id sid tid token lemma pos cord-001446-mpuovmeb 1 1 key key JJ cord-001446-mpuovmeb 1 2 : : : cord-001446-mpuovmeb 1 3 cord-001446-mpuovmeb cord-001446-mpuovmeb . cord-001446-mpuovmeb 2 1 authors author NNS cord-001446-mpuovmeb 2 2 : : : cord-001446-mpuovmeb 2 3 Bratcher Bratcher NNP cord-001446-mpuovmeb 2 4 , , , cord-001446-mpuovmeb 2 5 Preston Preston NNP cord-001446-mpuovmeb 2 6 E. E. NNP cord-001446-mpuovmeb 2 7 ; ; : cord-001446-mpuovmeb 2 8 Gaggar Gaggar NNP cord-001446-mpuovmeb 2 9 , , , cord-001446-mpuovmeb 2 10 Amit Amit NNP cord-001446-mpuovmeb 2 11 title title NN cord-001446-mpuovmeb 2 12 : : : cord-001446-mpuovmeb 3 1 Factors factor NNS cord-001446-mpuovmeb 3 2 Influencing influence VBG cord-001446-mpuovmeb 3 3 the the DT cord-001446-mpuovmeb 3 4 Measurement Measurement NNP cord-001446-mpuovmeb 3 5 of of IN cord-001446-mpuovmeb 3 6 Plasma Plasma NNP cord-001446-mpuovmeb 3 7 / / SYM cord-001446-mpuovmeb 3 8 Serum Serum NNP cord-001446-mpuovmeb 3 9 Surfactant Surfactant NNP cord-001446-mpuovmeb 3 10 Protein Protein NNP cord-001446-mpuovmeb 3 11 D D NNP cord-001446-mpuovmeb 3 12 Levels Levels NNP cord-001446-mpuovmeb 3 13 by by IN cord-001446-mpuovmeb 3 14 ELISA ELISA NNP cord-001446-mpuovmeb 3 15 date date NN cord-001446-mpuovmeb 3 16 : : : cord-001446-mpuovmeb 3 17 2014 2014 CD cord-001446-mpuovmeb 3 18 - - HYPH cord-001446-mpuovmeb 3 19 11 11 CD cord-001446-mpuovmeb 3 20 - - HYPH cord-001446-mpuovmeb 3 21 03 03 CD cord-001446-mpuovmeb 3 22 journal journal NN cord-001446-mpuovmeb 3 23 : : : cord-001446-mpuovmeb 4 1 PLoS PLoS NNP cord-001446-mpuovmeb 4 2 One one CD cord-001446-mpuovmeb 4 3 DOI DOI NNP cord-001446-mpuovmeb 4 4 : : : cord-001446-mpuovmeb 4 5 10.1371 10.1371 CD cord-001446-mpuovmeb 4 6 / / SYM cord-001446-mpuovmeb 4 7 journal.pone.0111466 journal.pone.0111466 NNP cord-001446-mpuovmeb 4 8 sha sha NNP cord-001446-mpuovmeb 4 9 : : : cord-001446-mpuovmeb 4 10 dc4332792ad6c643b1142cef1d344755a64b9625 dc4332792ad6c643b1142cef1d344755a64b9625 VB cord-001446-mpuovmeb 4 11 doc_id doc_id CD cord-001446-mpuovmeb 4 12 : : : cord-001446-mpuovmeb 4 13 1446 1446 CD cord-001446-mpuovmeb 4 14 cord_uid cord_uid NNS cord-001446-mpuovmeb 4 15 : : : cord-001446-mpuovmeb 4 16 mpuovmeb mpuovmeb NNP cord-001446-mpuovmeb 4 17 BACKGROUND BACKGROUND NNP cord-001446-mpuovmeb 4 18 : : : cord-001446-mpuovmeb 5 1 Extensive extensive JJ cord-001446-mpuovmeb 5 2 variations variation NNS cord-001446-mpuovmeb 5 3 in in IN cord-001446-mpuovmeb 5 4 human human JJ cord-001446-mpuovmeb 5 5 surfactant surfactant NN cord-001446-mpuovmeb 5 6 protein protein NN cord-001446-mpuovmeb 5 7 D D NNP cord-001446-mpuovmeb 5 8 ( ( -LRB- cord-001446-mpuovmeb 5 9 SP SP NNP cord-001446-mpuovmeb 5 10 - - HYPH cord-001446-mpuovmeb 5 11 D D NNP cord-001446-mpuovmeb 5 12 ) ) -RRB- cord-001446-mpuovmeb 5 13 levels level NNS cord-001446-mpuovmeb 5 14 in in IN cord-001446-mpuovmeb 5 15 circulation circulation NN cord-001446-mpuovmeb 5 16 as as IN cord-001446-mpuovmeb 5 17 measured measure VBN cord-001446-mpuovmeb 5 18 by by IN cord-001446-mpuovmeb 5 19 ELISA ELISA NNP cord-001446-mpuovmeb 5 20 exist exist VBP cord-001446-mpuovmeb 5 21 in in IN cord-001446-mpuovmeb 5 22 the the DT cord-001446-mpuovmeb 5 23 published publish VBN cord-001446-mpuovmeb 5 24 literature literature NN cord-001446-mpuovmeb 5 25 . . . cord-001446-mpuovmeb 6 1 In in IN cord-001446-mpuovmeb 6 2 order order NN cord-001446-mpuovmeb 6 3 to to TO cord-001446-mpuovmeb 6 4 determine determine VB cord-001446-mpuovmeb 6 5 the the DT cord-001446-mpuovmeb 6 6 source source NN cord-001446-mpuovmeb 6 7 of of IN cord-001446-mpuovmeb 6 8 these these DT cord-001446-mpuovmeb 6 9 variations variation NNS cord-001446-mpuovmeb 6 10 , , , cord-001446-mpuovmeb 6 11 factors factor NNS cord-001446-mpuovmeb 6 12 influencing influence VBG cord-001446-mpuovmeb 6 13 the the DT cord-001446-mpuovmeb 6 14 measurement measurement NN cord-001446-mpuovmeb 6 15 by by IN cord-001446-mpuovmeb 6 16 ELISA ELISA NNP cord-001446-mpuovmeb 6 17 were be VBD cord-001446-mpuovmeb 6 18 explored explore VBN cord-001446-mpuovmeb 6 19 . . . cord-001446-mpuovmeb 7 1 MATERIALS materials NN cord-001446-mpuovmeb 7 2 AND and CC cord-001446-mpuovmeb 7 3 METHODS method NNS cord-001446-mpuovmeb 7 4 : : : cord-001446-mpuovmeb 7 5 Peripheral peripheral JJ cord-001446-mpuovmeb 7 6 blood blood NN cord-001446-mpuovmeb 7 7 from from IN cord-001446-mpuovmeb 7 8 healthy healthy JJ cord-001446-mpuovmeb 7 9 individuals individual NNS cord-001446-mpuovmeb 7 10 was be VBD cord-001446-mpuovmeb 7 11 collected collect VBN cord-001446-mpuovmeb 7 12 into into IN cord-001446-mpuovmeb 7 13 various various JJ cord-001446-mpuovmeb 7 14 vacutainers vacutainer NNS cord-001446-mpuovmeb 7 15 during during IN cord-001446-mpuovmeb 7 16 the the DT cord-001446-mpuovmeb 7 17 same same JJ cord-001446-mpuovmeb 7 18 blood blood NN cord-001446-mpuovmeb 7 19 draw draw NN cord-001446-mpuovmeb 