id sid tid token lemma pos cord-258172-p54j4zzo 1 1 key key JJ cord-258172-p54j4zzo 1 2 : : : cord-258172-p54j4zzo 1 3 cord-258172-p54j4zzo cord-258172-p54j4zzo NNP cord-258172-p54j4zzo 1 4 authors author NNS cord-258172-p54j4zzo 1 5 : : : cord-258172-p54j4zzo 1 6 Barker Barker NNP cord-258172-p54j4zzo 1 7 , , , cord-258172-p54j4zzo 1 8 Harlan Harlan NNP cord-258172-p54j4zzo 1 9 ; ; : cord-258172-p54j4zzo 1 10 Parkkila Parkkila NNP cord-258172-p54j4zzo 1 11 , , , cord-258172-p54j4zzo 1 12 Seppo Seppo NNP cord-258172-p54j4zzo 2 1 title title NN cord-258172-p54j4zzo 2 2 : : : cord-258172-p54j4zzo 3 1 Bioinformatic bioinformatic JJ cord-258172-p54j4zzo 3 2 characterization characterization NN cord-258172-p54j4zzo 3 3 of of IN cord-258172-p54j4zzo 3 4 angiotensin angiotensin NN cord-258172-p54j4zzo 3 5 - - HYPH cord-258172-p54j4zzo 3 6 converting convert VBG cord-258172-p54j4zzo 3 7 enzyme enzyme NN cord-258172-p54j4zzo 3 8 2 2 CD cord-258172-p54j4zzo 3 9 , , , cord-258172-p54j4zzo 3 10 the the DT cord-258172-p54j4zzo 3 11 entry entry NN cord-258172-p54j4zzo 3 12 receptor receptor NN cord-258172-p54j4zzo 3 13 for for IN cord-258172-p54j4zzo 3 14 SARS SARS NNP cord-258172-p54j4zzo 3 15 - - HYPH cord-258172-p54j4zzo 3 16 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 3 17 date date NN cord-258172-p54j4zzo 3 18 : : : cord-258172-p54j4zzo 3 19 2020 2020 CD cord-258172-p54j4zzo 3 20 - - SYM cord-258172-p54j4zzo 3 21 10 10 CD cord-258172-p54j4zzo 3 22 - - SYM cord-258172-p54j4zzo 3 23 28 28 CD cord-258172-p54j4zzo 3 24 journal journal NN cord-258172-p54j4zzo 3 25 : : : cord-258172-p54j4zzo 4 1 PLoS PLoS NNP cord-258172-p54j4zzo 5 1 One one CD cord-258172-p54j4zzo 5 2 DOI doi NN cord-258172-p54j4zzo 5 3 : : : cord-258172-p54j4zzo 5 4 10.1371 10.1371 CD cord-258172-p54j4zzo 5 5 / / SYM cord-258172-p54j4zzo 5 6 journal.pone.0240647 journal.pone.0240647 NNP cord-258172-p54j4zzo 5 7 sha sha NNP cord-258172-p54j4zzo 5 8 : : : cord-258172-p54j4zzo 5 9 84800a4467201da48ba8752f494ef967d8244b57 84800a4467201da48ba8752f494ef967d8244b57 CD cord-258172-p54j4zzo 5 10 doc_id doc_id CD cord-258172-p54j4zzo 5 11 : : : cord-258172-p54j4zzo 5 12 258172 258172 CD cord-258172-p54j4zzo 5 13 cord_uid cord_uid NNS cord-258172-p54j4zzo 5 14 : : : cord-258172-p54j4zzo 5 15 p54j4zzo p54j4zzo XX cord-258172-p54j4zzo 6 1 The the DT cord-258172-p54j4zzo 6 2 World World NNP cord-258172-p54j4zzo 6 3 Health Health NNP cord-258172-p54j4zzo 6 4 Organization Organization NNP cord-258172-p54j4zzo 6 5 declared declare VBD cord-258172-p54j4zzo 6 6 the the DT cord-258172-p54j4zzo 6 7 COVID-19 covid-19 JJ cord-258172-p54j4zzo 6 8 epidemic epidemic NN cord-258172-p54j4zzo 6 9 a a DT cord-258172-p54j4zzo 6 10 public public JJ cord-258172-p54j4zzo 6 11 health health NN cord-258172-p54j4zzo 6 12 emergency emergency NN cord-258172-p54j4zzo 6 13 of of IN cord-258172-p54j4zzo 6 14 international international JJ cord-258172-p54j4zzo 6 15 concern concern NN cord-258172-p54j4zzo 6 16 on on IN cord-258172-p54j4zzo 6 17 March March NNP cord-258172-p54j4zzo 6 18 11th 11th NN cord-258172-p54j4zzo 6 19 , , , cord-258172-p54j4zzo 6 20 2020 2020 CD cord-258172-p54j4zzo 6 21 , , , cord-258172-p54j4zzo 6 22 and and CC cord-258172-p54j4zzo 6 23 the the DT cord-258172-p54j4zzo 6 24 pandemic pandemic NN cord-258172-p54j4zzo 6 25 is be VBZ cord-258172-p54j4zzo 6 26 rapidly rapidly RB cord-258172-p54j4zzo 6 27 spreading spread VBG cord-258172-p54j4zzo 6 28 worldwide worldwide RB cord-258172-p54j4zzo 6 29 . . . cord-258172-p54j4zzo 7 1 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 7 2 is be VBZ cord-258172-p54j4zzo 7 3 caused cause VBN cord-258172-p54j4zzo 7 4 by by IN cord-258172-p54j4zzo 7 5 a a DT cord-258172-p54j4zzo 7 6 novel novel JJ cord-258172-p54j4zzo 7 7 coronavirus coronavirus NN cord-258172-p54j4zzo 7 8 SARS SARS NNP cord-258172-p54j4zzo 7 9 - - HYPH cord-258172-p54j4zzo 7 10 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 7 11 , , , cord-258172-p54j4zzo 7 12 which which WDT cord-258172-p54j4zzo 7 13 enters enter VBZ cord-258172-p54j4zzo 7 14 human human JJ cord-258172-p54j4zzo 7 15 target target NN cord-258172-p54j4zzo 7 16 cells cell NNS cord-258172-p54j4zzo 7 17 via via IN cord-258172-p54j4zzo 7 18 angiotensin angiotensin NN cord-258172-p54j4zzo 7 19 converting convert VBG cord-258172-p54j4zzo 7 20 enzyme enzyme NN cord-258172-p54j4zzo 7 21 2 2 CD cord-258172-p54j4zzo 7 22 ( ( -LRB- cord-258172-p54j4zzo 7 23 ACE2 ACE2 NNP cord-258172-p54j4zzo 7 24 ) ) -RRB- cord-258172-p54j4zzo 7 25 . . . cord-258172-p54j4zzo 8 1 We -PRON- PRP cord-258172-p54j4zzo 8 2 used use VBD cord-258172-p54j4zzo 8 3 a a DT cord-258172-p54j4zzo 8 4 number number NN cord-258172-p54j4zzo 8 5 of of IN cord-258172-p54j4zzo 8 6 bioinformatics bioinformatics NN cord-258172-p54j4zzo 8 7 tools tool NNS cord-258172-p54j4zzo 8 8 to to TO cord-258172-p54j4zzo 8 9 computationally computationally RB cord-258172-p54j4zzo 8 10 characterize characterize VB cord-258172-p54j4zzo 8 11 ACE2 ACE2 NNP cord-258172-p54j4zzo 8 12 by by IN cord-258172-p54j4zzo 8 13 determining determine VBG cord-258172-p54j4zzo 8 14 its -PRON- PRP$ cord-258172-p54j4zzo 8 15 cell cell NN cord-258172-p54j4zzo 8 16 - - HYPH cord-258172-p54j4zzo 8 17 specific specific JJ cord-258172-p54j4zzo 8 18 expression expression NN cord-258172-p54j4zzo 8 19 in in IN cord-258172-p54j4zzo 8 20 trachea trachea NN cord-258172-p54j4zzo 8 21 , , , cord-258172-p54j4zzo 8 22 lung lung NN cord-258172-p54j4zzo 8 23 , , , cord-258172-p54j4zzo 8 24 and and CC cord-258172-p54j4zzo 8 25 small small JJ cord-258172-p54j4zzo 8 26 intestine intestine NN cord-258172-p54j4zzo 8 27 , , , cord-258172-p54j4zzo 8 28 derive derive VB cord-258172-p54j4zzo 8 29 its -PRON- PRP$ cord-258172-p54j4zzo 8 30 putative putative JJ cord-258172-p54j4zzo 8 31 functions function NNS cord-258172-p54j4zzo 8 32 , , , cord-258172-p54j4zzo 8 33 and and CC cord-258172-p54j4zzo 8 34 predict predict VB cord-258172-p54j4zzo 8 35 transcriptional transcriptional JJ cord-258172-p54j4zzo 8 36 regulation regulation NN cord-258172-p54j4zzo 8 37 . . . cord-258172-p54j4zzo 9 1 The the DT cord-258172-p54j4zzo 9 2 small small JJ cord-258172-p54j4zzo 9 3 intestine intestine NN cord-258172-p54j4zzo 9 4 expressed express VBD cord-258172-p54j4zzo 9 5 higher high JJR cord-258172-p54j4zzo 9 6 levels level NNS cord-258172-p54j4zzo 9 7 of of IN cord-258172-p54j4zzo 9 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 9 9 mRNA mRNA NNP cord-258172-p54j4zzo 9 10 than than IN cord-258172-p54j4zzo 9 11 any any DT cord-258172-p54j4zzo 9 12 other other JJ cord-258172-p54j4zzo 9 13 organ organ NN cord-258172-p54j4zzo 9 14 . . . cord-258172-p54j4zzo 10 1 By by IN cord-258172-p54j4zzo 10 2 immunohistochemistry immunohistochemistry NN cord-258172-p54j4zzo 10 3 , , , cord-258172-p54j4zzo 10 4 duodenum duodenum NN cord-258172-p54j4zzo 10 5 , , , cord-258172-p54j4zzo 10 6 kidney kidney NN cord-258172-p54j4zzo 10 7 and and CC cord-258172-p54j4zzo 10 8 testis testis NN cord-258172-p54j4zzo 10 9 showed show VBD cord-258172-p54j4zzo 10 10 strong strong JJ cord-258172-p54j4zzo 10 11 signals signal NNS cord-258172-p54j4zzo 10 12 , , , cord-258172-p54j4zzo 10 13 whereas whereas IN cord-258172-p54j4zzo 10 14 the the DT cord-258172-p54j4zzo 10 15 signal signal NN cord-258172-p54j4zzo 10 16 was be VBD cord-258172-p54j4zzo 10 17 weak weak JJ cord-258172-p54j4zzo 10 18 in in IN cord-258172-p54j4zzo 10 19 the the DT cord-258172-p54j4zzo 10 20 respiratory respiratory JJ cord-258172-p54j4zzo 10 21 tract tract NN cord-258172-p54j4zzo 10 22 . . . cord-258172-p54j4zzo 11 1 Single single JJ cord-258172-p54j4zzo 11 2 cell cell NN cord-258172-p54j4zzo 11 3 RNA RNA NNP cord-258172-p54j4zzo 11 4 - - HYPH cord-258172-p54j4zzo 11 5 Seq Seq NNP cord-258172-p54j4zzo 11 6 data datum NNS cord-258172-p54j4zzo 11 7 from from IN cord-258172-p54j4zzo 11 8 trachea trachea NN cord-258172-p54j4zzo 11 9 indicated indicate VBD cord-258172-p54j4zzo 11 10 positive positive JJ cord-258172-p54j4zzo 11 11 signals signal NNS cord-258172-p54j4zzo 11 12 along along IN cord-258172-p54j4zzo 11 13 the the DT cord-258172-p54j4zzo 11 14 respiratory respiratory JJ cord-258172-p54j4zzo 11 15 tract tract NN cord-258172-p54j4zzo 11 16 in in IN cord-258172-p54j4zzo 11 17 key key JJ cord-258172-p54j4zzo 11 18 protective protective JJ cord-258172-p54j4zzo 11 19 cell cell NN cord-258172-p54j4zzo 11 20 types type NNS cord-258172-p54j4zzo 11 21 including include VBG cord-258172-p54j4zzo 11 22 club club NN cord-258172-p54j4zzo 11 23 , , , cord-258172-p54j4zzo 11 24 goblet goblet NN cord-258172-p54j4zzo 11 25 , , , cord-258172-p54j4zzo 11 26 proliferating proliferate VBG cord-258172-p54j4zzo 11 27 , , , cord-258172-p54j4zzo 11 28 and and CC cord-258172-p54j4zzo 11 29 ciliary ciliary NN cord-258172-p54j4zzo 11 30 epithelial epithelial JJ cord-258172-p54j4zzo 11 31 cells cell NNS cord-258172-p54j4zzo 11 32 ; ; : cord-258172-p54j4zzo 11 33 while while IN cord-258172-p54j4zzo 11 34 in in IN cord-258172-p54j4zzo 11 35 lung lung NN cord-258172-p54j4zzo 11 36 the the DT cord-258172-p54j4zzo 11 37 ratio ratio NN cord-258172-p54j4zzo 11 38 of of IN cord-258172-p54j4zzo 11 39 ACE2-expressing ace2-expresse VBG cord-258172-p54j4zzo 11 40 cells cell NNS cord-258172-p54j4zzo 11 41 was be VBD cord-258172-p54j4zzo 11 42 low low JJ cord-258172-p54j4zzo 11 43 in in IN cord-258172-p54j4zzo 11 44 all all DT cord-258172-p54j4zzo 11 45 cell cell NN cord-258172-p54j4zzo 11 46 types type NNS cord-258172-p54j4zzo 11 47 ( ( -LRB- cord-258172-p54j4zzo 11 48 < < NNP cord-258172-p54j4zzo 11 49 2.6 2.6 CD cord-258172-p54j4zzo 11 50 % % NN cord-258172-p54j4zzo 11 51 ) ) -RRB- cord-258172-p54j4zzo 11 52 , , , cord-258172-p54j4zzo 11 53 but but CC cord-258172-p54j4zzo 11 54 was be VBD cord-258172-p54j4zzo 11 55 highest high JJS cord-258172-p54j4zzo 11 56 in in IN cord-258172-p54j4zzo 11 57 vascular vascular JJ cord-258172-p54j4zzo 11 58 endothelial endothelial NN cord-258172-p54j4zzo 11 59 and and CC cord-258172-p54j4zzo 11 60 goblet goblet NN cord-258172-p54j4zzo 11 61 cells cell NNS cord-258172-p54j4zzo 11 62 . . . cord-258172-p54j4zzo 12 1 Gene gene NN cord-258172-p54j4zzo 12 2 ontology ontology NN cord-258172-p54j4zzo 12 3 analysis analysis NN cord-258172-p54j4zzo 12 4 suggested suggest VBD cord-258172-p54j4zzo 12 5 that that IN cord-258172-p54j4zzo 12 6 , , , cord-258172-p54j4zzo 12 7 besides besides IN cord-258172-p54j4zzo 12 8 its -PRON- PRP$ cord-258172-p54j4zzo 12 9 classical classical JJ cord-258172-p54j4zzo 12 10 role role NN cord-258172-p54j4zzo 12 11 in in IN cord-258172-p54j4zzo 12 12 the the DT cord-258172-p54j4zzo 12 13 renin renin NN cord-258172-p54j4zzo 12 14 - - HYPH cord-258172-p54j4zzo 12 15 angiotensin angiotensin NN cord-258172-p54j4zzo 12 16 system system NN cord-258172-p54j4zzo 12 17 , , , cord-258172-p54j4zzo 12 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 12 19 may may MD cord-258172-p54j4zzo 12 20 be be VB cord-258172-p54j4zzo 12 21 functionally functionally RB cord-258172-p54j4zzo 12 22 associated associate VBN cord-258172-p54j4zzo 12 23 with with IN cord-258172-p54j4zzo 12 24 angiogenesis angiogenesis NN cord-258172-p54j4zzo 12 25 / / SYM cord-258172-p54j4zzo 12 26 blood blood NN cord-258172-p54j4zzo 12 27 vessel vessel NN cord-258172-p54j4zzo 12 28 morphogenesis morphogenesis NN cord-258172-p54j4zzo 12 29 . . . cord-258172-p54j4zzo 13 1 Using use VBG cord-258172-p54j4zzo 13 2 a a DT cord-258172-p54j4zzo 13 3 novel novel JJ cord-258172-p54j4zzo 13 4 tool tool NN cord-258172-p54j4zzo 13 5 for for IN cord-258172-p54j4zzo 13 6 the the DT cord-258172-p54j4zzo 13 7 prediction prediction NN cord-258172-p54j4zzo 13 8 of of IN cord-258172-p54j4zzo 13 9 transcription transcription NN cord-258172-p54j4zzo 13 10 factor factor NN cord-258172-p54j4zzo 13 11 binding bind VBG cord-258172-p54j4zzo 13 12 sites site NNS cord-258172-p54j4zzo 13 13 we -PRON- PRP cord-258172-p54j4zzo 13 14 identified identify VBD cord-258172-p54j4zzo 13 15 several several JJ cord-258172-p54j4zzo 13 16 putative putative JJ cord-258172-p54j4zzo 13 17 binding binding JJ cord-258172-p54j4zzo 13 18 sites site NNS cord-258172-p54j4zzo 13 19 within within IN cord-258172-p54j4zzo 13 20 two two CD cord-258172-p54j4zzo 13 21 tissue tissue NN cord-258172-p54j4zzo 13 22 - - HYPH cord-258172-p54j4zzo 13 23 specific specific JJ cord-258172-p54j4zzo 13 24 promoters promoter NNS cord-258172-p54j4zzo 13 25 of of IN cord-258172-p54j4zzo 13 26 the the DT cord-258172-p54j4zzo 13 27 ACE2 ACE2 NNP cord-258172-p54j4zzo 13 28 gene gene NN cord-258172-p54j4zzo 13 29 as as RB cord-258172-p54j4zzo 13 30 well well RB cord-258172-p54j4zzo 13 31 as as IN cord-258172-p54j4zzo 13 32 a a DT cord-258172-p54j4zzo 13 33 new new JJ cord-258172-p54j4zzo 13 34 putative putative JJ cord-258172-p54j4zzo 13 35 short short JJ cord-258172-p54j4zzo 13 36 form form NN cord-258172-p54j4zzo 13 37 of of IN cord-258172-p54j4zzo 13 38 ACE2 ACE2 NNP cord-258172-p54j4zzo 13 39 . . . cord-258172-p54j4zzo 14 1 These these DT cord-258172-p54j4zzo 14 2 include include VBP cord-258172-p54j4zzo 14 3 several several JJ cord-258172-p54j4zzo 14 4 interferon interferon NN cord-258172-p54j4zzo 14 5 - - HYPH cord-258172-p54j4zzo 14 6 stimulated stimulate VBN cord-258172-p54j4zzo 14 7 response response NN cord-258172-p54j4zzo 14 8 elements element NNS cord-258172-p54j4zzo 14 9 sites site NNS cord-258172-p54j4zzo 14 10 for for IN cord-258172-p54j4zzo 14 11 STAT1 stat1 NN cord-258172-p54j4zzo 14 12 , , , cord-258172-p54j4zzo 14 13 IRF8 IRF8 NNP cord-258172-p54j4zzo 14 14 , , , cord-258172-p54j4zzo 14 15 and and CC cord-258172-p54j4zzo 14 16 IRF9 IRF9 NNP cord-258172-p54j4zzo 14 17 . . . cord-258172-p54j4zzo 15 1 Our -PRON- PRP$ cord-258172-p54j4zzo 15 2 results result NNS cord-258172-p54j4zzo 15 3 also also RB cord-258172-p54j4zzo 15 4 confirmed confirm VBD cord-258172-p54j4zzo 15 5 that that IN cord-258172-p54j4zzo 15 6 age age NN cord-258172-p54j4zzo 15 7 and and CC cord-258172-p54j4zzo 15 8 gender gender NN cord-258172-p54j4zzo 15 9 play play VBP cord-258172-p54j4zzo 15 10 no no DT cord-258172-p54j4zzo 15 11 significant significant JJ cord-258172-p54j4zzo 15 12 role role NN cord-258172-p54j4zzo 15 13 in in IN cord-258172-p54j4zzo 15 14 the the DT cord-258172-p54j4zzo 15 15 regulation regulation NN cord-258172-p54j4zzo 15 16 of of IN cord-258172-p54j4zzo 15 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 15 18 mRNA mRNA NNP cord-258172-p54j4zzo 15 19 expression expression NN cord-258172-p54j4zzo 15 20 in in IN cord-258172-p54j4zzo 15 21 the the DT cord-258172-p54j4zzo 15 22 lung lung NN cord-258172-p54j4zzo 15 23 . . . cord-258172-p54j4zzo 16 1 A a DT cord-258172-p54j4zzo 16 2 zinc zinc NN cord-258172-p54j4zzo 16 3 metalloenzyme metalloenzyme NNS cord-258172-p54j4zzo 16 4 , , , cord-258172-p54j4zzo 16 5 angiotensin angiotensin NN cord-258172-p54j4zzo 16 6 - - HYPH cord-258172-p54j4zzo 16 7 converting convert VBG cord-258172-p54j4zzo 16 8 enzyme enzyme NN cord-258172-p54j4zzo 16 9 ( ( -LRB- cord-258172-p54j4zzo 16 10 ACE ACE NNP cord-258172-p54j4zzo 16 11 ) ) -RRB- cord-258172-p54j4zzo 16 12 was be VBD cord-258172-p54j4zzo 16 13 discovered discover VBN cord-258172-p54j4zzo 16 14 64 64 CD cord-258172-p54j4zzo 16 15 years year NNS cord-258172-p54j4zzo 16 16 ago ago RB cord-258172-p54j4zzo 16 17 and and CC cord-258172-p54j4zzo 16 18 first first RB cord-258172-p54j4zzo 16 19 named name VBN cord-258172-p54j4zzo 16 20 as as IN cord-258172-p54j4zzo 16 21 a a DT cord-258172-p54j4zzo 16 22 hypertension hypertension NN cord-258172-p54j4zzo 16 23 - - HYPH cord-258172-p54j4zzo 16 24 converting convert VBG cord-258172-p54j4zzo 16 25 enzyme enzyme NN cord-258172-p54j4zzo 16 26 [ [ -LRB- cord-258172-p54j4zzo 16 27 1 1 CD cord-258172-p54j4zzo 16 28 ] ] -RRB- cord-258172-p54j4zzo 16 29 . . . cord-258172-p54j4zzo 17 1 Classically classically RB cord-258172-p54j4zzo 17 2 , , , cord-258172-p54j4zzo 17 3 ACE ACE NNP cord-258172-p54j4zzo 17 4 is be VBZ cord-258172-p54j4zzo 17 5 well well RB cord-258172-p54j4zzo 17 6 known know VBN cord-258172-p54j4zzo 17 7 for for IN cord-258172-p54j4zzo 17 8 its -PRON- PRP$ cord-258172-p54j4zzo 17 9 roles role NNS cord-258172-p54j4zzo 17 10 in in IN cord-258172-p54j4zzo 17 11 the the DT cord-258172-p54j4zzo 17 12 regulation regulation NN cord-258172-p54j4zzo 17 13 of of IN cord-258172-p54j4zzo 17 14 arterial arterial JJ cord-258172-p54j4zzo 17 15 pressure pressure NN cord-258172-p54j4zzo 17 16 through through IN cord-258172-p54j4zzo 17 17 conversion conversion NN cord-258172-p54j4zzo 17 18 of of IN cord-258172-p54j4zzo 17 19 angiotensin angiotensin NN cord-258172-p54j4zzo 17 20 I -PRON- PRP cord-258172-p54j4zzo 17 21 to to IN cord-258172-p54j4zzo 17 22 active active JJ cord-258172-p54j4zzo 17 23 angiotensin angiotensin NN cord-258172-p54j4zzo 17 24 II II NNP cord-258172-p54j4zzo 17 25 and and CC cord-258172-p54j4zzo 17 26 cleavage cleavage NN cord-258172-p54j4zzo 17 27 of of IN cord-258172-p54j4zzo 17 28 bradykinin bradykinin NN cord-258172-p54j4zzo 17 29 and and CC cord-258172-p54j4zzo 17 30 neurotensin neurotensin NNP cord-258172-p54j4zzo 17 31 [ [ -LRB- cord-258172-p54j4zzo 17 32 2 2 CD cord-258172-p54j4zzo 17 33 ] ] -RRB- cord-258172-p54j4zzo 17 34 . . . cord-258172-p54j4zzo 18 1 As as IN cord-258172-p54j4zzo 18 2 a a DT cord-258172-p54j4zzo 18 3 zinc zinc NN cord-258172-p54j4zzo 18 4 metalloenzyme metalloenzyme NNS cord-258172-p54j4zzo 18 5 , , , cord-258172-p54j4zzo 18 6 ACE ACE NNP cord-258172-p54j4zzo 18 7 belongs belong VBZ cord-258172-p54j4zzo 18 8 to to IN cord-258172-p54j4zzo 18 9 a a DT cord-258172-p54j4zzo 18 10 large large JJ cord-258172-p54j4zzo 18 11 cluster cluster NN cord-258172-p54j4zzo 18 12 of of IN cord-258172-p54j4zzo 18 13 zinc zinc NN cord-258172-p54j4zzo 18 14 - - HYPH cord-258172-p54j4zzo 18 15 binding bind VBG cord-258172-p54j4zzo 18 16 proteins protein NNS cord-258172-p54j4zzo 18 17 . . . cord-258172-p54j4zzo 19 1 The the DT cord-258172-p54j4zzo 19 2 first first JJ cord-258172-p54j4zzo 19 3 zinc zinc NN cord-258172-p54j4zzo 19 4 metalloenzyme metalloenzyme NNS cord-258172-p54j4zzo 19 5 , , , cord-258172-p54j4zzo 19 6 carbonic carbonic JJ cord-258172-p54j4zzo 19 7 anhydrase anhydrase NN cord-258172-p54j4zzo 19 8 was be VBD cord-258172-p54j4zzo 19 9 discovered discover VBN cord-258172-p54j4zzo 19 10 in in IN cord-258172-p54j4zzo 19 11 1932 1932 CD cord-258172-p54j4zzo 19 12 by by IN cord-258172-p54j4zzo 19 13 Meldrum Meldrum NNP cord-258172-p54j4zzo 19 14 and and CC cord-258172-p54j4zzo 19 15 Roughton Roughton NNP cord-258172-p54j4zzo 19 16 [ [ -LRB- cord-258172-p54j4zzo 19 17 3 3 CD cord-258172-p54j4zzo 19 18 ] ] -RRB- cord-258172-p54j4zzo 19 19 and and CC cord-258172-p54j4zzo 19 20 thereafter thereafter RB cord-258172-p54j4zzo 19 21 thousands thousand NNS cord-258172-p54j4zzo 19 22 of of IN cord-258172-p54j4zzo 19 23 such such JJ cord-258172-p54j4zzo 19 24 metalloenzymes metalloenzyme NNS cord-258172-p54j4zzo 19 25 have have VBP cord-258172-p54j4zzo 19 26 been be VBN cord-258172-p54j4zzo 19 27 reported report VBN cord-258172-p54j4zzo 19 28 in in IN cord-258172-p54j4zzo 19 29 different different JJ cord-258172-p54j4zzo 19 30 species specie NNS cord-258172-p54j4zzo 19 31 of of IN cord-258172-p54j4zzo 19 32 all all DT cord-258172-p54j4zzo 19 33 phyla phylum NNS cord-258172-p54j4zzo 19 34 [ [ -LRB- cord-258172-p54j4zzo 19 35 4 4 CD cord-258172-p54j4zzo 19 36 , , , cord-258172-p54j4zzo 19 37 5 5 CD cord-258172-p54j4zzo 19 38 ] ] -RRB- cord-258172-p54j4zzo 19 39 . . . cord-258172-p54j4zzo 20 1 Angiotensin angiotensin NN cord-258172-p54j4zzo 20 2 - - HYPH cord-258172-p54j4zzo 20 3 converting convert VBG cord-258172-p54j4zzo 20 4 enzyme enzyme NN cord-258172-p54j4zzo 20 5 2 2 CD cord-258172-p54j4zzo 20 6 ( ( -LRB- cord-258172-p54j4zzo 20 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 20 8 ) ) -RRB- cord-258172-p54j4zzo 20 9 was be VBD cord-258172-p54j4zzo 20 10 first first RB cord-258172-p54j4zzo 20 11 discovered discover VBN cord-258172-p54j4zzo 20 12 in in IN cord-258172-p54j4zzo 20 13 2000 2000 CD cord-258172-p54j4zzo 20 14 when when WRB cord-258172-p54j4zzo 20 15 a a DT cord-258172-p54j4zzo 20 16 novel novel JJ cord-258172-p54j4zzo 20 17 homologue homologue NN cord-258172-p54j4zzo 20 18 of of IN cord-258172-p54j4zzo 20 19 ACE ACE NNP cord-258172-p54j4zzo 20 20 was be VBD cord-258172-p54j4zzo 20 21 cloned clone VBN cord-258172-p54j4zzo 20 22 [ [ -LRB- cord-258172-p54j4zzo 20 23 2 2 CD cord-258172-p54j4zzo 20 24 , , , cord-258172-p54j4zzo 20 25 6 6 CD cord-258172-p54j4zzo 20 26 , , , cord-258172-p54j4zzo 20 27 7 7 CD cord-258172-p54j4zzo 20 28 ] ] -RRB- cord-258172-p54j4zzo 20 29 . . . cord-258172-p54j4zzo 21 1 Although although IN cord-258172-p54j4zzo 21 2 ACE ACE NNP cord-258172-p54j4zzo 21 3 and and CC cord-258172-p54j4zzo 21 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 21 5 share share VBP cord-258172-p54j4zzo 21 6 significant significant JJ cord-258172-p54j4zzo 21 7 sequence sequence NN cord-258172-p54j4zzo 21 8 similarity similarity NN cord-258172-p54j4zzo 21 9 in in IN cord-258172-p54j4zzo 21 10 their -PRON- PRP$ cord-258172-p54j4zzo 21 11 catalytic catalytic JJ cord-258172-p54j4zzo 21 12 domains domain NNS cord-258172-p54j4zzo 21 13 , , , cord-258172-p54j4zzo 21 14 they -PRON- PRP cord-258172-p54j4zzo 21 15 appear appear VBP cord-258172-p54j4zzo 21 16 to to TO cord-258172-p54j4zzo 21 17 act act VB cord-258172-p54j4zzo 21 18 on on IN cord-258172-p54j4zzo 21 19 different different JJ cord-258172-p54j4zzo 21 20 peptide peptide NN cord-258172-p54j4zzo 21 21 substrates substrate NNS cord-258172-p54j4zzo 21 22 of of IN cord-258172-p54j4zzo 21 23 angiotensins angiotensin NNS cord-258172-p54j4zzo 21 24 [ [ -LRB- cord-258172-p54j4zzo 21 25 8 8 CD cord-258172-p54j4zzo 21 26 , , , cord-258172-p54j4zzo 21 27 9 9 CD cord-258172-p54j4zzo 21 28 ] ] -RRB- cord-258172-p54j4zzo 21 29 . . . cord-258172-p54j4zzo 22 1 Previous previous JJ cord-258172-p54j4zzo 22 2 studies study NNS cord-258172-p54j4zzo 22 3 identified identify VBD cord-258172-p54j4zzo 22 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 22 5 as as IN cord-258172-p54j4zzo 22 6 a a DT cord-258172-p54j4zzo 22 7 functional functional JJ cord-258172-p54j4zzo 22 8 receptor receptor NN cord-258172-p54j4zzo 22 9 for for IN cord-258172-p54j4zzo 22 10 severe severe JJ cord-258172-p54j4zzo 22 11 acute acute JJ cord-258172-p54j4zzo 22 12 respiratory respiratory JJ cord-258172-p54j4zzo 22 13 syndrome syndrome NN cord-258172-p54j4zzo 22 14 corona corona NNP cord-258172-p54j4zzo 22 15 virus virus NN cord-258172-p54j4zzo 22 16 1 1 CD cord-258172-p54j4zzo 22 17 ( ( -LRB- cord-258172-p54j4zzo 22 18 SARS SARS NNP cord-258172-p54j4zzo 22 19 - - HYPH cord-258172-p54j4zzo 22 20 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 22 21 ) ) -RRB- cord-258172-p54j4zzo 22 22 which which WDT cord-258172-p54j4zzo 22 23 led lead VBD cord-258172-p54j4zzo 22 24 to to IN cord-258172-p54j4zzo 22 25 an an DT cord-258172-p54j4zzo 22 26 outbreak outbreak NN cord-258172-p54j4zzo 22 27 of of IN cord-258172-p54j4zzo 22 28 SARS SARS NNP cord-258172-p54j4zzo 22 29 infection infection NN cord-258172-p54j4zzo 22 30 in in IN cord-258172-p54j4zzo 22 31 2003 2003 CD cord-258172-p54j4zzo 22 32 [ [ -LRB- cord-258172-p54j4zzo 22 33 10 10 CD cord-258172-p54j4zzo 22 34 ] ] -RRB- cord-258172-p54j4zzo 22 35 . . . cord-258172-p54j4zzo 23 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 23 2 is be VBZ cord-258172-p54j4zzo 23 3 also also RB cord-258172-p54j4zzo 23 4 a a DT cord-258172-p54j4zzo 23 5 crucial crucial JJ cord-258172-p54j4zzo 23 6 receptor receptor NN cord-258172-p54j4zzo 23 7 for for IN cord-258172-p54j4zzo 23 8 the the DT cord-258172-p54j4zzo 23 9 novel novel JJ cord-258172-p54j4zzo 23 10 corona corona NN cord-258172-p54j4zzo 23 11 virus virus NN cord-258172-p54j4zzo 23 12 ( ( -LRB- cord-258172-p54j4zzo 23 13 SARS SARS NNP cord-258172-p54j4zzo 23 14 - - HYPH cord-258172-p54j4zzo 23 15 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 23 16 ) ) -RRB- cord-258172-p54j4zzo 23 17 , , , cord-258172-p54j4zzo 23 18 which which WDT cord-258172-p54j4zzo 23 19 has have VBZ cord-258172-p54j4zzo 23 20 caused cause VBN cord-258172-p54j4zzo 23 21 a a DT cord-258172-p54j4zzo 23 22 large large JJ cord-258172-p54j4zzo 23 23 global global JJ cord-258172-p54j4zzo 23 24 outbreak outbreak NN cord-258172-p54j4zzo 23 25 of of IN cord-258172-p54j4zzo 23 26 COVID-19 covid-19 JJ cord-258172-p54j4zzo 23 27 infection infection NN cord-258172-p54j4zzo 23 28 with with IN cord-258172-p54j4zzo 23 29 rapidly rapidly RB cord-258172-p54j4zzo 23 30 growing grow VBG cord-258172-p54j4zzo 23 31 numbers number NNS cord-258172-p54j4zzo 23 32 of of IN cord-258172-p54j4zzo 23 33 patients patient NNS cord-258172-p54j4zzo 23 34 ( ( -LRB- cord-258172-p54j4zzo 23 35 32 32 CD cord-258172-p54j4zzo 23 36 , , , cord-258172-p54j4zzo 23 37 968 968 CD cord-258172-p54j4zzo 23 38 , , , cord-258172-p54j4zzo 23 39 853 853 CD cord-258172-p54j4zzo 23 40 confirmed confirm VBN cord-258172-p54j4zzo 23 41 cases case NNS cord-258172-p54j4zzo 23 42 as as IN cord-258172-p54j4zzo 23 43 of of IN cord-258172-p54j4zzo 23 44 September September NNP cord-258172-p54j4zzo 23 45 28 28 CD cord-258172-p54j4zzo 23 46 th th XX cord-258172-p54j4zzo 23 47 , , , cord-258172-p54j4zzo 23 48 2020 2020 CD cord-258172-p54j4zzo 23 49 , , , cord-258172-p54j4zzo 23 50 https://www.who.int/ https://www.who.int/ NNP cord-258172-p54j4zzo 23 51 emergencies emergency NNS cord-258172-p54j4zzo 23 52 / / SYM cord-258172-p54j4zzo 23 53 diseases disease NNS cord-258172-p54j4zzo 23 54 / / SYM cord-258172-p54j4zzo 23 55 novel novel NN cord-258172-p54j4zzo 23 56 - - : cord-258172-p54j4zzo 23 57 coronavirus-2019 coronavirus-2019 NNP cord-258172-p54j4zzo 23 58 ) ) -RRB- cord-258172-p54j4zzo 23 59 . . . cord-258172-p54j4zzo 24 1 A a DT cord-258172-p54j4zzo 24 2 recent recent JJ cord-258172-p54j4zzo 24 3 report report NN cord-258172-p54j4zzo 24 4 suggested suggest VBD cord-258172-p54j4zzo 24 5 that that IN cord-258172-p54j4zzo 24 6 soluble soluble JJ cord-258172-p54j4zzo 24 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 24 8 fused fuse VBD cord-258172-p54j4zzo 24 9 to to IN cord-258172-p54j4zzo 24 10 the the DT cord-258172-p54j4zzo 24 11 Fc Fc NNP cord-258172-p54j4zzo 24 12 portion portion NN cord-258172-p54j4zzo 24 13 of of IN cord-258172-p54j4zzo 24 14 immunoglobulin immunoglobulin NN cord-258172-p54j4zzo 24 15 can can MD cord-258172-p54j4zzo 24 16 neutralize neutralize VB cord-258172-p54j4zzo 24 17 SARS SARS NNP cord-258172-p54j4zzo 24 18 - - HYPH cord-258172-p54j4zzo 24 19 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 24 20 in in IN cord-258172-p54j4zzo 24 21 vitro vitro FW cord-258172-p54j4zzo 24 22 [ [ -LRB- cord-258172-p54j4zzo 24 23 11 11 CD cord-258172-p54j4zzo 24 24 ] ] -RRB- cord-258172-p54j4zzo 24 25 . . . cord-258172-p54j4zzo 25 1 This this DT cord-258172-p54j4zzo 25 2 result result NN cord-258172-p54j4zzo 25 3 was be VBD cord-258172-p54j4zzo 25 4 further further RB cord-258172-p54j4zzo 25 5 confirmed confirm VBN cord-258172-p54j4zzo 25 6 by by IN cord-258172-p54j4zzo 25 7 showing show VBG cord-258172-p54j4zzo 25 8 that that DT cord-258172-p54j4zzo 25 9 human human JJ cord-258172-p54j4zzo 25 10 recombinant recombinant NN cord-258172-p54j4zzo 25 11 soluble soluble JJ cord-258172-p54j4zzo 25 12 ACE2 ACE2 NNP cord-258172-p54j4zzo 25 13 reduced reduce VBN cord-258172-p54j4zzo 25 14 SARS SARS NNP cord-258172-p54j4zzo 25 15 - - HYPH cord-258172-p54j4zzo 25 16 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 25 17 infection infection NN cord-258172-p54j4zzo 25 18 on on IN cord-258172-p54j4zzo 25 19 cultured cultured JJ cord-258172-p54j4zzo 25 20 Vero Vero NNP cord-258172-p54j4zzo 25 21 - - HYPH cord-258172-p54j4zzo 25 22 E6 E6 NNP cord-258172-p54j4zzo 25 23 cells cell NNS cord-258172-p54j4zzo 25 24 in in IN cord-258172-p54j4zzo 25 25 a a DT cord-258172-p54j4zzo 25 26 dose dose NN cord-258172-p54j4zzo 25 27 dependent dependent JJ cord-258172-p54j4zzo 25 28 manner manner NN cord-258172-p54j4zzo 25 29 [ [ -LRB- cord-258172-p54j4zzo 25 30 12 12 CD cord-258172-p54j4zzo 25 31 ] ] -RRB- cord-258172-p54j4zzo 25 32 . . . cord-258172-p54j4zzo 26 1 Therefore therefore RB cord-258172-p54j4zzo 26 2 , , , cord-258172-p54j4zzo 26 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 26 4 also also RB cord-258172-p54j4zzo 26 5 holds hold VBZ cord-258172-p54j4zzo 26 6 promise promise NN cord-258172-p54j4zzo 26 7 for for IN cord-258172-p54j4zzo 26 8 treating treat VBG cord-258172-p54j4zzo 26 9 patients patient NNS cord-258172-p54j4zzo 26 10 with with IN cord-258172-p54j4zzo 26 11 coronavirus coronavirus NN cord-258172-p54j4zzo 26 12 infection infection NN cord-258172-p54j4zzo 26 13 . . . cord-258172-p54j4zzo 27 1 The the DT cord-258172-p54j4zzo 27 2 structural structural JJ cord-258172-p54j4zzo 27 3 key key NN cord-258172-p54j4zzo 27 4 for for IN cord-258172-p54j4zzo 27 5 target target NN cord-258172-p54j4zzo 27 6 cell cell NN cord-258172-p54j4zzo 27 7 infection infection NN cord-258172-p54j4zzo 27 8 by by IN cord-258172-p54j4zzo 27 9 coronavirus coronavirus NN cord-258172-p54j4zzo 27 10 is be VBZ cord-258172-p54j4zzo 27 11 the the DT cord-258172-p54j4zzo 27 12 viral viral JJ cord-258172-p54j4zzo 27 13 spike spike NN cord-258172-p54j4zzo 27 14 ( ( -LRB- cord-258172-p54j4zzo 27 15 S s NN cord-258172-p54j4zzo 27 16 ) ) -RRB- cord-258172-p54j4zzo 27 17 protein protein NN cord-258172-p54j4zzo 27 18 of of IN cord-258172-p54j4zzo 27 19 SARS SARS NNP cord-258172-p54j4zzo 27 20 - - HYPH cord-258172-p54j4zzo 27 21 CoV. CoV. NNP cord-258172-p54j4zzo 27 22 ACE2 ACE2 NNP cord-258172-p54j4zzo 27 23 acts act NNS cord-258172-p54j4zzo 27 24 as as IN cord-258172-p54j4zzo 27 25 a a DT cord-258172-p54j4zzo 27 26 locking locking NN cord-258172-p54j4zzo 27 27 device device NN cord-258172-p54j4zzo 27 28 for for IN cord-258172-p54j4zzo 27 29 the the DT cord-258172-p54j4zzo 27 30 virus virus NN cord-258172-p54j4zzo 27 31 , , , cord-258172-p54j4zzo 27 32 whereby whereby WRB cord-258172-p54j4zzo 27 33 the the DT cord-258172-p54j4zzo 27 34 binding binding NN cord-258172-p54j4zzo 27 35 of of IN cord-258172-p54j4zzo 27 36 the the DT cord-258172-p54j4zzo 27 37 surface surface NN cord-258172-p54j4zzo 27 38 unit unit NN cord-258172-p54j4zzo 27 39 S1 s1 NN cord-258172-p54j4zzo 27 40 facilitates facilitate VBZ cord-258172-p54j4zzo 27 41 viral viral JJ cord-258172-p54j4zzo 27 42 attachment attachment NN cord-258172-p54j4zzo 27 43 to to IN cord-258172-p54j4zzo 27 44 the the DT cord-258172-p54j4zzo 27 45 surface surface NN cord-258172-p54j4zzo 27 46 of of IN cord-258172-p54j4zzo 27 47 target target NN cord-258172-p54j4zzo 27 48 cells cell NNS cord-258172-p54j4zzo 27 49 [ [ -LRB- cord-258172-p54j4zzo 27 50 13 13 CD cord-258172-p54j4zzo 27 51 ] ] -RRB- cord-258172-p54j4zzo 27 52 . . . cord-258172-p54j4zzo 28 1 The the DT cord-258172-p54j4zzo 28 2 cellular cellular JJ cord-258172-p54j4zzo 28 3 serine serine NN cord-258172-p54j4zzo 28 4 protease protease NN cord-258172-p54j4zzo 28 5 ( ( -LRB- cord-258172-p54j4zzo 28 6 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 28 7 ) ) -RRB- cord-258172-p54j4zzo 28 8 promotes promote VBZ cord-258172-p54j4zzo 28 9 SARS SARS NNP cord-258172-p54j4zzo 28 10 - - HYPH cord-258172-p54j4zzo 28 11 CoV CoV NNP cord-258172-p54j4zzo 28 12 entry entry NN cord-258172-p54j4zzo 28 13 via via IN cord-258172-p54j4zzo 28 14 a a DT cord-258172-p54j4zzo 28 15 dual dual JJ cord-258172-p54j4zzo 28 16 mechanism mechanism NN cord-258172-p54j4zzo 28 17 . . . cord-258172-p54j4zzo 29 1 It -PRON- PRP cord-258172-p54j4zzo 29 2 cleaves cleave VBZ cord-258172-p54j4zzo 29 3 both both CC cord-258172-p54j4zzo 29 4 the the DT cord-258172-p54j4zzo 29 5 SARS SARS NNP cord-258172-p54j4zzo 29 6 - - HYPH cord-258172-p54j4zzo 29 7 CoV CoV NNP cord-258172-p54j4zzo 29 8 S S NNP cord-258172-p54j4zzo 29 9 protein protein NN cord-258172-p54j4zzo 29 10 and and CC cord-258172-p54j4zzo 29 11 the the DT cord-258172-p54j4zzo 29 12 virus virus NN cord-258172-p54j4zzo 29 13 receptor receptor NN cord-258172-p54j4zzo 29 14 , , , cord-258172-p54j4zzo 29 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 29 16 , , , cord-258172-p54j4zzo 29 17 promoting promote VBG cord-258172-p54j4zzo 29 18 both both CC cord-258172-p54j4zzo 29 19 the the DT cord-258172-p54j4zzo 29 20 viral viral JJ cord-258172-p54j4zzo 29 21 uptake uptake NN cord-258172-p54j4zzo 29 22 and and CC cord-258172-p54j4zzo 29 23 the the DT cord-258172-p54j4zzo 29 24 viral viral JJ cord-258172-p54j4zzo 29 25 and and CC cord-258172-p54j4zzo 29 26 cellular cellular JJ cord-258172-p54j4zzo 29 27 membrane membrane NN cord-258172-p54j4zzo 29 28 fusion fusion NN cord-258172-p54j4zzo 29 29 events event NNS cord-258172-p54j4zzo 29 30 [ [ -LRB- cord-258172-p54j4zzo 29 31 13 13 CD cord-258172-p54j4zzo 29 32 ] ] -RRB- cord-258172-p54j4zzo 29 33 [ [ -LRB- cord-258172-p54j4zzo 29 34 14 14 CD cord-258172-p54j4zzo 29 35 ] ] -RRB- cord-258172-p54j4zzo 29 36 [ [ -LRB- cord-258172-p54j4zzo 29 37 15 15 CD cord-258172-p54j4zzo 29 38 ] ] -RRB- cord-258172-p54j4zzo 29 39 . . . cord-258172-p54j4zzo 30 1 The the DT cord-258172-p54j4zzo 30 2 critical critical JJ cord-258172-p54j4zzo 30 3 residues residue NNS cord-258172-p54j4zzo 30 4 contributing contribute VBG cord-258172-p54j4zzo 30 5 to to IN cord-258172-p54j4zzo 30 6 the the DT cord-258172-p54j4zzo 30 7 receptor receptor NN cord-258172-p54j4zzo 30 8 - - HYPH cord-258172-p54j4zzo 30 9 spike spike NN cord-258172-p54j4zzo 30 10 protein protein NN cord-258172-p54j4zzo 30 11 interaction interaction NN cord-258172-p54j4zzo 30 12 were be VBD cord-258172-p54j4zzo 30 13 first first RB cord-258172-p54j4zzo 30 14 determined determined JJ cord-258172-p54j4zzo 30 15 for for IN cord-258172-p54j4zzo 30 16 SARS SARS NNP cord-258172-p54j4zzo 30 17 - - HYPH cord-258172-p54j4zzo 30 18 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 30 19 [ [ -LRB- cord-258172-p54j4zzo 30 20 16 16 CD cord-258172-p54j4zzo 30 21 ] ] -RRB- cord-258172-p54j4zzo 30 22 and and CC cord-258172-p54j4zzo 30 23 recently recently RB cord-258172-p54j4zzo 30 24 in in IN cord-258172-p54j4zzo 30 25 three three CD cord-258172-p54j4zzo 30 26 independent independent JJ cord-258172-p54j4zzo 30 27 studies study NNS cord-258172-p54j4zzo 30 28 for for IN cord-258172-p54j4zzo 30 29 SARS SARS NNP cord-258172-p54j4zzo 30 30 - - HYPH cord-258172-p54j4zzo 30 31 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 30 32 [ [ -LRB- cord-258172-p54j4zzo 30 33 17 17 CD cord-258172-p54j4zzo 30 34 ] ] -RRB- cord-258172-p54j4zzo 30 35 [ [ -LRB- cord-258172-p54j4zzo 30 36 18 18 CD cord-258172-p54j4zzo 30 37 ] ] -RRB- cord-258172-p54j4zzo 30 38 [ [ -LRB- cord-258172-p54j4zzo 30 39 19 19 CD cord-258172-p54j4zzo 30 40 ] ] -RRB- cord-258172-p54j4zzo 30 41 . . . cord-258172-p54j4zzo 31 1 It -PRON- PRP cord-258172-p54j4zzo 31 2 has have VBZ cord-258172-p54j4zzo 31 3 been be VBN cord-258172-p54j4zzo 31 4 proposed propose VBN cord-258172-p54j4zzo 31 5 by by IN cord-258172-p54j4zzo 31 6 biolayer biolayer NNP cord-258172-p54j4zzo 31 7 interferometry interferometry NNP cord-258172-p54j4zzo 31 8 studies study NNS cord-258172-p54j4zzo 31 9 that that IN cord-258172-p54j4zzo 31 10 the the DT cord-258172-p54j4zzo 31 11 receptor receptor NN cord-258172-p54j4zzo 31 12 - - HYPH cord-258172-p54j4zzo 31 13 binding bind VBG cord-258172-p54j4zzo 31 14 domains domain NNS cord-258172-p54j4zzo 31 15 of of IN cord-258172-p54j4zzo 31 16 SARS SARS NNP cord-258172-p54j4zzo 31 17 - - HYPH cord-258172-p54j4zzo 31 18 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 31 19 and and CC cord-258172-p54j4zzo 31 20 SARS SARS NNP cord-258172-p54j4zzo 31 21 - - HYPH cord-258172-p54j4zzo 31 22 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 31 23 S S NNP cord-258172-p54j4zzo 31 24 proteins protein NNS cord-258172-p54j4zzo 31 25 bind bind VBP cord-258172-p54j4zzo 31 26 with with IN cord-258172-p54j4zzo 31 27 comparable comparable JJ cord-258172-p54j4zzo 31 28 affinities affinity NNS cord-258172-p54j4zzo 31 29 to to IN cord-258172-p54j4zzo 31 30 human human JJ cord-258172-p54j4zzo 31 31 ACE2 ACE2 NNP cord-258172-p54j4zzo 31 32 [ [ -LRB- cord-258172-p54j4zzo 31 33 20 20 CD cord-258172-p54j4zzo 31 34 ] ] -RRB- cord-258172-p54j4zzo 31 35 . . . cord-258172-p54j4zzo 32 1 In in IN cord-258172-p54j4zzo 32 2 contrast contrast NN cord-258172-p54j4zzo 32 3 , , , cord-258172-p54j4zzo 32 4 a a DT cord-258172-p54j4zzo 32 5 modelling modelling NN cord-258172-p54j4zzo 32 6 study study NN cord-258172-p54j4zzo 32 7 suggested suggest VBD cord-258172-p54j4zzo 32 8 that that IN cord-258172-p54j4zzo 32 9 binding binding NN cord-258172-p54j4zzo 32 10 of of IN cord-258172-p54j4zzo 32 11 SARS SARS NNP cord-258172-p54j4zzo 32 12 - - HYPH cord-258172-p54j4zzo 32 13 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 32 14 is be VBZ cord-258172-p54j4zzo 32 15 stronger strong JJR cord-258172-p54j4zzo 32 16 [ [ -LRB- cord-258172-p54j4zzo 32 17 21 21 CD cord-258172-p54j4zzo 32 18 ] ] -RRB- cord-258172-p54j4zzo 32 19 , , , cord-258172-p54j4zzo 32 20 which which WDT cord-258172-p54j4zzo 32 21 was be VBD cord-258172-p54j4zzo 32 22 convincingly convincingly RB cord-258172-p54j4zzo 32 23 confirmed confirm VBN cord-258172-p54j4zzo 32 24 by by IN cord-258172-p54j4zzo 32 25 structural structural JJ cord-258172-p54j4zzo 32 26 and and CC cord-258172-p54j4zzo 32 27 biochemical biochemical JJ cord-258172-p54j4zzo 32 28 data datum NNS cord-258172-p54j4zzo 32 29 [ [ -LRB- cord-258172-p54j4zzo 32 30 17 17 CD cord-258172-p54j4zzo 32 31 , , , cord-258172-p54j4zzo 32 32 18 18 CD cord-258172-p54j4zzo 32 33 ] ] -RRB- cord-258172-p54j4zzo 32 34 . . . cord-258172-p54j4zzo 33 1 The the DT cord-258172-p54j4zzo 33 2 clinical clinical JJ cord-258172-p54j4zzo 33 3 characteristics characteristic NNS cord-258172-p54j4zzo 33 4 of of IN cord-258172-p54j4zzo 33 5 COVID-19 covid-19 JJ cord-258172-p54j4zzo 33 6 infection infection NN cord-258172-p54j4zzo 33 7 have have VBP cord-258172-p54j4zzo 33 8 recently recently RB cord-258172-p54j4zzo 33 9 been be VBN cord-258172-p54j4zzo 33 10 described describe VBN cord-258172-p54j4zzo 33 11 based base VBN cord-258172-p54j4zzo 33 12 on on IN cord-258172-p54j4zzo 33 13 data datum NNS cord-258172-p54j4zzo 33 14 from from IN cord-258172-p54j4zzo 33 15 1,099 1,099 CD cord-258172-p54j4zzo 33 16 patients patient NNS cord-258172-p54j4zzo 33 17 from from IN cord-258172-p54j4zzo 33 18 mainland mainland NN cord-258172-p54j4zzo 33 19 China China NNP cord-258172-p54j4zzo 33 20 [ [ -LRB- cord-258172-p54j4zzo 33 21 22 22 CD cord-258172-p54j4zzo 33 22 ] ] -RRB- cord-258172-p54j4zzo 33 23 . . . cord-258172-p54j4zzo 34 1 It -PRON- PRP cord-258172-p54j4zzo 34 2 was be VBD cord-258172-p54j4zzo 34 3 found find VBN cord-258172-p54j4zzo 34 4 that that IN cord-258172-p54j4zzo 34 5 the the DT cord-258172-p54j4zzo 34 6 clinical clinical JJ cord-258172-p54j4zzo 34 7 characteristics characteristic NNS cord-258172-p54j4zzo 34 8 of of IN cord-258172-p54j4zzo 34 9 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 34 10 mimic mimic VBP cord-258172-p54j4zzo 34 11 those those DT cord-258172-p54j4zzo 34 12 of of IN cord-258172-p54j4zzo 34 13 SARS SARS NNP cord-258172-p54j4zzo 34 14 - - HYPH cord-258172-p54j4zzo 34 15 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 34 16 infection infection NN cord-258172-p54j4zzo 34 17 . . . cord-258172-p54j4zzo 35 1 The the DT cord-258172-p54j4zzo 35 2 most most RBS cord-258172-p54j4zzo 35 3 dominant dominant JJ cord-258172-p54j4zzo 35 4 symptoms symptom NNS cord-258172-p54j4zzo 35 5 include include VBP cord-258172-p54j4zzo 35 6 fever fever NN cord-258172-p54j4zzo 35 7 , , , cord-258172-p54j4zzo 35 8 cough cough NN cord-258172-p54j4zzo 35 9 , , , cord-258172-p54j4zzo 35 10 fatigue fatigue NN cord-258172-p54j4zzo 35 11 , , , cord-258172-p54j4zzo 35 12 and and CC cord-258172-p54j4zzo 35 13 sputum sputum NN cord-258172-p54j4zzo 35 14 production production NN cord-258172-p54j4zzo 35 15 , , , cord-258172-p54j4zzo 35 16 whereas whereas IN cord-258172-p54j4zzo 35 17 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 35 18 symptoms symptom NNS cord-258172-p54j4zzo 35 19 are be VBP cord-258172-p54j4zzo 35 20 less less RBR cord-258172-p54j4zzo 35 21 common common JJ cord-258172-p54j4zzo 35 22 . . . cord-258172-p54j4zzo 36 1 In in IN cord-258172-p54j4zzo 36 2 laboratory laboratory NN cord-258172-p54j4zzo 36 3 parameters parameter NNS cord-258172-p54j4zzo 36 4 , , , cord-258172-p54j4zzo 36 5 lymphopenia lymphopenia NNP cord-258172-p54j4zzo 36 6 was be VBD cord-258172-p54j4zzo 36 7 detected detect VBN cord-258172-p54j4zzo 36 8 in in IN cord-258172-p54j4zzo 36 9 83.2 83.2 CD cord-258172-p54j4zzo 36 10 % % NN cord-258172-p54j4zzo 36 11 of of IN cord-258172-p54j4zzo 36 12 patients patient NNS cord-258172-p54j4zzo 36 13 on on IN cord-258172-p54j4zzo 36 14 admission admission NN cord-258172-p54j4zzo 36 15 . . . cord-258172-p54j4zzo 37 1 According accord VBG cord-258172-p54j4zzo 37 2 to to IN cord-258172-p54j4zzo 37 3 another another DT cord-258172-p54j4zzo 37 4 recent recent JJ cord-258172-p54j4zzo 37 5 survey survey NN cord-258172-p54j4zzo 37 6 of of IN cord-258172-p54j4zzo 37 7 278 278 CD cord-258172-p54j4zzo 37 8 patients patient NNS cord-258172-p54j4zzo 37 9 with with IN cord-258172-p54j4zzo 37 10 pneumonia pneumonia NN cord-258172-p54j4zzo 37 11 caused cause VBN cord-258172-p54j4zzo 37 12 by by IN cord-258172-p54j4zzo 37 13 SARS SARS NNP cord-258172-p54j4zzo 37 14 - - HYPH cord-258172-p54j4zzo 37 15 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 37 16 , , , cord-258172-p54j4zzo 37 17 fever fever NN cord-258172-p54j4zzo 37 18 was be VBD cord-258172-p54j4zzo 37 19 the the DT cord-258172-p54j4zzo 37 20 most most RBS cord-258172-p54j4zzo 37 21 common common JJ cord-258172-p54j4zzo 37 22 symptom symptom NN cord-258172-p54j4zzo 37 23 , , , cord-258172-p54j4zzo 37 24 followed follow VBN cord-258172-p54j4zzo 37 25 by by IN cord-258172-p54j4zzo 37 26 cough cough NN cord-258172-p54j4zzo 37 27 [ [ -LRB- cord-258172-p54j4zzo 37 28 23 23 CD cord-258172-p54j4zzo 37 29 ] ] -RRB- cord-258172-p54j4zzo 37 30 . . . cord-258172-p54j4zzo 38 1 Bilateral bilateral JJ cord-258172-p54j4zzo 38 2 pneumonia pneumonia NN cord-258172-p54j4zzo 38 3 has have VBZ cord-258172-p54j4zzo 38 4 been be VBN cord-258172-p54j4zzo 38 5 detected detect VBN cord-258172-p54j4zzo 38 6 by by IN cord-258172-p54j4zzo 38 7 computed compute VBN cord-258172-p54j4zzo 38 8 tomography tomography NN cord-258172-p54j4zzo 38 9 scans scan NNS cord-258172-p54j4zzo 38 10 in in IN cord-258172-p54j4zzo 38 11 67.0 67.0 CD cord-258172-p54j4zzo 38 12 % % NN cord-258172-p54j4zzo 38 13 of of IN cord-258172-p54j4zzo 38 14 patients patient NNS cord-258172-p54j4zzo 38 15 [ [ -LRB- cord-258172-p54j4zzo 38 16 24 24 CD cord-258172-p54j4zzo 38 17 ] ] -RRB- cord-258172-p54j4zzo 38 18 . . . cord-258172-p54j4zzo 39 1 A a DT cord-258172-p54j4zzo 39 2 recent recent JJ cord-258172-p54j4zzo 39 3 study study NN cord-258172-p54j4zzo 39 4 from from IN cord-258172-p54j4zzo 39 5 Wuhan Wuhan NNP cord-258172-p54j4zzo 39 6 , , , cord-258172-p54j4zzo 39 7 China China NNP cord-258172-p54j4zzo 39 8 listed list VBD cord-258172-p54j4zzo 39 9 the the DT cord-258172-p54j4zzo 39 10 most most RBS cord-258172-p54j4zzo 39 11 common common JJ cord-258172-p54j4zzo 39 12 clinical clinical JJ cord-258172-p54j4zzo 39 13 complications complication NNS cord-258172-p54j4zzo 39 14 determined determine VBN cord-258172-p54j4zzo 39 15 in in IN cord-258172-p54j4zzo 39 16 critically critically RB cord-258172-p54j4zzo 39 17 ill ill JJ cord-258172-p54j4zzo 39 18 COVID-19 covid-19 CD cord-258172-p54j4zzo 39 19 patients patient NNS cord-258172-p54j4zzo 39 20 [ [ -LRB- cord-258172-p54j4zzo 39 21 25 25 CD cord-258172-p54j4zzo 39 22 ] ] -RRB- cord-258172-p54j4zzo 39 23 . . . cord-258172-p54j4zzo 40 1 The the DT cord-258172-p54j4zzo 40 2 complications complication NNS cord-258172-p54j4zzo 40 3 during during IN cord-258172-p54j4zzo 40 4 clinical clinical JJ cord-258172-p54j4zzo 40 5 worsening worsen VBG cord-258172-p54j4zzo 40 6 included include VBN cord-258172-p54j4zzo 40 7 acute acute JJ cord-258172-p54j4zzo 40 8 respiratory respiratory JJ cord-258172-p54j4zzo 40 9 distress distress NN cord-258172-p54j4zzo 40 10 syndrome syndrome NN cord-258172-p54j4zzo 40 11 and and CC cord-258172-p54j4zzo 40 12 respiratory respiratory JJ cord-258172-p54j4zzo 40 13 failure failure NN cord-258172-p54j4zzo 40 14 , , , cord-258172-p54j4zzo 40 15 sepsis sepsis NN cord-258172-p54j4zzo 40 16 , , , cord-258172-p54j4zzo 40 17 acute acute JJ cord-258172-p54j4zzo 40 18 cardiac cardiac JJ cord-258172-p54j4zzo 40 19 injury injury NN cord-258172-p54j4zzo 40 20 , , , cord-258172-p54j4zzo 40 21 and and CC cord-258172-p54j4zzo 40 22 heart heart NN cord-258172-p54j4zzo 40 23 failure failure NN cord-258172-p54j4zzo 40 24 . . . cord-258172-p54j4zzo 41 1 Data datum NNS cord-258172-p54j4zzo 41 2 on on IN cord-258172-p54j4zzo 41 3 the the DT cord-258172-p54j4zzo 41 4 localization localization NN cord-258172-p54j4zzo 41 5 of of IN cord-258172-p54j4zzo 41 6 virus virus NN cord-258172-p54j4zzo 41 7 receptors receptor NNS cord-258172-p54j4zzo 41 8 can can MD cord-258172-p54j4zzo 41 9 provide provide VB cord-258172-p54j4zzo 41 10 insight insight NN cord-258172-p54j4zzo 41 11 into into IN cord-258172-p54j4zzo 41 12 mechanisms mechanism NNS cord-258172-p54j4zzo 41 13 of of IN cord-258172-p54j4zzo 41 14 virus virus NN cord-258172-p54j4zzo 41 15 entry entry NN cord-258172-p54j4zzo 41 16 , , , cord-258172-p54j4zzo 41 17 tissue tissue NN cord-258172-p54j4zzo 41 18 tropism tropism NN cord-258172-p54j4zzo 41 19 , , , cord-258172-p54j4zzo 41 20 and and CC cord-258172-p54j4zzo 41 21 pathogenesis pathogenesis NN cord-258172-p54j4zzo 41 22 of of IN cord-258172-p54j4zzo 41 23 the the DT cord-258172-p54j4zzo 41 24 disease disease NN cord-258172-p54j4zzo 41 25 . . . cord-258172-p54j4zzo 42 1 Therefore therefore RB cord-258172-p54j4zzo 42 2 , , , cord-258172-p54j4zzo 42 3 it -PRON- PRP cord-258172-p54j4zzo 42 4 is be VBZ cord-258172-p54j4zzo 42 5 of of IN cord-258172-p54j4zzo 42 6 particular particular JJ cord-258172-p54j4zzo 42 7 interest interest NN cord-258172-p54j4zzo 42 8 to to TO cord-258172-p54j4zzo 42 9 correlate correlate VB cord-258172-p54j4zzo 42 10 COVID-19 covid-19 JJ cord-258172-p54j4zzo 42 11 symptoms symptom NNS cord-258172-p54j4zzo 42 12 with with IN cord-258172-p54j4zzo 42 13 the the DT cord-258172-p54j4zzo 42 14 distribution distribution NN cord-258172-p54j4zzo 42 15 pattern pattern NN cord-258172-p54j4zzo 42 16 of of IN cord-258172-p54j4zzo 42 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 42 18 . . . cord-258172-p54j4zzo 43 1 The the DT cord-258172-p54j4zzo 43 2 first first JJ cord-258172-p54j4zzo 43 3 studies study NNS cord-258172-p54j4zzo 43 4 performed perform VBN cord-258172-p54j4zzo 43 5 by by IN cord-258172-p54j4zzo 43 6 northern northern JJ cord-258172-p54j4zzo 43 7 blotting blotting NN cord-258172-p54j4zzo 43 8 indicated indicate VBD cord-258172-p54j4zzo 43 9 that that IN cord-258172-p54j4zzo 43 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 43 11 is be VBZ cord-258172-p54j4zzo 43 12 located locate VBN cord-258172-p54j4zzo 43 13 in in IN cord-258172-p54j4zzo 43 14 the the DT cord-258172-p54j4zzo 43 15 human human JJ cord-258172-p54j4zzo 43 16 heart heart NN cord-258172-p54j4zzo 43 17 , , , cord-258172-p54j4zzo 43 18 kidney kidney NN cord-258172-p54j4zzo 43 19 , , , cord-258172-p54j4zzo 43 20 and and CC cord-258172-p54j4zzo 43 21 testis testis NN cord-258172-p54j4zzo 43 22 [ [ -LRB- cord-258172-p54j4zzo 43 23 2 2 CD cord-258172-p54j4zzo 43 24 ] ] -RRB- cord-258172-p54j4zzo 43 25 . . . cord-258172-p54j4zzo 44 1 Quantitative quantitative JJ cord-258172-p54j4zzo 44 2 polymerase polymerase NN cord-258172-p54j4zzo 44 3 chain chain NN cord-258172-p54j4zzo 44 4 reaction reaction NN cord-258172-p54j4zzo 44 5 ( ( -LRB- cord-258172-p54j4zzo 44 6 qPCR qPCR NNP cord-258172-p54j4zzo 44 7 ) ) -RRB- cord-258172-p54j4zzo 44 8 showed show VBD cord-258172-p54j4zzo 44 9 the the DT cord-258172-p54j4zzo 44 10 highest high JJS cord-258172-p54j4zzo 44 11 expression expression NN cord-258172-p54j4zzo 44 12 levels level NNS cord-258172-p54j4zzo 44 13 in in IN cord-258172-p54j4zzo 44 14 the the DT cord-258172-p54j4zzo 44 15 human human JJ cord-258172-p54j4zzo 44 16 cardiovascular cardiovascular JJ cord-258172-p54j4zzo 44 17 system system NN cord-258172-p54j4zzo 44 18 , , , cord-258172-p54j4zzo 44 19 testis testis NN cord-258172-p54j4zzo 44 20 , , , cord-258172-p54j4zzo 44 21 kidney kidney NN cord-258172-p54j4zzo 44 22 , , , cord-258172-p54j4zzo 44 23 and and CC cord-258172-p54j4zzo 44 24 intestine intestine NN cord-258172-p54j4zzo 44 25 [ [ -LRB- cord-258172-p54j4zzo 44 26 26 26 CD cord-258172-p54j4zzo 44 27 ] ] -RRB- cord-258172-p54j4zzo 44 28 . . . cord-258172-p54j4zzo 45 1 By by IN cord-258172-p54j4zzo 45 2 immunohistochemistry immunohistochemistry NN cord-258172-p54j4zzo 45 3 , , , cord-258172-p54j4zzo 45 4 the the DT cord-258172-p54j4zzo 45 5 expression expression NN cord-258172-p54j4zzo 45 6 of of IN cord-258172-p54j4zzo 45 7 the the DT cord-258172-p54j4zzo 45 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 45 9 protein protein NN cord-258172-p54j4zzo 45 10 was be VBD cord-258172-p54j4zzo 45 11 identified identify VBN cord-258172-p54j4zzo 45 12 in in IN cord-258172-p54j4zzo 45 13 the the DT cord-258172-p54j4zzo 45 14 human human JJ cord-258172-p54j4zzo 45 15 lung lung NN cord-258172-p54j4zzo 45 16 alveolar alveolar NN cord-258172-p54j4zzo 45 17 epithelial epithelial JJ cord-258172-p54j4zzo 45 18 cells cell NNS cord-258172-p54j4zzo 45 19 ( ( -LRB- cord-258172-p54j4zzo 45 20 type type NN cord-258172-p54j4zzo 45 21 I -PRON- PRP cord-258172-p54j4zzo 45 22 and and CC cord-258172-p54j4zzo 45 23 II II NNP cord-258172-p54j4zzo 45 24 pneumocytes pneumocytes NNPS cord-258172-p54j4zzo 45 25 ) ) -RRB- cord-258172-p54j4zzo 45 26 , , , cord-258172-p54j4zzo 45 27 enterocytes enterocyte NNS cord-258172-p54j4zzo 45 28 of of IN cord-258172-p54j4zzo 45 29 the the DT cord-258172-p54j4zzo 45 30 small small JJ cord-258172-p54j4zzo 45 31 intestine intestine NN cord-258172-p54j4zzo 45 32 , , , cord-258172-p54j4zzo 45 33 the the DT cord-258172-p54j4zzo 45 34 brush brush NN cord-258172-p54j4zzo 45 35 border border NN cord-258172-p54j4zzo 45 36 of of IN cord-258172-p54j4zzo 45 37 the the DT cord-258172-p54j4zzo 45 38 renal renal JJ cord-258172-p54j4zzo 45 39 proximal proximal JJ cord-258172-p54j4zzo 45 40 tubules tubule NNS cord-258172-p54j4zzo 45 41 , , , cord-258172-p54j4zzo 45 42 the the DT cord-258172-p54j4zzo 45 43 endothelial endothelial JJ cord-258172-p54j4zzo 45 44 cells cell NNS cord-258172-p54j4zzo 45 45 of of IN cord-258172-p54j4zzo 45 46 arteries artery NNS cord-258172-p54j4zzo 45 47 and and CC cord-258172-p54j4zzo 45 48 veins vein NNS cord-258172-p54j4zzo 45 49 , , , cord-258172-p54j4zzo 45 50 and and CC cord-258172-p54j4zzo 45 51 arterial arterial JJ cord-258172-p54j4zzo 45 52 smooth smooth JJ cord-258172-p54j4zzo 45 53 muscle muscle NN cord-258172-p54j4zzo 45 54 cells cell NNS cord-258172-p54j4zzo 45 55 in in IN cord-258172-p54j4zzo 45 56 several several JJ cord-258172-p54j4zzo 45 57 organs organ NNS cord-258172-p54j4zzo 45 58 [ [ -LRB- cord-258172-p54j4zzo 45 59 27 27 CD cord-258172-p54j4zzo 45 60 ] ] -RRB- cord-258172-p54j4zzo 45 61 . . . cord-258172-p54j4zzo 46 1 It -PRON- PRP cord-258172-p54j4zzo 46 2 was be VBD cord-258172-p54j4zzo 46 3 proposed propose VBN cord-258172-p54j4zzo 46 4 that that IN cord-258172-p54j4zzo 46 5 this this DT cord-258172-p54j4zzo 46 6 distribution distribution NN cord-258172-p54j4zzo 46 7 pattern pattern NN cord-258172-p54j4zzo 46 8 of of IN cord-258172-p54j4zzo 46 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 46 10 could could MD cord-258172-p54j4zzo 46 11 explain explain VB cord-258172-p54j4zzo 46 12 the the DT cord-258172-p54j4zzo 46 13 tissue tissue NN cord-258172-p54j4zzo 46 14 tropism tropism NN cord-258172-p54j4zzo 46 15 of of IN cord-258172-p54j4zzo 46 16 SARS SARS NNP cord-258172-p54j4zzo 46 17 - - HYPH cord-258172-p54j4zzo 46 18 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 46 19 for for IN cord-258172-p54j4zzo 46 20 the the DT cord-258172-p54j4zzo 46 21 lung lung NN cord-258172-p54j4zzo 46 22 , , , cord-258172-p54j4zzo 46 23 small small JJ cord-258172-p54j4zzo 46 24 intestine intestine NN cord-258172-p54j4zzo 46 25 , , , cord-258172-p54j4zzo 46 26 and and CC cord-258172-p54j4zzo 46 27 kidney kidney NN cord-258172-p54j4zzo 46 28 [ [ -LRB- cord-258172-p54j4zzo 46 29 28 28 CD cord-258172-p54j4zzo 46 30 ] ] -RRB- cord-258172-p54j4zzo 46 31 . . . cord-258172-p54j4zzo 47 1 On on IN cord-258172-p54j4zzo 47 2 the the DT cord-258172-p54j4zzo 47 3 other other JJ cord-258172-p54j4zzo 47 4 hand hand NN cord-258172-p54j4zzo 47 5 , , , cord-258172-p54j4zzo 47 6 the the DT cord-258172-p54j4zzo 47 7 symptoms symptom NNS cord-258172-p54j4zzo 47 8 of of IN cord-258172-p54j4zzo 47 9 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 47 10 , , , cord-258172-p54j4zzo 47 11 in in IN cord-258172-p54j4zzo 47 12 contrast contrast NN cord-258172-p54j4zzo 47 13 to to IN cord-258172-p54j4zzo 47 14 SARS SARS NNP cord-258172-p54j4zzo 47 15 - - HYPH cord-258172-p54j4zzo 47 16 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 47 17 infection infection NN cord-258172-p54j4zzo 47 18 , , , cord-258172-p54j4zzo 47 19 are be VBP cord-258172-p54j4zzo 47 20 not not RB cord-258172-p54j4zzo 47 21 associated associate VBN cord-258172-p54j4zzo 47 22 to to IN cord-258172-p54j4zzo 47 23 the the DT cord-258172-p54j4zzo 47 24 same same JJ cord-258172-p54j4zzo 47 25 extent extent NN cord-258172-p54j4zzo 47 26 with with IN