id	sid	tid	token	lemma	pos
cord-001734-bbeznd3r	1	1	key	key	JJ
cord-001734-bbeznd3r	2	1	:	:	:
cord-001734-bbeznd3r	2	2	cord-001734-bbeznd3r	cord-001734-bbeznd3r	PRP
cord-001734-bbeznd3r	2	3	authors	author	NNS
cord-001734-bbeznd3r	2	4	:	:	:
cord-001734-bbeznd3r	2	5	Gupta	Gupta	NNP
cord-001734-bbeznd3r	2	6	,	,	,
cord-001734-bbeznd3r	2	7	Garvita	Garvita	NNP
cord-001734-bbeznd3r	2	8	;	;	:
cord-001734-bbeznd3r	2	9	Lim	Lim	NNP
cord-001734-bbeznd3r	2	10	,	,	,
cord-001734-bbeznd3r	2	11	Liangzhong	Liangzhong	NNP
cord-001734-bbeznd3r	2	12	;	;	:
cord-001734-bbeznd3r	2	13	Song	Song	NNP
cord-001734-bbeznd3r	2	14	,	,	,
cord-001734-bbeznd3r	2	15	Jianxing	Jianxing	NNP
cord-001734-bbeznd3r	2	16	title	title	NN
cord-001734-bbeznd3r	2	17	:	:	:
cord-001734-bbeznd3r	2	18	NMR	NMR	NNP
cord-001734-bbeznd3r	2	19	and	and	CC
cord-001734-bbeznd3r	2	20	MD	MD	NNP
cord-001734-bbeznd3r	2	21	Studies	Studies	NNPS
cord-001734-bbeznd3r	2	22	Reveal	reveal	VBP
cord-001734-bbeznd3r	2	23	That	that	IN
cord-001734-bbeznd3r	2	24	the	the	DT
cord-001734-bbeznd3r	2	25	Isolated	isolated	JJ
cord-001734-bbeznd3r	2	26	Dengue	Dengue	NNP
cord-001734-bbeznd3r	2	27	NS3	NS3	NNP
cord-001734-bbeznd3r	2	28	Protease	protease	NN
cord-001734-bbeznd3r	2	29	Is	be	VBZ
cord-001734-bbeznd3r	2	30	an	an	DT
cord-001734-bbeznd3r	2	31	Intrinsically	intrinsically	RB
cord-001734-bbeznd3r	2	32	Disordered	disordered	JJ
cord-001734-bbeznd3r	2	33	Chymotrypsin	Chymotrypsin	NNP
cord-001734-bbeznd3r	2	34	Fold	Fold	NNP
cord-001734-bbeznd3r	2	35	Which	which	WDT
cord-001734-bbeznd3r	3	1	Absolutely	absolutely	RB
cord-001734-bbeznd3r	3	2	Requests	request	VBZ
cord-001734-bbeznd3r	3	3	NS2B	NS2B	NNP
cord-001734-bbeznd3r	3	4	for	for	IN
cord-001734-bbeznd3r	3	5	Correct	Correct	NNP
cord-001734-bbeznd3r	3	6	Folding	Folding	NNP
cord-001734-bbeznd3r	3	7	and	and	CC
cord-001734-bbeznd3r	3	8	Functional	Functional	NNP
cord-001734-bbeznd3r	3	9	Dynamics	Dynamics	NNPS
cord-001734-bbeznd3r	3	10	date	date	NN
cord-001734-bbeznd3r	3	11	:	:	:
cord-001734-bbeznd3r	3	12	2015	2015	CD
cord-001734-bbeznd3r	3	13	-	-	HYPH
cord-001734-bbeznd3r	3	14	08	08	CD
cord-001734-bbeznd3r	3	15	-	-	SYM
cord-001734-bbeznd3r	3	16	10	10	CD
cord-001734-bbeznd3r	3	17	journal	journal	NN
cord-001734-bbeznd3r	3	18	:	:	:
cord-001734-bbeznd3r	4	1	PLoS	PLoS	NNP
cord-001734-bbeznd3r	4	2	One	one	CD
cord-001734-bbeznd3r	4	3	DOI	DOI	NNP
cord-001734-bbeznd3r	4	4	:	:	:
cord-001734-bbeznd3r	4	5	10.1371	10.1371	CD
cord-001734-bbeznd3r	4	6	/	/	SYM
cord-001734-bbeznd3r	4	7	journal.pone.0134823	journal.pone.0134823	NNP
cord-001734-bbeznd3r	4	8	sha	sha	NNP
cord-001734-bbeznd3r	4	9	:	:	:
cord-001734-bbeznd3r	4	10	5229d13f7a121dfc9a455d2ec0807e3966da3e19	5229d13f7a121dfc9a455d2ec0807e3966da3e19	CD
cord-001734-bbeznd3r	4	11	doc_id	doc_id	CD
cord-001734-bbeznd3r	4	12	:	:	:
cord-001734-bbeznd3r	4	13	1734	1734	CD
cord-001734-bbeznd3r	4	14	cord_uid	cord_uid	NNS
cord-001734-bbeznd3r	4	15	:	:	:
cord-001734-bbeznd3r	5	1	bbeznd3r	bbeznd3r	NNP
cord-001734-bbeznd3r	6	1	Dengue	dengue	NN
cord-001734-bbeznd3r	6	2	genome	genome	NN
cord-001734-bbeznd3r	6	3	encodes	encode	VBZ
cord-001734-bbeznd3r	6	4	a	a	DT
cord-001734-bbeznd3r	6	5	two	two	CD
cord-001734-bbeznd3r	6	6	component	component	NN
cord-001734-bbeznd3r	6	7	protease	protease	NN
cord-001734-bbeznd3r	6	8	complex	complex	NN
cord-001734-bbeznd3r	6	9	(	(	-LRB-
cord-001734-bbeznd3r	6	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	6	11	-	-	HYPH
cord-001734-bbeznd3r	6	12	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	6	13	)	)	-RRB-
cord-001734-bbeznd3r	6	14	essential	essential	JJ
cord-001734-bbeznd3r	6	15	for	for	IN
cord-001734-bbeznd3r	6	16	the	the	DT
cord-001734-bbeznd3r	6	17	viral	viral	JJ
cord-001734-bbeznd3r	6	18	maturation	maturation	NN
cord-001734-bbeznd3r	6	19	/	/	SYM
cord-001734-bbeznd3r	6	20	infectivity	infectivity	NN
cord-001734-bbeznd3r	6	21	,	,	,
cord-001734-bbeznd3r	6	22	thus	thus	RB
cord-001734-bbeznd3r	6	23	representing	represent	VBG
cord-001734-bbeznd3r	6	24	a	a	DT
cord-001734-bbeznd3r	6	25	key	key	JJ
cord-001734-bbeznd3r	6	26	drug	drug	NN
cord-001734-bbeznd3r	6	27	target	target	NN
cord-001734-bbeznd3r	6	28	.	.	.
cord-001734-bbeznd3r	7	1	Previously	previously	RB
cord-001734-bbeznd3r	7	2	,	,	,
cord-001734-bbeznd3r	7	3	due	due	IN
cord-001734-bbeznd3r	7	4	to	to	IN
cord-001734-bbeznd3r	7	5	its	-PRON-	PRP$
cord-001734-bbeznd3r	7	6	“	"	``
cord-001734-bbeznd3r	7	7	complete	complete	JJ
cord-001734-bbeznd3r	7	8	insolubility	insolubility	NN
cord-001734-bbeznd3r	7	9	”	"	''
cord-001734-bbeznd3r	7	10	,	,	,
cord-001734-bbeznd3r	7	11	the	the	DT
cord-001734-bbeznd3r	7	12	isolated	isolated	JJ
cord-001734-bbeznd3r	7	13	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	7	14	could	could	MD
cord-001734-bbeznd3r	7	15	not	not	RB
cord-001734-bbeznd3r	7	16	be	be	VB
cord-001734-bbeznd3r	7	17	experimentally	experimentally	RB
cord-001734-bbeznd3r	7	18	studied	study	VBN
cord-001734-bbeznd3r	7	19	and	and	CC
cord-001734-bbeznd3r	7	20	it	-PRON-	PRP
cord-001734-bbeznd3r	7	21	remains	remain	VBZ
cord-001734-bbeznd3r	7	22	elusive	elusive	JJ
cord-001734-bbeznd3r	7	23	what	what	WP
cord-001734-bbeznd3r	7	24	structure	structure	NN
cord-001734-bbeznd3r	7	25	it	-PRON-	PRP
cord-001734-bbeznd3r	7	26	adopts	adopt	VBZ
cord-001734-bbeznd3r	7	27	without	without	IN
cord-001734-bbeznd3r	7	28	NS2B	NS2B	NNP
cord-001734-bbeznd3r	7	29	and	and	CC
cord-001734-bbeznd3r	7	30	why	why	WRB
cord-001734-bbeznd3r	7	31	NS2B	NS2B	NNP
cord-001734-bbeznd3r	7	32	is	be	VBZ
cord-001734-bbeznd3r	7	33	indispensable	indispensable	JJ
cord-001734-bbeznd3r	7	34	.	.	.
cord-001734-bbeznd3r	8	1	Here	here	RB
cord-001734-bbeznd3r	8	2	as	as	IN
cord-001734-bbeznd3r	8	3	facilitated	facilitate	VBN
cord-001734-bbeznd3r	8	4	by	by	IN
cord-001734-bbeznd3r	8	5	our	-PRON-	PRP$
cord-001734-bbeznd3r	8	6	previous	previous	JJ
cord-001734-bbeznd3r	8	7	discovery	discovery	NN
cord-001734-bbeznd3r	8	8	,	,	,
cord-001734-bbeznd3r	8	9	the	the	DT
cord-001734-bbeznd3r	8	10	isolated	isolated	JJ
cord-001734-bbeznd3r	8	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	8	12	has	have	VBZ
cord-001734-bbeznd3r	8	13	been	be	VBN
cord-001734-bbeznd3r	8	14	surprisingly	surprisingly	RB
cord-001734-bbeznd3r	8	15	deciphered	decipher	VBN
cord-001734-bbeznd3r	8	16	by	by	IN
cord-001734-bbeznd3r	8	17	NMR	NMR	NNP
cord-001734-bbeznd3r	8	18	to	to	TO
cord-001734-bbeznd3r	8	19	be	be	VB
cord-001734-bbeznd3r	8	20	the	the	DT
cord-001734-bbeznd3r	8	21	first	first	JJ
cord-001734-bbeznd3r	8	22	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	8	23	-	-	HYPH
cord-001734-bbeznd3r	8	24	disordered	disordered	JJ
cord-001734-bbeznd3r	8	25	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	8	26	-	-	HYPH
cord-001734-bbeznd3r	8	27	like	like	JJ
cord-001734-bbeznd3r	8	28	fold	fold	NN
cord-001734-bbeznd3r	8	29	,	,	,
cord-001734-bbeznd3r	8	30	which	which	WDT
cord-001734-bbeznd3r	8	31	exists	exist	VBZ
cord-001734-bbeznd3r	8	32	in	in	IN
cord-001734-bbeznd3r	8	33	a	a	DT
cord-001734-bbeznd3r	8	34	loosely	loosely	RB
cord-001734-bbeznd3r	8	35	-	-	HYPH
cord-001734-bbeznd3r	8	36	packed	pack	VBN
cord-001734-bbeznd3r	8	37	state	state	NN
cord-001734-bbeznd3r	8	38	with	with	IN
cord-001734-bbeznd3r	8	39	non	non	JJ
cord-001734-bbeznd3r	8	40	-	-	JJ
cord-001734-bbeznd3r	8	41	native	native	JJ
cord-001734-bbeznd3r	8	42	long	long	JJ
cord-001734-bbeznd3r	8	43	-	-	HYPH
cord-001734-bbeznd3r	8	44	range	range	NN
cord-001734-bbeznd3r	8	45	interactions	interaction	NNS
cord-001734-bbeznd3r	8	46	as	as	IN
cord-001734-bbeznd3r	8	47	revealed	reveal	VBN
cord-001734-bbeznd3r	8	48	by	by	IN
cord-001734-bbeznd3r	8	49	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	8	50	relaxation	relaxation	NN
cord-001734-bbeznd3r	8	51	enhancement	enhancement	NN
cord-001734-bbeznd3r	8	52	(	(	-LRB-
cord-001734-bbeznd3r	8	53	PRE	PRE	NNP
cord-001734-bbeznd3r	8	54	)	)	-RRB-
cord-001734-bbeznd3r	8	55	.	.	.
cord-001734-bbeznd3r	9	1	The	the	DT
cord-001734-bbeznd3r	9	2	disordered	disordered	JJ
cord-001734-bbeznd3r	9	3	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	9	4	appears	appear	VBZ
cord-001734-bbeznd3r	9	5	to	to	TO
cord-001734-bbeznd3r	9	6	be	be	VB
cord-001734-bbeznd3r	9	7	needed	need	VBN
cord-001734-bbeznd3r	9	8	for	for	IN
cord-001734-bbeznd3r	9	9	binding	bind	VBG
cord-001734-bbeznd3r	9	10	a	a	DT
cord-001734-bbeznd3r	9	11	human	human	JJ
cord-001734-bbeznd3r	9	12	host	host	NN
cord-001734-bbeznd3r	9	13	factor	factor	NN
cord-001734-bbeznd3r	9	14	to	to	TO
cord-001734-bbeznd3r	9	15	trigger	trigger	VB
cord-001734-bbeznd3r	9	16	the	the	DT
cord-001734-bbeznd3r	9	17	membrane	membrane	NN
cord-001734-bbeznd3r	9	18	remodeling	remodeling	NN
cord-001734-bbeznd3r	9	19	.	.	.
cord-001734-bbeznd3r	10	1	Moreover	moreover	RB
cord-001734-bbeznd3r	10	2	,	,	,
cord-001734-bbeznd3r	10	3	we	-PRON-	PRP
cord-001734-bbeznd3r	10	4	have	have	VBP
cord-001734-bbeznd3r	10	5	in	in	IN
cord-001734-bbeznd3r	10	6	vitro	vitro	FW
cord-001734-bbeznd3r	10	7	refolded	refolde	VBD
cord-001734-bbeznd3r	10	8	the	the	DT
cord-001734-bbeznd3r	10	9	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	10	10	in	in	IN
cord-001734-bbeznd3r	10	11	complex	complex	NN
cord-001734-bbeznd3r	10	12	with	with	IN
cord-001734-bbeznd3r	10	13	either	either	DT
cord-001734-bbeznd3r	10	14	NS2B	NS2B	NNP
cord-001734-bbeznd3r	10	15	(	(	-LRB-
cord-001734-bbeznd3r	10	16	48–100	48–100	CD
cord-001734-bbeznd3r	10	17	)	)	-RRB-
cord-001734-bbeznd3r	10	18	or	or	CC
cord-001734-bbeznd3r	10	19	the	the	DT
cord-001734-bbeznd3r	10	20	full	full	JJ
cord-001734-bbeznd3r	10	21	-	-	HYPH
cord-001734-bbeznd3r	10	22	length	length	NN
cord-001734-bbeznd3r	10	23	NS2B	NS2B	NNP
cord-001734-bbeznd3r	10	24	(	(	-LRB-
cord-001734-bbeznd3r	10	25	1–130	1–130	CD
cord-001734-bbeznd3r	10	26	)	)	-RRB-
cord-001734-bbeznd3r	10	27	anchored	anchor	VBN
cord-001734-bbeznd3r	10	28	into	into	IN
cord-001734-bbeznd3r	10	29	the	the	DT
cord-001734-bbeznd3r	10	30	LMPC	LMPC	NNP
cord-001734-bbeznd3r	10	31	micelle	micelle	NN
cord-001734-bbeznd3r	10	32	,	,	,
cord-001734-bbeznd3r	10	33	and	and	CC
cord-001734-bbeznd3r	10	34	the	the	DT
cord-001734-bbeznd3r	10	35	two	two	CD
cord-001734-bbeznd3r	10	36	complexes	complex	NNS
cord-001734-bbeznd3r	10	37	have	have	VBP
cord-001734-bbeznd3r	10	38	similar	similar	JJ
cord-001734-bbeznd3r	10	39	activities	activity	NNS
cord-001734-bbeznd3r	10	40	but	but	CC
cord-001734-bbeznd3r	10	41	different	different	JJ
cord-001734-bbeznd3r	10	42	dynamics	dynamic	NNS
cord-001734-bbeznd3r	10	43	.	.	.
cord-001734-bbeznd3r	11	1	We	-PRON-	PRP
cord-001734-bbeznd3r	11	2	also	also	RB
cord-001734-bbeznd3r	11	3	performed	perform	VBD
cord-001734-bbeznd3r	11	4	molecular	molecular	JJ
cord-001734-bbeznd3r	11	5	dynamics	dynamic	NNS
cord-001734-bbeznd3r	11	6	(	(	-LRB-
cord-001734-bbeznd3r	11	7	MD	MD	NNP
cord-001734-bbeznd3r	11	8	)	)	-RRB-
cord-001734-bbeznd3r	11	9	simulations	simulation	NNS
cord-001734-bbeznd3r	11	10	and	and	CC
cord-001734-bbeznd3r	11	11	the	the	DT
cord-001734-bbeznd3r	11	12	results	result	NNS
cord-001734-bbeznd3r	11	13	revealed	reveal	VBD
cord-001734-bbeznd3r	11	14	that	that	IN
cord-001734-bbeznd3r	11	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	11	16	shows	show	VBZ
cord-001734-bbeznd3r	11	17	the	the	DT
cord-001734-bbeznd3r	11	18	highest	high	JJS
cord-001734-bbeznd3r	11	19	structural	structural	JJ
cord-001734-bbeznd3r	11	20	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	11	21	in	in	IN
cord-001734-bbeznd3r	11	22	the	the	DT
cord-001734-bbeznd3r	11	23	complex	complex	NN
cord-001734-bbeznd3r	11	24	,	,	,
cord-001734-bbeznd3r	11	25	thus	thus	RB
cord-001734-bbeznd3r	11	26	providing	provide	VBG
cord-001734-bbeznd3r	11	27	the	the	DT
cord-001734-bbeznd3r	11	28	dynamic	dynamic	JJ
cord-001734-bbeznd3r	11	29	basis	basis	NN
cord-001734-bbeznd3r	11	30	for	for	IN
cord-001734-bbeznd3r	11	31	the	the	DT
cord-001734-bbeznd3r	11	32	observation	observation	NN
cord-001734-bbeznd3r	11	33	on	on	IN
cord-001734-bbeznd3r	11	34	its	-PRON-	PRP$
cord-001734-bbeznd3r	11	35	conformational	conformational	JJ
cord-001734-bbeznd3r	11	36	exchange	exchange	NN
cord-001734-bbeznd3r	11	37	between	between	IN
cord-001734-bbeznd3r	11	38	open	open	JJ
cord-001734-bbeznd3r	11	39	and	and	CC
cord-001734-bbeznd3r	11	40	closed	closed	JJ
cord-001734-bbeznd3r	11	41	states	state	NNS
cord-001734-bbeznd3r	11	42	.	.	.
cord-001734-bbeznd3r	12	1	Remarkably	remarkably	RB
cord-001734-bbeznd3r	12	2	,	,	,
cord-001734-bbeznd3r	12	3	the	the	DT
cord-001734-bbeznd3r	12	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	12	5	cofactor	cofactor	NN
cord-001734-bbeznd3r	12	6	plays	play	VBZ
cord-001734-bbeznd3r	12	7	a	a	DT
cord-001734-bbeznd3r	12	8	central	central	JJ
cord-001734-bbeznd3r	12	9	role	role	NN
cord-001734-bbeznd3r	12	10	in	in	IN
cord-001734-bbeznd3r	12	11	maintaining	maintain	VBG
cord-001734-bbeznd3r	12	12	the	the	DT
cord-001734-bbeznd3r	12	13	correlated	correlate	VBN
cord-001734-bbeznd3r	12	14	motion	motion	NN
cord-001734-bbeznd3r	12	15	network	network	NN
cord-001734-bbeznd3r	12	16	required	require	VBN
cord-001734-bbeznd3r	12	17	for	for	IN
cord-001734-bbeznd3r	12	18	the	the	DT
cord-001734-bbeznd3r	12	19	catalysis	catalysis	NN
cord-001734-bbeznd3r	12	20	as	as	IN
cord-001734-bbeznd3r	12	21	we	-PRON-	PRP
cord-001734-bbeznd3r	12	22	previously	previously	RB
cord-001734-bbeznd3r	12	23	decoded	decode	VBD
cord-001734-bbeznd3r	12	24	for	for	IN
cord-001734-bbeznd3r	12	25	the	the	DT
cord-001734-bbeznd3r	12	26	SARS	SARS	NNP
cord-001734-bbeznd3r	12	27	3CL	3CL	NNP
cord-001734-bbeznd3r	12	28	protease	protease	NN
cord-001734-bbeznd3r	12	29	.	.	.
cord-001734-bbeznd3r	13	1	Indeed	indeed	RB
cord-001734-bbeznd3r	13	2	,	,	,
cord-001734-bbeznd3r	13	3	a	a	DT
cord-001734-bbeznd3r	13	4	truncated	truncated	JJ
cord-001734-bbeznd3r	13	5	NS2B	NS2B	NNS
cord-001734-bbeznd3r	13	6	(	(	-LRB-
cord-001734-bbeznd3r	13	7	48–100;Δ77–84	48–100;δ77–84	CD
cord-001734-bbeznd3r	13	8	)	)	-RRB-
cord-001734-bbeznd3r	13	9	with	with	IN
cord-001734-bbeznd3r	13	10	the	the	DT
cord-001734-bbeznd3r	13	11	flexible	flexible	JJ
cord-001734-bbeznd3r	13	12	loop	loop	NN
cord-001734-bbeznd3r	13	13	deleted	delete	VBN
cord-001734-bbeznd3r	13	14	is	be	VBZ
cord-001734-bbeznd3r	13	15	able	able	JJ
cord-001734-bbeznd3r	13	16	to	to	TO
cord-001734-bbeznd3r	13	17	trap	trap	VB
cord-001734-bbeznd3r	13	18	the	the	DT
cord-001734-bbeznd3r	13	19	NS2B	NS2B	NNP
cord-001734-bbeznd3r	13	20	-	-	HYPH
cord-001734-bbeznd3r	13	21	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	13	22	complex	complex	NN
cord-001734-bbeznd3r	13	23	in	in	IN
cord-001734-bbeznd3r	13	24	a	a	DT
cord-001734-bbeznd3r	13	25	highly	highly	RB
cord-001734-bbeznd3r	13	26	dynamic	dynamic	JJ
cord-001734-bbeznd3r	13	27	and	and	CC
cord-001734-bbeznd3r	13	28	catalytically	catalytically	RB
cord-001734-bbeznd3r	13	29	-	-	HYPH
cord-001734-bbeznd3r	13	30	impotent	impotent	JJ
cord-001734-bbeznd3r	13	31	state	state	NN
cord-001734-bbeznd3r	13	32	.	.	.
cord-001734-bbeznd3r	14	1	Taken	take	VBN
cord-001734-bbeznd3r	14	2	together	together	RB
cord-001734-bbeznd3r	14	3	,	,	,
cord-001734-bbeznd3r	14	4	our	-PRON-	PRP$
cord-001734-bbeznd3r	14	5	study	study	NN
cord-001734-bbeznd3r	14	6	implies	imply	VBZ
cord-001734-bbeznd3r	14	7	potential	potential	JJ
cord-001734-bbeznd3r	14	8	strategies	strategy	NNS
cord-001734-bbeznd3r	14	9	to	to	TO
cord-001734-bbeznd3r	14	10	perturb	perturb	VB
cord-001734-bbeznd3r	14	11	the	the	DT
cord-001734-bbeznd3r	14	12	NS2B	NS2B	NNP
cord-001734-bbeznd3r	14	13	-	-	HYPH
cord-001734-bbeznd3r	14	14	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	14	15	interface	interface	NN
cord-001734-bbeznd3r	14	16	for	for	IN
cord-001734-bbeznd3r	14	17	design	design	NN
cord-001734-bbeznd3r	14	18	of	of	IN
cord-001734-bbeznd3r	14	19	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	14	20	for	for	IN
cord-001734-bbeznd3r	14	21	treating	treat	VBG
cord-001734-bbeznd3r	14	22	dengue	dengue	NN
cord-001734-bbeznd3r	14	23	infection	infection	NN
cord-001734-bbeznd3r	14	24	.	.	.
cord-001734-bbeznd3r	15	1	Dengue	dengue	NN
cord-001734-bbeznd3r	15	2	is	be	VBZ
cord-001734-bbeznd3r	15	3	the	the	DT
cord-001734-bbeznd3r	15	4	most	most	RBS
cord-001734-bbeznd3r	15	5	prevalent	prevalent	JJ
cord-001734-bbeznd3r	15	6	mosquito	mosquito	NN
cord-001734-bbeznd3r	15	7	-	-	HYPH
cord-001734-bbeznd3r	15	8	borne	bear	VBN
cord-001734-bbeznd3r	15	9	viral	viral	JJ
cord-001734-bbeznd3r	15	10	disease	disease	NN
cord-001734-bbeznd3r	15	11	with	with	IN
cord-001734-bbeznd3r	15	12	over	over	IN
cord-001734-bbeznd3r	15	13	500	500	CD
cord-001734-bbeznd3r	15	14	million	million	CD
cord-001734-bbeznd3r	15	15	human	human	JJ
cord-001734-bbeznd3r	15	16	infections	infection	NNS
cord-001734-bbeznd3r	15	17	annually	annually	RB
cord-001734-bbeznd3r	15	18	and	and	CC
cord-001734-bbeznd3r	15	19	2.5	2.5	CD
cord-001734-bbeznd3r	15	20	billion	billion	CD
cord-001734-bbeznd3r	15	21	people	people	NNS
cord-001734-bbeznd3r	15	22	at	at	IN
cord-001734-bbeznd3r	15	23	risk	risk	NN
cord-001734-bbeznd3r	15	24	,	,	,
cord-001734-bbeznd3r	15	25	particularly	particularly	RB
cord-001734-bbeznd3r	15	26	in	in	IN
cord-001734-bbeznd3r	15	27	tropical	tropical	JJ
cord-001734-bbeznd3r	15	28	and	and	CC
cord-001734-bbeznd3r	15	29	subtropical	subtropical	JJ
cord-001734-bbeznd3r	15	30	regions	region	NNS
cord-001734-bbeznd3r	15	31	[	[	-LRB-
cord-001734-bbeznd3r	15	32	1	1	CD
cord-001734-bbeznd3r	15	33	,	,	,
cord-001734-bbeznd3r	15	34	2	2	CD
cord-001734-bbeznd3r	15	35	]	]	-RRB-
cord-001734-bbeznd3r	15	36	.	.	.
cord-001734-bbeznd3r	16	1	The	the	DT
cord-001734-bbeznd3r	16	2	disease	disease	NN
cord-001734-bbeznd3r	16	3	is	be	VBZ
cord-001734-bbeznd3r	16	4	caused	cause	VBN
cord-001734-bbeznd3r	16	5	by	by	IN
cord-001734-bbeznd3r	16	6	Dengue	Dengue	NNP
cord-001734-bbeznd3r	16	7	virus	virus	NN
cord-001734-bbeznd3r	16	8	(	(	-LRB-
cord-001734-bbeznd3r	16	9	DENV	DENV	NNP
cord-001734-bbeznd3r	16	10	)	)	-RRB-
cord-001734-bbeznd3r	16	11	belonging	belong	VBG
cord-001734-bbeznd3r	16	12	to	to	IN
cord-001734-bbeznd3r	16	13	the	the	DT
cord-001734-bbeznd3r	16	14	Flaviviridae	Flaviviridae	NNP
cord-001734-bbeznd3r	16	15	family	family	NN
cord-001734-bbeznd3r	16	16	,	,	,
cord-001734-bbeznd3r	16	17	which	which	WDT
cord-001734-bbeznd3r	16	18	also	also	RB
cord-001734-bbeznd3r	16	19	includes	include	VBZ
cord-001734-bbeznd3r	16	20	several	several	JJ
cord-001734-bbeznd3r	16	21	other	other	JJ
cord-001734-bbeznd3r	16	22	human	human	JJ
cord-001734-bbeznd3r	16	23	pathogens	pathogen	NNS
cord-001734-bbeznd3r	16	24	such	such	JJ
cord-001734-bbeznd3r	16	25	as	as	IN
cord-001734-bbeznd3r	16	26	the	the	DT
cord-001734-bbeznd3r	16	27	West	West	NNP
cord-001734-bbeznd3r	16	28	Nile	Nile	NNP
cord-001734-bbeznd3r	16	29	virus	virus	NN
cord-001734-bbeznd3r	16	30	,	,	,
cord-001734-bbeznd3r	16	31	Japanese	japanese	JJ
cord-001734-bbeznd3r	16	32	encephalitis	encephalitis	RB
cord-001734-bbeznd3r	16	33	virus	virus	NN
cord-001734-bbeznd3r	16	34	,	,	,
cord-001734-bbeznd3r	16	35	and	and	CC
cord-001734-bbeznd3r	16	36	yellow	yellow	JJ
cord-001734-bbeznd3r	16	37	fever	fever	NN
cord-001734-bbeznd3r	16	38	virus	virus	NN
cord-001734-bbeznd3r	16	39	[	[	-LRB-
cord-001734-bbeznd3r	16	40	1	1	CD
cord-001734-bbeznd3r	16	41	]	]	-RRB-
cord-001734-bbeznd3r	16	42	[	[	-LRB-
cord-001734-bbeznd3r	16	43	2	2	CD
cord-001734-bbeznd3r	16	44	]	]	-RRB-
cord-001734-bbeznd3r	16	45	[	[	-LRB-
cord-001734-bbeznd3r	16	46	3	3	CD
cord-001734-bbeznd3r	16	47	]	]	-RRB-
cord-001734-bbeznd3r	16	48	[	[	-LRB-
cord-001734-bbeznd3r	16	49	4	4	CD
cord-001734-bbeznd3r	16	50	]	]	-RRB-
cord-001734-bbeznd3r	16	51	.	.	.
cord-001734-bbeznd3r	17	1	So	so	RB
cord-001734-bbeznd3r	17	2	far	far	RB
cord-001734-bbeznd3r	17	3	,	,	,
cord-001734-bbeznd3r	17	4	four	four	CD
cord-001734-bbeznd3r	17	5	antigenically	antigenically	RB
cord-001734-bbeznd3r	17	6	distinct	distinct	JJ
cord-001734-bbeznd3r	17	7	DENV	DENV	NNP
cord-001734-bbeznd3r	17	8	serotypes	serotype	NNS
cord-001734-bbeznd3r	17	9	have	have	VBP
cord-001734-bbeznd3r	17	10	been	be	VBN
cord-001734-bbeznd3r	17	11	identified	identify	VBN
cord-001734-bbeznd3r	17	12	:	:	:
cord-001734-bbeznd3r	17	13	DENV-1	DENV-1	NNS
cord-001734-bbeznd3r	17	14	to	to	IN
cord-001734-bbeznd3r	17	15	-4	-4	ADD
cord-001734-bbeznd3r	17	16	,	,	,
cord-001734-bbeznd3r	17	17	all	all	DT
cord-001734-bbeznd3r	17	18	of	of	IN
cord-001734-bbeznd3r	17	19	which	which	WDT
cord-001734-bbeznd3r	17	20	cause	cause	VBP
cord-001734-bbeznd3r	17	21	dengue	dengue	NN
cord-001734-bbeznd3r	17	22	fever	fever	NN
cord-001734-bbeznd3r	17	23	,	,	,
cord-001734-bbeznd3r	17	24	dengue	dengue	NN
cord-001734-bbeznd3r	17	25	haemorrhagic	haemorrhagic	JJ
cord-001734-bbeznd3r	17	26	fever	fever	NN
cord-001734-bbeznd3r	17	27	and	and	CC
cord-001734-bbeznd3r	17	28	dengue	dengue	NN
cord-001734-bbeznd3r	17	29	shock	shock	NN
cord-001734-bbeznd3r	17	30	syndrome	syndrome	NN
cord-001734-bbeznd3r	17	31	.	.	.
cord-001734-bbeznd3r	18	1	Despite	despite	IN
cord-001734-bbeznd3r	18	2	intense	intense	JJ
cord-001734-bbeznd3r	18	3	studies	study	NNS
cord-001734-bbeznd3r	18	4	,	,	,
cord-001734-bbeznd3r	18	5	currently	currently	RB
cord-001734-bbeznd3r	18	6	there	there	EX
cord-001734-bbeznd3r	18	7	are	be	VBP
cord-001734-bbeznd3r	18	8	neither	neither	DT
cord-001734-bbeznd3r	18	9	vaccines	vaccine	NNS
cord-001734-bbeznd3r	18	10	nor	nor	CC
cord-001734-bbeznd3r	18	11	other	other	JJ
cord-001734-bbeznd3r	18	12	treatments	treatment	NNS
cord-001734-bbeznd3r	18	13	available	available	JJ
cord-001734-bbeznd3r	18	14	to	to	TO
cord-001734-bbeznd3r	18	15	treat	treat	VB
cord-001734-bbeznd3r	18	16	this	this	DT
cord-001734-bbeznd3r	18	17	disease	disease	NN
cord-001734-bbeznd3r	18	18	[	[	-LRB-
cord-001734-bbeznd3r	18	19	5	5	CD
cord-001734-bbeznd3r	18	20	,	,	,
cord-001734-bbeznd3r	18	21	6	6	CD
cord-001734-bbeznd3r	18	22	]	]	-RRB-
cord-001734-bbeznd3r	18	23	.	.	.
cord-001734-bbeznd3r	19	1	The	the	DT
cord-001734-bbeznd3r	19	2	DENV	DENV	NNP
cord-001734-bbeznd3r	19	3	genome	genome	NN
cord-001734-bbeznd3r	19	4	is	be	VBZ
cord-001734-bbeznd3r	19	5	composed	compose	VBN
cord-001734-bbeznd3r	19	6	of	of	IN
cord-001734-bbeznd3r	19	7	an	an	DT
cord-001734-bbeznd3r	19	8	11-kb	11-kb	CD
cord-001734-bbeznd3r	19	9	single	single	RB
cord-001734-bbeznd3r	19	10	-	-	HYPH
cord-001734-bbeznd3r	19	11	stranded	strand	VBN
cord-001734-bbeznd3r	19	12	positive	positive	JJ
cord-001734-bbeznd3r	19	13	sense	sense	NN
cord-001734-bbeznd3r	19	14	RNA	RNA	NNP
cord-001734-bbeznd3r	19	15	.	.	.
cord-001734-bbeznd3r	20	1	Upon	upon	IN
cord-001734-bbeznd3r	20	2	infection	infection	NN
cord-001734-bbeznd3r	20	3	,	,	,
cord-001734-bbeznd3r	20	4	the	the	DT
cord-001734-bbeznd3r	20	5	RNA	RNA	NNP
cord-001734-bbeznd3r	20	6	genome	genome	NN
cord-001734-bbeznd3r	20	7	is	be	VBZ
cord-001734-bbeznd3r	20	8	translated	translate	VBN
cord-001734-bbeznd3r	20	9	into	into	IN
cord-001734-bbeznd3r	20	10	a	a	DT
cord-001734-bbeznd3r	20	11	large	large	JJ
cord-001734-bbeznd3r	20	12	polyprotein	polyprotein	NN
cord-001734-bbeznd3r	20	13	by	by	IN
cord-001734-bbeznd3r	20	14	the	the	DT
cord-001734-bbeznd3r	20	15	host	host	NN
cord-001734-bbeznd3r	20	16	-	-	HYPH
cord-001734-bbeznd3r	20	17	cell	cell	NN
cord-001734-bbeznd3r	20	18	translation	translation	NN
cord-001734-bbeznd3r	20	19	machinery	machinery	NN
cord-001734-bbeznd3r	20	20	,	,	,
cord-001734-bbeznd3r	20	21	that	that	WDT
cord-001734-bbeznd3r	20	22	is	be	VBZ
cord-001734-bbeznd3r	20	23	subsequently	subsequently	RB
cord-001734-bbeznd3r	20	24	processed	process	VBN
cord-001734-bbeznd3r	20	25	into	into	IN
cord-001734-bbeznd3r	20	26	10	10	CD
cord-001734-bbeznd3r	20	27	proteins	protein	NNS
cord-001734-bbeznd3r	20	28	,	,	,
cord-001734-bbeznd3r	20	29	including	include	VBG
cord-001734-bbeznd3r	20	30	three	three	CD
cord-001734-bbeznd3r	20	31	structural	structural	JJ
cord-001734-bbeznd3r	20	32	proteins	protein	NNS
cord-001734-bbeznd3r	20	33	(	(	-LRB-
cord-001734-bbeznd3r	20	34	capsid	capsid	NN
cord-001734-bbeznd3r	20	35	,	,	,
cord-001734-bbeznd3r	20	36	membrane	membrane	NN
cord-001734-bbeznd3r	20	37	,	,	,
cord-001734-bbeznd3r	20	38	and	and	CC
cord-001734-bbeznd3r	20	39	envelope	envelope	NN
cord-001734-bbeznd3r	20	40	)	)	-RRB-
cord-001734-bbeznd3r	20	41	and	and	CC
cord-001734-bbeznd3r	20	42	seven	seven	CD
cord-001734-bbeznd3r	20	43	nonstructural	nonstructural	JJ
cord-001734-bbeznd3r	20	44	proteins	protein	NNS
cord-001734-bbeznd3r	20	45	(	(	-LRB-
cord-001734-bbeznd3r	20	46	NS1	ns1	UH
cord-001734-bbeznd3r	20	47	,	,	,
cord-001734-bbeznd3r	20	48	NS2A	NS2A	NNP
cord-001734-bbeznd3r	20	49	/	/	SYM
cord-001734-bbeznd3r	20	50	B	B	NNP
cord-001734-bbeznd3r	20	51	,	,	,
cord-001734-bbeznd3r	20	52	NS3	ns3	RB
cord-001734-bbeznd3r	20	53	,	,	,
cord-001734-bbeznd3r	20	54	NS4A	NS4A	NNP
cord-001734-bbeznd3r	20	55	/	/	SYM
cord-001734-bbeznd3r	20	56	B	B	NNP
cord-001734-bbeznd3r	20	57	,	,	,
cord-001734-bbeznd3r	20	58	and	and	CC
cord-001734-bbeznd3r	20	59	NS5	NS5	NNP
cord-001734-bbeznd3r	20	60	)	)	-RRB-
cord-001734-bbeznd3r	20	61	.	.	.
cord-001734-bbeznd3r	21	1	The	the	DT
cord-001734-bbeznd3r	21	2	structural	structural	JJ
cord-001734-bbeznd3r	21	3	proteins	protein	NNS
cord-001734-bbeznd3r	21	4	form	form	VBP
cord-001734-bbeznd3r	21	5	the	the	DT
cord-001734-bbeznd3r	21	6	viral	viral	JJ
cord-001734-bbeznd3r	21	7	particle	particle	NN
cord-001734-bbeznd3r	21	8	while	while	IN
cord-001734-bbeznd3r	21	9	the	the	DT
cord-001734-bbeznd3r	21	10	nonstructural	nonstructural	JJ
cord-001734-bbeznd3r	21	11	proteins	protein	NNS
cord-001734-bbeznd3r	21	12	participate	participate	VBP
cord-001734-bbeznd3r	21	13	in	in	IN
cord-001734-bbeznd3r	21	14	the	the	DT
cord-001734-bbeznd3r	21	15	replication	replication	NN
cord-001734-bbeznd3r	21	16	of	of	IN
cord-001734-bbeznd3r	21	17	the	the	DT
cord-001734-bbeznd3r	21	18	RNA	RNA	NNP
cord-001734-bbeznd3r	21	19	genome	genome	NN
cord-001734-bbeznd3r	21	20	,	,	,
cord-001734-bbeznd3r	21	21	virion	virion	NN
cord-001734-bbeznd3r	21	22	assembly	assembly	NN
cord-001734-bbeznd3r	21	23	,	,	,
cord-001734-bbeznd3r	21	24	and	and	CC
cord-001734-bbeznd3r	21	25	attenuation	attenuation	NN
cord-001734-bbeznd3r	21	26	of	of	IN
cord-001734-bbeznd3r	21	27	the	the	DT
cord-001734-bbeznd3r	21	28	host	host	NN
cord-001734-bbeznd3r	21	29	antiviral	antiviral	JJ
cord-001734-bbeznd3r	21	30	response	response	NN
cord-001734-bbeznd3r	21	31	.	.	.
cord-001734-bbeznd3r	22	1	The	the	DT
cord-001734-bbeznd3r	22	2	cleavage	cleavage	NN
cord-001734-bbeznd3r	22	3	of	of	IN
cord-001734-bbeznd3r	22	4	the	the	DT
cord-001734-bbeznd3r	22	5	polyprotein	polyprotein	NN
cord-001734-bbeznd3r	22	6	is	be	VBZ
cord-001734-bbeznd3r	22	7	carried	carry	VBN
cord-001734-bbeznd3r	22	8	out	out	RP
cord-001734-bbeznd3r	22	9	by	by	IN
cord-001734-bbeznd3r	22	10	host	host	NN
cord-001734-bbeznd3r	22	11	cell	cell	NN
cord-001734-bbeznd3r	22	12	proteases	protease	NNS
cord-001734-bbeznd3r	22	13	including	include	VBG
cord-001734-bbeznd3r	22	14	furin	furin	NN
cord-001734-bbeznd3r	22	15	and	and	CC
cord-001734-bbeznd3r	22	16	signalaseas	signalaseas	NNP
cord-001734-bbeznd3r	22	17	,	,	,
cord-001734-bbeznd3r	22	18	as	as	RB
cord-001734-bbeznd3r	22	19	well	well	RB
cord-001734-bbeznd3r	22	20	as	as	IN
cord-001734-bbeznd3r	22	21	a	a	DT
cord-001734-bbeznd3r	22	22	virus	virus	NN
cord-001734-bbeznd3r	22	23	-	-	HYPH
cord-001734-bbeznd3r	22	24	encoded	encode	VBN
cord-001734-bbeznd3r	22	25	serine	serine	NN
cord-001734-bbeznd3r	22	26	protease	protease	NN
cord-001734-bbeznd3r	22	27	NS2B	NS2B	NNP
cord-001734-bbeznd3r	22	28	-	-	HYPH
cord-001734-bbeznd3r	22	29	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	22	30	,	,	,
cord-001734-bbeznd3r	22	31	which	which	WDT
cord-001734-bbeznd3r	22	32	has	have	VBZ
cord-001734-bbeznd3r	22	33	been	be	VBN
cord-001734-bbeznd3r	22	34	established	establish	VBN
cord-001734-bbeznd3r	22	35	as	as	IN
cord-001734-bbeznd3r	22	36	a	a	DT
cord-001734-bbeznd3r	22	37	valuable	valuable	JJ
cord-001734-bbeznd3r	22	38	target	target	NN
cord-001734-bbeznd3r	22	39	of	of	IN
cord-001734-bbeznd3r	22	40	therapeutic	therapeutic	JJ
cord-001734-bbeznd3r	22	41	interest	interest	NN
cord-001734-bbeznd3r	22	42	[	[	-LRB-
cord-001734-bbeznd3r	22	43	5	5	CD
cord-001734-bbeznd3r	22	44	,	,	,
cord-001734-bbeznd3r	22	45	6	6	CD
cord-001734-bbeznd3r	22	46	]	]	-RRB-
cord-001734-bbeznd3r	22	47	.	.	.
cord-001734-bbeznd3r	23	1	The	the	DT
cord-001734-bbeznd3r	23	2	protease	protease	NN
cord-001734-bbeznd3r	23	3	domain	domain	NN
cord-001734-bbeznd3r	24	1	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	24	2	consisting	consist	VBG
cord-001734-bbeznd3r	24	3	of	of	IN
cord-001734-bbeznd3r	24	4	the	the	DT
cord-001734-bbeznd3r	24	5	N	n	CD
cord-001734-bbeznd3r	24	6	-	-	HYPH
cord-001734-bbeznd3r	24	7	terminal	terminal	JJ
cord-001734-bbeznd3r	24	8	part	part	NN
cord-001734-bbeznd3r	24	9	of	of	IN
cord-001734-bbeznd3r	24	10	NS3	ns3	RB
cord-001734-bbeznd3r	24	11	adopts	adopt	VBZ
cord-001734-bbeznd3r	24	12	a	a	DT
cord-001734-bbeznd3r	24	13	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	24	14	-	-	HYPH
cord-001734-bbeznd3r	24	15	like	like	JJ
cord-001734-bbeznd3r	24	16	fold	fold	VB
cord-001734-bbeznd3r	24	17	with	with	IN
cord-001734-bbeznd3r	24	18	two	two	CD
cord-001734-bbeznd3r	24	19	β	β	NN
cord-001734-bbeznd3r	24	20	-	-	HYPH
cord-001734-bbeznd3r	24	21	barrels	barrel	NNS
cord-001734-bbeznd3r	24	22	,	,	,
cord-001734-bbeznd3r	24	23	each	each	DT
cord-001734-bbeznd3r	24	24	composed	compose	VBN
cord-001734-bbeznd3r	24	25	of	of	IN
cord-001734-bbeznd3r	24	26	six	six	CD
cord-001734-bbeznd3r	24	27	β	β	NN
cord-001734-bbeznd3r	24	28	-	-	HYPH
cord-001734-bbeznd3r	24	29	strands	strand	NNS
cord-001734-bbeznd3r	24	30	,	,	,
cord-001734-bbeznd3r	24	31	with	with	IN
cord-001734-bbeznd3r	24	32	the	the	DT
cord-001734-bbeznd3r	24	33	catalytic	catalytic	JJ
cord-001734-bbeznd3r	24	34	triad	triad	NN
cord-001734-bbeznd3r	24	35	(	(	-LRB-
cord-001734-bbeznd3r	24	36	His51-Asp75-Ser135	His51-Asp75-Ser135	NNP
cord-001734-bbeznd3r	24	37	)	)	-RRB-
cord-001734-bbeznd3r	24	38	located	locate	VBN
cord-001734-bbeznd3r	24	39	at	at	IN
cord-001734-bbeznd3r	24	40	the	the	DT
cord-001734-bbeznd3r	24	41	cleft	cleft	NN
cord-001734-bbeznd3r	24	42	between	between	IN
cord-001734-bbeznd3r	24	43	the	the	DT
cord-001734-bbeznd3r	24	44	two	two	CD
cord-001734-bbeznd3r	24	45	β	β	NN
cord-001734-bbeznd3r	24	46	-	-	HYPH
cord-001734-bbeznd3r	24	47	barrels	barrel	NNS
cord-001734-bbeznd3r	24	48	[	[	-LRB-
cord-001734-bbeznd3r	24	49	7	7	CD
cord-001734-bbeznd3r	24	50	,	,	,
cord-001734-bbeznd3r	24	51	8	8	CD
cord-001734-bbeznd3r	24	52	]	]	-RRB-
cord-001734-bbeznd3r	24	53	.	.	.
cord-001734-bbeznd3r	25	1	Amazingly	amazingly	RB
cord-001734-bbeznd3r	25	2	,	,	,
cord-001734-bbeznd3r	25	3	unlike	unlike	IN
cord-001734-bbeznd3r	25	4	other	other	JJ
cord-001734-bbeznd3r	25	5	proteases	protease	NNS
cord-001734-bbeznd3r	25	6	with	with	IN
cord-001734-bbeznd3r	25	7	a	a	DT
cord-001734-bbeznd3r	25	8	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	25	9	-	-	HYPH
cord-001734-bbeznd3r	25	10	like	like	JJ
cord-001734-bbeznd3r	25	11	fold	fold	NN
cord-001734-bbeznd3r	25	12	,	,	,
cord-001734-bbeznd3r	25	13	the	the	DT
cord-001734-bbeznd3r	25	14	flavivirus	flavivirus	JJ
cord-001734-bbeznd3r	25	15	proteases	protease	NNS
cord-001734-bbeznd3r	25	16	including	include	VBG
cord-001734-bbeznd3r	25	17	dengue	dengue	NN
cord-001734-bbeznd3r	25	18	protease	protease	NN
cord-001734-bbeznd3r	25	19	,	,	,
cord-001734-bbeznd3r	25	20	requires	require	VBZ
cord-001734-bbeznd3r	25	21	a	a	DT
cord-001734-bbeznd3r	25	22	stretch	stretch	NN
cord-001734-bbeznd3r	25	23	of	of	IN
cord-001734-bbeznd3r	25	24	approximately	approximately	RB
cord-001734-bbeznd3r	25	25	40	40	CD
cord-001734-bbeznd3r	25	26	amino	amino	NN
cord-001734-bbeznd3r	25	27	acids	acid	NNS
cord-001734-bbeznd3r	25	28	from	from	IN
cord-001734-bbeznd3r	25	29	the	the	DT
cord-001734-bbeznd3r	25	30	cytosolic	cytosolic	JJ
cord-001734-bbeznd3r	25	31	domain	domain	NN
cord-001734-bbeznd3r	25	32	of	of	IN
cord-001734-bbeznd3r	25	33	NS2B	NS2B	NNP
cord-001734-bbeznd3r	25	34	for	for	IN
cord-001734-bbeznd3r	25	35	catalytic	catalytic	JJ
cord-001734-bbeznd3r	25	36	activity	activity	NN
cord-001734-bbeznd3r	25	37	,	,	,
cord-001734-bbeznd3r	25	38	thus	thus	RB
cord-001734-bbeznd3r	25	39	called	call	VBN
cord-001734-bbeznd3r	25	40	two	two	CD
cord-001734-bbeznd3r	25	41	-	-	HYPH
cord-001734-bbeznd3r	25	42	component	component	NN
cord-001734-bbeznd3r	25	43	protease	protease	NN
cord-001734-bbeznd3r	25	44	[	[	-LRB-
cord-001734-bbeznd3r	25	45	6	6	CD
cord-001734-bbeznd3r	25	46	]	]	-RRB-
cord-001734-bbeznd3r	25	47	[	[	-LRB-
cord-001734-bbeznd3r	25	48	7	7	CD
cord-001734-bbeznd3r	25	49	]	]	-RRB-
cord-001734-bbeznd3r	25	50	[	[	-LRB-
cord-001734-bbeznd3r	25	51	8	8	CD
cord-001734-bbeznd3r	25	52	]	]	-RRB-
cord-001734-bbeznd3r	25	53	.	.	.
cord-001734-bbeznd3r	26	1	Intriguingly	intriguingly	RB
cord-001734-bbeznd3r	26	2	,	,	,
cord-001734-bbeznd3r	26	3	while	while	IN
cord-001734-bbeznd3r	26	4	the	the	DT
cord-001734-bbeznd3r	26	5	protease	protease	NN
cord-001734-bbeznd3r	26	6	domains	domain	NNS
cord-001734-bbeznd3r	26	7	adopt	adopt	VBP
cord-001734-bbeznd3r	26	8	highly	highly	RB
cord-001734-bbeznd3r	26	9	similar	similar	JJ
cord-001734-bbeznd3r	26	10	structures	structure	NNS
cord-001734-bbeznd3r	26	11	in	in	IN
cord-001734-bbeznd3r	26	12	all	all	DT
cord-001734-bbeznd3r	26	13	crystal	crystal	NN
cord-001734-bbeznd3r	26	14	structures	structure	NNS
cord-001734-bbeznd3r	26	15	determined	determine	VBN
cord-001734-bbeznd3r	26	16	to	to	IN
cord-001734-bbeznd3r	26	17	date	date	NN
cord-001734-bbeznd3r	26	18	,	,	,
cord-001734-bbeznd3r	26	19	the	the	DT
cord-001734-bbeznd3r	26	20	NS2B	NS2B	NNP
cord-001734-bbeznd3r	26	21	cofactors	cofactor	NNS
cord-001734-bbeznd3r	26	22	have	have	VBP
cord-001734-bbeznd3r	26	23	been	be	VBN
cord-001734-bbeznd3r	26	24	found	find	VBN
cord-001734-bbeznd3r	26	25	to	to	TO
cord-001734-bbeznd3r	26	26	assume	assume	VB
cord-001734-bbeznd3r	26	27	two	two	CD
cord-001734-bbeznd3r	26	28	distinctive	distinctive	JJ
cord-001734-bbeznd3r	26	29	structures	structure	NNS
cord-001734-bbeznd3r	26	30	,	,	,
cord-001734-bbeznd3r	26	31	namely	namely	RB
cord-001734-bbeznd3r	26	32	open	open	JJ
cord-001734-bbeznd3r	26	33	(	(	-LRB-
cord-001734-bbeznd3r	26	34	inactive	inactive	JJ
cord-001734-bbeznd3r	26	35	)	)	-RRB-
cord-001734-bbeznd3r	26	36	and	and	CC
cord-001734-bbeznd3r	26	37	closed	close	VBN
cord-001734-bbeznd3r	26	38	(	(	-LRB-
cord-001734-bbeznd3r	26	39	active	active	JJ
cord-001734-bbeznd3r	26	40	)	)	-RRB-
cord-001734-bbeznd3r	26	41	conformations	conformation	NNS
cord-001734-bbeznd3r	26	42	by	by	IN
cord-001734-bbeznd3r	26	43	X	x	NN
cord-001734-bbeznd3r	26	44	-	-	NN
cord-001734-bbeznd3r	26	45	ray	ray	JJ
cord-001734-bbeznd3r	26	46	crystallography	crystallography	NN
cord-001734-bbeznd3r	26	47	and	and	CC
cord-001734-bbeznd3r	26	48	NMR	NMR	NNP
cord-001734-bbeznd3r	26	49	spectroscopy	spectroscopy	NN
cord-001734-bbeznd3r	26	50	[	[	-LRB-
cord-001734-bbeznd3r	26	51	7	7	CD
cord-001734-bbeznd3r	26	52	]	]	-RRB-
cord-001734-bbeznd3r	26	53	[	[	-LRB-
cord-001734-bbeznd3r	26	54	8	8	CD
cord-001734-bbeznd3r	26	55	]	]	-RRB-
cord-001734-bbeznd3r	26	56	[	[	-LRB-
cord-001734-bbeznd3r	26	57	9	9	CD
cord-001734-bbeznd3r	26	58	]	]	-RRB-
cord-001734-bbeznd3r	26	59	[	[	-LRB-
cord-001734-bbeznd3r	26	60	10	10	CD
cord-001734-bbeznd3r	26	61	]	]	-RRB-
cord-001734-bbeznd3r	26	62	[	[	-LRB-
cord-001734-bbeznd3r	26	63	11	11	CD
cord-001734-bbeznd3r	26	64	]	]	-RRB-
cord-001734-bbeznd3r	26	65	[	[	-LRB-
cord-001734-bbeznd3r	26	66	12	12	CD
cord-001734-bbeznd3r	26	67	]	]	-RRB-
cord-001734-bbeznd3r	26	68	.	.	.
cord-001734-bbeznd3r	27	1	To	to	TO
cord-001734-bbeznd3r	27	2	understand	understand	VB
cord-001734-bbeznd3r	27	3	why	why	WRB
cord-001734-bbeznd3r	27	4	the	the	DT
cord-001734-bbeznd3r	27	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	27	6	cofactor	cofactor	NN
cord-001734-bbeznd3r	27	7	is	be	VBZ
cord-001734-bbeznd3r	27	8	indispensable	indispensable	JJ
cord-001734-bbeznd3r	27	9	for	for	IN
cord-001734-bbeznd3r	27	10	activating	activate	VBG
cord-001734-bbeznd3r	27	11	the	the	DT
cord-001734-bbeznd3r	27	12	dengue	dengue	NN
cord-001734-bbeznd3r	27	13	NS3	ns3	RB
cord-001734-bbeznd3r	27	14	protease	protease	NN
cord-001734-bbeznd3r	28	1	is	be	VBZ
cord-001734-bbeznd3r	28	2	not	not	RB
cord-001734-bbeznd3r	28	3	only	only	RB
cord-001734-bbeznd3r	28	4	of	of	IN
cord-001734-bbeznd3r	28	5	fundamental	fundamental	JJ
cord-001734-bbeznd3r	28	6	interest	interest	NN
cord-001734-bbeznd3r	28	7	for	for	IN
cord-001734-bbeznd3r	28	8	enzymology	enzymology	NN
cord-001734-bbeznd3r	28	9	,	,	,
cord-001734-bbeznd3r	28	10	but	but	CC
cord-001734-bbeznd3r	28	11	also	also	RB
cord-001734-bbeznd3r	28	12	bears	bear	VBZ
cord-001734-bbeznd3r	28	13	considerable	considerable	JJ
cord-001734-bbeznd3r	28	14	implications	implication	NNS
cord-001734-bbeznd3r	28	15	for	for	IN
cord-001734-bbeznd3r	28	16	design	design	NN
cord-001734-bbeznd3r	28	17	of	of	IN
cord-001734-bbeznd3r	28	18	molecules	molecule	NNS
cord-001734-bbeznd3r	28	19	with	with	IN
cord-001734-bbeznd3r	28	20	high	high	JJ
cord-001734-bbeznd3r	28	21	affinity	affinity	NN
cord-001734-bbeznd3r	28	22	and	and	CC
cord-001734-bbeznd3r	28	23	specificity	specificity	NN
cord-001734-bbeznd3r	28	24	to	to	TO
cord-001734-bbeznd3r	28	25	inhibit	inhibit	VB
cord-001734-bbeznd3r	28	26	the	the	DT
cord-001734-bbeznd3r	28	27	protease	protease	NN
cord-001734-bbeznd3r	28	28	[	[	-LRB-
cord-001734-bbeznd3r	28	29	13	13	CD
cord-001734-bbeznd3r	28	30	,	,	,
cord-001734-bbeznd3r	28	31	14	14	CD
cord-001734-bbeznd3r	28	32	]	]	-RRB-
cord-001734-bbeznd3r	28	33	.	.	.
cord-001734-bbeznd3r	29	1	However	however	RB
cord-001734-bbeznd3r	29	2	,	,	,
cord-001734-bbeznd3r	29	3	due	due	IN
cord-001734-bbeznd3r	29	4	to	to	IN
cord-001734-bbeznd3r	29	5	its	-PRON-	PRP$
cord-001734-bbeznd3r	29	6	"	"	``
cord-001734-bbeznd3r	29	7	complete	complete	JJ
cord-001734-bbeznd3r	29	8	insolubility	insolubility	NN
cord-001734-bbeznd3r	29	9	"	"	''
cord-001734-bbeznd3r	29	10	,	,	,
cord-001734-bbeznd3r	29	11	it	-PRON-	PRP
cord-001734-bbeznd3r	29	12	has	have	VBZ
cord-001734-bbeznd3r	29	13	been	be	VBN
cord-001734-bbeznd3r	29	14	previously	previously	RB
cord-001734-bbeznd3r	29	15	impossible	impossible	JJ
cord-001734-bbeznd3r	29	16	to	to	TO
cord-001734-bbeznd3r	29	17	carry	carry	VB
cord-001734-bbeznd3r	29	18	out	out	RP
cord-001734-bbeznd3r	29	19	any	any	DT
cord-001734-bbeznd3r	29	20	experimental	experimental	JJ
cord-001734-bbeznd3r	29	21	studies	study	NNS
cord-001734-bbeznd3r	29	22	on	on	IN
cord-001734-bbeznd3r	29	23	the	the	DT
cord-001734-bbeznd3r	29	24	isolated	isolated	JJ
cord-001734-bbeznd3r	29	25	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	29	26	domain	domain	NN
cord-001734-bbeznd3r	29	27	.	.	.
cord-001734-bbeznd3r	30	1	In	in	IN
cord-001734-bbeznd3r	30	2	2005	2005	CD
cord-001734-bbeznd3r	30	3	,	,	,
cord-001734-bbeznd3r	30	4	we	-PRON-	PRP
cord-001734-bbeznd3r	30	5	discovered	discover	VBD
cord-001734-bbeznd3r	30	6	that	that	IN
cord-001734-bbeznd3r	30	7	previously	previously	RB
cord-001734-bbeznd3r	30	8	-	-	HYPH
cord-001734-bbeznd3r	30	9	thought	think	VBN
cord-001734-bbeznd3r	30	10	"	"	``
cord-001734-bbeznd3r	30	11	insoluble	insoluble	JJ
cord-001734-bbeznd3r	30	12	proteins	protein	NNS
cord-001734-bbeznd3r	30	13	"	"	''
cord-001734-bbeznd3r	30	14	in	in	IN
cord-001734-bbeznd3r	30	15	fact	fact	NN
cord-001734-bbeznd3r	30	16	could	could	MD
cord-001734-bbeznd3r	30	17	be	be	VB
cord-001734-bbeznd3r	30	18	solubilized	solubilize	VBN
cord-001734-bbeznd3r	30	19	in	in	IN
cord-001734-bbeznd3r	30	20	water	water	NN
cord-001734-bbeznd3r	30	21	with	with	IN
cord-001734-bbeznd3r	30	22	minimized	minimize	VBN
cord-001734-bbeznd3r	30	23	salt	salt	NN
cord-001734-bbeznd3r	30	24	ions	ion	NNS
cord-001734-bbeznd3r	30	25	[	[	-LRB-
cord-001734-bbeznd3r	30	26	15	15	CD
cord-001734-bbeznd3r	30	27	]	]	-RRB-
cord-001734-bbeznd3r	30	28	[	[	-LRB-
cord-001734-bbeznd3r	30	29	16	16	CD
cord-001734-bbeznd3r	30	30	]	]	-RRB-
cord-001734-bbeznd3r	30	31	[	[	-LRB-
cord-001734-bbeznd3r	30	32	17	17	CD
cord-001734-bbeznd3r	30	33	]	]	-RRB-
cord-001734-bbeznd3r	30	34	[	[	-LRB-
cord-001734-bbeznd3r	30	35	18	18	CD
cord-001734-bbeznd3r	30	36	]	]	-RRB-
cord-001734-bbeznd3r	30	37	,	,	,
cord-001734-bbeznd3r	30	38	and	and	CC
cord-001734-bbeznd3r	30	39	therefore	therefore	RB
cord-001734-bbeznd3r	30	40	we	-PRON-	PRP
cord-001734-bbeznd3r	30	41	have	have	VBP
cord-001734-bbeznd3r	30	42	used	use	VBN
cord-001734-bbeznd3r	30	43	this	this	DT
cord-001734-bbeznd3r	30	44	to	to	TO
cord-001734-bbeznd3r	30	45	study	study	VB
cord-001734-bbeznd3r	30	46	various	various	JJ
cord-001734-bbeznd3r	30	47	previously	previously	RB
cord-001734-bbeznd3r	30	48	-	-	HYPH
cord-001734-bbeznd3r	30	49	thought	think	VBN
cord-001734-bbeznd3r	30	50	insoluble	insoluble	JJ
cord-001734-bbeznd3r	30	51	proteins	protein	NNS
cord-001734-bbeznd3r	30	52	including	include	VBG
cord-001734-bbeznd3r	30	53	TDP-43	TDP-43	NNP
cord-001734-bbeznd3r	30	54	N	N	NNP
cord-001734-bbeznd3r	30	55	-	-	HYPH
cord-001734-bbeznd3r	30	56	terminus	terminus	NN
cord-001734-bbeznd3r	30	57	[	[	-LRB-
cord-001734-bbeznd3r	30	58	19	19	CD
cord-001734-bbeznd3r	30	59	]	]	-RRB-
cord-001734-bbeznd3r	30	60	.	.	.
cord-001734-bbeznd3r	31	1	Here	here	RB
cord-001734-bbeznd3r	31	2	with	with	IN
cord-001734-bbeznd3r	31	3	this	this	DT
cord-001734-bbeznd3r	31	4	approach	approach	NN
cord-001734-bbeznd3r	31	5	,	,	,
cord-001734-bbeznd3r	31	6	we	-PRON-	PRP
cord-001734-bbeznd3r	31	7	have	have	VBP
cord-001734-bbeznd3r	31	8	successfully	successfully	RB
cord-001734-bbeznd3r	31	9	characterized	characterize	VBN
cord-001734-bbeznd3r	31	10	the	the	DT
cord-001734-bbeznd3r	31	11	solution	solution	NN
cord-001734-bbeznd3r	31	12	conformations	conformation	NNS
cord-001734-bbeznd3r	31	13	and	and	CC
cord-001734-bbeznd3r	31	14	dynamics	dynamic	NNS
cord-001734-bbeznd3r	31	15	of	of	IN
cord-001734-bbeznd3r	31	16	the	the	DT
cord-001734-bbeznd3r	31	17	isolated	isolate	VBN
cord-001734-bbeznd3r	31	18	protease	protease	NN
cord-001734-bbeznd3r	31	19	domain	domain	NN
cord-001734-bbeznd3r	31	20	by	by	IN
cord-001734-bbeznd3r	31	21	CD	CD	NNP
cord-001734-bbeznd3r	31	22	,	,	,
cord-001734-bbeznd3r	31	23	NMR	NMR	NNP
cord-001734-bbeznd3r	31	24	and	and	CC
cord-001734-bbeznd3r	31	25	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	31	26	relaxation	relaxation	NN
cord-001734-bbeznd3r	31	27	enhancement	enhancement	NN
cord-001734-bbeznd3r	31	28	(	(	-LRB-
cord-001734-bbeznd3r	31	29	PRE	PRE	NNP
cord-001734-bbeznd3r	31	30	)	)	-RRB-
cord-001734-bbeznd3r	31	31	.	.	.
cord-001734-bbeznd3r	32	1	The	the	DT
cord-001734-bbeznd3r	32	2	results	result	NNS
cord-001734-bbeznd3r	32	3	reveal	reveal	VBP
cord-001734-bbeznd3r	32	4	that	that	IN
cord-001734-bbeznd3r	32	5	surprisingly	surprisingly	RB
cord-001734-bbeznd3r	32	6	the	the	DT
cord-001734-bbeznd3r	32	7	isolated	isolated	JJ
cord-001734-bbeznd3r	32	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	32	9	domain	domain	NN
cord-001734-bbeznd3r	32	10	with	with	IN
cord-001734-bbeznd3r	32	11	the	the	DT
cord-001734-bbeznd3r	32	12	native	native	JJ
cord-001734-bbeznd3r	32	13	sequence	sequence	NN
cord-001734-bbeznd3r	32	14	is	be	VBZ
cord-001734-bbeznd3r	32	15	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	32	16	disordered	disordered	JJ
cord-001734-bbeznd3r	32	17	without	without	IN
cord-001734-bbeznd3r	32	18	any	any	DT
cord-001734-bbeznd3r	32	19	stable	stable	JJ
cord-001734-bbeznd3r	32	20	secondary	secondary	JJ
cord-001734-bbeznd3r	32	21	and	and	CC
cord-001734-bbeznd3r	32	22	tertiary	tertiary	JJ
cord-001734-bbeznd3r	32	23	structures	structure	NNS
cord-001734-bbeznd3r	32	24	,	,	,
cord-001734-bbeznd3r	32	25	as	as	RB
cord-001734-bbeznd3r	32	26	well	well	RB
cord-001734-bbeznd3r	32	27	as	as	IN
cord-001734-bbeznd3r	32	28	has	have	VBZ
cord-001734-bbeznd3r	32	29	no	no	DT
cord-001734-bbeznd3r	32	30	detectable	detectable	JJ
cord-001734-bbeznd3r	32	31	activity	activity	NN
cord-001734-bbeznd3r	32	32	.	.	.
cord-001734-bbeznd3r	33	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	33	2	,	,	,
cord-001734-bbeznd3r	33	3	upon	upon	IN
cord-001734-bbeznd3r	33	4	meeting	meet	VBG
cord-001734-bbeznd3r	33	5	the	the	DT
cord-001734-bbeznd3r	33	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	33	7	cofactor	cofactor	NN
cord-001734-bbeznd3r	33	8	,	,	,
cord-001734-bbeznd3r	33	9	the	the	DT
cord-001734-bbeznd3r	33	10	disordered	disordered	JJ
cord-001734-bbeznd3r	33	11	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	33	12	spontaneously	spontaneously	RB
cord-001734-bbeznd3r	33	13	folds	fold	VBZ
cord-001734-bbeznd3r	33	14	into	into	IN
cord-001734-bbeznd3r	33	15	the	the	DT
cord-001734-bbeznd3r	33	16	well	well	RB
cord-001734-bbeznd3r	33	17	-	-	HYPH
cord-001734-bbeznd3r	33	18	structured	structure	VBN
cord-001734-bbeznd3r	33	19	and	and	CC
cord-001734-bbeznd3r	33	20	active	active	JJ
cord-001734-bbeznd3r	33	21	enzyme	enzyme	NN
cord-001734-bbeznd3r	33	22	highly	highly	RB
cord-001734-bbeznd3r	33	23	similar	similar	JJ
cord-001734-bbeznd3r	33	24	to	to	IN
cord-001734-bbeznd3r	33	25	those	those	DT
cord-001734-bbeznd3r	33	26	co	co	NN
cord-001734-bbeznd3r	33	27	-	-	VBN
cord-001734-bbeznd3r	33	28	expressed	express	VBN
cord-001734-bbeznd3r	33	29	[	[	-LRB-
cord-001734-bbeznd3r	33	30	10	10	CD
cord-001734-bbeznd3r	33	31	,	,	,
cord-001734-bbeznd3r	33	32	11	11	CD
cord-001734-bbeznd3r	33	33	]	]	-RRB-
cord-001734-bbeznd3r	33	34	.	.	.
cord-001734-bbeznd3r	34	1	We	-PRON-	PRP
cord-001734-bbeznd3r	34	2	have	have	VBP
cord-001734-bbeznd3r	34	3	also	also	RB
cord-001734-bbeznd3r	34	4	successfully	successfully	RB
cord-001734-bbeznd3r	34	5	refolded	refolde	VBN
cord-001734-bbeznd3r	34	6	the	the	DT
cord-001734-bbeznd3r	34	7	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	34	8	complexed	complexed	JJ
cord-001734-bbeznd3r	34	9	with	with	IN
cord-001734-bbeznd3r	34	10	the	the	DT
cord-001734-bbeznd3r	34	11	full	full	JJ
cord-001734-bbeznd3r	34	12	-	-	HYPH
cord-001734-bbeznd3r	34	13	length	length	NN
cord-001734-bbeznd3r	34	14	NS2B	NS2B	NNP
cord-001734-bbeznd3r	34	15	anchored	anchor	VBN
cord-001734-bbeznd3r	34	16	into	into	IN
cord-001734-bbeznd3r	34	17	the	the	DT
cord-001734-bbeznd3r	34	18	LMPC	LMPC	NNP
cord-001734-bbeznd3r	34	19	micelle	micelle	NN
cord-001734-bbeznd3r	34	20	.	.	.
cord-001734-bbeznd3r	35	1	To	to	TO
cord-001734-bbeznd3r	35	2	further	further	RB
cord-001734-bbeznd3r	35	3	decipher	decipher	VB
cord-001734-bbeznd3r	35	4	the	the	DT
cord-001734-bbeznd3r	35	5	roles	role	NNS
cord-001734-bbeznd3r	35	6	of	of	IN
cord-001734-bbeznd3r	35	7	the	the	DT
cord-001734-bbeznd3r	35	8	NS2B	NS2B	NNP
cord-001734-bbeznd3r	35	9	cofactor	cofactor	NN
cord-001734-bbeznd3r	35	10	in	in	IN
cord-001734-bbeznd3r	35	11	protein	protein	NN
cord-001734-bbeznd3r	35	12	dynamics	dynamic	NNS
cord-001734-bbeznd3r	35	13	,	,	,
cord-001734-bbeznd3r	35	14	we	-PRON-	PRP
cord-001734-bbeznd3r	35	15	performed	perform	VBD
cord-001734-bbeznd3r	35	16	molecular	molecular	JJ
cord-001734-bbeznd3r	35	17	dynamics	dynamic	NNS
cord-001734-bbeznd3r	35	18	(	(	-LRB-
cord-001734-bbeznd3r	35	19	MD	MD	NNP
cord-001734-bbeznd3r	35	20	)	)	-RRB-
cord-001734-bbeznd3r	35	21	simulations	simulation	NNS
cord-001734-bbeznd3r	35	22	which	which	WDT
cord-001734-bbeznd3r	35	23	is	be	VBZ
cord-001734-bbeznd3r	35	24	very	very	RB
cord-001734-bbeznd3r	35	25	powerful	powerful	JJ
cord-001734-bbeznd3r	35	26	in	in	IN
cord-001734-bbeznd3r	35	27	pinpointing	pinpoint	VBG
cord-001734-bbeznd3r	35	28	the	the	DT
cord-001734-bbeznd3r	35	29	role	role	NN
cord-001734-bbeznd3r	35	30	of	of	IN
cord-001734-bbeznd3r	35	31	protein	protein	NN
cord-001734-bbeznd3r	35	32	dynamics	dynamic	NNS
cord-001734-bbeznd3r	35	33	in	in	IN
cord-001734-bbeznd3r	35	34	the	the	DT
cord-001734-bbeznd3r	35	35	catalysis	catalysis	NN
cord-001734-bbeznd3r	35	36	of	of	IN
cord-001734-bbeznd3r	35	37	proteases	protease	NNS
cord-001734-bbeznd3r	35	38	such	such	JJ
cord-001734-bbeznd3r	35	39	as	as	IN
cord-001734-bbeznd3r	35	40	the	the	DT
cord-001734-bbeznd3r	35	41	SARS	SARS	NNP
cord-001734-bbeznd3r	35	42	3C	3C	NNP
cord-001734-bbeznd3r	35	43	-	-	HYPH
cord-001734-bbeznd3r	35	44	like	like	JJ
cord-001734-bbeznd3r	35	45	protease	protease	NN
cord-001734-bbeznd3r	35	46	[	[	-LRB-
cord-001734-bbeznd3r	35	47	20	20	CD
cord-001734-bbeznd3r	35	48	,	,	,
cord-001734-bbeznd3r	35	49	21	21	CD
cord-001734-bbeznd3r	35	50	]	]	-RRB-
cord-001734-bbeznd3r	35	51	.	.	.
cord-001734-bbeznd3r	36	1	The	the	DT
cord-001734-bbeznd3r	36	2	correlation	correlation	NN
cord-001734-bbeznd3r	36	3	analysis	analysis	NN
cord-001734-bbeznd3r	36	4	reveals	reveal	VBZ
cord-001734-bbeznd3r	36	5	that	that	IN
cord-001734-bbeznd3r	36	6	the	the	DT
cord-001734-bbeznd3r	36	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	36	8	residues	residue	NNS
cord-001734-bbeznd3r	36	9	play	play	VBP
cord-001734-bbeznd3r	36	10	a	a	DT
cord-001734-bbeznd3r	36	11	central	central	JJ
cord-001734-bbeznd3r	36	12	role	role	NN
cord-001734-bbeznd3r	36	13	in	in	IN
cord-001734-bbeznd3r	36	14	coordinating	coordinate	VBG
cord-001734-bbeznd3r	36	15	the	the	DT
cord-001734-bbeznd3r	36	16	correlated	correlate	VBN
cord-001734-bbeznd3r	36	17	motion	motion	NN
cord-001734-bbeznd3r	36	18	network	network	NN
cord-001734-bbeznd3r	36	19	in	in	IN
cord-001734-bbeznd3r	36	20	the	the	DT
cord-001734-bbeznd3r	36	21	NS2B	NS2B	NNP
cord-001734-bbeznd3r	36	22	-	-	HYPH
cord-001734-bbeznd3r	36	23	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	36	24	complex	complex	NN
cord-001734-bbeznd3r	36	25	.	.	.
cord-001734-bbeznd3r	37	1	Indeed	indeed	RB
cord-001734-bbeznd3r	37	2	,	,	,
cord-001734-bbeznd3r	37	3	a	a	DT
cord-001734-bbeznd3r	37	4	truncated	truncated	JJ
cord-001734-bbeznd3r	37	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	37	6	is	be	VBZ
cord-001734-bbeznd3r	37	7	able	able	JJ
cord-001734-bbeznd3r	37	8	to	to	TO
cord-001734-bbeznd3r	37	9	form	form	VB
cord-001734-bbeznd3r	37	10	a	a	DT
cord-001734-bbeznd3r	37	11	buffer	buffer	NN
cord-001734-bbeznd3r	37	12	-	-	HYPH
cord-001734-bbeznd3r	37	13	soluble	soluble	JJ
cord-001734-bbeznd3r	37	14	complex	complex	NN
cord-001734-bbeznd3r	37	15	with	with	IN
cord-001734-bbeznd3r	37	16	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	37	17	,	,	,
cord-001734-bbeznd3r	37	18	but	but	CC
cord-001734-bbeznd3r	37	19	this	this	DT
cord-001734-bbeznd3r	37	20	complex	complex	NN
cord-001734-bbeznd3r	37	21	is	be	VBZ
cord-001734-bbeznd3r	37	22	highly	highly	RB
cord-001734-bbeznd3r	37	23	dynamic	dynamic	JJ
cord-001734-bbeznd3r	37	24	and	and	CC
cord-001734-bbeznd3r	37	25	catalytically	catalytically	RB
cord-001734-bbeznd3r	37	26	-	-	HYPH
cord-001734-bbeznd3r	37	27	impotent	impotent	JJ
cord-001734-bbeznd3r	37	28	.	.	.
cord-001734-bbeznd3r	38	1	Our	-PRON-	PRP$
cord-001734-bbeznd3r	38	2	results	result	NNS
cord-001734-bbeznd3r	38	3	imply	imply	VBP
cord-001734-bbeznd3r	38	4	that	that	IN
cord-001734-bbeznd3r	38	5	the	the	DT
cord-001734-bbeznd3r	38	6	discovery/	discovery/	CD
cord-001734-bbeznd3r	38	7	design	design	NN
cord-001734-bbeznd3r	38	8	of	of	IN
cord-001734-bbeznd3r	38	9	molecules	molecule	NNS
cord-001734-bbeznd3r	38	10	to	to	TO
cord-001734-bbeznd3r	38	11	block	block	VB
cord-001734-bbeznd3r	38	12	the	the	DT
cord-001734-bbeznd3r	38	13	correct	correct	JJ
cord-001734-bbeznd3r	38	14	folding	folding	NN
cord-001734-bbeznd3r	38	15	of	of	IN
cord-001734-bbeznd3r	38	16	the	the	DT
cord-001734-bbeznd3r	38	17	NS2B	NS2B	NNP
cord-001734-bbeznd3r	38	18	-	-	HYPH
cord-001734-bbeznd3r	38	19	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	38	20	complex	complex	NN
cord-001734-bbeznd3r	38	21	or	or	CC
cord-001734-bbeznd3r	38	22	/	/	SYM
cord-001734-bbeznd3r	38	23	and	and	CC
cord-001734-bbeznd3r	38	24	to	to	TO
cord-001734-bbeznd3r	38	25	decouple	decouple	VB
cord-001734-bbeznd3r	38	26	its	-PRON-	PRP$
cord-001734-bbeznd3r	38	27	correlated	correlate	VBN
cord-001734-bbeznd3r	38	28	motion	motion	NN
cord-001734-bbeznd3r	38	29	network	network	NN
cord-001734-bbeznd3r	38	30	might	may	MD
cord-001734-bbeznd3r	38	31	represent	represent	VB
cord-001734-bbeznd3r	38	32	promising	promising	JJ
cord-001734-bbeznd3r	38	33	strategies	strategy	NNS
cord-001734-bbeznd3r	38	34	to	to	TO
cord-001734-bbeznd3r	38	35	inhibit	inhibit	VB
cord-001734-bbeznd3r	38	36	the	the	DT
cord-001734-bbeznd3r	38	37	dengue	dengue	NN
cord-001734-bbeznd3r	38	38	protease	protease	NN
cord-001734-bbeznd3r	38	39	,	,	,
cord-001734-bbeznd3r	38	40	thus	thus	RB
cord-001734-bbeznd3r	38	41	holding	hold	VBG
cord-001734-bbeznd3r	38	42	the	the	DT
cord-001734-bbeznd3r	38	43	considerable	considerable	JJ
cord-001734-bbeznd3r	38	44	potential	potential	NN
cord-001734-bbeznd3r	38	45	to	to	TO
cord-001734-bbeznd3r	38	46	treat	treat	VB
cord-001734-bbeznd3r	38	47	dengue	dengue	NN
cord-001734-bbeznd3r	38	48	infections	infection	NNS
cord-001734-bbeznd3r	38	49	.	.	.
cord-001734-bbeznd3r	39	1	Plasmid	plasmid	NN
cord-001734-bbeznd3r	39	2	construction	construction	NN
cord-001734-bbeznd3r	39	3	DNA	dna	NN
cord-001734-bbeznd3r	39	4	sequences	sequence	NNS
cord-001734-bbeznd3r	39	5	encoding	encode	VBG
cord-001734-bbeznd3r	39	6	the	the	DT
cord-001734-bbeznd3r	39	7	NS3	ns3	JJ
cord-001734-bbeznd3r	39	8	protease	protease	NN
cord-001734-bbeznd3r	39	9	and	and	CC
cord-001734-bbeznd3r	39	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	39	11	from	from	IN
cord-001734-bbeznd3r	39	12	Dengue	Dengue	NNP
cord-001734-bbeznd3r	39	13	virus	virus	NN
cord-001734-bbeznd3r	39	14	type	type	NN
cord-001734-bbeznd3r	39	15	2	2	CD
cord-001734-bbeznd3r	39	16	strain	strain	NN
cord-001734-bbeznd3r	40	1	TSV01	TSV01	NNP
cord-001734-bbeznd3r	41	1	(	(	-LRB-
cord-001734-bbeznd3r	41	2	GenBank	GenBank	NNP
cord-001734-bbeznd3r	41	3	accession	accession	NN
cord-001734-bbeznd3r	41	4	number	number	NN
cord-001734-bbeznd3r	42	1	AY037116	AY037116	NNP
cord-001734-bbeznd3r	42	2	)	)	-RRB-
cord-001734-bbeznd3r	42	3	were	be	VBD
cord-001734-bbeznd3r	42	4	optimized	optimize	VBN
cord-001734-bbeznd3r	42	5	and	and	CC
cord-001734-bbeznd3r	42	6	synthesized	synthesize	VBN
cord-001734-bbeznd3r	42	7	by	by	IN
cord-001734-bbeznd3r	42	8	GenScript	GenScript	NNP
cord-001734-bbeznd3r	42	9	(	(	-LRB-
cord-001734-bbeznd3r	42	10	Piscataway	Piscataway	NNP
cord-001734-bbeznd3r	42	11	,	,	,
cord-001734-bbeznd3r	42	12	NJ	NJ	NNP
cord-001734-bbeznd3r	42	13	)	)	-RRB-
cord-001734-bbeznd3r	42	14	.	.	.
cord-001734-bbeznd3r	43	1	With	with	IN
cord-001734-bbeznd3r	43	2	designed	design	VBN
cord-001734-bbeznd3r	43	3	primers	primer	NNS
cord-001734-bbeznd3r	43	4	,	,	,
cord-001734-bbeznd3r	43	5	the	the	DT
cord-001734-bbeznd3r	43	6	optimized	optimize	VBN
cord-001734-bbeznd3r	43	7	DNA	DNA	NNP
cord-001734-bbeznd3r	43	8	by	by	IN
cord-001734-bbeznd3r	43	9	GenScript	GenScript	NNP
cord-001734-bbeznd3r	43	10	were	be	VBD
cord-001734-bbeznd3r	43	11	used	use	VBN
cord-001734-bbeznd3r	43	12	as	as	IN
cord-001734-bbeznd3r	43	13	templates	template	NNS
cord-001734-bbeznd3r	43	14	for	for	IN
cord-001734-bbeznd3r	43	15	amplifying	amplify	VBG
cord-001734-bbeznd3r	43	16	the	the	DT
cord-001734-bbeznd3r	43	17	DNA	dna	NN
cord-001734-bbeznd3r	43	18	fragments	fragment	NNS
cord-001734-bbeznd3r	43	19	encoding	encode	VBG
cord-001734-bbeznd3r	43	20	residues	residue	NNS
cord-001734-bbeznd3r	43	21	14	14	CD
cord-001734-bbeznd3r	43	22	-	-	SYM
cord-001734-bbeznd3r	43	23	185	185	CD
cord-001734-bbeznd3r	43	24	of	of	IN
cord-001734-bbeznd3r	43	25	NS3pro	NS3pro	NNS
cord-001734-bbeznd3r	43	26	and	and	CC
cord-001734-bbeznd3r	43	27	residues	residue	NNS
cord-001734-bbeznd3r	43	28	48	48	CD
cord-001734-bbeznd3r	43	29	-	-	SYM
cord-001734-bbeznd3r	43	30	100	100	CD
cord-001734-bbeznd3r	43	31	of	of	IN
cord-001734-bbeznd3r	43	32	NS2B	NS2B	NNP
cord-001734-bbeznd3r	43	33	,	,	,
cord-001734-bbeznd3r	43	34	which	which	WDT
cord-001734-bbeznd3r	43	35	have	have	VBP
cord-001734-bbeznd3r	43	36	the	the	DT
cord-001734-bbeznd3r	43	37	same	same	JJ
cord-001734-bbeznd3r	43	38	starting	starting	NN
cord-001734-bbeznd3r	43	39	and	and	CC
cord-001734-bbeznd3r	43	40	ending	end	VBG
cord-001734-bbeznd3r	43	41	residues	residue	NNS
cord-001734-bbeznd3r	43	42	as	as	IN
cord-001734-bbeznd3r	43	43	the	the	DT
cord-001734-bbeznd3r	43	44	constructs	construct	NNS
cord-001734-bbeznd3r	43	45	used	use	VBN
cord-001734-bbeznd3r	43	46	in	in	IN
cord-001734-bbeznd3r	43	47	the	the	DT
cord-001734-bbeznd3r	43	48	previous	previous	JJ
cord-001734-bbeznd3r	43	49	NMR	NMR	NNP
cord-001734-bbeznd3r	43	50	study	study	NN
cord-001734-bbeznd3r	43	51	[	[	-LRB-
cord-001734-bbeznd3r	43	52	10	10	CD
cord-001734-bbeznd3r	43	53	]	]	-RRB-
cord-001734-bbeznd3r	43	54	,	,	,
cord-001734-bbeznd3r	43	55	as	as	RB
cord-001734-bbeznd3r	43	56	well	well	RB
cord-001734-bbeznd3r	43	57	as	as	IN
cord-001734-bbeznd3r	43	58	the	the	DT
cord-001734-bbeznd3r	43	59	full	full	JJ
cord-001734-bbeznd3r	43	60	-	-	HYPH
cord-001734-bbeznd3r	43	61	length	length	NN
cord-001734-bbeznd3r	43	62	NS2B	NS2B	NNP
cord-001734-bbeznd3r	43	63	over	over	IN
cord-001734-bbeznd3r	43	64	residues	residue	NNS
cord-001734-bbeznd3r	43	65	1	1	CD
cord-001734-bbeznd3r	43	66	-	-	SYM
cord-001734-bbeznd3r	43	67	130	130	CD
cord-001734-bbeznd3r	43	68	including	include	VBG
cord-001734-bbeznd3r	43	69	the	the	DT
cord-001734-bbeznd3r	43	70	N	N	NNP
cord-001734-bbeznd3r	43	71	-	-	HYPH
cord-001734-bbeznd3r	43	72	and	and	CC
cord-001734-bbeznd3r	43	73	C	C	NNP
cord-001734-bbeznd3r	43	74	-	-	HYPH
cord-001734-bbeznd3r	43	75	terminal	terminal	NN
cord-001734-bbeznd3r	43	76	transmembrane	transmembrane	NN
cord-001734-bbeznd3r	43	77	domains	domain	NNS
cord-001734-bbeznd3r	43	78	.	.	.
cord-001734-bbeznd3r	44	1	Amplified	amplify	VBN
cord-001734-bbeznd3r	44	2	DNA	dna	NN
cord-001734-bbeznd3r	44	3	fragments	fragment	NNS
cord-001734-bbeznd3r	44	4	for	for	IN
cord-001734-bbeznd3r	44	5	NS3	ns3	RB
cord-001734-bbeznd3r	44	6	(	(	-LRB-
cord-001734-bbeznd3r	44	7	14	14	CD
cord-001734-bbeznd3r	44	8	-	-	SYM
cord-001734-bbeznd3r	44	9	185	185	CD
cord-001734-bbeznd3r	44	10	)	)	-RRB-
cord-001734-bbeznd3r	44	11	,	,	.
cord-001734-bbeznd3r	45	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	45	2	(	(	-LRB-
cord-001734-bbeznd3r	45	3	1	1	CD
cord-001734-bbeznd3r	45	4	-	-	SYM
cord-001734-bbeznd3r	45	5	130	130	CD
cord-001734-bbeznd3r	45	6	)	)	-RRB-
cord-001734-bbeznd3r	45	7	and	and	CC
cord-001734-bbeznd3r	45	8	were	be	VBD
cord-001734-bbeznd3r	45	9	subsequently	subsequently	RB
cord-001734-bbeznd3r	45	10	cloned	clone	VBN
cord-001734-bbeznd3r	45	11	into	into	IN
cord-001734-bbeznd3r	45	12	pET28a	pet28a	JJ
cord-001734-bbeznd3r	45	13	vector	vector	NN
cord-001734-bbeznd3r	45	14	with	with	IN
cord-001734-bbeznd3r	45	15	N	n	CD
cord-001734-bbeznd3r	45	16	-	-	HYPH
cord-001734-bbeznd3r	45	17	terminal	terminal	NN
cord-001734-bbeznd3r	45	18	His	-PRON-	PRP$
cord-001734-bbeznd3r	45	19	-	-	HYPH
cord-001734-bbeznd3r	45	20	tag	tag	NN
cord-001734-bbeznd3r	45	21	(	(	-LRB-
cord-001734-bbeznd3r	45	22	Novagen	Novagen	NNP
cord-001734-bbeznd3r	45	23	)	)	-RRB-
cord-001734-bbeznd3r	45	24	using	use	VBG
cord-001734-bbeznd3r	45	25	NcoI	NcoI	NNP
cord-001734-bbeznd3r	45	26	and	and	CC
cord-001734-bbeznd3r	45	27	XhoI	XhoI	NNP
cord-001734-bbeznd3r	45	28	restriction	restriction	NN
cord-001734-bbeznd3r	45	29	sites	site	NNS
cord-001734-bbeznd3r	45	30	,	,	,
cord-001734-bbeznd3r	45	31	while	while	IN
cord-001734-bbeznd3r	45	32	fragments	fragment	NNS
cord-001734-bbeznd3r	45	33	for	for	IN
cord-001734-bbeznd3r	45	34	NS2B	NS2B	NNP
cord-001734-bbeznd3r	45	35	(	(	-LRB-
cord-001734-bbeznd3r	45	36	48	48	CD
cord-001734-bbeznd3r	45	37	-	-	SYM
cord-001734-bbeznd3r	45	38	100	100	CD
cord-001734-bbeznd3r	45	39	)	)	-RRB-
cord-001734-bbeznd3r	45	40	and	and	CC
cord-001734-bbeznd3r	45	41	NS2B	NS2B	NNP
cord-001734-bbeznd3r	45	42	(	(	-LRB-
cord-001734-bbeznd3r	45	43	48	48	CD
cord-001734-bbeznd3r	45	44	-	-	SYM
cord-001734-bbeznd3r	45	45	100	100	CD
cord-001734-bbeznd3r	45	46	;	;	:
cord-001734-bbeznd3r	45	47	Δ77	Δ77	NNP
cord-001734-bbeznd3r	45	48	-	-	HYPH
cord-001734-bbeznd3r	45	49	84	84	CD
cord-001734-bbeznd3r	45	50	)	)	-RRB-
cord-001734-bbeznd3r	45	51	with	with	IN
cord-001734-bbeznd3r	45	52	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	45	53	replaced	replace	VBN
cord-001734-bbeznd3r	45	54	by	by	IN
cord-001734-bbeznd3r	45	55	three	three	CD
cord-001734-bbeznd3r	45	56	Gly	Gly	NNP
cord-001734-bbeznd3r	45	57	residues	residue	NNS
cord-001734-bbeznd3r	45	58	were	be	VBD
cord-001734-bbeznd3r	45	59	cloned	clone	VBN
cord-001734-bbeznd3r	45	60	into	into	IN
cord-001734-bbeznd3r	45	61	pGEX-4T1	pgex-4t1	JJ
cord-001734-bbeznd3r	45	62	vector	vector	NN
cord-001734-bbeznd3r	45	63	with	with	IN
cord-001734-bbeznd3r	45	64	GST	gst	NN
cord-001734-bbeznd3r	45	65	-	-	HYPH
cord-001734-bbeznd3r	45	66	tag	tag	NN
cord-001734-bbeznd3r	45	67	(	(	-LRB-
cord-001734-bbeznd3r	45	68	GE	GE	NNP
cord-001734-bbeznd3r	45	69	healthcare	healthcare	NN
cord-001734-bbeznd3r	45	70	)	)	-RRB-
cord-001734-bbeznd3r	45	71	using	use	VBG
cord-001734-bbeznd3r	45	72	BamHI	BamHI	NNP
cord-001734-bbeznd3r	45	73	and	and	CC
cord-001734-bbeznd3r	45	74	XhoI	XhoI	NNP
cord-001734-bbeznd3r	45	75	restriction	restriction	NN
cord-001734-bbeznd3r	45	76	sites	site	NNS
cord-001734-bbeznd3r	45	77	.	.	.