7 20 . . . cord-001446-mpuovmeb 8 1 Recombinant recombinant JJ cord-001446-mpuovmeb 8 2 SP SP NNP cord-001446-mpuovmeb 8 3 - - HYPH cord-001446-mpuovmeb 8 4 D D NNP cord-001446-mpuovmeb 8 5 was be VBD cord-001446-mpuovmeb 8 6 diluted dilute VBN cord-001446-mpuovmeb 8 7 into into IN cord-001446-mpuovmeb 8 8 different different JJ cord-001446-mpuovmeb 8 9 matrices matrix NNS cord-001446-mpuovmeb 8 10 and and CC cord-001446-mpuovmeb 8 11 used use VBN cord-001446-mpuovmeb 8 12 for for IN cord-001446-mpuovmeb 8 13 a a DT cord-001446-mpuovmeb 8 14 standard standard JJ cord-001446-mpuovmeb 8 15 curve curve NN cord-001446-mpuovmeb 8 16 . . . cord-001446-mpuovmeb 9 1 Samples sample NNS cord-001446-mpuovmeb 9 2 were be VBD cord-001446-mpuovmeb 9 3 analyzed analyze VBN cord-001446-mpuovmeb 9 4 by by IN cord-001446-mpuovmeb 9 5 capture capture NN cord-001446-mpuovmeb 9 6 ELISA ELISA NNP cord-001446-mpuovmeb 9 7 using use VBG cord-001446-mpuovmeb 9 8 one one CD cord-001446-mpuovmeb 9 9 of of IN cord-001446-mpuovmeb 9 10 two two CD cord-001446-mpuovmeb 9 11 distinct distinct JJ cord-001446-mpuovmeb 9 12 detection detection NN cord-001446-mpuovmeb 9 13 antibodies antibody NNS cord-001446-mpuovmeb 9 14 . . . cord-001446-mpuovmeb 10 1 RESULTS result NNS cord-001446-mpuovmeb 10 2 : : : cord-001446-mpuovmeb 11 1 The the DT cord-001446-mpuovmeb 11 2 type type NN cord-001446-mpuovmeb 11 3 of of IN cord-001446-mpuovmeb 11 4 matrix matrix NN cord-001446-mpuovmeb 11 5 had have VBD cord-001446-mpuovmeb 11 6 some some DT cord-001446-mpuovmeb 11 7 effects effect NNS cord-001446-mpuovmeb 11 8 on on IN cord-001446-mpuovmeb 11 9 detection detection NN cord-001446-mpuovmeb 11 10 of of IN cord-001446-mpuovmeb 11 11 recombinant recombinant JJ cord-001446-mpuovmeb 11 12 SP SP NNP cord-001446-mpuovmeb 11 13 - - HYPH cord-001446-mpuovmeb 11 14 D. D. NNP cord-001446-mpuovmeb 12 1 The the DT cord-001446-mpuovmeb 12 2 type type NN cord-001446-mpuovmeb 12 3 of of IN cord-001446-mpuovmeb 12 4 anticoagulant anticoagulant NN cord-001446-mpuovmeb 12 5 used use VBN cord-001446-mpuovmeb 12 6 and and CC cord-001446-mpuovmeb 12 7 dilution dilution NN cord-001446-mpuovmeb 12 8 factor factor NN cord-001446-mpuovmeb 12 9 had have VBD cord-001446-mpuovmeb 12 10 very very RB cord-001446-mpuovmeb 12 11 little little JJ cord-001446-mpuovmeb 12 12 effect effect NN cord-001446-mpuovmeb 12 13 , , , cord-001446-mpuovmeb 12 14 except except IN cord-001446-mpuovmeb 12 15 for for IN cord-001446-mpuovmeb 12 16 in in IN cord-001446-mpuovmeb 12 17 plasma plasma NN cord-001446-mpuovmeb 12 18 collected collect VBN cord-001446-mpuovmeb 12 19 in in IN cord-001446-mpuovmeb 12 20 EDTA EDTA NNP cord-001446-mpuovmeb 12 21 vacutainers vacutainer NNS cord-001446-mpuovmeb 12 22 . . . cord-001446-mpuovmeb 13 1 The the DT cord-001446-mpuovmeb 13 2 extent extent NN cord-001446-mpuovmeb 13 3 of of IN cord-001446-mpuovmeb 13 4 variation variation NN cord-001446-mpuovmeb 13 5 in in IN cord-001446-mpuovmeb 13 6 published publish VBN cord-001446-mpuovmeb 13 7 values value NNS cord-001446-mpuovmeb 13 8 seemed seem VBD cord-001446-mpuovmeb 13 9 to to TO cord-001446-mpuovmeb 13 10 be be VB cord-001446-mpuovmeb 13 11 due due JJ cord-001446-mpuovmeb 13 12 to to IN cord-001446-mpuovmeb 13 13 the the DT cord-001446-mpuovmeb 13 14 ELISA ELISA NNP cord-001446-mpuovmeb 13 15 configuration configuration NN cord-001446-mpuovmeb 13 16 employed employ VBN cord-001446-mpuovmeb 13 17 , , , cord-001446-mpuovmeb 13 18 and and CC cord-001446-mpuovmeb 13 19 , , , cord-001446-mpuovmeb 13 20 in in IN cord-001446-mpuovmeb 13 21 agreement agreement NN cord-001446-mpuovmeb 13 22 with with IN cord-001446-mpuovmeb 13 23 this this DT cord-001446-mpuovmeb 13 24 , , , cord-001446-mpuovmeb 13 25 we -PRON- PRP cord-001446-mpuovmeb 13 26 found find VBD cord-001446-mpuovmeb 13 27 that that IN cord-001446-mpuovmeb 13 28 by by IN cord-001446-mpuovmeb 13 29 switching switch VBG cord-001446-mpuovmeb 13 30 the the DT cord-001446-mpuovmeb 13 31 detection detection NN cord-001446-mpuovmeb 13 32 antibody antibody NN cord-001446-mpuovmeb 13 33 , , , cord-001446-mpuovmeb 13 34 there there EX cord-001446-mpuovmeb 13 35 was be VBD cord-001446-mpuovmeb 13 36 a a DT cord-001446-mpuovmeb 13 37 50 50 CD cord-001446-mpuovmeb 13 38 % % NN cord-001446-mpuovmeb 13 39 decrease decrease NN cord-001446-mpuovmeb 13 40 in in IN cord-001446-mpuovmeb 13 41 the the DT cord-001446-mpuovmeb 13 42 extrapolated extrapolate VBN cord-001446-mpuovmeb 13 43 SP SP NNP cord-001446-mpuovmeb 13 44 - - HYPH cord-001446-mpuovmeb 13 45 D d JJ cord-001446-mpuovmeb 13 46 value value NN cord-001446-mpuovmeb 13 47 of of IN cord-001446-mpuovmeb 13 48 serum serum NN cord-001446-mpuovmeb 13 49 and and CC cord-001446-mpuovmeb 13 50 plasma plasma NN cord-001446-mpuovmeb 13 51 samples sample NNS cord-001446-mpuovmeb 13 52 . . . cord-001446-mpuovmeb 14 1 Storage storage NN cord-001446-mpuovmeb 