cord-258172-p54j4zzo 47 27 the the DT cord-258172-p54j4zzo 47 28 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 47 29 tract tract NN cord-258172-p54j4zzo 47 30 in in IN cord-258172-p54j4zzo 47 31 spite spite NN cord-258172-p54j4zzo 47 32 of of IN cord-258172-p54j4zzo 47 33 the the DT cord-258172-p54j4zzo 47 34 high high JJ cord-258172-p54j4zzo 47 35 expression expression NN cord-258172-p54j4zzo 47 36 of of IN cord-258172-p54j4zzo 47 37 ACE2 ACE2 NNP cord-258172-p54j4zzo 47 38 in in IN cord-258172-p54j4zzo 47 39 the the DT cord-258172-p54j4zzo 47 40 intestinal intestinal JJ cord-258172-p54j4zzo 47 41 enterocytes enterocyte NNS cord-258172-p54j4zzo 47 42 [ [ -LRB- cord-258172-p54j4zzo 47 43 29 29 CD cord-258172-p54j4zzo 47 44 ] ] -RRB- cord-258172-p54j4zzo 47 45 . . . cord-258172-p54j4zzo 48 1 In in IN cord-258172-p54j4zzo 48 2 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 48 3 , , , cord-258172-p54j4zzo 48 4 diarrhea diarrhea NN cord-258172-p54j4zzo 48 5 has have VBZ cord-258172-p54j4zzo 48 6 been be VBN cord-258172-p54j4zzo 48 7 reported report VBN cord-258172-p54j4zzo 48 8 in in IN cord-258172-p54j4zzo 48 9 just just RB cord-258172-p54j4zzo 48 10 3.8 3.8 CD cord-258172-p54j4zzo 48 11 % % NN cord-258172-p54j4zzo 48 12 of of IN cord-258172-p54j4zzo 48 13 patients patient NNS cord-258172-p54j4zzo 48 14 , , , cord-258172-p54j4zzo 48 15 in in IN cord-258172-p54j4zzo 48 16 contrast contrast NN cord-258172-p54j4zzo 48 17 to to IN cord-258172-p54j4zzo 48 18 40 40 CD cord-258172-p54j4zzo 48 19 - - SYM cord-258172-p54j4zzo 48 20 70 70 CD cord-258172-p54j4zzo 48 21 % % NN cord-258172-p54j4zzo 48 22 in in IN cord-258172-p54j4zzo 48 23 SARS SARS NNP cord-258172-p54j4zzo 48 24 - - HYPH cord-258172-p54j4zzo 48 25 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 48 26 infection infection NN cord-258172-p54j4zzo 48 27 [ [ -LRB- cord-258172-p54j4zzo 48 28 22 22 CD cord-258172-p54j4zzo 48 29 , , , cord-258172-p54j4zzo 48 30 30 30 CD cord-258172-p54j4zzo 48 31 ] ] -RRB- cord-258172-p54j4zzo 48 32 . . . cord-258172-p54j4zzo 49 1 A a DT cord-258172-p54j4zzo 49 2 recent recent JJ cord-258172-p54j4zzo 49 3 report report NN cord-258172-p54j4zzo 49 4 indicated indicate VBD cord-258172-p54j4zzo 49 5 diarrhea diarrhea NN cord-258172-p54j4zzo 49 6 in in IN cord-258172-p54j4zzo 49 7 18.1 18.1 CD cord-258172-p54j4zzo 49 8 % % NN cord-258172-p54j4zzo 49 9 of of IN cord-258172-p54j4zzo 49 10 254 254 CD cord-258172-p54j4zzo 49 11 COVID-19 covid-19 CD cord-258172-p54j4zzo 49 12 patients patient NNS cord-258172-p54j4zzo 49 13 [ [ -LRB- cord-258172-p54j4zzo 49 14 31 31 CD cord-258172-p54j4zzo 49 15 ] ] -RRB- cord-258172-p54j4zzo 49 16 . . . cord-258172-p54j4zzo 50 1 There there EX cord-258172-p54j4zzo 50 2 are be VBP cord-258172-p54j4zzo 50 3 conflicting conflict VBG cord-258172-p54j4zzo 50 4 reports report NNS cord-258172-p54j4zzo 50 5 on on IN cord-258172-p54j4zzo 50 6 the the DT cord-258172-p54j4zzo 50 7 expression expression NN cord-258172-p54j4zzo 50 8 of of IN cord-258172-p54j4zzo 50 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 50 10 in in IN cord-258172-p54j4zzo 50 11 the the DT cord-258172-p54j4zzo 50 12 upper upper JJ cord-258172-p54j4zzo 50 13 respiratory respiratory JJ cord-258172-p54j4zzo 50 14 tract tract NN cord-258172-p54j4zzo 50 15 [ [ -LRB- cord-258172-p54j4zzo 50 16 30 30 CD cord-258172-p54j4zzo 50 17 ] ] -RRB- cord-258172-p54j4zzo 50 18 . . . cord-258172-p54j4zzo 51 1 Hamming hamming NN cord-258172-p54j4zzo 51 2 and and CC cord-258172-p54j4zzo 51 3 coworkers coworker NNS cord-258172-p54j4zzo 51 4 found find VBD cord-258172-p54j4zzo 51 5 that that IN cord-258172-p54j4zzo 51 6 only only RB cord-258172-p54j4zzo 51 7 the the DT cord-258172-p54j4zzo 51 8 basal basal NN cord-258172-p54j4zzo 51 9 layer layer NN cord-258172-p54j4zzo 51 10 of of IN cord-258172-p54j4zzo 51 11 nonkeratinized nonkeratinize VBN cord-258172-p54j4zzo 51 12 airway airway NN cord-258172-p54j4zzo 51 13 squamous squamous JJ cord-258172-p54j4zzo 51 14 epithelium epithelium NN cord-258172-p54j4zzo 51 15 shows show VBZ cord-258172-p54j4zzo 51 16 positive positive JJ cord-258172-p54j4zzo 51 17 signal signal NN cord-258172-p54j4zzo 51 18 [ [ -LRB- cord-258172-p54j4zzo 51 19 27 27 CD cord-258172-p54j4zzo 51 20 ] ] -RRB- cord-258172-p54j4zzo 51 21 , , , cord-258172-p54j4zzo 51 22 whereas whereas IN cord-258172-p54j4zzo 51 23 Sims sim NNS cord-258172-p54j4zzo 51 24 and and CC cord-258172-p54j4zzo 51 25 colleagues colleague NNS cord-258172-p54j4zzo 51 26 demonstrated demonstrate VBD cord-258172-p54j4zzo 51 27 ACE2 ACE2 NNP cord-258172-p54j4zzo 51 28 expression expression NN cord-258172-p54j4zzo 51 29 on on IN cord-258172-p54j4zzo 51 30 the the DT cord-258172-p54j4zzo 51 31 luminal luminal JJ cord-258172-p54j4zzo 51 32 surface surface NN cord-258172-p54j4zzo 51 33 of of IN cord-258172-p54j4zzo 51 34 ciliated ciliated JJ cord-258172-p54j4zzo 51 35 cells cell NNS cord-258172-p54j4zzo 51 36 in in IN cord-258172-p54j4zzo 51 37 freshly freshly RB cord-258172-p54j4zzo 51 38 excised excise VBN cord-258172-p54j4zzo 51 39 human human JJ cord-258172-p54j4zzo 51 40 nasal nasal NN cord-258172-p54j4zzo 51 41 and and CC cord-258172-p54j4zzo 51 42 tracheobronchial tracheobronchial JJ cord-258172-p54j4zzo 51 43 tissue tissue NN cord-258172-p54j4zzo 51 44 [ [ -LRB- cord-258172-p54j4zzo 51 45 32 32 CD cord-258172-p54j4zzo 51 46 ] ] -RRB- cord-258172-p54j4zzo 51 47 . . . cord-258172-p54j4zzo 52 1 Ren Ren NNP cord-258172-p54j4zzo 52 2 and and CC cord-258172-p54j4zzo 52 3 coworkers coworker NNS cord-258172-p54j4zzo 52 4 showed show VBD cord-258172-p54j4zzo 52 5 weak weak JJ cord-258172-p54j4zzo 52 6 ACE2-positive ace2-positive JJ cord-258172-p54j4zzo 52 7 signal signal NN cord-258172-p54j4zzo 52 8 in in IN cord-258172-p54j4zzo 52 9 the the DT cord-258172-p54j4zzo 52 10 epithelial epithelial JJ cord-258172-p54j4zzo 52 11 cells cell NNS cord-258172-p54j4zzo 52 12 of of IN cord-258172-p54j4zzo 52 13 trachea trachea NN cord-258172-p54j4zzo 52 14 and and CC cord-258172-p54j4zzo 52 15 main main JJ cord-258172-p54j4zzo 52 16 bronchus bronchus NN cord-258172-p54j4zzo 52 17 [ [ -LRB- cord-258172-p54j4zzo 52 18 33 33 CD cord-258172-p54j4zzo 52 19 ] ] -RRB- cord-258172-p54j4zzo 52 20 . . . cord-258172-p54j4zzo 53 1 Although although IN cord-258172-p54j4zzo 53 2 lymphopenia lymphopenia NNP cord-258172-p54j4zzo 53 3 is be VBZ cord-258172-p54j4zzo 53 4 a a DT cord-258172-p54j4zzo 53 5 typical typical JJ cord-258172-p54j4zzo 53 6 feature feature NN cord-258172-p54j4zzo 53 7 of of IN cord-258172-p54j4zzo 53 8 SARS SARS NNP cord-258172-p54j4zzo 53 9 [ [ -LRB- cord-258172-p54j4zzo 53 10 22 22 CD cord-258172-p54j4zzo 53 11 , , , cord-258172-p54j4zzo 53 12 30 30 CD cord-258172-p54j4zzo 53 13 ] ] -RRB- cord-258172-p54j4zzo 53 14 , , , cord-258172-p54j4zzo 53 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 53 16 is be VBZ cord-258172-p54j4zzo 53 17 not not RB cord-258172-p54j4zzo 53 18 highly highly RB cord-258172-p54j4zzo 53 19 expressed express VBN cord-258172-p54j4zzo 53 20 on on IN cord-258172-p54j4zzo 53 21 T T NNP cord-258172-p54j4zzo 53 22 or or CC cord-258172-p54j4zzo 53 23 B b NN cord-258172-p54j4zzo 53 24 cells cell NNS cord-258172-p54j4zzo 53 25 or or CC cord-258172-p54j4zzo 53 26 macrophages macrophage NNS cord-258172-p54j4zzo 53 27 in in IN cord-258172-p54j4zzo 53 28 the the DT cord-258172-p54j4zzo 53 29 spleen spleen NN cord-258172-p54j4zzo 53 30 or or CC cord-258172-p54j4zzo 53 31 lymphoid lymphoid JJ cord-258172-p54j4zzo 53 32 organs organ NNS cord-258172-p54j4zzo 53 33 [ [ -LRB- cord-258172-p54j4zzo 53 34 27 27 CD cord-258172-p54j4zzo 53 35 ] ] -RRB- cord-258172-p54j4zzo 53 36 . . . cord-258172-p54j4zzo 54 1 It -PRON- PRP cord-258172-p54j4zzo 54 2 is be VBZ cord-258172-p54j4zzo 54 3 known know VBN cord-258172-p54j4zzo 54 4 that that IN cord-258172-p54j4zzo 54 5 both both DT cord-258172-p54j4zzo 54 6 SARS SARS NNP cord-258172-p54j4zzo 54 7 - - HYPH cord-258172-p54j4zzo 54 8 CoV CoV NNP cord-258172-p54j4zzo 54 9 and and CC cord-258172-p54j4zzo 54 10 SARS SARS NNP cord-258172-p54j4zzo 54 11 - - HYPH cord-258172-p54j4zzo 54 12 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 54 13 infections infection NNS cord-258172-p54j4zzo 54 14 lead lead VBP cord-258172-p54j4zzo 54 15 to to IN cord-258172-p54j4zzo 54 16 worse bad JJR cord-258172-p54j4zzo 54 17 outcome outcome NN cord-258172-p54j4zzo 54 18 in in IN cord-258172-p54j4zzo 54 19 the the DT cord-258172-p54j4zzo 54 20 elderly elderly JJ cord-258172-p54j4zzo 54 21 [ [ -LRB- cord-258172-p54j4zzo 54 22 30 30 CD cord-258172-p54j4zzo 54 23 , , , cord-258172-p54j4zzo 54 24 34 34 CD cord-258172-p54j4zzo 54 25 ] ] -RRB- cord-258172-p54j4zzo 54 26 . . . cord-258172-p54j4zzo 55 1 Recent recent JJ cord-258172-p54j4zzo 55 2 studies study NNS cord-258172-p54j4zzo 55 3 have have VBP cord-258172-p54j4zzo 55 4 also also RB cord-258172-p54j4zzo 55 5 indicated indicate VBN cord-258172-p54j4zzo 55 6 higher high JJR cord-258172-p54j4zzo 55 7 case case NN cord-258172-p54j4zzo 55 8 fatality fatality NN cord-258172-p54j4zzo 55 9 rates rate NNS cord-258172-p54j4zzo 55 10 in in IN cord-258172-p54j4zzo 55 11 males male NNS cord-258172-p54j4zzo 55 12 than than IN cord-258172-p54j4zzo 55 13 females female NNS cord-258172-p54j4zzo 55 14 [ [ -LRB- cord-258172-p54j4zzo 55 15 35 35 CD cord-258172-p54j4zzo 55 16 ] ] -RRB- cord-258172-p54j4zzo 55 17 . . . cord-258172-p54j4zzo 56 1 Therefore therefore RB cord-258172-p54j4zzo 56 2 , , , cord-258172-p54j4zzo 56 3 one one CD cord-258172-p54j4zzo 56 4 aim aim NN cord-258172-p54j4zzo 56 5 of of IN cord-258172-p54j4zzo 56 6 the the DT cord-258172-p54j4zzo 56 7 present present JJ cord-258172-p54j4zzo 56 8 study study NN cord-258172-p54j4zzo 56 9 was be VBD cord-258172-p54j4zzo 56 10 to to TO cord-258172-p54j4zzo 56 11 investigate investigate VB cord-258172-p54j4zzo 56 12 whether whether IN cord-258172-p54j4zzo 56 13 age age NN cord-258172-p54j4zzo 56 14 or or CC cord-258172-p54j4zzo 56 15 gender gender NN cord-258172-p54j4zzo 56 16 could could MD cord-258172-p54j4zzo 56 17 contribute contribute VB cord-258172-p54j4zzo 56 18 to to IN cord-258172-p54j4zzo 56 19 the the DT cord-258172-p54j4zzo 56 20 regulation regulation NN cord-258172-p54j4zzo 56 21 of of IN cord-258172-p54j4zzo 56 22 ACE2 ACE2 NNP cord-258172-p54j4zzo 56 23 expression expression NN cord-258172-p54j4zzo 56 24 . . . cord-258172-p54j4zzo 57 1 We -PRON- PRP cord-258172-p54j4zzo 57 2 also also RB cord-258172-p54j4zzo 57 3 decided decide VBD cord-258172-p54j4zzo 57 4 to to TO cord-258172-p54j4zzo 57 5 explore explore VB cord-258172-p54j4zzo 57 6 the the DT cord-258172-p54j4zzo 57 7 transcriptional transcriptional JJ cord-258172-p54j4zzo 57 8 regulation regulation NN cord-258172-p54j4zzo 57 9 of of IN cord-258172-p54j4zzo 57 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 57 11 gene gene NN cord-258172-p54j4zzo 57 12 expression expression NN cord-258172-p54j4zzo 57 13 using use VBG cord-258172-p54j4zzo 57 14 a a DT cord-258172-p54j4zzo 57 15 novel novel JJ cord-258172-p54j4zzo 57 16 computational computational JJ cord-258172-p54j4zzo 57 17 tool tool NN cord-258172-p54j4zzo 57 18 recently recently RB cord-258172-p54j4zzo 57 19 developed develop VBN cord-258172-p54j4zzo 57 20 by by IN cord-258172-p54j4zzo 57 21 the the DT cord-258172-p54j4zzo 57 22 first first JJ cord-258172-p54j4zzo 57 23 author author NN cord-258172-p54j4zzo 57 24 of of IN cord-258172-p54j4zzo 57 25 this this DT cord-258172-p54j4zzo 57 26 article article NN cord-258172-p54j4zzo 57 27 . . . cord-258172-p54j4zzo 58 1 Notably notably RB cord-258172-p54j4zzo 58 2 , , , cord-258172-p54j4zzo 58 3 data datum NNS cord-258172-p54j4zzo 58 4 on on IN cord-258172-p54j4zzo 58 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 58 6 distribution distribution NN cord-258172-p54j4zzo 58 7 is be VBZ cord-258172-p54j4zzo 58 8 still still RB cord-258172-p54j4zzo 58 9 conflicting conflict VBG cord-258172-p54j4zzo 58 10 , , , cord-258172-p54j4zzo 58 11 and and CC cord-258172-p54j4zzo 58 12 thus thus RB cord-258172-p54j4zzo 58 13 we -PRON- PRP cord-258172-p54j4zzo 58 14 aimed aim VBD cord-258172-p54j4zzo 58 15 to to TO cord-258172-p54j4zzo 58 16 get get VB cord-258172-p54j4zzo 58 17 a a DT cord-258172-p54j4zzo 58 18 more more RBR cord-258172-p54j4zzo 58 19 comprehensive comprehensive JJ cord-258172-p54j4zzo 58 20 view view NN cord-258172-p54j4zzo 58 21 of of IN cord-258172-p54j4zzo 58 22 the the DT cord-258172-p54j4zzo 58 23 cell cell NN cord-258172-p54j4zzo 58 24 types type NNS cord-258172-p54j4zzo 58 25 expressing express VBG cord-258172-p54j4zzo 58 26 the the DT cord-258172-p54j4zzo 58 27 receptor receptor NN cord-258172-p54j4zzo 58 28 of of IN cord-258172-p54j4zzo 58 29 SARS SARS NNP cord-258172-p54j4zzo 58 30 - - HYPH cord-258172-p54j4zzo 58 31 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 58 32 . . . cord-258172-p54j4zzo 59 1 Finally finally RB cord-258172-p54j4zzo 59 2 , , , cord-258172-p54j4zzo 59 3 we -PRON- PRP cord-258172-p54j4zzo 59 4 studied study VBD cord-258172-p54j4zzo 59 5 the the DT cord-258172-p54j4zzo 59 6 coexpression coexpression NN cord-258172-p54j4zzo 59 7 of of IN cord-258172-p54j4zzo 59 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 59 9 with with IN cord-258172-p54j4zzo 59 10 other other JJ cord-258172-p54j4zzo 59 11 genes gene NNS cord-258172-p54j4zzo 59 12 and and CC cord-258172-p54j4zzo 59 13 explored explore VBD cord-258172-p54j4zzo 59 14 its -PRON- PRP$ cord-258172-p54j4zzo 59 15 putative putative JJ cord-258172-p54j4zzo 59 16 functions function NNS cord-258172-p54j4zzo 59 17 using use VBG cord-258172-p54j4zzo 59 18 a a DT cord-258172-p54j4zzo 59 19 gene gene NN cord-258172-p54j4zzo 59 20 ontology ontology NN cord-258172-p54j4zzo 59 21 enrichment enrichment NN cord-258172-p54j4zzo 59 22 analysis analysis NN cord-258172-p54j4zzo 59 23 . . . cord-258172-p54j4zzo 60 1 From from IN cord-258172-p54j4zzo 60 2 the the DT cord-258172-p54j4zzo 60 3 FANTOM5 fantom5 NN cord-258172-p54j4zzo 60 4 project project NN cord-258172-p54j4zzo 60 5 [ [ -LRB- cord-258172-p54j4zzo 60 6 36 36 CD cord-258172-p54j4zzo 60 7 ] ] -RRB- cord-258172-p54j4zzo 60 8 , , , cord-258172-p54j4zzo 60 9 cap cap NN cord-258172-p54j4zzo 60 10 analysis analysis NN cord-258172-p54j4zzo 60 11 of of IN cord-258172-p54j4zzo 60 12 gene gene NN cord-258172-p54j4zzo 60 13 expression expression NN cord-258172-p54j4zzo 60 14 ( ( -LRB- cord-258172-p54j4zzo 60 15 CAGE cage NN cord-258172-p54j4zzo 60 16 ) ) -RRB- cord-258172-p54j4zzo 60 17 sequencing sequencing NN cord-258172-p54j4zzo 60 18 of of IN cord-258172-p54j4zzo 60 19 cDNA cdna NN cord-258172-p54j4zzo 60 20 has have VBZ cord-258172-p54j4zzo 60 21 been be VBN cord-258172-p54j4zzo 60 22 performed perform VBN cord-258172-p54j4zzo 60 23 in in IN cord-258172-p54j4zzo 60 24 1,839 1,839 CD cord-258172-p54j4zzo 60 25 human human JJ cord-258172-p54j4zzo 60 26 samples sample NNS cord-258172-p54j4zzo 60 27 from from IN cord-258172-p54j4zzo 60 28 875 875 CD cord-258172-p54j4zzo 60 29 different different JJ cord-258172-p54j4zzo 60 30 primary primary JJ cord-258172-p54j4zzo 60 31 cells cell NNS cord-258172-p54j4zzo 60 32 , , , cord-258172-p54j4zzo 60 33 tissues tissue NNS cord-258172-p54j4zzo 60 34 , , , cord-258172-p54j4zzo 60 35 and and CC cord-258172-p54j4zzo 60 36 cell cell NN cord-258172-p54j4zzo 60 37 lines line NNS cord-258172-p54j4zzo 60 38 ( ( -LRB- cord-258172-p54j4zzo 60 39 description description NN cord-258172-p54j4zzo 60 40 of of IN cord-258172-p54j4zzo 60 41 all all DT cord-258172-p54j4zzo 60 42 public public JJ cord-258172-p54j4zzo 60 43 datasets dataset NNS cord-258172-p54j4zzo 60 44 used use VBN cord-258172-p54j4zzo 60 45 presented present VBN cord-258172-p54j4zzo 60 46 as as IN cord-258172-p54j4zzo 60 47 S1 S1 NNP cord-258172-p54j4zzo 60 48 Table Table NNP cord-258172-p54j4zzo 60 49 ) ) -RRB- cord-258172-p54j4zzo 60 50 . . . cord-258172-p54j4zzo 61 1 Expression expression NN cord-258172-p54j4zzo 61 2 of of IN cord-258172-p54j4zzo 61 3 transcription transcription NN cord-258172-p54j4zzo 61 4 start start NN cord-258172-p54j4zzo 61 5 sites site NNS cord-258172-p54j4zzo 61 6 ( ( -LRB- cord-258172-p54j4zzo 61 7 TSSs TSSs NNP cord-258172-p54j4zzo 61 8 ) ) -RRB- cord-258172-p54j4zzo 61 9 was be VBD cord-258172-p54j4zzo 61 10 extracted extract VBN cord-258172-p54j4zzo 61 11 and and CC cord-258172-p54j4zzo 61 12 combined combine VBN cord-258172-p54j4zzo 61 13 for for IN cord-258172-p54j4zzo 61 14 all all DT cord-258172-p54j4zzo 61 15 genes gene NNS cord-258172-p54j4zzo 61 16 in in IN cord-258172-p54j4zzo 61 17 all all DT cord-258172-p54j4zzo 61 18 samples sample NNS cord-258172-p54j4zzo 61 19 as as IN cord-258172-p54j4zzo 61 20 tags tag NNS cord-258172-p54j4zzo 61 21 per per IN cord-258172-p54j4zzo 61 22 million million CD cord-258172-p54j4zzo 61 23 ( ( -LRB- cord-258172-p54j4zzo 61 24 TPM TPM NNP cord-258172-p54j4zzo 61 25 ) ) -RRB- cord-258172-p54j4zzo 61 26 . . . cord-258172-p54j4zzo 62 1 From from IN cord-258172-p54j4zzo 62 2 this this DT cord-258172-p54j4zzo 62 3 compiled compile VBN cord-258172-p54j4zzo 62 4 set set NN cord-258172-p54j4zzo 62 5 , , , cord-258172-p54j4zzo 62 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 62 7 gene gene NN cord-258172-p54j4zzo 62 8 expression expression NN cord-258172-p54j4zzo 62 9 was be VBD cord-258172-p54j4zzo 62 10 extracted extract VBN cord-258172-p54j4zzo 62 11 and and CC cord-258172-p54j4zzo 62 12 presented present VBN cord-258172-p54j4zzo 62 13 as as IN cord-258172-p54j4zzo 62 14 barplot barplot NNP cord-258172-p54j4zzo 62 15 using use VBG cord-258172-p54j4zzo 62 16 the the DT cord-258172-p54j4zzo 62 17 Matplotlib Matplotlib NNPS cord-258172-p54j4zzo 62 18 [ [ -LRB- cord-258172-p54j4zzo 62 19 37 37 CD cord-258172-p54j4zzo 62 20 ] ] -RRB- cord-258172-p54j4zzo 62 21 and and CC cord-258172-p54j4zzo 62 22 Seaborn Seaborn NNP cord-258172-p54j4zzo 62 23 [ [ -LRB- cord-258172-p54j4zzo 62 24 38 38 CD cord-258172-p54j4zzo 62 25 ] ] -RRB- cord-258172-p54j4zzo 62 26 Python Python NNP cord-258172-p54j4zzo 62 27 libraries library NNS cord-258172-p54j4zzo 62 28 . . . cord-258172-p54j4zzo 63 1 Similarly similarly RB cord-258172-p54j4zzo 63 2 , , , cord-258172-p54j4zzo 63 3 human human JJ cord-258172-p54j4zzo 63 4 gene gene NN cord-258172-p54j4zzo 63 5 expression expression NN cord-258172-p54j4zzo 63 6 data datum NNS cord-258172-p54j4zzo 63 7 ( ( -LRB- cord-258172-p54j4zzo 63 8 as as IN cord-258172-p54j4zzo 63 9 TPM TPM NNP cord-258172-p54j4zzo 63 10 ) ) -RRB- cord-258172-p54j4zzo 63 11 was be VBD cord-258172-p54j4zzo 63 12 extracted extract VBN cord-258172-p54j4zzo 63 13 from from IN cord-258172-p54j4zzo 63 14 the the DT cord-258172-p54j4zzo 63 15 GTEx gtex NN cord-258172-p54j4zzo 63 16 database database NN cord-258172-p54j4zzo 63 17 , , , cord-258172-p54j4zzo 63 18 which which WDT cord-258172-p54j4zzo 63 19 is be VBZ cord-258172-p54j4zzo 63 20 an an DT cord-258172-p54j4zzo 63 21 ongoing ongoing JJ cord-258172-p54j4zzo 63 22 largescale largescale JJ cord-258172-p54j4zzo 63 23 project project NN cord-258172-p54j4zzo 63 24 to to TO cord-258172-p54j4zzo 63 25 identify identify VB cord-258172-p54j4zzo 63 26 human human JJ cord-258172-p54j4zzo 63 27 variation variation NN cord-258172-p54j4zzo 63 28 , , , cord-258172-p54j4zzo 63 29 regulation regulation NN cord-258172-p54j4zzo 63 30 , , , cord-258172-p54j4zzo 63 31 and and CC cord-258172-p54j4zzo 63 32 gene gene NN cord-258172-p54j4zzo 63 33 expression expression NN cord-258172-p54j4zzo 63 34 [ [ -LRB- cord-258172-p54j4zzo 63 35 39 39 CD cord-258172-p54j4zzo 63 36 ] ] -RRB- cord-258172-p54j4zzo 63 37 , , , cord-258172-p54j4zzo 63 38 along along IN cord-258172-p54j4zzo 63 39 with with IN cord-258172-p54j4zzo 63 40 metadata metadata NN cord-258172-p54j4zzo 63 41 on on IN cord-258172-p54j4zzo 63 42 the the DT cord-258172-p54j4zzo 63 43 samples sample NNS cord-258172-p54j4zzo 63 44 . . . cord-258172-p54j4zzo 64 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 64 2 gene gene NN cord-258172-p54j4zzo 64 3 expression expression NN cord-258172-p54j4zzo 64 4 values value NNS cord-258172-p54j4zzo 64 5 were be VBD cord-258172-p54j4zzo 64 6 separated separate VBN cord-258172-p54j4zzo 64 7 by by IN cord-258172-p54j4zzo 64 8 tissue tissue NN cord-258172-p54j4zzo 64 9 and and CC cord-258172-p54j4zzo 64 10 compared compare VBN cord-258172-p54j4zzo 64 11 among among IN cord-258172-p54j4zzo 64 12 10-year 10-year CD cord-258172-p54j4zzo 64 13 interval interval NN cord-258172-p54j4zzo 64 14 age age NN cord-258172-p54j4zzo 64 15 groups group NNS cord-258172-p54j4zzo 64 16 to to TO cord-258172-p54j4zzo 64 17 determine determine VB cord-258172-p54j4zzo 64 18 if if IN cord-258172-p54j4zzo 64 19 the the DT cord-258172-p54j4zzo 64 20 values value NNS cord-258172-p54j4zzo 64 21 showed show VBD cord-258172-p54j4zzo 64 22 any any DT cord-258172-p54j4zzo 64 23 differences difference NNS cord-258172-p54j4zzo 64 24 throughout throughout IN cord-258172-p54j4zzo 64 25 the the DT cord-258172-p54j4zzo 64 26 lifecycle lifecycle NN cord-258172-p54j4zzo 64 27 . . . cord-258172-p54j4zzo 65 1 Boxplots boxplot NNS cord-258172-p54j4zzo 65 2 for for IN cord-258172-p54j4zzo 65 3 tissues tissue NNS cord-258172-p54j4zzo 65 4 of of IN cord-258172-p54j4zzo 65 5 relevance relevance NN cord-258172-p54j4zzo 65 6 were be VBD cord-258172-p54j4zzo 65 7 generated generate VBN cord-258172-p54j4zzo 65 8 using use VBG cord-258172-p54j4zzo 65 9 Matplotlib Matplotlib NNP cord-258172-p54j4zzo 65 10 and and CC cord-258172-p54j4zzo 65 11 Seaborn Seaborn NNP cord-258172-p54j4zzo 65 12 libraries library NNS cord-258172-p54j4zzo 65 13 . . . cord-258172-p54j4zzo 66 1 In in IN cord-258172-p54j4zzo 66 2 each each DT cord-258172-p54j4zzo 66 3 of of IN cord-258172-p54j4zzo 66 4 the the DT cord-258172-p54j4zzo 66 5 tissues tissue NNS cord-258172-p54j4zzo 66 6 present present JJ cord-258172-p54j4zzo 66 7 in in IN cord-258172-p54j4zzo 66 8 the the DT cord-258172-p54j4zzo 66 9 GTEx gtex NN cord-258172-p54j4zzo 66 10 dataset dataset NN cord-258172-p54j4zzo 66 11 , , , cord-258172-p54j4zzo 66 12 expression expression NN cord-258172-p54j4zzo 66 13 values value NNS cord-258172-p54j4zzo 66 14 for for IN cord-258172-p54j4zzo 66 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 66 16 were be VBD cord-258172-p54j4zzo 66 17 compared compare VBN cord-258172-p54j4zzo 66 18 with with IN cord-258172-p54j4zzo 66 19 expression expression NN cord-258172-p54j4zzo 66 20 of of IN cord-258172-p54j4zzo 66 21 all all DT cord-258172-p54j4zzo 66 22 other other JJ cord-258172-p54j4zzo 66 23 genes gene NNS cord-258172-p54j4zzo 66 24 by by IN cord-258172-p54j4zzo 66 25 Spearman Spearman NNP cord-258172-p54j4zzo 66 26 correlation correlation NN cord-258172-p54j4zzo 66 27 analysis analysis NN cord-258172-p54j4zzo 66 28 using use VBG cord-258172-p54j4zzo 66 29 the the DT cord-258172-p54j4zzo 66 30 SciPy SciPy NNP cord-258172-p54j4zzo 66 31 [ [ -LRB- cord-258172-p54j4zzo 66 32 40 40 CD cord-258172-p54j4zzo 66 33 ] ] -RRB- cord-258172-p54j4zzo 66 34 Python Python NNP cord-258172-p54j4zzo 66 35 library library NN cord-258172-p54j4zzo 66 36 to to TO cord-258172-p54j4zzo 66 37 identify identify VB cord-258172-p54j4zzo 66 38 those those DT cord-258172-p54j4zzo 66 39 genes gene NNS cord-258172-p54j4zzo 66 40 with with IN cord-258172-p54j4zzo 66 41 concordant concordant JJ cord-258172-p54j4zzo 66 42 expression expression NN cord-258172-p54j4zzo 66 43 patterns pattern NNS cord-258172-p54j4zzo 66 44 . . . cord-258172-p54j4zzo 67 1 Bonferroni bonferroni JJ cord-258172-p54j4zzo 67 2 correction correction NN cord-258172-p54j4zzo 67 3 was be VBD cord-258172-p54j4zzo 67 4 used use VBN cord-258172-p54j4zzo 67 5 to to TO cord-258172-p54j4zzo 67 6 derive derive VB cord-258172-p54j4zzo 67 7 an an DT cord-258172-p54j4zzo 67 8 adjusted adjust VBN cord-258172-p54j4zzo 67 9 p p NN cord-258172-p54j4zzo 67 10 - - HYPH cord-258172-p54j4zzo 67 11 value value NN cord-258172-p54j4zzo 67 12 threshold threshold NN cord-258172-p54j4zzo 67 13 of of IN cord-258172-p54j4zzo 67 14 9.158E-07 9.158e-07 CD cord-258172-p54j4zzo 67 15 . . . cord-258172-p54j4zzo 68 1 For for IN cord-258172-p54j4zzo 68 2 each each DT cord-258172-p54j4zzo 68 3 tissue tissue NN cord-258172-p54j4zzo 68 4 , , , cord-258172-p54j4zzo 68 5 those those DT cord-258172-p54j4zzo 68 6 genes gene NNS cord-258172-p54j4zzo 68 7 which which WDT cord-258172-p54j4zzo 68 8 both both DT cord-258172-p54j4zzo 68 9 satisfied satisfy VBD cord-258172-p54j4zzo 68 10 the the DT cord-258172-p54j4zzo 68 11 Bonferroni Bonferroni NNP cord-258172-p54j4zzo 68 12 - - HYPH cord-258172-p54j4zzo 68 13 adjusted adjust VBN cord-258172-p54j4zzo 68 14 p p NN cord-258172-p54j4zzo 68 15 - - HYPH cord-258172-p54j4zzo 68 16 value value NN cord-258172-p54j4zzo 68 17 threshold threshold NN cord-258172-p54j4zzo 68 18 and and CC cord-258172-p54j4zzo 68 19 had have VBD cord-258172-p54j4zzo 68 20 a a DT cord-258172-p54j4zzo 68 21 correlation correlation NN cord-258172-p54j4zzo 68 22 of of IN cord-258172-p54j4zzo 68 23 expression expression NN cord-258172-p54j4zzo 68 24 of of IN cord-258172-p54j4zzo 68 25 0.50 0.50 CD cord-258172-p54j4zzo 68 26 or or CC cord-258172-p54j4zzo 68 27 greater great JJR cord-258172-p54j4zzo 68 28 were be VBD cord-258172-p54j4zzo 68 29 analyzed analyze VBN cord-258172-p54j4zzo 68 30 using use VBG cord-258172-p54j4zzo 68 31 the the DT cord-258172-p54j4zzo 68 32 Gprofiler Gprofiler NNP cord-258172-p54j4zzo 68 33 gene gene NN cord-258172-p54j4zzo 68 34 ontology ontology NN cord-258172-p54j4zzo 68 35 ( ( -LRB- cord-258172-p54j4zzo 68 36 GO GO NNP cord-258172-p54j4zzo 68 37 ) ) -RRB- cord-258172-p54j4zzo 68 38 enrichment enrichment NN cord-258172-p54j4zzo 68 39 analysis analysis NN cord-258172-p54j4zzo 68 40 [ [ -LRB- cord-258172-p54j4zzo 68 41 41 41 CD cord-258172-p54j4zzo 68 42 ] ] -RRB- cord-258172-p54j4zzo 68 43 Python Python NNP cord-258172-p54j4zzo 68 44 library library NN cord-258172-p54j4zzo 68 45 to to TO cord-258172-p54j4zzo 68 46 identify identify VB cord-258172-p54j4zzo 68 47 possible possible JJ cord-258172-p54j4zzo 68 48 enriched enriched JJ cord-258172-p54j4zzo 68 49 terms term NNS cord-258172-p54j4zzo 68 50 in in IN cord-258172-p54j4zzo 68 51 biological biological JJ cord-258172-p54j4zzo 68 52 process process NN cord-258172-p54j4zzo 68 53 ( ( -LRB- cord-258172-p54j4zzo 68 54 BP BP NNP cord-258172-p54j4zzo 68 55 ) ) -RRB- cord-258172-p54j4zzo 68 56 , , , cord-258172-p54j4zzo 68 57 molecular molecular JJ cord-258172-p54j4zzo 68 58 function function NN cord-258172-p54j4zzo 68 59 ( ( -LRB- cord-258172-p54j4zzo 68 60 MF MF NNP cord-258172-p54j4zzo 68 61 ) ) -RRB- cord-258172-p54j4zzo 68 62 , , , cord-258172-p54j4zzo 68 63 cellular cellular JJ cord-258172-p54j4zzo 68 64 component component NN cord-258172-p54j4zzo 68 65 ( ( -LRB- cord-258172-p54j4zzo 68 66 CC CC NNP cord-258172-p54j4zzo 68 67 ) ) -RRB- cord-258172-p54j4zzo 68 68 , , , cord-258172-p54j4zzo 68 69 human human JJ cord-258172-p54j4zzo 68 70 phenotype phenotype NN cord-258172-p54j4zzo 68 71 ( ( -LRB- cord-258172-p54j4zzo 68 72 HP HP NNP cord-258172-p54j4zzo 68 73 ) ) -RRB- cord-258172-p54j4zzo 68 74 , , , cord-258172-p54j4zzo 68 75 KEGG KEGG NNP cord-258172-p54j4zzo 68 76 pathway pathway NN cord-258172-p54j4zzo 68 77 , , , cord-258172-p54j4zzo 68 78 and and CC cord-258172-p54j4zzo 68 79 WikiPathways WikiPathways NNP cord-258172-p54j4zzo 68 80 ( ( -LRB- cord-258172-p54j4zzo 68 81 WP WP NNP cord-258172-p54j4zzo 68 82 ) ) -RRB- cord-258172-p54j4zzo 68 83 ontologies ontology NNS cord-258172-p54j4zzo 68 84 . . . cord-258172-p54j4zzo 69 1 Immunohistochemical immunohistochemical JJ cord-258172-p54j4zzo 69 2 localization localization NN cord-258172-p54j4zzo 69 3 of of IN cord-258172-p54j4zzo 69 4 human human JJ cord-258172-p54j4zzo 69 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 69 6 was be VBD cord-258172-p54j4zzo 69 7 evaluated evaluate VBN cord-258172-p54j4zzo 69 8 from from IN cord-258172-p54j4zzo 69 9 immunostained immunostaine VBN cord-258172-p54j4zzo 69 10 specimens specimen NNS cord-258172-p54j4zzo 69 11 provided provide VBN cord-258172-p54j4zzo 69 12 by by IN cord-258172-p54j4zzo 69 13 Protein Protein NNP cord-258172-p54j4zzo 69 14 Expression Expression NNP cord-258172-p54j4zzo 69 15 Atlas Atlas NNP cord-258172-p54j4zzo 69 16 ( ( -LRB- cord-258172-p54j4zzo 69 17 https://www.proteinatlas.org/ https://www.proteinatlas.org/ ADD cord-258172-p54j4zzo 69 18 ) ) -RRB- cord-258172-p54j4zzo 69 19 [ [ -LRB- cord-258172-p54j4zzo 69 20 42 42 CD cord-258172-p54j4zzo 69 21 ] ] -RRB- cord-258172-p54j4zzo 69 22 . . . cord-258172-p54j4zzo 70 1 The the DT cord-258172-p54j4zzo 70 2 dataset dataset NN cord-258172-p54j4zzo 70 3 included include VBD cord-258172-p54j4zzo 70 4 three three CD cord-258172-p54j4zzo 70 5 specimens specimen NNS cord-258172-p54j4zzo 70 6 of of IN cord-258172-p54j4zzo 70 7 duodenum duodenum NN cord-258172-p54j4zzo 70 8 , , , cord-258172-p54j4zzo 70 9 three three CD cord-258172-p54j4zzo 70 10 specimens specimen NNS cord-258172-p54j4zzo 70 11 of of IN cord-258172-p54j4zzo 70 12 kidney kidney NN cord-258172-p54j4zzo 70 13 , , , cord-258172-p54j4zzo 70 14 three three CD cord-258172-p54j4zzo 70 15 specimens specimen NNS cord-258172-p54j4zzo 70 16 of of IN cord-258172-p54j4zzo 70 17 testis testis NN cord-258172-p54j4zzo 70 18 , , , cord-258172-p54j4zzo 70 19 three three CD cord-258172-p54j4zzo 70 20 specimens specimen NNS cord-258172-p54j4zzo 70 21 of of IN cord-258172-p54j4zzo 70 22 lung lung NN cord-258172-p54j4zzo 70 23 , , , cord-258172-p54j4zzo 70 24 and and CC cord-258172-p54j4zzo 70 25 two two CD cord-258172-p54j4zzo 70 26 specimens specimen NNS cord-258172-p54j4zzo 70 27 of of IN cord-258172-p54j4zzo 70 28 nasopharynx nasopharynx NN cord-258172-p54j4zzo 70 29 . . . cord-258172-p54j4zzo 71 1 The the DT cord-258172-p54j4zzo 71 2 images image NNS cord-258172-p54j4zzo 71 3 of of IN cord-258172-p54j4zzo 71 4 the the DT cord-258172-p54j4zzo 71 5 Fig Fig NNP cord-258172-p54j4zzo 71 6 2 2 CD cord-258172-p54j4zzo 71 7 represent represent VBP cord-258172-p54j4zzo 71 8 duodenum duodenum RB cord-258172-p54j4zzo 71 9 from from IN cord-258172-p54j4zzo 71 10 77-years 77-years CD cord-258172-p54j4zzo 71 11 - - HYPH cord-258172-p54j4zzo 71 12 old old JJ cord-258172-p54j4zzo 71 13 female female NN cord-258172-p54j4zzo 71 14 , , , cord-258172-p54j4zzo 71 15 kidney kidney NN cord-258172-p54j4zzo 71 16 from from IN cord-258172-p54j4zzo 71 17 36-years 36-years CD cord-258172-p54j4zzo 71 18 - - HYPH cord-258172-p54j4zzo 71 19 old old JJ cord-258172-p54j4zzo 71 20 male male NN cord-258172-p54j4zzo 71 21 , , , cord-258172-p54j4zzo 71 22 testis testis NN cord-258172-p54j4zzo 71 23 from from IN cord-258172-p54j4zzo 71 24 38-years 38-years CD cord-258172-p54j4zzo 71 25 - - HYPH cord-258172-p54j4zzo 71 26 old old JJ cord-258172-p54j4zzo 71 27 male male NN cord-258172-p54j4zzo 71 28 , , , cord-258172-p54j4zzo 71 29 lung lung NN cord-258172-p54j4zzo 71 30 from from IN cord-258172-p54j4zzo 71 31 61-years 61-years CD cord-258172-p54j4zzo 71 32 - - HYPH cord-258172-p54j4zzo 71 33 old old JJ cord-258172-p54j4zzo 71 34 female female NN cord-258172-p54j4zzo 71 35 , , , cord-258172-p54j4zzo 71 36 and and CC cord-258172-p54j4zzo 71 37 nasopharyngeal nasopharyngeal JJ cord-258172-p54j4zzo 71 38 mucosa mucosa JJ cord-258172-p54j4zzo 71 39 from from IN cord-258172-p54j4zzo 71 40 78-years 78-years CD cord-258172-p54j4zzo 71 41 - - HYPH cord-258172-p54j4zzo 71 42 old old JJ cord-258172-p54j4zzo 71 43 female female NN cord-258172-p54j4zzo 71 44 . . . cord-258172-p54j4zzo 72 1 According accord VBG cord-258172-p54j4zzo 72 2 to to IN cord-258172-p54j4zzo 72 3 Protein Protein NNP cord-258172-p54j4zzo 72 4 Expression Expression NNP cord-258172-p54j4zzo 72 5 Atlas Atlas NNP cord-258172-p54j4zzo 72 6 the the DT cord-258172-p54j4zzo 72 7 immunostainings immunostaining NNS cord-258172-p54j4zzo 72 8 were be VBD cord-258172-p54j4zzo 72 9 performed perform VBN cord-258172-p54j4zzo 72 10 with with IN cord-258172-p54j4zzo 72 11 the the DT cord-258172-p54j4zzo 72 12 rabbit rabbit NN cord-258172-p54j4zzo 72 13 anti anti JJ cord-258172-p54j4zzo 72 14 - - JJ cord-258172-p54j4zzo 72 15 human human JJ cord-258172-p54j4zzo 72 16 polyclonal polyclonal JJ cord-258172-p54j4zzo 72 17 antibody antibody NN cord-258172-p54j4zzo 72 18 ( ( -LRB- cord-258172-p54j4zzo 72 19 HPA000288 HPA000288 NNP cord-258172-p54j4zzo 72 20 ; ; : cord-258172-p54j4zzo 72 21 Sigma Sigma NNP cord-258172-p54j4zzo 72 22 Aldrich Aldrich NNP cord-258172-p54j4zzo 72 23 , , , cord-258172-p54j4zzo 72 24 St. St. NNP cord-258172-p54j4zzo 72 25 Louis Louis NNP cord-258172-p54j4zzo 72 26 , , , cord-258172-p54j4zzo 72 27 MO MO NNP cord-258172-p54j4zzo 72 28 ) ) -RRB- cord-258172-p54j4zzo 72 29 raised raise VBD cord-258172-p54j4zzo 72 30 against against IN cord-258172-p54j4zzo 72 31 111 111 CD cord-258172-p54j4zzo 72 32 N n CD cord-258172-p54j4zzo 72 33 - - HYPH cord-258172-p54j4zzo 72 34 terminal terminal NN cord-258172-p54j4zzo 72 35 amino amino NN cord-258172-p54j4zzo 72 36 acids acid NNS cord-258172-p54j4zzo 72 37 of of IN cord-258172-p54j4zzo 72 38 ACE2 ACE2 NNP cord-258172-p54j4zzo 72 39 and and CC cord-258172-p54j4zzo 72 40 diluted dilute VBN cord-258172-p54j4zzo 72 41 1:250 1:250 CD cord-258172-p54j4zzo 72 42 for for IN cord-258172-p54j4zzo 72 43 the the DT cord-258172-p54j4zzo 72 44 staining staining NN cord-258172-p54j4zzo 72 45 . . . cord-258172-p54j4zzo 73 1 Analysis analysis NN cord-258172-p54j4zzo 73 2 of of IN cord-258172-p54j4zzo 73 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 73 4 promoter promoter NN cord-258172-p54j4zzo 73 5 regions region NNS cord-258172-p54j4zzo 73 6 was be VBD cord-258172-p54j4zzo 73 7 performed perform VBN cord-258172-p54j4zzo 73 8 using use VBG cord-258172-p54j4zzo 73 9 the the DT cord-258172-p54j4zzo 73 10 TFBSfootprinter TFBSfootprinter NNP cord-258172-p54j4zzo 73 11 tool tool NN cord-258172-p54j4zzo 73 12 ( ( -LRB- cord-258172-p54j4zzo 73 13 https:// https:// NNP cord-258172-p54j4zzo 73 14 github.com/thirtysix/TFBS_footprinting github.com/thirtysix/TFBS_footprinting NNP cord-258172-p54j4zzo 73 15 ) ) -RRB- cord-258172-p54j4zzo 73 16 which which WDT cord-258172-p54j4zzo 73 17 uses use VBZ cord-258172-p54j4zzo 73 18 transcription transcription NN cord-258172-p54j4zzo 73 19 - - HYPH cord-258172-p54j4zzo 73 20 relevant relevant JJ cord-258172-p54j4zzo 73 21 data datum NNS cord-258172-p54j4zzo 73 22 from from IN cord-258172-p54j4zzo 73 23 several several JJ cord-258172-p54j4zzo 73 24 major major JJ cord-258172-p54j4zzo 73 25 databases database NNS cord-258172-p54j4zzo 73 26 to to TO cord-258172-p54j4zzo 73 27 enhance enhance VB cord-258172-p54j4zzo 73 28 prediction prediction NN cord-258172-p54j4zzo 73 29 of of IN cord-258172-p54j4zzo 73 30 putative putative JJ cord-258172-p54j4zzo 73 31 TFBSs tfbs NNS cord-258172-p54j4zzo 73 32 , , , cord-258172-p54j4zzo 73 33 including include VBG cord-258172-p54j4zzo 73 34 : : : cord-258172-p54j4zzo 73 35 all all DT cord-258172-p54j4zzo 73 36 cell cell NN cord-258172-p54j4zzo 73 37 types type NNS cord-258172-p54j4zzo 73 38 aggregated aggregate VBN cord-258172-p54j4zzo 73 39 and and CC cord-258172-p54j4zzo 73 40 merged merge VBD cord-258172-p54j4zzo 73 41 human human JJ cord-258172-p54j4zzo 73 42 ATAC ATAC NNP cord-258172-p54j4zzo 73 43 - - HYPH cord-258172-p54j4zzo 73 44 Seq Seq NNP cord-258172-p54j4zzo 73 45 data datum NNS cord-258172-p54j4zzo 73 46 from from IN cord-258172-p54j4zzo 73 47 ENCODE encode VB cord-258172-p54j4zzo 73 48 [ [ -LRB- cord-258172-p54j4zzo 73 49 43 43 CD cord-258172-p54j4zzo 73 50 ] ] -RRB- cord-258172-p54j4zzo 73 51 , , , cord-258172-p54j4zzo 73 52 transcription transcription NN cord-258172-p54j4zzo 73 53 start start NN cord-258172-p54j4zzo 73 54 sites site NNS cord-258172-p54j4zzo 73 55 and and CC cord-258172-p54j4zzo 73 56 expression expression NN cord-258172-p54j4zzo 73 57 data datum NNS cord-258172-p54j4zzo 73 58 from from IN cord-258172-p54j4zzo 73 59 FANTOM5 FANTOM5 NNP cord-258172-p54j4zzo 73 60 [ [ -LRB- cord-258172-p54j4zzo 73 61 44 44 CD cord-258172-p54j4zzo 73 62 ] ] -RRB- cord-258172-p54j4zzo 73 63 , , , cord-258172-p54j4zzo 73 64 expression expression NN cord-258172-p54j4zzo 73 65 quantitative quantitative JJ cord-258172-p54j4zzo 73 66 trail trail NN cord-258172-p54j4zzo 73 67 loci locus NNS cord-258172-p54j4zzo 73 68 from from IN cord-258172-p54j4zzo 73 69 GTEx GTEx NNS cord-258172-p54j4zzo 73 70 [ [ -LRB- cord-258172-p54j4zzo 73 71 39 39 CD cord-258172-p54j4zzo 73 72 ] ] -RRB- cord-258172-p54j4zzo 73 73 , , , cord-258172-p54j4zzo 73 74 TFBS TFBS NNP cord-258172-p54j4zzo 73 75 metacluster metacluster NN cord-258172-p54j4zzo 73 76 data datum NNS cord-258172-p54j4zzo 73 77 from from IN cord-258172-p54j4zzo 73 78 GTRD GTRD NNP cord-258172-p54j4zzo 73 79 [ [ -LRB- cord-258172-p54j4zzo 73 80 45 45 CD cord-258172-p54j4zzo 73 81 ] ] -RRB- cord-258172-p54j4zzo 73 82 , , , cord-258172-p54j4zzo 73 83 TFBS TFBS NNP cord-258172-p54j4zzo 73 84 binding bind VBG cord-258172-p54j4zzo 73 85 profile profile NN cord-258172-p54j4zzo 73 86 data datum NNS cord-258172-p54j4zzo 73 87 from from IN cord-258172-p54j4zzo 73 88 JASPAR JASPAR NNP cord-258172-p54j4zzo 73 89 [ [ -LRB- cord-258172-p54j4zzo 73 90 46 46 CD cord-258172-p54j4zzo 73 91 ] ] -RRB- cord-258172-p54j4zzo 73 92 , , , cord-258172-p54j4zzo 73 93 and and CC cord-258172-p54j4zzo 73 94 sequence sequence NN cord-258172-p54j4zzo 73 95 and and CC cord-258172-p54j4zzo 73 96 conservation conservation NN cord-258172-p54j4zzo 73 97 data datum NNS cord-258172-p54j4zzo 73 98 from from IN cord-258172-p54j4zzo 73 99 Ensembl Ensembl NNP cord-258172-p54j4zzo 73 100 [ [ -LRB- cord-258172-p54j4zzo 73 101 47 47 CD cord-258172-p54j4zzo 73 102 ] ] -RRB- cord-258172-p54j4zzo 73 103 . . . cord-258172-p54j4zzo 74 1 Detailed detailed JJ cord-258172-p54j4zzo 74 2 description description NN cord-258172-p54j4zzo 74 3 of of IN cord-258172-p54j4zzo 74 4 this this DT cord-258172-p54j4zzo 74 5 novel novel JJ cord-258172-p54j4zzo 74 6 tool tool NN cord-258172-p54j4zzo 74 7 is be VBZ cord-258172-p54j4zzo 74 8 under under IN cord-258172-p54j4zzo 74 9 preparation preparation NN cord-258172-p54j4zzo 74 10 [ [ -LRB- cord-258172-p54j4zzo 74 11 48 48 CD cord-258172-p54j4zzo 74 12 ] ] -RRB- cord-258172-p54j4zzo 74 13 . . . cord-258172-p54j4zzo 75 1 Previous previous JJ cord-258172-p54j4zzo 75 2 studies study NNS cord-258172-p54j4zzo 75 3 identified identify VBD cord-258172-p54j4zzo 75 4 two two CD cord-258172-p54j4zzo 75 5 distinct distinct JJ cord-258172-p54j4zzo 75 6 tissue tissue NN cord-258172-p54j4zzo 75 7 - - HYPH cord-258172-p54j4zzo 75 8 specific specific JJ cord-258172-p54j4zzo 75 9 transcription transcription NN cord-258172-p54j4zzo 75 10 start start NN cord-258172-p54j4zzo 75 11 sites site NNS cord-258172-p54j4zzo 75 12 ( ( -LRB- cord-258172-p54j4zzo 75 13 TSS TSS NNP cord-258172-p54j4zzo 75 14 ) ) -RRB- cord-258172-p54j4zzo 75 15 for for IN cord-258172-p54j4zzo 75 16 intestine intestine NN cord-258172-p54j4zzo 75 17 and and CC cord-258172-p54j4zzo 75 18 lung lung NN cord-258172-p54j4zzo 75 19 expression expression NN cord-258172-p54j4zzo 75 20 [ [ -LRB- cord-258172-p54j4zzo 75 21 49 49 CD cord-258172-p54j4zzo 75 22 ] ] -RRB- cord-258172-p54j4zzo 75 23 , , , cord-258172-p54j4zzo 75 24 which which WDT cord-258172-p54j4zzo 75 25 correspond correspond VBP cord-258172-p54j4zzo 75 26 to to IN cord-258172-p54j4zzo 75 27 primary primary JJ cord-258172-p54j4zzo 75 28 protein protein NN cord-258172-p54j4zzo 75 29 - - HYPH cord-258172-p54j4zzo 75 30 coding code VBG cord-258172-p54j4zzo 75 31 Ensembl Ensembl NNP cord-258172-p54j4zzo 75 32 transcripts transcript NNS cord-258172-p54j4zzo 75 33 ENST00000252519 ENST00000252519 NNP cord-258172-p54j4zzo 75 34 and and CC cord-258172-p54j4zzo 75 35 ENST00000427411 ENST00000427411 NNP cord-258172-p54j4zzo 75 36 , , , cord-258172-p54j4zzo 75 37 respectively respectively RB cord-258172-p54j4zzo 75 38 . . . cord-258172-p54j4zzo 76 1 These these DT cord-258172-p54j4zzo 76 2 two two CD cord-258172-p54j4zzo 76 3 transcripts transcript NNS cord-258172-p54j4zzo 76 4 were be VBD cord-258172-p54j4zzo 76 5 targeted target VBN cord-258172-p54j4zzo 76 6 for for IN cord-258172-p54j4zzo 76 7 transcription transcription NN cord-258172-p54j4zzo 76 8 factor factor NN cord-258172-p54j4zzo 76 9 binding bind VBG cord-258172-p54j4zzo 76 10 site site NN cord-258172-p54j4zzo 76 11 ( ( -LRB- cord-258172-p54j4zzo 76 12 TFBS TFBS NNP cord-258172-p54j4zzo 76 13 ) ) -RRB- cord-258172-p54j4zzo 76 14 analysis analysis NN cord-258172-p54j4zzo 76 15 ; ; : cord-258172-p54j4zzo 76 16 first first RB cord-258172-p54j4zzo 76 17 with with IN cord-258172-p54j4zzo 76 18 a a DT cord-258172-p54j4zzo 76 19 scan scan NN cord-258172-p54j4zzo 76 20 for for IN cord-258172-p54j4zzo 76 21 all all DT cord-258172-p54j4zzo 76 22 575 575 CD cord-258172-p54j4zzo 76 23 Jaspar Jaspar NNP cord-258172-p54j4zzo 76 24 TFs TFs NNPS cord-258172-p54j4zzo 76 25 and and CC cord-258172-p54j4zzo 76 26 input input NN cord-258172-p54j4zzo 76 27 parameters parameter NNS cord-258172-p54j4zzo 76 28 of of IN cord-258172-p54j4zzo 76 29 1,000 1,000 CD cord-258172-p54j4zzo 76 30 base base NN cord-258172-p54j4zzo 76 31 pairs pair NNS cord-258172-p54j4zzo 76 32 ( ( -LRB- cord-258172-p54j4zzo 76 33 bp bp NNP cord-258172-p54j4zzo 76 34 ) ) -RRB- cord-258172-p54j4zzo 76 35 upstream upstream NNP cord-258172-p54j4zzo 76 36 and and CC cord-258172-p54j4zzo 76 37 200 200 CD cord-258172-p54j4zzo 76 38 bp bp NNP cord-258172-p54j4zzo 76 39 downstream downstream NNP cord-258172-p54j4zzo 76 40 ( ( -LRB- cord-258172-p54j4zzo 76 41 relative relative JJ cord-258172-p54j4zzo 76 42 to to IN cord-258172-p54j4zzo 76 43 the the DT cord-258172-p54j4zzo 76 44 TSS TSS NNP cord-258172-p54j4zzo 76 45 ) ) -RRB- cord-258172-p54j4zzo 76 46 ; ; : cord-258172-p54j4zzo 76 47 secondly secondly RB cord-258172-p54j4zzo 76 48 with with IN cord-258172-p54j4zzo 76 49 a a DT cord-258172-p54j4zzo 76 50 limited limited JJ cord-258172-p54j4zzo 76 51 set set NN cord-258172-p54j4zzo 76 52 of of IN cord-258172-p54j4zzo 76 53 15 15 CD cord-258172-p54j4zzo 76 54 interferon interferon NN cord-258172-p54j4zzo 76 55 - - HYPH cord-258172-p54j4zzo 76 56 stimulated stimulate VBN cord-258172-p54j4zzo 76 57 TF TF NNP cord-258172-p54j4zzo 76 58 genes gene NNS cord-258172-p54j4zzo 76 59 and and CC cord-258172-p54j4zzo 76 60 a a DT cord-258172-p54j4zzo 76 61 broader broad JJR cord-258172-p54j4zzo 76 62 area area NN cord-258172-p54j4zzo 76 63 of of IN cord-258172-p54j4zzo 76 64 1,500 1,500 CD cord-258172-p54j4zzo 76 65 bp bp NNP cord-258172-p54j4zzo 76 66 upstream upstream NNP cord-258172-p54j4zzo 76 67 and and CC cord-258172-p54j4zzo 76 68 500 500 CD cord-258172-p54j4zzo 76 69 bp bp NNP cord-258172-p54j4zzo 76 70 downstream downstream NNP cord-258172-p54j4zzo 76 71 . . . cord-258172-p54j4zzo 77 1 Likewise likewise RB cord-258172-p54j4zzo 77 2 , , , cord-258172-p54j4zzo 77 3 an an DT cord-258172-p54j4zzo 77 4 analysis analysis NN cord-258172-p54j4zzo 77 5 of of IN cord-258172-p54j4zzo 77 6 the the DT cord-258172-p54j4zzo 77 7 promoter promoter NN cord-258172-p54j4zzo 77 8 region region NN cord-258172-p54j4zzo 77 9 of of IN cord-258172-p54j4zzo 77 10 a a DT cord-258172-p54j4zzo 77 11 putative putative JJ cord-258172-p54j4zzo 77 12 new new JJ cord-258172-p54j4zzo 77 13 short short JJ cord-258172-p54j4zzo 77 14 form form NN cord-258172-p54j4zzo 77 15 of of IN cord-258172-p54j4zzo 77 16 ACE2 ACE2 NNP cord-258172-p54j4zzo 77 17 was be VBD cord-258172-p54j4zzo 77 18 performed perform VBN cord-258172-p54j4zzo 77 19 . . . cord-258172-p54j4zzo 78 1 Single single JJ cord-258172-p54j4zzo 78 2 - - HYPH cord-258172-p54j4zzo 78 3 cell cell NN cord-258172-p54j4zzo 78 4 expression expression NN cord-258172-p54j4zzo 78 5 datasets dataset NNS cord-258172-p54j4zzo 78 6 were be VBD cord-258172-p54j4zzo 78 7 identified identify VBN cord-258172-p54j4zzo 78 8 for for IN cord-258172-p54j4zzo 78 9 relevant relevant JJ cord-258172-p54j4zzo 78 10 tissues tissue NNS cord-258172-p54j4zzo 78 11 / / SYM cord-258172-p54j4zzo 78 12 cells cell NNS cord-258172-p54j4zzo 78 13 of of IN cord-258172-p54j4zzo 78 14 lung lung NN cord-258172-p54j4zzo 78 15 ( ( -LRB- cord-258172-p54j4zzo 78 16 human human NN cord-258172-p54j4zzo 78 17 ) ) -RRB- cord-258172-p54j4zzo 78 18 [ [ -LRB- cord-258172-p54j4zzo 78 19 50 50 CD cord-258172-p54j4zzo 78 20 ] ] -RRB- cord-258172-p54j4zzo 78 21 , , , cord-258172-p54j4zzo 78 22 trachea trachea NN cord-258172-p54j4zzo 78 23 ( ( -LRB- cord-258172-p54j4zzo 78 24 mouse mouse NN cord-258172-p54j4zzo 78 25 ) ) -RRB- cord-258172-p54j4zzo 78 26 [ [ -LRB- cord-258172-p54j4zzo 78 27 51 51 CD cord-258172-p54j4zzo 78 28 ] ] -RRB- cord-258172-p54j4zzo 78 29 , , , cord-258172-p54j4zzo 78 30 and and CC cord-258172-p54j4zzo 78 31 small small JJ cord-258172-p54j4zzo 78 32 intestine intestine NN cord-258172-p54j4zzo 78 33 ( ( -LRB- cord-258172-p54j4zzo 78 34 mouse mouse NN cord-258172-p54j4zzo 78 35 ) ) -RRB- cord-258172-p54j4zzo 78 36 [ [ -LRB- cord-258172-p54j4zzo 78 37 52 52 CD cord-258172-p54j4zzo 78 38 ] ] -RRB- cord-258172-p54j4zzo 78 39 . . . cord-258172-p54j4zzo 79 1 Using use VBG cord-258172-p54j4zzo 79 2 a a DT cord-258172-p54j4zzo 79 3 modified modify VBN cord-258172-p54j4zzo 79 4 workflow workflow NN cord-258172-p54j4zzo 79 5 described describe VBN cord-258172-p54j4zzo 79 6 previously previously RB cord-258172-p54j4zzo 79 7 in in IN cord-258172-p54j4zzo 79 8 [ [ -LRB- cord-258172-p54j4zzo 79 9 53 53 CD cord-258172-p54j4zzo 79 10 ] ] -RRB- cord-258172-p54j4zzo 79 11 , , , cord-258172-p54j4zzo 79 12 for for IN cord-258172-p54j4zzo 79 13 each each DT cord-258172-p54j4zzo 79 14 dataset dataset NN cord-258172-p54j4zzo 79 15 the the DT cord-258172-p54j4zzo 79 16 samples sample NNS cord-258172-p54j4zzo 79 17 were be VBD cord-258172-p54j4zzo 79 18 filtered filter VBN cord-258172-p54j4zzo 79 19 by by IN cord-258172-p54j4zzo 79 20 Gaussian gaussian JJ cord-258172-p54j4zzo 79 21 fit fit NN cord-258172-p54j4zzo 79 22 of of IN cord-258172-p54j4zzo 79 23 read read JJ cord-258172-p54j4zzo 79 24 count count NN cord-258172-p54j4zzo 79 25 , , , cord-258172-p54j4zzo 79 26 expressed express VBD cord-258172-p54j4zzo 79 27 gene gene NN cord-258172-p54j4zzo 79 28 count count NN cord-258172-p54j4zzo 79 29 , , , cord-258172-p54j4zzo 79 30 and and CC cord-258172-p54j4zzo 79 31 number number NN cord-258172-p54j4zzo 79 32 of of IN cord-258172-p54j4zzo 79 33 cells cell NNS cord-258172-p54j4zzo 79 34 in in IN cord-258172-p54j4zzo 79 35 which which WDT cord-258172-p54j4zzo 79 36 a a DT cord-258172-p54j4zzo 79 37 gene gene NN cord-258172-p54j4zzo 79 38 is be VBZ cord-258172-p54j4zzo 79 39 expressed express VBN cord-258172-p54j4zzo 79 40 . . . cord-258172-p54j4zzo 80 1 Counts count NNS cord-258172-p54j4zzo 80 2 were be VBD cord-258172-p54j4zzo 80 3 normalized normalize VBN cord-258172-p54j4zzo 80 4 by by IN cord-258172-p54j4zzo 80 5 cell cell NN cord-258172-p54j4zzo 80 6 , , , cord-258172-p54j4zzo 80 7 log log NN cord-258172-p54j4zzo 80 8 transformed transform VBN cord-258172-p54j4zzo 80 9 , , , cord-258172-p54j4zzo 80 10 principle principle JJ cord-258172-p54j4zzo 80 11 component component NN cord-258172-p54j4zzo 80 12 analysis analysis NN cord-258172-p54j4zzo 80 13 performed perform VBN cord-258172-p54j4zzo 80 14 with with IN cord-258172-p54j4zzo 80 15 15 15 CD cord-258172-p54j4zzo 80 16 components component NNS cord-258172-p54j4zzo 80 17 , , , cord-258172-p54j4zzo 80 18 and and CC cord-258172-p54j4zzo 80 19 k k NN cord-258172-p54j4zzo 80 20 - - HYPH cord-258172-p54j4zzo 80 21 nearest near JJS cord-258172-p54j4zzo 80 22 neighbors neighbor NNS cord-258172-p54j4zzo 80 23 computed compute VBN cord-258172-p54j4zzo 80 24 using use VBG cord-258172-p54j4zzo 80 25 SCANPY SCANPY NNP cord-258172-p54j4zzo 80 26 [ [ -LRB- cord-258172-p54j4zzo 80 27 54 54 CD cord-258172-p54j4zzo 80 28 ] ] -RRB- cord-258172-p54j4zzo 80 29 , , , cord-258172-p54j4zzo 80 30 and and CC cord-258172-p54j4zzo 80 31 then then RB cord-258172-p54j4zzo 80 32 the the DT cord-258172-p54j4zzo 80 33 full full JJ cord-258172-p54j4zzo 80 34 dataset dataset NN cord-258172-p54j4zzo 80 35 normalized normalize VBN cord-258172-p54j4zzo 80 36 with with IN cord-258172-p54j4zzo 80 37 R r NN cord-258172-p54j4zzo 80 38 package package NN cord-258172-p54j4zzo 80 39 ' ' `` cord-258172-p54j4zzo 80 40 scran scran NN cord-258172-p54j4zzo 80 41 ' ' '' cord-258172-p54j4zzo 80 42 [ [ -LRB- cord-258172-p54j4zzo 80 43 55 55 CD cord-258172-p54j4zzo 80 44 ] ] -RRB- cord-258172-p54j4zzo 80 45 . . . cord-258172-p54j4zzo 81 1 Batch batch JJ cord-258172-p54j4zzo 81 2 correction correction NN cord-258172-p54j4zzo 81 3 by by IN cord-258172-p54j4zzo 81 4 individual individual JJ cord-258172-p54j4zzo 81 5 and and CC cord-258172-p54j4zzo 81 6 sample sample NN cord-258172-p54j4zzo 81 7 region region NN cord-258172-p54j4zzo 81 8 was be VBD cord-258172-p54j4zzo 81 9 performed perform VBN cord-258172-p54j4zzo 81 10 with with IN cord-258172-p54j4zzo 81 11 SCANPY SCANPY NNP cord-258172-p54j4zzo 81 12 using use VBG cord-258172-p54j4zzo 81 13 the the DT cord-258172-p54j4zzo 81 14 ComBat ComBat NNP cord-258172-p54j4zzo 81 15 function function NN cord-258172-p54j4zzo 81 16 . . . cord-258172-p54j4zzo 82 1 The the DT cord-258172-p54j4zzo 82 2 top top JJ cord-258172-p54j4zzo 82 3 1,000 1,000 CD cord-258172-p54j4zzo 82 4 genes gene NNS cord-258172-p54j4zzo 82 5 with with IN cord-258172-p54j4zzo 82 6 highly highly RB cord-258172-p54j4zzo 82 7 differential differential JJ cord-258172-p54j4zzo 82 8 expression expression NN cord-258172-p54j4zzo 82 9 were be VBD cord-258172-p54j4zzo 82 10 identified identify VBN cord-258172-p54j4zzo 82 11 for for IN cord-258172-p54j4zzo 82 12 cluster cluster NN cord-258172-p54j4zzo 82 13 analysis analysis NN cord-258172-p54j4zzo 82 14 which which WDT cord-258172-p54j4zzo 82 15 was be VBD cord-258172-p54j4zzo 82 16 performed perform VBN cord-258172-p54j4zzo 82 17 with with IN cord-258172-p54j4zzo 82 18 Uniform Uniform NNP cord-258172-p54j4zzo 82 19 Manifold Manifold NNP cord-258172-p54j4zzo 82 20 Approximation Approximation NNP cord-258172-p54j4zzo 82 21 and and CC cord-258172-p54j4zzo 82 22 Projection Projection NNP cord-258172-p54j4zzo 82 23 ( ( -LRB- cord-258172-p54j4zzo 82 24 UMAP UMAP NNP cord-258172-p54j4zzo 82 25 ) ) -RRB- cord-258172-p54j4zzo 82 26 and and CC cord-258172-p54j4zzo 82 27 force force NN cord-258172-p54j4zzo 82 28 directed direct VBN cord-258172-p54j4zzo 82 29 graph graph NN cord-258172-p54j4zzo 82 30 models model NNS cord-258172-p54j4zzo 82 31 . . . cord-258172-p54j4zzo 83 1 The the DT cord-258172-p54j4zzo 83 2 top top JJ cord-258172-p54j4zzo 83 3 100 100 CD cord-258172-p54j4zzo 83 4 marker marker NN cord-258172-p54j4zzo 83 5 genes gene NNS cord-258172-p54j4zzo 83 6 were be VBD cord-258172-p54j4zzo 83 7 identified identify VBN cord-258172-p54j4zzo 83 8 as as IN cord-258172-p54j4zzo 83 9 those those DT cord-258172-p54j4zzo 83 10 with with IN cord-258172-p54j4zzo 83 11 higher high JJR cord-258172-p54j4zzo 83 12 expression expression NN cord-258172-p54j4zzo 83 13 unique unique JJ cord-258172-p54j4zzo 83 14 to to IN cord-258172-p54j4zzo 83 15 each each DT cord-258172-p54j4zzo 83 16 cluster cluster NN cord-258172-p54j4zzo 83 17 by by IN cord-258172-p54j4zzo 83 18 Welch Welch NNP cord-258172-p54j4zzo 83 19 t t NN cord-258172-p54j4zzo 83 20 - - HYPH cord-258172-p54j4zzo 83 21 test test NN cord-258172-p54j4zzo 83 22 in in IN cord-258172-p54j4zzo 83 23 SCANPY SCANPY NNP cord-258172-p54j4zzo 83 24 . . . cord-258172-p54j4zzo 84 1 Expression expression NN cord-258172-p54j4zzo 84 2 of of IN cord-258172-p54j4zzo 84 3 the the DT cord-258172-p54j4zzo 84 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 84 5 gene gene NN cord-258172-p54j4zzo 84 6 was be VBD cord-258172-p54j4zzo 84 7 mapped map VBN cord-258172-p54j4zzo 84 8 onto onto IN cord-258172-p54j4zzo 84 9 cluster cluster NN cord-258172-p54j4zzo 84 10 figures figure NNS cord-258172-p54j4zzo 84 11 to to TO cord-258172-p54j4zzo 84 12 determine determine VB cord-258172-p54j4zzo 84 13 overlap overlap VB cord-258172-p54j4zzo 84 14 with with IN cord-258172-p54j4zzo 84 15 previously previously RB cord-258172-p54j4zzo 84 16 identified identify VBN cord-258172-p54j4zzo 84 17 cell cell NN cord-258172-p54j4zzo 84 18 types type NNS cord-258172-p54j4zzo 84 19 or or CC cord-258172-p54j4zzo 84 20 cell cell NN cord-258172-p54j4zzo 84 21 type type NN cord-258172-p54j4zzo 84 22 marker marker NN cord-258172-p54j4zzo 84 23 genes gene NNS cord-258172-p54j4zzo 84 24 identified identify VBN cord-258172-p54j4zzo 84 25 in in IN cord-258172-p54j4zzo 84 26 the the DT cord-258172-p54j4zzo 84 27 literature literature NN cord-258172-p54j4zzo 84 28 . . . cord-258172-p54j4zzo 85 1 Cell cell NN cord-258172-p54j4zzo 85 2 type type NN cord-258172-p54j4zzo 85 3 was be VBD cord-258172-p54j4zzo 85 4 mapped map VBN cord-258172-p54j4zzo 85 5 by by IN cord-258172-p54j4zzo 85 6 expression expression NN cord-258172-p54j4zzo 85 7 of of IN cord-258172-p54j4zzo 85 8 known know VBN cord-258172-p54j4zzo 85 9 marker marker NN cord-258172-p54j4zzo 85 10 genes gene NNS cord-258172-p54j4zzo 85 11 of of IN cord-258172-p54j4zzo 85 12 cell cell NN cord-258172-p54j4zzo 85 13 types type NNS cord-258172-p54j4zzo 85 14 expressed express VBN cord-258172-p54j4zzo 85 15 in in IN cord-258172-p54j4zzo 85 16 the the DT cord-258172-p54j4zzo 85 17 lung lung NN cord-258172-p54j4zzo 85 18 and and CC cord-258172-p54j4zzo 85 19 small small JJ cord-258172-p54j4zzo 85 20 intestine intestine NN cord-258172-p54j4zzo 85 21 , , , cord-258172-p54j4zzo 85 22 as as IN cord-258172-p54j4zzo 85 23 defined define VBN cord-258172-p54j4zzo 85 24 by by IN cord-258172-p54j4zzo 85 25 de de NNP cord-258172-p54j4zzo 