63	NNP
cord-295559-yc8q62z8	225	2	employs	employ	VBZ
cord-295559-yc8q62z8	225	3	the	the	DT
cord-295559-yc8q62z8	225	4	severe	severe	JJ
cord-295559-yc8q62z8	225	5	acute	acute	JJ
cord-295559-yc8q62z8	225	6	respiratory	respiratory	JJ
cord-295559-yc8q62z8	225	7	syndrome	syndrome	NN
cord-295559-yc8q62z8	225	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	225	9	receptor	receptor	NN
cord-295559-yc8q62z8	225	10	for	for	IN
cord-295559-yc8q62z8	225	11	cellular	cellular	JJ
cord-295559-yc8q62z8	225	12	entry	entry	NN
cord-295559-yc8q62z8	226	1	Angiotensinconverting	angiotensinconverting	NN
cord-295559-yc8q62z8	226	2	enzyme	enzyme	NN
cord-295559-yc8q62z8	226	3	2	2	CD
cord-295559-yc8q62z8	226	4	is	be	VBZ
cord-295559-yc8q62z8	226	5	a	a	DT
cord-295559-yc8q62z8	226	6	functional	functional	JJ
cord-295559-yc8q62z8	226	7	receptor	receptor	NN
cord-295559-yc8q62z8	226	8	for	for	IN
cord-295559-yc8q62z8	226	9	the	the	DT
cord-295559-yc8q62z8	226	10	SARS	SARS	NNP
cord-295559-yc8q62z8	226	11	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	226	12	Dipeptidyl	Dipeptidyl	NNP
cord-295559-yc8q62z8	226	13	peptidase	peptidase	NN
cord-295559-yc8q62z8	226	14	4	4	CD
cord-295559-yc8q62z8	226	15	is	be	VBZ
cord-295559-yc8q62z8	226	16	a	a	DT
cord-295559-yc8q62z8	226	17	functional	functional	JJ
cord-295559-yc8q62z8	226	18	receptor	receptor	NN
cord-295559-yc8q62z8	226	19	for	for	IN
cord-295559-yc8q62z8	226	20	the	the	DT
cord-295559-yc8q62z8	226	21	emerging	emerge	VBG
cord-295559-yc8q62z8	226	22	human	human	JJ
cord-295559-yc8q62z8	226	23	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	226	24	-	-	HYPH
cord-295559-yc8q62z8	226	25	EMC	EMC	NNP
cord-295559-yc8q62z8	226	26	Crystal	Crystal	NNP
cord-295559-yc8q62z8	226	27	structure	structure	NN
cord-295559-yc8q62z8	226	28	of	of	IN
cord-295559-yc8q62z8	226	29	bovine	bovine	JJ
cord-295559-yc8q62z8	226	30	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	226	31	spike	spike	NN
cord-295559-yc8q62z8	226	32	protein	protein	NN
cord-295559-yc8q62z8	226	33	lectin	lectin	NN
cord-295559-yc8q62z8	226	34	domain	domain	NN
cord-295559-yc8q62z8	226	35	Retroviral	retroviral	NN
cord-295559-yc8q62z8	226	36	vectors	vector	NNS
cord-295559-yc8q62z8	226	37	pseudotyped	pseudotyped	NNS
cord-295559-yc8q62z8	226	38	with	with	IN
cord-295559-yc8q62z8	226	39	severe	severe	JJ
cord-295559-yc8q62z8	226	40	acute	acute	JJ
cord-295559-yc8q62z8	226	41	respiratory	respiratory	JJ
cord-295559-yc8q62z8	226	42	syndrome	syndrome	NN
cord-295559-yc8q62z8	226	43	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	226	44	S	S	NNP
cord-295559-yc8q62z8	226	45	protein	protein	NN
cord-295559-yc8q62z8	226	46	Aromatic	aromatic	JJ
cord-295559-yc8q62z8	226	47	amino	amino	NN
cord-295559-yc8q62z8	226	48	acids	acid	NNS
cord-295559-yc8q62z8	226	49	in	in	IN
cord-295559-yc8q62z8	226	50	the	the	DT
cord-295559-yc8q62z8	226	51	juxtamembrane	juxtamembrane	NNP
cord-295559-yc8q62z8	226	52	domain	domain	NN
cord-295559-yc8q62z8	226	53	of	of	IN
cord-295559-yc8q62z8	226	54	severe	severe	JJ
cord-295559-yc8q62z8	226	55	acute	acute	JJ
cord-295559-yc8q62z8	226	56	respiratory	respiratory	JJ
cord-295559-yc8q62z8	226	57	syndrome	syndrome	NN
cord-295559-yc8q62z8	226	58	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	226	59	spike	spike	NN
cord-295559-yc8q62z8	226	60	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	226	61	are	be	VBP
cord-295559-yc8q62z8	226	62	important	important	JJ
cord-295559-yc8q62z8	226	63	for	for	IN
cord-295559-yc8q62z8	226	64	receptor	receptor	NN
cord-295559-yc8q62z8	226	65	-	-	HYPH
cord-295559-yc8q62z8	226	66	dependent	dependent	JJ
cord-295559-yc8q62z8	226	67	virus	virus	NN
cord-295559-yc8q62z8	226	68	entry	entry	NN
cord-295559-yc8q62z8	226	69	and	and	CC
cord-295559-yc8q62z8	226	70	cell	cell	NN
cord-295559-yc8q62z8	226	71	-	-	HYPH
cord-295559-yc8q62z8	226	72	cell	cell	NN
cord-295559-yc8q62z8	226	73	fusion	fusion	NN
cord-295559-yc8q62z8	227	1	Intracellular	Intracellular	NNP
cord-295559-yc8q62z8	227	2	targeting	target	VBG
cord-295559-yc8q62z8	227	3	signals	signal	NNS
cord-295559-yc8q62z8	227	4	contribute	contribute	VBP
cord-295559-yc8q62z8	227	5	to	to	IN
cord-295559-yc8q62z8	227	6	localization	localization	NN
cord-295559-yc8q62z8	227	7	of	of	IN
cord-295559-yc8q62z8	227	8	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	227	9	spike	spike	NN
cord-295559-yc8q62z8	227	10	proteins	protein	NNS
cord-295559-yc8q62z8	227	11	near	near	IN
cord-295559-yc8q62z8	227	12	the	the	DT
cord-295559-yc8q62z8	227	13	virus	virus	NN
cord-295559-yc8q62z8	227	14	assembly	assembly	NN
cord-295559-yc8q62z8	227	15	site	site	NN
cord-295559-yc8q62z8	228	1	The	the	DT
cord-295559-yc8q62z8	228	2	Spike	Spike	NNP
cord-295559-yc8q62z8	228	3	Protein	Protein	NNP
cord-295559-yc8q62z8	228	4	of	of	IN
cord-295559-yc8q62z8	228	5	the	the	DT
cord-295559-yc8q62z8	228	6	Emerging	Emerging	NNP
cord-295559-yc8q62z8	228	7	Betacoronavirus	Betacoronavirus	NNP
cord-295559-yc8q62z8	228	8	EMC	EMC	NNP
cord-295559-yc8q62z8	228	9	Uses	use	VBZ
cord-295559-yc8q62z8	228	10	a	a	DT
cord-295559-yc8q62z8	228	11	Novel	Novel	NNP