14 2 of of IN cord-001446-mpuovmeb 14 3 samples sample NNS cord-001446-mpuovmeb 14 4 resulted result VBN cord-001446-mpuovmeb 14 5 in in IN cord-001446-mpuovmeb 14 6 slight slight JJ cord-001446-mpuovmeb 14 7 changes change NNS cord-001446-mpuovmeb 14 8 in in IN cord-001446-mpuovmeb 14 9 measured measure VBN cord-001446-mpuovmeb 14 10 SP SP NNP cord-001446-mpuovmeb 14 11 - - HYPH cord-001446-mpuovmeb 14 12 D d JJ cord-001446-mpuovmeb 14 13 levels level NNS cord-001446-mpuovmeb 14 14 . . . cord-001446-mpuovmeb 15 1 CONCLUSIONS conclusion NNS cord-001446-mpuovmeb 15 2 : : : cord-001446-mpuovmeb 16 1 The the DT cord-001446-mpuovmeb 16 2 ELISA ELISA NNP cord-001446-mpuovmeb 16 3 configuration configuration NN cord-001446-mpuovmeb 16 4 employed employ VBN cord-001446-mpuovmeb 16 5 to to TO cord-001446-mpuovmeb 16 6 measure measure VB cord-001446-mpuovmeb 16 7 circulating circulate VBG cord-001446-mpuovmeb 16 8 levels level NNS cord-001446-mpuovmeb 16 9 of of IN cord-001446-mpuovmeb 16 10 SP SP NNP cord-001446-mpuovmeb 16 11 - - HYPH cord-001446-mpuovmeb 16 12 D D NNP cord-001446-mpuovmeb 16 13 has have VBZ cord-001446-mpuovmeb 16 14 a a DT cord-001446-mpuovmeb 16 15 significant significant JJ cord-001446-mpuovmeb 16 16 effect effect NN cord-001446-mpuovmeb 16 17 on on IN cord-001446-mpuovmeb 16 18 the the DT cord-001446-mpuovmeb 16 19 extrapolated extrapolate VBN cord-001446-mpuovmeb 16 20 values value NNS cord-001446-mpuovmeb 16 21 . . . cord-001446-mpuovmeb 17 1 In in IN cord-001446-mpuovmeb 17 2 both both DT cord-001446-mpuovmeb 17 3 configurations configuration NNS cord-001446-mpuovmeb 17 4 tested test VBN cord-001446-mpuovmeb 17 5 , , , cord-001446-mpuovmeb 17 6 the the DT cord-001446-mpuovmeb 17 7 use use NN cord-001446-mpuovmeb 17 8 of of IN cord-001446-mpuovmeb 17 9 EDTA EDTA NNP cord-001446-mpuovmeb 17 10 as as IN cord-001446-mpuovmeb 17 11 a a DT cord-001446-mpuovmeb 17 12 coagulant coagulant NN cord-001446-mpuovmeb 17 13 resulted result VBD cord-001446-mpuovmeb 17 14 in in IN cord-001446-mpuovmeb 17 15 inconsistent inconsistent JJ cord-001446-mpuovmeb 17 16 values value NNS cord-001446-mpuovmeb 17 17 , , , cord-001446-mpuovmeb 17 18 and and CC cord-001446-mpuovmeb 17 19 we -PRON- PRP cord-001446-mpuovmeb 17 20 , , , cord-001446-mpuovmeb 17 21 therefore therefore RB cord-001446-mpuovmeb 17 22 , , , cord-001446-mpuovmeb 17 23 suggest suggest VBP cord-001446-mpuovmeb 17 24 the the DT cord-001446-mpuovmeb 17 25 avoidance avoidance NN cord-001446-mpuovmeb 17 26 of of IN cord-001446-mpuovmeb 17 27 this this DT cord-001446-mpuovmeb 17 28 anticoagulant anticoagulant NN cord-001446-mpuovmeb 17 29 when when WRB cord-001446-mpuovmeb 17 30 assaying assay VBG cord-001446-mpuovmeb 17 31 for for IN cord-001446-mpuovmeb 17 32 SP SP NNP cord-001446-mpuovmeb 17 33 - - HYPH cord-001446-mpuovmeb 17 34 D D NNP cord-001446-mpuovmeb 17 35 by by IN cord-001446-mpuovmeb 17 36 ELISA ELISA NNP cord-001446-mpuovmeb 17 37 . . . cord-001446-mpuovmeb 18 1 While while IN cord-001446-mpuovmeb 18 2 the the DT cord-001446-mpuovmeb 18 3 demonstrated demonstrate VBN cord-001446-mpuovmeb 18 4 effects effect NNS cord-001446-mpuovmeb 18 5 of of IN cord-001446-mpuovmeb 18 6 several several JJ cord-001446-mpuovmeb 18 7 factors factor NNS cord-001446-mpuovmeb 18 8 on on IN cord-001446-mpuovmeb 18 9 measurement measurement NN cord-001446-mpuovmeb 18 10 of of IN cord-001446-mpuovmeb 18 11 SP SP NNP cord-001446-mpuovmeb 18 12 - - HYPH cord-001446-mpuovmeb 18 13 D D NNP cord-001446-mpuovmeb 18 14 may may MD cord-001446-mpuovmeb 18 15 not not RB cord-001446-mpuovmeb 18 16 account account VB cord-001446-mpuovmeb 18 17 for for IN cord-001446-mpuovmeb 18 18 all all PDT cord-001446-mpuovmeb 18 19 the the DT cord-001446-mpuovmeb 18 20 disparities disparity NNS cord-001446-mpuovmeb 18 21 amongst amongst IN cord-001446-mpuovmeb 18 22 the the DT cord-001446-mpuovmeb 18 23 previous previous JJ cord-001446-mpuovmeb 18 24 studies study NNS cord-001446-mpuovmeb 18 25 , , , cord-001446-mpuovmeb 18 26 they -PRON- PRP cord-001446-mpuovmeb 18 27 stress stress VBP cord-001446-mpuovmeb 18 28 that that IN cord-001446-mpuovmeb 18 29 variations variation NNS cord-001446-mpuovmeb 18 30 in in IN cord-001446-mpuovmeb 18 31 methodologies methodology NNS cord-001446-mpuovmeb 18 32 for for IN cord-001446-mpuovmeb 18 33 measuring measure VBG cord-001446-mpuovmeb 18 34 the the DT cord-001446-mpuovmeb 18 35 same same JJ cord-001446-mpuovmeb 18 36 protein protein NN cord-001446-mpuovmeb 18 37 can can MD cord-001446-mpuovmeb 18 38 result result VB cord-001446-mpuovmeb 18 39 in in IN cord-001446-mpuovmeb 18 40 very very RB cord-001446-mpuovmeb 18 41 inconsistent inconsistent JJ cord-001446-mpuovmeb 18 42 results result NNS cord-001446-mpuovmeb 18 43 . . . cord-001446-mpuovmeb 19 1 Surfactant surfactant NN cord-001446-mpuovmeb 19 2 protein protein NN cord-001446-mpuovmeb 19 3 D d NN cord-001446-mpuovmeb 