cord-001734-bbeznd3r	46	1	DNA	dna	NN
cord-001734-bbeznd3r	46	2	sequences	sequence	NNS
cord-001734-bbeznd3r	46	3	of	of	IN
cord-001734-bbeznd3r	46	4	cloned	clone	VBN
cord-001734-bbeznd3r	46	5	constructs	construct	NNS
cord-001734-bbeznd3r	46	6	were	be	VBD
cord-001734-bbeznd3r	46	7	verified	verify	VBN
cord-001734-bbeznd3r	46	8	by	by	IN
cord-001734-bbeznd3r	46	9	automated	automate	VBN
cord-001734-bbeznd3r	46	10	DNA	dna	NN
cord-001734-bbeznd3r	46	11	sequencing	sequencing	NN
cord-001734-bbeznd3r	46	12	.	.	.
cord-001734-bbeznd3r	47	1	Competent	competent	JJ
cord-001734-bbeznd3r	47	2	Escherichia	Escherichia	NNP
cord-001734-bbeznd3r	47	3	coli	coli	NNS
cord-001734-bbeznd3r	48	1	BL21	BL21	NNP
cord-001734-bbeznd3r	48	2	(	(	-LRB-
cord-001734-bbeznd3r	48	3	DE3	DE3	NNP
cord-001734-bbeznd3r	48	4	)	)	-RRB-
cord-001734-bbeznd3r	48	5	Star	Star	NNP
cord-001734-bbeznd3r	48	6	cells	cell	NNS
cord-001734-bbeznd3r	48	7	were	be	VBD
cord-001734-bbeznd3r	48	8	transformed	transform	VBN
cord-001734-bbeznd3r	48	9	with	with	IN
cord-001734-bbeznd3r	48	10	pET28a	pet28a	JJ
cord-001734-bbeznd3r	48	11	-	-	HYPH
cord-001734-bbeznd3r	48	12	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	48	13	or	or	CC
cord-001734-bbeznd3r	48	14	pGEX-4T1-NS2B	pGEX-4T1-NS2B	NNP
cord-001734-bbeznd3r	48	15	plasmids	plasmid	NNS
cord-001734-bbeznd3r	48	16	.	.	.
cord-001734-bbeznd3r	49	1	Transformed	transform	VBN
cord-001734-bbeznd3r	49	2	single	single	JJ
cord-001734-bbeznd3r	49	3	colony	colony	NN
cord-001734-bbeznd3r	49	4	was	be	VBD
cord-001734-bbeznd3r	49	5	inoculated	inoculate	VBN
cord-001734-bbeznd3r	49	6	overnight	overnight	RB
cord-001734-bbeznd3r	49	7	in	in	IN
cord-001734-bbeznd3r	49	8	10	10	CD
cord-001734-bbeznd3r	49	9	ml	ml	NNP
cord-001734-bbeznd3r	49	10	Luria	Luria	NNP
cord-001734-bbeznd3r	49	11	-	-	HYPH
cord-001734-bbeznd3r	49	12	Bertani	Bertani	NNP
cord-001734-bbeznd3r	49	13	broth	broth	NN
cord-001734-bbeznd3r	49	14	containing	contain	VBG
cord-001734-bbeznd3r	49	15	25	25	CD
cord-001734-bbeznd3r	49	16	μg	μg	NNS
cord-001734-bbeznd3r	49	17	/	/	SYM
cord-001734-bbeznd3r	49	18	ml	ml	IN
cord-001734-bbeznd3r	49	19	kanamycin	kanamycin	NNP
cord-001734-bbeznd3r	49	20	for	for	IN
cord-001734-bbeznd3r	49	21	pET28a	pET28a	NNP
cord-001734-bbeznd3r	49	22	and	and	CC
cord-001734-bbeznd3r	49	23	100	100	CD
cord-001734-bbeznd3r	49	24	μg	μg	NN
cord-001734-bbeznd3r	49	25	/	/	SYM
cord-001734-bbeznd3r	49	26	ml	ml	XX
cord-001734-bbeznd3r	49	27	ampicillin	ampicillin	NN
cord-001734-bbeznd3r	49	28	for	for	IN
cord-001734-bbeznd3r	49	29	pGEX-4T1	pGEX-4T1	NNP
cord-001734-bbeznd3r	49	30	.	.	.
cord-001734-bbeznd3r	50	1	Then	then	RB
cord-001734-bbeznd3r	50	2	cells	cell	NNS
cord-001734-bbeznd3r	50	3	were	be	VBD
cord-001734-bbeznd3r	50	4	transferred	transfer	VBN
cord-001734-bbeznd3r	50	5	to	to	IN
cord-001734-bbeznd3r	50	6	1	1	CD
cord-001734-bbeznd3r	50	7	lit	light	VBD
cord-001734-bbeznd3r	50	8	LB	LB	NNP
cord-001734-bbeznd3r	50	9	media	medium	NNS
cord-001734-bbeznd3r	50	10	containing	contain	VBG
cord-001734-bbeznd3r	50	11	respective	respective	JJ
cord-001734-bbeznd3r	50	12	antibiotics	antibiotic	NNS
cord-001734-bbeznd3r	50	13	and	and	CC
cord-001734-bbeznd3r	50	14	grown	grow	VBN
cord-001734-bbeznd3r	50	15	at	at	IN
cord-001734-bbeznd3r	50	16	37	37	CD
cord-001734-bbeznd3r	50	17	°	°	NN
cord-001734-bbeznd3r	50	18	C	c	NN
cord-001734-bbeznd3r	50	19	with	with	IN
cord-001734-bbeznd3r	50	20	shaking	shake	VBG
cord-001734-bbeznd3r	50	21	until	until	IN
cord-001734-bbeznd3r	50	22	the	the	DT
cord-001734-bbeznd3r	50	23	A	A	NNP
cord-001734-bbeznd3r	50	24	600	600	CD
cord-001734-bbeznd3r	50	25	reached	reach	VBD
cord-001734-bbeznd3r	50	26	to	to	IN
cord-001734-bbeznd3r	50	27	0.6	0.6	CD
cord-001734-bbeznd3r	50	28	.	.	.
cord-001734-bbeznd3r	51	1	Cultures	culture	NNS
cord-001734-bbeznd3r	51	2	were	be	VBD
cord-001734-bbeznd3r	51	3	induced	induce	VBN
cord-001734-bbeznd3r	51	4	with	with	IN
cord-001734-bbeznd3r	51	5	0.5	0.5	CD
cord-001734-bbeznd3r	51	6	mM	mm	CD
cord-001734-bbeznd3r	51	7	isopropyl	isopropyl	NN
cord-001734-bbeznd3r	51	8	β	β	NN
cord-001734-bbeznd3r	51	9	-	-	HYPH
cord-001734-bbeznd3r	51	10	D	D	NNP
cord-001734-bbeznd3r	51	11	-	-	HYPH
cord-001734-bbeznd3r	51	12	thiogalactopyranoside	thiogalactopyranoside	NN
cord-001734-bbeznd3r	51	13	(	(	-LRB-
cord-001734-bbeznd3r	51	14	IPTG	IPTG	NNP
cord-001734-bbeznd3r	51	15	)	)	-RRB-
cord-001734-bbeznd3r	51	16	for	for	IN
cord-001734-bbeznd3r	51	17	16	16	CD
cord-001734-bbeznd3r	51	18	h	h	NN
cord-001734-bbeznd3r	51	19	at	at	IN
cord-001734-bbeznd3r	51	20	20	20	CD
cord-001734-bbeznd3r	51	21	°	°	NN
cord-001734-bbeznd3r	51	22	C	c	NN
cord-001734-bbeznd3r	51	23	.	.	.
cord-001734-bbeznd3r	52	1	Cells	cell	NNS
cord-001734-bbeznd3r	52	2	were	be	VBD
cord-001734-bbeznd3r	52	3	harvested	harvest	VBN
cord-001734-bbeznd3r	52	4	and	and	CC
cord-001734-bbeznd3r	52	5	resuspended	resuspend	VBN
cord-001734-bbeznd3r	52	6	in	in	IN
cord-001734-bbeznd3r	52	7	cold	cold	JJ
cord-001734-bbeznd3r	52	8	Phosphate	Phosphate	NNP
cord-001734-bbeznd3r	52	9	Buffered	buffer	VBN
cord-001734-bbeznd3r	52	10	Saline	Saline	NNP
cord-001734-bbeznd3r	52	11	(	(	-LRB-
cord-001734-bbeznd3r	52	12	PBS	PBS	NNP
cord-001734-bbeznd3r	52	13	)	)	-RRB-
cord-001734-bbeznd3r	52	14	pH	ph	NN
cord-001734-bbeznd3r	52	15	7.4	7.4	CD
cord-001734-bbeznd3r	52	16	buffer	buffer	NN
cord-001734-bbeznd3r	52	17	for	for	IN
cord-001734-bbeznd3r	52	18	lysis	lysis	NN
cord-001734-bbeznd3r	52	19	by	by	IN
cord-001734-bbeznd3r	52	20	sonication	sonication	NN
cord-001734-bbeznd3r	52	21	.	.	.
cord-001734-bbeznd3r	53	1	After	after	IN
cord-001734-bbeznd3r	53	2	centrifugation	centrifugation	NN
cord-001734-bbeznd3r	53	3	at	at	IN
cord-001734-bbeznd3r	53	4	40000	40000	CD
cord-001734-bbeznd3r	53	5	g	g	NN
cord-001734-bbeznd3r	53	6	,	,	,
cord-001734-bbeznd3r	53	7	GST	GST	NNP
cord-001734-bbeznd3r	53	8	-	-	HYPH
cord-001734-bbeznd3r	53	9	tagged	tag	VBN
cord-001734-bbeznd3r	53	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	53	11	(	(	-LRB-
cord-001734-bbeznd3r	53	12	48	48	CD
cord-001734-bbeznd3r	53	13	-	-	SYM
cord-001734-bbeznd3r	53	14	100	100	CD
cord-001734-bbeznd3r	53	15	)	)	-RRB-
cord-001734-bbeznd3r	53	16	protein	protein	NN
cord-001734-bbeznd3r	53	17	was	be	VBD
cord-001734-bbeznd3r	53	18	purified	purify	VBN
cord-001734-bbeznd3r	53	19	from	from	IN
cord-001734-bbeznd3r	53	20	supernatant	supernatant	JJ
cord-001734-bbeznd3r	53	21	using	use	VBG
cord-001734-bbeznd3r	53	22	affinity	affinity	NN
cord-001734-bbeznd3r	53	23	chromatography	chromatography	NN
cord-001734-bbeznd3r	53	24	.	.	.
cord-001734-bbeznd3r	54	1	The	the	DT
cord-001734-bbeznd3r	54	2	GST	GST	NNP
cord-001734-bbeznd3r	54	3	-	-	HYPH
cord-001734-bbeznd3r	54	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	54	5	(	(	-LRB-
cord-001734-bbeznd3r	54	6	48	48	CD
cord-001734-bbeznd3r	54	7	-	-	SYM
cord-001734-bbeznd3r	54	8	100	100	CD
cord-001734-bbeznd3r	54	9	)	)	-RRB-
cord-001734-bbeznd3r	54	10	protein	protein	NN
cord-001734-bbeznd3r	54	11	was	be	VBD
cord-001734-bbeznd3r	54	12	cleaved	cleave	VBN
cord-001734-bbeznd3r	54	13	with	with	IN
cord-001734-bbeznd3r	54	14	thrombin	thrombin	NN
cord-001734-bbeznd3r	54	15	to	to	TO
cord-001734-bbeznd3r	54	16	remove	remove	VB
cord-001734-bbeznd3r	54	17	the	the	DT
cord-001734-bbeznd3r	54	18	GST	gst	NN
cord-001734-bbeznd3r	54	19	tag	tag	NN
cord-001734-bbeznd3r	54	20	,	,	,
cord-001734-bbeznd3r	54	21	and	and	CC
cord-001734-bbeznd3r	54	22	the	the	DT
cord-001734-bbeznd3r	54	23	released	release	VBN
cord-001734-bbeznd3r	54	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	54	25	peptide	peptide	NN
cord-001734-bbeznd3r	54	26	was	be	VBD
cord-001734-bbeznd3r	54	27	further	further	RB
cord-001734-bbeznd3r	54	28	purified	purify	VBN
cord-001734-bbeznd3r	54	29	by	by	IN
cord-001734-bbeznd3r	54	30	RP	RP	NNP
cord-001734-bbeznd3r	54	31	-	-	HYPH
cord-001734-bbeznd3r	54	32	HPLC	HPLC	NNP
cord-001734-bbeznd3r	54	33	on	on	IN
cord-001734-bbeznd3r	54	34	a	a	DT
cord-001734-bbeznd3r	54	35	Vydac	Vydac	NNP
cord-001734-bbeznd3r	54	36	C	C	NNP
cord-001734-bbeznd3r	54	37	8	8	CD
cord-001734-bbeznd3r	54	38	column	column	NN
cord-001734-bbeznd3r	54	39	.	.	.
cord-001734-bbeznd3r	55	1	The	the	DT
cord-001734-bbeznd3r	55	2	NS2B	NS2B	NNP
cord-001734-bbeznd3r	55	3	(	(	-LRB-
cord-001734-bbeznd3r	55	4	1	1	CD
cord-001734-bbeznd3r	55	5	-	-	SYM
cord-001734-bbeznd3r	55	6	130	130	CD
cord-001734-bbeznd3r	55	7	)	)	-RRB-
cord-001734-bbeznd3r	55	8	and	and	CC
cord-001734-bbeznd3r	55	9	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	55	10	proteins	protein	NNS
cord-001734-bbeznd3r	55	11	were	be	VBD
cord-001734-bbeznd3r	55	12	completely	completely	RB
cord-001734-bbeznd3r	55	13	insoluble	insoluble	JJ
cord-001734-bbeznd3r	55	14	and	and	CC
cord-001734-bbeznd3r	55	15	all	all	DT
cord-001734-bbeznd3r	55	16	found	find	VBN
cord-001734-bbeznd3r	55	17	in	in	IN
cord-001734-bbeznd3r	55	18	inclusion	inclusion	NN
cord-001734-bbeznd3r	55	19	body	body	NN
cord-001734-bbeznd3r	55	20	,	,	,
cord-001734-bbeznd3r	55	21	which	which	WDT
cord-001734-bbeznd3r	55	22	were	be	VBD
cord-001734-bbeznd3r	55	23	solubilized	solubilize	VBN
cord-001734-bbeznd3r	55	24	with	with	IN
cord-001734-bbeznd3r	55	25	PBS	PBS	NNP
cord-001734-bbeznd3r	55	26	buffer	buffer	NN
cord-001734-bbeznd3r	55	27	(	(	-LRB-
cord-001734-bbeznd3r	55	28	pH7.4	pH7.4	NNP
cord-001734-bbeznd3r	55	29	)	)	-RRB-
cord-001734-bbeznd3r	55	30	containing	contain	VBG
cord-001734-bbeznd3r	55	31	8	8	CD
cord-001734-bbeznd3r	55	32	M	M	NNP
cord-001734-bbeznd3r	55	33	urea	urea	NN
cord-001734-bbeznd3r	55	34	.	.	.
cord-001734-bbeznd3r	56	1	Cell	cell	NN
cord-001734-bbeznd3r	56	2	debris	debris	NN
cord-001734-bbeznd3r	56	3	was	be	VBD
cord-001734-bbeznd3r	56	4	removed	remove	VBN
cord-001734-bbeznd3r	56	5	by	by	IN
cord-001734-bbeznd3r	56	6	centrifugation	centrifugation	NN
cord-001734-bbeznd3r	56	7	at	at	IN
cord-001734-bbeznd3r	56	8	40000	40000	CD
cord-001734-bbeznd3r	56	9	g	g	NN
cord-001734-bbeznd3r	56	10	,	,	,
cord-001734-bbeznd3r	56	11	and	and	CC
cord-001734-bbeznd3r	56	12	supernatant	supernatant	JJ
cord-001734-bbeznd3r	56	13	containing	contain	VBG
cord-001734-bbeznd3r	56	14	His	-PRON-	PRP$
cord-001734-bbeznd3r	56	15	-	-	HYPH
cord-001734-bbeznd3r	56	16	tagged	tag	VBN
cord-001734-bbeznd3r	56	17	NS2B	NS2B	NNP
cord-001734-bbeznd3r	56	18	(	(	-LRB-
cord-001734-bbeznd3r	56	19	1	1	CD
cord-001734-bbeznd3r	56	20	-	-	SYM
cord-001734-bbeznd3r	56	21	130	130	CD
cord-001734-bbeznd3r	56	22	)	)	-RRB-
cord-001734-bbeznd3r	56	23	and	and	CC
cord-001734-bbeznd3r	56	24	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	56	25	were	be	VBD
cord-001734-bbeznd3r	56	26	purified	purify	VBN
cord-001734-bbeznd3r	56	27	by	by	IN
cord-001734-bbeznd3r	56	28	Ni	Ni	NNP
cord-001734-bbeznd3r	56	29	-	-	HYPH
cord-001734-bbeznd3r	56	30	NTA	NTA	NNP
cord-001734-bbeznd3r	56	31	affinity	affinity	NN
cord-001734-bbeznd3r	56	32	chromatography	chromatography	NN
cord-001734-bbeznd3r	56	33	under	under	IN
cord-001734-bbeznd3r	56	34	denaturing	denature	VBG
cord-001734-bbeznd3r	56	35	condition	condition	NN
cord-001734-bbeznd3r	56	36	.	.	.
cord-001734-bbeznd3r	57	1	Eluted	Eluted	NNP
cord-001734-bbeznd3r	57	2	protein	protein	NN
cord-001734-bbeznd3r	57	3	was	be	VBD
cord-001734-bbeznd3r	57	4	further	further	RB
cord-001734-bbeznd3r	57	5	purified	purify	VBN
cord-001734-bbeznd3r	57	6	with	with	IN
cord-001734-bbeznd3r	57	7	RP	RP	NNP
cord-001734-bbeznd3r	57	8	-	-	HYPH
cord-001734-bbeznd3r	57	9	HPLC	HPLC	NNP
cord-001734-bbeznd3r	57	10	on	on	IN
cord-001734-bbeznd3r	57	11	a	a	DT
cord-001734-bbeznd3r	57	12	Vydac	Vydac	NNP
cord-001734-bbeznd3r	57	13	C	C	NNP
cord-001734-bbeznd3r	57	14	8	8	CD
cord-001734-bbeznd3r	57	15	column	column	NN
cord-001734-bbeznd3r	57	16	.	.	.
cord-001734-bbeznd3r	58	1	(	(	-LRB-
cord-001734-bbeznd3r	58	2	15	15	CD
cord-001734-bbeznd3r	58	3	NH	NH	NNP
cord-001734-bbeznd3r	58	4	4	4	CD
cord-001734-bbeznd3r	58	5	)	)	-RRB-
cord-001734-bbeznd3r	58	6	2	2	CD
cord-001734-bbeznd3r	58	7	SO	so	IN
cord-001734-bbeznd3r	58	8	4	4	CD
cord-001734-bbeznd3r	58	9	,	,	,
cord-001734-bbeznd3r	58	10	[	[	-LRB-
cord-001734-bbeznd3r	58	11	13	13	CD
cord-001734-bbeznd3r	58	12	C6]-glucose	C6]-glucose	NNP
cord-001734-bbeznd3r	58	13	and	and	CC
cord-001734-bbeznd3r	58	14	D	d	NN
cord-001734-bbeznd3r	58	15	2	2	CD
cord-001734-bbeznd3r	59	1	O	o	UH
cord-001734-bbeznd3r	59	2	were	be	VBD
cord-001734-bbeznd3r	59	3	purchased	purchase	VBN
cord-001734-bbeznd3r	59	4	from	from	IN
cord-001734-bbeznd3r	59	5	Cambridge	Cambridge	NNP
cord-001734-bbeznd3r	59	6	Isotope	Isotope	NNP
cord-001734-bbeznd3r	59	7	Laboratories	Laboratories	NNP
cord-001734-bbeznd3r	59	8	(	(	-LRB-
cord-001734-bbeznd3r	59	9	Andover	Andover	NNP
cord-001734-bbeznd3r	59	10	,	,	,
cord-001734-bbeznd3r	59	11	MA	MA	NNP
cord-001734-bbeznd3r	59	12	)	)	-RRB-
cord-001734-bbeznd3r	59	13	.	.	.
cord-001734-bbeznd3r	60	1	The	the	DT
cord-001734-bbeznd3r	60	2	generation	generation	NN
cord-001734-bbeznd3r	60	3	of	of	IN
cord-001734-bbeznd3r	60	4	the	the	DT
cord-001734-bbeznd3r	60	5	isotope	isotope	NN
cord-001734-bbeznd3r	60	6	-	-	HYPH
cord-001734-bbeznd3r	60	7	labeled	label	VBN
cord-001734-bbeznd3r	60	8	proteins	protein	NNS
cord-001734-bbeznd3r	60	9	for	for	IN
cord-001734-bbeznd3r	60	10	NMR	NMR	NNP
cord-001734-bbeznd3r	60	11	studies	study	NNS
cord-001734-bbeznd3r	60	12	followed	follow	VBD
cord-001734-bbeznd3r	60	13	a	a	DT
cord-001734-bbeznd3r	60	14	similar	similar	JJ
cord-001734-bbeznd3r	60	15	procedure	procedure	NN
cord-001734-bbeznd3r	60	16	except	except	IN
cord-001734-bbeznd3r	60	17	that	that	IN
cord-001734-bbeznd3r	60	18	the	the	DT
cord-001734-bbeznd3r	60	19	bacteria	bacteria	NNS
cord-001734-bbeznd3r	60	20	were	be	VBD
cord-001734-bbeznd3r	60	21	grown	grow	VBN
cord-001734-bbeznd3r	60	22	in	in	IN
cord-001734-bbeznd3r	60	23	M9	M9	NNP
cord-001734-bbeznd3r	60	24	medium	medium	NN
cord-001734-bbeznd3r	60	25	with	with	IN
cord-001734-bbeznd3r	60	26	the	the	DT
cord-001734-bbeznd3r	60	27	addition	addition	NN
cord-001734-bbeznd3r	60	28	of	of	IN
cord-001734-bbeznd3r	60	29	(	(	-LRB-
cord-001734-bbeznd3r	60	30	15	15	CD
cord-001734-bbeznd3r	60	31	NH	NH	NNP
cord-001734-bbeznd3r	60	32	4	4	CD
cord-001734-bbeznd3r	60	33	)	)	-RRB-
cord-001734-bbeznd3r	60	34	2	2	CD
cord-001734-bbeznd3r	60	35	SO	so	NN
cord-001734-bbeznd3r	60	36	4	4	CD
cord-001734-bbeznd3r	60	37	for	for	IN
cord-001734-bbeznd3r	60	38	15	15	CD
cord-001734-bbeznd3r	60	39	N	n	CD
cord-001734-bbeznd3r	60	40	labeling	labeling	NN
cord-001734-bbeznd3r	60	41	and	and	CC
cord-001734-bbeznd3r	60	42	(	(	-LRB-
cord-001734-bbeznd3r	60	43	15	15	CD
cord-001734-bbeznd3r	60	44	NH	NH	NNP
cord-001734-bbeznd3r	60	45	4	4	CD
cord-001734-bbeznd3r	60	46	)	)	-RRB-
cord-001734-bbeznd3r	60	47	2	2	CD
cord-001734-bbeznd3r	61	1	SO	so	RB
cord-001734-bbeznd3r	61	2	4	4	CD
cord-001734-bbeznd3r	61	3	/	/	SYM
cord-001734-bbeznd3r	61	4	[	[	-LRB-
cord-001734-bbeznd3r	61	5	13	13	CD
cord-001734-bbeznd3r	61	6	C]-glucose	C]-glucose	NNPS
cord-001734-bbeznd3r	61	7	for	for	IN
cord-001734-bbeznd3r	61	8	15	15	CD
cord-001734-bbeznd3r	61	9	N-/	N-/	NNP
cord-001734-bbeznd3r	61	10	13	13	CD
cord-001734-bbeznd3r	61	11	C	c	NN
cord-001734-bbeznd3r	61	12	-	-	HYPH
cord-001734-bbeznd3r	61	13	double	double	JJ
cord-001734-bbeznd3r	61	14	labelling	labelling	NN
cord-001734-bbeznd3r	61	15	as	as	IN
cord-001734-bbeznd3r	61	16	previously	previously	RB
cord-001734-bbeznd3r	61	17	described	describe	VBN
cord-001734-bbeznd3r	61	18	[	[	-LRB-
cord-001734-bbeznd3r	61	19	22	22	CD
cord-001734-bbeznd3r	61	20	]	]	-RRB-
cord-001734-bbeznd3r	61	21	.	.	.
cord-001734-bbeznd3r	62	1	The	the	DT
cord-001734-bbeznd3r	62	2	purity	purity	NN
cord-001734-bbeznd3r	62	3	of	of	IN
cord-001734-bbeznd3r	62	4	the	the	DT
cord-001734-bbeznd3r	62	5	recombinant	recombinant	JJ
cord-001734-bbeznd3r	62	6	proteins	protein	NNS
cord-001734-bbeznd3r	62	7	was	be	VBD
cord-001734-bbeznd3r	62	8	checked	check	VBN
cord-001734-bbeznd3r	62	9	by	by	IN
cord-001734-bbeznd3r	62	10	SDS	SDS	NNP
cord-001734-bbeznd3r	62	11	-	-	HYPH
cord-001734-bbeznd3r	62	12	PAGE	PAGE	NNP
cord-001734-bbeznd3r	62	13	gels	gel	NNS
cord-001734-bbeznd3r	62	14	and	and	CC
cord-001734-bbeznd3r	62	15	their	-PRON-	PRP$
cord-001734-bbeznd3r	62	16	molecular	molecular	JJ
cord-001734-bbeznd3r	62	17	weights	weight	NNS
cord-001734-bbeznd3r	62	18	were	be	VBD
cord-001734-bbeznd3r	62	19	verified	verify	VBN
cord-001734-bbeznd3r	62	20	by	by	IN
cord-001734-bbeznd3r	62	21	ESI	ESI	NNP
cord-001734-bbeznd3r	62	22	-	-	HYPH
cord-001734-bbeznd3r	62	23	MS	MS	NNP
cord-001734-bbeznd3r	62	24	and	and	CC
cord-001734-bbeznd3r	62	25	Voyager	Voyager	NNP
cord-001734-bbeznd3r	62	26	STR	STR	NNP
cord-001734-bbeznd3r	62	27	matrix	matrix	NN
cord-001734-bbeznd3r	62	28	-	-	HYPH
cord-001734-bbeznd3r	62	29	assisted	assist	VBN
cord-001734-bbeznd3r	62	30	laser	laser	NN
cord-001734-bbeznd3r	62	31	desorption	desorption	NN
cord-001734-bbeznd3r	62	32	ionization	ionization	NN
cord-001734-bbeznd3r	62	33	time	time	NN
cord-001734-bbeznd3r	62	34	-	-	HYPH
cord-001734-bbeznd3r	62	35	of	of	IN
cord-001734-bbeznd3r	62	36	-	-	HYPH
cord-001734-bbeznd3r	62	37	flight	flight	NN
cord-001734-bbeznd3r	62	38	-	-	HYPH
cord-001734-bbeznd3r	62	39	mass	mass	NN
cord-001734-bbeznd3r	62	40	spectrometer	spectrometer	NN
cord-001734-bbeznd3r	62	41	(	(	-LRB-
cord-001734-bbeznd3r	62	42	Applied	Applied	NNP
cord-001734-bbeznd3r	62	43	Biosystems	Biosystems	NNP
cord-001734-bbeznd3r	62	44	)	)	-RRB-
cord-001734-bbeznd3r	62	45	.	.	.
cord-001734-bbeznd3r	63	1	The	the	DT
cord-001734-bbeznd3r	63	2	concentration	concentration	NN
cord-001734-bbeznd3r	63	3	of	of	IN
cord-001734-bbeznd3r	63	4	protein	protein	NN
cord-001734-bbeznd3r	63	5	samples	sample	NNS
cord-001734-bbeznd3r	63	6	was	be	VBD
cord-001734-bbeznd3r	63	7	determined	determine	VBN
cord-001734-bbeznd3r	63	8	by	by	IN
cord-001734-bbeznd3r	63	9	the	the	DT
cord-001734-bbeznd3r	63	10	UV	uv	NN
cord-001734-bbeznd3r	63	11	spectroscopic	spectroscopic	JJ
cord-001734-bbeznd3r	63	12	method	method	NN
cord-001734-bbeznd3r	63	13	in	in	IN
cord-001734-bbeznd3r	63	14	the	the	DT
cord-001734-bbeznd3r	63	15	presence	presence	NN
cord-001734-bbeznd3r	63	16	of	of	IN
cord-001734-bbeznd3r	63	17	8	8	CD
cord-001734-bbeznd3r	63	18	M	m	NN
cord-001734-bbeznd3r	63	19	urea	urea	NN
cord-001734-bbeznd3r	63	20	[	[	-LRB-
cord-001734-bbeznd3r	63	21	23	23	CD
cord-001734-bbeznd3r	63	22	]	]	-RRB-
cord-001734-bbeznd3r	63	23	.	.	.
cord-001734-bbeznd3r	64	1	was	be	VBD
cord-001734-bbeznd3r	64	2	measured	measure	VBN
cord-001734-bbeznd3r	64	3	in	in	IN
cord-001734-bbeznd3r	64	4	the	the	DT
cord-001734-bbeznd3r	64	5	assay	assay	NN
cord-001734-bbeznd3r	64	6	buffer	buffer	NN
cord-001734-bbeznd3r	64	7	containing	contain	VBG
cord-001734-bbeznd3r	64	8	50	50	CD
cord-001734-bbeznd3r	64	9	mM	mm	CD
cord-001734-bbeznd3r	64	10	Tris	Tris	NNP
cord-001734-bbeznd3r	64	11	-	-	HYPH
cord-001734-bbeznd3r	64	12	HCl	HCl	NNP
cord-001734-bbeznd3r	64	13	(	(	-LRB-
cord-001734-bbeznd3r	64	14	pH	pH	NNP
cord-001734-bbeznd3r	64	15	7.5	7.5	CD
cord-001734-bbeznd3r	64	16	)	)	-RRB-
cord-001734-bbeznd3r	64	17	,	,	,
cord-001734-bbeznd3r	64	18	0.001	0.001	CD
cord-001734-bbeznd3r	64	19	%	%	NN
cord-001734-bbeznd3r	64	20	Triton	Triton	NNP
cord-001734-bbeznd3r	64	21	X-100	x-100	NN
cord-001734-bbeznd3r	64	22	,	,	,
cord-001734-bbeznd3r	64	23	0.5	0.5	CD
cord-001734-bbeznd3r	64	24	mM	mm	CD
cord-001734-bbeznd3r	64	25	EGTA	EGTA	NNP
cord-001734-bbeznd3r	64	26	,	,	,
cord-001734-bbeznd3r	64	27	or	or	CC
cord-001734-bbeznd3r	64	28	100	100	CD
cord-001734-bbeznd3r	64	29	mM	mm	CD
cord-001734-bbeznd3r	64	30	sodium	sodium	NN
cord-001734-bbeznd3r	64	31	acetate	acetate	NN
cord-001734-bbeznd3r	64	32	(	(	-LRB-
cord-001734-bbeznd3r	64	33	pH	pH	NNP
cord-001734-bbeznd3r	64	34	4.0	4.0	CD
cord-001734-bbeznd3r	64	35	)	)	-RRB-
cord-001734-bbeznd3r	64	36	,	,	,
cord-001734-bbeznd3r	64	37	0.001	0.001	CD
cord-001734-bbeznd3r	64	38	%	%	NN
cord-001734-bbeznd3r	64	39	Triton	Triton	NNP
cord-001734-bbeznd3r	64	40	X-100	x-100	NN
cord-001734-bbeznd3r	64	41	,	,	,
cord-001734-bbeznd3r	64	42	0.5	0.5	CD
cord-001734-bbeznd3r	64	43	mM	mm	CD
cord-001734-bbeznd3r	64	44	EGTA	EGTA	NNP
cord-001734-bbeznd3r	64	45	.	.	.
cord-001734-bbeznd3r	65	1	Briefly	briefly	RB
cord-001734-bbeznd3r	65	2	,	,	,
cord-001734-bbeznd3r	65	3	in	in	IN
cord-001734-bbeznd3r	65	4	the	the	DT
cord-001734-bbeznd3r	65	5	100	100	CD
cord-001734-bbeznd3r	65	6	μl	μl	IN
cord-001734-bbeznd3r	65	7	reaction	reaction	NN
cord-001734-bbeznd3r	65	8	mixtures	mixture	NNS
cord-001734-bbeznd3r	65	9	containing	contain	VBG
cord-001734-bbeznd3r	65	10	0.3	0.3	CD
cord-001734-bbeznd3r	65	11	μM	μm	CD
cord-001734-bbeznd3r	65	12	protease	protease	NN
cord-001734-bbeznd3r	65	13	,	,	,
cord-001734-bbeznd3r	65	14	20	20	CD
cord-001734-bbeznd3r	65	15	μM	μm	CD
cord-001734-bbeznd3r	65	16	protease	protease	NN
cord-001734-bbeznd3r	65	17	specific	specific	JJ
cord-001734-bbeznd3r	65	18	fluorophore	fluorophore	RB
cord-001734-bbeznd3r	65	19	-	-	HYPH
cord-001734-bbeznd3r	65	20	tagged	tag	VBN
cord-001734-bbeznd3r	65	21	substrate	substrate	NN
cord-001734-bbeznd3r	65	22	benzoyl	benzoyl	NN
cord-001734-bbeznd3r	65	23	-	-	HYPH
cord-001734-bbeznd3r	65	24	Nle	Nle	NNP
cord-001734-bbeznd3r	65	25	-	-	HYPH
cord-001734-bbeznd3r	65	26	Lys	Lys	NNP
cord-001734-bbeznd3r	65	27	-	-	HYPH
cord-001734-bbeznd3r	65	28	Arg	arg	NN
cord-001734-bbeznd3r	65	29	-	-	HYPH
cord-001734-bbeznd3r	65	30	Arg	arg	NN
cord-001734-bbeznd3r	65	31	-	-	HYPH
cord-001734-bbeznd3r	65	32	aminomethylcoumarin	aminomethylcoumarin	NNP
cord-001734-bbeznd3r	66	1	(	(	-LRB-
cord-001734-bbeznd3r	66	2	Bz	bz	NN
cord-001734-bbeznd3r	66	3	-	-	HYPH
cord-001734-bbeznd3r	66	4	nKRR	nKRR	NNP
cord-001734-bbeznd3r	66	5	-	-	HYPH
cord-001734-bbeznd3r	66	6	AMC	AMC	NNP
cord-001734-bbeznd3r	66	7	)	)	-RRB-
cord-001734-bbeznd3r	66	8	was	be	VBD
cord-001734-bbeznd3r	66	9	added	add	VBN
cord-001734-bbeznd3r	66	10	and	and	CC
cord-001734-bbeznd3r	66	11	reaction	reaction	NN
cord-001734-bbeznd3r	66	12	mixtures	mixture	NNS
cord-001734-bbeznd3r	66	13	were	be	VBD
cord-001734-bbeznd3r	66	14	incubated	incubate	VBN
cord-001734-bbeznd3r	66	15	at	at	IN
cord-001734-bbeznd3r	66	16	37	37	CD
cord-001734-bbeznd3r	66	17	°	°	NN
cord-001734-bbeznd3r	66	18	C	c	NN
cord-001734-bbeznd3r	66	19	,	,	,
cord-001734-bbeznd3r	66	20	and	and	CC
cord-001734-bbeznd3r	66	21	the	the	DT
cord-001734-bbeznd3r	66	22	liberated	liberated	JJ
cord-001734-bbeznd3r	66	23	coumarin	coumarin	NN
cord-001734-bbeznd3r	66	24	fluorophore	fluorophore	NN
cord-001734-bbeznd3r	66	25	was	be	VBD
cord-001734-bbeznd3r	66	26	continuously	continuously	RB
cord-001734-bbeznd3r	66	27	monitored	monitor	VBN
cord-001734-bbeznd3r	66	28	at	at	IN
cord-001734-bbeznd3r	66	29	λ	λ	NNP
cord-001734-bbeznd3r	66	30	ex	ex	NNP
cord-001734-bbeznd3r	66	31	of	of	IN
cord-001734-bbeznd3r	66	32	380	380	CD
cord-001734-bbeznd3r	66	33	nm	nm	NN
cord-001734-bbeznd3r	66	34	and	and	CC
cord-001734-bbeznd3r	66	35	λ	λ	NNP
cord-001734-bbeznd3r	66	36	em	-PRON-	NN
cord-001734-bbeznd3r	66	37	of	of	IN
cord-001734-bbeznd3r	66	38	450	450	CD
cord-001734-bbeznd3r	66	39	nm	nm	NN
cord-001734-bbeznd3r	66	40	on	on	IN
cord-001734-bbeznd3r	66	41	Infinite	Infinite	NNP
cord-001734-bbeznd3r	66	42	M200	M200	NNP
cord-001734-bbeznd3r	66	43	PRO	pro	JJ
cord-001734-bbeznd3r	66	44	Tecan	Tecan	NNP
cord-001734-bbeznd3r	66	45	microplate	microplate	NN
cord-001734-bbeznd3r	66	46	reader	reader	NN
cord-001734-bbeznd3r	66	47	.	.	.
cord-001734-bbeznd3r	67	1	For	for	IN
cord-001734-bbeznd3r	67	2	steady	steady	JJ
cord-001734-bbeznd3r	67	3	state	state	NN
cord-001734-bbeznd3r	67	4	kinetics	kinetic	NNS
cord-001734-bbeznd3r	67	5	,	,	,
cord-001734-bbeznd3r	67	6	0.3	0.3	CD
cord-001734-bbeznd3r	67	7	μM	μm	CD
cord-001734-bbeznd3r	67	8	refolded	refolde	VBN
cord-001734-bbeznd3r	67	9	NS3-NS2B	NS3-NS2B	NNP
cord-001734-bbeznd3r	67	10	protease	protease	NN
cord-001734-bbeznd3r	67	11	was	be	VBD
cord-001734-bbeznd3r	67	12	incubated	incubate	VBN
cord-001734-bbeznd3r	67	13	with	with	IN
cord-001734-bbeznd3r	67	14	various	various	JJ
cord-001734-bbeznd3r	67	15	concentrations	concentration	NNS
cord-001734-bbeznd3r	67	16	of	of	IN
cord-001734-bbeznd3r	67	17	Bz	bz	JJ
cord-001734-bbeznd3r	67	18	-	-	HYPH
cord-001734-bbeznd3r	67	19	nKRR	nkrr	JJ
cord-001734-bbeznd3r	67	20	-	-	HYPH
cord-001734-bbeznd3r	67	21	AMC	AMC	NNP
cord-001734-bbeznd3r	67	22	substrate	substrate	NN
cord-001734-bbeznd3r	67	23	in	in	IN
cord-001734-bbeznd3r	67	24	assay	assay	NN
cord-001734-bbeznd3r	67	25	buffer	buffer	NN
cord-001734-bbeznd3r	67	26	containing	contain	VBG
cord-001734-bbeznd3r	67	27	50	50	CD
cord-001734-bbeznd3r	67	28	mM	mm	CD
cord-001734-bbeznd3r	67	29	Tris	Tris	NNP
cord-001734-bbeznd3r	67	30	-	-	HYPH
cord-001734-bbeznd3r	67	31	HCl	HCl	NNP
cord-001734-bbeznd3r	67	32	(	(	-LRB-
cord-001734-bbeznd3r	67	33	pH	pH	NNP
cord-001734-bbeznd3r	67	34	7.5	7.5	CD
cord-001734-bbeznd3r	67	35	)	)	-RRB-
cord-001734-bbeznd3r	67	36	,	,	,
cord-001734-bbeznd3r	67	37	0.001	0.001	CD
cord-001734-bbeznd3r	67	38	%	%	NN
cord-001734-bbeznd3r	67	39	Triton	Triton	NNP
cord-001734-bbeznd3r	67	40	X-100	x-100	NN
cord-001734-bbeznd3r	67	41	,	,	,
cord-001734-bbeznd3r	67	42	0.5	0.5	CD
cord-001734-bbeznd3r	67	43	mM	mm	CD
cord-001734-bbeznd3r	67	44	EGTA	EGTA	NNP
cord-001734-bbeznd3r	67	45	at	at	IN
cord-001734-bbeznd3r	67	46	37	37	CD
cord-001734-bbeznd3r	67	47	°	°	NN
cord-001734-bbeznd3r	67	48	C	c	NN
cord-001734-bbeznd3r	67	49	.	.	.
cord-001734-bbeznd3r	68	1	Progression	progression	NN
cord-001734-bbeznd3r	68	2	of	of	IN
cord-001734-bbeznd3r	68	3	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	68	4	reaction	reaction	NN
cord-001734-bbeznd3r	68	5	was	be	VBD
cord-001734-bbeznd3r	68	6	monitored	monitor	VBN
cord-001734-bbeznd3r	68	7	as	as	IN
cord-001734-bbeznd3r	68	8	an	an	DT
cord-001734-bbeznd3r	68	9	increase	increase	NN
cord-001734-bbeznd3r	68	10	in	in	IN
cord-001734-bbeznd3r	68	11	fluorescence	fluorescence	NN
cord-001734-bbeznd3r	68	12	at	at	IN
cord-001734-bbeznd3r	68	13	λ	λ	NNP
cord-001734-bbeznd3r	68	14	ex	ex	NN
cord-001734-bbeznd3r	68	15	of	of	IN
cord-001734-bbeznd3r	68	16	380	380	CD
cord-001734-bbeznd3r	68	17	nm	nm	NN
cord-001734-bbeznd3r	68	18	and	and	CC
cord-001734-bbeznd3r	68	19	λ	λ	NNP
cord-001734-bbeznd3r	68	20	em	-PRON-	NN
cord-001734-bbeznd3r	68	21	of	of	IN
cord-001734-bbeznd3r	68	22	450	450	CD
cord-001734-bbeznd3r	68	23	nm	nm	NN
cord-001734-bbeznd3r	68	24	.	.	.
cord-001734-bbeznd3r	69	1	Initial	initial	JJ
cord-001734-bbeznd3r	69	2	fluorescence	fluorescence	NN
cord-001734-bbeznd3r	69	3	velocities	velocity	NNS
cord-001734-bbeznd3r	69	4	(	(	-LRB-
cord-001734-bbeznd3r	69	5	relative	relative	JJ
cord-001734-bbeznd3r	69	6	fluorescence	fluorescence	NN
cord-001734-bbeznd3r	69	7	units	unit	NNS
cord-001734-bbeznd3r	69	8	/	/	SYM
cord-001734-bbeznd3r	69	9	sec	sec	NNP
cord-001734-bbeznd3r	69	10	)	)	-RRB-
cord-001734-bbeznd3r	69	11	were	be	VBD
cord-001734-bbeznd3r	69	12	calculated	calculate	VBN
cord-001734-bbeznd3r	69	13	and	and	CC
cord-001734-bbeznd3r	69	14	curves	curve	NNS
cord-001734-bbeznd3r	69	15	were	be	VBD
cord-001734-bbeznd3r	69	16	fitted	fit	VBN
cord-001734-bbeznd3r	69	17	to	to	IN
cord-001734-bbeznd3r	69	18	the	the	DT
cord-001734-bbeznd3r	69	19	Michaelis	Michaelis	NNP
cord-001734-bbeznd3r	69	20	-	-	HYPH
cord-001734-bbeznd3r	69	21	Menten	Menten	NNP
cord-001734-bbeznd3r	69	22	equation	equation	NN
cord-001734-bbeznd3r	69	23	by	by	IN
cord-001734-bbeznd3r	69	24	nonlinear	nonlinear	JJ
cord-001734-bbeznd3r	69	25	regression	regression	NN
cord-001734-bbeznd3r	69	26	using	use	VBG
cord-001734-bbeznd3r	69	27	Graph	Graph	NNP
cord-001734-bbeznd3r	69	28	-	-	HYPH
cord-001734-bbeznd3r	69	29	Pad	Pad	NNP
cord-001734-bbeznd3r	69	30	Prism	Prism	NNP
cord-001734-bbeznd3r	69	31	.	.	.
cord-001734-bbeznd3r	70	1	Steady	steady	JJ
cord-001734-bbeznd3r	70	2	-	-	HYPH
cord-001734-bbeznd3r	70	3	state	state	NN
cord-001734-bbeznd3r	70	4	kinetic	kinetic	JJ
cord-001734-bbeznd3r	70	5	constants	constant	NNS
cord-001734-bbeznd3r	70	6	were	be	VBD
cord-001734-bbeznd3r	70	7	determined	determine	VBN
cord-001734-bbeznd3r	70	8	from	from	IN
cord-001734-bbeznd3r	70	9	triplicate	triplicate	JJ
cord-001734-bbeznd3r	70	10	measurements	measurement	NNS
cord-001734-bbeznd3r	70	11	and	and	CC
cord-001734-bbeznd3r	70	12	reported	report	VBD
cord-001734-bbeznd3r	70	13	as	as	IN
cord-001734-bbeznd3r	70	14	mean	mean	JJ
cord-001734-bbeznd3r	70	15	Standard	Standard	NNP
cord-001734-bbeznd3r	70	16	Error	Error	NNP
cord-001734-bbeznd3r	70	17	.	.	.
cord-001734-bbeznd3r	71	1	As	as	IN
cord-001734-bbeznd3r	71	2	the	the	DT
cord-001734-bbeznd3r	71	3	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	71	4	contains	contain	VBZ
cord-001734-bbeznd3r	71	5	no	no	DT
cord-001734-bbeznd3r	71	6	free	free	JJ
cord-001734-bbeznd3r	71	7	Cys	Cys	NNP
cord-001734-bbeznd3r	71	8	residue	residue	NN
cord-001734-bbeznd3r	71	9	,	,	,
cord-001734-bbeznd3r	71	10	three	three	CD
cord-001734-bbeznd3r	71	11	single	single	JJ
cord-001734-bbeznd3r	71	12	-	-	HYPH
cord-001734-bbeznd3r	71	13	Cys	Cys	NNP
cord-001734-bbeznd3r	71	14	mutants	mutant	NNS
cord-001734-bbeznd3r	71	15	were	be	VBD
cord-001734-bbeznd3r	71	16	prepared	prepare	VBN
cord-001734-bbeznd3r	71	17	:	:	:
cord-001734-bbeznd3r	71	18	Q27C	Q27C	NNP
cord-001734-bbeznd3r	71	19	,	,	,
cord-001734-bbeznd3r	71	20	E86C	e86c	NN
cord-001734-bbeznd3r	71	21	,	,	,
cord-001734-bbeznd3r	71	22	S158C	S158C	NNP
cord-001734-bbeznd3r	71	23	by	by	IN
cord-001734-bbeznd3r	71	24	use	use	NN
cord-001734-bbeznd3r	71	25	of	of	IN
cord-001734-bbeznd3r	71	26	the	the	DT
cord-001734-bbeznd3r	71	27	QuikChange	QuikChange	NNP
cord-001734-bbeznd3r	71	28	Site	Site	NNP
cord-001734-bbeznd3r	71	29	-	-	:
cord-001734-bbeznd3r	71	30	Directed	Directed	NNP
cord-001734-bbeznd3r	71	31	Mutagenesis	Mutagenesis	NNP
cord-001734-bbeznd3r	71	32	Kit	kit	NN
cord-001734-bbeznd3r	71	33	(	(	-LRB-
cord-001734-bbeznd3r	71	34	Stratagene	Stratagene	NNP
cord-001734-bbeznd3r	71	35	,	,	,
cord-001734-bbeznd3r	71	36	La	La	NNP
cord-001734-bbeznd3r	71	37	Jolla	Jolla	NNP
cord-001734-bbeznd3r	71	38	,	,	,
cord-001734-bbeznd3r	71	39	CA	CA	NNP
cord-001734-bbeznd3r	71	40	,	,	,
cord-001734-bbeznd3r	71	41	USA	USA	NNP
cord-001734-bbeznd3r	71	42	)	)	-RRB-
cord-001734-bbeznd3r	71	43	as	as	IN
cord-001734-bbeznd3r	71	44	previously	previously	RB
cord-001734-bbeznd3r	71	45	described	describe	VBN
cord-001734-bbeznd3r	71	46	[	[	-LRB-
cord-001734-bbeznd3r	71	47	18	18	CD
cord-001734-bbeznd3r	71	48	]	]	-RRB-
cord-001734-bbeznd3r	71	49	.	.	.
cord-001734-bbeznd3r	72	1	The	the	DT
cord-001734-bbeznd3r	72	2	mutated	mutated	JJ
cord-001734-bbeznd3r	72	3	plasmids	plasmid	NNS
cord-001734-bbeznd3r	72	4	were	be	VBD
cord-001734-bbeznd3r	72	5	confirmed	confirm	VBN
cord-001734-bbeznd3r	72	6	by	by	IN
cord-001734-bbeznd3r	72	7	DNA	dna	NN
cord-001734-bbeznd3r	72	8	sequencing	sequencing	NN
cord-001734-bbeznd3r	72	9	and	and	CC
cord-001734-bbeznd3r	72	10	their	-PRON-	PRP$
cord-001734-bbeznd3r	72	11	recombinant	recombinant	JJ
cord-001734-bbeznd3r	72	12	proteins	protein	NNS
cord-001734-bbeznd3r	72	13	were	be	VBD
cord-001734-bbeznd3r	72	14	subsequently	subsequently	RB
cord-001734-bbeznd3r	72	15	expressed	express	VBN
cord-001734-bbeznd3r	72	16	and	and	CC
cord-001734-bbeznd3r	72	17	purified	purify	VBN
cord-001734-bbeznd3r	72	18	by	by	IN
cord-001734-bbeznd3r	72	19	the	the	DT
cord-001734-bbeznd3r	72	20	same	same	JJ
cord-001734-bbeznd3r	72	21	procedures	procedure	NNS
cord-001734-bbeznd3r	72	22	described	describe	VBN
cord-001734-bbeznd3r	72	23	above	above	RB
cord-001734-bbeznd3r	72	24	.	.	.
cord-001734-bbeznd3r	73	1	1	1	LS
cord-001734-bbeznd3r	74	1	H-15	H-15	NNP
cord-001734-bbeznd3r	74	2	N	n	CD
cord-001734-bbeznd3r	74	3	heteronuclear	heteronuclear	NN
cord-001734-bbeznd3r	74	4	single	single	JJ
cord-001734-bbeznd3r	74	5	quantum	quantum	NN
cord-001734-bbeznd3r	74	6	coherence	coherence	NN
cord-001734-bbeznd3r	74	7	spectroscopy	spectroscopy	NN
cord-001734-bbeznd3r	74	8	(	(	-LRB-
cord-001734-bbeznd3r	74	9	HSQC	HSQC	NNP
cord-001734-bbeznd3r	74	10	)	)	-RRB-
cord-001734-bbeznd3r	74	11	experiments	experiment	NNS
cord-001734-bbeznd3r	74	12	were	be	VBD
cord-001734-bbeznd3r	74	13	performed	perform	VBN
cord-001734-bbeznd3r	74	14	on	on	IN
cord-001734-bbeznd3r	74	15	each	each	DT
cord-001734-bbeznd3r	74	16	mutant	mutant	JJ
cord-001734-bbeznd3r	74	17	to	to	TO
cord-001734-bbeznd3r	74	18	validate	validate	VB
cord-001734-bbeznd3r	74	19	that	that	IN
cord-001734-bbeznd3r	74	20	these	these	DT
cord-001734-bbeznd3r	74	21	mutations	mutation	NNS
cord-001734-bbeznd3r	74	22	did	do	VBD
cord-001734-bbeznd3r	74	23	not	not	RB
cord-001734-bbeznd3r	74	24	significantly	significantly	RB
cord-001734-bbeznd3r	74	25	perturb	perturb	VB
cord-001734-bbeznd3r	74	26	the	the	DT
cord-001734-bbeznd3r	74	27	conformation	conformation	NN
cord-001734-bbeznd3r	74	28	of	of	IN
cord-001734-bbeznd3r	74	29	the	the	DT
cord-001734-bbeznd3r	74	30	native	native	JJ
cord-001734-bbeznd3r	74	31	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	74	32	sequence	sequence	NN
cord-001734-bbeznd3r	74	33	.	.	.
cord-001734-bbeznd3r	75	1	The	the	DT
cord-001734-bbeznd3r	75	2	recombinant	recombinant	JJ
cord-001734-bbeznd3r	75	3	proteins	protein	NNS
cord-001734-bbeznd3r	75	4	of	of	IN
cord-001734-bbeznd3r	75	5	three	three	CD
cord-001734-bbeznd3r	75	6	single	single	JJ
cord-001734-bbeznd3r	75	7	-	-	HYPH
cord-001734-bbeznd3r	75	8	cysteine	cysteine	NN
cord-001734-bbeznd3r	75	9	mutants	mutant	NNS
cord-001734-bbeznd3r	75	10	were	be	VBD
cord-001734-bbeznd3r	75	11	Cys	Cys	NNP
cord-001734-bbeznd3r	75	12	-	-	HYPH
cord-001734-bbeznd3r	75	13	modified	modify	VBN
cord-001734-bbeznd3r	75	14	following	follow	VBG
cord-001734-bbeznd3r	75	15	the	the	DT
cord-001734-bbeznd3r	75	16	previous	previous	JJ
cord-001734-bbeznd3r	75	17	procedure	procedure	NN
cord-001734-bbeznd3r	75	18	[	[	-LRB-
cord-001734-bbeznd3r	75	19	18	18	CD
cord-001734-bbeznd3r	75	20	]	]	-RRB-
cord-001734-bbeznd3r	75	21	,	,	,
cord-001734-bbeznd3r	75	22	by	by	IN
cord-001734-bbeznd3r	75	23	the	the	DT
cord-001734-bbeznd3r	75	24	thiol	thiol	NN
cord-001734-bbeznd3r	75	25	-	-	HYPH
cord-001734-bbeznd3r	75	26	reactive	reactive	JJ
cord-001734-bbeznd3r	75	27	nitroxide	nitroxide	NN
cord-001734-bbeznd3r	75	28	free	free	JJ
cord-001734-bbeznd3r	75	29	radical	radical	JJ
cord-001734-bbeznd3r	75	30	probe	probe	NN
cord-001734-bbeznd3r	75	31	,	,	,
cord-001734-bbeznd3r	75	32	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	75	33	(	(	-LRB-
cord-001734-bbeznd3r	75	34	1-oxyl-2,2,5,5-tetramethyl	1-oxyl-2,2,5,5-tetramethyl	NNP
cord-001734-bbeznd3r	75	35	-	-	:
cord-001734-bbeznd3r	75	36	Δ3-pyrroline-3-methyl	Δ3-pyrroline-3-methyl	NNP
cord-001734-bbeznd3r	75	37	)	)	-RRB-
cord-001734-bbeznd3r	75	38	methanethiosulfonate	methanethiosulfonate	NNP
cord-001734-bbeznd3r	75	39	(	(	-LRB-
cord-001734-bbeznd3r	75	40	Toronto	Toronto	NNP
cord-001734-bbeznd3r	75	41	Research	Research	NNP
cord-001734-bbeznd3r	75	42	Chemicals	Chemicals	NNP
cord-001734-bbeznd3r	75	43	Inc.	Inc.	NNP
cord-001734-bbeznd3r	75	44	)	)	-RRB-
cord-001734-bbeznd3r	75	45	.	.	.
cord-001734-bbeznd3r	76	1	Briefly	briefly	RB
cord-001734-bbeznd3r	76	2	,	,	,
cord-001734-bbeznd3r	76	3	the	the	DT
cord-001734-bbeznd3r	76	4	HPLC	HPLC	NNP
cord-001734-bbeznd3r	76	5	-	-	HYPH
cord-001734-bbeznd3r	76	6	purified	purify	VBN
cord-001734-bbeznd3r	76	7	recombinant	recombinant	JJ
cord-001734-bbeznd3r	76	8	protein	protein	NN
cord-001734-bbeznd3r	76	9	of	of	IN
cord-001734-bbeznd3r	76	10	the	the	DT
cord-001734-bbeznd3r	76	11	each	each	DT
cord-001734-bbeznd3r	76	12	mutant	mutant	NN
cord-001734-bbeznd3r	76	13	was	be	VBD
cord-001734-bbeznd3r	76	14	dissolved	dissolve	VBN
cord-001734-bbeznd3r	76	15	in	in	IN
cord-001734-bbeznd3r	76	16	the	the	DT
cord-001734-bbeznd3r	76	17	buffer	buffer	NN
cord-001734-bbeznd3r	76	18	containing	contain	VBG
cord-001734-bbeznd3r	76	19	8	8	CD
cord-001734-bbeznd3r	76	20	M	M	NNP
cord-001734-bbeznd3r	76	21	urea	urea	NN
cord-001734-bbeznd3r	76	22	,	,	,
cord-001734-bbeznd3r	76	23	20	20	CD
cord-001734-bbeznd3r	76	24	mM	mm	NN
cord-001734-bbeznd3r	76	25	phosphate	phosphate	NN
cord-001734-bbeznd3r	76	26	(	(	-LRB-
cord-001734-bbeznd3r	76	27	pH	pH	NNP
cord-001734-bbeznd3r	76	28	8.0	8.0	CD
cord-001734-bbeznd3r	76	29	)	)	-RRB-
cord-001734-bbeznd3r	76	30	,	,	,
cord-001734-bbeznd3r	76	31	which	which	WDT
cord-001734-bbeznd3r	76	32	was	be	VBD
cord-001734-bbeznd3r	76	33	pre	pre	JJ
cord-001734-bbeznd3r	76	34	-	-	JJ
cord-001734-bbeznd3r	76	35	degassed	degas	VBN
cord-001734-bbeznd3r	76	36	with	with	IN
cord-001734-bbeznd3r	76	37	nitrogen	nitrogen	NN
cord-001734-bbeznd3r	76	38	gas	gas	NN
cord-001734-bbeznd3r	76	39	for	for	IN
cord-001734-bbeznd3r	76	40	20	20	CD
cord-001734-bbeznd3r	76	41	minutes	minute	NNS
cord-001734-bbeznd3r	76	42	.	.	.
cord-001734-bbeznd3r	77	1	Subsequently	subsequently	RB
cord-001734-bbeznd3r	77	2	,	,	,
cord-001734-bbeznd3r	77	3	the	the	DT
cord-001734-bbeznd3r	77	4	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	77	5	reagent	reagent	NN
cord-001734-bbeznd3r	77	6	was	be	VBD
cord-001734-bbeznd3r	77	7	added	add	VBN
cord-001734-bbeznd3r	77	8	from	from	IN
cord-001734-bbeznd3r	77	9	3.8	3.8	CD
cord-001734-bbeznd3r	77	10	mM	mm	CD
cord-001734-bbeznd3r	77	11	stock	stock	NN
cord-001734-bbeznd3r	77	12	solution	solution	NN
cord-001734-bbeznd3r	77	13	in	in	IN
cord-001734-bbeznd3r	77	14	acetonitrile	acetonitrile	NN
cord-001734-bbeznd3r	77	15	to	to	TO
cord-001734-bbeznd3r	77	16	reach	reach	VB
cord-001734-bbeznd3r	77	17	a	a	DT
cord-001734-bbeznd3r	77	18	six	six	CD
cord-001734-bbeznd3r	77	19	-	-	HYPH
cord-001734-bbeznd3r	77	20	fold	fold	JJ
cord-001734-bbeznd3r	77	21	molar	molar	JJ
cord-001734-bbeznd3r	77	22	concentration	concentration	NN
cord-001734-bbeznd3r	77	23	of	of	IN
cord-001734-bbeznd3r	77	24	the	the	DT
cord-001734-bbeznd3r	77	25	protein	protein	NN
cord-001734-bbeznd3r	77	26	,	,	,
cord-001734-bbeznd3r	77	27	followed	follow	VBN
cord-001734-bbeznd3r	77	28	by	by	IN
cord-001734-bbeznd3r	77	29	incubation	incubation	NN
cord-001734-bbeznd3r	77	30	at	at	IN
cord-001734-bbeznd3r	77	31	room	room	NN
cord-001734-bbeznd3r	77	32	temperature	temperature	NN
cord-001734-bbeznd3r	77	33	with	with	IN
cord-001734-bbeznd3r	77	34	constant	constant	JJ
cord-001734-bbeznd3r	77	35	stirring	stirring	NN
cord-001734-bbeznd3r	77	36	for	for	IN
cord-001734-bbeznd3r	77	37	5	5	CD
cord-001734-bbeznd3r	77	38	hours	hour	NNS
cord-001734-bbeznd3r	77	39	.	.	.
cord-001734-bbeznd3r	78	1	To	to	TO
cord-001734-bbeznd3r	78	2	ensure	ensure	VB
cord-001734-bbeznd3r	78	3	a	a	DT
cord-001734-bbeznd3r	78	4	complete	complete	JJ
cord-001734-bbeznd3r	78	5	labeling	labeling	NN
cord-001734-bbeznd3r	78	6	,	,	,
cord-001734-bbeznd3r	78	7	another	another	DT
cord-001734-bbeznd3r	78	8	dose	dose	NN
cord-001734-bbeznd3r	78	9	of	of	IN
cord-001734-bbeznd3r	78	10	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	78	11	was	be	VBD
cord-001734-bbeznd3r	78	12	added	add	VBN
cord-001734-bbeznd3r	78	13	to	to	IN
cord-001734-bbeznd3r	78	14	a	a	DT
cord-001734-bbeznd3r	78	15	six	six	CD
cord-001734-bbeznd3r	78	16	-	-	HYPH
cord-001734-bbeznd3r	78	17	fold	fold	JJ
cord-001734-bbeznd3r	78	18	molar	molar	JJ
cord-001734-bbeznd3r	78	19	concentration	concentration	NN
cord-001734-bbeznd3r	78	20	of	of	IN
cord-001734-bbeznd3r	78	21	the	the	DT
cord-001734-bbeznd3r	78	22	protein	protein	NN
cord-001734-bbeznd3r	78	23	for	for	IN
cord-001734-bbeznd3r	78	24	an	an	DT
cord-001734-bbeznd3r	78	25	overnight	overnight	JJ
cord-001734-bbeznd3r	78	26	incubation	incubation	NN
cord-001734-bbeznd3r	78	27	.	.	.
cord-001734-bbeznd3r	79	1	The	the	DT
cord-001734-bbeznd3r	79	2	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	79	3	-	-	HYPH
cord-001734-bbeznd3r	79	4	labeled	label	VBN
cord-001734-bbeznd3r	79	5	protein	protein	NN
cord-001734-bbeznd3r	79	6	was	be	VBD
cord-001734-bbeznd3r	79	7	purified	purify	VBN
cord-001734-bbeznd3r	79	8	by	by	IN
cord-001734-bbeznd3r	79	9	reverse	reverse	JJ
cord-001734-bbeznd3r	79	10	-	-	HYPH
cord-001734-bbeznd3r	79	11	phase	phase	NN
cord-001734-bbeznd3r	79	12	HPLC	HPLC	NNP
cord-001734-bbeznd3r	79	13	on	on	IN
cord-001734-bbeznd3r	79	14	a	a	DT
cord-001734-bbeznd3r	79	15	C8	c8	NN
cord-001734-bbeznd3r	79	16	column	column	NN
cord-001734-bbeznd3r	79	17	and	and	CC
cord-001734-bbeznd3r	79	18	lyophilized	lyophilize	VBD
cord-001734-bbeznd3r	79	19	.	.	.
cord-001734-bbeznd3r	80	1	Based	base	VBN
cord-001734-bbeznd3r	80	2	on	on	IN
cord-001734-bbeznd3r	80	3	the	the	DT
cord-001734-bbeznd3r	80	4	verification	verification	NN
cord-001734-bbeznd3r	80	5	by	by	IN
cord-001734-bbeznd3r	80	6	the	the	DT
cord-001734-bbeznd3r	80	7	time	time	NN
cord-001734-bbeznd3r	80	8	-	-	HYPH
cord-001734-bbeznd3r	80	9	of	of	IN
cord-001734-bbeznd3r	80	10	-	-	HYPH
cord-001734-bbeznd3r	80	11	flight	flight	NN
cord-001734-bbeznd3r	80	12	-	-	HYPH
cord-001734-bbeznd3r	80	13	mass	mass	NN
cord-001734-bbeznd3r	80	14	spectrometer	spectrometer	NN
cord-001734-bbeznd3r	80	15	,	,	,
cord-001734-bbeznd3r	80	16	the	the	DT
cord-001734-bbeznd3r	80	17	purity	purity	NN
cord-001734-bbeznd3r	80	18	of	of	IN
cord-001734-bbeznd3r	80	19	the	the	DT
cord-001734-bbeznd3r	80	20	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	80	21	-	-	HYPH
cord-001734-bbeznd3r	80	22	modified	modify	VBN
cord-001734-bbeznd3r	80	23	proteins	protein	NNS
cord-001734-bbeznd3r	80	24	of	of	IN
cord-001734-bbeznd3r	80	25	all	all	DT
cord-001734-bbeznd3r	80	26	mutants	mutant	NNS
cord-001734-bbeznd3r	80	27	was	be	VBD
cord-001734-bbeznd3r	80	28	>	>	NFP
cord-001734-bbeznd3r	80	29	99	99	CD
cord-001734-bbeznd3r	80	30	%	%	NN
cord-001734-bbeznd3r	80	31	after	after	IN
cord-001734-bbeznd3r	80	32	the	the	DT
cord-001734-bbeznd3r	80	33	HPLC	HPLC	NNP
cord-001734-bbeznd3r	80	34	purification	purification	NN
cord-001734-bbeznd3r	80	35	.	.	.
cord-001734-bbeznd3r	81	1	All	all	DT
cord-001734-bbeznd3r	81	2	circular	circular	JJ
cord-001734-bbeznd3r	81	3	dichroism	dichroism	NN
cord-001734-bbeznd3r	81	4	(	(	-LRB-
cord-001734-bbeznd3r	81	5	CD	cd	NN
cord-001734-bbeznd3r	81	6	)	)	-RRB-
cord-001734-bbeznd3r	81	7	experiments	experiment	NNS
cord-001734-bbeznd3r	81	8	were	be	VBD
cord-001734-bbeznd3r	81	9	performed	perform	VBN
cord-001734-bbeznd3r	81	10	on	on	IN
cord-001734-bbeznd3r	81	11	a	a	DT
cord-001734-bbeznd3r	81	12	Jasco	Jasco	NNP
cord-001734-bbeznd3r	81	13	J-810	j-810	XX
cord-001734-bbeznd3r	82	1	spectropolarimeter	spectropolarimeter	NNP
cord-001734-bbeznd3r	82	2	equipped	equip	VBN
cord-001734-bbeznd3r	82	3	with	with	IN
cord-001734-bbeznd3r	82	4	a	a	DT
cord-001734-bbeznd3r	82	5	thermal	thermal	JJ
cord-001734-bbeznd3r	82	6	controller	controller	NN
cord-001734-bbeznd3r	82	7	using	use	VBG
cord-001734-bbeznd3r	82	8	1-mm	1-mm	CD
cord-001734-bbeznd3r	82	9	path	path	NN
cord-001734-bbeznd3r	82	10	length	length	NN
cord-001734-bbeznd3r	82	11	cuvettes	cuvette	NNS
cord-001734-bbeznd3r	82	12	.	.	.
cord-001734-bbeznd3r	83	1	Data	datum	NNS
cord-001734-bbeznd3r	83	2	from	from	IN
cord-001734-bbeznd3r	83	3	five	five	CD
cord-001734-bbeznd3r	83	4	independent	independent	JJ
cord-001734-bbeznd3r	83	5	scans	scan	NNS
cord-001734-bbeznd3r	83	6	were	be	VBD
cord-001734-bbeznd3r	83	7	added	add	VBN
cord-001734-bbeznd3r	83	8	and	and	CC
cord-001734-bbeznd3r	83	9	averaged	average	VBD
cord-001734-bbeznd3r	83	10	[	[	-LRB-
cord-001734-bbeznd3r	83	11	18	18	CD
cord-001734-bbeznd3r	83	12	]	]	-RRB-
cord-001734-bbeznd3r	83	13	.	.	.
cord-001734-bbeznd3r	84	1	The	the	DT
cord-001734-bbeznd3r	84	2	NS2B	NS2B	NNP
cord-001734-bbeznd3r	84	3	,	,	,
cord-001734-bbeznd3r	84	4	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	84	5	and	and	CC
cord-001734-bbeznd3r	84	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	84	7	-	-	HYPH
cord-001734-bbeznd3r	84	8	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	84	9	samples	sample	NNS
cord-001734-bbeznd3r	84	10	were	be	VBD
cord-001734-bbeznd3r	84	11	prepared	prepare	VBN
cord-001734-bbeznd3r	84	12	at	at	IN
cord-001734-bbeznd3r	84	13	a	a	DT
cord-001734-bbeznd3r	84	14	protein	protein	NN
cord-001734-bbeznd3r	84	15	concentration	concentration	NN
cord-001734-bbeznd3r	84	16	of	of	IN
cord-001734-bbeznd3r	84	17	20	20	CD
cord-001734-bbeznd3r	84	18	μM	μM	NNS
cord-001734-bbeznd3r	84	19	in	in	IN
cord-001734-bbeznd3r	84	20	either	either	DT
cord-001734-bbeznd3r	84	21	Milli	Milli	NNP
cord-001734-bbeznd3r	84	22	-	-	HYPH
cord-001734-bbeznd3r	84	23	Q	Q	NNP
cord-001734-bbeznd3r	84	24	water	water	NN
cord-001734-bbeznd3r	84	25	(	(	-LRB-
cord-001734-bbeznd3r	84	26	pH	pH	NNP
cord-001734-bbeznd3r	84	27	4.0	4.0	CD
cord-001734-bbeznd3r	84	28	)	)	-RRB-
cord-001734-bbeznd3r	84	29	and	and	CC
cord-001734-bbeznd3r	84	30	1	1	CD
cord-001734-bbeznd3r	84	31	mM	mm	CD
cord-001734-bbeznd3r	84	32	phosphate	phosphate	NN
cord-001734-bbeznd3r	84	33	(	(	-LRB-
cord-001734-bbeznd3r	84	34	pH	pH	NNP
cord-001734-bbeznd3r	84	35	7.5	7.5	CD
cord-001734-bbeznd3r	84	36	)	)	-RRB-
cord-001734-bbeznd3r	84	37	respectively	respectively	RB
cord-001734-bbeznd3r	84	38	.	.	.
cord-001734-bbeznd3r	85	1	Secondary	secondary	JJ
cord-001734-bbeznd3r	85	2	structure	structure	NN
cord-001734-bbeznd3r	85	3	contents	content	NNS
cord-001734-bbeznd3r	85	4	of	of	IN
cord-001734-bbeznd3r	85	5	different	different	JJ
cord-001734-bbeznd3r	85	6	samples	sample	NNS
cord-001734-bbeznd3r	85	7	were	be	VBD
cord-001734-bbeznd3r	85	8	obtained	obtain	VBN
cord-001734-bbeznd3r	85	9	by	by	IN
cord-001734-bbeznd3r	85	10	decovoluting	decovolute	VBG
cord-001734-bbeznd3r	85	11	CD	cd	NN
cord-001734-bbeznd3r	85	12	spectra	spectrum	NNS
cord-001734-bbeznd3r	85	13	with	with	IN
cord-001734-bbeznd3r	85	14	CONTINLL	CONTINLL	NNP
cord-001734-bbeznd3r	85	15	program	program	NN
cord-001734-bbeznd3r	86	1	(	(	-LRB-
cord-001734-bbeznd3r	86	2	http://lamar.colostate.edu/~sreeram/	http://lamar.colostate.edu/~sreeram/	NNP
cord-001734-bbeznd3r	86	3	CDPro	CDPro	NNP
cord-001734-bbeznd3r	86	4	/	/	SYM
cord-001734-bbeznd3r	86	5	main.html	main.html	NNP
cord-001734-bbeznd3r	86	6	)	)	-RRB-
cord-001734-bbeznd3r	86	7	.	.	.
cord-001734-bbeznd3r	87	1	All	all	DT
cord-001734-bbeznd3r	87	2	NMR	NMR	NNP
cord-001734-bbeznd3r	87	3	experiments	experiment	NNS
cord-001734-bbeznd3r	87	4	were	be	VBD
cord-001734-bbeznd3r	87	5	acquired	acquire	VBN
cord-001734-bbeznd3r	87	6	on	on	IN
cord-001734-bbeznd3r	87	7	an	an	DT
cord-001734-bbeznd3r	87	8	800	800	CD
cord-001734-bbeznd3r	87	9	MHz	MHz	NNP
cord-001734-bbeznd3r	87	10	Bruker	Bruker	NNP
cord-001734-bbeznd3r	87	11	Avance	Avance	NNP
cord-001734-bbeznd3r	87	12	spectrometer	spectrometer	NN
cord-001734-bbeznd3r	87	13	equipped	equip	VBN
cord-001734-bbeznd3r	87	14	with	with	IN
cord-001734-bbeznd3r	87	15	pulse	pulse	NN
cord-001734-bbeznd3r	87	16	field	field	NN
cord-001734-bbeznd3r	87	17	gradient	gradient	NN
cord-001734-bbeznd3r	87	18	units	unit	NNS
cord-001734-bbeznd3r	87	19	as	as	IN
cord-001734-bbeznd3r	87	20	described	describe	VBN
cord-001734-bbeznd3r	87	21	previously	previously	RB
cord-001734-bbeznd3r	87	22	[	[	-LRB-
cord-001734-bbeznd3r	87	23	18	18	CD
cord-001734-bbeznd3r	87	24	]	]	-RRB-
cord-001734-bbeznd3r	87	25	.	.	.
cord-001734-bbeznd3r	88	1	For	for	IN
cord-001734-bbeznd3r	88	2	characterizing	characterize	VBG
cord-001734-bbeznd3r	88	3	the	the	DT
cord-001734-bbeznd3r	88	4	conformation	conformation	NN
cord-001734-bbeznd3r	88	5	of	of	IN
cord-001734-bbeznd3r	88	6	the	the	DT
cord-001734-bbeznd3r	88	7	isolated	isolated	JJ
cord-001734-bbeznd3r	88	8	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	88	9	in	in	IN
cord-001734-bbeznd3r	88	10	water	water	NN
cord-001734-bbeznd3r	88	11	,	,	,
cord-001734-bbeznd3r	88	12	a	a	DT
cord-001734-bbeznd3r	88	13	pair	pair	NN
cord-001734-bbeznd3r	88	14	of	of	IN
cord-001734-bbeznd3r	88	15	triple	triple	JJ
cord-001734-bbeznd3r	88	16	-	-	HYPH
cord-001734-bbeznd3r	88	17	resonance	resonance	NN
cord-001734-bbeznd3r	88	18	experiments	experiment	NNS
cord-001734-bbeznd3r	88	19	HNCACB	HNCACB	NNP
cord-001734-bbeznd3r	88	20	,	,	,
cord-001734-bbeznd3r	88	21	CBCA	CBCA	NNP
cord-001734-bbeznd3r	88	22	(	(	-LRB-
cord-001734-bbeznd3r	88	23	CO)NH	CO)NH	NNP
cord-001734-bbeznd3r	88	24	as	as	RB
cord-001734-bbeznd3r	88	25	well	well	RB
cord-001734-bbeznd3r	88	26	as	as	IN
cord-001734-bbeznd3r	88	27	15	15	CD
cord-001734-bbeznd3r	88	28	N	n	CD
cord-001734-bbeznd3r	88	29	-	-	HYPH
cord-001734-bbeznd3r	88	30	edited	edit	VBN
cord-001734-bbeznd3r	88	31	HSQC	HSQC	NNP
cord-001734-bbeznd3r	88	32	-	-	HYPH
cord-001734-bbeznd3r	88	33	TOCSY	TOCSY	NNP
cord-001734-bbeznd3r	88	34	and	and	CC
cord-001734-bbeznd3r	88	35	HSQC	HSQC	NNP
cord-001734-bbeznd3r	88	36	-	-	HYPH
cord-001734-bbeznd3r	88	37	NOESY	NOESY	NNP
cord-001734-bbeznd3r	88	38	were	be	VBD
cord-001734-bbeznd3r	88	39	collected	collect	VBN
cord-001734-bbeznd3r	88	40	for	for	IN
cord-001734-bbeznd3r	88	41	the	the	DT
cord-001734-bbeznd3r	88	42	sequential	sequential	JJ
cord-001734-bbeznd3r	88	43	assignment	assignment	NN
cord-001734-bbeznd3r	88	44	on	on	IN
cord-001734-bbeznd3r	88	45	a	a	DT
cord-001734-bbeznd3r	88	46	15	15	CD
cord-001734-bbeznd3r	88	47	N-/	N-/	NNP
cord-001734-bbeznd3r	88	48	13	13	CD
cord-001734-bbeznd3r	88	49	C	c	NN
cord-001734-bbeznd3r	88	50	-	-	HYPH
cord-001734-bbeznd3r	88	51	double	double	NN
cord-001734-bbeznd3r	88	52	labelled	label	VBN
cord-001734-bbeznd3r	88	53	or	or	CC
cord-001734-bbeznd3r	88	54	15	15	CD
cord-001734-bbeznd3r	88	55	N	n	CD
cord-001734-bbeznd3r	88	56	-	-	HYPH
cord-001734-bbeznd3r	88	57	labelled	label	VBN
cord-001734-bbeznd3r	88	58	sample	sample	NN
cord-001734-bbeznd3r	88	59	at	at	IN
cord-001734-bbeznd3r	88	60	a	a	DT
cord-001734-bbeznd3r	88	61	protein	protein	NN
cord-001734-bbeznd3r	88	62	concentration	concentration	NN
cord-001734-bbeznd3r	88	63	of	of	IN
cord-001734-bbeznd3r	88	64	500	500	CD
cord-001734-bbeznd3r	88	65	μM	μm	CD
cord-001734-bbeznd3r	88	66	in	in	IN
cord-001734-bbeznd3r	88	67	90	90	CD
cord-001734-bbeznd3r	88	68	%	%	NN
cord-001734-bbeznd3r	88	69	H	h	NN
cord-001734-bbeznd3r	88	70	2	2	CD
cord-001734-bbeznd3r	88	71	O/10	o/10	NN
cord-001734-bbeznd3r	88	72	%	%	NN
cord-001734-bbeznd3r	88	73	D	d	NN
cord-001734-bbeznd3r	88	74	2	2	CD
cord-001734-bbeznd3r	88	75	O	o	NN
cord-001734-bbeznd3r	88	76	(	(	-LRB-
cord-001734-bbeznd3r	88	77	pH	pH	NNP
cord-001734-bbeznd3r	88	78	4.0	4.0	CD
cord-001734-bbeznd3r	88	79	)	)	-RRB-
cord-001734-bbeznd3r	88	80	.	.	.
cord-001734-bbeznd3r	89	1	For	for	IN
cord-001734-bbeznd3r	89	2	the	the	DT
cord-001734-bbeznd3r	89	3	refolded	refolde	VBN
cord-001734-bbeznd3r	89	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	89	5	-	-	HYPH
cord-001734-bbeznd3r	89	6	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	89	7	complexes	complex	NNS
cord-001734-bbeznd3r	89	8	,	,	,
cord-001734-bbeznd3r	89	9	HSQC	HSQC	NNP
cord-001734-bbeznd3r	89	10	spectra	spectrum	NNS
cord-001734-bbeznd3r	89	11	were	be	VBD
cord-001734-bbeznd3r	89	12	collected	collect	VBN
cord-001734-bbeznd3r	89	13	for	for	IN
cord-001734-bbeznd3r	89	14	15	15	CD
cord-001734-bbeznd3r	89	15	N	n	CD
cord-001734-bbeznd3r	89	16	-	-	HYPH
cord-001734-bbeznd3r	89	17	labeled	label	VBN
cord-001734-bbeznd3r	89	18	samples	sample	NNS
cord-001734-bbeznd3r	89	19	in	in	IN
cord-001734-bbeznd3r	89	20	either	either	DT
cord-001734-bbeznd3r	89	21	acetate	acetate	NN
cord-001734-bbeznd3r	89	22	buffer	buffer	NN
cord-001734-bbeznd3r	89	23	(	(	-LRB-
cord-001734-bbeznd3r	89	24	pH	pH	NNP
cord-001734-bbeznd3r	89	25	4.0	4.0	CD
cord-001734-bbeznd3r	89	26	)	)	-RRB-
cord-001734-bbeznd3r	89	27	,	,	,
cord-001734-bbeznd3r	89	28	or	or	CC
cord-001734-bbeznd3r	89	29	phosphate	phosphate	NN
cord-001734-bbeznd3r	89	30	buffer	buffer	NN
cord-001734-bbeznd3r	89	31	(	(	-LRB-
cord-001734-bbeznd3r	89	32	pH	pH	NNP
cord-001734-bbeznd3r	89	33	7.5	7.5	CD
cord-001734-bbeznd3r	89	34	)	)	-RRB-
cord-001734-bbeznd3r	89	35	in	in	IN
cord-001734-bbeznd3r	89	36	the	the	DT
cord-001734-bbeznd3r	89	37	absence	absence	NN
cord-001734-bbeznd3r	89	38	and	and	CC
cord-001734-bbeznd3r	89	39	in	in	IN
cord-001734-bbeznd3r	89	40	the	the	DT
cord-001734-bbeznd3r	89	41	presence	presence	NN
cord-001734-bbeznd3r	89	42	of	of	IN
cord-001734-bbeznd3r	89	43	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	89	44	p	p	NNP
cord-001734-bbeznd3r	89	45	-	-	:
cord-001734-bbeznd3r	89	46	Nitrophenyl	Nitrophenyl	NNP
cord-001734-bbeznd3r	89	47	-	-	HYPH
cord-001734-bbeznd3r	89	48	pguanidino	pguanidino	NN
cord-001734-bbeznd3r	89	49	benzoate	benzoate	NN
cord-001734-bbeznd3r	89	50	[	[	-LRB-
cord-001734-bbeznd3r	89	51	11	11	CD
cord-001734-bbeznd3r	89	52	]	]	-RRB-
cord-001734-bbeznd3r	89	53	.	.	.
cord-001734-bbeznd3r	90	1	For	for	IN
cord-001734-bbeznd3r	90	2	assessing	assess	VBG
cord-001734-bbeznd3r	90	3	the	the	DT
cord-001734-bbeznd3r	90	4	backbone	backbone	NN
cord-001734-bbeznd3r	90	5	dynamics	dynamic	NNS
cord-001734-bbeznd3r	90	6	on	on	IN
cord-001734-bbeznd3r	90	7	the	the	DT
cord-001734-bbeznd3r	90	8	ps	ps	NNP
cord-001734-bbeznd3r	90	9	-	-	HYPH
cord-001734-bbeznd3r	90	10	ns	ns	NNP
cord-001734-bbeznd3r	90	11	time	time	NN
cord-001734-bbeznd3r	90	12	scale	scale	NN
cord-001734-bbeznd3r	90	13	,	,	,
cord-001734-bbeznd3r	90	14	{	{	-LRB-
cord-001734-bbeznd3r	90	15	1	1	CD
cord-001734-bbeznd3r	90	16	H}-15	H}-15	NNP
cord-001734-bbeznd3r	90	17	N	n	CD
cord-001734-bbeznd3r	90	18	steady	steady	JJ
cord-001734-bbeznd3r	90	19	-	-	HYPH
cord-001734-bbeznd3r	90	20	state	state	NN
cord-001734-bbeznd3r	90	21	NOEs	no	NNS
cord-001734-bbeznd3r	90	22	were	be	VBD
cord-001734-bbeznd3r	90	23	obtained	obtain	VBN
cord-001734-bbeznd3r	90	24	by	by	IN
cord-001734-bbeznd3r	90	25	recording	record	VBG
cord-001734-bbeznd3r	90	26	spectra	spectrum	NNS
cord-001734-bbeznd3r	90	27	on	on	IN
cord-001734-bbeznd3r	90	28	the	the	DT
cord-001734-bbeznd3r	90	29	15	15	CD
cord-001734-bbeznd3r	90	30	N	n	CD
cord-001734-bbeznd3r	90	31	-	-	HYPH
cord-001734-bbeznd3r	90	32	labeled	label	VBN
cord-001734-bbeznd3r	90	33	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	90	34	domain	domain	NN
cord-001734-bbeznd3r	90	35	at	at	IN
cord-001734-bbeznd3r	90	36	500	500	CD
cord-001734-bbeznd3r	90	37	μM	μM	NNS
cord-001734-bbeznd3r	90	38	in	in	IN
cord-001734-bbeznd3r	90	39	either	either	DT
cord-001734-bbeznd3r	90	40	Milli	Milli	NNP
cord-001734-bbeznd3r	90	41	-	-	HYPH
cord-001734-bbeznd3r	90	42	Q	Q	NNP
cord-001734-bbeznd3r	90	43	water	water	NN
cord-001734-bbeznd3r	90	44	(	(	-LRB-
cord-001734-bbeznd3r	90	45	pH	pH	NNP
cord-001734-bbeznd3r	90	46	4.0	4.0	CD
cord-001734-bbeznd3r	90	47	)	)	-RRB-
cord-001734-bbeznd3r	90	48	,	,	,
cord-001734-bbeznd3r	90	49	with	with	IN
cord-001734-bbeznd3r	90	50	and	and	CC
cord-001734-bbeznd3r	90	51	without	without	IN
cord-001734-bbeznd3r	90	52	1	1	CD
cord-001734-bbeznd3r	90	53	H	h	NN
cord-001734-bbeznd3r	90	54	presaturation	presaturation	NN
cord-001734-bbeznd3r	90	55	with	with	IN
cord-001734-bbeznd3r	90	56	duration	duration	NN
cord-001734-bbeznd3r	90	57	of	of	IN
cord-001734-bbeznd3r	90	58	3	3	CD
cord-001734-bbeznd3r	90	59	s	s	NN
cord-001734-bbeznd3r	90	60	plus	plus	CC
cord-001734-bbeznd3r	90	61	a	a	DT
cord-001734-bbeznd3r	90	62	relaxation	relaxation	NN
cord-001734-bbeznd3r	90	63	delay	delay	NN
cord-001734-bbeznd3r	90	64	of	of	IN
cord-001734-bbeznd3r	90	65	6	6	CD
cord-001734-bbeznd3r	90	66	s	s	NN
cord-001734-bbeznd3r	90	67	at	at	IN
cord-001734-bbeznd3r	90	68	800	800	CD
cord-001734-bbeznd3r	90	69	MHz	MHz	NNS
cord-001734-bbeznd3r	90	70	.	.	.
cord-001734-bbeznd3r	91	1	All	all	DT
cord-001734-bbeznd3r	91	2	NMR	NMR	NNP
cord-001734-bbeznd3r	91	3	data	datum	NNS
cord-001734-bbeznd3r	91	4	were	be	VBD
cord-001734-bbeznd3r	91	5	processed	process	VBN
cord-001734-bbeznd3r	91	6	with	with	IN
cord-001734-bbeznd3r	91	7	NMRPipe	nmrpipe	NN
cord-001734-bbeznd3r	91	8	[	[	-LRB-
cord-001734-bbeznd3r	91	9	24	24	CD
cord-001734-bbeznd3r	91	10	]	]	-RRB-
cord-001734-bbeznd3r	91	11	and	and	CC
cord-001734-bbeznd3r	91	12	analysed	analyse	VBD
cord-001734-bbeznd3r	91	13	with	with	IN
cord-001734-bbeznd3r	91	14	NMRView	nmrview	JJ
cord-001734-bbeznd3r	91	15	[	[	-LRB-
cord-001734-bbeznd3r	91	16	25	25	CD
cord-001734-bbeznd3r	91	17	]	]	-RRB-
cord-001734-bbeznd3r	91	18	.	.	.
cord-001734-bbeznd3r	92	1	NH	NH	NNP
cord-001734-bbeznd3r	92	2	,	,	,
cord-001734-bbeznd3r	92	3	N	N	NNP
cord-001734-bbeznd3r	92	4	,	,	,
cord-001734-bbeznd3r	92	5	Cα	Cα	NNP
cord-001734-bbeznd3r	92	6	and	and	CC
cord-001734-bbeznd3r	92	7	Cβ	Cβ	NNP
cord-001734-bbeznd3r	92	8	chemical	chemical	NN
cord-001734-bbeznd3r	92	9	shifts	shift	NNS
cord-001734-bbeznd3r	92	10	of	of	IN
cord-001734-bbeznd3r	92	11	the	the	DT
cord-001734-bbeznd3r	92	12	isolated	isolated	JJ
cord-001734-bbeznd3r	92	13	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	92	14	in	in	IN
cord-001734-bbeznd3r	92	15	water	water	NN
cord-001734-bbeznd3r	92	16	at	at	IN
cord-001734-bbeznd3r	92	17	pH	pH	NNP
cord-001734-bbeznd3r	92	18	4.0	4.0	CD
cord-001734-bbeznd3r	92	19	were	be	VBD
cord-001734-bbeznd3r	92	20	further	further	RB
cord-001734-bbeznd3r	92	21	analyzed	analyze	VBN
cord-001734-bbeznd3r	92	22	by	by	IN
cord-001734-bbeznd3r	92	23	both	both	DT
cord-001734-bbeznd3r	92	24	Delta2D	Delta2D	NNS
cord-001734-bbeznd3r	92	25	[	[	-LRB-
cord-001734-bbeznd3r	92	26	26	26	CD
cord-001734-bbeznd3r	92	27	]	]	-RRB-
cord-001734-bbeznd3r	92	28	to	to	TO
cord-001734-bbeznd3r	92	29	derive	derive	VB
cord-001734-bbeznd3r	92	30	the	the	DT
cord-001734-bbeznd3r	92	31	secondary	secondary	JJ
cord-001734-bbeznd3r	92	32	structure	structure	NN
cord-001734-bbeznd3r	92	33	population	population	NN
cord-001734-bbeznd3r	92	34	.	.	.
cord-001734-bbeznd3r	93	1	For	for	IN
cord-001734-bbeznd3r	93	2	each	each	DT
cord-001734-bbeznd3r	93	3	spin	spin	NN
cord-001734-bbeznd3r	93	4	-	-	HYPH
cord-001734-bbeznd3r	93	5	labeled	label	VBN
cord-001734-bbeznd3r	93	6	single	single	JJ
cord-001734-bbeznd3r	93	7	-	-	HYPH
cord-001734-bbeznd3r	93	8	cysteine	cysteine	NN
cord-001734-bbeznd3r	93	9	mutant	mutant	NN
cord-001734-bbeznd3r	93	10	,	,	,
cord-001734-bbeznd3r	93	11	a	a	DT
cord-001734-bbeznd3r	93	12	pair	pair	NN
cord-001734-bbeznd3r	93	13	of	of	IN
cord-001734-bbeznd3r	93	14	2D	2d	NN
cord-001734-bbeznd3r	93	15	1	1	CD
cord-001734-bbeznd3r	93	16	H-15	H-15	NNP
cord-001734-bbeznd3r	93	17	N	N	NNP
cord-001734-bbeznd3r	93	18	HSQC	HSQC	NNP
cord-001734-bbeznd3r	93	19	spectra	spectrum	NNS
cord-001734-bbeznd3r	93	20	were	be	VBD
cord-001734-bbeznd3r	93	21	acquired	acquire	VBN
cord-001734-bbeznd3r	93	22	at	at	IN
cord-001734-bbeznd3r	93	23	a	a	DT
cord-001734-bbeznd3r	93	24	protein	protein	NN
cord-001734-bbeznd3r	93	25	concentration	concentration	NN
cord-001734-bbeznd3r	93	26	of	of	IN
cord-001734-bbeznd3r	93	27	150	150	CD
cord-001734-bbeznd3r	93	28	μM	μm	NN
cord-001734-bbeznd3r	93	29	in	in	IN
cord-001734-bbeznd3r	93	30	Milli	Milli	NNP
cord-001734-bbeznd3r	93	31	-	-	HYPH
cord-001734-bbeznd3r	93	32	Q	Q	NNP
cord-001734-bbeznd3r	93	33	water	water	NN
cord-001734-bbeznd3r	93	34	(	(	-LRB-
cord-001734-bbeznd3r	93	35	pH	pH	NNP
cord-001734-bbeznd3r	93	36	4.0	4.0	CD
cord-001734-bbeznd3r	93	37	)	)	-RRB-
cord-001734-bbeznd3r	93	38	:	:	:
cord-001734-bbeznd3r	93	39	one	one	CD
cord-001734-bbeznd3r	93	40	for	for	IN
cord-001734-bbeznd3r	93	41	the	the	DT
cord-001734-bbeznd3r	93	42	spin	spin	NN
cord-001734-bbeznd3r	93	43	-	-	HYPH
cord-001734-bbeznd3r	93	44	labeled	label	VBN
cord-001734-bbeznd3r	93	45	sample	sample	NN
cord-001734-bbeznd3r	93	46	in	in	IN
cord-001734-bbeznd3r	93	47	the	the	DT
cord-001734-bbeznd3r	93	48	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	93	49	form	form	NN
cord-001734-bbeznd3r	93	50	,	,	,
cord-001734-bbeznd3r	93	51	and	and	CC
cord-001734-bbeznd3r	93	52	another	another	DT
cord-001734-bbeznd3r	93	53	after	after	IN
cord-001734-bbeznd3r	93	54	adding	add	VBG
cord-001734-bbeznd3r	93	55	ascorbic	ascorbic	NN
cord-001734-bbeznd3r	93	56	acid	acid	NN
cord-001734-bbeznd3r	93	57	(	(	-LRB-
cord-001734-bbeznd3r	93	58	to	to	IN
cord-001734-bbeznd3r	93	59	10	10	CD
cord-001734-bbeznd3r	93	60	mM	mm	CD
cord-001734-bbeznd3r	93	61	)	)	-RRB-
cord-001734-bbeznd3r	93	62	to	to	IN
cord-001734-bbeznd3r	93	63	the	the	DT
cord-001734-bbeznd3r	93	64	sample	sample	NN
cord-001734-bbeznd3r	93	65	to	to	TO
cord-001734-bbeznd3r	93	66	reduce	reduce	VB
cord-001734-bbeznd3r	93	67	the	the	DT
cord-001734-bbeznd3r	93	68	nitroxide	nitroxide	NN
cord-001734-bbeznd3r	93	69	,	,	,
cord-001734-bbeznd3r	93	70	yielding	yield	VBG
cord-001734-bbeznd3r	93	71	the	the	DT
cord-001734-bbeznd3r	93	72	diamagnetic	diamagnetic	JJ
cord-001734-bbeznd3r	93	73	sample	sample	NN
cord-001734-bbeznd3r	93	74	.	.	.