85 26 novo novo NNP cord-258172-p54j4zzo 85 27 prediction prediction NN cord-258172-p54j4zzo 85 28 in in IN cord-258172-p54j4zzo 85 29 the the DT cord-258172-p54j4zzo 85 30 original original JJ cord-258172-p54j4zzo 85 31 articles article NNS cord-258172-p54j4zzo 85 32 . . . cord-258172-p54j4zzo 86 1 Comparisons comparison NNS cord-258172-p54j4zzo 86 2 of of IN cord-258172-p54j4zzo 86 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 86 4 expression expression NN cord-258172-p54j4zzo 86 5 values value NNS cord-258172-p54j4zzo 86 6 in in IN cord-258172-p54j4zzo 86 7 different different JJ cord-258172-p54j4zzo 86 8 tissues tissue NNS cord-258172-p54j4zzo 86 9 and and CC cord-258172-p54j4zzo 86 10 between between IN cord-258172-p54j4zzo 86 11 groups group NNS cord-258172-p54j4zzo 86 12 delineated delineate VBN cord-258172-p54j4zzo 86 13 by by IN cord-258172-p54j4zzo 86 14 age age NN cord-258172-p54j4zzo 86 15 or or CC cord-258172-p54j4zzo 86 16 sex sex NN cord-258172-p54j4zzo 86 17 , , , cord-258172-p54j4zzo 86 18 were be VBD cord-258172-p54j4zzo 86 19 carried carry VBN cord-258172-p54j4zzo 86 20 out out RP cord-258172-p54j4zzo 86 21 by by IN cord-258172-p54j4zzo 86 22 one one CD cord-258172-p54j4zzo 86 23 - - HYPH cord-258172-p54j4zzo 86 24 way way NN cord-258172-p54j4zzo 86 25 ANOVA anova NN cord-258172-p54j4zzo 86 26 using use VBG cord-258172-p54j4zzo 86 27 the the DT cord-258172-p54j4zzo 86 28 stats stat NNS cord-258172-p54j4zzo 86 29 package package NN cord-258172-p54j4zzo 86 30 in in IN cord-258172-p54j4zzo 86 31 the the DT cord-258172-p54j4zzo 86 32 SciPy SciPy NNP cord-258172-p54j4zzo 86 33 [ [ -LRB- cord-258172-p54j4zzo 86 34 40 40 CD cord-258172-p54j4zzo 86 35 ] ] -RRB- cord-258172-p54j4zzo 86 36 Python Python NNP cord-258172-p54j4zzo 86 37 library library NN cord-258172-p54j4zzo 86 38 . . . cord-258172-p54j4zzo 87 1 Only only RB cord-258172-p54j4zzo 87 2 groups group NNS cord-258172-p54j4zzo 87 3 with with IN cord-258172-p54j4zzo 87 4 20 20 CD cord-258172-p54j4zzo 87 5 or or CC cord-258172-p54j4zzo 87 6 more more JJR cord-258172-p54j4zzo 87 7 observations observation NNS cord-258172-p54j4zzo 87 8 and and CC cord-258172-p54j4zzo 87 9 a a DT cord-258172-p54j4zzo 87 10 2-sided 2-sided JJ cord-258172-p54j4zzo 87 11 chi chi NNP cord-258172-p54j4zzo 87 12 squared squared JJ cord-258172-p54j4zzo 87 13 probability probability NN cord-258172-p54j4zzo 87 14 of of IN cord-258172-p54j4zzo 87 15 normality normality NN cord-258172-p54j4zzo 87 16 of of IN cord-258172-p54j4zzo 87 17 < < XX cord-258172-p54j4zzo 87 18 = = SYM cord-258172-p54j4zzo 87 19 0.1 0.1 CD cord-258172-p54j4zzo 87 20 ( ( -LRB- cord-258172-p54j4zzo 87 21 due due IN cord-258172-p54j4zzo 87 22 to to IN cord-258172-p54j4zzo 87 23 the the DT cord-258172-p54j4zzo 87 24 robustness robustness NN cord-258172-p54j4zzo 87 25 of of IN cord-258172-p54j4zzo 87 26 ANOVA ANOVA NNP cord-258172-p54j4zzo 87 27 to to IN cord-258172-p54j4zzo 87 28 non non JJ cord-258172-p54j4zzo 87 29 - - JJ cord-258172-p54j4zzo 87 30 normal normal JJ cord-258172-p54j4zzo 87 31 distributions distribution NNS cord-258172-p54j4zzo 87 32 ) ) -RRB- cord-258172-p54j4zzo 87 33 were be VBD cord-258172-p54j4zzo 87 34 used use VBN cord-258172-p54j4zzo 87 35 for for IN cord-258172-p54j4zzo 87 36 comparison comparison NN cord-258172-p54j4zzo 87 37 . . . cord-258172-p54j4zzo 88 1 Correlation correlation NN cord-258172-p54j4zzo 88 2 of of IN cord-258172-p54j4zzo 88 3 gene gene NN cord-258172-p54j4zzo 88 4 expression expression NN cord-258172-p54j4zzo 88 5 values value NNS cord-258172-p54j4zzo 88 6 was be VBD cord-258172-p54j4zzo 88 7 calculated calculate VBN cord-258172-p54j4zzo 88 8 by by IN cord-258172-p54j4zzo 88 9 two two CD cord-258172-p54j4zzo 88 10 - - HYPH cord-258172-p54j4zzo 88 11 sided sided JJ cord-258172-p54j4zzo 88 12 Spearman Spearman NNP cord-258172-p54j4zzo 88 13 rankorder rankorder NN cord-258172-p54j4zzo 88 14 analysis analysis NN cord-258172-p54j4zzo 88 15 , , , cord-258172-p54j4zzo 88 16 where where WRB cord-258172-p54j4zzo 88 17 a a DT cord-258172-p54j4zzo 88 18 Bonferroni Bonferroni NNP cord-258172-p54j4zzo 88 19 - - HYPH cord-258172-p54j4zzo 88 20 corrected correct VBN cord-258172-p54j4zzo 88 21 p p NN cord-258172-p54j4zzo 88 22 - - HYPH cord-258172-p54j4zzo 88 23 value value NN cord-258172-p54j4zzo 88 24 threshold threshold NN cord-258172-p54j4zzo 88 25 was be VBD cord-258172-p54j4zzo 88 26 computed compute VBN cord-258172-p54j4zzo 88 27 using use VBG cord-258172-p54j4zzo 88 28 α α NN cord-258172-p54j4zzo 88 29 = = SYM cord-258172-p54j4zzo 88 30 0.05/ 0.05/ CD cord-258172-p54j4zzo 88 31 number number NN cord-258172-p54j4zzo 88 32 of of IN cord-258172-p54j4zzo 88 33 comparisons comparison NNS cord-258172-p54j4zzo 88 34 . . . cord-258172-p54j4zzo 89 1 Gene gene NN cord-258172-p54j4zzo 89 2 ontology ontology NN cord-258172-p54j4zzo 89 3 enrichment enrichment NN cord-258172-p54j4zzo 89 4 analyses analysis NNS cord-258172-p54j4zzo 89 5 performed perform VBN cord-258172-p54j4zzo 89 6 using use VBG cord-258172-p54j4zzo 89 7 the the DT cord-258172-p54j4zzo 89 8 GProfiler GProfiler NNP cord-258172-p54j4zzo 89 9 tool tool NN cord-258172-p54j4zzo 89 10 utilize utilize VBP cord-258172-p54j4zzo 89 11 a a DT cord-258172-p54j4zzo 89 12 custom custom NN cord-258172-p54j4zzo 89 13 algorithm algorithm NN cord-258172-p54j4zzo 89 14 for for IN cord-258172-p54j4zzo 89 15 multiple multiple JJ cord-258172-p54j4zzo 89 16 testing testing NN cord-258172-p54j4zzo 89 17 of of IN cord-258172-p54j4zzo 89 18 dependent dependent JJ cord-258172-p54j4zzo 89 19 results result NNS cord-258172-p54j4zzo 89 20 , , , cord-258172-p54j4zzo 89 21 which which WDT cord-258172-p54j4zzo 89 22 corresponds correspond VBZ cord-258172-p54j4zzo 89 23 to to IN cord-258172-p54j4zzo 89 24 an an DT cord-258172-p54j4zzo 89 25 experiment experiment NN cord-258172-p54j4zzo 89 26 - - HYPH cord-258172-p54j4zzo 89 27 wide wide JJ cord-258172-p54j4zzo 89 28 threshold threshold NN cord-258172-p54j4zzo 89 29 of of IN cord-258172-p54j4zzo 89 30 α α NN cord-258172-p54j4zzo 89 31 = = SYM cord-258172-p54j4zzo 89 32 0.05 0.05 CD cord-258172-p54j4zzo 89 33 . . . cord-258172-p54j4zzo 90 1 TFBSfootprinter TFBSfootprinter NNP cord-258172-p54j4zzo 90 2 analysis analysis NNP cord-258172-p54j4zzo 90 3 of of IN cord-258172-p54j4zzo 90 4 the the DT cord-258172-p54j4zzo 90 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 90 6 promoter promoter NN cord-258172-p54j4zzo 90 7 limits limit VBZ cord-258172-p54j4zzo 90 8 results result NNS cord-258172-p54j4zzo 90 9 for for IN cord-258172-p54j4zzo 90 10 individual individual JJ cord-258172-p54j4zzo 90 11 TFBSs tfbs NNS cord-258172-p54j4zzo 90 12 whose whose WP$ cord-258172-p54j4zzo 90 13 score score NN cord-258172-p54j4zzo 90 14 satisfies satisfy VBZ cord-258172-p54j4zzo 90 15 a a DT cord-258172-p54j4zzo 90 16 genome genome NN cord-258172-p54j4zzo 90 17 - - HYPH cord-258172-p54j4zzo 90 18 wide wide JJ cord-258172-p54j4zzo 90 19 threshold threshold NN cord-258172-p54j4zzo 90 20 of of IN cord-258172-p54j4zzo 90 21 α α NN cord-258172-p54j4zzo 90 22 = = SYM cord-258172-p54j4zzo 90 23 0.01 0.01 CD cord-258172-p54j4zzo 90 24 . . . cord-258172-p54j4zzo 91 1 The the DT cord-258172-p54j4zzo 91 2 first first JJ cord-258172-p54j4zzo 91 3 aim aim NN cord-258172-p54j4zzo 91 4 of of IN cord-258172-p54j4zzo 91 5 our -PRON- PRP$ cord-258172-p54j4zzo 91 6 study study NN cord-258172-p54j4zzo 91 7 was be VBD cord-258172-p54j4zzo 91 8 to to TO cord-258172-p54j4zzo 91 9 investigate investigate VB cord-258172-p54j4zzo 91 10 different different JJ cord-258172-p54j4zzo 91 11 human human JJ cord-258172-p54j4zzo 91 12 tissues tissue NNS cord-258172-p54j4zzo 91 13 using use VBG cord-258172-p54j4zzo 91 14 publicly publicly RB cord-258172-p54j4zzo 91 15 available available JJ cord-258172-p54j4zzo 91 16 datasets dataset NNS cord-258172-p54j4zzo 91 17 for for IN cord-258172-p54j4zzo 91 18 the the DT cord-258172-p54j4zzo 91 19 distribution distribution NN cord-258172-p54j4zzo 91 20 of of IN cord-258172-p54j4zzo 91 21 ACE2 ACE2 NNP cord-258172-p54j4zzo 91 22 mRNA mRNA NNP cord-258172-p54j4zzo 91 23 and and CC cord-258172-p54j4zzo 91 24 protein protein NN cord-258172-p54j4zzo 91 25 . . . cord-258172-p54j4zzo 92 1 In in IN cord-258172-p54j4zzo 92 2 the the DT cord-258172-p54j4zzo 92 3 FANTOM5 fantom5 NN cord-258172-p54j4zzo 92 4 dataset dataset NN cord-258172-p54j4zzo 92 5 , , , cord-258172-p54j4zzo 92 6 the the DT cord-258172-p54j4zzo 92 7 highest high JJS cord-258172-p54j4zzo 92 8 values value NNS cord-258172-p54j4zzo 92 9 for for IN cord-258172-p54j4zzo 92 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 92 11 mRNA mRNA NNP cord-258172-p54j4zzo 92 12 , , , cord-258172-p54j4zzo 92 13 ranked rank VBN cord-258172-p54j4zzo 92 14 according accord VBG cord-258172-p54j4zzo 92 15 to to IN cord-258172-p54j4zzo 92 16 signal signal JJ cord-258172-p54j4zzo 92 17 intensity intensity NN cord-258172-p54j4zzo 92 18 , , , cord-258172-p54j4zzo 92 19 were be VBD cord-258172-p54j4zzo 92 20 seen see VBN cord-258172-p54j4zzo 92 21 for for IN cord-258172-p54j4zzo 92 22 the the DT cord-258172-p54j4zzo 92 23 small small JJ cord-258172-p54j4zzo 92 24 intestine intestine NN cord-258172-p54j4zzo 92 25 , , , cord-258172-p54j4zzo 92 26 dura dura NNP cord-258172-p54j4zzo 92 27 mater mater NN cord-258172-p54j4zzo 92 28 , , , cord-258172-p54j4zzo 92 29 colon colon NN cord-258172-p54j4zzo 92 30 , , , cord-258172-p54j4zzo 92 31 testis testis NN cord-258172-p54j4zzo 92 32 , , , cord-258172-p54j4zzo 92 33 thalamus thalamus NN cord-258172-p54j4zzo 92 34 , , , cord-258172-p54j4zzo 92 35 and and CC cord-258172-p54j4zzo 92 36 rectum rectum NN cord-258172-p54j4zzo 92 37 ( ( -LRB- cord-258172-p54j4zzo 92 38 Fig Fig NNP cord-258172-p54j4zzo 92 39 1 1 CD cord-258172-p54j4zzo 92 40 ) ) -RRB- cord-258172-p54j4zzo 92 41 . . . cord-258172-p54j4zzo 93 1 Fig fig NN cord-258172-p54j4zzo 93 2 2 2 CD cord-258172-p54j4zzo 93 3 shows show VBZ cord-258172-p54j4zzo 93 4 the the DT cord-258172-p54j4zzo 93 5 expression expression NN cord-258172-p54j4zzo 93 6 of of IN cord-258172-p54j4zzo 93 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 93 8 protein protein NN cord-258172-p54j4zzo 93 9 in in IN cord-258172-p54j4zzo 93 10 selected select VBN cord-258172-p54j4zzo 93 11 human human JJ cord-258172-p54j4zzo 93 12 tissues tissue NNS cord-258172-p54j4zzo 93 13 . . . cord-258172-p54j4zzo 94 1 Representative representative JJ cord-258172-p54j4zzo 94 2 example example NN cord-258172-p54j4zzo 94 3 images image NNS cord-258172-p54j4zzo 94 4 of of IN cord-258172-p54j4zzo 94 5 the the DT cord-258172-p54j4zzo 94 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 94 7 immunostaining immunostaining NN cord-258172-p54j4zzo 94 8 were be VBD cord-258172-p54j4zzo 94 9 prepared prepare VBN cord-258172-p54j4zzo 94 10 from from IN cord-258172-p54j4zzo 94 11 tissue tissue NN cord-258172-p54j4zzo 94 12 specimens specimen NNS cord-258172-p54j4zzo 94 13 of of IN cord-258172-p54j4zzo 94 14 the the DT cord-258172-p54j4zzo 94 15 Human Human NNP cord-258172-p54j4zzo 94 16 Protein Protein NNP cord-258172-p54j4zzo 94 17 Atlas Atlas NNP cord-258172-p54j4zzo 94 18 database database NN cord-258172-p54j4zzo 94 19 ( ( -LRB- cord-258172-p54j4zzo 94 20 https://www.proteinatlas.org/ https://www.proteinatlas.org/ ADD cord-258172-p54j4zzo 94 21 ) ) -RRB- cord-258172-p54j4zzo 94 22 . . . cord-258172-p54j4zzo 95 1 The the DT cord-258172-p54j4zzo 95 2 results result NNS cord-258172-p54j4zzo 95 3 indicate indicate VBP cord-258172-p54j4zzo 95 4 a a DT cord-258172-p54j4zzo 95 5 strong strong JJ cord-258172-p54j4zzo 95 6 signal signal NN cord-258172-p54j4zzo 95 7 for for IN cord-258172-p54j4zzo 95 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 95 9 protein protein NN cord-258172-p54j4zzo 95 10 in in IN cord-258172-p54j4zzo 95 11 the the DT cord-258172-p54j4zzo 95 12 brush brush NN cord-258172-p54j4zzo 95 13 border border NN cord-258172-p54j4zzo 95 14 of of IN cord-258172-p54j4zzo 95 15 small small JJ cord-258172-p54j4zzo 95 16 intestinal intestinal JJ cord-258172-p54j4zzo 95 17 enterocytes enterocyte NNS cord-258172-p54j4zzo 95 18 . . . cord-258172-p54j4zzo 96 1 In in IN cord-258172-p54j4zzo 96 2 the the DT cord-258172-p54j4zzo 96 3 kidney kidney NN cord-258172-p54j4zzo 96 4 , , , cord-258172-p54j4zzo 96 5 strong strong JJ cord-258172-p54j4zzo 96 6 immunostaining immunostaining NN cord-258172-p54j4zzo 96 7 reactions reaction NNS cord-258172-p54j4zzo 96 8 were be VBD cord-258172-p54j4zzo 96 9 present present JJ cord-258172-p54j4zzo 96 10 in in IN cord-258172-p54j4zzo 96 11 the the DT cord-258172-p54j4zzo 96 12 epithelial epithelial JJ cord-258172-p54j4zzo 96 13 cells cell NNS cord-258172-p54j4zzo 96 14 of of IN cord-258172-p54j4zzo 96 15 proximal proximal JJ cord-258172-p54j4zzo 96 16 convoluted convoluted JJ cord-258172-p54j4zzo 96 17 tubules tubule NNS cord-258172-p54j4zzo 96 18 and and CC cord-258172-p54j4zzo 96 19 Bowman´s Bowman´s NNP cord-258172-p54j4zzo 96 20 capsule capsule NN cord-258172-p54j4zzo 96 21 . . . cord-258172-p54j4zzo 97 1 The the DT cord-258172-p54j4zzo 97 2 seminiferous seminiferous JJ cord-258172-p54j4zzo 97 3 tubules tubule NNS cord-258172-p54j4zzo 97 4 and and CC cord-258172-p54j4zzo 97 5 interstitial interstitial JJ cord-258172-p54j4zzo 97 6 cells cell NNS cord-258172-p54j4zzo 97 7 of of IN cord-258172-p54j4zzo 97 8 testis testis NN cord-258172-p54j4zzo 97 9 also also RB cord-258172-p54j4zzo 97 10 demonstrated demonstrate VBD cord-258172-p54j4zzo 97 11 strong strong JJ cord-258172-p54j4zzo 97 12 immunostaining immunostaining NN cord-258172-p54j4zzo 97 13 . . . cord-258172-p54j4zzo 98 1 No no DT cord-258172-p54j4zzo 98 2 immunoreactions immunoreaction NNS cord-258172-p54j4zzo 98 3 for for IN cord-258172-p54j4zzo 98 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 98 5 were be VBD cord-258172-p54j4zzo 98 6 observed observe VBN cord-258172-p54j4zzo 98 7 in in IN cord-258172-p54j4zzo 98 8 the the DT cord-258172-p54j4zzo 98 9 lung lung NN cord-258172-p54j4zzo 98 10 specimens specimen NNS cord-258172-p54j4zzo 98 11 . . . cord-258172-p54j4zzo 99 1 Very very RB cord-258172-p54j4zzo 99 2 weak weak JJ cord-258172-p54j4zzo 99 3 signal signal NN cord-258172-p54j4zzo 99 4 , , , cord-258172-p54j4zzo 99 5 associated associate VBN cord-258172-p54j4zzo 99 6 with with IN cord-258172-p54j4zzo 99 7 apical apical JJ cord-258172-p54j4zzo 99 8 membranes membrane NNS cord-258172-p54j4zzo 99 9 , , , cord-258172-p54j4zzo 99 10 was be VBD cord-258172-p54j4zzo 99 11 detected detect VBN cord-258172-p54j4zzo 99 12 in in IN cord-258172-p54j4zzo 99 13 sporadic sporadic JJ cord-258172-p54j4zzo 99 14 ciliary ciliary NN cord-258172-p54j4zzo 99 15 cells cell NNS cord-258172-p54j4zzo 99 16 of of IN cord-258172-p54j4zzo 99 17 a a DT cord-258172-p54j4zzo 99 18 nasopharyngeal nasopharyngeal JJ cord-258172-p54j4zzo 99 19 mucosa mucosa JJ cord-258172-p54j4zzo 99 20 sample sample NN cord-258172-p54j4zzo 99 21 . . . cord-258172-p54j4zzo 100 1 Although although IN cord-258172-p54j4zzo 100 2 the the DT cord-258172-p54j4zzo 100 3 evaluation evaluation NN cord-258172-p54j4zzo 100 4 of of IN cord-258172-p54j4zzo 100 5 immunostaining immunostaine VBG cord-258172-p54j4zzo 100 6 reaction reaction NN cord-258172-p54j4zzo 100 7 is be VBZ cord-258172-p54j4zzo 100 8 generally generally RB cord-258172-p54j4zzo 100 9 considered consider VBN cord-258172-p54j4zzo 100 10 semiquantitative semiquantitative NN cord-258172-p54j4zzo 100 11 at at IN cord-258172-p54j4zzo 100 12 most most JJS cord-258172-p54j4zzo 100 13 , , , cord-258172-p54j4zzo 100 14 the the DT cord-258172-p54j4zzo 100 15 results result NNS cord-258172-p54j4zzo 100 16 seem seem VBP cord-258172-p54j4zzo 100 17 to to TO cord-258172-p54j4zzo 100 18 correlate correlate VB cord-258172-p54j4zzo 100 19 fairly fairly RB cord-258172-p54j4zzo 100 20 well well RB cord-258172-p54j4zzo 100 21 with with IN cord-258172-p54j4zzo 100 22 the the DT cord-258172-p54j4zzo 100 23 corresponding correspond VBG cord-258172-p54j4zzo 100 24 mRNA mrna NN cord-258172-p54j4zzo 100 25 expression expression NN cord-258172-p54j4zzo 100 26 levels level NNS cord-258172-p54j4zzo 100 27 . . . cord-258172-p54j4zzo 101 1 The the DT cord-258172-p54j4zzo 101 2 respiratory respiratory JJ cord-258172-p54j4zzo 101 3 tract tract NN cord-258172-p54j4zzo 101 4 is be VBZ cord-258172-p54j4zzo 101 5 the the DT cord-258172-p54j4zzo 101 6 main main JJ cord-258172-p54j4zzo 101 7 target target NN cord-258172-p54j4zzo 101 8 region region NN cord-258172-p54j4zzo 101 9 that that WDT cord-258172-p54j4zzo 101 10 is be VBZ cord-258172-p54j4zzo 101 11 affected affect VBN cord-258172-p54j4zzo 101 12 by by IN cord-258172-p54j4zzo 101 13 COVID-19 covid-19 JJ cord-258172-p54j4zzo 101 14 infection infection NN cord-258172-p54j4zzo 101 15 . . . cord-258172-p54j4zzo 102 1 Bulk Bulk NNP cord-258172-p54j4zzo 102 2 RNA RNA NNP cord-258172-p54j4zzo 102 3 - - HYPH cord-258172-p54j4zzo 102 4 Seq Seq NNP cord-258172-p54j4zzo 102 5 data datum NNS cord-258172-p54j4zzo 102 6 from from IN cord-258172-p54j4zzo 102 7 lung lung NN cord-258172-p54j4zzo 102 8 specimens specimen NNS cord-258172-p54j4zzo 102 9 showed show VBD cord-258172-p54j4zzo 102 10 low low JJ cord-258172-p54j4zzo 102 11 expression expression NN cord-258172-p54j4zzo 102 12 levels level NNS cord-258172-p54j4zzo 102 13 for for IN cord-258172-p54j4zzo 102 14 ACE2 ACE2 NNP cord-258172-p54j4zzo 102 15 ( ( -LRB- cord-258172-p54j4zzo 102 16 Fig Fig NNP cord-258172-p54j4zzo 102 17 1 1 CD cord-258172-p54j4zzo 102 18 ) ) -RRB- cord-258172-p54j4zzo 102 19 . . . cord-258172-p54j4zzo 103 1 Therefore therefore RB cord-258172-p54j4zzo 103 2 , , , cord-258172-p54j4zzo 103 3 we -PRON- PRP cord-258172-p54j4zzo 103 4 performed perform VBD cord-258172-p54j4zzo 103 5 an an DT cord-258172-p54j4zzo 103 6 analysis analysis NN cord-258172-p54j4zzo 103 7 of of IN cord-258172-p54j4zzo 103 8 single single JJ cord-258172-p54j4zzo 103 9 cell cell NN cord-258172-p54j4zzo 103 10 RNA rna NN cord-258172-p54j4zzo 103 11 - - HYPH cord-258172-p54j4zzo 103 12 Seq Seq NNP cord-258172-p54j4zzo 103 13 using use VBG cord-258172-p54j4zzo 103 14 both both DT cord-258172-p54j4zzo 103 15 human human JJ cord-258172-p54j4zzo 103 16 lung lung NN cord-258172-p54j4zzo 103 17 and and CC cord-258172-p54j4zzo 103 18 mouse mouse NN cord-258172-p54j4zzo 103 19 trachea trachea NN cord-258172-p54j4zzo 103 20 datasets dataset NNS cord-258172-p54j4zzo 103 21 , , , cord-258172-p54j4zzo 103 22 representing represent VBG cord-258172-p54j4zzo 103 23 the the DT cord-258172-p54j4zzo 103 24 breadth breadth NN cord-258172-p54j4zzo 103 25 of of IN cord-258172-p54j4zzo 103 26 the the DT cord-258172-p54j4zzo 103 27 lower low JJR cord-258172-p54j4zzo 103 28 respiratory respiratory JJ cord-258172-p54j4zzo 103 29 tract tract NN cord-258172-p54j4zzo 103 30 . . . cord-258172-p54j4zzo 104 1 Figs fig NNS cord-258172-p54j4zzo 104 2 3 3 CD cord-258172-p54j4zzo 104 3 and and CC cord-258172-p54j4zzo 104 4 4 4 CD cord-258172-p54j4zzo 104 5 show show VBP cord-258172-p54j4zzo 104 6 the the DT cord-258172-p54j4zzo 104 7 expression expression NN cord-258172-p54j4zzo 104 8 of of IN cord-258172-p54j4zzo 104 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 104 10 mRNA mrna NN cord-258172-p54j4zzo 104 11 in in IN cord-258172-p54j4zzo 104 12 identified identify VBN cord-258172-p54j4zzo 104 13 cell cell NN cord-258172-p54j4zzo 104 14 types type NNS cord-258172-p54j4zzo 104 15 of of IN cord-258172-p54j4zzo 104 16 lung lung NN cord-258172-p54j4zzo 104 17 and and CC cord-258172-p54j4zzo 104 18 trachea trachea NN cord-258172-p54j4zzo 104 19 , , , cord-258172-p54j4zzo 104 20 respectively respectively RB cord-258172-p54j4zzo 104 21 . . . cord-258172-p54j4zzo 105 1 In in IN cord-258172-p54j4zzo 105 2 lung lung NN cord-258172-p54j4zzo 105 3 , , , cord-258172-p54j4zzo 105 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 105 5 expressing express VBG cord-258172-p54j4zzo 105 6 cells cell NNS cord-258172-p54j4zzo 105 7 are be VBP cord-258172-p54j4zzo 105 8 generally generally RB cord-258172-p54j4zzo 105 9 uncommon uncommon JJ cord-258172-p54j4zzo 105 10 with with IN cord-258172-p54j4zzo 105 11 no no DT cord-258172-p54j4zzo 105 12 cell cell NN cord-258172-p54j4zzo 105 13 type type NN cord-258172-p54j4zzo 105 14 having have VBG cord-258172-p54j4zzo 105 15 a a DT cord-258172-p54j4zzo 105 16 ratio ratio NN cord-258172-p54j4zzo 105 17 of of IN cord-258172-p54j4zzo 105 18 ACE2-expressing ace2-expresse VBG cord-258172-p54j4zzo 105 19 cells cell NNS cord-258172-p54j4zzo 105 20 greater great JJR cord-258172-p54j4zzo 105 21 than than IN cord-258172-p54j4zzo 105 22 2.6 2.6 CD cord-258172-p54j4zzo 105 23 % % NN cord-258172-p54j4zzo 105 24 . . . cord-258172-p54j4zzo 106 1 The the DT cord-258172-p54j4zzo 106 2 cell cell NN cord-258172-p54j4zzo 106 3 types type NNS cord-258172-p54j4zzo 106 4 with with IN cord-258172-p54j4zzo 106 5 the the DT cord-258172-p54j4zzo 106 6 greatest great JJS cord-258172-p54j4zzo 106 7 proportion proportion NN cord-258172-p54j4zzo 106 8 of of IN cord-258172-p54j4zzo 106 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 106 10 expression expression NN cord-258172-p54j4zzo 106 11 are be VBP cord-258172-p54j4zzo 106 12 those those DT cord-258172-p54j4zzo 106 13 of of IN cord-258172-p54j4zzo 106 14 arterial arterial JJ cord-258172-p54j4zzo 106 15 vascular vascular JJ cord-258172-p54j4zzo 106 16 endothelial endothelial JJ cord-258172-p54j4zzo 106 17 cells cell NNS cord-258172-p54j4zzo 106 18 ( ( -LRB- cord-258172-p54j4zzo 106 19 2.55 2.55 CD cord-258172-p54j4zzo 106 20 % % NN cord-258172-p54j4zzo 106 21 ) ) -RRB- cord-258172-p54j4zzo 106 22 , , , cord-258172-p54j4zzo 106 23 goblet goblet NN cord-258172-p54j4zzo 106 24 cells cell NNS cord-258172-p54j4zzo 106 25 ( ( -LRB- cord-258172-p54j4zzo 106 26 2.02 2.02 CD cord-258172-p54j4zzo 106 27 % % NN cord-258172-p54j4zzo 106 28 ) ) -RRB- cord-258172-p54j4zzo 106 29 , , , cord-258172-p54j4zzo 106 30 and and CC cord-258172-p54j4zzo 106 31 venous venous JJ cord-258172-p54j4zzo 106 32 vascular vascular JJ cord-258172-p54j4zzo 106 33 endothelial endothelial JJ cord-258172-p54j4zzo 106 34 cells cell NNS cord-258172-p54j4zzo 106 35 ( ( -LRB- cord-258172-p54j4zzo 106 36 1.33 1.33 CD cord-258172-p54j4zzo 106 37 % % NN cord-258172-p54j4zzo 106 38 ) ) -RRB- cord-258172-p54j4zzo 106 39 . . . cord-258172-p54j4zzo 107 1 In in IN cord-258172-p54j4zzo 107 2 trachea trachea NN cord-258172-p54j4zzo 107 3 , , , cord-258172-p54j4zzo 107 4 the the DT cord-258172-p54j4zzo 107 5 highest high JJS cord-258172-p54j4zzo 107 6 ratio ratio NN cord-258172-p54j4zzo 107 7 of of IN cord-258172-p54j4zzo 107 8 ACE2-expressing ace2-expresse VBG cord-258172-p54j4zzo 107 9 cells cell NNS cord-258172-p54j4zzo 107 10 included include VBD cord-258172-p54j4zzo 107 11 the the DT cord-258172-p54j4zzo 107 12 club club NN cord-258172-p54j4zzo 107 13 cells cell NNS cord-258172-p54j4zzo 107 14 ( ( -LRB- cord-258172-p54j4zzo 107 15 16.62 16.62 CD cord-258172-p54j4zzo 107 16 % % NN cord-258172-p54j4zzo 107 17 ) ) -RRB- cord-258172-p54j4zzo 107 18 , , , cord-258172-p54j4zzo 107 19 goblet goblet NN cord-258172-p54j4zzo 107 20 cells cell NNS cord-258172-p54j4zzo 107 21 ( ( -LRB- cord-258172-p54j4zzo 107 22 13.84 13.84 CD cord-258172-p54j4zzo 107 23 % % NN cord-258172-p54j4zzo 107 24 ) ) -RRB- cord-258172-p54j4zzo 107 25 , , , cord-258172-p54j4zzo 107 26 and and CC cord-258172-p54j4zzo 107 27 ciliary ciliary NN cord-258172-p54j4zzo 107 28 epithelial epithelial JJ cord-258172-p54j4zzo 107 29 cells cell NNS cord-258172-p54j4zzo 107 30 ( ( -LRB- cord-258172-p54j4zzo 107 31 6.63 6.63 CD cord-258172-p54j4zzo 107 32 % % NN cord-258172-p54j4zzo 107 33 ) ) -RRB- cord-258172-p54j4zzo 107 34 . . . cord-258172-p54j4zzo 108 1 Since since IN cord-258172-p54j4zzo 108 2 both both CC cord-258172-p54j4zzo 108 3 the the DT cord-258172-p54j4zzo 108 4 airways airway NNS cord-258172-p54j4zzo 108 5 and and CC cord-258172-p54j4zzo 108 6 intestine intestine NN cord-258172-p54j4zzo 108 7 contain contain VBP cord-258172-p54j4zzo 108 8 goblet goblet NN cord-258172-p54j4zzo 108 9 cells cell NNS cord-258172-p54j4zzo 108 10 , , , cord-258172-p54j4zzo 108 11 SARS SARS NNP cord-258172-p54j4zzo 108 12 - - HYPH cord-258172-p54j4zzo 108 13 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 108 14 affects affect VBZ cord-258172-p54j4zzo 108 15 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 108 16 tract tract NN cord-258172-p54j4zzo 108 17 , , , cord-258172-p54j4zzo 108 18 and and CC cord-258172-p54j4zzo 108 19 bulk bulk JJ cord-258172-p54j4zzo 108 20 RNA RNA NNP cord-258172-p54j4zzo 108 21 - - HYPH cord-258172-p54j4zzo 108 22 Seq Seq NNP cord-258172-p54j4zzo 108 23 data datum NNS cord-258172-p54j4zzo 108 24 shows show VBZ cord-258172-p54j4zzo 108 25 high high JJ cord-258172-p54j4zzo 108 26 expression expression NN cord-258172-p54j4zzo 108 27 in in IN cord-258172-p54j4zzo 108 28 small small JJ cord-258172-p54j4zzo 108 29 intestine intestine NN cord-258172-p54j4zzo 108 30 and and CC cord-258172-p54j4zzo 108 31 colon colon NN cord-258172-p54j4zzo 108 32 , , , cord-258172-p54j4zzo 108 33 we -PRON- PRP cord-258172-p54j4zzo 108 34 decided decide VBD cord-258172-p54j4zzo 108 35 to to TO cord-258172-p54j4zzo 108 36 analyze analyze VB cord-258172-p54j4zzo 108 37 another another DT cord-258172-p54j4zzo 108 38 single single JJ cord-258172-p54j4zzo 108 39 cell cell NN cord-258172-p54j4zzo 108 40 RNA rna NN cord-258172-p54j4zzo 108 41 - - HYPH cord-258172-p54j4zzo 108 42 Seq Seq NNP cord-258172-p54j4zzo 108 43 dataset dataset NN cord-258172-p54j4zzo 108 44 covering cover VBG cord-258172-p54j4zzo 108 45 mouse mouse NN cord-258172-p54j4zzo 108 46 intestinal intestinal JJ cord-258172-p54j4zzo 108 47 epithelial epithelial JJ cord-258172-p54j4zzo 108 48 cells cell NNS cord-258172-p54j4zzo 108 49 . . . cord-258172-p54j4zzo 108 50 _SP cord-258172-p54j4zzo 109 1 Since since IN cord-258172-p54j4zzo 109 2 both both DT cord-258172-p54j4zzo 109 3 age age NN cord-258172-p54j4zzo 109 4 and and CC cord-258172-p54j4zzo 109 5 gender gender NN cord-258172-p54j4zzo 109 6 may may MD cord-258172-p54j4zzo 109 7 contribute contribute VB cord-258172-p54j4zzo 109 8 to to IN cord-258172-p54j4zzo 109 9 onset onset NN cord-258172-p54j4zzo 109 10 and and CC cord-258172-p54j4zzo 109 11 severity severity NN cord-258172-p54j4zzo 109 12 of of IN cord-258172-p54j4zzo 109 13 COVID-19 covid-19 JJ cord-258172-p54j4zzo 109 14 symptoms symptom NNS cord-258172-p54j4zzo 109 15 we -PRON- PRP cord-258172-p54j4zzo 109 16 aimed aim VBD cord-258172-p54j4zzo 109 17 to to TO cord-258172-p54j4zzo 109 18 investigate investigate VB cord-258172-p54j4zzo 109 19 the the DT cord-258172-p54j4zzo 109 20 effect effect NN cord-258172-p54j4zzo 109 21 of of IN cord-258172-p54j4zzo 109 22 these these DT cord-258172-p54j4zzo 109 23 variables variable NNS cord-258172-p54j4zzo 109 24 on on IN cord-258172-p54j4zzo 109 25 the the DT cord-258172-p54j4zzo 109 26 expression expression NN cord-258172-p54j4zzo 109 27 levels level NNS cord-258172-p54j4zzo 109 28 of of IN cord-258172-p54j4zzo 109 29 ACE2 ACE2 NNP cord-258172-p54j4zzo 109 30 mRNA mrna NN cord-258172-p54j4zzo 109 31 . . . cord-258172-p54j4zzo 110 1 Fig Fig NNP cord-258172-p54j4zzo 110 2 6 6 CD cord-258172-p54j4zzo 110 3 _SP cord-258172-p54j4zzo 110 4 indicates indicate VBZ cord-258172-p54j4zzo 110 5 that that IN cord-258172-p54j4zzo 110 6 some some DT cord-258172-p54j4zzo 110 7 tissues tissue NNS cord-258172-p54j4zzo 110 8 showed show VBD cord-258172-p54j4zzo 110 9 a a DT cord-258172-p54j4zzo 110 10 slight slight JJ cord-258172-p54j4zzo 110 11 trend trend NN cord-258172-p54j4zzo 110 12 to to IN cord-258172-p54j4zzo 110 13 lower low JJR cord-258172-p54j4zzo 110 14 expression expression NN cord-258172-p54j4zzo 110 15 in in IN cord-258172-p54j4zzo 110 16 older old JJR cord-258172-p54j4zzo 110 17 age age NN cord-258172-p54j4zzo 110 18 categories category NNS cord-258172-p54j4zzo 110 19 . . . cord-258172-p54j4zzo 111 1 Among among IN cord-258172-p54j4zzo 111 2 all all DT cord-258172-p54j4zzo 111 3 tested test VBN cord-258172-p54j4zzo 111 4 tissues tissue NNS cord-258172-p54j4zzo 111 5 , , , cord-258172-p54j4zzo 111 6 statistically statistically RB cord-258172-p54j4zzo 111 7 significant significant JJ cord-258172-p54j4zzo 111 8 differences difference NNS cord-258172-p54j4zzo 111 9 between between IN cord-258172-p54j4zzo 111 10 the the DT cord-258172-p54j4zzo 111 11 age age NN cord-258172-p54j4zzo 111 12 categories category NNS cord-258172-p54j4zzo 111 13 were be VBD cord-258172-p54j4zzo 111 14 Immunohistochemical immunohistochemical JJ cord-258172-p54j4zzo 111 15 localization localization NN cord-258172-p54j4zzo 111 16 of of IN cord-258172-p54j4zzo 111 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 111 18 protein protein NN cord-258172-p54j4zzo 111 19 in in IN cord-258172-p54j4zzo 111 20 selected select VBN cord-258172-p54j4zzo 111 21 human human JJ cord-258172-p54j4zzo 111 22 tissues tissue NNS cord-258172-p54j4zzo 111 23 . . . cord-258172-p54j4zzo 112 1 In in IN cord-258172-p54j4zzo 112 2 the the DT cord-258172-p54j4zzo 112 3 duodenum duodenum NN cord-258172-p54j4zzo 112 4 ( ( -LRB- cord-258172-p54j4zzo 112 5 A A NNP cord-258172-p54j4zzo 112 6 ) ) -RRB- cord-258172-p54j4zzo 112 7 , , , cord-258172-p54j4zzo 112 8 the the DT cord-258172-p54j4zzo 112 9 protein protein NN cord-258172-p54j4zzo 112 10 is be VBZ cord-258172-p54j4zzo 112 11 most most RBS cord-258172-p54j4zzo 112 12 strongly strongly RB cord-258172-p54j4zzo 112 13 localized localize VBN cord-258172-p54j4zzo 112 14 to to IN cord-258172-p54j4zzo 112 15 the the DT cord-258172-p54j4zzo 112 16 apical apical JJ cord-258172-p54j4zzo 112 17 plasma plasma NN cord-258172-p54j4zzo 112 18 membrane membrane NN cord-258172-p54j4zzo 112 19 of of IN cord-258172-p54j4zzo 112 20 absorptive absorptive JJ cord-258172-p54j4zzo 112 21 enterocytes enterocyte NNS cord-258172-p54j4zzo 112 22 ( ( -LRB- cord-258172-p54j4zzo 112 23 arrows arrow NNS cord-258172-p54j4zzo 112 24 ) ) -RRB- cord-258172-p54j4zzo 112 25 . . . cord-258172-p54j4zzo 113 1 The the DT cord-258172-p54j4zzo 113 2 goblet goblet NN cord-258172-p54j4zzo 113 3 cells cell NNS cord-258172-p54j4zzo 113 4 ( ( -LRB- cord-258172-p54j4zzo 113 5 arrowheads arrowhead NNS cord-258172-p54j4zzo 113 6 ) ) -RRB- cord-258172-p54j4zzo 113 7 show show VBP cord-258172-p54j4zzo 113 8 weaker weak JJR cord-258172-p54j4zzo 113 9 apical apical JJ cord-258172-p54j4zzo 113 10 staining staining NN cord-258172-p54j4zzo 113 11 . . . cord-258172-p54j4zzo 114 1 Intracellular Intracellular NNP cord-258172-p54j4zzo 114 2 staining staining NN cord-258172-p54j4zzo 114 3 is be VBZ cord-258172-p54j4zzo 114 4 confined confine VBN cord-258172-p54j4zzo 114 5 to to IN cord-258172-p54j4zzo 114 6 the the DT cord-258172-p54j4zzo 114 7 absorptive absorptive JJ cord-258172-p54j4zzo 114 8 enterocytes enterocyte NNS cord-258172-p54j4zzo 114 9 . . . cord-258172-p54j4zzo 115 1 In in IN cord-258172-p54j4zzo 115 2 the the DT cord-258172-p54j4zzo 115 3 kidney kidney NN cord-258172-p54j4zzo 115 4 ( ( -LRB- cord-258172-p54j4zzo 115 5 B b NN cord-258172-p54j4zzo 115 6 ) ) -RRB- cord-258172-p54j4zzo 115 7 , , , cord-258172-p54j4zzo 115 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 115 9 shows show VBZ cord-258172-p54j4zzo 115 10 strong strong JJ cord-258172-p54j4zzo 115 11 apical apical JJ cord-258172-p54j4zzo 115 12 staining staining NN cord-258172-p54j4zzo 115 13 in in IN cord-258172-p54j4zzo 115 14 the the DT cord-258172-p54j4zzo 115 15 epithelial epithelial JJ cord-258172-p54j4zzo 115 16 cells cell NNS cord-258172-p54j4zzo 115 17 of of IN cord-258172-p54j4zzo 115 18 the the DT cord-258172-p54j4zzo 115 19 proximal proximal JJ cord-258172-p54j4zzo 115 20 convoluted convoluted JJ cord-258172-p54j4zzo 115 21 tubules tubule NNS cord-258172-p54j4zzo 115 22 ( ( -LRB- cord-258172-p54j4zzo 115 23 arrows arrow NNS cord-258172-p54j4zzo 115 24 ) ) -RRB- cord-258172-p54j4zzo 115 25 and and CC cord-258172-p54j4zzo 115 26 Bowman´s Bowman´s NNP cord-258172-p54j4zzo 115 27 capsule capsule NN cord-258172-p54j4zzo 115 28 epithelium epithelium NN cord-258172-p54j4zzo 115 29 ( ( -LRB- cord-258172-p54j4zzo 115 30 arrowheads arrowhead NNS cord-258172-p54j4zzo 115 31 ) ) -RRB- cord-258172-p54j4zzo 115 32 . . . cord-258172-p54j4zzo 116 1 The the DT cord-258172-p54j4zzo 116 2 distal distal JJ cord-258172-p54j4zzo 116 3 convoluted convoluted JJ cord-258172-p54j4zzo 116 4 tubules tubule NNS cord-258172-p54j4zzo 116 5 are be VBP cord-258172-p54j4zzo 116 6 negative negative JJ cord-258172-p54j4zzo 116 7 ( ( -LRB- cord-258172-p54j4zzo 116 8 asterisk asterisk NN cord-258172-p54j4zzo 116 9 ) ) -RRB- cord-258172-p54j4zzo 116 10 . . . cord-258172-p54j4zzo 117 1 The the DT cord-258172-p54j4zzo 117 2 testis testis NN cord-258172-p54j4zzo 117 3 specimen specimen NN cord-258172-p54j4zzo 117 4 ( ( -LRB- cord-258172-p54j4zzo 117 5 C c NN cord-258172-p54j4zzo 117 6 ) ) -RRB- cord-258172-p54j4zzo 117 7 shows show VBZ cord-258172-p54j4zzo 117 8 strong strong JJ cord-258172-p54j4zzo 117 9 immunostaining immunostaining NN cord-258172-p54j4zzo 117 10 in in IN cord-258172-p54j4zzo 117 11 the the DT cord-258172-p54j4zzo 117 12 seminiferous seminiferous JJ cord-258172-p54j4zzo 117 13 tubules tubule NNS cord-258172-p54j4zzo 117 14 ( ( -LRB- cord-258172-p54j4zzo 117 15 arrows arrow NNS cord-258172-p54j4zzo 117 16 ) ) -RRB- cord-258172-p54j4zzo 117 17 and and CC cord-258172-p54j4zzo 117 18 interstitial interstitial JJ cord-258172-p54j4zzo 117 19 cells cell NNS cord-258172-p54j4zzo 117 20 ( ( -LRB- cord-258172-p54j4zzo 117 21 arrowheads arrowhead NNS cord-258172-p54j4zzo 117 22 ) ) -RRB- cord-258172-p54j4zzo 117 23 . . . cord-258172-p54j4zzo 118 1 The the DT cord-258172-p54j4zzo 118 2 lung lung NN cord-258172-p54j4zzo 118 3 sample sample NN cord-258172-p54j4zzo 118 4 ( ( -LRB- cord-258172-p54j4zzo 118 5 D D NNP cord-258172-p54j4zzo 118 6 ) ) -RRB- cord-258172-p54j4zzo 118 7 is be VBZ cord-258172-p54j4zzo 118 8 negative negative JJ cord-258172-p54j4zzo 118 9 . . . cord-258172-p54j4zzo 119 1 In in IN cord-258172-p54j4zzo 119 2 the the DT cord-258172-p54j4zzo 119 3 nasopharyngeal nasopharyngeal JJ cord-258172-p54j4zzo 119 4 mucosa mucosa JJ cord-258172-p54j4zzo 119 5 ( ( -LRB- cord-258172-p54j4zzo 119 6 E E NNP cord-258172-p54j4zzo 119 7 ) ) -RRB- cord-258172-p54j4zzo 119 8 , , , cord-258172-p54j4zzo 119 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 119 10 signal signal NN cord-258172-p54j4zzo 119 11 is be VBZ cord-258172-p54j4zzo 119 12 very very RB cord-258172-p54j4zzo 119 13 weak weak JJ cord-258172-p54j4zzo 119 14 and and CC cord-258172-p54j4zzo 120 1 only only RB cord-258172-p54j4zzo 120 2 occasional occasional JJ cord-258172-p54j4zzo 120 3 epithelial epithelial JJ cord-258172-p54j4zzo 120 4 cells cell NNS cord-258172-p54j4zzo 120 5 show show VBP cord-258172-p54j4zzo 120 6 weak weak JJ cord-258172-p54j4zzo 120 7 signals signal NNS cord-258172-p54j4zzo 120 8 ( ( -LRB- cord-258172-p54j4zzo 120 9 arrows arrow NNS cord-258172-p54j4zzo 120 10 ) ) -RRB- cord-258172-p54j4zzo 120 11 . . . cord-258172-p54j4zzo 121 1 Immunostained immunostained JJ cord-258172-p54j4zzo 121 2 specimens specimen NNS cord-258172-p54j4zzo 121 3 were be VBD cord-258172-p54j4zzo 121 4 taken take VBN cord-258172-p54j4zzo 121 5 from from IN cord-258172-p54j4zzo 121 6 the the DT cord-258172-p54j4zzo 121 7 Protein Protein NNP cord-258172-p54j4zzo 121 8 Expression Expression NNP cord-258172-p54j4zzo 121 9 Atlas Atlas NNP cord-258172-p54j4zzo 121 10 ( ( -LRB- cord-258172-p54j4zzo 121 11 https://www https://www . cord-258172-p54j4zzo 121 12 . . . cord-258172-p54j4zzo 122 1 proteinatlas.org/ proteinatlas.org/ NNP cord-258172-p54j4zzo 122 2 ) ) -RRB- cord-258172-p54j4zzo 122 3 . . . cord-258172-p54j4zzo 122 4 https://doi.org/10.1371/journal.pone.0240647.g002 https://doi.org/10.1371/journal.pone.0240647.g002 ADD cord-258172-p54j4zzo 122 5 seen see VBN cord-258172-p54j4zzo 122 6 in in IN cord-258172-p54j4zzo 122 7 the the DT cord-258172-p54j4zzo 122 8 tibial tibial JJ cord-258172-p54j4zzo 122 9 nerve nerve NN cord-258172-p54j4zzo 122 10 ( ( -LRB- cord-258172-p54j4zzo 122 11 p p NN cord-258172-p54j4zzo 122 12 = = SYM cord-258172-p54j4zzo 122 13 8.58 8.58 CD cord-258172-p54j4zzo 122 14 x x SYM cord-258172-p54j4zzo 122 15 10 10 CD cord-258172-p54j4zzo 122 16 −6 −6 NNP cord-258172-p54j4zzo 122 17 ) ) -RRB- cord-258172-p54j4zzo 122 18 , , , cord-258172-p54j4zzo 122 19 minor minor JJ cord-258172-p54j4zzo 122 20 salivary salivary NN cord-258172-p54j4zzo 122 21 gland gland NN cord-258172-p54j4zzo 122 22 ( ( -LRB- cord-258172-p54j4zzo 122 23 p p NN cord-258172-p54j4zzo 122 24 = = SYM cord-258172-p54j4zzo 122 25 0.002 0.002 CD cord-258172-p54j4zzo 122 26 ) ) -RRB- cord-258172-p54j4zzo 122 27 , , , cord-258172-p54j4zzo 122 28 aorta aorta NN cord-258172-p54j4zzo 122 29 ( ( -LRB- cord-258172-p54j4zzo 122 30 p p NN cord-258172-p54j4zzo 122 31 = = SYM cord-258172-p54j4zzo 122 32 0.003 0.003 CD cord-258172-p54j4zzo 122 33 ) ) -RRB- cord-258172-p54j4zzo 122 34 , , , cord-258172-p54j4zzo 122 35 whole whole JJ cord-258172-p54j4zzo 122 36 blood blood NN cord-258172-p54j4zzo 122 37 ( ( -LRB- cord-258172-p54j4zzo 122 38 p p NN cord-258172-p54j4zzo 122 39 = = SYM cord-258172-p54j4zzo 122 40 0.005 0.005 CD cord-258172-p54j4zzo 122 41 ) ) -RRB- cord-258172-p54j4zzo 122 42 , , , cord-258172-p54j4zzo 122 43 transverse transverse JJ cord-258172-p54j4zzo 122 44 colon colon NN cord-258172-p54j4zzo 122 45 ( ( -LRB- cord-258172-p54j4zzo 122 46 p p NN cord-258172-p54j4zzo 122 47 = = SYM cord-258172-p54j4zzo 122 48 0.010 0.010 CD cord-258172-p54j4zzo 122 49 ) ) -RRB- cord-258172-p54j4zzo 122 50 , , , cord-258172-p54j4zzo 122 51 hypothalamus hypothalamus NN cord-258172-p54j4zzo 122 52 ( ( -LRB- cord-258172-p54j4zzo 122 53 p p NN cord-258172-p54j4zzo 122 54 = = SYM cord-258172-p54j4zzo 122 55 0.039 0.039 CD cord-258172-p54j4zzo 122 56 ) ) -RRB- cord-258172-p54j4zzo 122 57 , , , cord-258172-p54j4zzo 122 58 and and CC cord-258172-p54j4zzo 122 59 sun sun NN cord-258172-p54j4zzo 122 60 exposed expose VBD cord-258172-p54j4zzo 122 61 skin skin NN cord-258172-p54j4zzo 122 62 ( ( -LRB- cord-258172-p54j4zzo 122 63 p p NN cord-258172-p54j4zzo 122 64 = = SYM cord-258172-p54j4zzo 122 65 0.046 0.046 CD cord-258172-p54j4zzo 122 66 ) ) -RRB- cord-258172-p54j4zzo 122 67 . . . cord-258172-p54j4zzo 123 1 Importantly importantly RB cord-258172-p54j4zzo 123 2 , , , cord-258172-p54j4zzo 123 3 the the DT cord-258172-p54j4zzo 123 4 lung lung NN cord-258172-p54j4zzo 123 5 specimens specimen NNS cord-258172-p54j4zzo 123 6 showed show VBD cord-258172-p54j4zzo 123 7 no no DT cord-258172-p54j4zzo 123 8 significant significant JJ cord-258172-p54j4zzo 123 9 difference difference NN cord-258172-p54j4zzo 123 10 of of IN cord-258172-p54j4zzo 123 11 ACE2 ACE2 NNP cord-258172-p54j4zzo 123 12 mRNA mRNA NNP cord-258172-p54j4zzo 123 13 expression expression NN cord-258172-p54j4zzo 123 14 as as IN cord-258172-p54j4zzo 123 15 normalized normalize VBN cord-258172-p54j4zzo 123 16 , , , cord-258172-p54j4zzo 123 17 batch batch NN cord-258172-p54j4zzo 123 18 - - HYPH cord-258172-p54j4zzo 123 19 corrected correct VBN cord-258172-p54j4zzo 123 20 counts count NNS cord-258172-p54j4zzo 123 21 is be VBZ cord-258172-p54j4zzo 123 22 shown show VBN cord-258172-p54j4zzo 123 23 for for IN cord-258172-p54j4zzo 123 24 comparison comparison NN cord-258172-p54j4zzo 123 25 in in IN cord-258172-p54j4zzo 123 26 upper upper JJ cord-258172-p54j4zzo 123 27 panel panel NN cord-258172-p54j4zzo 123 28 . . . cord-258172-p54j4zzo 124 1 The the DT cord-258172-p54j4zzo 124 2 force force NN cord-258172-p54j4zzo 124 3 directed direct VBD cord-258172-p54j4zzo 124 4 layout layout NN cord-258172-p54j4zzo 124 5 plot plot NN cord-258172-p54j4zzo 124 6 was be VBD cord-258172-p54j4zzo 124 7 computed compute VBN cord-258172-p54j4zzo 124 8 and and CC cord-258172-p54j4zzo 124 9 visualized visualize VBN cord-258172-p54j4zzo 124 10 in in IN cord-258172-p54j4zzo 124 11 ScanPy scanpy CD cord-258172-p54j4zzo 124 12 [ [ -LRB- cord-258172-p54j4zzo 124 13 54 54 CD cord-258172-p54j4zzo 124 14 ] ] -RRB- cord-258172-p54j4zzo 124 15 . . . cord-258172-p54j4zzo 125 1 For for IN cord-258172-p54j4zzo 125 2 each each DT cord-258172-p54j4zzo 125 3 cell cell NN cord-258172-p54j4zzo 125 4 type type NN cord-258172-p54j4zzo 125 5 the the DT cord-258172-p54j4zzo 125 6 ratio ratio NN cord-258172-p54j4zzo 125 7 of of IN cord-258172-p54j4zzo 125 8 cells cell NNS cord-258172-p54j4zzo 125 9 expressing express VBG cord-258172-p54j4zzo 125 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 125 11 is be VBZ cord-258172-p54j4zzo 125 12 presented present VBN cord-258172-p54j4zzo 125 13 in in IN cord-258172-p54j4zzo 125 14 addition addition NN cord-258172-p54j4zzo 125 15 to to IN cord-258172-p54j4zzo 125 16 a a DT cord-258172-p54j4zzo 125 17 stacked stack VBN cord-258172-p54j4zzo 125 18 barplot barplot NN cord-258172-p54j4zzo 125 19 of of IN cord-258172-p54j4zzo 125 20 the the DT cord-258172-p54j4zzo 125 21 relative relative JJ cord-258172-p54j4zzo 125 22 cell cell NN cord-258172-p54j4zzo 125 23 type type NN cord-258172-p54j4zzo 125 24 frequencies frequency NNS cord-258172-p54j4zzo 125 25 in in IN cord-258172-p54j4zzo 125 26 the the DT cord-258172-p54j4zzo 125 27 whole whole JJ cord-258172-p54j4zzo 125 28 dataset dataset NN cord-258172-p54j4zzo 125 29 . . . cord-258172-p54j4zzo 126 1 Alveolar alveolar NN cord-258172-p54j4zzo 126 2 type type NN cord-258172-p54j4zzo 126 3 I -PRON- PRP cord-258172-p54j4zzo 126 4 ( ( -LRB- cord-258172-p54j4zzo 126 5 ATI ATI NNP cord-258172-p54j4zzo 126 6 ) ) -RRB- cord-258172-p54j4zzo 126 7 , , , cord-258172-p54j4zzo 126 8 alveolar alveolar NN cord-258172-p54j4zzo 126 9 type type NN cord-258172-p54j4zzo 126 10 II II NNP cord-258172-p54j4zzo 126 11 ( ( -LRB- cord-258172-p54j4zzo 126 12 ATII ATII NNP cord-258172-p54j4zzo 126 13 ) ) -RRB- cord-258172-p54j4zzo 126 14 , , , cord-258172-p54j4zzo 126 15 pulmonary pulmonary JJ cord-258172-p54j4zzo 126 16 neuroendocrine neuroendocrine JJ cord-258172-p54j4zzo 126 17 cells cell NNS cord-258172-p54j4zzo 126 18 ( ( -LRB- cord-258172-p54j4zzo 126 19 PNEC PNEC NNP cord-258172-p54j4zzo 126 20 ) ) -RRB- cord-258172-p54j4zzo 126 21 , , , cord-258172-p54j4zzo 126 22 smooth smooth JJ cord-258172-p54j4zzo 126 23 muscle muscle NN cord-258172-p54j4zzo 126 24 cells cell NNS cord-258172-p54j4zzo 126 25 ( ( -LRB- cord-258172-p54j4zzo 126 26 SMC SMC NNP cord-258172-p54j4zzo 126 27 ) ) -RRB- cord-258172-p54j4zzo 126 28 , , , cord-258172-p54j4zzo 126 29 vascular vascular JJ cord-258172-p54j4zzo 126 30 endothelia endothelia NNP cord-258172-p54j4zzo 126 31 ( ( -LRB- cord-258172-p54j4zzo 126 32 VE VE NNP cord-258172-p54j4zzo 126 33 ) ) -RRB- cord-258172-p54j4zzo 126 34 . . . cord-258172-p54j4zzo 127 1 https://doi.org/10.1371/journal.pone.0240647.g003 https://doi.org/10.1371/journal.pone.0240647.g003 DT cord-258172-p54j4zzo 127 2 ACE2 ACE2 NNP cord-258172-p54j4zzo 127 3 mRNA mrna NN cord-258172-p54j4zzo 128 1 expression expression NN cord-258172-p54j4zzo 128 2 between between IN cord-258172-p54j4zzo 128 3 different different JJ cord-258172-p54j4zzo 128 4 age age NN cord-258172-p54j4zzo 128 5 categories category NNS cord-258172-p54j4zzo 128 6 ( ( -LRB- cord-258172-p54j4zzo 128 7 p p NN cord-258172-p54j4zzo 128 8 = = SYM cord-258172-p54j4zzo 128 9 0.681 0.681 CD cord-258172-p54j4zzo 128 10 ) ) -RRB- cord-258172-p54j4zzo 128 11 . . . cord-258172-p54j4zzo 129 1 Complete complete JJ cord-258172-p54j4zzo 129 2 data datum NNS cord-258172-p54j4zzo 129 3 on on IN cord-258172-p54j4zzo 130 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 130 2 mRNA mrna NN cord-258172-p54j4zzo 130 3 expression expression NN cord-258172-p54j4zzo 130 4 levels level NNS cord-258172-p54j4zzo 130 5 in in IN cord-258172-p54j4zzo 130 6 different different JJ cord-258172-p54j4zzo 130 7 age age NN cord-258172-p54j4zzo 130 8 categories category NNS cord-258172-p54j4zzo 130 9 are be VBP cord-258172-p54j4zzo 130 10 shown show VBN cord-258172-p54j4zzo 130 11 in in IN cord-258172-p54j4zzo 130 12 S2 S2 NNP cord-258172-p54j4zzo 130 13 Table Table NNP cord-258172-p54j4zzo 130 14 . . . cord-258172-p54j4zzo 131 1 To to TO cord-258172-p54j4zzo 131 2 make make VB cord-258172-p54j4zzo 131 3 a a DT cord-258172-p54j4zzo 131 4 binary binary JJ cord-258172-p54j4zzo 131 5 comparison comparison NN cord-258172-p54j4zzo 131 6 of of IN cord-258172-p54j4zzo 131 7 expression expression NN cord-258172-p54j4zzo 131 8 by by IN cord-258172-p54j4zzo 131 9 age age NN cord-258172-p54j4zzo 131 10 , , , cord-258172-p54j4zzo 131 11 samples sample NNS cord-258172-p54j4zzo 131 12 were be VBD cord-258172-p54j4zzo 131 13 divided divide VBN cord-258172-p54j4zzo 131 14 into into IN cord-258172-p54j4zzo 131 15 groups group NNS cord-258172-p54j4zzo 131 16 of of IN cord-258172-p54j4zzo 131 17 < < XX cord-258172-p54j4zzo 131 18 50 50 CD cord-258172-p54j4zzo 131 19 and and CC cord-258172-p54j4zzo 131 20 � � CD cord-258172-p54j4zzo 131 21 50 50 CD cord-258172-p54j4zzo 131 22 years year NNS cord-258172-p54j4zzo 131 23 of of IN cord-258172-p54j4zzo 131 24 age age NN cord-258172-p54j4zzo 131 25 . . . cord-258172-p54j4zzo 132 1 In in IN cord-258172-p54j4zzo 132 2 comparison comparison NN cord-258172-p54j4zzo 132 3 of of IN cord-258172-p54j4zzo 132 4 these these DT cord-258172-p54j4zzo 132 5 younger young JJR cord-258172-p54j4zzo 132 6 and and CC cord-258172-p54j4zzo 132 7 older old JJR cord-258172-p54j4zzo 132 8 age age NN cord-258172-p54j4zzo 132 9 groups group NNS cord-258172-p54j4zzo 132 10 , , , cord-258172-p54j4zzo 132 11 significant significant JJ cord-258172-p54j4zzo 132 12 differences difference NNS cord-258172-p54j4zzo 132 13 in in IN cord-258172-p54j4zzo 132 14 expression expression NN cord-258172-p54j4zzo 132 15 were be VBD cord-258172-p54j4zzo 132 16 found find VBN cord-258172-p54j4zzo 132 17 in in IN cord-258172-p54j4zzo 132 18 tibial tibial JJ cord-258172-p54j4zzo 132 19 nerve nerve NN cord-258172-p54j4zzo 132 20 ( ( -LRB- cord-258172-p54j4zzo 132 21 p p NN cord-258172-p54j4zzo 132 22 = = SYM cord-258172-p54j4zzo 132 23 2.47 2.47 CD cord-258172-p54j4zzo 132 24 x x SYM cord-258172-p54j4zzo 132 25 10 10 CD cord-258172-p54j4zzo 132 26 −7 −7 NNP cord-258172-p54j4zzo 132 27 ) ) -RRB- cord-258172-p54j4zzo 132 28 , , , cord-258172-p54j4zzo 132 29 whole whole JJ cord-258172-p54j4zzo 132 30 blood blood NN cord-258172-p54j4zzo 132 31 ( ( -LRB- cord-258172-p54j4zzo 132 32 p p NN cord-258172-p54j4zzo 132 33 = = SYM cord-258172-p54j4zzo 132 34 3.21 3.21 CD cord-258172-p54j4zzo 132 35 x x SYM cord-258172-p54j4zzo 132 36 10 10 CD cord-258172-p54j4zzo 132 37 −4 −4 CD cord-258172-p54j4zzo 132 38 ) ) -RRB- cord-258172-p54j4zzo 132 39 , , . cord-258172-p54j4zzo 133 1 minor minor JJ cord-258172-p54j4zzo 133 2 salivary salivary NN cord-258172-p54j4zzo 133 3 gland gland NN cord-258172-p54j4zzo 133 4 ( ( -LRB- cord-258172-p54j4zzo 133 5 p p NN cord-258172-p54j4zzo 133 6 = = SYM cord-258172-p54j4zzo 133 7 4.89 4.89 CD cord-258172-p54j4zzo 133 8 x x SYM cord-258172-p54j4zzo 133 9 10 10 CD cord-258172-p54j4zzo 133 10 −4 −4 CD cord-258172-p54j4zzo 133 11 ) ) -RRB- cord-258172-p54j4zzo 134 1 , , , cord-258172-p54j4zzo 134 2 sun sun NN cord-258172-p54j4zzo 134 3 exposed expose VBD cord-258172-p54j4zzo 134 4 skin skin NN cord-258172-p54j4zzo 134 5 ( ( -LRB- cord-258172-p54j4zzo 134 6 p p NN cord-258172-p54j4zzo 134 7 = = SYM cord-258172-p54j4zzo 134 8 0.003 0.003 CD cord-258172-p54j4zzo 134 9 ) ) -RRB- cord-258172-p54j4zzo 134 10 , , , cord-258172-p54j4zzo 134 11 transverse transverse JJ cord-258172-p54j4zzo 134 12 colon colon NN cord-258172-p54j4zzo 134 13 ( ( -LRB- cord-258172-p54j4zzo 134 14 p p NN cord-258172-p54j4zzo 134 15 = = SYM cord-258172-p54j4zzo 134 16 0.022 0.022 CD cord-258172-p54j4zzo 134 17 ) ) -RRB- cord-258172-p54j4zzo 134 18 , , , cord-258172-p54j4zzo 134 19 testis testis NN cord-258172-p54j4zzo 134 20 ( ( -LRB- cord-258172-p54j4zzo 134 21 p p NN cord-258172-p54j4zzo 134 22 = = SYM cord-258172-p54j4zzo 134 23 0.025 0.025 CD cord-258172-p54j4zzo 134 24 ) ) -RRB- cord-258172-p54j4zzo 134 25 , , , cord-258172-p54j4zzo 134 26 esophageal esophageal JJ cord-258172-p54j4zzo 134 27 muscle muscle NN cord-258172-p54j4zzo 134 28 layer layer NN cord-258172-p54j4zzo 134 29 ( ( -LRB- cord-258172-p54j4zzo 134 30 p p NN cord-258172-p54j4zzo 134 31 = = SYM cord-258172-p54j4zzo 134 32 0.040 0.040 CD cord-258172-p54j4zzo 134 33 ) ) -RRB- cord-258172-p54j4zzo 134 34 , , , cord-258172-p54j4zzo 134 35 and and CC cord-258172-p54j4zzo 134 36 subcutaneous subcutaneous JJ cord-258172-p54j4zzo 134 37 adipose adipose JJ cord-258172-p54j4zzo 134 38 tissue tissue NN cord-258172-p54j4zzo 134 39 ( ( -LRB- cord-258172-p54j4zzo 134 40 p p NN cord-258172-p54j4zzo 134 41 = = SYM cord-258172-p54j4zzo 134 42 0.045 0.045 CD cord-258172-p54j4zzo 134 43 ) ) -RRB- cord-258172-p54j4zzo 134 44 . . . cord-258172-p54j4zzo 135 1 Additionally additionally RB cord-258172-p54j4zzo 135 2 , , , cord-258172-p54j4zzo 135 3 with with IN cord-258172-p54j4zzo 135 4 the the DT cord-258172-p54j4zzo 135 5 same same JJ cord-258172-p54j4zzo 135 6 age age NN cord-258172-p54j4zzo 135 7 groups group NNS cord-258172-p54j4zzo 135 8 , , , cord-258172-p54j4zzo 135 9 comparisons comparison NNS cord-258172-p54j4zzo 135 10 were be VBD cord-258172-p54j4zzo 135 11 made make VBN cord-258172-p54j4zzo 135 12 for for IN cord-258172-p54j4zzo 135 13 both both DT cord-258172-p54j4zzo 135 14 males male NNS cord-258172-p54j4zzo 135 15 and and CC cord-258172-p54j4zzo 135 16 females female NNS cord-258172-p54j4zzo 135 17 ( ( -LRB- cord-258172-p54j4zzo 135 18 S3 S3 NNP cord-258172-p54j4zzo 135 19 Table Table NNP cord-258172-p54j4zzo 135 20 ) ) -RRB- cord-258172-p54j4zzo 135 21 . . . cord-258172-p54j4zzo 136 1 In in IN cord-258172-p54j4zzo 136 2 males male NNS cord-258172-p54j4zzo 136 3 , , , cord-258172-p54j4zzo 136 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 136 5 expression expression NN cord-258172-p54j4zzo 136 6 was be VBD cord-258172-p54j4zzo 136 7 lower low JJR cord-258172-p54j4zzo 136 8 in in IN cord-258172-p54j4zzo 136 9 the the DT cord-258172-p54j4zzo 136 10 � � CD cord-258172-p54j4zzo 136 11 50 50 CD cord-258172-p54j4zzo 136 12 age age NN cord-258172-p54j4zzo 136 13 group group NN cord-258172-p54j4zzo 136 14 for for IN cord-258172-p54j4zzo 136 15 tibial tibial JJ cord-258172-p54j4zzo 136 16 nerve nerve NN cord-258172-p54j4zzo 136 17 , , , cord-258172-p54j4zzo 136 18 sigmoid sigmoid JJ cord-258172-p54j4zzo 136 19 colon colon NN cord-258172-p54j4zzo 136 20 ( ( -LRB- cord-258172-p54j4zzo 136 21 p p NN cord-258172-p54j4zzo 136 22 = = SYM cord-258172-p54j4zzo 136 23 0.017 0.017 CD cord-258172-p54j4zzo 136 24 ) ) -RRB- cord-258172-p54j4zzo 136 25 , , , cord-258172-p54j4zzo 136 26 testis testis NN cord-258172-p54j4zzo 136 27 ( ( -LRB- cord-258172-p54j4zzo 136 28 p p NN cord-258172-p54j4zzo 136 29 = = SYM cord-258172-p54j4zzo 136 30 0.025 0.025 CD cord-258172-p54j4zzo 136 31 ) ) -RRB- cord-258172-p54j4zzo 136 32 , , , cord-258172-p54j4zzo 136 33 visceral visceral JJ cord-258172-p54j4zzo 136 34 adipose adipose JJ cord-258172-p54j4zzo 136 35 tissue tissue NN cord-258172-p54j4zzo 136 36 of of IN cord-258172-p54j4zzo 136 37 omentum omentum NN cord-258172-p54j4zzo 136 38 ( ( -LRB- cord-258172-p54j4zzo 136 39 p p NN cord-258172-p54j4zzo 136 40 = = SYM cord-258172-p54j4zzo 136 41 0.026 0.026 CD cord-258172-p54j4zzo 136 42 ) ) -RRB- cord-258172-p54j4zzo 136 43 , , , cord-258172-p54j4zzo 136 44 sun sun NN cord-258172-p54j4zzo 136 45 exposed expose VBD cord-258172-p54j4zzo 136 46 skin skin NN cord-258172-p54j4zzo 136 47 ( ( -LRB- cord-258172-p54j4zzo 136 48 p p NN cord-258172-p54j4zzo 136 49 = = SYM cord-258172-p54j4zzo 136 50 0.027 0.027 CD cord-258172-p54j4zzo 136 51 ) ) -RRB- cord-258172-p54j4zzo 136 52 , , , cord-258172-p54j4zzo 136 53 whole whole JJ cord-258172-p54j4zzo 136 54 blood blood NN cord-258172-p54j4zzo 136 55 ( ( -LRB- cord-258172-p54j4zzo 136 56 p p NN cord-258172-p54j4zzo 136 57 = = SYM cord-258172-p54j4zzo 136 58 0.032 0.032 CD cord-258172-p54j4zzo 136 59 ) ) -RRB- cord-258172-p54j4zzo 136 60 , , , cord-258172-p54j4zzo 136 61 and and CC cord-258172-p54j4zzo 136 62 bladder bladder NN cord-258172-p54j4zzo 136 63 ( ( -LRB- cord-258172-p54j4zzo 136 64 p p NN cord-258172-p54j4zzo 136 65 = = SYM cord-258172-p54j4zzo 136 66 0.042 0.042 CD cord-258172-p54j4zzo 136 67 ) ) -RRB- cord-258172-p54j4zzo 136 68 ; ; : cord-258172-p54j4zzo 136 69 while while IN cord-258172-p54j4zzo 136 70 increased increase VBD cord-258172-p54j4zzo 136 71 in in IN cord-258172-p54j4zzo 136 72 coronary coronary JJ cord-258172-p54j4zzo 136 73 artery artery NN cord-258172-p54j4zzo 136 74 ( ( -LRB- cord-258172-p54j4zzo 136 75 p p NN cord-258172-p54j4zzo 136 76 = = SYM cord-258172-p54j4zzo 136 77 0.015 0.015 CD cord-258172-p54j4zzo 136 78 ) ) -RRB- cord-258172-p54j4zzo 136 79 . . . cord-258172-p54j4zzo 137 1 In in IN cord-258172-p54j4zzo 137 2 females female NNS cord-258172-p54j4zzo 137 3 , , , cord-258172-p54j4zzo 137 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 137 5 expression expression NN cord-258172-p54j4zzo 137 6 was be VBD cord-258172-p54j4zzo 137 7 lower low JJR cord-258172-p54j4zzo 137 8 in in IN cord-258172-p54j4zzo 137 9 the the DT cord-258172-p54j4zzo 137 10 � � CD cord-258172-p54j4zzo 137 11 50 50 CD cord-258172-p54j4zzo 137 12 age age NN cord-258172-p54j4zzo 137 13 group group NN cord-258172-p54j4zzo 137 14 in in IN cord-258172-p54j4zzo 137 15 whole whole JJ cord-258172-p54j4zzo 137 16 blood blood NN cord-258172-p54j4zzo 138 1 ( ( -LRB- cord-258172-p54j4zzo 138 2 p p NN cord-258172-p54j4zzo 138 3 = = SYM cord-258172-p54j4zzo 138 4 0.005 0.005 CD cord-258172-p54j4zzo 