cord-295559-yc8q62z8	228	12	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	228	13	Receptor	Receptor	NNP
cord-295559-yc8q62z8	228	14	for	for	IN
cord-295559-yc8q62z8	228	15	Entry	Entry	NNP
cord-295559-yc8q62z8	228	16	,	,	,
cord-295559-yc8q62z8	228	17	Can	Can	MD
cord-295559-yc8q62z8	228	18	Be	be	VB
cord-295559-yc8q62z8	228	19	Activated	activate	VBN
cord-295559-yc8q62z8	228	20	by	by	IN
cord-295559-yc8q62z8	228	21	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	228	22	,	,	,
cord-295559-yc8q62z8	228	23	and	and	CC
cord-295559-yc8q62z8	228	24	Is	be	VBZ
cord-295559-yc8q62z8	228	25	Targeted	target	VBN
cord-295559-yc8q62z8	228	26	by	by	IN
cord-295559-yc8q62z8	228	27	Neutralizing	neutralize	VBG
cord-295559-yc8q62z8	228	28	Antibodies	Antibodies	NNP
cord-295559-yc8q62z8	228	29	Human	Human	NNP
cord-295559-yc8q62z8	228	30	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	228	31	EMC	EMC	NNP
cord-295559-yc8q62z8	229	1	Does	do	VBZ
cord-295559-yc8q62z8	229	2	Not	not	RB
cord-295559-yc8q62z8	229	3	Require	require	VB
cord-295559-yc8q62z8	229	4	the	the	DT
cord-295559-yc8q62z8	229	5	SARS	SARS	NNP
cord-295559-yc8q62z8	229	6	-	-	HYPH
cord-295559-yc8q62z8	229	7	Coronavirus	Coronavirus	NNP
cord-295559-yc8q62z8	229	8	Receptor	Receptor	NNP
cord-295559-yc8q62z8	229	9	and	and	CC
cord-295559-yc8q62z8	229	10	Maintains	maintain	VBZ
cord-295559-yc8q62z8	229	11	Broad	Broad	NNP
cord-295559-yc8q62z8	229	12	Replicative	Replicative	NNP
cord-295559-yc8q62z8	229	13	Capability	Capability	NNP
cord-295559-yc8q62z8	229	14	in	in	IN
cord-295559-yc8q62z8	229	15	Mammalian	Mammalian	NNP
cord-295559-yc8q62z8	229	16	Cell	Cell	NNP
cord-295559-yc8q62z8	229	17	Lines	line	NNS
cord-295559-yc8q62z8	229	18	Differential	Differential	NNP
cord-295559-yc8q62z8	229	19	Cell	cell	NN
cord-295559-yc8q62z8	229	20	Line	line	NN
cord-295559-yc8q62z8	229	21	Susceptibility	susceptibility	NN
cord-295559-yc8q62z8	229	22	to	to	IN
cord-295559-yc8q62z8	229	23	the	the	DT
cord-295559-yc8q62z8	229	24	Emerging	Emerging	NNP
cord-295559-yc8q62z8	229	25	Novel	Novel	NNP
cord-295559-yc8q62z8	229	26	Human	Human	NNP
cord-295559-yc8q62z8	229	27	Betacoronavirus	Betacoronavirus	NNP
cord-295559-yc8q62z8	229	28	2c	2c	NN
cord-295559-yc8q62z8	229	29	EMC/2012	EMC/2012	NNP
cord-295559-yc8q62z8	229	30	:	:	:
cord-295559-yc8q62z8	230	1	Implications	implication	NNS
cord-295559-yc8q62z8	230	2	for	for	IN
cord-295559-yc8q62z8	230	3	Disease	Disease	NNP
cord-295559-yc8q62z8	230	4	Pathogenesis	Pathogenesis	NNP
cord-295559-yc8q62z8	230	5	and	and	CC
cord-295559-yc8q62z8	230	6	Clinical	Clinical	NNP
cord-295559-yc8q62z8	230	7	Manifestation	manifestation	NN
cord-295559-yc8q62z8	231	1	LSECtin	lsectin	UH
cord-295559-yc8q62z8	231	2	interacts	interact	VBZ
cord-295559-yc8q62z8	231	3	with	with	IN
cord-295559-yc8q62z8	231	4	filovirus	filovirus	NN
cord-295559-yc8q62z8	231	5	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	231	6	and	and	CC
cord-295559-yc8q62z8	231	7	the	the	DT
cord-295559-yc8q62z8	231	8	spike	spike	NN
cord-295559-yc8q62z8	231	9	protein	protein	NN
cord-295559-yc8q62z8	231	10	of	of	IN
cord-295559-yc8q62z8	231	11	SARS	SARS	NNP
cord-295559-yc8q62z8	231	12	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	231	13	CD209L	CD209L	NNP
cord-295559-yc8q62z8	231	14	(	(	-LRB-
cord-295559-yc8q62z8	231	15	L	l	NN
cord-295559-yc8q62z8	231	16	-	-	HYPH
cord-295559-yc8q62z8	231	17	SIGN	SIGN	NNP
cord-295559-yc8q62z8	231	18	)	)	-RRB-
cord-295559-yc8q62z8	231	19	is	be	VBZ
cord-295559-yc8q62z8	231	20	a	a	DT
cord-295559-yc8q62z8	231	21	receptor	receptor	NN
cord-295559-yc8q62z8	231	22	for	for	IN
cord-295559-yc8q62z8	231	23	severe	severe	JJ
cord-295559-yc8q62z8	231	24	acute	acute	JJ
cord-295559-yc8q62z8	231	25	respiratory	respiratory	JJ
cord-295559-yc8q62z8	231	26	syndrome	syndrome	NN
cord-295559-yc8q62z8	231	27	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	231	28	Characterization	characterization	NN
cord-295559-yc8q62z8	231	29	of	of	IN
cord-295559-yc8q62z8	231	30	severe	severe	JJ
cord-295559-yc8q62z8	231	31	acute	acute	JJ
cord-295559-yc8q62z8	231	32	respiratory	respiratory	JJ
cord-295559-yc8q62z8	231	33	syndromeassociated	syndromeassociate	VBN
cord-295559-yc8q62z8	231	34	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	231	35	(	(	-LRB-
cord-295559-yc8q62z8	231	36	SARS	SARS	NNP
cord-295559-yc8q62z8	231	37	-	-	HYPH
cord-295559-yc8q62z8	231	38	CoV	CoV	NNP
cord-295559-yc8q62z8	231	39	)	)	-RRB-
cord-295559-yc8q62z8	232	1	spike	spike	NN
cord-295559-yc8q62z8	232	2	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	232	3	-	-	HYPH
cord-295559-yc8q62z8	232	4	mediated	mediate	VBN
cord-295559-yc8q62z8	232	5	viral	viral	JJ
cord-295559-yc8q62z8	232	6	entry	entry	NN
cord-295559-yc8q62z8	232	7	Cathepsin	Cathepsin	NNP
cord-295559-yc8q62z8	232	8	L	L	NNP
cord-295559-yc8q62z8	232	9	and	and	CC
cord-295559-yc8q62z8	232	10	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	232	11	B	B	NNP
cord-295559-yc8q62z8	232	12	mediate	mediate	VB
cord-295559-yc8q62z8	232	13	reovirus	reovirus	NN
cord-295559-yc8q62z8	232	14	disassembly	disassembly	NN
cord-295559-yc8q62z8	232	15	in	in	IN
cord-295559-yc8q62z8	232	16	murine	murine	JJ