cord-001734-bbeznd3r	94	1	We	-PRON-	PRP
cord-001734-bbeznd3r	94	2	also	also	RB
cord-001734-bbeznd3r	94	3	acquired	acquire	VBD
cord-001734-bbeznd3r	94	4	HSQC	HSQC	NNP
cord-001734-bbeznd3r	94	5	spectra	spectra	NNP
cord-001734-bbeznd3r	94	6	for	for	IN
cord-001734-bbeznd3r	94	7	3	3	CD
cord-001734-bbeznd3r	94	8	corresponding	correspond	VBG
cord-001734-bbeznd3r	94	9	cysteine	cysteine	JJ
cord-001734-bbeznd3r	94	10	mutants	mutant	NNS
cord-001734-bbeznd3r	94	11	without	without	IN
cord-001734-bbeznd3r	94	12	spin	spin	NN
cord-001734-bbeznd3r	94	13	-	-	HYPH
cord-001734-bbeznd3r	94	14	labelling	labelling	NN
cord-001734-bbeznd3r	94	15	at	at	IN
cord-001734-bbeznd3r	94	16	the	the	DT
cord-001734-bbeznd3r	94	17	same	same	JJ
cord-001734-bbeznd3r	94	18	conditions	condition	NNS
cord-001734-bbeznd3r	94	19	and	and	CC
cord-001734-bbeznd3r	94	20	only	only	RB
cord-001734-bbeznd3r	94	21	several	several	JJ
cord-001734-bbeznd3r	94	22	HSQC	HSQC	NNP
cord-001734-bbeznd3r	94	23	peaks	peak	NNS
cord-001734-bbeznd3r	94	24	slightly	slightly	RB
cord-001734-bbeznd3r	94	25	shifted	shift	VBD
cord-001734-bbeznd3r	94	26	after	after	IN
cord-001734-bbeznd3r	94	27	spin	spin	NN
cord-001734-bbeznd3r	94	28	-	-	HYPH
cord-001734-bbeznd3r	94	29	labeling	labeling	NN
cord-001734-bbeznd3r	94	30	,	,	,
cord-001734-bbeznd3r	94	31	indicating	indicate	VBG
cord-001734-bbeznd3r	94	32	that	that	IN
cord-001734-bbeznd3r	94	33	the	the	DT
cord-001734-bbeznd3r	94	34	spin	spin	NN
cord-001734-bbeznd3r	94	35	-	-	HYPH
cord-001734-bbeznd3r	94	36	labeling	labeling	NN
cord-001734-bbeznd3r	94	37	would	would	MD
cord-001734-bbeznd3r	94	38	not	not	RB
cord-001734-bbeznd3r	94	39	significantly	significantly	RB
cord-001734-bbeznd3r	94	40	change	change	VB
cord-001734-bbeznd3r	94	41	the	the	DT
cord-001734-bbeznd3r	94	42	conformation	conformation	NN
cord-001734-bbeznd3r	94	43	.	.	.
cord-001734-bbeznd3r	95	1	The	the	DT
cord-001734-bbeznd3r	95	2	spectra	spectrum	NNS
cord-001734-bbeznd3r	95	3	were	be	VBD
cord-001734-bbeznd3r	95	4	subsequently	subsequently	RB
cord-001734-bbeznd3r	95	5	analyzed	analyze	VBN
cord-001734-bbeznd3r	95	6	to	to	TO
cord-001734-bbeznd3r	95	7	obtain	obtain	VB
cord-001734-bbeznd3r	95	8	intensity	intensity	NN
cord-001734-bbeznd3r	95	9	ratios	ratio	NNS
cord-001734-bbeznd3r	95	10	of	of	IN
cord-001734-bbeznd3r	95	11	HSQC	HSQC	NNP
cord-001734-bbeznd3r	95	12	peaks	peak	NNS
cord-001734-bbeznd3r	95	13	in	in	IN
cord-001734-bbeznd3r	95	14	the	the	DT
cord-001734-bbeznd3r	95	15	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	95	16	and	and	CC
cord-001734-bbeznd3r	95	17	diamagnetic	diamagnetic	JJ
cord-001734-bbeznd3r	95	18	forms	form	NNS
cord-001734-bbeznd3r	95	19	using	use	VBG
cord-001734-bbeznd3r	95	20	the	the	DT
cord-001734-bbeznd3r	95	21	programs	program	NNS
cord-001734-bbeznd3r	95	22	nmrPipe	nmrpipe	LS
cord-001734-bbeznd3r	95	23	[	[	-LRB-
cord-001734-bbeznd3r	95	24	24	24	CD
cord-001734-bbeznd3r	95	25	]	]	-RRB-
cord-001734-bbeznd3r	95	26	.	.	.
cord-001734-bbeznd3r	96	1	Protein	protein	NN
cord-001734-bbeznd3r	96	2	structures	structure	NNS
cord-001734-bbeznd3r	96	3	were	be	VBD
cord-001734-bbeznd3r	96	4	displayed	display	VBN
cord-001734-bbeznd3r	96	5	by	by	IN
cord-001734-bbeznd3r	96	6	PyMol	PyMol	NNP
cord-001734-bbeznd3r	96	7	molecular	molecular	JJ
cord-001734-bbeznd3r	96	8	graphics	graphic	NNS
cord-001734-bbeznd3r	96	9	system	system	NN
cord-001734-bbeznd3r	96	10	(	(	-LRB-
cord-001734-bbeznd3r	96	11	W.	W.	NNP
cord-001734-bbeznd3r	96	12	L.	L.	NNP
cord-001734-bbeznd3r	96	13	DeLano	DeLano	NNP
cord-001734-bbeznd3r	96	14	,	,	,
cord-001734-bbeznd3r	96	15	DeLano	DeLano	NNP
cord-001734-bbeznd3r	96	16	Scientific	Scientific	NNP
cord-001734-bbeznd3r	96	17	LLC	LLC	NNP
cord-001734-bbeznd3r	96	18	,	,	,
cord-001734-bbeznd3r	96	19	San	San	NNP
cord-001734-bbeznd3r	96	20	Carlos	Carlos	NNP
cord-001734-bbeznd3r	96	21	,	,	,
cord-001734-bbeznd3r	96	22	CA	CA	NNP
cord-001734-bbeznd3r	96	23	)	)	-RRB-
cord-001734-bbeznd3r	96	24	.	.	.
cord-001734-bbeznd3r	97	1	The	the	DT
cord-001734-bbeznd3r	97	2	crystal	crystal	JJ
cord-001734-bbeznd3r	97	3	structure	structure	NN
cord-001734-bbeznd3r	97	4	of	of	IN
cord-001734-bbeznd3r	97	5	the	the	DT
cord-001734-bbeznd3r	97	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	97	7	-	-	HYPH
cord-001734-bbeznd3r	97	8	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	97	9	complex	complex	NN
cord-001734-bbeznd3r	97	10	(	(	-LRB-
cord-001734-bbeznd3r	97	11	PDB	PDB	NNP
cord-001734-bbeznd3r	97	12	code	code	NN
cord-001734-bbeznd3r	97	13	:	:	:
cord-001734-bbeznd3r	97	14	2FOM	2fom	LS
cord-001734-bbeznd3r	97	15	)	)	-RRB-
cord-001734-bbeznd3r	97	16	with	with	IN
cord-001734-bbeznd3r	97	17	an	an	DT
cord-001734-bbeznd3r	97	18	open	open	JJ
cord-001734-bbeznd3r	97	19	conformation	conformation	NN
cord-001734-bbeznd3r	97	20	[	[	-LRB-
cord-001734-bbeznd3r	97	21	7	7	CD
cord-001734-bbeznd3r	97	22	]	]	-RRB-
cord-001734-bbeznd3r	97	23	was	be	VBD
cord-001734-bbeznd3r	97	24	selected	select	VBN
cord-001734-bbeznd3r	97	25	for	for	IN
cord-001734-bbeznd3r	97	26	molecular	molecular	JJ
cord-001734-bbeznd3r	97	27	dynamics	dynamic	NNS
cord-001734-bbeznd3r	97	28	simulations	simulation	NNS
cord-001734-bbeznd3r	97	29	.	.	.
cord-001734-bbeznd3r	98	1	As	as	IN
cord-001734-bbeznd3r	98	2	NS2B	NS2B	NNP
cord-001734-bbeznd3r	98	3	residues	residue	NNS
cord-001734-bbeznd3r	98	4	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	98	5	are	be	VBP
cord-001734-bbeznd3r	98	6	missing	miss	VBG
cord-001734-bbeznd3r	98	7	in	in	IN
cord-001734-bbeznd3r	98	8	the	the	DT
cord-001734-bbeznd3r	98	9	crystal	crystal	NN
cord-001734-bbeznd3r	98	10	structure	structure	NN
cord-001734-bbeznd3r	98	11	,	,	,
cord-001734-bbeznd3r	98	12	those	those	DT
cord-001734-bbeznd3r	98	13	residues	residue	NNS
cord-001734-bbeznd3r	98	14	were	be	VBD
cord-001734-bbeznd3r	98	15	added	add	VBN
cord-001734-bbeznd3r	98	16	and	and	CC
cord-001734-bbeznd3r	98	17	the	the	DT
cord-001734-bbeznd3r	98	18	obtained	obtain	VBN
cord-001734-bbeznd3r	98	19	structure	structure	NN
cord-001734-bbeznd3r	98	20	was	be	VBD
cord-001734-bbeznd3r	98	21	post	post	RB
cord-001734-bbeznd3r	98	22	-	-	JJ
cord-001734-bbeznd3r	98	23	processed	process	VBN
cord-001734-bbeznd3r	98	24	as	as	IN
cord-001734-bbeznd3r	98	25	previously	previously	RB
cord-001734-bbeznd3r	98	26	described	describe	VBN
cord-001734-bbeznd3r	98	27	[	[	-LRB-
cord-001734-bbeznd3r	98	28	20	20	CD
cord-001734-bbeznd3r	98	29	,	,	,
cord-001734-bbeznd3r	98	30	21	21	CD
cord-001734-bbeznd3r	98	31	]	]	-RRB-
cord-001734-bbeznd3r	98	32	.	.	.
cord-001734-bbeznd3r	99	1	The	the	DT
cord-001734-bbeznd3r	99	2	simulation	simulation	NN
cord-001734-bbeznd3r	99	3	cell	cell	NN
cord-001734-bbeznd3r	99	4	is	be	VBZ
cord-001734-bbeznd3r	99	5	a	a	DT
cord-001734-bbeznd3r	99	6	periodic	periodic	JJ
cord-001734-bbeznd3r	99	7	cubic	cubic	JJ
cord-001734-bbeznd3r	99	8	box	box	NN
cord-001734-bbeznd3r	99	9	with	with	IN
cord-001734-bbeznd3r	99	10	a	a	DT
cord-001734-bbeznd3r	99	11	minimum	minimum	JJ
cord-001734-bbeznd3r	99	12	distance	distance	NN
cord-001734-bbeznd3r	99	13	of	of	IN
cord-001734-bbeznd3r	99	14	10	10	CD
cord-001734-bbeznd3r	99	15	Å	å	NN
cord-001734-bbeznd3r	99	16	between	between	IN
cord-001734-bbeznd3r	99	17	the	the	DT
cord-001734-bbeznd3r	99	18	protein	protein	NN
cord-001734-bbeznd3r	99	19	and	and	CC
cord-001734-bbeznd3r	99	20	the	the	DT
cord-001734-bbeznd3r	99	21	box	box	NN
cord-001734-bbeznd3r	99	22	walls	wall	NNS
cord-001734-bbeznd3r	99	23	to	to	TO
cord-001734-bbeznd3r	99	24	ensure	ensure	VB
cord-001734-bbeznd3r	99	25	the	the	DT
cord-001734-bbeznd3r	99	26	protein	protein	NN
cord-001734-bbeznd3r	99	27	would	would	MD
cord-001734-bbeznd3r	99	28	not	not	RB
cord-001734-bbeznd3r	99	29	directly	directly	RB
cord-001734-bbeznd3r	99	30	interact	interact	VB
cord-001734-bbeznd3r	99	31	with	with	IN
cord-001734-bbeznd3r	99	32	its	-PRON-	PRP$
cord-001734-bbeznd3r	99	33	own	own	JJ
cord-001734-bbeznd3r	99	34	periodic	periodic	JJ
cord-001734-bbeznd3r	99	35	images	image	NNS
cord-001734-bbeznd3r	99	36	given	give	VBN
cord-001734-bbeznd3r	99	37	the	the	DT
cord-001734-bbeznd3r	99	38	cutoff	cutoff	NN
cord-001734-bbeznd3r	99	39	.	.	.
cord-001734-bbeznd3r	100	1	The	the	DT
cord-001734-bbeznd3r	100	2	water	water	NN
cord-001734-bbeznd3r	100	3	molecules	molecule	NNS
cord-001734-bbeznd3r	100	4	,	,	,
cord-001734-bbeznd3r	100	5	described	describe	VBN
cord-001734-bbeznd3r	100	6	using	use	VBG
cord-001734-bbeznd3r	100	7	the	the	DT
cord-001734-bbeznd3r	100	8	TIP3P	tip3p	CD
cord-001734-bbeznd3r	100	9	model	model	NN
cord-001734-bbeznd3r	100	10	,	,	,
cord-001734-bbeznd3r	100	11	were	be	VBD
cord-001734-bbeznd3r	100	12	filled	fill	VBN
cord-001734-bbeznd3r	100	13	in	in	IN
cord-001734-bbeznd3r	100	14	the	the	DT
cord-001734-bbeznd3r	100	15	periodic	periodic	JJ
cord-001734-bbeznd3r	100	16	cubic	cubic	JJ
cord-001734-bbeznd3r	100	17	box	box	NN
cord-001734-bbeznd3r	100	18	for	for	IN
cord-001734-bbeznd3r	100	19	the	the	DT
cord-001734-bbeznd3r	100	20	all	all	DT
cord-001734-bbeznd3r	100	21	atom	atom	NN
cord-001734-bbeznd3r	100	22	simulation	simulation	NN
cord-001734-bbeznd3r	100	23	.	.	.
cord-001734-bbeznd3r	101	1	6	6	CD
cord-001734-bbeznd3r	102	1	Na	Na	NNP
cord-001734-bbeznd3r	102	2	+	+	CC
cord-001734-bbeznd3r	102	3	ions	ion	NNS
cord-001734-bbeznd3r	102	4	were	be	VBD
cord-001734-bbeznd3r	102	5	randomly	randomly	RB
cord-001734-bbeznd3r	102	6	placed	place	VBN
cord-001734-bbeznd3r	102	7	to	to	TO
cord-001734-bbeznd3r	102	8	neutralize	neutralize	VB
cord-001734-bbeznd3r	102	9	the	the	DT
cord-001734-bbeznd3r	102	10	charge	charge	NN
cord-001734-bbeznd3r	102	11	in	in	IN
cord-001734-bbeznd3r	102	12	MD	MD	NNP
cord-001734-bbeznd3r	102	13	system	system	NN
cord-001734-bbeznd3r	102	14	.	.	.
cord-001734-bbeznd3r	103	1	Three	three	CD
cord-001734-bbeznd3r	103	2	independent	independent	JJ
cord-001734-bbeznd3r	103	3	20-ns	20-ns	CD
cord-001734-bbeznd3r	103	4	MD	MD	NNP
cord-001734-bbeznd3r	103	5	simulations	simulation	NNS
cord-001734-bbeznd3r	103	6	for	for	IN
cord-001734-bbeznd3r	103	7	either	either	DT
cord-001734-bbeznd3r	103	8	NS2B	NS2B	NNP
cord-001734-bbeznd3r	103	9	-	-	HYPH
cord-001734-bbeznd3r	103	10	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	103	11	complex	complex	NN
cord-001734-bbeznd3r	103	12	or	or	CC
cord-001734-bbeznd3r	103	13	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	103	14	alone	alone	RB
cord-001734-bbeznd3r	103	15	were	be	VBD
cord-001734-bbeznd3r	103	16	performed	perform	VBN
cord-001734-bbeznd3r	103	17	with	with	IN
cord-001734-bbeznd3r	103	18	the	the	DT
cord-001734-bbeznd3r	103	19	program	program	NN
cord-001734-bbeznd3r	103	20	GROMACS	GROMACS	NNP
cord-001734-bbeznd3r	103	21	[	[	-LRB-
cord-001734-bbeznd3r	103	22	27	27	CD
cord-001734-bbeznd3r	103	23	]	]	-RRB-
cord-001734-bbeznd3r	103	24	with	with	IN
cord-001734-bbeznd3r	103	25	the	the	DT
cord-001734-bbeznd3r	103	26	AMBER-03	amber-03	CD
cord-001734-bbeznd3r	103	27	[	[	-LRB-
cord-001734-bbeznd3r	103	28	28	28	CD
cord-001734-bbeznd3r	103	29	]	]	-RRB-
cord-001734-bbeznd3r	103	30	all	all	DT
cord-001734-bbeznd3r	103	31	-	-	HYPH
cord-001734-bbeznd3r	103	32	atom	atom	NN
cord-001734-bbeznd3r	103	33	force	force	NN
cord-001734-bbeznd3r	103	34	field	field	NN
cord-001734-bbeznd3r	103	35	.	.	.
cord-001734-bbeznd3r	104	1	The	the	DT
cord-001734-bbeznd3r	104	2	long	long	JJ
cord-001734-bbeznd3r	104	3	-	-	HYPH
cord-001734-bbeznd3r	104	4	range	range	NN
cord-001734-bbeznd3r	104	5	electrostatic	electrostatic	JJ
cord-001734-bbeznd3r	104	6	interactions	interaction	NNS
cord-001734-bbeznd3r	104	7	were	be	VBD
cord-001734-bbeznd3r	104	8	treated	treat	VBN
cord-001734-bbeznd3r	104	9	using	use	VBG
cord-001734-bbeznd3r	104	10	the	the	DT
cord-001734-bbeznd3r	104	11	fast	fast	JJ
cord-001734-bbeznd3r	104	12	particle	particle	NN
cord-001734-bbeznd3r	104	13	-	-	HYPH
cord-001734-bbeznd3r	104	14	mesh	mesh	NN
cord-001734-bbeznd3r	104	15	Ewald	Ewald	NNP
cord-001734-bbeznd3r	104	16	summation	summation	NN
cord-001734-bbeznd3r	104	17	method	method	NN
cord-001734-bbeznd3r	104	18	[	[	-LRB-
cord-001734-bbeznd3r	104	19	29	29	CD
cord-001734-bbeznd3r	104	20	]	]	-RRB-
cord-001734-bbeznd3r	104	21	,	,	,
cord-001734-bbeznd3r	104	22	with	with	IN
cord-001734-bbeznd3r	104	23	the	the	DT
cord-001734-bbeznd3r	104	24	real	real	JJ
cord-001734-bbeznd3r	104	25	space	space	NN
cord-001734-bbeznd3r	104	26	cutoff	cutoff	NN
cord-001734-bbeznd3r	104	27	of	of	IN
cord-001734-bbeznd3r	104	28	9	9	CD
cord-001734-bbeznd3r	104	29	Å	å	NN
cord-001734-bbeznd3r	104	30	and	and	CC
cord-001734-bbeznd3r	104	31	a	a	DT
cord-001734-bbeznd3r	104	32	cutoff	cutoff	NN
cord-001734-bbeznd3r	104	33	of	of	IN
cord-001734-bbeznd3r	104	34	14	14	CD
cord-001734-bbeznd3r	104	35	Å	å	NN
cord-001734-bbeznd3r	104	36	was	be	VBD
cord-001734-bbeznd3r	104	37	used	use	VBN
cord-001734-bbeznd3r	104	38	for	for	IN
cord-001734-bbeznd3r	104	39	the	the	DT
cord-001734-bbeznd3r	104	40	calculation	calculation	NN
cord-001734-bbeznd3r	104	41	of	of	IN
cord-001734-bbeznd3r	104	42	van	van	NNP
cord-001734-bbeznd3r	104	43	der	der	NNP
cord-001734-bbeznd3r	104	44	Waals	Waals	NNP
cord-001734-bbeznd3r	104	45	interactions	interaction	NNS
cord-001734-bbeznd3r	104	46	.	.	.
cord-001734-bbeznd3r	105	1	The	the	DT
cord-001734-bbeznd3r	105	2	temperature	temperature	NN
cord-001734-bbeznd3r	105	3	during	during	IN
cord-001734-bbeznd3r	105	4	the	the	DT
cord-001734-bbeznd3r	105	5	simulations	simulation	NNS
cord-001734-bbeznd3r	105	6	was	be	VBD
cord-001734-bbeznd3r	105	7	kept	keep	VBN
cord-001734-bbeznd3r	105	8	constant	constant	JJ
cord-001734-bbeznd3r	105	9	at	at	IN
cord-001734-bbeznd3r	105	10	300	300	CD
cord-001734-bbeznd3r	105	11	K	K	NNP
cord-001734-bbeznd3r	105	12	by	by	IN
cord-001734-bbeznd3r	105	13	Berendsen	Berendsen	NNP
cord-001734-bbeznd3r	105	14	's	's	POS
cord-001734-bbeznd3r	105	15	coupling	coupling	NN
cord-001734-bbeznd3r	105	16	.	.	.
cord-001734-bbeznd3r	106	1	The	the	DT
cord-001734-bbeznd3r	106	2	pressure	pressure	NN
cord-001734-bbeznd3r	106	3	was	be	VBD
cord-001734-bbeznd3r	106	4	held	hold	VBN
cord-001734-bbeznd3r	106	5	at	at	IN
cord-001734-bbeznd3r	106	6	1	1	CD
cord-001734-bbeznd3r	106	7	bar	bar	NN
cord-001734-bbeznd3r	106	8	.	.	.
cord-001734-bbeznd3r	107	1	The	the	DT
cord-001734-bbeznd3r	107	2	isothermal	isothermal	JJ
cord-001734-bbeznd3r	107	3	compressibility	compressibility	NN
cord-001734-bbeznd3r	107	4	was	be	VBD
cord-001734-bbeznd3r	107	5	4.5	4.5	CD
cord-001734-bbeznd3r	107	6	Ã	ã	NN
cord-001734-bbeznd3r	107	7	10	10	CD
cord-001734-bbeznd3r	107	8	−5	−5	NN
cord-001734-bbeznd3r	107	9	bar	bar	NN
cord-001734-bbeznd3r	107	10	-1	-1	NN
cord-001734-bbeznd3r	107	11	.	.	.
cord-001734-bbeznd3r	108	1	The	the	DT
cord-001734-bbeznd3r	108	2	time	time	NN
cord-001734-bbeznd3r	108	3	step	step	NN
cord-001734-bbeznd3r	108	4	was	be	VBD
cord-001734-bbeznd3r	108	5	set	set	VBN
cord-001734-bbeznd3r	108	6	as	as	IN
cord-001734-bbeznd3r	108	7	2	2	CD
cord-001734-bbeznd3r	108	8	fs	f	NNS
cord-001734-bbeznd3r	108	9	.	.	.
cord-001734-bbeznd3r	109	1	All	all	DT
cord-001734-bbeznd3r	109	2	bond	bond	NN
cord-001734-bbeznd3r	109	3	lengths	length	NNS
cord-001734-bbeznd3r	109	4	including	include	VBG
cord-001734-bbeznd3r	109	5	hydrogen	hydrogen	NN
cord-001734-bbeznd3r	109	6	atoms	atom	NNS
cord-001734-bbeznd3r	109	7	were	be	VBD
cord-001734-bbeznd3r	109	8	constrained	constrain	VBN
cord-001734-bbeznd3r	109	9	by	by	IN
cord-001734-bbeznd3r	109	10	the	the	DT
cord-001734-bbeznd3r	109	11	LINCS	LINCS	NNP
cord-001734-bbeznd3r	109	12	algorithm	algorithm	NN
cord-001734-bbeznd3r	109	13	[	[	-LRB-
cord-001734-bbeznd3r	109	14	29	29	CD
cord-001734-bbeznd3r	109	15	]	]	-RRB-
cord-001734-bbeznd3r	109	16	.	.	.
cord-001734-bbeznd3r	110	1	Prior	prior	RB
cord-001734-bbeznd3r	110	2	to	to	IN
cord-001734-bbeznd3r	110	3	MD	MD	NNP
cord-001734-bbeznd3r	110	4	simulations	simulation	NNS
cord-001734-bbeznd3r	110	5	,	,	,
cord-001734-bbeznd3r	110	6	all	all	PDT
cord-001734-bbeznd3r	110	7	the	the	DT
cord-001734-bbeznd3r	110	8	initial	initial	JJ
cord-001734-bbeznd3r	110	9	structures	structure	NNS
cord-001734-bbeznd3r	110	10	were	be	VBD
cord-001734-bbeznd3r	110	11	relaxed	relax	VBN
cord-001734-bbeznd3r	110	12	by	by	IN
cord-001734-bbeznd3r	110	13	500	500	CD
cord-001734-bbeznd3r	110	14	steps	step	NNS
cord-001734-bbeznd3r	110	15	of	of	IN
cord-001734-bbeznd3r	110	16	energy	energy	NN
cord-001734-bbeznd3r	110	17	minimization	minimization	NN
cord-001734-bbeznd3r	110	18	using	use	VBG
cord-001734-bbeznd3r	110	19	the	the	DT
cord-001734-bbeznd3r	110	20	steepest	steep	JJS
cord-001734-bbeznd3r	110	21	descent	descent	NN
cord-001734-bbeznd3r	110	22	algorithm	algorithm	NN
cord-001734-bbeznd3r	110	23	,	,	,
cord-001734-bbeznd3r	110	24	followed	follow	VBN
cord-001734-bbeznd3r	110	25	by	by	IN
cord-001734-bbeznd3r	110	26	100	100	CD
cord-001734-bbeznd3r	110	27	ps	ps	NN
cord-001734-bbeznd3r	110	28	equilibration	equilibration	NN
cord-001734-bbeznd3r	110	29	with	with	IN
cord-001734-bbeznd3r	110	30	a	a	DT
cord-001734-bbeznd3r	110	31	harmonic	harmonic	JJ
cord-001734-bbeznd3r	110	32	restraint	restraint	NN
cord-001734-bbeznd3r	110	33	potential	potential	NN
cord-001734-bbeznd3r	110	34	applied	apply	VBD
cord-001734-bbeznd3r	110	35	to	to	IN
cord-001734-bbeznd3r	110	36	all	all	PDT
cord-001734-bbeznd3r	110	37	the	the	DT
cord-001734-bbeznd3r	110	38	heavy	heavy	JJ
cord-001734-bbeznd3r	110	39	atoms	atom	NNS
cord-001734-bbeznd3r	110	40	of	of	IN
cord-001734-bbeznd3r	110	41	the	the	DT
cord-001734-bbeznd3r	110	42	protease	protease	NN
cord-001734-bbeznd3r	110	43	.	.	.
cord-001734-bbeznd3r	111	1	As	as	IN
cord-001734-bbeznd3r	111	2	the	the	DT
cord-001734-bbeznd3r	111	3	20-ns	20-ns	CD
cord-001734-bbeznd3r	111	4	simulations	simulation	NNS
cord-001734-bbeznd3r	111	5	can	can	MD
cord-001734-bbeznd3r	111	6	not	not	RB
cord-001734-bbeznd3r	111	7	reproduce	reproduce	VB
cord-001734-bbeznd3r	111	8	the	the	DT
cord-001734-bbeznd3r	111	9	folding	folding	NN
cord-001734-bbeznd3r	111	10	-	-	HYPH
cord-001734-bbeznd3r	111	11	unfolding	unfold	VBG
cord-001734-bbeznd3r	111	12	event	event	NN
cord-001734-bbeznd3r	111	13	,	,	,
cord-001734-bbeznd3r	111	14	so	so	RB
cord-001734-bbeznd3r	111	15	here	here	RB
cord-001734-bbeznd3r	111	16	we	-PRON-	PRP
cord-001734-bbeznd3r	111	17	attempted	attempt	VBD
cord-001734-bbeznd3r	111	18	to	to	TO
cord-001734-bbeznd3r	111	19	capture	capture	VB
cord-001734-bbeznd3r	111	20	the	the	DT
cord-001734-bbeznd3r	111	21	low	low	JJ
cord-001734-bbeznd3r	111	22	-	-	HYPH
cord-001734-bbeznd3r	111	23	frequency	frequency	NN
cord-001734-bbeznd3r	111	24	correlation	correlation	NN
cord-001734-bbeznd3r	111	25	motions	motion	NNS
cord-001734-bbeznd3r	111	26	by	by	IN
cord-001734-bbeznd3r	111	27	a	a	DT
cord-001734-bbeznd3r	111	28	recently	recently	RB
cord-001734-bbeznd3r	111	29	established	establish	VBN
cord-001734-bbeznd3r	111	30	approach	approach	NN
cord-001734-bbeznd3r	111	31	called	call	VBN
cord-001734-bbeznd3r	111	32	MutInf	MutInf	NNP
cord-001734-bbeznd3r	111	33	[	[	-LRB-
cord-001734-bbeznd3r	111	34	30	30	CD
cord-001734-bbeznd3r	111	35	]	]	-RRB-
cord-001734-bbeznd3r	111	36	.	.	.
cord-001734-bbeznd3r	112	1	MutInf	MutInf	NNP
cord-001734-bbeznd3r	112	2	represents	represent	VBZ
cord-001734-bbeznd3r	112	3	an	an	DT
cord-001734-bbeznd3r	112	4	entropy	entropy	NN
cord-001734-bbeznd3r	112	5	-	-	HYPH
cord-001734-bbeznd3r	112	6	based	base	VBN
cord-001734-bbeznd3r	112	7	approach	approach	NN
cord-001734-bbeznd3r	112	8	to	to	TO
cord-001734-bbeznd3r	112	9	analyze	analyze	VB
cord-001734-bbeznd3r	112	10	ensembles	ensemble	NNS
cord-001734-bbeznd3r	112	11	of	of	IN
cord-001734-bbeznd3r	112	12	protein	protein	NN
cord-001734-bbeznd3r	112	13	conformers	conformer	NNS
cord-001734-bbeznd3r	112	14	,	,	,
cord-001734-bbeznd3r	112	15	such	such	JJ
cord-001734-bbeznd3r	112	16	as	as	IN
cord-001734-bbeznd3r	112	17	those	those	DT
cord-001734-bbeznd3r	112	18	from	from	IN
cord-001734-bbeznd3r	112	19	molecular	molecular	JJ
cord-001734-bbeznd3r	112	20	dynamics	dynamic	NNS
cord-001734-bbeznd3r	112	21	simulations	simulation	NNS
cord-001734-bbeznd3r	112	22	by	by	IN
cord-001734-bbeznd3r	112	23	using	use	VBG
cord-001734-bbeznd3r	112	24	internal	internal	JJ
cord-001734-bbeznd3r	112	25	coordinates	coordinate	NNS
cord-001734-bbeznd3r	112	26	and	and	CC
cord-001734-bbeznd3r	112	27	focusing	focus	VBG
cord-001734-bbeznd3r	112	28	on	on	IN
cord-001734-bbeznd3r	112	29	dihedral	dihedral	JJ
cord-001734-bbeznd3r	112	30	angles	angle	NNS
cord-001734-bbeznd3r	112	31	.	.	.
cord-001734-bbeznd3r	113	1	In	in	IN
cord-001734-bbeznd3r	113	2	particular	particular	JJ
cord-001734-bbeznd3r	113	3	,	,	,
cord-001734-bbeznd3r	113	4	this	this	DT
cord-001734-bbeznd3r	113	5	approach	approach	NN
cord-001734-bbeznd3r	113	6	is	be	VBZ
cord-001734-bbeznd3r	113	7	even	even	RB
cord-001734-bbeznd3r	113	8	applicable	applicable	JJ
cord-001734-bbeznd3r	113	9	for	for	IN
cord-001734-bbeznd3r	113	10	detecting	detect	VBG
cord-001734-bbeznd3r	113	11	conformational	conformational	JJ
cord-001734-bbeznd3r	113	12	changes	change	NNS
cord-001734-bbeznd3r	113	13	which	which	WDT
cord-001734-bbeznd3r	113	14	are	be	VBP
cord-001734-bbeznd3r	113	15	subtle	subtle	JJ
cord-001734-bbeznd3r	113	16	in	in	IN
cord-001734-bbeznd3r	113	17	the	the	DT
cord-001734-bbeznd3r	113	18	short	short	JJ
cord-001734-bbeznd3r	113	19	MD	MD	NNP
cord-001734-bbeznd3r	113	20	simulations	simulation	NNS
cord-001734-bbeznd3r	113	21	because	because	IN
cord-001734-bbeznd3r	113	22	the	the	DT
cord-001734-bbeznd3r	113	23	coupling	coupling	NN
cord-001734-bbeznd3r	113	24	is	be	VBZ
cord-001734-bbeznd3r	113	25	mostly	mostly	RB
cord-001734-bbeznd3r	113	26	entropic	entropic	JJ
cord-001734-bbeznd3r	113	27	in	in	IN
cord-001734-bbeznd3r	113	28	nature	nature	NN
cord-001734-bbeznd3r	113	29	[	[	-LRB-
cord-001734-bbeznd3r	113	30	30	30	CD
cord-001734-bbeznd3r	113	31	]	]	-RRB-
cord-001734-bbeznd3r	113	32	.	.	.
cord-001734-bbeznd3r	114	1	Briefly	briefly	RB
cord-001734-bbeznd3r	114	2	,	,	,
cord-001734-bbeznd3r	114	3	this	this	DT
cord-001734-bbeznd3r	114	4	approach	approach	NN
cord-001734-bbeznd3r	114	5	utilizes	utilize	VBZ
cord-001734-bbeznd3r	114	6	second	second	JJ
cord-001734-bbeznd3r	114	7	-	-	HYPH
cord-001734-bbeznd3r	114	8	order	order	NN
cord-001734-bbeznd3r	114	9	terms	term	NNS
cord-001734-bbeznd3r	114	10	from	from	IN
cord-001734-bbeznd3r	114	11	the	the	DT
cord-001734-bbeznd3r	114	12	configurational	configurational	NNP
cord-001734-bbeznd3r	114	13	entropy	entropy	NNP
cord-001734-bbeznd3r	114	14	expansion	expansion	NN
cord-001734-bbeznd3r	114	15	,	,	,
cord-001734-bbeznd3r	114	16	called	call	VBD
cord-001734-bbeznd3r	114	17	the	the	DT
cord-001734-bbeznd3r	114	18	mutual	mutual	JJ
cord-001734-bbeznd3r	114	19	information	information	NN
cord-001734-bbeznd3r	114	20	,	,	,
cord-001734-bbeznd3r	114	21	to	to	TO
cord-001734-bbeznd3r	114	22	identify	identify	VB
cord-001734-bbeznd3r	114	23	pairs	pair	NNS
cord-001734-bbeznd3r	114	24	of	of	IN
cord-001734-bbeznd3r	114	25	residues	residue	NNS
cord-001734-bbeznd3r	114	26	with	with	IN
cord-001734-bbeznd3r	114	27	correlated	correlate	VBN
cord-001734-bbeznd3r	114	28	conformations	conformation	NNS
cord-001734-bbeznd3r	114	29	,	,	,
cord-001734-bbeznd3r	114	30	or	or	CC
cord-001734-bbeznd3r	114	31	correlated	correlate	VBN
cord-001734-bbeznd3r	114	32	motions	motion	NNS
cord-001734-bbeznd3r	114	33	,	,	,
cord-001734-bbeznd3r	114	34	in	in	IN
cord-001734-bbeznd3r	114	35	an	an	DT
cord-001734-bbeznd3r	114	36	equilibrium	equilibrium	NN
cord-001734-bbeznd3r	114	37	ensemble	ensemble	NN
cord-001734-bbeznd3r	114	38	[	[	-LRB-
cord-001734-bbeznd3r	114	39	30	30	CD
cord-001734-bbeznd3r	114	40	]	]	-RRB-
cord-001734-bbeznd3r	114	41	.	.	.
cord-001734-bbeznd3r	115	1	In	in	IN
cord-001734-bbeznd3r	115	2	the	the	DT
cord-001734-bbeznd3r	115	3	present	present	JJ
cord-001734-bbeznd3r	115	4	study	study	NN
cord-001734-bbeznd3r	115	5	,	,	,
cord-001734-bbeznd3r	115	6	the	the	DT
cord-001734-bbeznd3r	115	7	normalized	normalized	JJ
cord-001734-bbeznd3r	115	8	matrix	matrix	NN
cord-001734-bbeznd3r	115	9	values	value	NNS
cord-001734-bbeznd3r	115	10	were	be	VBD
cord-001734-bbeznd3r	115	11	used	use	VBN
cord-001734-bbeznd3r	115	12	,	,	,
cord-001734-bbeznd3r	115	13	and	and	CC
cord-001734-bbeznd3r	115	14	0.3	0.3	CD
cord-001734-bbeznd3r	115	15	was	be	VBD
cord-001734-bbeznd3r	115	16	set	set	VBN
cord-001734-bbeznd3r	115	17	up	up	RP
cord-001734-bbeznd3r	115	18	to	to	TO
cord-001734-bbeznd3r	115	19	be	be	VB
cord-001734-bbeznd3r	115	20	the	the	DT
cord-001734-bbeznd3r	115	21	threshold	threshold	NN
cord-001734-bbeznd3r	115	22	value	value	NN
cord-001734-bbeznd3r	115	23	to	to	TO
cord-001734-bbeznd3r	115	24	determine	determine	VB
cord-001734-bbeznd3r	115	25	the	the	DT
cord-001734-bbeznd3r	115	26	pairs	pair	NNS
cord-001734-bbeznd3r	115	27	of	of	IN
cord-001734-bbeznd3r	115	28	highly	highly	RB
cord-001734-bbeznd3r	115	29	correlated	correlate	VBN
cord-001734-bbeznd3r	115	30	residues	residue	NNS
cord-001734-bbeznd3r	115	31	.	.	.
cord-001734-bbeznd3r	116	1	The	the	DT
cord-001734-bbeznd3r	116	2	residue	residue	NN
cord-001734-bbeznd3r	116	3	pairs	pair	NNS
cord-001734-bbeznd3r	116	4	with	with	IN
cord-001734-bbeznd3r	116	5	correlated	correlate	VBN
cord-001734-bbeznd3r	116	6	values	value	NNS
cord-001734-bbeznd3r	116	7	!	!	.
cord-001734-bbeznd3r	117	1	0.3	0.3	CD
cord-001734-bbeznd3r	117	2	make	make	VB
cord-001734-bbeznd3r	117	3	up	up	RP
cord-001734-bbeznd3r	117	4	the	the	DT
cord-001734-bbeznd3r	117	5	top	top	JJ
cord-001734-bbeznd3r	117	6	1	1	CD
cord-001734-bbeznd3r	117	7	%	%	NN
cord-001734-bbeznd3r	117	8	of	of	IN
cord-001734-bbeznd3r	117	9	the	the	DT
cord-001734-bbeznd3r	117	10	entire	entire	JJ
cord-001734-bbeznd3r	117	11	matrix	matrix	NN
cord-001734-bbeznd3r	117	12	.	.	.
cord-001734-bbeznd3r	118	1	DNA	dna	NN
cord-001734-bbeznd3r	118	2	fragments	fragment	NNS
cord-001734-bbeznd3r	119	1	encoding	encode	VBG
cord-001734-bbeznd3r	120	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	120	2	(	(	-LRB-
cord-001734-bbeznd3r	120	3	48	48	CD
cord-001734-bbeznd3r	120	4	-	-	SYM
cord-001734-bbeznd3r	120	5	100	100	CD
cord-001734-bbeznd3r	120	6	)	)	-RRB-
cord-001734-bbeznd3r	120	7	and	and	CC
cord-001734-bbeznd3r	120	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	120	9	(	(	-LRB-
cord-001734-bbeznd3r	120	10	14	14	CD
cord-001734-bbeznd3r	120	11	-	-	SYM
cord-001734-bbeznd3r	120	12	185	185	CD
cord-001734-bbeznd3r	120	13	)	)	-RRB-
cord-001734-bbeznd3r	120	14	were	be	VBD
cord-001734-bbeznd3r	120	15	sub	sub	NN
cord-001734-bbeznd3r	120	16	-	-	JJ
cord-001734-bbeznd3r	120	17	cloned	clone	VBN
cord-001734-bbeznd3r	120	18	into	into	IN
cord-001734-bbeznd3r	120	19	the	the	DT
cord-001734-bbeznd3r	120	20	expression	expression	NN
cord-001734-bbeznd3r	120	21	vectors	vector	NNS
cord-001734-bbeznd3r	120	22	pGEX-4T1	pgex-4t1	NN
cord-001734-bbeznd3r	120	23	and	and	CC
cord-001734-bbeznd3r	120	24	pET-28	pet-28	CD
cord-001734-bbeznd3r	120	25	respectively	respectively	RB
cord-001734-bbeznd3r	120	26	and	and	CC
cord-001734-bbeznd3r	120	27	subsequently	subsequently	RB
cord-001734-bbeznd3r	120	28	expressed	express	VBN
cord-001734-bbeznd3r	120	29	in	in	IN
cord-001734-bbeznd3r	120	30	E.	E.	NNP
cord-001734-bbeznd3r	120	31	coli	coli	NNS
cord-001734-bbeznd3r	121	1	BL21	BL21	NNP
cord-001734-bbeznd3r	121	2	(	(	-LRB-
cord-001734-bbeznd3r	121	3	DE3	DE3	NNP
cord-001734-bbeznd3r	121	4	)	)	-RRB-
cord-001734-bbeznd3r	121	5	Star	Star	NNP
cord-001734-bbeznd3r	121	6	cells	cell	NNS
cord-001734-bbeznd3r	121	7	.	.	.
cord-001734-bbeznd3r	122	1	The	the	DT
cord-001734-bbeznd3r	122	2	recombinant	recombinant	JJ
cord-001734-bbeznd3r	122	3	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	122	4	protein	protein	NN
cord-001734-bbeznd3r	122	5	was	be	VBD
cord-001734-bbeznd3r	122	6	found	find	VBN
cord-001734-bbeznd3r	122	7	to	to	TO
cord-001734-bbeznd3r	122	8	be	be	VB
cord-001734-bbeznd3r	122	9	completely	completely	RB
cord-001734-bbeznd3r	122	10	insoluble	insoluble	JJ
cord-001734-bbeznd3r	122	11	and	and	CC
cord-001734-bbeznd3r	122	12	all	all	DT
cord-001734-bbeznd3r	122	13	in	in	IN
cord-001734-bbeznd3r	122	14	inclusion	inclusion	NN
cord-001734-bbeznd3r	122	15	body	body	NN
cord-001734-bbeznd3r	122	16	as	as	IN
cord-001734-bbeznd3r	122	17	previously	previously	RB
cord-001734-bbeznd3r	122	18	reported	report	VBD
cord-001734-bbeznd3r	122	19	[	[	-LRB-
cord-001734-bbeznd3r	122	20	7	7	CD
cord-001734-bbeznd3r	122	21	,	,	,
cord-001734-bbeznd3r	122	22	11	11	CD
cord-001734-bbeznd3r	122	23	]	]	-RRB-
cord-001734-bbeznd3r	122	24	.	.	.
cord-001734-bbeznd3r	123	1	As	as	IN
cord-001734-bbeznd3r	123	2	a	a	DT
cord-001734-bbeznd3r	123	3	consequence	consequence	NN
cord-001734-bbeznd3r	123	4	,	,	,
cord-001734-bbeznd3r	123	5	the	the	DT
cord-001734-bbeznd3r	123	6	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	123	7	proteins	protein	NNS
cord-001734-bbeznd3r	123	8	were	be	VBD
cord-001734-bbeznd3r	123	9	first	first	RB
cord-001734-bbeznd3r	123	10	purified	purify	VBN
cord-001734-bbeznd3r	123	11	by	by	IN
cord-001734-bbeznd3r	123	12	Ni	Ni	NNP
cord-001734-bbeznd3r	123	13	2	2	CD
cord-001734-bbeznd3r	124	1	+	+	CC
cord-001734-bbeznd3r	125	1	-affinity	-affinity	:
cord-001734-bbeznd3r	125	2	column	column	NN
cord-001734-bbeznd3r	125	3	under	under	IN
cord-001734-bbeznd3r	125	4	denaturing	denature	VBG
cord-001734-bbeznd3r	125	5	condition	condition	NN
cord-001734-bbeznd3r	125	6	in	in	IN
cord-001734-bbeznd3r	125	7	the	the	DT
cord-001734-bbeznd3r	125	8	presence	presence	NN
cord-001734-bbeznd3r	125	9	of	of	IN
cord-001734-bbeznd3r	125	10	8	8	CD
cord-001734-bbeznd3r	125	11	M	M	NNP
cord-001734-bbeznd3r	125	12	urea	urea	NN
cord-001734-bbeznd3r	125	13	,	,	,
cord-001734-bbeznd3r	125	14	followed	follow	VBN
cord-001734-bbeznd3r	125	15	by	by	IN
cord-001734-bbeznd3r	125	16	purification	purification	NN
cord-001734-bbeznd3r	125	17	with	with	IN
cord-001734-bbeznd3r	125	18	reverse	reverse	JJ
cord-001734-bbeznd3r	125	19	-	-	HYPH
cord-001734-bbeznd3r	125	20	phase	phase	NN
cord-001734-bbeznd3r	125	21	(	(	-LRB-
cord-001734-bbeznd3r	125	22	RP	rp	NN
cord-001734-bbeznd3r	125	23	)	)	-RRB-
cord-001734-bbeznd3r	125	24	HPLC	HPLC	NNP
cord-001734-bbeznd3r	125	25	.	.	.
cord-001734-bbeznd3r	126	1	On	on	IN
cord-001734-bbeznd3r	126	2	the	the	DT
cord-001734-bbeznd3r	126	3	other	other	JJ
cord-001734-bbeznd3r	126	4	hand	hand	NN
cord-001734-bbeznd3r	126	5	,	,	,
cord-001734-bbeznd3r	126	6	the	the	DT
cord-001734-bbeznd3r	126	7	GST	GST	NNP
cord-001734-bbeznd3r	126	8	-	-	HYPH
cord-001734-bbeznd3r	126	9	fused	fuse	VBN
cord-001734-bbeznd3r	126	10	NS2B	NS2B	NNS
cord-001734-bbeznd3r	126	11	(	(	-LRB-
cord-001734-bbeznd3r	126	12	48	48	CD
cord-001734-bbeznd3r	126	13	-	-	SYM
cord-001734-bbeznd3r	126	14	100	100	CD
cord-001734-bbeznd3r	126	15	)	)	-RRB-
cord-001734-bbeznd3r	126	16	cofactor	cofactor	NN
cord-001734-bbeznd3r	126	17	was	be	VBD
cord-001734-bbeznd3r	126	18	found	find	VBN
cord-001734-bbeznd3r	126	19	in	in	IN
cord-001734-bbeznd3r	126	20	supernatant	supernatant	JJ
cord-001734-bbeznd3r	126	21	and	and	CC
cord-001734-bbeznd3r	126	22	thereby	thereby	RB
cord-001734-bbeznd3r	126	23	purified	purify	VBN
cord-001734-bbeznd3r	126	24	under	under	IN
cord-001734-bbeznd3r	126	25	native	native	JJ
cord-001734-bbeznd3r	126	26	condition	condition	NN
cord-001734-bbeznd3r	126	27	,	,	,
cord-001734-bbeznd3r	126	28	followed	follow	VBN
cord-001734-bbeznd3r	126	29	by	by	IN
cord-001734-bbeznd3r	126	30	the	the	DT
cord-001734-bbeznd3r	126	31	thrombin	thrombin	JJ
cord-001734-bbeznd3r	126	32	cleavage	cleavage	NN
cord-001734-bbeznd3r	126	33	to	to	TO
cord-001734-bbeznd3r	126	34	release	release	VB
cord-001734-bbeznd3r	126	35	the	the	DT
cord-001734-bbeznd3r	126	36	cofactor	cofactor	NN
cord-001734-bbeznd3r	126	37	which	which	WDT
cord-001734-bbeznd3r	126	38	was	be	VBD
cord-001734-bbeznd3r	126	39	also	also	RB
cord-001734-bbeznd3r	126	40	purified	purify	VBN
cord-001734-bbeznd3r	126	41	by	by	IN
cord-001734-bbeznd3r	126	42	RP	RP	NNP
cord-001734-bbeznd3r	126	43	-	-	HYPH
cord-001734-bbeznd3r	126	44	HPLC	HPLC	NNP
cord-001734-bbeznd3r	126	45	.	.	.
cord-001734-bbeznd3r	127	1	The	the	DT
cord-001734-bbeznd3r	127	2	lyophilized	lyophilized	JJ
cord-001734-bbeznd3r	127	3	powder	powder	NN
cord-001734-bbeznd3r	127	4	of	of	IN
cord-001734-bbeznd3r	127	5	the	the	DT
cord-001734-bbeznd3r	127	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	127	7	(	(	-LRB-
cord-001734-bbeznd3r	127	8	48	48	CD
cord-001734-bbeznd3r	127	9	-	-	SYM
cord-001734-bbeznd3r	127	10	100	100	CD
cord-001734-bbeznd3r	127	11	)	)	-RRB-
cord-001734-bbeznd3r	127	12	was	be	VBD
cord-001734-bbeznd3r	127	13	soluble	soluble	JJ
cord-001734-bbeznd3r	127	14	both	both	DT
cord-001734-bbeznd3r	127	15	in	in	IN
cord-001734-bbeznd3r	127	16	Mill	Mill	NNP
cord-001734-bbeznd3r	127	17	-	-	HYPH
cord-001734-bbeznd3r	127	18	Q	Q	NNP
cord-001734-bbeznd3r	127	19	water	water	NN
cord-001734-bbeznd3r	127	20	and	and	CC
cord-001734-bbeznd3r	127	21	in	in	IN
cord-001734-bbeznd3r	127	22	buffers	buffer	NNS
cord-001734-bbeznd3r	127	23	,	,	,
cord-001734-bbeznd3r	127	24	while	while	IN
cord-001734-bbeznd3r	127	25	the	the	DT
cord-001734-bbeznd3r	127	26	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	127	27	protein	protein	NN
cord-001734-bbeznd3r	127	28	was	be	VBD
cord-001734-bbeznd3r	127	29	highly	highly	RB
cord-001734-bbeznd3r	127	30	soluble	soluble	JJ
cord-001734-bbeznd3r	127	31	at	at	IN
cord-001734-bbeznd3r	127	32	protein	protein	NN
cord-001734-bbeznd3r	127	33	concentration	concentration	NN
cord-001734-bbeznd3r	127	34	of	of	IN
cord-001734-bbeznd3r	127	35	1	1	CD
cord-001734-bbeznd3r	127	36	mM	mm	CD
cord-001734-bbeznd3r	127	37	without	without	IN
cord-001734-bbeznd3r	127	38	any	any	DT
cord-001734-bbeznd3r	127	39	detectable	detectable	JJ
cord-001734-bbeznd3r	127	40	aggregation	aggregation	NN
cord-001734-bbeznd3r	127	41	for	for	IN
cord-001734-bbeznd3r	127	42	at	at	RB
cord-001734-bbeznd3r	127	43	least	least	JJS
cord-001734-bbeznd3r	127	44	half	half	PDT
cord-001734-bbeznd3r	127	45	a	a	DT
cord-001734-bbeznd3r	127	46	year	year	NN
cord-001734-bbeznd3r	127	47	in	in	IN
cord-001734-bbeznd3r	127	48	Mill	Mill	NNP
cord-001734-bbeznd3r	127	49	-	-	HYPH
cord-001734-bbeznd3r	127	50	Q	Q	NNP
cord-001734-bbeznd3r	127	51	water	water	NN
cord-001734-bbeznd3r	127	52	.	.	.
cord-001734-bbeznd3r	128	1	The	the	DT
cord-001734-bbeznd3r	128	2	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	128	3	protein	protein	NN
cord-001734-bbeznd3r	128	4	also	also	RB
cord-001734-bbeznd3r	128	5	could	could	MD
cord-001734-bbeznd3r	128	6	be	be	VB
cord-001734-bbeznd3r	128	7	quickly	quickly	RB
cord-001734-bbeznd3r	128	8	diluted	dilute	VBN
cord-001734-bbeznd3r	128	9	into	into	IN
cord-001734-bbeznd3r	128	10	5	5	CD
cord-001734-bbeznd3r	128	11	mM	mm	CD
cord-001734-bbeznd3r	128	12	phosphate	phosphate	NN
cord-001734-bbeznd3r	128	13	buffer	buffer	NN
cord-001734-bbeznd3r	128	14	with	with	IN
cord-001734-bbeznd3r	128	15	a	a	DT
cord-001734-bbeznd3r	128	16	final	final	JJ
cord-001734-bbeznd3r	128	17	protein	protein	NN
cord-001734-bbeznd3r	128	18	concentration	concentration	NN
cord-001734-bbeznd3r	128	19	of	of	IN
cord-001734-bbeznd3r	128	20	100	100	CD
cord-001734-bbeznd3r	128	21	μM	μm	NN
cord-001734-bbeznd3r	128	22	and	and	CC
cord-001734-bbeznd3r	128	23	pH	ph	NN
cord-001734-bbeznd3r	128	24	of	of	IN
cord-001734-bbeznd3r	128	25	7.0	7.0	CD
cord-001734-bbeznd3r	128	26	without	without	IN
cord-001734-bbeznd3r	128	27	visible	visible	JJ
cord-001734-bbeznd3r	128	28	aggregates	aggregate	NNS
cord-001734-bbeznd3r	128	29	for	for	IN
cord-001734-bbeznd3r	128	30	1	1	CD
cord-001734-bbeznd3r	128	31	hr	hr	NN
cord-001734-bbeznd3r	128	32	,	,	,
cord-001734-bbeznd3r	128	33	but	but	CC
cord-001734-bbeznd3r	128	34	formed	form	VBD
cord-001734-bbeznd3r	128	35	aggregates	aggregate	NNS
cord-001734-bbeznd3r	128	36	in	in	IN
cord-001734-bbeznd3r	128	37	NMR	NMR	NNP
cord-001734-bbeznd3r	128	38	tube	tube	NN
cord-001734-bbeznd3r	128	39	after	after	IN
cord-001734-bbeznd3r	128	40	4	4	CD
cord-001734-bbeznd3r	128	41	hr	hr	NN
cord-001734-bbeznd3r	128	42	,	,	,
cord-001734-bbeznd3r	128	43	which	which	WDT
cord-001734-bbeznd3r	128	44	has	have	VBZ
cord-001734-bbeznd3r	128	45	been	be	VBN
cord-001734-bbeznd3r	128	46	commonly	commonly	RB
cord-001734-bbeznd3r	128	47	observed	observe	VBN
cord-001734-bbeznd3r	128	48	on	on	IN
cord-001734-bbeznd3r	128	49	a	a	DT
cord-001734-bbeznd3r	128	50	variety	variety	NN
cord-001734-bbeznd3r	128	51	of	of	IN
cord-001734-bbeznd3r	128	52	"	"	``
cord-001734-bbeznd3r	128	53	completely	completely	RB
cord-001734-bbeznd3r	128	54	insoluble	insoluble	JJ
cord-001734-bbeznd3r	128	55	"	"	''
cord-001734-bbeznd3r	128	56	proteins	protein	NNS
cord-001734-bbeznd3r	128	57	previously	previously	RB
cord-001734-bbeznd3r	128	58	reported	report	VBN
cord-001734-bbeznd3r	128	59	by	by	IN
cord-001734-bbeznd3r	128	60	us	-PRON-	PRP
cord-001734-bbeznd3r	128	61	and	and	CC
cord-001734-bbeznd3r	128	62	other	other	JJ
cord-001734-bbeznd3r	128	63	groups	group	NNS
cord-001734-bbeznd3r	128	64	[	[	-LRB-
cord-001734-bbeznd3r	128	65	15	15	CD
cord-001734-bbeznd3r	128	66	]	]	-RRB-
cord-001734-bbeznd3r	128	67	[	[	-LRB-
cord-001734-bbeznd3r	128	68	16	16	CD
cord-001734-bbeznd3r	128	69	]	]	-RRB-
cord-001734-bbeznd3r	128	70	[	[	-LRB-
cord-001734-bbeznd3r	128	71	17	17	CD
cord-001734-bbeznd3r	128	72	]	]	-RRB-
cord-001734-bbeznd3r	128	73	[	[	-LRB-
cord-001734-bbeznd3r	128	74	18	18	CD
cord-001734-bbeznd3r	128	75	]	]	-RRB-
cord-001734-bbeznd3r	128	76	.	.	.
cord-001734-bbeznd3r	129	1	As	as	IN
cord-001734-bbeznd3r	129	2	shown	show	VBN
cord-001734-bbeznd3r	129	3	in	in	IN
cord-001734-bbeznd3r	129	4	Fig	Fig	NNP
cord-001734-bbeznd3r	129	5	1A	1a	NN
cord-001734-bbeznd3r	129	6	,	,	,
cord-001734-bbeznd3r	129	7	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	129	8	has	have	VBZ
cord-001734-bbeznd3r	129	9	very	very	RB
cord-001734-bbeznd3r	129	10	similar	similar	JJ
cord-001734-bbeznd3r	129	11	far	far	JJ
cord-001734-bbeznd3r	129	12	-	-	HYPH
cord-001734-bbeznd3r	129	13	UV	uv	NN
cord-001734-bbeznd3r	129	14	CD	cd	NN
cord-001734-bbeznd3r	129	15	spectra	spectrum	NNS
cord-001734-bbeznd3r	129	16	in	in	IN
cord-001734-bbeznd3r	129	17	Milli	Milli	NNP
cord-001734-bbeznd3r	129	18	-	-	HYPH
cord-001734-bbeznd3r	129	19	Q	Q	NNP
cord-001734-bbeznd3r	129	20	water	water	NN
cord-001734-bbeznd3r	129	21	(	(	-LRB-
cord-001734-bbeznd3r	130	1	pH	pH	NNP
cord-001734-bbeznd3r	130	2	4.0	4.0	CD
cord-001734-bbeznd3r	130	3	)	)	-RRB-
cord-001734-bbeznd3r	130	4	and	and	CC
cord-001734-bbeznd3r	130	5	5	5	CD
cord-001734-bbeznd3r	130	6	mM	mm	CD
cord-001734-bbeznd3r	130	7	phosphate	phosphate	NN
cord-001734-bbeznd3r	130	8	buffer	buffer	NN
cord-001734-bbeznd3r	130	9	(	(	-LRB-
cord-001734-bbeznd3r	130	10	pH	pH	NNP
cord-001734-bbeznd3r	130	11	7.0	7.0	CD
cord-001734-bbeznd3r	130	12	)	)	-RRB-
cord-001734-bbeznd3r	130	13	,	,	,
cord-001734-bbeznd3r	130	14	with	with	IN
cord-001734-bbeznd3r	130	15	the	the	DT
cord-001734-bbeznd3r	130	16	maximal	maximal	JJ
cord-001734-bbeznd3r	130	17	negative	negative	JJ
cord-001734-bbeznd3r	130	18	signal	signal	NN
cord-001734-bbeznd3r	130	19	at	at	IN
cord-001734-bbeznd3r	130	20	200	200	CD
cord-001734-bbeznd3r	130	21	nm	nm	NN
cord-001734-bbeznd3r	130	22	and	and	CC
cord-001734-bbeznd3r	130	23	no	no	DT
cord-001734-bbeznd3r	130	24	positive	positive	JJ
cord-001734-bbeznd3r	130	25	signal	signal	NN
cord-001734-bbeznd3r	130	26	below	below	IN
cord-001734-bbeznd3r	130	27	200	200	CD
cord-001734-bbeznd3r	130	28	nm	nm	NN
cord-001734-bbeznd3r	130	29	,	,	,
cord-001734-bbeznd3r	130	30	which	which	WDT
cord-001734-bbeznd3r	130	31	is	be	VBZ
cord-001734-bbeznd3r	130	32	typical	typical	JJ
cord-001734-bbeznd3r	130	33	of	of	IN
cord-001734-bbeznd3r	130	34	a	a	DT
cord-001734-bbeznd3r	130	35	predominantly	predominantly	RB
cord-001734-bbeznd3r	130	36	disordered	disordered	JJ
cord-001734-bbeznd3r	130	37	protein	protein	NN
cord-001734-bbeznd3r	130	38	without	without	IN
cord-001734-bbeznd3r	130	39	any	any	DT
cord-001734-bbeznd3r	130	40	stable	stable	JJ
cord-001734-bbeznd3r	130	41	secondary	secondary	JJ
cord-001734-bbeznd3r	130	42	structure	structure	NN
cord-001734-bbeznd3r	130	43	.	.	.
cord-001734-bbeznd3r	131	1	This	this	DT
cord-001734-bbeznd3r	131	2	indicates	indicate	VBZ
cord-001734-bbeznd3r	131	3	that	that	IN
cord-001734-bbeznd3r	131	4	the	the	DT
cord-001734-bbeznd3r	131	5	isolated	isolated	JJ
cord-001734-bbeznd3r	131	6	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	131	7	domain	domain	NN
cord-001734-bbeznd3r	131	8	is	be	VBZ
cord-001734-bbeznd3r	131	9	highly	highly	RB
cord-001734-bbeznd3r	131	10	disordered	disordered	JJ
cord-001734-bbeznd3r	131	11	in	in	IN
cord-001734-bbeznd3r	131	12	aqueous	aqueous	JJ
cord-001734-bbeznd3r	131	13	solution	solution	NN
cord-001734-bbeznd3r	131	14	.	.	.
cord-001734-bbeznd3r	132	1	Indeed	indeed	RB
cord-001734-bbeznd3r	132	2	,	,	,
cord-001734-bbeznd3r	132	3	the	the	DT
cord-001734-bbeznd3r	132	4	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	132	5	of	of	IN
cord-001734-bbeznd3r	132	6	its	-PRON-	PRP$
cord-001734-bbeznd3r	132	7	CD	cd	NN
cord-001734-bbeznd3r	132	8	spectrum	spectrum	NN
cord-001734-bbeznd3r	132	9	reveals	reveal	VBZ
cord-001734-bbeznd3r	132	10	that	that	IN
cord-001734-bbeznd3r	132	11	the	the	DT
cord-001734-bbeznd3r	132	12	isolated	isolated	JJ
cord-001734-bbeznd3r	132	13	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	132	14	consists	consist	VBZ
cord-001734-bbeznd3r	132	15	of	of	IN
cord-001734-bbeznd3r	132	16	53	53	CD
cord-001734-bbeznd3r	132	17	%	%	NN
cord-001734-bbeznd3r	132	18	random	random	JJ
cord-001734-bbeznd3r	132	19	coil	coil	NN
cord-001734-bbeznd3r	132	20	,	,	,
cord-001734-bbeznd3r	132	21	14	14	CD
cord-001734-bbeznd3r	132	22	%	%	NN
cord-001734-bbeznd3r	132	23	turn	turn	NN
cord-001734-bbeznd3r	132	24	,	,	,
cord-001734-bbeznd3r	132	25	29	29	CD
cord-001734-bbeznd3r	132	26	%	%	NN
cord-001734-bbeznd3r	132	27	extended	extended	JJ
cord-001734-bbeznd3r	132	28	strand	strand	NN
cord-001734-bbeznd3r	132	29	and	and	CC
cord-001734-bbeznd3r	132	30	4	4	CD
cord-001734-bbeznd3r	132	31	%	%	NN
cord-001734-bbeznd3r	132	32	helix	helix	NN
cord-001734-bbeznd3r	132	33	secondary	secondary	JJ
cord-001734-bbeznd3r	132	34	structures	structure	NNS
cord-001734-bbeznd3r	132	35	.	.	.
cord-001734-bbeznd3r	133	1	Moreover	moreover	RB
cord-001734-bbeznd3r	133	2	,	,	,
cord-001734-bbeznd3r	133	3	it	-PRON-	PRP
cord-001734-bbeznd3r	133	4	has	have	VBZ
cord-001734-bbeznd3r	133	5	a	a	DT
cord-001734-bbeznd3r	133	6	HSQC	HSQC	NNP
cord-001734-bbeznd3r	133	7	spectrum	spectrum	NN
cord-001734-bbeznd3r	133	8	with	with	IN
cord-001734-bbeznd3r	133	9	very	very	RB
cord-001734-bbeznd3r	133	10	narrow	narrow	JJ
cord-001734-bbeznd3r	133	11	spectral	spectral	JJ
cord-001734-bbeznd3r	133	12	dispersions	dispersion	NNS
cord-001734-bbeznd3r	133	13	at	at	IN
cord-001734-bbeznd3r	133	14	both	both	DT
cord-001734-bbeznd3r	133	15	1	1	CD
cord-001734-bbeznd3r	133	16	H	h	NN
cord-001734-bbeznd3r	133	17	(	(	-LRB-
cord-001734-bbeznd3r	133	18	~0.9	~0.9	CD
cord-001734-bbeznd3r	133	19	ppm	ppm	NN
cord-001734-bbeznd3r	133	20	)	)	-RRB-
cord-001734-bbeznd3r	133	21	and	and	CC
cord-001734-bbeznd3r	133	22	15	15	CD
cord-001734-bbeznd3r	133	23	N	n	CD
cord-001734-bbeznd3r	133	24	(	(	-LRB-
cord-001734-bbeznd3r	133	25	~19	~19	NFP
cord-001734-bbeznd3r	133	26	ppm	ppm	NN
cord-001734-bbeznd3r	133	27	)	)	-RRB-
cord-001734-bbeznd3r	133	28	dimensions	dimension	NNS
cord-001734-bbeznd3r	133	29	(	(	-LRB-
cord-001734-bbeznd3r	133	30	Fig	Fig	NNP
cord-001734-bbeznd3r	133	31	1B	1b	NN
cord-001734-bbeznd3r	133	32	)	)	-RRB-
cord-001734-bbeznd3r	133	33	,	,	,
cord-001734-bbeznd3r	133	34	further	further	RB
cord-001734-bbeznd3r	133	35	indicating	indicate	VBG
cord-001734-bbeznd3r	133	36	the	the	DT
cord-001734-bbeznd3r	133	37	absence	absence	NN
cord-001734-bbeznd3r	133	38	of	of	IN
cord-001734-bbeznd3r	133	39	tight	tight	JJ
cord-001734-bbeznd3r	133	40	tertiary	tertiary	JJ
cord-001734-bbeznd3r	133	41	packing	packing	NN
cord-001734-bbeznd3r	133	42	.	.	.
cord-001734-bbeznd3r	134	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	134	2	,	,	,
cord-001734-bbeznd3r	134	3	on	on	IN
cord-001734-bbeznd3r	134	4	the	the	DT
cord-001734-bbeznd3r	134	5	other	other	JJ
cord-001734-bbeznd3r	134	6	hand	hand	NN
cord-001734-bbeznd3r	134	7	,	,	,
cord-001734-bbeznd3r	134	8	NS2B	NS2B	NNP
cord-001734-bbeznd3r	134	9	(	(	-LRB-
cord-001734-bbeznd3r	134	10	48	48	CD
cord-001734-bbeznd3r	134	11	-	-	SYM
cord-001734-bbeznd3r	134	12	100	100	CD
cord-001734-bbeznd3r	134	13	)	)	-RRB-
cord-001734-bbeznd3r	134	14	has	have	VBZ
cord-001734-bbeznd3r	134	15	a	a	DT
cord-001734-bbeznd3r	134	16	CD	cd	NN
cord-001734-bbeznd3r	134	17	spectrum	spectrum	NN
cord-001734-bbeznd3r	134	18	with	with	IN
cord-001734-bbeznd3r	134	19	the	the	DT
cord-001734-bbeznd3r	134	20	maximal	maximal	JJ
cord-001734-bbeznd3r	134	21	negative	negative	JJ
cord-001734-bbeznd3r	134	22	signal	signal	NN
cord-001734-bbeznd3r	134	23	at	at	IN
cord-001734-bbeznd3r	134	24	206	206	CD
cord-001734-bbeznd3r	134	25	nm	nm	NN
cord-001734-bbeznd3r	134	26	and	and	CC
cord-001734-bbeznd3r	134	27	positive	positive	JJ
cord-001734-bbeznd3r	134	28	signal	signal	NN
cord-001734-bbeznd3r	134	29	at	at	IN
cord-001734-bbeznd3r	134	30	190	190	CD
cord-001734-bbeznd3r	134	31	nm	nm	NN
cord-001734-bbeznd3r	134	32	,	,	,
cord-001734-bbeznd3r	134	33	as	as	RB
cord-001734-bbeznd3r	134	34	well	well	RB
cord-001734-bbeznd3r	134	35	as	as	IN
cord-001734-bbeznd3r	134	36	an	an	DT
cord-001734-bbeznd3r	134	37	additional	additional	JJ
cord-001734-bbeznd3r	134	38	negative	negative	JJ
cord-001734-bbeznd3r	134	39	signal	signal	NN
cord-001734-bbeznd3r	134	40	at	at	IN
cord-001734-bbeznd3r	134	41	222	222	CD
cord-001734-bbeznd3r	134	42	nm	nm	NN
cord-001734-bbeznd3r	134	43	.	.	.
cord-001734-bbeznd3r	135	1	Further	further	JJ
cord-001734-bbeznd3r	135	2	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	135	3	shows	show	VBZ
cord-001734-bbeznd3r	135	4	that	that	IN
cord-001734-bbeznd3r	135	5	it	-PRON-	PRP
cord-001734-bbeznd3r	135	6	contains	contain	VBZ
cord-001734-bbeznd3r	135	7	32	32	CD
cord-001734-bbeznd3r	135	8	%	%	NN
cord-001734-bbeznd3r	135	9	random	random	JJ
cord-001734-bbeznd3r	135	10	coil	coil	NN
cord-001734-bbeznd3r	135	11	,	,	,
cord-001734-bbeznd3r	135	12	24	24	CD
cord-001734-bbeznd3r	135	13	%	%	NN
cord-001734-bbeznd3r	135	14	turn	turn	NN
cord-001734-bbeznd3r	135	15	,	,	,
cord-001734-bbeznd3r	135	16	7	7	CD
cord-001734-bbeznd3r	135	17	%	%	NN
cord-001734-bbeznd3r	135	18	extended	extended	JJ
cord-001734-bbeznd3r	135	19	strand	strand	NN
cord-001734-bbeznd3r	135	20	and	and	CC
cord-001734-bbeznd3r	135	21	37	37	CD
cord-001734-bbeznd3r	135	22	%	%	NN
cord-001734-bbeznd3r	135	23	helix	helix	NN
cord-001734-bbeznd3r	135	24	secondary	secondary	JJ
cord-001734-bbeznd3r	135	25	structures	structure	NNS
cord-001734-bbeznd3r	135	26	.	.	.
cord-001734-bbeznd3r	136	1	Previously	Previously	NNP
cord-001734-bbeznd3r	136	2	NS2B	NS2B	NNP
cord-001734-bbeznd3r	136	3	has	have	VBZ
cord-001734-bbeznd3r	136	4	been	be	VBN
cord-001734-bbeznd3r	136	5	shown	show	VBN
cord-001734-bbeznd3r	136	6	to	to	TO
cord-001734-bbeznd3r	136	7	have	have	VB
cord-001734-bbeznd3r	136	8	slightly	slightly	RB
cord-001734-bbeznd3r	136	9	different	different	JJ
cord-001734-bbeznd3r	136	10	secondary	secondary	JJ
cord-001734-bbeznd3r	136	11	structures	structure	NNS
cord-001734-bbeznd3r	136	12	in	in	IN
cord-001734-bbeznd3r	136	13	the	the	DT
cord-001734-bbeznd3r	136	14	open	open	JJ
cord-001734-bbeznd3r	136	15	[	[	-LRB-
cord-001734-bbeznd3r	136	16	7	7	CD
cord-001734-bbeznd3r	136	17	]	]	-RRB-
cord-001734-bbeznd3r	136	18	and	and	CC
cord-001734-bbeznd3r	136	19	closed	close	VBD
cord-001734-bbeznd3r	136	20	[	[	-LRB-
cord-001734-bbeznd3r	136	21	8	8	CD
cord-001734-bbeznd3r	136	22	]	]	-RRB-
cord-001734-bbeznd3r	136	23	states	state	NNS
cord-001734-bbeznd3r	136	24	of	of	IN
cord-001734-bbeznd3r	136	25	the	the	DT
cord-001734-bbeznd3r	136	26	NS2B	NS2B	NNP
cord-001734-bbeznd3r	136	27	-	-	HYPH
cord-001734-bbeznd3r	136	28	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	136	29	complexes	complex	NNS
cord-001734-bbeznd3r	136	30	.	.	.
cord-001734-bbeznd3r	137	1	In	in	IN
cord-001734-bbeznd3r	137	2	the	the	DT
cord-001734-bbeznd3r	137	3	open	open	JJ
cord-001734-bbeznd3r	137	4	(	(	-LRB-
cord-001734-bbeznd3r	137	5	inactive	inactive	JJ
cord-001734-bbeznd3r	137	6	)	)	-RRB-
cord-001734-bbeznd3r	137	7	state	state	NN
cord-001734-bbeznd3r	137	8	(	(	-LRB-
cord-001734-bbeznd3r	137	9	PDB	PDB	NNP
cord-001734-bbeznd3r	137	10	ID	ID	NNP
cord-001734-bbeznd3r	137	11	:	:	:
cord-001734-bbeznd3r	137	12	2FOM	2fom	LS
cord-001734-bbeznd3r	137	13	)	)	-RRB-
cord-001734-bbeznd3r	137	14	,	,	,
cord-001734-bbeznd3r	137	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	137	16	has	have	VBZ
cord-001734-bbeznd3r	137	17	a	a	DT
cord-001734-bbeznd3r	137	18	short	short	JJ
cord-001734-bbeznd3r	137	19	helix	helix	NN
cord-001734-bbeznd3r	137	20	over	over	IN
cord-001734-bbeznd3r	137	21	residues	residue	NNS
cord-001734-bbeznd3r	137	22	Glu62-Gly69	glu62-gly69	VBP
cord-001734-bbeznd3r	137	23	while	while	IN
cord-001734-bbeznd3r	137	24	in	in	IN
cord-001734-bbeznd3r	137	25	the	the	DT
cord-001734-bbeznd3r	137	26	closed	closed	JJ
cord-001734-bbeznd3r	137	27	(	(	-LRB-
cord-001734-bbeznd3r	137	28	active	active	JJ
cord-001734-bbeznd3r	137	29	)	)	-RRB-
cord-001734-bbeznd3r	137	30	state	state	NN
cord-001734-bbeznd3r	137	31	(	(	-LRB-
cord-001734-bbeznd3r	137	32	PDB	PDB	NNP
cord-001734-bbeznd3r	137	33	ID	ID	NNP
cord-001734-bbeznd3r	137	34	:	:	:
cord-001734-bbeznd3r	137	35	3U1I	3u1i	CD
cord-001734-bbeznd3r	137	36	)	)	-RRB-
cord-001734-bbeznd3r	137	37	,	,	,
cord-001734-bbeznd3r	137	38	the	the	DT
cord-001734-bbeznd3r	137	39	NS2B	NS2B	NNP
cord-001734-bbeznd3r	137	40	only	only	RB
cord-001734-bbeznd3r	137	41	has	have	VBZ
cord-001734-bbeznd3r	137	42	β	β	NN
cord-001734-bbeznd3r	137	43	-	-	HYPH
cord-001734-bbeznd3r	137	44	strands	strand	NNS
cord-001734-bbeznd3r	137	45	but	but	CC
cord-001734-bbeznd3r	137	46	no	no	DT
cord-001734-bbeznd3r	137	47	helical	helical	JJ
cord-001734-bbeznd3r	137	48	segment	segment	NN
cord-001734-bbeznd3r	137	49	.	.	.
cord-001734-bbeznd3r	138	1	Therefore	therefore	RB
cord-001734-bbeznd3r	138	2	,	,	,
cord-001734-bbeznd3r	138	3	it	-PRON-	PRP
cord-001734-bbeznd3r	138	4	is	be	VBZ
cord-001734-bbeznd3r	138	5	possible	possible	JJ
cord-001734-bbeznd3r	138	6	that	that	IN
cord-001734-bbeznd3r	138	7	upon	upon	IN
cord-001734-bbeznd3r	138	8	losing	lose	VBG
cord-001734-bbeznd3r	138	9	tertiary	tertiary	JJ
cord-001734-bbeznd3r	138	10	contacts	contact	NNS
cord-001734-bbeznd3r	138	11	with	with	IN
cord-001734-bbeznd3r	138	12	the	the	DT
cord-001734-bbeznd3r	138	13	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	138	14	domain	domain	NN
cord-001734-bbeznd3r	138	15	,	,	,
cord-001734-bbeznd3r	138	16	the	the	DT
cord-001734-bbeznd3r	138	17	free	free	JJ
cord-001734-bbeznd3r	138	18	-	-	HYPH
cord-001734-bbeznd3r	138	19	state	state	NN
cord-001734-bbeznd3r	138	20	NS2B	NS2B	NNP
cord-001734-bbeznd3r	138	21	has	have	VBZ
cord-001734-bbeznd3r	138	22	more	more	RBR
cord-001734-bbeznd3r	138	23	helical	helical	JJ
cord-001734-bbeznd3r	138	24	conformations	conformation	NNS
cord-001734-bbeznd3r	138	25	populated	populate	VBN
cord-001734-bbeznd3r	138	26	over	over	IN
cord-001734-bbeznd3r	138	27	residues	residue	NNS
cord-001734-bbeznd3r	138	28	Glu62-Gly69	glu62-gly69	RB
cord-001734-bbeznd3r	138	29	,	,	,
cord-001734-bbeznd3r	138	30	or	or	CC
cord-001734-bbeznd3r	138	31	/	/	SYM
cord-001734-bbeznd3r	138	32	and	and	CC
cord-001734-bbeznd3r	138	33	even	even	RB
cord-001734-bbeznd3r	138	34	has	have	VBZ
cord-001734-bbeznd3r	138	35	helical	helical	JJ
cord-001734-bbeznd3r	138	36	conformations	conformation	NNS
cord-001734-bbeznd3r	138	37	populated	populate	VBN
cord-001734-bbeznd3r	138	38	over	over	IN
cord-001734-bbeznd3r	138	39	residues	residue	NNS
cord-001734-bbeznd3r	138	40	which	which	WDT
cord-001734-bbeznd3r	138	41	adopt	adopt	VBP
cord-001734-bbeznd3r	138	42	βstrands	βstrand	NNS
cord-001734-bbeznd3r	138	43	in	in	IN
cord-001734-bbeznd3r	138	44	the	the	DT
cord-001734-bbeznd3r	138	45	NS2B	NS2B	NNP
cord-001734-bbeznd3r	138	46	-	-	HYPH
cord-001734-bbeznd3r	138	47	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	138	48	complexes	complex	NNS
cord-001734-bbeznd3r	138	49	.	.	.
cord-001734-bbeznd3r	139	1	Indeed	indeed	RB
cord-001734-bbeznd3r	139	2	,	,	,
cord-001734-bbeznd3r	139	3	we	-PRON-	PRP
cord-001734-bbeznd3r	139	4	previously	previously	RB
cord-001734-bbeznd3r	139	5	observed	observe	VBD
cord-001734-bbeznd3r	139	6	that	that	IN
cord-001734-bbeznd3r	139	7	upon	upon	IN
cord-001734-bbeznd3r	139	8	disrupting	disrupt	VBG
cord-001734-bbeznd3r	139	9	the	the	DT
cord-001734-bbeznd3r	139	10	all	all	DT
cord-001734-bbeznd3r	139	11	β	β	NN
cord-001734-bbeznd3r	139	12	-	-	HYPH
cord-001734-bbeznd3r	139	13	barrel	barrel	NN
cord-001734-bbeznd3r	139	14	native	native	JJ
cord-001734-bbeznd3r	139	15	fold	fold	NN
cord-001734-bbeznd3r	139	16	,	,	,
cord-001734-bbeznd3r	139	17	the	the	DT
cord-001734-bbeznd3r	139	18	mutants	mutant	NNS
cord-001734-bbeznd3r	139	19	of	of	IN
cord-001734-bbeznd3r	139	20	a	a	DT
cord-001734-bbeznd3r	139	21	SH3	SH3	NNP
cord-001734-bbeznd3r	139	22	domain	domain	NN
cord-001734-bbeznd3r	139	23	became	become	VBD
cord-001734-bbeznd3r	139	24	highly	highly	RB
cord-001734-bbeznd3r	139	25	helical	helical	JJ
cord-001734-bbeznd3r	139	26	even	even	RB
cord-001734-bbeznd3r	139	27	over	over	IN
cord-001734-bbeznd3r	139	28	the	the	DT
cord-001734-bbeznd3r	139	29	residues	residue	NNS
cord-001734-bbeznd3r	139	30	which	which	WDT
cord-001734-bbeznd3r	139	31	adopt	adopt	VBP
cord-001734-bbeznd3r	139	32	β	β	NN
cord-001734-bbeznd3r	139	33	-	-	HYPH
cord-001734-bbeznd3r	139	34	strands	strand	NNS
cord-001734-bbeznd3r	139	35	in	in	IN
cord-001734-bbeznd3r	139	36	the	the	DT
cord-001734-bbeznd3r	139	37	native	native	JJ
cord-001734-bbeznd3r	139	38	fold	fold	NN
cord-001734-bbeznd3r	139	39	[	[	-LRB-
cord-001734-bbeznd3r	139	40	31	31	CD
cord-001734-bbeznd3r	139	41	]	]	-RRB-
cord-001734-bbeznd3r	139	42	.	.	.
cord-001734-bbeznd3r	140	1	Unfortunately	unfortunately	RB
cord-001734-bbeznd3r	140	2	,	,	,
cord-001734-bbeznd3r	140	3	HSQC	HSQC	NNP
cord-001734-bbeznd3r	140	4	peaks	peak	NNS
cord-001734-bbeznd3r	140	5	of	of	IN
cord-001734-bbeznd3r	140	6	the	the	DT
cord-001734-bbeznd3r	140	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	140	8	(	(	-LRB-
cord-001734-bbeznd3r	140	9	48	48	CD
cord-001734-bbeznd3r	140	10	-	-	SYM
cord-001734-bbeznd3r	140	11	100	100	CD
cord-001734-bbeznd3r	140	12	)	)	-RRB-
cord-001734-bbeznd3r	140	13	are	be	VBP
cord-001734-bbeznd3r	140	14	much	much	RB
cord-001734-bbeznd3r	140	15	more	more	RBR
cord-001734-bbeznd3r	140	16	broadened	broaden	VBN
cord-001734-bbeznd3r	140	17	than	than	IN
cord-001734-bbeznd3r	140	18	those	those	DT
cord-001734-bbeznd3r	140	19	of	of	IN
cord-001734-bbeznd3r	140	20	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	140	21	,	,	,
cord-001734-bbeznd3r	140	22	implying	imply	VBG
cord-001734-bbeznd3r	140	23	that	that	IN
cord-001734-bbeznd3r	140	24	the	the	DT
cord-001734-bbeznd3r	140	25	isolated	isolate	VBN
cord-001734-bbeznd3r	140	26	NS2B	NS2B	NNS
cord-001734-bbeznd3r	140	27	(	(	-LRB-
cord-001734-bbeznd3r	140	28	48	48	CD
cord-001734-bbeznd3r	140	29	-	-	SYM
cord-001734-bbeznd3r	140	30	100	100	CD
cord-001734-bbeznd3r	140	31	)	)	-RRB-
cord-001734-bbeznd3r	140	32	has	have	VBZ
cord-001734-bbeznd3r	140	33	dynamic	dynamic	JJ
cord-001734-bbeznd3r	140	34	aggregation	aggregation	NN
cord-001734-bbeznd3r	140	35	or	or	CC
cord-001734-bbeznd3r	140	36	/	/	SYM
cord-001734-bbeznd3r	140	37	and	and	CC
cord-001734-bbeznd3r	140	38	conformational	conformational	JJ
cord-001734-bbeznd3r	140	39	exchanges	exchange	NNS
cord-001734-bbeznd3r	140	40	on	on	IN
cord-001734-bbeznd3r	140	41	the	the	DT
cord-001734-bbeznd3r	140	42	μs	μs	NNP
cord-001734-bbeznd3r	140	43	-	-	HYPH
cord-001734-bbeznd3r	140	44	ms	ms	NNP
cord-001734-bbeznd3r	140	45	time	time	NN
cord-001734-bbeznd3r	140	46	scale	scale	NN
cord-001734-bbeznd3r	140	47	,	,	,
cord-001734-bbeznd3r	140	48	thus	thus	RB
cord-001734-bbeznd3r	140	49	preventing	prevent	VBG
cord-001734-bbeznd3r	140	50	from	from	IN
cord-001734-bbeznd3r	140	51	further	further	JJ
cord-001734-bbeznd3r	140	52	high	high	JJ
cord-001734-bbeznd3r	140	53	-	-	HYPH
cord-001734-bbeznd3r	140	54	resolution	resolution	NN
cord-001734-bbeznd3r	140	55	NMR	NMR	NNP
cord-001734-bbeznd3r	140	56	studies	study	NNS
cord-001734-bbeznd3r	140	57	.	.	.
cord-001734-bbeznd3r	141	1	Despite	despite	IN
cord-001734-bbeznd3r	141	2	its	-PRON-	PRP$
cord-001734-bbeznd3r	141	3	narrow	narrow	JJ
cord-001734-bbeznd3r	141	4	spectral	spectral	JJ
cord-001734-bbeznd3r	141	5	dispersions	dispersion	NNS
cord-001734-bbeznd3r	141	6	,	,	,
cord-001734-bbeznd3r	141	7	we	-PRON-	PRP
cord-001734-bbeznd3r	141	8	have	have	VBP
cord-001734-bbeznd3r	141	9	successfully	successfully	RB
cord-001734-bbeznd3r	141	10	assigned	assign	VBN
cord-001734-bbeznd3r	141	11	NMR	NMR	NNP
cord-001734-bbeznd3r	141	12	resonances	resonance	NNS
cord-001734-bbeznd3r	141	13	of	of	IN
cord-001734-bbeznd3r	141	14	almost	almost	RB
cord-001734-bbeznd3r	141	15	all	all	DT
cord-001734-bbeznd3r	141	16	non	non	JJ
cord-001734-bbeznd3r	141	17	-	-	JJ
cord-001734-bbeznd3r	141	18	proline	proline	JJ
cord-001734-bbeznd3r	141	19	residues	residue	NNS
cord-001734-bbeznd3r	141	20	of	of	IN
cord-001734-bbeznd3r	141	21	the	the	DT
cord-001734-bbeznd3r	141	22	172-residue	172-residue	CD
cord-001734-bbeznd3r	141	23	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	141	24	(	(	-LRB-
cord-001734-bbeznd3r	141	25	14	14	CD
cord-001734-bbeznd3r	141	26	-	-	SYM
cord-001734-bbeznd3r	141	27	185	185	CD
cord-001734-bbeznd3r	141	28	)	)	-RRB-
cord-001734-bbeznd3r	141	29	by	by	IN
cord-001734-bbeznd3r	141	30	analyzing	analyze	VBG
cord-001734-bbeznd3r	141	31	NMR	NMR	NNP
cord-001734-bbeznd3r	141	32	spectra	spectrum	NNS
cord-001734-bbeznd3r	141	33	including	include	VBG
cord-001734-bbeznd3r	141	34	HN(CO)CACB	HN(CO)CACB	NNP
cord-001734-bbeznd3r	141	35	/	/	SYM
cord-001734-bbeznd3r	141	36	CBCA(CO)HN	CBCA(CO)HN	NNP
cord-001734-bbeznd3r	141	37	and	and	CC
cord-001734-bbeznd3r	141	38	HSQC	HSQC	NNP
cord-001734-bbeznd3r	141	39	-	-	HYPH
cord-001734-bbeznd3r	141	40	TOCSY	TOCSY	NNP
cord-001734-bbeznd3r	141	41	/	/	SYM
cord-001734-bbeznd3r	141	42	HSQC	HSQC	NNP
cord-001734-bbeznd3r	141	43	-	-	HYPH
cord-001734-bbeznd3r	141	44	NOESY	NOESY	NNP
cord-001734-bbeznd3r	141	45	.	.	.
cord-001734-bbeznd3r	142	1	Fig	Fig	NNP
cord-001734-bbeznd3r	142	2	1C	1C	NNP
cord-001734-bbeznd3r	142	3	pres	pres	NNP
cord-001734-bbeznd3r	142	4	ents	ents	NNP
cord-001734-bbeznd3r	143	1	the	the	DT
cord-001734-bbeznd3r	143	2	obtained	obtain	VBN
cord-001734-bbeznd3r	143	3	(	(	-LRB-
cord-001734-bbeznd3r	143	4	ΔCα	δcα	NN
cord-001734-bbeznd3r	143	5	-	-	HYPH
cord-001734-bbeznd3r	143	6	ΔCβ	ΔCβ	NNP
cord-001734-bbeznd3r	143	7	)	)	-RRB-
cord-001734-bbeznd3r	143	8	chemical	chemical	NN
cord-001734-bbeznd3r	143	9	shifts	shift	NNS
cord-001734-bbeznd3r	143	10	,	,	,
cord-001734-bbeznd3r	143	11	which	which	WDT
cord-001734-bbeznd3r	143	12	is	be	VBZ
cord-001734-bbeznd3r	143	13	a	a	DT
cord-001734-bbeznd3r	143	14	sensitive	sensitive	JJ
cord-001734-bbeznd3r	143	15	indicator	indicator	NN
cord-001734-bbeznd3r	143	16	of	of	IN
cord-001734-bbeznd3r	143	17	the	the	DT
cord-001734-bbeznd3r	143	18	residual	residual	JJ
cord-001734-bbeznd3r	143	19	secondary	secondary	JJ
cord-001734-bbeznd3r	143	20	structures	structure	NNS
cord-001734-bbeznd3r	143	21	in	in	IN
cord-001734-bbeznd3r	143	22	disordered	disordered	JJ
cord-001734-bbeznd3r	143	23	proteins	protein	NNS
cord-001734-bbeznd3r	143	24	[	[	-LRB-
cord-001734-bbeznd3r	143	25	32	32	CD
cord-001734-bbeznd3r	143	26	]	]	-RRB-
cord-001734-bbeznd3r	143	27	.	.	.
cord-001734-bbeznd3r	144	1	Previously	previously	RB
cord-001734-bbeznd3r	144	2	,	,	,
cord-001734-bbeznd3r	144	3	by	by	IN
cord-001734-bbeznd3r	144	4	analyzing	analyze	VBG
cord-001734-bbeznd3r	144	5	NMR	NMR	NNP
cord-001734-bbeznd3r	144	6	chemical	chemical	NN
cord-001734-bbeznd3r	144	7	shifts	shift	NNS
cord-001734-bbeznd3r	144	8	,	,	,
cord-001734-bbeznd3r	144	9	the	the	DT
cord-001734-bbeznd3r	144	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	144	11	(	(	-LRB-
cord-001734-bbeznd3r	144	12	48	48	CD
cord-001734-bbeznd3r	144	13	-	-	SYM
cord-001734-bbeznd3r	144	14	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	144	15	(	(	-LRB-
cord-001734-bbeznd3r	144	16	14	14	CD
cord-001734-bbeznd3r	144	17	-	-	SYM
cord-001734-bbeznd3r	144	18	185	185	CD
cord-001734-bbeznd3r	144	19	)	)	-RRB-
cord-001734-bbeznd3r	144	20	complex	complex	NN
cord-001734-bbeznd3r	144	21	was	be	VBD
cord-001734-bbeznd3r	144	22	characterized	characterize	VBN
cord-001734-bbeznd3r	144	23	to	to	TO
cord-001734-bbeznd3r	144	24	adopt	adopt	VB
cord-001734-bbeznd3r	144	25	the	the	DT
cord-001734-bbeznd3r	144	26	same	same	JJ
cord-001734-bbeznd3r	144	27	structure	structure	NN
cord-001734-bbeznd3r	144	28	in	in	IN
cord-001734-bbeznd3r	144	29	solution	solution	NN
cord-001734-bbeznd3r	144	30	and	and	CC
cord-001734-bbeznd3r	144	31	crystal	crystal	NN
cord-001734-bbeznd3r	144	32	[	[	-LRB-
cord-001734-bbeznd3r	144	33	10	10	CD
cord-001734-bbeznd3r	144	34	]	]	-RRB-
cord-001734-bbeznd3r	144	35	.	.	.