138 5 ) ) -RRB- cord-258172-p54j4zzo 138 6 and and CC cord-258172-p54j4zzo 138 7 sun sun NN cord-258172-p54j4zzo 138 8 exposed expose VBD cord-258172-p54j4zzo 138 9 skin skin NN cord-258172-p54j4zzo 138 10 ( ( -LRB- cord-258172-p54j4zzo 138 11 p p NN cord-258172-p54j4zzo 138 12 = = SYM cord-258172-p54j4zzo 138 13 0.049 0.049 CD cord-258172-p54j4zzo 138 14 ) ) -RRB- cord-258172-p54j4zzo 138 15 ; ; : cord-258172-p54j4zzo 138 16 and and CC cord-258172-p54j4zzo 138 17 higher high JJR cord-258172-p54j4zzo 138 18 in in IN cord-258172-p54j4zzo 138 19 esophagus esophagus NN cord-258172-p54j4zzo 138 20 ( ( -LRB- cord-258172-p54j4zzo 138 21 p p NN cord-258172-p54j4zzo 138 22 = = SYM cord-258172-p54j4zzo 138 23 0.007 0.007 CD cord-258172-p54j4zzo 138 24 ) ) -RRB- cord-258172-p54j4zzo 138 25 and and CC cord-258172-p54j4zzo 138 26 terminal terminal JJ cord-258172-p54j4zzo 138 27 ileum ileum NN cord-258172-p54j4zzo 138 28 ( ( -LRB- cord-258172-p54j4zzo 138 29 p p NN cord-258172-p54j4zzo 138 30 = = SYM cord-258172-p54j4zzo 138 31 0.022 0.022 CD cord-258172-p54j4zzo 138 32 ) ) -RRB- cord-258172-p54j4zzo 138 33 . . . cord-258172-p54j4zzo 139 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 139 2 mRNA mrna NN cord-258172-p54j4zzo 139 3 levels level NNS cord-258172-p54j4zzo 139 4 largely largely RB cord-258172-p54j4zzo 139 5 overlapped overlap VBN cord-258172-p54j4zzo 139 6 between between IN cord-258172-p54j4zzo 139 7 male male JJ cord-258172-p54j4zzo 139 8 and and CC cord-258172-p54j4zzo 139 9 female female JJ cord-258172-p54j4zzo 139 10 sexes sex NNS cord-258172-p54j4zzo 139 11 as as IN cord-258172-p54j4zzo 139 12 shown show VBN cord-258172-p54j4zzo 139 13 in in IN cord-258172-p54j4zzo 139 14 Fig Fig NNP cord-258172-p54j4zzo 139 15 7 7 CD cord-258172-p54j4zzo 139 16 . . . cord-258172-p54j4zzo 140 1 In in IN cord-258172-p54j4zzo 140 2 the the DT cord-258172-p54j4zzo 140 3 lung lung NN cord-258172-p54j4zzo 140 4 , , , cord-258172-p54j4zzo 140 5 no no DT cord-258172-p54j4zzo 140 6 statistically statistically RB cord-258172-p54j4zzo 140 7 significant significant JJ cord-258172-p54j4zzo 140 8 difference difference NN cord-258172-p54j4zzo 140 9 was be VBD cord-258172-p54j4zzo 140 10 observed observe VBN cord-258172-p54j4zzo 140 11 in in IN cord-258172-p54j4zzo 140 12 the the DT cord-258172-p54j4zzo 140 13 expression expression NN cord-258172-p54j4zzo 140 14 levels level NNS cord-258172-p54j4zzo 140 15 between between IN cord-258172-p54j4zzo 140 16 the the DT cord-258172-p54j4zzo 140 17 male male JJ cord-258172-p54j4zzo 140 18 and and CC cord-258172-p54j4zzo 140 19 female female JJ cord-258172-p54j4zzo 140 20 subjects subject NNS cord-258172-p54j4zzo 140 21 ( ( -LRB- cord-258172-p54j4zzo 140 22 p p NN cord-258172-p54j4zzo 140 23 = = SYM cord-258172-p54j4zzo 140 24 0.908 0.908 CD cord-258172-p54j4zzo 140 25 ) ) -RRB- cord-258172-p54j4zzo 140 26 . . . cord-258172-p54j4zzo 141 1 Statistically statistically RB cord-258172-p54j4zzo 141 2 significant significant JJ cord-258172-p54j4zzo 141 3 differences difference NNS cord-258172-p54j4zzo 141 4 were be VBD cord-258172-p54j4zzo 141 5 observed observe VBN cord-258172-p54j4zzo 141 6 in in IN cord-258172-p54j4zzo 141 7 the the DT cord-258172-p54j4zzo 141 8 adipose adipose JJ cord-258172-p54j4zzo 141 9 tissue tissue NN cord-258172-p54j4zzo 141 10 ( ( -LRB- cord-258172-p54j4zzo 141 11 p p NN cord-258172-p54j4zzo 141 12 = = SYM cord-258172-p54j4zzo 141 13 0.0001 0.0001 CD cord-258172-p54j4zzo 141 14 ) ) -RRB- cord-258172-p54j4zzo 141 15 , , , cord-258172-p54j4zzo 141 16 whole whole JJ cord-258172-p54j4zzo 141 17 blood blood NN cord-258172-p54j4zzo 141 18 ( ( -LRB- cord-258172-p54j4zzo 141 19 p p NN cord-258172-p54j4zzo 141 20 = = SYM cord-258172-p54j4zzo 141 21 0.0002 0.0002 CD cord-258172-p54j4zzo 141 22 ) ) -RRB- cord-258172-p54j4zzo 141 23 , , , cord-258172-p54j4zzo 141 24 amygdala amygdala NNP cord-258172-p54j4zzo 141 25 ( ( -LRB- cord-258172-p54j4zzo 141 26 p p NN cord-258172-p54j4zzo 141 27 = = SYM cord-258172-p54j4zzo 141 28 0.0006 0.0006 CD cord-258172-p54j4zzo 141 29 ) ) -RRB- cord-258172-p54j4zzo 141 30 , , , cord-258172-p54j4zzo 141 31 transverse transverse JJ cord-258172-p54j4zzo 141 32 colon colon NN cord-258172-p54j4zzo 141 33 ( ( -LRB- cord-258172-p54j4zzo 141 34 p p NN cord-258172-p54j4zzo 141 35 = = SYM cord-258172-p54j4zzo 141 36 0.0008 0.0008 CD cord-258172-p54j4zzo 141 37 ) ) -RRB- cord-258172-p54j4zzo 141 38 , , , cord-258172-p54j4zzo 141 39 Data Data NNP cord-258172-p54j4zzo 141 40 is be VBZ cord-258172-p54j4zzo 141 41 from from IN cord-258172-p54j4zzo 141 42 GEO GEO NNP cord-258172-p54j4zzo 141 43 dataset dataset NN cord-258172-p54j4zzo 141 44 GSE92332 GSE92332 NNP cord-258172-p54j4zzo 141 45 [ [ -LRB- cord-258172-p54j4zzo 141 46 52 52 CD cord-258172-p54j4zzo 141 47 ] ] -RRB- cord-258172-p54j4zzo 141 48 . . . cord-258172-p54j4zzo 142 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 142 2 mRNA mrna NN cord-258172-p54j4zzo 142 3 expression expression NN cord-258172-p54j4zzo 142 4 as as IN cord-258172-p54j4zzo 142 5 normalized normalize VBN cord-258172-p54j4zzo 142 6 , , , cord-258172-p54j4zzo 142 7 batch batch NN cord-258172-p54j4zzo 142 8 - - HYPH cord-258172-p54j4zzo 142 9 corrected correct VBN cord-258172-p54j4zzo 142 10 counts count NNS cord-258172-p54j4zzo 142 11 is be VBZ cord-258172-p54j4zzo 142 12 shown show VBN cord-258172-p54j4zzo 142 13 for for IN cord-258172-p54j4zzo 142 14 comparison comparison NN cord-258172-p54j4zzo 142 15 in in IN cord-258172-p54j4zzo 142 16 upper upper JJ cord-258172-p54j4zzo 142 17 panel panel NN cord-258172-p54j4zzo 142 18 . . . cord-258172-p54j4zzo 143 1 The the DT cord-258172-p54j4zzo 143 2 force force NN cord-258172-p54j4zzo 143 3 directed direct VBD cord-258172-p54j4zzo 143 4 layout layout NN cord-258172-p54j4zzo 143 5 plot plot NN cord-258172-p54j4zzo 143 6 was be VBD cord-258172-p54j4zzo 143 7 computed compute VBN cord-258172-p54j4zzo 143 8 and and CC cord-258172-p54j4zzo 143 9 visualized visualize VBN cord-258172-p54j4zzo 143 10 in in IN cord-258172-p54j4zzo 143 11 ScanPy scanpy CD cord-258172-p54j4zzo 143 12 [ [ -LRB- cord-258172-p54j4zzo 143 13 54 54 CD cord-258172-p54j4zzo 143 14 ] ] -RRB- cord-258172-p54j4zzo 143 15 . . . cord-258172-p54j4zzo 144 1 For for IN cord-258172-p54j4zzo 144 2 each each DT cord-258172-p54j4zzo 144 3 cell cell NN cord-258172-p54j4zzo 144 4 type type NN cord-258172-p54j4zzo 144 5 the the DT cord-258172-p54j4zzo 144 6 ratio ratio NN cord-258172-p54j4zzo 144 7 of of IN cord-258172-p54j4zzo 144 8 cells cell NNS cord-258172-p54j4zzo 144 9 expressing express VBG cord-258172-p54j4zzo 144 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 144 11 is be VBZ cord-258172-p54j4zzo 144 12 presented present VBN cord-258172-p54j4zzo 144 13 in in IN cord-258172-p54j4zzo 144 14 addition addition NN cord-258172-p54j4zzo 144 15 to to IN cord-258172-p54j4zzo 144 16 a a DT cord-258172-p54j4zzo 144 17 stacked stack VBN cord-258172-p54j4zzo 144 18 barplot barplot NN cord-258172-p54j4zzo 144 19 of of IN cord-258172-p54j4zzo 144 20 the the DT cord-258172-p54j4zzo 144 21 relative relative JJ cord-258172-p54j4zzo 144 22 cell cell NN cord-258172-p54j4zzo 144 23 type type NN cord-258172-p54j4zzo 144 24 frequencies frequency NNS cord-258172-p54j4zzo 144 25 in in IN cord-258172-p54j4zzo 144 26 the the DT cord-258172-p54j4zzo 144 27 whole whole JJ cord-258172-p54j4zzo 144 28 dataset dataset NN cord-258172-p54j4zzo 144 29 . . . cord-258172-p54j4zzo 144 30 https://doi.org/10.1371/journal.pone.0240647.g005 https://doi.org/10.1371/journal.pone.0240647.g005 ADD cord-258172-p54j4zzo 145 1 PLOS PLOS NNP cord-258172-p54j4zzo 146 1 ONE one CD cord-258172-p54j4zzo 146 2 muscle muscle NN cord-258172-p54j4zzo 146 3 layer layer NN cord-258172-p54j4zzo 146 4 of of IN cord-258172-p54j4zzo 146 5 esophagus esophagus NN cord-258172-p54j4zzo 146 6 ( ( -LRB- cord-258172-p54j4zzo 146 7 p p NN cord-258172-p54j4zzo 146 8 = = SYM cord-258172-p54j4zzo 146 9 0.002 0.002 CD cord-258172-p54j4zzo 146 10 ) ) -RRB- cord-258172-p54j4zzo 146 11 , , , cord-258172-p54j4zzo 146 12 left leave VBD cord-258172-p54j4zzo 146 13 ventricle ventricle NN cord-258172-p54j4zzo 146 14 of of IN cord-258172-p54j4zzo 146 15 heart heart NN cord-258172-p54j4zzo 146 16 ( ( -LRB- cord-258172-p54j4zzo 146 17 p p NN cord-258172-p54j4zzo 146 18 = = SYM cord-258172-p54j4zzo 146 19 0.005 0.005 CD cord-258172-p54j4zzo 146 20 ) ) -RRB- cord-258172-p54j4zzo 146 21 , , , cord-258172-p54j4zzo 146 22 Epstein Epstein NNP cord-258172-p54j4zzo 146 23 - - HYPH cord-258172-p54j4zzo 146 24 Barr Barr NNP cord-258172-p54j4zzo 146 25 virus virus NN cord-258172-p54j4zzo 146 26 - - HYPH cord-258172-p54j4zzo 146 27 transformed transform VBN cord-258172-p54j4zzo 146 28 lymphocytes lymphocyte NNS cord-258172-p54j4zzo 146 29 ( ( -LRB- cord-258172-p54j4zzo 146 30 p p NN cord-258172-p54j4zzo 146 31 = = SYM cord-258172-p54j4zzo 146 32 0.015 0.015 CD cord-258172-p54j4zzo 146 33 ) ) -RRB- cord-258172-p54j4zzo 146 34 , , , cord-258172-p54j4zzo 146 35 and and CC cord-258172-p54j4zzo 146 36 esophagus esophagus NN cord-258172-p54j4zzo 146 37 - - HYPH cord-258172-p54j4zzo 146 38 gastroesophageal gastroesophageal NN cord-258172-p54j4zzo 146 39 junction junction NN cord-258172-p54j4zzo 146 40 ( ( -LRB- cord-258172-p54j4zzo 146 41 p p NN cord-258172-p54j4zzo 146 42 = = SYM cord-258172-p54j4zzo 146 43 0.024 0.024 CD cord-258172-p54j4zzo 146 44 ) ) -RRB- cord-258172-p54j4zzo 146 45 . . . cord-258172-p54j4zzo 147 1 Notably notably RB cord-258172-p54j4zzo 147 2 , , , cord-258172-p54j4zzo 147 3 there there EX cord-258172-p54j4zzo 147 4 was be VBD cord-258172-p54j4zzo 147 5 no no DT cord-258172-p54j4zzo 147 6 clear clear JJ cord-258172-p54j4zzo 147 7 sex sex NN cord-258172-p54j4zzo 147 8 - - HYPH cord-258172-p54j4zzo 147 9 specific specific JJ cord-258172-p54j4zzo 147 10 trend trend NN cord-258172-p54j4zzo 147 11 pointing point VBG cord-258172-p54j4zzo 147 12 to to IN cord-258172-p54j4zzo 147 13 one one CD cord-258172-p54j4zzo 147 14 direction direction NN cord-258172-p54j4zzo 147 15 in in IN cord-258172-p54j4zzo 147 16 all all PDT cord-258172-p54j4zzo 147 17 these these DT cord-258172-p54j4zzo 147 18 cases case NNS cord-258172-p54j4zzo 147 19 . . . cord-258172-p54j4zzo 148 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 148 2 mRNA mrna NN cord-258172-p54j4zzo 148 3 expression expression NN cord-258172-p54j4zzo 148 4 levels level NNS cord-258172-p54j4zzo 148 5 in in IN cord-258172-p54j4zzo 148 6 all all DT cord-258172-p54j4zzo 148 7 studied study VBN cord-258172-p54j4zzo 148 8 tissues tissue NNS cord-258172-p54j4zzo 148 9 sorted sort VBD cord-258172-p54j4zzo 148 10 according accord VBG cord-258172-p54j4zzo 148 11 to to IN cord-258172-p54j4zzo 148 12 subjects´gender subjects´gender ADD cord-258172-p54j4zzo 148 13 are be VBP cord-258172-p54j4zzo 148 14 shown show VBN cord-258172-p54j4zzo 148 15 in in IN cord-258172-p54j4zzo 148 16 S4 S4 NNP cord-258172-p54j4zzo 148 17 Table Table NNP cord-258172-p54j4zzo 148 18 . . . cord-258172-p54j4zzo 149 1 Proximal proximal JJ cord-258172-p54j4zzo 149 2 promoter promoter NN cord-258172-p54j4zzo 149 3 contains contain VBZ cord-258172-p54j4zzo 149 4 putative putative JJ cord-258172-p54j4zzo 149 5 TFBSs tfbs NNS cord-258172-p54j4zzo 149 6 for for IN cord-258172-p54j4zzo 149 7 ileum ileum NN cord-258172-p54j4zzo 149 8 , , , cord-258172-p54j4zzo 149 9 colon colon NN cord-258172-p54j4zzo 149 10 , , , cord-258172-p54j4zzo 149 11 and and CC cord-258172-p54j4zzo 149 12 kidney kidney NN cord-258172-p54j4zzo 149 13 expression expression NN cord-258172-p54j4zzo 150 1 TFBS tfbs NN cord-258172-p54j4zzo 150 2 analysis analysis NN cord-258172-p54j4zzo 150 3 of of IN cord-258172-p54j4zzo 150 4 the the DT cord-258172-p54j4zzo 150 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 150 6 intestinal intestinal JJ cord-258172-p54j4zzo 150 7 transcript transcript NN cord-258172-p54j4zzo 150 8 promoter promoter NN cord-258172-p54j4zzo 150 9 ( ( -LRB- cord-258172-p54j4zzo 150 10 ENST00000252519 ENST00000252519 NNP cord-258172-p54j4zzo 150 11 ) ) -RRB- cord-258172-p54j4zzo 150 12 revealed reveal VBD cord-258172-p54j4zzo 150 13 several several JJ cord-258172-p54j4zzo 150 14 candidate candidate NN cord-258172-p54j4zzo 150 15 binding bind VBG cord-258172-p54j4zzo 150 16 sites site NNS cord-258172-p54j4zzo 150 17 which which WDT cord-258172-p54j4zzo 150 18 occur occur VBP cord-258172-p54j4zzo 150 19 in in IN cord-258172-p54j4zzo 150 20 a a DT cord-258172-p54j4zzo 150 21 cluster cluster NN cord-258172-p54j4zzo 150 22 extending extend VBG cord-258172-p54j4zzo 150 23 from from IN cord-258172-p54j4zzo 150 24 400 400 CD cord-258172-p54j4zzo 150 25 bp bp NNP cord-258172-p54j4zzo 150 26 upstream upstream RB cord-258172-p54j4zzo 150 27 of of IN cord-258172-p54j4zzo 150 28 the the DT cord-258172-p54j4zzo 150 29 Effect effect NN cord-258172-p54j4zzo 150 30 of of IN cord-258172-p54j4zzo 150 31 age age NN cord-258172-p54j4zzo 150 32 on on IN cord-258172-p54j4zzo 150 33 ACE2 ACE2 NNP cord-258172-p54j4zzo 150 34 mRNA mRNA NNP cord-258172-p54j4zzo 150 35 expression expression NN cord-258172-p54j4zzo 150 36 levels level NNS cord-258172-p54j4zzo 150 37 . . . cord-258172-p54j4zzo 151 1 Data Data NNP cord-258172-p54j4zzo 151 2 is be VBZ cord-258172-p54j4zzo 151 3 extracted extract VBN cord-258172-p54j4zzo 151 4 from from IN cord-258172-p54j4zzo 151 5 the the DT cord-258172-p54j4zzo 151 6 GTEx gtex NN cord-258172-p54j4zzo 151 7 dataset dataset NN cord-258172-p54j4zzo 151 8 as as IN cord-258172-p54j4zzo 151 9 TPM TPM NNP cord-258172-p54j4zzo 151 10 . . . cord-258172-p54j4zzo 152 1 In in IN cord-258172-p54j4zzo 152 2 these these DT cord-258172-p54j4zzo 152 3 organs organ NNS cord-258172-p54j4zzo 152 4 , , , cord-258172-p54j4zzo 152 5 ANOVA ANOVA NNP cord-258172-p54j4zzo 152 6 revealed reveal VBD cord-258172-p54j4zzo 152 7 significant significant JJ cord-258172-p54j4zzo 152 8 differences difference NNS cord-258172-p54j4zzo 152 9 between between IN cord-258172-p54j4zzo 152 10 age age NN cord-258172-p54j4zzo 152 11 categories category NNS cord-258172-p54j4zzo 152 12 in in IN cord-258172-p54j4zzo 152 13 tibial tibial JJ cord-258172-p54j4zzo 152 14 nerve nerve NN cord-258172-p54j4zzo 152 15 ( ( -LRB- cord-258172-p54j4zzo 152 16 p p NN cord-258172-p54j4zzo 152 17 = = SYM cord-258172-p54j4zzo 152 18 8.58 8.58 CD cord-258172-p54j4zzo 152 19 x x SYM cord-258172-p54j4zzo 152 20 10 10 CD cord-258172-p54j4zzo 152 21 −6 −6 NNP cord-258172-p54j4zzo 152 22 ) ) -RRB- cord-258172-p54j4zzo 152 23 , , , cord-258172-p54j4zzo 152 24 minor minor JJ cord-258172-p54j4zzo 152 25 salivary salivary NN cord-258172-p54j4zzo 152 26 gland gland NN cord-258172-p54j4zzo 152 27 ( ( -LRB- cord-258172-p54j4zzo 152 28 p p NN cord-258172-p54j4zzo 152 29 = = SYM cord-258172-p54j4zzo 152 30 0.002 0.002 CD cord-258172-p54j4zzo 152 31 ) ) -RRB- cord-258172-p54j4zzo 152 32 , , , cord-258172-p54j4zzo 152 33 and and CC cord-258172-p54j4zzo 152 34 whole whole JJ cord-258172-p54j4zzo 152 35 blood blood NN cord-258172-p54j4zzo 152 36 ( ( -LRB- cord-258172-p54j4zzo 152 37 p p NN cord-258172-p54j4zzo 152 38 = = SYM cord-258172-p54j4zzo 152 39 0.005 0.005 CD cord-258172-p54j4zzo 152 40 ) ) -RRB- cord-258172-p54j4zzo 152 41 . . . cord-258172-p54j4zzo 153 1 In in IN cord-258172-p54j4zzo 153 2 other other JJ cord-258172-p54j4zzo 153 3 tissues tissue NNS cord-258172-p54j4zzo 153 4 , , , cord-258172-p54j4zzo 153 5 the the DT cord-258172-p54j4zzo 153 6 differences difference NNS cord-258172-p54j4zzo 153 7 did do VBD cord-258172-p54j4zzo 153 8 not not RB cord-258172-p54j4zzo 153 9 reach reach VB cord-258172-p54j4zzo 153 10 statistical statistical JJ cord-258172-p54j4zzo 153 11 significance significance NN cord-258172-p54j4zzo 153 12 . . . cord-258172-p54j4zzo 154 1 The the DT cord-258172-p54j4zzo 154 2 highest high JJS cord-258172-p54j4zzo 154 3 TPM TPM NNP cord-258172-p54j4zzo 154 4 values value NNS cord-258172-p54j4zzo 154 5 are be VBP cord-258172-p54j4zzo 154 6 seen see VBN cord-258172-p54j4zzo 154 7 in in IN cord-258172-p54j4zzo 154 8 the the DT cord-258172-p54j4zzo 154 9 small small JJ cord-258172-p54j4zzo 154 10 intestine intestine NN cord-258172-p54j4zzo 154 11 , , , cord-258172-p54j4zzo 154 12 testis testis NN cord-258172-p54j4zzo 154 13 , , , cord-258172-p54j4zzo 154 14 and and CC cord-258172-p54j4zzo 154 15 kidney kidney NN cord-258172-p54j4zzo 154 16 . . . cord-258172-p54j4zzo 155 1 https://doi.org/10.1371/journal.pone.0240647.g006 https://doi.org/10.1371/journal.pone.0240647.g006 NNP cord-258172-p54j4zzo 155 2 transcription transcription NN cord-258172-p54j4zzo 155 3 start start NN cord-258172-p54j4zzo 155 4 site site NN cord-258172-p54j4zzo 155 5 ; ; : cord-258172-p54j4zzo 155 6 CDX2 CDX2 NNP cord-258172-p54j4zzo 155 7 , , , cord-258172-p54j4zzo 155 8 HNF1A hnf1a CD cord-258172-p54j4zzo 155 9 , , , cord-258172-p54j4zzo 155 10 FOXA1 FOXA1 NNP cord-258172-p54j4zzo 155 11 , , , cord-258172-p54j4zzo 155 12 SOX4 SOX4 NNPS cord-258172-p54j4zzo 155 13 , , , cord-258172-p54j4zzo 155 14 TP63 TP63 NNP cord-258172-p54j4zzo 155 15 , , , cord-258172-p54j4zzo 155 16 HNF4A hnf4a UH cord-258172-p54j4zzo 155 17 , , , cord-258172-p54j4zzo 155 18 DUX4 DUX4 NNP cord-258172-p54j4zzo 155 19 , , , cord-258172-p54j4zzo 155 20 FOXA2 FOXA2 NNP cord-258172-p54j4zzo 155 21 , , , cord-258172-p54j4zzo 155 22 NR2F6 NR2F6 NNP cord-258172-p54j4zzo 155 23 , , , cord-258172-p54j4zzo 155 24 and and CC cord-258172-p54j4zzo 155 25 SOX11 SOX11 NNP cord-258172-p54j4zzo 155 26 ( ( -LRB- cord-258172-p54j4zzo 155 27 Fig Fig NNP cord-258172-p54j4zzo 155 28 8A 8a NN cord-258172-p54j4zzo 155 29 ) ) -RRB- cord-258172-p54j4zzo 155 30 . . . cord-258172-p54j4zzo 156 1 These these DT cord-258172-p54j4zzo 156 2 predicted predict VBN cord-258172-p54j4zzo 156 3 sites site NNS cord-258172-p54j4zzo 156 4 overlap overlap VBP cord-258172-p54j4zzo 156 5 an an DT cord-258172-p54j4zzo 156 6 evolutionarily evolutionarily RB cord-258172-p54j4zzo 156 7 conserved conserve VBN cord-258172-p54j4zzo 156 8 region region NN cord-258172-p54j4zzo 156 9 in in IN cord-258172-p54j4zzo 156 10 mammals mammal NNS cord-258172-p54j4zzo 156 11 and and CC cord-258172-p54j4zzo 156 12 are be VBP cord-258172-p54j4zzo 156 13 proximal proximal JJ cord-258172-p54j4zzo 156 14 to to IN cord-258172-p54j4zzo 156 15 several several JJ cord-258172-p54j4zzo 156 16 ATAC ATAC NNP cord-258172-p54j4zzo 156 17 - - HYPH cord-258172-p54j4zzo 156 18 Seq Seq NNP cord-258172-p54j4zzo 156 19 peaks peak NNS cord-258172-p54j4zzo 156 20 . . . cord-258172-p54j4zzo 157 1 In in IN cord-258172-p54j4zzo 157 2 several several JJ cord-258172-p54j4zzo 157 3 tissues tissue NNS cord-258172-p54j4zzo 157 4 these these DT cord-258172-p54j4zzo 157 5 TFs tf NNS cord-258172-p54j4zzo 157 6 are be VBP cord-258172-p54j4zzo 157 7 found find VBN cord-258172-p54j4zzo 157 8 to to TO cord-258172-p54j4zzo 157 9 be be VB cord-258172-p54j4zzo 157 10 highly highly RB cord-258172-p54j4zzo 157 11 positively positively RB cord-258172-p54j4zzo 157 12 correlated correlate VBN cord-258172-p54j4zzo 157 13 ( ( -LRB- cord-258172-p54j4zzo 157 14 > > NFP cord-258172-p54j4zzo 157 15 0.7 0.7 CD cord-258172-p54j4zzo 157 16 ) ) -RRB- cord-258172-p54j4zzo 157 17 with with IN cord-258172-p54j4zzo 157 18 expression expression NN cord-258172-p54j4zzo 157 19 of of IN cord-258172-p54j4zzo 157 20 ACE2 ACE2 NNP cord-258172-p54j4zzo 157 21 , , , cord-258172-p54j4zzo 157 22 as as IN cord-258172-p54j4zzo 157 23 determined determine VBN cord-258172-p54j4zzo 157 24 using use VBG cord-258172-p54j4zzo 157 25 RNA RNA NNP cord-258172-p54j4zzo 157 26 - - HYPH cord-258172-p54j4zzo 157 27 Seq seq NN cord-258172-p54j4zzo 157 28 gene gene NN cord-258172-p54j4zzo 157 29 expression expression NN cord-258172-p54j4zzo 157 30 values value NNS cord-258172-p54j4zzo 157 31 from from IN cord-258172-p54j4zzo 157 32 the the DT cord-258172-p54j4zzo 157 33 GTEX GTEX NNP cord-258172-p54j4zzo 157 34 dataset dataset NN cord-258172-p54j4zzo 157 35 : : : cord-258172-p54j4zzo 157 36 CDX2 CDX2 NNP cord-258172-p54j4zzo 157 37 ( ( -LRB- cord-258172-p54j4zzo 157 38 colon colon NN cord-258172-p54j4zzo 157 39 , , , cord-258172-p54j4zzo 157 40 terminal terminal JJ cord-258172-p54j4zzo 157 41 ileum ileum NN cord-258172-p54j4zzo 157 42 ) ) -RRB- cord-258172-p54j4zzo 157 43 , , , cord-258172-p54j4zzo 157 44 HNF1A hnf1a CD cord-258172-p54j4zzo 157 45 ( ( -LRB- cord-258172-p54j4zzo 157 46 colon colon NN cord-258172-p54j4zzo 157 47 , , , cord-258172-p54j4zzo 157 48 kidney kidney NN cord-258172-p54j4zzo 157 49 , , , cord-258172-p54j4zzo 157 50 terminal terminal JJ cord-258172-p54j4zzo 157 51 ileum ileum NN cord-258172-p54j4zzo 157 52 ) ) -RRB- cord-258172-p54j4zzo 157 53 , , , cord-258172-p54j4zzo 157 54 FOXA1 FOXA1 NNP cord-258172-p54j4zzo 157 55 ( ( -LRB- cord-258172-p54j4zzo 157 56 cervix cervix NN cord-258172-p54j4zzo 157 57 , , , cord-258172-p54j4zzo 157 58 colon colon NN cord-258172-p54j4zzo 157 59 , , , cord-258172-p54j4zzo 157 60 terminal terminal JJ cord-258172-p54j4zzo 157 61 ileum ileum NN cord-258172-p54j4zzo 157 62 ) ) -RRB- cord-258172-p54j4zzo 157 63 , , , cord-258172-p54j4zzo 157 64 HNF4A HNF4A : cord-258172-p54j4zzo 157 65 ( ( -LRB- cord-258172-p54j4zzo 157 66 colon colon NN cord-258172-p54j4zzo 157 67 , , , cord-258172-p54j4zzo 157 68 terminal terminal JJ cord-258172-p54j4zzo 157 69 ileum ileum NN cord-258172-p54j4zzo 157 70 ) ) -RRB- cord-258172-p54j4zzo 157 71 , , , cord-258172-p54j4zzo 157 72 FOXA2 FOXA2 NNP cord-258172-p54j4zzo 157 73 ( ( -LRB- cord-258172-p54j4zzo 157 74 colon colon NN cord-258172-p54j4zzo 157 75 , , , cord-258172-p54j4zzo 157 76 kidney kidney NN cord-258172-p54j4zzo 157 77 ) ) -RRB- cord-258172-p54j4zzo 157 78 , , , cord-258172-p54j4zzo 157 79 NR2F6 nr2f6 NN cord-258172-p54j4zzo 157 80 ( ( -LRB- cord-258172-p54j4zzo 157 81 colon colon NN cord-258172-p54j4zzo 157 82 , , , cord-258172-p54j4zzo 157 83 kidney kidney NN cord-258172-p54j4zzo 157 84 , , , cord-258172-p54j4zzo 157 85 terminal terminal JJ cord-258172-p54j4zzo 157 86 ileum ileum NN cord-258172-p54j4zzo 157 87 ) ) -RRB- cord-258172-p54j4zzo 157 88 , , , cord-258172-p54j4zzo 157 89 and and CC cord-258172-p54j4zzo 157 90 SOX11 SOX11 NNP cord-258172-p54j4zzo 157 91 ( ( -LRB- cord-258172-p54j4zzo 157 92 kidney kidney NN cord-258172-p54j4zzo 157 93 ) ) -RRB- cord-258172-p54j4zzo 157 94 . . . cord-258172-p54j4zzo 158 1 In in IN cord-258172-p54j4zzo 158 2 addition addition NN cord-258172-p54j4zzo 158 3 , , , cord-258172-p54j4zzo 158 4 two two CD cord-258172-p54j4zzo 158 5 of of IN cord-258172-p54j4zzo 158 6 the the DT cord-258172-p54j4zzo 158 7 TFs tf NNS cord-258172-p54j4zzo 158 8 are be VBP cord-258172-p54j4zzo 158 9 highly highly RB cord-258172-p54j4zzo 158 10 negatively negatively RB cord-258172-p54j4zzo 158 11 correlated correlate VBN cord-258172-p54j4zzo 158 12 with with IN cord-258172-p54j4zzo 158 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 158 14 expression expression NN cord-258172-p54j4zzo 158 15 DUX4 DUX4 NNP cord-258172-p54j4zzo 158 16 ( ( -LRB- cord-258172-p54j4zzo 158 17 kidney kidney NN cord-258172-p54j4zzo 158 18 ) ) -RRB- cord-258172-p54j4zzo 158 19 and and CC cord-258172-p54j4zzo 158 20 FOXA1 FOXA1 NNS cord-258172-p54j4zzo 158 21 ( ( -LRB- cord-258172-p54j4zzo 158 22 kidney kidney NN cord-258172-p54j4zzo 158 23 ) ) -RRB- cord-258172-p54j4zzo 158 24 . . . cord-258172-p54j4zzo 159 1 Full full JJ cord-258172-p54j4zzo 159 2 prediction prediction NN cord-258172-p54j4zzo 159 3 results result NNS cord-258172-p54j4zzo 159 4 are be VBP cord-258172-p54j4zzo 159 5 included include VBN cord-258172-p54j4zzo 159 6 in in IN cord-258172-p54j4zzo 159 7 S5 S5 NNP cord-258172-p54j4zzo 159 8 _SP cord-258172-p54j4zzo 159 9 Table Table NNP cord-258172-p54j4zzo 159 10 and and CC cord-258172-p54j4zzo 159 11 TF TF NNP cord-258172-p54j4zzo 159 12 correlations correlation NNS cord-258172-p54j4zzo 159 13 by by IN cord-258172-p54j4zzo 159 14 tissue tissue NN cord-258172-p54j4zzo 159 15 are be VBP cord-258172-p54j4zzo 159 16 present present JJ cord-258172-p54j4zzo 159 17 in in IN cord-258172-p54j4zzo 159 18 S6 S6 NNP cord-258172-p54j4zzo 159 19 Table Table NNP cord-258172-p54j4zzo 159 20 . . . cord-258172-p54j4zzo 160 1 An an DT cord-258172-p54j4zzo 160 2 expanded expand VBN cord-258172-p54j4zzo 160 3 analysis analysis NN cord-258172-p54j4zzo 160 4 for for IN cord-258172-p54j4zzo 160 5 binding bind VBG cord-258172-p54j4zzo 160 6 sites site NNS cord-258172-p54j4zzo 160 7 of of IN cord-258172-p54j4zzo 160 8 interferon interferon NN cord-258172-p54j4zzo 160 9 - - HYPH cord-258172-p54j4zzo 160 10 stimulation stimulation NN cord-258172-p54j4zzo 160 11 mediating mediate VBG cord-258172-p54j4zzo 160 12 TF TF NNP cord-258172-p54j4zzo 160 13 genes gene NNS cord-258172-p54j4zzo 160 14 in in IN cord-258172-p54j4zzo 160 15 the the DT cord-258172-p54j4zzo 160 16 region region NN cord-258172-p54j4zzo 160 17 1,500 1,500 CD cord-258172-p54j4zzo 160 18 bp bp NNP cord-258172-p54j4zzo 160 19 upstream upstream RB cord-258172-p54j4zzo 160 20 to to IN cord-258172-p54j4zzo 160 21 500 500 CD cord-258172-p54j4zzo 160 22 bp bp NNP cord-258172-p54j4zzo 160 23 downstream downstream NN cord-258172-p54j4zzo 160 24 of of IN cord-258172-p54j4zzo 160 25 the the DT cord-258172-p54j4zzo 160 26 ACE2 ACE2 NNP cord-258172-p54j4zzo 160 27 intestinal intestinal JJ cord-258172-p54j4zzo 160 28 transcript transcript NN cord-258172-p54j4zzo 160 29 's 's POS cord-258172-p54j4zzo 160 30 TSS TSS NNP cord-258172-p54j4zzo 160 31 revealed reveal VBD cord-258172-p54j4zzo 160 32 putative putative JJ cord-258172-p54j4zzo 160 33 binding bind VBG cord-258172-p54j4zzo 160 34 sites site NNS cord-258172-p54j4zzo 160 35 for for IN cord-258172-p54j4zzo 160 36 STAT1 stat1 NN cord-258172-p54j4zzo 160 37 ( ( -LRB- cord-258172-p54j4zzo 160 38 3x 3x CD cord-258172-p54j4zzo 160 39 ) ) -RRB- cord-258172-p54j4zzo 160 40 , , , cord-258172-p54j4zzo 160 41 STAT3 STAT3 NNP cord-258172-p54j4zzo 160 42 ( ( -LRB- cord-258172-p54j4zzo 160 43 4x 4x CD cord-258172-p54j4zzo 160 44 ) ) -RRB- cord-258172-p54j4zzo 160 45 , , , cord-258172-p54j4zzo 160 46 STAT5A STAT5A NNP cord-258172-p54j4zzo 160 47 : : : cord-258172-p54j4zzo 161 1 STAT5B STAT5B NNP cord-258172-p54j4zzo 161 2 dimer dimer NN cord-258172-p54j4zzo 161 3 ( ( -LRB- cord-258172-p54j4zzo 161 4 3x 3x CD cord-258172-p54j4zzo 161 5 ) ) -RRB- cord-258172-p54j4zzo 161 6 , , , cord-258172-p54j4zzo 161 7 STAT4 stat4 NN cord-258172-p54j4zzo 161 8 , , , cord-258172-p54j4zzo 162 1 STAT1 STAT1 NNP cord-258172-p54j4zzo 162 2 : : : cord-258172-p54j4zzo 163 1 STAT2 STAT2 NNS cord-258172-p54j4zzo 163 2 dimer dimer NNP cord-258172-p54j4zzo 163 3 ( ( -LRB- cord-258172-p54j4zzo 163 4 2x 2x CD cord-258172-p54j4zzo 163 5 ) ) -RRB- cord-258172-p54j4zzo 163 6 , , , cord-258172-p54j4zzo 163 7 IRF2 IRF2 NNP cord-258172-p54j4zzo 163 8 , , , cord-258172-p54j4zzo 163 9 IRF3 IRF3 NNP cord-258172-p54j4zzo 163 10 , , , cord-258172-p54j4zzo 163 11 IRF4 IRF4 NNP cord-258172-p54j4zzo 163 12 ( ( -LRB- cord-258172-p54j4zzo 163 13 2x 2x CD cord-258172-p54j4zzo 163 14 ) ) -RRB- cord-258172-p54j4zzo 163 15 , , , cord-258172-p54j4zzo 163 16 IRF5 IRF5 NNP cord-258172-p54j4zzo 163 17 ( ( -LRB- cord-258172-p54j4zzo 163 18 2x 2x CD cord-258172-p54j4zzo 163 19 ) ) -RRB- cord-258172-p54j4zzo 163 20 , , , cord-258172-p54j4zzo 163 21 IRF8 IRF8 NNP cord-258172-p54j4zzo 163 22 ( ( -LRB- cord-258172-p54j4zzo 163 23 3x 3x CD cord-258172-p54j4zzo 163 24 ) ) -RRB- cord-258172-p54j4zzo 163 25 , , , cord-258172-p54j4zzo 163 26 and and CC cord-258172-p54j4zzo 163 27 IRF9 IRF9 NNP cord-258172-p54j4zzo 163 28 ( ( -LRB- cord-258172-p54j4zzo 163 29 S1 S1 NNP cord-258172-p54j4zzo 163 30 Fig Fig NNP cord-258172-p54j4zzo 163 31 ) ) -RRB- cord-258172-p54j4zzo 163 32 . . . cord-258172-p54j4zzo 164 1 Each each DT cord-258172-p54j4zzo 164 2 of of IN cord-258172-p54j4zzo 164 3 these these DT cord-258172-p54j4zzo 164 4 predictions prediction NNS cord-258172-p54j4zzo 164 5 satisfied satisfy VBD cord-258172-p54j4zzo 164 6 a a DT cord-258172-p54j4zzo 164 7 PWM PWM NNP cord-258172-p54j4zzo 164 8 p p NN cord-258172-p54j4zzo 164 9 - - HYPH cord-258172-p54j4zzo 164 10 value value NN cord-258172-p54j4zzo 164 11 threshold threshold NN cord-258172-p54j4zzo 164 12 of of IN cord-258172-p54j4zzo 164 13 < < NNP cord-258172-p54j4zzo 164 14 0.0001 0.0001 CD cord-258172-p54j4zzo 164 15 , , , cord-258172-p54j4zzo 164 16 while while IN cord-258172-p54j4zzo 164 17 only only RB cord-258172-p54j4zzo 164 18 the the DT cord-258172-p54j4zzo 164 19 STAT1 stat1 NN cord-258172-p54j4zzo 164 20 , , , cord-258172-p54j4zzo 164 21 IRF9 IRF9 NNP cord-258172-p54j4zzo 164 22 , , , cord-258172-p54j4zzo 164 23 and and CC cord-258172-p54j4zzo 164 24 IRF8 IRF8 NNP cord-258172-p54j4zzo 164 25 sites site NNS cord-258172-p54j4zzo 164 26 also also RB cord-258172-p54j4zzo 164 27 satisfied satisfy VBD cord-258172-p54j4zzo 164 28 a a DT cord-258172-p54j4zzo 164 29 combined combine VBN cord-258172-p54j4zzo 164 30 affinity affinity NN cord-258172-p54j4zzo 164 31 score score NN cord-258172-p54j4zzo 164 32 p p NN cord-258172-p54j4zzo 164 33 - - HYPH cord-258172-p54j4zzo 164 34 value value NN cord-258172-p54j4zzo 164 35 of of IN cord-258172-p54j4zzo 164 36 < < NNP cord-258172-p54j4zzo 164 37 0.05 0.05 CD cord-258172-p54j4zzo 164 38 . . . cord-258172-p54j4zzo 165 1 Analysis analysis NN cord-258172-p54j4zzo 165 2 of of IN cord-258172-p54j4zzo 165 3 the the DT cord-258172-p54j4zzo 165 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 165 5 lung lung NN cord-258172-p54j4zzo 165 6 transcript transcript NN cord-258172-p54j4zzo 165 7 promoter promoter NN cord-258172-p54j4zzo 165 8 ( ( -LRB- cord-258172-p54j4zzo 165 9 ENST00000427411 ENST00000427411 NNP cord-258172-p54j4zzo 165 10 ) ) -RRB- cord-258172-p54j4zzo 165 11 produced produce VBD cord-258172-p54j4zzo 165 12 putative putative JJ cord-258172-p54j4zzo 165 13 TFBS TFBS NNP cord-258172-p54j4zzo 165 14 predictions prediction NNS cord-258172-p54j4zzo 165 15 for for IN cord-258172-p54j4zzo 165 16 ESRRA ESRRA NNP cord-258172-p54j4zzo 165 17 , , , cord-258172-p54j4zzo 165 18 HNF4A hnf4a UH cord-258172-p54j4zzo 165 19 , , , cord-258172-p54j4zzo 165 20 CDX2 CDX2 NNP cord-258172-p54j4zzo 165 21 , , , cord-258172-p54j4zzo 165 22 CEBPA CEBPA NNP cord-258172-p54j4zzo 165 23 , , , cord-258172-p54j4zzo 165 24 ESRRB ESRRB NNP cord-258172-p54j4zzo 165 25 , , , cord-258172-p54j4zzo 165 26 MEF2B mef2b NN cord-258172-p54j4zzo 165 27 , , , cord-258172-p54j4zzo 165 28 TCF7 TCF7 NNP cord-258172-p54j4zzo 165 29 , , , cord-258172-p54j4zzo 165 30 TCF7L2 TCF7L2 NNP cord-258172-p54j4zzo 165 31 , , , cord-258172-p54j4zzo 165 32 JUN JUN NNP cord-258172-p54j4zzo 165 33 , , , cord-258172-p54j4zzo 165 34 and and CC cord-258172-p54j4zzo 165 35 LEF1 LEF1 NNP cord-258172-p54j4zzo 165 36 ( ( -LRB- cord-258172-p54j4zzo 165 37 Fig Fig NNP cord-258172-p54j4zzo 165 38 8B 8b NN cord-258172-p54j4zzo 165 39 ) ) -RRB- cord-258172-p54j4zzo 165 40 . . . cord-258172-p54j4zzo 166 1 Full full JJ cord-258172-p54j4zzo 166 2 prediction prediction NN cord-258172-p54j4zzo 166 3 results result NNS cord-258172-p54j4zzo 166 4 are be VBP cord-258172-p54j4zzo 166 5 included include VBN cord-258172-p54j4zzo 166 6 in in IN cord-258172-p54j4zzo 166 7 S5 S5 NNP cord-258172-p54j4zzo 166 8 Table Table NNP cord-258172-p54j4zzo 166 9 . . . cord-258172-p54j4zzo 167 1 The the DT cord-258172-p54j4zzo 167 2 predicted predict VBN cord-258172-p54j4zzo 167 3 TFBSs tfbs NNS cord-258172-p54j4zzo 167 4 clustered cluster VBN cord-258172-p54j4zzo 167 5 within within IN cord-258172-p54j4zzo 167 6 200 200 CD cord-258172-p54j4zzo 167 7 base base NN cord-258172-p54j4zzo 167 8 pairs pair NNS cord-258172-p54j4zzo 167 9 of of IN cord-258172-p54j4zzo 167 10 the the DT cord-258172-p54j4zzo 167 11 TSS TSS NNP cord-258172-p54j4zzo 167 12 , , , cord-258172-p54j4zzo 167 13 and and CC cord-258172-p54j4zzo 167 14 overlap overlap VBP cord-258172-p54j4zzo 167 15 with with IN cord-258172-p54j4zzo 167 16 evolutionarily evolutionarily RB cord-258172-p54j4zzo 167 17 conserved conserve VBN cord-258172-p54j4zzo 167 18 regions region NNS cord-258172-p54j4zzo 167 19 , , , cord-258172-p54j4zzo 167 20 TFBS TFBS NNP cord-258172-p54j4zzo 167 21 metaclusters metacluster NNS cord-258172-p54j4zzo 167 22 , , , cord-258172-p54j4zzo 167 23 and and CC cord-258172-p54j4zzo 167 24 ATAC ATAC NNP cord-258172-p54j4zzo 167 25 - - HYPH cord-258172-p54j4zzo 167 26 Seq Seq NNP cord-258172-p54j4zzo 167 27 peaks peak NNS cord-258172-p54j4zzo 167 28 . . . cord-258172-p54j4zzo 168 1 The the DT cord-258172-p54j4zzo 168 2 TFs tf NNS cord-258172-p54j4zzo 168 3 corresponding correspond VBG cord-258172-p54j4zzo 168 4 to to IN cord-258172-p54j4zzo 168 5 predicted predict VBN cord-258172-p54j4zzo 168 6 TFBSs tfbs NNS cord-258172-p54j4zzo 168 7 , , , cord-258172-p54j4zzo 168 8 which which WDT cord-258172-p54j4zzo 168 9 are be VBP cord-258172-p54j4zzo 168 10 positively positively RB cord-258172-p54j4zzo 168 11 correlated correlate VBN cord-258172-p54j4zzo 168 12 ( ( -LRB- cord-258172-p54j4zzo 168 13 > > NFP cord-258172-p54j4zzo 168 14 0.7 0.7 CD cord-258172-p54j4zzo 168 15 ) ) -RRB- cord-258172-p54j4zzo 168 16 with with IN cord-258172-p54j4zzo 168 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 168 18 expression expression NN cord-258172-p54j4zzo 168 19 , , , cord-258172-p54j4zzo 168 20 are be VBP cord-258172-p54j4zzo 168 21 ESRRA ESRRA NNP cord-258172-p54j4zzo 168 22 ( ( -LRB- cord-258172-p54j4zzo 168 23 terminal terminal JJ cord-258172-p54j4zzo 168 24 ileum ileum NN cord-258172-p54j4zzo 168 25 , , , cord-258172-p54j4zzo 168 26 colon colon NN cord-258172-p54j4zzo 168 27 ) ) -RRB- cord-258172-p54j4zzo 168 28 , , , cord-258172-p54j4zzo 168 29 HNF4A HNF4A '' cord-258172-p54j4zzo 169 1 ( ( -LRB- cord-258172-p54j4zzo 169 2 terminal terminal JJ cord-258172-p54j4zzo 169 3 ileum ileum NN cord-258172-p54j4zzo 169 4 , , , cord-258172-p54j4zzo 169 5 colon colon NN cord-258172-p54j4zzo 169 6 ) ) -RRB- cord-258172-p54j4zzo 169 7 , , , cord-258172-p54j4zzo 169 8 CDX2 CDX2 NNP cord-258172-p54j4zzo 169 9 ( ( -LRB- cord-258172-p54j4zzo 169 10 colon colon NN cord-258172-p54j4zzo 169 11 , , , cord-258172-p54j4zzo 169 12 terminal terminal JJ cord-258172-p54j4zzo 169 13 ileum ileum NN cord-258172-p54j4zzo 169 14 ) ) -RRB- cord-258172-p54j4zzo 169 15 , , , cord-258172-p54j4zzo 169 16 CEBPA CEBPA NNP cord-258172-p54j4zzo 169 17 ( ( -LRB- cord-258172-p54j4zzo 169 18 colon colon NN cord-258172-p54j4zzo 169 19 , , , cord-258172-p54j4zzo 169 20 terminal terminal JJ cord-258172-p54j4zzo 169 21 ileum ileum NN cord-258172-p54j4zzo 169 22 ) ) -RRB- cord-258172-p54j4zzo 169 23 , , , cord-258172-p54j4zzo 169 24 ESRRB ESRRB NNP cord-258172-p54j4zzo 169 25 ( ( -LRB- cord-258172-p54j4zzo 169 26 cervix cervix NN cord-258172-p54j4zzo 169 27 ) ) -RRB- cord-258172-p54j4zzo 169 28 , , . cord-258172-p54j4zzo 170 1 TCF7L2 tcf7l2 LS cord-258172-p54j4zzo 170 2 ( ( -LRB- cord-258172-p54j4zzo 170 3 testis testis NN cord-258172-p54j4zzo 170 4 ) ) -RRB- cord-258172-p54j4zzo 170 5 . . . cord-258172-p54j4zzo 171 1 Those those DT cord-258172-p54j4zzo 171 2 TFBSs tfbs NNS cord-258172-p54j4zzo 171 3 with with IN cord-258172-p54j4zzo 171 4 TFs tf NNS cord-258172-p54j4zzo 171 5 which which WDT cord-258172-p54j4zzo 171 6 strongly strongly RB cord-258172-p54j4zzo 171 7 ( ( -LRB- cord-258172-p54j4zzo 171 8 < < XX cord-258172-p54j4zzo 171 9 -0.7 -0.7 FW cord-258172-p54j4zzo 171 10 ) ) -RRB- cord-258172-p54j4zzo 171 11 negatively negatively RB cord-258172-p54j4zzo 171 12 correlate correlate VBP cord-258172-p54j4zzo 171 13 with with IN cord-258172-p54j4zzo 171 14 ACE2 ACE2 NNP cord-258172-p54j4zzo 171 15 are be VBP cord-258172-p54j4zzo 171 16 ESRRA ESRRA NNP cord-258172-p54j4zzo 171 17 ( ( -LRB- cord-258172-p54j4zzo 171 18 kidney kidney NN cord-258172-p54j4zzo 171 19 ) ) -RRB- cord-258172-p54j4zzo 171 20 and and CC cord-258172-p54j4zzo 171 21 TCFL72 TCFL72 NNP cord-258172-p54j4zzo 171 22 ( ( -LRB- cord-258172-p54j4zzo 171 23 kidney kidney NN cord-258172-p54j4zzo 171 24 ) ) -RRB- cord-258172-p54j4zzo 171 25 . . . cord-258172-p54j4zzo 172 1 The the DT cord-258172-p54j4zzo 172 2 lung lung NN cord-258172-p54j4zzo 172 3 - - HYPH cord-258172-p54j4zzo 172 4 specific specific JJ cord-258172-p54j4zzo 172 5 transcript transcript NN cord-258172-p54j4zzo 172 6 TSS TSS NNP cord-258172-p54j4zzo 172 7 aligns align VBZ cord-258172-p54j4zzo 172 8 with with IN cord-258172-p54j4zzo 172 9 the the DT cord-258172-p54j4zzo 172 10 p3@ACE2 p3@ACE2 NNP cord-258172-p54j4zzo 172 11 FANTOM5 FANTOM5 NNP cord-258172-p54j4zzo 172 12 dataset dataset NN cord-258172-p54j4zzo 172 13 CAGE CAGE NNP cord-258172-p54j4zzo 172 14 peak peak NN cord-258172-p54j4zzo 172 15 , , , cord-258172-p54j4zzo 172 16 which which WDT cord-258172-p54j4zzo 172 17 indicates indicate VBZ cord-258172-p54j4zzo 172 18 that that IN cord-258172-p54j4zzo 172 19 the the DT cord-258172-p54j4zzo 172 20 expression expression NN cord-258172-p54j4zzo 172 21 of of IN cord-258172-p54j4zzo 172 22 this this DT cord-258172-p54j4zzo 172 23 transcript transcript NN cord-258172-p54j4zzo 172 24 is be VBZ cord-258172-p54j4zzo 172 25 much much RB cord-258172-p54j4zzo 172 26 lower low JJR cord-258172-p54j4zzo 172 27 than than IN cord-258172-p54j4zzo 172 28 the the DT cord-258172-p54j4zzo 172 29 intestinal intestinal JJ cord-258172-p54j4zzo 172 30 transcript transcript NN cord-258172-p54j4zzo 172 31 , , , cord-258172-p54j4zzo 172 32 which which WDT cord-258172-p54j4zzo 172 33 corresponds correspond VBZ cord-258172-p54j4zzo 172 34 with with IN cord-258172-p54j4zzo 172 35 p1@ACE2 p1@ACE2 NNP cord-258172-p54j4zzo 172 36 and and CC cord-258172-p54j4zzo 172 37 p2@ACE2 p2@ACE2 NNP cord-258172-p54j4zzo 172 38 FANTOM5 fantom5 NN cord-258172-p54j4zzo 172 39 CAGE cage NN cord-258172-p54j4zzo 172 40 peaks peak NNS cord-258172-p54j4zzo 172 41 . . . cord-258172-p54j4zzo 173 1 Common common JJ cord-258172-p54j4zzo 173 2 between between IN cord-258172-p54j4zzo 173 3 the the DT cord-258172-p54j4zzo 173 4 two two CD cord-258172-p54j4zzo 173 5 tissue tissue NN cord-258172-p54j4zzo 173 6 - - HYPH cord-258172-p54j4zzo 173 7 specific specific JJ cord-258172-p54j4zzo 173 8 transcripts transcript NNS cord-258172-p54j4zzo 173 9 , , , cord-258172-p54j4zzo 173 10 are be VBP cord-258172-p54j4zzo 173 11 predictions prediction NNS cord-258172-p54j4zzo 173 12 for for IN cord-258172-p54j4zzo 173 13 CDX2 CDX2 NNP cord-258172-p54j4zzo 173 14 and and CC cord-258172-p54j4zzo 173 15 HNF HNF NNP cord-258172-p54j4zzo 173 16 - - HYPH cord-258172-p54j4zzo 173 17 family family NN cord-258172-p54j4zzo 173 18 transcription transcription NN cord-258172-p54j4zzo 173 19 factors factor NNS cord-258172-p54j4zzo 173 20 . . . cord-258172-p54j4zzo 174 1 An an DT cord-258172-p54j4zzo 174 2 expanded expand VBN cord-258172-p54j4zzo 174 3 analysis analysis NN cord-258172-p54j4zzo 174 4 for for IN cord-258172-p54j4zzo 174 5 binding bind VBG cord-258172-p54j4zzo 174 6 sites site NNS cord-258172-p54j4zzo 174 7 of of IN cord-258172-p54j4zzo 174 8 interferon interferon NN cord-258172-p54j4zzo 174 9 - - HYPH cord-258172-p54j4zzo 174 10 stimulation stimulation NN cord-258172-p54j4zzo 174 11 mediating mediate VBG cord-258172-p54j4zzo 174 12 TF TF NNP cord-258172-p54j4zzo 174 13 genes gene NNS cord-258172-p54j4zzo 174 14 in in IN cord-258172-p54j4zzo 174 15 the the DT cord-258172-p54j4zzo 174 16 region region NN cord-258172-p54j4zzo 174 17 1,500 1,500 CD cord-258172-p54j4zzo 174 18 bp bp NNP cord-258172-p54j4zzo 174 19 upstream upstream RB cord-258172-p54j4zzo 174 20 to to IN cord-258172-p54j4zzo 174 21 500 500 CD cord-258172-p54j4zzo 174 22 bp bp NNP cord-258172-p54j4zzo 174 23 downstream downstream NN cord-258172-p54j4zzo 174 24 of of IN cord-258172-p54j4zzo 174 25 the the DT cord-258172-p54j4zzo 174 26 lung lung NN cord-258172-p54j4zzo 174 27 transcript transcript NN cord-258172-p54j4zzo 174 28 's 's POS cord-258172-p54j4zzo 174 29 TSS TSS NNP cord-258172-p54j4zzo 174 30 revealed reveal VBD cord-258172-p54j4zzo 174 31 putative putative JJ cord-258172-p54j4zzo 174 32 binding bind VBG cord-258172-p54j4zzo 174 33 sites site NNS cord-258172-p54j4zzo 174 34 for for IN cord-258172-p54j4zzo 174 35 STAT1 stat1 NN cord-258172-p54j4zzo 174 36 : : : cord-258172-p54j4zzo 175 1 STAT2 STAT2 NNS cord-258172-p54j4zzo 175 2 dimer dimer NNP cord-258172-p54j4zzo 175 3 , , , cord-258172-p54j4zzo 175 4 STAT1 STAT1 NNP cord-258172-p54j4zzo 175 5 ( ( -LRB- cord-258172-p54j4zzo 175 6 2x 2x CD cord-258172-p54j4zzo 175 7 ) ) -RRB- cord-258172-p54j4zzo 175 8 , , , cord-258172-p54j4zzo 175 9 STAT3 STAT3 NNP cord-258172-p54j4zzo 175 10 , , , cord-258172-p54j4zzo 175 11 STAT4 stat4 NN cord-258172-p54j4zzo 175 12 , , , cord-258172-p54j4zzo 175 13 STAT6 stat6 NN cord-258172-p54j4zzo 175 14 ( ( -LRB- cord-258172-p54j4zzo 175 15 2x 2x CD cord-258172-p54j4zzo 175 16 ) ) -RRB- cord-258172-p54j4zzo 175 17 , , , cord-258172-p54j4zzo 175 18 and and CC cord-258172-p54j4zzo 175 19 IRF8 IRF8 NNP cord-258172-p54j4zzo 175 20 ( ( -LRB- cord-258172-p54j4zzo 175 21 S1 S1 NNP cord-258172-p54j4zzo 175 22 Fig Fig NNP cord-258172-p54j4zzo 175 23 ) ) -RRB- cord-258172-p54j4zzo 175 24 . . . cord-258172-p54j4zzo 176 1 Each each DT cord-258172-p54j4zzo 176 2 of of IN cord-258172-p54j4zzo 176 3 these these DT cord-258172-p54j4zzo 176 4 predictions prediction NNS cord-258172-p54j4zzo 176 5 satisfied satisfy VBD cord-258172-p54j4zzo 176 6 a a DT cord-258172-p54j4zzo 176 7 PWM PWM NNP cord-258172-p54j4zzo 176 8 p p NN cord-258172-p54j4zzo 176 9 - - HYPH cord-258172-p54j4zzo 176 10 value value NN cord-258172-p54j4zzo 176 11 threshold threshold NN cord-258172-p54j4zzo 176 12 of of IN cord-258172-p54j4zzo 176 13 < < NNP cord-258172-p54j4zzo 176 14 0.0001 0.0001 CD cord-258172-p54j4zzo 176 15 , , , cord-258172-p54j4zzo 176 16 while while IN cord-258172-p54j4zzo 176 17 only only RB cord-258172-p54j4zzo 176 18 the the DT cord-258172-p54j4zzo 176 19 IRF8 IRF8 NNP cord-258172-p54j4zzo 176 20 site site NN cord-258172-p54j4zzo 176 21 also also RB cord-258172-p54j4zzo 176 22 satisfied satisfy VBD cord-258172-p54j4zzo 176 23 a a DT cord-258172-p54j4zzo 176 24 combined combine VBN cord-258172-p54j4zzo 176 25 affinity affinity NN cord-258172-p54j4zzo 176 26 score score NN cord-258172-p54j4zzo 176 27 p p NN cord-258172-p54j4zzo 176 28 - - HYPH cord-258172-p54j4zzo 176 29 value value NN cord-258172-p54j4zzo 176 30 of of IN cord-258172-p54j4zzo 176 31 < < NNP cord-258172-p54j4zzo 176 32 0.05 0.05 CD cord-258172-p54j4zzo 176 33 . . . cord-258172-p54j4zzo 177 1 TFBS tfbs NN cord-258172-p54j4zzo 177 2 analysis analysis NN cord-258172-p54j4zzo 177 3 of of IN cord-258172-p54j4zzo 177 4 the the DT cord-258172-p54j4zzo 177 5 recently recently RB cord-258172-p54j4zzo 177 6 identified identify VBN cord-258172-p54j4zzo 177 7 putative putative JJ cord-258172-p54j4zzo 177 8 short short JJ cord-258172-p54j4zzo 177 9 form form NN cord-258172-p54j4zzo 177 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 177 11 transcript transcript NN cord-258172-p54j4zzo 177 12 [ [ -LRB- cord-258172-p54j4zzo 177 13 56 56 CD cord-258172-p54j4zzo 177 14 ] ] -RRB- cord-258172-p54j4zzo 178 1 [ [ -LRB- cord-258172-p54j4zzo 178 2 57 57 CD cord-258172-p54j4zzo 178 3 ] ] -RRB- cord-258172-p54j4zzo 178 4 [ [ -LRB- cord-258172-p54j4zzo 178 5 58 58 CD cord-258172-p54j4zzo 178 6 ] ] -RRB- cord-258172-p54j4zzo 178 7 , , , cord-258172-p54j4zzo 178 8 with with IN cord-258172-p54j4zzo 178 9 a a DT cord-258172-p54j4zzo 178 10 TSS tss NN cord-258172-p54j4zzo 178 11 between between IN cord-258172-p54j4zzo 178 12 exons exon NNS cord-258172-p54j4zzo 178 13 9 9 CD cord-258172-p54j4zzo 178 14 and and CC cord-258172-p54j4zzo 178 15 10 10 CD cord-258172-p54j4zzo 178 16 of of IN cord-258172-p54j4zzo 178 17 the the DT cord-258172-p54j4zzo 178 18 canonical canonical JJ cord-258172-p54j4zzo 178 19 gene gene NN cord-258172-p54j4zzo 178 20 , , , cord-258172-p54j4zzo 178 21 produced produce VBD cord-258172-p54j4zzo 178 22 predictions prediction NNS cord-258172-p54j4zzo 178 23 for for IN cord-258172-p54j4zzo 178 24 IRF9 IRF9 NNP cord-258172-p54j4zzo 178 25 , , , cord-258172-p54j4zzo 178 26 IRF8 IRF8 NNP cord-258172-p54j4zzo 178 27 , , , cord-258172-p54j4zzo 178 28 JUND JUND NNP cord-258172-p54j4zzo 178 29 , , , cord-258172-p54j4zzo 178 30 FOSL1 FOSL1 NNP cord-258172-p54j4zzo 178 31 , , , cord-258172-p54j4zzo 178 32 GATA1 gata1 XX cord-258172-p54j4zzo 178 33 , , , cord-258172-p54j4zzo 178 34 JUNB JUNB NNP cord-258172-p54j4zzo 178 35 , , , cord-258172-p54j4zzo 178 36 IRF4 IRF4 NNP cord-258172-p54j4zzo 178 37 , , , cord-258172-p54j4zzo 178 38 JUN JUN NNP cord-258172-p54j4zzo 178 39 , , , cord-258172-p54j4zzo 178 40 and and CC cord-258172-p54j4zzo 178 41 FOS FOS NNP cord-258172-p54j4zzo 178 42 , , , cord-258172-p54j4zzo 178 43 among among IN cord-258172-p54j4zzo 178 44 others other NNS cord-258172-p54j4zzo 178 45 ( ( -LRB- cord-258172-p54j4zzo 178 46 S5 S5 NNP cord-258172-p54j4zzo 178 47 Table Table NNP cord-258172-p54j4zzo 178 48 ) ) -RRB- cord-258172-p54j4zzo 178 49 . . . cord-258172-p54j4zzo 179 1 Within within IN cord-258172-p54j4zzo 179 2 the the DT cord-258172-p54j4zzo 179 3 first first JJ cord-258172-p54j4zzo 179 4 -56 -56 NN cord-258172-p54j4zzo 179 5 to to IN cord-258172-p54j4zzo 179 6 -31 -31 CD cord-258172-p54j4zzo 179 7 bp bp NNP cord-258172-p54j4zzo 179 8 upstream upstream RB cord-258172-p54j4zzo 179 9 of of IN cord-258172-p54j4zzo 179 10 the the DT cord-258172-p54j4zzo 179 11 short short JJ cord-258172-p54j4zzo 179 12 - - HYPH cord-258172-p54j4zzo 179 13 form form NN cord-258172-p54j4zzo 179 14 ACE2 ACE2 NNP cord-258172-p54j4zzo 179 15 TSS TSS NNP cord-258172-p54j4zzo 179 16 , , , cord-258172-p54j4zzo 179 17 are be VBP cord-258172-p54j4zzo 179 18 overlapping overlap VBG cord-258172-p54j4zzo 179 19 binding bind VBG cord-258172-p54j4zzo 179 20 sites site NNS cord-258172-p54j4zzo 179 21 for for IN cord-258172-p54j4zzo 179 22 several several JJ cord-258172-p54j4zzo 179 23 IRF IRF NNP cord-258172-p54j4zzo 179 24 TFs TFs NNPS cord-258172-p54j4zzo 179 25 and and CC cord-258172-p54j4zzo 179 26 a a DT cord-258172-p54j4zzo 179 27 STAT1 stat1 NN cord-258172-p54j4zzo 179 28 : : : cord-258172-p54j4zzo 179 29 STAT2 STAT2 NNS cord-258172-p54j4zzo 179 30 dimer dimer NN cord-258172-p54j4zzo 179 31 , , , cord-258172-p54j4zzo 179 32 while while IN cord-258172-p54j4zzo 179 33 further further JJ cord-258172-p54j4zzo 179 34 upstream upstream RB cord-258172-p54j4zzo 179 35 are be VBP cord-258172-p54j4zzo 179 36 binding bind VBG cord-258172-p54j4zzo 179 37 sites site NNS cord-258172-p54j4zzo 179 38 for for IN cord-258172-p54j4zzo 179 39 several several JJ cord-258172-p54j4zzo 179 40 STAT stat NN cord-258172-p54j4zzo 179 41 TFs tf NNS cord-258172-p54j4zzo 179 42 at at IN cord-258172-p54j4zzo 179 43 -662 -662 NN cord-258172-p54j4zzo 179 44 to to IN cord-258172-p54j4zzo 179 45 -647 -647 VBN cord-258172-p54j4zzo 179 46 bp bp NNP cord-258172-p54j4zzo 180 1 and and CC cord-258172-p54j4zzo 180 2 -911 -911 NNP cord-258172-p54j4zzo 180 3 to to TO cord-258172-p54j4zzo 180 4 -897 -897 VB cord-258172-p54j4zzo 181 1 ( ( -LRB- cord-258172-p54j4zzo 181 2 Fig Fig NNP cord-258172-p54j4zzo 181 3 9 9 CD cord-258172-p54j4zzo 181 4 ) ) -RRB- cord-258172-p54j4zzo 181 5 . . . cord-258172-p54j4zzo 182 1 Each each DT cord-258172-p54j4zzo 182 2 of of IN cord-258172-p54j4zzo 182 3 these these DT cord-258172-p54j4zzo 182 4 predictions prediction NNS cord-258172-p54j4zzo 182 5 satisfied satisfy VBD cord-258172-p54j4zzo 182 6 a a DT cord-258172-p54j4zzo 182 7 PWM PWM NNP cord-258172-p54j4zzo 182 8 p p NN cord-258172-p54j4zzo 182 9 - - HYPH cord-258172-p54j4zzo 182 10 value value NN cord-258172-p54j4zzo 182 11 threshold threshold NN cord-258172-p54j4zzo 182 12 of of IN cord-258172-p54j4zzo 182 13 < < NNP cord-258172-p54j4zzo 182 14 0.001 0.001 CD cord-258172-p54j4zzo 182 15 , , , cord-258172-p54j4zzo 182 16 while while IN cord-258172-p54j4zzo 182 17 only only RB cord-258172-p54j4zzo 182 18 the the DT cord-258172-p54j4zzo 182 19 IRF9 IRF9 NNP cord-258172-p54j4zzo 182 20 , , , cord-258172-p54j4zzo 182 21 IRF8 IRF8 NNP cord-258172-p54j4zzo 182 22 , , , cord-258172-p54j4zzo 182 23 and and CC cord-258172-p54j4zzo 182 24 IRF4 IRF4 NNP cord-258172-p54j4zzo 182 25 sites site NNS cord-258172-p54j4zzo 182 26 also also RB cord-258172-p54j4zzo 182 27 satisfied satisfy VBD cord-258172-p54j4zzo 182 28 a a DT cord-258172-p54j4zzo 182 29 combined combine VBN cord-258172-p54j4zzo 182 30 affinity affinity NN cord-258172-p54j4zzo 182 31 score score NN cord-258172-p54j4zzo 182 32 p p NN cord-258172-p54j4zzo 182 33 - - HYPH cord-258172-p54j4zzo 182 34 value value NN cord-258172-p54j4zzo 182 35 of of IN cord-258172-p54j4zzo 182 36 < < NNP cord-258172-p54j4zzo 182 37 0.05 0.05 CD cord-258172-p54j4zzo 182 38 . . . cord-258172-p54j4zzo 183 1 Coexpression Coexpression NNP cord-258172-p54j4zzo 183 2 analysis analysis NN cord-258172-p54j4zzo 183 3 identified identify VBD cord-258172-p54j4zzo 183 4 numerous numerous JJ cord-258172-p54j4zzo 183 5 genes gene NNS cord-258172-p54j4zzo 183 6 in in IN cord-258172-p54j4zzo 183 7 ileum ileum NN cord-258172-p54j4zzo 183 8 , , , cord-258172-p54j4zzo 183 9 testis testis NN cord-258172-p54j4zzo 183 10 , , , cord-258172-p54j4zzo 183 11 colon colon NN cord-258172-p54j4zzo 183 12 , , , cord-258172-p54j4zzo 183 13 and and CC cord-258172-p54j4zzo 183 14 kidney kidney NN cord-258172-p54j4zzo 183 15 which which WDT cord-258172-p54j4zzo 183 16 are be VBP cord-258172-p54j4zzo 183 17 highly highly RB cord-258172-p54j4zzo 183 18 correlated correlate VBN cord-258172-p54j4zzo 183 19 ( ( -LRB- cord-258172-p54j4zzo 183 20 > > VBZ cord-258172-p54j4zzo 183 21 0.8 0.8 CD cord-258172-p54j4zzo 183 22 ) ) -RRB- cord-258172-p54j4zzo 183 23 with with IN cord-258172-p54j4zzo 183 24 ACE2 ACE2 NNP cord-258172-p54j4zzo 183 25 ( ( -LRB- cord-258172-p54j4zzo 183 26 Tables table NNS cord-258172-p54j4zzo 183 27 1 1 CD cord-258172-p54j4zzo 183 28 and and CC cord-258172-p54j4zzo 183 29 S7 S7 NNP cord-258172-p54j4zzo 183 30 ) ) -RRB- cord-258172-p54j4zzo 183 31 . . . cord-258172-p54j4zzo 184 1 In in IN cord-258172-p54j4zzo 184 2 particular particular JJ cord-258172-p54j4zzo 184 3 , , , cord-258172-p54j4zzo 184 4 in in IN cord-258172-p54j4zzo 184 5 the the DT cord-258172-p54j4zzo 184 6 ileum ileum NN cord-258172-p54j4zzo 184 7 there there EX cord-258172-p54j4zzo 184 8 are be VBP cord-258172-p54j4zzo 184 9 a a DT cord-258172-p54j4zzo 184 10 number number NN cord-258172-p54j4zzo 184 11 of of IN cord-258172-p54j4zzo 184 12 genes gene NNS cord-258172-p54j4zzo 184 13 with with IN cord-258172-p54j4zzo 184 14 correlation correlation NN cord-258172-p54j4zzo 184 15 values value NNS cord-258172-p54j4zzo 184 16 greater great JJR cord-258172-p54j4zzo 184 17 than than IN cord-258172-p54j4zzo 184 18 0.95 0.95 CD cord-258172-p54j4zzo 184 19 . . . cord-258172-p54j4zzo 185 1 In in IN cord-258172-p54j4zzo 185 2 contrast contrast NN cord-258172-p54j4zzo 185 3 , , , cord-258172-p54j4zzo 185 4 analysis analysis NN cord-258172-p54j4zzo 185 5 of of IN cord-258172-p54j4zzo 185 6 the the DT cord-258172-p54j4zzo 185 7 lung lung NN cord-258172-p54j4zzo 185 8 shows show VBZ cord-258172-p54j4zzo 185 9 a a DT cord-258172-p54j4zzo 185 10 maximum maximum JJ cord-258172-p54j4zzo 185 11 correlation correlation NN cord-258172-p54j4zzo 185 12 of of IN cord-258172-p54j4zzo 185 13 expression expression NN cord-258172-p54j4zzo 185 14 of of IN cord-258172-p54j4zzo 185 15 0.6275 0.6275 CD cord-258172-p54j4zzo 185 16 . . . cord-258172-p54j4zzo 186 1 The the DT cord-258172-p54j4zzo 186 2 genes gene NNS cord-258172-p54j4zzo 186 3 with with IN cord-258172-p54j4zzo 186 4 which which WDT cord-258172-p54j4zzo 187 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 187 2 mRNA mrna NN cord-258172-p54j4zzo 188 1 expression expression NN cord-258172-p54j4zzo 188 2 shows show VBZ cord-258172-p54j4zzo 188 3 the the DT cord-258172-p54j4zzo 188 4 highest high JJS cord-258172-p54j4zzo 188 5 levels level NNS cord-258172-p54j4zzo 188 6 of of IN cord-258172-p54j4zzo 188 7 coexpression coexpression NNP cord-258172-p54j4zzo 188 8 code code NNP cord-258172-p54j4zzo 188 9 for for IN cord-258172-p54j4zzo 188 10 metalloprotease metalloprotease NNP cord-258172-p54j4zzo 188 11 and and CC cord-258172-p54j4zzo 188 12 transporter transporter NN cord-258172-p54j4zzo 188 13 proteins protein NNS cord-258172-p54j4zzo 188 14 . . . cord-258172-p54j4zzo 189 1 Selected select VBN cord-258172-p54j4zzo 189 2 tissue tissue NN cord-258172-p54j4zzo 189 3 - - HYPH cord-258172-p54j4zzo 189 4 specific specific JJ cord-258172-p54j4zzo 189 5 ACE2-correlated ace2-correlated JJ cord-258172-p54j4zzo 189 6 genes gene NNS cord-258172-p54j4zzo 189 7 , , , cord-258172-p54j4zzo 189 8 determined determine VBN cord-258172-p54j4zzo 189 9 with with IN cord-258172-p54j4zzo 189 10 bulk bulk JJ cord-258172-p54j4zzo 189 11 RNA RNA NNP cord-258172-p54j4zzo 189 12 - - HYPH cord-258172-p54j4zzo 189 13 Seq Seq NNP cord-258172-p54j4zzo 189 14 data datum NNS cord-258172-p54j4zzo 189 15 , , , cord-258172-p54j4zzo 189 16 are be VBP cord-258172-p54j4zzo 189 17 presented present VBN cord-258172-p54j4zzo 189 18 with with IN cord-258172-p54j4zzo 189 19 their -PRON- PRP$ cord-258172-p54j4zzo 189 20 expression expression NN cord-258172-p54j4zzo 189 21 levels level NNS cord-258172-p54j4zzo 189 22 within within IN cord-258172-p54j4zzo 189 23 the the DT cord-258172-p54j4zzo 189 24 scRNA scrna NN cord-258172-p54j4zzo 189 25 - - HYPH cord-258172-p54j4zzo 189 26 Seq seq NN cord-258172-p54j4zzo 189 27 trachea trachea NN cord-258172-p54j4zzo 189 28 and and CC cord-258172-p54j4zzo 189 29 intestinal intestinal JJ cord-258172-p54j4zzo 189 30 datasets dataset NNS cord-258172-p54j4zzo 189 31 in in IN cord-258172-p54j4zzo 189 32 _SP cord-258172-p54j4zzo 