cord-295559-yc8q62z8	232	17	fibroblast	fibroblast	NN
cord-295559-yc8q62z8	232	18	cells	cell	NNS
cord-295559-yc8q62z8	233	1	Endosomal	Endosomal	NNP
cord-295559-yc8q62z8	233	2	proteolysis	proteolysis	NN
cord-295559-yc8q62z8	233	3	of	of	IN
cord-295559-yc8q62z8	233	4	the	the	DT
cord-295559-yc8q62z8	233	5	Ebola	Ebola	NNP
cord-295559-yc8q62z8	233	6	virus	virus	NN
cord-295559-yc8q62z8	233	7	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	233	8	is	be	VBZ
cord-295559-yc8q62z8	233	9	necessary	necessary	JJ
cord-295559-yc8q62z8	233	10	for	for	IN
cord-295559-yc8q62z8	233	11	infection	infection	NN
cord-295559-yc8q62z8	233	12	SARS	SARS	NNP
cord-295559-yc8q62z8	233	13	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	233	14	,	,	,
cord-295559-yc8q62z8	233	15	but	but	CC
cord-295559-yc8q62z8	233	16	not	not	RB
cord-295559-yc8q62z8	233	17	human	human	JJ
cord-295559-yc8q62z8	233	18	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	234	1	NL63	NL63	NNP
cord-295559-yc8q62z8	234	2	,	,	,
cord-295559-yc8q62z8	234	3	utilizes	utilize	VBZ
cord-295559-yc8q62z8	234	4	cathepsin	cathepsin	NN
cord-295559-yc8q62z8	234	5	L	l	NN
cord-295559-yc8q62z8	234	6	to	to	TO
cord-295559-yc8q62z8	234	7	infect	infect	VB
cord-295559-yc8q62z8	234	8	ACE2-expressing	ace2-expressing	NN
cord-295559-yc8q62z8	234	9	cells	cell	NNS
cord-295559-yc8q62z8	234	10	Matriptase	Matriptase	NNP
cord-295559-yc8q62z8	234	11	,	,	,
cord-295559-yc8q62z8	234	12	HAT	hat	NN
cord-295559-yc8q62z8	234	13	,	,	,
cord-295559-yc8q62z8	234	14	and	and	CC
cord-295559-yc8q62z8	234	15	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	235	1	Activate	activate	VB
cord-295559-yc8q62z8	235	2	the	the	DT
cord-295559-yc8q62z8	235	3	Hemagglutinin	Hemagglutinin	NNP
cord-295559-yc8q62z8	235	4	of	of	IN
cord-295559-yc8q62z8	235	5	H9N2	H9N2	NNP
cord-295559-yc8q62z8	236	1	Influenza	Influenza	NNP
cord-295559-yc8q62z8	236	2	A	a	DT
cord-295559-yc8q62z8	236	3	Viruses	virus	NNS
cord-295559-yc8q62z8	237	1	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	238	1	and	and	CC
cord-295559-yc8q62z8	238	2	TMPRSS4	TMPRSS4	NNS
cord-295559-yc8q62z8	238	3	facilitate	facilitate	VBP
cord-295559-yc8q62z8	238	4	trypsin	trypsin	NN
cord-295559-yc8q62z8	238	5	-	-	HYPH
cord-295559-yc8q62z8	238	6	independent	independent	JJ
cord-295559-yc8q62z8	238	7	spread	spread	NN
cord-295559-yc8q62z8	238	8	of	of	IN
cord-295559-yc8q62z8	238	9	influenza	influenza	NN
cord-295559-yc8q62z8	238	10	virus	virus	NN
cord-295559-yc8q62z8	238	11	in	in	IN
cord-295559-yc8q62z8	238	12	Caco-2	Caco-2	NNP
cord-295559-yc8q62z8	238	13	cells	cell	NNS
cord-295559-yc8q62z8	238	14	Proteolytic	proteolytic	JJ
cord-295559-yc8q62z8	238	15	activation	activation	NN
cord-295559-yc8q62z8	238	16	of	of	IN
cord-295559-yc8q62z8	238	17	influenza	influenza	NN
cord-295559-yc8q62z8	238	18	viruses	virus	NNS
cord-295559-yc8q62z8	238	19	by	by	IN
cord-295559-yc8q62z8	238	20	serine	serine	NN
cord-295559-yc8q62z8	238	21	proteases	protease	NNS
cord-295559-yc8q62z8	238	22	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	238	23	and	and	CC
cord-295559-yc8q62z8	238	24	HAT	HAT	NNP
cord-295559-yc8q62z8	238	25	from	from	IN
cord-295559-yc8q62z8	238	26	human	human	JJ
cord-295559-yc8q62z8	238	27	airway	airway	NN
cord-295559-yc8q62z8	238	28	epithelium	epithelium	NN
cord-295559-yc8q62z8	238	29	Efficient	efficient	JJ
cord-295559-yc8q62z8	238	30	multiplication	multiplication	NN
cord-295559-yc8q62z8	238	31	of	of	IN
cord-295559-yc8q62z8	238	32	human	human	JJ
cord-295559-yc8q62z8	238	33	metapneumovirus	metapneumovirus	NN
cord-295559-yc8q62z8	238	34	in	in	IN
cord-295559-yc8q62z8	238	35	Vero	Vero	NNP
cord-295559-yc8q62z8	238	36	cells	cell	NNS
cord-295559-yc8q62z8	238	37	expressing	express	VBG
cord-295559-yc8q62z8	238	38	the	the	DT
cord-295559-yc8q62z8	238	39	transmembrane	transmembrane	NN
cord-295559-yc8q62z8	238	40	serine	serine	NN
cord-295559-yc8q62z8	238	41	protease	protease	NN
cord-295559-yc8q62z8	238	42	TMPRSS2	TMPRSS2	NNP
cord-295559-yc8q62z8	238	43	Tropism	tropism	NN
cord-295559-yc8q62z8	238	44	and	and	CC
cord-295559-yc8q62z8	238	45	innate	innate	JJ
cord-295559-yc8q62z8	238	46	immune	immune	JJ
cord-295559-yc8q62z8	238	47	responses	response	NNS
cord-295559-yc8q62z8	238	48	of	of	IN
cord-295559-yc8q62z8	238	49	the	the	DT
cord-295559-yc8q62z8	238	50	novel	novel	JJ
cord-295559-yc8q62z8	238	51	human	human	JJ
cord-295559-yc8q62z8	238	52	betacoronavirus	betacoronavirus	NN
cord-295559-yc8q62z8	238	53	lineage	lineage	NN
cord-295559-yc8q62z8	238	54	C	C	NNP
cord-295559-yc8q62z8	238	55	virus	virus	NN
cord-295559-yc8q62z8	238	56	in	in	IN
cord-295559-yc8q62z8	238	57	human	human	JJ
cord-295559-yc8q62z8	238	58	ex	ex	FW
cord-295559-yc8q62z8	238	59	vivo	vivo	NN
cord-295559-yc8q62z8	238	60	respiratory	respiratory	JJ
cord-295559-yc8q62z8	238	61	organ	organ	NN
cord-295559-yc8q62z8	238	62	cultures	culture	NNS
cord-295559-yc8q62z8	238	63	Efficient	efficient	JJ
cord-295559-yc8q62z8	238	64	replication	replication	NN
cord-295559-yc8q62z8	238	65	of	of	IN
cord-295559-yc8q62z8	238	66	the	the	DT
cord-295559-yc8q62z8	238	67	novel	novel	JJ
cord-295559-yc8q62z8	238	68	human	human	JJ