cord-001734-bbeznd3r	145	1	Here	here	RB
cord-001734-bbeznd3r	145	2	we	-PRON-	PRP
cord-001734-bbeznd3r	145	3	downloaded	download	VBD
cord-001734-bbeznd3r	145	4	the	the	DT
cord-001734-bbeznd3r	145	5	chemical	chemical	NN
cord-001734-bbeznd3r	145	6	shifts	shift	NNS
cord-001734-bbeznd3r	145	7	of	of	IN
cord-001734-bbeznd3r	145	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	145	9	in	in	IN
cord-001734-bbeznd3r	145	10	complex	complex	NN
cord-001734-bbeznd3r	145	11	with	with	IN
cord-001734-bbeznd3r	145	12	NS2B	NS2B	NNP
cord-001734-bbeznd3r	145	13	(	(	-LRB-
cord-001734-bbeznd3r	145	14	BMRB	BMRB	NNP
cord-001734-bbeznd3r	145	15	ID	ID	NNP
cord-001734-bbeznd3r	145	16	of	of	IN
cord-001734-bbeznd3r	145	17	19080	19080	CD
cord-001734-bbeznd3r	145	18	)	)	-RRB-
cord-001734-bbeznd3r	145	19	and	and	CC
cord-001734-bbeznd3r	145	20	included	include	VBD
cord-001734-bbeznd3r	145	21	them	-PRON-	PRP
cord-001734-bbeznd3r	145	22	(	(	-LRB-
cord-001734-bbeznd3r	145	23	grey	grey	JJ
cord-001734-bbeznd3r	145	24	bars	bar	NNS
cord-001734-bbeznd3r	145	25	in	in	IN
cord-001734-bbeznd3r	145	26	Fig	Fig	NNP
cord-001734-bbeznd3r	145	27	1C	1c	NN
cord-001734-bbeznd3r	145	28	)	)	-RRB-
cord-001734-bbeznd3r	145	29	in	in	IN
cord-001734-bbeznd3r	145	30	parallel	parallel	NN
cord-001734-bbeznd3r	145	31	to	to	IN
cord-001734-bbeznd3r	145	32	those	those	DT
cord-001734-bbeznd3r	145	33	of	of	IN
cord-001734-bbeznd3r	145	34	the	the	DT
cord-001734-bbeznd3r	145	35	isolated	isolated	JJ
cord-001734-bbeznd3r	145	36	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	145	37	(	(	-LRB-
cord-001734-bbeznd3r	145	38	red	red	JJ
cord-001734-bbeznd3r	145	39	bars	bar	NNS
cord-001734-bbeznd3r	145	40	in	in	IN
cord-001734-bbeznd3r	145	41	Fig	Fig	NNP
cord-001734-bbeznd3r	145	42	1C	1c	NN
cord-001734-bbeznd3r	145	43	)	)	-RRB-
cord-001734-bbeznd3r	145	44	for	for	IN
cord-001734-bbeznd3r	145	45	comparison	comparison	NN
cord-001734-bbeznd3r	145	46	.	.	.
cord-001734-bbeznd3r	146	1	The	the	DT
cord-001734-bbeznd3r	146	2	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	146	3	domain	domain	NN
cord-001734-bbeznd3r	146	4	in	in	IN
cord-001734-bbeznd3r	146	5	complex	complex	NN
cord-001734-bbeznd3r	146	6	with	with	IN
cord-001734-bbeznd3r	146	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	146	8	has	have	VBZ
cord-001734-bbeznd3r	146	9	very	very	RB
cord-001734-bbeznd3r	146	10	large	large	JJ
cord-001734-bbeznd3r	146	11	(	(	-LRB-
cord-001734-bbeznd3r	146	12	ΔCα	δcα	NN
cord-001734-bbeznd3r	146	13	-	-	HYPH
cord-001734-bbeznd3r	146	14	ΔCβ	ΔCβ	NNS
cord-001734-bbeznd3r	146	15	)	)	-RRB-
cord-001734-bbeznd3r	146	16	deviations	deviation	NNS
cord-001734-bbeznd3r	146	17	characteristic	characteristic	JJ
cord-001734-bbeznd3r	146	18	of	of	IN
cord-001734-bbeznd3r	146	19	a	a	DT
cord-001734-bbeznd3r	146	20	well	well	RB
cord-001734-bbeznd3r	146	21	-	-	HYPH
cord-001734-bbeznd3r	146	22	folded	fold	VBN
cord-001734-bbeznd3r	146	23	protein	protein	NN
cord-001734-bbeznd3r	146	24	.	.	.
cord-001734-bbeznd3r	147	1	By	by	IN
cord-001734-bbeznd3r	147	2	contrast	contrast	NN
cord-001734-bbeznd3r	147	3	,	,	,
cord-001734-bbeznd3r	147	4	the	the	DT
cord-001734-bbeznd3r	147	5	isolated	isolated	JJ
cord-001734-bbeznd3r	147	6	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	147	7	has	have	VBZ
cord-001734-bbeznd3r	147	8	dramatically	dramatically	RB
cord-001734-bbeznd3r	147	9	decreased	decrease	VBN
cord-001734-bbeznd3r	147	10	(	(	-LRB-
cord-001734-bbeznd3r	147	11	ΔCα	δcα	NN
cord-001734-bbeznd3r	147	12	-	-	HYPH
cord-001734-bbeznd3r	147	13	ΔCβ	ΔCβ	NNP
cord-001734-bbeznd3r	147	14	)	)	-RRB-
cord-001734-bbeznd3r	147	15	over	over	IN
cord-001734-bbeznd3r	147	16	the	the	DT
cord-001734-bbeznd3r	147	17	whole	whole	JJ
cord-001734-bbeznd3r	147	18	sequence	sequence	NN
cord-001734-bbeznd3r	147	19	(	(	-LRB-
cord-001734-bbeznd3r	147	20	Fig	Fig	NNP
cord-001734-bbeznd3r	147	21	1C	1c	NN
cord-001734-bbeznd3r	147	22	)	)	-RRB-
cord-001734-bbeznd3r	147	23	.	.	.
cord-001734-bbeznd3r	148	1	For	for	IN
cord-001734-bbeznd3r	148	2	example	example	NN
cord-001734-bbeznd3r	148	3	,	,	,
cord-001734-bbeznd3r	148	4	many	many	JJ
cord-001734-bbeznd3r	148	5	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	148	6	residues	residue	NNS
cord-001734-bbeznd3r	148	7	in	in	IN
cord-001734-bbeznd3r	148	8	the	the	DT
cord-001734-bbeznd3r	148	9	complex	complex	NN
cord-001734-bbeznd3r	148	10	have	have	VBP
cord-001734-bbeznd3r	148	11	the	the	DT
cord-001734-bbeznd3r	148	12	absolute	absolute	JJ
cord-001734-bbeznd3r	148	13	values	value	NNS
cord-001734-bbeznd3r	148	14	of	of	IN
cord-001734-bbeznd3r	148	15	(	(	-LRB-
cord-001734-bbeznd3r	148	16	ΔCα	δcα	NN
cord-001734-bbeznd3r	148	17	-	-	HYPH
cord-001734-bbeznd3r	148	18	ΔCβ	δcβ	NN
cord-001734-bbeznd3r	148	19	)	)	-RRB-
cord-001734-bbeznd3r	148	20	>	>	XX
cord-001734-bbeznd3r	149	1	4	4	CD
cord-001734-bbeznd3r	149	2	ppm	ppm	NN
cord-001734-bbeznd3r	149	3	,	,	,
cord-001734-bbeznd3r	149	4	while	while	IN
cord-001734-bbeznd3r	149	5	all	all	DT
cord-001734-bbeznd3r	149	6	isolated	isolate	VBN
cord-001734-bbeznd3r	149	7	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	149	8	residues	residue	NNS
cord-001734-bbeznd3r	149	9	have	have	VBP
cord-001734-bbeznd3r	149	10	the	the	DT
cord-001734-bbeznd3r	149	11	absolute	absolute	JJ
cord-001734-bbeznd3r	149	12	values	value	NNS
cord-001734-bbeznd3r	149	13	of	of	IN
cord-001734-bbeznd3r	149	14	(	(	-LRB-
cord-001734-bbeznd3r	149	15	ΔCα	δcα	NN
cord-001734-bbeznd3r	149	16	-	-	HYPH
cord-001734-bbeznd3r	149	17	ΔCβ	ΔCβ	NNP
cord-001734-bbeznd3r	149	18	)	)	-RRB-
cord-001734-bbeznd3r	150	1	<	<	XX
cord-001734-bbeznd3r	151	1	2	2	CD
cord-001734-bbeznd3r	151	2	ppm	ppm	NN
cord-001734-bbeznd3r	151	3	.	.	.
cord-001734-bbeznd3r	152	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	152	2	,	,	,
cord-001734-bbeznd3r	152	3	many	many	JJ
cord-001734-bbeznd3r	152	4	residues	residue	NNS
cord-001734-bbeznd3r	152	5	of	of	IN
cord-001734-bbeznd3r	152	6	the	the	DT
cord-001734-bbeznd3r	152	7	isolated	isolated	JJ
cord-001734-bbeznd3r	152	8	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	152	9	still	still	RB
cord-001734-bbeznd3r	152	10	have	have	VBP
cord-001734-bbeznd3r	152	11	the	the	DT
cord-001734-bbeznd3r	152	12	(	(	-LRB-
cord-001734-bbeznd3r	152	13	ΔCα	δcα	NN
cord-001734-bbeznd3r	152	14	-	-	HYPH
cord-001734-bbeznd3r	152	15	ΔCβ	ΔCβ	NNS
cord-001734-bbeznd3r	152	16	)	)	-RRB-
cord-001734-bbeznd3r	152	17	patterns	pattern	NNS
cord-001734-bbeznd3r	152	18	similar	similar	JJ
cord-001734-bbeznd3r	152	19	to	to	IN
cord-001734-bbeznd3r	152	20	those	those	DT
cord-001734-bbeznd3r	152	21	in	in	IN
cord-001734-bbeznd3r	152	22	the	the	DT
cord-001734-bbeznd3r	152	23	complex	complex	NN
cord-001734-bbeznd3r	152	24	,	,	,
cord-001734-bbeznd3r	152	25	implying	imply	VBG
cord-001734-bbeznd3r	152	26	that	that	IN
cord-001734-bbeznd3r	152	27	similar	similar	JJ
cord-001734-bbeznd3r	152	28	secondary	secondary	JJ
cord-001734-bbeznd3r	152	29	structures	structure	NNS
cord-001734-bbeznd3r	152	30	might	may	MD
cord-001734-bbeznd3r	152	31	be	be	VB
cord-001734-bbeznd3r	152	32	weakly	weakly	RB
cord-001734-bbeznd3r	152	33	populated	populated	JJ
cord-001734-bbeznd3r	152	34	over	over	IN
cord-001734-bbeznd3r	152	35	these	these	DT
cord-001734-bbeznd3r	152	36	residues	residue	NNS
cord-001734-bbeznd3r	152	37	.	.	.
cord-001734-bbeznd3r	153	1	Indeed	indeed	RB
cord-001734-bbeznd3r	153	2	,	,	,
cord-001734-bbeznd3r	153	3	we	-PRON-	PRP
cord-001734-bbeznd3r	153	4	further	further	RB
cord-001734-bbeznd3r	153	5	analysed	analyse	VBD
cord-001734-bbeznd3r	153	6	the	the	DT
cord-001734-bbeznd3r	153	7	NH	NH	NNP
cord-001734-bbeznd3r	153	8	,	,	,
cord-001734-bbeznd3r	153	9	15	15	CD
cord-001734-bbeznd3r	153	10	N	n	CD
cord-001734-bbeznd3r	153	11	,	,	,
cord-001734-bbeznd3r	153	12	Cα	Cα	NNP
cord-001734-bbeznd3r	153	13	and	and	CC
cord-001734-bbeznd3r	153	14	Cβ	Cβ	NNP
cord-001734-bbeznd3r	153	15	chemical	chemical	NN
cord-001734-bbeznd3r	153	16	shifts	shift	NNS
cord-001734-bbeznd3r	153	17	by	by	IN
cord-001734-bbeznd3r	153	18	Delta2D	delta2d	NN
cord-001734-bbeznd3r	153	19	program	program	NN
cord-001734-bbeznd3r	153	20	[	[	-LRB-
cord-001734-bbeznd3r	153	21	26	26	CD
cord-001734-bbeznd3r	153	22	]	]	-RRB-
cord-001734-bbeznd3r	153	23	and	and	CC
cord-001734-bbeznd3r	153	24	the	the	DT
cord-001734-bbeznd3r	153	25	results	result	NNS
cord-001734-bbeznd3r	153	26	indicate	indicate	VBP
cord-001734-bbeznd3r	153	27	that	that	IN
cord-001734-bbeznd3r	153	28	the	the	DT
cord-001734-bbeznd3r	153	29	isolated	isolated	JJ
cord-001734-bbeznd3r	153	30	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	153	31	adopts	adopt	VBZ
cord-001734-bbeznd3r	153	32	highly	highly	RB
cord-001734-bbeznd3r	153	33	-	-	HYPH
cord-001734-bbeznd3r	153	34	populated	populated	JJ
cord-001734-bbeznd3r	153	35	random	random	JJ
cord-001734-bbeznd3r	153	36	coil	coil	NN
cord-001734-bbeznd3r	153	37	conformations	conformation	NNS
cord-001734-bbeznd3r	153	38	over	over	IN
cord-001734-bbeznd3r	153	39	the	the	DT
cord-001734-bbeznd3r	153	40	whole	whole	JJ
cord-001734-bbeznd3r	153	41	sequence	sequence	NN
cord-001734-bbeznd3r	153	42	.	.	.
cord-001734-bbeznd3r	154	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	154	2	,	,	,
cord-001734-bbeznd3r	154	3	over	over	IN
cord-001734-bbeznd3r	154	4	some	some	DT
cord-001734-bbeznd3r	154	5	short	short	JJ
cord-001734-bbeznd3r	154	6	segments	segment	NNS
cord-001734-bbeznd3r	154	7	,	,	,
cord-001734-bbeznd3r	154	8	the	the	DT
cord-001734-bbeznd3r	154	9	extended	extended	JJ
cord-001734-bbeznd3r	154	10	strand	strand	NN
cord-001734-bbeznd3r	154	11	conformation	conformation	NN
cord-001734-bbeznd3r	154	12	is	be	VBZ
cord-001734-bbeznd3r	154	13	also	also	RB
cord-001734-bbeznd3r	154	14	populated	populated	JJ
cord-001734-bbeznd3r	154	15	to	to	IN
cord-001734-bbeznd3r	154	16	some	some	DT
cord-001734-bbeznd3r	154	17	degree	degree	NN
cord-001734-bbeznd3r	154	18	but	but	CC
cord-001734-bbeznd3r	154	19	the	the	DT
cord-001734-bbeznd3r	154	20	helix	helix	NN
cord-001734-bbeznd3r	154	21	conformation	conformation	NN
cord-001734-bbeznd3r	154	22	is	be	VBZ
cord-001734-bbeznd3r	154	23	almost	almost	RB
cord-001734-bbeznd3r	154	24	lacking	lacking	JJ
cord-001734-bbeznd3r	154	25	(	(	-LRB-
cord-001734-bbeznd3r	154	26	Fig	Fig	NNP
cord-001734-bbeznd3r	154	27	1D	1d	CD
cord-001734-bbeznd3r	154	28	)	)	-RRB-
cord-001734-bbeznd3r	154	29	,	,	,
cord-001734-bbeznd3r	154	30	completely	completely	RB
cord-001734-bbeznd3r	154	31	consistent	consistent	JJ
cord-001734-bbeznd3r	154	32	with	with	IN
cord-001734-bbeznd3r	154	33	the	the	DT
cord-001734-bbeznd3r	154	34	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	154	35	result	result	NN
cord-001734-bbeznd3r	154	36	of	of	IN
cord-001734-bbeznd3r	154	37	the	the	DT
cord-001734-bbeznd3r	154	38	CD	cd	NN
cord-001734-bbeznd3r	154	39	spectrum	spectrum	NN
cord-001734-bbeznd3r	154	40	.	.	.
cord-001734-bbeznd3r	155	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	155	2	,	,	,
cord-001734-bbeznd3r	155	3	as	as	IN
cord-001734-bbeznd3r	155	4	seen	see	VBN
cord-001734-bbeznd3r	155	5	in	in	IN
cord-001734-bbeznd3r	155	6	Fig	Fig	NNP
cord-001734-bbeznd3r	155	7	1E	1e	CD
cord-001734-bbeznd3r	155	8	,	,	,
cord-001734-bbeznd3r	155	9	only	only	RB
cord-001734-bbeznd3r	155	10	sequential	sequential	JJ
cord-001734-bbeznd3r	155	11	NOEs	no	NNS
cord-001734-bbeznd3r	155	12	d	d	NNP
cord-001734-bbeznd3r	155	13	NN(i	NN(i	NNP
cord-001734-bbeznd3r	155	14	,	,	,
cord-001734-bbeznd3r	155	15	i+1	i+1	NN
cord-001734-bbeznd3r	155	16	)	)	-RRB-
cord-001734-bbeznd3r	155	17	and	and	CC
cord-001734-bbeznd3r	155	18	d	d	NNP
cord-001734-bbeznd3r	155	19	αN(i	αN(i	NNP
cord-001734-bbeznd3r	155	20	,	,	,
cord-001734-bbeznd3r	155	21	i+1	i+1	,
cord-001734-bbeznd3r	155	22	)	)	-RRB-
cord-001734-bbeznd3r	155	23	manifest	manifest	VB
cord-001734-bbeznd3r	155	24	over	over	IN
cord-001734-bbeznd3r	155	25	the	the	DT
cord-001734-bbeznd3r	155	26	majority	majority	NN
cord-001734-bbeznd3r	155	27	of	of	IN
cord-001734-bbeznd3r	155	28	the	the	DT
cord-001734-bbeznd3r	155	29	sequence	sequence	NN
cord-001734-bbeznd3r	155	30	,	,	,
cord-001734-bbeznd3r	155	31	clearly	clearly	RB
cord-001734-bbeznd3r	155	32	indicating	indicate	VBG
cord-001734-bbeznd3r	155	33	that	that	IN
cord-001734-bbeznd3r	155	34	the	the	DT
cord-001734-bbeznd3r	155	35	isolated	isolated	JJ
cord-001734-bbeznd3r	155	36	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	155	37	has	have	VBZ
cord-001734-bbeznd3r	155	38	no	no	DT
cord-001734-bbeznd3r	155	39	stable	stable	JJ
cord-001734-bbeznd3r	155	40	secondary	secondary	JJ
cord-001734-bbeznd3r	155	41	structures	structure	NNS
cord-001734-bbeznd3r	155	42	and	and	CC
cord-001734-bbeznd3r	155	43	its	-PRON-	PRP$
cord-001734-bbeznd3r	155	44	NMR	NMR	NNP
cord-001734-bbeznd3r	155	45	conformation	conformation	NN
cord-001734-bbeznd3r	156	1	represents	represent	VBZ
cord-001734-bbeznd3r	156	2	an	an	DT
cord-001734-bbeznd3r	156	3	average	average	NN
cord-001734-bbeznd3r	156	4	of	of	IN
cord-001734-bbeznd3r	156	5	an	an	DT
cord-001734-bbeznd3r	156	6	ensemble	ensemble	NN
cord-001734-bbeznd3r	156	7	of	of	IN
cord-001734-bbeznd3r	156	8	different	different	JJ
cord-001734-bbeznd3r	156	9	structures	structure	NNS
cord-001734-bbeznd3r	156	10	.	.	.
cord-001734-bbeznd3r	157	1	Taken	take	VBN
cord-001734-bbeznd3r	157	2	together	together	RB
cord-001734-bbeznd3r	157	3	,	,	,
cord-001734-bbeznd3r	157	4	CD	CD	NNP
cord-001734-bbeznd3r	157	5	and	and	CC
cord-001734-bbeznd3r	157	6	NMR	NMR	NNP
cord-001734-bbeznd3r	157	7	results	result	NNS
cord-001734-bbeznd3r	157	8	define	define	VBP
cord-001734-bbeznd3r	157	9	the	the	DT
cord-001734-bbeznd3r	157	10	172-residue	172-residue	CD
cord-001734-bbeznd3r	157	11	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	157	12	domain	domain	NN
cord-001734-bbeznd3r	157	13	to	to	TO
cord-001734-bbeznd3r	157	14	be	be	VB
cord-001734-bbeznd3r	157	15	an	an	DT
cord-001734-bbeznd3r	157	16	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	157	17	disordered	disordered	JJ
cord-001734-bbeznd3r	157	18	protein	protein	NN
cord-001734-bbeznd3r	157	19	which	which	WDT
cord-001734-bbeznd3r	157	20	is	be	VBZ
cord-001734-bbeznd3r	157	21	lacking	lack	VBG
cord-001734-bbeznd3r	157	22	of	of	IN
cord-001734-bbeznd3r	157	23	both	both	DT
cord-001734-bbeznd3r	157	24	stable	stable	JJ
cord-001734-bbeznd3r	157	25	secondary	secondary	JJ
cord-001734-bbeznd3r	157	26	and	and	CC
cord-001734-bbeznd3r	157	27	tertiary	tertiary	JJ
cord-001734-bbeznd3r	157	28	structures	structure	NNS
cord-001734-bbeznd3r	157	29	in	in	IN
cord-001734-bbeznd3r	157	30	the	the	DT
cord-001734-bbeznd3r	157	31	absence	absence	NN
cord-001734-bbeznd3r	157	32	of	of	IN
cord-001734-bbeznd3r	157	33	the	the	DT
cord-001734-bbeznd3r	157	34	NS2B	NS2B	NNP
cord-001734-bbeznd3r	157	35	cofactor	cofactor	NN
cord-001734-bbeznd3r	157	36	[	[	-LRB-
cord-001734-bbeznd3r	157	37	22	22	CD
cord-001734-bbeznd3r	157	38	,	,	,
cord-001734-bbeznd3r	157	39	[	[	-LRB-
cord-001734-bbeznd3r	157	40	31	31	CD
cord-001734-bbeznd3r	157	41	]	]	-RRB-
cord-001734-bbeznd3r	158	1	[	[	-LRB-
cord-001734-bbeznd3r	158	2	32	32	CD
cord-001734-bbeznd3r	158	3	]	]	-RRB-
cord-001734-bbeznd3r	158	4	[	[	-LRB-
cord-001734-bbeznd3r	158	5	33	33	CD
cord-001734-bbeznd3r	158	6	]	]	-RRB-
cord-001734-bbeznd3r	158	7	[	[	-LRB-
cord-001734-bbeznd3r	158	8	34	34	CD
cord-001734-bbeznd3r	158	9	]	]	-RRB-
cord-001734-bbeznd3r	159	1	[	[	-LRB-
cord-001734-bbeznd3r	159	2	35	35	CD
cord-001734-bbeznd3r	159	3	]	]	-RRB-
cord-001734-bbeznd3r	159	4	[	[	-LRB-
cord-001734-bbeznd3r	159	5	36	36	CD
cord-001734-bbeznd3r	159	6	]	]	-RRB-
cord-001734-bbeznd3r	159	7	.	.	.
cord-001734-bbeznd3r	160	1	To	to	TO
cord-001734-bbeznd3r	160	2	pinpoint	pinpoint	VB
cord-001734-bbeznd3r	160	3	the	the	DT
cord-001734-bbeznd3r	160	4	backbone	backbone	NN
cord-001734-bbeznd3r	160	5	flexibility	flexibility	NN
cord-001734-bbeznd3r	160	6	,	,	,
cord-001734-bbeznd3r	160	7	we	-PRON-	PRP
cord-001734-bbeznd3r	160	8	measured	measure	VBD
cord-001734-bbeznd3r	160	9	the	the	DT
cord-001734-bbeznd3r	160	10	{	{	-LRB-
cord-001734-bbeznd3r	160	11	1	1	CD
cord-001734-bbeznd3r	160	12	H}-15	H}-15	NNP
cord-001734-bbeznd3r	160	13	N	n	CD
cord-001734-bbeznd3r	160	14	heteronuclear	heteronuclear	NN
cord-001734-bbeznd3r	160	15	steady	steady	JJ
cord-001734-bbeznd3r	160	16	-	-	HYPH
cord-001734-bbeznd3r	160	17	state	state	NN
cord-001734-bbeznd3r	160	18	NOE	NOE	NNP
cord-001734-bbeznd3r	160	19	(	(	-LRB-
cord-001734-bbeznd3r	160	20	hNOE	hnoe	NN
cord-001734-bbeznd3r	160	21	)	)	-RRB-
cord-001734-bbeznd3r	160	22	of	of	IN
cord-001734-bbeznd3r	160	23	the	the	DT
cord-001734-bbeznd3r	160	24	isolated	isolated	JJ
cord-001734-bbeznd3r	160	25	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	160	26	,	,	,
cord-001734-bbeznd3r	160	27	which	which	WDT
cord-001734-bbeznd3r	160	28	is	be	VBZ
cord-001734-bbeznd3r	160	29	a	a	DT
cord-001734-bbeznd3r	160	30	measure	measure	NN
cord-001734-bbeznd3r	160	31	of	of	IN
cord-001734-bbeznd3r	160	32	the	the	DT
cord-001734-bbeznd3r	160	33	backbone	backbone	NN
cord-001734-bbeznd3r	160	34	motions	motion	NNS
cord-001734-bbeznd3r	160	35	on	on	IN
cord-001734-bbeznd3r	160	36	the	the	DT
cord-001734-bbeznd3r	160	37	psns	psns	JJ
cord-001734-bbeznd3r	160	38	time	time	NN
cord-001734-bbeznd3r	160	39	scale	scale	NN
cord-001734-bbeznd3r	160	40	[	[	-LRB-
cord-001734-bbeznd3r	160	41	18	18	CD
cord-001734-bbeznd3r	160	42	,	,	,
cord-001734-bbeznd3r	160	43	19	19	CD
cord-001734-bbeznd3r	160	44	,	,	,
cord-001734-bbeznd3r	160	45	31	31	CD
cord-001734-bbeznd3r	160	46	,	,	,
cord-001734-bbeznd3r	160	47	32	32	CD
cord-001734-bbeznd3r	160	48	,	,	,
cord-001734-bbeznd3r	160	49	37	37	CD
cord-001734-bbeznd3r	160	50	]	]	-RRB-
cord-001734-bbeznd3r	160	51	.	.	.
cord-001734-bbeznd3r	161	1	Previously	previously	RB
cord-001734-bbeznd3r	161	2	,	,	,
cord-001734-bbeznd3r	161	3	all	all	RB
cord-001734-bbeznd3r	161	4	except	except	IN
cord-001734-bbeznd3r	161	5	for	for	IN
cord-001734-bbeznd3r	161	6	several	several	JJ
cord-001734-bbeznd3r	161	7	C	c	NN
cord-001734-bbeznd3r	161	8	-	-	HYPH
cord-001734-bbeznd3r	161	9	terminal	terminal	NN
cord-001734-bbeznd3r	161	10	residues	residue	NNS
cord-001734-bbeznd3r	161	11	of	of	IN
cord-001734-bbeznd3r	161	12	the	the	DT
cord-001734-bbeznd3r	161	13	complexed	complexed	JJ
cord-001734-bbeznd3r	161	14	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	161	15	were	be	VBD
cord-001734-bbeznd3r	161	16	shown	show	VBN
cord-001734-bbeznd3r	161	17	to	to	TO
cord-001734-bbeznd3r	161	18	have	have	VB
cord-001734-bbeznd3r	161	19	positive	positive	JJ
cord-001734-bbeznd3r	161	20	hNOE	hnoe	NN
cord-001734-bbeznd3r	161	21	values	value	NNS
cord-001734-bbeznd3r	161	22	,	,	,
cord-001734-bbeznd3r	161	23	with	with	IN
cord-001734-bbeznd3r	161	24	many	many	JJ
cord-001734-bbeznd3r	161	25	even	even	RB
cord-001734-bbeznd3r	161	26	close	close	JJ
cord-001734-bbeznd3r	161	27	to	to	IN
cord-001734-bbeznd3r	161	28	1	1	CD
cord-001734-bbeznd3r	161	29	,	,	,
cord-001734-bbeznd3r	161	30	clearly	clearly	RB
cord-001734-bbeznd3r	161	31	indicating	indicate	VBG
cord-001734-bbeznd3r	161	32	that	that	IN
cord-001734-bbeznd3r	161	33	the	the	DT
cord-001734-bbeznd3r	161	34	backbone	backbone	NN
cord-001734-bbeznd3r	161	35	of	of	IN
cord-001734-bbeznd3r	161	36	the	the	DT
cord-001734-bbeznd3r	161	37	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	161	38	in	in	IN
cord-001734-bbeznd3r	161	39	the	the	DT
cord-001734-bbeznd3r	161	40	complex	complex	NN
cord-001734-bbeznd3r	161	41	is	be	VBZ
cord-001734-bbeznd3r	161	42	very	very	RB
cord-001734-bbeznd3r	161	43	rigid	rigid	JJ
cord-001734-bbeznd3r	161	44	[	[	-LRB-
cord-001734-bbeznd3r	161	45	10	10	CD
cord-001734-bbeznd3r	161	46	]	]	-RRB-
cord-001734-bbeznd3r	161	47	.	.	.
cord-001734-bbeznd3r	162	1	By	by	IN
cord-001734-bbeznd3r	162	2	contrast	contrast	NN
cord-001734-bbeznd3r	162	3	,	,	,
cord-001734-bbeznd3r	162	4	residues	residue	NNS
cord-001734-bbeznd3r	162	5	of	of	IN
cord-001734-bbeznd3r	162	6	the	the	DT
cord-001734-bbeznd3r	162	7	isolated	isolated	JJ
cord-001734-bbeznd3r	162	8	NS3pro	NS3pro	NNS
cord-001734-bbeznd3r	162	9	have	have	VBP
cord-001734-bbeznd3r	162	10	small	small	JJ
cord-001734-bbeznd3r	162	11	or	or	CC
cord-001734-bbeznd3r	162	12	even	even	RB
cord-001734-bbeznd3r	162	13	negative	negative	JJ
cord-001734-bbeznd3r	162	14	hNOEs	hnoe	NNS
cord-001734-bbeznd3r	163	1	(	(	-LRB-
cord-001734-bbeznd3r	163	2	Fig	Fig	NNP
cord-001734-bbeznd3r	163	3	2A	2a	CD
cord-001734-bbeznd3r	163	4	)	)	-RRB-
cord-001734-bbeznd3r	163	5	,	,	,
cord-001734-bbeznd3r	163	6	with	with	IN
cord-001734-bbeznd3r	163	7	an	an	DT
cord-001734-bbeznd3r	163	8	average	average	JJ
cord-001734-bbeznd3r	163	9	hNOE	hnoe	NN
cord-001734-bbeznd3r	163	10	of	of	IN
cord-001734-bbeznd3r	163	11	only	only	JJ
cord-001734-bbeznd3r	163	12	0.08	0.08	CD
cord-001734-bbeznd3r	163	13	.	.	.
cord-001734-bbeznd3r	164	1	More	more	RBR
cord-001734-bbeznd3r	164	2	specifically	specifically	RB
cord-001734-bbeznd3r	164	3	,	,	,
cord-001734-bbeznd3r	164	4	all	all	DT
cord-001734-bbeznd3r	164	5	residues	residue	NNS
cord-001734-bbeznd3r	164	6	have	have	VBP
cord-001734-bbeznd3r	164	7	hNOE	hnoe	NN
cord-001734-bbeznd3r	164	8	values	value	NNS
cord-001734-bbeznd3r	164	9	<	<	XX
cord-001734-bbeznd3r	164	10	0.4	0.4	CD
cord-001734-bbeznd3r	164	11	,	,	,
cord-001734-bbeznd3r	164	12	while	while	IN
cord-001734-bbeznd3r	164	13	many	many	JJ
cord-001734-bbeznd3r	164	14	residues	residue	NNS
cord-001734-bbeznd3r	164	15	even	even	RB
cord-001734-bbeznd3r	164	16	have	have	VBP
cord-001734-bbeznd3r	164	17	negative	negative	JJ
cord-001734-bbeznd3r	164	18	hNOE	hnoe	NN
cord-001734-bbeznd3r	164	19	,	,	,
cord-001734-bbeznd3r	164	20	such	such	JJ
cord-001734-bbeznd3r	164	21	as	as	IN
cord-001734-bbeznd3r	164	22	N-/C	N-/C	NNP
cord-001734-bbeznd3r	164	23	-	-	HYPH
cord-001734-bbeznd3r	164	24	termini	termini	NNP
cord-001734-bbeznd3r	164	25	,	,	,
cord-001734-bbeznd3r	164	26	Ser34-Gly39	Ser34-Gly39	NNP
cord-001734-bbeznd3r	164	27	,	,	,
cord-001734-bbeznd3r	164	28	Arg54-Arg64	Arg54-Arg64	NNP
cord-001734-bbeznd3r	164	29	,	,	,
cord-001734-bbeznd3r	164	30	Gln110-Ile139	Gln110-Ile139	NNP
cord-001734-bbeznd3r	164	31	and	and	CC
cord-001734-bbeznd3r	164	32	Arg157-Gly159	Arg157-Gly159	NNP
cord-001734-bbeznd3r	164	33	(	(	-LRB-
cord-001734-bbeznd3r	164	34	Fig	Fig	NNP
cord-001734-bbeznd3r	164	35	2A	2a	CD
cord-001734-bbeznd3r	164	36	)	)	-RRB-
cord-001734-bbeznd3r	164	37	.	.	.
cord-001734-bbeznd3r	165	1	This	this	DT
cord-001734-bbeznd3r	165	2	strongly	strongly	RB
cord-001734-bbeznd3r	165	3	suggests	suggest	VBZ
cord-001734-bbeznd3r	165	4	that	that	IN
cord-001734-bbeznd3r	165	5	the	the	DT
cord-001734-bbeznd3r	165	6	isolated	isolated	JJ
cord-001734-bbeznd3r	165	7	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	165	8	has	have	VBZ
cord-001734-bbeznd3r	165	9	largely	largely	RB
cord-001734-bbeznd3r	165	10	unrestricted	unrestricted	JJ
cord-001734-bbeznd3r	165	11	backbone	backbone	NN
cord-001734-bbeznd3r	165	12	motions	motion	NNS
cord-001734-bbeznd3r	165	13	on	on	IN
cord-001734-bbeznd3r	165	14	the	the	DT
cord-001734-bbeznd3r	165	15	ps	ps	NNP
cord-001734-bbeznd3r	165	16	-	-	HYPH
cord-001734-bbeznd3r	165	17	ns	ns	NNP
cord-001734-bbeznd3r	165	18	time	time	NN
cord-001734-bbeznd3r	165	19	scale	scale	NN
cord-001734-bbeznd3r	165	20	,	,	,
cord-001734-bbeznd3r	165	21	consistent	consistent	JJ
cord-001734-bbeznd3r	165	22	with	with	IN
cord-001734-bbeznd3r	165	23	its	-PRON-	PRP$
cord-001734-bbeznd3r	165	24	absence	absence	NN
cord-001734-bbeznd3r	165	25	of	of	IN
cord-001734-bbeznd3r	165	26	any	any	DT
cord-001734-bbeznd3r	165	27	stable	stable	JJ
cord-001734-bbeznd3r	165	28	secondary	secondary	JJ
cord-001734-bbeznd3r	165	29	and	and	CC
cord-001734-bbeznd3r	165	30	tertiary	tertiary	JJ
cord-001734-bbeznd3r	165	31	structures	structure	NNS
cord-001734-bbeznd3r	165	32	.	.	.
cord-001734-bbeznd3r	166	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	166	2	,	,	,
cord-001734-bbeznd3r	166	3	residues	residue	NNS
cord-001734-bbeznd3r	166	4	over	over	IN
cord-001734-bbeznd3r	166	5	Ile65-Leu100	Ile65-Leu100	NNP
cord-001734-bbeznd3r	166	6	have	have	VBP
cord-001734-bbeznd3r	166	7	relatively	relatively	RB
cord-001734-bbeznd3r	166	8	large	large	JJ
cord-001734-bbeznd3r	166	9	hNOE	hnoe	NN
cord-001734-bbeznd3r	166	10	,	,	,
cord-001734-bbeznd3r	166	11	implying	imply	VBG
cord-001734-bbeznd3r	166	12	that	that	IN
cord-001734-bbeznd3r	166	13	this	this	DT
cord-001734-bbeznd3r	166	14	region	region	NN
cord-001734-bbeznd3r	166	15	might	may	MD
cord-001734-bbeznd3r	166	16	have	have	VB
cord-001734-bbeznd3r	166	17	transit	transit	NN
cord-001734-bbeznd3r	166	18	tertiary	tertiary	JJ
cord-001734-bbeznd3r	166	19	packing	packing	NN
cord-001734-bbeznd3r	166	20	to	to	IN
cord-001734-bbeznd3r	166	21	a	a	DT
cord-001734-bbeznd3r	166	22	certain	certain	JJ
cord-001734-bbeznd3r	166	23	degree	degree	NN
cord-001734-bbeznd3r	166	24	.	.	.
cord-001734-bbeznd3r	167	1	Previously	previously	RB
cord-001734-bbeznd3r	167	2	many	many	JJ
cord-001734-bbeznd3r	167	3	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	167	4	disordered	disordered	JJ
cord-001734-bbeznd3r	167	5	proteins	protein	NNS
cord-001734-bbeznd3r	167	6	such	such	JJ
cord-001734-bbeznd3r	167	7	as	as	IN
cord-001734-bbeznd3r	167	8	α	α	NNP
cord-001734-bbeznd3r	167	9	-	-	HYPH
cord-001734-bbeznd3r	167	10	synuclein	synuclein	NNP
cord-001734-bbeznd3r	167	11	have	have	VBP
cord-001734-bbeznd3r	167	12	been	be	VBN
cord-001734-bbeznd3r	167	13	shown	show	VBN
cord-001734-bbeznd3r	167	14	to	to	TO
cord-001734-bbeznd3r	167	15	have	have	VB
cord-001734-bbeznd3r	167	16	transient	transient	JJ
cord-001734-bbeznd3r	167	17	long	long	JJ
cord-001734-bbeznd3r	167	18	-	-	HYPH
cord-001734-bbeznd3r	167	19	range	range	NN
cord-001734-bbeznd3r	167	20	interactions	interaction	NNS
cord-001734-bbeznd3r	167	21	by	by	IN
cord-001734-bbeznd3r	167	22	measurements	measurement	NNS
cord-001734-bbeznd3r	167	23	of	of	IN
cord-001734-bbeznd3r	167	24	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	167	25	relaxation	relaxation	NN
cord-001734-bbeznd3r	167	26	enhancement	enhancement	NN
cord-001734-bbeznd3r	167	27	(	(	-LRB-
cord-001734-bbeznd3r	167	28	PRE	PRE	NNP
cord-001734-bbeznd3r	167	29	)	)	-RRB-
cord-001734-bbeznd3r	167	30	,	,	,
cord-001734-bbeznd3r	167	31	which	which	WDT
cord-001734-bbeznd3r	167	32	is	be	VBZ
cord-001734-bbeznd3r	167	33	a	a	DT
cord-001734-bbeznd3r	167	34	powerful	powerful	JJ
cord-001734-bbeznd3r	167	35	tool	tool	NN
cord-001734-bbeznd3r	167	36	in	in	IN
cord-001734-bbeznd3r	167	37	detecting	detect	VBG
cord-001734-bbeznd3r	167	38	transiently	transiently	RB
cord-001734-bbeznd3r	167	39	existing	exist	VBG
cord-001734-bbeznd3r	167	40	contacts	contact	NNS
cord-001734-bbeznd3r	167	41	in	in	IN
cord-001734-bbeznd3r	167	42	highly	highly	RB
cord-001734-bbeznd3r	167	43	disordered	disordered	JJ
cord-001734-bbeznd3r	167	44	proteins	protein	NNS
cord-001734-bbeznd3r	167	45	with	with	IN
cord-001734-bbeznd3r	167	46	distances	distance	NNS
cord-001734-bbeznd3r	167	47	up	up	IN
cord-001734-bbeznd3r	167	48	to~25	to~25	NNP
cord-001734-bbeznd3r	167	49	Å	Å	NNP
cord-001734-bbeznd3r	167	50	[	[	-LRB-
cord-001734-bbeznd3r	167	51	18	18	CD
cord-001734-bbeznd3r	167	52	,	,	,
cord-001734-bbeznd3r	167	53	32	32	CD
cord-001734-bbeznd3r	167	54	,	,	,
cord-001734-bbeznd3r	167	55	38	38	CD
cord-001734-bbeznd3r	167	56	]	]	-RRB-
cord-001734-bbeznd3r	167	57	.	.	.
cord-001734-bbeznd3r	168	1	Here	here	RB
cord-001734-bbeznd3r	168	2	,	,	,
cord-001734-bbeznd3r	168	3	by	by	IN
cord-001734-bbeznd3r	168	4	site	site	NN
cord-001734-bbeznd3r	168	5	-	-	HYPH
cord-001734-bbeznd3r	168	6	directed	direct	VBN
cord-001734-bbeznd3r	168	7	mutagenesis	mutagenesis	NN
cord-001734-bbeznd3r	168	8	,	,	,
cord-001734-bbeznd3r	168	9	we	-PRON-	PRP
cord-001734-bbeznd3r	168	10	introduced	introduce	VBD
cord-001734-bbeznd3r	168	11	Cys	Cys	NNP
cord-001734-bbeznd3r	168	12	residue	residue	NN
cord-001734-bbeznd3r	168	13	into	into	IN
cord-001734-bbeznd3r	168	14	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	168	15	one	one	CD
cord-001734-bbeznd3r	168	16	by	by	IN
cord-001734-bbeznd3r	168	17	one	one	CD
cord-001734-bbeznd3r	168	18	at	at	IN
cord-001734-bbeznd3r	168	19	three	three	CD
cord-001734-bbeznd3r	168	20	locations	location	NNS
cord-001734-bbeznd3r	168	21	:	:	:
cord-001734-bbeznd3r	168	22	Gln27	Gln27	NNP
cord-001734-bbeznd3r	168	23	,	,	,
cord-001734-bbeznd3r	168	24	Glu86	Glu86	NNP
cord-001734-bbeznd3r	168	25	and	and	CC
cord-001734-bbeznd3r	168	26	Ser158	Ser158	.
cord-001734-bbeznd3r	169	1	(	(	-LRB-
cord-001734-bbeznd3r	169	2	S1	S1	NNP
cord-001734-bbeznd3r	169	3	Fig	Fig	NNP
cord-001734-bbeznd3r	169	4	)	)	-RRB-
cord-001734-bbeznd3r	169	5	.	.	.
cord-001734-bbeznd3r	170	1	Three	three	CD
cord-001734-bbeznd3r	170	2	single	single	JJ
cord-001734-bbeznd3r	170	3	Cys	Cys	NNP
cord-001734-bbeznd3r	170	4	mutants	mutant	NNS
cord-001734-bbeznd3r	170	5	were	be	VBD
cord-001734-bbeznd3r	170	6	subsequently	subsequently	RB
cord-001734-bbeznd3r	170	7	labelled	label	VBN
cord-001734-bbeznd3r	170	8	with	with	IN
cord-001734-bbeznd3r	170	9	the	the	DT
cord-001734-bbeznd3r	170	10	nitroxide	nitroxide	NNP
cord-001734-bbeznd3r	170	11	free	free	JJ
cord-001734-bbeznd3r	170	12	radical	radical	JJ
cord-001734-bbeznd3r	170	13	probe	probe	NN
cord-001734-bbeznd3r	170	14	,	,	,
cord-001734-bbeznd3r	170	15	MTSSL	MTSSL	NNP
cord-001734-bbeznd3r	170	16	whose	whose	WP$
cord-001734-bbeznd3r	170	17	PRE	PRE	NNP
cord-001734-bbeznd3r	170	18	were	be	VBD
cord-001734-bbeznd3r	170	19	measured	measure	VBN
cord-001734-bbeznd3r	170	20	by	by	IN
cord-001734-bbeznd3r	170	21	HSQC	HSQC	NNP
cord-001734-bbeznd3r	170	22	(	(	-LRB-
cord-001734-bbeznd3r	170	23	S1	S1	NNP
cord-001734-bbeznd3r	170	24	Fig	Fig	NNP
cord-001734-bbeznd3r	170	25	)	)	-RRB-
cord-001734-bbeznd3r	170	26	as	as	IN
cord-001734-bbeznd3r	170	27	we	-PRON-	PRP
cord-001734-bbeznd3r	170	28	previously	previously	RB
cord-001734-bbeznd3r	170	29	described	describe	VBD
cord-001734-bbeznd3r	170	30	[	[	-LRB-
cord-001734-bbeznd3r	170	31	18	18	CD
cord-001734-bbeznd3r	170	32	]	]	-RRB-
cord-001734-bbeznd3r	170	33	.	.	.
cord-001734-bbeznd3r	171	1	Fig	Fig	NNP
cord-001734-bbeznd3r	171	2	2B	2b	CD
cord-001734-bbeznd3r	171	3	shows	show	VBZ
cord-001734-bbeznd3r	171	4	the	the	DT
cord-001734-bbeznd3r	171	5	intensity	intensity	NN
cord-001734-bbeznd3r	171	6	ratios	ratio	NNS
cord-001734-bbeznd3r	171	7	of	of	IN
cord-001734-bbeznd3r	171	8	HSQC	HSQC	NNP
cord-001734-bbeznd3r	171	9	peaks	peak	NNS
cord-001734-bbeznd3r	171	10	from	from	IN
cord-001734-bbeznd3r	171	11	the	the	DT
cord-001734-bbeznd3r	171	12	oxidized	oxidize	VBN
cord-001734-bbeznd3r	171	13	(	(	-LRB-
cord-001734-bbeznd3r	171	14	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	171	15	)	)	-RRB-
cord-001734-bbeznd3r	171	16	and	and	CC
cord-001734-bbeznd3r	171	17	reduced	reduce	VBN
cord-001734-bbeznd3r	171	18	(	(	-LRB-
cord-001734-bbeznd3r	171	19	diamagnetic	diamagnetic	JJ
cord-001734-bbeznd3r	171	20	)	)	-RRB-
cord-001734-bbeznd3r	171	21	spectra	spectrum	NNS
cord-001734-bbeznd3r	171	22	of	of	IN
cord-001734-bbeznd3r	171	23	Q27C	Q27C	NNP
cord-001734-bbeznd3r	171	24	mutant	mutant	JJ
cord-001734-bbeznd3r	171	25	.	.	.
cord-001734-bbeznd3r	172	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	172	2	,	,	,
cord-001734-bbeznd3r	172	3	the	the	DT
cord-001734-bbeznd3r	172	4	residues	residue	NNS
cord-001734-bbeznd3r	172	5	which	which	WDT
cord-001734-bbeznd3r	172	6	were	be	VBD
cord-001734-bbeznd3r	172	7	significant	significant	JJ
cord-001734-bbeznd3r	172	8	affected	affect	VBN
cord-001734-bbeznd3r	172	9	(	(	-LRB-
cord-001734-bbeznd3r	172	10	ratio	ratio	NN
cord-001734-bbeznd3r	172	11	<	<	XX
cord-001734-bbeznd3r	172	12	0.85	0.85	CD
cord-001734-bbeznd3r	172	13	)	)	-RRB-
cord-001734-bbeznd3r	172	14	are	be	VBP
cord-001734-bbeznd3r	172	15	all	all	DT
cord-001734-bbeznd3r	172	16	located	locate	VBN
cord-001734-bbeznd3r	172	17	in	in	IN
cord-001734-bbeznd3r	172	18	the	the	DT
cord-001734-bbeznd3r	172	19	first	first	JJ
cord-001734-bbeznd3r	172	20	β	β	NN
cord-001734-bbeznd3r	172	21	-	-	HYPH
cord-001734-bbeznd3r	172	22	barrel	barrel	NN
cord-001734-bbeznd3r	172	23	of	of	IN
cord-001734-bbeznd3r	172	24	the	the	DT
cord-001734-bbeznd3r	172	25	chymotrypsin	chymotrypsin	NNP
cord-001734-bbeznd3r	172	26	fold	fold	NN
cord-001734-bbeznd3r	172	27	adopted	adopt	VBN
cord-001734-bbeznd3r	172	28	by	by	IN
cord-001734-bbeznd3r	172	29	the	the	DT
cord-001734-bbeznd3r	172	30	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	172	31	domain	domain	NN
cord-001734-bbeznd3r	172	32	in	in	IN
cord-001734-bbeznd3r	172	33	the	the	DT
cord-001734-bbeznd3r	172	34	native	native	JJ
cord-001734-bbeznd3r	172	35	NS2B	NS2B	NNP
cord-001734-bbeznd3r	172	36	-	-	HYPH
cord-001734-bbeznd3r	172	37	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	172	38	complex	complex	NN
cord-001734-bbeznd3r	172	39	(	(	-LRB-
cord-001734-bbeznd3r	172	40	Fig	Fig	NNP
cord-001734-bbeznd3r	172	41	2C	2c	NN
cord-001734-bbeznd3r	172	42	)	)	-RRB-
cord-001734-bbeznd3r	172	43	.	.	.
cord-001734-bbeznd3r	173	1	This	this	DT
cord-001734-bbeznd3r	173	2	suggests	suggest	VBZ
cord-001734-bbeznd3r	173	3	that	that	IN
cord-001734-bbeznd3r	173	4	these	these	DT
cord-001734-bbeznd3r	173	5	affected	affect	VBN
cord-001734-bbeznd3r	173	6	residues	residue	NNS
cord-001734-bbeznd3r	173	7	have	have	VBP
cord-001734-bbeznd3r	173	8	long	long	JJ
cord-001734-bbeznd3r	173	9	-	-	HYPH
cord-001734-bbeznd3r	173	10	range	range	NN
cord-001734-bbeznd3r	173	11	contacts	contact	NNS
cord-001734-bbeznd3r	173	12	with	with	IN
cord-001734-bbeznd3r	173	13	Cys27	Cys27	NNP
cord-001734-bbeznd3r	173	14	with	with	IN
cord-001734-bbeznd3r	173	15	distances	distance	NNS
cord-001734-bbeznd3r	173	16	<	<	XX
cord-001734-bbeznd3r	173	17	25	25	CD
cord-001734-bbeznd3r	173	18	Å.	Å.	NNP
cord-001734-bbeznd3r	174	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	174	2	,	,	,
cord-001734-bbeznd3r	174	3	although	although	IN
cord-001734-bbeznd3r	174	4	residues	residue	NNS
cord-001734-bbeznd3r	174	5	Thr48-Glu66	thr48-glu66	IN
cord-001734-bbeznd3r	174	6	assuming	assume	VBG
cord-001734-bbeznd3r	174	7	a	a	DT
cord-001734-bbeznd3r	174	8	short	short	JJ
cord-001734-bbeznd3r	174	9	helix	helix	NN
cord-001734-bbeznd3r	174	10	and	and	CC
cord-001734-bbeznd3r	174	11	β	β	NN
cord-001734-bbeznd3r	174	12	-	-	HYPH
cord-001734-bbeznd3r	174	13	sheet	sheet	NN
cord-001734-bbeznd3r	174	14	have	have	VBP
cord-001734-bbeznd3r	174	15	very	very	RB
cord-001734-bbeznd3r	174	16	close	close	JJ
cord-001734-bbeznd3r	174	17	contacts	contact	NNS
cord-001734-bbeznd3r	174	18	with	with	IN
cord-001734-bbeznd3r	174	19	Cys27	Cys27	NNP
cord-001734-bbeznd3r	174	20	in	in	IN
cord-001734-bbeznd3r	174	21	the	the	DT
cord-001734-bbeznd3r	174	22	native	native	JJ
cord-001734-bbeznd3r	174	23	structure	structure	NN
cord-001734-bbeznd3r	174	24	,	,	,
cord-001734-bbeznd3r	174	25	they	-PRON-	PRP
cord-001734-bbeznd3r	174	26	were	be	VBD
cord-001734-bbeznd3r	174	27	not	not	RB
cord-001734-bbeznd3r	174	28	significantly	significantly	RB
cord-001734-bbeznd3r	174	29	perturbed	perturb	VBN
cord-001734-bbeznd3r	174	30	by	by	IN
cord-001734-bbeznd3r	174	31	the	the	DT
cord-001734-bbeznd3r	174	32	spin	spin	NN
cord-001734-bbeznd3r	174	33	-	-	HYPH
cord-001734-bbeznd3r	174	34	label	label	NN
cord-001734-bbeznd3r	174	35	at	at	IN
cord-001734-bbeznd3r	174	36	Cys27	Cys27	NNP
cord-001734-bbeznd3r	174	37	.	.	.
cord-001734-bbeznd3r	175	1	This	this	DT
cord-001734-bbeznd3r	175	2	strongly	strongly	RB
cord-001734-bbeznd3r	175	3	implies	imply	VBZ
cord-001734-bbeznd3r	175	4	that	that	IN
cord-001734-bbeznd3r	175	5	the	the	DT
cord-001734-bbeznd3r	175	6	tertiary	tertiary	JJ
cord-001734-bbeznd3r	175	7	packing	packing	NN
cord-001734-bbeznd3r	175	8	is	be	VBZ
cord-001734-bbeznd3r	175	9	non	non	JJ
cord-001734-bbeznd3r	175	10	-	-	JJ
cord-001734-bbeznd3r	175	11	native	native	JJ
cord-001734-bbeznd3r	175	12	in	in	IN
cord-001734-bbeznd3r	175	13	the	the	DT
cord-001734-bbeznd3r	175	14	isolated	isolated	JJ
cord-001734-bbeznd3r	175	15	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	175	16	domain	domain	NN
cord-001734-bbeznd3r	175	17	.	.	.
cord-001734-bbeznd3r	176	1	The	the	DT
cord-001734-bbeznd3r	176	2	spin	spin	NN
cord-001734-bbeznd3r	176	3	-	-	HYPH
cord-001734-bbeznd3r	176	4	label	label	NN
cord-001734-bbeznd3r	176	5	at	at	IN
cord-001734-bbeznd3r	176	6	the	the	DT
cord-001734-bbeznd3r	176	7	position	position	NN
cord-001734-bbeznd3r	176	8	86	86	CD
cord-001734-bbeznd3r	176	9	significantly	significantly	RB
cord-001734-bbeznd3r	176	10	affected	affect	VBD
cord-001734-bbeznd3r	176	11	the	the	DT
cord-001734-bbeznd3r	176	12	residues	residue	NNS
cord-001734-bbeznd3r	176	13	on	on	IN
cord-001734-bbeznd3r	176	14	both	both	CC
cord-001734-bbeznd3r	176	15	β	β	NN
cord-001734-bbeznd3r	176	16	-	-	HYPH
cord-001734-bbeznd3r	176	17	barrels	barrel	NNS
cord-001734-bbeznd3r	176	18	(	(	-LRB-
cord-001734-bbeznd3r	176	19	Fig	Fig	NNP
cord-001734-bbeznd3r	176	20	2D	2d	NN
cord-001734-bbeznd3r	176	21	and	and	CC
cord-001734-bbeznd3r	176	22	2E	2E	NNP
cord-001734-bbeznd3r	176	23	)	)	-RRB-
cord-001734-bbeznd3r	176	24	,	,	,
cord-001734-bbeznd3r	176	25	suggesting	suggest	VBG
cord-001734-bbeznd3r	176	26	that	that	IN
cord-001734-bbeznd3r	176	27	these	these	DT
cord-001734-bbeznd3r	176	28	residues	residue	NNS
cord-001734-bbeznd3r	176	29	have	have	VBP
cord-001734-bbeznd3r	176	30	long	long	JJ
cord-001734-bbeznd3r	176	31	-	-	HYPH
cord-001734-bbeznd3r	176	32	range	range	NN
cord-001734-bbeznd3r	176	33	contacts	contact	NNS
cord-001734-bbeznd3r	176	34	to	to	IN
cord-001734-bbeznd3r	176	35	Cys86	Cys86	NNPS
cord-001734-bbeznd3r	176	36	with	with	IN
cord-001734-bbeznd3r	176	37	distances	distance	NNS
cord-001734-bbeznd3r	176	38	<	<	XX
cord-001734-bbeznd3r	176	39	25	25	CD
cord-001734-bbeznd3r	176	40	Å.	Å.	NNP
cord-001734-bbeznd3r	176	41	Again	again	RB
cord-001734-bbeznd3r	176	42	,	,	,
cord-001734-bbeznd3r	176	43	many	many	JJ
cord-001734-bbeznd3r	176	44	residues	residue	NNS
cord-001734-bbeznd3r	176	45	have	have	VBP
cord-001734-bbeznd3r	176	46	very	very	RB
cord-001734-bbeznd3r	176	47	close	close	JJ
cord-001734-bbeznd3r	176	48	contacts	contact	NNS
cord-001734-bbeznd3r	176	49	with	with	IN
cord-001734-bbeznd3r	176	50	Cys86	Cys86	NNPS
cord-001734-bbeznd3r	176	51	in	in	IN
cord-001734-bbeznd3r	176	52	the	the	DT
cord-001734-bbeznd3r	176	53	native	native	JJ
cord-001734-bbeznd3r	176	54	fold	fold	NN
cord-001734-bbeznd3r	176	55	but	but	CC
cord-001734-bbeznd3r	176	56	were	be	VBD
cord-001734-bbeznd3r	176	57	not	not	RB
cord-001734-bbeznd3r	176	58	significantly	significantly	RB
cord-001734-bbeznd3r	176	59	perturbed	perturb	VBN
cord-001734-bbeznd3r	176	60	by	by	IN
cord-001734-bbeznd3r	176	61	the	the	DT
cord-001734-bbeznd3r	176	62	spin	spin	NN
cord-001734-bbeznd3r	176	63	-	-	HYPH
cord-001734-bbeznd3r	176	64	label	label	NN
cord-001734-bbeznd3r	176	65	at	at	IN
cord-001734-bbeznd3r	176	66	Cys88	Cys88	NNP
cord-001734-bbeznd3r	176	67	.	.	.
cord-001734-bbeznd3r	177	1	The	the	DT
cord-001734-bbeznd3r	177	2	residues	residue	NNS
cord-001734-bbeznd3r	177	3	affected	affect	VBN
cord-001734-bbeznd3r	177	4	by	by	IN
cord-001734-bbeznd3r	177	5	the	the	DT
cord-001734-bbeznd3r	177	6	spin	spin	NN
cord-001734-bbeznd3r	177	7	-	-	HYPH
cord-001734-bbeznd3r	177	8	label	label	NN
cord-001734-bbeznd3r	177	9	at	at	IN
cord-001734-bbeznd3r	177	10	the	the	DT
cord-001734-bbeznd3r	177	11	position	position	NN
cord-001734-bbeznd3r	177	12	158	158	CD
cord-001734-bbeznd3r	177	13	are	be	VBP
cord-001734-bbeznd3r	177	14	mostly	mostly	RB
cord-001734-bbeznd3r	177	15	located	locate	VBN
cord-001734-bbeznd3r	177	16	on	on	IN
cord-001734-bbeznd3r	177	17	second	second	JJ
cord-001734-bbeznd3r	177	18	β	β	NN
cord-001734-bbeznd3r	177	19	-	-	HYPH
cord-001734-bbeznd3r	177	20	barrel	barrel	NN
cord-001734-bbeznd3r	177	21	,	,	,
cord-001734-bbeznd3r	177	22	the	the	DT
cord-001734-bbeznd3r	177	23	loop	loop	NN
cord-001734-bbeznd3r	177	24	connecting	connect	VBG
cord-001734-bbeznd3r	177	25	two	two	CD
cord-001734-bbeznd3r	177	26	βbarrels	βbarrel	NNS
cord-001734-bbeznd3r	177	27	,	,	,
cord-001734-bbeznd3r	177	28	and	and	CC
cord-001734-bbeznd3r	177	29	the	the	DT
cord-001734-bbeznd3r	177	30	last	last	JJ
cord-001734-bbeznd3r	177	31	β	β	NN
cord-001734-bbeznd3r	177	32	-	-	HYPH
cord-001734-bbeznd3r	177	33	sheet	sheet	NN
cord-001734-bbeznd3r	177	34	over	over	IN
cord-001734-bbeznd3r	177	35	residues	residue	NNS
cord-001734-bbeznd3r	177	36	Ser68-Gly71	ser68-gly71	NN
cord-001734-bbeznd3r	178	1	(	(	-LRB-
cord-001734-bbeznd3r	178	2	Fig	Fig	NNP
cord-001734-bbeznd3r	178	3	2F	2F	NNP
cord-001734-bbeznd3r	178	4	and	and	CC
cord-001734-bbeznd3r	178	5	2	2	CD
cord-001734-bbeznd3r	178	6	G	G	NNP
cord-001734-bbeznd3r	178	7	)	)	-RRB-
cord-001734-bbeznd3r	178	8	.	.	.
cord-001734-bbeznd3r	179	1	The	the	DT
cord-001734-bbeznd3r	179	2	PRE	pre	JJ
cord-001734-bbeznd3r	179	3	measurements	measurement	NNS
cord-001734-bbeznd3r	179	4	revealed	reveal	VBD
cord-001734-bbeznd3r	179	5	that	that	IN
cord-001734-bbeznd3r	179	6	despite	despite	IN
cord-001734-bbeznd3r	179	7	lacking	lack	VBG
cord-001734-bbeznd3r	179	8	of	of	IN
cord-001734-bbeznd3r	179	9	stable	stable	JJ
cord-001734-bbeznd3r	179	10	secondary	secondary	JJ
cord-001734-bbeznd3r	179	11	and	and	CC
cord-001734-bbeznd3r	179	12	tight	tight	JJ
cord-001734-bbeznd3r	179	13	tertiary	tertiary	JJ
cord-001734-bbeznd3r	179	14	structures	structure	NNS
cord-001734-bbeznd3r	179	15	,	,	,
cord-001734-bbeznd3r	179	16	the	the	DT
cord-001734-bbeznd3r	179	17	isolated	isolated	JJ
cord-001734-bbeznd3r	179	18	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	179	19	domain	domain	NN
cord-001734-bbeznd3r	179	20	is	be	VBZ
cord-001734-bbeznd3r	179	21	not	not	RB
cord-001734-bbeznd3r	179	22	completely	completely	RB
cord-001734-bbeznd3r	179	23	extended	extend	VBN
cord-001734-bbeznd3r	179	24	,	,	,
cord-001734-bbeznd3r	179	25	but	but	CC
cord-001734-bbeznd3r	179	26	instead	instead	RB
cord-001734-bbeznd3r	179	27	has	have	VBZ
cord-001734-bbeznd3r	179	28	a	a	DT
cord-001734-bbeznd3r	179	29	loose	loose	JJ
cord-001734-bbeznd3r	179	30	tertiary	tertiary	JJ
cord-001734-bbeznd3r	179	31	packing	packing	NN
cord-001734-bbeznd3r	179	32	.	.	.
cord-001734-bbeznd3r	180	1	However	however	RB
cord-001734-bbeznd3r	180	2	,	,	,
cord-001734-bbeznd3r	180	3	this	this	DT
cord-001734-bbeznd3r	180	4	packing	packing	NN
cord-001734-bbeznd3r	180	5	is	be	VBZ
cord-001734-bbeznd3r	180	6	highly	highly	RB
cord-001734-bbeznd3r	180	7	dynamic	dynamic	JJ
cord-001734-bbeznd3r	180	8	and	and	CC
cord-001734-bbeznd3r	180	9	non	non	JJ
cord-001734-bbeznd3r	180	10	-	-	JJ
cord-001734-bbeznd3r	180	11	native	native	JJ
cord-001734-bbeznd3r	180	12	,	,	,
cord-001734-bbeznd3r	180	13	in	in	IN
cord-001734-bbeznd3r	180	14	which	which	WDT
cord-001734-bbeznd3r	180	15	the	the	DT
cord-001734-bbeznd3r	180	16	residues	residue	NNS
cord-001734-bbeznd3r	180	17	over	over	IN
cord-001734-bbeznd3r	180	18	the	the	DT
cord-001734-bbeznd3r	180	19	middle	middle	JJ
cord-001734-bbeznd3r	180	20	region	region	NN
cord-001734-bbeznd3r	180	21	of	of	IN
cord-001734-bbeznd3r	180	22	the	the	DT
cord-001734-bbeznd3r	180	23	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	180	24	sequence	sequence	NN
cord-001734-bbeznd3r	180	25	are	be	VBP
cord-001734-bbeznd3r	180	26	slightly	slightly	RB
cord-001734-bbeznd3r	180	27	less	less	RBR
cord-001734-bbeznd3r	180	28	dynamic	dynamic	JJ
cord-001734-bbeznd3r	180	29	than	than	IN
cord-001734-bbeznd3r	180	30	the	the	DT
cord-001734-bbeznd3r	180	31	N	N	NNP
cord-001734-bbeznd3r	180	32	-	-	HYPH
cord-001734-bbeznd3r	180	33	and	and	CC
cord-001734-bbeznd3r	180	34	C	c	NN
cord-001734-bbeznd3r	180	35	-	-	HYPH
cord-001734-bbeznd3r	180	36	terminal	terminal	NN
cord-001734-bbeznd3r	180	37	ones	one	NNS
cord-001734-bbeznd3r	180	38	,	,	,
cord-001734-bbeznd3r	180	39	completely	completely	RB
cord-001734-bbeznd3r	180	40	consistent	consistent	JJ
cord-001734-bbeznd3r	180	41	with	with	IN
cord-001734-bbeznd3r	180	42	hNOE	hnoe	NN
cord-001734-bbeznd3r	180	43	results	result	NNS
cord-001734-bbeznd3r	180	44	(	(	-LRB-
cord-001734-bbeznd3r	180	45	Fig	Fig	NNP
cord-001734-bbeznd3r	180	46	2A	2a	CD
cord-001734-bbeznd3r	180	47	)	)	-RRB-
cord-001734-bbeznd3r	180	48	.	.	.
cord-001734-bbeznd3r	181	1	The	the	DT
cord-001734-bbeznd3r	181	2	isolated	isolated	JJ
cord-001734-bbeznd3r	181	3	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	181	4	(	(	-LRB-
cord-001734-bbeznd3r	181	5	14	14	CD
cord-001734-bbeznd3r	181	6	-	-	SYM
cord-001734-bbeznd3r	181	7	185	185	CD
cord-001734-bbeznd3r	181	8	)	)	-RRB-
cord-001734-bbeznd3r	181	9	and	and	CC
cord-001734-bbeznd3r	181	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	181	11	(	(	-LRB-
cord-001734-bbeznd3r	181	12	48	48	CD
cord-001734-bbeznd3r	181	13	-	-	SYM
cord-001734-bbeznd3r	181	14	100	100	CD
cord-001734-bbeznd3r	181	15	)	)	-RRB-
cord-001734-bbeznd3r	181	16	are	be	VBP
cord-001734-bbeznd3r	181	17	largely	largely	RB
cord-001734-bbeznd3r	181	18	disordered	disordered	JJ
cord-001734-bbeznd3r	181	19	in	in	IN
cord-001734-bbeznd3r	181	20	solution	solution	NN
cord-001734-bbeznd3r	181	21	(	(	-LRB-
cord-001734-bbeznd3r	181	22	Fig	Fig	NNP
cord-001734-bbeznd3r	181	23	3A	3a	CD
cord-001734-bbeznd3r	181	24	)	)	-RRB-
cord-001734-bbeznd3r	181	25	and	and	CC
cord-001734-bbeznd3r	181	26	the	the	DT
cord-001734-bbeznd3r	181	27	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	181	28	alone	alone	RB
cord-001734-bbeznd3r	181	29	showed	show	VBD
cord-001734-bbeznd3r	181	30	no	no	DT
cord-001734-bbeznd3r	181	31	detectable	detectable	JJ
cord-001734-bbeznd3r	181	32	catalytic	catalytic	JJ
cord-001734-bbeznd3r	181	33	activity	activity	NN
cord-001734-bbeznd3r	181	34	even	even	RB
cord-001734-bbeznd3r	181	35	with	with	IN
cord-001734-bbeznd3r	181	36	a	a	DT
cord-001734-bbeznd3r	181	37	protease	protease	NN
cord-001734-bbeznd3r	181	38	concentration	concentration	NN
cord-001734-bbeznd3r	181	39	up	up	IN
cord-001734-bbeznd3r	181	40	to	to	IN
cord-001734-bbeznd3r	181	41	5	5	CD
cord-001734-bbeznd3r	181	42	μM	μM	NNS
cord-001734-bbeznd3r	181	43	in	in	IN
cord-001734-bbeznd3r	181	44	buffers	buffer	NNS
cord-001734-bbeznd3r	181	45	at	at	IN
cord-001734-bbeznd3r	181	46	pH	pH	NNP
cord-001734-bbeznd3r	181	47	7.5	7.5	CD
cord-001734-bbeznd3r	182	1	(	(	-LRB-
cord-001734-bbeznd3r	182	2	Fig	Fig	NNP
cord-001734-bbeznd3r	182	3	3B	3b	CD
cord-001734-bbeznd3r	182	4	)	)	-RRB-
cord-001734-bbeznd3r	182	5	.	.	.
cord-001734-bbeznd3r	183	1	However	however	RB
cord-001734-bbeznd3r	183	2	,	,	,
cord-001734-bbeznd3r	183	3	upon	upon	IN
cord-001734-bbeznd3r	183	4	mixing	mix	VBG
cord-001734-bbeznd3r	183	5	them	-PRON-	PRP
cord-001734-bbeznd3r	183	6	at	at	IN
cord-001734-bbeznd3r	183	7	an	an	DT
cord-001734-bbeznd3r	183	8	equal	equal	JJ
cord-001734-bbeznd3r	183	9	molar	molar	JJ
cord-001734-bbeznd3r	183	10	ratio	ratio	NN
cord-001734-bbeznd3r	183	11	in	in	IN
cord-001734-bbeznd3r	183	12	Milli	Milli	NNP
cord-001734-bbeznd3r	183	13	-	-	HYPH
cord-001734-bbeznd3r	183	14	Q	Q	NNP
cord-001734-bbeznd3r	183	15	water	water	NN
cord-001734-bbeznd3r	183	16	at	at	IN
cord-001734-bbeznd3r	183	17	pH	pH	NNP
cord-001734-bbeznd3r	183	18	4.0	4.0	CD
cord-001734-bbeznd3r	183	19	,	,	,
cord-001734-bbeznd3r	183	20	the	the	DT
cord-001734-bbeznd3r	183	21	mixture	mixture	NN
cord-001734-bbeznd3r	183	22	has	have	VBZ
cord-001734-bbeznd3r	183	23	a	a	DT
cord-001734-bbeznd3r	183	24	CD	cd	NN
cord-001734-bbeznd3r	183	25	spectrum	spectrum	NN
cord-001734-bbeznd3r	183	26	for	for	IN
cord-001734-bbeznd3r	183	27	a	a	DT
cord-001734-bbeznd3r	183	28	protein	protein	NN
cord-001734-bbeznd3r	183	29	with	with	IN
cord-001734-bbeznd3r	183	30	a	a	DT
cord-001734-bbeznd3r	183	31	substantial	substantial	JJ
cord-001734-bbeznd3r	183	32	amount	amount	NN
cord-001734-bbeznd3r	183	33	of	of	IN
cord-001734-bbeznd3r	183	34	secondary	secondary	JJ
cord-001734-bbeznd3r	183	35	structures	structure	NNS
cord-001734-bbeznd3r	183	36	,	,	,
cord-001734-bbeznd3r	183	37	which	which	WDT
cord-001734-bbeznd3r	183	38	has	have	VBZ
cord-001734-bbeznd3r	183	39	a	a	DT
cord-001734-bbeznd3r	183	40	large	large	JJ
cord-001734-bbeznd3r	183	41	positive	positive	JJ
cord-001734-bbeznd3r	183	42	signal	signal	NN
cord-001734-bbeznd3r	183	43	at	at	IN
cord-001734-bbeznd3r	183	44	190	190	CD
cord-001734-bbeznd3r	183	45	nm	nm	NN
cord-001734-bbeznd3r	183	46	and	and	CC
cord-001734-bbeznd3r	183	47	the	the	DT
cord-001734-bbeznd3r	183	48	maximal	maximal	JJ
cord-001734-bbeznd3r	183	49	negative	negative	JJ
cord-001734-bbeznd3r	183	50	signal	signal	NN
cord-001734-bbeznd3r	183	51	at	at	IN
cord-001734-bbeznd3r	183	52	208	208	CD
cord-001734-bbeznd3r	183	53	nm	nm	NN
cord-001734-bbeznd3r	183	54	(	(	-LRB-
cord-001734-bbeznd3r	183	55	Fig	Fig	NNP
cord-001734-bbeznd3r	183	56	3A	3a	CD
cord-001734-bbeznd3r	183	57	)	)	-RRB-
cord-001734-bbeznd3r	183	58	.	.	.
cord-001734-bbeznd3r	184	1	The	the	DT
cord-001734-bbeznd3r	184	2	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	184	3	shows	show	VBZ
cord-001734-bbeznd3r	184	4	that	that	IN
cord-001734-bbeznd3r	184	5	this	this	DT
cord-001734-bbeznd3r	184	6	refolded	refolde	VBD
cord-001734-bbeznd3r	184	7	complex	complex	NN
cord-001734-bbeznd3r	184	8	between	between	IN
cord-001734-bbeznd3r	184	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	184	10	(	(	-LRB-
cord-001734-bbeznd3r	184	11	48	48	CD
cord-001734-bbeznd3r	184	12	-	-	SYM
cord-001734-bbeznd3r	184	13	100	100	CD
cord-001734-bbeznd3r	184	14	)	)	-RRB-
cord-001734-bbeznd3r	184	15	and	and	CC
cord-001734-bbeznd3r	184	16	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	184	17	in	in	IN
cord-001734-bbeznd3r	184	18	water	water	NN
cord-001734-bbeznd3r	184	19	at	at	IN
cord-001734-bbeznd3r	184	20	pH	pH	NNP
cord-001734-bbeznd3r	184	21	4.0	4.0	CD
cord-001734-bbeznd3r	184	22	contains	contain	VBZ
cord-001734-bbeznd3r	184	23	a	a	DT
cord-001734-bbeznd3r	184	24	large	large	JJ
cord-001734-bbeznd3r	184	25	portion	portion	NN
cord-001734-bbeznd3r	184	26	of	of	IN
cord-001734-bbeznd3r	184	27	β	β	NN
cord-001734-bbeznd3r	184	28	-	-	HYPH
cord-001734-bbeznd3r	184	29	strand	strand	NN
cord-001734-bbeznd3r	184	30	and	and	CC
cord-001734-bbeznd3r	184	31	βturn	βturn	NN
cord-001734-bbeznd3r	184	32	structures	structure	NNS
cord-001734-bbeznd3r	184	33	:	:	:
cord-001734-bbeznd3r	184	34	34	34	CD
cord-001734-bbeznd3r	184	35	%	%	NN
cord-001734-bbeznd3r	184	36	random	random	JJ
cord-001734-bbeznd3r	184	37	coil	coil	NN
cord-001734-bbeznd3r	184	38	,	,	,
cord-001734-bbeznd3r	184	39	22	22	CD
cord-001734-bbeznd3r	184	40	%	%	NN
cord-001734-bbeznd3r	184	41	turn	turn	NN
cord-001734-bbeznd3r	184	42	,	,	,
cord-001734-bbeznd3r	184	43	37	37	CD
cord-001734-bbeznd3r	184	44	%	%	NN
cord-001734-bbeznd3r	184	45	extended	extended	JJ
cord-001734-bbeznd3r	184	46	strand	strand	NN
cord-001734-bbeznd3r	184	47	and	and	CC
cord-001734-bbeznd3r	184	48	7	7	CD
cord-001734-bbeznd3r	184	49	%	%	NN
cord-001734-bbeznd3r	184	50	helix	helix	NN
cord-001734-bbeznd3r	184	51	secondary	secondary	JJ
cord-001734-bbeznd3r	184	52	structures	structure	NNS
cord-001734-bbeznd3r	184	53	,	,	,
cord-001734-bbeznd3r	184	54	which	which	WDT
cord-001734-bbeznd3r	184	55	is	be	VBZ
cord-001734-bbeznd3r	184	56	consistent	consistent	JJ
cord-001734-bbeznd3r	184	57	with	with	IN
cord-001734-bbeznd3r	184	58	its	-PRON-	PRP$
cord-001734-bbeznd3r	184	59	three	three	CD
cord-001734-bbeznd3r	184	60	-	-	HYPH
cord-001734-bbeznd3r	184	61	dimensional	dimensional	JJ
cord-001734-bbeznd3r	184	62	structure	structure	NN
cord-001734-bbeznd3r	184	63	(	(	-LRB-
cord-001734-bbeznd3r	184	64	Fig	Fig	NNP
cord-001734-bbeznd3r	184	65	2	2	CD
cord-001734-bbeznd3r	184	66	)	)	-RRB-
cord-001734-bbeznd3r	184	67	.	.	.
cord-001734-bbeznd3r	185	1	This	this	DT
cord-001734-bbeznd3r	185	2	sample	sample	NN
cord-001734-bbeznd3r	185	3	was	be	VBD
cord-001734-bbeznd3r	185	4	subsequently	subsequently	RB
cord-001734-bbeznd3r	185	5	split	split	VBN
cord-001734-bbeznd3r	185	6	into	into	IN
cord-001734-bbeznd3r	185	7	two	two	CD
cord-001734-bbeznd3r	185	8	:	:	:
cord-001734-bbeznd3r	185	9	one	one	CD
cord-001734-bbeznd3r	185	10	at	at	IN
cord-001734-bbeznd3r	185	11	the	the	DT
cord-001734-bbeznd3r	185	12	same	same	JJ
cord-001734-bbeznd3r	185	13	condition	condition	NN
cord-001734-bbeznd3r	185	14	at	at	IN
cord-001734-bbeznd3r	185	15	pH	pH	NNP
cord-001734-bbeznd3r	185	16	4.0	4.0	CD
cord-001734-bbeznd3r	185	17	,	,	,
cord-001734-bbeznd3r	185	18	and	and	CC
cord-001734-bbeznd3r	185	19	another	another	DT
cord-001734-bbeznd3r	185	20	with	with	IN
cord-001734-bbeznd3r	185	21	buffer	buffer	NN
cord-001734-bbeznd3r	185	22	added	add	VBN
cord-001734-bbeznd3r	185	23	to	to	TO
cord-001734-bbeznd3r	185	24	reach	reach	VB
cord-001734-bbeznd3r	185	25	pH	pH	NNP
cord-001734-bbeznd3r	185	26	7.5	7.5	CD
cord-001734-bbeznd3r	185	27	.	.	.
cord-001734-bbeznd3r	186	1	As	as	IN
cord-001734-bbeznd3r	186	2	shown	show	VBN
cord-001734-bbeznd3r	186	3	in	in	IN
cord-001734-bbeznd3r	186	4	Fig	Fig	NNP
cord-001734-bbeznd3r	186	5	3A	3a	CD
cord-001734-bbeznd3r	186	6	,	,	,
cord-001734-bbeznd3r	186	7	the	the	DT
cord-001734-bbeznd3r	186	8	CD	CD	NNP
cord-001734-bbeznd3r	186	9	spectrum	spectrum	NN
cord-001734-bbeznd3r	186	10	of	of	IN
cord-001734-bbeznd3r	186	11	the	the	DT
cord-001734-bbeznd3r	186	12	mixture	mixture	NN
cord-001734-bbeznd3r	186	13	in	in	IN
cord-001734-bbeznd3r	186	14	buffer	buffer	NN
cord-001734-bbeznd3r	186	15	at	at	IN
cord-001734-bbeznd3r	186	16	pH	pH	NNP
cord-001734-bbeznd3r	186	17	7.5	7.5	CD
cord-001734-bbeznd3r	186	18	has	have	VBZ
cord-001734-bbeznd3r	186	19	slight	slight	JJ
cord-001734-bbeznd3r	186	20	changes	change	NNS
cord-001734-bbeznd3r	186	21	:	:	:
cord-001734-bbeznd3r	186	22	the	the	DT
cord-001734-bbeznd3r	186	23	maximal	maximal	JJ
cord-001734-bbeznd3r	186	24	positive	positive	JJ
cord-001734-bbeznd3r	186	25	signal	signal	NN
cord-001734-bbeznd3r	186	26	shifted	shift	VBD
cord-001734-bbeznd3r	186	27	to	to	IN
cord-001734-bbeznd3r	186	28	192	192	CD
cord-001734-bbeznd3r	186	29	nm	nm	NN
cord-001734-bbeznd3r	186	30	as	as	RB
cord-001734-bbeznd3r	186	31	well	well	RB
cord-001734-bbeznd3r	186	32	as	as	IN
cord-001734-bbeznd3r	186	33	became	become	VBD
cord-001734-bbeznd3r	186	34	larger	large	JJR
cord-001734-bbeznd3r	186	35	;	;	:
cord-001734-bbeznd3r	186	36	and	and	CC
cord-001734-bbeznd3r	186	37	the	the	DT
cord-001734-bbeznd3r	186	38	maximal	maximal	JJ
cord-001734-bbeznd3r	186	39	negative	negative	JJ
cord-001734-bbeznd3r	186	40	signal	signal	NN
cord-001734-bbeznd3r	186	41	shifted	shift	VBD
cord-001734-bbeznd3r	186	42	from	from	IN
cord-001734-bbeznd3r	186	43	208	208	CD
cord-001734-bbeznd3r	186	44	to	to	IN
cord-001734-bbeznd3r	186	45	217	217	CD
cord-001734-bbeznd3r	186	46	nm	nm	NN
cord-001734-bbeznd3r	186	47	,	,	,
cord-001734-bbeznd3r	186	48	almost	almost	RB
cord-001734-bbeznd3r	186	49	identical	identical	JJ
cord-001734-bbeznd3r	186	50	to	to	IN
cord-001734-bbeznd3r	186	51	that	that	DT
cord-001734-bbeznd3r	186	52	previously	previously	RB
cord-001734-bbeznd3r	186	53	reported	report	VBN
cord-001734-bbeznd3r	186	54	on	on	IN
cord-001734-bbeznd3r	186	55	the	the	DT
cord-001734-bbeznd3r	186	56	co	co	NN
cord-001734-bbeznd3r	186	57	-	-	VBN
cord-001734-bbeznd3r	186	58	expressed	express	VBN
cord-001734-bbeznd3r	186	59	NS2B	NS2B	NNP
cord-001734-bbeznd3r	186	60	-	-	HYPH
cord-001734-bbeznd3r	186	61	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	186	62	complex	complex	NN
cord-001734-bbeznd3r	186	63	[	[	-LRB-
cord-001734-bbeznd3r	186	64	10	10	CD
cord-001734-bbeznd3r	186	65	]	]	-RRB-
cord-001734-bbeznd3r	186	66	.	.	.
cord-001734-bbeznd3r	187	1	This	this	DT
cord-001734-bbeznd3r	187	2	change	change	NN
cord-001734-bbeznd3r	187	3	appears	appear	VBZ
cord-001734-bbeznd3r	187	4	to	to	TO
cord-001734-bbeznd3r	187	5	result	result	VB
cord-001734-bbeznd3r	187	6	from	from	IN
cord-001734-bbeznd3r	187	7	the	the	DT
cord-001734-bbeznd3r	187	8	slight	slight	JJ
cord-001734-bbeznd3r	187	9	increase	increase	NN
cord-001734-bbeznd3r	187	10	of	of	IN
cord-001734-bbeznd3r	187	11	β	β	NN
cord-001734-bbeznd3r	187	12	-	-	HYPH
cord-001734-bbeznd3r	187	13	strand	strand	NN
cord-001734-bbeznd3r	187	14	and	and	CC
cord-001734-bbeznd3r	187	15	reduction	reduction	NN
cord-001734-bbeznd3r	187	16	of	of	IN
cord-001734-bbeznd3r	187	17	random	random	JJ
cord-001734-bbeznd3r	187	18	coil	coil	NN
cord-001734-bbeznd3r	187	19	conformations	conformation	NNS
cord-001734-bbeznd3r	187	20	.	.	.
cord-001734-bbeznd3r	188	1	The	the	DT
cord-001734-bbeznd3r	188	2	slight	slight	JJ
cord-001734-bbeznd3r	188	3	variations	variation	NNS
cord-001734-bbeznd3r	188	4	in	in	IN
cord-001734-bbeznd3r	188	5	CD	cd	NN
cord-001734-bbeznd3r	188	6	spectra	spectrum	NNS
cord-001734-bbeznd3r	188	7	of	of	IN
cord-001734-bbeznd3r	188	8	the	the	DT
cord-001734-bbeznd3r	188	9	refolded	refolde	VBN
cord-001734-bbeznd3r	188	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	188	11	-	-	HYPH
cord-001734-bbeznd3r	188	12	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	188	13	complex	complex	NN
cord-001734-bbeznd3r	188	14	at	at	IN
cord-001734-bbeznd3r	188	15	pH	pH	NNP
cord-001734-bbeznd3r	188	16	4.0	4.0	CD
cord-001734-bbeznd3r	188	17	and	and	CC
cord-001734-bbeznd3r	188	18	7.5	7.5	CD
cord-001734-bbeznd3r	188	19	suggest	suggest	VBP
cord-001734-bbeznd3r	188	20	that	that	IN
cord-001734-bbeznd3r	188	21	the	the	DT
cord-001734-bbeznd3r	188	22	complex	complex	NN
cord-001734-bbeznd3r	188	23	may	may	MD
cord-001734-bbeznd3r	188	24	have	have	VB
cord-001734-bbeznd3r	188	25	some	some	DT
cord-001734-bbeznd3r	188	26	conformational	conformational	JJ
cord-001734-bbeznd3r	188	27	differences	difference	NNS
cord-001734-bbeznd3r	188	28	at	at	IN
cord-001734-bbeznd3r	188	29	two	two	CD
cord-001734-bbeznd3r	188	30	pH	ph	NN
cord-001734-bbeznd3r	188	31	values	value	NNS
cord-001734-bbeznd3r	188	32	.	.	.
cord-001734-bbeznd3r	189	1	Indeed	indeed	RB
cord-001734-bbeznd3r	189	2	,	,	,
cord-001734-bbeznd3r	189	3	the	the	DT
cord-001734-bbeznd3r	189	4	complex	complex	NN
cord-001734-bbeznd3r	189	5	at	at	IN
cord-001734-bbeznd3r	189	6	pH	pH	NNP
cord-001734-bbeznd3r	189	7	4.0	4.0	CD
cord-001734-bbeznd3r	189	8	has	have	VBZ
cord-001734-bbeznd3r	189	9	a	a	DT
cord-001734-bbeznd3r	189	10	HSQC	HSQC	NNP
cord-001734-bbeznd3r	189	11	spectrum	spectrum	NN
cord-001734-bbeznd3r	189	12	with	with	IN
cord-001734-bbeznd3r	189	13	many	many	JJ
cord-001734-bbeznd3r	189	14	HSQC	HSQC	NNP
cord-001734-bbeznd3r	189	15	peaks	peak	NNS
cord-001734-bbeznd3r	189	16	too	too	RB
cord-001734-bbeznd3r	189	17	broad	broad	JJ
cord-001734-bbeznd3r	189	18	to	to	TO
cord-001734-bbeznd3r	189	19	be	be	VB
cord-001734-bbeznd3r	189	20	detected	detect	VBN
cord-001734-bbeznd3r	190	1	(	(	-LRB-
cord-001734-bbeznd3r	190	2	Fig	Fig	NNP
cord-001734-bbeznd3r	190	3	3C	3C	NNP
cord-001734-bbeznd3r	190	4	)	)	-RRB-
cord-001734-bbeznd3r	190	5	,	,	,
cord-001734-bbeznd3r	190	6	indicating	indicate	VBG
cord-001734-bbeznd3r	190	7	that	that	IN
cord-001734-bbeznd3r	190	8	the	the	DT
cord-001734-bbeznd3r	190	9	complex	complex	NN
cord-001734-bbeznd3r	190	10	undergoes	undergo	VBZ
cord-001734-bbeznd3r	190	11	significant	significant	JJ
cord-001734-bbeznd3r	190	12	dynamic	dynamic	JJ
cord-001734-bbeznd3r	190	13	aggregation	aggregation	NN
cord-001734-bbeznd3r	190	14	,	,	,
cord-001734-bbeznd3r	190	15	or	or	CC
cord-001734-bbeznd3r	190	16	/	/	SYM
cord-001734-bbeznd3r	190	17	and	and	CC
cord-001734-bbeznd3r	190	18	conformational	conformational	JJ
cord-001734-bbeznd3r	190	19	exchanges	exchange	NNS
cord-001734-bbeznd3r	190	20	on	on	IN
cord-001734-bbeznd3r	190	21	the	the	DT
cord-001734-bbeznd3r	190	22	μs	μs	NNP
cord-001734-bbeznd3r	190	23	-	-	HYPH
cord-001734-bbeznd3r	190	24	ms	ms	NNP
cord-001734-bbeznd3r	190	25	time	time	NN
cord-001734-bbeznd3r	190	26	scale	scale	NN
cord-001734-bbeznd3r	190	27	.	.	.
cord-001734-bbeznd3r	191	1	By	by	IN
cord-001734-bbeznd3r	191	2	contrast	contrast	NN
cord-001734-bbeznd3r	191	3	,	,	,
cord-001734-bbeznd3r	191	4	the	the	DT
cord-001734-bbeznd3r	191	5	refolded	refolde	VBN
cord-001734-bbeznd3r	191	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	191	7	-	-	HYPH
cord-001734-bbeznd3r	191	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	191	9	complex	complex	NN
cord-001734-bbeznd3r	191	10	at	at	IN
cord-001734-bbeznd3r	191	11	pH	pH	NNP
cord-001734-bbeznd3r	191	12	7.5	7.5	CD
cord-001734-bbeznd3r	191	13	has	have	VBZ
cord-001734-bbeznd3r	191	14	a	a	DT
cord-001734-bbeznd3r	191	15	HSQC	HSQC	NNP
cord-001734-bbeznd3r	191	16	spectrum	spectrum	NN
cord-001734-bbeznd3r	191	17	typical	typical	NN
cord-001734-bbeznd3r	191	18	of	of	IN
cord-001734-bbeznd3r	191	19	a	a	DT
cord-001734-bbeznd3r	191	20	well	well	RB
cord-001734-bbeznd3r	191	21	-	-	HYPH
cord-001734-bbeznd3r	191	22	folded	fold	VBN
cord-001734-bbeznd3r	191	23	protein	protein	NN
cord-001734-bbeznd3r	191	24	,	,	,
cord-001734-bbeznd3r	191	25	which	which	WDT
cord-001734-bbeznd3r	191	26	has	have	VBZ
cord-001734-bbeznd3r	191	27	very	very	RB
cord-001734-bbeznd3r	191	28	large	large	JJ
cord-001734-bbeznd3r	191	29	spectral	spectral	JJ
cord-001734-bbeznd3r	191	30	dispersions	dispersion	NNS
cord-001734-bbeznd3r	191	31	at	at	IN
cord-001734-bbeznd3r	191	32	both	both	DT
cord-001734-bbeznd3r	191	33	1	1	CD
cord-001734-bbeznd3r	191	34	H	h	NN
cord-001734-bbeznd3r	191	35	(	(	-LRB-
cord-001734-bbeznd3r	191	36	~3.6	~3.6	CD
cord-001734-bbeznd3r	191	37	ppm	ppm	NN
cord-001734-bbeznd3r	191	38	)	)	-RRB-
cord-001734-bbeznd3r	191	39	and	and	CC
cord-001734-bbeznd3r	191	40	15	15	CD
cord-001734-bbeznd3r	191	41	N	n	CD
cord-001734-bbeznd3r	191	42	(	(	-LRB-
cord-001734-bbeznd3r	191	43	~28	~28	NFP
cord-001734-bbeznd3r	191	44	ppm	ppm	NN
cord-001734-bbeznd3r	191	45	)	)	-RRB-
cord-001734-bbeznd3r	191	46	dimensions	dimension	NNS
cord-001734-bbeznd3r	191	47	(	(	-LRB-
cord-001734-bbeznd3r	191	48	Fig	Fig	NNP
cord-001734-bbeznd3r	191	49	3D	3d	NN
cord-001734-bbeznd3r	191	50	)	)	-RRB-
cord-001734-bbeznd3r	191	51	.	.	.