189 33 GO GO NNP cord-258172-p54j4zzo 189 34 enrichment enrichment NN cord-258172-p54j4zzo 189 35 analysis analysis NN cord-258172-p54j4zzo 189 36 of of IN cord-258172-p54j4zzo 189 37 ACE2 ACE2 NNP cord-258172-p54j4zzo 189 38 mRNA mRNA NNP cord-258172-p54j4zzo 189 39 expression expression NN cord-258172-p54j4zzo 189 40 in in IN cord-258172-p54j4zzo 189 41 all all DT cord-258172-p54j4zzo 189 42 tissues tissue NNS cord-258172-p54j4zzo 189 43 produced produce VBD cord-258172-p54j4zzo 189 44 22 22 CD cord-258172-p54j4zzo 189 45 terms term NNS cord-258172-p54j4zzo 189 46 which which WDT cord-258172-p54j4zzo 189 47 were be VBD cord-258172-p54j4zzo 189 48 enriched enrich VBN cord-258172-p54j4zzo 189 49 in in IN cord-258172-p54j4zzo 189 50 BP BP NNP cord-258172-p54j4zzo 189 51 , , , cord-258172-p54j4zzo 189 52 CC CC NNP cord-258172-p54j4zzo 189 53 , , , cord-258172-p54j4zzo 189 54 HP HP NNP cord-258172-p54j4zzo 189 55 , , , cord-258172-p54j4zzo 189 56 KEGG KEGG NNP cord-258172-p54j4zzo 189 57 , , , cord-258172-p54j4zzo 189 58 and and CC cord-258172-p54j4zzo 189 59 WP WP NNP cord-258172-p54j4zzo 189 60 ontologies ontology NNS cord-258172-p54j4zzo 189 61 ( ( -LRB- cord-258172-p54j4zzo 189 62 _SP cord-258172-p54j4zzo 189 63 The the DT cord-258172-p54j4zzo 189 64 predominant predominant JJ cord-258172-p54j4zzo 189 65 pathological pathological JJ cord-258172-p54j4zzo 189 66 features feature NNS cord-258172-p54j4zzo 189 67 of of IN cord-258172-p54j4zzo 189 68 COVID-19 covid-19 JJ cord-258172-p54j4zzo 189 69 infection infection NN cord-258172-p54j4zzo 189 70 largely largely RB cord-258172-p54j4zzo 189 71 mimic mimic VBP cord-258172-p54j4zzo 189 72 those those DT cord-258172-p54j4zzo 189 73 previously previously RB cord-258172-p54j4zzo 189 74 reported report VBN cord-258172-p54j4zzo 189 75 for for IN cord-258172-p54j4zzo 189 76 SARS SARS NNP cord-258172-p54j4zzo 189 77 - - HYPH cord-258172-p54j4zzo 189 78 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 189 79 infection infection NN cord-258172-p54j4zzo 189 80 . . . cord-258172-p54j4zzo 190 1 They -PRON- PRP cord-258172-p54j4zzo 190 2 include include VBP cord-258172-p54j4zzo 190 3 dry dry JJ cord-258172-p54j4zzo 190 4 cough cough NN cord-258172-p54j4zzo 190 5 , , , cord-258172-p54j4zzo 190 6 persistent persistent JJ cord-258172-p54j4zzo 190 7 fever fever NN cord-258172-p54j4zzo 190 8 , , , cord-258172-p54j4zzo 190 9 progressive progressive JJ cord-258172-p54j4zzo 190 10 dyspnea dyspnea NN cord-258172-p54j4zzo 190 11 , , , cord-258172-p54j4zzo 190 12 and and CC cord-258172-p54j4zzo 190 13 in in IN cord-258172-p54j4zzo 190 14 some some DT cord-258172-p54j4zzo 190 15 cases case NNS cord-258172-p54j4zzo 190 16 acute acute JJ cord-258172-p54j4zzo 190 17 exacerbation exacerbation NN cord-258172-p54j4zzo 190 18 of of IN cord-258172-p54j4zzo 190 19 lung lung NN cord-258172-p54j4zzo 190 20 function function NN cord-258172-p54j4zzo 190 21 with with IN cord-258172-p54j4zzo 190 22 bilateral bilateral JJ cord-258172-p54j4zzo 190 23 pneumonia pneumonia NN cord-258172-p54j4zzo 190 24 [ [ -LRB- cord-258172-p54j4zzo 190 25 32 32 CD cord-258172-p54j4zzo 190 26 ] ] -RRB- cord-258172-p54j4zzo 190 27 . . . cord-258172-p54j4zzo 191 1 Major major JJ cord-258172-p54j4zzo 191 2 lung lung NN cord-258172-p54j4zzo 191 3 lesions lesion NNS cord-258172-p54j4zzo 191 4 include include VBP cord-258172-p54j4zzo 191 5 several several JJ cord-258172-p54j4zzo 191 6 pathological pathological JJ cord-258172-p54j4zzo 191 7 signs sign NNS cord-258172-p54j4zzo 191 8 , , , cord-258172-p54j4zzo 191 9 such such JJ cord-258172-p54j4zzo 191 10 as as IN cord-258172-p54j4zzo 191 11 diffuse diffuse JJ cord-258172-p54j4zzo 191 12 alveolar alveolar JJ cord-258172-p54j4zzo 191 13 damage damage NN cord-258172-p54j4zzo 191 14 , , , cord-258172-p54j4zzo 191 15 inflammatory inflammatory JJ cord-258172-p54j4zzo 191 16 exudation exudation NN cord-258172-p54j4zzo 191 17 in in IN cord-258172-p54j4zzo 191 18 the the DT cord-258172-p54j4zzo 191 19 alveoli alveolus NNS cord-258172-p54j4zzo 191 20 and and CC cord-258172-p54j4zzo 191 21 interstitial interstitial JJ cord-258172-p54j4zzo 191 22 tissue tissue NN cord-258172-p54j4zzo 191 23 , , , cord-258172-p54j4zzo 191 24 hyperplasia hyperplasia NN cord-258172-p54j4zzo 191 25 of of IN cord-258172-p54j4zzo 191 26 fibrous fibrous JJ cord-258172-p54j4zzo 191 27 tissue tissue NN cord-258172-p54j4zzo 191 28 , , , cord-258172-p54j4zzo 191 29 and and CC cord-258172-p54j4zzo 191 30 eventually eventually RB cord-258172-p54j4zzo 191 31 lung lung NN cord-258172-p54j4zzo 191 32 fibrosis fibrosis NN cord-258172-p54j4zzo 191 33 [ [ -LRB- cord-258172-p54j4zzo 191 34 59 59 CD cord-258172-p54j4zzo 191 35 ] ] -RRB- cord-258172-p54j4zzo 192 1 [ [ -LRB- cord-258172-p54j4zzo 192 2 60 60 CD cord-258172-p54j4zzo 192 3 ] ] -RRB- cord-258172-p54j4zzo 192 4 [ [ -LRB- cord-258172-p54j4zzo 192 5 61 61 CD cord-258172-p54j4zzo 192 6 ] ] -RRB- cord-258172-p54j4zzo 192 7 . . . cord-258172-p54j4zzo 193 1 It -PRON- PRP cord-258172-p54j4zzo 193 2 has have VBZ cord-258172-p54j4zzo 193 3 been be VBN cord-258172-p54j4zzo 193 4 shown show VBN cord-258172-p54j4zzo 193 5 by by IN cord-258172-p54j4zzo 193 6 fluorescence fluorescence NN cord-258172-p54j4zzo 193 7 in in IN cord-258172-p54j4zzo 193 8 situ situ JJ cord-258172-p54j4zzo 193 9 hybridization hybridization NN cord-258172-p54j4zzo 193 10 technique technique NN cord-258172-p54j4zzo 193 11 that that WDT cord-258172-p54j4zzo 193 12 SARS SARS NNP cord-258172-p54j4zzo 193 13 - - HYPH cord-258172-p54j4zzo 193 14 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 193 15 RNA RNA NNP cord-258172-p54j4zzo 193 16 locates locate VBZ cord-258172-p54j4zzo 193 17 to to IN cord-258172-p54j4zzo 193 18 the the DT cord-258172-p54j4zzo 193 19 alveolar alveolar JJ cord-258172-p54j4zzo 193 20 pneumocytes pneumocyte NNS cord-258172-p54j4zzo 193 21 and and CC cord-258172-p54j4zzo 193 22 alveolar alveolar NN cord-258172-p54j4zzo 193 23 space space NN cord-258172-p54j4zzo 193 24 [ [ -LRB- cord-258172-p54j4zzo 193 25 62 62 CD cord-258172-p54j4zzo 193 26 , , , cord-258172-p54j4zzo 193 27 63 63 CD cord-258172-p54j4zzo 193 28 ] ] -RRB- cord-258172-p54j4zzo 193 29 . . . cord-258172-p54j4zzo 194 1 Mossel Mossel NNP cord-258172-p54j4zzo 194 2 and and CC cord-258172-p54j4zzo 194 3 colleagues colleague NNS cord-258172-p54j4zzo 194 4 demonstrated demonstrate VBD cord-258172-p54j4zzo 194 5 that that IN cord-258172-p54j4zzo 194 6 SARS SARS NNP cord-258172-p54j4zzo 194 7 - - HYPH cord-258172-p54j4zzo 194 8 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 194 9 replicates replicate VBZ cord-258172-p54j4zzo 194 10 in in IN cord-258172-p54j4zzo 194 11 type type NN cord-258172-p54j4zzo 194 12 2 2 CD cord-258172-p54j4zzo 194 13 ( ( -LRB- cord-258172-p54j4zzo 194 14 AT2 at2 NN cord-258172-p54j4zzo 194 15 ) ) -RRB- cord-258172-p54j4zzo 194 16 pneumocytes pneumocyte NNS cord-258172-p54j4zzo 194 17 , , , cord-258172-p54j4zzo 194 18 but but CC cord-258172-p54j4zzo 194 19 [ [ -LRB- cord-258172-p54j4zzo 194 20 36 36 CD cord-258172-p54j4zzo 194 21 ] ] -RRB- cord-258172-p54j4zzo 194 22 and and CC cord-258172-p54j4zzo 194 23 has have VBZ cord-258172-p54j4zzo 194 24 been be VBN cord-258172-p54j4zzo 194 25 identified identify VBN cord-258172-p54j4zzo 194 26 as as IN cord-258172-p54j4zzo 194 27 potentially potentially RB cord-258172-p54j4zzo 194 28 relevant relevant JJ cord-258172-p54j4zzo 194 29 for for IN cord-258172-p54j4zzo 194 30 interferon interferon NN cord-258172-p54j4zzo 194 31 - - HYPH cord-258172-p54j4zzo 194 32 mediated mediate VBN cord-258172-p54j4zzo 194 33 transcription transcription NN cord-258172-p54j4zzo 194 34 of of IN cord-258172-p54j4zzo 194 35 this this DT cord-258172-p54j4zzo 194 36 new new JJ cord-258172-p54j4zzo 194 37 ACE2 ACE2 NNP cord-258172-p54j4zzo 194 38 transcript transcript NN cord-258172-p54j4zzo 194 39 [ [ -LRB- cord-258172-p54j4zzo 194 40 56 56 CD cord-258172-p54j4zzo 194 41 ] ] -RRB- cord-258172-p54j4zzo 194 42 ; ; : cord-258172-p54j4zzo 194 43 it -PRON- PRP cord-258172-p54j4zzo 194 44 is be VBZ cord-258172-p54j4zzo 194 45 displayed display VBN cord-258172-p54j4zzo 194 46 in in IN cord-258172-p54j4zzo 194 47 the the DT cord-258172-p54j4zzo 194 48 CAGE CAGE NNP cord-258172-p54j4zzo 194 49 peaks peak NNS cord-258172-p54j4zzo 194 50 track track NN cord-258172-p54j4zzo 194 51 along along IN cord-258172-p54j4zzo 194 52 with with IN cord-258172-p54j4zzo 194 53 an an DT cord-258172-p54j4zzo 194 54 arrow arrow NN cord-258172-p54j4zzo 194 55 indicating indicate VBG cord-258172-p54j4zzo 194 56 the the DT cord-258172-p54j4zzo 194 57 TSS TSS NNP cord-258172-p54j4zzo 194 58 . . . cord-258172-p54j4zzo 195 1 The the DT cord-258172-p54j4zzo 195 2 region region NN cord-258172-p54j4zzo 195 3 analyzed analyze VBD cord-258172-p54j4zzo 195 4 represents represent VBZ cord-258172-p54j4zzo 195 5 -1,000 -1,000 NNP cord-258172-p54j4zzo 195 6 bp bp NNP cord-258172-p54j4zzo 195 7 to to IN cord-258172-p54j4zzo 195 8 +200 +200 NNP cord-258172-p54j4zzo 195 9 bp bp NNP cord-258172-p54j4zzo 195 10 relative relative NN cord-258172-p54j4zzo 195 11 to to IN cord-258172-p54j4zzo 195 12 the the DT cord-258172-p54j4zzo 195 13 putative putative JJ cord-258172-p54j4zzo 195 14 TSS tss NN cord-258172-p54j4zzo 195 15 , , , cord-258172-p54j4zzo 195 16 while while IN cord-258172-p54j4zzo 195 17 nucleotide nucleotide JJ cord-258172-p54j4zzo 195 18 positions position NNS cord-258172-p54j4zzo 195 19 at at IN cord-258172-p54j4zzo 195 20 bottom bottom NN cord-258172-p54j4zzo 195 21 are be VBP cord-258172-p54j4zzo 195 22 given give VBN cord-258172-p54j4zzo 195 23 relative relative JJ cord-258172-p54j4zzo 195 24 to to IN cord-258172-p54j4zzo 195 25 the the DT cord-258172-p54j4zzo 195 26 ACE2 ACE2 NNP cord-258172-p54j4zzo 195 27 full full JJ cord-258172-p54j4zzo 195 28 length length NN cord-258172-p54j4zzo 195 29 transcript transcript NN cord-258172-p54j4zzo 195 30 . . . cord-258172-p54j4zzo 196 1 https://doi.org/10.1371/journal.pone.0240647.g009 https://doi.org/10.1371/journal.pone.0240647.g009 NN cord-258172-p54j4zzo 197 1 Table table NN cord-258172-p54j4zzo 197 2 1 1 CD cord-258172-p54j4zzo 197 3 . . . cord-258172-p54j4zzo 198 1 Genes gene NNS cord-258172-p54j4zzo 198 2 associated associate VBN cord-258172-p54j4zzo 198 3 with with IN cord-258172-p54j4zzo 198 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 198 5 mRNA mRNA NNP cord-258172-p54j4zzo 198 6 expression expression NN cord-258172-p54j4zzo 198 7 in in IN cord-258172-p54j4zzo 198 8 selected select VBN cord-258172-p54j4zzo 198 9 human human JJ cord-258172-p54j4zzo 198 10 tissues tissue NNS cord-258172-p54j4zzo 198 11 . . . cord-258172-p54j4zzo 199 1 Derived derive VBN cord-258172-p54j4zzo 199 2 from from IN cord-258172-p54j4zzo 199 3 GTEx GTEx NNP cord-258172-p54j4zzo 199 4 bulk bulk JJ cord-258172-p54j4zzo 199 5 RNA RNA NNP cord-258172-p54j4zzo 199 6 - - HYPH cord-258172-p54j4zzo 199 7 Seq Seq NNP cord-258172-p54j4zzo 199 8 data datum NNS cord-258172-p54j4zzo 199 9 [ [ -LRB- cord-258172-p54j4zzo 199 10 39 39 CD cord-258172-p54j4zzo 199 11 ] ] -RRB- cord-258172-p54j4zzo 199 12 . . . cord-258172-p54j4zzo 200 1 not not RB cord-258172-p54j4zzo 200 2 in in IN cord-258172-p54j4zzo 200 3 type type NN cord-258172-p54j4zzo 200 4 1 1 CD cord-258172-p54j4zzo 200 5 ( ( -LRB- cord-258172-p54j4zzo 200 6 AT1 at1 NN cord-258172-p54j4zzo 200 7 ) ) -RRB- cord-258172-p54j4zzo 200 8 cells cell NNS cord-258172-p54j4zzo 200 9 [ [ -LRB- cord-258172-p54j4zzo 200 10 64 64 CD cord-258172-p54j4zzo 200 11 ] ] -RRB- cord-258172-p54j4zzo 200 12 . . . cord-258172-p54j4zzo 201 1 Considering consider VBG cord-258172-p54j4zzo 201 2 all all DT cord-258172-p54j4zzo 201 3 of of IN cord-258172-p54j4zzo 201 4 these these DT cord-258172-p54j4zzo 201 5 facts fact NNS cord-258172-p54j4zzo 201 6 , , , cord-258172-p54j4zzo 201 7 it -PRON- PRP cord-258172-p54j4zzo 201 8 is be VBZ cord-258172-p54j4zzo 201 9 not not RB cord-258172-p54j4zzo 201 10 surprising surprising JJ cord-258172-p54j4zzo 201 11 that that IN cord-258172-p54j4zzo 201 12 most most RBS cord-258172-p54j4zzo 201 13 histopathological histopathological JJ cord-258172-p54j4zzo 201 14 analyses analysis NNS cord-258172-p54j4zzo 201 15 have have VBP cord-258172-p54j4zzo 201 16 been be VBN cord-258172-p54j4zzo 201 17 focused focus VBN cord-258172-p54j4zzo 201 18 on on IN cord-258172-p54j4zzo 201 19 distal distal JJ cord-258172-p54j4zzo 201 20 parts part NNS cord-258172-p54j4zzo 201 21 of of IN cord-258172-p54j4zzo 201 22 the the DT cord-258172-p54j4zzo 201 23 respiratory respiratory JJ cord-258172-p54j4zzo 201 24 airways airway NNS cord-258172-p54j4zzo 201 25 , , , cord-258172-p54j4zzo 201 26 while while IN cord-258172-p54j4zzo 201 27 the the DT cord-258172-p54j4zzo 201 28 regions region NNS cord-258172-p54j4zzo 201 29 other other JJ cord-258172-p54j4zzo 201 30 than than IN cord-258172-p54j4zzo 201 31 the the DT cord-258172-p54j4zzo 201 32 alveolus alveolus NNP cord-258172-p54j4zzo 201 33 have have VBP cord-258172-p54j4zzo 201 34 been be VBN cord-258172-p54j4zzo 201 35 less less RBR cord-258172-p54j4zzo 201 36 systematically systematically RB cord-258172-p54j4zzo 201 37 studied study VBN cord-258172-p54j4zzo 201 38 . . . cord-258172-p54j4zzo 202 1 To to TO cord-258172-p54j4zzo 202 2 understand understand VB cord-258172-p54j4zzo 202 3 better well JJR cord-258172-p54j4zzo 202 4 the the DT cord-258172-p54j4zzo 202 5 pathogenesis pathogenesis NN cord-258172-p54j4zzo 202 6 of of IN cord-258172-p54j4zzo 202 7 COVID-19 covid-19 NN cord-258172-p54j4zzo 202 8 we -PRON- PRP cord-258172-p54j4zzo 202 9 need need VBP cord-258172-p54j4zzo 202 10 to to TO cord-258172-p54j4zzo 202 11 know know VB cord-258172-p54j4zzo 202 12 where where WRB cord-258172-p54j4zzo 202 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 202 14 , , , cord-258172-p54j4zzo 202 15 the the DT cord-258172-p54j4zzo 202 16 receptor receptor NN cord-258172-p54j4zzo 202 17 for for IN cord-258172-p54j4zzo 202 18 SARS SARS NNP cord-258172-p54j4zzo 202 19 - - HYPH cord-258172-p54j4zzo 202 20 CoV CoV NNP cord-258172-p54j4zzo 202 21 , , , cord-258172-p54j4zzo 202 22 is be VBZ cord-258172-p54j4zzo 202 23 located locate VBN cord-258172-p54j4zzo 202 24 within within IN cord-258172-p54j4zzo 202 25 the the DT cord-258172-p54j4zzo 202 26 human human JJ cord-258172-p54j4zzo 202 27 respiratory respiratory JJ cord-258172-p54j4zzo 202 28 tract tract NN cord-258172-p54j4zzo 202 29 and and CC cord-258172-p54j4zzo 202 30 elsewhere elsewhere RB cord-258172-p54j4zzo 202 31 . . . cord-258172-p54j4zzo 203 1 Overall overall RB cord-258172-p54j4zzo 203 2 , , , cord-258172-p54j4zzo 203 3 different different JJ cord-258172-p54j4zzo 203 4 studies study NNS cord-258172-p54j4zzo 203 5 including include VBG cord-258172-p54j4zzo 203 6 ours our NNS cord-258172-p54j4zzo 203 7 have have VBP cord-258172-p54j4zzo 203 8 convincingly convincingly RB cord-258172-p54j4zzo 203 9 shown show VBN cord-258172-p54j4zzo 203 10 that that IN cord-258172-p54j4zzo 203 11 several several JJ cord-258172-p54j4zzo 203 12 organs organ NNS cord-258172-p54j4zzo 203 13 , , , cord-258172-p54j4zzo 203 14 such such JJ cord-258172-p54j4zzo 203 15 as as IN cord-258172-p54j4zzo 203 16 the the DT cord-258172-p54j4zzo 203 17 small small JJ cord-258172-p54j4zzo 203 18 intestine intestine NN cord-258172-p54j4zzo 203 19 , , , cord-258172-p54j4zzo 203 20 colon colon NN cord-258172-p54j4zzo 203 21 , , , cord-258172-p54j4zzo 203 22 kidney kidney NN cord-258172-p54j4zzo 203 23 , , , cord-258172-p54j4zzo 203 24 and and CC cord-258172-p54j4zzo 203 25 testis testis NN cord-258172-p54j4zzo 203 26 , , , cord-258172-p54j4zzo 203 27 express express VBP cord-258172-p54j4zzo 203 28 higher high JJR cord-258172-p54j4zzo 203 29 levels level NNS cord-258172-p54j4zzo 203 30 of of IN cord-258172-p54j4zzo 203 31 ACE2 ACE2 NNP cord-258172-p54j4zzo 203 32 than than IN cord-258172-p54j4zzo 203 33 the the DT cord-258172-p54j4zzo 203 34 lung lung NN cord-258172-p54j4zzo 203 35 and and CC cord-258172-p54j4zzo 203 36 other other JJ cord-258172-p54j4zzo 203 37 parts part NNS cord-258172-p54j4zzo 203 38 of of IN cord-258172-p54j4zzo 203 39 the the DT cord-258172-p54j4zzo 203 40 respiratory respiratory JJ cord-258172-p54j4zzo 203 41 tract tract NN cord-258172-p54j4zzo 203 42 . . . cord-258172-p54j4zzo 204 1 Our -PRON- PRP$ cord-258172-p54j4zzo 204 2 analysis analysis NN cord-258172-p54j4zzo 204 3 of of IN cord-258172-p54j4zzo 204 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 204 5 expression expression NN cord-258172-p54j4zzo 204 6 in in IN cord-258172-p54j4zzo 204 7 the the DT cord-258172-p54j4zzo 204 8 human human JJ cord-258172-p54j4zzo 204 9 lung lung NN cord-258172-p54j4zzo 204 10 show show NN cord-258172-p54j4zzo 204 11 low low JJ cord-258172-p54j4zzo 204 12 levels level NNS cord-258172-p54j4zzo 204 13 of of IN cord-258172-p54j4zzo 204 14 expression expression NN cord-258172-p54j4zzo 204 15 in in IN cord-258172-p54j4zzo 204 16 all all DT cord-258172-p54j4zzo 204 17 cell cell NN cord-258172-p54j4zzo 204 18 types type NNS cord-258172-p54j4zzo 204 19 , , , cord-258172-p54j4zzo 204 20 with with IN cord-258172-p54j4zzo 204 21 arterial arterial JJ cord-258172-p54j4zzo 204 22 vascular vascular JJ cord-258172-p54j4zzo 204 23 endothelial endothelial JJ cord-258172-p54j4zzo 204 24 cells cell NNS cord-258172-p54j4zzo 204 25 achieving achieve VBG cord-258172-p54j4zzo 204 26 the the DT cord-258172-p54j4zzo 204 27 highest high JJS cord-258172-p54j4zzo 204 28 overall overall JJ cord-258172-p54j4zzo 204 29 ratio ratio NN cord-258172-p54j4zzo 204 30 of of IN cord-258172-p54j4zzo 204 31 just~2.5 just~2.5 NNP cord-258172-p54j4zzo 204 32 % % NN cord-258172-p54j4zzo 204 33 . . . cord-258172-p54j4zzo 205 1 The the DT cord-258172-p54j4zzo 205 2 present present JJ cord-258172-p54j4zzo 205 3 results result NNS cord-258172-p54j4zzo 205 4 based base VBN cord-258172-p54j4zzo 205 5 on on IN cord-258172-p54j4zzo 205 6 mouse mouse NN cord-258172-p54j4zzo 205 7 tracheal tracheal NN cord-258172-p54j4zzo 205 8 dataset dataset NN cord-258172-p54j4zzo 205 9 suggested suggest VBD cord-258172-p54j4zzo 205 10 that that IN cord-258172-p54j4zzo 205 11 ACE2 ACE2 NNP cord-258172-p54j4zzo 205 12 mRNA mrna NN cord-258172-p54j4zzo 205 13 is be VBZ cord-258172-p54j4zzo 205 14 predominantly predominantly RB cord-258172-p54j4zzo 205 15 expressed express VBN cord-258172-p54j4zzo 205 16 in in IN cord-258172-p54j4zzo 205 17 the the DT cord-258172-p54j4zzo 205 18 club club NN cord-258172-p54j4zzo 205 19 cells cell NNS cord-258172-p54j4zzo 205 20 , , , cord-258172-p54j4zzo 205 21 goblet goblet NN cord-258172-p54j4zzo 205 22 cells cell NNS cord-258172-p54j4zzo 205 23 , , , cord-258172-p54j4zzo 205 24 and and CC cord-258172-p54j4zzo 205 25 ciliated ciliated JJ cord-258172-p54j4zzo 205 26 epithelial epithelial JJ cord-258172-p54j4zzo 205 27 cells cell NNS cord-258172-p54j4zzo 205 28 , , , cord-258172-p54j4zzo 205 29 and and CC cord-258172-p54j4zzo 205 30 at at IN cord-258172-p54j4zzo 205 31 significantly significantly RB cord-258172-p54j4zzo 205 32 higher high JJR cord-258172-p54j4zzo 205 33 frequency frequency NN cord-258172-p54j4zzo 205 34 than than IN cord-258172-p54j4zzo 205 35 found find VBN cord-258172-p54j4zzo 205 36 in in IN cord-258172-p54j4zzo 205 37 the the DT cord-258172-p54j4zzo 205 38 lung lung NN cord-258172-p54j4zzo 205 39 . . . cord-258172-p54j4zzo 206 1 The the DT cord-258172-p54j4zzo 206 2 mouse mouse NN cord-258172-p54j4zzo 206 3 dataset dataset NN cord-258172-p54j4zzo 206 4 used use VBN cord-258172-p54j4zzo 206 5 in in IN cord-258172-p54j4zzo 206 6 our -PRON- PRP$ cord-258172-p54j4zzo 206 7 study study NN cord-258172-p54j4zzo 206 8 contained contain VBD cord-258172-p54j4zzo 206 9 no no DT cord-258172-p54j4zzo 206 10 secretory3 secretory3 NN cord-258172-p54j4zzo 206 11 cells cell NNS cord-258172-p54j4zzo 206 12 , , , cord-258172-p54j4zzo 206 13 which which WDT cord-258172-p54j4zzo 206 14 Lukassen Lukassen NNP cord-258172-p54j4zzo 206 15 and and CC cord-258172-p54j4zzo 206 16 colleagues colleague NNS cord-258172-p54j4zzo 206 17 recently recently RB cord-258172-p54j4zzo 206 18 reported report VBD cord-258172-p54j4zzo 206 19 to to IN cord-258172-p54j4zzo 206 20 Trachea trachea NN cord-258172-p54j4zzo 206 21 expression expression NN cord-258172-p54j4zzo 206 22 data datum NNS cord-258172-p54j4zzo 206 23 is be VBZ cord-258172-p54j4zzo 206 24 taken take VBN cord-258172-p54j4zzo 206 25 from from IN cord-258172-p54j4zzo 206 26 GSE103354 GSE103354 NNP cord-258172-p54j4zzo 206 27 [ [ -LRB- cord-258172-p54j4zzo 206 28 51 51 CD cord-258172-p54j4zzo 206 29 ] ] -RRB- cord-258172-p54j4zzo 206 30 and and CC cord-258172-p54j4zzo 206 31 intestinal intestinal JJ cord-258172-p54j4zzo 206 32 epithelia epithelium NNS cord-258172-p54j4zzo 206 33 data datum NNS cord-258172-p54j4zzo 206 34 is be VBZ cord-258172-p54j4zzo 206 35 derived derive VBN cord-258172-p54j4zzo 206 36 from from IN cord-258172-p54j4zzo 206 37 GSE92332 GSE92332 NNP cord-258172-p54j4zzo 206 38 [ [ -LRB- cord-258172-p54j4zzo 206 39 52 52 CD cord-258172-p54j4zzo 206 40 ] ] -RRB- cord-258172-p54j4zzo 206 41 . . . cord-258172-p54j4zzo 207 1 Visualized visualize VBN cord-258172-p54j4zzo 207 2 in in IN cord-258172-p54j4zzo 207 3 ScanPy scanpy CD cord-258172-p54j4zzo 207 4 [ [ -LRB- cord-258172-p54j4zzo 207 5 54 54 CD cord-258172-p54j4zzo 207 6 ] ] -RRB- cord-258172-p54j4zzo 207 7 . . . cord-258172-p54j4zzo 208 1 https://doi.org/10.1371/journal.pone.0240647.g010 https://doi.org/10.1371/journal.pone.0240647.g010 NNP cord-258172-p54j4zzo 208 2 express express VB cord-258172-p54j4zzo 208 3 the the DT cord-258172-p54j4zzo 208 4 highest high JJS cord-258172-p54j4zzo 208 5 levels level NNS cord-258172-p54j4zzo 208 6 of of IN cord-258172-p54j4zzo 209 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 209 2 mRNA mrna NN cord-258172-p54j4zzo 210 1 along along IN cord-258172-p54j4zzo 210 2 the the DT cord-258172-p54j4zzo 210 3 human human JJ cord-258172-p54j4zzo 210 4 respiratory respiratory JJ cord-258172-p54j4zzo 210 5 tract tract NN cord-258172-p54j4zzo 210 6 [ [ -LRB- cord-258172-p54j4zzo 210 7 65 65 CD cord-258172-p54j4zzo 210 8 ] ] -RRB- cord-258172-p54j4zzo 210 9 . . . cord-258172-p54j4zzo 211 1 Another another DT cord-258172-p54j4zzo 211 2 study study NN cord-258172-p54j4zzo 211 3 reported report VBD cord-258172-p54j4zzo 211 4 positive positive JJ cord-258172-p54j4zzo 211 5 expression expression NN cord-258172-p54j4zzo 211 6 in in IN cord-258172-p54j4zzo 211 7 the the DT cord-258172-p54j4zzo 211 8 type type NN cord-258172-p54j4zzo 211 9 AT2 at2 NN cord-258172-p54j4zzo 211 10 pneumocytes pneumocyte NNS cord-258172-p54j4zzo 211 11 [ [ -LRB- cord-258172-p54j4zzo 211 12 66 66 CD cord-258172-p54j4zzo 211 13 ] ] -RRB- cord-258172-p54j4zzo 211 14 , , , cord-258172-p54j4zzo 211 15 which which WDT cord-258172-p54j4zzo 211 16 is be VBZ cord-258172-p54j4zzo 211 17 in in IN cord-258172-p54j4zzo 211 18 line line NN cord-258172-p54j4zzo 211 19 with with IN cord-258172-p54j4zzo 211 20 the the DT cord-258172-p54j4zzo 211 21 results result NNS cord-258172-p54j4zzo 211 22 of of IN cord-258172-p54j4zzo 211 23 Lukassen Lukassen NNP cord-258172-p54j4zzo 211 24 et et NNP cord-258172-p54j4zzo 211 25 al al NNP cord-258172-p54j4zzo 211 26 . . . cord-258172-p54j4zzo 212 1 [ [ -LRB- cord-258172-p54j4zzo 212 2 65 65 CD cord-258172-p54j4zzo 212 3 ] ] -RRB- cord-258172-p54j4zzo 212 4 , , , cord-258172-p54j4zzo 212 5 but but CC cord-258172-p54j4zzo 212 6 only only RB cord-258172-p54j4zzo 212 7 a a DT cord-258172-p54j4zzo 212 8 few few JJ cord-258172-p54j4zzo 212 9 cells cell NNS cord-258172-p54j4zzo 212 10 appeared appear VBD cord-258172-p54j4zzo 212 11 positive positive JJ cord-258172-p54j4zzo 212 12 . . . cord-258172-p54j4zzo 213 1 A a DT cord-258172-p54j4zzo 213 2 third third JJ cord-258172-p54j4zzo 213 3 study study NN cord-258172-p54j4zzo 213 4 based base VBN cord-258172-p54j4zzo 213 5 on on IN cord-258172-p54j4zzo 213 6 single single JJ cord-258172-p54j4zzo 213 7 cell cell NN cord-258172-p54j4zzo 213 8 expression expression NN cord-258172-p54j4zzo 213 9 data datum NNS cord-258172-p54j4zzo 213 10 demonstrated demonstrate VBD cord-258172-p54j4zzo 213 11 the the DT cord-258172-p54j4zzo 213 12 strongest strong JJS cord-258172-p54j4zzo 213 13 positive positive JJ cord-258172-p54j4zzo 213 14 signal signal NN cord-258172-p54j4zzo 213 15 in in IN cord-258172-p54j4zzo 213 16 the the DT cord-258172-p54j4zzo 213 17 lung lung NN cord-258172-p54j4zzo 213 18 AT2 at2 NN cord-258172-p54j4zzo 213 19 cells cell NNS cord-258172-p54j4zzo 213 20 , , , cord-258172-p54j4zzo 213 21 while while IN cord-258172-p54j4zzo 213 22 other other JJ cord-258172-p54j4zzo 213 23 cells cell NNS cord-258172-p54j4zzo 213 24 including include VBG cord-258172-p54j4zzo 213 25 AT1 at1 NN cord-258172-p54j4zzo 213 26 cells cell NNS cord-258172-p54j4zzo 213 27 , , , cord-258172-p54j4zzo 213 28 club club NN cord-258172-p54j4zzo 213 29 cells cell NNS cord-258172-p54j4zzo 213 30 , , , cord-258172-p54j4zzo 213 31 ciliated ciliated JJ cord-258172-p54j4zzo 213 32 cells cell NNS cord-258172-p54j4zzo 213 33 , , , cord-258172-p54j4zzo 213 34 and and CC cord-258172-p54j4zzo 213 35 macrophages macrophage NNS cord-258172-p54j4zzo 213 36 showed show VBD cord-258172-p54j4zzo 213 37 weaker weak JJR cord-258172-p54j4zzo 213 38 expression expression NN cord-258172-p54j4zzo 213 39 [ [ -LRB- cord-258172-p54j4zzo 213 40 67 67 CD cord-258172-p54j4zzo 213 41 ] ] -RRB- cord-258172-p54j4zzo 213 42 . . . cord-258172-p54j4zzo 214 1 A a DT cord-258172-p54j4zzo 214 2 fourth fourth JJ cord-258172-p54j4zzo 214 3 single single JJ cord-258172-p54j4zzo 214 4 cell cell NN cord-258172-p54j4zzo 214 5 expression expression NN cord-258172-p54j4zzo 214 6 analysis analysis NN cord-258172-p54j4zzo 214 7 using use VBG cord-258172-p54j4zzo 214 8 Gene Gene NNP cord-258172-p54j4zzo 214 9 Expression Expression NNP cord-258172-p54j4zzo 214 10 Omnibus Omnibus NNP cord-258172-p54j4zzo 214 11 ( ( -LRB- cord-258172-p54j4zzo 214 12 GEO GEO NNP cord-258172-p54j4zzo 214 13 ) ) -RRB- cord-258172-p54j4zzo 214 14 database database NN cord-258172-p54j4zzo 214 15 recently recently RB cord-258172-p54j4zzo 214 16 demonstrated demonstrate VBD cord-258172-p54j4zzo 214 17 ACE2-positive ace2-positive JJ cord-258172-p54j4zzo 214 18 signal signal NN cord-258172-p54j4zzo 214 19 in in IN cord-258172-p54j4zzo 214 20 1 1 CD cord-258172-p54j4zzo 214 21 % % NN cord-258172-p54j4zzo 214 22 of of IN cord-258172-p54j4zzo 214 23 AT2 at2 NN cord-258172-p54j4zzo 214 24 cells cell NNS cord-258172-p54j4zzo 214 25 and and CC cord-258172-p54j4zzo 214 26 in in IN cord-258172-p54j4zzo 214 27 2 2 CD cord-258172-p54j4zzo 214 28 % % NN cord-258172-p54j4zzo 214 29 of of IN cord-258172-p54j4zzo 214 30 respiratory respiratory JJ cord-258172-p54j4zzo 214 31 tract tract NN cord-258172-p54j4zzo 214 32 epithelial epithelial JJ cord-258172-p54j4zzo 214 33 cells cell NNS cord-258172-p54j4zzo 214 34 [ [ -LRB- cord-258172-p54j4zzo 214 35 68 68 CD cord-258172-p54j4zzo 214 36 ] ] -RRB- cord-258172-p54j4zzo 214 37 . . . cord-258172-p54j4zzo 215 1 This this DT cord-258172-p54j4zzo 215 2 correlates correlate VBZ cord-258172-p54j4zzo 215 3 with with IN cord-258172-p54j4zzo 215 4 our -PRON- PRP$ cord-258172-p54j4zzo 215 5 own own JJ cord-258172-p54j4zzo 215 6 findings finding NNS cord-258172-p54j4zzo 215 7 for for IN cord-258172-p54j4zzo 215 8 lung lung NN cord-258172-p54j4zzo 215 9 . . . cord-258172-p54j4zzo 216 1 For for IN cord-258172-p54j4zzo 216 2 comparison comparison NN cord-258172-p54j4zzo 216 3 about about RB cord-258172-p54j4zzo 216 4 30 30 CD cord-258172-p54j4zzo 216 5 % % NN cord-258172-p54j4zzo 216 6 of of IN cord-258172-p54j4zzo 216 7 ileal ileal JJ cord-258172-p54j4zzo 216 8 epithelial epithelial JJ cord-258172-p54j4zzo 216 9 cells cell NNS cord-258172-p54j4zzo 216 10 were be VBD cord-258172-p54j4zzo 216 11 ACE2-positive ace2-positive JJ cord-258172-p54j4zzo 216 12 , , , cord-258172-p54j4zzo 216 13 and and CC cord-258172-p54j4zzo 216 14 44 44 CD cord-258172-p54j4zzo 216 15 % % NN cord-258172-p54j4zzo 216 16 of of IN cord-258172-p54j4zzo 216 17 enterocytes enterocyte NNS cord-258172-p54j4zzo 216 18 in in IN cord-258172-p54j4zzo 216 19 small small JJ cord-258172-p54j4zzo 216 20 intestine intestine NN cord-258172-p54j4zzo 216 21 of of IN cord-258172-p54j4zzo 216 22 mouse mouse NN cord-258172-p54j4zzo 216 23 . . . cord-258172-p54j4zzo 217 1 Immunohistochemical immunohistochemical JJ cord-258172-p54j4zzo 217 2 analysis analysis NN cord-258172-p54j4zzo 217 3 of of IN cord-258172-p54j4zzo 217 4 mouse mouse NN cord-258172-p54j4zzo 217 5 tissues tissue NNS cord-258172-p54j4zzo 217 6 has have VBZ cord-258172-p54j4zzo 217 7 shown show VBN cord-258172-p54j4zzo 217 8 positive positive JJ cord-258172-p54j4zzo 217 9 signal signal NN cord-258172-p54j4zzo 217 10 in in IN cord-258172-p54j4zzo 217 11 the the DT cord-258172-p54j4zzo 217 12 club club NN cord-258172-p54j4zzo 217 13 cells cell NNS cord-258172-p54j4zzo 217 14 , , , cord-258172-p54j4zzo 217 15 AT2 at2 NN cord-258172-p54j4zzo 217 16 cells cell NNS cord-258172-p54j4zzo 217 17 , , , cord-258172-p54j4zzo 217 18 endothelial endothelial JJ cord-258172-p54j4zzo 217 19 cells cell NNS cord-258172-p54j4zzo 217 20 , , , cord-258172-p54j4zzo 217 21 and and CC cord-258172-p54j4zzo 217 22 smooth smooth JJ cord-258172-p54j4zzo 217 23 muscle muscle NN cord-258172-p54j4zzo 217 24 cells cell NNS cord-258172-p54j4zzo 217 25 [ [ -LRB- cord-258172-p54j4zzo 217 26 69 69 CD cord-258172-p54j4zzo 217 27 ] ] -RRB- cord-258172-p54j4zzo 217 28 . . . cord-258172-p54j4zzo 218 1 In in IN cord-258172-p54j4zzo 218 2 spite spite NN cord-258172-p54j4zzo 218 3 of of IN cord-258172-p54j4zzo 218 4 the the DT cord-258172-p54j4zzo 218 5 obvious obvious JJ cord-258172-p54j4zzo 218 6 discrepancies discrepancy NNS cord-258172-p54j4zzo 218 7 between between IN cord-258172-p54j4zzo 218 8 different different JJ cord-258172-p54j4zzo 218 9 datasets dataset NNS cord-258172-p54j4zzo 218 10 , , , cord-258172-p54j4zzo 218 11 that that WDT cord-258172-p54j4zzo 218 12 highlights highlight VBZ cord-258172-p54j4zzo 218 13 the the DT cord-258172-p54j4zzo 218 14 need need NN cord-258172-p54j4zzo 218 15 for for IN cord-258172-p54j4zzo 218 16 large large JJ cord-258172-p54j4zzo 218 17 numbers number NNS cord-258172-p54j4zzo 218 18 of of IN cord-258172-p54j4zzo 218 19 thoroughly thoroughly RB cord-258172-p54j4zzo 218 20 characterized characterize VBN cord-258172-p54j4zzo 218 21 cells cell NNS cord-258172-p54j4zzo 218 22 for for IN cord-258172-p54j4zzo 218 23 single single JJ cord-258172-p54j4zzo 218 24 cell cell NN cord-258172-p54j4zzo 218 25 RNA rna NN cord-258172-p54j4zzo 218 26 - - HYPH cord-258172-p54j4zzo 218 27 Seq seq NN cord-258172-p54j4zzo 218 28 analyses analysis NNS cord-258172-p54j4zzo 218 29 , , , cord-258172-p54j4zzo 218 30 we -PRON- PRP cord-258172-p54j4zzo 218 31 can can MD cord-258172-p54j4zzo 218 32 now now RB cord-258172-p54j4zzo 218 33 make make VB cord-258172-p54j4zzo 218 34 some some DT cord-258172-p54j4zzo 218 35 conclusions conclusion NNS cord-258172-p54j4zzo 218 36 of of IN cord-258172-p54j4zzo 218 37 the the DT cord-258172-p54j4zzo 218 38 expression expression NN cord-258172-p54j4zzo 218 39 of of IN cord-258172-p54j4zzo 218 40 ACE2 ACE2 NNP cord-258172-p54j4zzo 218 41 mRNA mrna NN cord-258172-p54j4zzo 218 42 in in IN cord-258172-p54j4zzo 218 43 the the DT cord-258172-p54j4zzo 218 44 respiratory respiratory JJ cord-258172-p54j4zzo 218 45 tract tract NN cord-258172-p54j4zzo 218 46 . . . cord-258172-p54j4zzo 219 1 First first RB cord-258172-p54j4zzo 219 2 , , , cord-258172-p54j4zzo 219 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 219 4 is be VBZ cord-258172-p54j4zzo 219 5 positively positively RB cord-258172-p54j4zzo 219 6 though though RB cord-258172-p54j4zzo 219 7 weakly weakly RB cord-258172-p54j4zzo 219 8 expressed express VBN cord-258172-p54j4zzo 219 9 in in IN cord-258172-p54j4zzo 219 10 the the DT cord-258172-p54j4zzo 219 11 AT2 at2 NN cord-258172-p54j4zzo 219 12 cells cell NNS cord-258172-p54j4zzo 219 13 of of IN cord-258172-p54j4zzo 219 14 the the DT cord-258172-p54j4zzo 219 15 lung lung NN cord-258172-p54j4zzo 219 16 and and CC cord-258172-p54j4zzo 219 17 less less RBR cord-258172-p54j4zzo 219 18 so so RB cord-258172-p54j4zzo 219 19 in in IN cord-258172-p54j4zzo 219 20 AT1 at1 NN cord-258172-p54j4zzo 219 21 cells cell NNS cord-258172-p54j4zzo 219 22 . . . cord-258172-p54j4zzo 220 1 Second second RB cord-258172-p54j4zzo 220 2 , , , cord-258172-p54j4zzo 220 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 220 4 also also RB cord-258172-p54j4zzo 220 5 shows show VBZ cord-258172-p54j4zzo 220 6 a a DT cord-258172-p54j4zzo 220 7 weak weak JJ cord-258172-p54j4zzo 220 8 positive positive JJ cord-258172-p54j4zzo 220 9 signal signal NN cord-258172-p54j4zzo 220 10 , , , cord-258172-p54j4zzo 220 11 but but CC cord-258172-p54j4zzo 220 12 at at IN cord-258172-p54j4zzo 220 13 significantly significantly RB cord-258172-p54j4zzo 220 14 higher high JJR cord-258172-p54j4zzo 220 15 proportions proportion NNS cord-258172-p54j4zzo 220 16 of of IN cord-258172-p54j4zzo 220 17 cells cell NNS cord-258172-p54j4zzo 220 18 , , , cord-258172-p54j4zzo 220 19 in in IN cord-258172-p54j4zzo 220 20 several several JJ cord-258172-p54j4zzo 220 21 other other JJ cord-258172-p54j4zzo 220 22 cell cell NN cord-258172-p54j4zzo 220 23 types type NNS cord-258172-p54j4zzo 220 24 of of IN cord-258172-p54j4zzo 220 25 the the DT cord-258172-p54j4zzo 220 26 trachea trachea NN cord-258172-p54j4zzo 220 27 , , , cord-258172-p54j4zzo 220 28 including include VBG cord-258172-p54j4zzo 220 29 goblet goblet NN cord-258172-p54j4zzo 220 30 cells cell NNS cord-258172-p54j4zzo 220 31 , , , cord-258172-p54j4zzo 220 32 club club NN cord-258172-p54j4zzo 220 33 cells cell NNS cord-258172-p54j4zzo 220 34 , , , cord-258172-p54j4zzo 220 35 and and CC cord-258172-p54j4zzo 220 36 ciliated ciliated JJ cord-258172-p54j4zzo 220 37 cells cell NNS cord-258172-p54j4zzo 220 38 . . . cord-258172-p54j4zzo 221 1 Third third RB cord-258172-p54j4zzo 221 2 , , , cord-258172-p54j4zzo 221 3 based base VBN cord-258172-p54j4zzo 221 4 on on IN cord-258172-p54j4zzo 221 5 the the DT cord-258172-p54j4zzo 221 6 findings finding NNS cord-258172-p54j4zzo 221 7 of of IN cord-258172-p54j4zzo 221 8 Lukassen Lukassen NNP cord-258172-p54j4zzo 221 9 et et NNP cord-258172-p54j4zzo 221 10 al al NNP cord-258172-p54j4zzo 221 11 . . . cord-258172-p54j4zzo 222 1 [ [ -LRB- cord-258172-p54j4zzo 222 2 65 65 CD cord-258172-p54j4zzo 222 3 ] ] -RRB- cord-258172-p54j4zzo 222 4 secretory3 secretory3 NN cord-258172-p54j4zzo 222 5 cells cell NNS cord-258172-p54j4zzo 222 6 , , , cord-258172-p54j4zzo 222 7 a a DT cord-258172-p54j4zzo 222 8 transient transient JJ cord-258172-p54j4zzo 222 9 cell cell NN cord-258172-p54j4zzo 222 10 type type NN cord-258172-p54j4zzo 222 11 of of IN cord-258172-p54j4zzo 222 12 the the DT cord-258172-p54j4zzo 222 13 bronchial bronchial JJ cord-258172-p54j4zzo 222 14 tree tree NN cord-258172-p54j4zzo 222 15 , , , cord-258172-p54j4zzo 222 16 may may MD cord-258172-p54j4zzo 222 17 express express VB cord-258172-p54j4zzo 222 18 the the DT cord-258172-p54j4zzo 222 19 highest high JJS cord-258172-p54j4zzo 222 20 levels level NNS cord-258172-p54j4zzo 222 21 of of IN cord-258172-p54j4zzo 222 22 ACE2 ACE2 NNP cord-258172-p54j4zzo 222 23 . . . cord-258172-p54j4zzo 223 1 These these DT cord-258172-p54j4zzo 223 2 ACE2-positive ace2-positive JJ cord-258172-p54j4zzo 223 3 cell cell NN cord-258172-p54j4zzo 223 4 types type NNS cord-258172-p54j4zzo 223 5 may may MD cord-258172-p54j4zzo 223 6 represent represent VB cord-258172-p54j4zzo 223 7 the the DT cord-258172-p54j4zzo 223 8 main main JJ cord-258172-p54j4zzo 223 9 host host NN cord-258172-p54j4zzo 223 10 cells cell NNS cord-258172-p54j4zzo 223 11 for for IN cord-258172-p54j4zzo 223 12 SARS SARS NNP cord-258172-p54j4zzo 223 13 - - HYPH cord-258172-p54j4zzo 223 14 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 223 15 along along IN cord-258172-p54j4zzo 223 16 the the DT cord-258172-p54j4zzo 223 17 whole whole JJ cord-258172-p54j4zzo 223 18 respiratory respiratory JJ cord-258172-p54j4zzo 223 19 tract tract NN cord-258172-p54j4zzo 223 20 . . . cord-258172-p54j4zzo 224 1 However however RB cord-258172-p54j4zzo 224 2 , , , cord-258172-p54j4zzo 224 3 the the DT cord-258172-p54j4zzo 224 4 median median JJ cord-258172-p54j4zzo 224 5 percentage percentage NN cord-258172-p54j4zzo 224 6 of of IN cord-258172-p54j4zzo 224 7 ACE ace NN cord-258172-p54j4zzo 224 8 - - HYPH cord-258172-p54j4zzo 224 9 expressing express VBG cord-258172-p54j4zzo 224 10 secretory3 secretory3 NN cord-258172-p54j4zzo 224 11 cells cell NNS cord-258172-p54j4zzo 224 12 in in IN cord-258172-p54j4zzo 224 13 the the DT cord-258172-p54j4zzo 224 14 study study NN cord-258172-p54j4zzo 224 15 was be VBD cord-258172-p54j4zzo 224 16 less less JJR cord-258172-p54j4zzo 224 17 than than IN cord-258172-p54j4zzo 224 18 6 6 CD cord-258172-p54j4zzo 224 19 % % NN cord-258172-p54j4zzo 224 20 , , , cord-258172-p54j4zzo 224 21 significantly significantly RB cord-258172-p54j4zzo 224 22 less less JJR cord-258172-p54j4zzo 224 23 than than IN cord-258172-p54j4zzo 224 24 that that DT cord-258172-p54j4zzo 224 25 observed observe VBN cord-258172-p54j4zzo 224 26 in in IN cord-258172-p54j4zzo 224 27 club club NN cord-258172-p54j4zzo 224 28 ( ( -LRB- cord-258172-p54j4zzo 224 29 16.62 16.62 CD cord-258172-p54j4zzo 224 30 % % NN cord-258172-p54j4zzo 224 31 ) ) -RRB- cord-258172-p54j4zzo 224 32 , , , cord-258172-p54j4zzo 224 33 goblet goblet NN cord-258172-p54j4zzo 224 34 ( ( -LRB- cord-258172-p54j4zzo 224 35 13.84 13.84 CD cord-258172-p54j4zzo 224 36 % % NN cord-258172-p54j4zzo 224 37 ) ) -RRB- cord-258172-p54j4zzo 224 38 , , , cord-258172-p54j4zzo 224 39 and and CC cord-258172-p54j4zzo 224 40 ciliated ciliated JJ cord-258172-p54j4zzo 224 41 ( ( -LRB- cord-258172-p54j4zzo 224 42 6.63 6.63 CD cord-258172-p54j4zzo 224 43 % % NN cord-258172-p54j4zzo 224 44 ) ) -RRB- cord-258172-p54j4zzo 224 45 cells cell NNS cord-258172-p54j4zzo 224 46 of of IN cord-258172-p54j4zzo 224 47 trachea trachea NN cord-258172-p54j4zzo 224 48 we -PRON- PRP cord-258172-p54j4zzo 224 49 have have VBP cord-258172-p54j4zzo 224 50 identified identify VBN cord-258172-p54j4zzo 224 51 in in IN cord-258172-p54j4zzo 224 52 the the DT cord-258172-p54j4zzo 224 53 GSE103354 GSE103354 NNP cord-258172-p54j4zzo 224 54 dataset dataset NN cord-258172-p54j4zzo 224 55 . . . cord-258172-p54j4zzo 225 1 Goblet goblet NN cord-258172-p54j4zzo 225 2 cells cell NNS cord-258172-p54j4zzo 225 3 , , , cord-258172-p54j4zzo 225 4 ciliated ciliated JJ cord-258172-p54j4zzo 225 5 epithelial epithelial JJ cord-258172-p54j4zzo 225 6 cells cell NNS cord-258172-p54j4zzo 225 7 , , , cord-258172-p54j4zzo 225 8 and and CC cord-258172-p54j4zzo 225 9 club club NN cord-258172-p54j4zzo 225 10 cells cell NNS cord-258172-p54j4zzo 225 11 are be VBP cord-258172-p54j4zzo 225 12 considered consider VBN cord-258172-p54j4zzo 225 13 important important JJ cord-258172-p54j4zzo 225 14 cell cell NN cord-258172-p54j4zzo 225 15 types type NNS cord-258172-p54j4zzo 225 16 for for IN cord-258172-p54j4zzo 225 17 the the DT cord-258172-p54j4zzo 225 18 protection protection NN cord-258172-p54j4zzo 225 19 of of IN cord-258172-p54j4zzo 225 20 airway airway NN cord-258172-p54j4zzo 225 21 mucosa mucosa NN cord-258172-p54j4zzo 225 22 . . . cord-258172-p54j4zzo 226 1 Lukassen Lukassen NNP cord-258172-p54j4zzo 226 2 and and CC cord-258172-p54j4zzo 226 3 coworkers coworker NNS cord-258172-p54j4zzo 226 4 [ [ -LRB- cord-258172-p54j4zzo 226 5 65 65 CD cord-258172-p54j4zzo 226 6 ] ] -RRB- cord-258172-p54j4zzo 226 7 described describe VBN cord-258172-p54j4zzo 226 8 secretory3 secretory3 NN cord-258172-p54j4zzo 226 9 cells cell NNS cord-258172-p54j4zzo 226 10 as as IN cord-258172-p54j4zzo 226 11 intermediate intermediate JJ cord-258172-p54j4zzo 226 12 cells cell NNS cord-258172-p54j4zzo 226 13 between between IN cord-258172-p54j4zzo 226 14 goblet goblet NN cord-258172-p54j4zzo 226 15 , , , cord-258172-p54j4zzo 226 16 ciliated ciliated JJ cord-258172-p54j4zzo 226 17 , , , cord-258172-p54j4zzo 226 18 and and CC cord-258172-p54j4zzo 226 19 club club NN cord-258172-p54j4zzo 226 20 cells cell NNS cord-258172-p54j4zzo 226 21 . . . cord-258172-p54j4zzo 227 1 If if IN cord-258172-p54j4zzo 227 2 SARS SARS NNP cord-258172-p54j4zzo 227 3 - - HYPH cord-258172-p54j4zzo 227 4 coronaviruses coronaviruses NNP cord-258172-p54j4zzo 227 5 predominantly predominantly RB cord-258172-p54j4zzo 227 6 attack attack VBP cord-258172-p54j4zzo 227 7 these these DT cord-258172-p54j4zzo 227 8 cells cell NNS cord-258172-p54j4zzo 227 9 , , , cord-258172-p54j4zzo 227 10 locating locate VBG cord-258172-p54j4zzo 227 11 along along IN cord-258172-p54j4zzo 227 12 the the DT cord-258172-p54j4zzo 227 13 airway airway NN cord-258172-p54j4zzo 227 14 segments segment NNS cord-258172-p54j4zzo 227 15 including include VBG cord-258172-p54j4zzo 227 16 the the DT cord-258172-p54j4zzo 227 17 trachea trachea NN cord-258172-p54j4zzo 227 18 , , , cord-258172-p54j4zzo 227 19 bronchi bronchi NN cord-258172-p54j4zzo 227 20 , , , cord-258172-p54j4zzo 227 21 and and CC cord-258172-p54j4zzo 227 22 bronchioles bronchiole NNS cord-258172-p54j4zzo 227 23 until until IN cord-258172-p54j4zzo 227 24 the the DT cord-258172-p54j4zzo 227 25 last last JJ cord-258172-p54j4zzo 227 26 segment segment NN cord-258172-p54j4zzo 227 27 that that WDT cord-258172-p54j4zzo 227 28 is be VBZ cord-258172-p54j4zzo 227 29 the the DT cord-258172-p54j4zzo 227 30 respiratory respiratory JJ cord-258172-p54j4zzo 227 31 bronchioles bronchiole NNS cord-258172-p54j4zzo 227 32 , , , cord-258172-p54j4zzo 227 33 it -PRON- PRP cord-258172-p54j4zzo 227 34 would would MD cord-258172-p54j4zzo 227 35 be be VB cord-258172-p54j4zzo 227 36 obvious obvious JJ cord-258172-p54j4zzo 227 37 that that IN cord-258172-p54j4zzo 227 38 physiological physiological JJ cord-258172-p54j4zzo 227 39 protective protective JJ cord-258172-p54j4zzo 227 40 mechanisms mechanism NNS cord-258172-p54j4zzo 227 41 are be VBP cord-258172-p54j4zzo 227 42 severely severely RB cord-258172-p54j4zzo 227 43 affected affect VBN cord-258172-p54j4zzo 227 44 . . . cord-258172-p54j4zzo 228 1 Defective defective JJ cord-258172-p54j4zzo 228 2 mucosal mucosal JJ cord-258172-p54j4zzo 228 3 protection protection NN cord-258172-p54j4zzo 228 4 and and CC cord-258172-p54j4zzo 228 5 inefficient inefficient JJ cord-258172-p54j4zzo 228 6 removal removal NN cord-258172-p54j4zzo 228 7 of of IN cord-258172-p54j4zzo 228 8 pathogens pathogen NNS cord-258172-p54j4zzo 228 9 due due JJ cord-258172-p54j4zzo 228 10 to to IN cord-258172-p54j4zzo 228 11 viral viral JJ cord-258172-p54j4zzo 228 12 infection infection NN cord-258172-p54j4zzo 228 13 may may MD cord-258172-p54j4zzo 228 14 contribute contribute VB cord-258172-p54j4zzo 228 15 to to IN cord-258172-p54j4zzo 228 16 onset onset NN cord-258172-p54j4zzo 228 17 of of IN cord-258172-p54j4zzo 228 18 severe severe JJ cord-258172-p54j4zzo 228 19 bilateral bilateral JJ cord-258172-p54j4zzo 228 20 pneumonia pneumonia NN cord-258172-p54j4zzo 228 21 that that WDT cord-258172-p54j4zzo 228 22 is be VBZ cord-258172-p54j4zzo 228 23 common common JJ cord-258172-p54j4zzo 228 24 for for IN cord-258172-p54j4zzo 228 25 SARS SARS NNP cord-258172-p54j4zzo 228 26 - - HYPH cord-258172-p54j4zzo 228 27 diseases disease NNS cord-258172-p54j4zzo 228 28 [ [ -LRB- cord-258172-p54j4zzo 228 29 70 70 CD cord-258172-p54j4zzo 228 30 ] ] -RRB- cord-258172-p54j4zzo 228 31 . . . cord-258172-p54j4zzo 229 1 This this DT cord-258172-p54j4zzo 229 2 pathogenic pathogenic JJ cord-258172-p54j4zzo 229 3 mechanism mechanism NN cord-258172-p54j4zzo 229 4 is be VBZ cord-258172-p54j4zzo 229 5 supported support VBN cord-258172-p54j4zzo 229 6 by by IN cord-258172-p54j4zzo 229 7 previous previous JJ cord-258172-p54j4zzo 229 8 findings finding NNS cord-258172-p54j4zzo 229 9 , , , cord-258172-p54j4zzo 229 10 showing show VBG cord-258172-p54j4zzo 229 11 that that IN cord-258172-p54j4zzo 229 12 early early JJ cord-258172-p54j4zzo 229 13 disease disease NN cord-258172-p54j4zzo 229 14 is be VBZ cord-258172-p54j4zzo 229 15 manifested manifest VBN cord-258172-p54j4zzo 229 16 as as IN cord-258172-p54j4zzo 229 17 a a DT cord-258172-p54j4zzo 229 18 bronchiolar bronchiolar JJ cord-258172-p54j4zzo 229 19 disease disease NN cord-258172-p54j4zzo 229 20 with with IN cord-258172-p54j4zzo 229 21 respiratory respiratory JJ cord-258172-p54j4zzo 229 22 epithelial epithelial JJ cord-258172-p54j4zzo 229 23 cell cell NN cord-258172-p54j4zzo 229 24 necrosis necrosis NN cord-258172-p54j4zzo 229 25 , , , cord-258172-p54j4zzo 229 26 loss loss NN cord-258172-p54j4zzo 229 27 of of IN cord-258172-p54j4zzo 229 28 cilia cilia NN cord-258172-p54j4zzo 229 29 , , , cord-258172-p54j4zzo 229 30 squamous squamous JJ cord-258172-p54j4zzo 229 31 cell cell NN cord-258172-p54j4zzo 229 32 metaplasia metaplasia NN cord-258172-p54j4zzo 229 33 , , , cord-258172-p54j4zzo 229 34 and and CC cord-258172-p54j4zzo 229 35 intrabronchiolar intrabronchiolar JJ cord-258172-p54j4zzo 229 36 fibrin fibrin NN cord-258172-p54j4zzo 229 37 deposits deposit NNS cord-258172-p54j4zzo 229 38 [ [ -LRB- cord-258172-p54j4zzo 229 39 32 32 CD cord-258172-p54j4zzo 229 40 ] ] -RRB- cord-258172-p54j4zzo 229 41 . . . cord-258172-p54j4zzo 230 1 In in IN cord-258172-p54j4zzo 230 2 fact fact NN cord-258172-p54j4zzo 230 3 , , , cord-258172-p54j4zzo 230 4 it -PRON- PRP cord-258172-p54j4zzo 230 5 has have VBZ cord-258172-p54j4zzo 230 6 been be VBN cord-258172-p54j4zzo 230 7 suggested suggest VBN cord-258172-p54j4zzo 230 8 that that IN cord-258172-p54j4zzo 230 9 early early JJ cord-258172-p54j4zzo 230 10 diffuse diffuse JJ cord-258172-p54j4zzo 230 11 damage damage NN cord-258172-p54j4zzo 230 12 as as IN cord-258172-p54j4zzo 230 13 a a DT cord-258172-p54j4zzo 230 14 result result NN cord-258172-p54j4zzo 230 15 of of IN cord-258172-p54j4zzo 230 16 SARS SARS NNP cord-258172-p54j4zzo 230 17 - - HYPH cord-258172-p54j4zzo 230 18 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 230 19 infection infection NN cord-258172-p54j4zzo 230 20 may may MD cord-258172-p54j4zzo 230 21 actually actually RB cord-258172-p54j4zzo 230 22 initiate initiate VB cord-258172-p54j4zzo 230 23 at at IN cord-258172-p54j4zzo 230 24 the the DT cord-258172-p54j4zzo 230 25 level level NN cord-258172-p54j4zzo 230 26 of of IN cord-258172-p54j4zzo 230 27 the the DT cord-258172-p54j4zzo 230 28 respiratory respiratory JJ cord-258172-p54j4zzo 230 29 bronchioles bronchiole NNS cord-258172-p54j4zzo 230 30 [ [ -LRB- cord-258172-p54j4zzo 230 31 71 71 CD cord-258172-p54j4zzo 230 32 , , , cord-258172-p54j4zzo 230 33 72 72 CD cord-258172-p54j4zzo 230 34 ] ] -RRB- cord-258172-p54j4zzo 230 35 . . . cord-258172-p54j4zzo 231 1 Our -PRON- PRP$ cord-258172-p54j4zzo 231 2 findings finding NNS cord-258172-p54j4zzo 231 3 confirm confirm VBP cord-258172-p54j4zzo 231 4 that that IN cord-258172-p54j4zzo 231 5 the the DT cord-258172-p54j4zzo 231 6 respiratory respiratory JJ cord-258172-p54j4zzo 231 7 tract tract NN cord-258172-p54j4zzo 231 8 tissues tissue NNS cord-258172-p54j4zzo 231 9 have have VBP cord-258172-p54j4zzo 231 10 quite quite RB cord-258172-p54j4zzo 231 11 limited limited JJ cord-258172-p54j4zzo 231 12 expression expression NN cord-258172-p54j4zzo 231 13 levels level NNS cord-258172-p54j4zzo 231 14 of of IN cord-258172-p54j4zzo 231 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 231 16 compared compare VBN cord-258172-p54j4zzo 231 17 to to IN cord-258172-p54j4zzo 231 18 several several JJ cord-258172-p54j4zzo 231 19 other other JJ cord-258172-p54j4zzo 231 20 tissues tissue NNS cord-258172-p54j4zzo 231 21 that that WDT cord-258172-p54j4zzo 231 22 show show VBP cord-258172-p54j4zzo 231 23 much much RB cord-258172-p54j4zzo 231 24 more more RBR cord-258172-p54j4zzo 231 25 prominent prominent JJ cord-258172-p54j4zzo 231 26 signal signal NN cord-258172-p54j4zzo 231 27 . . . cord-258172-p54j4zzo 232 1 Because because IN cord-258172-p54j4zzo 232 2 ACE2 ACE2 NNP cord-258172-p54j4zzo 232 3 is be VBZ cord-258172-p54j4zzo 232 4 highly highly RB cord-258172-p54j4zzo 232 5 expressed express VBN cord-258172-p54j4zzo 232 6 in in IN cord-258172-p54j4zzo 232 7 the the DT cord-258172-p54j4zzo 232 8 intestine intestine NN cord-258172-p54j4zzo 232 9 [ [ -LRB- cord-258172-p54j4zzo 232 10 29 29 CD cord-258172-p54j4zzo 232 11 ] ] -RRB- cord-258172-p54j4zzo 232 12 , , , cord-258172-p54j4zzo 232 13 as as IN cord-258172-p54j4zzo 232 14 also also RB cord-258172-p54j4zzo 232 15 confirmed confirm VBN cord-258172-p54j4zzo 232 16 by by IN cord-258172-p54j4zzo 232 17 our -PRON- PRP$ cord-258172-p54j4zzo 232 18 bioinformatics bioinformatics NN cord-258172-p54j4zzo 232 19 study study NN cord-258172-p54j4zzo 232 20 , , , cord-258172-p54j4zzo 232 21 it -PRON- PRP cord-258172-p54j4zzo 232 22 would would MD cord-258172-p54j4zzo 232 23 be be VB cord-258172-p54j4zzo 232 24 obvious obvious JJ cord-258172-p54j4zzo 232 25 to to TO cord-258172-p54j4zzo 232 26 predict predict VB cord-258172-p54j4zzo 232 27 that that IN cord-258172-p54j4zzo 232 28 both both DT cord-258172-p54j4zzo 232 29 SARS SARS NNP cord-258172-p54j4zzo 232 30 - - HYPH cord-258172-p54j4zzo 232 31 CoV-1 CoV-1 NNP cord-258172-p54j4zzo 232 32 and and CC cord-258172-p54j4zzo 232 33 -2 -2 CD cord-258172-p54j4zzo 232 34 infections infection NNS cord-258172-p54j4zzo 232 35 cause cause VBP cord-258172-p54j4zzo 232 36 significant significant JJ cord-258172-p54j4zzo 232 37 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 232 38 pathology pathology NN cord-258172-p54j4zzo 232 39 and and CC cord-258172-p54j4zzo 232 40 symptoms symptom NNS cord-258172-p54j4zzo 232 41 including include VBG cord-258172-p54j4zzo 232 42 diarrhea diarrhea NN cord-258172-p54j4zzo 232 43 . . . cord-258172-p54j4zzo 233 1 Interestingly interestingly RB cord-258172-p54j4zzo 233 2 , , , cord-258172-p54j4zzo 233 3 the the DT cord-258172-p54j4zzo 233 4 patients patient NNS cord-258172-p54j4zzo 233 5 with with IN cord-258172-p54j4zzo 233 6 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 233 7 have have VBP cord-258172-p54j4zzo 233 8 reported report VBN cord-258172-p54j4zzo 233 9 less less JJR cord-258172-p54j4zzo 233 10 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 233 11 symptoms symptom NNS cord-258172-p54j4zzo 233 12 than than IN cord-258172-p54j4zzo 233 13 the the DT cord-258172-p54j4zzo 233 14 SARS SARS NNP cord-258172-p54j4zzo 233 15 - - HYPH cord-258172-p54j4zzo 233 16 CoV-1-infected cov-1-infecte VBN cord-258172-p54j4zzo 233 17 patients patient NNS cord-258172-p54j4zzo 233 18 [ [ -LRB- cord-258172-p54j4zzo 233 19 22 22 CD cord-258172-p54j4zzo 233 20 , , , cord-258172-p54j4zzo 233 21 30 30 CD cord-258172-p54j4zzo 233 22 ] ] -RRB- cord-258172-p54j4zzo 233 23 . . . cord-258172-p54j4zzo 234 1 The the DT cord-258172-p54j4zzo 234 2 pathophysiological pathophysiological JJ cord-258172-p54j4zzo 234 3 basis basis NN cord-258172-p54j4zzo 234 4 for for IN cord-258172-p54j4zzo 234 5 this this DT cord-258172-p54j4zzo 234 6 phenomenon phenomenon NN cord-258172-p54j4zzo 234 7 is be VBZ cord-258172-p54j4zzo 234 8 not not RB cord-258172-p54j4zzo 234 9 understood understand VBN cord-258172-p54j4zzo 234 10 at at IN cord-258172-p54j4zzo 234 11 this this DT cord-258172-p54j4zzo 234 12 point point NN cord-258172-p54j4zzo 234 13 , , , cord-258172-p54j4zzo 234 14 and and CC cord-258172-p54j4zzo 234 15 thus thus RB cord-258172-p54j4zzo 234 16 further further JJ cord-258172-p54j4zzo 234 17 investigations investigation NNS cord-258172-p54j4zzo 234 18 on on IN cord-258172-p54j4zzo 234 19 this this DT cord-258172-p54j4zzo 234 20 topic topic NN cord-258172-p54j4zzo 234 21 are be VBP cord-258172-p54j4zzo 234 22 warranted warrant VBN cord-258172-p54j4zzo 234 23 . . . cord-258172-p54j4zzo 235 1 When when WRB cord-258172-p54j4zzo 235 2 we -PRON- PRP cord-258172-p54j4zzo 235 3 initiated initiate VBD cord-258172-p54j4zzo 235 4 the the DT cord-258172-p54j4zzo 235 5 present present JJ cord-258172-p54j4zzo 235 6 study study NN cord-258172-p54j4zzo 235 7 , , , cord-258172-p54j4zzo 235 8 we -PRON- PRP cord-258172-p54j4zzo 235 9 hypothesized hypothesize VBD cord-258172-p54j4zzo 235 10 that that IN cord-258172-p54j4zzo 235 11 understanding understand VBG cord-258172-p54j4zzo 235 12 better well RBR cord-258172-p54j4zzo 235 13 the the DT cord-258172-p54j4zzo 235 14 transcriptional transcriptional JJ cord-258172-p54j4zzo 235 15 regulation regulation NN cord-258172-p54j4zzo 235 16 of of IN cord-258172-p54j4zzo 235 17 the the DT cord-258172-p54j4zzo 235 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 235 19 gene gene NN cord-258172-p54j4zzo 235 20 might may MD cord-258172-p54j4zzo 235 21 help help VB cord-258172-p54j4zzo 235 22 to to TO cord-258172-p54j4zzo 235 23 explain explain VB cord-258172-p54j4zzo 235 24 the the DT cord-258172-p54j4zzo 235 25 peculiar peculiar JJ cord-258172-p54j4zzo 235 26 distribution distribution NN cord-258172-p54j4zzo 235 27 pattern pattern NN cord-258172-p54j4zzo 235 28 of of IN cord-258172-p54j4zzo 235 29 ACE2 ACE2 NNP cord-258172-p54j4zzo 235 30 in in IN cord-258172-p54j4zzo 235 31 tissues tissue NNS cord-258172-p54j4zzo 235 32 . . . cord-258172-p54j4zzo 236 1 Since since IN cord-258172-p54j4zzo 236 2 upregulation upregulation NN cord-258172-p54j4zzo 236 3 of of IN cord-258172-p54j4zzo 236 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 236 5 would would MD cord-258172-p54j4zzo 236 6 reflect reflect VB cord-258172-p54j4zzo 236 7 an an DT cord-258172-p54j4zzo 236 8 increased increase VBN cord-258172-p54j4zzo 236 9 number number NN cord-258172-p54j4zzo 