19 4 ( ( -LRB- cord-001446-mpuovmeb 19 5 SP SP NNP cord-001446-mpuovmeb 19 6 - - HYPH cord-001446-mpuovmeb 19 7 D D NNP cord-001446-mpuovmeb 19 8 ) ) -RRB- cord-001446-mpuovmeb 19 9 is be VBZ cord-001446-mpuovmeb 19 10 a a DT cord-001446-mpuovmeb 19 11 pulmonary pulmonary JJ cord-001446-mpuovmeb 19 12 collectin collectin NN cord-001446-mpuovmeb 19 13 involved involve VBN cord-001446-mpuovmeb 19 14 in in IN cord-001446-mpuovmeb 19 15 regulation regulation NN cord-001446-mpuovmeb 19 16 of of IN cord-001446-mpuovmeb 19 17 inflammation inflammation NN cord-001446-mpuovmeb 19 18 , , , cord-001446-mpuovmeb 19 19 innate innate JJ cord-001446-mpuovmeb 19 20 immune immune JJ cord-001446-mpuovmeb 19 21 defense defense NN cord-001446-mpuovmeb 19 22 , , , cord-001446-mpuovmeb 19 23 and and CC cord-001446-mpuovmeb 19 24 surfactant surfactant NN cord-001446-mpuovmeb 19 25 homeostasis homeostasis NN cord-001446-mpuovmeb 19 26 . . . cord-001446-mpuovmeb 20 1 It -PRON- PRP cord-001446-mpuovmeb 20 2 is be VBZ cord-001446-mpuovmeb 20 3 expressed express VBN cord-001446-mpuovmeb 20 4 by by IN cord-001446-mpuovmeb 20 5 Clara Clara NNP cord-001446-mpuovmeb 20 6 cells cell NNS cord-001446-mpuovmeb 20 7 and and CC cord-001446-mpuovmeb 20 8 alveolar alveolar NN cord-001446-mpuovmeb 20 9 type type NN cord-001446-mpuovmeb 20 10 II ii CD cord-001446-mpuovmeb 20 11 cells cell NNS cord-001446-mpuovmeb 20 12 in in IN cord-001446-mpuovmeb 20 13 the the DT cord-001446-mpuovmeb 20 14 lung lung NN cord-001446-mpuovmeb 20 15 . . . cord-001446-mpuovmeb 21 1 SP SP NNP cord-001446-mpuovmeb 21 2 - - HYPH cord-001446-mpuovmeb 21 3 D D NNP cord-001446-mpuovmeb 21 4 has have VBZ cord-001446-mpuovmeb 21 5 a a DT cord-001446-mpuovmeb 21 6 multimeric multimeric JJ cord-001446-mpuovmeb 21 7 structure structure NN cord-001446-mpuovmeb 21 8 which which WDT cord-001446-mpuovmeb 21 9 gives give VBZ cord-001446-mpuovmeb 21 10 it -PRON- PRP cord-001446-mpuovmeb 21 11 the the DT cord-001446-mpuovmeb 21 12 ability ability NN cord-001446-mpuovmeb 21 13 to to TO cord-001446-mpuovmeb 21 14 agglutinate agglutinate VB cord-001446-mpuovmeb 21 15 pathogens pathogen NNS cord-001446-mpuovmeb 21 16 , , , cord-001446-mpuovmeb 21 17 as as RB cord-001446-mpuovmeb 21 18 well well RB cord-001446-mpuovmeb 21 19 as as IN cord-001446-mpuovmeb 21 20 aid aid NN cord-001446-mpuovmeb 21 21 in in IN cord-001446-mpuovmeb 21 22 the the DT cord-001446-mpuovmeb 21 23 clearance clearance NN cord-001446-mpuovmeb 21 24 of of IN cord-001446-mpuovmeb 21 25 apoptotic apoptotic JJ cord-001446-mpuovmeb 21 26 cells cell NNS cord-001446-mpuovmeb 21 27 , , , cord-001446-mpuovmeb 21 28 cellular cellular JJ cord-001446-mpuovmeb 21 29 debris debris NN cord-001446-mpuovmeb 21 30 , , , cord-001446-mpuovmeb 21 31 and and CC cord-001446-mpuovmeb 21 32 foreign foreign JJ cord-001446-mpuovmeb 21 33 particles particle NNS cord-001446-mpuovmeb 21 34 in in IN cord-001446-mpuovmeb 21 35 the the DT cord-001446-mpuovmeb 21 36 lung lung NN cord-001446-mpuovmeb 21 37 [ [ -LRB- cord-001446-mpuovmeb 21 38 reviewed review VBN cord-001446-mpuovmeb 21 39 in in IN cord-001446-mpuovmeb 21 40 [ [ -LRB- cord-001446-mpuovmeb 21 41 1 1 CD cord-001446-mpuovmeb 21 42 ] ] -RRB- cord-001446-mpuovmeb 21 43 ] ] -RRB- cord-001446-mpuovmeb 21 44 . . . cord-001446-mpuovmeb 22 1 Circulating circulate VBG cord-001446-mpuovmeb 22 2 levels level NNS cord-001446-mpuovmeb 22 3 of of IN cord-001446-mpuovmeb 22 4 SP SP NNP cord-001446-mpuovmeb 22 5 - - HYPH cord-001446-mpuovmeb 22 6 D D NNP cord-001446-mpuovmeb 22 7 have have VBP cord-001446-mpuovmeb 22 8 been be VBN cord-001446-mpuovmeb 22 9 examined examine VBN cord-001446-mpuovmeb 22 10 for for IN cord-001446-mpuovmeb 22 11 their -PRON- PRP$ cord-001446-mpuovmeb 22 12 potential potential JJ cord-001446-mpuovmeb 22 13 use use NN cord-001446-mpuovmeb 22 14 as as IN cord-001446-mpuovmeb 22 15 a a DT cord-001446-mpuovmeb 22 16 biomarker biomarker NN cord-001446-mpuovmeb 22 17 in in IN cord-001446-mpuovmeb 22 18 various various JJ cord-001446-mpuovmeb 22 19 diseases disease NNS cord-001446-mpuovmeb 22 20 including include VBG cord-001446-mpuovmeb 22 21 dermatitis dermatitis NN cord-001446-mpuovmeb 22 22 [ [ -LRB- cord-001446-mpuovmeb 22 23 2 2 CD cord-001446-mpuovmeb 22 24 , , , cord-001446-mpuovmeb 22 25 3 3 CD cord-001446-mpuovmeb 22 26 ] ] -RRB- cord-001446-mpuovmeb 22 27 , , , cord-001446-mpuovmeb 22 28 acute acute JJ cord-001446-mpuovmeb 22 29 lung lung NN cord-001446-mpuovmeb 22 30 injury injury NN cord-001446-mpuovmeb 22 31 ( ( -LRB- cord-001446-mpuovmeb 22 32 ALI)/acute ali)/acute JJ cord-001446-mpuovmeb 22 33 respiratory respiratory JJ cord-001446-mpuovmeb 22 34 distress distress NN cord-001446-mpuovmeb 22 35 syndrome syndrome NN cord-001446-mpuovmeb 22 36 ( ( -LRB- cord-001446-mpuovmeb 22 37 ARDS ARDS NNP cord-001446-mpuovmeb 22 38 ) ) -RRB- cord-001446-mpuovmeb 22 39 [ [ -LRB- cord-001446-mpuovmeb 22 40 4 4 