cord-295559-yc8q62z8	238	69	betacoronavirus	betacoronavirus	NNP
cord-295559-yc8q62z8	238	70	EMC	EMC	NNP
cord-295559-yc8q62z8	238	71	on	on	IN
cord-295559-yc8q62z8	238	72	primary	primary	JJ
cord-295559-yc8q62z8	238	73	human	human	JJ
cord-295559-yc8q62z8	238	74	epithelium	epithelium	NN
cord-295559-yc8q62z8	239	1	highlights	highlight	VBZ
cord-295559-yc8q62z8	239	2	its	-PRON-	PRP$
cord-295559-yc8q62z8	239	3	zoonotic	zoonotic	JJ
cord-295559-yc8q62z8	239	4	potential	potential	JJ
cord-295559-yc8q62z8	239	5	Global	global	JJ
cord-295559-yc8q62z8	239	6	trends	trend	NNS
cord-295559-yc8q62z8	239	7	in	in	IN
cord-295559-yc8q62z8	239	8	emerging	emerge	VBG
cord-295559-yc8q62z8	239	9	infectious	infectious	JJ
cord-295559-yc8q62z8	239	10	diseases	disease	NNS
cord-295559-yc8q62z8	239	11	Detection	detection	NN
cord-295559-yc8q62z8	239	12	of	of	IN
cord-295559-yc8q62z8	239	13	group	group	NN
cord-295559-yc8q62z8	239	14	1	1	CD
cord-295559-yc8q62z8	239	15	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	239	16	in	in	IN
cord-295559-yc8q62z8	239	17	bats	bat	NNS
cord-295559-yc8q62z8	239	18	in	in	IN
cord-295559-yc8q62z8	239	19	North	North	NNP
cord-295559-yc8q62z8	239	20	America	America	NNP
cord-295559-yc8q62z8	239	21	Metagenomic	Metagenomic	NNP
cord-295559-yc8q62z8	239	22	analysis	analysis	NN
cord-295559-yc8q62z8	239	23	of	of	IN
cord-295559-yc8q62z8	239	24	the	the	DT
cord-295559-yc8q62z8	239	25	viromes	virome	NNS
cord-295559-yc8q62z8	239	26	of	of	IN
cord-295559-yc8q62z8	239	27	three	three	CD
cord-295559-yc8q62z8	239	28	North	north	JJ
cord-295559-yc8q62z8	239	29	American	american	JJ
cord-295559-yc8q62z8	239	30	bat	bat	NN
cord-295559-yc8q62z8	239	31	species	specie	NNS
cord-295559-yc8q62z8	239	32	:	:	:
cord-295559-yc8q62z8	240	1	viral	viral	JJ
cord-295559-yc8q62z8	240	2	diversity	diversity	NN
cord-295559-yc8q62z8	240	3	among	among	IN
cord-295559-yc8q62z8	240	4	different	different	JJ
cord-295559-yc8q62z8	240	5	bat	bat	NN
cord-295559-yc8q62z8	240	6	species	specie	NNS
cord-295559-yc8q62z8	240	7	that	that	WDT
cord-295559-yc8q62z8	240	8	share	share	VBP
cord-295559-yc8q62z8	240	9	a	a	DT
cord-295559-yc8q62z8	240	10	common	common	JJ
cord-295559-yc8q62z8	240	11	habitat	habitat	NN
cord-295559-yc8q62z8	240	12	Detection	detection	NN
cord-295559-yc8q62z8	240	13	and	and	CC
cord-295559-yc8q62z8	240	14	phylogenetic	phylogenetic	JJ
cord-295559-yc8q62z8	240	15	analysis	analysis	NN
cord-295559-yc8q62z8	240	16	of	of	IN
cord-295559-yc8q62z8	240	17	group	group	NN
cord-295559-yc8q62z8	240	18	1	1	CD
cord-295559-yc8q62z8	240	19	coronaviruses	coronaviruse	NNS
cord-295559-yc8q62z8	240	20	in	in	IN
cord-295559-yc8q62z8	240	21	South	south	JJ
cord-295559-yc8q62z8	240	22	American	american	JJ
cord-295559-yc8q62z8	240	23	bats	bat	NNS
cord-295559-yc8q62z8	240	24	Alphacoronaviruses	Alphacoronaviruses	NNP
cord-295559-yc8q62z8	240	25	in	in	IN
cord-295559-yc8q62z8	240	26	New	New	NNP
cord-295559-yc8q62z8	240	27	World	World	NNP
cord-295559-yc8q62z8	240	28	bats	bat	NNS
cord-295559-yc8q62z8	240	29	:	:	:
cord-295559-yc8q62z8	240	30	prevalence	prevalence	NN
cord-295559-yc8q62z8	240	31	,	,	,
cord-295559-yc8q62z8	240	32	persistence	persistence	NN
cord-295559-yc8q62z8	240	33	,	,	,
cord-295559-yc8q62z8	240	34	phylogeny	phylogeny	NN
cord-295559-yc8q62z8	240	35	,	,	,
cord-295559-yc8q62z8	240	36	and	and	CC
cord-295559-yc8q62z8	240	37	potential	potential	NN
cord-295559-yc8q62z8	240	38	for	for	IN
cord-295559-yc8q62z8	240	39	interaction	interaction	NN
cord-295559-yc8q62z8	240	40	with	with	IN
cord-295559-yc8q62z8	240	41	humans	human	NNS
cord-295559-yc8q62z8	240	42	Crossreactive	Crossreactive	NNP
cord-295559-yc8q62z8	240	43	antibodies	antibody	NNS
cord-295559-yc8q62z8	240	44	in	in	IN
cord-295559-yc8q62z8	240	45	convalescent	convalescent	JJ
cord-295559-yc8q62z8	240	46	SARS	SARS	NNP
cord-295559-yc8q62z8	240	47	patients	patient	NNS
cord-295559-yc8q62z8	240	48	'	'	POS
cord-295559-yc8q62z8	240	49	sera	sera	NNP
cord-295559-yc8q62z8	240	50	against	against	IN
cord-295559-yc8q62z8	240	51	the	the	DT
cord-295559-yc8q62z8	240	52	emerging	emerge	VBG
cord-295559-yc8q62z8	240	53	novel	novel	JJ
cord-295559-yc8q62z8	240	54	human	human	JJ
cord-295559-yc8q62z8	240	55	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	240	56	EMC	EMC	NNP
cord-295559-yc8q62z8	240	57	(	(	-LRB-
cord-295559-yc8q62z8	240	58	2012	2012	CD
cord-295559-yc8q62z8	240	59	)	)	-RRB-
cord-295559-yc8q62z8	240	60	by	by	IN
cord-295559-yc8q62z8	240	61	both	both	DT
cord-295559-yc8q62z8	240	62	immunofluorescent	immunofluorescent	NN
cord-295559-yc8q62z8	240	63	and	and	CC
cord-295559-yc8q62z8	240	64	neutralizing	neutralize	VBG
cord-295559-yc8q62z8	240	65	antibody	antibody	NN
cord-295559-yc8q62z8	240	66	tests	test	NNS
cord-295559-yc8q62z8	240	67	Membrane	membrane	NN
cord-295559-yc8q62z8	240	68	fusion	fusion	NN
cord-295559-yc8q62z8	240	69	activity	activity	NN
cord-295559-yc8q62z8	240	70	of	of	IN
cord-295559-yc8q62z8	240	71	the	the	DT
cord-295559-yc8q62z8	240	72	influenza	influenza	NN
cord-295559-yc8q62z8	240	73	virus	virus	NN
cord-295559-yc8q62z8	240	74	hemagglutinin	hemagglutinin	NNP
cord-295559-yc8q62z8	240	75	.	.	.