236 10 of of IN cord-258172-p54j4zzo 236 11 SARScoronavirus SARScoronavirus NNP cord-258172-p54j4zzo 236 12 receptors receptor NNS cord-258172-p54j4zzo 236 13 on on IN cord-258172-p54j4zzo 236 14 cell cell NN cord-258172-p54j4zzo 236 15 surfaces surface NNS cord-258172-p54j4zzo 236 16 , , , cord-258172-p54j4zzo 236 17 it -PRON- PRP cord-258172-p54j4zzo 236 18 could could MD cord-258172-p54j4zzo 236 19 possibly possibly RB cord-258172-p54j4zzo 236 20 help help VB cord-258172-p54j4zzo 236 21 us -PRON- PRP cord-258172-p54j4zzo 236 22 to to TO cord-258172-p54j4zzo 236 23 understand understand VB cord-258172-p54j4zzo 236 24 the the DT cord-258172-p54j4zzo 236 25 mechanisms mechanism NNS cord-258172-p54j4zzo 236 26 why why WRB cord-258172-p54j4zzo 236 27 certain certain JJ cord-258172-p54j4zzo 236 28 patients patient NNS cord-258172-p54j4zzo 236 29 ( ( -LRB- cord-258172-p54j4zzo 236 30 males male NNS cord-258172-p54j4zzo 236 31 more more RBR cord-258172-p54j4zzo 236 32 than than IN cord-258172-p54j4zzo 236 33 females female NNS cord-258172-p54j4zzo 236 34 , , , cord-258172-p54j4zzo 236 35 old old JJ cord-258172-p54j4zzo 236 36 more more RBR cord-258172-p54j4zzo 236 37 than than IN cord-258172-p54j4zzo 236 38 young young JJ cord-258172-p54j4zzo 236 39 , , , cord-258172-p54j4zzo 236 40 smokers smoker NNS cord-258172-p54j4zzo 236 41 more more JJR cord-258172-p54j4zzo 236 42 than than IN cord-258172-p54j4zzo 236 43 non non JJ cord-258172-p54j4zzo 236 44 - - NNS cord-258172-p54j4zzo 236 45 smokers smoker NNS cord-258172-p54j4zzo 236 46 ) ) -RRB- cord-258172-p54j4zzo 236 47 are be VBP cord-258172-p54j4zzo 236 48 more more RBR cord-258172-p54j4zzo 236 49 susceptible susceptible JJ cord-258172-p54j4zzo 236 50 to to IN cord-258172-p54j4zzo 236 51 the the DT cord-258172-p54j4zzo 236 52 most most RBS cord-258172-p54j4zzo 236 53 detrimental detrimental JJ cord-258172-p54j4zzo 236 54 effects effect NNS cord-258172-p54j4zzo 236 55 of of IN cord-258172-p54j4zzo 236 56 the the DT cord-258172-p54j4zzo 236 57 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 236 58 infection infection NN cord-258172-p54j4zzo 236 59 . . . cord-258172-p54j4zzo 237 1 In in IN cord-258172-p54j4zzo 237 2 our -PRON- PRP$ cord-258172-p54j4zzo 237 3 study study NN cord-258172-p54j4zzo 237 4 , , , cord-258172-p54j4zzo 237 5 the the DT cord-258172-p54j4zzo 237 6 signals signal NNS cord-258172-p54j4zzo 237 7 for for IN cord-258172-p54j4zzo 237 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 237 9 mRNA mRNA NNP cord-258172-p54j4zzo 237 10 in in IN cord-258172-p54j4zzo 237 11 the the DT cord-258172-p54j4zzo 237 12 lung lung NN cord-258172-p54j4zzo 237 13 specimens specimen NNS cord-258172-p54j4zzo 237 14 did do VBD cord-258172-p54j4zzo 237 15 not not RB cord-258172-p54j4zzo 237 16 vary vary VB cord-258172-p54j4zzo 237 17 much much RB cord-258172-p54j4zzo 237 18 in in IN cord-258172-p54j4zzo 237 19 different different JJ cord-258172-p54j4zzo 237 20 age age NN cord-258172-p54j4zzo 237 21 groups group NNS cord-258172-p54j4zzo 237 22 nor nor CC cord-258172-p54j4zzo 237 23 did do VBD cord-258172-p54j4zzo 237 24 they -PRON- PRP cord-258172-p54j4zzo 237 25 show show VB cord-258172-p54j4zzo 237 26 significant significant JJ cord-258172-p54j4zzo 237 27 differences difference NNS cord-258172-p54j4zzo 237 28 between between IN cord-258172-p54j4zzo 237 29 males male NNS cord-258172-p54j4zzo 237 30 and and CC cord-258172-p54j4zzo 237 31 females female NNS cord-258172-p54j4zzo 237 32 , , , cord-258172-p54j4zzo 237 33 which which WDT cord-258172-p54j4zzo 237 34 is be VBZ cord-258172-p54j4zzo 237 35 in in IN cord-258172-p54j4zzo 237 36 line line NN cord-258172-p54j4zzo 237 37 with with IN cord-258172-p54j4zzo 237 38 previous previous JJ cord-258172-p54j4zzo 237 39 findings finding NNS cord-258172-p54j4zzo 237 40 [ [ -LRB- cord-258172-p54j4zzo 237 41 65 65 CD cord-258172-p54j4zzo 237 42 ] ] -RRB- cord-258172-p54j4zzo 237 43 . . . cord-258172-p54j4zzo 238 1 Therefore therefore RB cord-258172-p54j4zzo 238 2 , , , cord-258172-p54j4zzo 238 3 different different JJ cord-258172-p54j4zzo 238 4 expression expression NN cord-258172-p54j4zzo 238 5 levels level NNS cord-258172-p54j4zzo 238 6 of of IN cord-258172-p54j4zzo 238 7 lung lung NN cord-258172-p54j4zzo 238 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 238 9 may may MD cord-258172-p54j4zzo 238 10 not not RB cord-258172-p54j4zzo 238 11 explain explain VB cord-258172-p54j4zzo 238 12 the the DT cord-258172-p54j4zzo 238 13 variable variable JJ cord-258172-p54j4zzo 238 14 outcome outcome NN cord-258172-p54j4zzo 238 15 of of IN cord-258172-p54j4zzo 238 16 the the DT cord-258172-p54j4zzo 238 17 disease disease NN cord-258172-p54j4zzo 238 18 concerning concern VBG cord-258172-p54j4zzo 238 19 age age NN cord-258172-p54j4zzo 238 20 groups group NNS cord-258172-p54j4zzo 238 21 and and CC cord-258172-p54j4zzo 238 22 genders gender NNS cord-258172-p54j4zzo 238 23 . . . cord-258172-p54j4zzo 239 1 Importantly importantly RB cord-258172-p54j4zzo 239 2 , , , cord-258172-p54j4zzo 239 3 our -PRON- PRP$ cord-258172-p54j4zzo 239 4 studies study NNS cord-258172-p54j4zzo 239 5 on on IN cord-258172-p54j4zzo 239 6 this this DT cord-258172-p54j4zzo 239 7 aspect aspect NN cord-258172-p54j4zzo 239 8 were be VBD cord-258172-p54j4zzo 239 9 performed perform VBN cord-258172-p54j4zzo 239 10 using use VBG cord-258172-p54j4zzo 239 11 whole whole JJ cord-258172-p54j4zzo 239 12 tissue tissue NN cord-258172-p54j4zzo 239 13 RNA RNA NNP cord-258172-p54j4zzo 239 14 - - HYPH cord-258172-p54j4zzo 239 15 Seq seq NN cord-258172-p54j4zzo 239 16 values value NNS cord-258172-p54j4zzo 239 17 , , , cord-258172-p54j4zzo 239 18 and and CC cord-258172-p54j4zzo 239 19 at at RB cord-258172-p54j4zzo 239 20 least least RBS cord-258172-p54j4zzo 239 21 one one CD cord-258172-p54j4zzo 239 22 other other JJ cord-258172-p54j4zzo 239 23 analysis analysis NN cord-258172-p54j4zzo 239 24 using use VBG cord-258172-p54j4zzo 239 25 single single JJ cord-258172-p54j4zzo 239 26 - - HYPH cord-258172-p54j4zzo 239 27 cell cell NN cord-258172-p54j4zzo 239 28 RNA RNA NNP cord-258172-p54j4zzo 239 29 - - HYPH cord-258172-p54j4zzo 239 30 Seq Seq NNP cord-258172-p54j4zzo 239 31 data datum NNS cord-258172-p54j4zzo 239 32 has have VBZ cord-258172-p54j4zzo 239 33 identified identify VBN cord-258172-p54j4zzo 239 34 changes change NNS cord-258172-p54j4zzo 239 35 in in IN cord-258172-p54j4zzo 239 36 ACE2 ACE2 NNP cord-258172-p54j4zzo 239 37 expression expression NN cord-258172-p54j4zzo 239 38 associated associate VBN cord-258172-p54j4zzo 239 39 age age NN cord-258172-p54j4zzo 239 40 , , , cord-258172-p54j4zzo 239 41 sex sex NN cord-258172-p54j4zzo 239 42 , , , cord-258172-p54j4zzo 239 43 and and CC cord-258172-p54j4zzo 239 44 smoking smoking NN cord-258172-p54j4zzo 239 45 status status NN cord-258172-p54j4zzo 239 46 for for IN cord-258172-p54j4zzo 239 47 various various JJ cord-258172-p54j4zzo 239 48 cell cell NN cord-258172-p54j4zzo 239 49 types type NNS cord-258172-p54j4zzo 239 50 [ [ -LRB- cord-258172-p54j4zzo 239 51 73 73 CD cord-258172-p54j4zzo 239 52 ] ] -RRB- cord-258172-p54j4zzo 239 53 . . . cord-258172-p54j4zzo 240 1 Specifically specifically RB cord-258172-p54j4zzo 240 2 , , , cord-258172-p54j4zzo 240 3 they -PRON- PRP cord-258172-p54j4zzo 240 4 have have VBP cord-258172-p54j4zzo 240 5 found find VBN cord-258172-p54j4zzo 240 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 240 7 expression expression NN cord-258172-p54j4zzo 240 8 to to TO cord-258172-p54j4zzo 240 9 increase increase VB cord-258172-p54j4zzo 240 10 with with IN cord-258172-p54j4zzo 240 11 age age NN cord-258172-p54j4zzo 240 12 in in IN cord-258172-p54j4zzo 240 13 basal basal NN cord-258172-p54j4zzo 240 14 and and CC cord-258172-p54j4zzo 240 15 multiciliated multiciliated JJ cord-258172-p54j4zzo 240 16 cells cell NNS cord-258172-p54j4zzo 240 17 , , , cord-258172-p54j4zzo 240 18 and and CC cord-258172-p54j4zzo 240 19 higher high JJR cord-258172-p54j4zzo 240 20 expression expression NN cord-258172-p54j4zzo 240 21 for for IN cord-258172-p54j4zzo 240 22 males male NNS cord-258172-p54j4zzo 240 23 in in IN cord-258172-p54j4zzo 240 24 airway airway NN cord-258172-p54j4zzo 240 25 secretory secretory NN cord-258172-p54j4zzo 240 26 cells cell NNS cord-258172-p54j4zzo 240 27 and and CC cord-258172-p54j4zzo 240 28 alveolar alveolar NN cord-258172-p54j4zzo 240 29 AT2 at2 NN cord-258172-p54j4zzo 240 30 cells cell NNS cord-258172-p54j4zzo 240 31 . . . cord-258172-p54j4zzo 241 1 Additionally additionally RB cord-258172-p54j4zzo 241 2 , , , cord-258172-p54j4zzo 241 3 a a DT cord-258172-p54j4zzo 241 4 study study NN cord-258172-p54j4zzo 241 5 of of IN cord-258172-p54j4zzo 241 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 241 7 expression expression NN cord-258172-p54j4zzo 241 8 in in IN cord-258172-p54j4zzo 241 9 nasal nasal NN cord-258172-p54j4zzo 241 10 epithelium epithelium NN cord-258172-p54j4zzo 241 11 ( ( -LRB- cord-258172-p54j4zzo 241 12 not not RB cord-258172-p54j4zzo 241 13 included include VBN cord-258172-p54j4zzo 241 14 in in IN cord-258172-p54j4zzo 241 15 GTEx gtex NN cord-258172-p54j4zzo 241 16 dataset dataset NN cord-258172-p54j4zzo 241 17 ) ) -RRB- cord-258172-p54j4zzo 241 18 showed show VBD cord-258172-p54j4zzo 241 19 lowest low JJS cord-258172-p54j4zzo 241 20 levels level NNS cord-258172-p54j4zzo 241 21 in in IN cord-258172-p54j4zzo 241 22 young young JJ cord-258172-p54j4zzo 241 23 children child NNS cord-258172-p54j4zzo 241 24 ( ( -LRB- cord-258172-p54j4zzo 241 25 < < NNP cord-258172-p54j4zzo 241 26 10 10 CD cord-258172-p54j4zzo 241 27 ) ) -RRB- cord-258172-p54j4zzo 241 28 with with IN cord-258172-p54j4zzo 241 29 increasing increase VBG cord-258172-p54j4zzo 241 30 values value NNS cord-258172-p54j4zzo 241 31 in in IN cord-258172-p54j4zzo 241 32 later later JJ cord-258172-p54j4zzo 241 33 age age NN cord-258172-p54j4zzo 241 34 groups group NNS cord-258172-p54j4zzo 241 35 [ [ -LRB- cord-258172-p54j4zzo 241 36 74 74 CD cord-258172-p54j4zzo 241 37 ] ] -RRB- cord-258172-p54j4zzo 241 38 . . . cord-258172-p54j4zzo 242 1 It -PRON- PRP cord-258172-p54j4zzo 242 2 has have VBZ cord-258172-p54j4zzo 242 3 been be VBN cord-258172-p54j4zzo 242 4 recently recently RB cord-258172-p54j4zzo 242 5 discussed discuss VBN cord-258172-p54j4zzo 242 6 that that IN cord-258172-p54j4zzo 242 7 different different JJ cord-258172-p54j4zzo 242 8 innate innate JJ cord-258172-p54j4zzo 242 9 and and CC cord-258172-p54j4zzo 242 10 adaptive adaptive JJ cord-258172-p54j4zzo 242 11 immune immune JJ cord-258172-p54j4zzo 242 12 responses response NNS cord-258172-p54j4zzo 242 13 related relate VBN cord-258172-p54j4zzo 242 14 to to IN cord-258172-p54j4zzo 242 15 both both DT cord-258172-p54j4zzo 242 16 age age NN cord-258172-p54j4zzo 242 17 and and CC cord-258172-p54j4zzo 242 18 gender gender NN cord-258172-p54j4zzo 242 19 may may MD cord-258172-p54j4zzo 242 20 contribute contribute VB cord-258172-p54j4zzo 242 21 to to IN cord-258172-p54j4zzo 242 22 variable variable JJ cord-258172-p54j4zzo 242 23 outcome outcome NN cord-258172-p54j4zzo 242 24 of of IN cord-258172-p54j4zzo 242 25 severe severe JJ cord-258172-p54j4zzo 242 26 viral viral JJ cord-258172-p54j4zzo 242 27 diseases disease NNS cord-258172-p54j4zzo 242 28 [ [ -LRB- cord-258172-p54j4zzo 242 29 35 35 CD cord-258172-p54j4zzo 242 30 ] ] -RRB- cord-258172-p54j4zzo 242 31 . . . cord-258172-p54j4zzo 243 1 It -PRON- PRP cord-258172-p54j4zzo 243 2 is be VBZ cord-258172-p54j4zzo 243 3 clearly clearly RB cord-258172-p54j4zzo 243 4 one one CD cord-258172-p54j4zzo 243 5 major major JJ cord-258172-p54j4zzo 243 6 research research NN cord-258172-p54j4zzo 243 7 area area NN cord-258172-p54j4zzo 243 8 to to TO cord-258172-p54j4zzo 243 9 be be VB cord-258172-p54j4zzo 243 10 followed follow VBN cord-258172-p54j4zzo 243 11 regarding regard VBG cord-258172-p54j4zzo 243 12 COVID-19 covid-19 CD cord-258172-p54j4zzo 243 13 infection infection NN cord-258172-p54j4zzo 243 14 . . . cord-258172-p54j4zzo 244 1 To to TO cord-258172-p54j4zzo 244 2 investigate investigate VB cord-258172-p54j4zzo 244 3 the the DT cord-258172-p54j4zzo 244 4 transcriptional transcriptional JJ cord-258172-p54j4zzo 244 5 regulation regulation NN cord-258172-p54j4zzo 244 6 of of IN cord-258172-p54j4zzo 244 7 the the DT cord-258172-p54j4zzo 244 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 244 9 gene gene NN cord-258172-p54j4zzo 244 10 we -PRON- PRP cord-258172-p54j4zzo 244 11 made make VBD cord-258172-p54j4zzo 244 12 predictions prediction NNS cord-258172-p54j4zzo 244 13 for for IN cord-258172-p54j4zzo 244 14 the the DT cord-258172-p54j4zzo 244 15 binding bind VBG cord-258172-p54j4zzo 244 16 sites site NNS cord-258172-p54j4zzo 244 17 of of IN cord-258172-p54j4zzo 244 18 transcription transcription NN cord-258172-p54j4zzo 244 19 factors factor NNS cord-258172-p54j4zzo 244 20 within within IN cord-258172-p54j4zzo 244 21 the the DT cord-258172-p54j4zzo 244 22 proximal proximal JJ cord-258172-p54j4zzo 244 23 promoter promoter NN cord-258172-p54j4zzo 244 24 region region NN cord-258172-p54j4zzo 244 25 of of IN cord-258172-p54j4zzo 244 26 the the DT cord-258172-p54j4zzo 244 27 intestine intestine NN cord-258172-p54j4zzo 244 28 - - HYPH cord-258172-p54j4zzo 244 29 specific specific JJ cord-258172-p54j4zzo 244 30 and and CC cord-258172-p54j4zzo 244 31 lung lung NN cord-258172-p54j4zzo 244 32 - - HYPH cord-258172-p54j4zzo 244 33 specific specific JJ cord-258172-p54j4zzo 244 34 human human JJ cord-258172-p54j4zzo 244 35 ACE2 ACE2 NNP cord-258172-p54j4zzo 244 36 transcript transcript NN cord-258172-p54j4zzo 244 37 promoters promoter NNS cord-258172-p54j4zzo 244 38 . . . cord-258172-p54j4zzo 245 1 Our -PRON- PRP$ cord-258172-p54j4zzo 245 2 findings finding NNS cord-258172-p54j4zzo 245 3 introduced introduce VBD cord-258172-p54j4zzo 245 4 several several JJ cord-258172-p54j4zzo 245 5 putative putative JJ cord-258172-p54j4zzo 245 6 binding bind VBG cord-258172-p54j4zzo 245 7 sites site NNS cord-258172-p54j4zzo 245 8 in in IN cord-258172-p54j4zzo 245 9 the the DT cord-258172-p54j4zzo 245 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 245 11 promoter promoter NN cord-258172-p54j4zzo 245 12 for for IN cord-258172-p54j4zzo 245 13 known know VBN cord-258172-p54j4zzo 245 14 transcription transcription NN cord-258172-p54j4zzo 245 15 factors factor NNS cord-258172-p54j4zzo 245 16 , , , cord-258172-p54j4zzo 245 17 which which WDT cord-258172-p54j4zzo 245 18 showed show VBD cord-258172-p54j4zzo 245 19 high high JJ cord-258172-p54j4zzo 245 20 levels level NNS cord-258172-p54j4zzo 245 21 of of IN cord-258172-p54j4zzo 245 22 coexpression coexpression NN cord-258172-p54j4zzo 245 23 with with IN cord-258172-p54j4zzo 245 24 ACE2 ACE2 NNP cord-258172-p54j4zzo 245 25 in in IN cord-258172-p54j4zzo 245 26 several several JJ cord-258172-p54j4zzo 245 27 tissues tissue NNS cord-258172-p54j4zzo 245 28 including include VBG cord-258172-p54j4zzo 245 29 the the DT cord-258172-p54j4zzo 245 30 ileum ileum NN cord-258172-p54j4zzo 245 31 , , , cord-258172-p54j4zzo 245 32 colon colon NN cord-258172-p54j4zzo 245 33 , , , cord-258172-p54j4zzo 245 34 and and CC cord-258172-p54j4zzo 245 35 kidney kidney NN cord-258172-p54j4zzo 245 36 . . . cord-258172-p54j4zzo 246 1 The the DT cord-258172-p54j4zzo 246 2 identified identify VBN cord-258172-p54j4zzo 246 3 transcription transcription NN cord-258172-p54j4zzo 246 4 factors factor NNS cord-258172-p54j4zzo 246 5 could could MD cord-258172-p54j4zzo 246 6 represent represent VB cord-258172-p54j4zzo 246 7 potential potential JJ cord-258172-p54j4zzo 246 8 candidate candidate NN cord-258172-p54j4zzo 246 9 target target NN cord-258172-p54j4zzo 246 10 molecules molecule NNS cord-258172-p54j4zzo 246 11 which which WDT cord-258172-p54j4zzo 246 12 regulate regulate VBP cord-258172-p54j4zzo 246 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 246 14 expression expression NN cord-258172-p54j4zzo 246 15 . . . cord-258172-p54j4zzo 247 1 Two two CD cord-258172-p54j4zzo 247 2 of of IN cord-258172-p54j4zzo 247 3 our -PRON- PRP$ cord-258172-p54j4zzo 247 4 predictions prediction NNS cord-258172-p54j4zzo 247 5 , , , cord-258172-p54j4zzo 247 6 for for IN cord-258172-p54j4zzo 247 7 HNF1A hnf1a CD cord-258172-p54j4zzo 247 8 and and CC cord-258172-p54j4zzo 247 9 HNF1B hnf1b NN cord-258172-p54j4zzo 247 10 , , , cord-258172-p54j4zzo 247 11 have have VBP cord-258172-p54j4zzo 247 12 been be VBN cord-258172-p54j4zzo 247 13 previously previously RB cord-258172-p54j4zzo 247 14 identified identify VBN cord-258172-p54j4zzo 247 15 experimentally experimentally RB cord-258172-p54j4zzo 247 16 to to TO cord-258172-p54j4zzo 247 17 drive drive VB cord-258172-p54j4zzo 247 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 247 19 expression expression NN cord-258172-p54j4zzo 247 20 in in IN cord-258172-p54j4zzo 247 21 pancreatic pancreatic JJ cord-258172-p54j4zzo 247 22 islet islet NN cord-258172-p54j4zzo 247 23 cells cell NNS cord-258172-p54j4zzo 247 24 and and CC cord-258172-p54j4zzo 247 25 insulinoma insulinoma NN cord-258172-p54j4zzo 247 26 cells cell NNS cord-258172-p54j4zzo 247 27 , , , cord-258172-p54j4zzo 247 28 respectively respectively RB cord-258172-p54j4zzo 247 29 [ [ -LRB- cord-258172-p54j4zzo 247 30 49 49 CD cord-258172-p54j4zzo 247 31 ] ] -RRB- cord-258172-p54j4zzo 247 32 . . . cord-258172-p54j4zzo 248 1 Later later RB cord-258172-p54j4zzo 248 2 work work NN cord-258172-p54j4zzo 248 3 by by IN cord-258172-p54j4zzo 248 4 the the DT cord-258172-p54j4zzo 248 5 same same JJ cord-258172-p54j4zzo 248 6 group group NN cord-258172-p54j4zzo 248 7 has have VBZ cord-258172-p54j4zzo 248 8 shown show VBN cord-258172-p54j4zzo 248 9 that that IN cord-258172-p54j4zzo 248 10 our -PRON- PRP$ cord-258172-p54j4zzo 248 11 prediction prediction NN cord-258172-p54j4zzo 248 12 of of IN cord-258172-p54j4zzo 248 13 FOXA FOXA NNP cord-258172-p54j4zzo 248 14 binding bind VBG cord-258172-p54j4zzo 248 15 sites site NNS cord-258172-p54j4zzo 248 16 in in IN cord-258172-p54j4zzo 248 17 the the DT cord-258172-p54j4zzo 248 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 248 19 promoter promoter NN cord-258172-p54j4zzo 248 20 are be VBP cord-258172-p54j4zzo 248 21 also also RB cord-258172-p54j4zzo 248 22 likely likely RB cord-258172-p54j4zzo 248 23 correct correct JJ cord-258172-p54j4zzo 248 24 [ [ -LRB- cord-258172-p54j4zzo 248 25 75 75 CD cord-258172-p54j4zzo 248 26 ] ] -RRB- cord-258172-p54j4zzo 248 27 . . . cord-258172-p54j4zzo 249 1 It -PRON- PRP cord-258172-p54j4zzo 249 2 is be VBZ cord-258172-p54j4zzo 249 3 of of IN cord-258172-p54j4zzo 249 4 interest interest NN cord-258172-p54j4zzo 249 5 that that WDT cord-258172-p54j4zzo 249 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 249 7 might may MD cord-258172-p54j4zzo 249 8 be be VB cord-258172-p54j4zzo 249 9 regulated regulate VBN cord-258172-p54j4zzo 249 10 by by IN cord-258172-p54j4zzo 249 11 oxygen oxygen NN cord-258172-p54j4zzo 249 12 status status NN cord-258172-p54j4zzo 249 13 . . . cord-258172-p54j4zzo 250 1 Zhang Zhang NNP cord-258172-p54j4zzo 250 2 and and CC cord-258172-p54j4zzo 250 3 coworkers coworker NNS cord-258172-p54j4zzo 250 4 previously previously RB cord-258172-p54j4zzo 250 5 demonstrated demonstrate VBD cord-258172-p54j4zzo 250 6 that that IN cord-258172-p54j4zzo 250 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 250 8 mRNA mRNA NNP cord-258172-p54j4zzo 250 9 and and CC cord-258172-p54j4zzo 250 10 protein protein NN cord-258172-p54j4zzo 250 11 levels level NNS cord-258172-p54j4zzo 250 12 increased increase VBD cord-258172-p54j4zzo 250 13 during during IN cord-258172-p54j4zzo 250 14 the the DT cord-258172-p54j4zzo 250 15 early early JJ cord-258172-p54j4zzo 250 16 stages stage NNS cord-258172-p54j4zzo 250 17 of of IN cord-258172-p54j4zzo 250 18 hypoxia hypoxia NN cord-258172-p54j4zzo 250 19 and and CC cord-258172-p54j4zzo 250 20 decreased decrease VBD cord-258172-p54j4zzo 250 21 to to IN cord-258172-p54j4zzo 250 22 near near IN cord-258172-p54j4zzo 250 23 - - HYPH cord-258172-p54j4zzo 250 24 baseline baseline NN cord-258172-p54j4zzo 250 25 levels level NNS cord-258172-p54j4zzo 250 26 at at IN cord-258172-p54j4zzo 250 27 later later JJ cord-258172-p54j4zzo 250 28 stages stage NNS cord-258172-p54j4zzo 250 29 after after IN cord-258172-p54j4zzo 250 30 hypoxia hypoxia NN cord-258172-p54j4zzo 250 31 inducible inducible JJ cord-258172-p54j4zzo 250 32 factor factor NN cord-258172-p54j4zzo 250 33 ( ( -LRB- cord-258172-p54j4zzo 250 34 HIF)-1α hif)-1α NN cord-258172-p54j4zzo 250 35 accumulation accumulation NN cord-258172-p54j4zzo 250 36 [ [ -LRB- cord-258172-p54j4zzo 250 37 76 76 CD cord-258172-p54j4zzo 250 38 ] ] -RRB- cord-258172-p54j4zzo 250 39 . . . cord-258172-p54j4zzo 251 1 Based base VBN cord-258172-p54j4zzo 251 2 on on IN cord-258172-p54j4zzo 251 3 these these DT cord-258172-p54j4zzo 251 4 findings finding NNS cord-258172-p54j4zzo 251 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 251 6 has have VBZ cord-258172-p54j4zzo 251 7 been be VBN cord-258172-p54j4zzo 251 8 listed list VBN cord-258172-p54j4zzo 251 9 as as IN cord-258172-p54j4zzo 251 10 a a DT cord-258172-p54j4zzo 251 11 HIF1α HIF1α NNP cord-258172-p54j4zzo 251 12 - - HYPH cord-258172-p54j4zzo 251 13 target target NN cord-258172-p54j4zzo 251 14 gene gene NN cord-258172-p54j4zzo 251 15 [ [ -LRB- cord-258172-p54j4zzo 251 16 77 77 CD cord-258172-p54j4zzo 251 17 ] ] -RRB- cord-258172-p54j4zzo 251 18 , , , cord-258172-p54j4zzo 251 19 although although IN cord-258172-p54j4zzo 251 20 it -PRON- PRP cord-258172-p54j4zzo 251 21 does do VBZ cord-258172-p54j4zzo 251 22 not not RB cord-258172-p54j4zzo 251 23 follow follow VB cord-258172-p54j4zzo 251 24 the the DT cord-258172-p54j4zzo 251 25 typical typical JJ cord-258172-p54j4zzo 251 26 HIF1α HIF1α NNP cord-258172-p54j4zzo 251 27 regulated regulated JJ cord-258172-p54j4zzo 251 28 expression expression NN cord-258172-p54j4zzo 251 29 pattern pattern NN cord-258172-p54j4zzo 251 30 , , , cord-258172-p54j4zzo 251 31 nor nor CC cord-258172-p54j4zzo 251 32 is be VBZ cord-258172-p54j4zzo 251 33 there there EX cord-258172-p54j4zzo 251 34 any any DT cord-258172-p54j4zzo 251 35 predicted predict VBN cord-258172-p54j4zzo 251 36 HIF1α HIF1α NNP cord-258172-p54j4zzo 251 37 binding bind VBG cord-258172-p54j4zzo 251 38 site site NN cord-258172-p54j4zzo 251 39 in in IN cord-258172-p54j4zzo 251 40 our -PRON- PRP$ cord-258172-p54j4zzo 251 41 analyses analysis NNS cord-258172-p54j4zzo 251 42 . . . cord-258172-p54j4zzo 252 1 However however RB cord-258172-p54j4zzo 252 2 , , , cord-258172-p54j4zzo 252 3 HNF1B HNF1B NNP cord-258172-p54j4zzo 252 4 has have VBZ cord-258172-p54j4zzo 252 5 been be VBN cord-258172-p54j4zzo 252 6 identified identify VBN cord-258172-p54j4zzo 252 7 as as IN cord-258172-p54j4zzo 252 8 upregulated upregulate VBN cord-258172-p54j4zzo 252 9 in in IN cord-258172-p54j4zzo 252 10 hypoxia hypoxia NN cord-258172-p54j4zzo 252 11 in in IN cord-258172-p54j4zzo 252 12 kidney kidney NN cord-258172-p54j4zzo 252 13 , , , cord-258172-p54j4zzo 252 14 independent independent JJ cord-258172-p54j4zzo 252 15 of of IN cord-258172-p54j4zzo 252 16 HIF1α HIF1α NNP cord-258172-p54j4zzo 252 17 [ [ -LRB- cord-258172-p54j4zzo 252 18 78 78 CD cord-258172-p54j4zzo 252 19 ] ] -RRB- cord-258172-p54j4zzo 252 20 , , , cord-258172-p54j4zzo 252 21 and and CC cord-258172-p54j4zzo 252 22 in in IN cord-258172-p54j4zzo 252 23 hypoxic hypoxic JJ cord-258172-p54j4zzo 252 24 embryonic embryonic JJ cord-258172-p54j4zzo 252 25 stem stem NN cord-258172-p54j4zzo 252 26 cells cell NNS cord-258172-p54j4zzo 252 27 HIF1α HIF1α NNP cord-258172-p54j4zzo 252 28 has have VBZ cord-258172-p54j4zzo 252 29 been be VBN cord-258172-p54j4zzo 252 30 shown show VBN cord-258172-p54j4zzo 252 31 to to TO cord-258172-p54j4zzo 252 32 increase increase VB cord-258172-p54j4zzo 252 33 expression expression NN cord-258172-p54j4zzo 252 34 of of IN cord-258172-p54j4zzo 252 35 transcription transcription NN cord-258172-p54j4zzo 252 36 factors factor NNS cord-258172-p54j4zzo 253 1 TCF7 TCF7 NNP cord-258172-p54j4zzo 253 2 / / SYM cord-258172-p54j4zzo 253 3 LEF1 LEF1 NNP cord-258172-p54j4zzo 253 4 ( ( -LRB- cord-258172-p54j4zzo 253 5 predicted predict VBN cord-258172-p54j4zzo 253 6 to to TO cord-258172-p54j4zzo 253 7 bind bind VB cord-258172-p54j4zzo 253 8 the the DT cord-258172-p54j4zzo 253 9 promoter promoter NN cord-258172-p54j4zzo 253 10 of of IN cord-258172-p54j4zzo 253 11 the the DT cord-258172-p54j4zzo 253 12 lung lung NN cord-258172-p54j4zzo 253 13 - - HYPH cord-258172-p54j4zzo 253 14 specific specific JJ cord-258172-p54j4zzo 253 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 253 16 transcript transcript NN cord-258172-p54j4zzo 253 17 ) ) -RRB- cord-258172-p54j4zzo 253 18 through through IN cord-258172-p54j4zzo 253 19 Wnt Wnt NNP cord-258172-p54j4zzo 253 20 / / SYM cord-258172-p54j4zzo 253 21 β β NNP cord-258172-p54j4zzo 253 22 - - HYPH cord-258172-p54j4zzo 253 23 catenin catenin NNP cord-258172-p54j4zzo 253 24 signaling signal VBG cord-258172-p54j4zzo 253 25 [ [ -LRB- cord-258172-p54j4zzo 253 26 79 79 CD cord-258172-p54j4zzo 253 27 ] ] -RRB- cord-258172-p54j4zzo 253 28 . . . cord-258172-p54j4zzo 254 1 Recent recent JJ cord-258172-p54j4zzo 254 2 work work NN cord-258172-p54j4zzo 254 3 has have VBZ cord-258172-p54j4zzo 254 4 shown show VBN cord-258172-p54j4zzo 254 5 that that IN cord-258172-p54j4zzo 254 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 254 7 expression expression NN cord-258172-p54j4zzo 254 8 is be VBZ cord-258172-p54j4zzo 254 9 stimulated stimulate VBN cord-258172-p54j4zzo 254 10 by by IN cord-258172-p54j4zzo 254 11 interferon interferon NN cord-258172-p54j4zzo 254 12 alpha alpha NN cord-258172-p54j4zzo 254 13 ( ( -LRB- cord-258172-p54j4zzo 254 14 IFN IFN NNP cord-258172-p54j4zzo 254 15 - - HYPH cord-258172-p54j4zzo 254 16 α α NNP cord-258172-p54j4zzo 254 17 ) ) -RRB- cord-258172-p54j4zzo 254 18 in in IN cord-258172-p54j4zzo 254 19 vitro vitro FW cord-258172-p54j4zzo 254 20 and and CC cord-258172-p54j4zzo 254 21 computationally computationally RB cord-258172-p54j4zzo 254 22 identified identify VBN cord-258172-p54j4zzo 254 23 evidence evidence NN cord-258172-p54j4zzo 254 24 for for IN cord-258172-p54j4zzo 254 25 STAT1 stat1 NN cord-258172-p54j4zzo 254 26 , , , cord-258172-p54j4zzo 254 27 STAT3 STAT3 NNP cord-258172-p54j4zzo 254 28 , , , cord-258172-p54j4zzo 254 29 IRF8 IRF8 NNP cord-258172-p54j4zzo 254 30 , , , cord-258172-p54j4zzo 254 31 and and CC cord-258172-p54j4zzo 254 32 IRF1 IRF1 NNP cord-258172-p54j4zzo 254 33 TFBSs tfbs NNS cord-258172-p54j4zzo 254 34 in in IN cord-258172-p54j4zzo 254 35 the the DT cord-258172-p54j4zzo 254 36 ACE2 ACE2 NNP cord-258172-p54j4zzo 254 37 promoter promoter NN cord-258172-p54j4zzo 254 38 [ [ -LRB- cord-258172-p54j4zzo 254 39 80 80 CD cord-258172-p54j4zzo 254 40 ] ] -RRB- cord-258172-p54j4zzo 254 41 . . . cord-258172-p54j4zzo 255 1 Another another DT cord-258172-p54j4zzo 255 2 recent recent JJ cord-258172-p54j4zzo 255 3 study study NN cord-258172-p54j4zzo 255 4 has have VBZ cord-258172-p54j4zzo 255 5 identified identify VBN cord-258172-p54j4zzo 255 6 correlations correlation NNS cord-258172-p54j4zzo 255 7 of of IN cord-258172-p54j4zzo 255 8 expression expression NN cord-258172-p54j4zzo 255 9 between between IN cord-258172-p54j4zzo 255 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 255 11 and and CC cord-258172-p54j4zzo 255 12 other other JJ cord-258172-p54j4zzo 255 13 interferon interferon NN cord-258172-p54j4zzo 255 14 stimulated stimulate VBD cord-258172-p54j4zzo 255 15 genes gene NNS cord-258172-p54j4zzo 255 16 [ [ -LRB- cord-258172-p54j4zzo 255 17 81 81 CD cord-258172-p54j4zzo 255 18 ] ] -RRB- cord-258172-p54j4zzo 255 19 . . . cord-258172-p54j4zzo 256 1 Our -PRON- PRP$ cord-258172-p54j4zzo 256 2 analysis analysis NN cord-258172-p54j4zzo 256 3 produced produce VBD cord-258172-p54j4zzo 256 4 several several JJ cord-258172-p54j4zzo 256 5 putative putative JJ cord-258172-p54j4zzo 256 6 binding binding JJ cord-258172-p54j4zzo 256 7 sites site NNS cord-258172-p54j4zzo 256 8 for for IN cord-258172-p54j4zzo 256 9 interferon interferon NN cord-258172-p54j4zzo 256 10 - - HYPH cord-258172-p54j4zzo 256 11 stimulation stimulation NN cord-258172-p54j4zzo 256 12 mediating mediate VBG cord-258172-p54j4zzo 256 13 TF TF NNP cord-258172-p54j4zzo 256 14 genes gene NNS cord-258172-p54j4zzo 256 15 , , , cord-258172-p54j4zzo 256 16 proximal proximal JJ cord-258172-p54j4zzo 256 17 to to IN cord-258172-p54j4zzo 256 18 the the DT cord-258172-p54j4zzo 256 19 TSSs tss NNS cord-258172-p54j4zzo 256 20 of of IN cord-258172-p54j4zzo 256 21 the the DT cord-258172-p54j4zzo 256 22 intestine intestine NN cord-258172-p54j4zzo 256 23 - - HYPH cord-258172-p54j4zzo 256 24 specific specific JJ cord-258172-p54j4zzo 256 25 ( ( -LRB- cord-258172-p54j4zzo 256 26 STAT1 stat1 XX cord-258172-p54j4zzo 256 27 , , , cord-258172-p54j4zzo 256 28 IRF8 IRF8 NNP cord-258172-p54j4zzo 256 29 , , , cord-258172-p54j4zzo 256 30 and and CC cord-258172-p54j4zzo 256 31 IRF9 IRF9 NNP cord-258172-p54j4zzo 256 32 ) ) -RRB- cord-258172-p54j4zzo 257 1 and and CC cord-258172-p54j4zzo 257 2 lung lung NN cord-258172-p54j4zzo 257 3 - - HYPH cord-258172-p54j4zzo 257 4 specific specific JJ cord-258172-p54j4zzo 257 5 transcript transcript NN cord-258172-p54j4zzo 257 6 ( ( -LRB- cord-258172-p54j4zzo 257 7 IRF8 IRF8 NNP cord-258172-p54j4zzo 257 8 ) ) -RRB- cord-258172-p54j4zzo 257 9 . . . cord-258172-p54j4zzo 258 1 The the DT cord-258172-p54j4zzo 258 2 findings finding NNS cord-258172-p54j4zzo 258 3 of of IN cord-258172-p54j4zzo 258 4 these these DT cord-258172-p54j4zzo 258 5 studies study NNS cord-258172-p54j4zzo 258 6 , , , cord-258172-p54j4zzo 258 7 and and CC cord-258172-p54j4zzo 258 8 our -PRON- PRP$ cord-258172-p54j4zzo 258 9 own own JJ cord-258172-p54j4zzo 258 10 , , , cord-258172-p54j4zzo 258 11 potentially potentially RB cord-258172-p54j4zzo 258 12 reveal reveal VB cord-258172-p54j4zzo 258 13 a a DT cord-258172-p54j4zzo 258 14 scenario scenario NN cord-258172-p54j4zzo 258 15 where where WRB cord-258172-p54j4zzo 258 16 SARS SARS NNP cord-258172-p54j4zzo 258 17 - - HYPH cord-258172-p54j4zzo 258 18 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 258 19 infection infection NN cord-258172-p54j4zzo 258 20 itself -PRON- PRP cord-258172-p54j4zzo 258 21 may may MD cord-258172-p54j4zzo 258 22 induce induce VB cord-258172-p54j4zzo 258 23 expression expression NN cord-258172-p54j4zzo 258 24 of of IN cord-258172-p54j4zzo 258 25 ACE2 ACE2 NNP cord-258172-p54j4zzo 258 26 and and CC cord-258172-p54j4zzo 258 27 thus thus RB cord-258172-p54j4zzo 258 28 provide provide VB cord-258172-p54j4zzo 258 29 a a DT cord-258172-p54j4zzo 258 30 self self NN cord-258172-p54j4zzo 258 31 - - HYPH cord-258172-p54j4zzo 258 32 perpetuating perpetuate VBG cord-258172-p54j4zzo 258 33 route route NN cord-258172-p54j4zzo 258 34 of of IN cord-258172-p54j4zzo 258 35 increased increase VBN cord-258172-p54j4zzo 258 36 cellular cellular JJ cord-258172-p54j4zzo 258 37 infection infection NN cord-258172-p54j4zzo 258 38 . . . cord-258172-p54j4zzo 259 1 This this DT cord-258172-p54j4zzo 259 2 could could MD cord-258172-p54j4zzo 259 3 explain explain VB cord-258172-p54j4zzo 259 4 how how WRB cord-258172-p54j4zzo 259 5 such such JJ cord-258172-p54j4zzo 259 6 low low JJ cord-258172-p54j4zzo 259 7 overall overall JJ cord-258172-p54j4zzo 259 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 259 9 expression expression NN cord-258172-p54j4zzo 259 10 in in IN cord-258172-p54j4zzo 259 11 normal normal JJ cord-258172-p54j4zzo 259 12 lungs lung NNS cord-258172-p54j4zzo 259 13 translates translate VBZ cord-258172-p54j4zzo 259 14 into into IN cord-258172-p54j4zzo 259 15 a a DT cord-258172-p54j4zzo 259 16 fatal fatal JJ cord-258172-p54j4zzo 259 17 disease disease NN cord-258172-p54j4zzo 259 18 state state NN cord-258172-p54j4zzo 259 19 . . . cord-258172-p54j4zzo 260 1 However however RB cord-258172-p54j4zzo 260 2 , , , cord-258172-p54j4zzo 260 3 a a DT cord-258172-p54j4zzo 260 4 series series NN cord-258172-p54j4zzo 260 5 of of IN cord-258172-p54j4zzo 260 6 recent recent JJ cord-258172-p54j4zzo 260 7 pre pre JJ cord-258172-p54j4zzo 260 8 - - JJ cord-258172-p54j4zzo 260 9 print print JJ cord-258172-p54j4zzo 260 10 articles article NNS cord-258172-p54j4zzo 260 11 have have VBP cord-258172-p54j4zzo 260 12 identified identify VBN cord-258172-p54j4zzo 260 13 a a DT cord-258172-p54j4zzo 260 14 previously previously RB cord-258172-p54j4zzo 260 15 unreported unreported JJ cord-258172-p54j4zzo 260 16 novel novel NN cord-258172-p54j4zzo 260 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 260 18 transcript transcript NN cord-258172-p54j4zzo 260 19 with with IN cord-258172-p54j4zzo 260 20 a a DT cord-258172-p54j4zzo 260 21 transcription transcription NN cord-258172-p54j4zzo 260 22 start start NN cord-258172-p54j4zzo 260 23 site site NN cord-258172-p54j4zzo 260 24 occurring occur VBG cord-258172-p54j4zzo 260 25 between between IN cord-258172-p54j4zzo 260 26 exons exon NNS cord-258172-p54j4zzo 260 27 9 9 CD cord-258172-p54j4zzo 260 28 and and CC cord-258172-p54j4zzo 260 29 10 10 CD cord-258172-p54j4zzo 260 30 of of IN cord-258172-p54j4zzo 260 31 the the DT cord-258172-p54j4zzo 260 32 canonical canonical JJ cord-258172-p54j4zzo 260 33 ACE2 ACE2 NNP cord-258172-p54j4zzo 260 34 gene gene NN cord-258172-p54j4zzo 260 35 . . . cord-258172-p54j4zzo 261 1 Alternatively alternatively RB cord-258172-p54j4zzo 261 2 , , , cord-258172-p54j4zzo 261 3 this this DT cord-258172-p54j4zzo 261 4 truncated truncated JJ cord-258172-p54j4zzo 261 5 transcript transcript NN cord-258172-p54j4zzo 261 6 has have VBZ cord-258172-p54j4zzo 261 7 been be VBN cord-258172-p54j4zzo 261 8 named name VBN cord-258172-p54j4zzo 261 9 LTR16A1-ACE2 LTR16A1-ACE2 NNP cord-258172-p54j4zzo 261 10 [ [ -LRB- cord-258172-p54j4zzo 261 11 56 56 CD cord-258172-p54j4zzo 261 12 ] ] -RRB- cord-258172-p54j4zzo 262 1 , , , cord-258172-p54j4zzo 262 2 delta delta NNP cord-258172-p54j4zzo 262 3 - - : cord-258172-p54j4zzo 262 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 262 5 [ [ -LRB- cord-258172-p54j4zzo 262 6 57 57 CD cord-258172-p54j4zzo 262 7 ] ] -RRB- cord-258172-p54j4zzo 262 8 , , , cord-258172-p54j4zzo 262 9 or or CC cord-258172-p54j4zzo 262 10 simply simply RB cord-258172-p54j4zzo 262 11 ' ' `` cord-258172-p54j4zzo 262 12 short short JJ cord-258172-p54j4zzo 262 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 262 14 ' ' POS cord-258172-p54j4zzo 262 15 [ [ -LRB- cord-258172-p54j4zzo 262 16 58 58 CD cord-258172-p54j4zzo 262 17 ] ] -RRB- cord-258172-p54j4zzo 262 18 . . . cord-258172-p54j4zzo 263 1 In in IN cord-258172-p54j4zzo 263 2 all all DT cord-258172-p54j4zzo 263 3 cases case NNS cord-258172-p54j4zzo 263 4 the the DT cord-258172-p54j4zzo 263 5 authors author NNS cord-258172-p54j4zzo 263 6 have have VBP cord-258172-p54j4zzo 263 7 concluded conclude VBN cord-258172-p54j4zzo 263 8 that that IN cord-258172-p54j4zzo 263 9 this this DT cord-258172-p54j4zzo 263 10 new new JJ cord-258172-p54j4zzo 263 11 transcript transcript NN cord-258172-p54j4zzo 263 12 is be VBZ cord-258172-p54j4zzo 263 13 more more RBR cord-258172-p54j4zzo 263 14 strongly strongly RB cord-258172-p54j4zzo 263 15 stimulated stimulate VBN cord-258172-p54j4zzo 263 16 by by IN cord-258172-p54j4zzo 263 17 interferon interferon NN cord-258172-p54j4zzo 263 18 , , , cord-258172-p54j4zzo 263 19 though though IN cord-258172-p54j4zzo 263 20 their -PRON- PRP$ cord-258172-p54j4zzo 263 21 results result NNS cord-258172-p54j4zzo 263 22 differ differ VBP cord-258172-p54j4zzo 263 23 on on IN cord-258172-p54j4zzo 263 24 whether whether IN cord-258172-p54j4zzo 263 25 transcription transcription NN cord-258172-p54j4zzo 263 26 of of IN cord-258172-p54j4zzo 263 27 the the DT cord-258172-p54j4zzo 263 28 long long JJ cord-258172-p54j4zzo 263 29 form form NN cord-258172-p54j4zzo 263 30 is be VBZ cord-258172-p54j4zzo 263 31 [ [ -LRB- cord-258172-p54j4zzo 263 32 58 58 CD cord-258172-p54j4zzo 263 33 ] ] -RRB- cord-258172-p54j4zzo 263 34 or or CC cord-258172-p54j4zzo 263 35 is be VBZ cord-258172-p54j4zzo 263 36 not not RB cord-258172-p54j4zzo 263 37 [ [ -LRB- cord-258172-p54j4zzo 263 38 56 56 CD cord-258172-p54j4zzo 263 39 , , , cord-258172-p54j4zzo 263 40 57 57 CD cord-258172-p54j4zzo 263 41 ] ] -RRB- cord-258172-p54j4zzo 264 1 interferon interferon NN cord-258172-p54j4zzo 264 2 - - HYPH cord-258172-p54j4zzo 264 3 related relate VBN cord-258172-p54j4zzo 264 4 . . . cord-258172-p54j4zzo 265 1 Importantly importantly RB cord-258172-p54j4zzo 265 2 , , , cord-258172-p54j4zzo 265 3 a a DT cord-258172-p54j4zzo 265 4 protein protein NN cord-258172-p54j4zzo 265 5 resulting result VBG cord-258172-p54j4zzo 265 6 from from IN cord-258172-p54j4zzo 265 7 this this DT cord-258172-p54j4zzo 265 8 transcript transcript NN cord-258172-p54j4zzo 265 9 would would MD cord-258172-p54j4zzo 265 10 lack lack VB cord-258172-p54j4zzo 265 11 the the DT cord-258172-p54j4zzo 265 12 356 356 CD cord-258172-p54j4zzo 265 13 amino amino JJ cord-258172-p54j4zzo 265 14 acids acid NNS cord-258172-p54j4zzo 265 15 of of IN cord-258172-p54j4zzo 265 16 the the DT cord-258172-p54j4zzo 265 17 first first JJ cord-258172-p54j4zzo 265 18 9 9 CD cord-258172-p54j4zzo 265 19 exons exon NNS cord-258172-p54j4zzo 265 20 , , , cord-258172-p54j4zzo 265 21 and and CC cord-258172-p54j4zzo 265 22 thus thus RB cord-258172-p54j4zzo 265 23 not not RB cord-258172-p54j4zzo 265 24 contain contain VB cord-258172-p54j4zzo 265 25 the the DT cord-258172-p54j4zzo 265 26 known know VBN cord-258172-p54j4zzo 265 27 SARS SARS NNP cord-258172-p54j4zzo 265 28 - - HYPH cord-258172-p54j4zzo 265 29 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 265 30 binding binding NN cord-258172-p54j4zzo 265 31 domains domain NNS cord-258172-p54j4zzo 265 32 , , , cord-258172-p54j4zzo 265 33 and and CC cord-258172-p54j4zzo 265 34 all all DT cord-258172-p54j4zzo 265 35 three three CD cord-258172-p54j4zzo 265 36 studies study NNS cord-258172-p54j4zzo 265 37 have have VBP cord-258172-p54j4zzo 265 38 hypothesized hypothesize VBN cord-258172-p54j4zzo 265 39 that that IN cord-258172-p54j4zzo 265 40 the the DT cord-258172-p54j4zzo 265 41 short short JJ cord-258172-p54j4zzo 265 42 form form NN cord-258172-p54j4zzo 265 43 ACE2 ACE2 NNP cord-258172-p54j4zzo 265 44 would would MD cord-258172-p54j4zzo 265 45 not not RB cord-258172-p54j4zzo 265 46 likely likely RB cord-258172-p54j4zzo 265 47 be be VB cord-258172-p54j4zzo 265 48 a a DT cord-258172-p54j4zzo 265 49 point point NN cord-258172-p54j4zzo 265 50 of of IN cord-258172-p54j4zzo 265 51 viral viral JJ cord-258172-p54j4zzo 265 52 entry entry NN cord-258172-p54j4zzo 265 53 . . . cord-258172-p54j4zzo 266 1 One one CD cord-258172-p54j4zzo 266 2 study study NN cord-258172-p54j4zzo 266 3 was be VBD cord-258172-p54j4zzo 266 4 unsuccessful unsuccessful JJ cord-258172-p54j4zzo 266 5 in in IN cord-258172-p54j4zzo 266 6 attempting attempt VBG cord-258172-p54j4zzo 266 7 to to TO cord-258172-p54j4zzo 266 8 produce produce VB cord-258172-p54j4zzo 266 9 a a DT cord-258172-p54j4zzo 266 10 viable viable JJ cord-258172-p54j4zzo 266 11 protein protein NN cord-258172-p54j4zzo 266 12 from from IN cord-258172-p54j4zzo 266 13 the the DT cord-258172-p54j4zzo 266 14 short short JJ cord-258172-p54j4zzo 266 15 transcript transcript NN cord-258172-p54j4zzo 266 16 [ [ -LRB- cord-258172-p54j4zzo 266 17 56 56 CD cord-258172-p54j4zzo 266 18 ] ] -RRB- cord-258172-p54j4zzo 266 19 , , , cord-258172-p54j4zzo 266 20 while while IN cord-258172-p54j4zzo 266 21 others other NNS cord-258172-p54j4zzo 266 22 [ [ -LRB- cord-258172-p54j4zzo 266 23 57 57 CD cord-258172-p54j4zzo 266 24 , , , cord-258172-p54j4zzo 266 25 58 58 CD cord-258172-p54j4zzo 266 26 ] ] -RRB- cord-258172-p54j4zzo 266 27 identified identify VBN cord-258172-p54j4zzo 266 28 peptides peptide NNS cord-258172-p54j4zzo 266 29 indicative indicative JJ cord-258172-p54j4zzo 266 30 of of IN cord-258172-p54j4zzo 266 31 the the DT cord-258172-p54j4zzo 266 32 short short JJ cord-258172-p54j4zzo 266 33 ACE2 ACE2 NNP cord-258172-p54j4zzo 266 34 protein protein NN cord-258172-p54j4zzo 266 35 in in IN cord-258172-p54j4zzo 266 36 data datum NNS cord-258172-p54j4zzo 266 37 from from IN cord-258172-p54j4zzo 266 38 mass mass JJ cord-258172-p54j4zzo 266 39 - - HYPH cord-258172-p54j4zzo 266 40 spec spec NN cord-258172-p54j4zzo 266 41 analysis analysis NN cord-258172-p54j4zzo 266 42 of of IN cord-258172-p54j4zzo 266 43 cancer cancer NN cord-258172-p54j4zzo 266 44 samples sample NNS cord-258172-p54j4zzo 266 45 ( ( -LRB- cord-258172-p54j4zzo 266 46 ovary ovary NN cord-258172-p54j4zzo 266 47 , , , cord-258172-p54j4zzo 266 48 colon colon NN cord-258172-p54j4zzo 266 49 , , , cord-258172-p54j4zzo 266 50 breast breast NN cord-258172-p54j4zzo 266 51 ) ) -RRB- cord-258172-p54j4zzo 266 52 from from IN cord-258172-p54j4zzo 266 53 The the DT cord-258172-p54j4zzo 266 54 Cancer Cancer NNP cord-258172-p54j4zzo 266 55 Genome Genome NNP cord-258172-p54j4zzo 266 56 Atlas Atlas NNP cord-258172-p54j4zzo 266 57 ( ( -LRB- cord-258172-p54j4zzo 266 58 TCGA TCGA NNP cord-258172-p54j4zzo 266 59 ) ) -RRB- cord-258172-p54j4zzo 266 60 . . . cord-258172-p54j4zzo 267 1 In in IN cord-258172-p54j4zzo 267 2 addition addition NN cord-258172-p54j4zzo 267 3 , , , cord-258172-p54j4zzo 267 4 Blume Blume NNP cord-258172-p54j4zzo 267 5 and and CC cord-258172-p54j4zzo 267 6 coworkers coworker NNS cord-258172-p54j4zzo 267 7 were be VBD cord-258172-p54j4zzo 267 8 able able JJ cord-258172-p54j4zzo 267 9 to to TO cord-258172-p54j4zzo 267 10 use use VB cord-258172-p54j4zzo 267 11 Western western JJ cord-258172-p54j4zzo 267 12 blotting blotting NN cord-258172-p54j4zzo 267 13 of of IN cord-258172-p54j4zzo 267 14 an an DT cord-258172-p54j4zzo 267 15 ACE2 ACE2 NNP cord-258172-p54j4zzo 267 16 antibody antibody NN cord-258172-p54j4zzo 267 17 targeting target VBG cord-258172-p54j4zzo 267 18 the the DT cord-258172-p54j4zzo 267 19 C C NNP cord-258172-p54j4zzo 267 20 - - HYPH cord-258172-p54j4zzo 267 21 terminal terminal NN cord-258172-p54j4zzo 267 22 domain domain NN cord-258172-p54j4zzo 267 23 to to TO cord-258172-p54j4zzo 267 24 identify identify VB cord-258172-p54j4zzo 267 25 appropriately appropriately RB cord-258172-p54j4zzo 267 26 sized sized JJ cord-258172-p54j4zzo 267 27 bands band NNS cord-258172-p54j4zzo 267 28 ( ( -LRB- cord-258172-p54j4zzo 267 29 ~50kDa ~50kDa NNP cord-258172-p54j4zzo 267 30 ) ) -RRB- cord-258172-p54j4zzo 267 31 , , , cord-258172-p54j4zzo 267 32 expected expect VBN cord-258172-p54j4zzo 267 33 of of IN cord-258172-p54j4zzo 267 34 the the DT cord-258172-p54j4zzo 267 35 short short JJ cord-258172-p54j4zzo 267 36 form form NN cord-258172-p54j4zzo 267 37 , , , cord-258172-p54j4zzo 267 38 in in IN cord-258172-p54j4zzo 267 39 nasal nasal JJ cord-258172-p54j4zzo 267 40 epithelial epithelial JJ cord-258172-p54j4zzo 267 41 cells cell NNS cord-258172-p54j4zzo 267 42 and and CC cord-258172-p54j4zzo 267 43 bronchial bronchial JJ cord-258172-p54j4zzo 267 44 epithelial epithelial JJ cord-258172-p54j4zzo 267 45 cells cell NNS cord-258172-p54j4zzo 267 46 [ [ -LRB- cord-258172-p54j4zzo 267 47 58 58 CD cord-258172-p54j4zzo 267 48 ] ] -RRB- cord-258172-p54j4zzo 267 49 . . . cord-258172-p54j4zzo 268 1 All all DT cord-258172-p54j4zzo 268 2 three three CD cord-258172-p54j4zzo 268 3 studies study NNS cord-258172-p54j4zzo 268 4 found find VBD cord-258172-p54j4zzo 268 5 that that IN cord-258172-p54j4zzo 268 6 the the DT cord-258172-p54j4zzo 268 7 ratio ratio NN cord-258172-p54j4zzo 268 8 of of IN cord-258172-p54j4zzo 268 9 expression expression NN cord-258172-p54j4zzo 268 10 of of IN cord-258172-p54j4zzo 268 11 the the DT cord-258172-p54j4zzo 268 12 short short JJ cord-258172-p54j4zzo 268 13 form form NN cord-258172-p54j4zzo 268 14 to to IN cord-258172-p54j4zzo 268 15 long long JJ cord-258172-p54j4zzo 268 16 form form NN cord-258172-p54j4zzo 268 17 is be VBZ cord-258172-p54j4zzo 268 18 highest high JJS cord-258172-p54j4zzo 268 19 in in IN cord-258172-p54j4zzo 268 20 nose nose NN cord-258172-p54j4zzo 268 21 and and CC cord-258172-p54j4zzo 268 22 mouth mouth NN cord-258172-p54j4zzo 268 23 and and CC cord-258172-p54j4zzo 268 24 reduces reduce VBZ cord-258172-p54j4zzo 268 25 as as IN cord-258172-p54j4zzo 268 26 you -PRON- PRP cord-258172-p54j4zzo 268 27 progress progress VBP cord-258172-p54j4zzo 268 28 down down IN cord-258172-p54j4zzo 268 29 the the DT cord-258172-p54j4zzo 268 30 airways airway NNS cord-258172-p54j4zzo 268 31 and and CC cord-258172-p54j4zzo 268 32 digestive digestive JJ cord-258172-p54j4zzo 268 33 tracts tract NNS cord-258172-p54j4zzo 268 34 . . . cord-258172-p54j4zzo 269 1 Ng Ng NNP cord-258172-p54j4zzo 269 2 et et FW cord-258172-p54j4zzo 269 3 al al NNP cord-258172-p54j4zzo 269 4 . . . cord-258172-p54j4zzo 270 1 in in IN cord-258172-p54j4zzo 270 2 [ [ -LRB- cord-258172-p54j4zzo 270 3 56 56 CD cord-258172-p54j4zzo 270 4 ] ] -RRB- cord-258172-p54j4zzo 270 5 have have VBP cord-258172-p54j4zzo 270 6 identified identify VBN cord-258172-p54j4zzo 270 7 a a DT cord-258172-p54j4zzo 270 8 long long JJ cord-258172-p54j4zzo 270 9 terminal terminal NN cord-258172-p54j4zzo 270 10 repeat repeat NN cord-258172-p54j4zzo 270 11 ( ( -LRB- cord-258172-p54j4zzo 270 12 LTR ltr NN cord-258172-p54j4zzo 270 13 ) ) -RRB- cord-258172-p54j4zzo 270 14 ( ( -LRB- cord-258172-p54j4zzo 270 15 LTR16A1 ltr16a1 NN cord-258172-p54j4zzo 270 16 ) ) -RRB- cord-258172-p54j4zzo 270 17 occurring occur VBG cord-258172-p54j4zzo 270 18 in in IN cord-258172-p54j4zzo 270 19 intron intron NN cord-258172-p54j4zzo 270 20 9 9 CD cord-258172-p54j4zzo 270 21 of of IN cord-258172-p54j4zzo 270 22 ACE2 ACE2 NNP cord-258172-p54j4zzo 270 23 , , , cord-258172-p54j4zzo 270 24 comprising comprise VBG cord-258172-p54j4zzo 270 25 most most JJS cord-258172-p54j4zzo 270 26 of of IN cord-258172-p54j4zzo 270 27 the the DT cord-258172-p54j4zzo 270 28 first first JJ cord-258172-p54j4zzo 270 29 exon exon NN cord-258172-p54j4zzo 270 30 of of IN cord-258172-p54j4zzo 270 31 short short JJ cord-258172-p54j4zzo 270 32 - - HYPH cord-258172-p54j4zzo 270 33 form form NN cord-258172-p54j4zzo 270 34 ACE2 ACE2 NNP cord-258172-p54j4zzo 270 35 , , , cord-258172-p54j4zzo 270 36 which which WDT cord-258172-p54j4zzo 270 37 they -PRON- PRP cord-258172-p54j4zzo 270 38 posit posit VBP cord-258172-p54j4zzo 270 39 may may MD cord-258172-p54j4zzo 270 40 be be VB cord-258172-p54j4zzo 270 41 related relate VBN cord-258172-p54j4zzo 270 42 to to IN cord-258172-p54j4zzo 270 43 the the DT cord-258172-p54j4zzo 270 44 observed observed JJ cord-258172-p54j4zzo 270 45 interferon interferon NN cord-258172-p54j4zzo 270 46 reactivity reactivity NN cord-258172-p54j4zzo 270 47 . . . cord-258172-p54j4zzo 271 1 Our -PRON- PRP$ cord-258172-p54j4zzo 271 2 TFBS TFBS NNP cord-258172-p54j4zzo 271 3 analysis analysis NN cord-258172-p54j4zzo 271 4 of of IN cord-258172-p54j4zzo 271 5 LTR16A1 ltr16a1 NN cord-258172-p54j4zzo 271 6 and and CC cord-258172-p54j4zzo 271 7 the the DT cord-258172-p54j4zzo 271 8 promoter promoter NN cord-258172-p54j4zzo 271 9 of of IN cord-258172-p54j4zzo 271 10 the the DT cord-258172-p54j4zzo 271 11 short short JJ cord-258172-p54j4zzo 271 12 ACE2 ACE2 NNP cord-258172-p54j4zzo 271 13 transcript transcript NN cord-258172-p54j4zzo 271 14 revealed reveal VBD cord-258172-p54j4zzo 271 15 putative putative JJ cord-258172-p54j4zzo 271 16 binding binding NN cord-258172-p54j4zzo 271 17 sites site NNS cord-258172-p54j4zzo 271 18 for for IN cord-258172-p54j4zzo 271 19 multiple multiple JJ cord-258172-p54j4zzo 271 20 IRF IRF NNP cord-258172-p54j4zzo 271 21 proteins protein NNS cord-258172-p54j4zzo 271 22 and and CC cord-258172-p54j4zzo 271 23 a a DT cord-258172-p54j4zzo 271 24 STAT1 stat1 NN cord-258172-p54j4zzo 271 25 : : : cord-258172-p54j4zzo 272 1 STAT2 STAT2 NNS cord-258172-p54j4zzo 272 2 dimer dimer NNP cord-258172-p54j4zzo 272 3 immediately immediately RB cord-258172-p54j4zzo 272 4 upstream upstream RB cord-258172-p54j4zzo 272 5 ( ( -LRB- cord-258172-p54j4zzo 272 6 < < XX cord-258172-p54j4zzo 272 7 50 50 CD cord-258172-p54j4zzo 272 8 bp bp NNP cord-258172-p54j4zzo 272 9 ) ) -RRB- cord-258172-p54j4zzo 272 10 of of IN cord-258172-p54j4zzo 272 11 the the DT cord-258172-p54j4zzo 272 12 newfound newfound NN cord-258172-p54j4zzo 272 13 TSS tss NN cord-258172-p54j4zzo 272 14 and and CC cord-258172-p54j4zzo 272 15 LTR16A1 LTR16A1 NNP cord-258172-p54j4zzo 272 16 ( ( -LRB- cord-258172-p54j4zzo 272 17 Fig Fig NNP cord-258172-p54j4zzo 272 18 9 9 CD cord-258172-p54j4zzo 272 19 ) ) -RRB- cord-258172-p54j4zzo 272 20 , , , cord-258172-p54j4zzo 272 21 and and CC cord-258172-p54j4zzo 272 22 STAT stat NN cord-258172-p54j4zzo 272 23 protein protein NN cord-258172-p54j4zzo 272 24 binding bind VBG cord-258172-p54j4zzo 272 25 sites site NNS cord-258172-p54j4zzo 272 26 further further RB cord-258172-p54j4zzo 272 27 upstream upstream RB cord-258172-p54j4zzo 272 28 . . . cord-258172-p54j4zzo 273 1 While while IN cord-258172-p54j4zzo 273 2 all all DT cord-258172-p54j4zzo 273 3 three three CD cord-258172-p54j4zzo 273 4 studies study NNS cord-258172-p54j4zzo 273 5 promote promote VBP cord-258172-p54j4zzo 273 6 this this DT cord-258172-p54j4zzo 273 7 new new JJ cord-258172-p54j4zzo 273 8 short short JJ cord-258172-p54j4zzo 273 9 form form NN cord-258172-p54j4zzo 273 10 of of IN cord-258172-p54j4zzo 273 11 ACE2 ACE2 NNP cord-258172-p54j4zzo 273 12 as as IN cord-258172-p54j4zzo 273 13 more more RBR cord-258172-p54j4zzo 273 14 strongly strongly RB cord-258172-p54j4zzo 273 15 upregulated upregulate VBN cord-258172-p54j4zzo 273 16 by by IN cord-258172-p54j4zzo 273 17 interferon interferon NN cord-258172-p54j4zzo 273 18 , , , cord-258172-p54j4zzo 273 19 two two CD cord-258172-p54j4zzo 273 20 [ [ -LRB- cord-258172-p54j4zzo 273 21 57 57 CD cord-258172-p54j4zzo 273 22 , , , cord-258172-p54j4zzo 273 23 58 58 CD cord-258172-p54j4zzo 273 24 ] ] -RRB- cord-258172-p54j4zzo 273 25 also also RB cord-258172-p54j4zzo 273 26 contain contain VBP cord-258172-p54j4zzo 273 27 results result NNS cord-258172-p54j4zzo 273 28 that that WDT cord-258172-p54j4zzo 273 29 show show VBP cord-258172-p54j4zzo 273 30 that that IN cord-258172-p54j4zzo 273 31 long long JJ cord-258172-p54j4zzo 273 32 form form NN cord-258172-p54j4zzo 273 33 ACE2 ACE2 NNP cord-258172-p54j4zzo 273 34 is be VBZ cord-258172-p54j4zzo 273 35 itself -PRON- PRP cord-258172-p54j4zzo 273 36 also also RB cord-258172-p54j4zzo 273 37 upregulated upregulate VBN cord-258172-p54j4zzo 273 38 , , , cord-258172-p54j4zzo 273 39 to to IN cord-258172-p54j4zzo 273 40 a a DT cord-258172-p54j4zzo 273 41 lesser less JJR cord-258172-p54j4zzo 273 42 extent extent NN cord-258172-p54j4zzo 273 43 , , , cord-258172-p54j4zzo 273 44 in in IN cord-258172-p54j4zzo 273 45 presence presence NN cord-258172-p54j4zzo 273 46 of of IN cord-258172-p54j4zzo 273 47 interferon interferon NN cord-258172-p54j4zzo 273 48 or or CC cord-258172-p54j4zzo 273 49 infection infection NN cord-258172-p54j4zzo 273 50 . . . cord-258172-p54j4zzo 274 1 These these DT cord-258172-p54j4zzo 274 2 three three CD cord-258172-p54j4zzo 274 3 manuscripts manuscript NNS cord-258172-p54j4zzo 274 4 represent represent VBP cord-258172-p54j4zzo 274 5 the the DT cord-258172-p54j4zzo 274 6 leading leading JJ cord-258172-p54j4zzo 274 7 edge edge NN cord-258172-p54j4zzo 274 8 of of IN cord-258172-p54j4zzo 274 9 , , , cord-258172-p54j4zzo 274 10 and and CC cord-258172-p54j4zzo 274 11 first first JJ cord-258172-p54j4zzo 274 12 forays foray NNS cord-258172-p54j4zzo 274 13 into into IN cord-258172-p54j4zzo 274 14 , , , cord-258172-p54j4zzo 274 15 our -PRON- PRP$ cord-258172-p54j4zzo 274 16 understanding understanding NN cord-258172-p54j4zzo 274 17 of of IN cord-258172-p54j4zzo 274 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 274 19 expression expression NN cord-258172-p54j4zzo 274 20 in in IN cord-258172-p54j4zzo 274 21 response response NN cord-258172-p54j4zzo 274 22 to to IN cord-258172-p54j4zzo 274 23 interferon interferon NN cord-258172-p54j4zzo 274 24 . . . cord-258172-p54j4zzo 275 1 Accordingly accordingly RB cord-258172-p54j4zzo 275 2 , , , cord-258172-p54j4zzo 275 3 while while IN cord-258172-p54j4zzo 275 4 there there EX cord-258172-p54j4zzo 275 5 are be VBP cord-258172-p54j4zzo 275 6 broad broad JJ cord-258172-p54j4zzo 275 7 strokes stroke NNS cord-258172-p54j4zzo 275 8 of of IN cord-258172-p54j4zzo 275 9 agreement agreement NN cord-258172-p54j4zzo 275 10 , , , cord-258172-p54j4zzo 275 11 there there EX cord-258172-p54j4zzo 275 12 is be VBZ cord-258172-p54j4zzo 275 13 not not RB cord-258172-p54j4zzo 275 14 consensus consensus NN cord-258172-p54j4zzo 275 15 on on IN cord-258172-p54j4zzo 275 16 all all DT cord-258172-p54j4zzo 275 17 points point NNS cord-258172-p54j4zzo 275 18 . . . cord-258172-p54j4zzo 276 1 Peer peer NN cord-258172-p54j4zzo 276 2 - - HYPH cord-258172-p54j4zzo 276 3 review review NN cord-258172-p54j4zzo 276 4 of of IN cord-258172-p54j4zzo 276 5 the the DT cord-258172-p54j4zzo 276 6 results result NNS cord-258172-p54j4zzo 276 7 needs need VBZ cord-258172-p54j4zzo 276 8 to to TO cord-258172-p54j4zzo 276 9 be be VB cord-258172-p54j4zzo 276 10 first first RB cord-258172-p54j4zzo 276 11 performed perform VBN cord-258172-p54j4zzo 276 12 , , , cord-258172-p54j4zzo 276 13 and and CC cord-258172-p54j4zzo 276 14 subsequent subsequent JJ cord-258172-p54j4zzo 276 15 study study NN cord-258172-p54j4zzo 276 16 is be VBZ cord-258172-p54j4zzo 276 17 needed need VBN cord-258172-p54j4zzo 276 18 to to TO cord-258172-p54j4zzo 276 19 validate validate VB cord-258172-p54j4zzo 276 20 and and CC cord-258172-p54j4zzo 276 21 expand expand VB cord-258172-p54j4zzo 276 22 these these DT