cord-001734-bbeznd3r	192	1	In	in	IN
cord-001734-bbeznd3r	192	2	particular	particular	JJ
cord-001734-bbeznd3r	192	3	,	,	,
cord-001734-bbeznd3r	192	4	although	although	IN
cord-001734-bbeznd3r	192	5	in	in	IN
cord-001734-bbeznd3r	192	6	the	the	DT
cord-001734-bbeznd3r	192	7	present	present	JJ
cord-001734-bbeznd3r	192	8	study	study	NN
cord-001734-bbeznd3r	192	9	the	the	DT
cord-001734-bbeznd3r	192	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	192	11	peptide	peptide	NN
cord-001734-bbeznd3r	192	12	is	be	VBZ
cord-001734-bbeznd3r	192	13	unlabelled	unlabelled	JJ
cord-001734-bbeznd3r	192	14	,	,	,
cord-001734-bbeznd3r	192	15	a	a	DT
cord-001734-bbeznd3r	192	16	large	large	JJ
cord-001734-bbeznd3r	192	17	portion	portion	NN
cord-001734-bbeznd3r	192	18	of	of	IN
cord-001734-bbeznd3r	192	19	the	the	DT
cord-001734-bbeznd3r	192	20	HSQC	HSQC	NNP
cord-001734-bbeznd3r	192	21	peaks	peak	NNS
cord-001734-bbeznd3r	192	22	of	of	IN
cord-001734-bbeznd3r	192	23	the	the	DT
cord-001734-bbeznd3r	192	24	present	present	JJ
cord-001734-bbeznd3r	192	25	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	192	26	domain	domain	NN
cord-001734-bbeznd3r	192	27	are	be	VBP
cord-001734-bbeznd3r	192	28	almost	almost	RB
cord-001734-bbeznd3r	192	29	superimposable	superimposable	JJ
cord-001734-bbeznd3r	192	30	to	to	IN
cord-001734-bbeznd3r	192	31	those	those	DT
cord-001734-bbeznd3r	192	32	of	of	IN
cord-001734-bbeznd3r	192	33	the	the	DT
cord-001734-bbeznd3r	192	34	previous	previous	JJ
cord-001734-bbeznd3r	192	35	complex	complex	NN
cord-001734-bbeznd3r	192	36	with	with	IN
cord-001734-bbeznd3r	192	37	both	both	DT
cord-001734-bbeznd3r	192	38	NS2B	NS2B	NNP
cord-001734-bbeznd3r	192	39	and	and	CC
cord-001734-bbeznd3r	192	40	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	192	41	15	15	CD
cord-001734-bbeznd3r	192	42	N	n	CD
cord-001734-bbeznd3r	192	43	-	-	HYPH
cord-001734-bbeznd3r	192	44	labelled	label	VBN
cord-001734-bbeznd3r	192	45	and	and	CC
cord-001734-bbeznd3r	192	46	co	co	NNS
cord-001734-bbeznd3r	192	47	-	-	VBN
cord-001734-bbeznd3r	192	48	expressed	express	VBN
cord-001734-bbeznd3r	192	49	[	[	-LRB-
cord-001734-bbeznd3r	192	50	10	10	CD
cord-001734-bbeznd3r	192	51	,	,	,
cord-001734-bbeznd3r	192	52	11	11	CD
cord-001734-bbeznd3r	192	53	]	]	-RRB-
cord-001734-bbeznd3r	192	54	,	,	,
cord-001734-bbeznd3r	192	55	as	as	IN
cord-001734-bbeznd3r	192	56	exemplified	exemplify	VBN
cord-001734-bbeznd3r	192	57	by	by	IN
cord-001734-bbeznd3r	192	58	the	the	DT
cord-001734-bbeznd3r	192	59	characteristic	characteristic	JJ
cord-001734-bbeznd3r	192	60	HSQC	HSQC	NNP
cord-001734-bbeznd3r	192	61	peaks	peak	NNS
cord-001734-bbeznd3r	192	62	(	(	-LRB-
cord-001734-bbeznd3r	192	63	green	green	NNP
cord-001734-bbeznd3r	192	64	cycled	cycle	VBN
cord-001734-bbeznd3r	192	65	)	)	-RRB-
cord-001734-bbeznd3r	192	66	,	,	,
cord-001734-bbeznd3r	192	67	Furthermore	furthermore	RB
cord-001734-bbeznd3r	192	68	,	,	,
cord-001734-bbeznd3r	192	69	the	the	DT
cord-001734-bbeznd3r	192	70	addition	addition	NN
cord-001734-bbeznd3r	192	71	of	of	IN
cord-001734-bbeznd3r	192	72	the	the	DT
cord-001734-bbeznd3r	192	73	protease	protease	JJ
cord-001734-bbeznd3r	192	74	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	192	75	p	p	NN
cord-001734-bbeznd3r	192	76	-	-	:
cord-001734-bbeznd3r	192	77	Nitrophenyl	Nitrophenyl	NNP
cord-001734-bbeznd3r	192	78	-	-	HYPH
cord-001734-bbeznd3r	192	79	p	p	NN
cord-001734-bbeznd3r	192	80	-	-	HYPH
cord-001734-bbeznd3r	192	81	guanidino	guanidino	JJ
cord-001734-bbeznd3r	192	82	benzoate	benzoate	NN
cord-001734-bbeznd3r	192	83	previously	previously	RB
cord-001734-bbeznd3r	192	84	used	use	VBD
cord-001734-bbeznd3r	192	85	[	[	-LRB-
cord-001734-bbeznd3r	192	86	11	11	CD
cord-001734-bbeznd3r	192	87	]	]	-RRB-
cord-001734-bbeznd3r	192	88	triggered	trigger	VBN
cord-001734-bbeznd3r	192	89	dramatic	dramatic	JJ
cord-001734-bbeznd3r	192	90	shifts	shift	NNS
cord-001734-bbeznd3r	192	91	of	of	IN
cord-001734-bbeznd3r	192	92	many	many	JJ
cord-001734-bbeznd3r	192	93	HSQC	HSQC	NNP
cord-001734-bbeznd3r	192	94	peaks	peak	NNS
cord-001734-bbeznd3r	192	95	,	,	,
cord-001734-bbeznd3r	192	96	indicating	indicate	VBG
cord-001734-bbeznd3r	192	97	the	the	DT
cord-001734-bbeznd3r	192	98	refolded	refolde	VBN
cord-001734-bbeznd3r	192	99	NS2B	NS2B	NNP
cord-001734-bbeznd3r	192	100	-	-	HYPH
cord-001734-bbeznd3r	192	101	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	192	102	is	be	VBZ
cord-001734-bbeznd3r	192	103	active	active	JJ
cord-001734-bbeznd3r	192	104	in	in	IN
cord-001734-bbeznd3r	192	105	binding	bind	VBG
cord-001734-bbeznd3r	192	106	the	the	DT
cord-001734-bbeznd3r	192	107	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	192	108	(	(	-LRB-
cord-001734-bbeznd3r	192	109	Fig	Fig	NNP
cord-001734-bbeznd3r	192	110	3E	3E	NNP
cord-001734-bbeznd3r	192	111	)	)	-RRB-
cord-001734-bbeznd3r	192	112	.	.	.
cord-001734-bbeznd3r	193	1	We	-PRON-	PRP
cord-001734-bbeznd3r	193	2	measured	measure	VBD
cord-001734-bbeznd3r	193	3	the	the	DT
cord-001734-bbeznd3r	193	4	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	193	5	activity	activity	NN
cord-001734-bbeznd3r	193	6	of	of	IN
cord-001734-bbeznd3r	193	7	the	the	DT
cord-001734-bbeznd3r	193	8	complex	complex	NN
cord-001734-bbeznd3r	193	9	refolded	refolde	VBD
cord-001734-bbeznd3r	193	10	at	at	IN
cord-001734-bbeznd3r	193	11	pH	pH	NNP
cord-001734-bbeznd3r	193	12	4.0	4.0	CD
cord-001734-bbeznd3r	193	13	in	in	IN
cord-001734-bbeznd3r	193	14	two	two	CD
cord-001734-bbeznd3r	193	15	buffers	buffer	NNS
cord-001734-bbeznd3r	193	16	:	:	:
cord-001734-bbeznd3r	193	17	one	one	CD
cord-001734-bbeznd3r	193	18	at	at	IN
cord-001734-bbeznd3r	193	19	pH	pH	NNP
cord-001734-bbeznd3r	193	20	4.0	4.0	CD
cord-001734-bbeznd3r	193	21	and	and	CC
cord-001734-bbeznd3r	193	22	another	another	DT
cord-001734-bbeznd3r	193	23	at	at	IN
cord-001734-bbeznd3r	193	24	pH	pH	NNP
cord-001734-bbeznd3r	193	25	7.5	7.5	CD
cord-001734-bbeznd3r	193	26	.	.	.
cord-001734-bbeznd3r	194	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	194	2	,	,	,
cord-001734-bbeznd3r	194	3	it	-PRON-	PRP
cord-001734-bbeznd3r	194	4	has	have	VBZ
cord-001734-bbeznd3r	194	5	no	no	DT
cord-001734-bbeznd3r	194	6	detectable	detectable	JJ
cord-001734-bbeznd3r	194	7	activity	activity	NN
cord-001734-bbeznd3r	194	8	in	in	IN
cord-001734-bbeznd3r	194	9	the	the	DT
cord-001734-bbeznd3r	194	10	acetate	acetate	NN
cord-001734-bbeznd3r	194	11	buffer	buffer	NN
cord-001734-bbeznd3r	194	12	at	at	IN
cord-001734-bbeznd3r	194	13	pH	pH	NNP
cord-001734-bbeznd3r	194	14	4.0	4.0	CD
cord-001734-bbeznd3r	194	15	even	even	RB
cord-001734-bbeznd3r	194	16	with	with	IN
cord-001734-bbeznd3r	194	17	the	the	DT
cord-001734-bbeznd3r	194	18	protein	protein	NN
cord-001734-bbeznd3r	194	19	concentration	concentration	NN
cord-001734-bbeznd3r	194	20	reaching	reach	VBG
cord-001734-bbeznd3r	194	21	5	5	CD
cord-001734-bbeznd3r	195	1	μM.	μM.	NNP
cord-001734-bbeznd3r	196	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	196	2	,	,	,
cord-001734-bbeznd3r	196	3	if	if	IN
cord-001734-bbeznd3r	196	4	the	the	DT
cord-001734-bbeznd3r	196	5	sample	sample	NN
cord-001734-bbeznd3r	196	6	refolded	refolde	VBD
cord-001734-bbeznd3r	196	7	at	at	IN
cord-001734-bbeznd3r	196	8	pH	pH	NNP
cord-001734-bbeznd3r	196	9	4.0	4.0	CD
cord-001734-bbeznd3r	196	10	was	be	VBD
cord-001734-bbeznd3r	196	11	measured	measure	VBN
cord-001734-bbeznd3r	196	12	in	in	IN
cord-001734-bbeznd3r	196	13	the	the	DT
cord-001734-bbeznd3r	196	14	buffer	buffer	NN
cord-001734-bbeznd3r	196	15	at	at	IN
cord-001734-bbeznd3r	196	16	pH	pH	NNP
cord-001734-bbeznd3r	196	17	7.5	7.5	CD
cord-001734-bbeznd3r	196	18	,	,	,
cord-001734-bbeznd3r	196	19	it	-PRON-	PRP
cord-001734-bbeznd3r	196	20	is	be	VBZ
cord-001734-bbeznd3r	196	21	highly	highly	RB
cord-001734-bbeznd3r	196	22	active	active	JJ
cord-001734-bbeznd3r	196	23	with	with	IN
cord-001734-bbeznd3r	196	24	no	no	DT
cord-001734-bbeznd3r	196	25	detectable	detectable	JJ
cord-001734-bbeznd3r	196	26	difference	difference	NN
cord-001734-bbeznd3r	196	27	from	from	IN
cord-001734-bbeznd3r	196	28	that	that	DT
cord-001734-bbeznd3r	196	29	refolded	refolde	VBD
cord-001734-bbeznd3r	196	30	in	in	IN
cord-001734-bbeznd3r	196	31	the	the	DT
cord-001734-bbeznd3r	196	32	buffer	buffer	NN
cord-001734-bbeznd3r	196	33	at	at	IN
cord-001734-bbeznd3r	196	34	pH	pH	NNP
cord-001734-bbeznd3r	196	35	7.5	7.5	CD
cord-001734-bbeznd3r	197	1	(	(	-LRB-
cord-001734-bbeznd3r	197	2	Fig	Fig	NNP
cord-001734-bbeznd3r	197	3	3B	3b	CD
cord-001734-bbeznd3r	197	4	)	)	-RRB-
cord-001734-bbeznd3r	197	5	.	.	.
cord-001734-bbeznd3r	198	1	The	the	DT
cord-001734-bbeznd3r	198	2	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	198	3	parameters	parameter	NNS
cord-001734-bbeznd3r	198	4	of	of	IN
cord-001734-bbeznd3r	198	5	the	the	DT
cord-001734-bbeznd3r	198	6	refolded	refolde	VBN
cord-001734-bbeznd3r	198	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	198	8	-	-	HYPH
cord-001734-bbeznd3r	198	9	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	198	10	complex	complex	NN
cord-001734-bbeznd3r	198	11	in	in	IN
cord-001734-bbeznd3r	198	12	the	the	DT
cord-001734-bbeznd3r	198	13	buffer	buffer	NN
cord-001734-bbeznd3r	198	14	at	at	IN
cord-001734-bbeznd3r	198	15	pH	pH	NNP
cord-001734-bbeznd3r	198	16	7.5	7.5	CD
cord-001734-bbeznd3r	198	17	were	be	VBD
cord-001734-bbeznd3r	198	18	obtained	obtain	VBN
cord-001734-bbeznd3r	198	19	with	with	IN
cord-001734-bbeznd3r	198	20	Km	km	NN
cord-001734-bbeznd3r	198	21	=	=	NFP
cord-001734-bbeznd3r	199	1	92.39	92.39	CD
cord-001734-bbeznd3r	199	2	±	±	CD
cord-001734-bbeznd3r	199	3	9.94	9.94	CD
cord-001734-bbeznd3r	200	1	μM	μM	NNP
cord-001734-bbeznd3r	200	2	and	and	CC
cord-001734-bbeznd3r	200	3	Kcat	Kcat	NNP
cord-001734-bbeznd3r	200	4	=	=	SYM
cord-001734-bbeznd3r	200	5	0.15	0.15	CD
cord-001734-bbeznd3r	200	6	±	±	CD
cord-001734-bbeznd3r	200	7	0.01	0.01	CD
cord-001734-bbeznd3r	200	8	s	s	NNP
cord-001734-bbeznd3r	200	9	-1	-1	NN
cord-001734-bbeznd3r	200	10	,	,	,
cord-001734-bbeznd3r	200	11	which	which	WDT
cord-001734-bbeznd3r	200	12	are	be	VBP
cord-001734-bbeznd3r	200	13	very	very	RB
cord-001734-bbeznd3r	200	14	similar	similar	JJ
cord-001734-bbeznd3r	200	15	to	to	IN
cord-001734-bbeznd3r	200	16	the	the	DT
cord-001734-bbeznd3r	200	17	previous	previous	JJ
cord-001734-bbeznd3r	200	18	results	result	NNS
cord-001734-bbeznd3r	200	19	with	with	IN
cord-001734-bbeznd3r	200	20	a	a	DT
cord-001734-bbeznd3r	200	21	co	co	NN
cord-001734-bbeznd3r	200	22	-	-	VBN
cord-001734-bbeznd3r	200	23	expressed	express	VBN
cord-001734-bbeznd3r	200	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	200	25	-	-	HYPH
cord-001734-bbeznd3r	200	26	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	200	27	complex	complex	NN
cord-001734-bbeznd3r	200	28	[	[	-LRB-
cord-001734-bbeznd3r	200	29	10	10	CD
cord-001734-bbeznd3r	200	30	]	]	-RRB-
cord-001734-bbeznd3r	200	31	.	.	.
cord-001734-bbeznd3r	201	1	The	the	DT
cord-001734-bbeznd3r	201	2	structure	structure	NN
cord-001734-bbeznd3r	201	3	and	and	CC
cord-001734-bbeznd3r	201	4	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	201	5	activity	activity	NN
cord-001734-bbeznd3r	201	6	revealed	reveal	VBD
cord-001734-bbeznd3r	201	7	that	that	IN
cord-001734-bbeznd3r	201	8	once	once	RB
cord-001734-bbeznd3r	201	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	201	10	and	and	CC
cord-001734-bbeznd3r	201	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	201	12	meet	meet	VBP
cord-001734-bbeznd3r	201	13	,	,	,
cord-001734-bbeznd3r	201	14	they	-PRON-	PRP
cord-001734-bbeznd3r	201	15	will	will	MD
cord-001734-bbeznd3r	201	16	bind	bind	VB
cord-001734-bbeznd3r	201	17	to	to	IN
cord-001734-bbeznd3r	201	18	each	each	DT
cord-001734-bbeznd3r	201	19	other	other	JJ
cord-001734-bbeznd3r	201	20	and	and	CC
cord-001734-bbeznd3r	201	21	initiate	initiate	VB
cord-001734-bbeznd3r	201	22	the	the	DT
cord-001734-bbeznd3r	201	23	folding	folding	NN
cord-001734-bbeznd3r	201	24	process	process	NN
cord-001734-bbeznd3r	201	25	to	to	TO
cord-001734-bbeznd3r	201	26	form	form	VB
cord-001734-bbeznd3r	201	27	the	the	DT
cord-001734-bbeznd3r	201	28	two	two	CD
cord-001734-bbeznd3r	201	29	-	-	HYPH
cord-001734-bbeznd3r	201	30	component	component	NN
cord-001734-bbeznd3r	201	31	complex	complex	NN
cord-001734-bbeznd3r	201	32	.	.	.
cord-001734-bbeznd3r	202	1	However	however	RB
cord-001734-bbeznd3r	202	2	,	,	,
cord-001734-bbeznd3r	202	3	it	-PRON-	PRP
cord-001734-bbeznd3r	202	4	seems	seem	VBZ
cord-001734-bbeznd3r	202	5	that	that	IN
cord-001734-bbeznd3r	202	6	if	if	IN
cord-001734-bbeznd3r	202	7	at	at	IN
cord-001734-bbeznd3r	202	8	pH	pH	NNP
cord-001734-bbeznd3r	202	9	4.0	4.0	CD
cord-001734-bbeznd3r	202	10	,	,	,
cord-001734-bbeznd3r	202	11	the	the	DT
cord-001734-bbeznd3r	202	12	NS2B	NS2B	NNP
cord-001734-bbeznd3r	202	13	-	-	HYPH
cord-001734-bbeznd3r	202	14	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	202	15	complex	complex	NN
cord-001734-bbeznd3r	202	16	exists	exist	VBZ
cord-001734-bbeznd3r	202	17	as	as	IN
cord-001734-bbeznd3r	202	18	an	an	DT
cord-001734-bbeznd3r	202	19	intermediate	intermediate	NN
cord-001734-bbeznd3r	202	20	which	which	WDT
cord-001734-bbeznd3r	202	21	already	already	RB
cord-001734-bbeznd3r	202	22	has	have	VBZ
cord-001734-bbeznd3r	202	23	substantial	substantial	JJ
cord-001734-bbeznd3r	202	24	secondary	secondary	JJ
cord-001734-bbeznd3r	202	25	structures	structure	NNS
cord-001734-bbeznd3r	202	26	and	and	CC
cord-001734-bbeznd3r	202	27	tertiary	tertiary	JJ
cord-001734-bbeznd3r	202	28	packing	packing	NN
cord-001734-bbeznd3r	202	29	.	.	.
cord-001734-bbeznd3r	203	1	However	however	RB
cord-001734-bbeznd3r	203	2	,	,	,
cord-001734-bbeznd3r	203	3	the	the	DT
cord-001734-bbeznd3r	203	4	tight	tight	JJ
cord-001734-bbeznd3r	203	5	tertiary	tertiary	JJ
cord-001734-bbeznd3r	203	6	packing	packing	NN
cord-001734-bbeznd3r	203	7	is	be	VBZ
cord-001734-bbeznd3r	203	8	not	not	RB
cord-001734-bbeznd3r	203	9	completely	completely	RB
cord-001734-bbeznd3r	203	10	achieved	achieve	VBN
cord-001734-bbeznd3r	203	11	and	and	CC
cord-001734-bbeznd3r	203	12	consequently	consequently	RB
cord-001734-bbeznd3r	203	13	the	the	DT
cord-001734-bbeznd3r	203	14	complex	complex	JJ
cord-001734-bbeznd3r	203	15	undergoes	undergo	VBZ
cord-001734-bbeznd3r	203	16	μs	μs	NNP
cord-001734-bbeznd3r	203	17	-	-	HYPH
cord-001734-bbeznd3r	203	18	ms	ms	NNP
cord-001734-bbeznd3r	203	19	conformational	conformational	JJ
cord-001734-bbeznd3r	203	20	exchanges	exchange	NNS
cord-001734-bbeznd3r	203	21	,	,	,
cord-001734-bbeznd3r	203	22	very	very	RB
cord-001734-bbeznd3r	203	23	similar	similar	JJ
cord-001734-bbeznd3r	203	24	to	to	IN
cord-001734-bbeznd3r	203	25	what	what	WP
cord-001734-bbeznd3r	203	26	we	-PRON-	PRP
cord-001734-bbeznd3r	203	27	previously	previously	RB
cord-001734-bbeznd3r	203	28	observed	observe	VBD
cord-001734-bbeznd3r	203	29	on	on	IN
cord-001734-bbeznd3r	203	30	a	a	DT
cord-001734-bbeznd3r	203	31	molten	molten	JJ
cord-001734-bbeznd3r	203	32	globule	globule	NN
cord-001734-bbeznd3r	203	33	formed	form	VBN
cord-001734-bbeznd3r	203	34	by	by	IN
cord-001734-bbeznd3r	203	35	a	a	DT
cord-001734-bbeznd3r	203	36	small	small	JJ
cord-001734-bbeznd3r	203	37	protein	protein	NN
cord-001734-bbeznd3r	203	38	at	at	IN
cord-001734-bbeznd3r	203	39	pH	pH	NNP
cord-001734-bbeznd3r	203	40	4.0	4.0	CD
cord-001734-bbeznd3r	203	41	[	[	-LRB-
cord-001734-bbeznd3r	203	42	39	39	CD
cord-001734-bbeznd3r	203	43	,	,	,
cord-001734-bbeznd3r	203	44	40	40	CD
cord-001734-bbeznd3r	203	45	]	]	-RRB-
cord-001734-bbeznd3r	203	46	.	.	.
cord-001734-bbeznd3r	204	1	The	the	DT
cord-001734-bbeznd3r	204	2	intermediate	intermediate	NN
cord-001734-bbeznd3r	204	3	of	of	IN
cord-001734-bbeznd3r	204	4	the	the	DT
cord-001734-bbeznd3r	204	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	204	6	-	-	HYPH
cord-001734-bbeznd3r	204	7	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	204	8	complex	complex	NN
cord-001734-bbeznd3r	204	9	at	at	IN
cord-001734-bbeznd3r	204	10	pH	pH	NNP
cord-001734-bbeznd3r	204	11	4.0	4.0	CD
cord-001734-bbeznd3r	204	12	is	be	VBZ
cord-001734-bbeznd3r	204	13	enzymatically	enzymatically	RB
cord-001734-bbeznd3r	204	14	inactive	inactive	JJ
cord-001734-bbeznd3r	204	15	,	,	,
cord-001734-bbeznd3r	204	16	but	but	CC
cord-001734-bbeznd3r	204	17	nevertheless	nevertheless	RB
cord-001734-bbeznd3r	204	18	,	,	,
cord-001734-bbeznd3r	204	19	once	once	IN
cord-001734-bbeznd3r	204	20	it	-PRON-	PRP
cord-001734-bbeznd3r	204	21	is	be	VBZ
cord-001734-bbeznd3r	204	22	transferred	transfer	VBN
cord-001734-bbeznd3r	204	23	into	into	IN
cord-001734-bbeznd3r	204	24	the	the	DT
cord-001734-bbeznd3r	204	25	buffer	buffer	NN
cord-001734-bbeznd3r	204	26	at	at	IN
cord-001734-bbeznd3r	204	27	pH	pH	NNP
cord-001734-bbeznd3r	204	28	7.5	7.5	CD
cord-001734-bbeznd3r	204	29	,	,	,
cord-001734-bbeznd3r	204	30	the	the	DT
cord-001734-bbeznd3r	204	31	tightly	tightly	RB
cord-001734-bbeznd3r	204	32	-	-	HYPH
cord-001734-bbeznd3r	204	33	packed	pack	VBN
cord-001734-bbeznd3r	204	34	structure	structure	NN
cord-001734-bbeznd3r	204	35	will	will	MD
cord-001734-bbeznd3r	204	36	immediately	immediately	RB
cord-001734-bbeznd3r	204	37	form	form	VB
cord-001734-bbeznd3r	204	38	and	and	CC
cord-001734-bbeznd3r	204	39	the	the	DT
cord-001734-bbeznd3r	204	40	complex	complex	NN
cord-001734-bbeznd3r	204	41	can	can	MD
cord-001734-bbeznd3r	204	42	reach	reach	VB
cord-001734-bbeznd3r	204	43	the	the	DT
cord-001734-bbeznd3r	204	44	fully	fully	RB
cord-001734-bbeznd3r	204	45	active	active	JJ
cord-001734-bbeznd3r	204	46	state	state	NN
cord-001734-bbeznd3r	204	47	.	.	.
cord-001734-bbeznd3r	205	1	To	to	TO
cord-001734-bbeznd3r	205	2	study	study	VB
cord-001734-bbeznd3r	205	3	the	the	DT
cord-001734-bbeznd3r	205	4	structure	structure	NN
cord-001734-bbeznd3r	205	5	and	and	CC
cord-001734-bbeznd3r	205	6	activity	activity	NN
cord-001734-bbeznd3r	205	7	of	of	IN
cord-001734-bbeznd3r	205	8	the	the	DT
cord-001734-bbeznd3r	205	9	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	205	10	in	in	IN
cord-001734-bbeznd3r	205	11	complex	complex	NN
cord-001734-bbeznd3r	205	12	with	with	IN
cord-001734-bbeznd3r	205	13	the	the	DT
cord-001734-bbeznd3r	205	14	full	full	JJ
cord-001734-bbeznd3r	205	15	-	-	HYPH
cord-001734-bbeznd3r	205	16	length	length	NN
cord-001734-bbeznd3r	205	17	NS2B	NS2B	NNP
cord-001734-bbeznd3r	205	18	(	(	-LRB-
cord-001734-bbeznd3r	205	19	1	1	CD
cord-001734-bbeznd3r	205	20	-	-	SYM
cord-001734-bbeznd3r	205	21	130	130	CD
cord-001734-bbeznd3r	205	22	)	)	-RRB-
cord-001734-bbeznd3r	205	23	,	,	,
cord-001734-bbeznd3r	205	24	which	which	WDT
cord-001734-bbeznd3r	205	25	is	be	VBZ
cord-001734-bbeznd3r	205	26	expected	expect	VBN
cord-001734-bbeznd3r	205	27	to	to	TO
cord-001734-bbeznd3r	205	28	be	be	VB
cord-001734-bbeznd3r	205	29	anchored	anchor	VBN
cord-001734-bbeznd3r	205	30	into	into	IN
cord-001734-bbeznd3r	205	31	the	the	DT
cord-001734-bbeznd3r	205	32	membranes	membrane	NNS
cord-001734-bbeznd3r	205	33	by	by	IN
cord-001734-bbeznd3r	205	34	forming	form	VBG
cord-001734-bbeznd3r	205	35	the	the	DT
cord-001734-bbeznd3r	205	36	transmembrane	transmembrane	NN
cord-001734-bbeznd3r	205	37	helices	helix	NNS
cord-001734-bbeznd3r	205	38	at	at	IN
cord-001734-bbeznd3r	205	39	both	both	CC
cord-001734-bbeznd3r	205	40	N	N	NNP
cord-001734-bbeznd3r	205	41	-	-	HYPH
cord-001734-bbeznd3r	205	42	and	and	CC
cord-001734-bbeznd3r	205	43	C	C	NNP
cord-001734-bbeznd3r	205	44	-	-	HYPH
cord-001734-bbeznd3r	205	45	termini	termini	NNP
cord-001734-bbeznd3r	205	46	,	,	,
cord-001734-bbeznd3r	205	47	the	the	DT
cord-001734-bbeznd3r	205	48	DNA	dna	NN
cord-001734-bbeznd3r	205	49	fragment	fragment	NN
cord-001734-bbeznd3r	205	50	encoding	encoding	NN
cord-001734-bbeznd3r	206	1	the	the	DT
cord-001734-bbeznd3r	206	2	full	full	JJ
cord-001734-bbeznd3r	206	3	-	-	HYPH
cord-001734-bbeznd3r	206	4	length	length	NN
cord-001734-bbeznd3r	206	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	206	6	(	(	-LRB-
cord-001734-bbeznd3r	206	7	1	1	CD
cord-001734-bbeznd3r	206	8	-	-	SYM
cord-001734-bbeznd3r	206	9	130	130	CD
cord-001734-bbeznd3r	206	10	)	)	-RRB-
cord-001734-bbeznd3r	206	11	was	be	VBD
cord-001734-bbeznd3r	206	12	cloned	clone	VBN
cord-001734-bbeznd3r	206	13	into	into	IN
cord-001734-bbeznd3r	206	14	pET28a	pet28a	JJ
cord-001734-bbeznd3r	206	15	vector	vector	NN
cord-001734-bbeznd3r	206	16	and	and	CC
cord-001734-bbeznd3r	206	17	the	the	DT
cord-001734-bbeznd3r	206	18	NS2B	NS2B	NNP
cord-001734-bbeznd3r	207	1	(	(	-LRB-
cord-001734-bbeznd3r	207	2	1	1	CD
cord-001734-bbeznd3r	207	3	-	-	SYM
cord-001734-bbeznd3r	207	4	130	130	CD
cord-001734-bbeznd3r	207	5	)	)	-RRB-
cord-001734-bbeznd3r	207	6	protein	protein	NN
cord-001734-bbeznd3r	207	7	was	be	VBD
cord-001734-bbeznd3r	207	8	purified	purify	VBN
cord-001734-bbeznd3r	207	9	under	under	IN
cord-001734-bbeznd3r	207	10	denaturing	denature	VBG
cord-001734-bbeznd3r	207	11	condition	condition	NN
cord-001734-bbeznd3r	207	12	.	.	.
cord-001734-bbeznd3r	208	1	The	the	DT
cord-001734-bbeznd3r	208	2	full	full	JJ
cord-001734-bbeznd3r	208	3	-	-	HYPH
cord-001734-bbeznd3r	208	4	length	length	NN
cord-001734-bbeznd3r	208	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	208	6	(	(	-LRB-
cord-001734-bbeznd3r	208	7	1	1	CD
cord-001734-bbeznd3r	208	8	-	-	SYM
cord-001734-bbeznd3r	208	9	130	130	CD
cord-001734-bbeznd3r	208	10	)	)	-RRB-
cord-001734-bbeznd3r	208	11	was	be	VBD
cord-001734-bbeznd3r	208	12	reconstituted	reconstitute	VBN
cord-001734-bbeznd3r	208	13	in	in	IN
cord-001734-bbeznd3r	208	14	the	the	DT
cord-001734-bbeznd3r	208	15	LMPC	LMPC	NNP
cord-001734-bbeznd3r	208	16	micelle	micelle	NN
cord-001734-bbeznd3r	208	17	at	at	IN
cord-001734-bbeznd3r	208	18	a	a	DT
cord-001734-bbeznd3r	208	19	molar	molar	JJ
cord-001734-bbeznd3r	208	20	ratio	ratio	NN
cord-001734-bbeznd3r	208	21	of	of	IN
cord-001734-bbeznd3r	208	22	1:200	1:200	CD
cord-001734-bbeznd3r	209	1	(	(	-LRB-
cord-001734-bbeznd3r	209	2	NS2B	NS2B	NNP
cord-001734-bbeznd3r	209	3	:	:	:
cord-001734-bbeznd3r	209	4	LMPC	LMPC	NNP
cord-001734-bbeznd3r	209	5	)	)	-RRB-
cord-001734-bbeznd3r	210	1	in	in	IN
cord-001734-bbeznd3r	210	2	buffer	buffer	NN
cord-001734-bbeznd3r	210	3	(	(	-LRB-
cord-001734-bbeznd3r	210	4	pH	pH	NNP
cord-001734-bbeznd3r	210	5	7.5	7.5	CD
cord-001734-bbeznd3r	210	6	)	)	-RRB-
cord-001734-bbeznd3r	210	7	.	.	.
cord-001734-bbeznd3r	211	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	211	2	,	,	,
cord-001734-bbeznd3r	211	3	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	211	4	and	and	CC
cord-001734-bbeznd3r	211	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	211	6	(	(	-LRB-
cord-001734-bbeznd3r	211	7	1	1	CD
cord-001734-bbeznd3r	211	8	-	-	SYM
cord-001734-bbeznd3r	211	9	130	130	CD
cord-001734-bbeznd3r	211	10	)	)	-RRB-
cord-001734-bbeznd3r	211	11	were	be	VBD
cord-001734-bbeznd3r	211	12	also	also	RB
cord-001734-bbeznd3r	211	13	refolded	refolde	VBN
cord-001734-bbeznd3r	211	14	together	together	RB
cord-001734-bbeznd3r	211	15	at	at	IN
cord-001734-bbeznd3r	211	16	the	the	DT
cord-001734-bbeznd3r	211	17	equimolar	equimolar	JJ
cord-001734-bbeznd3r	211	18	concentrations	concentration	NNS
cord-001734-bbeznd3r	211	19	in	in	IN
cord-001734-bbeznd3r	211	20	presence	presence	NN
cord-001734-bbeznd3r	211	21	of	of	IN
cord-001734-bbeznd3r	211	22	LMPC	LMPC	NNP
cord-001734-bbeznd3r	211	23	in	in	IN
cord-001734-bbeznd3r	211	24	buffer	buffer	NN
cord-001734-bbeznd3r	211	25	(	(	-LRB-
cord-001734-bbeznd3r	211	26	pH	pH	NNP
cord-001734-bbeznd3r	211	27	7.5	7.5	CD
cord-001734-bbeznd3r	211	28	)	)	-RRB-
cord-001734-bbeznd3r	211	29	.	.	.
cord-001734-bbeznd3r	212	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	212	2	,	,	,
cord-001734-bbeznd3r	212	3	the	the	DT
cord-001734-bbeznd3r	212	4	far	far	JJ
cord-001734-bbeznd3r	212	5	-	-	HYPH
cord-001734-bbeznd3r	212	6	UV	uv	NN
cord-001734-bbeznd3r	212	7	CD	cd	NN
cord-001734-bbeznd3r	212	8	spectrum	spectrum	NN
cord-001734-bbeznd3r	212	9	of	of	IN
cord-001734-bbeznd3r	212	10	the	the	DT
cord-001734-bbeznd3r	212	11	full	full	JJ
cord-001734-bbeznd3r	212	12	-	-	HYPH
cord-001734-bbeznd3r	212	13	length	length	NN
cord-001734-bbeznd3r	212	14	NS2B	NS2B	NNP
cord-001734-bbeznd3r	212	15	(	(	-LRB-
cord-001734-bbeznd3r	212	16	1	1	CD
cord-001734-bbeznd3r	212	17	-	-	SYM
cord-001734-bbeznd3r	212	18	130	130	CD
cord-001734-bbeznd3r	212	19	)	)	-RRB-
cord-001734-bbeznd3r	212	20	reconstituted	reconstitute	VBN
cord-001734-bbeznd3r	212	21	in	in	IN
cord-001734-bbeznd3r	212	22	the	the	DT
cord-001734-bbeznd3r	212	23	LMPC	LMPC	NNP
cord-001734-bbeznd3r	212	24	micelle	micelle	NN
cord-001734-bbeznd3r	212	25	have	have	VBP
cord-001734-bbeznd3r	212	26	the	the	DT
cord-001734-bbeznd3r	212	27	maximal	maximal	JJ
cord-001734-bbeznd3r	212	28	negative	negative	JJ
cord-001734-bbeznd3r	212	29	signal	signal	NN
cord-001734-bbeznd3r	212	30	at	at	IN
cord-001734-bbeznd3r	212	31	209	209	CD
cord-001734-bbeznd3r	212	32	nm	nm	NN
cord-001734-bbeznd3r	212	33	and	and	CC
cord-001734-bbeznd3r	212	34	positive	positive	JJ
cord-001734-bbeznd3r	212	35	signal	signal	NN
cord-001734-bbeznd3r	212	36	at	at	IN
cord-001734-bbeznd3r	212	37	192	192	CD
cord-001734-bbeznd3r	212	38	nm	nm	NN
cord-001734-bbeznd3r	212	39	,	,	,
cord-001734-bbeznd3r	212	40	as	as	RB
cord-001734-bbeznd3r	212	41	well	well	RB
cord-001734-bbeznd3r	212	42	as	as	IN
cord-001734-bbeznd3r	212	43	an	an	DT
cord-001734-bbeznd3r	212	44	additional	additional	JJ
cord-001734-bbeznd3r	212	45	negative	negative	JJ
cord-001734-bbeznd3r	212	46	signal	signal	NN
cord-001734-bbeznd3r	212	47	at	at	IN
cord-001734-bbeznd3r	212	48	222	222	CD
cord-001734-bbeznd3r	212	49	nm	nm	NN
cord-001734-bbeznd3r	212	50	(	(	-LRB-
cord-001734-bbeznd3r	212	51	Fig	fig	NN
cord-001734-bbeznd3r	212	52	4A	4a	CD
cord-001734-bbeznd3r	212	53	)	)	-RRB-
cord-001734-bbeznd3r	212	54	.	.	.
cord-001734-bbeznd3r	213	1	The	the	DT
cord-001734-bbeznd3r	213	2	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	213	3	reveals	reveal	VBZ
cord-001734-bbeznd3r	213	4	that	that	IN
cord-001734-bbeznd3r	213	5	the	the	DT
cord-001734-bbeznd3r	213	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	213	7	(	(	-LRB-
cord-001734-bbeznd3r	213	8	1	1	CD
cord-001734-bbeznd3r	213	9	-	-	SYM
cord-001734-bbeznd3r	213	10	130	130	CD
cord-001734-bbeznd3r	213	11	)	)	-RRB-
cord-001734-bbeznd3r	213	12	reconstituted	reconstitute	VBN
cord-001734-bbeznd3r	213	13	in	in	IN
cord-001734-bbeznd3r	213	14	the	the	DT
cord-001734-bbeznd3r	213	15	LMPC	LMPC	NNP
cord-001734-bbeznd3r	213	16	micelle	micelle	NN
cord-001734-bbeznd3r	213	17	contains	contain	VBZ
cord-001734-bbeznd3r	213	18	28	28	CD
cord-001734-bbeznd3r	213	19	%	%	NN
cord-001734-bbeznd3r	213	20	random	random	JJ
cord-001734-bbeznd3r	213	21	coil	coil	NN
cord-001734-bbeznd3r	213	22	,	,	,
cord-001734-bbeznd3r	213	23	23	23	CD
cord-001734-bbeznd3r	213	24	%	%	NN
cord-001734-bbeznd3r	213	25	turn	turn	NN
cord-001734-bbeznd3r	213	26	,	,	,
cord-001734-bbeznd3r	213	27	17	17	CD
cord-001734-bbeznd3r	213	28	%	%	NN
cord-001734-bbeznd3r	213	29	extended	extended	JJ
cord-001734-bbeznd3r	213	30	strand	strand	NN
cord-001734-bbeznd3r	213	31	and	and	CC
cord-001734-bbeznd3r	213	32	32	32	CD
cord-001734-bbeznd3r	213	33	%	%	NN
cord-001734-bbeznd3r	213	34	helix	helix	NN
cord-001734-bbeznd3r	213	35	secondary	secondary	JJ
cord-001734-bbeznd3r	213	36	structures	structure	NNS
cord-001734-bbeznd3r	213	37	.	.	.
cord-001734-bbeznd3r	214	1	The	the	DT
cord-001734-bbeznd3r	214	2	large	large	JJ
cord-001734-bbeznd3r	214	3	portion	portion	NN
cord-001734-bbeznd3r	214	4	of	of	IN
cord-001734-bbeznd3r	214	5	the	the	DT
cord-001734-bbeznd3r	214	6	helix	helix	NN
cord-001734-bbeznd3r	214	7	conformation	conformation	NN
cord-001734-bbeznd3r	214	8	is	be	VBZ
cord-001734-bbeznd3r	214	9	anticipated	anticipate	VBN
cord-001734-bbeznd3r	214	10	to	to	TO
cord-001734-bbeznd3r	214	11	result	result	VB
cord-001734-bbeznd3r	214	12	from	from	IN
cord-001734-bbeznd3r	214	13	the	the	DT
cord-001734-bbeznd3r	214	14	formation	formation	NN
cord-001734-bbeznd3r	214	15	of	of	IN
cord-001734-bbeznd3r	214	16	the	the	DT
cord-001734-bbeznd3r	214	17	transmembrane	transmembrane	NNP
cord-001734-bbeznd3r	214	18	helices	helix	NNS
cord-001734-bbeznd3r	214	19	at	at	IN
cord-001734-bbeznd3r	214	20	both	both	DT
cord-001734-bbeznd3r	214	21	of	of	IN
cord-001734-bbeznd3r	214	22	N	N	NNP
cord-001734-bbeznd3r	214	23	-	-	:
cord-001734-bbeznd3r	214	24	and	and	CC
cord-001734-bbeznd3r	214	25	C	C	NNP
cord-001734-bbeznd3r	214	26	-	-	HYPH
cord-001734-bbeznd3r	214	27	terminal	terminal	NN
cord-001734-bbeznd3r	214	28	termini	terminus	NNS
cord-001734-bbeznd3r	214	29	.	.	.
cord-001734-bbeznd3r	215	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	215	2	,	,	,
cord-001734-bbeznd3r	215	3	the	the	DT
cord-001734-bbeznd3r	215	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	215	5	(	(	-LRB-
cord-001734-bbeznd3r	215	6	1	1	CD
cord-001734-bbeznd3r	215	7	-	-	SYM
cord-001734-bbeznd3r	215	8	130	130	CD
cord-001734-bbeznd3r	215	9	)	)	-RRB-
cord-001734-bbeznd3r	215	10	in	in	IN
cord-001734-bbeznd3r	215	11	the	the	DT
cord-001734-bbeznd3r	215	12	LMPC	LMPC	NNP
cord-001734-bbeznd3r	215	13	micelle	micelle	NN
cord-001734-bbeznd3r	215	14	has~10	has~10	CD
cord-001734-bbeznd3r	215	15	%	%	NN
cord-001734-bbeznd3r	215	16	higher	high	JJR
cord-001734-bbeznd3r	215	17	β	β	NN
cord-001734-bbeznd3r	215	18	-	-	HYPH
cord-001734-bbeznd3r	215	19	strand	strand	NN
cord-001734-bbeznd3r	215	20	conformation	conformation	NN
cord-001734-bbeznd3r	215	21	than	than	IN
cord-001734-bbeznd3r	215	22	the	the	DT
cord-001734-bbeznd3r	215	23	NS2B	NS2B	NNP
cord-001734-bbeznd3r	215	24	(	(	-LRB-
cord-001734-bbeznd3r	215	25	48	48	CD
cord-001734-bbeznd3r	215	26	-	-	SYM
cord-001734-bbeznd3r	215	27	100	100	CD
cord-001734-bbeznd3r	215	28	)	)	-RRB-
cord-001734-bbeznd3r	215	29	in	in	IN
cord-001734-bbeznd3r	215	30	buffer	buffer	NN
cord-001734-bbeznd3r	215	31	,	,	,
cord-001734-bbeznd3r	215	32	implying	imply	VBG
cord-001734-bbeznd3r	215	33	that	that	IN
cord-001734-bbeznd3r	215	34	they	-PRON-	PRP
cord-001734-bbeznd3r	215	35	only	only	RB
cord-001734-bbeznd3r	215	36	have	have	VBP
cord-001734-bbeznd3r	215	37	a	a	DT
cord-001734-bbeznd3r	215	38	slight	slight	JJ
cord-001734-bbeznd3r	215	39	difference	difference	NN
cord-001734-bbeznd3r	215	40	in	in	IN
cord-001734-bbeznd3r	215	41	secondary	secondary	JJ
cord-001734-bbeznd3r	215	42	structures	structure	NNS
cord-001734-bbeznd3r	215	43	if	if	IN
cord-001734-bbeznd3r	215	44	considering	consider	VBG
cord-001734-bbeznd3r	215	45	the	the	DT
cord-001734-bbeznd3r	215	46	error	error	NN
cord-001734-bbeznd3r	215	47	in	in	IN
cord-001734-bbeznd3r	215	48	CD	cd	NN
cord-001734-bbeznd3r	215	49	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	215	50	.	.	.
cord-001734-bbeznd3r	216	1	On	on	IN
cord-001734-bbeznd3r	216	2	the	the	DT
cord-001734-bbeznd3r	216	3	other	other	JJ
cord-001734-bbeznd3r	216	4	hand	hand	NN
cord-001734-bbeznd3r	216	5	,	,	,
cord-001734-bbeznd3r	216	6	only	only	RB
cord-001734-bbeznd3r	216	7	a	a	DT
cord-001734-bbeznd3r	216	8	small	small	JJ
cord-001734-bbeznd3r	216	9	set	set	NN
cord-001734-bbeznd3r	216	10	of	of	IN
cord-001734-bbeznd3r	216	11	broad	broad	JJ
cord-001734-bbeznd3r	216	12	peaks	peak	NNS
cord-001734-bbeznd3r	216	13	could	could	MD
cord-001734-bbeznd3r	216	14	be	be	VB
cord-001734-bbeznd3r	216	15	detected	detect	VBN
cord-001734-bbeznd3r	216	16	in	in	IN
cord-001734-bbeznd3r	216	17	its	-PRON-	PRP$
cord-001734-bbeznd3r	216	18	HSQC	HSQC	NNP
cord-001734-bbeznd3r	216	19	spectrum	spectrum	NN
cord-001734-bbeznd3r	216	20	(	(	-LRB-
cord-001734-bbeznd3r	216	21	Fig	Fig	NNP
cord-001734-bbeznd3r	216	22	4B	4b	CD
cord-001734-bbeznd3r	216	23	)	)	-RRB-
cord-001734-bbeznd3r	216	24	,	,	,
cord-001734-bbeznd3r	216	25	indicating	indicate	VBG
cord-001734-bbeznd3r	216	26	that	that	IN
cord-001734-bbeznd3r	216	27	the	the	DT
cord-001734-bbeznd3r	216	28	NS3B	NS3B	NNP
cord-001734-bbeznd3r	216	29	(	(	-LRB-
cord-001734-bbeznd3r	216	30	1	1	CD
cord-001734-bbeznd3r	216	31	-	-	SYM
cord-001734-bbeznd3r	216	32	130	130	CD
cord-001734-bbeznd3r	216	33	)	)	-RRB-
cord-001734-bbeznd3r	216	34	in	in	IN
cord-001734-bbeznd3r	216	35	the	the	DT
cord-001734-bbeznd3r	216	36	LMPC	LMPC	NNP
cord-001734-bbeznd3r	216	37	micelle	micelle	NN
cord-001734-bbeznd3r	216	38	undergoes	undergo	VBZ
cord-001734-bbeznd3r	216	39	significant	significant	JJ
cord-001734-bbeznd3r	216	40	conformational	conformational	JJ
cord-001734-bbeznd3r	216	41	exchanges	exchange	NNS
cord-001734-bbeznd3r	216	42	on	on	IN
cord-001734-bbeznd3r	216	43	μs	μs	NNP
cord-001734-bbeznd3r	216	44	-	-	HYPH
cord-001734-bbeznd3r	216	45	ms	ms	NNP
cord-001734-bbeznd3r	216	46	time	time	NN
cord-001734-bbeznd3r	216	47	scale	scale	NN
cord-001734-bbeznd3r	216	48	,	,	,
cord-001734-bbeznd3r	216	49	or	or	CC
cord-001734-bbeznd3r	216	50	/	/	SYM
cord-001734-bbeznd3r	216	51	and	and	CC
cord-001734-bbeznd3r	216	52	dynamic	dynamic	JJ
cord-001734-bbeznd3r	216	53	aggregation	aggregation	NN
cord-001734-bbeznd3r	216	54	,	,	,
cord-001734-bbeznd3r	216	55	which	which	WDT
cord-001734-bbeznd3r	216	56	thus	thus	RB
cord-001734-bbeznd3r	216	57	prevents	prevent	VBZ
cord-001734-bbeznd3r	216	58	from	from	IN
cord-001734-bbeznd3r	216	59	further	further	JJ
cord-001734-bbeznd3r	216	60	high	high	JJ
cord-001734-bbeznd3r	216	61	-	-	HYPH
cord-001734-bbeznd3r	216	62	resolution	resolution	NN
cord-001734-bbeznd3r	216	63	NMR	NMR	NNP
cord-001734-bbeznd3r	216	64	studies	study	NNS
cord-001734-bbeznd3r	216	65	.	.	.
cord-001734-bbeznd3r	217	1	The	the	DT
cord-001734-bbeznd3r	217	2	observed	observed	JJ
cord-001734-bbeznd3r	217	3	line	line	NN
cord-001734-bbeznd3r	217	4	-	-	HYPH
cord-001734-bbeznd3r	217	5	broadening	broadening	NN
cord-001734-bbeznd3r	217	6	can	can	MD
cord-001734-bbeznd3r	217	7	not	not	RB
cord-001734-bbeznd3r	217	8	mainly	mainly	RB
cord-001734-bbeznd3r	217	9	result	result	VB
cord-001734-bbeznd3r	217	10	from	from	IN
cord-001734-bbeznd3r	217	11	the	the	DT
cord-001734-bbeznd3r	217	12	increased	increase	VBN
cord-001734-bbeznd3r	217	13	molecular	molecular	JJ
cord-001734-bbeznd3r	217	14	weight	weight	NN
cord-001734-bbeznd3r	217	15	in	in	IN
cord-001734-bbeznd3r	217	16	the	the	DT
cord-001734-bbeznd3r	217	17	LMPC	LMPC	NNP
cord-001734-bbeznd3r	217	18	micelle	micelle	NN
cord-001734-bbeznd3r	217	19	as	as	RB
cord-001734-bbeznd3r	217	20	much	much	RB
cord-001734-bbeznd3r	217	21	more	more	RBR
cord-001734-bbeznd3r	217	22	narrow	narrow	JJ
cord-001734-bbeznd3r	217	23	peaks	peak	NNS
cord-001734-bbeznd3r	217	24	for	for	IN
cord-001734-bbeznd3r	217	25	almost	almost	RB
cord-001734-bbeznd3r	217	26	all	all	DT
cord-001734-bbeznd3r	217	27	residues	residue	NNS
cord-001734-bbeznd3r	217	28	could	could	MD
cord-001734-bbeznd3r	217	29	be	be	VB
cord-001734-bbeznd3r	217	30	detected	detect	VBN
cord-001734-bbeznd3r	217	31	for	for	IN
cord-001734-bbeznd3r	217	32	the	the	DT
cord-001734-bbeznd3r	217	33	helical	helical	JJ
cord-001734-bbeznd3r	217	34	superoxide	superoxide	NN
cord-001734-bbeznd3r	217	35	dismutase	dismutase	NN
cord-001734-bbeznd3r	217	36	1	1	CD
cord-001734-bbeznd3r	217	37	(	(	-LRB-
cord-001734-bbeznd3r	217	38	SOD1	SOD1	NNP
cord-001734-bbeznd3r	217	39	)	)	-RRB-
cord-001734-bbeznd3r	217	40	with	with	IN
cord-001734-bbeznd3r	217	41	153	153	CD
cord-001734-bbeznd3r	217	42	residues	residue	NNS
cord-001734-bbeznd3r	217	43	in	in	IN
cord-001734-bbeznd3r	217	44	the	the	DT
cord-001734-bbeznd3r	217	45	DPC	DPC	NNP
cord-001734-bbeznd3r	217	46	micelle	micelle	NN
cord-001734-bbeznd3r	217	47	[	[	-LRB-
cord-001734-bbeznd3r	217	48	41	41	CD
cord-001734-bbeznd3r	217	49	]	]	-RRB-
cord-001734-bbeznd3r	217	50	.	.	.
cord-001734-bbeznd3r	218	1	We	-PRON-	PRP
cord-001734-bbeznd3r	218	2	also	also	RB
cord-001734-bbeznd3r	218	3	refolded	refolde	VBD
cord-001734-bbeznd3r	218	4	the	the	DT
cord-001734-bbeznd3r	218	5	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	218	6	with	with	IN
cord-001734-bbeznd3r	218	7	the	the	DT
cord-001734-bbeznd3r	218	8	full	full	JJ
cord-001734-bbeznd3r	218	9	-	-	HYPH
cord-001734-bbeznd3r	218	10	length	length	NN
cord-001734-bbeznd3r	218	11	NS2B	NS2B	NNP
cord-001734-bbeznd3r	218	12	(	(	-LRB-
cord-001734-bbeznd3r	218	13	1	1	CD
cord-001734-bbeznd3r	218	14	-	-	SYM
cord-001734-bbeznd3r	218	15	130	130	CD
cord-001734-bbeznd3r	218	16	)	)	-RRB-
cord-001734-bbeznd3r	218	17	in	in	IN
cord-001734-bbeznd3r	218	18	the	the	DT
cord-001734-bbeznd3r	218	19	LMPC	LMPC	NNP
cord-001734-bbeznd3r	218	20	micelle	micelle	NN
cord-001734-bbeznd3r	218	21	.	.	.
cord-001734-bbeznd3r	219	1	As	as	IN
cord-001734-bbeznd3r	219	2	shown	show	VBN
cord-001734-bbeznd3r	219	3	in	in	IN
cord-001734-bbeznd3r	219	4	Fig	Fig	NNP
cord-001734-bbeznd3r	219	5	4A	4a	CD
cord-001734-bbeznd3r	219	6	,	,	,
cord-001734-bbeznd3r	219	7	the	the	DT
cord-001734-bbeznd3r	219	8	far	far	JJ
cord-001734-bbeznd3r	219	9	-	-	HYPH
cord-001734-bbeznd3r	219	10	UV	uv	NN
cord-001734-bbeznd3r	219	11	CD	cd	NN
cord-001734-bbeznd3r	219	12	spectrum	spectrum	NN
cord-001734-bbeznd3r	219	13	of	of	IN
cord-001734-bbeznd3r	219	14	the	the	DT
cord-001734-bbeznd3r	219	15	complex	complex	NN
cord-001734-bbeznd3r	219	16	between	between	IN
cord-001734-bbeznd3r	219	17	NS2B	NS2B	NNP
cord-001734-bbeznd3r	219	18	(	(	-LRB-
cord-001734-bbeznd3r	219	19	1	1	CD
cord-001734-bbeznd3r	219	20	-	-	SYM
cord-001734-bbeznd3r	219	21	130	130	CD
cord-001734-bbeznd3r	219	22	)	)	-RRB-
cord-001734-bbeznd3r	219	23	and	and	CC
cord-001734-bbeznd3r	219	24	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	219	25	in	in	IN
cord-001734-bbeznd3r	219	26	the	the	DT
cord-001734-bbeznd3r	219	27	LMPC	LMPC	NNP
cord-001734-bbeznd3r	219	28	micelle	micelle	NN
cord-001734-bbeznd3r	219	29	has	have	VBZ
cord-001734-bbeznd3r	219	30	the	the	DT
cord-001734-bbeznd3r	219	31	maximal	maximal	JJ
cord-001734-bbeznd3r	219	32	negative	negative	JJ
cord-001734-bbeznd3r	219	33	signal	signal	NN
cord-001734-bbeznd3r	219	34	at	at	IN
cord-001734-bbeznd3r	219	35	206	206	CD
cord-001734-bbeznd3r	219	36	nm	nm	NN
cord-001734-bbeznd3r	219	37	and	and	CC
cord-001734-bbeznd3r	219	38	positive	positive	JJ
cord-001734-bbeznd3r	219	39	signal	signal	NN
cord-001734-bbeznd3r	219	40	at	at	IN
cord-001734-bbeznd3r	219	41	190	190	CD
cord-001734-bbeznd3r	219	42	nm	nm	NN
cord-001734-bbeznd3r	219	43	,	,	,
cord-001734-bbeznd3r	219	44	as	as	RB
cord-001734-bbeznd3r	219	45	well	well	RB
cord-001734-bbeznd3r	219	46	as	as	IN
cord-001734-bbeznd3r	219	47	an	an	DT
cord-001734-bbeznd3r	219	48	additional	additional	JJ
cord-001734-bbeznd3r	219	49	negative	negative	JJ
cord-001734-bbeznd3r	219	50	signal	signal	NN
cord-001734-bbeznd3r	219	51	at	at	IN
cord-001734-bbeznd3r	219	52	222	222	CD
cord-001734-bbeznd3r	219	53	nm	nm	NN
cord-001734-bbeznd3r	219	54	(	(	-LRB-
cord-001734-bbeznd3r	219	55	Fig	fig	NN
cord-001734-bbeznd3r	219	56	4A	4a	CD
cord-001734-bbeznd3r	219	57	)	)	-RRB-
cord-001734-bbeznd3r	219	58	.	.	.
cord-001734-bbeznd3r	220	1	The	the	DT
cord-001734-bbeznd3r	220	2	deconvolution	deconvolution	NN
cord-001734-bbeznd3r	220	3	shows	show	VBZ
cord-001734-bbeznd3r	220	4	that	that	IN
cord-001734-bbeznd3r	220	5	its	-PRON-	PRP$
cord-001734-bbeznd3r	220	6	secondary	secondary	JJ
cord-001734-bbeznd3r	220	7	structure	structure	NN
cord-001734-bbeznd3r	220	8	contents	content	NNS
cord-001734-bbeznd3r	220	9	are	be	VBP
cord-001734-bbeznd3r	220	10	very	very	RB
cord-001734-bbeznd3r	220	11	similar	similar	JJ
cord-001734-bbeznd3r	220	12	to	to	IN
cord-001734-bbeznd3r	220	13	those	those	DT
cord-001734-bbeznd3r	220	14	of	of	IN
cord-001734-bbeznd3r	220	15	the	the	DT
cord-001734-bbeznd3r	220	16	complex	complex	NN
cord-001734-bbeznd3r	220	17	between	between	IN
cord-001734-bbeznd3r	220	18	NS2B	NS2B	NNP
cord-001734-bbeznd3r	220	19	(	(	-LRB-
cord-001734-bbeznd3r	220	20	48	48	CD
cord-001734-bbeznd3r	220	21	-	-	SYM
cord-001734-bbeznd3r	220	22	100	100	CD
cord-001734-bbeznd3r	220	23	)	)	-RRB-
cord-001734-bbeznd3r	220	24	and	and	CC
cord-001734-bbeznd3r	220	25	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	220	26	in	in	IN
cord-001734-bbeznd3r	220	27	buffer	buffer	NN
cord-001734-bbeznd3r	220	28	,	,	,
cord-001734-bbeznd3r	220	29	only	only	RB
cord-001734-bbeznd3r	220	30	with~3	with~3	NNP
cord-001734-bbeznd3r	220	31	%	%	NN
cord-001734-bbeznd3r	220	32	increase	increase	NN
cord-001734-bbeznd3r	220	33	of	of	IN
cord-001734-bbeznd3r	220	34	β	β	NN
cord-001734-bbeznd3r	220	35	-	-	HYPH
cord-001734-bbeznd3r	220	36	strand	strand	NN
cord-001734-bbeznd3r	220	37	conformation	conformation	NN
cord-001734-bbeznd3r	220	38	and~1.6	and~1.6	VBD
cord-001734-bbeznd3r	220	39	%	%	NN
cord-001734-bbeznd3r	220	40	reduction	reduction	NN
cord-001734-bbeznd3r	220	41	of	of	IN
cord-001734-bbeznd3r	220	42	the	the	DT
cord-001734-bbeznd3r	220	43	helix	helix	NN
cord-001734-bbeznd3r	220	44	conformation	conformation	NN
cord-001734-bbeznd3r	220	45	.	.	.
cord-001734-bbeznd3r	221	1	However	however	RB
cord-001734-bbeznd3r	221	2	,	,	,
cord-001734-bbeznd3r	221	3	very	very	RB
cord-001734-bbeznd3r	221	4	different	different	JJ
cord-001734-bbeznd3r	221	5	from	from	IN
cord-001734-bbeznd3r	221	6	the	the	DT
cord-001734-bbeznd3r	221	7	complex	complex	NN
cord-001734-bbeznd3r	221	8	between	between	IN
cord-001734-bbeznd3r	221	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	221	10	(	(	-LRB-
cord-001734-bbeznd3r	221	11	48	48	CD
cord-001734-bbeznd3r	221	12	-	-	SYM
cord-001734-bbeznd3r	221	13	100	100	CD
cord-001734-bbeznd3r	221	14	)	)	-RRB-
cord-001734-bbeznd3r	221	15	and	and	CC
cord-001734-bbeznd3r	221	16	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	221	17	in	in	IN
cord-001734-bbeznd3r	221	18	buffer	buffer	NN
cord-001734-bbeznd3r	221	19	(	(	-LRB-
cord-001734-bbeznd3r	221	20	Fig	Fig	NNP
cord-001734-bbeznd3r	221	21	3D	3D	NNP
cord-001734-bbeznd3r	221	22	)	)	-RRB-
cord-001734-bbeznd3r	221	23	,	,	,
cord-001734-bbeznd3r	221	24	for	for	IN
cord-001734-bbeznd3r	221	25	the	the	DT
cord-001734-bbeznd3r	221	26	HSQC	HSQC	NNP
cord-001734-bbeznd3r	221	27	spectrum	spectrum	NN
cord-001734-bbeznd3r	221	28	of	of	IN
cord-001734-bbeznd3r	221	29	the	the	DT
cord-001734-bbeznd3r	221	30	complex	complex	NN
cord-001734-bbeznd3r	221	31	between	between	IN
cord-001734-bbeznd3r	221	32	NS2B	NS2B	NNP
cord-001734-bbeznd3r	221	33	(	(	-LRB-
cord-001734-bbeznd3r	221	34	1	1	CD
cord-001734-bbeznd3r	221	35	-	-	SYM
cord-001734-bbeznd3r	221	36	130	130	CD
cord-001734-bbeznd3r	221	37	)	)	-RRB-
cord-001734-bbeznd3r	221	38	and	and	CC
cord-001734-bbeznd3r	221	39	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	221	40	in	in	IN
cord-001734-bbeznd3r	221	41	the	the	DT
cord-001734-bbeznd3r	221	42	LMPC	LMPC	NNP
cord-001734-bbeznd3r	221	43	micelle	micelle	NN
cord-001734-bbeznd3r	221	44	(	(	-LRB-
cord-001734-bbeznd3r	221	45	Fig	Fig	NNP
cord-001734-bbeznd3r	221	46	4C	4c	CD
cord-001734-bbeznd3r	221	47	)	)	-RRB-
cord-001734-bbeznd3r	221	48	,	,	,
cord-001734-bbeznd3r	221	49	only	only	RB
cord-001734-bbeznd3r	221	50	a	a	DT
cord-001734-bbeznd3r	221	51	small	small	JJ
cord-001734-bbeznd3r	221	52	portion	portion	NN
cord-001734-bbeznd3r	221	53	of	of	IN
cord-001734-bbeznd3r	221	54	the	the	DT
cord-001734-bbeznd3r	221	55	HSQC	HSQC	NNP
cord-001734-bbeznd3r	221	56	resonance	resonance	NN
cord-001734-bbeznd3r	221	57	peaks	peak	NNS
cord-001734-bbeznd3r	221	58	could	could	MD
cord-001734-bbeznd3r	221	59	be	be	VB
cord-001734-bbeznd3r	221	60	observed	observe	VBN
cord-001734-bbeznd3r	221	61	,	,	,
cord-001734-bbeznd3r	221	62	which	which	WDT
cord-001734-bbeznd3r	221	63	are	be	VBP
cord-001734-bbeznd3r	221	64	also	also	RB
cord-001734-bbeznd3r	221	65	much	much	RB
cord-001734-bbeznd3r	221	66	more	more	RBR
cord-001734-bbeznd3r	221	67	broad	broad	JJ
cord-001734-bbeznd3r	221	68	.	.	.
cord-001734-bbeznd3r	222	1	This	this	DT
cord-001734-bbeznd3r	222	2	is	be	VBZ
cord-001734-bbeznd3r	222	3	partly	partly	RB
cord-001734-bbeznd3r	222	4	due	due	JJ
cord-001734-bbeznd3r	222	5	to	to	IN
cord-001734-bbeznd3r	222	6	the	the	DT
cord-001734-bbeznd3r	222	7	increased	increase	VBN
cord-001734-bbeznd3r	222	8	molecular	molecular	JJ
cord-001734-bbeznd3r	222	9	weight	weight	NN
cord-001734-bbeznd3r	222	10	of	of	IN
cord-001734-bbeznd3r	222	11	the	the	DT
cord-001734-bbeznd3r	222	12	complex	complex	NN
cord-001734-bbeznd3r	222	13	upon	upon	IN
cord-001734-bbeznd3r	222	14	being	be	VBG
cord-001734-bbeznd3r	222	15	anchored	anchor	VBN
cord-001734-bbeznd3r	222	16	into	into	IN
cord-001734-bbeznd3r	222	17	the	the	DT
cord-001734-bbeznd3r	222	18	LMPC	LMPC	NNP
cord-001734-bbeznd3r	222	19	micelle	micelle	NN
cord-001734-bbeznd3r	222	20	.	.	.
cord-001734-bbeznd3r	223	1	A	a	DT
cord-001734-bbeznd3r	223	2	closer	close	JJR
cord-001734-bbeznd3r	223	3	examination	examination	NN
cord-001734-bbeznd3r	223	4	of	of	IN
cord-001734-bbeznd3r	223	5	the	the	DT
cord-001734-bbeznd3r	223	6	spectra	spectra	NN
cord-001734-bbeznd3r	223	7	revealed	reveal	VBD
cord-001734-bbeznd3r	223	8	that	that	IN
cord-001734-bbeznd3r	223	9	a	a	DT
cord-001734-bbeznd3r	223	10	small	small	JJ
cord-001734-bbeznd3r	223	11	set	set	NN
cord-001734-bbeznd3r	223	12	of	of	IN
cord-001734-bbeznd3r	223	13	the	the	DT
cord-001734-bbeznd3r	223	14	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	223	15	HSQC	HSQC	NNP
cord-001734-bbeznd3r	223	16	peaks	peak	NNS
cord-001734-bbeznd3r	223	17	of	of	IN
cord-001734-bbeznd3r	223	18	the	the	DT
cord-001734-bbeznd3r	223	19	NS2B	NS2B	NNP
cord-001734-bbeznd3r	223	20	(	(	-LRB-
cord-001734-bbeznd3r	223	21	1	1	CD
cord-001734-bbeznd3r	223	22	-	-	HYPH
cord-001734-bbeznd3r	223	23	130)-NS3pro	130)-ns3pro	CD
cord-001734-bbeznd3r	223	24	complex	complex	NN
cord-001734-bbeznd3r	223	25	in	in	IN
cord-001734-bbeznd3r	223	26	the	the	DT
cord-001734-bbeznd3r	223	27	LMPC	LMPC	NNP
cord-001734-bbeznd3r	223	28	micelle	micelle	NN
cord-001734-bbeznd3r	223	29	is	be	VBZ
cord-001734-bbeznd3r	223	30	almost	almost	RB
cord-001734-bbeznd3r	223	31	superimposable	superimposable	JJ
cord-001734-bbeznd3r	223	32	to	to	IN
cord-001734-bbeznd3r	223	33	those	those	DT
cord-001734-bbeznd3r	223	34	of	of	IN
cord-001734-bbeznd3r	223	35	the	the	DT
cord-001734-bbeznd3r	223	36	NS2B	NS2B	NNP
cord-001734-bbeznd3r	223	37	(	(	-LRB-
cord-001734-bbeznd3r	223	38	40	40	CD
cord-001734-bbeznd3r	223	39	-	-	SYM
cord-001734-bbeznd3r	223	40	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	223	41	complex	complex	NN
cord-001734-bbeznd3r	223	42	.	.	.
cord-001734-bbeznd3r	224	1	These	these	DT
cord-001734-bbeznd3r	224	2	residues	residue	NNS
cord-001734-bbeznd3r	224	3	were	be	VBD
cord-001734-bbeznd3r	224	4	identified	identify	VBN
cord-001734-bbeznd3r	224	5	to	to	TO
cord-001734-bbeznd3r	224	6	be	be	VB
cord-001734-bbeznd3r	224	7	the	the	DT
cord-001734-bbeznd3r	224	8	C	c	NN
cord-001734-bbeznd3r	224	9	-	-	HYPH
cord-001734-bbeznd3r	224	10	terminal	terminal	NN
cord-001734-bbeznd3r	224	11	residues	residue	NNS
cord-001734-bbeznd3r	224	12	Glu173-Lys185	Glu173-Lys185	NNP
cord-001734-bbeznd3r	224	13	of	of	IN
cord-001734-bbeznd3r	224	14	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	224	15	,	,	,
cord-001734-bbeznd3r	224	16	which	which	WDT
cord-001734-bbeznd3r	224	17	were	be	VBD
cord-001734-bbeznd3r	224	18	not	not	RB
cord-001734-bbeznd3r	224	19	visible	visible	JJ
cord-001734-bbeznd3r	224	20	in	in	IN
cord-001734-bbeznd3r	224	21	crystal	crystal	JJ
cord-001734-bbeznd3r	224	22	structures	structure	NNS
cord-001734-bbeznd3r	224	23	of	of	IN
cord-001734-bbeznd3r	224	24	the	the	DT
cord-001734-bbeznd3r	224	25	NS2B	NS2B	NNP
cord-001734-bbeznd3r	224	26	-	-	HYPH
cord-001734-bbeznd3r	224	27	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	224	28	complexes	complex	NNS
cord-001734-bbeznd3r	224	29	,	,	,
cord-001734-bbeznd3r	224	30	thus	thus	RB
cord-001734-bbeznd3r	224	31	suggesting	suggest	VBG
cord-001734-bbeznd3r	224	32	that	that	IN
cord-001734-bbeznd3r	224	33	they	-PRON-	PRP
cord-001734-bbeznd3r	224	34	are	be	VBP
cord-001734-bbeznd3r	224	35	similarly	similarly	RB
cord-001734-bbeznd3r	224	36	flexible	flexible	JJ
cord-001734-bbeznd3r	224	37	in	in	IN
cord-001734-bbeznd3r	224	38	both	both	DT
cord-001734-bbeznd3r	224	39	complexes	complex	NNS
cord-001734-bbeznd3r	225	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	225	2	(	(	-LRB-
cord-001734-bbeznd3r	225	3	40	40	CD
cord-001734-bbeznd3r	225	4	-	-	SYM
cord-001734-bbeznd3r	225	5	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	225	6	in	in	IN
cord-001734-bbeznd3r	225	7	buffer	buffer	NN
cord-001734-bbeznd3r	225	8	and	and	CC
cord-001734-bbeznd3r	226	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	226	2	(	(	-LRB-
cord-001734-bbeznd3r	226	3	1	1	CD
cord-001734-bbeznd3r	226	4	-	-	SYM
cord-001734-bbeznd3r	226	5	130)-NS3pro	130)-ns3pro	CD
cord-001734-bbeznd3r	226	6	in	in	IN
cord-001734-bbeznd3r	226	7	the	the	DT
cord-001734-bbeznd3r	226	8	LMPC	LMPC	NNP
cord-001734-bbeznd3r	226	9	micelle	micelle	NN
cord-001734-bbeznd3r	226	10	)	)	-RRB-
cord-001734-bbeznd3r	226	11	.	.	.
cord-001734-bbeznd3r	227	1	On	on	IN
cord-001734-bbeznd3r	227	2	the	the	DT
cord-001734-bbeznd3r	227	3	other	other	JJ
cord-001734-bbeznd3r	227	4	hand	hand	NN
cord-001734-bbeznd3r	227	5	,	,	,
cord-001734-bbeznd3r	227	6	some	some	DT
cord-001734-bbeznd3r	227	7	HSQC	HSQC	NNP
cord-001734-bbeznd3r	227	8	peaks	peak	NNS
cord-001734-bbeznd3r	227	9	of	of	IN
cord-001734-bbeznd3r	227	10	the	the	DT
cord-001734-bbeznd3r	227	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	227	12	domain	domain	NN
cord-001734-bbeznd3r	227	13	complexed	complexe	VBN
cord-001734-bbeznd3r	227	14	with	with	IN
cord-001734-bbeznd3r	227	15	the	the	DT
cord-001734-bbeznd3r	227	16	NS2B	NS2B	NNP
cord-001734-bbeznd3r	227	17	(	(	-LRB-
cord-001734-bbeznd3r	227	18	1	1	CD
cord-001734-bbeznd3r	227	19	-	-	SYM
cord-001734-bbeznd3r	227	20	130	130	CD
cord-001734-bbeznd3r	227	21	)	)	-RRB-
cord-001734-bbeznd3r	227	22	in	in	IN
cord-001734-bbeznd3r	227	23	the	the	DT
cord-001734-bbeznd3r	227	24	LMPC	LMPC	NNP
cord-001734-bbeznd3r	227	25	micelle	micelle	NN
cord-001734-bbeznd3r	227	26	are	be	VBP
cord-001734-bbeznd3r	227	27	not	not	RB
cord-001734-bbeznd3r	227	28	superimposable	superimposable	JJ
cord-001734-bbeznd3r	227	29	to	to	IN
cord-001734-bbeznd3r	227	30	those	those	DT
cord-001734-bbeznd3r	227	31	in	in	IN
cord-001734-bbeznd3r	227	32	the	the	DT
cord-001734-bbeznd3r	227	33	NS2B	NS2B	NNP
cord-001734-bbeznd3r	227	34	(	(	-LRB-
cord-001734-bbeznd3r	227	35	40	40	CD
cord-001734-bbeznd3r	227	36	-	-	SYM
cord-001734-bbeznd3r	227	37	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	227	38	complex	complex	NN
cord-001734-bbeznd3r	227	39	.	.	.
cord-001734-bbeznd3r	228	1	This	this	DT
cord-001734-bbeznd3r	228	2	implies	imply	VBZ
cord-001734-bbeznd3r	228	3	that	that	IN
cord-001734-bbeznd3r	228	4	these	these	DT
cord-001734-bbeznd3r	228	5	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	228	6	residues	residue	NNS
cord-001734-bbeznd3r	228	7	may	may	MD
cord-001734-bbeznd3r	228	8	have	have	VB
cord-001734-bbeznd3r	228	9	different	different	JJ
cord-001734-bbeznd3r	228	10	structures	structure	NNS
cord-001734-bbeznd3r	228	11	,	,	,
cord-001734-bbeznd3r	228	12	or	or	CC
cord-001734-bbeznd3r	228	13	/	/	SYM
cord-001734-bbeznd3r	228	14	and	and	CC
cord-001734-bbeznd3r	228	15	dynamics	dynamic	NNS
cord-001734-bbeznd3r	228	16	,	,	,
cord-001734-bbeznd3r	228	17	or	or	CC
cord-001734-bbeznd3r	228	18	/	/	SYM
cord-001734-bbeznd3r	228	19	and	and	CC
cord-001734-bbeznd3r	228	20	chemical	chemical	NN
cord-001734-bbeznd3r	228	21	environments	environment	NNS
cord-001734-bbeznd3r	228	22	in	in	IN
cord-001734-bbeznd3r	228	23	the	the	DT
cord-001734-bbeznd3r	228	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	228	25	(	(	-LRB-
cord-001734-bbeznd3r	228	26	40	40	CD
cord-001734-bbeznd3r	228	27	-	-	SYM
cord-001734-bbeznd3r	228	28	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	228	29	and	and	CC
cord-001734-bbeznd3r	228	30	NS2B	NS2B	NNP
cord-001734-bbeznd3r	229	1	(	(	-LRB-
cord-001734-bbeznd3r	229	2	1	1	CD
cord-001734-bbeznd3r	229	3	-	-	SYM
cord-001734-bbeznd3r	229	4	130)-NS3pro	130)-ns3pro	CD
cord-001734-bbeznd3r	229	5	in	in	IN
cord-001734-bbeznd3r	229	6	the	the	DT
cord-001734-bbeznd3r	229	7	LMPC	LMPC	NNP
cord-001734-bbeznd3r	229	8	micelle	micelle	NN
cord-001734-bbeznd3r	229	9	.	.	.
cord-001734-bbeznd3r	230	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	230	2	the	the	DT
cord-001734-bbeznd3r	230	3	fact	fact	NN
cord-001734-bbeznd3r	230	4	that	that	IN
cord-001734-bbeznd3r	230	5	most	most	RBS
cord-001734-bbeznd3r	230	6	well	well	RB
cord-001734-bbeznd3r	230	7	-	-	HYPH
cord-001734-bbeznd3r	230	8	dispersed	disperse	VBN
cord-001734-bbeznd3r	230	9	HSQC	HSQC	NNP
cord-001734-bbeznd3r	230	10	peaks	peak	NNS
cord-001734-bbeznd3r	230	11	disappeared	disappear	VBD
cord-001734-bbeznd3r	230	12	(	(	-LRB-
cord-001734-bbeznd3r	230	13	Fig	Fig	NNP
cord-001734-bbeznd3r	230	14	4C	4c	CD
cord-001734-bbeznd3r	230	15	)	)	-RRB-
cord-001734-bbeznd3r	230	16	implies	imply	VBZ
cord-001734-bbeznd3r	230	17	that	that	IN
cord-001734-bbeznd3r	230	18	the	the	DT
cord-001734-bbeznd3r	230	19	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	230	20	may	may	MD
cord-001734-bbeznd3r	230	21	undergoes	undergo	VBZ
cord-001734-bbeznd3r	230	22	significant	significant	JJ
cord-001734-bbeznd3r	230	23	conformational	conformational	JJ
cord-001734-bbeznd3r	230	24	exchanges	exchange	NNS
cord-001734-bbeznd3r	230	25	on	on	IN
cord-001734-bbeznd3r	230	26	μs	μs	NNP
cord-001734-bbeznd3r	230	27	-	-	HYPH
cord-001734-bbeznd3r	230	28	ms	ms	NNP
cord-001734-bbeznd3r	230	29	time	time	NN
cord-001734-bbeznd3r	230	30	scale	scale	NN
cord-001734-bbeznd3r	230	31	upon	upon	IN
cord-001734-bbeznd3r	230	32	being	be	VBG
cord-001734-bbeznd3r	230	33	anchored	anchor	VBN
cord-001734-bbeznd3r	230	34	in	in	IN
cord-001734-bbeznd3r	230	35	the	the	DT
cord-001734-bbeznd3r	230	36	LMPC	LMPC	NNP
cord-001734-bbeznd3r	230	37	micelle	micelle	NN
cord-001734-bbeznd3r	230	38	.	.	.
cord-001734-bbeznd3r	231	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	231	2	,	,	,
cord-001734-bbeznd3r	231	3	the	the	DT
cord-001734-bbeznd3r	231	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	231	5	(	(	-LRB-
cord-001734-bbeznd3r	231	6	1	1	CD
cord-001734-bbeznd3r	231	7	-	-	SYM
cord-001734-bbeznd3r	231	8	130)-NS3pro	130)-ns3pro	CD
cord-001734-bbeznd3r	231	9	in	in	IN
cord-001734-bbeznd3r	231	10	the	the	DT
cord-001734-bbeznd3r	231	11	LMPC	LMPC	NNP
cord-001734-bbeznd3r	231	12	micelle	micelle	NN
cord-001734-bbeznd3r	231	13	is	be	VBZ
cord-001734-bbeznd3r	231	14	similarly	similarly	RB
cord-001734-bbeznd3r	231	15	active	active	JJ
cord-001734-bbeznd3r	231	16	,	,	,
cord-001734-bbeznd3r	231	17	with	with	IN
cord-001734-bbeznd3r	231	18	Km	km	NN
cord-001734-bbeznd3r	231	19	=	=	SYM
cord-001734-bbeznd3r	231	20	101.1	101.1	CD
cord-001734-bbeznd3r	231	21	±	±	CD
cord-001734-bbeznd3r	231	22	3.163	3.163	CD
cord-001734-bbeznd3r	231	23	μM	μM	NNP
cord-001734-bbeznd3r	231	24	and	and	CC
cord-001734-bbeznd3r	231	25	Kcat	Kcat	NNP
cord-001734-bbeznd3r	231	26	=	=	SYM
cord-001734-bbeznd3r	231	27	0.2469	0.2469	CD
cord-001734-bbeznd3r	231	28	±	±	NNP
cord-001734-bbeznd3r	231	29	0.003	0.003	NN
cord-001734-bbeznd3r	231	30	s	s	NNP
cord-001734-bbeznd3r	231	31	-1	-1	NN
cord-001734-bbeznd3r	231	32	,	,	,
cord-001734-bbeznd3r	231	33	which	which	WDT
cord-001734-bbeznd3r	231	34	are	be	VBP
cord-001734-bbeznd3r	231	35	very	very	RB
cord-001734-bbeznd3r	231	36	similar	similar	JJ
cord-001734-bbeznd3r	231	37	to	to	IN
cord-001734-bbeznd3r	231	38	the	the	DT
cord-001734-bbeznd3r	231	39	activity	activity	NN
cord-001734-bbeznd3r	231	40	of	of	IN
cord-001734-bbeznd3r	231	41	the	the	DT
cord-001734-bbeznd3r	231	42	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	231	43	in	in	IN
cord-001734-bbeznd3r	231	44	complex	complex	NN
cord-001734-bbeznd3r	231	45	with	with	IN
cord-001734-bbeznd3r	231	46	the	the	DT
cord-001734-bbeznd3r	231	47	NS2B	NS2B	NNP
cord-001734-bbeznd3r	231	48	(	(	-LRB-
cord-001734-bbeznd3r	231	49	48	48	CD
cord-001734-bbeznd3r	231	50	-	-	SYM
cord-001734-bbeznd3r	231	51	100	100	CD
cord-001734-bbeznd3r	231	52	)	)	-RRB-
cord-001734-bbeznd3r	231	53	with	with	IN
cord-001734-bbeznd3r	231	54	transmembrane	transmembrane	NNP
cord-001734-bbeznd3r	231	55	regions	region	NNS
cord-001734-bbeznd3r	231	56	deleted	delete	VBN
cord-001734-bbeznd3r	231	57	.	.	.
cord-001734-bbeznd3r	232	1	Molecular	molecular	JJ
cord-001734-bbeznd3r	232	2	dynamics	dynamic	NNS
cord-001734-bbeznd3r	232	3	simulation	simulation	NN
cord-001734-bbeznd3r	232	4	is	be	VBZ
cord-001734-bbeznd3r	232	5	a	a	DT
cord-001734-bbeznd3r	232	6	powerful	powerful	JJ
cord-001734-bbeznd3r	232	7	tool	tool	NN
cord-001734-bbeznd3r	232	8	to	to	TO
cord-001734-bbeznd3r	232	9	gain	gain	VB
cord-001734-bbeznd3r	232	10	insights	insight	NNS
cord-001734-bbeznd3r	232	11	into	into	IN
cord-001734-bbeznd3r	232	12	protein	protein	NN
cord-001734-bbeznd3r	232	13	dynamics	dynamic	NNS
cord-001734-bbeznd3r	232	14	and	and	CC
cord-001734-bbeznd3r	232	15	folding	folding	NN
cord-001734-bbeznd3r	232	16	/	/	SYM
cord-001734-bbeznd3r	232	17	unfolding	unfolding	NN
cord-001734-bbeznd3r	232	18	that	that	WDT
cord-001734-bbeznd3r	232	19	underlies	underlie	VBZ
cord-001734-bbeznd3r	232	20	protein	protein	NN
cord-001734-bbeznd3r	232	21	functions	function	NNS
cord-001734-bbeznd3r	232	22	.	.	.
cord-001734-bbeznd3r	233	1	Although	although	IN
cord-001734-bbeznd3r	233	2	it	-PRON-	PRP
cord-001734-bbeznd3r	233	3	remains	remain	VBZ
cord-001734-bbeznd3r	233	4	extremely	extremely	RB
cord-001734-bbeznd3r	233	5	challenging	challenging	JJ
cord-001734-bbeznd3r	233	6	to	to	TO
cord-001734-bbeznd3r	233	7	simulate	simulate	VB
cord-001734-bbeznd3r	233	8	the	the	DT
cord-001734-bbeznd3r	233	9	folding	folding	NN
cord-001734-bbeznd3r	233	10	/	/	SYM
cord-001734-bbeznd3r	233	11	unfolding	unfold	VBG
cord-001734-bbeznd3r	233	12	for	for	IN
cord-001734-bbeznd3r	233	13	large	large	JJ
cord-001734-bbeznd3r	233	14	proteins	protein	NNS
cord-001734-bbeznd3r	233	15	such	such	JJ
cord-001734-bbeznd3r	233	16	as	as	IN
cord-001734-bbeznd3r	233	17	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	233	18	,	,	,
cord-001734-bbeznd3r	233	19	which	which	WDT
cord-001734-bbeznd3r	233	20	usually	usually	RB
cord-001734-bbeznd3r	233	21	occurs	occur	VBZ
cord-001734-bbeznd3r	233	22	on	on	IN
cord-001734-bbeznd3r	233	23	the	the	DT
cord-001734-bbeznd3r	233	24	ms	ms	NNP
cord-001734-bbeznd3r	233	25	-	-	HYPH
cord-001734-bbeznd3r	233	26	s	s	NNP
cord-001734-bbeznd3r	233	27	time	time	NN
cord-001734-bbeznd3r	233	28	scale	scale	NN
cord-001734-bbeznd3r	233	29	,	,	,
cord-001734-bbeznd3r	233	30	short	short	JJ
cord-001734-bbeznd3r	233	31	MD	MD	NNP
cord-001734-bbeznd3r	233	32	simulations	simulation	NNS
cord-001734-bbeznd3r	233	33	in	in	IN
cord-001734-bbeznd3r	233	34	conjunction	conjunction	NN
cord-001734-bbeznd3r	233	35	with	with	IN
cord-001734-bbeznd3r	233	36	the	the	DT
cord-001734-bbeznd3r	233	37	correlation	correlation	NN
cord-001734-bbeznd3r	233	38	analysis	analysis	NN
cord-001734-bbeznd3r	233	39	are	be	VBP
cord-001734-bbeznd3r	233	40	able	able	JJ
cord-001734-bbeznd3r	233	41	to	to	TO
cord-001734-bbeznd3r	233	42	capture	capture	VB
cord-001734-bbeznd3r	233	43	the	the	DT
cord-001734-bbeznd3r	233	44	low	low	JJ
cord-001734-bbeznd3r	233	45	-	-	HYPH
cord-001734-bbeznd3r	233	46	frequency	frequency	NN
cord-001734-bbeznd3r	233	47	correlated	correlate	VBN
cord-001734-bbeznd3r	233	48	motions	motion	NNS
cord-001734-bbeznd3r	233	49	,	,	,
cord-001734-bbeznd3r	233	50	which	which	WDT
cord-001734-bbeznd3r	233	51	have	have	VBP
cord-001734-bbeznd3r	233	52	been	be	VBN
cord-001734-bbeznd3r	233	53	recently	recently	RB
cord-001734-bbeznd3r	233	54	found	find	VBN
cord-001734-bbeznd3r	233	55	to	to	TO
cord-001734-bbeznd3r	233	56	be	be	VB
cord-001734-bbeznd3r	233	57	essential	essential	JJ
cord-001734-bbeznd3r	233	58	for	for	IN
cord-001734-bbeznd3r	233	59	the	the	DT
cord-001734-bbeznd3r	233	60	catalysis	catalysis	NN
cord-001734-bbeznd3r	233	61	of	of	IN
cord-001734-bbeznd3r	233	62	the	the	DT
cord-001734-bbeznd3r	233	63	SARS	SARS	NNP
cord-001734-bbeznd3r	233	64	3C	3C	NNP
cord-001734-bbeznd3r	233	65	-	-	HYPH
cord-001734-bbeznd3r	233	66	like	like	JJ
cord-001734-bbeznd3r	233	67	protease	protease	NN
cord-001734-bbeznd3r	233	68	[	[	-LRB-
cord-001734-bbeznd3r	233	69	20	20	CD
cord-001734-bbeznd3r	233	70	,	,	,
cord-001734-bbeznd3r	233	71	21	21	CD
cord-001734-bbeznd3r	233	72	]	]	-RRB-
cord-001734-bbeznd3r	233	73	.	.	.
cord-001734-bbeznd3r	234	1	Therefore	therefore	RB
cord-001734-bbeznd3r	234	2	,	,	,
cord-001734-bbeznd3r	234	3	to	to	TO
cord-001734-bbeznd3r	234	4	understand	understand	VB
cord-001734-bbeznd3r	234	5	the	the	DT
cord-001734-bbeznd3r	234	6	role	role	NN
cord-001734-bbeznd3r	234	7	of	of	IN
cord-001734-bbeznd3r	234	8	the	the	DT
cord-001734-bbeznd3r	234	9	cofactor	cofactor	NN
cord-001734-bbeznd3r	234	10	in	in	IN
cord-001734-bbeznd3r	234	11	the	the	DT
cord-001734-bbeznd3r	234	12	dynamics	dynamic	NNS
cord-001734-bbeznd3r	234	13	of	of	IN
cord-001734-bbeznd3r	234	14	the	the	DT
cord-001734-bbeznd3r	234	15	dengue	dengue	NN
cord-001734-bbeznd3r	234	16	NS3	ns3	RB
cord-001734-bbeznd3r	234	17	protease	protease	NN
cord-001734-bbeznd3r	234	18	,	,	,
cord-001734-bbeznd3r	234	19	we	-PRON-	PRP
cord-001734-bbeznd3r	234	20	conducted	conduct	VBD
cord-001734-bbeznd3r	234	21	20-ns	20-ns	CD
cord-001734-bbeznd3r	234	22	MD	MD	NNP
cord-001734-bbeznd3r	234	23	simulations	simulation	NNS
cord-001734-bbeznd3r	234	24	for	for	IN
cord-001734-bbeznd3r	234	25	both	both	DT
cord-001734-bbeznd3r	234	26	NS2B	NS2B	NNP
cord-001734-bbeznd3r	234	27	-	-	HYPH
cord-001734-bbeznd3r	234	28	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	234	29	complex	complex	JJ
cord-001734-bbeznd3r	234	30	and	and	CC
cord-001734-bbeznd3r	234	31	isolated	isolated	JJ
cord-001734-bbeznd3r	234	32	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	234	33	respectively	respectively	RB
cord-001734-bbeznd3r	234	34	.	.	.
cord-001734-bbeznd3r	235	1	Here	here	RB
cord-001734-bbeznd3r	235	2	we	-PRON-	PRP
cord-001734-bbeznd3r	235	3	used	use	VBD
cord-001734-bbeznd3r	235	4	the	the	DT
cord-001734-bbeznd3r	235	5	crystal	crystal	NN
cord-001734-bbeznd3r	235	6	structure	structure	NN
cord-001734-bbeznd3r	235	7	of	of	IN
cord-001734-bbeznd3r	235	8	the	the	DT
cord-001734-bbeznd3r	235	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	235	10	-	-	HYPH
cord-001734-bbeznd3r	235	11	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	235	12	complex	complex	NN
cord-001734-bbeznd3r	235	13	(	(	-LRB-
cord-001734-bbeznd3r	235	14	PDB	PDB	NNP
cord-001734-bbeznd3r	235	15	code	code	NN
cord-001734-bbeznd3r	235	16	:	:	:
cord-001734-bbeznd3r	235	17	2FOM	2fom	LS
cord-001734-bbeznd3r	235	18	)	)	-RRB-
cord-001734-bbeznd3r	235	19	with	with	IN
cord-001734-bbeznd3r	235	20	an	an	DT
cord-001734-bbeznd3r	235	21	open	open	JJ
cord-001734-bbeznd3r	235	22	conformation	conformation	NN
cord-001734-bbeznd3r	235	23	[	[	-LRB-
cord-001734-bbeznd3r	235	24	7	7	CD
cord-001734-bbeznd3r	235	25	]	]	-RRB-
cord-001734-bbeznd3r	235	26	for	for	IN
cord-001734-bbeznd3r	235	27	MD	MD	NNP
cord-001734-bbeznd3r	235	28	simulations	simulation	NNS
cord-001734-bbeznd3r	235	29	,	,	,
cord-001734-bbeznd3r	235	30	because	because	IN
cord-001734-bbeznd3r	235	31	this	this	DT
cord-001734-bbeznd3r	235	32	complex	complex	NN
cord-001734-bbeznd3r	235	33	has	have	VBZ
cord-001734-bbeznd3r	235	34	sequences	sequence	NNS
cord-001734-bbeznd3r	235	35	almost	almost	RB
cord-001734-bbeznd3r	235	36	identical	identical	JJ
cord-001734-bbeznd3r	235	37	to	to	IN
cord-001734-bbeznd3r	235	38	what	what	WP
cord-001734-bbeznd3r	235	39	we	-PRON-	PRP
cord-001734-bbeznd3r	235	40	studied	study	VBD
cord-001734-bbeznd3r	235	41	here	here	RB
cord-001734-bbeznd3r	235	42	,	,	,
cord-001734-bbeznd3r	235	43	with	with	IN
cord-001734-bbeznd3r	235	44	only	only	RB
cord-001734-bbeznd3r	235	45	one	one	CD
cord-001734-bbeznd3r	235	46	and	and	CC
cord-001734-bbeznd3r	235	47	two	two	CD
cord-001734-bbeznd3r	235	48	conserved	conserved	JJ
cord-001734-bbeznd3r	235	49	residue	residue	NN
cord-001734-bbeznd3r	235	50	variations	variation	NNS
cord-001734-bbeznd3r	235	51	respectively	respectively	RB
cord-001734-bbeznd3r	235	52	as	as	IN
cord-001734-bbeznd3r	235	53	compared	compare	VBN
cord-001734-bbeznd3r	235	54	to	to	IN
cord-001734-bbeznd3r	235	55	our	-PRON-	PRP$
cord-001734-bbeznd3r	235	56	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	235	57	and	and	CC
cord-001734-bbeznd3r	235	58	NS2B	NS2B	NNP
cord-001734-bbeznd3r	235	59	constructs	construct	NNS
cord-001734-bbeznd3r	235	60	.	.	.