LS cord-001446-mpuovmeb 22 41 ] ] -RRB- cord-001446-mpuovmeb 22 42 [ [ -LRB- cord-001446-mpuovmeb 22 43 5 5 CD cord-001446-mpuovmeb 22 44 ] ] -RRB- cord-001446-mpuovmeb 22 45 [ [ -LRB- cord-001446-mpuovmeb 22 46 6 6 CD cord-001446-mpuovmeb 22 47 ] ] -RRB- cord-001446-mpuovmeb 22 48 [ [ -LRB- cord-001446-mpuovmeb 22 49 7 7 CD cord-001446-mpuovmeb 22 50 ] ] -RRB- cord-001446-mpuovmeb 22 51 [ [ -LRB- cord-001446-mpuovmeb 22 52 8 8 CD cord-001446-mpuovmeb 22 53 ] ] -RRB- cord-001446-mpuovmeb 22 54 [ [ -LRB- cord-001446-mpuovmeb 22 55 9 9 CD cord-001446-mpuovmeb 22 56 ] ] -RRB- cord-001446-mpuovmeb 22 57 [ [ -LRB- cord-001446-mpuovmeb 22 58 10 10 CD cord-001446-mpuovmeb 22 59 ] ] -RRB- cord-001446-mpuovmeb 22 60 [ [ -LRB- cord-001446-mpuovmeb 22 61 11 11 CD cord-001446-mpuovmeb 22 62 ] ] -RRB- cord-001446-mpuovmeb 22 63 [ [ -LRB- cord-001446-mpuovmeb 22 64 12 12 CD cord-001446-mpuovmeb 22 65 ] ] -RRB- cord-001446-mpuovmeb 22 66 [ [ -LRB- cord-001446-mpuovmeb 22 67 13 13 CD cord-001446-mpuovmeb 22 68 ] ] -RRB- cord-001446-mpuovmeb 22 69 , , , cord-001446-mpuovmeb 22 70 periodontitis periodontitis NN cord-001446-mpuovmeb 22 71 [ [ -LRB- cord-001446-mpuovmeb 22 72 14 14 CD cord-001446-mpuovmeb 22 73 ] ] -RRB- cord-001446-mpuovmeb 22 74 , , , cord-001446-mpuovmeb 22 75 interstitial interstitial JJ cord-001446-mpuovmeb 22 76 pulmonary pulmonary JJ cord-001446-mpuovmeb 22 77 fibrosis fibrosis NN cord-001446-mpuovmeb 22 78 ( ( -LRB- cord-001446-mpuovmeb 22 79 IPF IPF NNP cord-001446-mpuovmeb 22 80 ) ) -RRB- cord-001446-mpuovmeb 22 81 [ [ -LRB- cord-001446-mpuovmeb 22 82 10 10 CD cord-001446-mpuovmeb 22 83 , , , cord-001446-mpuovmeb 22 84 12 12 CD cord-001446-mpuovmeb 22 85 , , , cord-001446-mpuovmeb 22 86 [ [ -LRB- cord-001446-mpuovmeb 22 87 15 15 CD cord-001446-mpuovmeb 22 88 ] ] -RRB- cord-001446-mpuovmeb 22 89 [ [ -LRB- cord-001446-mpuovmeb 22 90 16 16 CD cord-001446-mpuovmeb 22 91 ] ] -RRB- cord-001446-mpuovmeb 22 92 [ [ -LRB- cord-001446-mpuovmeb 22 93 17 17 CD cord-001446-mpuovmeb 22 94 ] ] -RRB- cord-001446-mpuovmeb 22 95 [ [ -LRB- cord-001446-mpuovmeb 22 96 18 18 CD cord-001446-mpuovmeb 22 97 ] ] -RRB- cord-001446-mpuovmeb 22 98 [ [ -LRB- cord-001446-mpuovmeb 22 99 19 19 CD cord-001446-mpuovmeb 22 100 ] ] -RRB- cord-001446-mpuovmeb 22 101 [ [ -LRB- cord-001446-mpuovmeb 22 102 20 20 CD cord-001446-mpuovmeb 22 103 ] ] -RRB- cord-001446-mpuovmeb 22 104 [ [ -LRB- cord-001446-mpuovmeb 22 105 21 21 CD cord-001446-mpuovmeb 22 106 ] ] -RRB- cord-001446-mpuovmeb 22 107 [ [ -LRB- cord-001446-mpuovmeb 22 108 22 22 CD cord-001446-mpuovmeb 22 109 ] ] -RRB- cord-001446-mpuovmeb 22 110 [ [ -LRB- cord-001446-mpuovmeb 22 111 23 23 CD cord-001446-mpuovmeb 22 112 ] ] -RRB- cord-001446-mpuovmeb 22 113 , , , cord-001446-mpuovmeb 22 114 chronic chronic JJ cord-001446-mpuovmeb 22 115 obstructive obstructive JJ cord-001446-mpuovmeb 22 116 pulmonary pulmonary JJ cord-001446-mpuovmeb 22 117 disease disease NN cord-001446-mpuovmeb 22 118 ( ( -LRB- cord-001446-mpuovmeb 22 119 COPD COPD NNP cord-001446-mpuovmeb 22 120 ) ) -RRB- cord-001446-mpuovmeb 22 121 [ [ -LRB- cord-001446-mpuovmeb 22 122 15 15 CD cord-001446-mpuovmeb 22 123 , , , cord-001446-mpuovmeb 22 124 [ [ -LRB- cord-001446-mpuovmeb 22 125 24 24 CD cord-001446-mpuovmeb 22 126 ] ] -RRB- cord-001446-mpuovmeb 22 127 [ [ -LRB- cord-001446-mpuovmeb 22 128 25 25 CD cord-001446-mpuovmeb 22 129 ] ] -RRB- cord-001446-mpuovmeb 22 130 [ [ -LRB- cord-001446-mpuovmeb 22 131 26 26 CD cord-001446-mpuovmeb 22 132 ] ] -RRB- cord-001446-mpuovmeb 22 133 [ [ -LRB- cord-001446-mpuovmeb 22 134 27 27 CD cord-001446-mpuovmeb 22 135 ] ] -RRB- cord-001446-mpuovmeb 22 136 [ [ -LRB- cord-001446-mpuovmeb 22 137 28 28 CD cord-001446-mpuovmeb 22 138 ] ] -RRB- cord-001446-mpuovmeb 22 139 [ [ -LRB- cord-001446-mpuovmeb 22 140 29 29 CD cord-001446-mpuovmeb 22 141 ] ] -RRB- cord-001446-mpuovmeb 22 142 [ [ -LRB- cord-001446-mpuovmeb 22 143 30 30 CD cord-001446-mpuovmeb 22 144 ] ] -RRB- cord-001446-mpuovmeb 22 145 [ [ -LRB- cord-001446-mpuovmeb 22 146 31 31 CD cord-001446-mpuovmeb 22 147 ] ] -RRB- cord-001446-mpuovmeb 22 148 [ [ -LRB- cord-001446-mpuovmeb 22 149 32 32 CD cord-001446-mpuovmeb 22 150 ] ] -RRB- cord-001446-mpuovmeb 22 151 [ [ -LRB- cord-001446-mpuovmeb 22 152 33 33 CD cord-001446-mpuovmeb 22 153 ] ] -RRB- cord-001446-mpuovmeb 22 154 [ [ -LRB- cord-001446-mpuovmeb 22 155 34 34 CD cord-001446-mpuovmeb 22 156 ] ] -RRB- cord-001446-mpuovmeb 22 157 [ [ -LRB- cord-001446-mpuovmeb 22 158 35 35 CD cord-001446-mpuovmeb 22 159 ] ] -RRB- cord-001446-mpuovmeb 22 160 [ [ -LRB- cord-001446-mpuovmeb 22 161 36 36 CD cord-001446-mpuovmeb 22 162 ] ] -RRB- cord-001446-mpuovmeb 22 163 , , , cord-001446-mpuovmeb 22 164 emphysema emphysema NN cord-001446-mpuovmeb 22 165 [ [ -LRB- cord-001446-mpuovmeb 22 166 37 37 CD cord-001446-mpuovmeb 22 167 ] ] -RRB- cord-001446-mpuovmeb 22 168 , , , cord-001446-mpuovmeb 22 169 cystic cystic JJ cord-001446-mpuovmeb 