cord-258172-p54j4zzo 276 23 new new JJ cord-258172-p54j4zzo 276 24 findings finding NNS cord-258172-p54j4zzo 276 25 . . . cord-258172-p54j4zzo 277 1 In in IN cord-258172-p54j4zzo 277 2 summary summary NN cord-258172-p54j4zzo 277 3 , , , cord-258172-p54j4zzo 277 4 at at IN cord-258172-p54j4zzo 277 5 present present JJ cord-258172-p54j4zzo 277 6 , , , cord-258172-p54j4zzo 277 7 there there EX cord-258172-p54j4zzo 277 8 is be VBZ cord-258172-p54j4zzo 277 9 evidence evidence NN cord-258172-p54j4zzo 277 10 that that IN cord-258172-p54j4zzo 277 11 both both CC cord-258172-p54j4zzo 277 12 short short JJ cord-258172-p54j4zzo 277 13 and and CC cord-258172-p54j4zzo 277 14 long long JJ cord-258172-p54j4zzo 277 15 forms form NNS cord-258172-p54j4zzo 277 16 of of IN cord-258172-p54j4zzo 277 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 277 18 are be VBP cord-258172-p54j4zzo 277 19 upregulated upregulate VBN cord-258172-p54j4zzo 277 20 by by IN cord-258172-p54j4zzo 277 21 interferon interferon NN cord-258172-p54j4zzo 277 22 , , , cord-258172-p54j4zzo 277 23 however however RB cord-258172-p54j4zzo 277 24 the the DT cord-258172-p54j4zzo 277 25 short short JJ cord-258172-p54j4zzo 277 26 form form NN cord-258172-p54j4zzo 277 27 appears appear VBZ cord-258172-p54j4zzo 277 28 to to TO cord-258172-p54j4zzo 277 29 be be VB cord-258172-p54j4zzo 277 30 more more RBR cord-258172-p54j4zzo 277 31 strongly strongly RB cord-258172-p54j4zzo 277 32 upregulated upregulate VBN cord-258172-p54j4zzo 277 33 , , , cord-258172-p54j4zzo 277 34 appears appear VBZ cord-258172-p54j4zzo 277 35 to to TO cord-258172-p54j4zzo 277 36 be be VB cord-258172-p54j4zzo 277 37 expressed express VBN cord-258172-p54j4zzo 277 38 at at IN cord-258172-p54j4zzo 277 39 higher high JJR cord-258172-p54j4zzo 277 40 levels level NNS cord-258172-p54j4zzo 277 41 in in IN cord-258172-p54j4zzo 277 42 nose nose NN cord-258172-p54j4zzo 277 43 and and CC cord-258172-p54j4zzo 277 44 mouth mouth NN cord-258172-p54j4zzo 277 45 , , , cord-258172-p54j4zzo 277 46 and and CC cord-258172-p54j4zzo 277 47 lacks lack VBZ cord-258172-p54j4zzo 277 48 the the DT cord-258172-p54j4zzo 277 49 domains domain NNS cord-258172-p54j4zzo 277 50 currently currently RB cord-258172-p54j4zzo 277 51 understood understand VBN cord-258172-p54j4zzo 277 52 to to TO cord-258172-p54j4zzo 277 53 bind bind VB cord-258172-p54j4zzo 277 54 the the DT cord-258172-p54j4zzo 277 55 SARS SARS NNP cord-258172-p54j4zzo 277 56 - - HYPH cord-258172-p54j4zzo 277 57 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 277 58 spike spike NN cord-258172-p54j4zzo 277 59 protein protein NN cord-258172-p54j4zzo 277 60 . . . cord-258172-p54j4zzo 278 1 Our -PRON- PRP$ cord-258172-p54j4zzo 278 2 results result NNS cord-258172-p54j4zzo 278 3 show show VBP cord-258172-p54j4zzo 278 4 significant significant JJ cord-258172-p54j4zzo 278 5 predictions prediction NNS cord-258172-p54j4zzo 278 6 for for IN cord-258172-p54j4zzo 278 7 interferon interferon NN cord-258172-p54j4zzo 278 8 response response NN cord-258172-p54j4zzo 278 9 elements element NNS cord-258172-p54j4zzo 278 10 in in IN cord-258172-p54j4zzo 278 11 the the DT cord-258172-p54j4zzo 278 12 proximal proximal JJ cord-258172-p54j4zzo 278 13 promoters promoter NNS cord-258172-p54j4zzo 278 14 of of IN cord-258172-p54j4zzo 278 15 all all DT cord-258172-p54j4zzo 278 16 three three CD cord-258172-p54j4zzo 278 17 ACE2 ACE2 NNP cord-258172-p54j4zzo 278 18 transcripts transcript NNS cord-258172-p54j4zzo 278 19 . . . cord-258172-p54j4zzo 279 1 Further further RB cord-258172-p54j4zzo 279 2 deepening deepen VBG cord-258172-p54j4zzo 279 3 the the DT cord-258172-p54j4zzo 279 4 importance importance NN cord-258172-p54j4zzo 279 5 of of IN cord-258172-p54j4zzo 279 6 understanding understand VBG cord-258172-p54j4zzo 279 7 the the DT cord-258172-p54j4zzo 279 8 role role NN cord-258172-p54j4zzo 279 9 of of IN cord-258172-p54j4zzo 279 10 interferon interferon NN cord-258172-p54j4zzo 279 11 in in IN cord-258172-p54j4zzo 279 12 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 279 13 is be VBZ cord-258172-p54j4zzo 279 14 a a DT cord-258172-p54j4zzo 279 15 new new JJ cord-258172-p54j4zzo 279 16 study study NN cord-258172-p54j4zzo 279 17 showing show VBG cord-258172-p54j4zzo 279 18 that that IN cord-258172-p54j4zzo 279 19 the the DT cord-258172-p54j4zzo 279 20 presence presence NN cord-258172-p54j4zzo 279 21 of of IN cord-258172-p54j4zzo 279 22 auto auto NN cord-258172-p54j4zzo 279 23 - - HYPH cord-258172-p54j4zzo 279 24 antibodies antibody NNS cord-258172-p54j4zzo 279 25 against against IN cord-258172-p54j4zzo 279 26 either either DT cord-258172-p54j4zzo 279 27 or or CC cord-258172-p54j4zzo 279 28 both both DT cord-258172-p54j4zzo 279 29 of of IN cord-258172-p54j4zzo 279 30 interferon interferon NNP cord-258172-p54j4zzo 279 31 alpha alpha NNP cord-258172-p54j4zzo 279 32 ( ( -LRB- cord-258172-p54j4zzo 279 33 IFNα IFNα NNP cord-258172-p54j4zzo 279 34 ) ) -RRB- cord-258172-p54j4zzo 279 35 and and CC cord-258172-p54j4zzo 279 36 interferon interferon NNP cord-258172-p54j4zzo 279 37 omega omega NNP cord-258172-p54j4zzo 279 38 ( ( -LRB- cord-258172-p54j4zzo 279 39 IFNω IFNω NNP cord-258172-p54j4zzo 279 40 ) ) -RRB- cord-258172-p54j4zzo 279 41 were be VBD cord-258172-p54j4zzo 279 42 rare rare JJ cord-258172-p54j4zzo 279 43 in in IN cord-258172-p54j4zzo 279 44 healthy healthy JJ cord-258172-p54j4zzo 279 45 , , , cord-258172-p54j4zzo 279 46 asymptomatic asymptomatic JJ cord-258172-p54j4zzo 279 47 , , , cord-258172-p54j4zzo 279 48 or or CC cord-258172-p54j4zzo 279 49 mild mild JJ cord-258172-p54j4zzo 279 50 SARS SARS NNP cord-258172-p54j4zzo 279 51 - - HYPH cord-258172-p54j4zzo 279 52 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 279 53 infection infection NN cord-258172-p54j4zzo 279 54 , , , cord-258172-p54j4zzo 279 55 but but CC cord-258172-p54j4zzo 279 56 over over RB cord-258172-p54j4zzo 279 57 - - HYPH cord-258172-p54j4zzo 279 58 represented represent VBN cord-258172-p54j4zzo 279 59 among among IN cord-258172-p54j4zzo 279 60 patients patient NNS cord-258172-p54j4zzo 279 61 with with IN cord-258172-p54j4zzo 279 62 life life NN cord-258172-p54j4zzo 279 63 - - HYPH cord-258172-p54j4zzo 279 64 threatening threaten VBG cord-258172-p54j4zzo 279 65 COVID-19 covid-19 JJ cord-258172-p54j4zzo 279 66 pneumonia pneumonia NN cord-258172-p54j4zzo 279 67 [ [ -LRB- cord-258172-p54j4zzo 279 68 82 82 CD cord-258172-p54j4zzo 279 69 ] ] -RRB- cord-258172-p54j4zzo 279 70 . . . cord-258172-p54j4zzo 280 1 The the DT cord-258172-p54j4zzo 280 2 full full JJ cord-258172-p54j4zzo 280 3 story story NN cord-258172-p54j4zzo 280 4 of of IN cord-258172-p54j4zzo 280 5 the the DT cord-258172-p54j4zzo 280 6 regulation regulation NN cord-258172-p54j4zzo 280 7 of of IN cord-258172-p54j4zzo 280 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 280 9 expression expression NN cord-258172-p54j4zzo 280 10 remains remain VBZ cord-258172-p54j4zzo 280 11 an an DT cord-258172-p54j4zzo 280 12 enigma enigma NN cord-258172-p54j4zzo 280 13 and and CC cord-258172-p54j4zzo 280 14 there there EX cord-258172-p54j4zzo 280 15 appear appear VBP cord-258172-p54j4zzo 280 16 to to TO cord-258172-p54j4zzo 280 17 be be VB cord-258172-p54j4zzo 280 18 many many JJ cord-258172-p54j4zzo 280 19 factors factor NNS cord-258172-p54j4zzo 280 20 involved involve VBN cord-258172-p54j4zzo 280 21 . . . cord-258172-p54j4zzo 281 1 One one CD cord-258172-p54j4zzo 281 2 limitation limitation NN cord-258172-p54j4zzo 281 3 of of IN cord-258172-p54j4zzo 281 4 our -PRON- PRP$ cord-258172-p54j4zzo 281 5 study study NN cord-258172-p54j4zzo 281 6 is be VBZ cord-258172-p54j4zzo 281 7 that that IN cord-258172-p54j4zzo 281 8 it -PRON- PRP cord-258172-p54j4zzo 281 9 is be VBZ cord-258172-p54j4zzo 281 10 focused focus VBN cord-258172-p54j4zzo 281 11 on on IN cord-258172-p54j4zzo 281 12 mRNA mRNA NNP cord-258172-p54j4zzo 281 13 expression expression NN cord-258172-p54j4zzo 281 14 and and CC cord-258172-p54j4zzo 281 15 transcriptional transcriptional JJ cord-258172-p54j4zzo 281 16 regulation regulation NN cord-258172-p54j4zzo 281 17 only only RB cord-258172-p54j4zzo 281 18 . . . cord-258172-p54j4zzo 282 1 There there EX cord-258172-p54j4zzo 282 2 may may MD cord-258172-p54j4zzo 282 3 exist exist VB cord-258172-p54j4zzo 282 4 factors factor NNS cord-258172-p54j4zzo 282 5 which which WDT cord-258172-p54j4zzo 282 6 function function VBP cord-258172-p54j4zzo 282 7 at at IN cord-258172-p54j4zzo 282 8 posttranscriptional posttranscriptional JJ cord-258172-p54j4zzo 282 9 level level NN cord-258172-p54j4zzo 282 10 . . . cord-258172-p54j4zzo 283 1 Indeed indeed RB cord-258172-p54j4zzo 283 2 , , , cord-258172-p54j4zzo 283 3 Srivastava Srivastava NNP cord-258172-p54j4zzo 283 4 and and CC cord-258172-p54j4zzo 283 5 colleagues colleague NNS cord-258172-p54j4zzo 283 6 recently recently RB cord-258172-p54j4zzo 283 7 demonstrated demonstrate VBD cord-258172-p54j4zzo 283 8 that that IN cord-258172-p54j4zzo 283 9 SARS SARS NNP cord-258172-p54j4zzo 283 10 - - HYPH cord-258172-p54j4zzo 283 11 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 283 12 infection infection NN cord-258172-p54j4zzo 283 13 induces induce VBZ cord-258172-p54j4zzo 283 14 alterations alteration NNS cord-258172-p54j4zzo 283 15 in in IN cord-258172-p54j4zzo 283 16 the the DT cord-258172-p54j4zzo 283 17 post post JJ cord-258172-p54j4zzo 283 18 - - JJ cord-258172-p54j4zzo 283 19 transcriptional transcriptional JJ cord-258172-p54j4zzo 283 20 regulatory regulatory JJ cord-258172-p54j4zzo 283 21 networks network NNS cord-258172-p54j4zzo 283 22 in in IN cord-258172-p54j4zzo 283 23 human human JJ cord-258172-p54j4zzo 283 24 tissues tissue NNS cord-258172-p54j4zzo 283 25 through through IN cord-258172-p54j4zzo 283 26 the the DT cord-258172-p54j4zzo 283 27 function function NN cord-258172-p54j4zzo 283 28 of of IN cord-258172-p54j4zzo 283 29 RNA RNA NNP cord-258172-p54j4zzo 283 30 binding bind VBG cord-258172-p54j4zzo 283 31 proteins protein NNS cord-258172-p54j4zzo 283 32 and and CC cord-258172-p54j4zzo 283 33 micro micro NNS cord-258172-p54j4zzo 283 34 - - NNS cord-258172-p54j4zzo 283 35 RNAs rna NNS cord-258172-p54j4zzo 283 36 [ [ -LRB- cord-258172-p54j4zzo 283 37 83 83 CD cord-258172-p54j4zzo 283 38 ] ] -RRB- cord-258172-p54j4zzo 283 39 . . . cord-258172-p54j4zzo 284 1 There there EX cord-258172-p54j4zzo 284 2 has have VBZ cord-258172-p54j4zzo 284 3 been be VBN cord-258172-p54j4zzo 284 4 clinical clinical JJ cord-258172-p54j4zzo 284 5 concern concern NN cord-258172-p54j4zzo 284 6 that that IN cord-258172-p54j4zzo 284 7 the the DT cord-258172-p54j4zzo 284 8 use use NN cord-258172-p54j4zzo 284 9 of of IN cord-258172-p54j4zzo 284 10 ACE ace NN cord-258172-p54j4zzo 284 11 inhibitors inhibitor NNS cord-258172-p54j4zzo 284 12 and and CC cord-258172-p54j4zzo 284 13 angiotensin angiotensin NN cord-258172-p54j4zzo 284 14 receptor receptor NN cord-258172-p54j4zzo 284 15 blockers blocker NNS cord-258172-p54j4zzo 284 16 could could MD cord-258172-p54j4zzo 284 17 increase increase VB cord-258172-p54j4zzo 284 18 the the DT cord-258172-p54j4zzo 284 19 expression expression NN cord-258172-p54j4zzo 284 20 of of IN cord-258172-p54j4zzo 284 21 ACE2 ACE2 NNP cord-258172-p54j4zzo 284 22 and and CC cord-258172-p54j4zzo 284 23 increase increase VB cord-258172-p54j4zzo 284 24 patient patient JJ cord-258172-p54j4zzo 284 25 susceptibility susceptibility NN cord-258172-p54j4zzo 284 26 to to IN cord-258172-p54j4zzo 284 27 viral viral JJ cord-258172-p54j4zzo 284 28 host host NN cord-258172-p54j4zzo 284 29 cell cell NN cord-258172-p54j4zzo 284 30 entry entry NN cord-258172-p54j4zzo 284 31 [ [ -LRB- cord-258172-p54j4zzo 284 32 84 84 CD cord-258172-p54j4zzo 284 33 , , , cord-258172-p54j4zzo 284 34 85 85 CD cord-258172-p54j4zzo 284 35 ] ] -RRB- cord-258172-p54j4zzo 284 36 . . . cord-258172-p54j4zzo 285 1 Previous previous JJ cord-258172-p54j4zzo 285 2 studies study NNS cord-258172-p54j4zzo 285 3 have have VBP cord-258172-p54j4zzo 285 4 suggested suggest VBN cord-258172-p54j4zzo 285 5 that that IN cord-258172-p54j4zzo 285 6 both both CC cord-258172-p54j4zzo 285 7 ACE ACE NNP cord-258172-p54j4zzo 285 8 inhibitor inhibitor NN cord-258172-p54j4zzo 285 9 and and CC cord-258172-p54j4zzo 285 10 angiotensin angiotensin NN cord-258172-p54j4zzo 285 11 II II NNP cord-258172-p54j4zzo 285 12 receptor receptor NN cord-258172-p54j4zzo 285 13 type type NN cord-258172-p54j4zzo 285 14 I -PRON- PRP cord-258172-p54j4zzo 285 15 antagonist antagonist NN cord-258172-p54j4zzo 285 16 therapies therapy NNS cord-258172-p54j4zzo 285 17 increase increase VBP cord-258172-p54j4zzo 285 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 285 19 mRNA mrna NN cord-258172-p54j4zzo 285 20 expression expression NN cord-258172-p54j4zzo 285 21 in in IN cord-258172-p54j4zzo 285 22 rat rat NN cord-258172-p54j4zzo 285 23 heart heart NN cord-258172-p54j4zzo 285 24 [ [ -LRB- cord-258172-p54j4zzo 285 25 86 86 CD cord-258172-p54j4zzo 285 26 ] ] -RRB- cord-258172-p54j4zzo 285 27 . . . cord-258172-p54j4zzo 286 1 There there EX cord-258172-p54j4zzo 286 2 has have VBZ cord-258172-p54j4zzo 286 3 also also RB cord-258172-p54j4zzo 286 4 been be VBN cord-258172-p54j4zzo 286 5 some some DT cord-258172-p54j4zzo 286 6 evidence evidence NN cord-258172-p54j4zzo 286 7 in in IN cord-258172-p54j4zzo 286 8 humans human NNS cord-258172-p54j4zzo 286 9 showing show VBG cord-258172-p54j4zzo 286 10 increased increase VBN cord-258172-p54j4zzo 286 11 expression expression NN cord-258172-p54j4zzo 286 12 of of IN cord-258172-p54j4zzo 286 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 286 14 in in IN cord-258172-p54j4zzo 286 15 the the DT cord-258172-p54j4zzo 286 16 heart heart NN cord-258172-p54j4zzo 286 17 , , , cord-258172-p54j4zzo 286 18 brain brain NN cord-258172-p54j4zzo 286 19 , , , cord-258172-p54j4zzo 286 20 and and CC cord-258172-p54j4zzo 286 21 even even RB cord-258172-p54j4zzo 286 22 in in IN cord-258172-p54j4zzo 286 23 urine urine NN cord-258172-p54j4zzo 286 24 after after IN cord-258172-p54j4zzo 286 25 treatment treatment NN cord-258172-p54j4zzo 286 26 with with IN cord-258172-p54j4zzo 286 27 angiotensin angiotensin NN cord-258172-p54j4zzo 286 28 receptor receptor NN cord-258172-p54j4zzo 286 29 blockers blocker NNS cord-258172-p54j4zzo 286 30 [ [ -LRB- cord-258172-p54j4zzo 286 31 84 84 CD cord-258172-p54j4zzo 286 32 ] ] -RRB- cord-258172-p54j4zzo 286 33 . . . cord-258172-p54j4zzo 287 1 Since since IN cord-258172-p54j4zzo 287 2 these these DT cord-258172-p54j4zzo 287 3 drugs drug NNS cord-258172-p54j4zzo 287 4 are be VBP cord-258172-p54j4zzo 287 5 widely widely RB cord-258172-p54j4zzo 287 6 used use VBN cord-258172-p54j4zzo 287 7 for for IN cord-258172-p54j4zzo 287 8 treatment treatment NN cord-258172-p54j4zzo 287 9 of of IN cord-258172-p54j4zzo 287 10 hypertension hypertension NN cord-258172-p54j4zzo 287 11 and and CC cord-258172-p54j4zzo 287 12 heart heart NN cord-258172-p54j4zzo 287 13 failure failure NN cord-258172-p54j4zzo 287 14 , , , cord-258172-p54j4zzo 287 15 it -PRON- PRP cord-258172-p54j4zzo 287 16 would would MD cord-258172-p54j4zzo 287 17 be be VB cord-258172-p54j4zzo 287 18 important important JJ cord-258172-p54j4zzo 287 19 to to TO cord-258172-p54j4zzo 287 20 determine determine VB cord-258172-p54j4zzo 287 21 in in IN cord-258172-p54j4zzo 287 22 COVID-19 covid-19 CD cord-258172-p54j4zzo 287 23 patients patient NNS cord-258172-p54j4zzo 287 24 whether whether IN cord-258172-p54j4zzo 287 25 these these DT cord-258172-p54j4zzo 287 26 medications medication NNS cord-258172-p54j4zzo 287 27 have have VBP cord-258172-p54j4zzo 287 28 any any DT cord-258172-p54j4zzo 287 29 significant significant JJ cord-258172-p54j4zzo 287 30 effects effect NNS cord-258172-p54j4zzo 287 31 on on IN cord-258172-p54j4zzo 287 32 symptoms symptom NNS cord-258172-p54j4zzo 287 33 or or CC cord-258172-p54j4zzo 287 34 outcome outcome NN cord-258172-p54j4zzo 287 35 of of IN cord-258172-p54j4zzo 287 36 the the DT cord-258172-p54j4zzo 287 37 disease disease NN cord-258172-p54j4zzo 287 38 . . . cord-258172-p54j4zzo 288 1 Gene gene NN cord-258172-p54j4zzo 288 2 ontology ontology NN cord-258172-p54j4zzo 288 3 investigations investigation NNS cord-258172-p54j4zzo 288 4 revealed reveal VBD cord-258172-p54j4zzo 288 5 interesting interesting JJ cord-258172-p54j4zzo 288 6 novel novel JJ cord-258172-p54j4zzo 288 7 data datum NNS cord-258172-p54j4zzo 288 8 on on IN cord-258172-p54j4zzo 288 9 potential potential JJ cord-258172-p54j4zzo 288 10 physiological physiological JJ cord-258172-p54j4zzo 288 11 roles role NNS cord-258172-p54j4zzo 288 12 of of IN cord-258172-p54j4zzo 288 13 ACE2 ACE2 NNP cord-258172-p54j4zzo 288 14 . . . cord-258172-p54j4zzo 289 1 The the DT cord-258172-p54j4zzo 289 2 five five CD cord-258172-p54j4zzo 289 3 most most RBS cord-258172-p54j4zzo 289 4 significant significant JJ cord-258172-p54j4zzo 289 5 gene gene NN cord-258172-p54j4zzo 289 6 ontology ontology NN cord-258172-p54j4zzo 289 7 terms term NNS cord-258172-p54j4zzo 289 8 included include VBD cord-258172-p54j4zzo 289 9 angiogenesis angiogenesis NN cord-258172-p54j4zzo 289 10 , , , cord-258172-p54j4zzo 289 11 blood blood NN cord-258172-p54j4zzo 289 12 vessel vessel NN cord-258172-p54j4zzo 289 13 morphogenesis morphogenesis NN cord-258172-p54j4zzo 289 14 , , , cord-258172-p54j4zzo 289 15 vasculature vasculature NN cord-258172-p54j4zzo 289 16 development development NN cord-258172-p54j4zzo 289 17 , , , cord-258172-p54j4zzo 289 18 cardiovascular cardiovascular JJ cord-258172-p54j4zzo 289 19 system system NN cord-258172-p54j4zzo 289 20 development development NN cord-258172-p54j4zzo 289 21 , , , cord-258172-p54j4zzo 289 22 and and CC cord-258172-p54j4zzo 289 23 blood blood NN cord-258172-p54j4zzo 289 24 vessel vessel NN cord-258172-p54j4zzo 289 25 development development NN cord-258172-p54j4zzo 289 26 . . . cord-258172-p54j4zzo 290 1 Angiotensin-(1 Angiotensin-(1 NNP cord-258172-p54j4zzo 290 2 - - HYPH cord-258172-p54j4zzo 290 3 7 7 CD cord-258172-p54j4zzo 290 4 ) ) -RRB- cord-258172-p54j4zzo 290 5 is be VBZ cord-258172-p54j4zzo 290 6 a a DT cord-258172-p54j4zzo 290 7 direct direct JJ cord-258172-p54j4zzo 290 8 product product NN cord-258172-p54j4zzo 290 9 of of IN cord-258172-p54j4zzo 290 10 ACE2 ACE2 NNP cord-258172-p54j4zzo 290 11 , , , cord-258172-p54j4zzo 290 12 and and CC cord-258172-p54j4zzo 290 13 through through IN cord-258172-p54j4zzo 290 14 binding bind VBG cord-258172-p54j4zzo 290 15 with with IN cord-258172-p54j4zzo 290 16 the the DT cord-258172-p54j4zzo 290 17 Mas Mas NNP cord-258172-p54j4zzo 290 18 receptor receptor NN cord-258172-p54j4zzo 290 19 has have VBZ cord-258172-p54j4zzo 290 20 been be VBN cord-258172-p54j4zzo 290 21 shown show VBN cord-258172-p54j4zzo 290 22 to to TO cord-258172-p54j4zzo 290 23 advance advance VB cord-258172-p54j4zzo 290 24 angiogenesis angiogenesis NN cord-258172-p54j4zzo 290 25 in in IN cord-258172-p54j4zzo 290 26 injured injure VBN cord-258172-p54j4zzo 290 27 cardiac cardiac JJ cord-258172-p54j4zzo 290 28 tissue tissue NN cord-258172-p54j4zzo 290 29 ( ( -LRB- cord-258172-p54j4zzo 290 30 myocardial myocardial JJ cord-258172-p54j4zzo 290 31 infarction infarction NN cord-258172-p54j4zzo 290 32 ) ) -RRB- cord-258172-p54j4zzo 290 33 , , , cord-258172-p54j4zzo 290 34 by by IN cord-258172-p54j4zzo 290 35 increasing increase VBG cord-258172-p54j4zzo 290 36 expression expression NN cord-258172-p54j4zzo 290 37 of of IN cord-258172-p54j4zzo 290 38 VEGF VEGF NNP cord-258172-p54j4zzo 290 39 - - HYPH cord-258172-p54j4zzo 290 40 D D NNP cord-258172-p54j4zzo 290 41 and and CC cord-258172-p54j4zzo 290 42 MMP-9 MMP-9 NNP cord-258172-p54j4zzo 290 43 [ [ -LRB- cord-258172-p54j4zzo 290 44 87 87 CD cord-258172-p54j4zzo 290 45 ] ] -RRB- cord-258172-p54j4zzo 290 46 , , , cord-258172-p54j4zzo 290 47 and and CC cord-258172-p54j4zzo 290 48 in in IN cord-258172-p54j4zzo 290 49 stroke stroke NN cord-258172-p54j4zzo 290 50 [ [ -LRB- cord-258172-p54j4zzo 290 51 88 88 CD cord-258172-p54j4zzo 290 52 ] ] -RRB- cord-258172-p54j4zzo 290 53 . . . cord-258172-p54j4zzo 291 1 Other other JJ cord-258172-p54j4zzo 291 2 studies study NNS cord-258172-p54j4zzo 291 3 have have VBP cord-258172-p54j4zzo 291 4 suggested suggest VBN cord-258172-p54j4zzo 291 5 that that IN cord-258172-p54j4zzo 291 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 291 7 , , , cord-258172-p54j4zzo 291 8 either either CC cord-258172-p54j4zzo 291 9 by by IN cord-258172-p54j4zzo 291 10 reducing reduce VBG cord-258172-p54j4zzo 291 11 angiotensin angiotensin NN cord-258172-p54j4zzo 291 12 II II NNP cord-258172-p54j4zzo 291 13 or or CC cord-258172-p54j4zzo 291 14 through through IN cord-258172-p54j4zzo 291 15 activities activity NNS cord-258172-p54j4zzo 291 16 of of IN cord-258172-p54j4zzo 291 17 the the DT cord-258172-p54j4zzo 291 18 ACE2 ACE2 NNP cord-258172-p54j4zzo 291 19 / / SYM cord-258172-p54j4zzo 291 20 angiotensin-(1 angiotensin-(1 CD cord-258172-p54j4zzo 291 21 - - HYPH cord-258172-p54j4zzo 291 22 7)/MasR 7)/masr CD cord-258172-p54j4zzo 291 23 axis axis NN cord-258172-p54j4zzo 291 24 , , , cord-258172-p54j4zzo 291 25 may may MD cord-258172-p54j4zzo 291 26 be be VB cord-258172-p54j4zzo 291 27 negatively negatively RB cord-258172-p54j4zzo 291 28 associated associate VBN cord-258172-p54j4zzo 291 29 with with IN cord-258172-p54j4zzo 291 30 angiogenesis angiogenesis NN cord-258172-p54j4zzo 291 31 in in IN cord-258172-p54j4zzo 291 32 various various JJ cord-258172-p54j4zzo 291 33 cancers cancer NNS cord-258172-p54j4zzo 291 34 [ [ -LRB- cord-258172-p54j4zzo 291 35 81 81 CD cord-258172-p54j4zzo 291 36 , , , cord-258172-p54j4zzo 291 37 [ [ -LRB- cord-258172-p54j4zzo 291 38 89 89 CD cord-258172-p54j4zzo 291 39 ] ] -RRB- cord-258172-p54j4zzo 291 40 [ [ -LRB- cord-258172-p54j4zzo 291 41 90 90 CD cord-258172-p54j4zzo 291 42 ] ] -RRB- cord-258172-p54j4zzo 291 43 [ [ -LRB- cord-258172-p54j4zzo 291 44 91 91 CD cord-258172-p54j4zzo 291 45 ] ] -RRB- cord-258172-p54j4zzo 291 46 . . . cord-258172-p54j4zzo 292 1 It -PRON- PRP cord-258172-p54j4zzo 292 2 also also RB cord-258172-p54j4zzo 292 3 appears appear VBZ cord-258172-p54j4zzo 292 4 to to TO cord-258172-p54j4zzo 292 5 play play VB cord-258172-p54j4zzo 292 6 a a DT cord-258172-p54j4zzo 292 7 role role NN cord-258172-p54j4zzo 292 8 in in IN cord-258172-p54j4zzo 292 9 angiogenesis angiogenesis NN cord-258172-p54j4zzo 292 10 in in IN cord-258172-p54j4zzo 292 11 uterus uterus NN cord-258172-p54j4zzo 292 12 during during IN cord-258172-p54j4zzo 292 13 pregnancy pregnancy NN cord-258172-p54j4zzo 292 14 [ [ -LRB- cord-258172-p54j4zzo 292 15 92 92 CD cord-258172-p54j4zzo 292 16 ] ] -RRB- cord-258172-p54j4zzo 292 17 . . . cord-258172-p54j4zzo 293 1 Our -PRON- PRP$ cord-258172-p54j4zzo 293 2 study study NN cord-258172-p54j4zzo 293 3 of of IN cord-258172-p54j4zzo 293 4 scRNA scrna XX cord-258172-p54j4zzo 293 5 - - HYPH cord-258172-p54j4zzo 293 6 Seq seq NN cord-258172-p54j4zzo 293 7 data datum NNS cord-258172-p54j4zzo 293 8 from from IN cord-258172-p54j4zzo 293 9 human human JJ cord-258172-p54j4zzo 293 10 lung lung NN cord-258172-p54j4zzo 293 11 showed show VBD cord-258172-p54j4zzo 293 12 that that IN cord-258172-p54j4zzo 293 13 the the DT cord-258172-p54j4zzo 293 14 arterial arterial JJ cord-258172-p54j4zzo 293 15 and and CC cord-258172-p54j4zzo 293 16 venous venous JJ cord-258172-p54j4zzo 293 17 vascular vascular JJ cord-258172-p54j4zzo 293 18 endothelial endothelial JJ cord-258172-p54j4zzo 293 19 cell cell NN cord-258172-p54j4zzo 293 20 types type NNS cord-258172-p54j4zzo 293 21 had have VBD cord-258172-p54j4zzo 293 22 the the DT cord-258172-p54j4zzo 293 23 highest high JJS cord-258172-p54j4zzo 293 24 ratios ratio NNS cord-258172-p54j4zzo 293 25 of of IN cord-258172-p54j4zzo 293 26 ACE2-expressing ace2-expresse VBG cord-258172-p54j4zzo 293 27 cells cell NNS cord-258172-p54j4zzo 293 28 , , , cord-258172-p54j4zzo 293 29 first first JJ cord-258172-p54j4zzo 293 30 and and CC cord-258172-p54j4zzo 293 31 third third RB cord-258172-p54j4zzo 293 32 highest high JJS cord-258172-p54j4zzo 293 33 , , , cord-258172-p54j4zzo 293 34 respectively respectively RB cord-258172-p54j4zzo 293 35 . . . cord-258172-p54j4zzo 294 1 In in IN cord-258172-p54j4zzo 294 2 another another DT cord-258172-p54j4zzo 294 3 study study NN cord-258172-p54j4zzo 294 4 , , , cord-258172-p54j4zzo 294 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 294 6 expression expression NN cord-258172-p54j4zzo 294 7 was be VBD cord-258172-p54j4zzo 294 8 detected detect VBN cord-258172-p54j4zzo 294 9 in in IN cord-258172-p54j4zzo 294 10 blood blood NN cord-258172-p54j4zzo 294 11 vessels vessel NNS cord-258172-p54j4zzo 294 12 [ [ -LRB- cord-258172-p54j4zzo 294 13 27 27 CD cord-258172-p54j4zzo 294 14 ] ] -RRB- cord-258172-p54j4zzo 294 15 , , , cord-258172-p54j4zzo 294 16 while while IN cord-258172-p54j4zzo 294 17 a a DT cord-258172-p54j4zzo 294 18 recent recent JJ cord-258172-p54j4zzo 294 19 study study NN cord-258172-p54j4zzo 294 20 showed show VBD cord-258172-p54j4zzo 294 21 that that IN cord-258172-p54j4zzo 294 22 SARS SARS NNP cord-258172-p54j4zzo 294 23 - - HYPH cord-258172-p54j4zzo 294 24 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 294 25 is be VBZ cord-258172-p54j4zzo 294 26 capable capable JJ cord-258172-p54j4zzo 294 27 of of IN cord-258172-p54j4zzo 294 28 directly directly RB cord-258172-p54j4zzo 294 29 infecting infect VBG cord-258172-p54j4zzo 294 30 blood blood NN cord-258172-p54j4zzo 294 31 vessel vessel NN cord-258172-p54j4zzo 294 32 cells cell NNS cord-258172-p54j4zzo 294 33 [ [ -LRB- cord-258172-p54j4zzo 294 34 12 12 CD cord-258172-p54j4zzo 294 35 ] ] -RRB- cord-258172-p54j4zzo 294 36 . . . cord-258172-p54j4zzo 295 1 Endothelial endothelial JJ cord-258172-p54j4zzo 295 2 ACE2 ACE2 NNP cord-258172-p54j4zzo 295 3 expression expression NN cord-258172-p54j4zzo 295 4 may may MD cord-258172-p54j4zzo 295 5 be be VB cord-258172-p54j4zzo 295 6 linked link VBN cord-258172-p54j4zzo 295 7 to to IN cord-258172-p54j4zzo 295 8 clotting clotting NN cord-258172-p54j4zzo 295 9 and and CC cord-258172-p54j4zzo 295 10 multi multi JJ cord-258172-p54j4zzo 295 11 - - JJ cord-258172-p54j4zzo 295 12 organ organ JJ cord-258172-p54j4zzo 295 13 dysfunction dysfunction NN cord-258172-p54j4zzo 295 14 reported report VBN cord-258172-p54j4zzo 295 15 in in IN cord-258172-p54j4zzo 295 16 many many JJ cord-258172-p54j4zzo 295 17 patients patient NNS cord-258172-p54j4zzo 295 18 with with IN cord-258172-p54j4zzo 295 19 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 295 20 [ [ -LRB- cord-258172-p54j4zzo 295 21 93 93 CD cord-258172-p54j4zzo 295 22 ] ] -RRB- cord-258172-p54j4zzo 295 23 . . . cord-258172-p54j4zzo 296 1 Our -PRON- PRP$ cord-258172-p54j4zzo 296 2 GO GO NNP cord-258172-p54j4zzo 296 3 analysis analysis NN cord-258172-p54j4zzo 296 4 provided provide VBD cord-258172-p54j4zzo 296 5 evidence evidence NN cord-258172-p54j4zzo 296 6 that that IN cord-258172-p54j4zzo 296 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 296 8 is be VBZ cord-258172-p54j4zzo 296 9 involved involve VBN cord-258172-p54j4zzo 296 10 in in IN cord-258172-p54j4zzo 296 11 the the DT cord-258172-p54j4zzo 296 12 KEGG KEGG NNP cord-258172-p54j4zzo 296 13 pathway pathway NN cord-258172-p54j4zzo 296 14 ' ' '' cord-258172-p54j4zzo 296 15 complement complement NN cord-258172-p54j4zzo 296 16 and and CC cord-258172-p54j4zzo 296 17 coagulation coagulation NN cord-258172-p54j4zzo 296 18 cascades cascade NNS cord-258172-p54j4zzo 296 19 ' ' '' cord-258172-p54j4zzo 296 20 . . . cord-258172-p54j4zzo 297 1 Indeed indeed RB cord-258172-p54j4zzo 297 2 , , , cord-258172-p54j4zzo 297 3 patients patient NNS cord-258172-p54j4zzo 297 4 with with IN cord-258172-p54j4zzo 297 5 severe severe JJ cord-258172-p54j4zzo 297 6 COVID-19 covid-19 NN cord-258172-p54j4zzo 297 7 often often RB cord-258172-p54j4zzo 297 8 present present JJ cord-258172-p54j4zzo 297 9 with with IN cord-258172-p54j4zzo 297 10 coagulation coagulation NN cord-258172-p54j4zzo 297 11 abnormalities abnormality NNS cord-258172-p54j4zzo 297 12 that that WDT cord-258172-p54j4zzo 297 13 mimic mimic VBP cord-258172-p54j4zzo 297 14 other other JJ cord-258172-p54j4zzo 297 15 known know VBN cord-258172-p54j4zzo 297 16 systemic systemic JJ cord-258172-p54j4zzo 297 17 coagulopathies coagulopathie NNS cord-258172-p54j4zzo 297 18 , , , cord-258172-p54j4zzo 297 19 such such JJ cord-258172-p54j4zzo 297 20 as as IN cord-258172-p54j4zzo 297 21 disseminated disseminate VBN cord-258172-p54j4zzo 297 22 intravascular intravascular JJ cord-258172-p54j4zzo 297 23 coagulation coagulation NN cord-258172-p54j4zzo 297 24 ( ( -LRB- cord-258172-p54j4zzo 297 25 DIC DIC NNP cord-258172-p54j4zzo 297 26 ) ) -RRB- cord-258172-p54j4zzo 297 27 or or CC cord-258172-p54j4zzo 297 28 thrombotic thrombotic JJ cord-258172-p54j4zzo 297 29 microangiopathy microangiopathy NNP cord-258172-p54j4zzo 297 30 , , , cord-258172-p54j4zzo 297 31 but but CC cord-258172-p54j4zzo 297 32 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 298 1 has have VBZ cord-258172-p54j4zzo 298 2 its -PRON- PRP$ cord-258172-p54j4zzo 298 3 own own JJ cord-258172-p54j4zzo 298 4 distinct distinct JJ cord-258172-p54j4zzo 298 5 features feature NNS cord-258172-p54j4zzo 298 6 [ [ -LRB- cord-258172-p54j4zzo 298 7 94 94 CD cord-258172-p54j4zzo 298 8 ] ] -RRB- cord-258172-p54j4zzo 298 9 . . . cord-258172-p54j4zzo 299 1 Based base VBN cord-258172-p54j4zzo 299 2 on on IN cord-258172-p54j4zzo 299 3 the the DT cord-258172-p54j4zzo 299 4 present present JJ cord-258172-p54j4zzo 299 5 finding finding NN cord-258172-p54j4zzo 299 6 , , , cord-258172-p54j4zzo 299 7 angiogenesis angiogenesis NN cord-258172-p54j4zzo 299 8 / / SYM cord-258172-p54j4zzo 299 9 blood blood NN cord-258172-p54j4zzo 299 10 vessel vessel NN cord-258172-p54j4zzo 299 11 morphogenesis morphogenesis NN cord-258172-p54j4zzo 299 12 may may MD cord-258172-p54j4zzo 299 13 be be VB cord-258172-p54j4zzo 299 14 considered consider VBN cord-258172-p54j4zzo 299 15 another another DT cord-258172-p54j4zzo 299 16 putative putative JJ cord-258172-p54j4zzo 299 17 function function NN cord-258172-p54j4zzo 299 18 for for IN cord-258172-p54j4zzo 299 19 ACE2 ACE2 NNP cord-258172-p54j4zzo 299 20 in in IN cord-258172-p54j4zzo 299 21 addition addition NN cord-258172-p54j4zzo 299 22 to to IN cord-258172-p54j4zzo 299 23 its -PRON- PRP$ cord-258172-p54j4zzo 299 24 classical classical JJ cord-258172-p54j4zzo 299 25 role role NN cord-258172-p54j4zzo 299 26 as as IN cord-258172-p54j4zzo 299 27 the the DT cord-258172-p54j4zzo 299 28 key key JJ cord-258172-p54j4zzo 299 29 angiotensin-(1 angiotensin-(1 CD cord-258172-p54j4zzo 299 30 - - SYM cord-258172-p54j4zzo 299 31 7 7 CD cord-258172-p54j4zzo 299 32 ) ) -RRB- cord-258172-p54j4zzo 299 33 forming form VBG cord-258172-p54j4zzo 299 34 enzyme enzyme NN cord-258172-p54j4zzo 299 35 [ [ -LRB- cord-258172-p54j4zzo 299 36 95 95 CD cord-258172-p54j4zzo 299 37 ] ] -RRB- cord-258172-p54j4zzo 299 38 . . . cord-258172-p54j4zzo 300 1 Our -PRON- PRP$ cord-258172-p54j4zzo 300 2 bioinformatics bioinformatics NN cord-258172-p54j4zzo 300 3 study study NN cord-258172-p54j4zzo 300 4 confirmed confirm VBD cord-258172-p54j4zzo 300 5 the the DT cord-258172-p54j4zzo 300 6 low low JJ cord-258172-p54j4zzo 300 7 expression expression NN cord-258172-p54j4zzo 300 8 of of IN cord-258172-p54j4zzo 300 9 ACE2 ACE2 NNP cord-258172-p54j4zzo 300 10 in in IN cord-258172-p54j4zzo 300 11 the the DT cord-258172-p54j4zzo 300 12 respiratory respiratory JJ cord-258172-p54j4zzo 300 13 tract tract NN cord-258172-p54j4zzo 300 14 . . . cord-258172-p54j4zzo 301 1 In in IN cord-258172-p54j4zzo 301 2 lung lung NN cord-258172-p54j4zzo 301 3 it -PRON- PRP cord-258172-p54j4zzo 301 4 was be VBD cord-258172-p54j4zzo 301 5 lowest low JJS cord-258172-p54j4zzo 301 6 of of IN cord-258172-p54j4zzo 301 7 all all DT cord-258172-p54j4zzo 301 8 , , , cord-258172-p54j4zzo 301 9 while while IN cord-258172-p54j4zzo 301 10 significantly significantly RB cord-258172-p54j4zzo 301 11 higher higher RBR cord-258172-p54j4zzo 301 12 in in IN cord-258172-p54j4zzo 301 13 the the DT cord-258172-p54j4zzo 301 14 trachea trachea NN cord-258172-p54j4zzo 301 15 . . . cord-258172-p54j4zzo 302 1 Bulk Bulk NNP cord-258172-p54j4zzo 302 2 RNA RNA NNP cord-258172-p54j4zzo 302 3 - - HYPH cord-258172-p54j4zzo 302 4 Seq Seq NNP cord-258172-p54j4zzo 302 5 analyses analysis NNS cord-258172-p54j4zzo 302 6 indicated indicate VBD cord-258172-p54j4zzo 302 7 the the DT cord-258172-p54j4zzo 302 8 highest high JJS cord-258172-p54j4zzo 302 9 expression expression NN cord-258172-p54j4zzo 302 10 levels level NNS cord-258172-p54j4zzo 302 11 in in IN cord-258172-p54j4zzo 302 12 the the DT cord-258172-p54j4zzo 302 13 small small JJ cord-258172-p54j4zzo 302 14 intestine intestine NN cord-258172-p54j4zzo 302 15 , , , cord-258172-p54j4zzo 302 16 colon colon NN cord-258172-p54j4zzo 302 17 , , , cord-258172-p54j4zzo 302 18 testis testis NN cord-258172-p54j4zzo 302 19 , , , cord-258172-p54j4zzo 302 20 and and CC cord-258172-p54j4zzo 302 21 kidney kidney NN cord-258172-p54j4zzo 302 22 . . . cord-258172-p54j4zzo 303 1 In in IN cord-258172-p54j4zzo 303 2 the the DT cord-258172-p54j4zzo 303 3 human human JJ cord-258172-p54j4zzo 303 4 lung lung NN cord-258172-p54j4zzo 303 5 scRNA scRNA NNP cord-258172-p54j4zzo 303 6 - - HYPH cord-258172-p54j4zzo 303 7 Seq seq NN cord-258172-p54j4zzo 303 8 dataset dataset NN cord-258172-p54j4zzo 303 9 , , , cord-258172-p54j4zzo 303 10 the the DT cord-258172-p54j4zzo 303 11 strongest strong JJS cord-258172-p54j4zzo 303 12 positive positive JJ cord-258172-p54j4zzo 303 13 signals signal NNS cord-258172-p54j4zzo 303 14 for for IN cord-258172-p54j4zzo 304 1 ACE2 ACE2 NNP cord-258172-p54j4zzo 304 2 mRNA mrna NN cord-258172-p54j4zzo 304 3 were be VBD cord-258172-p54j4zzo 304 4 observed observe VBN cord-258172-p54j4zzo 304 5 in in IN cord-258172-p54j4zzo 304 6 vascular vascular JJ cord-258172-p54j4zzo 304 7 endothelial endothelial JJ cord-258172-p54j4zzo 304 8 cells cell NNS cord-258172-p54j4zzo 304 9 , , , cord-258172-p54j4zzo 304 10 goblet goblet NN cord-258172-p54j4zzo 304 11 cells cell NNS cord-258172-p54j4zzo 304 12 , , , cord-258172-p54j4zzo 304 13 ciliated ciliated JJ cord-258172-p54j4zzo 304 14 cells cell NNS cord-258172-p54j4zzo 304 15 , , , cord-258172-p54j4zzo 304 16 and and CC cord-258172-p54j4zzo 304 17 AT2 at2 NN cord-258172-p54j4zzo 304 18 and and CC cord-258172-p54j4zzo 304 19 AT1 at1 NN cord-258172-p54j4zzo 304 20 pneumocytes pneumocyte NNS cord-258172-p54j4zzo 304 21 . . . cord-258172-p54j4zzo 305 1 In in IN cord-258172-p54j4zzo 305 2 the the DT cord-258172-p54j4zzo 305 3 mouse mouse NN cord-258172-p54j4zzo 305 4 trachea trachea NN cord-258172-p54j4zzo 305 5 dataset dataset NN cord-258172-p54j4zzo 305 6 , , , cord-258172-p54j4zzo 305 7 positive positive JJ cord-258172-p54j4zzo 305 8 signals signal NNS cord-258172-p54j4zzo 305 9 were be VBD cord-258172-p54j4zzo 305 10 most most RBS cord-258172-p54j4zzo 305 11 common common JJ cord-258172-p54j4zzo 305 12 in in IN cord-258172-p54j4zzo 305 13 club club NN cord-258172-p54j4zzo 305 14 cells cell NNS cord-258172-p54j4zzo 305 15 , , , cord-258172-p54j4zzo 305 16 goblet goblet NN cord-258172-p54j4zzo 305 17 cells cell NNS cord-258172-p54j4zzo 305 18 and and CC cord-258172-p54j4zzo 305 19 ciliated ciliated JJ cord-258172-p54j4zzo 305 20 epithelial epithelial JJ cord-258172-p54j4zzo 305 21 cells cell NNS cord-258172-p54j4zzo 305 22 . . . cord-258172-p54j4zzo 306 1 The the DT cord-258172-p54j4zzo 306 2 results result NNS cord-258172-p54j4zzo 306 3 suggest suggest VBP cord-258172-p54j4zzo 306 4 that that IN cord-258172-p54j4zzo 306 5 SARS SARS NNP cord-258172-p54j4zzo 306 6 - - HYPH cord-258172-p54j4zzo 306 7 CoV CoV NNP cord-258172-p54j4zzo 306 8 infection infection NN cord-258172-p54j4zzo 306 9 may may MD cord-258172-p54j4zzo 306 10 target target VB cord-258172-p54j4zzo 306 11 the the DT cord-258172-p54j4zzo 306 12 cell cell NN cord-258172-p54j4zzo 306 13 types type NNS cord-258172-p54j4zzo 306 14 that that WDT cord-258172-p54j4zzo 306 15 are be VBP cord-258172-p54j4zzo 306 16 important important JJ cord-258172-p54j4zzo 306 17 for for IN cord-258172-p54j4zzo 306 18 the the DT cord-258172-p54j4zzo 306 19 protection protection NN cord-258172-p54j4zzo 306 20 of of IN cord-258172-p54j4zzo 306 21 airway airway NN cord-258172-p54j4zzo 306 22 mucosa mucosa NN cord-258172-p54j4zzo 306 23 and and CC cord-258172-p54j4zzo 306 24 their -PRON- PRP$ cord-258172-p54j4zzo 306 25 damage damage NN cord-258172-p54j4zzo 306 26 may may MD cord-258172-p54j4zzo 306 27 lead lead VB cord-258172-p54j4zzo 306 28 to to IN cord-258172-p54j4zzo 306 29 deterioration deterioration NN cord-258172-p54j4zzo 306 30 of of IN cord-258172-p54j4zzo 306 31 epithelial epithelial JJ cord-258172-p54j4zzo 306 32 cell cell NN cord-258172-p54j4zzo 306 33 function function NN cord-258172-p54j4zzo 306 34 , , , cord-258172-p54j4zzo 306 35 finally finally RB cord-258172-p54j4zzo 306 36 leading lead VBG cord-258172-p54j4zzo 306 37 to to IN cord-258172-p54j4zzo 306 38 a a DT cord-258172-p54j4zzo 306 39 more more RBR cord-258172-p54j4zzo 306 40 severe severe JJ cord-258172-p54j4zzo 306 41 lung lung NN cord-258172-p54j4zzo 306 42 disease disease NN cord-258172-p54j4zzo 306 43 with with IN cord-258172-p54j4zzo 306 44 accumulation accumulation NN cord-258172-p54j4zzo 306 45 of of IN cord-258172-p54j4zzo 306 46 alveolar alveolar NN cord-258172-p54j4zzo 306 47 exudate exudate NN cord-258172-p54j4zzo 306 48 and and CC cord-258172-p54j4zzo 306 49 inflammatory inflammatory JJ cord-258172-p54j4zzo 306 50 cells cell NNS cord-258172-p54j4zzo 306 51 and and CC cord-258172-p54j4zzo 306 52 lung lung NN cord-258172-p54j4zzo 306 53 edema edema NN cord-258172-p54j4zzo 306 54 , , , cord-258172-p54j4zzo 306 55 the the DT cord-258172-p54j4zzo 306 56 signs sign NNS cord-258172-p54j4zzo 306 57 of of IN cord-258172-p54j4zzo 306 58 pneumonia pneumonia NN cord-258172-p54j4zzo 306 59 recently recently RB cord-258172-p54j4zzo 306 60 described describe VBD cord-258172-p54j4zzo 306 61 in in IN cord-258172-p54j4zzo 306 62 the the DT cord-258172-p54j4zzo 306 63 lung lung NN cord-258172-p54j4zzo 306 64 specimens specimen NNS cord-258172-p54j4zzo 306 65 of of IN cord-258172-p54j4zzo 306 66 two two CD cord-258172-p54j4zzo 306 67 patients patient NNS cord-258172-p54j4zzo 306 68 with with IN cord-258172-p54j4zzo 306 69 COVID-19 covid-19 JJ cord-258172-p54j4zzo 306 70 infection infection NN cord-258172-p54j4zzo 306 71 [ [ -LRB- cord-258172-p54j4zzo 306 72 96 96 CD cord-258172-p54j4zzo 306 73 ] ] -RRB- cord-258172-p54j4zzo 306 74 . . . cord-258172-p54j4zzo 307 1 Gene gene NN cord-258172-p54j4zzo 307 2 ontology ontology NN cord-258172-p54j4zzo 307 3 analysis analysis NN cord-258172-p54j4zzo 307 4 based base VBN cord-258172-p54j4zzo 307 5 on on IN cord-258172-p54j4zzo 307 6 expression expression NN cord-258172-p54j4zzo 307 7 in in IN cord-258172-p54j4zzo 307 8 all all DT cord-258172-p54j4zzo 307 9 tissues tissue NNS cord-258172-p54j4zzo 307 10 suggested suggest VBD cord-258172-p54j4zzo 307 11 that that IN cord-258172-p54j4zzo 307 12 ACE2 ACE2 NNP cord-258172-p54j4zzo 307 13 is be VBZ cord-258172-p54j4zzo 307 14 involved involve VBN cord-258172-p54j4zzo 307 15 in in IN cord-258172-p54j4zzo 307 16 angiogenesis/ angiogenesis/ CD cord-258172-p54j4zzo 307 17 blood blood NN cord-258172-p54j4zzo 307 18 vessel vessel NN cord-258172-p54j4zzo 307 19 morphogenesis morphogenesis NN cord-258172-p54j4zzo 307 20 processes process NNS cord-258172-p54j4zzo 307 21 in in IN cord-258172-p54j4zzo 307 22 addition addition NN cord-258172-p54j4zzo 307 23 to to IN cord-258172-p54j4zzo 307 24 its -PRON- PRP$ cord-258172-p54j4zzo 307 25 classical classical JJ cord-258172-p54j4zzo 307 26 function function NN cord-258172-p54j4zzo 307 27 in in IN cord-258172-p54j4zzo 307 28 renin renin NN cord-258172-p54j4zzo 307 29 - - HYPH cord-258172-p54j4zzo 307 30 angiotensin angiotensin NN cord-258172-p54j4zzo 307 31 system system NN cord-258172-p54j4zzo 307 32 . . . cord-258172-p54j4zzo 308 1 Many many JJ cord-258172-p54j4zzo 308 2 findings finding NNS cord-258172-p54j4zzo 308 3 reported report VBN cord-258172-p54j4zzo 308 4 here here RB cord-258172-p54j4zzo 308 5 have have VBP cord-258172-p54j4zzo 308 6 not not RB cord-258172-p54j4zzo 308 7 yet yet RB cord-258172-p54j4zzo 308 8 been be VBN cord-258172-p54j4zzo 308 9 verified verify VBN cord-258172-p54j4zzo 308 10 in in IN cord-258172-p54j4zzo 308 11 vivo vivo NN cord-258172-p54j4zzo 308 12 or or CC cord-258172-p54j4zzo 308 13 in in IN cord-258172-p54j4zzo 308 14 vitro vitro FW cord-258172-p54j4zzo 308 15 . . . cord-258172-p54j4zzo 309 1 Therefore therefore RB cord-258172-p54j4zzo 309 2 , , , cord-258172-p54j4zzo 309 3 the the DT cord-258172-p54j4zzo 309 4 validity validity NN cord-258172-p54j4zzo 309 5 of of IN cord-258172-p54j4zzo 309 6 the the DT cord-258172-p54j4zzo 309 7 bioinformatics bioinformatics NN cord-258172-p54j4zzo 309 8 results result NNS cord-258172-p54j4zzo 309 9 needs need VBZ cord-258172-p54j4zzo 309 10 to to TO cord-258172-p54j4zzo 309 11 be be VB cord-258172-p54j4zzo 309 12 verified verify VBN cord-258172-p54j4zzo 309 13 by by IN cord-258172-p54j4zzo 309 14 future future JJ cord-258172-p54j4zzo 309 15 experimental experimental JJ cord-258172-p54j4zzo 309 16 research research NN cord-258172-p54j4zzo 309 17 . . . cord-258172-p54j4zzo 309 18 _SP cord-258172-p54j4zzo 310 1 The the DT cord-258172-p54j4zzo 310 2 preparation preparation NN cord-258172-p54j4zzo 310 3 and and CC cord-258172-p54j4zzo 310 4 function function NN cord-258172-p54j4zzo 310 5 of of IN cord-258172-p54j4zzo 310 6 the the DT cord-258172-p54j4zzo 310 7 hypertensin hypertensin NN cord-258172-p54j4zzo 310 8 - - HYPH cord-258172-p54j4zzo 310 9 converting convert VBG cord-258172-p54j4zzo 310 10 enzyme enzyme NN cord-258172-p54j4zzo 310 11 A a DT cord-258172-p54j4zzo 310 12 novel novel JJ cord-258172-p54j4zzo 310 13 angiotensin angiotensin NN cord-258172-p54j4zzo 310 14 - - HYPH cord-258172-p54j4zzo 310 15 converting convert VBG cord-258172-p54j4zzo 310 16 enzyme enzyme NN cord-258172-p54j4zzo 310 17 - - HYPH cord-258172-p54j4zzo 310 18 related relate VBN cord-258172-p54j4zzo 310 19 carboxypeptidase carboxypeptidase NN cord-258172-p54j4zzo 310 20 ( ( -LRB- cord-258172-p54j4zzo 310 21 ACE2 ACE2 NNP cord-258172-p54j4zzo 310 22 ) ) -RRB- cord-258172-p54j4zzo 310 23 converts convert VBZ cord-258172-p54j4zzo 310 24 angiotensin angiotensin NN cord-258172-p54j4zzo 310 25 I -PRON- PRP cord-258172-p54j4zzo 310 26 to to IN cord-258172-p54j4zzo 310 27 angiotensin angiotensin NN cord-258172-p54j4zzo 310 28 1 1 CD cord-258172-p54j4zzo 310 29 - - SYM cord-258172-p54j4zzo 310 30 9 9 CD cord-258172-p54j4zzo 311 1 Some some DT cord-258172-p54j4zzo 311 2 properties property NNS cord-258172-p54j4zzo 311 3 of of IN cord-258172-p54j4zzo 311 4 carbonic carbonic JJ cord-258172-p54j4zzo 311 5 anhydrase anhydrase NN cord-258172-p54j4zzo 311 6 , , , cord-258172-p54j4zzo 311 7 the the DT cord-258172-p54j4zzo 311 8 CO2 CO2 NNP cord-258172-p54j4zzo 311 9 enzyme enzyme NN cord-258172-p54j4zzo 311 10 present present NN cord-258172-p54j4zzo 311 11 in in IN cord-258172-p54j4zzo 311 12 blood blood NN cord-258172-p54j4zzo 311 13 Zinc zinc NN cord-258172-p54j4zzo 311 14 through through IN cord-258172-p54j4zzo 311 15 the the DT cord-258172-p54j4zzo 311 16 three three CD cord-258172-p54j4zzo 311 17 domains domain NNS cord-258172-p54j4zzo 311 18 of of IN cord-258172-p54j4zzo 311 19 life life NN cord-258172-p54j4zzo 311 20 Counting count VBG cord-258172-p54j4zzo 311 21 the the DT cord-258172-p54j4zzo 311 22 zinc zinc NN cord-258172-p54j4zzo 311 23 - - HYPH cord-258172-p54j4zzo 311 24 proteins protein NNS cord-258172-p54j4zzo 311 25 encoded encode VBN cord-258172-p54j4zzo 311 26 in in IN cord-258172-p54j4zzo 311 27 the the DT cord-258172-p54j4zzo 311 28 human human JJ cord-258172-p54j4zzo 311 29 genome genome NN cord-258172-p54j4zzo 311 30 Cloning cloning NN cord-258172-p54j4zzo 311 31 and and CC cord-258172-p54j4zzo 311 32 functional functional JJ cord-258172-p54j4zzo 311 33 expression expression NN cord-258172-p54j4zzo 311 34 as as IN cord-258172-p54j4zzo 311 35 a a DT cord-258172-p54j4zzo 311 36 captopril captopril NN cord-258172-p54j4zzo 311 37 - - HYPH cord-258172-p54j4zzo 311 38 insensitive insensitive JJ cord-258172-p54j4zzo 311 39 carboxypeptidase carboxypeptidase NN cord-258172-p54j4zzo 311 40 The the DT cord-258172-p54j4zzo 311 41 novel novel JJ cord-258172-p54j4zzo 311 42 angiotensin angiotensin NN cord-258172-p54j4zzo 311 43 - - HYPH cord-258172-p54j4zzo 311 44 converting convert VBG cord-258172-p54j4zzo 311 45 enzyme enzyme NN cord-258172-p54j4zzo 311 46 ( ( -LRB- cord-258172-p54j4zzo 311 47 ACE ace NN cord-258172-p54j4zzo 311 48 ) ) -RRB- cord-258172-p54j4zzo 311 49 homolog homolog NN cord-258172-p54j4zzo 311 50 , , , cord-258172-p54j4zzo 311 51 ACE2 ACE2 NNP cord-258172-p54j4zzo 311 52 , , , cord-258172-p54j4zzo 311 53 is be VBZ cord-258172-p54j4zzo 311 54 selectively selectively RB cord-258172-p54j4zzo 311 55 expressed express VBN cord-258172-p54j4zzo 311 56 by by IN cord-258172-p54j4zzo 311 57 adult adult NN cord-258172-p54j4zzo 311 58 Leydig Leydig NNP cord-258172-p54j4zzo 311 59 cells cell NNS cord-258172-p54j4zzo 311 60 of of IN cord-258172-p54j4zzo 311 61 the the DT cord-258172-p54j4zzo 311 62 testis testis NN cord-258172-p54j4zzo 311 63 . . . cord-258172-p54j4zzo 312 1 Endocrinology Endocrinology NNP cord-258172-p54j4zzo 313 1 The the DT cord-258172-p54j4zzo 313 2 discovery discovery NN cord-258172-p54j4zzo 313 3 of of IN cord-258172-p54j4zzo 313 4 angiotensin angiotensin NN cord-258172-p54j4zzo 313 5 - - HYPH cord-258172-p54j4zzo 313 6 converting convert VBG cord-258172-p54j4zzo 313 7 enzyme enzyme NN cord-258172-p54j4zzo 313 8 2 2 CD cord-258172-p54j4zzo 313 9 and and CC cord-258172-p54j4zzo 313 10 its -PRON- PRP$ cord-258172-p54j4zzo 313 11 role role NN cord-258172-p54j4zzo 313 12 in in IN cord-258172-p54j4zzo 313 13 acute acute JJ cord-258172-p54j4zzo 313 14 lung lung NN cord-258172-p54j4zzo 313 15 injury injury NN cord-258172-p54j4zzo 313 16 in in IN cord-258172-p54j4zzo 313 17 mice mice NNP cord-258172-p54j4zzo 313 18 Organ organ NN cord-258172-p54j4zzo 313 19 - - HYPH cord-258172-p54j4zzo 313 20 protective protective JJ cord-258172-p54j4zzo 313 21 effect effect NN cord-258172-p54j4zzo 313 22 of of IN cord-258172-p54j4zzo 313 23 angiotensin angiotensin NN cord-258172-p54j4zzo 313 24 - - HYPH cord-258172-p54j4zzo 313 25 converting convert VBG cord-258172-p54j4zzo 313 26 enzyme enzyme NN cord-258172-p54j4zzo 313 27 2 2 CD cord-258172-p54j4zzo 313 28 and and CC cord-258172-p54j4zzo 313 29 its -PRON- PRP$ cord-258172-p54j4zzo 313 30 effect effect NN cord-258172-p54j4zzo 313 31 on on IN cord-258172-p54j4zzo 313 32 the the DT cord-258172-p54j4zzo 313 33 prognosis prognosis NN cord-258172-p54j4zzo 313 34 of of IN cord-258172-p54j4zzo 313 35 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 313 36 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 313 37 - - HYPH cord-258172-p54j4zzo 313 38 converting convert VBG cord-258172-p54j4zzo 313 39 enzyme enzyme NN cord-258172-p54j4zzo 313 40 2 2 CD cord-258172-p54j4zzo 313 41 is be VBZ cord-258172-p54j4zzo 313 42 a a DT cord-258172-p54j4zzo 313 43 functional functional JJ cord-258172-p54j4zzo 313 44 receptor receptor NN cord-258172-p54j4zzo 313 45 for for IN cord-258172-p54j4zzo 313 46 the the DT cord-258172-p54j4zzo 313 47 SARS SARS NNP cord-258172-p54j4zzo 313 48 coronavirus coronavirus NN cord-258172-p54j4zzo 313 49 Neutralization neutralization NN cord-258172-p54j4zzo 313 50 of of IN cord-258172-p54j4zzo 313 51 SARS SARS NNP cord-258172-p54j4zzo 313 52 - - HYPH cord-258172-p54j4zzo 313 53 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 313 54 spike spike NN cord-258172-p54j4zzo 313 55 pseudotyped pseudotype VBD cord-258172-p54j4zzo 313 56 virus virus NN cord-258172-p54j4zzo 313 57 by by IN cord-258172-p54j4zzo 313 58 recombinant recombinant JJ cord-258172-p54j4zzo 313 59 ACE2-Ig ACE2-Ig NNP cord-258172-p54j4zzo 313 60 Inhibition Inhibition NNP cord-258172-p54j4zzo 313 61 of of IN cord-258172-p54j4zzo 313 62 SARS SARS NNP cord-258172-p54j4zzo 313 63 - - HYPH cord-258172-p54j4zzo 313 64 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 313 65 infections infection NNS cord-258172-p54j4zzo 313 66 in in IN cord-258172-p54j4zzo 313 67 engineered engineer VBN cord-258172-p54j4zzo 313 68 human human JJ cord-258172-p54j4zzo 313 69 tissues tissue NNS cord-258172-p54j4zzo 313 70 using use VBG cord-258172-p54j4zzo 313 71 clinical clinical JJ cord-258172-p54j4zzo 313 72 - - HYPH cord-258172-p54j4zzo 313 73 grade grade NN cord-258172-p54j4zzo 313 74 soluble soluble JJ cord-258172-p54j4zzo 313 75 human human JJ cord-258172-p54j4zzo 313 76 ACE2 ACE2 NNP cord-258172-p54j4zzo 313 77 SARS SARS NNP cord-258172-p54j4zzo 313 78 - - HYPH cord-258172-p54j4zzo 313 79 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 313 80 Cell Cell NNP cord-258172-p54j4zzo 313 81 Entry entry NN cord-258172-p54j4zzo 314 1 Depends depend VBZ cord-258172-p54j4zzo 314 2 on on IN cord-258172-p54j4zzo 314 3 ACE2 ACE2 NNP cord-258172-p54j4zzo 314 4 and and CC cord-258172-p54j4zzo 314 5 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 314 6 and and CC cord-258172-p54j4zzo 315 1 Is be VBZ cord-258172-p54j4zzo 315 2 Blocked block VBN cord-258172-p54j4zzo 315 3 by by IN cord-258172-p54j4zzo 315 4 a a DT cord-258172-p54j4zzo 315 5 Clinically clinically RB cord-258172-p54j4zzo 315 6 Proven prove VBN cord-258172-p54j4zzo 315 7 Protease protease NN cord-258172-p54j4zzo 315 8 Inhibitor Inhibitor NNP cord-258172-p54j4zzo 315 9 A a DT cord-258172-p54j4zzo 315 10 transmembrane transmembrane NN cord-258172-p54j4zzo 315 11 serine serine NN cord-258172-p54j4zzo 315 12 protease protease NN cord-258172-p54j4zzo 315 13 is be VBZ cord-258172-p54j4zzo 315 14 linked link VBN cord-258172-p54j4zzo 315 15 to to IN cord-258172-p54j4zzo 315 16 the the DT cord-258172-p54j4zzo 315 17 severe severe JJ cord-258172-p54j4zzo 315 18 acute acute JJ cord-258172-p54j4zzo 315 19 respiratory respiratory JJ cord-258172-p54j4zzo 315 20 syndrome syndrome NN cord-258172-p54j4zzo 315 21 coronavirus coronavirus NN cord-258172-p54j4zzo 315 22 receptor receptor NN cord-258172-p54j4zzo 315 23 and and CC cord-258172-p54j4zzo 315 24 activates activate VBZ cord-258172-p54j4zzo 315 25 virus virus NN cord-258172-p54j4zzo 315 26 entry entry NN cord-258172-p54j4zzo 315 27 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 316 1 and and CC cord-258172-p54j4zzo 316 2 ADAM17 adam17 UH cord-258172-p54j4zzo 316 3 cleave cleave VB cord-258172-p54j4zzo 316 4 ACE2 ACE2 NNP cord-258172-p54j4zzo 316 5 differentially differentially RB cord-258172-p54j4zzo 317 1 and and CC cord-258172-p54j4zzo 317 2 only only JJ cord-258172-p54j4zzo 317 3 proteolysis proteolysis NN cord-258172-p54j4zzo 317 4 by by IN cord-258172-p54j4zzo 317 5 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 317 6 augments augment VBZ cord-258172-p54j4zzo 317 7 entry entry NN cord-258172-p54j4zzo 317 8 driven drive VBN cord-258172-p54j4zzo 317 9 by by IN cord-258172-p54j4zzo 317 10 the the DT cord-258172-p54j4zzo 317 11 severe severe JJ cord-258172-p54j4zzo 317 12 acute acute JJ cord-258172-p54j4zzo 317 13 respiratory respiratory JJ cord-258172-p54j4zzo 317 14 syndrome syndrome NN cord-258172-p54j4zzo 317 15 coronavirus coronavirus NN cord-258172-p54j4zzo 317 16 spike spike NN cord-258172-p54j4zzo 317 17 protein protein NN cord-258172-p54j4zzo 317 18 Structure Structure NNP cord-258172-p54j4zzo 317 19 of of IN cord-258172-p54j4zzo 317 20 SARS SARS NNP cord-258172-p54j4zzo 317 21 coronavirus coronavirus NN cord-258172-p54j4zzo 317 22 spike spike NN cord-258172-p54j4zzo 317 23 receptor receptor NN cord-258172-p54j4zzo 317 24 - - HYPH cord-258172-p54j4zzo 317 25 binding bind VBG cord-258172-p54j4zzo 317 26 domain domain NN cord-258172-p54j4zzo 317 27 complexed complexe VBN cord-258172-p54j4zzo 317 28 with with IN cord-258172-p54j4zzo 317 29 receptor receptor NN cord-258172-p54j4zzo 317 30 Structural structural JJ cord-258172-p54j4zzo 317 31 and and CC cord-258172-p54j4zzo 317 32 functional functional JJ cord-258172-p54j4zzo 317 33 basis basis NN cord-258172-p54j4zzo 317 34 of of IN cord-258172-p54j4zzo 317 35 SARS SARS NNP cord-258172-p54j4zzo 317 36 - - HYPH cord-258172-p54j4zzo 317 37 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 317 38 entry entry NN cord-258172-p54j4zzo 317 39 by by IN cord-258172-p54j4zzo 317 40 using use VBG cord-258172-p54j4zzo 317 41 human human JJ cord-258172-p54j4zzo 317 42 ACE2 ACE2 NNP cord-258172-p54j4zzo 317 43 Structural structural JJ cord-258172-p54j4zzo 317 44 basis basis NN cord-258172-p54j4zzo 317 45 of of IN cord-258172-p54j4zzo 317 46 receptor receptor NN cord-258172-p54j4zzo 317 47 recognition recognition NN cord-258172-p54j4zzo 317 48 by by IN cord-258172-p54j4zzo 317 49 SARS SARS NNP cord-258172-p54j4zzo 317 50 - - HYPH cord-258172-p54j4zzo 317 51 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 317 52 Structure Structure NNP cord-258172-p54j4zzo 317 53 of of IN cord-258172-p54j4zzo 317 54 the the DT cord-258172-p54j4zzo 317 55 SARS SARS NNP cord-258172-p54j4zzo 317 56 - - HYPH cord-258172-p54j4zzo 317 57 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 317 58 spike spike NN cord-258172-p54j4zzo 317 59 receptor receptor NN cord-258172-p54j4zzo 317 60 - - HYPH cord-258172-p54j4zzo 317 61 binding bind VBG cord-258172-p54j4zzo 317 62 domain domain NN cord-258172-p54j4zzo 317 63 bound bind VBN cord-258172-p54j4zzo 317 64 to to IN cord-258172-p54j4zzo 317 65 the the DT cord-258172-p54j4zzo 317 66 ACE2 ACE2 