cord-295559-yc8q62z8	241	1	The	the	DT
cord-295559-yc8q62z8	241	2	low	low	JJ
cord-295559-yc8q62z8	241	3	pH	ph	NN
cord-295559-yc8q62z8	241	4	-	-	HYPH
cord-295559-yc8q62z8	241	5	induced	induce	VBN
cord-295559-yc8q62z8	241	6	conformational	conformational	JJ
cord-295559-yc8q62z8	241	7	change	change	NN
cord-295559-yc8q62z8	241	8	Induction	Induction	NNP
cord-295559-yc8q62z8	241	9	of	of	IN
cord-295559-yc8q62z8	241	10	CD4-dependent	cd4-dependent	JJ
cord-295559-yc8q62z8	241	11	cell	cell	NN
cord-295559-yc8q62z8	241	12	fusion	fusion	NN
cord-295559-yc8q62z8	241	13	by	by	IN
cord-295559-yc8q62z8	241	14	the	the	DT
cord-295559-yc8q62z8	241	15	HTLV	HTLV	NNP
cord-295559-yc8q62z8	241	16	-	-	HYPH
cord-295559-yc8q62z8	241	17	III	III	NNP
cord-295559-yc8q62z8	241	18	/	/	SYM
cord-295559-yc8q62z8	241	19	LAV	LAV	NNP
cord-295559-yc8q62z8	241	20	envelope	envelope	NN
cord-295559-yc8q62z8	241	21	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	241	22	Retroviral	Retroviral	NNP
cord-295559-yc8q62z8	241	23	entry	entry	NN
cord-295559-yc8q62z8	241	24	mediated	mediate	VBN
cord-295559-yc8q62z8	241	25	by	by	IN
cord-295559-yc8q62z8	241	26	receptor	receptor	NN
cord-295559-yc8q62z8	241	27	priming	priming	NN
cord-295559-yc8q62z8	241	28	and	and	CC
cord-295559-yc8q62z8	241	29	low	low	JJ
cord-295559-yc8q62z8	241	30	pH	ph	NN
cord-295559-yc8q62z8	241	31	triggering	trigger	VBG
cord-295559-yc8q62z8	241	32	of	of	IN
cord-295559-yc8q62z8	241	33	an	an	DT
cord-295559-yc8q62z8	241	34	envelope	envelope	NN
cord-295559-yc8q62z8	241	35	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	241	36	Mechanisms	Mechanisms	NNPS
cord-295559-yc8q62z8	241	37	of	of	IN
cord-295559-yc8q62z8	241	38	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	241	39	cell	cell	NN
cord-295559-yc8q62z8	241	40	entry	entry	NN
cord-295559-yc8q62z8	241	41	mediated	mediate	VBN
cord-295559-yc8q62z8	241	42	by	by	IN
cord-295559-yc8q62z8	241	43	the	the	DT
cord-295559-yc8q62z8	241	44	viral	viral	JJ
cord-295559-yc8q62z8	241	45	spike	spike	NN
cord-295559-yc8q62z8	241	46	protein	protein	NN
cord-295559-yc8q62z8	241	47	Ready	Ready	NNP
cord-295559-yc8q62z8	241	48	,	,	,
cord-295559-yc8q62z8	241	49	set	set	VBN
cord-295559-yc8q62z8	241	50	,	,	,
cord-295559-yc8q62z8	241	51	fuse	fuse	NN
cord-295559-yc8q62z8	241	52	!	!	.
cord-295559-yc8q62z8	242	1	The	the	DT
cord-295559-yc8q62z8	242	2	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	242	3	spike	spike	NN
cord-295559-yc8q62z8	242	4	protein	protein	NN
cord-295559-yc8q62z8	242	5	and	and	CC
cord-295559-yc8q62z8	242	6	acquisition	acquisition	NN
cord-295559-yc8q62z8	242	7	of	of	IN
cord-295559-yc8q62z8	242	8	fusion	fusion	NN
cord-295559-yc8q62z8	242	9	competence	competence	NN
cord-295559-yc8q62z8	243	1	Conformational	Conformational	NNP
cord-295559-yc8q62z8	243	2	changes	change	NNS
cord-295559-yc8q62z8	243	3	in	in	IN
cord-295559-yc8q62z8	243	4	the	the	DT
cord-295559-yc8q62z8	243	5	spike	spike	NN
cord-295559-yc8q62z8	243	6	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	243	7	of	of	IN
cord-295559-yc8q62z8	243	8	murine	murine	JJ
cord-295559-yc8q62z8	243	9	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	243	10	are	be	VBP
cord-295559-yc8q62z8	243	11	induced	induce	VBN
cord-295559-yc8q62z8	243	12	at	at	IN
cord-295559-yc8q62z8	243	13	37	37	CD
cord-295559-yc8q62z8	243	14	degrees	degree	NNS
cord-295559-yc8q62z8	243	15	C	c	NN
cord-295559-yc8q62z8	243	16	either	either	CC
cord-295559-yc8q62z8	243	17	by	by	IN
cord-295559-yc8q62z8	243	18	soluble	soluble	JJ
cord-295559-yc8q62z8	243	19	murine	murine	JJ
cord-295559-yc8q62z8	243	20	CEACAM1	CEACAM1	NNP
cord-295559-yc8q62z8	243	21	receptors	receptor	NNS
cord-295559-yc8q62z8	243	22	or	or	CC
cord-295559-yc8q62z8	243	23	by	by	IN
cord-295559-yc8q62z8	243	24	pH	pH	NNP
cord-295559-yc8q62z8	243	25	8	8	CD
cord-295559-yc8q62z8	243	26	Proteasemediated	Proteasemediated	NNP
cord-295559-yc8q62z8	243	27	entry	entry	NN
cord-295559-yc8q62z8	243	28	via	via	IN
cord-295559-yc8q62z8	243	29	the	the	DT
cord-295559-yc8q62z8	243	30	endosome	endosome	NN
cord-295559-yc8q62z8	243	31	of	of	IN
cord-295559-yc8q62z8	243	32	human	human	JJ
cord-295559-yc8q62z8	243	33	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	243	34	229E	229e	CD
cord-295559-yc8q62z8	243	35	Cell	cell	NN
cord-295559-yc8q62z8	243	36	receptorindependent	receptorindependent	NN
cord-295559-yc8q62z8	243	37	infection	infection	NN
cord-295559-yc8q62z8	243	38	by	by	IN
cord-295559-yc8q62z8	243	39	a	a	DT
cord-295559-yc8q62z8	243	40	neurotropic	neurotropic	NNP
cord-295559-yc8q62z8	243	41	murine	murine	JJ
cord-295559-yc8q62z8	243	42	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	243	43	Entry	Entry	NNP
cord-295559-yc8q62z8	243	44	of	of	IN
cord-295559-yc8q62z8	243	45	mouse	mouse	NN
cord-295559-yc8q62z8	243	46	hepatitis	hepatitis	NN