cord-001734-bbeznd3r	236	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	236	2	,	,	,
cord-001734-bbeznd3r	236	3	in	in	IN
cord-001734-bbeznd3r	236	4	this	this	DT
cord-001734-bbeznd3r	236	5	structure	structure	NN
cord-001734-bbeznd3r	236	6	,	,	,
cord-001734-bbeznd3r	236	7	the	the	DT
cord-001734-bbeznd3r	236	8	NS2B	NS2B	NNP
cord-001734-bbeznd3r	236	9	cofactor	cofactor	NN
cord-001734-bbeznd3r	236	10	assumes	assume	VBZ
cord-001734-bbeznd3r	236	11	an	an	DT
cord-001734-bbeznd3r	236	12	open	open	JJ
cord-001734-bbeznd3r	236	13	conformation	conformation	NN
cord-001734-bbeznd3r	236	14	,	,	,
cord-001734-bbeznd3r	236	15	thus	thus	RB
cord-001734-bbeznd3r	236	16	has	have	VBZ
cord-001734-bbeznd3r	236	17	a	a	DT
cord-001734-bbeznd3r	236	18	minimal	minimal	JJ
cord-001734-bbeznd3r	236	19	contact	contact	NN
cord-001734-bbeznd3r	236	20	surface	surface	NN
cord-001734-bbeznd3r	236	21	with	with	IN
cord-001734-bbeznd3r	236	22	the	the	DT
cord-001734-bbeznd3r	236	23	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	236	24	domain	domain	NN
cord-001734-bbeznd3r	236	25	as	as	IN
cord-001734-bbeznd3r	236	26	compared	compare	VBN
cord-001734-bbeznd3r	236	27	to	to	IN
cord-001734-bbeznd3r	236	28	other	other	JJ
cord-001734-bbeznd3r	236	29	structures	structure	NNS
cord-001734-bbeznd3r	236	30	with	with	IN
cord-001734-bbeznd3r	236	31	the	the	DT
cord-001734-bbeznd3r	236	32	closed	closed	JJ
cord-001734-bbeznd3r	236	33	conformation	conformation	NN
cord-001734-bbeznd3r	236	34	.	.	.
cord-001734-bbeznd3r	237	1	This	this	DT
cord-001734-bbeznd3r	237	2	would	would	MD
cord-001734-bbeznd3r	237	3	facilitate	facilitate	VB
cord-001734-bbeznd3r	237	4	the	the	DT
cord-001734-bbeznd3r	237	5	identification	identification	NN
cord-001734-bbeznd3r	237	6	of	of	IN
cord-001734-bbeznd3r	237	7	the	the	DT
cord-001734-bbeznd3r	237	8	most	most	RBS
cord-001734-bbeznd3r	237	9	important	important	JJ
cord-001734-bbeznd3r	237	10	residues	residue	NNS
cord-001734-bbeznd3r	237	11	of	of	IN
cord-001734-bbeznd3r	237	12	the	the	DT
cord-001734-bbeznd3r	237	13	NS2B	NS2B	NNP
cord-001734-bbeznd3r	237	14	in	in	IN
cord-001734-bbeznd3r	237	15	mediating	mediate	VBG
cord-001734-bbeznd3r	237	16	the	the	DT
cord-001734-bbeznd3r	237	17	dynamics	dynamic	NNS
cord-001734-bbeznd3r	237	18	of	of	IN
cord-001734-bbeznd3r	237	19	the	the	DT
cord-001734-bbeznd3r	237	20	protease	protease	NN
cord-001734-bbeznd3r	237	21	complex	complex	NN
cord-001734-bbeznd3r	237	22	.	.	.
cord-001734-bbeznd3r	238	1	Fig	fig	NN
cord-001734-bbeznd3r	238	2	5A	5a	NN
cord-001734-bbeznd3r	238	3	and	and	CC
cord-001734-bbeznd3r	238	4	5B	5b	NN
cord-001734-bbeznd3r	238	5	present	present	VBP
cord-001734-bbeznd3r	238	6	the	the	DT
cord-001734-bbeznd3r	238	7	structure	structure	NN
cord-001734-bbeznd3r	238	8	snapshots	snapshot	NNS
cord-001734-bbeznd3r	238	9	in	in	IN
cord-001734-bbeznd3r	238	10	the	the	DT
cord-001734-bbeznd3r	238	11	first	first	JJ
cord-001734-bbeznd3r	238	12	MD	MD	NNP
cord-001734-bbeznd3r	238	13	simulations	simulation	NNS
cord-001734-bbeznd3r	238	14	for	for	IN
cord-001734-bbeznd3r	238	15	the	the	DT
cord-001734-bbeznd3r	238	16	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	238	17	alone	alone	JJ
cord-001734-bbeznd3r	238	18	and	and	CC
cord-001734-bbeznd3r	238	19	the	the	DT
cord-001734-bbeznd3r	238	20	NS2B	NS2B	NNP
cord-001734-bbeznd3r	238	21	-	-	HYPH
cord-001734-bbeznd3r	238	22	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	238	23	complex	complex	NN
cord-001734-bbeznd3r	238	24	,	,	,
cord-001734-bbeznd3r	238	25	showing	show	VBG
cord-001734-bbeznd3r	238	26	that	that	IN
cord-001734-bbeznd3r	238	27	within	within	IN
cord-001734-bbeznd3r	238	28	20	20	CD
cord-001734-bbeznd3r	238	29	ns	n	NNS
cord-001734-bbeznd3r	238	30	,	,	,
cord-001734-bbeznd3r	238	31	both	both	DT
cord-001734-bbeznd3r	238	32	isolated	isolated	JJ
cord-001734-bbeznd3r	238	33	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	238	34	domain	domain	NN
cord-001734-bbeznd3r	238	35	and	and	CC
cord-001734-bbeznd3r	238	36	that	that	IN
cord-001734-bbeznd3r	238	37	in	in	IN
cord-001734-bbeznd3r	238	38	the	the	DT
cord-001734-bbeznd3r	238	39	complex	complex	NN
cord-001734-bbeznd3r	238	40	remains	remain	VBZ
cord-001734-bbeznd3r	238	41	dynamically	dynamically	RB
cord-001734-bbeznd3r	238	42	stable	stable	JJ
cord-001734-bbeznd3r	238	43	,	,	,
cord-001734-bbeznd3r	238	44	in	in	IN
cord-001734-bbeznd3r	238	45	particular	particular	JJ
cord-001734-bbeznd3r	238	46	over	over	IN
cord-001734-bbeznd3r	238	47	the	the	DT
cord-001734-bbeznd3r	238	48	regions	region	NNS
cord-001734-bbeznd3r	238	49	with	with	IN
cord-001734-bbeznd3r	238	50	regular	regular	JJ
cord-001734-bbeznd3r	238	51	secondary	secondary	JJ
cord-001734-bbeznd3r	238	52	structures	structure	NNS
cord-001734-bbeznd3r	238	53	.	.	.
cord-001734-bbeznd3r	239	1	By	by	IN
cord-001734-bbeznd3r	239	2	contrast	contrast	NN
cord-001734-bbeznd3r	239	3	,	,	,
cord-001734-bbeznd3r	239	4	the	the	DT
cord-001734-bbeznd3r	239	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	239	6	cofactor	cofactor	NN
cord-001734-bbeznd3r	239	7	has	have	VBZ
cord-001734-bbeznd3r	239	8	large	large	JJ
cord-001734-bbeznd3r	239	9	structural	structural	JJ
cord-001734-bbeznd3r	239	10	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	239	11	,	,	,
cord-001734-bbeznd3r	239	12	particularly	particularly	RB
cord-001734-bbeznd3r	239	13	over	over	IN
cord-001734-bbeznd3r	239	14	the	the	DT
cord-001734-bbeznd3r	239	15	residues	residue	NNS
cord-001734-bbeznd3r	239	16	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	239	17	which	which	WDT
cord-001734-bbeznd3r	239	18	are	be	VBP
cord-001734-bbeznd3r	239	19	invisible	invisible	JJ
cord-001734-bbeznd3r	239	20	in	in	IN
cord-001734-bbeznd3r	239	21	all	all	DT
cord-001734-bbeznd3r	239	22	previous	previous	JJ
cord-001734-bbeznd3r	239	23	crystal	crystal	NN
cord-001734-bbeznd3r	239	24	structures	structure	NNS
cord-001734-bbeznd3r	239	25	with	with	IN
cord-001734-bbeznd3r	239	26	an	an	DT
cord-001734-bbeznd3r	239	27	open	open	JJ
cord-001734-bbeznd3r	239	28	conformation	conformation	NN
cord-001734-bbeznd3r	239	29	.	.	.
cord-001734-bbeznd3r	240	1	Fig	Fig	NNP
cord-001734-bbeznd3r	240	2	5C-5E	5c-5e	CD
cord-001734-bbeznd3r	240	3	show	show	VBP
cord-001734-bbeznd3r	240	4	the	the	DT
cord-001734-bbeznd3r	240	5	root	root	NN
cord-001734-bbeznd3r	240	6	-	-	HYPH
cord-001734-bbeznd3r	240	7	mean	mean	JJ
cord-001734-bbeznd3r	240	8	-	-	HYPH
cord-001734-bbeznd3r	240	9	square	square	JJ
cord-001734-bbeznd3r	240	10	deviations	deviation	NNS
cord-001734-bbeznd3r	240	11	(	(	-LRB-
cord-001734-bbeznd3r	240	12	RMSD	RMSD	NNP
cord-001734-bbeznd3r	240	13	)	)	-RRB-
cord-001734-bbeznd3r	240	14	of	of	IN
cord-001734-bbeznd3r	240	15	Cα	Cα	NNP
cord-001734-bbeznd3r	240	16	atoms	atom	NNS
cord-001734-bbeznd3r	240	17	(	(	-LRB-
cord-001734-bbeznd3r	240	18	from	from	IN
cord-001734-bbeznd3r	240	19	their	-PRON-	PRP$
cord-001734-bbeznd3r	240	20	positions	position	NNS
cord-001734-bbeznd3r	240	21	in	in	IN
cord-001734-bbeznd3r	240	22	the	the	DT
cord-001734-bbeznd3r	240	23	energy	energy	NN
cord-001734-bbeznd3r	240	24	minimized	minimize	VBD
cord-001734-bbeznd3r	240	25	structures	structure	NNS
cord-001734-bbeznd3r	240	26	)	)	-RRB-
cord-001734-bbeznd3r	240	27	for	for	IN
cord-001734-bbeznd3r	240	28	three	three	CD
cord-001734-bbeznd3r	240	29	independent	independent	JJ
cord-001734-bbeznd3r	240	30	simulations	simulation	NNS
cord-001734-bbeznd3r	240	31	of	of	IN
cord-001734-bbeznd3r	240	32	the	the	DT
cord-001734-bbeznd3r	240	33	isolated	isolated	JJ
cord-001734-bbeznd3r	240	34	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	240	35	,	,	,
cord-001734-bbeznd3r	240	36	the	the	DT
cord-001734-bbeznd3r	240	37	NS2B	NS2B	NNP
cord-001734-bbeznd3r	240	38	and	and	CC
cord-001734-bbeznd3r	240	39	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	240	40	in	in	IN
cord-001734-bbeznd3r	240	41	the	the	DT
cord-001734-bbeznd3r	240	42	context	context	NN
cord-001734-bbeznd3r	240	43	of	of	IN
cord-001734-bbeznd3r	240	44	the	the	DT
cord-001734-bbeznd3r	240	45	complex	complex	JJ
cord-001734-bbeznd3r	240	46	respectively	respectively	RB
cord-001734-bbeznd3r	240	47	,	,	,
cord-001734-bbeznd3r	240	48	and	and	CC
cord-001734-bbeznd3r	240	49	Fig	Fig	NNP
cord-001734-bbeznd3r	240	50	  	  	_SP
cord-001734-bbeznd3r	240	51	Fig	Fig	NNP
cord-001734-bbeznd3r	240	52	5	5	CD
cord-001734-bbeznd3r	240	53	.	.	.
cord-001734-bbeznd3r	241	1	Overall	overall	JJ
cord-001734-bbeznd3r	241	2	dynamic	dynamic	JJ
cord-001734-bbeznd3r	241	3	behaviors	behavior	NNS
cord-001734-bbeznd3r	241	4	in	in	IN
cord-001734-bbeznd3r	241	5	the	the	DT
cord-001734-bbeznd3r	241	6	MD	MD	NNP
cord-001734-bbeznd3r	241	7	simulations	simulation	NNS
cord-001734-bbeznd3r	241	8	.	.	.
cord-001734-bbeznd3r	242	1	Structure	structure	NN
cord-001734-bbeznd3r	242	2	snapshots	snapshot	NNS
cord-001734-bbeznd3r	242	3	(	(	-LRB-
cord-001734-bbeznd3r	242	4	one	one	CD
cord-001734-bbeznd3r	242	5	structure	structure	NN
cord-001734-bbeznd3r	242	6	for	for	IN
cord-001734-bbeznd3r	242	7	2-ns	2-ns	CD
cord-001734-bbeznd3r	242	8	interval	interval	NN
cord-001734-bbeznd3r	242	9	)	)	-RRB-
cord-001734-bbeznd3r	242	10	of	of	IN
cord-001734-bbeznd3r	242	11	the	the	DT
cord-001734-bbeznd3r	242	12	first	first	JJ
cord-001734-bbeznd3r	242	13	MD	MD	NNP
cord-001734-bbeznd3r	242	14	simulations	simulation	NNS
cord-001734-bbeznd3r	242	15	respectively	respectively	RB
cord-001734-bbeznd3r	242	16	for	for	IN
cord-001734-bbeznd3r	242	17	the	the	DT
cord-001734-bbeznd3r	242	18	isolated	isolated	JJ
cord-001734-bbeznd3r	242	19	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	242	20	(	(	-LRB-
cord-001734-bbeznd3r	242	21	A	a	NN
cord-001734-bbeznd3r	242	22	)	)	-RRB-
cord-001734-bbeznd3r	242	23	and	and	CC
cord-001734-bbeznd3r	242	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	242	25	-	-	HYPH
cord-001734-bbeznd3r	242	26	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	242	27	complex	complex	NN
cord-001734-bbeznd3r	242	28	(	(	-LRB-
cord-001734-bbeznd3r	242	29	B	b	NN
cord-001734-bbeznd3r	242	30	)	)	-RRB-
cord-001734-bbeznd3r	242	31	.	.	.
cord-001734-bbeznd3r	243	1	Root	root	NN
cord-001734-bbeznd3r	243	2	-	-	HYPH
cord-001734-bbeznd3r	243	3	mean	mean	JJ
cord-001734-bbeznd3r	243	4	-	-	HYPH
cord-001734-bbeznd3r	243	5	square	square	JJ
cord-001734-bbeznd3r	243	6	deviations	deviation	NNS
cord-001734-bbeznd3r	243	7	(	(	-LRB-
cord-001734-bbeznd3r	243	8	RMSD	RMSD	NNP
cord-001734-bbeznd3r	243	9	)	)	-RRB-
cord-001734-bbeznd3r	243	10	of	of	IN
cord-001734-bbeznd3r	243	11	the	the	DT
cord-001734-bbeznd3r	243	12	Cα	Cα	NNP
cord-001734-bbeznd3r	243	13	atoms	atom	NNS
cord-001734-bbeznd3r	243	14	(	(	-LRB-
cord-001734-bbeznd3r	243	15	from	from	IN
cord-001734-bbeznd3r	243	16	their	-PRON-	PRP$
cord-001734-bbeznd3r	243	17	positions	position	NNS
cord-001734-bbeznd3r	243	18	in	in	IN
cord-001734-bbeznd3r	243	19	the	the	DT
cord-001734-bbeznd3r	243	20	energy	energy	NN
cord-001734-bbeznd3r	243	21	minimized	minimize	VBD
cord-001734-bbeznd3r	243	22	structures	structure	NNS
cord-001734-bbeznd3r	243	23	)	)	-RRB-
cord-001734-bbeznd3r	243	24	for	for	IN
cord-001734-bbeznd3r	243	25	three	three	CD
cord-001734-bbeznd3r	243	26	independent	independent	JJ
cord-001734-bbeznd3r	243	27	MD	MD	NNP
cord-001734-bbeznd3r	243	28	simulations	simulation	NNS
cord-001734-bbeznd3r	243	29	of	of	IN
cord-001734-bbeznd3r	243	30	the	the	DT
cord-001734-bbeznd3r	243	31	isolated	isolated	JJ
cord-001734-bbeznd3r	243	32	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	243	33	(	(	-LRB-
cord-001734-bbeznd3r	243	34	C	C	NNP
cord-001734-bbeznd3r	243	35	)	)	-RRB-
cord-001734-bbeznd3r	243	36	,	,	,
cord-001734-bbeznd3r	243	37	the	the	DT
cord-001734-bbeznd3r	243	38	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	243	39	(	(	-LRB-
cord-001734-bbeznd3r	243	40	D	D	NNP
cord-001734-bbeznd3r	243	41	)	)	-RRB-
cord-001734-bbeznd3r	243	42	and	and	CC
cord-001734-bbeznd3r	243	43	NS2B	NS2B	NNP
cord-001734-bbeznd3r	243	44	(	(	-LRB-
cord-001734-bbeznd3r	243	45	E	E	NNP
cord-001734-bbeznd3r	243	46	)	)	-RRB-
cord-001734-bbeznd3r	243	47	in	in	IN
cord-001734-bbeznd3r	243	48	the	the	DT
cord-001734-bbeznd3r	243	49	context	context	NN
cord-001734-bbeznd3r	243	50	of	of	IN
cord-001734-bbeznd3r	243	51	the	the	DT
cord-001734-bbeznd3r	243	52	NS2B	NS2B	NNP
cord-001734-bbeznd3r	243	53	-	-	HYPH
cord-001734-bbeznd3r	243	54	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	243	55	complex	complex	NN
cord-001734-bbeznd3r	243	56	.	.	.
cord-001734-bbeznd3r	244	1	(	(	-LRB-
cord-001734-bbeznd3r	244	2	F	F	NNP
cord-001734-bbeznd3r	244	3	)	)	-RRB-
cord-001734-bbeznd3r	244	4	RMSD	RMSD	NNP
cord-001734-bbeznd3r	244	5	trajectories	trajectory	NNS
cord-001734-bbeznd3r	244	6	averaged	average	VBD
cord-001734-bbeznd3r	244	7	over	over	IN
cord-001734-bbeznd3r	244	8	three	three	CD
cord-001734-bbeznd3r	244	9	independent	independent	JJ
cord-001734-bbeznd3r	244	10	MD	MD	NNP
cord-001734-bbeznd3r	244	11	simulations	simulation	NNS
cord-001734-bbeznd3r	244	12	of	of	IN
cord-001734-bbeznd3r	244	13	the	the	DT
cord-001734-bbeznd3r	244	14	isolated	isolated	JJ
cord-001734-bbeznd3r	244	15	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	244	16	(	(	-LRB-
cord-001734-bbeznd3r	244	17	blue	blue	NNP
cord-001734-bbeznd3r	244	18	)	)	-RRB-
cord-001734-bbeznd3r	244	19	,	,	,
cord-001734-bbeznd3r	244	20	the	the	DT
cord-001734-bbeznd3r	244	21	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	244	22	(	(	-LRB-
cord-001734-bbeznd3r	244	23	red	red	JJ
cord-001734-bbeznd3r	244	24	)	)	-RRB-
cord-001734-bbeznd3r	244	25	and	and	CC
cord-001734-bbeznd3r	244	26	NS2B	NS2B	NNP
cord-001734-bbeznd3r	244	27	(	(	-LRB-
cord-001734-bbeznd3r	244	28	cyan	cyan	NNP
cord-001734-bbeznd3r	244	29	)	)	-RRB-
cord-001734-bbeznd3r	244	30	in	in	IN
cord-001734-bbeznd3r	244	31	the	the	DT
cord-001734-bbeznd3r	244	32	context	context	NN
cord-001734-bbeznd3r	244	33	of	of	IN
cord-001734-bbeznd3r	244	34	the	the	DT
cord-001734-bbeznd3r	244	35	NS2B	NS2B	NNP
cord-001734-bbeznd3r	244	36	-	-	HYPH
cord-001734-bbeznd3r	244	37	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	244	38	complex	complex	NN
cord-001734-bbeznd3r	244	39	.	.	.
cord-001734-bbeznd3r	245	1	5F	5F	NNP
cord-001734-bbeznd3r	245	2	shows	show	VBZ
cord-001734-bbeznd3r	245	3	their	-PRON-	PRP$
cord-001734-bbeznd3r	245	4	averaged	average	VBN
cord-001734-bbeznd3r	245	5	RMSD	RMSD	NNP
cord-001734-bbeznd3r	245	6	trajectories	trajectory	NNS
cord-001734-bbeznd3r	245	7	.	.	.
cord-001734-bbeznd3r	246	1	The	the	DT
cord-001734-bbeznd3r	246	2	averaged	average	VBN
cord-001734-bbeznd3r	246	3	RMSD	RMSD	NNP
cord-001734-bbeznd3r	246	4	values	value	NNS
cord-001734-bbeznd3r	246	5	are	be	VBP
cord-001734-bbeznd3r	246	6	1.85	1.85	CD
cord-001734-bbeznd3r	246	7	±	±	CD
cord-001734-bbeznd3r	246	8	0.23	0.23	CD
cord-001734-bbeznd3r	246	9	,	,	,
cord-001734-bbeznd3r	246	10	1.56	1.56	CD
cord-001734-bbeznd3r	246	11	±	±	CD
cord-001734-bbeznd3r	246	12	0.22	0.22	CD
cord-001734-bbeznd3r	246	13	and	and	CC
cord-001734-bbeznd3r	246	14	4.40	4.40	CD
cord-001734-bbeznd3r	246	15	±	±	CD
cord-001734-bbeznd3r	246	16	0.71	0.71	CD
cord-001734-bbeznd3r	246	17	Å	Å	NNP
cord-001734-bbeznd3r	246	18	respectively	respectively	RB
cord-001734-bbeznd3r	246	19	for	for	IN
cord-001734-bbeznd3r	246	20	the	the	DT
cord-001734-bbeznd3r	246	21	isolated	isolated	JJ
cord-001734-bbeznd3r	246	22	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	246	23	,	,	,
cord-001734-bbeznd3r	246	24	the	the	DT
cord-001734-bbeznd3r	246	25	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	246	26	and	and	CC
cord-001734-bbeznd3r	246	27	NS2B	NS2B	NNP
cord-001734-bbeznd3r	246	28	in	in	IN
cord-001734-bbeznd3r	246	29	the	the	DT
cord-001734-bbeznd3r	246	30	context	context	NN
cord-001734-bbeznd3r	246	31	of	of	IN
cord-001734-bbeznd3r	246	32	the	the	DT
cord-001734-bbeznd3r	246	33	complex	complex	NN
cord-001734-bbeznd3r	246	34	.	.	.
cord-001734-bbeznd3r	247	1	This	this	DT
cord-001734-bbeznd3r	247	2	clearly	clearly	RB
cord-001734-bbeznd3r	247	3	indicates	indicate	VBZ
cord-001734-bbeznd3r	247	4	that	that	IN
cord-001734-bbeznd3r	247	5	upon	upon	IN
cord-001734-bbeznd3r	247	6	removing	remove	VBG
cord-001734-bbeznd3r	247	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	247	8	,	,	,
cord-001734-bbeznd3r	247	9	the	the	DT
cord-001734-bbeznd3r	247	10	isolated	isolated	JJ
cord-001734-bbeznd3r	247	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	247	12	domain	domain	NN
cord-001734-bbeznd3r	247	13	will	will	MD
cord-001734-bbeznd3r	247	14	have	have	VB
cord-001734-bbeznd3r	247	15	higher	high	JJR
cord-001734-bbeznd3r	247	16	conformational	conformational	JJ
cord-001734-bbeznd3r	247	17	dynamics	dynamic	NNS
cord-001734-bbeznd3r	247	18	even	even	RB
cord-001734-bbeznd3r	247	19	within	within	IN
cord-001734-bbeznd3r	247	20	the	the	DT
cord-001734-bbeznd3r	247	21	20-ns	20-ns	CD
cord-001734-bbeznd3r	247	22	simulations	simulation	NNS
cord-001734-bbeznd3r	247	23	.	.	.
cord-001734-bbeznd3r	248	1	As	as	IN
cord-001734-bbeznd3r	248	2	such	such	JJ
cord-001734-bbeznd3r	248	3	,	,	,
cord-001734-bbeznd3r	248	4	it	-PRON-	PRP
cord-001734-bbeznd3r	248	5	is	be	VBZ
cord-001734-bbeznd3r	248	6	expected	expect	VBN
cord-001734-bbeznd3r	248	7	that	that	IN
cord-001734-bbeznd3r	248	8	the	the	DT
cord-001734-bbeznd3r	248	9	isolated	isolated	JJ
cord-001734-bbeznd3r	248	10	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	248	11	domain	domain	NN
cord-001734-bbeznd3r	248	12	may	may	MD
cord-001734-bbeznd3r	248	13	become	become	VB
cord-001734-bbeznd3r	248	14	unfolded	unfolded	JJ
cord-001734-bbeznd3r	248	15	if	if	IN
cord-001734-bbeznd3r	248	16	the	the	DT
cord-001734-bbeznd3r	248	17	simulations	simulation	NNS
cord-001734-bbeznd3r	248	18	could	could	MD
cord-001734-bbeznd3r	248	19	reach	reach	VB
cord-001734-bbeznd3r	248	20	ms	ms	NNP
cord-001734-bbeznd3r	248	21	-	-	HYPH
cord-001734-bbeznd3r	248	22	s	s	NNP
cord-001734-bbeznd3r	248	23	time	time	NN
cord-001734-bbeznd3r	248	24	scale	scale	NN
cord-001734-bbeznd3r	248	25	.	.	.
cord-001734-bbeznd3r	249	1	On	on	IN
cord-001734-bbeznd3r	249	2	the	the	DT
cord-001734-bbeznd3r	249	3	other	other	JJ
cord-001734-bbeznd3r	249	4	hand	hand	NN
cord-001734-bbeznd3r	249	5	,	,	,
cord-001734-bbeznd3r	249	6	even	even	RB
cord-001734-bbeznd3r	249	7	in	in	IN
cord-001734-bbeznd3r	249	8	the	the	DT
cord-001734-bbeznd3r	249	9	context	context	NN
cord-001734-bbeznd3r	249	10	of	of	IN
cord-001734-bbeznd3r	249	11	the	the	DT
cord-001734-bbeznd3r	249	12	complex	complex	NN
cord-001734-bbeznd3r	249	13	,	,	,
cord-001734-bbeznd3r	249	14	the	the	DT
cord-001734-bbeznd3r	249	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	249	16	cofactor	cofactor	NN
cord-001734-bbeznd3r	249	17	has	have	VBZ
cord-001734-bbeznd3r	249	18	much	much	RB
cord-001734-bbeznd3r	249	19	higher	high	JJR
cord-001734-bbeznd3r	249	20	structural	structural	JJ
cord-001734-bbeznd3r	249	21	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	249	22	than	than	IN
cord-001734-bbeznd3r	249	23	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	249	24	,	,	,
cord-001734-bbeznd3r	249	25	implying	imply	VBG
cord-001734-bbeznd3r	249	26	that	that	IN
cord-001734-bbeznd3r	249	27	the	the	DT
cord-001734-bbeznd3r	249	28	bound	bind	VBN
cord-001734-bbeznd3r	249	29	NS2B	NS2B	NNP
cord-001734-bbeznd3r	249	30	cofactor	cofactor	NN
cord-001734-bbeznd3r	249	31	is	be	VBZ
cord-001734-bbeznd3r	249	32	still	still	RB
cord-001734-bbeznd3r	249	33	capable	capable	JJ
cord-001734-bbeznd3r	249	34	to	to	TO
cord-001734-bbeznd3r	249	35	sample	sample	VB
cord-001734-bbeznd3r	249	36	a	a	DT
cord-001734-bbeznd3r	249	37	large	large	JJ
cord-001734-bbeznd3r	249	38	ensemble	ensemble	NN
cord-001734-bbeznd3r	249	39	of	of	IN
cord-001734-bbeznd3r	249	40	conformations	conformation	NNS
cord-001734-bbeznd3r	249	41	.	.	.
cord-001734-bbeznd3r	250	1	The	the	DT
cord-001734-bbeznd3r	250	2	high	high	JJ
cord-001734-bbeznd3r	250	3	flexibility	flexibility	NN
cord-001734-bbeznd3r	250	4	of	of	IN
cord-001734-bbeznd3r	250	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	250	6	uncovered	uncover	VBN
cord-001734-bbeznd3r	250	7	by	by	IN
cord-001734-bbeznd3r	250	8	MD	MD	NNP
cord-001734-bbeznd3r	250	9	simulations	simulation	NNS
cord-001734-bbeznd3r	250	10	here	here	RB
cord-001734-bbeznd3r	250	11	is	be	VBZ
cord-001734-bbeznd3r	250	12	completely	completely	RB
cord-001734-bbeznd3r	250	13	consistent	consistent	JJ
cord-001734-bbeznd3r	250	14	with	with	IN
cord-001734-bbeznd3r	250	15	the	the	DT
cord-001734-bbeznd3r	250	16	invisibility	invisibility	NN
cord-001734-bbeznd3r	250	17	of	of	IN
cord-001734-bbeznd3r	250	18	many	many	JJ
cord-001734-bbeznd3r	250	19	cofactor	cofactor	NN
cord-001734-bbeznd3r	250	20	residues	residue	NNS
cord-001734-bbeznd3r	250	21	in	in	IN
cord-001734-bbeznd3r	250	22	crystal	crystal	NN
cord-001734-bbeznd3r	250	23	structures	structure	NNS
cord-001734-bbeznd3r	250	24	and	and	CC
cord-001734-bbeznd3r	250	25	also	also	RB
cord-001734-bbeznd3r	250	26	provides	provide	VBZ
cord-001734-bbeznd3r	250	27	a	a	DT
cord-001734-bbeznd3r	250	28	dynamic	dynamic	JJ
cord-001734-bbeznd3r	250	29	basis	basis	NN
cord-001734-bbeznd3r	250	30	for	for	IN
cord-001734-bbeznd3r	250	31	the	the	DT
cord-001734-bbeznd3r	250	32	conformational	conformational	JJ
cord-001734-bbeznd3r	250	33	exchange	exchange	NN
cord-001734-bbeznd3r	250	34	of	of	IN
cord-001734-bbeznd3r	250	35	NS2B	NS2B	NNP
cord-001734-bbeznd3r	250	36	between	between	IN
cord-001734-bbeznd3r	250	37	open	open	JJ
cord-001734-bbeznd3r	250	38	and	and	CC
cord-001734-bbeznd3r	250	39	closed	closed	JJ
cord-001734-bbeznd3r	250	40	conformations	conformation	NNS
cord-001734-bbeznd3r	250	41	as	as	IN
cord-001734-bbeznd3r	250	42	previously	previously	RB
cord-001734-bbeznd3r	250	43	observed	observe	VBD
cord-001734-bbeznd3r	250	44	[	[	-LRB-
cord-001734-bbeznd3r	250	45	8	8	CD
cord-001734-bbeznd3r	250	46	]	]	-RRB-
cord-001734-bbeznd3r	250	47	[	[	-LRB-
cord-001734-bbeznd3r	250	48	9	9	CD
cord-001734-bbeznd3r	250	49	]	]	-RRB-
cord-001734-bbeznd3r	250	50	[	[	-LRB-
cord-001734-bbeznd3r	250	51	10	10	CD
cord-001734-bbeznd3r	250	52	]	]	-RRB-
cord-001734-bbeznd3r	250	53	[	[	-LRB-
cord-001734-bbeznd3r	250	54	11	11	CD
cord-001734-bbeznd3r	250	55	]	]	-RRB-
cord-001734-bbeznd3r	250	56	[	[	-LRB-
cord-001734-bbeznd3r	250	57	12	12	CD
cord-001734-bbeznd3r	250	58	]	]	-RRB-
cord-001734-bbeznd3r	250	59	.	.	.
cord-001734-bbeznd3r	251	1	Noticeably	noticeably	RB
cord-001734-bbeznd3r	251	2	,	,	,
cord-001734-bbeznd3r	251	3	similar	similar	JJ
cord-001734-bbeznd3r	251	4	dynamic	dynamic	JJ
cord-001734-bbeznd3r	251	5	behaviours	behaviour	NNS
cord-001734-bbeznd3r	251	6	are	be	VBP
cord-001734-bbeznd3r	251	7	also	also	RB
cord-001734-bbeznd3r	251	8	reflected	reflect	VBN
cord-001734-bbeznd3r	251	9	by	by	IN
cord-001734-bbeznd3r	251	10	the	the	DT
cord-001734-bbeznd3r	251	11	root	root	NN
cord-001734-bbeznd3r	251	12	-	-	HYPH
cord-001734-bbeznd3r	251	13	mean	mean	JJ
cord-001734-bbeznd3r	251	14	-	-	HYPH
cord-001734-bbeznd3r	251	15	square	square	JJ
cord-001734-bbeznd3r	251	16	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	251	17	(	(	-LRB-
cord-001734-bbeznd3r	251	18	RMSF	RMSF	NNP
cord-001734-bbeznd3r	251	19	)	)	-RRB-
cord-001734-bbeznd3r	251	20	of	of	IN
cord-001734-bbeznd3r	251	21	the	the	DT
cord-001734-bbeznd3r	251	22	Cα	Cα	NNP
cord-001734-bbeznd3r	251	23	atoms	atom	NNS
cord-001734-bbeznd3r	251	24	in	in	IN
cord-001734-bbeznd3r	251	25	the	the	DT
cord-001734-bbeznd3r	251	26	MD	MD	NNP
cord-001734-bbeznd3r	251	27	simulations	simulation	NNS
cord-001734-bbeznd3r	251	28	(	(	-LRB-
cord-001734-bbeznd3r	251	29	Fig	Fig	NNP
cord-001734-bbeznd3r	251	30	6A	6a	CD
cord-001734-bbeznd3r	251	31	and	and	CC
cord-001734-bbeznd3r	251	32	6B	6b	CD
cord-001734-bbeznd3r	251	33	)	)	-RRB-
cord-001734-bbeznd3r	251	34	.	.	.
cord-001734-bbeznd3r	252	1	Fig	Fig	NNP
cord-001734-bbeznd3r	252	2	6C	6c	NN
cord-001734-bbeznd3r	252	3	presents	present	VBZ
cord-001734-bbeznd3r	252	4	the	the	DT
cord-001734-bbeznd3r	252	5	averaged	average	VBN
cord-001734-bbeznd3r	252	6	RMSF	RMSF	NNP
cord-001734-bbeznd3r	252	7	of	of	IN
cord-001734-bbeznd3r	252	8	three	three	CD
cord-001734-bbeznd3r	252	9	trajectories	trajectory	NNS
cord-001734-bbeznd3r	252	10	for	for	IN
cord-001734-bbeznd3r	252	11	the	the	DT
cord-001734-bbeznd3r	252	12	isolated	isolated	JJ
cord-001734-bbeznd3r	252	13	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	252	14	and	and	CC
cord-001734-bbeznd3r	252	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	252	16	-	-	HYPH
cord-001734-bbeznd3r	252	17	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	252	18	complex	complex	NN
cord-001734-bbeznd3r	252	19	.	.	.
cord-001734-bbeznd3r	253	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	253	2	,	,	,
cord-001734-bbeznd3r	253	3	only	only	RB
cord-001734-bbeznd3r	253	4	three	three	CD
cord-001734-bbeznd3r	253	5	regions	region	NNS
cord-001734-bbeznd3r	253	6	of	of	IN
cord-001734-bbeznd3r	253	7	the	the	DT
cord-001734-bbeznd3r	253	8	isolated	isolated	JJ
cord-001734-bbeznd3r	253	9	NS3pro	NS3pro	NNS
cord-001734-bbeznd3r	253	10	have	have	VBP
cord-001734-bbeznd3r	253	11	slightly	slightly	RB
cord-001734-bbeznd3r	253	12	higher	high	JJR
cord-001734-bbeznd3r	253	13	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	253	14	than	than	IN
cord-001734-bbeznd3r	253	15	the	the	DT
cord-001734-bbeznd3r	253	16	corresponding	correspond	VBG
cord-001734-bbeznd3r	253	17	ones	one	NNS
cord-001734-bbeznd3r	253	18	in	in	IN
cord-001734-bbeznd3r	253	19	the	the	DT
cord-001734-bbeznd3r	253	20	complex	complex	NN
cord-001734-bbeznd3r	253	21	.	.	.
cord-001734-bbeznd3r	254	1	The	the	DT
cord-001734-bbeznd3r	254	2	highest	high	JJS
cord-001734-bbeznd3r	254	3	structural	structural	JJ
cord-001734-bbeznd3r	254	4	fluctuations	fluctuation	NNS
cord-001734-bbeznd3r	254	5	are	be	VBP
cord-001734-bbeznd3r	254	6	observed	observe	VBN
cord-001734-bbeznd3r	254	7	on	on	IN
cord-001734-bbeznd3r	254	8	the	the	DT
cord-001734-bbeznd3r	254	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	254	10	residues	residue	NNS
cord-001734-bbeznd3r	254	11	.	.	.
cord-001734-bbeznd3r	255	1	More	more	RBR
cord-001734-bbeznd3r	255	2	specifically	specifically	RB
cord-001734-bbeznd3r	255	3	,	,	,
cord-001734-bbeznd3r	255	4	the	the	DT
cord-001734-bbeznd3r	255	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	255	6	residues	residue	NNS
cord-001734-bbeznd3r	255	7	with	with	IN
cord-001734-bbeznd3r	255	8	RMSF	RMSF	NNP
cord-001734-bbeznd3r	256	1	>	>	XX
cord-001734-bbeznd3r	257	1	the	the	DT
cord-001734-bbeznd3r	257	2	average	average	JJ
cord-001734-bbeznd3r	257	3	are	be	VBP
cord-001734-bbeznd3r	257	4	over	over	IN
cord-001734-bbeznd3r	257	5	N-/Cterminal	n-/cterminal	JJ
cord-001734-bbeznd3r	257	6	residues	residue	NNS
cord-001734-bbeznd3r	257	7	G43-Ala49	G43-Ala49	NNP
cord-001734-bbeznd3r	257	8	and	and	CC
cord-001734-bbeznd3r	257	9	Leu95-Gly96	Leu95-Gly96	NNP
cord-001734-bbeznd3r	257	10	,	,	,
cord-001734-bbeznd3r	257	11	as	as	RB
cord-001734-bbeznd3r	257	12	well	well	RB
cord-001734-bbeznd3r	257	13	as	as	IN
cord-001734-bbeznd3r	257	14	Ser75-Glu89	ser75-glu89	NN
cord-001734-bbeznd3r	257	15	which	which	WDT
cord-001734-bbeznd3r	257	16	include	include	VBP
cord-001734-bbeznd3r	257	17	the	the	DT
cord-001734-bbeznd3r	257	18	missing	miss	VBG
cord-001734-bbeznd3r	257	19	residues	residue	NNS
cord-001734-bbeznd3r	257	20	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	257	21	in	in	IN
cord-001734-bbeznd3r	257	22	all	all	DT
cord-001734-bbeznd3r	257	23	crystal	crystal	NN
cord-001734-bbeznd3r	257	24	structures	structure	NNS
cord-001734-bbeznd3r	257	25	of	of	IN
cord-001734-bbeznd3r	257	26	the	the	DT
cord-001734-bbeznd3r	257	27	open	open	JJ
cord-001734-bbeznd3r	257	28	form	form	NN
cord-001734-bbeznd3r	257	29	[	[	-LRB-
cord-001734-bbeznd3r	257	30	7	7	CD
cord-001734-bbeznd3r	257	31	]	]	-RRB-
cord-001734-bbeznd3r	257	32	.	.	.
cord-001734-bbeznd3r	258	1	Strikingly	strikingly	RB
cord-001734-bbeznd3r	258	2	,	,	,
cord-001734-bbeznd3r	258	3	the	the	DT
cord-001734-bbeznd3r	258	4	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	258	5	residues	residue	NNS
cord-001734-bbeznd3r	258	6	with	with	IN
cord-001734-bbeznd3r	258	7	RMSF	RMSF	NNP
cord-001734-bbeznd3r	258	8	>	>	XX
cord-001734-bbeznd3r	258	9	the	the	DT
cord-001734-bbeznd3r	258	10	average	average	NN
cord-001734-bbeznd3r	258	11	are	be	VBP
cord-001734-bbeznd3r	258	12	not	not	RB
cord-001734-bbeznd3r	258	13	only	only	RB
cord-001734-bbeznd3r	258	14	over	over	IN
cord-001734-bbeznd3r	258	15	loop	loop	NN
cord-001734-bbeznd3r	258	16	/	/	SYM
cord-001734-bbeznd3r	258	17	turn	turn	NN
cord-001734-bbeznd3r	258	18	residues	residue	NNS
cord-001734-bbeznd3r	258	19	and	and	CC
cord-001734-bbeznd3r	258	20	C	c	NN
cord-001734-bbeznd3r	258	21	-	-	HYPH
cord-001734-bbeznd3r	258	22	terminal	terminal	NN
cord-001734-bbeznd3r	258	23	residues	residue	NNS
cord-001734-bbeznd3r	258	24	which	which	WDT
cord-001734-bbeznd3r	258	25	include	include	VBP
cord-001734-bbeznd3r	258	26	G29-Leu31	G29-Leu31	NNP
cord-001734-bbeznd3r	258	27	,	,	,
cord-001734-bbeznd3r	258	28	Glu43-Thr45	Glu43-Thr45	NNP
cord-001734-bbeznd3r	258	29	,	,	,
cord-001734-bbeznd3r	258	30	His60-Gly62	His60-Gly62	NNP
cord-001734-bbeznd3r	258	31	,	,	,
cord-001734-bbeznd3r	258	32	Leu85-Val95	Leu85-Val95	NNP
cord-001734-bbeznd3r	258	33	,	,	,
cord-001734-bbeznd3r	258	34	Thr118-Gly121	Thr118-Gly121	NNP
cord-001734-bbeznd3r	258	35	,	,	,
cord-001734-bbeznd3r	258	36	Gly144-Val146	Gly144-Val146	NNP
cord-001734-bbeznd3r	258	37	and	and	CC
cord-001734-bbeznd3r	258	38	Arg157-Gly159	Arg157-Gly159	NNP
cord-001734-bbeznd3r	258	39	;	;	:
cord-001734-bbeznd3r	258	40	but	but	CC
cord-001734-bbeznd3r	258	41	also	also	RB
cord-001734-bbeznd3r	258	42	over	over	IN
cord-001734-bbeznd3r	258	43	the	the	DT
cord-001734-bbeznd3r	258	44	short	short	JJ
cord-001734-bbeznd3r	258	45	helix	helix	NN
cord-001734-bbeznd3r	258	46	Val72-Lys74	Val72-Lys74	NNS
cord-001734-bbeznd3r	258	47	,	,	,
cord-001734-bbeznd3r	258	48	and	and	CC
cord-001734-bbeznd3r	258	49	β	β	NN
cord-001734-bbeznd3r	258	50	-	-	HYPH
cord-001734-bbeznd3r	258	51	strands	strand	NNS
cord-001734-bbeznd3r	258	52	Gly32-Gln35	gly32-gln35	NN
cord-001734-bbeznd3r	258	53	,	,	,
cord-001734-bbeznd3r	258	54	Lys63-Ile65	Lys63-Ile65	NNP
cord-001734-bbeznd3r	258	55	,	,	,
cord-001734-bbeznd3r	258	56	Asp75-Ile77	Asp75-Ile77	NNP
cord-001734-bbeznd3r	258	57	hosting	host	VBG
cord-001734-bbeznd3r	258	58	the	the	DT
cord-001734-bbeznd3r	258	59	catalytic	catalytic	JJ
cord-001734-bbeznd3r	258	60	triad	triad	NN
cord-001734-bbeznd3r	258	61	residue	residue	NN
cord-001734-bbeznd3r	258	62	Asp75	Asp75	NNP
cord-001734-bbeznd3r	258	63	,	,	,
cord-001734-bbeznd3r	258	64	Thr122-Val126	Thr122-Val126	NNP
cord-001734-bbeznd3r	259	1	and	and	CC
cord-001734-bbeznd3r	259	2	Gly159-Val162	Gly159-Val162	NNP
cord-001734-bbeznd3r	260	1	(	(	-LRB-
cord-001734-bbeznd3r	260	2	Fig	Fig	NNP
cord-001734-bbeznd3r	260	3	6D	6D	NNP
cord-001734-bbeznd3r	260	4	and	and	CC
cord-001734-bbeznd3r	260	5	6E	6E	NNP
cord-001734-bbeznd3r	260	6	)	)	-RRB-
cord-001734-bbeznd3r	260	7	.	.	.
cord-001734-bbeznd3r	261	1	Recently	recently	RB
cord-001734-bbeznd3r	261	2	,	,	,
cord-001734-bbeznd3r	261	3	we	-PRON-	PRP
cord-001734-bbeznd3r	261	4	have	have	VBP
cord-001734-bbeznd3r	261	5	deciphered	decipher	VBN
cord-001734-bbeznd3r	261	6	that	that	IN
cord-001734-bbeznd3r	261	7	a	a	DT
cord-001734-bbeznd3r	261	8	global	global	JJ
cord-001734-bbeznd3r	261	9	correlation	correlation	NN
cord-001734-bbeznd3r	261	10	motion	motion	NN
cord-001734-bbeznd3r	261	11	network	network	NN
cord-001734-bbeznd3r	261	12	exists	exist	VBZ
cord-001734-bbeznd3r	261	13	in	in	IN
cord-001734-bbeznd3r	261	14	the	the	DT
cord-001734-bbeznd3r	261	15	SARS	SARS	NNP
cord-001734-bbeznd3r	261	16	3C	3C	NNP
cord-001734-bbeznd3r	261	17	-	-	HYPH
cord-001734-bbeznd3r	261	18	like	like	JJ
cord-001734-bbeznd3r	261	19	protease	protease	NN
cord-001734-bbeznd3r	261	20	[	[	-LRB-
cord-001734-bbeznd3r	261	21	20	20	CD
cord-001734-bbeznd3r	261	22	,	,	,
cord-001734-bbeznd3r	261	23	21	21	CD
cord-001734-bbeznd3r	261	24	]	]	-RRB-
cord-001734-bbeznd3r	261	25	.	.	.
cord-001734-bbeznd3r	262	1	Remarkably	remarkably	RB
cord-001734-bbeznd3r	262	2	,	,	,
cord-001734-bbeznd3r	262	3	a	a	DT
cord-001734-bbeznd3r	262	4	mutation	mutation	NN
cord-001734-bbeznd3r	262	5	N214A	n214a	RB
cord-001734-bbeznd3r	262	6	on	on	IN
cord-001734-bbeznd3r	262	7	the	the	DT
cord-001734-bbeznd3r	262	8	extra	extra	JJ
cord-001734-bbeznd3r	262	9	domain	domain	NN
cord-001734-bbeznd3r	262	10	which	which	WDT
cord-001734-bbeznd3r	262	11	is	be	VBZ
cord-001734-bbeznd3r	262	12	far	far	RB
cord-001734-bbeznd3r	262	13	away	away	RB
cord-001734-bbeznd3r	262	14	from	from	IN
cord-001734-bbeznd3r	262	15	the	the	DT
cord-001734-bbeznd3r	262	16	active	active	JJ
cord-001734-bbeznd3r	262	17	site	site	NN
cord-001734-bbeznd3r	262	18	is	be	VBZ
cord-001734-bbeznd3r	262	19	sufficient	sufficient	JJ
cord-001734-bbeznd3r	262	20	to	to	TO
cord-001734-bbeznd3r	262	21	decouple	decouple	VB
cord-001734-bbeznd3r	262	22	the	the	DT
cord-001734-bbeznd3r	262	23	correlated	correlate	VBN
cord-001734-bbeznd3r	262	24	motions	motion	NNS
cord-001734-bbeznd3r	262	25	and	and	CC
cord-001734-bbeznd3r	262	26	consequently	consequently	RB
cord-001734-bbeznd3r	262	27	leads	lead	VBZ
cord-001734-bbeznd3r	262	28	to	to	IN
cord-001734-bbeznd3r	262	29	the	the	DT
cord-001734-bbeznd3r	262	30	inactivation	inactivation	NN
cord-001734-bbeznd3r	262	31	of	of	IN
cord-001734-bbeznd3r	262	32	the	the	DT
cord-001734-bbeznd3r	262	33	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	262	34	catalysis	catalysis	NN
cord-001734-bbeznd3r	262	35	.	.	.
cord-001734-bbeznd3r	263	1	Here	here	RB
cord-001734-bbeznd3r	263	2	,	,	,
cord-001734-bbeznd3r	263	3	the	the	DT
cord-001734-bbeznd3r	263	4	correlation	correlation	NN
cord-001734-bbeznd3r	263	5	analysis	analysis	NN
cord-001734-bbeznd3r	263	6	of	of	IN
cord-001734-bbeznd3r	263	7	the	the	DT
cord-001734-bbeznd3r	263	8	MD	MD	NNP
cord-001734-bbeznd3r	263	9	simulation	simulation	NN
cord-001734-bbeznd3r	263	10	trajectories	trajectory	NNS
cord-001734-bbeznd3r	263	11	revealed	reveal	VBD
cord-001734-bbeznd3r	263	12	that	that	IN
cord-001734-bbeznd3r	263	13	like	like	IN
cord-001734-bbeznd3r	263	14	the	the	DT
cord-001734-bbeznd3r	263	15	SARS	SARS	NNP
cord-001734-bbeznd3r	263	16	3C	3C	NNP
cord-001734-bbeznd3r	263	17	-	-	HYPH
cord-001734-bbeznd3r	263	18	like	like	JJ
cord-001734-bbeznd3r	263	19	protease	protease	NN
cord-001734-bbeznd3r	263	20	,	,	,
cord-001734-bbeznd3r	263	21	a	a	DT
cord-001734-bbeznd3r	263	22	global	global	JJ
cord-001734-bbeznd3r	263	23	correlation	correlation	NN
cord-001734-bbeznd3r	263	24	network	network	NN
cord-001734-bbeznd3r	263	25	does	do	VBZ
cord-001734-bbeznd3r	263	26	exist	exist	VB
cord-001734-bbeznd3r	263	27	in	in	IN
cord-001734-bbeznd3r	263	28	the	the	DT
cord-001734-bbeznd3r	263	29	NS2B	NS2B	NNP
cord-001734-bbeznd3r	263	30	-	-	HYPH
cord-001734-bbeznd3r	263	31	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	263	32	complex	complex	NN
cord-001734-bbeznd3r	263	33	.	.	.
cord-001734-bbeznd3r	264	1	Most	most	RBS
cord-001734-bbeznd3r	264	2	strikingly	strikingly	RB
cord-001734-bbeznd3r	264	3	,	,	,
cord-001734-bbeznd3r	264	4	in	in	IN
cord-001734-bbeznd3r	264	5	this	this	DT
cord-001734-bbeznd3r	264	6	network	network	NN
cord-001734-bbeznd3r	264	7	,	,	,
cord-001734-bbeznd3r	264	8	the	the	DT
cord-001734-bbeznd3r	264	9	majority	majority	NN
cord-001734-bbeznd3r	264	10	of	of	IN
cord-001734-bbeznd3r	264	11	the	the	DT
cord-001734-bbeznd3r	264	12	significant	significant	JJ
cord-001734-bbeznd3r	264	13	correlated	correlate	VBN
cord-001734-bbeznd3r	264	14	motions	motion	NNS
cord-001734-bbeznd3r	264	15	are	be	VBP
cord-001734-bbeznd3r	264	16	established	establish	VBN
cord-001734-bbeznd3r	264	17	between	between	IN
cord-001734-bbeznd3r	264	18	the	the	DT
cord-001734-bbeznd3r	264	19	cofactor	cofactor	NN
cord-001734-bbeznd3r	264	20	and	and	CC
cord-001734-bbeznd3r	264	21	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	264	22	residues	residue	NNS
cord-001734-bbeznd3r	264	23	(	(	-LRB-
cord-001734-bbeznd3r	264	24	Fig	Fig	NNP
cord-001734-bbeznd3r	264	25	7A	7a	NN
cord-001734-bbeznd3r	264	26	)	)	-RRB-
cord-001734-bbeznd3r	264	27	.	.	.
cord-001734-bbeznd3r	265	1	Surprisingly	surprisingly	RB
cord-001734-bbeznd3r	265	2	,	,	,
cord-001734-bbeznd3r	265	3	although	although	IN
cord-001734-bbeznd3r	265	4	the	the	DT
cord-001734-bbeznd3r	265	5	cofactor	cofactor	NN
cord-001734-bbeznd3r	265	6	residues	residue	NNS
cord-001734-bbeznd3r	265	7	Ser44-Glu63	ser44-glu63	NN
cord-001734-bbeznd3r	265	8	,	,	,
cord-001734-bbeznd3r	265	9	Ser75-Thr94	ser75-thr94	NN
cord-001734-bbeznd3r	265	10	are	be	VBP
cord-001734-bbeznd3r	265	11	highly	highly	RB
cord-001734-bbeznd3r	265	12	dynamic	dynamic	JJ
cord-001734-bbeznd3r	265	13	in	in	IN
cord-001734-bbeznd3r	265	14	the	the	DT
cord-001734-bbeznd3r	265	15	MD	MD	NNP
cord-001734-bbeznd3r	265	16	simulations	simulation	NNS
cord-001734-bbeznd3r	265	17	,	,	,
cord-001734-bbeznd3r	265	18	and	and	CC
cord-001734-bbeznd3r	265	19	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	265	20	are	be	VBP
cord-001734-bbeznd3r	265	21	even	even	RB
cord-001734-bbeznd3r	265	22	missing	miss	VBG
cord-001734-bbeznd3r	265	23	in	in	IN
cord-001734-bbeznd3r	265	24	all	all	DT
cord-001734-bbeznd3r	265	25	crystal	crystal	NN
cord-001734-bbeznd3r	265	26	structures	structure	NNS
cord-001734-bbeznd3r	265	27	of	of	IN
cord-001734-bbeznd3r	265	28	the	the	DT
cord-001734-bbeznd3r	265	29	open	open	JJ
cord-001734-bbeznd3r	265	30	form	form	NN
cord-001734-bbeznd3r	265	31	,	,	,
cord-001734-bbeznd3r	265	32	they	-PRON-	PRP
cord-001734-bbeznd3r	265	33	were	be	VBD
cord-001734-bbeznd3r	265	34	revealed	reveal	VBN
cord-001734-bbeznd3r	265	35	to	to	TO
cord-001734-bbeznd3r	265	36	play	play	VB
cord-001734-bbeznd3r	265	37	a	a	DT
cord-001734-bbeznd3r	265	38	key	key	JJ
cord-001734-bbeznd3r	265	39	role	role	NN
cord-001734-bbeznd3r	265	40	in	in	IN
cord-001734-bbeznd3r	265	41	coordinating	coordinate	VBG
cord-001734-bbeznd3r	265	42	the	the	DT
cord-001734-bbeznd3r	265	43	correlated	correlate	VBN
cord-001734-bbeznd3r	265	44	motions	motion	NNS
cord-001734-bbeznd3r	265	45	with	with	IN
cord-001734-bbeznd3r	265	46	the	the	DT
cord-001734-bbeznd3r	265	47	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	265	48	residues	residue	NNS
cord-001734-bbeznd3r	265	49	Asp20-Gln28	asp20-gln28	JJ
cord-001734-bbeznd3r	265	50	,	,	,
cord-001734-bbeznd3r	265	51	Gly39-Gly44	Gly39-Gly44	NNP
cord-001734-bbeznd3r	265	52	,	,	,
cord-001734-bbeznd3r	265	53	Met59-Glu66	Met59-Glu66	NNP
cord-001734-bbeznd3r	265	54	,	,	,
cord-001734-bbeznd3r	265	55	Ly84-Val95	Ly84-Val95	NNP
cord-001734-bbeznd3r	265	56	,	,	,
cord-001734-bbeznd3r	265	57	Pro106-Gln110	Pro106-Gln110	NNP
cord-001734-bbeznd3r	265	58	,	,	,
cord-001734-bbeznd3r	265	59	and	and	CC
cord-001734-bbeznd3r	265	60	Lys145-Gly148	Lys145-Gly148	NNP
cord-001734-bbeznd3r	265	61	,	,	,
cord-001734-bbeznd3r	265	62	which	which	WDT
cord-001734-bbeznd3r	265	63	cover	cover	VBP
cord-001734-bbeznd3r	265	64	not	not	RB
cord-001734-bbeznd3r	265	65	only	only	RB
cord-001734-bbeznd3r	265	66	the	the	DT
cord-001734-bbeznd3r	265	67	residues	residue	NNS
cord-001734-bbeznd3r	265	68	having	have	VBG
cord-001734-bbeznd3r	265	69	direct	direct	JJ
cord-001734-bbeznd3r	265	70	contacts	contact	NNS
cord-001734-bbeznd3r	265	71	with	with	IN
cord-001734-bbeznd3r	265	72	the	the	DT
cord-001734-bbeznd3r	265	73	cofactor	cofactor	NN
cord-001734-bbeznd3r	265	74	,	,	,
cord-001734-bbeznd3r	265	75	but	but	CC
cord-001734-bbeznd3r	265	76	also	also	RB
cord-001734-bbeznd3r	265	77	residues	residue	NNS
cord-001734-bbeznd3r	265	78	located	locate	VBN
cord-001734-bbeznd3r	265	79	far	far	RB
cord-001734-bbeznd3r	265	80	away	away	RB
cord-001734-bbeznd3r	265	81	from	from	IN
cord-001734-bbeznd3r	265	82	the	the	DT
cord-001734-bbeznd3r	265	83	cofactor	cofactor	NN
cord-001734-bbeznd3r	265	84	(	(	-LRB-
cord-001734-bbeznd3r	265	85	Fig	Fig	NNP
cord-001734-bbeznd3r	265	86	7B	7b	NN
cord-001734-bbeznd3r	265	87	and	and	CC
cord-001734-bbeznd3r	265	88	7C	7C	NNP
cord-001734-bbeznd3r	265	89	)	)	-RRB-
cord-001734-bbeznd3r	265	90	.	.	.
cord-001734-bbeznd3r	266	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	266	2	,	,	,
cord-001734-bbeznd3r	266	3	the	the	DT
cord-001734-bbeznd3r	266	4	global	global	JJ
cord-001734-bbeznd3r	266	5	correlation	correlation	NN
cord-001734-bbeznd3r	266	6	network	network	NN
cord-001734-bbeznd3r	266	7	is	be	VBZ
cord-001734-bbeznd3r	266	8	largely	largely	RB
cord-001734-bbeznd3r	266	9	eliminated	eliminate	VBN
cord-001734-bbeznd3r	266	10	as	as	IN
cord-001734-bbeznd3r	266	11	uncovered	uncover	VBN
cord-001734-bbeznd3r	266	12	by	by	IN
cord-001734-bbeznd3r	266	13	the	the	DT
cord-001734-bbeznd3r	266	14	correlation	correlation	NN
cord-001734-bbeznd3r	266	15	analysis	analysis	NN
cord-001734-bbeznd3r	266	16	of	of	IN
cord-001734-bbeznd3r	266	17	the	the	DT
cord-001734-bbeznd3r	266	18	MD	MD	NNP
cord-001734-bbeznd3r	266	19	trajectories	trajectory	NNS
cord-001734-bbeznd3r	266	20	of	of	IN
cord-001734-bbeznd3r	266	21	the	the	DT
cord-001734-bbeznd3r	266	22	isolated	isolated	JJ
cord-001734-bbeznd3r	266	23	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	266	24	with	with	IN
cord-001734-bbeznd3r	266	25	the	the	DT
cord-001734-bbeznd3r	266	26	NS2B	NS2B	NNP
cord-001734-bbeznd3r	266	27	cofactor	cofactor	NN
cord-001734-bbeznd3r	266	28	removed	remove	VBN
cord-001734-bbeznd3r	266	29	(	(	-LRB-
cord-001734-bbeznd3r	266	30	Fig	Fig	NNP
cord-001734-bbeznd3r	266	31	7D	7D	NNP
cord-001734-bbeznd3r	266	32	)	)	-RRB-
cord-001734-bbeznd3r	266	33	,	,	,
cord-001734-bbeznd3r	266	34	which	which	WDT
cord-001734-bbeznd3r	266	35	is	be	VBZ
cord-001734-bbeznd3r	266	36	similar	similar	JJ
cord-001734-bbeznd3r	266	37	to	to	IN
cord-001734-bbeznd3r	266	38	what	what	WP
cord-001734-bbeznd3r	266	39	was	be	VBD
cord-001734-bbeznd3r	266	40	observed	observe	VBN
cord-001734-bbeznd3r	266	41	on	on	IN
cord-001734-bbeznd3r	266	42	the	the	DT
cord-001734-bbeznd3r	266	43	inactivated	inactivate	VBN
cord-001734-bbeznd3r	266	44	N214A	N214A	NNP
cord-001734-bbeznd3r	266	45	mutant	mutant	NN
cord-001734-bbeznd3r	266	46	of	of	IN
cord-001734-bbeznd3r	266	47	the	the	DT
cord-001734-bbeznd3r	266	48	SARS	SARS	NNP
cord-001734-bbeznd3r	266	49	3C	3C	NNP
cord-001734-bbeznd3r	266	50	-	-	HYPH
cord-001734-bbeznd3r	266	51	like	like	JJ
cord-001734-bbeznd3r	266	52	protease	protease	NN
cord-001734-bbeznd3r	266	53	[	[	-LRB-
cord-001734-bbeznd3r	266	54	19	19	CD
cord-001734-bbeznd3r	266	55	,	,	,
cord-001734-bbeznd3r	266	56	20	20	CD
cord-001734-bbeznd3r	266	57	]	]	-RRB-
cord-001734-bbeznd3r	266	58	.	.	.
cord-001734-bbeznd3r	267	1	Therefore	therefore	RB
cord-001734-bbeznd3r	267	2	,	,	,
cord-001734-bbeznd3r	267	3	as	as	IN
cord-001734-bbeznd3r	267	4	implied	imply	VBN
cord-001734-bbeznd3r	267	5	by	by	IN
cord-001734-bbeznd3r	267	6	our	-PRON-	PRP$
cord-001734-bbeznd3r	267	7	previous	previous	JJ
cord-001734-bbeznd3r	267	8	results	result	NNS
cord-001734-bbeznd3r	267	9	with	with	IN
cord-001734-bbeznd3r	267	10	the	the	DT
cord-001734-bbeznd3r	267	11	SARS	SARS	NNP
cord-001734-bbeznd3r	267	12	3C	3C	NNP
cord-001734-bbeznd3r	267	13	-	-	HYPH
cord-001734-bbeznd3r	267	14	like	like	JJ
cord-001734-bbeznd3r	267	15	protease	protease	NN
cord-001734-bbeznd3r	267	16	,	,	,
cord-001734-bbeznd3r	267	17	slight	slight	JJ
cord-001734-bbeznd3r	267	18	manipulations	manipulation	NNS
cord-001734-bbeznd3r	267	19	of	of	IN
cord-001734-bbeznd3r	267	20	the	the	DT
cord-001734-bbeznd3r	267	21	NS2B	NS2B	NNP
cord-001734-bbeznd3r	267	22	-	-	HYPH
cord-001734-bbeznd3r	267	23	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	267	24	interface	interface	NN
cord-001734-bbeznd3r	267	25	may	may	MD
cord-001734-bbeznd3r	267	26	be	be	VB
cord-001734-bbeznd3r	267	27	sufficient	sufficient	JJ
cord-001734-bbeznd3r	267	28	to	to	TO
cord-001734-bbeznd3r	267	29	decouple	decouple	VB
cord-001734-bbeznd3r	267	30	the	the	DT
cord-001734-bbeznd3r	267	31	correlation	correlation	NN
cord-001734-bbeznd3r	267	32	network	network	NN
cord-001734-bbeznd3r	267	33	to	to	TO
cord-001734-bbeznd3r	267	34	inactivate	inactivate	VB
cord-001734-bbeznd3r	267	35	the	the	DT
cord-001734-bbeznd3r	267	36	activity	activity	NN
cord-001734-bbeznd3r	267	37	of	of	IN
cord-001734-bbeznd3r	267	38	the	the	DT
cord-001734-bbeznd3r	267	39	dengue	dengue	NN
cord-001734-bbeznd3r	267	40	protease	protease	NN
cord-001734-bbeznd3r	267	41	.	.	.
cord-001734-bbeznd3r	268	1	The	the	DT
cord-001734-bbeznd3r	268	2	conformation	conformation	NN
cord-001734-bbeznd3r	268	3	and	and	CC
cord-001734-bbeznd3r	268	4	activity	activity	NN
cord-001734-bbeznd3r	268	5	of	of	IN
cord-001734-bbeznd3r	268	6	the	the	DT
cord-001734-bbeznd3r	268	7	refolded	refolde	VBN
cord-001734-bbeznd3r	268	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	268	9	in	in	IN
cord-001734-bbeznd3r	268	10	complex	complex	NN
cord-001734-bbeznd3r	268	11	with	with	IN
cord-001734-bbeznd3r	268	12	NS2B	NS2B	NNP
cord-001734-bbeznd3r	268	13	(	(	-LRB-
cord-001734-bbeznd3r	268	14	48	48	CD
cord-001734-bbeznd3r	268	15	-	-	SYM
cord-001734-bbeznd3r	268	16	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	268	17	-	-	SYM
cord-001734-bbeznd3r	268	18	84	84	CD
cord-001734-bbeznd3r	268	19	)	)	-RRB-
cord-001734-bbeznd3r	269	1	Although	although	IN
cord-001734-bbeznd3r	269	2	residues	residue	NNS
cord-001734-bbeznd3r	269	3	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	269	4	are	be	VBP
cord-001734-bbeznd3r	269	5	missing	miss	VBG
cord-001734-bbeznd3r	269	6	in	in	IN
cord-001734-bbeznd3r	269	7	all	all	DT
cord-001734-bbeznd3r	269	8	crystal	crystal	NN
cord-001734-bbeznd3r	269	9	structures	structure	NNS
cord-001734-bbeznd3r	269	10	of	of	IN
cord-001734-bbeznd3r	269	11	the	the	DT
cord-001734-bbeznd3r	269	12	open	open	JJ
cord-001734-bbeznd3r	269	13	form	form	NN
cord-001734-bbeznd3r	269	14	,	,	,
cord-001734-bbeznd3r	269	15	they	-PRON-	PRP
cord-001734-bbeznd3r	269	16	were	be	VBD
cord-001734-bbeznd3r	269	17	revealed	reveal	VBN
cord-001734-bbeznd3r	269	18	by	by	IN
cord-001734-bbeznd3r	269	19	MD	MD	NNP
cord-001734-bbeznd3r	269	20	simulations	simulation	NNS
cord-001734-bbeznd3r	269	21	to	to	TO
cord-001734-bbeznd3r	269	22	play	play	VB
cord-001734-bbeznd3r	269	23	a	a	DT
cord-001734-bbeznd3r	269	24	key	key	JJ
cord-001734-bbeznd3r	269	25	role	role	NN
cord-001734-bbeznd3r	269	26	in	in	IN
cord-001734-bbeznd3r	269	27	coordinating	coordinate	VBG
cord-001734-bbeznd3r	269	28	the	the	DT
cord-001734-bbeznd3r	269	29	correlated	correlate	VBN
cord-001734-bbeznd3r	269	30	motions	motion	NNS
cord-001734-bbeznd3r	269	31	with	with	IN
cord-001734-bbeznd3r	269	32	the	the	DT
cord-001734-bbeznd3r	269	33	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	269	34	residues	residue	NNS
cord-001734-bbeznd3r	269	35	.	.	.
cord-001734-bbeznd3r	270	1	Therefore	therefore	RB
cord-001734-bbeznd3r	270	2	,	,	,
cord-001734-bbeznd3r	270	3	we	-PRON-	PRP
cord-001734-bbeznd3r	270	4	generated	generate	VBD
cord-001734-bbeznd3r	270	5	a	a	DT
cord-001734-bbeznd3r	270	6	truncated	truncated	JJ
cord-001734-bbeznd3r	270	7	NS2B	NS2B	NNS
cord-001734-bbeznd3r	270	8	(	(	-LRB-
cord-001734-bbeznd3r	270	9	48	48	CD
cord-001734-bbeznd3r	270	10	-	-	SYM
cord-001734-bbeznd3r	270	11	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	270	12	-	-	SYM
cord-001734-bbeznd3r	270	13	84	84	CD
cord-001734-bbeznd3r	270	14	)	)	-RRB-
cord-001734-bbeznd3r	270	15	in	in	IN
cord-001734-bbeznd3r	270	16	which	which	WDT
cord-001734-bbeznd3r	270	17	the	the	DT
cord-001734-bbeznd3r	270	18	residues	residue	NNS
cord-001734-bbeznd3r	270	19	Thr77-Met84	thr77-met84	NN
cord-001734-bbeznd3r	270	20	were	be	VBD
cord-001734-bbeznd3r	270	21	replaced	replace	VBN
cord-001734-bbeznd3r	270	22	by	by	IN
cord-001734-bbeznd3r	270	23	three	three	CD
cord-001734-bbeznd3r	270	24	Gly	Gly	NNP
cord-001734-bbeznd3r	270	25	residues	residue	NNS
cord-001734-bbeznd3r	270	26	and	and	CC
cord-001734-bbeznd3r	270	27	subsequently	subsequently	RB
cord-001734-bbeznd3r	270	28	conducted	conduct	VBD
cord-001734-bbeznd3r	270	29	the	the	DT
cord-001734-bbeznd3r	270	30	refolding	refolding	NN
cord-001734-bbeznd3r	270	31	of	of	IN
cord-001734-bbeznd3r	270	32	NS2B	NS2B	NNP
cord-001734-bbeznd3r	270	33	(	(	-LRB-
cord-001734-bbeznd3r	270	34	48	48	CD
cord-001734-bbeznd3r	270	35	-	-	SYM
cord-001734-bbeznd3r	270	36	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	270	37	-	-	SYM
cord-001734-bbeznd3r	270	38	84	84	CD
cord-001734-bbeznd3r	270	39	)	)	-RRB-
cord-001734-bbeznd3r	270	40	with	with	IN
cord-001734-bbeznd3r	270	41	NS3pro	NS3pro	NNS
cord-001734-bbeznd3r	270	42	using	use	VBG
cord-001734-bbeznd3r	270	43	the	the	DT
cord-001734-bbeznd3r	270	44	same	same	JJ
cord-001734-bbeznd3r	270	45	protocol	protocol	NN
cord-001734-bbeznd3r	270	46	for	for	IN
cord-001734-bbeznd3r	270	47	refolding	refolde	VBG
cord-001734-bbeznd3r	270	48	of	of	IN
cord-001734-bbeznd3r	270	49	NS2B	NS2B	NNP
cord-001734-bbeznd3r	270	50	.	.	.
cord-001734-bbeznd3r	271	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	271	2	,	,	,
cord-001734-bbeznd3r	271	3	although	although	IN
cord-001734-bbeznd3r	271	4	the	the	DT
cord-001734-bbeznd3r	271	5	isolated	isolated	JJ
cord-001734-bbeznd3r	271	6	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	271	7	is	be	VBZ
cord-001734-bbeznd3r	271	8	completely	completely	RB
cord-001734-bbeznd3r	271	9	insoluble	insoluble	JJ
cord-001734-bbeznd3r	271	10	in	in	IN
cord-001734-bbeznd3r	271	11	buffer	buffer	NN
cord-001734-bbeznd3r	271	12	,	,	,
cord-001734-bbeznd3r	271	13	the	the	DT
cord-001734-bbeznd3r	271	14	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	271	15	became	become	VBD
cord-001734-bbeznd3r	271	16	highly	highly	RB
cord-001734-bbeznd3r	271	17	soluble	soluble	JJ
cord-001734-bbeznd3r	271	18	in	in	IN
cord-001734-bbeznd3r	271	19	buffer	buffer	NN
cord-001734-bbeznd3r	271	20	at	at	IN
cord-001734-bbeznd3r	271	21	pH	pH	NNP
cord-001734-bbeznd3r	271	22	7.5	7.5	CD
cord-001734-bbeznd3r	271	23	in	in	IN
cord-001734-bbeznd3r	271	24	the	the	DT
cord-001734-bbeznd3r	271	25	presence	presence	NN
cord-001734-bbeznd3r	271	26	of	of	IN
cord-001734-bbeznd3r	271	27	NS2B	NS2B	NNP
cord-001734-bbeznd3r	271	28	(	(	-LRB-
cord-001734-bbeznd3r	271	29	48	48	CD
cord-001734-bbeznd3r	271	30	-	-	SYM
cord-001734-bbeznd3r	271	31	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	271	32	-	-	SYM
cord-001734-bbeznd3r	271	33	84	84	CD
cord-001734-bbeznd3r	271	34	)	)	-RRB-
cord-001734-bbeznd3r	271	35	.	.	.
cord-001734-bbeznd3r	272	1	This	this	DT
cord-001734-bbeznd3r	272	2	suggests	suggest	VBZ
cord-001734-bbeznd3r	272	3	that	that	IN
cord-001734-bbeznd3r	272	4	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	272	5	forms	form	VBZ
cord-001734-bbeznd3r	272	6	a	a	DT
cord-001734-bbeznd3r	272	7	complex	complex	NN
cord-001734-bbeznd3r	272	8	with	with	IN
cord-001734-bbeznd3r	272	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	272	10	(	(	-LRB-
cord-001734-bbeznd3r	272	11	48	48	CD
cord-001734-bbeznd3r	272	12	-	-	SYM
cord-001734-bbeznd3r	272	13	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	272	14	-	-	SYM
cord-001734-bbeznd3r	272	15	84	84	CD
cord-001734-bbeznd3r	272	16	)	)	-RRB-
cord-001734-bbeznd3r	272	17	and	and	CC
cord-001734-bbeznd3r	272	18	the	the	DT
cord-001734-bbeznd3r	272	19	complex	complex	NN
cord-001734-bbeznd3r	272	20	is	be	VBZ
cord-001734-bbeznd3r	272	21	soluble	soluble	JJ
cord-001734-bbeznd3r	272	22	in	in	IN
cord-001734-bbeznd3r	272	23	buffer	buffer	NN
cord-001734-bbeznd3r	272	24	.	.	.
cord-001734-bbeznd3r	273	1	Indeed	indeed	RB
cord-001734-bbeznd3r	273	2	,	,	,
cord-001734-bbeznd3r	273	3	as	as	IN
cord-001734-bbeznd3r	273	4	shown	show	VBN
cord-001734-bbeznd3r	273	5	in	in	IN
cord-001734-bbeznd3r	273	6	,	,	,
cord-001734-bbeznd3r	273	7	the	the	DT
cord-001734-bbeznd3r	273	8	decovolution	decovolution	NN
cord-001734-bbeznd3r	273	9	analysis	analysis	NN
cord-001734-bbeznd3r	273	10	of	of	IN
cord-001734-bbeznd3r	273	11	the	the	DT
cord-001734-bbeznd3r	273	12	far	far	JJ
cord-001734-bbeznd3r	273	13	-	-	HYPH
cord-001734-bbeznd3r	273	14	UV	uv	NN
cord-001734-bbeznd3r	273	15	CD	cd	NN
cord-001734-bbeznd3r	273	16	spectrum	spectrum	NN
cord-001734-bbeznd3r	273	17	(	(	-LRB-
cord-001734-bbeznd3r	273	18	Fig	Fig	NNP
cord-001734-bbeznd3r	273	19	8A	8a	NN
cord-001734-bbeznd3r	273	20	)	)	-RRB-
cord-001734-bbeznd3r	273	21	reveals	reveal	VBZ
cord-001734-bbeznd3r	273	22	that	that	IN
cord-001734-bbeznd3r	273	23	the	the	DT
cord-001734-bbeznd3r	273	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	273	25	(	(	-LRB-
cord-001734-bbeznd3r	273	26	48	48	CD
cord-001734-bbeznd3r	273	27	-	-	SYM
cord-001734-bbeznd3r	273	28	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	273	29	-	-	HYPH
cord-001734-bbeznd3r	273	30	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	273	31	complex	complex	NN
cord-001734-bbeznd3r	273	32	contains	contain	VBZ
cord-001734-bbeznd3r	273	33	19	19	CD
cord-001734-bbeznd3r	273	34	%	%	NN
cord-001734-bbeznd3r	273	35	helix	helix	NN
cord-001734-bbeznd3r	273	36	,	,	,
cord-001734-bbeznd3r	273	37	much	much	RB
cord-001734-bbeznd3r	273	38	higher	high	JJR
cord-001734-bbeznd3r	273	39	than	than	IN
cord-001734-bbeznd3r	273	40	those	those	DT
cord-001734-bbeznd3r	273	41	of	of	IN
cord-001734-bbeznd3r	273	42	the	the	DT
cord-001734-bbeznd3r	273	43	isolated	isolated	JJ
cord-001734-bbeznd3r	273	44	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	273	45	(	(	-LRB-
cord-001734-bbeznd3r	273	46	4	4	CD
cord-001734-bbeznd3r	273	47	%	%	NN
cord-001734-bbeznd3r	273	48	)	)	-RRB-
cord-001734-bbeznd3r	273	49	,	,	,
cord-001734-bbeznd3r	273	50	and	and	CC
cord-001734-bbeznd3r	273	51	NS2B	NS2B	NNP
cord-001734-bbeznd3r	273	52	(	(	-LRB-
cord-001734-bbeznd3r	273	53	48	48	CD
cord-001734-bbeznd3r	273	54	-	-	SYM
cord-001734-bbeznd3r	273	55	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	273	56	complex	complex	NN
cord-001734-bbeznd3r	273	57	(	(	-LRB-
cord-001734-bbeznd3r	273	58	8	8	CD
cord-001734-bbeznd3r	273	59	%	%	NN
cord-001734-bbeznd3r	273	60	)	)	-RRB-
cord-001734-bbeznd3r	273	61	.	.	.
cord-001734-bbeznd3r	274	1	On	on	IN
cord-001734-bbeznd3r	274	2	the	the	DT
cord-001734-bbeznd3r	274	3	other	other	JJ
cord-001734-bbeznd3r	274	4	hand	hand	NN
cord-001734-bbeznd3r	274	5	,	,	,
cord-001734-bbeznd3r	274	6	the	the	DT
cord-001734-bbeznd3r	274	7	NS2B	NS2B	NNP
cord-001734-bbeznd3r	274	8	(	(	-LRB-
cord-001734-bbeznd3r	274	9	48	48	CD
cord-001734-bbeznd3r	274	10	-	-	SYM
cord-001734-bbeznd3r	274	11	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	274	12	-	-	HYPH
cord-001734-bbeznd3r	274	13	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	274	14	complex	complex	NN
cord-001734-bbeznd3r	274	15	contains	contain	VBZ
cord-001734-bbeznd3r	274	16	much	much	RB
cord-001734-bbeznd3r	274	17	lower	low	JJR
cord-001734-bbeznd3r	274	18	strand	strand	NN
cord-001734-bbeznd3r	274	19	(	(	-LRB-
cord-001734-bbeznd3r	274	20	8	8	CD
cord-001734-bbeznd3r	274	21	%	%	NN
cord-001734-bbeznd3r	274	22	)	)	-RRB-
cord-001734-bbeznd3r	274	23	but	but	CC
cord-001734-bbeznd3r	274	24	higher	high	JJR
cord-001734-bbeznd3r	274	25	(	(	-LRB-
cord-001734-bbeznd3r	274	26	36	36	CD
cord-001734-bbeznd3r	274	27	%	%	NN
cord-001734-bbeznd3r	274	28	)	)	-RRB-
cord-001734-bbeznd3r	274	29	turn	turn	NN
cord-001734-bbeznd3r	274	30	conformations	conformation	NNS
cord-001734-bbeznd3r	274	31	than	than	IN
cord-001734-bbeznd3r	274	32	the	the	DT
cord-001734-bbeznd3r	274	33	isolated	isolated	JJ
cord-001734-bbeznd3r	274	34	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	274	35	and	and	CC
cord-001734-bbeznd3r	274	36	NS2B	NS2B	NNP
cord-001734-bbeznd3r	274	37	(	(	-LRB-
cord-001734-bbeznd3r	274	38	48	48	CD
cord-001734-bbeznd3r	274	39	-	-	SYM
cord-001734-bbeznd3r	274	40	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	274	41	complex	complex	NN
cord-001734-bbeznd3r	274	42	.	.	.
cord-001734-bbeznd3r	275	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	275	2	,	,	,
cord-001734-bbeznd3r	275	3	the	the	DT
cord-001734-bbeznd3r	275	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	275	5	(	(	-LRB-
cord-001734-bbeznd3r	275	6	48	48	CD
cord-001734-bbeznd3r	275	7	-	-	SYM
cord-001734-bbeznd3r	275	8	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	275	9	-	-	HYPH
cord-001734-bbeznd3r	275	10	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	275	11	complex	complex	NN
cord-001734-bbeznd3r	275	12	has	have	VBZ
cord-001734-bbeznd3r	275	13	~37	~37	NFP
cord-001734-bbeznd3r	275	14	%	%	NN
cord-001734-bbeznd3r	275	15	unstructured	unstructured	JJ
cord-001734-bbeznd3r	275	16	conformation	conformation	NN
cord-001734-bbeznd3r	275	17	,	,	,
cord-001734-bbeznd3r	275	18	slightly	slightly	RB
cord-001734-bbeznd3r	275	19	higher	high	JJR
cord-001734-bbeznd3r	275	20	than	than	IN
cord-001734-bbeznd3r	275	21	that	that	DT
cord-001734-bbeznd3r	275	22	of	of	IN
cord-001734-bbeznd3r	275	23	the	the	DT
cord-001734-bbeznd3r	275	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	275	25	(	(	-LRB-
cord-001734-bbeznd3r	275	26	48	48	CD
cord-001734-bbeznd3r	275	27	-	-	SYM
cord-001734-bbeznd3r	275	28	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	275	29	complex	complex	NN
cord-001734-bbeznd3r	275	30	(	(	-LRB-
cord-001734-bbeznd3r	275	31	31	31	CD
cord-001734-bbeznd3r	275	32	%	%	NN
cord-001734-bbeznd3r	275	33	)	)	-RRB-
cord-001734-bbeznd3r	275	34	,	,	,
cord-001734-bbeznd3r	275	35	but	but	CC
cord-001734-bbeznd3r	275	36	much	much	RB
cord-001734-bbeznd3r	275	37	lower	low	JJR
cord-001734-bbeznd3r	275	38	than	than	IN
cord-001734-bbeznd3r	275	39	that	that	DT
cord-001734-bbeznd3r	275	40	of	of	IN
cord-001734-bbeznd3r	275	41	the	the	DT
cord-001734-bbeznd3r	275	42	isolated	isolated	JJ
cord-001734-bbeznd3r	275	43	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	275	44	(	(	-LRB-
cord-001734-bbeznd3r	275	45	53	53	CD
cord-001734-bbeznd3r	275	46	%	%	NN
cord-001734-bbeznd3r	275	47	)	)	-RRB-
cord-001734-bbeznd3r	275	48	.	.	.
cord-001734-bbeznd3r	276	1	These	these	DT
cord-001734-bbeznd3r	276	2	results	result	NNS
cord-001734-bbeznd3r	276	3	indicate	indicate	VBP
cord-001734-bbeznd3r	276	4	that	that	IN
cord-001734-bbeznd3r	276	5	the	the	DT
cord-001734-bbeznd3r	276	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	276	7	(	(	-LRB-
cord-001734-bbeznd3r	276	8	48	48	CD
cord-001734-bbeznd3r	276	9	-	-	SYM
cord-001734-bbeznd3r	276	10	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	276	11	-	-	HYPH
cord-001734-bbeznd3r	276	12	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	276	13	complex	complex	NN
cord-001734-bbeznd3r	276	14	has	have	VBZ
cord-001734-bbeznd3r	276	15	a	a	DT
cord-001734-bbeznd3r	276	16	very	very	RB
cord-001734-bbeznd3r	276	17	different	different	JJ
cord-001734-bbeznd3r	276	18	structure	structure	NN
cord-001734-bbeznd3r	276	19	from	from	IN
cord-001734-bbeznd3r	276	20	either	either	CC
cord-001734-bbeznd3r	276	21	isolated	isolate	VBN
cord-001734-bbeznd3r	276	22	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	276	23	or	or	CC
cord-001734-bbeznd3r	276	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	276	25	(	(	-LRB-
cord-001734-bbeznd3r	276	26	48	48	CD
cord-001734-bbeznd3r	276	27	-	-	SYM
cord-001734-bbeznd3r	276	28	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	276	29	complex	complex	NN
cord-001734-bbeznd3r	276	30	.	.	.
cord-001734-bbeznd3r	277	1	Indeed	indeed	RB
cord-001734-bbeznd3r	277	2	,	,	,
cord-001734-bbeznd3r	277	3	very	very	RB
cord-001734-bbeznd3r	277	4	different	different	JJ
cord-001734-bbeznd3r	277	5	from	from	IN
cord-001734-bbeznd3r	277	6	the	the	DT
cord-001734-bbeznd3r	277	7	HSQC	HSQC	NNP
cord-001734-bbeznd3r	277	8	spectra	spectra	NN
cord-001734-bbeznd3r	277	9	of	of	IN
cord-001734-bbeznd3r	277	10	the	the	DT
cord-001734-bbeznd3r	277	11	isolated	isolated	JJ
cord-001734-bbeznd3r	277	12	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	277	13	(	(	-LRB-
cord-001734-bbeznd3r	277	14	Fig	fig	NN
cord-001734-bbeznd3r	277	15	1B	1b	CD
cord-001734-bbeznd3r	277	16	)	)	-RRB-
cord-001734-bbeznd3r	277	17	or	or	CC
cord-001734-bbeznd3r	278	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	278	2	(	(	-LRB-
cord-001734-bbeznd3r	278	3	48	48	CD
cord-001734-bbeznd3r	278	4	-	-	SYM
cord-001734-bbeznd3r	278	5	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	278	6	complex	complex	NN
cord-001734-bbeznd3r	278	7	(	(	-LRB-
cord-001734-bbeznd3r	278	8	Fig	Fig	NNP
cord-001734-bbeznd3r	278	9	4D	4d	CD
cord-001734-bbeznd3r	278	10	)	)	-RRB-
cord-001734-bbeznd3r	278	11	,	,	,
cord-001734-bbeznd3r	278	12	only	only	RB
cord-001734-bbeznd3r	278	13	a	a	DT
cord-001734-bbeznd3r	278	14	small	small	JJ
cord-001734-bbeznd3r	278	15	set	set	NN
cord-001734-bbeznd3r	278	16	of	of	IN
cord-001734-bbeznd3r	278	17	HSQC	HSQC	NNP
cord-001734-bbeznd3r	278	18	peaks	peak	NNS
cord-001734-bbeznd3r	278	19	could	could	MD
cord-001734-bbeznd3r	278	20	be	be	VB
cord-001734-bbeznd3r	278	21	detected	detect	VBN
cord-001734-bbeznd3r	278	22	for	for	IN
cord-001734-bbeznd3r	278	23	the	the	DT
cord-001734-bbeznd3r	278	24	15	15	CD
cord-001734-bbeznd3r	278	25	Nlabeled	Nlabeled	NNP
cord-001734-bbeznd3r	278	26	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	278	27	in	in	IN
cord-001734-bbeznd3r	278	28	complex	complex	NN
cord-001734-bbeznd3r	278	29	with	with	IN
cord-001734-bbeznd3r	278	30	NS2B	NS2B	NNP
cord-001734-bbeznd3r	278	31	(	(	-LRB-
cord-001734-bbeznd3r	278	32	48	48	CD
cord-001734-bbeznd3r	278	33	-	-	SYM
cord-001734-bbeznd3r	278	34	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	278	35	-	-	SYM
cord-001734-bbeznd3r	278	36	84	84	CD
cord-001734-bbeznd3r	278	37	)	)	-RRB-
cord-001734-bbeznd3r	278	38	(	(	-LRB-
cord-001734-bbeznd3r	278	39	Fig	Fig	NNP
cord-001734-bbeznd3r	278	40	8B	8b	NN
cord-001734-bbeznd3r	278	41	)	)	-RRB-
cord-001734-bbeznd3r	278	42	.	.	.
cord-001734-bbeznd3r	279	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	279	2	,	,	,
cord-001734-bbeznd3r	279	3	a	a	DT
cord-001734-bbeznd3r	279	4	large	large	JJ
cord-001734-bbeznd3r	279	5	portion	portion	NN
cord-001734-bbeznd3r	279	6	of	of	IN
cord-001734-bbeznd3r	279	7	detectable	detectable	JJ
cord-001734-bbeznd3r	279	8	HSQC	HSQC	NNP
cord-001734-bbeznd3r	279	9	peaks	peak	NNS
cord-001734-bbeznd3r	279	10	are	be	VBP
cord-001734-bbeznd3r	279	11	superimposable	superimposable	JJ
cord-001734-bbeznd3r	279	12	to	to	IN
cord-001734-bbeznd3r	279	13	those	those	DT
cord-001734-bbeznd3r	279	14	of	of	IN
cord-001734-bbeznd3r	279	15	the	the	DT
cord-001734-bbeznd3r	279	16	NS2B	NS2B	NNP
cord-001734-bbeznd3r	279	17	(	(	-LRB-
cord-001734-bbeznd3r	279	18	48	48	CD
cord-001734-bbeznd3r	279	19	-	-	SYM
cord-001734-bbeznd3r	279	20	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	279	21	complex	complex	NN
cord-001734-bbeznd3r	279	22	(	(	-LRB-
cord-001734-bbeznd3r	279	23	Fig	Fig	NNP
cord-001734-bbeznd3r	279	24	8B	8b	NN
cord-001734-bbeznd3r	279	25	)	)	-RRB-
cord-001734-bbeznd3r	279	26	,	,	,
cord-001734-bbeznd3r	279	27	implying	imply	VBG
cord-001734-bbeznd3r	279	28	that	that	IN
cord-001734-bbeznd3r	279	29	some	some	DT
cord-001734-bbeznd3r	279	30	residues	residue	NNS
cord-001734-bbeznd3r	279	31	of	of	IN
cord-001734-bbeznd3r	279	32	the	the	DT
cord-001734-bbeznd3r	279	33	NS2B	NS2B	NNP
cord-001734-bbeznd3r	279	34	(	(	-LRB-
cord-001734-bbeznd3r	279	35	48	48	CD
cord-001734-bbeznd3r	279	36	-	-	SYM
cord-001734-bbeznd3r	279	37	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	279	38	-	-	HYPH
cord-001734-bbeznd3r	279	39	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	279	40	complex	complex	NN
cord-001734-bbeznd3r	279	41	have	have	VBP
cord-001734-bbeznd3r	279	42	conformations	conformation	NNS
cord-001734-bbeznd3r	279	43	similar	similar	JJ
cord-001734-bbeznd3r	279	44	to	to	IN
cord-001734-bbeznd3r	279	45	those	those	DT
cord-001734-bbeznd3r	279	46	of	of	IN
cord-001734-bbeznd3r	279	47	the	the	DT
cord-001734-bbeznd3r	279	48	NS2B	NS2B	NNP
cord-001734-bbeznd3r	279	49	(	(	-LRB-
cord-001734-bbeznd3r	279	50	48	48	CD
cord-001734-bbeznd3r	279	51	-	-	SYM
cord-001734-bbeznd3r	279	52	100)-NS3pro	100)-ns3pro	CD
cord-001734-bbeznd3r	279	53	complex	complex	NN
cord-001734-bbeznd3r	279	54	.	.	.