22 170 fibrosis fibrosis NN cord-001446-mpuovmeb 22 171 ( ( -LRB- cord-001446-mpuovmeb 22 172 CF CF NNP cord-001446-mpuovmeb 22 173 ) ) -RRB- cord-001446-mpuovmeb 22 174 [ [ -LRB- cord-001446-mpuovmeb 22 175 15 15 CD cord-001446-mpuovmeb 22 176 , , , cord-001446-mpuovmeb 22 177 38 38 CD cord-001446-mpuovmeb 22 178 , , , cord-001446-mpuovmeb 22 179 39 39 CD cord-001446-mpuovmeb 22 180 ] ] -RRB- cord-001446-mpuovmeb 22 181 , , , cord-001446-mpuovmeb 22 182 coronary coronary JJ cord-001446-mpuovmeb 22 183 disease disease NN cord-001446-mpuovmeb 22 184 [ [ -LRB- cord-001446-mpuovmeb 22 185 40 40 CD cord-001446-mpuovmeb 22 186 , , , cord-001446-mpuovmeb 22 187 41 41 CD cord-001446-mpuovmeb 22 188 ] ] -RRB- cord-001446-mpuovmeb 22 189 , , , cord-001446-mpuovmeb 22 190 sclerosis sclerosis NN cord-001446-mpuovmeb 22 191 [ [ -LRB- cord-001446-mpuovmeb 22 192 42 42 CD cord-001446-mpuovmeb 22 193 ] ] -RRB- cord-001446-mpuovmeb 22 194 [ [ -LRB- cord-001446-mpuovmeb 22 195 43 43 CD cord-001446-mpuovmeb 22 196 ] ] -RRB- cord-001446-mpuovmeb 22 197 [ [ -LRB- cord-001446-mpuovmeb 22 198 44 44 CD cord-001446-mpuovmeb 22 199 ] ] -RRB- cord-001446-mpuovmeb 22 200 [ [ -LRB- cord-001446-mpuovmeb 22 201 45 45 CD cord-001446-mpuovmeb 22 202 ] ] -RRB- cord-001446-mpuovmeb 22 203 [ [ -LRB- cord-001446-mpuovmeb 22 204 46 46 CD cord-001446-mpuovmeb 22 205 ] ] -RRB- cord-001446-mpuovmeb 22 206 , , , cord-001446-mpuovmeb 22 207 cancer cancer NN cord-001446-mpuovmeb 22 208 [ [ -LRB- cord-001446-mpuovmeb 22 209 47 47 CD cord-001446-mpuovmeb 22 210 , , , cord-001446-mpuovmeb 22 211 48 48 CD cord-001446-mpuovmeb 22 212 ] ] -RRB- cord-001446-mpuovmeb 22 213 , , , cord-001446-mpuovmeb 22 214 sarcoidosis sarcoidosi NNS cord-001446-mpuovmeb 22 215 [ [ -LRB- cord-001446-mpuovmeb 22 216 21 21 CD cord-001446-mpuovmeb 22 217 , , , cord-001446-mpuovmeb 22 218 49 49 CD cord-001446-mpuovmeb 22 219 ] ] -RRB- cord-001446-mpuovmeb 22 220 , , , cord-001446-mpuovmeb 22 221 allergies allergy NNS cord-001446-mpuovmeb 22 222 [ [ -LRB- cord-001446-mpuovmeb 22 223 28 28 CD cord-001446-mpuovmeb 22 224 , , , cord-001446-mpuovmeb 22 225 [ [ -LRB- cord-001446-mpuovmeb 22 226 50 50 CD cord-001446-mpuovmeb 22 227 ] ] -RRB- cord-001446-mpuovmeb 22 228 [ [ -LRB- cord-001446-mpuovmeb 22 229 51 51 CD cord-001446-mpuovmeb 22 230 ] ] -RRB- cord-001446-mpuovmeb 22 231 [ [ -LRB- cord-001446-mpuovmeb 22 232 52 52 CD cord-001446-mpuovmeb 22 233 ] ] -RRB- cord-001446-mpuovmeb 22 234 , , , cord-001446-mpuovmeb 22 235 rheumatoid rheumatoid NN cord-001446-mpuovmeb 22 236 arthritis arthritis NN cord-001446-mpuovmeb 22 237 [ [ -LRB- cord-001446-mpuovmeb 22 238 53 53 CD cord-001446-mpuovmeb 22 239 , , , cord-001446-mpuovmeb 22 240 54 54 CD cord-001446-mpuovmeb 22 241 ] ] -RRB- cord-001446-mpuovmeb 22 242 , , , cord-001446-mpuovmeb 22 243 and and CC cord-001446-mpuovmeb 22 244 respiratory respiratory JJ cord-001446-mpuovmeb 22 245 infections infection NNS cord-001446-mpuovmeb 22 246 [ [ -LRB- cord-001446-mpuovmeb 22 247 18 18 CD cord-001446-mpuovmeb 22 248 , , , cord-001446-mpuovmeb 22 249 [ [ -LRB- cord-001446-mpuovmeb 22 250 55 55 CD cord-001446-mpuovmeb 22 251 ] ] -RRB- cord-001446-mpuovmeb 22 252 [ [ -LRB- cord-001446-mpuovmeb 22 253 56 56 CD cord-001446-mpuovmeb 22 254 ] ] -RRB- cord-001446-mpuovmeb 22 255 [ [ -LRB- cord-001446-mpuovmeb 22 256 57 57 CD cord-001446-mpuovmeb 22 257 ] ] -RRB- cord-001446-mpuovmeb 22 258 [ [ -LRB- cord-001446-mpuovmeb 22 259 58 58 CD cord-001446-mpuovmeb 22 260 ] ] -RRB- cord-001446-mpuovmeb 22 261 [ [ -LRB- cord-001446-mpuovmeb 22 262 59 59 CD cord-001446-mpuovmeb 22 263 ] ] -RRB- cord-001446-mpuovmeb 22 264 [ [ -LRB- cord-001446-mpuovmeb 22 265 60 60 CD cord-001446-mpuovmeb 22 266 ] ] -RRB- cord-001446-mpuovmeb 22 267 . . . cord-001446-mpuovmeb 23 1 SP SP NNP cord-001446-mpuovmeb 23 2 - - HYPH cord-001446-mpuovmeb 23 3 D d JJ cord-001446-mpuovmeb 23 4 levels level NNS cord-001446-mpuovmeb 23 5 have have VBP cord-001446-mpuovmeb 23 6 also also RB cord-001446-mpuovmeb 23 7 been be VBN cord-001446-mpuovmeb 23 8 proposed propose VBN cord-001446-mpuovmeb 23 9 to to TO cord-001446-mpuovmeb 23 10 correlate correlate VB cord-001446-mpuovmeb 23 11 with with IN cord-001446-mpuovmeb 23 12 genetic genetic JJ cord-001446-mpuovmeb 23 13 elements element NNS cord-001446-mpuovmeb 23 14 [ [ -LRB- cord-001446-mpuovmeb 23 15 61 61 CD cord-001446-mpuovmeb 23 16 ] ] -RRB- cord-001446-mpuovmeb 23 17 [ [ -LRB- cord-001446-mpuovmeb 23 18 62 62 CD cord-001446-mpuovmeb 23 19 ] ] -RRB- cord-001446-mpuovmeb 24 1 [ [ -LRB- cord-001446-mpuovmeb 24 2 63 63 CD cord-001446-mpuovmeb 24 3 ] ] -RRB- cord-001446-mpuovmeb 24 4 , , , cord-001446-mpuovmeb 24 5 body body NN cord-001446-mpuovmeb 24 6 mass mass NN cord-001446-mpuovmeb 24 7 index index NN cord-001446-mpuovmeb 24 8 ( ( -LRB- cord-001446-mpuovmeb 24 9 BMI BMI NNP cord-001446-mpuovmeb 24 10 ) ) -RRB- cord-001446-mpuovmeb 24 11 [ [ -LRB- cord-001446-mpuovmeb 