cord-295559-yc8q62z8	243	47	virus	virus	NN
cord-295559-yc8q62z8	243	48	into	into	IN
cord-295559-yc8q62z8	243	49	cells	cell	NNS
cord-295559-yc8q62z8	243	50	by	by	IN
cord-295559-yc8q62z8	243	51	endosomal	endosomal	NNP
cord-295559-yc8q62z8	243	52	and	and	CC
cord-295559-yc8q62z8	243	53	nonendosomal	nonendosomal	NNP
cord-295559-yc8q62z8	243	54	pathways	pathway	NNS
cord-295559-yc8q62z8	244	1	The	the	DT
cord-295559-yc8q62z8	244	2	spike	spike	NN
cord-295559-yc8q62z8	244	3	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	244	4	of	of	IN
cord-295559-yc8q62z8	244	5	murine	murine	JJ
cord-295559-yc8q62z8	244	6	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	244	7	MHV	MHV	NNP
cord-295559-yc8q62z8	244	8	-	-	HYPH
cord-295559-yc8q62z8	244	9	JHM	JHM	NNP
cord-295559-yc8q62z8	244	10	mediates	mediate	VBZ
cord-295559-yc8q62z8	244	11	receptor	receptor	NN
cord-295559-yc8q62z8	244	12	-	-	HYPH
cord-295559-yc8q62z8	244	13	independent	independent	JJ
cord-295559-yc8q62z8	244	14	infection	infection	NN
cord-295559-yc8q62z8	244	15	and	and	CC
cord-295559-yc8q62z8	244	16	spread	spread	VBD
cord-295559-yc8q62z8	244	17	in	in	IN
cord-295559-yc8q62z8	244	18	the	the	DT
cord-295559-yc8q62z8	244	19	central	central	JJ
cord-295559-yc8q62z8	244	20	nervous	nervous	JJ
cord-295559-yc8q62z8	244	21	systems	system	NNS
cord-295559-yc8q62z8	244	22	of	of	IN
cord-295559-yc8q62z8	244	23	Ceacam1a-/-Mice	ceacam1a-/-mice	NN
cord-295559-yc8q62z8	245	1	Enhanced	enhanced	JJ
cord-295559-yc8q62z8	245	2	virulence	virulence	NN
cord-295559-yc8q62z8	245	3	mediated	mediate	VBN
cord-295559-yc8q62z8	245	4	by	by	IN
cord-295559-yc8q62z8	245	5	the	the	DT
cord-295559-yc8q62z8	245	6	murine	murine	JJ
cord-295559-yc8q62z8	245	7	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	245	8	,	,	,
cord-295559-yc8q62z8	245	9	mouse	mouse	NNP
cord-295559-yc8q62z8	245	10	hepatitis	hepatitis	NN
cord-295559-yc8q62z8	245	11	virus	virus	NN
cord-295559-yc8q62z8	245	12	strain	strain	NN
cord-295559-yc8q62z8	245	13	JHM	JHM	NNP
cord-295559-yc8q62z8	245	14	,	,	,
cord-295559-yc8q62z8	245	15	is	be	VBZ
cord-295559-yc8q62z8	245	16	associated	associate	VBN
cord-295559-yc8q62z8	245	17	with	with	IN
cord-295559-yc8q62z8	245	18	a	a	DT
cord-295559-yc8q62z8	245	19	glycine	glycine	NN
cord-295559-yc8q62z8	245	20	at	at	IN
cord-295559-yc8q62z8	245	21	residue	residue	NN
cord-295559-yc8q62z8	245	22	310	310	CD
cord-295559-yc8q62z8	245	23	of	of	IN
cord-295559-yc8q62z8	245	24	the	the	DT
cord-295559-yc8q62z8	245	25	spike	spike	NN
cord-295559-yc8q62z8	245	26	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	245	27	Escape	Escape	NNP
cord-295559-yc8q62z8	245	28	from	from	IN
cord-295559-yc8q62z8	245	29	human	human	JJ
cord-295559-yc8q62z8	245	30	monoclonal	monoclonal	JJ
cord-295559-yc8q62z8	245	31	antibody	antibody	NN
cord-295559-yc8q62z8	245	32	neutralization	neutralization	NN
cord-295559-yc8q62z8	245	33	affects	affect	VBZ
cord-295559-yc8q62z8	245	34	in	in	IN
cord-295559-yc8q62z8	245	35	vitro	vitro	FW
cord-295559-yc8q62z8	245	36	and	and	CC
cord-295559-yc8q62z8	245	37	in	in	IN
cord-295559-yc8q62z8	245	38	vivo	vivo	NN
cord-295559-yc8q62z8	245	39	fitness	fitness	NN
cord-295559-yc8q62z8	245	40	of	of	IN
cord-295559-yc8q62z8	245	41	severe	severe	JJ
cord-295559-yc8q62z8	245	42	acute	acute	JJ
cord-295559-yc8q62z8	245	43	respiratory	respiratory	JJ
cord-295559-yc8q62z8	245	44	syndrome	syndrome	NN
cord-295559-yc8q62z8	245	45	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	245	46	Severe	severe	JJ
cord-295559-yc8q62z8	245	47	acute	acute	JJ
cord-295559-yc8q62z8	245	48	respiratory	respiratory	JJ
cord-295559-yc8q62z8	245	49	syndrome	syndrome	NN
cord-295559-yc8q62z8	245	50	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	245	51	(	(	-LRB-
cord-295559-yc8q62z8	245	52	SARS	SARS	NNP
cord-295559-yc8q62z8	245	53	-	-	HYPH
cord-295559-yc8q62z8	245	54	CoV	CoV	NNP
cord-295559-yc8q62z8	245	55	)	)	-RRB-
cord-295559-yc8q62z8	246	1	infection	infection	NN
cord-295559-yc8q62z8	246	2	inhibition	inhibition	NN
cord-295559-yc8q62z8	246	3	using	use	VBG
cord-295559-yc8q62z8	246	4	spike	spike	NN
cord-295559-yc8q62z8	246	5	protein	protein	NN
cord-295559-yc8q62z8	246	6	heptad	heptad	NN
cord-295559-yc8q62z8	246	7	repeat	repeat	NN
cord-295559-yc8q62z8	246	8	-	-	HYPH
cord-295559-yc8q62z8	246	9	derived	derive	VBN
cord-295559-yc8q62z8	246	10	peptides	peptide	NNS
cord-295559-yc8q62z8	246	11	Requirements	requirement	NNS
cord-295559-yc8q62z8	246	12	for	for	IN
cord-295559-yc8q62z8	246	13	prediction	prediction	NN
cord-295559-yc8q62z8	246	14	of	of	IN
cord-295559-yc8q62z8	246	15	peptide	peptide	JJ
cord-295559-yc8q62z8	246	16	retention	retention	NN
cord-295559-yc8q62z8	246	17	time	time	NN
cord-295559-yc8q62z8	246	18	in	in	IN
cord-295559-yc8q62z8	246	19	reversed	reverse	VBN
cord-295559-yc8q62z8	246	20	-	-	HYPH