cord-001734-bbeznd3r	280	1	However	however	RB
cord-001734-bbeznd3r	280	2	,	,	,
cord-001734-bbeznd3r	280	3	HSQC	HSQC	NNP
cord-001734-bbeznd3r	280	4	peaks	peak	NNS
cord-001734-bbeznd3r	280	5	of	of	IN
cord-001734-bbeznd3r	280	6	the	the	DT
cord-001734-bbeznd3r	280	7	majority	majority	NN
cord-001734-bbeznd3r	280	8	of	of	IN
cord-001734-bbeznd3r	280	9	residues	residue	NNS
cord-001734-bbeznd3r	280	10	were	be	VBD
cord-001734-bbeznd3r	280	11	not	not	RB
cord-001734-bbeznd3r	280	12	detected	detect	VBN
cord-001734-bbeznd3r	280	13	,	,	,
cord-001734-bbeznd3r	280	14	indicating	indicate	VBG
cord-001734-bbeznd3r	280	15	that	that	IN
cord-001734-bbeznd3r	280	16	the	the	DT
cord-001734-bbeznd3r	280	17	NS2B	NS2B	NNP
cord-001734-bbeznd3r	280	18	(	(	-LRB-
cord-001734-bbeznd3r	280	19	48	48	CD
cord-001734-bbeznd3r	280	20	-	-	SYM
cord-001734-bbeznd3r	280	21	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	280	22	-	-	HYPH
cord-001734-bbeznd3r	280	23	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	280	24	complex	complex	NN
cord-001734-bbeznd3r	280	25	undergoes	undergo	VBZ
cord-001734-bbeznd3r	280	26	conformational	conformational	JJ
cord-001734-bbeznd3r	280	27	exchanges	exchange	NNS
cord-001734-bbeznd3r	280	28	on	on	IN
cord-001734-bbeznd3r	280	29	μs	μs	NNP
cord-001734-bbeznd3r	280	30	-	-	HYPH
cord-001734-bbeznd3r	280	31	ms	ms	NNP
cord-001734-bbeznd3r	280	32	,	,	,
cord-001734-bbeznd3r	280	33	or	or	CC
cord-001734-bbeznd3r	280	34	/	/	SYM
cord-001734-bbeznd3r	280	35	and	and	CC
cord-001734-bbeznd3r	280	36	dynamic	dynamic	JJ
cord-001734-bbeznd3r	280	37	oligomerization	oligomerization	NN
cord-001734-bbeznd3r	280	38	,	,	,
cord-001734-bbeznd3r	280	39	thus	thus	RB
cord-001734-bbeznd3r	280	40	retarding	retard	VBG
cord-001734-bbeznd3r	280	41	further	far	RBR
cord-001734-bbeznd3r	280	42	NMR	nmr	NN
cord-001734-bbeznd3r	280	43	characterization	characterization	NN
cord-001734-bbeznd3r	280	44	of	of	IN
cord-001734-bbeznd3r	280	45	its	-PRON-	PRP$
cord-001734-bbeznd3r	280	46	high	high	JJ
cord-001734-bbeznd3r	280	47	-	-	HYPH
cord-001734-bbeznd3r	280	48	resolution	resolution	NN
cord-001734-bbeznd3r	280	49	conformation	conformation	NN
cord-001734-bbeznd3r	280	50	.	.	.
cord-001734-bbeznd3r	281	1	Most	most	RBS
cord-001734-bbeznd3r	281	2	strikingly	strikingly	RB
cord-001734-bbeznd3r	281	3	,	,	,
cord-001734-bbeznd3r	281	4	the	the	DT
cord-001734-bbeznd3r	281	5	NS2B	NS2B	NNP
cord-001734-bbeznd3r	281	6	(	(	-LRB-
cord-001734-bbeznd3r	281	7	48	48	CD
cord-001734-bbeznd3r	281	8	-	-	SYM
cord-001734-bbeznd3r	281	9	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	281	10	-	-	HYPH
cord-001734-bbeznd3r	281	11	84)-NS3pro	84)-ns3pro	CD
cord-001734-bbeznd3r	281	12	complex	complex	NN
cord-001734-bbeznd3r	281	13	had	have	VBD
cord-001734-bbeznd3r	281	14	no	no	DT
cord-001734-bbeznd3r	281	15	detectable	detectable	JJ
cord-001734-bbeznd3r	281	16	catalytic	catalytic	JJ
cord-001734-bbeznd3r	281	17	activity	activity	NN
cord-001734-bbeznd3r	281	18	even	even	RB
cord-001734-bbeznd3r	281	19	with	with	IN
cord-001734-bbeznd3r	281	20	a	a	DT
cord-001734-bbeznd3r	281	21	concentration	concentration	NN
cord-001734-bbeznd3r	281	22	up	up	IN
cord-001734-bbeznd3r	281	23	to	to	TO
cord-001734-bbeznd3r	281	24	10	10	CD
cord-001734-bbeznd3r	281	25	μM	μM	NNS
cord-001734-bbeznd3r	281	26	in	in	IN
cord-001734-bbeznd3r	281	27	buffers	buffer	NNS
cord-001734-bbeznd3r	281	28	at	at	IN
cord-001734-bbeznd3r	281	29	pH	pH	NNP
cord-001734-bbeznd3r	281	30	7.5	7.5	CD
cord-001734-bbeznd3r	281	31	,	,	,
cord-001734-bbeznd3r	281	32	suggesting	suggest	VBG
cord-001734-bbeznd3r	281	33	that	that	IN
cord-001734-bbeznd3r	281	34	this	this	DT
cord-001734-bbeznd3r	281	35	complex	complex	NN
cord-001734-bbeznd3r	281	36	is	be	VBZ
cord-001734-bbeznd3r	281	37	trapped	trap	VBN
cord-001734-bbeznd3r	281	38	in	in	IN
cord-001734-bbeznd3r	281	39	a	a	DT
cord-001734-bbeznd3r	281	40	highly	highly	RB
cord-001734-bbeznd3r	281	41	-	-	HYPH
cord-001734-bbeznd3r	281	42	dynamic	dynamic	JJ
cord-001734-bbeznd3r	281	43	and	and	CC
cord-001734-bbeznd3r	281	44	catalytically	catalytically	RB
cord-001734-bbeznd3r	281	45	impotent	impotent	JJ
cord-001734-bbeznd3r	281	46	state	state	NN
cord-001734-bbeznd3r	281	47	.	.	.
cord-001734-bbeznd3r	282	1	As	as	IN
cord-001734-bbeznd3r	282	2	virus	virus	NN
cord-001734-bbeznd3r	282	3	-	-	HYPH
cord-001734-bbeznd3r	282	4	encoded	encode	VBN
cord-001734-bbeznd3r	282	5	proteases	protease	NNS
cord-001734-bbeznd3r	282	6	have	have	VBP
cord-001734-bbeznd3r	282	7	been	be	VBN
cord-001734-bbeznd3r	282	8	shown	show	VBN
cord-001734-bbeznd3r	282	9	to	to	TO
cord-001734-bbeznd3r	282	10	be	be	VB
cord-001734-bbeznd3r	282	11	essential	essential	JJ
cord-001734-bbeznd3r	282	12	for	for	IN
cord-001734-bbeznd3r	282	13	the	the	DT
cord-001734-bbeznd3r	282	14	replication	replication	NN
cord-001734-bbeznd3r	282	15	and	and	CC
cord-001734-bbeznd3r	282	16	infectivity	infectivity	NN
cord-001734-bbeznd3r	282	17	of	of	IN
cord-001734-bbeznd3r	282	18	many	many	JJ
cord-001734-bbeznd3r	282	19	viruses	virus	NNS
cord-001734-bbeznd3r	282	20	,	,	,
cord-001734-bbeznd3r	282	21	consequently	consequently	RB
cord-001734-bbeznd3r	282	22	they	-PRON-	PRP
cord-001734-bbeznd3r	282	23	become	become	VBP
cord-001734-bbeznd3r	282	24	important	important	JJ
cord-001734-bbeznd3r	282	25	targets	target	NNS
cord-001734-bbeznd3r	282	26	for	for	IN
cord-001734-bbeznd3r	282	27	design	design	NN
cord-001734-bbeznd3r	282	28	of	of	IN
cord-001734-bbeznd3r	282	29	anti	anti	JJ
cord-001734-bbeznd3r	282	30	-	-	JJ
cord-001734-bbeznd3r	282	31	viral	viral	JJ
cord-001734-bbeznd3r	282	32	drugs	drug	NNS
cord-001734-bbeznd3r	282	33	[	[	-LRB-
cord-001734-bbeznd3r	282	34	42	42	CD
cord-001734-bbeznd3r	282	35	,	,	,
cord-001734-bbeznd3r	282	36	43	43	CD
cord-001734-bbeznd3r	282	37	]	]	-RRB-
cord-001734-bbeznd3r	282	38	.	.	.
cord-001734-bbeznd3r	283	1	Indeed	indeed	RB
cord-001734-bbeznd3r	283	2	,	,	,
cord-001734-bbeznd3r	283	3	drugs	drug	NNS
cord-001734-bbeznd3r	283	4	have	have	VBP
cord-001734-bbeznd3r	283	5	been	be	VBN
cord-001734-bbeznd3r	283	6	successfully	successfully	RB
cord-001734-bbeznd3r	283	7	developed	develop	VBN
cord-001734-bbeznd3r	283	8	to	to	TO
cord-001734-bbeznd3r	283	9	treat	treat	VB
cord-001734-bbeznd3r	283	10	HIV	HIV	NNP
cord-001734-bbeznd3r	283	11	and	and	CC
cord-001734-bbeznd3r	283	12	HCV	HCV	NNP
cord-001734-bbeznd3r	283	13	infections	infection	NNS
cord-001734-bbeznd3r	283	14	by	by	IN
cord-001734-bbeznd3r	283	15	targeting	target	VBG
cord-001734-bbeznd3r	283	16	their	-PRON-	PRP$
cord-001734-bbeznd3r	283	17	proteases	protease	NNS
cord-001734-bbeznd3r	283	18	[	[	-LRB-
cord-001734-bbeznd3r	283	19	44	44	CD
cord-001734-bbeznd3r	283	20	,	,	,
cord-001734-bbeznd3r	283	21	45	45	CD
cord-001734-bbeznd3r	283	22	]	]	-RRB-
cord-001734-bbeznd3r	283	23	.	.	.
cord-001734-bbeznd3r	284	1	The	the	DT
cord-001734-bbeznd3r	284	2	Dengue	dengue	NN
cord-001734-bbeznd3r	284	3	NS3	ns3	RB
cord-001734-bbeznd3r	284	4	protease	protease	NN
cord-001734-bbeznd3r	284	5	has	have	VBZ
cord-001734-bbeznd3r	284	6	its	-PRON-	PRP$
cord-001734-bbeznd3r	284	7	catalytic	catalytic	JJ
cord-001734-bbeznd3r	284	8	machinery	machinery	NN
cord-001734-bbeznd3r	284	9	hosted	host	VBN
cord-001734-bbeznd3r	284	10	by	by	IN
cord-001734-bbeznd3r	284	11	a	a	DT
cord-001734-bbeznd3r	284	12	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	284	13	fold	fold	NN
cord-001734-bbeznd3r	284	14	,	,	,
cord-001734-bbeznd3r	284	15	which	which	WDT
cord-001734-bbeznd3r	284	16	has	have	VBZ
cord-001734-bbeznd3r	284	17	been	be	VBN
cord-001734-bbeznd3r	284	18	extensively	extensively	RB
cord-001734-bbeznd3r	284	19	shared	share	VBN
cord-001734-bbeznd3r	284	20	by	by	IN
cord-001734-bbeznd3r	284	21	a	a	DT
cord-001734-bbeznd3r	284	22	variety	variety	NN
cord-001734-bbeznd3r	284	23	of	of	IN
cord-001734-bbeznd3r	284	24	proteases	protease	NNS
cord-001734-bbeznd3r	284	25	.	.	.
cord-001734-bbeznd3r	285	1	On	on	IN
cord-001734-bbeznd3r	285	2	the	the	DT
cord-001734-bbeznd3r	285	3	other	other	JJ
cord-001734-bbeznd3r	285	4	hand	hand	NN
cord-001734-bbeznd3r	285	5	,	,	,
cord-001734-bbeznd3r	285	6	unlike	unlike	IN
cord-001734-bbeznd3r	285	7	most	most	JJS
cord-001734-bbeznd3r	285	8	other	other	JJ
cord-001734-bbeznd3r	285	9	chymotrypsin	chymotrypsin	JJ
cord-001734-bbeznd3r	285	10	-	-	HYPH
cord-001734-bbeznd3r	285	11	like	like	JJ
cord-001734-bbeznd3r	285	12	proteases	protease	NNS
cord-001734-bbeznd3r	285	13	,	,	,
cord-001734-bbeznd3r	285	14	only	only	RB
cord-001734-bbeznd3r	285	15	flavivirus	flavivirus	JJ
cord-001734-bbeznd3r	285	16	proteases	protease	NNS
cord-001734-bbeznd3r	285	17	including	include	VBG
cord-001734-bbeznd3r	285	18	dengue	dengue	NN
cord-001734-bbeznd3r	285	19	NS3	ns3	RB
cord-001734-bbeznd3r	285	20	protease	protease	NN
cord-001734-bbeznd3r	285	21	need	need	VB
cord-001734-bbeznd3r	285	22	an	an	DT
cord-001734-bbeznd3r	285	23	additional	additional	JJ
cord-001734-bbeznd3r	285	24	cofactor	cofactor	NN
cord-001734-bbeznd3r	285	25	NS2B	NS2B	NNP
cord-001734-bbeznd3r	285	26	to	to	TO
cord-001734-bbeznd3r	285	27	form	form	VB
cord-001734-bbeznd3r	285	28	the	the	DT
cord-001734-bbeznd3r	285	29	enzymatically	enzymatically	RB
cord-001734-bbeznd3r	285	30	active	active	JJ
cord-001734-bbeznd3r	285	31	complex	complex	NN
cord-001734-bbeznd3r	285	32	.	.	.
cord-001734-bbeznd3r	286	1	Noticeably	noticeably	RB
cord-001734-bbeznd3r	286	2	,	,	,
cord-001734-bbeznd3r	286	3	even	even	RB
cord-001734-bbeznd3r	286	4	within	within	IN
cord-001734-bbeznd3r	286	5	the	the	DT
cord-001734-bbeznd3r	286	6	flavivirus	flavivirus	NNP
cord-001734-bbeznd3r	286	7	proteases	protease	NNS
cord-001734-bbeznd3r	286	8	,	,	,
cord-001734-bbeznd3r	286	9	the	the	DT
cord-001734-bbeznd3r	286	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	286	11	cofactors	cofactor	NNS
cord-001734-bbeznd3r	286	12	are	be	VBP
cord-001734-bbeznd3r	286	13	very	very	RB
cord-001734-bbeznd3r	286	14	divergent	divergent	JJ
cord-001734-bbeznd3r	286	15	,	,	,
cord-001734-bbeznd3r	286	16	only	only	RB
cord-001734-bbeznd3r	286	17	with	with	IN
cord-001734-bbeznd3r	286	18	sequence	sequence	NN
cord-001734-bbeznd3r	286	19	identity	identity	NN
cord-001734-bbeznd3r	286	20	of~19	of~19	NNP
cord-001734-bbeznd3r	286	21	%	%	NN
cord-001734-bbeznd3r	286	22	among	among	IN
cord-001734-bbeznd3r	286	23	different	different	JJ
cord-001734-bbeznd3r	286	24	members	member	NNS
cord-001734-bbeznd3r	286	25	[	[	-LRB-
cord-001734-bbeznd3r	286	26	6	6	CD
cord-001734-bbeznd3r	286	27	]	]	-RRB-
cord-001734-bbeznd3r	286	28	.	.	.
cord-001734-bbeznd3r	287	1	So	so	RB
cord-001734-bbeznd3r	287	2	the	the	DT
cord-001734-bbeznd3r	287	3	NS2B	NS2B	NNP
cord-001734-bbeznd3r	287	4	-	-	HYPH
cord-001734-bbeznd3r	287	5	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	287	6	interface	interface	NN
cord-001734-bbeznd3r	287	7	may	may	MD
cord-001734-bbeznd3r	287	8	represent	represent	VB
cord-001734-bbeznd3r	287	9	an	an	DT
cord-001734-bbeznd3r	287	10	attractive	attractive	JJ
cord-001734-bbeznd3r	287	11	target	target	NN
cord-001734-bbeznd3r	287	12	for	for	IN
cord-001734-bbeznd3r	287	13	developing	develop	VBG
cord-001734-bbeznd3r	287	14	molecules	molecule	NNS
cord-001734-bbeznd3r	287	15	which	which	WDT
cord-001734-bbeznd3r	287	16	specifically	specifically	RB
cord-001734-bbeznd3r	287	17	inhibit	inhibit	VBP
cord-001734-bbeznd3r	287	18	flavivirus	flavivirus	JJ
cord-001734-bbeznd3r	287	19	proteases	protease	NNS
cord-001734-bbeznd3r	287	20	.	.	.
cord-001734-bbeznd3r	288	1	However	however	RB
cord-001734-bbeznd3r	288	2	,	,	,
cord-001734-bbeznd3r	288	3	due	due	IN
cord-001734-bbeznd3r	288	4	to	to	IN
cord-001734-bbeznd3r	288	5	its	-PRON-	PRP$
cord-001734-bbeznd3r	288	6	"	"	``
cord-001734-bbeznd3r	288	7	complete	complete	JJ
cord-001734-bbeznd3r	288	8	insolubility	insolubility	NN
cord-001734-bbeznd3r	288	9	"	"	''
cord-001734-bbeznd3r	288	10	,	,	,
cord-001734-bbeznd3r	288	11	the	the	DT
cord-001734-bbeznd3r	288	12	isolated	isolated	JJ
cord-001734-bbeznd3r	288	13	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	288	14	domain	domain	NN
cord-001734-bbeznd3r	288	15	has	have	VBZ
cord-001734-bbeznd3r	288	16	never	never	RB
cord-001734-bbeznd3r	288	17	been	be	VBN
cord-001734-bbeznd3r	288	18	experimentally	experimentally	RB
cord-001734-bbeznd3r	288	19	characterized	characterize	VBN
cord-001734-bbeznd3r	288	20	so	so	RB
cord-001734-bbeznd3r	288	21	far	far	RB
cord-001734-bbeznd3r	288	22	.	.	.
cord-001734-bbeznd3r	289	1	In	in	IN
cord-001734-bbeznd3r	289	2	the	the	DT
cord-001734-bbeznd3r	289	3	present	present	JJ
cord-001734-bbeznd3r	289	4	study	study	NN
cord-001734-bbeznd3r	289	5	,	,	,
cord-001734-bbeznd3r	289	6	as	as	IN
cord-001734-bbeznd3r	289	7	facilitated	facilitate	VBN
cord-001734-bbeznd3r	289	8	by	by	IN
cord-001734-bbeznd3r	289	9	our	-PRON-	PRP$
cord-001734-bbeznd3r	289	10	discovery	discovery	NN
cord-001734-bbeznd3r	289	11	in	in	IN
cord-001734-bbeznd3r	289	12	2005	2005	CD
cord-001734-bbeznd3r	289	13	[	[	-LRB-
cord-001734-bbeznd3r	289	14	15	15	CD
cord-001734-bbeznd3r	289	15	]	]	-RRB-
cord-001734-bbeznd3r	289	16	[	[	-LRB-
cord-001734-bbeznd3r	289	17	16	16	CD
cord-001734-bbeznd3r	289	18	]	]	-RRB-
cord-001734-bbeznd3r	289	19	[	[	-LRB-
cord-001734-bbeznd3r	289	20	17	17	CD
cord-001734-bbeznd3r	289	21	]	]	-RRB-
cord-001734-bbeznd3r	289	22	[	[	-LRB-
cord-001734-bbeznd3r	289	23	18	18	CD
cord-001734-bbeznd3r	289	24	]	]	-RRB-
cord-001734-bbeznd3r	289	25	[	[	-LRB-
cord-001734-bbeznd3r	289	26	19	19	CD
cord-001734-bbeznd3r	289	27	]	]	-RRB-
cord-001734-bbeznd3r	289	28	,	,	,
cord-001734-bbeznd3r	289	29	for	for	IN
cord-001734-bbeznd3r	289	30	the	the	DT
cord-001734-bbeznd3r	289	31	first	first	JJ
cord-001734-bbeznd3r	289	32	time	time	NN
cord-001734-bbeznd3r	289	33	,	,	,
cord-001734-bbeznd3r	289	34	the	the	DT
cord-001734-bbeznd3r	289	35	isolated	isolated	JJ
cord-001734-bbeznd3r	289	36	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	289	37	domain	domain	NN
cord-001734-bbeznd3r	289	38	has	have	VBZ
cord-001734-bbeznd3r	289	39	been	be	VBN
cord-001734-bbeznd3r	289	40	extensively	extensively	RB
cord-001734-bbeznd3r	289	41	characterized	characterize	VBN
cord-001734-bbeznd3r	289	42	in	in	IN
cord-001734-bbeznd3r	289	43	solution	solution	NN
cord-001734-bbeznd3r	289	44	by	by	IN
cord-001734-bbeznd3r	289	45	CD	CD	NNP
cord-001734-bbeznd3r	289	46	,	,	,
cord-001734-bbeznd3r	289	47	NMR	NMR	NNP
cord-001734-bbeznd3r	289	48	and	and	CC
cord-001734-bbeznd3r	289	49	PRE	PRE	NNP
cord-001734-bbeznd3r	289	50	.	.	.
cord-001734-bbeznd3r	290	1	The	the	DT
cord-001734-bbeznd3r	290	2	results	result	NNS
cord-001734-bbeznd3r	290	3	decipher	decipher	VBP
cord-001734-bbeznd3r	290	4	an	an	DT
cord-001734-bbeznd3r	290	5	unexpected	unexpected	JJ
cord-001734-bbeznd3r	290	6	fact	fact	NN
cord-001734-bbeznd3r	290	7	that	that	IN
cord-001734-bbeznd3r	290	8	despite	despite	IN
cord-001734-bbeznd3r	290	9	owning	own	VBG
cord-001734-bbeznd3r	290	10	a	a	DT
cord-001734-bbeznd3r	290	11	high	high	JJ
cord-001734-bbeznd3r	290	12	-	-	HYPH
cord-001734-bbeznd3r	290	13	complexity	complexity	NN
cord-001734-bbeznd3r	290	14	sequence	sequence	NN
cord-001734-bbeznd3r	290	15	which	which	WDT
cord-001734-bbeznd3r	290	16	is	be	VBZ
cord-001734-bbeznd3r	290	17	very	very	RB
cord-001734-bbeznd3r	290	18	different	different	JJ
cord-001734-bbeznd3r	290	19	from	from	IN
cord-001734-bbeznd3r	290	20	classic	classic	JJ
cord-001734-bbeznd3r	290	21	IUPs	iup	NNS
cord-001734-bbeznd3r	290	22	[	[	-LRB-
cord-001734-bbeznd3r	290	23	31	31	CD
cord-001734-bbeznd3r	290	24	]	]	-RRB-
cord-001734-bbeznd3r	290	25	[	[	-LRB-
cord-001734-bbeznd3r	290	26	32	32	CD
cord-001734-bbeznd3r	290	27	]	]	-RRB-
cord-001734-bbeznd3r	290	28	[	[	-LRB-
cord-001734-bbeznd3r	290	29	33	33	CD
cord-001734-bbeznd3r	290	30	]	]	-RRB-
cord-001734-bbeznd3r	290	31	[	[	-LRB-
cord-001734-bbeznd3r	290	32	34	34	CD
cord-001734-bbeznd3r	290	33	]	]	-RRB-
cord-001734-bbeznd3r	290	34	[	[	-LRB-
cord-001734-bbeznd3r	290	35	35	35	CD
cord-001734-bbeznd3r	290	36	]	]	-RRB-
cord-001734-bbeznd3r	290	37	[	[	-LRB-
cord-001734-bbeznd3r	290	38	36	36	CD
cord-001734-bbeznd3r	290	39	]	]	-RRB-
cord-001734-bbeznd3r	290	40	,	,	,
cord-001734-bbeznd3r	290	41	the	the	DT
cord-001734-bbeznd3r	290	42	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	290	43	with	with	IN
cord-001734-bbeznd3r	290	44	the	the	DT
cord-001734-bbeznd3r	290	45	native	native	JJ
cord-001734-bbeznd3r	290	46	sequence	sequence	NN
cord-001734-bbeznd3r	290	47	is	be	VBZ
cord-001734-bbeznd3r	290	48	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	290	49	disordered	disordered	JJ
cord-001734-bbeznd3r	290	50	without	without	IN
cord-001734-bbeznd3r	290	51	the	the	DT
cord-001734-bbeznd3r	290	52	NS2B	NS2B	NNP
cord-001734-bbeznd3r	290	53	cofactor	cofactor	NN
cord-001734-bbeznd3r	290	54	,	,	,
cord-001734-bbeznd3r	290	55	with	with	IN
cord-001734-bbeznd3r	290	56	no	no	DT
cord-001734-bbeznd3r	290	57	stable	stable	JJ
cord-001734-bbeznd3r	290	58	secondary	secondary	JJ
cord-001734-bbeznd3r	290	59	structures	structure	NNS
cord-001734-bbeznd3r	290	60	and	and	CC
cord-001734-bbeznd3r	290	61	tight	tight	JJ
cord-001734-bbeznd3r	290	62	tertiary	tertiary	JJ
cord-001734-bbeznd3r	290	63	packing	packing	NN
cord-001734-bbeznd3r	290	64	.	.	.
cord-001734-bbeznd3r	291	1	This	this	DT
cord-001734-bbeznd3r	291	2	indicates	indicate	VBZ
cord-001734-bbeznd3r	291	3	that	that	IN
cord-001734-bbeznd3r	291	4	the	the	DT
cord-001734-bbeznd3r	291	5	isolated	isolated	JJ
cord-001734-bbeznd3r	291	6	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	291	7	becomes	become	VBZ
cord-001734-bbeznd3r	291	8	completely	completely	RB
cord-001734-bbeznd3r	291	9	insoluble	insoluble	JJ
cord-001734-bbeznd3r	291	10	in	in	IN
cord-001734-bbeznd3r	291	11	buffers	buffer	NNS
cord-001734-bbeznd3r	291	12	by	by	IN
cord-001734-bbeznd3r	291	13	following	follow	VBG
cord-001734-bbeznd3r	291	14	the	the	DT
cord-001734-bbeznd3r	291	15	same	same	JJ
cord-001734-bbeznd3r	291	16	mechanism	mechanism	NN
cord-001734-bbeznd3r	291	17	as	as	IN
cord-001734-bbeznd3r	291	18	we	-PRON-	PRP
cord-001734-bbeznd3r	291	19	previously	previously	RB
cord-001734-bbeznd3r	291	20	established	establish	VBD
cord-001734-bbeznd3r	291	21	for	for	IN
cord-001734-bbeznd3r	291	22	other	other	JJ
cord-001734-bbeznd3r	291	23	"	"	``
cord-001734-bbeznd3r	291	24	completely	completely	RB
cord-001734-bbeznd3r	291	25	insoluble	insoluble	JJ
cord-001734-bbeznd3r	291	26	"	"	''
cord-001734-bbeznd3r	291	27	proteins	protein	NNS
cord-001734-bbeznd3r	291	28	[	[	-LRB-
cord-001734-bbeznd3r	291	29	15	15	CD
cord-001734-bbeznd3r	291	30	]	]	-RRB-
cord-001734-bbeznd3r	291	31	[	[	-LRB-
cord-001734-bbeznd3r	291	32	16	16	CD
cord-001734-bbeznd3r	291	33	]	]	-RRB-
cord-001734-bbeznd3r	291	34	[	[	-LRB-
cord-001734-bbeznd3r	291	35	17	17	CD
cord-001734-bbeznd3r	291	36	]	]	-RRB-
cord-001734-bbeznd3r	291	37	[	[	-LRB-
cord-001734-bbeznd3r	291	38	18	18	CD
cord-001734-bbeznd3r	291	39	]	]	-RRB-
cord-001734-bbeznd3r	291	40	[	[	-LRB-
cord-001734-bbeznd3r	291	41	19	19	CD
cord-001734-bbeznd3r	291	42	]	]	-RRB-
cord-001734-bbeznd3r	291	43	.	.	.
cord-001734-bbeznd3r	292	1	Nevertheless	nevertheless	RB
cord-001734-bbeznd3r	292	2	,	,	,
cord-001734-bbeznd3r	292	3	in	in	IN
cord-001734-bbeznd3r	292	4	the	the	DT
cord-001734-bbeznd3r	292	5	presence	presence	NN
cord-001734-bbeznd3r	292	6	of	of	IN
cord-001734-bbeznd3r	292	7	the	the	DT
cord-001734-bbeznd3r	292	8	NS2B	NS2B	NNP
cord-001734-bbeznd3r	292	9	cofactor	cofactor	NN
cord-001734-bbeznd3r	292	10	,	,	,
cord-001734-bbeznd3r	292	11	the	the	DT
cord-001734-bbeznd3r	292	12	disordered	disordered	JJ
cord-001734-bbeznd3r	292	13	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	292	14	domain	domain	NN
cord-001734-bbeznd3r	292	15	folds	fold	VBZ
cord-001734-bbeznd3r	292	16	into	into	IN
cord-001734-bbeznd3r	292	17	the	the	DT
cord-001734-bbeznd3r	292	18	well	well	RB
cord-001734-bbeznd3r	292	19	-	-	HYPH
cord-001734-bbeznd3r	292	20	structured	structure	VBN
cord-001734-bbeznd3r	292	21	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	292	22	-	-	HYPH
cord-001734-bbeznd3r	292	23	like	like	IN
cord-001734-bbeznd3r	292	24	fold	fold	NN
cord-001734-bbeznd3r	292	25	hosting	host	VBG
cord-001734-bbeznd3r	292	26	the	the	DT
cord-001734-bbeznd3r	292	27	active	active	JJ
cord-001734-bbeznd3r	292	28	catalytic	catalytic	JJ
cord-001734-bbeznd3r	292	29	machinery	machinery	NN
cord-001734-bbeznd3r	292	30	by	by	IN
cord-001734-bbeznd3r	292	31	the	the	DT
cord-001734-bbeznd3r	292	32	"	"	``
cord-001734-bbeznd3r	292	33	binding	bind	VBG
cord-001734-bbeznd3r	292	34	-	-	HYPH
cord-001734-bbeznd3r	292	35	coupled	coupled	JJ
cord-001734-bbeznd3r	292	36	folding	folding	NN
cord-001734-bbeznd3r	292	37	"	"	''
cord-001734-bbeznd3r	292	38	mechanism	mechanism	NN
cord-001734-bbeznd3r	292	39	[	[	-LRB-
cord-001734-bbeznd3r	292	40	32	32	CD
cord-001734-bbeznd3r	292	41	]	]	-RRB-
cord-001734-bbeznd3r	293	1	[	[	-LRB-
cord-001734-bbeznd3r	293	2	33	33	CD
cord-001734-bbeznd3r	293	3	]	]	-RRB-
cord-001734-bbeznd3r	294	1	[	[	-LRB-
cord-001734-bbeznd3r	294	2	34	34	CD
cord-001734-bbeznd3r	294	3	]	]	-RRB-
cord-001734-bbeznd3r	294	4	[	[	-LRB-
cord-001734-bbeznd3r	294	5	35	35	CD
cord-001734-bbeznd3r	294	6	]	]	-RRB-
cord-001734-bbeznd3r	294	7	[	[	-LRB-
cord-001734-bbeznd3r	294	8	36	36	CD
cord-001734-bbeznd3r	294	9	]	]	-RRB-
cord-001734-bbeznd3r	294	10	.	.	.
cord-001734-bbeznd3r	295	1	Previously	previously	RB
cord-001734-bbeznd3r	295	2	,	,	,
cord-001734-bbeznd3r	295	3	the	the	DT
cord-001734-bbeznd3r	295	4	chymotrypsin	chymotrypsin	NNP
cord-001734-bbeznd3r	295	5	fold	fold	NNP
cord-001734-bbeznd3r	295	6	has	have	VBZ
cord-001734-bbeznd3r	295	7	been	be	VBN
cord-001734-bbeznd3r	295	8	found	find	VBN
cord-001734-bbeznd3r	295	9	to	to	TO
cord-001734-bbeznd3r	295	10	be	be	VB
cord-001734-bbeznd3r	295	11	an	an	DT
cord-001734-bbeznd3r	295	12	autonomous	autonomous	JJ
cord-001734-bbeznd3r	295	13	folding	folding	NN
cord-001734-bbeznd3r	295	14	unit	unit	NN
cord-001734-bbeznd3r	295	15	even	even	RB
cord-001734-bbeznd3r	295	16	in	in	IN
cord-001734-bbeznd3r	295	17	the	the	DT
cord-001734-bbeznd3r	295	18	context	context	NN
cord-001734-bbeznd3r	295	19	of	of	IN
cord-001734-bbeznd3r	295	20	the	the	DT
cord-001734-bbeznd3r	295	21	SARS	SARS	NNP
cord-001734-bbeznd3r	296	1	3Clike	3clike	JJ
cord-001734-bbeznd3r	296	2	protease	protease	RB
cord-001734-bbeznd3r	296	3	with	with	IN
cord-001734-bbeznd3r	296	4	an	an	DT
cord-001734-bbeznd3r	296	5	extra	extra	JJ
cord-001734-bbeznd3r	296	6	domain	domain	NN
cord-001734-bbeznd3r	296	7	[	[	-LRB-
cord-001734-bbeznd3r	296	8	46	46	CD
cord-001734-bbeznd3r	296	9	]	]	-RRB-
cord-001734-bbeznd3r	296	10	.	.	.
cord-001734-bbeznd3r	297	1	Therefore	therefore	RB
cord-001734-bbeznd3r	297	2	,	,	,
cord-001734-bbeznd3r	297	3	to	to	IN
cord-001734-bbeznd3r	297	4	the	the	DT
cord-001734-bbeznd3r	297	5	best	good	JJS
cord-001734-bbeznd3r	297	6	of	of	IN
cord-001734-bbeznd3r	297	7	our	-PRON-	PRP$
cord-001734-bbeznd3r	297	8	knowledge	knowledge	NN
cord-001734-bbeznd3r	297	9	,	,	,
cord-001734-bbeznd3r	297	10	the	the	DT
cord-001734-bbeznd3r	297	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	297	12	domain	domain	NN
cord-001734-bbeznd3r	297	13	represents	represent	VBZ
cord-001734-bbeznd3r	297	14	the	the	DT
cord-001734-bbeznd3r	297	15	first	first	JJ
cord-001734-bbeznd3r	297	16	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	297	17	-	-	HYPH
cord-001734-bbeznd3r	297	18	disordered	disordered	JJ
cord-001734-bbeznd3r	297	19	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	297	20	-	-	HYPH
cord-001734-bbeznd3r	297	21	like	like	JJ
cord-001734-bbeznd3r	297	22	fold	fold	NN
cord-001734-bbeznd3r	297	23	which	which	WDT
cord-001734-bbeznd3r	297	24	absolutely	absolutely	RB
cord-001734-bbeznd3r	297	25	requests	request	VBZ
cord-001734-bbeznd3r	297	26	the	the	DT
cord-001734-bbeznd3r	297	27	additional	additional	JJ
cord-001734-bbeznd3r	297	28	cofactor	cofactor	NN
cord-001734-bbeznd3r	297	29	to	to	TO
cord-001734-bbeznd3r	297	30	achieve	achieve	VB
cord-001734-bbeznd3r	297	31	its	-PRON-	PRP$
cord-001734-bbeznd3r	297	32	correct	correct	JJ
cord-001734-bbeznd3r	297	33	folding	folding	NN
cord-001734-bbeznd3r	297	34	.	.	.
cord-001734-bbeznd3r	298	1	So	so	RB
cord-001734-bbeznd3r	298	2	an	an	DT
cord-001734-bbeznd3r	298	3	interesting	interesting	JJ
cord-001734-bbeznd3r	298	4	question	question	NN
cord-001734-bbeznd3r	298	5	is	be	VBZ
cord-001734-bbeznd3r	298	6	whether	whether	IN
cord-001734-bbeznd3r	298	7	being	be	VBG
cord-001734-bbeznd3r	298	8	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	298	9	disordered	disordered	JJ
cord-001734-bbeznd3r	298	10	for	for	IN
cord-001734-bbeznd3r	298	11	the	the	DT
cord-001734-bbeznd3r	298	12	isolated	isolate	VBN
cord-001734-bbeznd3r	298	13	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	298	14	bears	bear	VBZ
cord-001734-bbeznd3r	298	15	any	any	DT
cord-001734-bbeznd3r	298	16	in	in	IN
cord-001734-bbeznd3r	298	17	vivo	vivo	NN
cord-001734-bbeznd3r	298	18	relevance	relevance	NN
cord-001734-bbeznd3r	298	19	?	?	.
cord-001734-bbeznd3r	299	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	299	2	,	,	,
cord-001734-bbeznd3r	299	3	a	a	DT
cord-001734-bbeznd3r	299	4	recent	recent	JJ
cord-001734-bbeznd3r	299	5	study	study	NN
cord-001734-bbeznd3r	299	6	has	have	VBZ
cord-001734-bbeznd3r	299	7	revealed	reveal	VBN
cord-001734-bbeznd3r	299	8	that	that	IN
cord-001734-bbeznd3r	299	9	the	the	DT
cord-001734-bbeznd3r	299	10	dengue	dengue	NN
cord-001734-bbeznd3r	299	11	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	299	12	domain	domain	NN
cord-001734-bbeznd3r	299	13	without	without	IN
cord-001734-bbeznd3r	299	14	NS2B	NS2B	NNP
cord-001734-bbeznd3r	299	15	was	be	VBD
cord-001734-bbeznd3r	299	16	capable	capable	JJ
cord-001734-bbeznd3r	299	17	of	of	IN
cord-001734-bbeznd3r	299	18	binding	bind	VBG
cord-001734-bbeznd3r	299	19	human	human	JJ
cord-001734-bbeznd3r	299	20	fatty	fatty	JJ
cord-001734-bbeznd3r	299	21	acid	acid	NN
cord-001734-bbeznd3r	299	22	synthase	synthase	NN
cord-001734-bbeznd3r	299	23	(	(	-LRB-
cord-001734-bbeznd3r	299	24	FASN	FASN	NNP
cord-001734-bbeznd3r	299	25	)	)	-RRB-
cord-001734-bbeznd3r	299	26	to	to	TO
cord-001734-bbeznd3r	299	27	trigger	trigger	VB
cord-001734-bbeznd3r	299	28	the	the	DT
cord-001734-bbeznd3r	299	29	membrane	membrane	NN
cord-001734-bbeznd3r	299	30	remodelling	remodelle	VBG
cord-001734-bbeznd3r	299	31	[	[	-LRB-
cord-001734-bbeznd3r	299	32	47	47	CD
cord-001734-bbeznd3r	299	33	]	]	-RRB-
cord-001734-bbeznd3r	299	34	.	.	.
cord-001734-bbeznd3r	300	1	As	as	IN
cord-001734-bbeznd3r	300	2	such	such	JJ
cord-001734-bbeznd3r	300	3	,	,	,
cord-001734-bbeznd3r	300	4	our	-PRON-	PRP$
cord-001734-bbeznd3r	300	5	biophysical	biophysical	JJ
cord-001734-bbeznd3r	300	6	results	result	NNS
cord-001734-bbeznd3r	300	7	imply	imply	VBP
cord-001734-bbeznd3r	300	8	that	that	IN
cord-001734-bbeznd3r	300	9	this	this	DT
cord-001734-bbeznd3r	300	10	interaction	interaction	NN
cord-001734-bbeznd3r	300	11	needs	need	VBZ
cord-001734-bbeznd3r	300	12	the	the	DT
cord-001734-bbeznd3r	300	13	dengue	dengue	NN
cord-001734-bbeznd3r	300	14	NS3pro	ns3pro	VBP
cord-001734-bbeznd3r	300	15	to	to	TO
cord-001734-bbeznd3r	300	16	be	be	VB
cord-001734-bbeznd3r	300	17	largely	largely	RB
cord-001734-bbeznd3r	300	18	disordered	disordered	JJ
cord-001734-bbeznd3r	300	19	.	.	.
cord-001734-bbeznd3r	301	1	Indeed	indeed	RB
cord-001734-bbeznd3r	301	2	,	,	,
cord-001734-bbeznd3r	301	3	we	-PRON-	PRP
cord-001734-bbeznd3r	301	4	found	find	VBD
cord-001734-bbeznd3r	301	5	that	that	IN
cord-001734-bbeznd3r	301	6	the	the	DT
cord-001734-bbeznd3r	301	7	well	well	RB
cord-001734-bbeznd3r	301	8	-	-	HYPH
cord-001734-bbeznd3r	301	9	folded	fold	VBN
cord-001734-bbeznd3r	301	10	NS2B	NS2B	NNP
cord-001734-bbeznd3r	301	11	-	-	HYPH
cord-001734-bbeznd3r	301	12	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	301	13	complex	complex	NN
cord-001734-bbeznd3r	301	14	only	only	RB
cord-001734-bbeznd3r	301	15	had	have	VBD
cord-001734-bbeznd3r	301	16	weak	weak	JJ
cord-001734-bbeznd3r	301	17	binding	binding	NN
cord-001734-bbeznd3r	301	18	to	to	IN
cord-001734-bbeznd3r	301	19	the	the	DT
cord-001734-bbeznd3r	301	20	FASN	FASN	NNP
cord-001734-bbeznd3r	301	21	domain	domain	NN
cord-001734-bbeznd3r	301	22	.	.	.
cord-001734-bbeznd3r	302	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	302	2	,	,	,
cord-001734-bbeznd3r	302	3	DENV	DENV	NNP
cord-001734-bbeznd3r	302	4	and	and	CC
cord-001734-bbeznd3r	302	5	other	other	JJ
cord-001734-bbeznd3r	302	6	members	member	NNS
cord-001734-bbeznd3r	302	7	of	of	IN
cord-001734-bbeznd3r	302	8	the	the	DT
cord-001734-bbeznd3r	302	9	Flaviviridae	Flaviviridae	NNP
cord-001734-bbeznd3r	302	10	family	family	NN
cord-001734-bbeznd3r	302	11	are	be	VBP
cord-001734-bbeznd3r	302	12	dependent	dependent	JJ
cord-001734-bbeznd3r	302	13	on	on	IN
cord-001734-bbeznd3r	302	14	the	the	DT
cord-001734-bbeznd3r	302	15	host	host	NN
cord-001734-bbeznd3r	302	16	ER	er	NN
cord-001734-bbeznd3r	302	17	to	to	TO
cord-001734-bbeznd3r	302	18	translate	translate	VB
cord-001734-bbeznd3r	302	19	,	,	,
cord-001734-bbeznd3r	302	20	replicate	replicate	VB
cord-001734-bbeznd3r	302	21	and	and	CC
cord-001734-bbeznd3r	302	22	package	package	VB
cord-001734-bbeznd3r	302	23	their	-PRON-	PRP$
cord-001734-bbeznd3r	302	24	genome	genome	NN
cord-001734-bbeznd3r	302	25	,	,	,
cord-001734-bbeznd3r	302	26	and	and	CC
cord-001734-bbeznd3r	302	27	their	-PRON-	PRP$
cord-001734-bbeznd3r	302	28	infection	infection	NN
cord-001734-bbeznd3r	302	29	has	have	VBZ
cord-001734-bbeznd3r	302	30	been	be	VBN
cord-001734-bbeznd3r	302	31	found	find	VBN
cord-001734-bbeznd3r	302	32	to	to	TO
cord-001734-bbeznd3r	302	33	induce	induce	VB
cord-001734-bbeznd3r	302	34	significant	significant	JJ
cord-001734-bbeznd3r	302	35	rearrangements	rearrangement	NNS
cord-001734-bbeznd3r	302	36	of	of	IN
cord-001734-bbeznd3r	302	37	intracellular	intracellular	JJ
cord-001734-bbeznd3r	302	38	membranes	membrane	NNS
cord-001734-bbeznd3r	302	39	[	[	-LRB-
cord-001734-bbeznd3r	302	40	47	47	CD
cord-001734-bbeznd3r	302	41	]	]	-RRB-
cord-001734-bbeznd3r	303	1	[	[	-LRB-
cord-001734-bbeznd3r	303	2	48	48	CD
cord-001734-bbeznd3r	303	3	]	]	-RRB-
cord-001734-bbeznd3r	304	1	[	[	-LRB-
cord-001734-bbeznd3r	304	2	49	49	CD
cord-001734-bbeznd3r	304	3	]	]	-RRB-
cord-001734-bbeznd3r	304	4	[	[	-LRB-
cord-001734-bbeznd3r	304	5	50	50	CD
cord-001734-bbeznd3r	304	6	]	]	-RRB-
cord-001734-bbeznd3r	304	7	.	.	.
cord-001734-bbeznd3r	305	1	In	in	IN
cord-001734-bbeznd3r	305	2	particular	particular	JJ
cord-001734-bbeznd3r	305	3	it	-PRON-	PRP
cord-001734-bbeznd3r	305	4	has	have	VBZ
cord-001734-bbeznd3r	305	5	been	be	VBN
cord-001734-bbeznd3r	305	6	recently	recently	RB
cord-001734-bbeznd3r	305	7	revealed	reveal	VBN
cord-001734-bbeznd3r	305	8	that	that	IN
cord-001734-bbeznd3r	305	9	the	the	DT
cord-001734-bbeznd3r	305	10	rearrangement	rearrangement	NN
cord-001734-bbeznd3r	305	11	and	and	CC
cord-001734-bbeznd3r	305	12	expansion	expansion	NN
cord-001734-bbeznd3r	305	13	of	of	IN
cord-001734-bbeznd3r	305	14	the	the	DT
cord-001734-bbeznd3r	305	15	ER	ER	NNP
cord-001734-bbeznd3r	305	16	appear	appear	VBP
cord-001734-bbeznd3r	305	17	to	to	TO
cord-001734-bbeznd3r	305	18	be	be	VB
cord-001734-bbeznd3r	305	19	driven	drive	VBN
cord-001734-bbeznd3r	305	20	by	by	IN
cord-001734-bbeznd3r	305	21	viral	viral	JJ
cord-001734-bbeznd3r	305	22	but	but	CC
cord-001734-bbeznd3r	305	23	not	not	RB
cord-001734-bbeznd3r	305	24	host	host	VB
cord-001734-bbeznd3r	305	25	protein	protein	NN
cord-001734-bbeznd3r	305	26	synthesis	synthesis	NN
cord-001734-bbeznd3r	305	27	early	early	RB
cord-001734-bbeznd3r	305	28	after	after	IN
cord-001734-bbeznd3r	305	29	DENV	DENV	NNP
cord-001734-bbeznd3r	305	30	infection	infection	NN
cord-001734-bbeznd3r	305	31	,	,	,
cord-001734-bbeznd3r	305	32	independently	independently	RB
cord-001734-bbeznd3r	305	33	of	of	IN
cord-001734-bbeznd3r	305	34	the	the	DT
cord-001734-bbeznd3r	305	35	UPR	UPR	NNP
cord-001734-bbeznd3r	305	36	or	or	CC
cord-001734-bbeznd3r	305	37	SREBP2	SREBP2	NNP
cord-001734-bbeznd3r	305	38	pathways	pathway	NNS
cord-001734-bbeznd3r	305	39	[	[	-LRB-
cord-001734-bbeznd3r	305	40	50	50	CD
cord-001734-bbeznd3r	305	41	]	]	-RRB-
cord-001734-bbeznd3r	305	42	.	.	.
cord-001734-bbeznd3r	306	1	Therefore	therefore	RB
cord-001734-bbeznd3r	306	2	,	,	,
cord-001734-bbeznd3r	306	3	on	on	IN
cord-001734-bbeznd3r	306	4	a	a	DT
cord-001734-bbeznd3r	306	5	speculative	speculative	JJ
cord-001734-bbeznd3r	306	6	note	note	NN
cord-001734-bbeznd3r	306	7	,	,	,
cord-001734-bbeznd3r	306	8	we	-PRON-	PRP
cord-001734-bbeznd3r	306	9	propose	propose	VBP
cord-001734-bbeznd3r	306	10	that	that	IN
cord-001734-bbeznd3r	306	11	the	the	DT
cord-001734-bbeznd3r	306	12	highly	highly	RB
cord-001734-bbeznd3r	306	13	disordered	disordered	JJ
cord-001734-bbeznd3r	306	14	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	306	15	itself	-PRON-	PRP
cord-001734-bbeznd3r	306	16	might	may	MD
cord-001734-bbeznd3r	306	17	also	also	RB
cord-001734-bbeznd3r	306	18	play	play	VB
cord-001734-bbeznd3r	306	19	a	a	DT
cord-001734-bbeznd3r	306	20	role	role	NN
cord-001734-bbeznd3r	306	21	in	in	IN
cord-001734-bbeznd3r	306	22	triggering	trigger	VBG
cord-001734-bbeznd3r	306	23	the	the	DT
cord-001734-bbeznd3r	306	24	early	early	JJ
cord-001734-bbeznd3r	306	25	rearrangement	rearrangement	NN
cord-001734-bbeznd3r	306	26	of	of	IN
cord-001734-bbeznd3r	306	27	the	the	DT
cord-001734-bbeznd3r	306	28	ER	ER	NNP
cord-001734-bbeznd3r	306	29	before	before	IN
cord-001734-bbeznd3r	306	30	activating	activate	VBG
cord-001734-bbeznd3r	306	31	specific	specific	JJ
cord-001734-bbeznd3r	306	32	pathways	pathway	NNS
cord-001734-bbeznd3r	306	33	[	[	-LRB-
cord-001734-bbeznd3r	306	34	50	50	CD
cord-001734-bbeznd3r	306	35	]	]	-RRB-
cord-001734-bbeznd3r	306	36	.	.	.
cord-001734-bbeznd3r	307	1	Previously	previously	RB
cord-001734-bbeznd3r	307	2	,	,	,
cord-001734-bbeznd3r	307	3	we	-PRON-	PRP
cord-001734-bbeznd3r	307	4	have	have	VBP
cord-001734-bbeznd3r	307	5	shown	show	VBN
cord-001734-bbeznd3r	307	6	that	that	IN
cord-001734-bbeznd3r	307	7	the	the	DT
cord-001734-bbeznd3r	307	8	ALS	als	NN
cord-001734-bbeznd3r	307	9	-	-	HYPH
cord-001734-bbeznd3r	307	10	causing	cause	VBG
cord-001734-bbeznd3r	307	11	P56S	P56S	NNP
cord-001734-bbeznd3r	307	12	mutation	mutation	NN
cord-001734-bbeznd3r	307	13	of	of	IN
cord-001734-bbeznd3r	307	14	the	the	DT
cord-001734-bbeznd3r	307	15	ER	ER	NNP
cord-001734-bbeznd3r	307	16	-	-	HYPH
cord-001734-bbeznd3r	307	17	anchored	anchor	VBN
cord-001734-bbeznd3r	307	18	VAPB	VAPB	NNP
cord-001734-bbeznd3r	307	19	protein	protein	NN
cord-001734-bbeznd3r	307	20	rendered	render	VBD
cord-001734-bbeznd3r	307	21	the	the	DT
cord-001734-bbeznd3r	307	22	well	well	RB
cord-001734-bbeznd3r	307	23	-	-	HYPH
cord-001734-bbeznd3r	307	24	structured	structure	VBN
cord-001734-bbeznd3r	307	25	β	β	NN
cord-001734-bbeznd3r	307	26	-	-	HYPH
cord-001734-bbeznd3r	307	27	barrel	barrel	NN
cord-001734-bbeznd3r	307	28	fold	fold	NN
cord-001734-bbeznd3r	307	29	of	of	IN
cord-001734-bbeznd3r	307	30	its	-PRON-	PRP$
cord-001734-bbeznd3r	307	31	MSP	MSP	NNP
cord-001734-bbeznd3r	307	32	domain	domain	NN
cord-001734-bbeznd3r	307	33	to	to	TO
cord-001734-bbeznd3r	307	34	be	be	VB
cord-001734-bbeznd3r	307	35	highly	highly	RB
cord-001734-bbeznd3r	307	36	disordered	disordered	JJ
cord-001734-bbeznd3r	307	37	and	and	CC
cord-001734-bbeznd3r	307	38	also	also	RB
cord-001734-bbeznd3r	307	39	become	become	VB
cord-001734-bbeznd3r	307	40	"	"	``
cord-001734-bbeznd3r	307	41	completely	completely	RB
cord-001734-bbeznd3r	307	42	insoluble	insoluble	JJ
cord-001734-bbeznd3r	307	43	"	"	''
cord-001734-bbeznd3r	307	44	in	in	IN
cord-001734-bbeznd3r	307	45	buffer	buffer	NN
cord-001734-bbeznd3r	307	46	[	[	-LRB-
cord-001734-bbeznd3r	307	47	51	51	CD
cord-001734-bbeznd3r	307	48	]	]	-RRB-
cord-001734-bbeznd3r	307	49	,	,	,
cord-001734-bbeznd3r	307	50	similar	similar	JJ
cord-001734-bbeznd3r	307	51	to	to	IN
cord-001734-bbeznd3r	307	52	what	what	WP
cord-001734-bbeznd3r	307	53	we	-PRON-	PRP
cord-001734-bbeznd3r	307	54	found	find	VBD
cord-001734-bbeznd3r	307	55	here	here	RB
cord-001734-bbeznd3r	307	56	on	on	IN
cord-001734-bbeznd3r	307	57	the	the	DT
cord-001734-bbeznd3r	307	58	isolated	isolated	JJ
cord-001734-bbeznd3r	307	59	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	307	60	.	.	.
cord-001734-bbeznd3r	308	1	Remarkably	remarkably	RB
cord-001734-bbeznd3r	308	2	,	,	,
cord-001734-bbeznd3r	308	3	the	the	DT
cord-001734-bbeznd3r	308	4	P56S	p56s	NN
cord-001734-bbeznd3r	308	5	-	-	HYPH
cord-001734-bbeznd3r	308	6	VAPB	VAPB	NNP
cord-001734-bbeznd3r	308	7	suddenly	suddenly	RB
cord-001734-bbeznd3r	308	8	gained	gain	VBD
cord-001734-bbeznd3r	308	9	the	the	DT
cord-001734-bbeznd3r	308	10	novel	novel	JJ
cord-001734-bbeznd3r	308	11	capacity	capacity	NN
cord-001734-bbeznd3r	308	12	to	to	TO
cord-001734-bbeznd3r	308	13	remodel	remodel	VB
cord-001734-bbeznd3r	308	14	the	the	DT
cord-001734-bbeznd3r	308	15	ER	ER	NNP
cord-001734-bbeznd3r	308	16	structure	structure	NN
cord-001734-bbeznd3r	308	17	which	which	WDT
cord-001734-bbeznd3r	308	18	was	be	VBD
cord-001734-bbeznd3r	308	19	not	not	RB
cord-001734-bbeznd3r	308	20	observed	observe	VBN
cord-001734-bbeznd3r	308	21	for	for	IN
cord-001734-bbeznd3r	308	22	the	the	DT
cord-001734-bbeznd3r	308	23	wild	wild	JJ
cord-001734-bbeznd3r	308	24	-	-	HYPH
cord-001734-bbeznd3r	308	25	type	type	NN
cord-001734-bbeznd3r	308	26	VAPB	VAPB	NNP
cord-001734-bbeznd3r	308	27	[	[	-LRB-
cord-001734-bbeznd3r	308	28	52	52	CD
cord-001734-bbeznd3r	308	29	]	]	-RRB-
cord-001734-bbeznd3r	308	30	.	.	.
cord-001734-bbeznd3r	309	1	Therefore	therefore	RB
cord-001734-bbeznd3r	309	2	,	,	,
cord-001734-bbeznd3r	309	3	the	the	DT
cord-001734-bbeznd3r	309	4	disordered	disordered	JJ
cord-001734-bbeznd3r	309	5	human	human	JJ
cord-001734-bbeznd3r	309	6	P56S	p56s	NN
cord-001734-bbeznd3r	309	7	-	-	HYPH
cord-001734-bbeznd3r	309	8	VAPB	vapb	NN
cord-001734-bbeznd3r	309	9	and	and	CC
cord-001734-bbeznd3r	309	10	dengue	dengue	NN
cord-001734-bbeznd3r	309	11	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	309	12	may	may	MD
cord-001734-bbeznd3r	309	13	use	use	VB
cord-001734-bbeznd3r	309	14	similar	similar	JJ
cord-001734-bbeznd3r	309	15	mechanisms	mechanism	NNS
cord-001734-bbeznd3r	309	16	to	to	TO
cord-001734-bbeznd3r	309	17	remodel	remodel	VB
cord-001734-bbeznd3r	309	18	the	the	DT
cord-001734-bbeznd3r	309	19	ER	ER	NNP
cord-001734-bbeznd3r	309	20	structure	structure	NN
cord-001734-bbeznd3r	309	21	.	.	.
cord-001734-bbeznd3r	310	1	In	in	IN
cord-001734-bbeznd3r	310	2	fact	fact	NN
cord-001734-bbeznd3r	310	3	,	,	,
cord-001734-bbeznd3r	310	4	the	the	DT
cord-001734-bbeznd3r	310	5	degue	degue	NN
cord-001734-bbeznd3r	310	6	NS3	ns3	RB
cord-001734-bbeznd3r	310	7	protein	protein	NN
cord-001734-bbeznd3r	310	8	itself	-PRON-	PRP
cord-001734-bbeznd3r	310	9	is	be	VBZ
cord-001734-bbeznd3r	310	10	also	also	RB
cord-001734-bbeznd3r	310	11	anchored	anchor	VBN
cord-001734-bbeznd3r	310	12	into	into	IN
cord-001734-bbeznd3r	310	13	the	the	DT
cord-001734-bbeznd3r	310	14	ER	ER	NNP
cord-001734-bbeznd3r	310	15	membrane	membrane	NN
cord-001734-bbeznd3r	310	16	before	before	IN
cord-001734-bbeznd3r	310	17	NS3	ns3	RB
cord-001734-bbeznd3r	310	18	forms	form	VBZ
cord-001734-bbeznd3r	310	19	the	the	DT
cord-001734-bbeznd3r	310	20	catalytically	catalytically	RB
cord-001734-bbeznd3r	310	21	-	-	HYPH
cord-001734-bbeznd3r	310	22	active	active	JJ
cord-001734-bbeznd3r	310	23	complex	complex	NN
cord-001734-bbeznd3r	310	24	with	with	IN
cord-001734-bbeznd3r	310	25	NS2B	NS2B	NNP
cord-001734-bbeznd3r	310	26	to	to	TO
cord-001734-bbeznd3r	310	27	cleave	cleave	VB
cord-001734-bbeznd3r	310	28	itself	-PRON-	PRP
cord-001734-bbeznd3r	310	29	from	from	IN
cord-001734-bbeznd3r	310	30	the	the	DT
cord-001734-bbeznd3r	310	31	polyprotein	polyprotein	NN
cord-001734-bbeznd3r	310	32	.	.	.
cord-001734-bbeznd3r	311	1	In	in	IN
cord-001734-bbeznd3r	311	2	this	this	DT
cord-001734-bbeznd3r	311	3	study	study	NN
cord-001734-bbeznd3r	311	4	,	,	,
cord-001734-bbeznd3r	311	5	with	with	IN
cord-001734-bbeznd3r	311	6	our	-PRON-	PRP$
cord-001734-bbeznd3r	311	7	previous	previous	JJ
cord-001734-bbeznd3r	311	8	discovery	discovery	NN
cord-001734-bbeznd3r	311	9	that	that	IN
cord-001734-bbeznd3r	311	10	"	"	``
cord-001734-bbeznd3r	311	11	insoluble	insoluble	JJ
cord-001734-bbeznd3r	311	12	proteins	protein	NNS
cord-001734-bbeznd3r	311	13	could	could	MD
cord-001734-bbeznd3r	311	14	be	be	VB
cord-001734-bbeznd3r	311	15	solubilized	solubilize	VBN
cord-001734-bbeznd3r	311	16	in	in	IN
cord-001734-bbeznd3r	311	17	water	water	NN
cord-001734-bbeznd3r	311	18	with	with	IN
cord-001734-bbeznd3r	311	19	minimized	minimize	VBN
cord-001734-bbeznd3r	311	20	salt	salt	NN
cord-001734-bbeznd3r	311	21	ions	ion	NNS
cord-001734-bbeznd3r	311	22	,	,	,
cord-001734-bbeznd3r	311	23	we	-PRON-	PRP
cord-001734-bbeznd3r	311	24	also	also	RB
cord-001734-bbeznd3r	311	25	successfully	successfully	RB
cord-001734-bbeznd3r	311	26	refolded	refolde	VBD
cord-001734-bbeznd3r	311	27	the	the	DT
cord-001734-bbeznd3r	311	28	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	311	29	protease	protease	NN
cord-001734-bbeznd3r	311	30	with	with	IN
cord-001734-bbeznd3r	311	31	the	the	DT
cord-001734-bbeznd3r	311	32	fulllength	fulllength	NN
cord-001734-bbeznd3r	311	33	NS2B	NS2B	NNP
cord-001734-bbeznd3r	311	34	(	(	-LRB-
cord-001734-bbeznd3r	311	35	1	1	CD
cord-001734-bbeznd3r	311	36	-	-	SYM
cord-001734-bbeznd3r	311	37	130	130	CD
cord-001734-bbeznd3r	311	38	)	)	-RRB-
cord-001734-bbeznd3r	311	39	anchored	anchor	VBD
cord-001734-bbeznd3r	311	40	into	into	IN
cord-001734-bbeznd3r	311	41	the	the	DT
cord-001734-bbeznd3r	311	42	LMPC	LMPC	NNP
cord-001734-bbeznd3r	311	43	micelle	micelle	NN
cord-001734-bbeznd3r	311	44	.	.	.
cord-001734-bbeznd3r	312	1	Interestingly	interestingly	RB
cord-001734-bbeznd3r	312	2	,	,	,
cord-001734-bbeznd3r	312	3	although	although	IN
cord-001734-bbeznd3r	312	4	NMR	NMR	NNP
cord-001734-bbeznd3r	312	5	characterization	characterization	NN
cord-001734-bbeznd3r	312	6	deciphers	decipher	VBZ
cord-001734-bbeznd3r	312	7	that	that	IN
cord-001734-bbeznd3r	312	8	the	the	DT
cord-001734-bbeznd3r	312	9	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	312	10	domains	domain	NNS
cord-001734-bbeznd3r	312	11	have	have	VBP
cord-001734-bbeznd3r	312	12	different	different	JJ
cord-001734-bbeznd3r	312	13	dynamics	dynamic	NNS
cord-001734-bbeznd3r	312	14	on	on	IN
cord-001734-bbeznd3r	312	15	the	the	DT
cord-001734-bbeznd3r	312	16	μs	μs	NNP
cord-001734-bbeznd3r	312	17	-	-	HYPH
cord-001734-bbeznd3r	312	18	ms	ms	NNP
cord-001734-bbeznd3r	312	19	time	time	NN
cord-001734-bbeznd3r	312	20	scale	scale	NN
cord-001734-bbeznd3r	312	21	in	in	IN
cord-001734-bbeznd3r	312	22	the	the	DT
cord-001734-bbeznd3r	312	23	contexts	contexts	NN
cord-001734-bbeznd3r	312	24	of	of	IN
cord-001734-bbeznd3r	312	25	being	be	VBG
cord-001734-bbeznd3r	312	26	complexed	complexe	VBN
cord-001734-bbeznd3r	312	27	with	with	IN
cord-001734-bbeznd3r	312	28	NS	NS	NNP
cord-001734-bbeznd3r	312	29	(	(	-LRB-
cord-001734-bbeznd3r	312	30	48	48	CD
cord-001734-bbeznd3r	312	31	-	-	SYM
cord-001734-bbeznd3r	312	32	100	100	CD
cord-001734-bbeznd3r	312	33	)	)	-RRB-
cord-001734-bbeznd3r	312	34	in	in	IN
cord-001734-bbeznd3r	312	35	buffer	buffer	NN
cord-001734-bbeznd3r	312	36	and	and	CC
cord-001734-bbeznd3r	312	37	with	with	IN
cord-001734-bbeznd3r	312	38	NS2B	NS2B	NNP
cord-001734-bbeznd3r	312	39	(	(	-LRB-
cord-001734-bbeznd3r	312	40	1	1	CD
cord-001734-bbeznd3r	312	41	-	-	SYM
cord-001734-bbeznd3r	312	42	130	130	CD
cord-001734-bbeznd3r	312	43	)	)	-RRB-
cord-001734-bbeznd3r	312	44	in	in	IN
cord-001734-bbeznd3r	312	45	the	the	DT
cord-001734-bbeznd3r	312	46	LMPC	LMPC	NNP
cord-001734-bbeznd3r	312	47	micelle	micelle	NN
cord-001734-bbeznd3r	312	48	,	,	,
cord-001734-bbeznd3r	312	49	they	-PRON-	PRP
cord-001734-bbeznd3r	312	50	have	have	VBP
cord-001734-bbeznd3r	312	51	very	very	RB
cord-001734-bbeznd3r	312	52	similar	similar	JJ
cord-001734-bbeznd3r	312	53	enzymatic	enzymatic	JJ
cord-001734-bbeznd3r	312	54	activities	activity	NNS
cord-001734-bbeznd3r	312	55	.	.	.
cord-001734-bbeznd3r	313	1	This	this	DT
cord-001734-bbeznd3r	313	2	membrane	membrane	NN
cord-001734-bbeznd3r	313	3	-	-	HYPH
cord-001734-bbeznd3r	313	4	anchored	anchor	VBN
cord-001734-bbeznd3r	313	5	complex	complex	NN
cord-001734-bbeznd3r	313	6	may	may	MD
cord-001734-bbeznd3r	313	7	provide	provide	VB
cord-001734-bbeznd3r	313	8	a	a	DT
cord-001734-bbeznd3r	313	9	platform	platform	NN
cord-001734-bbeznd3r	313	10	for	for	IN
cord-001734-bbeznd3r	313	11	screening	screen	VBG
cord-001734-bbeznd3r	313	12	the	the	DT
cord-001734-bbeznd3r	313	13	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	313	14	for	for	IN
cord-001734-bbeznd3r	313	15	the	the	DT
cord-001734-bbeznd3r	313	16	dengue	dengue	NN
cord-001734-bbeznd3r	313	17	protease	protease	NN
cord-001734-bbeznd3r	313	18	.	.	.
cord-001734-bbeznd3r	314	1	In	in	IN
cord-001734-bbeznd3r	314	2	this	this	DT
cord-001734-bbeznd3r	314	3	regard	regard	NN
cord-001734-bbeznd3r	314	4	,	,	,
cord-001734-bbeznd3r	314	5	despite	despite	IN
cord-001734-bbeznd3r	314	6	challenging	challenge	VBG
cord-001734-bbeznd3r	314	7	,	,	,
cord-001734-bbeznd3r	314	8	it	-PRON-	PRP
cord-001734-bbeznd3r	314	9	is	be	VBZ
cord-001734-bbeznd3r	314	10	of	of	IN
cord-001734-bbeznd3r	314	11	both	both	CC
cord-001734-bbeznd3r	314	12	fundamental	fundamental	JJ
cord-001734-bbeznd3r	314	13	and	and	CC
cord-001734-bbeznd3r	314	14	therapeutic	therapeutic	JJ
cord-001734-bbeznd3r	314	15	interest	interest	NN
cord-001734-bbeznd3r	314	16	in	in	IN
cord-001734-bbeznd3r	314	17	the	the	DT
cord-001734-bbeznd3r	314	18	future	future	NN
cord-001734-bbeznd3r	314	19	to	to	TO
cord-001734-bbeznd3r	314	20	explore	explore	VB
cord-001734-bbeznd3r	314	21	how	how	WRB
cord-001734-bbeznd3r	314	22	the	the	DT
cord-001734-bbeznd3r	314	23	different	different	JJ
cord-001734-bbeznd3r	314	24	structures	structure	NNS
cord-001734-bbeznd3r	314	25	and	and	CC
cord-001734-bbeznd3r	314	26	dynamics	dynamic	NNS
cord-001734-bbeznd3r	314	27	upon	upon	IN
cord-001734-bbeznd3r	314	28	being	be	VBG
cord-001734-bbeznd3r	314	29	anchored	anchor	VBN
cord-001734-bbeznd3r	314	30	into	into	IN
cord-001734-bbeznd3r	314	31	membranes	membrane	NNS
cord-001734-bbeznd3r	314	32	affect	affect	VBP
cord-001734-bbeznd3r	314	33	the	the	DT
cord-001734-bbeznd3r	314	34	affinity	affinity	NN
cord-001734-bbeznd3r	314	35	and	and	CC
cord-001734-bbeznd3r	314	36	specificity	specificity	NN
cord-001734-bbeznd3r	314	37	of	of	IN
cord-001734-bbeznd3r	314	38	the	the	DT
cord-001734-bbeznd3r	314	39	dengue	dengue	NN
cord-001734-bbeznd3r	314	40	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	314	41	in	in	IN
cord-001734-bbeznd3r	314	42	binding	bind	VBG
cord-001734-bbeznd3r	314	43	substrates	substrate	NNS
cord-001734-bbeznd3r	314	44	and	and	CC
cord-001734-bbeznd3r	314	45	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	314	46	.	.	.
cord-001734-bbeznd3r	315	1	Further	further	JJ
cord-001734-bbeznd3r	315	2	MD	MD	NNP
cord-001734-bbeznd3r	315	3	simulations	simulation	NNS
cord-001734-bbeznd3r	315	4	provide	provide	VBP
cord-001734-bbeznd3r	315	5	critical	critical	JJ
cord-001734-bbeznd3r	315	6	insights	insight	NNS
cord-001734-bbeznd3r	315	7	into	into	IN
cord-001734-bbeznd3r	315	8	the	the	DT
cord-001734-bbeznd3r	315	9	indispensable	indispensable	JJ
cord-001734-bbeznd3r	315	10	role	role	NN
cord-001734-bbeznd3r	315	11	of	of	IN
cord-001734-bbeznd3r	315	12	the	the	DT
cord-001734-bbeznd3r	315	13	NS2B	NS2B	NNP
cord-001734-bbeznd3r	315	14	cofactor	cofactor	NN
cord-001734-bbeznd3r	315	15	.	.	.
cord-001734-bbeznd3r	316	1	Even	even	RB
cord-001734-bbeznd3r	316	2	within	within	IN
cord-001734-bbeznd3r	316	3	20-ns	20-ns	CD
cord-001734-bbeznd3r	316	4	simulations	simulation	NNS
cord-001734-bbeznd3r	316	5	,	,	,
cord-001734-bbeznd3r	316	6	the	the	DT
cord-001734-bbeznd3r	316	7	isolated	isolated	JJ
cord-001734-bbeznd3r	316	8	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	316	9	domain	domain	NN
cord-001734-bbeznd3r	316	10	already	already	RB
cord-001734-bbeznd3r	316	11	showed	show	VBD
cord-001734-bbeznd3r	316	12	higher	high	JJR
cord-001734-bbeznd3r	316	13	dynamic	dynamic	JJ
cord-001734-bbeznd3r	316	14	instability	instability	NN
cord-001734-bbeznd3r	316	15	than	than	IN
cord-001734-bbeznd3r	316	16	the	the	DT
cord-001734-bbeznd3r	316	17	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	316	18	domain	domain	NN
cord-001734-bbeznd3r	316	19	in	in	IN
cord-001734-bbeznd3r	316	20	the	the	DT
cord-001734-bbeznd3r	316	21	NS2B	NS2B	NNP
cord-001734-bbeznd3r	316	22	-	-	HYPH
cord-001734-bbeznd3r	316	23	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	316	24	complex	complex	NN
cord-001734-bbeznd3r	316	25	(	(	-LRB-
cord-001734-bbeznd3r	316	26	Fig	Fig	NNP
cord-001734-bbeznd3r	316	27	5F	5f	NN
cord-001734-bbeznd3r	316	28	)	)	-RRB-
cord-001734-bbeznd3r	316	29	.	.	.
cord-001734-bbeznd3r	317	1	It	-PRON-	PRP
cord-001734-bbeznd3r	317	2	is	be	VBZ
cord-001734-bbeznd3r	317	3	thus	thus	RB
cord-001734-bbeznd3r	317	4	expected	expect	VBN
cord-001734-bbeznd3r	317	5	that	that	IN
cord-001734-bbeznd3r	317	6	on	on	IN
cord-001734-bbeznd3r	317	7	the	the	DT
cord-001734-bbeznd3r	317	8	long	long	JJ
cord-001734-bbeznd3r	317	9	time	time	NN
cord-001734-bbeznd3r	317	10	scale	scale	NN
cord-001734-bbeznd3r	317	11	,	,	,
cord-001734-bbeznd3r	317	12	the	the	DT
cord-001734-bbeznd3r	317	13	isolated	isolated	JJ
cord-001734-bbeznd3r	317	14	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	317	15	would	would	MD
cord-001734-bbeznd3r	317	16	become	become	VB
cord-001734-bbeznd3r	317	17	unfolded	unfold	VBN
cord-001734-bbeznd3r	317	18	as	as	IN
cord-001734-bbeznd3r	317	19	experimentally	experimentally	RB
cord-001734-bbeznd3r	317	20	demonstrated	demonstrate	VBN
cord-001734-bbeznd3r	317	21	here	here	RB
cord-001734-bbeznd3r	317	22	.	.	.
cord-001734-bbeznd3r	318	1	Strikingly	strikingly	RB
cord-001734-bbeznd3r	318	2	,	,	,
cord-001734-bbeznd3r	318	3	the	the	DT
cord-001734-bbeznd3r	318	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	318	5	residues	residue	NNS
cord-001734-bbeznd3r	318	6	show	show	VBP
cord-001734-bbeznd3r	318	7	much	much	RB
cord-001734-bbeznd3r	318	8	higher	high	JJR
cord-001734-bbeznd3r	318	9	structural	structural	JJ
cord-001734-bbeznd3r	318	10	dynamics	dynamic	NNS
cord-001734-bbeznd3r	318	11	than	than	IN
cord-001734-bbeznd3r	318	12	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	318	13	even	even	RB
cord-001734-bbeznd3r	318	14	in	in	IN
cord-001734-bbeznd3r	318	15	the	the	DT
cord-001734-bbeznd3r	318	16	complex	complex	NN
cord-001734-bbeznd3r	318	17	,	,	,
cord-001734-bbeznd3r	318	18	suggesting	suggest	VBG
cord-001734-bbeznd3r	318	19	that	that	IN
cord-001734-bbeznd3r	318	20	the	the	DT
cord-001734-bbeznd3r	318	21	cofactor	cofactor	NN
cord-001734-bbeznd3r	318	22	is	be	VBZ
cord-001734-bbeznd3r	318	23	capable	capable	JJ
cord-001734-bbeznd3r	318	24	of	of	IN
cord-001734-bbeznd3r	318	25	sampling	sample	VBG
cord-001734-bbeznd3r	318	26	a	a	DT
cord-001734-bbeznd3r	318	27	large	large	JJ
cord-001734-bbeznd3r	318	28	ensemble	ensemble	NN
cord-001734-bbeznd3r	318	29	of	of	IN
cord-001734-bbeznd3r	318	30	conformations	conformation	NNS
cord-001734-bbeznd3r	318	31	,	,	,
cord-001734-bbeznd3r	318	32	thus	thus	RB
cord-001734-bbeznd3r	318	33	providing	provide	VBG
cord-001734-bbeznd3r	318	34	the	the	DT
cord-001734-bbeznd3r	318	35	dynamic	dynamic	JJ
cord-001734-bbeznd3r	318	36	mechanism	mechanism	NN
cord-001734-bbeznd3r	318	37	for	for	IN
cord-001734-bbeznd3r	318	38	the	the	DT
cord-001734-bbeznd3r	318	39	observed	observed	JJ
cord-001734-bbeznd3r	318	40	conformational	conformational	JJ
cord-001734-bbeznd3r	318	41	exchange	exchange	NN
cord-001734-bbeznd3r	318	42	of	of	IN
cord-001734-bbeznd3r	318	43	NS2B	NS2B	NNP
cord-001734-bbeznd3r	318	44	between	between	IN
cord-001734-bbeznd3r	318	45	open	open	JJ
cord-001734-bbeznd3r	318	46	and	and	CC
cord-001734-bbeznd3r	318	47	closed	closed	JJ
cord-001734-bbeznd3r	318	48	conformations	conformation	NNS
cord-001734-bbeznd3r	318	49	[	[	-LRB-
cord-001734-bbeznd3r	318	50	8	8	CD
cord-001734-bbeznd3r	318	51	]	]	-RRB-
cord-001734-bbeznd3r	319	1	[	[	-LRB-
cord-001734-bbeznd3r	319	2	9	9	CD
cord-001734-bbeznd3r	319	3	]	]	-RRB-
cord-001734-bbeznd3r	319	4	[	[	-LRB-
cord-001734-bbeznd3r	319	5	10	10	CD
cord-001734-bbeznd3r	319	6	]	]	-RRB-
cord-001734-bbeznd3r	319	7	[	[	-LRB-
cord-001734-bbeznd3r	319	8	11	11	CD
cord-001734-bbeznd3r	319	9	]	]	-RRB-
cord-001734-bbeznd3r	319	10	[	[	-LRB-
cord-001734-bbeznd3r	319	11	12	12	CD
cord-001734-bbeznd3r	319	12	]	]	-RRB-
cord-001734-bbeznd3r	319	13	.	.	.
cord-001734-bbeznd3r	320	1	The	the	DT
cord-001734-bbeznd3r	320	2	correlated	correlated	JJ
cord-001734-bbeznd3r	320	3	motions	motion	NNS
cord-001734-bbeznd3r	320	4	in	in	IN
cord-001734-bbeznd3r	320	5	proteins	protein	NNS
cord-001734-bbeznd3r	320	6	have	have	VBP
cord-001734-bbeznd3r	320	7	been	be	VBN
cord-001734-bbeznd3r	320	8	extensively	extensively	RB
cord-001734-bbeznd3r	320	9	recognized	recognize	VBN
cord-001734-bbeznd3r	320	10	to	to	TO
cord-001734-bbeznd3r	320	11	be	be	VB
cord-001734-bbeznd3r	320	12	critical	critical	JJ
cord-001734-bbeznd3r	320	13	for	for	IN
cord-001734-bbeznd3r	320	14	their	-PRON-	PRP$
cord-001734-bbeznd3r	320	15	diverse	diverse	JJ
cord-001734-bbeznd3r	320	16	functions	function	NNS
cord-001734-bbeznd3r	320	17	[	[	-LRB-
cord-001734-bbeznd3r	320	18	20	20	CD
cord-001734-bbeznd3r	320	19	,	,	,
cord-001734-bbeznd3r	320	20	21	21	CD
cord-001734-bbeznd3r	320	21	,	,	,
cord-001734-bbeznd3r	320	22	30	30	CD
cord-001734-bbeznd3r	320	23	,	,	,
cord-001734-bbeznd3r	320	24	53	53	CD
cord-001734-bbeznd3r	320	25	]	]	-RRB-
cord-001734-bbeznd3r	320	26	.	.	.
cord-001734-bbeznd3r	321	1	In	in	IN
cord-001734-bbeznd3r	321	2	particular	particular	JJ
cord-001734-bbeznd3r	321	3	,	,	,
cord-001734-bbeznd3r	321	4	we	-PRON-	PRP
cord-001734-bbeznd3r	321	5	have	have	VBP
cord-001734-bbeznd3r	321	6	recently	recently	RB
cord-001734-bbeznd3r	321	7	revealed	reveal	VBN
cord-001734-bbeznd3r	321	8	that	that	IN
cord-001734-bbeznd3r	321	9	a	a	DT
cord-001734-bbeznd3r	321	10	global	global	JJ
cord-001734-bbeznd3r	321	11	correlated	correlated	JJ
cord-001734-bbeznd3r	321	12	motion	motion	NN
cord-001734-bbeznd3r	321	13	network	network	NN
cord-001734-bbeznd3r	321	14	was	be	VBD
cord-001734-bbeznd3r	321	15	essential	essential	JJ
cord-001734-bbeznd3r	321	16	for	for	IN
cord-001734-bbeznd3r	321	17	the	the	DT
cord-001734-bbeznd3r	321	18	catalysis	catalysis	NN
cord-001734-bbeznd3r	321	19	of	of	IN
cord-001734-bbeznd3r	321	20	the	the	DT
cord-001734-bbeznd3r	321	21	SARS	SARS	NNP
cord-001734-bbeznd3r	321	22	3C	3C	NNP
cord-001734-bbeznd3r	321	23	-	-	HYPH
cord-001734-bbeznd3r	321	24	like	like	JJ
cord-001734-bbeznd3r	321	25	protease	protease	NN
cord-001734-bbeznd3r	321	26	[	[	-LRB-
cord-001734-bbeznd3r	321	27	20	20	CD
cord-001734-bbeznd3r	321	28	,	,	,
cord-001734-bbeznd3r	321	29	21	21	CD
cord-001734-bbeznd3r	321	30	]	]	-RRB-
cord-001734-bbeznd3r	321	31	,	,	,
cord-001734-bbeznd3r	321	32	which	which	WDT
cord-001734-bbeznd3r	321	33	also	also	RB
cord-001734-bbeznd3r	321	34	utilizes	utilize	VBZ
cord-001734-bbeznd3r	321	35	the	the	DT
cord-001734-bbeznd3r	321	36	chymotrypsin	chymotrypsin	NNP
cord-001734-bbeznd3r	321	37	fold	fold	VB
cord-001734-bbeznd3r	321	38	to	to	TO
cord-001734-bbeznd3r	321	39	harbour	harbour	VB
cord-001734-bbeznd3r	321	40	its	-PRON-	PRP$
cord-001734-bbeznd3r	321	41	catalytic	catalytic	JJ
cord-001734-bbeznd3r	321	42	machinery	machinery	NN
cord-001734-bbeznd3r	321	43	.	.	.
cord-001734-bbeznd3r	322	1	More	more	RBR
cord-001734-bbeznd3r	322	2	specifically	specifically	RB
cord-001734-bbeznd3r	322	3	,	,	,
cord-001734-bbeznd3r	322	4	without	without	IN
cord-001734-bbeznd3r	322	5	altering	alter	VBG
cord-001734-bbeznd3r	322	6	the	the	DT
cord-001734-bbeznd3r	322	7	three	three	CD
cord-001734-bbeznd3r	322	8	-	-	HYPH
cord-001734-bbeznd3r	322	9	dimensional	dimensional	JJ
cord-001734-bbeznd3r	322	10	structure	structure	NN
cord-001734-bbeznd3r	322	11	of	of	IN
cord-001734-bbeznd3r	322	12	the	the	DT
cord-001734-bbeznd3r	322	13	enzyme	enzyme	NN
cord-001734-bbeznd3r	322	14	,	,	,
cord-001734-bbeznd3r	322	15	the	the	DT
cord-001734-bbeznd3r	322	16	N214A	N214A	NNP
cord-001734-bbeznd3r	322	17	mutation	mutation	NN
cord-001734-bbeznd3r	322	18	on	on	IN
cord-001734-bbeznd3r	322	19	the	the	DT
cord-001734-bbeznd3r	322	20	extra	extra	JJ
cord-001734-bbeznd3r	322	21	domain	domain	NN
cord-001734-bbeznd3r	322	22	is	be	VBZ
cord-001734-bbeznd3r	322	23	sufficient	sufficient	JJ
cord-001734-bbeznd3r	322	24	to	to	TO
cord-001734-bbeznd3r	322	25	inactivate	inactivate	VB
cord-001734-bbeznd3r	322	26	the	the	DT
cord-001734-bbeznd3r	322	27	catalytic	catalytic	JJ
cord-001734-bbeznd3r	322	28	machinery	machinery	NN
cord-001734-bbeznd3r	322	29	by	by	IN
cord-001734-bbeznd3r	322	30	globally	globally	RB
cord-001734-bbeznd3r	322	31	decoupling	decouple	VBG
cord-001734-bbeznd3r	322	32	the	the	DT
cord-001734-bbeznd3r	322	33	correlation	correlation	NN
cord-001734-bbeznd3r	322	34	network	network	NN
cord-001734-bbeznd3r	322	35	,	,	,
cord-001734-bbeznd3r	322	36	while	while	IN
cord-001734-bbeznd3r	322	37	the	the	DT
cord-001734-bbeznd3r	322	38	STI	STI	NNP
cord-001734-bbeznd3r	322	39	/	/	SYM
cord-001734-bbeznd3r	322	40	A	A	NNP
cord-001734-bbeznd3r	322	41	mutations	mutation	NNS
cord-001734-bbeznd3r	322	42	also	also	RB
cord-001734-bbeznd3r	322	43	on	on	IN
cord-001734-bbeznd3r	322	44	the	the	DT
cord-001734-bbeznd3r	322	45	extra	extra	JJ
cord-001734-bbeznd3r	322	46	domain	domain	NN
cord-001734-bbeznd3r	322	47	enhance	enhance	VBP
cord-001734-bbeznd3r	322	48	the	the	DT
cord-001734-bbeznd3r	322	49	catalytic	catalytic	JJ
cord-001734-bbeznd3r	322	50	machinery	machinery	NN
cord-001734-bbeznd3r	322	51	by	by	IN
cord-001734-bbeznd3r	322	52	altering	alter	VBG
cord-001734-bbeznd3r	322	53	the	the	DT
cord-001734-bbeznd3r	322	54	correlation	correlation	NN
cord-001734-bbeznd3r	322	55	network	network	NN
cord-001734-bbeznd3r	322	56	pattern	pattern	NN
cord-001734-bbeznd3r	322	57	[	[	-LRB-
cord-001734-bbeznd3r	322	58	20	20	CD
cord-001734-bbeznd3r	322	59	,	,	,
cord-001734-bbeznd3r	322	60	21	21	CD
cord-001734-bbeznd3r	322	61	]	]	-RRB-
cord-001734-bbeznd3r	322	62	.	.	.
cord-001734-bbeznd3r	323	1	In	in	IN
cord-001734-bbeznd3r	323	2	the	the	DT
cord-001734-bbeznd3r	323	3	present	present	JJ
cord-001734-bbeznd3r	323	4	study	study	NN
cord-001734-bbeznd3r	323	5	,	,	,
cord-001734-bbeznd3r	323	6	a	a	DT
cord-001734-bbeznd3r	323	7	similar	similar	JJ
cord-001734-bbeznd3r	323	8	scenario	scenario	NN
cord-001734-bbeznd3r	323	9	has	have	VBZ
cord-001734-bbeznd3r	323	10	been	be	VBN
cord-001734-bbeznd3r	323	11	observed	observe	VBN
cord-001734-bbeznd3r	323	12	for	for	IN
cord-001734-bbeznd3r	323	13	the	the	DT
cord-001734-bbeznd3r	323	14	dengue	dengue	NN
cord-001734-bbeznd3r	323	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	323	16	-	-	HYPH
cord-001734-bbeznd3r	323	17	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	323	18	complex	complex	NN
cord-001734-bbeznd3r	323	19	.	.	.
cord-001734-bbeznd3r	324	1	A	a	DT
cord-001734-bbeznd3r	324	2	global	global	JJ
cord-001734-bbeznd3r	324	3	correlation	correlation	NN
cord-001734-bbeznd3r	324	4	network	network	NN
cord-001734-bbeznd3r	324	5	does	do	VBZ
cord-001734-bbeznd3r	324	6	exist	exist	VB
cord-001734-bbeznd3r	324	7	in	in	IN
cord-001734-bbeznd3r	324	8	the	the	DT
cord-001734-bbeznd3r	324	9	NS2B	NS2B	NNP
cord-001734-bbeznd3r	324	10	-	-	:
cord-001734-bbeznd3r	324	11	NS3	ns3	RB
cord-001734-bbeznd3r	324	12	complex	complex	JJ
cord-001734-bbeznd3r	324	13	.	.	.
cord-001734-bbeznd3r	325	1	Most	most	RBS
cord-001734-bbeznd3r	325	2	intriguingly	intriguingly	RB
cord-001734-bbeznd3r	325	3	,	,	,
cord-001734-bbeznd3r	325	4	this	this	DT
cord-001734-bbeznd3r	325	5	global	global	JJ
cord-001734-bbeznd3r	325	6	correlation	correlation	NN
cord-001734-bbeznd3r	325	7	network	network	NN
cord-001734-bbeznd3r	325	8	is	be	VBZ
cord-001734-bbeznd3r	325	9	mostly	mostly	RB
cord-001734-bbeznd3r	325	10	coordinated	coordinate	VBN
cord-001734-bbeznd3r	325	11	by	by	IN
cord-001734-bbeznd3r	325	12	the	the	DT
cord-001734-bbeznd3r	325	13	NS2B	NS2B	NNP
cord-001734-bbeznd3r	325	14	residues	residue	NNS
cord-001734-bbeznd3r	325	15	which	which	WDT
cord-001734-bbeznd3r	325	16	have	have	VBP
cord-001734-bbeznd3r	325	17	very	very	RB
cord-001734-bbeznd3r	325	18	high	high	JJ
cord-001734-bbeznd3r	325	19	structural	structural	JJ
cord-001734-bbeznd3r	325	20	dynamics	dynamic	NNS
cord-001734-bbeznd3r	325	21	.	.	.
cord-001734-bbeznd3r	326	1	As	as	IN
cord-001734-bbeznd3r	326	2	such	such	JJ
cord-001734-bbeznd3r	326	3	,	,	,
cord-001734-bbeznd3r	326	4	the	the	DT
cord-001734-bbeznd3r	326	5	MD	MD	NNP
cord-001734-bbeznd3r	326	6	results	result	VBZ
cord-001734-bbeznd3r	326	7	not	not	RB
cord-001734-bbeznd3r	326	8	only	only	RB
cord-001734-bbeznd3r	326	9	rationalizes	rationalize	VBZ
cord-001734-bbeznd3r	326	10	the	the	DT
cord-001734-bbeznd3r	326	11	central	central	JJ
cord-001734-bbeznd3r	326	12	role	role	NN
cord-001734-bbeznd3r	326	13	of	of	IN
cord-001734-bbeznd3r	326	14	the	the	DT
cord-001734-bbeznd3r	326	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	326	16	cofactor	cofactor	NN
cord-001734-bbeznd3r	326	17	in	in	IN
cord-001734-bbeznd3r	326	18	maintaining	maintain	VBG
cord-001734-bbeznd3r	326	19	the	the	DT
cord-001734-bbeznd3r	326	20	dynamic	dynamic	JJ
cord-001734-bbeznd3r	326	21	stability	stability	NN
cord-001734-bbeznd3r	326	22	of	of	IN
cord-001734-bbeznd3r	326	23	the	the	DT
cord-001734-bbeznd3r	326	24	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	326	25	domain	domain	NN
cord-001734-bbeznd3r	326	26	,	,	,
cord-001734-bbeznd3r	326	27	but	but	CC
cord-001734-bbeznd3r	326	28	further	further	RB
cord-001734-bbeznd3r	326	29	implies	imply	VBZ
cord-001734-bbeznd3r	326	30	that	that	IN
cord-001734-bbeznd3r	326	31	a	a	DT
cord-001734-bbeznd3r	326	32	slight	slight	JJ
cord-001734-bbeznd3r	326	33	perturbation	perturbation	NN
cord-001734-bbeznd3r	326	34	of	of	IN
cord-001734-bbeznd3r	326	35	the	the	DT
cord-001734-bbeznd3r	326	36	NS2B	NS2B	NNP
cord-001734-bbeznd3r	326	37	-	-	HYPH
cord-001734-bbeznd3r	326	38	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	326	39	interface	interface	NN
cord-001734-bbeznd3r	326	40	may	may	MD
cord-001734-bbeznd3r	326	41	be	be	VB
cord-001734-bbeznd3r	326	42	sufficient	sufficient	JJ
cord-001734-bbeznd3r	326	43	to	to	TO
cord-001734-bbeznd3r	326	44	decouple	decouple	VB
cord-001734-bbeznd3r	326	45	the	the	DT
cord-001734-bbeznd3r	326	46	correlation	correlation	NN
cord-001734-bbeznd3r	326	47	network	network	NN
cord-001734-bbeznd3r	326	48	to	to	TO
cord-001734-bbeznd3r	326	49	inactive	inactive	VB
cord-001734-bbeznd3r	326	50	the	the	DT
cord-001734-bbeznd3r	326	51	catalytic	catalytic	JJ
cord-001734-bbeznd3r	326	52	machinery	machinery	NN
cord-001734-bbeznd3r	326	53	of	of	IN
cord-001734-bbeznd3r	326	54	the	the	DT
cord-001734-bbeznd3r	326	55	dengue	dengue	NN
cord-001734-bbeznd3r	326	56	NS2B	NS2B	NNP
cord-001734-bbeznd3r	326	57	-	-	HYPH
cord-001734-bbeznd3r	326	58	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	326	59	protease	protease	NN
cord-001734-bbeznd3r	326	60	,	,	,
cord-001734-bbeznd3r	326	61	as	as	IN
cord-001734-bbeznd3r	326	62	we	-PRON-	PRP
cord-001734-bbeznd3r	326	63	found	find	VBD
cord-001734-bbeznd3r	326	64	on	on	IN
cord-001734-bbeznd3r	326	65	the	the	DT
cord-001734-bbeznd3r	326	66	N214A	N214A	NNP
cord-001734-bbeznd3r	326	67	mutation	mutation	NN
cord-001734-bbeznd3r	326	68	of	of	IN
cord-001734-bbeznd3r	326	69	the	the	DT
cord-001734-bbeznd3r	326	70	SARS	SARS	NNP
cord-001734-bbeznd3r	326	71	3Clike	3clike	IN
cord-001734-bbeznd3r	326	72	protease	protease	NN
cord-001734-bbeznd3r	326	73	[	[	-LRB-
cord-001734-bbeznd3r	326	74	20	20	CD
cord-001734-bbeznd3r	326	75	,	,	,
cord-001734-bbeznd3r	326	76	21	21	CD
cord-001734-bbeznd3r	326	77	]	]	-RRB-
cord-001734-bbeznd3r	326	78	.	.	.