24 12 64 64 CD cord-001446-mpuovmeb 24 13 ] ] -RRB- cord-001446-mpuovmeb 24 14 [ [ -LRB- cord-001446-mpuovmeb 24 15 65 65 CD cord-001446-mpuovmeb 24 16 ] ] -RRB- cord-001446-mpuovmeb 24 17 [ [ -LRB- cord-001446-mpuovmeb 24 18 66 66 CD cord-001446-mpuovmeb 24 19 ] ] -RRB- cord-001446-mpuovmeb 24 20 [ [ -LRB- cord-001446-mpuovmeb 24 21 67 67 CD cord-001446-mpuovmeb 24 22 ] ] -RRB- cord-001446-mpuovmeb 24 23 [ [ -LRB- cord-001446-mpuovmeb 24 24 68 68 CD cord-001446-mpuovmeb 24 25 ] ] -RRB- cord-001446-mpuovmeb 24 26 , , , cord-001446-mpuovmeb 24 27 age age NN cord-001446-mpuovmeb 24 28 [ [ -LRB- cord-001446-mpuovmeb 24 29 65 65 CD cord-001446-mpuovmeb 24 30 ] ] -RRB- cord-001446-mpuovmeb 24 31 , , , cord-001446-mpuovmeb 24 32 circadian circadian JJ cord-001446-mpuovmeb 24 33 rhythm rhythm NN cord-001446-mpuovmeb 24 34 [ [ -LRB- cord-001446-mpuovmeb 24 35 69 69 CD cord-001446-mpuovmeb 24 36 ] ] -RRB- cord-001446-mpuovmeb 24 37 , , , cord-001446-mpuovmeb 24 38 and and CC cord-001446-mpuovmeb 24 39 with with IN cord-001446-mpuovmeb 24 40 particle particle NN cord-001446-mpuovmeb 24 41 exposure exposure NN cord-001446-mpuovmeb 24 42 [ [ -LRB- cord-001446-mpuovmeb 24 43 70 70 CD cord-001446-mpuovmeb 24 44 , , , cord-001446-mpuovmeb 24 45 71 71 CD cord-001446-mpuovmeb 24 46 ] ] -RRB- cord-001446-mpuovmeb 24 47 and and CC cord-001446-mpuovmeb 24 48 cigarette cigarette NN cord-001446-mpuovmeb 24 49 smoking smoking NN cord-001446-mpuovmeb 24 50 habits habit NNS cord-001446-mpuovmeb 24 51 [ [ -LRB- cord-001446-mpuovmeb 24 52 25 25 CD cord-001446-mpuovmeb 24 53 , , , cord-001446-mpuovmeb 24 54 27 27 CD cord-001446-mpuovmeb 24 55 , , , cord-001446-mpuovmeb 24 56 28 28 CD cord-001446-mpuovmeb 24 57 , , , cord-001446-mpuovmeb 24 58 31 31 CD cord-001446-mpuovmeb 24 59 , , , cord-001446-mpuovmeb 24 60 37 37 CD cord-001446-mpuovmeb 24 61 , , , cord-001446-mpuovmeb 24 62 [ [ -LRB- cord-001446-mpuovmeb 24 63 72 72 CD cord-001446-mpuovmeb 24 64 ] ] -RRB- cord-001446-mpuovmeb 24 65 [ [ -LRB- cord-001446-mpuovmeb 24 66 73 73 CD cord-001446-mpuovmeb 24 67 ] ] -RRB- cord-001446-mpuovmeb 24 68 [ [ -LRB- cord-001446-mpuovmeb 24 69 74 74 CD cord-001446-mpuovmeb 24 70 ] ] -RRB- cord-001446-mpuovmeb 24 71 [ [ -LRB- cord-001446-mpuovmeb 24 72 75 75 CD cord-001446-mpuovmeb 24 73 ] ] -RRB- cord-001446-mpuovmeb 24 74 [ [ -LRB- cord-001446-mpuovmeb 24 75 76 76 CD cord-001446-mpuovmeb 24 76 ] ] -RRB- cord-001446-mpuovmeb 24 77 [ [ -LRB- cord-001446-mpuovmeb 24 78 77 77 CD cord-001446-mpuovmeb 24 79 ] ] -RRB- cord-001446-mpuovmeb 24 80 . . . cord-001446-mpuovmeb 25 1 In in IN cord-001446-mpuovmeb 25 2 addition addition NN cord-001446-mpuovmeb 25 3 , , , cord-001446-mpuovmeb 25 4 there there EX cord-001446-mpuovmeb 25 5 have have VBP cord-001446-mpuovmeb 25 6 been be VBN cord-001446-mpuovmeb 25 7 studies study NNS cord-001446-mpuovmeb 25 8 examining examine VBG cord-001446-mpuovmeb 25 9 the the DT cord-001446-mpuovmeb 25 10 levels level NNS cord-001446-mpuovmeb 25 11 of of IN cord-001446-mpuovmeb 25 12 SP SP NNP cord-001446-mpuovmeb 25 13 - - HYPH cord-001446-mpuovmeb 25 14 D D NNP cord-001446-mpuovmeb 25 15 in in IN cord-001446-mpuovmeb 25 16 subjects subject NNS cord-001446-mpuovmeb 25 17 with with IN cord-001446-mpuovmeb 25 18 Turner Turner NNP cord-001446-mpuovmeb 25 19 syndrome syndrome NN cord-001446-mpuovmeb 25 20 [ [ -LRB- cord-001446-mpuovmeb 25 21 78 78 CD cord-001446-mpuovmeb 25 22 ] ] -RRB- cord-001446-mpuovmeb 25 23 , , , cord-001446-mpuovmeb 25 24 paraquat paraquat NN cord-001446-mpuovmeb 25 25 intoxication intoxication NN cord-001446-mpuovmeb 25 26 [ [ -LRB- cord-001446-mpuovmeb 25 27 79 79 CD cord-001446-mpuovmeb 25 28 ] ] -RRB- cord-001446-mpuovmeb 25 29 , , , cord-001446-mpuovmeb 25 30 swimming swim VBG cord-001446-mpuovmeb 25 31 in in IN cord-001446-mpuovmeb 25 32 variably variably RB cord-001446-mpuovmeb 25 33 treated treat VBN cord-001446-mpuovmeb 25 34 waters water NNS cord-001446-mpuovmeb 25 35 [ [ -LRB- cord-001446-mpuovmeb 25 36 80 80 CD cord-001446-mpuovmeb 25 37 ] ] -RRB- cord-001446-mpuovmeb 25 38 , , , cord-001446-mpuovmeb 25 39 lung lung NN cord-001446-mpuovmeb 25 40 transplant transplant NN cord-001446-mpuovmeb 25 41 patients patient NNS cord-001446-mpuovmeb 25 42 [ [ -LRB- cord-001446-mpuovmeb 25 43 81 81 CD cord-001446-mpuovmeb 25 44 ] ] -RRB- cord-001446-mpuovmeb 25 45 , , . cord-001446-mpuovmeb 26 1 patients patient NNS cord-001446-mpuovmeb 26 2 undergoing undergo VBG cord-001446-mpuovmeb 26 3 neurosurgical neurosurgical JJ cord-001446-mpuovmeb 26 4 operations operation NNS cord-001446-mpuovmeb 26 5 [ [ -LRB- cord-001446-mpuovmeb 26 6 82 82 CD cord-001446-mpuovmeb 26 7 ] ] -RRB- cord-001446-mpuovmeb 26 8 , , , cord-001446-mpuovmeb 26 9 drowning drown VBG cord-001446-mpuovmeb 26 10 victims victim NNS cord-001446-mpuovmeb 26 11 [ [ -LRB- cord-001446-mpuovmeb 26 12 83 83 CD cord-001446-mpuovmeb 26 13 ] ] -RRB- cord-001446-mpuovmeb 