cord-295559-yc8q62z8	246	21	phase	phase	NN
cord-295559-yc8q62z8	246	22	high	high	JJ
cord-295559-yc8q62z8	246	23	-	-	HYPH
cord-295559-yc8q62z8	246	24	performance	performance	NN
cord-295559-yc8q62z8	246	25	liquid	liquid	NN
cord-295559-yc8q62z8	246	26	chromatography	chromatography	NN
cord-295559-yc8q62z8	246	27	:	:	:
cord-295559-yc8q62z8	246	28	hydrophilicity	hydrophilicity	NN
cord-295559-yc8q62z8	246	29	/	/	SYM
cord-295559-yc8q62z8	246	30	hydrophobicity	hydrophobicity	NN
cord-295559-yc8q62z8	246	31	of	of	IN
cord-295559-yc8q62z8	246	32	side	side	NN
cord-295559-yc8q62z8	246	33	-	-	HYPH
cord-295559-yc8q62z8	246	34	chains	chain	NNS
cord-295559-yc8q62z8	246	35	at	at	IN
cord-295559-yc8q62z8	246	36	the	the	DT
cord-295559-yc8q62z8	246	37	N	N	NNP
cord-295559-yc8q62z8	246	38	-	-	HYPH
cord-295559-yc8q62z8	246	39	and	and	CC
cord-295559-yc8q62z8	246	40	C	C	NNP
cord-295559-yc8q62z8	246	41	-	-	HYPH
cord-295559-yc8q62z8	246	42	termini	termini	NNP
cord-295559-yc8q62z8	246	43	of	of	IN
cord-295559-yc8q62z8	246	44	peptides	peptide	NNS
cord-295559-yc8q62z8	246	45	are	be	VBP
cord-295559-yc8q62z8	246	46	dramatically	dramatically	RB
cord-295559-yc8q62z8	246	47	affected	affect	VBN
cord-295559-yc8q62z8	246	48	by	by	IN
cord-295559-yc8q62z8	246	49	the	the	DT
cord-295559-yc8q62z8	246	50	end	end	NN
cord-295559-yc8q62z8	246	51	-	-	HYPH
cord-295559-yc8q62z8	246	52	groups	group	NNS
cord-295559-yc8q62z8	246	53	and	and	CC
cord-295559-yc8q62z8	247	1	location	location	NN
cord-295559-yc8q62z8	247	2	Apoptotic	Apoptotic	NNP
cord-295559-yc8q62z8	247	3	caspases	caspase	NNS
cord-295559-yc8q62z8	247	4	regulate	regulate	VBP
cord-295559-yc8q62z8	247	5	induction	induction	NN
cord-295559-yc8q62z8	247	6	of	of	IN
cord-295559-yc8q62z8	247	7	iPSCs	ipscs	CD
cord-295559-yc8q62z8	247	8	from	from	IN
cord-295559-yc8q62z8	247	9	human	human	JJ
cord-295559-yc8q62z8	247	10	fibroblasts	fibroblast	NNS
cord-295559-yc8q62z8	248	1	CD66	CD66	NNP
cord-295559-yc8q62z8	248	2	carcinoembryonic	carcinoembryonic	NNP
cord-295559-yc8q62z8	248	3	antigens	antigen	NNS
cord-295559-yc8q62z8	248	4	mediate	mediate	VBP
cord-295559-yc8q62z8	248	5	interactions	interaction	NNS
cord-295559-yc8q62z8	248	6	between	between	IN
cord-295559-yc8q62z8	248	7	Opaexpressing	Opaexpressing	NNP
cord-295559-yc8q62z8	248	8	Neisseria	Neisseria	NNP
cord-295559-yc8q62z8	248	9	gonorrhoeae	gonorrhoeae	NN
cord-295559-yc8q62z8	248	10	and	and	CC
cord-295559-yc8q62z8	248	11	human	human	JJ
cord-295559-yc8q62z8	248	12	polymorphonuclear	polymorphonuclear	NN
cord-295559-yc8q62z8	248	13	phagocytes	phagocyte	NNS
cord-295559-yc8q62z8	248	14	Human	Human	NNP
cord-295559-yc8q62z8	248	15	myeloid	myeloid	NN
cord-295559-yc8q62z8	248	16	plasma	plasma	NN
cord-295559-yc8q62z8	248	17	membrane	membrane	NN
cord-295559-yc8q62z8	248	18	glycoprotein	glycoprotein	NN
cord-295559-yc8q62z8	248	19	CD13	CD13	NNP
cord-295559-yc8q62z8	248	20	(	(	-LRB-
cord-295559-yc8q62z8	248	21	gp150	gp150	NNP
cord-295559-yc8q62z8	248	22	)	)	-RRB-
cord-295559-yc8q62z8	248	23	is	be	VBZ
cord-295559-yc8q62z8	248	24	identical	identical	JJ
cord-295559-yc8q62z8	248	25	to	to	IN
cord-295559-yc8q62z8	248	26	aminopeptidase	aminopeptidase	NN
cord-295559-yc8q62z8	248	27	N	N	NNP
cord-295559-yc8q62z8	248	28	Complementation	Complementation	NNP
cord-295559-yc8q62z8	248	29	of	of	IN
cord-295559-yc8q62z8	248	30	a	a	DT
cord-295559-yc8q62z8	248	31	binding	binding	JJ
cord-295559-yc8q62z8	248	32	-	-	HYPH
cord-295559-yc8q62z8	248	33	defective	defective	JJ
cord-295559-yc8q62z8	248	34	retrovirus	retrovirus	NN
cord-295559-yc8q62z8	248	35	by	by	IN
cord-295559-yc8q62z8	248	36	a	a	DT
cord-295559-yc8q62z8	248	37	host	host	NN
cord-295559-yc8q62z8	248	38	cell	cell	NN
cord-295559-yc8q62z8	248	39	receptor	receptor	NN
cord-295559-yc8q62z8	248	40	mutant	mutant	JJ
cord-295559-yc8q62z8	248	41	Isolation	isolation	NN
cord-295559-yc8q62z8	248	42	of	of	IN
cord-295559-yc8q62z8	248	43	coronavirus	coronavirus	NN
cord-295559-yc8q62z8	248	44	envelope	envelope	NN
cord-295559-yc8q62z8	248	45	glycoproteins	glycoprotein	NNS
cord-295559-yc8q62z8	248	46	and	and	CC
cord-295559-yc8q62z8	248	47	interaction	interaction	NN
cord-295559-yc8q62z8	248	48	with	with	IN
cord-295559-yc8q62z8	248	49	the	the	DT
cord-295559-yc8q62z8	248	50	viral	viral	JJ
cord-295559-yc8q62z8	248	51	nucleocapsid	nucleocapsid	NN
cord-295559-yc8q62z8	249	1	We	-PRON-	PRP
cord-295559-yc8q62z8	249	2	thank	thank	VBP
cord-295559-yc8q62z8	249	3	Scott	Scott	NNP
cord-295559-yc8q62z8	249	4	D.	D.	NNP
cord-295559-yc8q62z8	249	5	Gray	Gray	NNP
cord-295559-yc8q62z8	249	6	-	-	HYPH
cord-295559-yc8q62z8	249	7	Owen	Owen	NNP
cord-295559-yc8q62z8	249	8	(	(	-LRB-
cord-295559-yc8q62z8	249	9	University	University	NNP
cord-295559-yc8q62z8	249	10	of	of	IN
cord-295559-yc8q62z8	249	11	Toronto	Toronto	NNP
cord-295559-yc8q62z8	249	12	)	)	-RRB-