cord-001734-bbeznd3r	327	1	Indeed	indeed	RB
cord-001734-bbeznd3r	327	2	,	,	,
cord-001734-bbeznd3r	327	3	by	by	IN
cord-001734-bbeznd3r	327	4	deleting	delete	VBG
cord-001734-bbeznd3r	327	5	the	the	DT
cord-001734-bbeznd3r	327	6	NS2B	NS2B	NNP
cord-001734-bbeznd3r	327	7	residues	residue	NNS
cord-001734-bbeznd3r	327	8	highly	highly	RB
cord-001734-bbeznd3r	327	9	flexible	flexible	JJ
cord-001734-bbeznd3r	327	10	in	in	IN
cord-001734-bbeznd3r	327	11	MD	MD	NNP
cord-001734-bbeznd3r	327	12	simulations	simulation	NNS
cord-001734-bbeznd3r	327	13	,	,	,
cord-001734-bbeznd3r	327	14	we	-PRON-	PRP
cord-001734-bbeznd3r	327	15	obtained	obtain	VBD
cord-001734-bbeznd3r	327	16	a	a	DT
cord-001734-bbeznd3r	327	17	truncated	truncated	JJ
cord-001734-bbeznd3r	327	18	NS2B	NS2B	NNS
cord-001734-bbeznd3r	327	19	(	(	-LRB-
cord-001734-bbeznd3r	327	20	48	48	CD
cord-001734-bbeznd3r	327	21	-	-	SYM
cord-001734-bbeznd3r	327	22	100;Δ77	100;δ77	CD
cord-001734-bbeznd3r	327	23	-	-	SYM
cord-001734-bbeznd3r	327	24	84	84	CD
cord-001734-bbeznd3r	327	25	)	)	-RRB-
cord-001734-bbeznd3r	327	26	,	,	,
cord-001734-bbeznd3r	327	27	which	which	WDT
cord-001734-bbeznd3r	327	28	is	be	VBZ
cord-001734-bbeznd3r	327	29	able	able	JJ
cord-001734-bbeznd3r	327	30	to	to	TO
cord-001734-bbeznd3r	327	31	trap	trap	VB
cord-001734-bbeznd3r	327	32	the	the	DT
cord-001734-bbeznd3r	327	33	NS2B	NS2B	NNP
cord-001734-bbeznd3r	327	34	-	-	HYPH
cord-001734-bbeznd3r	327	35	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	327	36	complex	complex	NN
cord-001734-bbeznd3r	327	37	in	in	IN
cord-001734-bbeznd3r	327	38	a	a	DT
cord-001734-bbeznd3r	327	39	catalytically	catalytically	RB
cord-001734-bbeznd3r	327	40	-	-	HYPH
cord-001734-bbeznd3r	327	41	impotent	impotent	JJ
cord-001734-bbeznd3r	327	42	state	state	NN
cord-001734-bbeznd3r	327	43	with	with	IN
cord-001734-bbeznd3r	327	44	significant	significant	JJ
cord-001734-bbeznd3r	327	45	μs	μs	NNP
cord-001734-bbeznd3r	327	46	-	-	HYPH
cord-001734-bbeznd3r	327	47	ms	ms	NNP
cord-001734-bbeznd3r	327	48	dynamics	dynamic	NNS
cord-001734-bbeznd3r	327	49	.	.	.
cord-001734-bbeznd3r	328	1	In	in	IN
cord-001734-bbeznd3r	328	2	the	the	DT
cord-001734-bbeznd3r	328	3	further	further	JJ
cord-001734-bbeznd3r	328	4	,	,	,
cord-001734-bbeznd3r	328	5	it	-PRON-	PRP
cord-001734-bbeznd3r	328	6	would	would	MD
cord-001734-bbeznd3r	328	7	be	be	VB
cord-001734-bbeznd3r	328	8	of	of	IN
cord-001734-bbeznd3r	328	9	significant	significant	JJ
cord-001734-bbeznd3r	328	10	interest	interest	NN
cord-001734-bbeznd3r	328	11	to	to	TO
cord-001734-bbeznd3r	328	12	test	test	VB
cord-001734-bbeznd3r	328	13	whether	whether	IN
cord-001734-bbeznd3r	328	14	this	this	DT
cord-001734-bbeznd3r	328	15	truncated	truncated	JJ
cord-001734-bbeznd3r	328	16	NS2B	NS2B	NNP
cord-001734-bbeznd3r	328	17	can	can	MD
cord-001734-bbeznd3r	328	18	act	act	VB
cord-001734-bbeznd3r	328	19	as	as	IN
cord-001734-bbeznd3r	328	20	a	a	DT
cord-001734-bbeznd3r	328	21	specific	specific	JJ
cord-001734-bbeznd3r	328	22	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	328	23	of	of	IN
cord-001734-bbeznd3r	328	24	the	the	DT
cord-001734-bbeznd3r	328	25	dengue	dengue	NN
cord-001734-bbeznd3r	328	26	protease	protease	NN
cord-001734-bbeznd3r	328	27	in	in	IN
cord-001734-bbeznd3r	328	28	vivo	vivo	NNP
cord-001734-bbeznd3r	328	29	.	.	.
cord-001734-bbeznd3r	329	1	Despite	despite	IN
cord-001734-bbeznd3r	329	2	the	the	DT
cord-001734-bbeznd3r	329	3	success	success	NN
cord-001734-bbeznd3r	329	4	in	in	IN
cord-001734-bbeznd3r	329	5	treating	treat	VBG
cord-001734-bbeznd3r	329	6	viral	viral	JJ
cord-001734-bbeznd3r	329	7	infections	infection	NNS
cord-001734-bbeznd3r	329	8	with	with	IN
cord-001734-bbeznd3r	329	9	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	329	10	to	to	TO
cord-001734-bbeznd3r	329	11	target	target	VB
cord-001734-bbeznd3r	329	12	the	the	DT
cord-001734-bbeznd3r	329	13	active	active	JJ
cord-001734-bbeznd3r	329	14	sites	site	NNS
cord-001734-bbeznd3r	329	15	of	of	IN
cord-001734-bbeznd3r	329	16	HIV	HIV	NNP
cord-001734-bbeznd3r	329	17	and	and	CC
cord-001734-bbeznd3r	329	18	HCV	HCV	NNP
cord-001734-bbeznd3r	329	19	proteases	protease	NNS
cord-001734-bbeznd3r	329	20	[	[	-LRB-
cord-001734-bbeznd3r	329	21	41	41	CD
cord-001734-bbeznd3r	329	22	]	]	-RRB-
cord-001734-bbeznd3r	329	23	[	[	-LRB-
cord-001734-bbeznd3r	329	24	42	42	CD
cord-001734-bbeznd3r	329	25	]	]	-RRB-
cord-001734-bbeznd3r	329	26	[	[	-LRB-
cord-001734-bbeznd3r	329	27	43	43	CD
cord-001734-bbeznd3r	329	28	]	]	-RRB-
cord-001734-bbeznd3r	329	29	,	,	,
cord-001734-bbeznd3r	329	30	many	many	JJ
cord-001734-bbeznd3r	329	31	challenges	challenge	NNS
cord-001734-bbeznd3r	329	32	/	/	SYM
cord-001734-bbeznd3r	329	33	difficulties	difficulty	NNS
cord-001734-bbeznd3r	329	34	still	still	RB
cord-001734-bbeznd3r	329	35	remain	remain	VBP
cord-001734-bbeznd3r	329	36	for	for	IN
cord-001734-bbeznd3r	329	37	this	this	DT
cord-001734-bbeznd3r	329	38	approach	approach	NN
cord-001734-bbeznd3r	329	39	.	.	.
cord-001734-bbeznd3r	330	1	For	for	IN
cord-001734-bbeznd3r	330	2	example	example	NN
cord-001734-bbeznd3r	330	3	,	,	,
cord-001734-bbeznd3r	330	4	the	the	DT
cord-001734-bbeznd3r	330	5	structural	structural	JJ
cord-001734-bbeznd3r	330	6	architecture	architecture	NN
cord-001734-bbeznd3r	330	7	and	and	CC
cord-001734-bbeznd3r	330	8	catalytic	catalytic	JJ
cord-001734-bbeznd3r	330	9	mechanism	mechanism	NN
cord-001734-bbeznd3r	330	10	of	of	IN
cord-001734-bbeznd3r	330	11	viral	viral	JJ
cord-001734-bbeznd3r	330	12	proteases	protease	NNS
cord-001734-bbeznd3r	330	13	are	be	VBP
cord-001734-bbeznd3r	330	14	also	also	RB
cord-001734-bbeznd3r	330	15	largely	largely	RB
cord-001734-bbeznd3r	330	16	shared	share	VBN
cord-001734-bbeznd3r	330	17	by	by	IN
cord-001734-bbeznd3r	330	18	many	many	JJ
cord-001734-bbeznd3r	330	19	human	human	JJ
cord-001734-bbeznd3r	330	20	proteases	protease	NNS
cord-001734-bbeznd3r	330	21	.	.	.
cord-001734-bbeznd3r	331	1	This	this	DT
cord-001734-bbeznd3r	331	2	makes	make	VBZ
cord-001734-bbeznd3r	331	3	it	-PRON-	PRP
cord-001734-bbeznd3r	331	4	extremely	extremely	RB
cord-001734-bbeznd3r	331	5	challenging	challenging	JJ
cord-001734-bbeznd3r	331	6	to	to	TO
cord-001734-bbeznd3r	331	7	design	design	NN
cord-001734-bbeznd3r	331	8	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	331	9	which	which	WDT
cord-001734-bbeznd3r	331	10	only	only	RB
cord-001734-bbeznd3r	331	11	specifically	specifically	RB
cord-001734-bbeznd3r	331	12	bind	bind	VBP
cord-001734-bbeznd3r	331	13	to	to	IN
cord-001734-bbeznd3r	331	14	viral	viral	JJ
cord-001734-bbeznd3r	331	15	proteases	protease	NNS
cord-001734-bbeznd3r	331	16	but	but	CC
cord-001734-bbeznd3r	331	17	not	not	RB
cord-001734-bbeznd3r	331	18	to	to	IN
cord-001734-bbeznd3r	331	19	human	human	JJ
cord-001734-bbeznd3r	331	20	ones	one	NNS
cord-001734-bbeznd3r	331	21	.	.	.
cord-001734-bbeznd3r	332	1	Moreover	moreover	RB
cord-001734-bbeznd3r	332	2	,	,	,
cord-001734-bbeznd3r	332	3	there	there	EX
cord-001734-bbeznd3r	332	4	is	be	VBZ
cord-001734-bbeznd3r	332	5	an	an	DT
cord-001734-bbeznd3r	332	6	addition	addition	NN
cord-001734-bbeznd3r	332	7	challenge	challenge	NN
cord-001734-bbeznd3r	332	8	associated	associate	VBN
cord-001734-bbeznd3r	332	9	with	with	IN
cord-001734-bbeznd3r	332	10	the	the	DT
cord-001734-bbeznd3r	332	11	dengue	dengue	NN
cord-001734-bbeznd3r	332	12	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	332	13	protease	protease	NN
cord-001734-bbeznd3r	332	14	.	.	.
cord-001734-bbeznd3r	333	1	It	-PRON-	PRP
cord-001734-bbeznd3r	333	2	has	have	VBZ
cord-001734-bbeznd3r	333	3	been	be	VBN
cord-001734-bbeznd3r	333	4	proposed	propose	VBN
cord-001734-bbeznd3r	333	5	that	that	IN
cord-001734-bbeznd3r	333	6	the	the	DT
cord-001734-bbeznd3r	333	7	flat	flat	JJ
cord-001734-bbeznd3r	333	8	and	and	CC
cord-001734-bbeznd3r	333	9	charged	charged	JJ
cord-001734-bbeznd3r	333	10	nature	nature	NN
cord-001734-bbeznd3r	333	11	of	of	IN
cord-001734-bbeznd3r	333	12	its	-PRON-	PRP$
cord-001734-bbeznd3r	333	13	active	active	JJ
cord-001734-bbeznd3r	333	14	site	site	NN
cord-001734-bbeznd3r	333	15	may	may	MD
cord-001734-bbeznd3r	333	16	at	at	IN
cord-001734-bbeznd3r	333	17	least	least	JJS
cord-001734-bbeznd3r	333	18	partly	partly	RB
cord-001734-bbeznd3r	333	19	contribute	contribute	VB
cord-001734-bbeznd3r	333	20	to	to	IN
cord-001734-bbeznd3r	333	21	the	the	DT
cord-001734-bbeznd3r	333	22	current	current	JJ
cord-001734-bbeznd3r	333	23	failure	failure	NN
cord-001734-bbeznd3r	333	24	in	in	IN
cord-001734-bbeznd3r	333	25	developing	develop	VBG
cord-001734-bbeznd3r	333	26	effective	effective	JJ
cord-001734-bbeznd3r	333	27	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	333	28	[	[	-LRB-
cord-001734-bbeznd3r	333	29	7	7	CD
cord-001734-bbeznd3r	333	30	,	,	,
cord-001734-bbeznd3r	333	31	45	45	CD
cord-001734-bbeznd3r	333	32	]	]	-RRB-
cord-001734-bbeznd3r	333	33	.	.	.
cord-001734-bbeznd3r	334	1	To	to	TO
cord-001734-bbeznd3r	334	2	overcome	overcome	VB
cord-001734-bbeznd3r	334	3	these	these	DT
cord-001734-bbeznd3r	334	4	difficulties	difficulty	NNS
cord-001734-bbeznd3r	334	5	,	,	,
cord-001734-bbeznd3r	334	6	alternative	alternative	JJ
cord-001734-bbeznd3r	334	7	strategies	strategy	NNS
cord-001734-bbeznd3r	334	8	are	be	VBP
cord-001734-bbeznd3r	334	9	requested	request	VBN
cord-001734-bbeznd3r	334	10	to	to	IN
cord-001734-bbeznd3r	334	11	targets	target	NNS
cord-001734-bbeznd3r	334	12	sites	site	NNS
cord-001734-bbeznd3r	334	13	other	other	JJ
cord-001734-bbeznd3r	334	14	than	than	IN
cord-001734-bbeznd3r	334	15	the	the	DT
cord-001734-bbeznd3r	334	16	active	active	JJ
cord-001734-bbeznd3r	334	17	sites	site	NNS
cord-001734-bbeznd3r	334	18	of	of	IN
cord-001734-bbeznd3r	334	19	the	the	DT
cord-001734-bbeznd3r	334	20	viral	viral	JJ
cord-001734-bbeznd3r	334	21	proteases	protease	NNS
cord-001734-bbeznd3r	334	22	,	,	,
cord-001734-bbeznd3r	334	23	such	such	JJ
cord-001734-bbeznd3r	334	24	as	as	IN
cord-001734-bbeznd3r	334	25	to	to	TO
cord-001734-bbeznd3r	334	26	inhibit	inhibit	VB
cord-001734-bbeznd3r	334	27	the	the	DT
cord-001734-bbeznd3r	334	28	dimerization	dimerization	NN
cord-001734-bbeznd3r	334	29	required	require	VBN
cord-001734-bbeznd3r	334	30	for	for	IN
cord-001734-bbeznd3r	334	31	activity	activity	NN
cord-001734-bbeznd3r	334	32	[	[	-LRB-
cord-001734-bbeznd3r	334	33	46	46	CD
cord-001734-bbeznd3r	334	34	]	]	-RRB-
cord-001734-bbeznd3r	334	35	,	,	,
cord-001734-bbeznd3r	334	36	to	to	TO
cord-001734-bbeznd3r	334	37	trigger	trigger	VB
cord-001734-bbeznd3r	334	38	allosteric	allosteric	JJ
cord-001734-bbeznd3r	334	39	inhibition	inhibition	NN
cord-001734-bbeznd3r	334	40	[	[	-LRB-
cord-001734-bbeznd3r	334	41	45	45	CD
cord-001734-bbeznd3r	334	42	]	]	-RRB-
cord-001734-bbeznd3r	334	43	,	,	,
cord-001734-bbeznd3r	334	44	or	or	CC
cord-001734-bbeznd3r	334	45	even	even	RB
cord-001734-bbeznd3r	334	46	to	to	TO
cord-001734-bbeznd3r	334	47	block	block	VB
cord-001734-bbeznd3r	334	48	the	the	DT
cord-001734-bbeznd3r	334	49	folding	folding	NN
cord-001734-bbeznd3r	334	50	of	of	IN
cord-001734-bbeznd3r	334	51	the	the	DT
cord-001734-bbeznd3r	334	52	protease	protease	NN
cord-001734-bbeznd3r	334	53	[	[	-LRB-
cord-001734-bbeznd3r	334	54	54	54	CD
cord-001734-bbeznd3r	334	55	]	]	-RRB-
cord-001734-bbeznd3r	334	56	.	.	.
cord-001734-bbeznd3r	335	1	In	in	IN
cord-001734-bbeznd3r	335	2	this	this	DT
cord-001734-bbeznd3r	335	3	regard	regard	NN
cord-001734-bbeznd3r	335	4	,	,	,
cord-001734-bbeznd3r	335	5	our	-PRON-	PRP$
cord-001734-bbeznd3r	335	6	present	present	JJ
cord-001734-bbeznd3r	335	7	study	study	NN
cord-001734-bbeznd3r	335	8	successfully	successfully	RB
cord-001734-bbeznd3r	335	9	implies	imply	VBZ
cord-001734-bbeznd3r	335	10	potential	potential	JJ
cord-001734-bbeznd3r	335	11	strategies	strategy	NNS
cord-001734-bbeznd3r	335	12	to	to	TO
cord-001734-bbeznd3r	335	13	perturb	perturb	VB
cord-001734-bbeznd3r	335	14	the	the	DT
cord-001734-bbeznd3r	335	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	335	16	-	-	HYPH
cord-001734-bbeznd3r	335	17	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	335	18	interface	interface	NN
cord-001734-bbeznd3r	335	19	for	for	IN
cord-001734-bbeznd3r	335	20	future	future	JJ
cord-001734-bbeznd3r	335	21	developing	develop	VBG
cord-001734-bbeznd3r	335	22	effective	effective	JJ
cord-001734-bbeznd3r	335	23	and	and	CC
cord-001734-bbeznd3r	335	24	specific	specific	JJ
cord-001734-bbeznd3r	335	25	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	335	26	for	for	IN
cord-001734-bbeznd3r	335	27	the	the	DT
cord-001734-bbeznd3r	335	28	dengue	dengue	NN
cord-001734-bbeznd3r	335	29	protease	protease	NN
cord-001734-bbeznd3r	335	30	.	.	.
cord-001734-bbeznd3r	336	1	More	more	RBR
cord-001734-bbeznd3r	336	2	specifically	specifically	RB
cord-001734-bbeznd3r	336	3	,	,	,
cord-001734-bbeznd3r	336	4	inhibitory	inhibitory	JJ
cord-001734-bbeznd3r	336	5	molecules	molecule	NNS
cord-001734-bbeznd3r	336	6	might	may	MD
cord-001734-bbeznd3r	336	7	be	be	VB
cord-001734-bbeznd3r	336	8	developed	develop	VBN
cord-001734-bbeznd3r	336	9	to	to	IN
cord-001734-bbeznd3r	336	10	:	:	:
cord-001734-bbeznd3r	336	11	1	1	LS
cord-001734-bbeznd3r	336	12	)	)	-RRB-
cord-001734-bbeznd3r	336	13	trap	trap	VB
cord-001734-bbeznd3r	336	14	the	the	DT
cord-001734-bbeznd3r	336	15	NS2B	NS2B	NNP
cord-001734-bbeznd3r	336	16	-	-	HYPH
cord-001734-bbeznd3r	336	17	mediated	mediate	VBN
cord-001734-bbeznd3r	336	18	folding	folding	NN
cord-001734-bbeznd3r	336	19	into	into	IN
cord-001734-bbeznd3r	336	20	an	an	DT
cord-001734-bbeznd3r	336	21	inactive	inactive	JJ
cord-001734-bbeznd3r	336	22	intermediate	intermediate	JJ
cord-001734-bbeznd3r	336	23	as	as	IN
cord-001734-bbeznd3r	336	24	exemplified	exemplify	VBN
cord-001734-bbeznd3r	336	25	by	by	IN
cord-001734-bbeznd3r	336	26	the	the	DT
cord-001734-bbeznd3r	336	27	truncated	truncated	JJ
cord-001734-bbeznd3r	336	28	NS2B	NS2B	NNP
cord-001734-bbeznd3r	336	29	;	;	:
cord-001734-bbeznd3r	336	30	and	and	CC
cord-001734-bbeznd3r	336	31	2	2	LS
cord-001734-bbeznd3r	336	32	)	)	-RRB-
cord-001734-bbeznd3r	336	33	decouple	decouple	VBP
cord-001734-bbeznd3r	336	34	the	the	DT
cord-001734-bbeznd3r	336	35	global	global	JJ
cord-001734-bbeznd3r	336	36	correlation	correlation	NN
cord-001734-bbeznd3r	336	37	network	network	NN
cord-001734-bbeznd3r	336	38	of	of	IN
cord-001734-bbeznd3r	336	39	the	the	DT
cord-001734-bbeznd3r	336	40	NS2B	NS2B	NNP
cord-001734-bbeznd3r	336	41	-	-	HYPH
cord-001734-bbeznd3r	336	42	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	336	43	complex	complex	NN
cord-001734-bbeznd3r	336	44	.	.	.
cord-001734-bbeznd3r	337	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	337	2	,	,	,
cord-001734-bbeznd3r	337	3	our	-PRON-	PRP$
cord-001734-bbeznd3r	337	4	success	success	NN
cord-001734-bbeznd3r	337	5	in	in	IN
cord-001734-bbeznd3r	337	6	in	in	FW
cord-001734-bbeznd3r	337	7	vitro	vitro	FW
cord-001734-bbeznd3r	337	8	refolding	refolde	VBG
cord-001734-bbeznd3r	337	9	of	of	IN
cord-001734-bbeznd3r	337	10	the	the	DT
cord-001734-bbeznd3r	337	11	active	active	JJ
cord-001734-bbeznd3r	337	12	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	337	13	in	in	IN
cord-001734-bbeznd3r	337	14	complex	complex	NN
cord-001734-bbeznd3r	337	15	with	with	IN
cord-001734-bbeznd3r	337	16	both	both	DT
cord-001734-bbeznd3r	337	17	NS2B	NS2B	NNS
cord-001734-bbeznd3r	337	18	(	(	-LRB-
cord-001734-bbeznd3r	337	19	48	48	CD
cord-001734-bbeznd3r	337	20	-	-	SYM
cord-001734-bbeznd3r	337	21	100	100	CD
cord-001734-bbeznd3r	337	22	)	)	-RRB-
cord-001734-bbeznd3r	337	23	in	in	IN
cord-001734-bbeznd3r	337	24	buffer	buffer	NN
cord-001734-bbeznd3r	337	25	and	and	CC
cord-001734-bbeznd3r	337	26	NS2B	NS2B	NNP
cord-001734-bbeznd3r	337	27	in	in	IN
cord-001734-bbeznd3r	337	28	the	the	DT
cord-001734-bbeznd3r	337	29	micelle	micelle	NN
cord-001734-bbeznd3r	337	30	provides	provide	VBZ
cord-001734-bbeznd3r	337	31	experimental	experimental	JJ
cord-001734-bbeznd3r	337	32	platforms	platform	NNS
cord-001734-bbeznd3r	337	33	for	for	IN
cord-001734-bbeznd3r	337	34	implementing	implement	VBG
cord-001734-bbeznd3r	337	35	the	the	DT
cord-001734-bbeznd3r	337	36	above	above	RB
cord-001734-bbeznd3r	337	37	-	-	HYPH
cord-001734-bbeznd3r	337	38	proposed	propose	VBN
cord-001734-bbeznd3r	337	39	approaches	approach	NNS
cord-001734-bbeznd3r	337	40	of	of	IN
cord-001734-bbeznd3r	337	41	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	337	42	design	design	NN
cord-001734-bbeznd3r	337	43	as	as	RB
cord-001734-bbeznd3r	337	44	well	well	RB
cord-001734-bbeznd3r	337	45	as	as	IN
cord-001734-bbeznd3r	337	46	to	to	TO
cord-001734-bbeznd3r	337	47	decode	decode	VB
cord-001734-bbeznd3r	337	48	the	the	DT
cord-001734-bbeznd3r	337	49	underlying	underlying	JJ
cord-001734-bbeznd3r	337	50	mechanism	mechanism	NN
cord-001734-bbeznd3r	337	51	for	for	IN
cord-001734-bbeznd3r	337	52	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	337	53	obtained	obtain	VBN
cord-001734-bbeznd3r	337	54	by	by	IN
cord-001734-bbeznd3r	337	55	high	high	JJ
cord-001734-bbeznd3r	337	56	through	through	IN
cord-001734-bbeznd3r	337	57	-	-	HYPH
cord-001734-bbeznd3r	337	58	put	put	NN
cord-001734-bbeznd3r	337	59	screening	screening	NN
cord-001734-bbeznd3r	337	60	.	.	.
cord-001734-bbeznd3r	338	1	For	for	IN
cord-001734-bbeznd3r	338	2	example	example	NN
cord-001734-bbeznd3r	338	3	,	,	,
cord-001734-bbeznd3r	338	4	recently	recently	RB
cord-001734-bbeznd3r	338	5	the	the	DT
cord-001734-bbeznd3r	338	6	dengue	dengue	NN
cord-001734-bbeznd3r	338	7	protease	protease	NN
cord-001734-bbeznd3r	338	8	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	338	9	were	be	VBD
cord-001734-bbeznd3r	338	10	identified	identify	VBN
cord-001734-bbeznd3r	338	11	by	by	IN
cord-001734-bbeznd3r	338	12	high	high	JJ
cord-001734-bbeznd3r	338	13	through	through	IN
cord-001734-bbeznd3r	338	14	-	-	HYPH
cord-001734-bbeznd3r	338	15	put	put	NN
cord-001734-bbeznd3r	338	16	screening	screening	NN
cord-001734-bbeznd3r	338	17	,	,	,
cord-001734-bbeznd3r	338	18	which	which	WDT
cord-001734-bbeznd3r	338	19	were	be	VBD
cord-001734-bbeznd3r	338	20	implied	imply	VBN
cord-001734-bbeznd3r	338	21	to	to	TO
cord-001734-bbeznd3r	338	22	target	target	VB
cord-001734-bbeznd3r	338	23	the	the	DT
cord-001734-bbeznd3r	338	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	338	25	-	-	HYPH
cord-001734-bbeznd3r	338	26	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	338	27	interface	interface	NN
cord-001734-bbeznd3r	338	28	by	by	IN
cord-001734-bbeznd3r	338	29	in	in	IN
cord-001734-bbeznd3r	338	30	silico	silico	NN
cord-001734-bbeznd3r	338	31	prediction	prediction	NN
cord-001734-bbeznd3r	338	32	or	or	CC
cord-001734-bbeznd3r	338	33	mutagenesis	mutagenesis	NN
cord-001734-bbeznd3r	338	34	[	[	-LRB-
cord-001734-bbeznd3r	338	35	55	55	CD
cord-001734-bbeznd3r	338	36	,	,	,
cord-001734-bbeznd3r	338	37	56	56	CD
cord-001734-bbeznd3r	338	38	]	]	-RRB-
cord-001734-bbeznd3r	338	39	.	.	.
cord-001734-bbeznd3r	339	1	It	-PRON-	PRP
cord-001734-bbeznd3r	339	2	would	would	MD
cord-001734-bbeznd3r	339	3	be	be	VB
cord-001734-bbeznd3r	339	4	of	of	IN
cord-001734-bbeznd3r	339	5	significant	significant	JJ
cord-001734-bbeznd3r	339	6	interest	interest	NN
cord-001734-bbeznd3r	339	7	to	to	TO
cord-001734-bbeznd3r	339	8	delineate	delineate	VB
cord-001734-bbeznd3r	339	9	how	how	WRB
cord-001734-bbeznd3r	339	10	these	these	DT
cord-001734-bbeznd3r	339	11	molecules	molecule	NNS
cord-001734-bbeznd3r	339	12	achieve	achieve	VBP
cord-001734-bbeznd3r	339	13	the	the	DT
cord-001734-bbeznd3r	339	14	inhibitory	inhibitory	JJ
cord-001734-bbeznd3r	339	15	effect	effect	NN
cord-001734-bbeznd3r	339	16	:	:	:
cord-001734-bbeznd3r	339	17	by	by	IN
cord-001734-bbeznd3r	339	18	trapping	trap	VBG
cord-001734-bbeznd3r	339	19	the	the	DT
cord-001734-bbeznd3r	339	20	folding	folding	NN
cord-001734-bbeznd3r	339	21	or	or	CC
cord-001734-bbeznd3r	339	22	modulating	modulate	VBG
cord-001734-bbeznd3r	339	23	the	the	DT
cord-001734-bbeznd3r	339	24	dynamics	dynamic	NNS
cord-001734-bbeznd3r	339	25	of	of	IN
cord-001734-bbeznd3r	339	26	the	the	DT
cord-001734-bbeznd3r	339	27	protease	protease	NN
cord-001734-bbeznd3r	339	28	complex	complex	NN
cord-001734-bbeznd3r	339	29	,	,	,
cord-001734-bbeznd3r	339	30	if	if	IN
cord-001734-bbeznd3r	339	31	they	-PRON-	PRP
cord-001734-bbeznd3r	339	32	directly	directly	RB
cord-001734-bbeznd3r	339	33	target	target	VBP
cord-001734-bbeznd3r	339	34	the	the	DT
cord-001734-bbeznd3r	339	35	NS2B	NS2B	NNP
cord-001734-bbeznd3r	339	36	-	-	HYPH
cord-001734-bbeznd3r	339	37	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	339	38	interface	interface	NN
cord-001734-bbeznd3r	339	39	.	.	.
cord-001734-bbeznd3r	340	1	In	in	IN
cord-001734-bbeznd3r	340	2	summary	summary	NN
cord-001734-bbeznd3r	340	3	,	,	,
cord-001734-bbeznd3r	340	4	our	-PRON-	PRP$
cord-001734-bbeznd3r	340	5	study	study	NN
cord-001734-bbeznd3r	340	6	decrypted	decrypt	VBD
cord-001734-bbeznd3r	340	7	that	that	IN
cord-001734-bbeznd3r	340	8	the	the	DT
cord-001734-bbeznd3r	340	9	dengue	dengue	NN
cord-001734-bbeznd3r	340	10	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	340	11	domain	domain	NN
cord-001734-bbeznd3r	340	12	is	be	VBZ
cord-001734-bbeznd3r	340	13	the	the	DT
cord-001734-bbeznd3r	340	14	first	first	JJ
cord-001734-bbeznd3r	340	15	intrinsicallydisordered	intrinsicallydisordered	JJ
cord-001734-bbeznd3r	340	16	chymotrypsin	chymotrypsin	NN
cord-001734-bbeznd3r	340	17	-	-	HYPH
cord-001734-bbeznd3r	340	18	like	like	JJ
cord-001734-bbeznd3r	340	19	fold	fold	NN
cord-001734-bbeznd3r	340	20	which	which	WDT
cord-001734-bbeznd3r	340	21	absolutely	absolutely	RB
cord-001734-bbeznd3r	340	22	requests	request	VBZ
cord-001734-bbeznd3r	340	23	the	the	DT
cord-001734-bbeznd3r	340	24	NS2B	NS2B	NNP
cord-001734-bbeznd3r	340	25	cofactor	cofactor	NN
cord-001734-bbeznd3r	340	26	to	to	TO
cord-001734-bbeznd3r	340	27	coordinate	coordinate	VB
cord-001734-bbeznd3r	340	28	the	the	DT
cord-001734-bbeznd3r	340	29	correct	correct	JJ
cord-001734-bbeznd3r	340	30	folding	folding	NN
cord-001734-bbeznd3r	340	31	as	as	RB
cord-001734-bbeznd3r	340	32	well	well	RB
cord-001734-bbeznd3r	340	33	as	as	IN
cord-001734-bbeznd3r	340	34	correlated	correlate	VBN
cord-001734-bbeznd3r	340	35	motions	motion	NNS
cord-001734-bbeznd3r	340	36	of	of	IN
cord-001734-bbeznd3r	340	37	the	the	DT
cord-001734-bbeznd3r	340	38	NS2B	NS2B	NNP
cord-001734-bbeznd3r	340	39	-	-	HYPH
cord-001734-bbeznd3r	340	40	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	340	41	complex	complex	NN
cord-001734-bbeznd3r	340	42	to	to	TO
cord-001734-bbeznd3r	340	43	achieve	achieve	VB
cord-001734-bbeznd3r	340	44	its	-PRON-	PRP$
cord-001734-bbeznd3r	340	45	catalytic	catalytic	JJ
cord-001734-bbeznd3r	340	46	function	function	NN
cord-001734-bbeznd3r	340	47	.	.	.
cord-001734-bbeznd3r	341	1	In	in	IN
cord-001734-bbeznd3r	341	2	light	light	NN
cord-001734-bbeznd3r	341	3	of	of	IN
cord-001734-bbeznd3r	341	4	a	a	DT
cord-001734-bbeznd3r	341	5	recent	recent	JJ
cord-001734-bbeznd3r	341	6	study	study	NN
cord-001734-bbeznd3r	341	7	[	[	-LRB-
cord-001734-bbeznd3r	341	8	47	47	CD
cord-001734-bbeznd3r	341	9	]	]	-RRB-
cord-001734-bbeznd3r	341	10	,	,	,
cord-001734-bbeznd3r	341	11	the	the	DT
cord-001734-bbeznd3r	341	12	disordered	disordered	JJ
cord-001734-bbeznd3r	341	13	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	341	14	is	be	VBZ
cord-001734-bbeznd3r	341	15	needed	need	VBN
cord-001734-bbeznd3r	341	16	for	for	IN
cord-001734-bbeznd3r	341	17	interacting	interact	VBG
cord-001734-bbeznd3r	341	18	with	with	IN
cord-001734-bbeznd3r	341	19	the	the	DT
cord-001734-bbeznd3r	341	20	human	human	JJ
cord-001734-bbeznd3r	341	21	host	host	NN
cord-001734-bbeznd3r	341	22	factor	factor	NN
cord-001734-bbeznd3r	341	23	to	to	TO
cord-001734-bbeznd3r	341	24	initiate	initiate	VB
cord-001734-bbeznd3r	341	25	the	the	DT
cord-001734-bbeznd3r	341	26	membrane	membrane	NN
cord-001734-bbeznd3r	341	27	remodeling	remodeling	NN
cord-001734-bbeznd3r	341	28	.	.	.
cord-001734-bbeznd3r	342	1	Furthermore	furthermore	RB
cord-001734-bbeznd3r	342	2	,	,	,
cord-001734-bbeznd3r	342	3	our	-PRON-	PRP$
cord-001734-bbeznd3r	342	4	results	result	NNS
cord-001734-bbeznd3r	342	5	also	also	RB
cord-001734-bbeznd3r	342	6	imply	imply	VBP
cord-001734-bbeznd3r	342	7	potential	potential	JJ
cord-001734-bbeznd3r	342	8	strategies	strategy	NNS
cord-001734-bbeznd3r	342	9	to	to	TO
cord-001734-bbeznd3r	342	10	manipulate	manipulate	VB
cord-001734-bbeznd3r	342	11	the	the	DT
cord-001734-bbeznd3r	342	12	NS2B	NS2B	NNP
cord-001734-bbeznd3r	342	13	-	-	HYPH
cord-001734-bbeznd3r	342	14	NS3pro	ns3pro	NN
cord-001734-bbeznd3r	342	15	interface	interface	NN
cord-001734-bbeznd3r	342	16	for	for	IN
cord-001734-bbeznd3r	342	17	design	design	NN
cord-001734-bbeznd3r	342	18	of	of	IN
cord-001734-bbeznd3r	342	19	molecules	molecule	NNS
cord-001734-bbeznd3r	342	20	in	in	IN
cord-001734-bbeznd3r	342	21	the	the	DT
cord-001734-bbeznd3r	342	22	future	future	NN
cord-001734-bbeznd3r	342	23	,	,	,
cord-001734-bbeznd3r	342	24	which	which	WDT
cord-001734-bbeznd3r	342	25	may	may	MD
cord-001734-bbeznd3r	342	26	effectively	effectively	RB
cord-001734-bbeznd3r	342	27	and	and	CC
cord-001734-bbeznd3r	342	28	specifically	specifically	RB
cord-001734-bbeznd3r	342	29	inhibit	inhibit	VB
cord-001734-bbeznd3r	342	30	the	the	DT
cord-001734-bbeznd3r	342	31	protease	protease	NN
cord-001734-bbeznd3r	342	32	activity	activity	NN
cord-001734-bbeznd3r	342	33	for	for	IN
cord-001734-bbeznd3r	342	34	treating	treat	VBG
cord-001734-bbeznd3r	342	35	the	the	DT
cord-001734-bbeznd3r	342	36	dengue	dengue	NN
cord-001734-bbeznd3r	342	37	infection	infection	NN
cord-001734-bbeznd3r	342	38	.	.	.
cord-001734-bbeznd3r	342	39	 	 	_SP
cord-001734-bbeznd3r	343	1	Best	good	JJS
cord-001734-bbeznd3r	343	2	practices	practice	NNS
cord-001734-bbeznd3r	343	3	in	in	IN
cord-001734-bbeznd3r	343	4	dengue	dengue	NN
cord-001734-bbeznd3r	343	5	surveillance	surveillance	NN
cord-001734-bbeznd3r	343	6	:	:	:
cord-001734-bbeznd3r	343	7	a	a	DT
cord-001734-bbeznd3r	343	8	report	report	NN
cord-001734-bbeznd3r	343	9	from	from	IN
cord-001734-bbeznd3r	343	10	the	the	DT
cord-001734-bbeznd3r	343	11	Asia	Asia	NNP
cord-001734-bbeznd3r	343	12	-	-	HYPH
cord-001734-bbeznd3r	343	13	Pacific	Pacific	NNP
cord-001734-bbeznd3r	343	14	and	and	CC
cord-001734-bbeznd3r	343	15	Americas	Americas	NNP
cord-001734-bbeznd3r	343	16	Dengue	Dengue	NNP
cord-001734-bbeznd3r	343	17	Prevention	Prevention	NNP
cord-001734-bbeznd3r	343	18	Boards	board	NNS
cord-001734-bbeznd3r	344	1	The	the	DT
cord-001734-bbeznd3r	344	2	global	global	JJ
cord-001734-bbeznd3r	344	3	distribution	distribution	NN
cord-001734-bbeznd3r	344	4	and	and	CC
cord-001734-bbeznd3r	344	5	burden	burden	NN
cord-001734-bbeznd3r	344	6	of	of	IN
cord-001734-bbeznd3r	344	7	dengue	dengue	NN
cord-001734-bbeznd3r	345	1	The	the	DT
cord-001734-bbeznd3r	345	2	dengue	dengue	NN
cord-001734-bbeznd3r	345	3	viruses	viruse	VBZ
cord-001734-bbeznd3r	345	4	Dengue	dengue	NN
cord-001734-bbeznd3r	345	5	:	:	:
cord-001734-bbeznd3r	345	6	a	a	DT
cord-001734-bbeznd3r	345	7	continuing	continue	VBG
cord-001734-bbeznd3r	345	8	global	global	JJ
cord-001734-bbeznd3r	345	9	threat	threat	NN
cord-001734-bbeznd3r	345	10	Structural	structural	JJ
cord-001734-bbeznd3r	345	11	proteomics	proteomic	NNS
cord-001734-bbeznd3r	345	12	of	of	IN
cord-001734-bbeznd3r	345	13	dengue	dengue	NN
cord-001734-bbeznd3r	345	14	virus	virus	NN
cord-001734-bbeznd3r	345	15	Structural	structural	JJ
cord-001734-bbeznd3r	345	16	biology	biology	NN
cord-001734-bbeznd3r	345	17	of	of	IN
cord-001734-bbeznd3r	345	18	dengue	dengue	NN
cord-001734-bbeznd3r	345	19	virus	virus	NN
cord-001734-bbeznd3r	345	20	enzymes	enzyme	NNS
cord-001734-bbeznd3r	345	21	:	:	:
cord-001734-bbeznd3r	345	22	towards	towards	IN
cord-001734-bbeznd3r	345	23	rational	rational	JJ
cord-001734-bbeznd3r	345	24	design	design	NN
cord-001734-bbeznd3r	345	25	of	of	IN
cord-001734-bbeznd3r	345	26	therapeutics	therapeutic	NNS
cord-001734-bbeznd3r	345	27	Structural	structural	JJ
cord-001734-bbeznd3r	345	28	basis	basis	NN
cord-001734-bbeznd3r	345	29	for	for	IN
cord-001734-bbeznd3r	345	30	the	the	DT
cord-001734-bbeznd3r	345	31	activation	activation	NN
cord-001734-bbeznd3r	345	32	of	of	IN
cord-001734-bbeznd3r	345	33	flaviviral	flaviviral	NN
cord-001734-bbeznd3r	345	34	NS3	ns3	RB
cord-001734-bbeznd3r	345	35	proteases	protease	NNS
cord-001734-bbeznd3r	345	36	from	from	IN
cord-001734-bbeznd3r	345	37	dengue	dengue	NN
cord-001734-bbeznd3r	345	38	and	and	CC
cord-001734-bbeznd3r	345	39	West	West	NNP
cord-001734-bbeznd3r	345	40	Nile	Nile	NNP
cord-001734-bbeznd3r	345	41	virus	virus	NN
cord-001734-bbeznd3r	345	42	Ligand	ligand	NN
cord-001734-bbeznd3r	345	43	-	-	HYPH
cord-001734-bbeznd3r	345	44	bound	bind	VBN
cord-001734-bbeznd3r	345	45	structures	structure	NNS
cord-001734-bbeznd3r	345	46	of	of	IN
cord-001734-bbeznd3r	345	47	the	the	DT
cord-001734-bbeznd3r	345	48	dengue	dengue	NN
cord-001734-bbeznd3r	345	49	virus	virus	NN
cord-001734-bbeznd3r	345	50	protease	protease	NN
cord-001734-bbeznd3r	345	51	reveal	reveal	VBP
cord-001734-bbeznd3r	345	52	the	the	DT
cord-001734-bbeznd3r	345	53	active	active	JJ
cord-001734-bbeznd3r	345	54	conformation	conformation	NN
cord-001734-bbeznd3r	345	55	Binding	Binding	NNP
cord-001734-bbeznd3r	345	56	of	of	IN
cord-001734-bbeznd3r	345	57	low	low	JJ
cord-001734-bbeznd3r	345	58	molecular	molecular	JJ
cord-001734-bbeznd3r	345	59	weight	weight	NN
cord-001734-bbeznd3r	345	60	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	345	61	promotes	promote	VBZ
cord-001734-bbeznd3r	345	62	large	large	JJ
cord-001734-bbeznd3r	345	63	conformational	conformational	JJ
cord-001734-bbeznd3r	345	64	changes	change	NNS
cord-001734-bbeznd3r	345	65	in	in	IN
cord-001734-bbeznd3r	345	66	the	the	DT
cord-001734-bbeznd3r	345	67	dengue	dengue	NN
cord-001734-bbeznd3r	345	68	virus	virus	NN
cord-001734-bbeznd3r	345	69	NS2B	NS2B	NNP
cord-001734-bbeznd3r	345	70	-	-	:
cord-001734-bbeznd3r	345	71	NS3	ns3	RB
cord-001734-bbeznd3r	345	72	protease	protease	NN
cord-001734-bbeznd3r	345	73	:	:	:
cord-001734-bbeznd3r	345	74	fold	fold	VB
cord-001734-bbeznd3r	345	75	analysis	analysis	NN
cord-001734-bbeznd3r	345	76	by	by	IN
cord-001734-bbeznd3r	345	77	pseudocontact	pseudocontact	NN
cord-001734-bbeznd3r	345	78	shifts	shift	VBZ
cord-001734-bbeznd3r	345	79	NMR	NMR	NNP
cord-001734-bbeznd3r	345	80	analysis	analysis	NN
cord-001734-bbeznd3r	345	81	of	of	IN
cord-001734-bbeznd3r	345	82	a	a	DT
cord-001734-bbeznd3r	345	83	novel	novel	NN
cord-001734-bbeznd3r	345	84	enzymatically	enzymatically	RB
cord-001734-bbeznd3r	345	85	active	active	JJ
cord-001734-bbeznd3r	345	86	unlinked	unlinked	JJ
cord-001734-bbeznd3r	345	87	dengue	dengue	NN
cord-001734-bbeznd3r	346	1	NS2B	NS2B	NNP
cord-001734-bbeznd3r	346	2	-	-	:
cord-001734-bbeznd3r	346	3	NS3	ns3	RB
cord-001734-bbeznd3r	346	4	protease	protease	NN
cord-001734-bbeznd3r	346	5	complex	complex	NN
cord-001734-bbeznd3r	347	1	Binding	binding	NN
cord-001734-bbeznd3r	347	2	mode	mode	NN
cord-001734-bbeznd3r	347	3	of	of	IN
cord-001734-bbeznd3r	347	4	the	the	DT
cord-001734-bbeznd3r	347	5	activity	activity	NN
cord-001734-bbeznd3r	347	6	-	-	HYPH
cord-001734-bbeznd3r	347	7	modulating	modulate	VBG
cord-001734-bbeznd3r	347	8	C	c	NN
cord-001734-bbeznd3r	347	9	-	-	HYPH
cord-001734-bbeznd3r	347	10	terminal	terminal	NN
cord-001734-bbeznd3r	347	11	segment	segment	NN
cord-001734-bbeznd3r	347	12	of	of	IN
cord-001734-bbeznd3r	347	13	NS2B	NS2B	NNP
cord-001734-bbeznd3r	347	14	to	to	TO
cord-001734-bbeznd3r	347	15	NS3	ns3	RB
cord-001734-bbeznd3r	347	16	in	in	IN
cord-001734-bbeznd3r	347	17	the	the	DT
cord-001734-bbeznd3r	347	18	dengue	dengue	NN
cord-001734-bbeznd3r	347	19	virus	virus	NN
cord-001734-bbeznd3r	347	20	NS2B	NS2B	NNP
cord-001734-bbeznd3r	347	21	-	-	:
cord-001734-bbeznd3r	347	22	NS3	ns3	RB
cord-001734-bbeznd3r	347	23	protease	protease	NN
cord-001734-bbeznd3r	348	1	The	the	DT
cord-001734-bbeznd3r	348	2	dengue	dengue	NN
cord-001734-bbeznd3r	348	3	virus	virus	NN
cord-001734-bbeznd3r	348	4	NS2B	NS2B	NNP
cord-001734-bbeznd3r	348	5	-	-	:
cord-001734-bbeznd3r	348	6	NS3	ns3	RB
cord-001734-bbeznd3r	348	7	protease	protease	NN
cord-001734-bbeznd3r	348	8	retains	retain	VBZ
cord-001734-bbeznd3r	348	9	the	the	DT
cord-001734-bbeznd3r	348	10	closed	closed	JJ
cord-001734-bbeznd3r	348	11	conformation	conformation	NN
cord-001734-bbeznd3r	348	12	in	in	IN
cord-001734-bbeznd3r	348	13	the	the	DT
cord-001734-bbeznd3r	348	14	complex	complex	NN
cord-001734-bbeznd3r	348	15	with	with	IN
cord-001734-bbeznd3r	348	16	BPTI	BPTI	NNP
cord-001734-bbeznd3r	348	17	Mechanism	Mechanism	NNP
cord-001734-bbeznd3r	348	18	of	of	IN
cord-001734-bbeznd3r	348	19	NS2B	NS2B	NNP
cord-001734-bbeznd3r	348	20	-	-	HYPH
cord-001734-bbeznd3r	348	21	mediated	mediate	VBN
cord-001734-bbeznd3r	348	22	activation	activation	NN
cord-001734-bbeznd3r	348	23	of	of	IN
cord-001734-bbeznd3r	348	24	NS3pro	NS3pro	NNP
cord-001734-bbeznd3r	348	25	in	in	IN
cord-001734-bbeznd3r	348	26	dengue	dengue	NN
cord-001734-bbeznd3r	348	27	virus	virus	NN
cord-001734-bbeznd3r	348	28	:	:	:
cord-001734-bbeznd3r	348	29	molecular	molecular	JJ
cord-001734-bbeznd3r	348	30	dynamics	dynamic	NNS
cord-001734-bbeznd3r	348	31	simulations	simulation	NNS
cord-001734-bbeznd3r	348	32	and	and	CC
cord-001734-bbeznd3r	348	33	bioassays	bioassays	JJ
cord-001734-bbeznd3r	348	34	New	new	JJ
cord-001734-bbeznd3r	348	35	binding	bind	VBG
cord-001734-bbeznd3r	348	36	site	site	NN
cord-001734-bbeznd3r	348	37	conformations	conformation	NNS
cord-001734-bbeznd3r	348	38	of	of	IN
cord-001734-bbeznd3r	348	39	the	the	DT
cord-001734-bbeznd3r	348	40	dengue	dengue	NN
cord-001734-bbeznd3r	348	41	virus	virus	NN
cord-001734-bbeznd3r	348	42	NS3	ns3	RB
cord-001734-bbeznd3r	348	43	protease	protease	NN
cord-001734-bbeznd3r	348	44	accessed	access	VBN
cord-001734-bbeznd3r	348	45	by	by	IN
cord-001734-bbeznd3r	348	46	molecular	molecular	JJ
cord-001734-bbeznd3r	348	47	dynamics	dynamic	NNS
cord-001734-bbeznd3r	348	48	simulation	simulation	NN
cord-001734-bbeznd3r	348	49	Resurrecting	resurrect	VBG
cord-001734-bbeznd3r	348	50	abandoned	abandon	VBN
cord-001734-bbeznd3r	348	51	proteins	protein	NNS
cord-001734-bbeznd3r	348	52	with	with	IN
cord-001734-bbeznd3r	348	53	pure	pure	JJ
cord-001734-bbeznd3r	348	54	water	water	NN
cord-001734-bbeznd3r	348	55	:	:	:
cord-001734-bbeznd3r	348	56	CD	CD	NNP
cord-001734-bbeznd3r	348	57	and	and	CC
cord-001734-bbeznd3r	348	58	NMR	NMR	NNP
cord-001734-bbeznd3r	348	59	studies	study	NNS
cord-001734-bbeznd3r	348	60	of	of	IN
cord-001734-bbeznd3r	348	61	protein	protein	NN
cord-001734-bbeznd3r	348	62	fragments	fragment	NNS
cord-001734-bbeznd3r	348	63	solubilized	solubilize	VBN
cord-001734-bbeznd3r	348	64	in	in	IN
cord-001734-bbeznd3r	348	65	salt	salt	NN
cord-001734-bbeznd3r	348	66	-	-	HYPH
cord-001734-bbeznd3r	348	67	free	free	JJ
cord-001734-bbeznd3r	348	68	water	water	NN
cord-001734-bbeznd3r	348	69	Insight	Insight	NNP
cord-001734-bbeznd3r	348	70	into	into	IN
cord-001734-bbeznd3r	348	71	"	"	``
cord-001734-bbeznd3r	348	72	insoluble	insoluble	JJ
cord-001734-bbeznd3r	348	73	proteins	protein	NNS
cord-001734-bbeznd3r	348	74	"	"	''
cord-001734-bbeznd3r	348	75	with	with	IN
cord-001734-bbeznd3r	348	76	pure	pure	JJ
cord-001734-bbeznd3r	348	77	water	water	NN
cord-001734-bbeznd3r	348	78	Intrinsically	intrinsically	RB
cord-001734-bbeznd3r	348	79	insoluble	insoluble	JJ
cord-001734-bbeznd3r	348	80	proteins	protein	NNS
cord-001734-bbeznd3r	348	81	"	"	''
cord-001734-bbeznd3r	348	82	and	and	CC
cord-001734-bbeznd3r	348	83	"	"	``
cord-001734-bbeznd3r	348	84	dark	dark	JJ
cord-001734-bbeznd3r	348	85	mediators	mediator	NNS
cord-001734-bbeznd3r	348	86	"	"	''
cord-001734-bbeznd3r	348	87	revealed	reveal	VBN
cord-001734-bbeznd3r	348	88	by	by	IN
cord-001734-bbeznd3r	348	89	studies	study	NNS
cord-001734-bbeznd3r	348	90	on	on	IN
cord-001734-bbeznd3r	348	91	"	"	``
cord-001734-bbeznd3r	348	92	insoluble	insoluble	JJ
cord-001734-bbeznd3r	348	93	proteins	protein	NNS
cord-001734-bbeznd3r	348	94	Resolving	resolve	VBG
cord-001734-bbeznd3r	348	95	the	the	DT
cord-001734-bbeznd3r	348	96	paradox	paradox	NN
cord-001734-bbeznd3r	348	97	for	for	IN
cord-001734-bbeznd3r	348	98	protein	protein	NN
cord-001734-bbeznd3r	348	99	aggregation	aggregation	NN
cord-001734-bbeznd3r	348	100	diseases	disease	NNS
cord-001734-bbeznd3r	348	101	:	:	:
cord-001734-bbeznd3r	349	1	NMR	NMR	NNP
cord-001734-bbeznd3r	349	2	structure	structure	NN
cord-001734-bbeznd3r	349	3	and	and	CC
cord-001734-bbeznd3r	349	4	dynamics	dynamic	NNS
cord-001734-bbeznd3r	349	5	of	of	IN
cord-001734-bbeznd3r	349	6	the	the	DT
cord-001734-bbeznd3r	349	7	membrane	membrane	NN
cord-001734-bbeznd3r	349	8	-	-	HYPH
cord-001734-bbeznd3r	349	9	embedded	embed	VBN
cord-001734-bbeznd3r	349	10	P56S	P56S	NNP
cord-001734-bbeznd3r	349	11	-	-	HYPH
cord-001734-bbeznd3r	349	12	MSP	MSP	NNP
cord-001734-bbeznd3r	349	13	causing	cause	VBG
cord-001734-bbeznd3r	349	14	ALS	ALS	NNP
cord-001734-bbeznd3r	349	15	imply	imply	VBP
cord-001734-bbeznd3r	349	16	a	a	DT
cord-001734-bbeznd3r	349	17	common	common	JJ
cord-001734-bbeznd3r	349	18	mechanism	mechanism	NN
cord-001734-bbeznd3r	349	19	for	for	IN
cord-001734-bbeznd3r	349	20	aggregation	aggregation	NN
cord-001734-bbeznd3r	349	21	-	-	HYPH
cord-001734-bbeznd3r	349	22	prone	prone	JJ
cord-001734-bbeznd3r	349	23	proteins	protein	NNS
cord-001734-bbeznd3r	350	1	to	to	TO
cord-001734-bbeznd3r	350	2	attack	attack	VB
cord-001734-bbeznd3r	350	3	membranes	membrane	NNS
cord-001734-bbeznd3r	350	4	TDP-43	TDP-43	NNP
cord-001734-bbeznd3r	350	5	N	n	CD
cord-001734-bbeznd3r	350	6	terminus	terminus	NN
cord-001734-bbeznd3r	350	7	encodes	encode	VBZ
cord-001734-bbeznd3r	350	8	a	a	DT
cord-001734-bbeznd3r	350	9	novel	novel	JJ
cord-001734-bbeznd3r	350	10	ubiquitin	ubiquitin	NN
cord-001734-bbeznd3r	350	11	-	-	HYPH
cord-001734-bbeznd3r	350	12	like	like	JJ
cord-001734-bbeznd3r	350	13	fold	fold	NN
cord-001734-bbeznd3r	350	14	and	and	CC
cord-001734-bbeznd3r	350	15	its	-PRON-	PRP$
cord-001734-bbeznd3r	350	16	unfolded	unfold	VBN
cord-001734-bbeznd3r	350	17	form	form	NN
cord-001734-bbeznd3r	350	18	in	in	IN
cord-001734-bbeznd3r	350	19	equilibrium	equilibrium	NN
cord-001734-bbeznd3r	350	20	that	that	WDT
cord-001734-bbeznd3r	350	21	can	can	MD
cord-001734-bbeznd3r	350	22	be	be	VB
cord-001734-bbeznd3r	350	23	shifted	shift	VBN
cord-001734-bbeznd3r	350	24	by	by	IN
cord-001734-bbeznd3r	350	25	binding	bind	VBG
cord-001734-bbeznd3r	350	26	to	to	IN
cord-001734-bbeznd3r	350	27	ssDNA	ssDNA	VBG
cord-001734-bbeznd3r	350	28	Dynamically	dynamically	RB
cord-001734-bbeznd3r	350	29	-	-	HYPH
cord-001734-bbeznd3r	350	30	driven	drive	VBN
cord-001734-bbeznd3r	350	31	inactivation	inactivation	NN
cord-001734-bbeznd3r	350	32	of	of	IN
cord-001734-bbeznd3r	350	33	the	the	DT
cord-001734-bbeznd3r	350	34	catalytic	catalytic	JJ
cord-001734-bbeznd3r	350	35	machinery	machinery	NN
cord-001734-bbeznd3r	350	36	of	of	IN
cord-001734-bbeznd3r	350	37	the	the	DT
cord-001734-bbeznd3r	350	38	SARS	SARS	NNP
cord-001734-bbeznd3r	350	39	3C	3C	NNP
cord-001734-bbeznd3r	350	40	-	-	HYPH
cord-001734-bbeznd3r	350	41	like	like	JJ
cord-001734-bbeznd3r	350	42	protease	protease	NN
cord-001734-bbeznd3r	350	43	by	by	IN
cord-001734-bbeznd3r	350	44	the	the	DT
cord-001734-bbeznd3r	350	45	N214A	N214A	NNP
cord-001734-bbeznd3r	350	46	mutation	mutation	NN
cord-001734-bbeznd3r	350	47	on	on	IN
cord-001734-bbeznd3r	350	48	the	the	DT
cord-001734-bbeznd3r	350	49	extra	extra	JJ
cord-001734-bbeznd3r	350	50	domain	domain	NN
cord-001734-bbeznd3r	350	51	Dynamically	dynamically	RB
cord-001734-bbeznd3r	350	52	-	-	HYPH
cord-001734-bbeznd3r	350	53	driven	drive	VBN
cord-001734-bbeznd3r	350	54	enhancement	enhancement	NN
cord-001734-bbeznd3r	350	55	of	of	IN
cord-001734-bbeznd3r	350	56	the	the	DT
cord-001734-bbeznd3r	350	57	catalytic	catalytic	JJ
cord-001734-bbeznd3r	350	58	machinery	machinery	NN
cord-001734-bbeznd3r	350	59	of	of	IN
cord-001734-bbeznd3r	350	60	the	the	DT
cord-001734-bbeznd3r	350	61	SARS	SARS	NNP
cord-001734-bbeznd3r	350	62	3C	3C	NNP
cord-001734-bbeznd3r	350	63	-	-	HYPH
cord-001734-bbeznd3r	350	64	Like	like	JJ
cord-001734-bbeznd3r	350	65	protease	protease	NN
cord-001734-bbeznd3r	350	66	by	by	IN
cord-001734-bbeznd3r	350	67	the	the	DT
cord-001734-bbeznd3r	350	68	S284-T285-I286	S284-T285-I286	NNP
cord-001734-bbeznd3r	350	69	/	/	SYM
cord-001734-bbeznd3r	350	70	A	A	NNP
cord-001734-bbeznd3r	350	71	mutations	mutation	NNS
cord-001734-bbeznd3r	350	72	on	on	IN
cord-001734-bbeznd3r	350	73	the	the	DT
cord-001734-bbeznd3r	350	74	extra	extra	JJ
cord-001734-bbeznd3r	350	75	domain	domain	NN
cord-001734-bbeznd3r	350	76	Intrinsically	intrinsically	RB
cord-001734-bbeznd3r	350	77	unstructured	unstructured	JJ
cord-001734-bbeznd3r	350	78	domain	domain	NN
cord-001734-bbeznd3r	350	79	3	3	CD
cord-001734-bbeznd3r	350	80	of	of	IN
cord-001734-bbeznd3r	350	81	hepatitis	hepatitis	NN
cord-001734-bbeznd3r	350	82	C	C	NNP
cord-001734-bbeznd3r	350	83	Virus	virus	NN
cord-001734-bbeznd3r	351	1	NS5A	NS5A	NNP
cord-001734-bbeznd3r	351	2	forms	form	VBZ
cord-001734-bbeznd3r	351	3	a	a	DT
cord-001734-bbeznd3r	351	4	"	"	``
cord-001734-bbeznd3r	351	5	fuzzy	fuzzy	JJ
cord-001734-bbeznd3r	351	6	complex	complex	NN
cord-001734-bbeznd3r	351	7	"	"	''
cord-001734-bbeznd3r	351	8	with	with	IN
cord-001734-bbeznd3r	351	9	VAPB	VAPB	NNP
cord-001734-bbeznd3r	351	10	-	-	HYPH
cord-001734-bbeznd3r	351	11	MSP	MSP	NNP
cord-001734-bbeznd3r	351	12	domain	domain	NN
cord-001734-bbeznd3r	351	13	which	which	WDT
cord-001734-bbeznd3r	351	14	carries	carry	VBZ
cord-001734-bbeznd3r	351	15	ALS	als	NN
cord-001734-bbeznd3r	351	16	-	-	HYPH
cord-001734-bbeznd3r	351	17	causing	cause	VBG
cord-001734-bbeznd3r	351	18	mutations	mutation	NNS
cord-001734-bbeznd3r	351	19	How	how	WRB
cord-001734-bbeznd3r	351	20	to	to	TO
cord-001734-bbeznd3r	351	21	measure	measure	VB
cord-001734-bbeznd3r	351	22	and	and	CC
cord-001734-bbeznd3r	351	23	predict	predict	VB
cord-001734-bbeznd3r	351	24	the	the	DT
cord-001734-bbeznd3r	351	25	molar	molar	JJ
cord-001734-bbeznd3r	351	26	absorption	absorption	NN
cord-001734-bbeznd3r	351	27	coefficient	coefficient	NN
cord-001734-bbeznd3r	351	28	of	of	IN
cord-001734-bbeznd3r	351	29	a	a	DT
cord-001734-bbeznd3r	351	30	protein	protein	NN
cord-001734-bbeznd3r	351	31	NMRPipe	nmrpipe	NN
cord-001734-bbeznd3r	351	32	:	:	:
cord-001734-bbeznd3r	351	33	a	a	DT
cord-001734-bbeznd3r	351	34	multidimensional	multidimensional	JJ
cord-001734-bbeznd3r	351	35	spectral	spectral	JJ
cord-001734-bbeznd3r	351	36	processing	processing	NN
cord-001734-bbeznd3r	351	37	system	system	NN
cord-001734-bbeznd3r	351	38	based	base	VBN
cord-001734-bbeznd3r	351	39	on	on	IN
cord-001734-bbeznd3r	351	40	UNIX	UNIX	NNP
cord-001734-bbeznd3r	351	41	pipes	pipe	NNS
cord-001734-bbeznd3r	351	42	NMRView	nmrview	JJ
cord-001734-bbeznd3r	351	43	:	:	:
cord-001734-bbeznd3r	352	1	A	a	DT
cord-001734-bbeznd3r	352	2	computer	computer	NN
cord-001734-bbeznd3r	352	3	program	program	NN
cord-001734-bbeznd3r	352	4	for	for	IN
cord-001734-bbeznd3r	352	5	the	the	DT
cord-001734-bbeznd3r	352	6	visualization	visualization	NN
cord-001734-bbeznd3r	352	7	and	and	CC
cord-001734-bbeznd3r	352	8	analysis	analysis	NN
cord-001734-bbeznd3r	352	9	of	of	IN
cord-001734-bbeznd3r	352	10	NMR	NMR	NNP
cord-001734-bbeznd3r	352	11	data	data	NN
cord-001734-bbeznd3r	352	12	Determination	determination	NN
cord-001734-bbeznd3r	352	13	of	of	IN
cord-001734-bbeznd3r	352	14	secondary	secondary	JJ
cord-001734-bbeznd3r	352	15	structure	structure	NN
cord-001734-bbeznd3r	352	16	populations	population	NNS
cord-001734-bbeznd3r	352	17	in	in	IN
cord-001734-bbeznd3r	352	18	disordered	disordered	JJ
cord-001734-bbeznd3r	352	19	states	state	NNS
cord-001734-bbeznd3r	352	20	of	of	IN
cord-001734-bbeznd3r	352	21	proteins	protein	NNS
cord-001734-bbeznd3r	352	22	using	use	VBG
cord-001734-bbeznd3r	352	23	nuclear	nuclear	JJ
cord-001734-bbeznd3r	352	24	magnetic	magnetic	JJ
cord-001734-bbeznd3r	352	25	resonance	resonance	NN
cord-001734-bbeznd3r	352	26	chemical	chemical	NN
cord-001734-bbeznd3r	352	27	shifts	shift	NNS
cord-001734-bbeznd3r	352	28	Algorithms	Algorithms	NNP
cord-001734-bbeznd3r	352	29	for	for	IN
cord-001734-bbeznd3r	352	30	Highly	highly	RB
cord-001734-bbeznd3r	352	31	Efficient	efficient	JJ
cord-001734-bbeznd3r	352	32	,	,	,
cord-001734-bbeznd3r	352	33	Load	Load	NNP
cord-001734-bbeznd3r	352	34	-	-	HYPH
cord-001734-bbeznd3r	352	35	Balanced	Balanced	NNP
cord-001734-bbeznd3r	352	36	,	,	,
cord-001734-bbeznd3r	352	37	and	and	CC
cord-001734-bbeznd3r	352	38	Scalable	Scalable	NNP
cord-001734-bbeznd3r	352	39	Molecular	Molecular	NNP
cord-001734-bbeznd3r	352	40	Simulation	Simulation	NNP
cord-001734-bbeznd3r	353	1	A	a	DT
cord-001734-bbeznd3r	353	2	point	point	NN
cord-001734-bbeznd3r	353	3	-	-	HYPH
cord-001734-bbeznd3r	353	4	charge	charge	NN
cord-001734-bbeznd3r	353	5	force	force	NN
cord-001734-bbeznd3r	353	6	field	field	NN
cord-001734-bbeznd3r	353	7	for	for	IN
cord-001734-bbeznd3r	353	8	molecular	molecular	JJ
cord-001734-bbeznd3r	353	9	mechanics	mechanic	NNS
cord-001734-bbeznd3r	353	10	simulations	simulation	NNS
cord-001734-bbeznd3r	353	11	of	of	IN
cord-001734-bbeznd3r	353	12	proteins	protein	NNS
cord-001734-bbeznd3r	353	13	based	base	VBN
cord-001734-bbeznd3r	353	14	on	on	IN
cord-001734-bbeznd3r	353	15	condensedphase	condensedphase	NN
cord-001734-bbeznd3r	353	16	quantum	quantum	JJ
cord-001734-bbeznd3r	353	17	mechanical	mechanical	JJ
cord-001734-bbeznd3r	353	18	calculations	calculation	NNS
cord-001734-bbeznd3r	353	19	LINCS	LINCS	NNP
cord-001734-bbeznd3r	353	20	:	:	:
cord-001734-bbeznd3r	354	1	A	a	DT
cord-001734-bbeznd3r	354	2	linear	linear	JJ
cord-001734-bbeznd3r	354	3	constraint	constraint	NN
cord-001734-bbeznd3r	354	4	solver	solver	NN
cord-001734-bbeznd3r	354	5	for	for	IN
cord-001734-bbeznd3r	354	6	molecular	molecular	JJ
cord-001734-bbeznd3r	354	7	simulations	simulation	NNS
cord-001734-bbeznd3r	354	8	Quantifying	quantify	VBG
cord-001734-bbeznd3r	354	9	correlations	correlation	NNS
cord-001734-bbeznd3r	354	10	between	between	IN
cord-001734-bbeznd3r	354	11	allosteric	allosteric	JJ
cord-001734-bbeznd3r	354	12	sites	site	NNS
cord-001734-bbeznd3r	354	13	in	in	IN
cord-001734-bbeznd3r	354	14	thermodynamic	thermodynamic	JJ
cord-001734-bbeznd3r	354	15	ensembles	ensemble	NNS
cord-001734-bbeznd3r	354	16	NMR	NMR	NNP
cord-001734-bbeznd3r	354	17	evidence	evidence	NN
cord-001734-bbeznd3r	354	18	for	for	IN
cord-001734-bbeznd3r	354	19	forming	form	VBG
cord-001734-bbeznd3r	354	20	highly	highly	RB
cord-001734-bbeznd3r	354	21	populated	populated	JJ
cord-001734-bbeznd3r	354	22	helical	helical	JJ
cord-001734-bbeznd3r	354	23	conformations	conformation	NNS
cord-001734-bbeznd3r	354	24	in	in	IN
cord-001734-bbeznd3r	354	25	the	the	DT
cord-001734-bbeznd3r	354	26	partially	partially	RB
cord-001734-bbeznd3r	354	27	folded	fold	VBN
cord-001734-bbeznd3r	354	28	hNck2	hNck2	NNP
cord-001734-bbeznd3r	354	29	SH3	SH3	NNP
cord-001734-bbeznd3r	354	30	domain	domain	NN
cord-001734-bbeznd3r	354	31	Unfolded	unfold	VBD
cord-001734-bbeznd3r	354	32	proteins	protein	NNS
cord-001734-bbeznd3r	354	33	and	and	CC
cord-001734-bbeznd3r	354	34	protein	protein	NN
cord-001734-bbeznd3r	354	35	folding	folding	NN
cord-001734-bbeznd3r	354	36	studied	study	VBN
cord-001734-bbeznd3r	354	37	by	by	IN
cord-001734-bbeznd3r	354	38	NMR	NMR	NNP
cord-001734-bbeznd3r	354	39	Intrinsically	intrinsically	RB
cord-001734-bbeznd3r	354	40	unstructured	unstructured	JJ
cord-001734-bbeznd3r	354	41	proteins	protein	NNS
cord-001734-bbeznd3r	354	42	and	and	CC
cord-001734-bbeznd3r	354	43	their	-PRON-	PRP$
cord-001734-bbeznd3r	354	44	functions	function	NNS
cord-001734-bbeznd3r	354	45	Intrinsically	intrinsically	RB
cord-001734-bbeznd3r	354	46	unstructured	unstructured	JJ
cord-001734-bbeznd3r	354	47	proteins	protein	NNS
cord-001734-bbeznd3r	354	48	Classification	Classification	NNP
cord-001734-bbeznd3r	354	49	of	of	IN
cord-001734-bbeznd3r	354	50	intrinsically	intrinsically	RB
cord-001734-bbeznd3r	354	51	disordered	disordered	JJ
cord-001734-bbeznd3r	354	52	regions	region	NNS
cord-001734-bbeznd3r	354	53	and	and	CC
cord-001734-bbeznd3r	354	54	proteins	protein	NNS
cord-001734-bbeznd3r	354	55	Extended	extend	VBN
cord-001734-bbeznd3r	354	56	disordered	disordered	JJ
cord-001734-bbeznd3r	354	57	proteins	protein	NNS
cord-001734-bbeznd3r	354	58	:	:	:
cord-001734-bbeznd3r	354	59	targeting	target	VBG
cord-001734-bbeznd3r	354	60	function	function	NN
cord-001734-bbeznd3r	354	61	with	with	IN
cord-001734-bbeznd3r	354	62	less	less	JJR
cord-001734-bbeznd3r	354	63	scaffold	scaffold	NN
cord-001734-bbeznd3r	354	64	Backbone	backbone	NN
cord-001734-bbeznd3r	354	65	dynamics	dynamic	NNS
cord-001734-bbeznd3r	354	66	of	of	IN
cord-001734-bbeznd3r	354	67	a	a	DT
cord-001734-bbeznd3r	354	68	free	free	JJ
cord-001734-bbeznd3r	354	69	and	and	CC
cord-001734-bbeznd3r	354	70	phosphopeptide	phosphopeptide	JJ
cord-001734-bbeznd3r	354	71	-	-	HYPH
cord-001734-bbeznd3r	354	72	complexed	complexe	VBN
cord-001734-bbeznd3r	354	73	Src	Src	NNP
cord-001734-bbeznd3r	354	74	homology	homology	NN
cord-001734-bbeznd3r	354	75	2	2	CD
cord-001734-bbeznd3r	354	76	domain	domain	NN
cord-001734-bbeznd3r	354	77	studied	study	VBN
cord-001734-bbeznd3r	354	78	by	by	IN
cord-001734-bbeznd3r	354	79	15N	15n	CD
cord-001734-bbeznd3r	354	80	NMR	NMR	NNP
cord-001734-bbeznd3r	354	81	relaxation	relaxation	NN
cord-001734-bbeznd3r	354	82	Distance	distance	NN
cord-001734-bbeznd3r	354	83	information	information	NN
cord-001734-bbeznd3r	354	84	for	for	IN
cord-001734-bbeznd3r	354	85	disordered	disordered	JJ
cord-001734-bbeznd3r	354	86	proteins	protein	NNS
cord-001734-bbeznd3r	354	87	from	from	IN
cord-001734-bbeznd3r	354	88	NMR	NMR	NNP
cord-001734-bbeznd3r	354	89	and	and	CC
cord-001734-bbeznd3r	354	90	ESR	ESR	NNP
cord-001734-bbeznd3r	354	91	measurements	measurement	NNS
cord-001734-bbeznd3r	354	92	using	use	VBG
cord-001734-bbeznd3r	354	93	paramagnetic	paramagnetic	JJ
cord-001734-bbeznd3r	354	94	spin	spin	NN
cord-001734-bbeznd3r	354	95	labels	label	VBZ
cord-001734-bbeznd3r	354	96	A	a	DT
cord-001734-bbeznd3r	354	97	gradual	gradual	JJ
cord-001734-bbeznd3r	354	98	disruption	disruption	NN
cord-001734-bbeznd3r	354	99	of	of	IN
cord-001734-bbeznd3r	354	100	tight	tight	JJ
cord-001734-bbeznd3r	354	101	side	side	JJ
cord-001734-bbeznd3r	354	102	-	-	HYPH
cord-001734-bbeznd3r	354	103	chain	chain	NN
cord-001734-bbeznd3r	354	104	packing	packing	NN
cord-001734-bbeznd3r	354	105	:	:	:
cord-001734-bbeznd3r	355	1	2D	2D	NNP
cord-001734-bbeznd3r	355	2	1H	1H	NNP
cord-001734-bbeznd3r	355	3	-	-	HYPH
cord-001734-bbeznd3r	355	4	NMR	nmr	NN
cord-001734-bbeznd3r	355	5	characterization	characterization	NN
cord-001734-bbeznd3r	355	6	of	of	IN
cord-001734-bbeznd3r	355	7	acid	acid	NN
cord-001734-bbeznd3r	355	8	-	-	HYPH
cord-001734-bbeznd3r	355	9	induced	induce	VBN
cord-001734-bbeznd3r	355	10	unfolding	unfolding	NN
cord-001734-bbeznd3r	355	11	of	of	IN
cord-001734-bbeznd3r	355	12	CHABII	CHABII	NNP
cord-001734-bbeznd3r	355	13	Molecular	Molecular	NNP
cord-001734-bbeznd3r	355	14	mechanism	mechanism	NN
cord-001734-bbeznd3r	355	15	underlying	underlie	VBG
cord-001734-bbeznd3r	355	16	the	the	DT
cord-001734-bbeznd3r	355	17	thermal	thermal	JJ
cord-001734-bbeznd3r	355	18	stability	stability	NN
cord-001734-bbeznd3r	355	19	and	and	CC
cord-001734-bbeznd3r	355	20	pH	ph	NN
cord-001734-bbeznd3r	355	21	-	-	HYPH
cord-001734-bbeznd3r	355	22	induced	induce	VBN
cord-001734-bbeznd3r	355	23	unfolding	unfolding	NN
cord-001734-bbeznd3r	355	24	of	of	IN
cord-001734-bbeznd3r	355	25	CHABII	CHABII	NNP
cord-001734-bbeznd3r	355	26	Mechanism	Mechanism	NNP
cord-001734-bbeznd3r	355	27	for	for	IN
cord-001734-bbeznd3r	355	28	transforming	transform	VBG
cord-001734-bbeznd3r	355	29	cytosolic	cytosolic	JJ
cord-001734-bbeznd3r	355	30	SOD1	SOD1	NNP
cord-001734-bbeznd3r	355	31	into	into	IN
cord-001734-bbeznd3r	355	32	integral	integral	JJ
cord-001734-bbeznd3r	355	33	membrane	membrane	NN
cord-001734-bbeznd3r	355	34	proteins	protein	NNS
cord-001734-bbeznd3r	355	35	of	of	IN
cord-001734-bbeznd3r	355	36	organelles	organelle	NNS
cord-001734-bbeznd3r	355	37	by	by	IN
cord-001734-bbeznd3r	355	38	ALS	als	NN
cord-001734-bbeznd3r	355	39	-	-	HYPH
cord-001734-bbeznd3r	355	40	causing	cause	VBG
cord-001734-bbeznd3r	355	41	mutations	mutation	NNS
cord-001734-bbeznd3r	356	1	Viral	viral	JJ
cord-001734-bbeznd3r	356	2	proteases	protease	NNS
cord-001734-bbeznd3r	357	1	The	the	DT
cord-001734-bbeznd3r	357	2	design	design	NN
cord-001734-bbeznd3r	357	3	of	of	IN
cord-001734-bbeznd3r	357	4	drugs	drug	NNS
cord-001734-bbeznd3r	357	5	for	for	IN
cord-001734-bbeznd3r	357	6	HIV	HIV	NNP
cord-001734-bbeznd3r	357	7	and	and	CC
cord-001734-bbeznd3r	357	8	HCV	HCV	NNP
cord-001734-bbeznd3r	357	9	New	New	NNP
cord-001734-bbeznd3r	357	10	Merck	Merck	NNP
cord-001734-bbeznd3r	357	11	and	and	CC
cord-001734-bbeznd3r	357	12	Vertex	Vertex	NNP
cord-001734-bbeznd3r	357	13	drugs	drug	NNS
cord-001734-bbeznd3r	357	14	raise	raise	VBP
cord-001734-bbeznd3r	357	15	standard	standard	NN
cord-001734-bbeznd3r	357	16	of	of	IN
cord-001734-bbeznd3r	357	17	care	care	NN
cord-001734-bbeznd3r	357	18	in	in	IN
cord-001734-bbeznd3r	357	19	hepatitis	hepatitis	NN
cord-001734-bbeznd3r	357	20	C	C	NNP
cord-001734-bbeznd3r	357	21	Allosteric	Allosteric	NNP
cord-001734-bbeznd3r	357	22	inhibition	inhibition	NN
cord-001734-bbeznd3r	357	23	of	of	IN
cord-001734-bbeznd3r	357	24	the	the	DT
cord-001734-bbeznd3r	357	25	NS2B	NS2B	NNP
cord-001734-bbeznd3r	357	26	-	-	:
cord-001734-bbeznd3r	357	27	NS3	ns3	RB
cord-001734-bbeznd3r	357	28	protease	protease	VBP
cord-001734-bbeznd3r	357	29	from	from	IN
cord-001734-bbeznd3r	357	30	dengue	dengue	NN
cord-001734-bbeznd3r	357	31	virus	virus	NN
cord-001734-bbeznd3r	357	32	Dissection	dissection	NN
cord-001734-bbeznd3r	357	33	study	study	NN
cord-001734-bbeznd3r	357	34	on	on	IN
cord-001734-bbeznd3r	357	35	the	the	DT
cord-001734-bbeznd3r	357	36	severe	severe	JJ
cord-001734-bbeznd3r	357	37	acute	acute	JJ
cord-001734-bbeznd3r	357	38	respiratory	respiratory	JJ
cord-001734-bbeznd3r	357	39	syndrome	syndrome	NN
cord-001734-bbeznd3r	358	1	3C	3c	NN
cord-001734-bbeznd3r	358	2	-	-	HYPH
cord-001734-bbeznd3r	358	3	like	like	JJ
cord-001734-bbeznd3r	358	4	protease	protease	NN
cord-001734-bbeznd3r	358	5	reveals	reveal	VBZ
cord-001734-bbeznd3r	358	6	the	the	DT
cord-001734-bbeznd3r	358	7	critical	critical	JJ
cord-001734-bbeznd3r	358	8	role	role	NN
cord-001734-bbeznd3r	358	9	of	of	IN
cord-001734-bbeznd3r	358	10	the	the	DT
cord-001734-bbeznd3r	358	11	extra	extra	JJ
cord-001734-bbeznd3r	358	12	domain	domain	NN
cord-001734-bbeznd3r	358	13	in	in	IN
cord-001734-bbeznd3r	358	14	dimerization	dimerization	NN
cord-001734-bbeznd3r	358	15	of	of	IN
cord-001734-bbeznd3r	358	16	the	the	DT
cord-001734-bbeznd3r	358	17	enzyme	enzyme	NN
cord-001734-bbeznd3r	358	18	:	:	:
cord-001734-bbeznd3r	358	19	defining	define	VBG
cord-001734-bbeznd3r	358	20	the	the	DT
cord-001734-bbeznd3r	358	21	extra	extra	JJ
cord-001734-bbeznd3r	358	22	domain	domain	NN
cord-001734-bbeznd3r	358	23	as	as	IN
cord-001734-bbeznd3r	358	24	a	a	DT
cord-001734-bbeznd3r	358	25	new	new	JJ
cord-001734-bbeznd3r	358	26	target	target	NN
cord-001734-bbeznd3r	358	27	for	for	IN
cord-001734-bbeznd3r	358	28	design	design	NN
cord-001734-bbeznd3r	358	29	of	of	IN
cord-001734-bbeznd3r	358	30	highly	highly	RB
cord-001734-bbeznd3r	358	31	specific	specific	JJ
cord-001734-bbeznd3r	358	32	protease	protease	NN
cord-001734-bbeznd3r	358	33	inhibitors	inhibitor	NNS
cord-001734-bbeznd3r	358	34	Dengue	dengue	NN
cord-001734-bbeznd3r	358	35	virus	virus	NN
cord-001734-bbeznd3r	358	36	nonstructural	nonstructural	JJ
cord-001734-bbeznd3r	358	37	protein	protein	NN
cord-001734-bbeznd3r	358	38	3	3	CD
cord-001734-bbeznd3r	358	39	redistributes	redistribute	VBZ
cord-001734-bbeznd3r	358	40	fatty	fatty	JJ
cord-001734-bbeznd3r	358	41	acid	acid	NN
cord-001734-bbeznd3r	358	42	synthase	synthase	NN
cord-001734-bbeznd3r	358	43	to	to	IN
cord-001734-bbeznd3r	358	44	sites	site	NNS
cord-001734-bbeznd3r	358	45	of	of	IN
cord-001734-bbeznd3r	358	46	viral	viral	JJ
cord-001734-bbeznd3r	358	47	replication	replication	NN
cord-001734-bbeznd3r	358	48	and	and	CC
cord-001734-bbeznd3r	358	49	increases	increase	VBZ
cord-001734-bbeznd3r	358	50	cellular	cellular	JJ
cord-001734-bbeznd3r	358	51	fatty	fatty	JJ
cord-001734-bbeznd3r	358	52	acid	acid	NN
cord-001734-bbeznd3r	358	53	synthesis	synthesis	NN
cord-001734-bbeznd3r	358	54	Modification	modification	NN
cord-001734-bbeznd3r	358	55	of	of	IN
cord-001734-bbeznd3r	358	56	intracellular	intracellular	JJ
cord-001734-bbeznd3r	358	57	membrane	membrane	NN
cord-001734-bbeznd3r	358	58	structures	structure	NNS
cord-001734-bbeznd3r	358	59	for	for	IN
cord-001734-bbeznd3r	358	60	virus	virus	NN
cord-001734-bbeznd3r	358	61	replication	replication	NN
cord-001734-bbeznd3r	358	62	Organelle	Organelle	NNP
cord-001734-bbeznd3r	358	63	-	-	HYPH
cord-001734-bbeznd3r	358	64	like	like	JJ
cord-001734-bbeznd3r	358	65	membrane	membrane	NN
cord-001734-bbeznd3r	358	66	compartmentalization	compartmentalization	NN
cord-001734-bbeznd3r	358	67	of	of	IN
cord-001734-bbeznd3r	358	68	positive	positive	JJ
cord-001734-bbeznd3r	358	69	-	-	HYPH
cord-001734-bbeznd3r	358	70	strand	strand	NN
cord-001734-bbeznd3r	358	71	RNA	RNA	NNP
cord-001734-bbeznd3r	358	72	virus	virus	NN
cord-001734-bbeznd3r	358	73	replication	replication	NN
cord-001734-bbeznd3r	358	74	factories	factory	NNS
cord-001734-bbeznd3r	359	1	Early	early	JJ
cord-001734-bbeznd3r	359	2	dengue	dengue	NN
cord-001734-bbeznd3r	359	3	virus	virus	NN
cord-001734-bbeznd3r	359	4	protein	protein	NN
cord-001734-bbeznd3r	359	5	synthesis	synthesis	NN
cord-001734-bbeznd3r	359	6	induces	induce	VBZ
cord-001734-bbeznd3r	359	7	extensive	extensive	JJ
cord-001734-bbeznd3r	359	8	rearrangement	rearrangement	NN
cord-001734-bbeznd3r	359	9	of	of	IN
cord-001734-bbeznd3r	359	10	the	the	DT
cord-001734-bbeznd3r	359	11	endoplasmic	endoplasmic	NN
cord-001734-bbeznd3r	359	12	reticulum	reticulum	NN
cord-001734-bbeznd3r	359	13	independent	independent	JJ
cord-001734-bbeznd3r	359	14	of	of	IN
cord-001734-bbeznd3r	359	15	the	the	DT
cord-001734-bbeznd3r	359	16	UPR	UPR	NNP
cord-001734-bbeznd3r	359	17	and	and	CC
cord-001734-bbeznd3r	359	18	SREBP-2	SREBP-2	NNP
cord-001734-bbeznd3r	359	19	pathway	pathway	NN
cord-001734-bbeznd3r	359	20	Elimination	Elimination	NNP
cord-001734-bbeznd3r	359	21	of	of	IN
cord-001734-bbeznd3r	359	22	the	the	DT
cord-001734-bbeznd3r	359	23	native	native	JJ
cord-001734-bbeznd3r	359	24	structure	structure	NN
cord-001734-bbeznd3r	359	25	and	and	CC
cord-001734-bbeznd3r	359	26	solubility	solubility	NN
cord-001734-bbeznd3r	359	27	of	of	IN
cord-001734-bbeznd3r	359	28	the	the	DT
cord-001734-bbeznd3r	359	29	hVAPB	hvapb	JJ
cord-001734-bbeznd3r	359	30	MSP	MSP	NNP
cord-001734-bbeznd3r	359	31	domain	domain	NN
cord-001734-bbeznd3r	359	32	by	by	IN
cord-001734-bbeznd3r	359	33	the	the	DT
cord-001734-bbeznd3r	359	34	Pro56Ser	Pro56Ser	NNP
cord-001734-bbeznd3r	359	35	mutation	mutation	NN
cord-001734-bbeznd3r	359	36	that	that	WDT
cord-001734-bbeznd3r	359	37	causes	cause	VBZ
cord-001734-bbeznd3r	359	38	amyotrophic	amyotrophic	JJ
cord-001734-bbeznd3r	359	39	lateral	lateral	JJ
cord-001734-bbeznd3r	359	40	sclerosis	sclerosis	NN
cord-001734-bbeznd3r	359	41	A	a	DT
cord-001734-bbeznd3r	359	42	VAPB	vapb	RB
cord-001734-bbeznd3r	359	43	mutant	mutant	NN
cord-001734-bbeznd3r	359	44	linked	link	VBN
cord-001734-bbeznd3r	359	45	to	to	IN
cord-001734-bbeznd3r	359	46	amyotrophic	amyotrophic	JJ
cord-001734-bbeznd3r	359	47	lateral	lateral	JJ
cord-001734-bbeznd3r	359	48	sclerosis	sclerosis	NN
cord-001734-bbeznd3r	359	49	generates	generate	VBZ
cord-001734-bbeznd3r	359	50	a	a	DT
cord-001734-bbeznd3r	359	51	novel	novel	JJ
cord-001734-bbeznd3r	359	52	form	form	NN
cord-001734-bbeznd3r	359	53	of	of	IN
cord-001734-bbeznd3r	359	54	organized	organized	JJ
cord-001734-bbeznd3r	359	55	smooth	smooth	JJ
cord-001734-bbeznd3r	359	56	endoplasmic	endoplasmic	NN
cord-001734-bbeznd3r	359	57	reticulum	reticulum	NN
cord-001734-bbeznd3r	359	58	Structured	structure	VBN
cord-001734-bbeznd3r	359	59	crowding	crowding	NN
cord-001734-bbeznd3r	359	60	and	and	CC
cord-001734-bbeznd3r	359	61	its	-PRON-	PRP$
cord-001734-bbeznd3r	359	62	effects	effect	NNS
cord-001734-bbeznd3r	359	63	on	on	IN
cord-001734-bbeznd3r	359	64	enzyme	enzyme	NN
cord-001734-bbeznd3r	359	65	catalysis	catalysis	NN
cord-001734-bbeznd3r	359	66	HIV-1	HIV-1	NNP
cord-001734-bbeznd3r	359	67	protease	protease	NN
cord-001734-bbeznd3r	359	68	folding	folding	NN
cord-001734-bbeznd3r	359	69	and	and	CC
cord-001734-bbeznd3r	359	70	the	the	DT
cord-001734-bbeznd3r	359	71	design	design	NN
cord-001734-bbeznd3r	359	72	of	of	IN
cord-001734-bbeznd3r	359	73	drugs	drug	NNS
cord-001734-bbeznd3r	359	74	which	which	WDT
cord-001734-bbeznd3r	359	75	do	do	VBP
cord-001734-bbeznd3r	359	76	not	not	RB
cord-001734-bbeznd3r	359	77	create	create	VB
cord-001734-bbeznd3r	359	78	resistance	resistance	NN
cord-001734-bbeznd3r	359	79	Novel	Novel	NNP
cord-001734-bbeznd3r	359	80	dengue	dengue	NN
cord-001734-bbeznd3r	359	81	virus	virus	NN
cord-001734-bbeznd3r	359	82	-	-	HYPH
cord-001734-bbeznd3r	359	83	specific	specific	JJ
cord-001734-bbeznd3r	359	84	NS2B	NS2B	NNP
cord-001734-bbeznd3r	359	85	/	/	SYM
cord-001734-bbeznd3r	359	86	NS3	ns3	RB
cord-001734-bbeznd3r	359	87	protease	protease	NN
cord-001734-bbeznd3r	359	88	inhibitor	inhibitor	NN
cord-001734-bbeznd3r	359	89	,	,	,
cord-001734-bbeznd3r	359	90	BP2109	BP2109	NNP
cord-001734-bbeznd3r	359	91	,	,	,
cord-001734-bbeznd3r	359	92	discovered	discover	VBN
cord-001734-bbeznd3r	359	93	by	by	IN
cord-001734-bbeznd3r	359	94	a	a	DT
cord-001734-bbeznd3r	359	95	high	high	JJ
cord-001734-bbeznd3r	359	96	-	-	HYPH
cord-001734-bbeznd3r	359	97	throughput	throughput	NN
cord-001734-bbeznd3r	359	98	screening	screening	NN
cord-001734-bbeznd3r	359	99	assay	assay	NN
cord-001734-bbeznd3r	359	100	.	.	.
cord-001734-bbeznd3r	360	1	Antimicrob	Antimicrob	NNP
cord-001734-bbeznd3r	360	2	Agents	Agents	NNPS
cord-001734-bbeznd3r	360	3	Chemother	Chemother	NNP
cord-001734-bbeznd3r	361	1	A	a	DT
cord-001734-bbeznd3r	361	2	small	small	JJ
cord-001734-bbeznd3r	361	3	compound	compound	NN
cord-001734-bbeznd3r	361	4	targeting	target	VBG
cord-001734-bbeznd3r	361	5	the	the	DT
cord-001734-bbeznd3r	361	6	interaction	interaction	NN
cord-001734-bbeznd3r	361	7	between	between	IN
cord-001734-bbeznd3r	361	8	nonstructural	nonstructural	JJ
cord-001734-bbeznd3r	361	9	proteins	protein	NNS
cord-001734-bbeznd3r	361	10	2B	2b	CD
cord-001734-bbeznd3r	361	11	and	and	CC
cord-001734-bbeznd3r	361	12	3	3	CD
cord-001734-bbeznd3r	361	13	inhibits	inhibit	VBZ
cord-001734-bbeznd3r	361	14	dengue	dengue	NN
cord-001734-bbeznd3r	361	15	virus	virus	NN
cord-001734-bbeznd3r	361	16	replication	replication	NN