NNP cord-258172-p54j4zzo 317 67 receptor receptor NN cord-258172-p54j4zzo 317 68 Structure Structure NNP cord-258172-p54j4zzo 317 69 , , , cord-258172-p54j4zzo 317 70 Function Function NNP cord-258172-p54j4zzo 317 71 , , , cord-258172-p54j4zzo 317 72 and and CC cord-258172-p54j4zzo 317 73 Antigenicity Antigenicity NNP cord-258172-p54j4zzo 317 74 of of IN cord-258172-p54j4zzo 317 75 the the DT cord-258172-p54j4zzo 317 76 SARS SARS NNP cord-258172-p54j4zzo 317 77 - - HYPH cord-258172-p54j4zzo 317 78 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 317 79 Spike Spike NNP cord-258172-p54j4zzo 317 80 Glycoprotein Glycoprotein NNP cord-258172-p54j4zzo 317 81 Structure Structure NNP cord-258172-p54j4zzo 317 82 analysis analysis NN cord-258172-p54j4zzo 317 83 of of IN cord-258172-p54j4zzo 317 84 the the DT cord-258172-p54j4zzo 317 85 receptor receptor NN cord-258172-p54j4zzo 317 86 binding binding NN cord-258172-p54j4zzo 317 87 of of IN cord-258172-p54j4zzo 317 88 2019-nCoV 2019-ncov CD cord-258172-p54j4zzo 317 89 Clinical clinical JJ cord-258172-p54j4zzo 317 90 Characteristics characteristic NNS cord-258172-p54j4zzo 317 91 of of IN cord-258172-p54j4zzo 317 92 Coronavirus Coronavirus NNP cord-258172-p54j4zzo 317 93 Disease Disease NNP cord-258172-p54j4zzo 317 94 2019 2019 CD cord-258172-p54j4zzo 317 95 in in IN cord-258172-p54j4zzo 317 96 China China NNP cord-258172-p54j4zzo 317 97 Severe severe JJ cord-258172-p54j4zzo 317 98 acute acute JJ cord-258172-p54j4zzo 317 99 respiratory respiratory JJ cord-258172-p54j4zzo 317 100 syndrome syndrome NN cord-258172-p54j4zzo 317 101 coronavirus coronavirus NN cord-258172-p54j4zzo 317 102 2 2 CD cord-258172-p54j4zzo 318 1 ( ( -LRB- cord-258172-p54j4zzo 318 2 SARS SARS NNP cord-258172-p54j4zzo 318 3 - - HYPH cord-258172-p54j4zzo 318 4 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 318 5 ) ) -RRB- cord-258172-p54j4zzo 318 6 and and CC cord-258172-p54j4zzo 318 7 coronavirus coronavirus NN cord-258172-p54j4zzo 318 8 disease-2019 disease-2019 NNP cord-258172-p54j4zzo 318 9 ( ( -LRB- cord-258172-p54j4zzo 318 10 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 318 11 ) ) -RRB- cord-258172-p54j4zzo 318 12 : : : cord-258172-p54j4zzo 319 1 The the DT cord-258172-p54j4zzo 319 2 epidemic epidemic NN cord-258172-p54j4zzo 319 3 and and CC cord-258172-p54j4zzo 319 4 the the DT cord-258172-p54j4zzo 319 5 challenges challenge NNS cord-258172-p54j4zzo 319 6 Epidemiologic Epidemiologic NNP cord-258172-p54j4zzo 319 7 and and CC cord-258172-p54j4zzo 319 8 Clinical Clinical NNP cord-258172-p54j4zzo 319 9 Characteristics characteristic NNS cord-258172-p54j4zzo 319 10 of of IN cord-258172-p54j4zzo 319 11 91 91 CD cord-258172-p54j4zzo 319 12 Hospitalized Hospitalized NNP cord-258172-p54j4zzo 319 13 Patients Patients NNPS cord-258172-p54j4zzo 319 14 with with IN cord-258172-p54j4zzo 319 15 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 319 16 in in IN cord-258172-p54j4zzo 319 17 Zhejiang Zhejiang NNP cord-258172-p54j4zzo 319 18 , , , cord-258172-p54j4zzo 319 19 China China NNP cord-258172-p54j4zzo 319 20 : : : cord-258172-p54j4zzo 319 21 A a DT cord-258172-p54j4zzo 319 22 retrospective retrospective JJ cord-258172-p54j4zzo 319 23 , , , cord-258172-p54j4zzo 319 24 multi multi JJ cord-258172-p54j4zzo 319 25 - - JJ cord-258172-p54j4zzo 319 26 centre centre JJ cord-258172-p54j4zzo 319 27 case case NN cord-258172-p54j4zzo 319 28 series series NN cord-258172-p54j4zzo 319 29 Clinical clinical JJ cord-258172-p54j4zzo 319 30 characteristics characteristic NNS cord-258172-p54j4zzo 319 31 of of IN cord-258172-p54j4zzo 319 32 113 113 CD cord-258172-p54j4zzo 319 33 deceased deceased JJ cord-258172-p54j4zzo 319 34 patients patient NNS cord-258172-p54j4zzo 319 35 with with IN cord-258172-p54j4zzo 319 36 coronavirus coronavirus NN cord-258172-p54j4zzo 319 37 disease disease NN cord-258172-p54j4zzo 319 38 2019 2019 CD cord-258172-p54j4zzo 319 39 : : : cord-258172-p54j4zzo 320 1 retrospective retrospective JJ cord-258172-p54j4zzo 320 2 study study NNP cord-258172-p54j4zzo 321 1 Quantitative quantitative JJ cord-258172-p54j4zzo 321 2 mRNA mRNA NNP cord-258172-p54j4zzo 321 3 expression expression NN cord-258172-p54j4zzo 321 4 profiling profiling NN cord-258172-p54j4zzo 321 5 of of IN cord-258172-p54j4zzo 321 6 ACE ace NN cord-258172-p54j4zzo 321 7 2 2 CD cord-258172-p54j4zzo 321 8 , , , cord-258172-p54j4zzo 321 9 a a DT cord-258172-p54j4zzo 321 10 novel novel JJ cord-258172-p54j4zzo 321 11 homologue homologue NN cord-258172-p54j4zzo 321 12 of of IN cord-258172-p54j4zzo 321 13 angiotensin angiotensin NN cord-258172-p54j4zzo 321 14 converting convert VBG cord-258172-p54j4zzo 321 15 enzyme enzyme NN cord-258172-p54j4zzo 321 16 Tissue tissue NN cord-258172-p54j4zzo 321 17 distribution distribution NN cord-258172-p54j4zzo 321 18 of of IN cord-258172-p54j4zzo 321 19 ACE2 ACE2 NNP cord-258172-p54j4zzo 321 20 protein protein NN cord-258172-p54j4zzo 321 21 , , , cord-258172-p54j4zzo 321 22 the the DT cord-258172-p54j4zzo 321 23 functional functional JJ cord-258172-p54j4zzo 321 24 receptor receptor NN cord-258172-p54j4zzo 321 25 for for IN cord-258172-p54j4zzo 321 26 SARS SARS NNP cord-258172-p54j4zzo 321 27 coronavirus coronavirus NN cord-258172-p54j4zzo 321 28 . . . cord-258172-p54j4zzo 322 1 A a DT cord-258172-p54j4zzo 322 2 first first JJ cord-258172-p54j4zzo 322 3 step step NN cord-258172-p54j4zzo 322 4 in in IN cord-258172-p54j4zzo 322 5 understanding understand VBG cord-258172-p54j4zzo 322 6 SARS SARS NNP cord-258172-p54j4zzo 322 7 pathogenesis pathogenesis NN cord-258172-p54j4zzo 322 8 Organ Organ NNP cord-258172-p54j4zzo 322 9 distribution distribution NN cord-258172-p54j4zzo 322 10 of of IN cord-258172-p54j4zzo 322 11 severe severe JJ cord-258172-p54j4zzo 322 12 acute acute JJ cord-258172-p54j4zzo 322 13 respiratory respiratory JJ cord-258172-p54j4zzo 322 14 syndrome syndrome NN cord-258172-p54j4zzo 322 15 ( ( -LRB- cord-258172-p54j4zzo 322 16 SARS SARS NNP cord-258172-p54j4zzo 322 17 ) ) -RRB- cord-258172-p54j4zzo 322 18 associated associate VBD cord-258172-p54j4zzo 322 19 coronavirus coronavirus NN cord-258172-p54j4zzo 322 20 ( ( -LRB- cord-258172-p54j4zzo 322 21 SARS SARS NNP cord-258172-p54j4zzo 322 22 - - HYPH cord-258172-p54j4zzo 322 23 CoV CoV NNP cord-258172-p54j4zzo 322 24 ) ) -RRB- cord-258172-p54j4zzo 322 25 in in IN cord-258172-p54j4zzo 322 26 SARS SARS NNP cord-258172-p54j4zzo 322 27 patients patient NNS cord-258172-p54j4zzo 322 28 : : : cord-258172-p54j4zzo 322 29 implications implication NNS cord-258172-p54j4zzo 322 30 for for IN cord-258172-p54j4zzo 322 31 pathogenesis pathogenesis NN cord-258172-p54j4zzo 322 32 and and CC cord-258172-p54j4zzo 322 33 virus virus NN cord-258172-p54j4zzo 322 34 transmission transmission NN cord-258172-p54j4zzo 322 35 pathways pathway NNS cord-258172-p54j4zzo 322 36 Exploring explore VBG cord-258172-p54j4zzo 322 37 the the DT cord-258172-p54j4zzo 322 38 pathogenesis pathogenesis NN cord-258172-p54j4zzo 322 39 of of IN cord-258172-p54j4zzo 322 40 severe severe JJ cord-258172-p54j4zzo 322 41 acute acute JJ cord-258172-p54j4zzo 322 42 respiratory respiratory JJ cord-258172-p54j4zzo 322 43 syndrome syndrome NN cord-258172-p54j4zzo 322 44 ( ( -LRB- cord-258172-p54j4zzo 322 45 SARS SARS NNP cord-258172-p54j4zzo 322 46 ) ) -RRB- cord-258172-p54j4zzo 322 47 : : : cord-258172-p54j4zzo 322 48 the the DT cord-258172-p54j4zzo 322 49 tissue tissue NN cord-258172-p54j4zzo 322 50 distribution distribution NN cord-258172-p54j4zzo 322 51 of of IN cord-258172-p54j4zzo 322 52 the the DT cord-258172-p54j4zzo 322 53 coronavirus coronavirus NN cord-258172-p54j4zzo 322 54 ( ( -LRB- cord-258172-p54j4zzo 322 55 SARS SARS NNP cord-258172-p54j4zzo 322 56 - - HYPH cord-258172-p54j4zzo 322 57 CoV CoV NNP cord-258172-p54j4zzo 322 58 ) ) -RRB- cord-258172-p54j4zzo 322 59 and and CC cord-258172-p54j4zzo 322 60 its -PRON- PRP$ cord-258172-p54j4zzo 322 61 putative putative JJ cord-258172-p54j4zzo 322 62 receptor receptor NN cord-258172-p54j4zzo 322 63 The the DT cord-258172-p54j4zzo 322 64 Immunobiology Immunobiology NNP cord-258172-p54j4zzo 322 65 of of IN cord-258172-p54j4zzo 322 66 SARS SARS NNP cord-258172-p54j4zzo 323 1 * * NFP cord-258172-p54j4zzo 323 2 Effect effect NN cord-258172-p54j4zzo 323 3 of of IN cord-258172-p54j4zzo 323 4 gastrointestinal gastrointestinal JJ cord-258172-p54j4zzo 323 5 symptoms symptom NNS cord-258172-p54j4zzo 323 6 in in IN cord-258172-p54j4zzo 323 7 patients patient NNS cord-258172-p54j4zzo 323 8 with with IN cord-258172-p54j4zzo 323 9 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 323 10 Severe severe JJ cord-258172-p54j4zzo 323 11 acute acute JJ cord-258172-p54j4zzo 323 12 respiratory respiratory JJ cord-258172-p54j4zzo 323 13 syndrome syndrome NN cord-258172-p54j4zzo 323 14 coronavirus coronavirus NN cord-258172-p54j4zzo 323 15 infection infection NN cord-258172-p54j4zzo 323 16 of of IN cord-258172-p54j4zzo 323 17 human human JJ cord-258172-p54j4zzo 323 18 ciliated ciliated JJ cord-258172-p54j4zzo 323 19 airway airway NN cord-258172-p54j4zzo 323 20 epithelia epithelium NNS cord-258172-p54j4zzo 323 21 : : : cord-258172-p54j4zzo 323 22 role role NN cord-258172-p54j4zzo 323 23 of of IN cord-258172-p54j4zzo 323 24 ciliated ciliated JJ cord-258172-p54j4zzo 323 25 cells cell NNS cord-258172-p54j4zzo 323 26 in in IN cord-258172-p54j4zzo 323 27 viral viral JJ cord-258172-p54j4zzo 323 28 spread spread NN cord-258172-p54j4zzo 323 29 in in IN cord-258172-p54j4zzo 323 30 the the DT cord-258172-p54j4zzo 323 31 conducting conduct VBG cord-258172-p54j4zzo 323 32 airways airway NNS cord-258172-p54j4zzo 323 33 of of IN cord-258172-p54j4zzo 323 34 the the DT cord-258172-p54j4zzo 323 35 lungs lung NNS cord-258172-p54j4zzo 323 36 Analysis Analysis NNP cord-258172-p54j4zzo 323 37 of of IN cord-258172-p54j4zzo 323 38 ACE2 ACE2 NNP cord-258172-p54j4zzo 323 39 in in IN cord-258172-p54j4zzo 323 40 polarized polarized JJ cord-258172-p54j4zzo 323 41 epithelial epithelial JJ cord-258172-p54j4zzo 323 42 cells cell NNS cord-258172-p54j4zzo 323 43 : : : cord-258172-p54j4zzo 323 44 surface surface NN cord-258172-p54j4zzo 323 45 expression expression NN cord-258172-p54j4zzo 323 46 and and CC cord-258172-p54j4zzo 323 47 function function NN cord-258172-p54j4zzo 323 48 as as IN cord-258172-p54j4zzo 323 49 receptor receptor NN cord-258172-p54j4zzo 323 50 for for IN cord-258172-p54j4zzo 323 51 severe severe JJ cord-258172-p54j4zzo 323 52 acute acute JJ cord-258172-p54j4zzo 323 53 respiratory respiratory JJ cord-258172-p54j4zzo 323 54 syndrome syndrome NN cord-258172-p54j4zzo 323 55 - - HYPH cord-258172-p54j4zzo 323 56 associated associate VBN cord-258172-p54j4zzo 323 57 coronavirus coronavirus NN cord-258172-p54j4zzo 323 58 Asymptomatic asymptomatic JJ cord-258172-p54j4zzo 323 59 carrier carrier NN cord-258172-p54j4zzo 323 60 state state NN cord-258172-p54j4zzo 323 61 , , , cord-258172-p54j4zzo 323 62 acute acute JJ cord-258172-p54j4zzo 323 63 respiratory respiratory JJ cord-258172-p54j4zzo 323 64 disease disease NN cord-258172-p54j4zzo 323 65 , , , cord-258172-p54j4zzo 323 66 and and CC cord-258172-p54j4zzo 323 67 pneumonia pneumonia NN cord-258172-p54j4zzo 323 68 due due JJ cord-258172-p54j4zzo 323 69 to to IN cord-258172-p54j4zzo 323 70 severe severe JJ cord-258172-p54j4zzo 323 71 acute acute JJ cord-258172-p54j4zzo 323 72 respiratory respiratory JJ cord-258172-p54j4zzo 323 73 syndrome syndrome NN cord-258172-p54j4zzo 323 74 coronavirus coronavirus NN cord-258172-p54j4zzo 323 75 2 2 CD cord-258172-p54j4zzo 323 76 ( ( -LRB- cord-258172-p54j4zzo 323 77 SARS SARS NNP cord-258172-p54j4zzo 323 78 - - HYPH cord-258172-p54j4zzo 323 79 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 323 80 ) ) -RRB- cord-258172-p54j4zzo 323 81 : : : cord-258172-p54j4zzo 324 1 Facts fact NNS cord-258172-p54j4zzo 324 2 and and CC cord-258172-p54j4zzo 324 3 myths myth NNS cord-258172-p54j4zzo 324 4 Impact Impact NNP cord-258172-p54j4zzo 324 5 of of IN cord-258172-p54j4zzo 324 6 sex sex NN cord-258172-p54j4zzo 324 7 and and CC cord-258172-p54j4zzo 324 8 gender gender NN cord-258172-p54j4zzo 324 9 on on IN cord-258172-p54j4zzo 324 10 COVID-19 covid-19 JJ cord-258172-p54j4zzo 324 11 outcomes outcome NNS cord-258172-p54j4zzo 324 12 in in IN cord-258172-p54j4zzo 324 13 Europe Europe NNP cord-258172-p54j4zzo 325 1 A a DT cord-258172-p54j4zzo 325 2 promoter promoter NN cord-258172-p54j4zzo 325 3 - - HYPH cord-258172-p54j4zzo 325 4 level level NN cord-258172-p54j4zzo 325 5 mammalian mammalian JJ cord-258172-p54j4zzo 325 6 expression expression NN cord-258172-p54j4zzo 325 7 atlas atlas NNP cord-258172-p54j4zzo 325 8 A A NNP cord-258172-p54j4zzo 325 9 2D 2D NNP cord-258172-p54j4zzo 325 10 Graphics Graphics NNP cord-258172-p54j4zzo 325 11 Environment Environment NNP cord-258172-p54j4zzo 325 12 Human Human NNP cord-258172-p54j4zzo 325 13 genomics genomic NNS cord-258172-p54j4zzo 325 14 . . . cord-258172-p54j4zzo 326 1 The the DT cord-258172-p54j4zzo 326 2 Genotype Genotype NNP cord-258172-p54j4zzo 326 3 - - HYPH cord-258172-p54j4zzo 326 4 Tissue Tissue NNP cord-258172-p54j4zzo 326 5 Expression expression NN cord-258172-p54j4zzo 326 6 ( ( -LRB- cord-258172-p54j4zzo 326 7 GTEx GTEx NNP cord-258172-p54j4zzo 326 8 ) ) -RRB- cord-258172-p54j4zzo 326 9 pilot pilot NN cord-258172-p54j4zzo 326 10 analysis analysis NN cord-258172-p54j4zzo 326 11 : : : cord-258172-p54j4zzo 326 12 multitissue multitissue NNP cord-258172-p54j4zzo 326 13 gene gene NN cord-258172-p54j4zzo 326 14 regulation regulation NN cord-258172-p54j4zzo 326 15 in in IN cord-258172-p54j4zzo 326 16 humans human NNS cord-258172-p54j4zzo 327 1 SciPy SciPy NNP cord-258172-p54j4zzo 327 2 1.0 1.0 CD cord-258172-p54j4zzo 327 3 : : : cord-258172-p54j4zzo 327 4 fundamental fundamental JJ cord-258172-p54j4zzo 327 5 algorithms algorithm NNS cord-258172-p54j4zzo 327 6 for for IN cord-258172-p54j4zzo 327 7 scientific scientific JJ cord-258172-p54j4zzo 327 8 computing computing NN cord-258172-p54j4zzo 327 9 in in IN cord-258172-p54j4zzo 327 10 Python Python NNP cord-258172-p54j4zzo 327 11 Profiler Profiler NNP cord-258172-p54j4zzo 327 12 : : : cord-258172-p54j4zzo 327 13 a a DT cord-258172-p54j4zzo 327 14 web web NN cord-258172-p54j4zzo 327 15 server server NN cord-258172-p54j4zzo 327 16 for for IN cord-258172-p54j4zzo 327 17 functional functional JJ cord-258172-p54j4zzo 327 18 enrichment enrichment NN cord-258172-p54j4zzo 327 19 analysis analysis NN cord-258172-p54j4zzo 327 20 and and CC cord-258172-p54j4zzo 327 21 conversions conversion NNS cord-258172-p54j4zzo 327 22 of of IN cord-258172-p54j4zzo 327 23 gene gene NN cord-258172-p54j4zzo 327 24 lists list NNS cord-258172-p54j4zzo 327 25 ( ( -LRB- cord-258172-p54j4zzo 327 26 2019 2019 CD cord-258172-p54j4zzo 327 27 update update NN cord-258172-p54j4zzo 327 28 ) ) -RRB- cord-258172-p54j4zzo 327 29 Proteomics Proteomics NNP cord-258172-p54j4zzo 327 30 . . . cord-258172-p54j4zzo 328 1 Tissuebased tissuebase VBN cord-258172-p54j4zzo 328 2 map map NN cord-258172-p54j4zzo 328 3 of of IN cord-258172-p54j4zzo 328 4 the the DT cord-258172-p54j4zzo 328 5 human human JJ cord-258172-p54j4zzo 328 6 proteome proteome NN cord-258172-p54j4zzo 329 1 An an DT cord-258172-p54j4zzo 329 2 integrated integrated JJ cord-258172-p54j4zzo 329 3 encyclopedia encyclopedia NN cord-258172-p54j4zzo 329 4 of of IN cord-258172-p54j4zzo 329 5 DNA dna NN cord-258172-p54j4zzo 329 6 elements element NNS cord-258172-p54j4zzo 329 7 in in IN cord-258172-p54j4zzo 329 8 the the DT cord-258172-p54j4zzo 329 9 human human JJ cord-258172-p54j4zzo 329 10 genome genome NN cord-258172-p54j4zzo 329 11 Gateways gateway NNS cord-258172-p54j4zzo 329 12 to to IN cord-258172-p54j4zzo 329 13 the the DT cord-258172-p54j4zzo 329 14 FANTOM5 fantom5 NN cord-258172-p54j4zzo 329 15 promoter promoter NN cord-258172-p54j4zzo 329 16 level level NN cord-258172-p54j4zzo 329 17 mammalian mammalian JJ cord-258172-p54j4zzo 329 18 expression expression NN cord-258172-p54j4zzo 329 19 atlas atlas NNP cord-258172-p54j4zzo 329 20 GTRD GTRD NNP cord-258172-p54j4zzo 329 21 : : : cord-258172-p54j4zzo 329 22 a a DT cord-258172-p54j4zzo 329 23 database database NN cord-258172-p54j4zzo 329 24 of of IN cord-258172-p54j4zzo 329 25 transcription transcription NN cord-258172-p54j4zzo 329 26 factor factor NN cord-258172-p54j4zzo 329 27 binding bind VBG cord-258172-p54j4zzo 329 28 sites site NNS cord-258172-p54j4zzo 329 29 identified identify VBN cord-258172-p54j4zzo 329 30 by by IN cord-258172-p54j4zzo 329 31 ChIP chip NN cord-258172-p54j4zzo 329 32 - - HYPH cord-258172-p54j4zzo 329 33 seq seq NN cord-258172-p54j4zzo 329 34 experiments experiment NNS cord-258172-p54j4zzo 330 1 A a DT cord-258172-p54j4zzo 330 2 new new JJ cord-258172-p54j4zzo 330 3 generation generation NN cord-258172-p54j4zzo 330 4 of of IN cord-258172-p54j4zzo 330 5 JASPAR JASPAR NNP cord-258172-p54j4zzo 330 6 , , , cord-258172-p54j4zzo 330 7 the the DT cord-258172-p54j4zzo 330 8 open open JJ cord-258172-p54j4zzo 330 9 - - HYPH cord-258172-p54j4zzo 330 10 access access NN cord-258172-p54j4zzo 330 11 repository repository NN cord-258172-p54j4zzo 330 12 for for IN cord-258172-p54j4zzo 331 1 transcription transcription NN cord-258172-p54j4zzo 331 2 factor factor NN cord-258172-p54j4zzo 331 3 binding bind VBG cord-258172-p54j4zzo 331 4 site site NN cord-258172-p54j4zzo 331 5 profiles profile NNS cord-258172-p54j4zzo 332 1 Evolution evolution NN cord-258172-p54j4zzo 332 2 is be VBZ cord-258172-p54j4zzo 332 3 in in IN cord-258172-p54j4zzo 332 4 the the DT cord-258172-p54j4zzo 332 5 details detail NNS cord-258172-p54j4zzo 332 6 : : : cord-258172-p54j4zzo 332 7 Regulatory regulatory JJ cord-258172-p54j4zzo 332 8 differences difference NNS cord-258172-p54j4zzo 332 9 in in IN cord-258172-p54j4zzo 332 10 modern modern JJ cord-258172-p54j4zzo 332 11 human human JJ cord-258172-p54j4zzo 332 12 and and CC cord-258172-p54j4zzo 332 13 Neanderthal neanderthal JJ cord-258172-p54j4zzo 333 1 The the DT cord-258172-p54j4zzo 333 2 transcription transcription NN cord-258172-p54j4zzo 333 3 factor factor NN cord-258172-p54j4zzo 333 4 HNF1alpha HNF1alpha NNP cord-258172-p54j4zzo 333 5 induces induce VBZ cord-258172-p54j4zzo 333 6 expression expression NN cord-258172-p54j4zzo 333 7 of of IN cord-258172-p54j4zzo 333 8 angiotensin angiotensin NN cord-258172-p54j4zzo 333 9 - - HYPH cord-258172-p54j4zzo 333 10 converting convert VBG cord-258172-p54j4zzo 333 11 enzyme enzyme NN cord-258172-p54j4zzo 333 12 2 2 CD cord-258172-p54j4zzo 333 13 ( ( -LRB- cord-258172-p54j4zzo 333 14 ACE2 ACE2 NNP cord-258172-p54j4zzo 333 15 ) ) -RRB- cord-258172-p54j4zzo 333 16 in in IN cord-258172-p54j4zzo 333 17 pancreatic pancreatic JJ cord-258172-p54j4zzo 333 18 islets islet NNS cord-258172-p54j4zzo 333 19 from from IN cord-258172-p54j4zzo 334 1 evolutionarily evolutionarily RB cord-258172-p54j4zzo 334 2 conserved conserve VBN cord-258172-p54j4zzo 334 3 promoter promoter NN cord-258172-p54j4zzo 334 4 motifs motif NNS cord-258172-p54j4zzo 334 5 Single Single NNP cord-258172-p54j4zzo 334 6 Cell Cell NNP cord-258172-p54j4zzo 334 7 RNA RNA NNP cord-258172-p54j4zzo 334 8 - - HYPH cord-258172-p54j4zzo 334 9 seq seq NNP cord-258172-p54j4zzo 334 10 reveals reveal VBZ cord-258172-p54j4zzo 334 11 ectopic ectopic JJ cord-258172-p54j4zzo 334 12 and and CC cord-258172-p54j4zzo 334 13 aberrant aberrant JJ cord-258172-p54j4zzo 334 14 lung lung NN cord-258172-p54j4zzo 334 15 - - HYPH cord-258172-p54j4zzo 334 16 resident resident NN cord-258172-p54j4zzo 334 17 cell cell NN cord-258172-p54j4zzo 334 18 populations population NNS cord-258172-p54j4zzo 334 19 in in IN cord-258172-p54j4zzo 334 20 Idiopathic idiopathic JJ cord-258172-p54j4zzo 334 21 pulmonary pulmonary JJ cord-258172-p54j4zzo 334 22 fibrosis fibrosis NN cord-258172-p54j4zzo 335 1 A a DT cord-258172-p54j4zzo 335 2 revised revise VBN cord-258172-p54j4zzo 335 3 airway airway NN cord-258172-p54j4zzo 335 4 epithelial epithelial JJ cord-258172-p54j4zzo 335 5 hierarchy hierarchy NN cord-258172-p54j4zzo 335 6 includes include VBZ cord-258172-p54j4zzo 335 7 CFTR CFTR NNP cord-258172-p54j4zzo 335 8 - - HYPH cord-258172-p54j4zzo 335 9 expressing express VBG cord-258172-p54j4zzo 335 10 ionocytes ionocyte NNS cord-258172-p54j4zzo 336 1 A a DT cord-258172-p54j4zzo 336 2 single single JJ cord-258172-p54j4zzo 336 3 - - HYPH cord-258172-p54j4zzo 336 4 cell cell NN cord-258172-p54j4zzo 336 5 survey survey NN cord-258172-p54j4zzo 336 6 of of IN cord-258172-p54j4zzo 336 7 the the DT cord-258172-p54j4zzo 336 8 small small JJ cord-258172-p54j4zzo 336 9 intestinal intestinal JJ cord-258172-p54j4zzo 336 10 epithelium epithelium NN cord-258172-p54j4zzo 336 11 Current current JJ cord-258172-p54j4zzo 336 12 best good JJS cord-258172-p54j4zzo 336 13 practices practice NNS cord-258172-p54j4zzo 336 14 in in IN cord-258172-p54j4zzo 336 15 single single JJ cord-258172-p54j4zzo 336 16 - - HYPH cord-258172-p54j4zzo 336 17 cell cell NN cord-258172-p54j4zzo 336 18 RNA RNA NNP cord-258172-p54j4zzo 336 19 - - HYPH cord-258172-p54j4zzo 336 20 seq seq NN cord-258172-p54j4zzo 336 21 analysis analysis NN cord-258172-p54j4zzo 336 22 : : : cord-258172-p54j4zzo 336 23 a a DT cord-258172-p54j4zzo 336 24 tutorial tutorial NN cord-258172-p54j4zzo 336 25 SCANPY SCANPY NNP cord-258172-p54j4zzo 336 26 : : : cord-258172-p54j4zzo 336 27 large large JJ cord-258172-p54j4zzo 336 28 - - HYPH cord-258172-p54j4zzo 336 29 scale scale NN cord-258172-p54j4zzo 336 30 single single JJ cord-258172-p54j4zzo 336 31 - - HYPH cord-258172-p54j4zzo 336 32 cell cell NN cord-258172-p54j4zzo 336 33 gene gene NN cord-258172-p54j4zzo 336 34 expression expression NN cord-258172-p54j4zzo 336 35 data data NN cord-258172-p54j4zzo 336 36 analysis analysis NN cord-258172-p54j4zzo 336 37 Pooling pool VBG cord-258172-p54j4zzo 336 38 across across IN cord-258172-p54j4zzo 336 39 cells cell NNS cord-258172-p54j4zzo 336 40 to to TO cord-258172-p54j4zzo 336 41 normalize normalize VB cord-258172-p54j4zzo 336 42 single single JJ cord-258172-p54j4zzo 336 43 - - HYPH cord-258172-p54j4zzo 336 44 cell cell NN cord-258172-p54j4zzo 336 45 RNA rna NN cord-258172-p54j4zzo 336 46 sequencing sequencing NN cord-258172-p54j4zzo 336 47 data datum NNS cord-258172-p54j4zzo 336 48 with with IN cord-258172-p54j4zzo 336 49 many many JJ cord-258172-p54j4zzo 336 50 zero zero CD cord-258172-p54j4zzo 336 51 counts count VBZ cord-258172-p54j4zzo 336 52 Tissue tissue NN cord-258172-p54j4zzo 336 53 - - HYPH cord-258172-p54j4zzo 336 54 specific specific JJ cord-258172-p54j4zzo 336 55 and and CC cord-258172-p54j4zzo 336 56 interferon interferon NN cord-258172-p54j4zzo 336 57 - - HYPH cord-258172-p54j4zzo 336 58 inducible inducible JJ cord-258172-p54j4zzo 336 59 expression expression NN cord-258172-p54j4zzo 336 60 of of IN cord-258172-p54j4zzo 336 61 non non JJ cord-258172-p54j4zzo 336 62 - - JJ cord-258172-p54j4zzo 336 63 functional functional JJ cord-258172-p54j4zzo 336 64 ACE2 ACE2 NNP cord-258172-p54j4zzo 336 65 through through IN cord-258172-p54j4zzo 336 66 endogenous endogenous JJ cord-258172-p54j4zzo 336 67 retrovirus retrovirus NN cord-258172-p54j4zzo 336 68 co co NN cord-258172-p54j4zzo 336 69 - - NN cord-258172-p54j4zzo 336 70 option option NN cord-258172-p54j4zzo 336 71 Interferons interferon NNS cord-258172-p54j4zzo 336 72 and and CC cord-258172-p54j4zzo 336 73 viruses virus NNS cord-258172-p54j4zzo 337 1 induce induce VB cord-258172-p54j4zzo 337 2 a a DT cord-258172-p54j4zzo 337 3 novel novel JJ cord-258172-p54j4zzo 337 4 primate primate NN cord-258172-p54j4zzo 337 5 - - HYPH cord-258172-p54j4zzo 337 6 specific specific JJ cord-258172-p54j4zzo 337 7 isoform isoform NN cord-258172-p54j4zzo 337 8 dACE2 dace2 NN cord-258172-p54j4zzo 338 1 and and CC cord-258172-p54j4zzo 338 2 not not RB cord-258172-p54j4zzo 338 3 the the DT cord-258172-p54j4zzo 338 4 SARS SARS NNP cord-258172-p54j4zzo 338 5 - - HYPH cord-258172-p54j4zzo 338 6 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 338 7 receptor receptor NN cord-258172-p54j4zzo 338 8 ACE2 ACE2 NNP cord-258172-p54j4zzo 339 1 A a DT cord-258172-p54j4zzo 339 2 novel novel JJ cord-258172-p54j4zzo 339 3 isoform isoform NN cord-258172-p54j4zzo 339 4 of of IN cord-258172-p54j4zzo 339 5 ACE2 ACE2 NNP cord-258172-p54j4zzo 339 6 is be VBZ cord-258172-p54j4zzo 339 7 expressed express VBN cord-258172-p54j4zzo 339 8 in in IN cord-258172-p54j4zzo 339 9 human human JJ cord-258172-p54j4zzo 339 10 nasal nasal NN cord-258172-p54j4zzo 339 11 and and CC cord-258172-p54j4zzo 339 12 bronchial bronchial JJ cord-258172-p54j4zzo 339 13 respiratory respiratory JJ cord-258172-p54j4zzo 339 14 epithelia epithelium NNS cord-258172-p54j4zzo 339 15 and and CC cord-258172-p54j4zzo 339 16 is be VBZ cord-258172-p54j4zzo 339 17 upregulated upregulate VBN cord-258172-p54j4zzo 339 18 in in IN cord-258172-p54j4zzo 339 19 response response NN cord-258172-p54j4zzo 339 20 to to IN cord-258172-p54j4zzo 339 21 RNA RNA NNP cord-258172-p54j4zzo 339 22 respiratory respiratory JJ cord-258172-p54j4zzo 339 23 virus virus NN cord-258172-p54j4zzo 339 24 infection infection NN cord-258172-p54j4zzo 340 1 The the DT cord-258172-p54j4zzo 340 2 spectrum spectrum NN cord-258172-p54j4zzo 340 3 of of IN cord-258172-p54j4zzo 340 4 pathological pathological JJ cord-258172-p54j4zzo 340 5 changes change NNS cord-258172-p54j4zzo 340 6 in in IN cord-258172-p54j4zzo 340 7 severe severe JJ cord-258172-p54j4zzo 340 8 acute acute JJ cord-258172-p54j4zzo 340 9 respiratory respiratory JJ cord-258172-p54j4zzo 340 10 syndrome syndrome NN cord-258172-p54j4zzo 340 11 ( ( -LRB- cord-258172-p54j4zzo 340 12 SARS SARS NNP cord-258172-p54j4zzo 340 13 ) ) -RRB- cord-258172-p54j4zzo 341 1 A a DT cord-258172-p54j4zzo 341 2 novel novel JJ cord-258172-p54j4zzo 341 3 coronavirus coronavirus NN cord-258172-p54j4zzo 341 4 associated associate VBN cord-258172-p54j4zzo 341 5 with with IN cord-258172-p54j4zzo 341 6 severe severe JJ cord-258172-p54j4zzo 341 7 acute acute JJ cord-258172-p54j4zzo 341 8 respiratory respiratory JJ cord-258172-p54j4zzo 341 9 syndrome syndrome NN cord-258172-p54j4zzo 341 10 Newly newly RB cord-258172-p54j4zzo 341 11 discovered discover VBD cord-258172-p54j4zzo 341 12 coronavirus coronavirus NN cord-258172-p54j4zzo 341 13 as as IN cord-258172-p54j4zzo 341 14 the the DT cord-258172-p54j4zzo 341 15 primary primary JJ cord-258172-p54j4zzo 341 16 cause cause NN cord-258172-p54j4zzo 341 17 of of IN cord-258172-p54j4zzo 341 18 severe severe JJ cord-258172-p54j4zzo 341 19 acute acute JJ cord-258172-p54j4zzo 341 20 respiratory respiratory JJ cord-258172-p54j4zzo 341 21 syndrome syndrome NN cord-258172-p54j4zzo 341 22 Tissue tissue NN cord-258172-p54j4zzo 341 23 and and CC cord-258172-p54j4zzo 341 24 cellular cellular JJ cord-258172-p54j4zzo 341 25 tropism tropism NN cord-258172-p54j4zzo 341 26 of of IN cord-258172-p54j4zzo 341 27 the the DT cord-258172-p54j4zzo 341 28 coronavirus coronavirus NN cord-258172-p54j4zzo 341 29 associated associate VBN cord-258172-p54j4zzo 341 30 with with IN cord-258172-p54j4zzo 341 31 severe severe JJ cord-258172-p54j4zzo 341 32 acute acute JJ cord-258172-p54j4zzo 341 33 respiratory respiratory JJ cord-258172-p54j4zzo 341 34 syndrome syndrome NN cord-258172-p54j4zzo 341 35 : : : cord-258172-p54j4zzo 341 36 an an DT cord-258172-p54j4zzo 341 37 in in IN cord-258172-p54j4zzo 341 38 - - HYPH cord-258172-p54j4zzo 341 39 situ situ NN cord-258172-p54j4zzo 341 40 hybridization hybridization NN cord-258172-p54j4zzo 341 41 study study NN cord-258172-p54j4zzo 341 42 of of IN cord-258172-p54j4zzo 341 43 fatal fatal JJ cord-258172-p54j4zzo 341 44 cases case NNS cord-258172-p54j4zzo 341 45 Detection detection NN cord-258172-p54j4zzo 341 46 of of IN cord-258172-p54j4zzo 341 47 severe severe JJ cord-258172-p54j4zzo 341 48 acute acute JJ cord-258172-p54j4zzo 341 49 respiratory respiratory JJ cord-258172-p54j4zzo 341 50 syndromeassociated syndromeassociate VBN cord-258172-p54j4zzo 341 51 coronavirus coronavirus NN cord-258172-p54j4zzo 341 52 in in IN cord-258172-p54j4zzo 341 53 pneumocytes pneumocyte NNS cord-258172-p54j4zzo 341 54 of of IN cord-258172-p54j4zzo 341 55 the the DT cord-258172-p54j4zzo 341 56 lung lung NN cord-258172-p54j4zzo 341 57 SARS SARS NNP cord-258172-p54j4zzo 341 58 - - HYPH cord-258172-p54j4zzo 341 59 CoV CoV NNP cord-258172-p54j4zzo 341 60 replicates replicate NNS cord-258172-p54j4zzo 341 61 in in IN cord-258172-p54j4zzo 341 62 primary primary JJ cord-258172-p54j4zzo 341 63 human human JJ cord-258172-p54j4zzo 341 64 alveolar alveolar NN cord-258172-p54j4zzo 341 65 type type NN cord-258172-p54j4zzo 341 66 II II NNP cord-258172-p54j4zzo 341 67 cell cell NN cord-258172-p54j4zzo 341 68 cultures culture NNS cord-258172-p54j4zzo 341 69 but but CC cord-258172-p54j4zzo 341 70 not not RB cord-258172-p54j4zzo 341 71 in in IN cord-258172-p54j4zzo 341 72 type type NN cord-258172-p54j4zzo 341 73 I i NN cord-258172-p54j4zzo 341 74 - - HYPH cord-258172-p54j4zzo 341 75 like like JJ cord-258172-p54j4zzo 341 76 cells cell NNS cord-258172-p54j4zzo 341 77 SARS SARS NNP cord-258172-p54j4zzo 341 78 - - HYPH cord-258172-p54j4zzo 341 79 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 341 80 receptor receptor NN cord-258172-p54j4zzo 341 81 ACE2 ACE2 NNP cord-258172-p54j4zzo 341 82 and and CC cord-258172-p54j4zzo 341 83 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 341 84 are be VBP cord-258172-p54j4zzo 341 85 primarily primarily RB cord-258172-p54j4zzo 341 86 expressed express VBN cord-258172-p54j4zzo 341 87 in in IN cord-258172-p54j4zzo 341 88 bronchial bronchial JJ cord-258172-p54j4zzo 341 89 transient transient JJ cord-258172-p54j4zzo 341 90 secretory secretory NN cord-258172-p54j4zzo 341 91 cells cell NNS cord-258172-p54j4zzo 341 92 Single single JJ cord-258172-p54j4zzo 341 93 - - HYPH cord-258172-p54j4zzo 341 94 cell cell NN cord-258172-p54j4zzo 341 95 RNA rna NN cord-258172-p54j4zzo 341 96 analysis analysis NN cord-258172-p54j4zzo 341 97 on on IN cord-258172-p54j4zzo 341 98 ACE2 ACE2 NNP cord-258172-p54j4zzo 341 99 expression expression NN cord-258172-p54j4zzo 341 100 provides provide VBZ cord-258172-p54j4zzo 341 101 insights insight NNS cord-258172-p54j4zzo 341 102 into into IN cord-258172-p54j4zzo 341 103 SARS SARS NNP cord-258172-p54j4zzo 341 104 - - HYPH cord-258172-p54j4zzo 341 105 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 341 106 potential potential JJ cord-258172-p54j4zzo 341 107 entry entry NN cord-258172-p54j4zzo 341 108 into into IN cord-258172-p54j4zzo 341 109 the the DT cord-258172-p54j4zzo 341 110 bloodstream bloodstream NN cord-258172-p54j4zzo 341 111 and and CC cord-258172-p54j4zzo 341 112 heart heart NN cord-258172-p54j4zzo 341 113 injury injury NN cord-258172-p54j4zzo 342 1 Single single JJ cord-258172-p54j4zzo 342 2 cell cell NN cord-258172-p54j4zzo 342 3 RNA rna NN cord-258172-p54j4zzo 342 4 sequencing sequencing NN cord-258172-p54j4zzo 342 5 of of IN cord-258172-p54j4zzo 342 6 13 13 CD cord-258172-p54j4zzo 342 7 human human JJ cord-258172-p54j4zzo 342 8 tissues tissue NNS cord-258172-p54j4zzo 342 9 identify identify VB cord-258172-p54j4zzo 342 10 cell cell NN cord-258172-p54j4zzo 342 11 types type NNS cord-258172-p54j4zzo 342 12 and and CC cord-258172-p54j4zzo 342 13 receptors receptor NNS cord-258172-p54j4zzo 342 14 of of IN cord-258172-p54j4zzo 342 15 human human JJ cord-258172-p54j4zzo 342 16 coronaviruses coronaviruse NNS cord-258172-p54j4zzo 342 17 Single single JJ cord-258172-p54j4zzo 342 18 - - HYPH cord-258172-p54j4zzo 342 19 cell cell NN cord-258172-p54j4zzo 342 20 RNA RNA NNP cord-258172-p54j4zzo 342 21 - - HYPH cord-258172-p54j4zzo 342 22 seq seq NNP cord-258172-p54j4zzo 342 23 data data NN cord-258172-p54j4zzo 342 24 analysis analysis NN cord-258172-p54j4zzo 342 25 on on IN cord-258172-p54j4zzo 342 26 the the DT cord-258172-p54j4zzo 342 27 receptor receptor NN cord-258172-p54j4zzo 342 28 ACE2 ACE2 NNP cord-258172-p54j4zzo 342 29 expression expression NN cord-258172-p54j4zzo 342 30 reveals reveal VBZ cord-258172-p54j4zzo 342 31 the the DT cord-258172-p54j4zzo 342 32 potential potential JJ cord-258172-p54j4zzo 342 33 risk risk NN cord-258172-p54j4zzo 342 34 of of IN cord-258172-p54j4zzo 342 35 different different JJ cord-258172-p54j4zzo 342 36 human human JJ cord-258172-p54j4zzo 342 37 organs organ NNS cord-258172-p54j4zzo 342 38 vulnerable vulnerable JJ cord-258172-p54j4zzo 342 39 to to IN cord-258172-p54j4zzo 342 40 2019-nCoV 2019-ncov CD cord-258172-p54j4zzo 342 41 infection infection NN cord-258172-p54j4zzo 343 1 Angiotensin angiotensin NN cord-258172-p54j4zzo 343 2 converting convert VBG cord-258172-p54j4zzo 343 3 enzyme enzyme NN cord-258172-p54j4zzo 343 4 2 2 CD cord-258172-p54j4zzo 343 5 is be VBZ cord-258172-p54j4zzo 343 6 primarily primarily RB cord-258172-p54j4zzo 343 7 epithelial epithelial JJ cord-258172-p54j4zzo 343 8 and and CC cord-258172-p54j4zzo 343 9 is be VBZ cord-258172-p54j4zzo 343 10 developmentally developmentally RB cord-258172-p54j4zzo 343 11 regulated regulate VBN cord-258172-p54j4zzo 343 12 in in IN cord-258172-p54j4zzo 343 13 the the DT cord-258172-p54j4zzo 343 14 mouse mouse NN cord-258172-p54j4zzo 343 15 lung lung NN cord-258172-p54j4zzo 343 16 Radiological radiological JJ cord-258172-p54j4zzo 343 17 findings finding NNS cord-258172-p54j4zzo 343 18 from from IN cord-258172-p54j4zzo 343 19 81 81 CD cord-258172-p54j4zzo 343 20 patients patient NNS cord-258172-p54j4zzo 343 21 with with IN cord-258172-p54j4zzo 344 1 COVID-19 covid-19 JJ cord-258172-p54j4zzo 344 2 pneumonia pneumonia NN cord-258172-p54j4zzo 344 3 in in IN cord-258172-p54j4zzo 344 4 Wuhan Wuhan NNP cord-258172-p54j4zzo 344 5 , , , cord-258172-p54j4zzo 344 6 China China NNP cord-258172-p54j4zzo 344 7 : : : cord-258172-p54j4zzo 344 8 a a DT cord-258172-p54j4zzo 344 9 descriptive descriptive JJ cord-258172-p54j4zzo 344 10 study study NN cord-258172-p54j4zzo 344 11 Lung Lung NNP cord-258172-p54j4zzo 344 12 pathology pathology NN cord-258172-p54j4zzo 344 13 of of IN cord-258172-p54j4zzo 344 14 severe severe JJ cord-258172-p54j4zzo 344 15 acute acute JJ cord-258172-p54j4zzo 344 16 respiratory respiratory JJ cord-258172-p54j4zzo 344 17 syndrome syndrome NN cord-258172-p54j4zzo 344 18 ( ( -LRB- cord-258172-p54j4zzo 344 19 SARS SARS NNP cord-258172-p54j4zzo 344 20 ) ) -RRB- cord-258172-p54j4zzo 344 21 : : : cord-258172-p54j4zzo 344 22 a a DT cord-258172-p54j4zzo 344 23 study study NN cord-258172-p54j4zzo 344 24 of of IN cord-258172-p54j4zzo 344 25 8 8 CD cord-258172-p54j4zzo 344 26 autopsy autopsy JJ cord-258172-p54j4zzo 344 27 cases case NNS cord-258172-p54j4zzo 344 28 from from IN cord-258172-p54j4zzo 344 29 Singapore Singapore NNP cord-258172-p54j4zzo 344 30 Lung Lung NNP cord-258172-p54j4zzo 344 31 pathology pathology NN cord-258172-p54j4zzo 344 32 of of IN cord-258172-p54j4zzo 345 1 fatal fatal JJ cord-258172-p54j4zzo 345 2 severe severe JJ cord-258172-p54j4zzo 345 3 acute acute JJ cord-258172-p54j4zzo 345 4 respiratory respiratory JJ cord-258172-p54j4zzo 345 5 syndrome syndrome NN cord-258172-p54j4zzo 345 6 Integrated integrate VBN cord-258172-p54j4zzo 345 7 analyses analysis NNS cord-258172-p54j4zzo 345 8 of of IN cord-258172-p54j4zzo 345 9 single single JJ cord-258172-p54j4zzo 345 10 - - HYPH cord-258172-p54j4zzo 345 11 cell cell NN cord-258172-p54j4zzo 345 12 atlases atlas NNS cord-258172-p54j4zzo 345 13 reveal reveal VBP cord-258172-p54j4zzo 345 14 age age NN cord-258172-p54j4zzo 345 15 , , , cord-258172-p54j4zzo 345 16 gender gender NN cord-258172-p54j4zzo 345 17 , , , cord-258172-p54j4zzo 345 18 and and CC cord-258172-p54j4zzo 345 19 smoking smoking NN cord-258172-p54j4zzo 345 20 status status NN cord-258172-p54j4zzo 345 21 associations association NNS cord-258172-p54j4zzo 345 22 with with IN cord-258172-p54j4zzo 345 23 cell cell NN cord-258172-p54j4zzo 345 24 type type NN cord-258172-p54j4zzo 345 25 - - HYPH cord-258172-p54j4zzo 345 26 specific specific JJ cord-258172-p54j4zzo 345 27 expression expression NN cord-258172-p54j4zzo 345 28 of of IN cord-258172-p54j4zzo 345 29 mediators mediator NNS cord-258172-p54j4zzo 345 30 of of IN cord-258172-p54j4zzo 345 31 SARS SARS NNP cord-258172-p54j4zzo 345 32 - - HYPH cord-258172-p54j4zzo 345 33 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 345 34 viral viral JJ cord-258172-p54j4zzo 345 35 entry entry NN cord-258172-p54j4zzo 345 36 and and CC cord-258172-p54j4zzo 345 37 highlights highlight VBZ cord-258172-p54j4zzo 345 38 inflammatory inflammatory JJ cord-258172-p54j4zzo 345 39 programs program NNS cord-258172-p54j4zzo 345 40 in in IN cord-258172-p54j4zzo 345 41 putative putative JJ cord-258172-p54j4zzo 345 42 target target NN cord-258172-p54j4zzo 345 43 cells cell NNS cord-258172-p54j4zzo 345 44 Nasal Nasal NNP cord-258172-p54j4zzo 345 45 Gene Gene NNP cord-258172-p54j4zzo 345 46 Expression Expression NNP cord-258172-p54j4zzo 345 47 of of IN cord-258172-p54j4zzo 345 48 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 345 49 - - HYPH cord-258172-p54j4zzo 345 50 Converting convert VBG cord-258172-p54j4zzo 345 51 Enzyme Enzyme NNP cord-258172-p54j4zzo 345 52 2 2 CD cord-258172-p54j4zzo 345 53 in in IN cord-258172-p54j4zzo 345 54 Children Children NNPS cord-258172-p54j4zzo 345 55 and and CC cord-258172-p54j4zzo 345 56 Adults Adults NNPS cord-258172-p54j4zzo 346 1 Forkhead Forkhead NNP cord-258172-p54j4zzo 346 2 Box Box NNP cord-258172-p54j4zzo 346 3 Transcription Transcription NNP cord-258172-p54j4zzo 346 4 Factors Factors NNPS cord-258172-p54j4zzo 346 5 of of IN cord-258172-p54j4zzo 346 6 the the DT cord-258172-p54j4zzo 346 7 FOXA FOXA NNP cord-258172-p54j4zzo 346 8 Class Class NNP cord-258172-p54j4zzo 346 9 Are be VBP cord-258172-p54j4zzo 346 10 Required require VBN cord-258172-p54j4zzo 346 11 for for IN cord-258172-p54j4zzo 346 12 Basal Basal NNP cord-258172-p54j4zzo 346 13 Transcription Transcription NNP cord-258172-p54j4zzo 346 14 of of IN cord-258172-p54j4zzo 346 15 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 346 16 - - HYPH cord-258172-p54j4zzo 346 17 Converting convert VBG cord-258172-p54j4zzo 346 18 Enzyme Enzyme NNP cord-258172-p54j4zzo 346 19 2 2 CD cord-258172-p54j4zzo 346 20 Role role NN cord-258172-p54j4zzo 346 21 of of IN cord-258172-p54j4zzo 346 22 HIF-1alpha hif-1alpha NN cord-258172-p54j4zzo 346 23 in in IN cord-258172-p54j4zzo 346 24 the the DT cord-258172-p54j4zzo 346 25 regulation regulation NN cord-258172-p54j4zzo 346 26 ACE ACE NNP cord-258172-p54j4zzo 346 27 and and CC cord-258172-p54j4zzo 346 28 ACE2 ACE2 NNP cord-258172-p54j4zzo 346 29 expression expression NN cord-258172-p54j4zzo 346 30 in in IN cord-258172-p54j4zzo 346 31 hypoxic hypoxic JJ cord-258172-p54j4zzo 346 32 human human JJ cord-258172-p54j4zzo 346 33 pulmonary pulmonary JJ cord-258172-p54j4zzo 346 34 artery artery NN cord-258172-p54j4zzo 346 35 smooth smooth JJ cord-258172-p54j4zzo 346 36 muscle muscle NN cord-258172-p54j4zzo 346 37 cells cell NNS cord-258172-p54j4zzo 346 38 Transcription transcription NN cord-258172-p54j4zzo 346 39 factor factor NN cord-258172-p54j4zzo 346 40 HIF1A HIF1A NNS cord-258172-p54j4zzo 346 41 : : : cord-258172-p54j4zzo 346 42 downstream downstream JJ cord-258172-p54j4zzo 346 43 targets target NNS cord-258172-p54j4zzo 346 44 , , , cord-258172-p54j4zzo 346 45 associated associated JJ cord-258172-p54j4zzo 346 46 pathways pathway NNS cord-258172-p54j4zzo 346 47 , , , cord-258172-p54j4zzo 346 48 polymorphic polymorphic JJ cord-258172-p54j4zzo 346 49 hypoxia hypoxia NN cord-258172-p54j4zzo 346 50 response response NN cord-258172-p54j4zzo 346 51 element element NN cord-258172-p54j4zzo 346 52 ( ( -LRB- cord-258172-p54j4zzo 346 53 HRE HRE NNP cord-258172-p54j4zzo 346 54 ) ) -RRB- cord-258172-p54j4zzo 346 55 sites site NNS cord-258172-p54j4zzo 346 56 , , , cord-258172-p54j4zzo 346 57 and and CC cord-258172-p54j4zzo 346 58 initiative initiative NN cord-258172-p54j4zzo 346 59 for for IN cord-258172-p54j4zzo 346 60 standardization standardization NN cord-258172-p54j4zzo 346 61 of of IN cord-258172-p54j4zzo 346 62 reporting report VBG cord-258172-p54j4zzo 346 63 in in IN cord-258172-p54j4zzo 346 64 scientific scientific JJ cord-258172-p54j4zzo 346 65 literature literature NN cord-258172-p54j4zzo 346 66 Hnf-1beta hnf-1beta ADD cord-258172-p54j4zzo 346 67 transcription transcription NN cord-258172-p54j4zzo 346 68 factor factor NN cord-258172-p54j4zzo 346 69 is be VBZ cord-258172-p54j4zzo 346 70 an an DT cord-258172-p54j4zzo 346 71 early early JJ cord-258172-p54j4zzo 346 72 hif-1alpha hif-1alpha JJ cord-258172-p54j4zzo 346 73 - - HYPH cord-258172-p54j4zzo 346 74 independent independent JJ cord-258172-p54j4zzo 346 75 marker marker NN cord-258172-p54j4zzo 346 76 of of IN cord-258172-p54j4zzo 346 77 epithelial epithelial JJ cord-258172-p54j4zzo 346 78 hypoxia hypoxia NN cord-258172-p54j4zzo 346 79 and and CC cord-258172-p54j4zzo 346 80 controls control VBZ cord-258172-p54j4zzo 346 81 renal renal JJ cord-258172-p54j4zzo 346 82 repair repair NNP cord-258172-p54j4zzo 346 83 O2 O2 NNP cord-258172-p54j4zzo 346 84 regulates regulate VBZ cord-258172-p54j4zzo 346 85 stem stem NN cord-258172-p54j4zzo 346 86 cells cell NNS cord-258172-p54j4zzo 346 87 through through IN cord-258172-p54j4zzo 346 88 Wnt Wnt NNP cord-258172-p54j4zzo 346 89 / / SYM cord-258172-p54j4zzo 346 90 beta beta NN cord-258172-p54j4zzo 346 91 - - HYPH cord-258172-p54j4zzo 346 92 catenin catenin NNS cord-258172-p54j4zzo 347 1 signalling signal VBG cord-258172-p54j4zzo 347 2 SARS SARS NNP cord-258172-p54j4zzo 347 3 - - HYPH cord-258172-p54j4zzo 347 4 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 347 5 Receptor Receptor NNP cord-258172-p54j4zzo 347 6 ACE2 ACE2 NNP cord-258172-p54j4zzo 347 7 Is be VBZ cord-258172-p54j4zzo 347 8 an an DT cord-258172-p54j4zzo 347 9 Interferon Interferon NNP cord-258172-p54j4zzo 347 10 - - HYPH cord-258172-p54j4zzo 347 11 Stimulated stimulate VBN cord-258172-p54j4zzo 347 12 Gene Gene NNP cord-258172-p54j4zzo 347 13 in in IN cord-258172-p54j4zzo 347 14 Human Human NNP cord-258172-p54j4zzo 347 15 Airway Airway NNP cord-258172-p54j4zzo 347 16 Epithelial Epithelial NNP cord-258172-p54j4zzo 347 17 Cells cell NNS cord-258172-p54j4zzo 347 18 and and CC cord-258172-p54j4zzo 347 19 Is be VBZ cord-258172-p54j4zzo 347 20 Detected detect VBN cord-258172-p54j4zzo 347 21 in in IN cord-258172-p54j4zzo 347 22 Specific specific JJ cord-258172-p54j4zzo 347 23 Cell cell NN cord-258172-p54j4zzo 347 24 Subsets subset NNS cord-258172-p54j4zzo 347 25 across across IN cord-258172-p54j4zzo 347 26 Tissues Tissues NNPS cord-258172-p54j4zzo 347 27 ACE2 ACE2 NNP cord-258172-p54j4zzo 347 28 and and CC cord-258172-p54j4zzo 347 29 TMPRSS2 TMPRSS2 NNP cord-258172-p54j4zzo 347 30 expression expression NN cord-258172-p54j4zzo 347 31 by by IN cord-258172-p54j4zzo 347 32 clinical clinical JJ cord-258172-p54j4zzo 347 33 , , , cord-258172-p54j4zzo 347 34 HLA HLA NNP cord-258172-p54j4zzo 347 35 , , , cord-258172-p54j4zzo 347 36 immune immune JJ cord-258172-p54j4zzo 347 37 , , , cord-258172-p54j4zzo 347 38 and and CC cord-258172-p54j4zzo 347 39 microbial microbial JJ cord-258172-p54j4zzo 347 40 correlates correlate VBZ cord-258172-p54j4zzo 347 41 across across IN cord-258172-p54j4zzo 347 42 34 34 CD cord-258172-p54j4zzo 347 43 human human JJ cord-258172-p54j4zzo 347 44 cancers cancer NNS cord-258172-p54j4zzo 347 45 and and CC cord-258172-p54j4zzo 347 46 matched match VBD cord-258172-p54j4zzo 347 47 normal normal JJ cord-258172-p54j4zzo 347 48 tissues tissue NNS cord-258172-p54j4zzo 347 49 : : : cord-258172-p54j4zzo 347 50 implications implication NNS cord-258172-p54j4zzo 347 51 for for IN cord-258172-p54j4zzo 347 52 SARS SARS NNP cord-258172-p54j4zzo 347 53 - - HYPH cord-258172-p54j4zzo 347 54 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 348 1 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 348 2 Auto Auto NNP cord-258172-p54j4zzo 348 3 - - HYPH cord-258172-p54j4zzo 348 4 antibodies antibody NNS cord-258172-p54j4zzo 348 5 against against IN cord-258172-p54j4zzo 348 6 type type NN cord-258172-p54j4zzo 349 1 I -PRON- PRP cord-258172-p54j4zzo 349 2 IFNs ifns VBP cord-258172-p54j4zzo 349 3 in in IN cord-258172-p54j4zzo 349 4 patients patient NNS cord-258172-p54j4zzo 349 5 with with IN cord-258172-p54j4zzo 349 6 life life NN cord-258172-p54j4zzo 349 7 - - HYPH cord-258172-p54j4zzo 349 8 threatening threaten VBG cord-258172-p54j4zzo 349 9 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 349 10 SARS SARS NNP cord-258172-p54j4zzo 349 11 - - HYPH cord-258172-p54j4zzo 349 12 CoV-2 CoV-2 NNP cord-258172-p54j4zzo 349 13 contributes contribute VBZ cord-258172-p54j4zzo 349 14 to to IN cord-258172-p54j4zzo 349 15 altering alter VBG cord-258172-p54j4zzo 349 16 the the DT cord-258172-p54j4zzo 349 17 posttranscriptional posttranscriptional JJ cord-258172-p54j4zzo 349 18 regulatory regulatory JJ cord-258172-p54j4zzo 349 19 networks network NNS cord-258172-p54j4zzo 349 20 across across IN cord-258172-p54j4zzo 349 21 human human JJ cord-258172-p54j4zzo 349 22 tissues tissue NNS cord-258172-p54j4zzo 349 23 by by IN cord-258172-p54j4zzo 349 24 sponging sponge VBG cord-258172-p54j4zzo 349 25 RNA RNA NNP cord-258172-p54j4zzo 349 26 binding bind VBG cord-258172-p54j4zzo 349 27 proteins protein NNS cord-258172-p54j4zzo 349 28 and and CC cord-258172-p54j4zzo 349 29 micro micro NNS cord-258172-p54j4zzo 349 30 - - NNS cord-258172-p54j4zzo 349 31 RNAs rna NNS cord-258172-p54j4zzo 350 1 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 350 2 and and CC cord-258172-p54j4zzo 350 3 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 350 4 - - HYPH cord-258172-p54j4zzo 350 5 Converting converting NN cord-258172-p54j4zzo 351 1 Enzyme Enzyme NNP cord-258172-p54j4zzo 351 2 Inhibitors Inhibitors NNP cord-258172-p54j4zzo 351 3 and and CC cord-258172-p54j4zzo 351 4 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 351 5 Receptor Receptor NNP cord-258172-p54j4zzo 351 6 Blockers Blockers NNP cord-258172-p54j4zzo 352 1 : : : cord-258172-p54j4zzo 352 2 What what WP cord-258172-p54j4zzo 352 3 Is be VBZ cord-258172-p54j4zzo 352 4 the the DT cord-258172-p54j4zzo 352 5 Evidence evidence NN cord-258172-p54j4zzo 352 6 ? ? . cord-258172-p54j4zzo 353 1 JAMA JAMA NNP cord-258172-p54j4zzo 353 2 . . . cord-258172-p54j4zzo 354 1 2020 2020 CD cord-258172-p54j4zzo 354 2 : : : cord-258172-p54j4zzo 354 3 in in IN cord-258172-p54j4zzo 354 4 press press NN cord-258172-p54j4zzo 354 5 Focus Focus NNP cord-258172-p54j4zzo 354 6 on on IN cord-258172-p54j4zzo 354 7 Receptors receptor NNS cord-258172-p54j4zzo 354 8 for for IN cord-258172-p54j4zzo 354 9 Coronaviruses Coronaviruses NNPS cord-258172-p54j4zzo 354 10 with with IN cord-258172-p54j4zzo 354 11 Special Special NNP cord-258172-p54j4zzo 354 12 Reference Reference NNP cord-258172-p54j4zzo 354 13 to to IN cord-258172-p54j4zzo 354 14 Angiotensin angiotensin NN cord-258172-p54j4zzo 354 15 - - HYPH cord-258172-p54j4zzo 354 16 converting convert VBG cord-258172-p54j4zzo 354 17 Enzyme Enzyme NNP cord-258172-p54j4zzo 354 18 2 2 CD cord-258172-p54j4zzo 354 19 as as IN cord-258172-p54j4zzo 354 20 a a DT cord-258172-p54j4zzo 354 21 Potential Potential NNP cord-258172-p54j4zzo 354 22 Drug Drug NNP cord-258172-p54j4zzo 354 23 Target Target NNP cord-258172-p54j4zzo 354 24 - - : cord-258172-p54j4zzo 354 25 A A NNP cord-258172-p54j4zzo 354 26 Perspective Perspective NNP cord-258172-p54j4zzo 354 27 Effect effect NN cord-258172-p54j4zzo 354 28 of of IN cord-258172-p54j4zzo 354 29 angiotensinconverting angiotensinconverte VBG cord-258172-p54j4zzo 354 30 enzyme enzyme NN cord-258172-p54j4zzo 354 31 inhibition inhibition NN cord-258172-p54j4zzo 354 32 and and CC cord-258172-p54j4zzo 354 33 angiotensin angiotensin NN cord-258172-p54j4zzo 354 34 II ii CD cord-258172-p54j4zzo 354 35 receptor receptor NN cord-258172-p54j4zzo 354 36 blockers blocker NNS cord-258172-p54j4zzo 354 37 on on IN cord-258172-p54j4zzo 354 38 cardiac cardiac JJ cord-258172-p54j4zzo 354 39 angiotensin angiotensin NN cord-258172-p54j4zzo 354 40 - - HYPH cord-258172-p54j4zzo 354 41 converting convert VBG cord-258172-p54j4zzo 354 42 enzyme enzyme NN cord-258172-p54j4zzo 354 43 2 2 CD cord-258172-p54j4zzo 354 44 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 354 45 1 1 CD cord-258172-p54j4zzo 354 46 - - SYM cord-258172-p54j4zzo 354 47 7 7 CD cord-258172-p54j4zzo 354 48 promotes promote VBZ cord-258172-p54j4zzo 354 49 cardiac cardiac JJ cord-258172-p54j4zzo 354 50 angiogenesis angiogenesis NN cord-258172-p54j4zzo 354 51 following follow VBG cord-258172-p54j4zzo 354 52 infarction infarction NN cord-258172-p54j4zzo 354 53 Angiotensin angiotensin NN cord-258172-p54j4zzo 354 54 - - HYPH cord-258172-p54j4zzo 354 55 converting convert VBG cord-258172-p54j4zzo 354 56 enzyme enzyme NN cord-258172-p54j4zzo 354 57 2 2 CD cord-258172-p54j4zzo 354 58 priming priming NN cord-258172-p54j4zzo 354 59 enhances enhance VBZ cord-258172-p54j4zzo 354 60 the the DT cord-258172-p54j4zzo 354 61 function function NN cord-258172-p54j4zzo 354 62 of of IN cord-258172-p54j4zzo 354 63 endothelial endothelial JJ cord-258172-p54j4zzo 354 64 progenitor progenitor NN cord-258172-p54j4zzo 354 65 cells cell NNS cord-258172-p54j4zzo 354 66 and and CC cord-258172-p54j4zzo 354 67 their -PRON- PRP$ cord-258172-p54j4zzo 354 68 therapeutic therapeutic JJ cord-258172-p54j4zzo 354 69 efficacy efficacy NN cord-258172-p54j4zzo 354 70 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 354 71 1 1 CD cord-258172-p54j4zzo 354 72 - - SYM cord-258172-p54j4zzo 354 73 7 7 CD cord-258172-p54j4zzo 355 1 inhibits inhibit VBZ cord-258172-p54j4zzo 355 2 angiotensin angiotensin NNP cord-258172-p54j4zzo 356 1 IIstimulated iistimulate VBN cord-258172-p54j4zzo 356 2 head head NN cord-258172-p54j4zzo 356 3 and and CC cord-258172-p54j4zzo 356 4 neck neck NN cord-258172-p54j4zzo 356 5 cancer cancer NN cord-258172-p54j4zzo 356 6 progression progression NN cord-258172-p54j4zzo 356 7 ACE2 ACE2 NNP cord-258172-p54j4zzo 356 8 inhibits inhibit VBZ cord-258172-p54j4zzo 356 9 breast breast NN cord-258172-p54j4zzo 356 10 cancer cancer NN cord-258172-p54j4zzo 356 11 angiogenesis angiogenesis NN cord-258172-p54j4zzo 356 12 via via IN cord-258172-p54j4zzo 356 13 suppressing suppress VBG cord-258172-p54j4zzo 356 14 the the DT cord-258172-p54j4zzo 356 15 VEGFa/ VEGFa/ NNP cord-258172-p54j4zzo 357 1 VEGFR2/ VEGFR2/ NNP cord-258172-p54j4zzo 358 1 ERK ERK NNP cord-258172-p54j4zzo 358 2 pathway pathway NNP cord-258172-p54j4zzo 359 1 The the DT cord-258172-p54j4zzo 359 2 angiotensin angiotensin NN cord-258172-p54j4zzo 359 3 - - HYPH cord-258172-p54j4zzo 359 4 converting convert VBG cord-258172-p54j4zzo 359 5 enzyme enzyme NN cord-258172-p54j4zzo 359 6 2 2 CD cord-258172-p54j4zzo 359 7 in in IN cord-258172-p54j4zzo 359 8 tumor tumor NN cord-258172-p54j4zzo 359 9 growth growth NN cord-258172-p54j4zzo 359 10 and and CC cord-258172-p54j4zzo 359 11 tumor tumor NN cord-258172-p54j4zzo 359 12 - - HYPH cord-258172-p54j4zzo 359 13 associated associate VBN cord-258172-p54j4zzo 359 14 angiogenesis angiogenesis NN cord-258172-p54j4zzo 359 15 in in IN cord-258172-p54j4zzo 359 16 non non JJ cord-258172-p54j4zzo 359 17 - - JJ cord-258172-p54j4zzo 359 18 small small JJ cord-258172-p54j4zzo 359 19 cell cell NN cord-258172-p54j4zzo 359 20 lung lung NN cord-258172-p54j4zzo 359 21 cancer cancer NN cord-258172-p54j4zzo 359 22 ACE2 ACE2 NNP cord-258172-p54j4zzo 359 23 and and CC cord-258172-p54j4zzo 359 24 ANG-(1 ANG-(1 NNP cord-258172-p54j4zzo 359 25 - - SYM cord-258172-p54j4zzo 359 26 7 7 CD cord-258172-p54j4zzo 359 27 ) ) -RRB- cord-258172-p54j4zzo 359 28 in in IN cord-258172-p54j4zzo 359 29 the the DT cord-258172-p54j4zzo 359 30 rat rat NN cord-258172-p54j4zzo 359 31 uterus uterus NN cord-258172-p54j4zzo 359 32 during during IN cord-258172-p54j4zzo 359 33 early early JJ cord-258172-p54j4zzo 359 34 and and CC cord-258172-p54j4zzo 359 35 late late JJ cord-258172-p54j4zzo 359 36 gestation gestation NN cord-258172-p54j4zzo 359 37 Dysfunctional Dysfunctional NNP cord-258172-p54j4zzo 359 38 Coagulation Coagulation NNP cord-258172-p54j4zzo 359 39 in in IN cord-258172-p54j4zzo 359 40 COVID-19 covid-19 NN cord-258172-p54j4zzo 359 41 : : : cord-258172-p54j4zzo 359 42 From from IN cord-258172-p54j4zzo 359 43 Cell cell NN cord-258172-p54j4zzo 359 44 to to IN cord-258172-p54j4zzo 359 45 Bedside Bedside NNP cord-258172-p54j4zzo 359 46 Coagulation Coagulation NNP cord-258172-p54j4zzo 359 47 abnormalities abnormality NNS cord-258172-p54j4zzo 359 48 and and CC cord-258172-p54j4zzo 359 49 thrombosis thrombosis NN cord-258172-p54j4zzo 359 50 in in IN cord-258172-p54j4zzo 359 51 patients patient NNS cord-258172-p54j4zzo 359 52 with with IN cord-258172-p54j4zzo 359 53 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 360 1 The the DT cord-258172-p54j4zzo 360 2 ACE2 ACE2 NNP cord-258172-p54j4zzo 360 3 / / SYM cord-258172-p54j4zzo 360 4 Angiotensin Angiotensin NNP cord-258172-p54j4zzo 360 5 Pulmonary Pulmonary NNP cord-258172-p54j4zzo 360 6 Pathology Pathology NNP cord-258172-p54j4zzo 360 7 of of IN cord-258172-p54j4zzo 360 8 Early Early NNP cord-258172-p54j4zzo 360 9 - - HYPH cord-258172-p54j4zzo 360 10 Phase phase NN cord-258172-p54j4zzo 360 11 2019 2019 CD cord-258172-p54j4zzo 360 12 Novel Novel NNP cord-258172-p54j4zzo 360 13 Coronavirus Coronavirus NNP cord-258172-p54j4zzo 360 14 ( ( -LRB- cord-258172-p54j4zzo 360 15 COVID-19 COVID-19 NNP cord-258172-p54j4zzo 360 16 ) ) -RRB- cord-258172-p54j4zzo 360 17 Pneumonia pneumonia NN cord-258172-p54j4zzo 360 18 in in IN cord-258172-p54j4zzo 360 19 Two two CD cord-258172-p54j4zzo 360 20 Patients patient NNS cord-258172-p54j4zzo 360 21 With with IN cord-258172-p54j4zzo 360 22 Lung lung NN cord-258172-p54j4zzo 360 23 Cancer cancer NN