cord-295559-yc8q62z8	249	13	for	for	IN
cord-295559-yc8q62z8	249	14	providing	provide	VBG
cord-295559-yc8q62z8	249	15	HeLa	HeLa	NNP
cord-295559-yc8q62z8	249	16	cells	cell	NNS
cord-295559-yc8q62z8	249	17	stably	stably	RB
cord-295559-yc8q62z8	249	18	expressing	express	VBG
cord-295559-yc8q62z8	249	19	human	human	JJ
cord-295559-yc8q62z8	249	20	CEACAM	CEACAM	NNP
cord-295559-yc8q62z8	249	21	proteins	protein	NNS
cord-295559-yc8q62z8	249	22	,	,	,
cord-295559-yc8q62z8	249	23	Linda	Linda	NNP
cord-295559-yc8q62z8	249	24	Shapiro	Shapiro	NNP
cord-295559-yc8q62z8	249	25	(	(	-LRB-
cord-295559-yc8q62z8	249	26	University	University	NNP
cord-295559-yc8q62z8	249	27	of	of	IN
cord-295559-yc8q62z8	249	28	Connecticut	Connecticut	NNP
cord-295559-yc8q62z8	249	29	)	)	-RRB-
cord-295559-yc8q62z8	249	30	for	for	IN
cord-295559-yc8q62z8	249	31	mouse	mouse	NN
cord-295559-yc8q62z8	249	32	cells	cell	NNS
cord-295559-yc8q62z8	249	33	producing	produce	VBG
cord-295559-yc8q62z8	249	34	human	human	JJ
cord-295559-yc8q62z8	249	35	APN	APN	NNP
cord-295559-yc8q62z8	249	36	,	,	,
cord-295559-yc8q62z8	249	37	Richard	Richard	NNP
cord-295559-yc8q62z8	249	38	Bowen	Bowen	NNP
cord-295559-yc8q62z8	249	39	(	(	-LRB-
cord-295559-yc8q62z8	249	40	Colorado	Colorado	NNP
cord-295559-yc8q62z8	249	41	State	State	NNP
cord-295559-yc8q62z8	249	42	University	University	NNP
cord-295559-yc8q62z8	249	43	)	)	-RRB-
cord-295559-yc8q62z8	249	44	for	for	IN
cord-295559-yc8q62z8	249	45	the	the	DT
cord-295559-yc8q62z8	249	46	bat	bat	NN
cord-295559-yc8q62z8	249	47	cell	cell	NN
cord-295559-yc8q62z8	249	48	lines	line	NNS
cord-295559-yc8q62z8	249	49	,	,	,
cord-295559-yc8q62z8	249	50	Stefan	Stefan	NNP
cord-295559-yc8q62z8	249	51	Poehlmann	Poehlmann	NNP
cord-295559-yc8q62z8	249	52	(	(	-LRB-
cord-295559-yc8q62z8	249	53	Hannover	Hannover	NNP
cord-295559-yc8q62z8	249	54	Medical	Medical	NNP
cord-295559-yc8q62z8	249	55	School	School	NNP
cord-295559-yc8q62z8	249	56	and	and	CC
cord-295559-yc8q62z8	249	57	German	German	NNP
cord-295559-yc8q62z8	249	58	Primate	Primate	NNP
cord-295559-yc8q62z8	249	59	Center	Center	NNP
cord-295559-yc8q62z8	249	60	)	)	-RRB-
cord-295559-yc8q62z8	249	61	for	for	IN
cord-295559-yc8q62z8	249	62	pCA7-TMPRSS2	pCA7-TMPRSS2	NNP
cord-295559-yc8q62z8	249	63	and	and	CC
cord-295559-yc8q62z8	249	64	pCMV	pcmv	NN
cord-295559-yc8q62z8	249	65	-	-	HYPH
cord-295559-yc8q62z8	249	66	TMPRSS4	TMPRSS4	NNS
cord-295559-yc8q62z8	249	67	plasmids	plasmid	NNS
cord-295559-yc8q62z8	249	68	,	,	,
cord-295559-yc8q62z8	249	69	and	and	CC
cord-295559-yc8q62z8	249	70	Fang	Fang	NNP
cord-295559-yc8q62z8	249	71	Li	Li	NNP
cord-295559-yc8q62z8	249	72	(	(	-LRB-
cord-295559-yc8q62z8	249	73	Duke	Duke	NNP
cord-295559-yc8q62z8	249	74	University	University	NNP
cord-295559-yc8q62z8	249	75	)	)	-RRB-
cord-295559-yc8q62z8	249	76	for	for	IN
cord-295559-yc8q62z8	249	77	pLenti	pLenti	NNP
cord-295559-yc8q62z8	249	78	-	-	HYPH
cord-295559-yc8q62z8	249	79	GFP	GFP	NNP
cord-295559-yc8q62z8	249	80	-	-	HYPH
cord-295559-yc8q62z8	249	81	Luc	Luc	NNP
cord-295559-yc8q62z8	249	82	.	.	.
cord-295559-yc8q62z8	250	1	Conceived	conceive	VBN
cord-295559-yc8q62z8	250	2	and	and	CC
cord-295559-yc8q62z8	250	3	designed	design	VBD
cord-295559-yc8q62z8	250	4	the	the	DT
cord-295559-yc8q62z8	250	5	experiments	experiment	NNS
cord-295559-yc8q62z8	250	6	:	:	:
cord-295559-yc8q62z8	250	7	ZQ	ZQ	NNP
cord-295559-yc8q62z8	250	8	SRD	SRD	NNP
cord-295559-yc8q62z8	250	9	KVH	KVH	NNP
cord-295559-yc8q62z8	250	10	.	.	.
cord-295559-yc8q62z8	251	1	Performed	perform	VBN
cord-295559-yc8q62z8	251	2	the	the	DT
cord-295559-yc8q62z8	251	3	experiments	experiment	NNS
cord-295559-yc8q62z8	251	4	:	:	:
cord-295559-yc8q62z8	251	5	ZQ	ZQ	NNP
cord-295559-yc8q62z8	251	6	.	.	.
cord-295559-yc8q62z8	252	1	Analyzed	analyze	VBD
cord-295559-yc8q62z8	252	2	the	the	DT
cord-295559-yc8q62z8	252	3	data	datum	NNS
cord-295559-yc8q62z8	252	4	:	:	:
cord-295559-yc8q62z8	252	5	ZQ	ZQ	NNP
cord-295559-yc8q62z8	252	6	SRD	SRD	NNP
cord-295559-yc8q62z8	252	7	KVH	KVH	NNP
cord-295559-yc8q62z8	252	8	.	.	.
cord-295559-yc8q62z8	253	1	Contributed	contribute	VBN
cord-295559-yc8q62z8	253	2	reagents	reagent	NNS
cord-295559-yc8q62z8	253	3	/	/	SYM
cord-295559-yc8q62z8	253	4	materials	material	NNS
cord-295559-yc8q62z8	253	5	/	/	SYM
cord-295559-yc8q62z8	253	6	analysis	analysis	NN
cord-295559-yc8q62z8	253	7	tools	tool	NNS
cord-295559-yc8q62z8	253	8	:	:	:
cord-295559-yc8q62z8	253	9	ZQ	ZQ	NNP
cord-295559-yc8q62z8	253	10	SRD	SRD	NNP
cord-295559-yc8q62z8	253	11	KVH	KVH	NNP
cord-295559-yc8q62z8	253	12	.	.	.
cord-295559-yc8q62z8	254	1	Wrote	write	VBD
cord-295559-yc8q62z8	254	2	the	the	DT
cord-295559-yc8q62z8	254	3	manuscript	manuscript	NN
cord-295559-yc8q62z8	254	4	:	:	:
cord-295559-yc8q62z8	254	5	ZQ	ZQ	NNP
cord-295559-yc8q62z8	254	6	SRD	SRD	NNP
cord-295559-yc8q62z8	254	7	KVH	KVH	NNP
cord-295559-yc8q62z8	254	8	.	.	.