26 14 , , , cord-001446-mpuovmeb 26 15 polymyositis polymyositis NNP cord-001446-mpuovmeb 26 16 / / SYM cord-001446-mpuovmeb 26 17 dermatomyositis dermatomyositis NNP cord-001446-mpuovmeb 26 18 [ [ -LRB- cord-001446-mpuovmeb 26 19 84 84 CD cord-001446-mpuovmeb 26 20 ] ] -RRB- cord-001446-mpuovmeb 26 21 , , , cord-001446-mpuovmeb 26 22 dementia dementia NN cord-001446-mpuovmeb 26 23 [ [ -LRB- cord-001446-mpuovmeb 26 24 85 85 CD cord-001446-mpuovmeb 26 25 ] ] -RRB- cord-001446-mpuovmeb 26 26 , , , cord-001446-mpuovmeb 26 27 lupus lupus NN cord-001446-mpuovmeb 26 28 [ [ -LRB- cord-001446-mpuovmeb 26 29 86 86 CD cord-001446-mpuovmeb 26 30 ] ] -RRB- cord-001446-mpuovmeb 26 31 , , , cord-001446-mpuovmeb 26 32 and and CC cord-001446-mpuovmeb 26 33 sleep sleep NN cord-001446-mpuovmeb 26 34 apnea apnea NN cord-001446-mpuovmeb 26 35 [ [ -LRB- cord-001446-mpuovmeb 26 36 87 87 CD cord-001446-mpuovmeb 26 37 ] ] -RRB- cord-001446-mpuovmeb 26 38 . . . cord-001446-mpuovmeb 27 1 Similarly similarly RB cord-001446-mpuovmeb 27 2 to to IN cord-001446-mpuovmeb 27 3 CC-16 CC-16 NNP cord-001446-mpuovmeb 27 4 and and CC cord-001446-mpuovmeb 27 5 KL-6 KL-6 NNP cord-001446-mpuovmeb 27 6 , , , cord-001446-mpuovmeb 27 7 SP SP NNP cord-001446-mpuovmeb 27 8 - - HYPH cord-001446-mpuovmeb 27 9 D D NNP cord-001446-mpuovmeb 27 10 is be VBZ cord-001446-mpuovmeb 27 11 thought think VBN cord-001446-mpuovmeb 27 12 to to TO cord-001446-mpuovmeb 27 13 be be VB cord-001446-mpuovmeb 27 14 a a DT cord-001446-mpuovmeb 27 15 marker marker NN cord-001446-mpuovmeb 27 16 of of IN cord-001446-mpuovmeb 27 17 pulmonary pulmonary JJ cord-001446-mpuovmeb 27 18 leak leak NN cord-001446-mpuovmeb 27 19 into into IN cord-001446-mpuovmeb 27 20 the the DT cord-001446-mpuovmeb 27 21 vasculature vasculature NN cord-001446-mpuovmeb 27 22 [ [ -LRB- cord-001446-mpuovmeb 27 23 88 88 CD cord-001446-mpuovmeb 27 24 ] ] -RRB- cord-001446-mpuovmeb 27 25 , , , cord-001446-mpuovmeb 27 26 and and CC cord-001446-mpuovmeb 27 27 therefore therefore RB cord-001446-mpuovmeb 27 28 alveolar alveolar JJ cord-001446-mpuovmeb 27 29 destruction destruction NN cord-001446-mpuovmeb 27 30 would would MD cord-001446-mpuovmeb 27 31 result result VB cord-001446-mpuovmeb 27 32 in in IN cord-001446-mpuovmeb 27 33 an an DT cord-001446-mpuovmeb 27 34 increase increase NN cord-001446-mpuovmeb 27 35 in in IN cord-001446-mpuovmeb 27 36 levels level NNS cord-001446-mpuovmeb 27 37 of of IN cord-001446-mpuovmeb 27 38 these these DT cord-001446-mpuovmeb 27 39 pulmonary pulmonary JJ cord-001446-mpuovmeb 27 40 proteins protein NNS cord-001446-mpuovmeb 27 41 in in IN cord-001446-mpuovmeb 27 42 the the DT cord-001446-mpuovmeb 27 43 blood blood NN cord-001446-mpuovmeb 27 44 . . . cord-001446-mpuovmeb 28 1 However however RB cord-001446-mpuovmeb 28 2 , , , cord-001446-mpuovmeb 28 3 protein protein NN cord-001446-mpuovmeb 28 4 levels level NNS cord-001446-mpuovmeb 28 5 in in IN cord-001446-mpuovmeb 28 6 lung lung NN cord-001446-mpuovmeb 28 7 do do VBP cord-001446-mpuovmeb 28 8 not not RB cord-001446-mpuovmeb 28 9 always always RB cord-001446-mpuovmeb 28 10 correlate correlate VB cord-001446-mpuovmeb 28 11 with with IN cord-001446-mpuovmeb 28 12 protein protein NN cord-001446-mpuovmeb 28 13 levels level NNS cord-001446-mpuovmeb 28 14 in in IN cord-001446-mpuovmeb 28 15 blood blood NN cord-001446-mpuovmeb 28 16 [ [ -LRB- cord-001446-mpuovmeb 28 17 35 35 CD cord-001446-mpuovmeb 28 18 ] ] -RRB- cord-001446-mpuovmeb 28 19 , , , cord-001446-mpuovmeb 28 20 suggesting suggest VBG cord-001446-mpuovmeb 28 21 the the DT cord-001446-mpuovmeb 28 22 possibility possibility NN cord-001446-mpuovmeb 28 23 of of IN cord-001446-mpuovmeb 28 24 alternative alternative JJ cord-001446-mpuovmeb 28 25 mechanisms mechanism NNS cord-001446-mpuovmeb 28 26 affecting affect VBG cord-001446-mpuovmeb 28 27 SP SP NNP cord-001446-mpuovmeb 28 28 - - HYPH cord-001446-mpuovmeb 28 29 D d JJ cord-001446-mpuovmeb 28 30 levels level NNS cord-001446-mpuovmeb 28 31 in in IN cord-001446-mpuovmeb 28 32 circulation circulation NN cord-001446-mpuovmeb 28 33 . . . cord-001446-mpuovmeb 29 1 Various various JJ cord-001446-mpuovmeb 29 2 commercially commercially RB cord-001446-mpuovmeb 29 3 available available JJ cord-001446-mpuovmeb 29 4 kits kit NNS cord-001446-mpuovmeb 29 5 and and CC cord-001446-mpuovmeb 29 6 non non NNS cord-001446-mpuovmeb 29 7 - - JJ cord-001446-mpuovmeb 29 8 commercially commercially RB cord-001446-mpuovmeb 29 9 available available JJ cord-001446-mpuovmeb 29 10 ELISA ELISA NNP cord-001446-mpuovmeb 29 11 configurations configuration NNS cord-001446-mpuovmeb 29 12 have have VBP cord-001446-mpuovmeb 29 13 been be VBN cord-001446-mpuovmeb 29 14 used use VBN cord-001446-mpuovmeb 29 15 to to TO cord-001446-mpuovmeb 29 16 compare compare VB cord-001446-mpuovmeb 29 17 SP SP NNP cord-001446-mpuovmeb 29 18 - - HYPH cord-001446-mpuovmeb 29 19 D d JJ cord-001446-mpuovmeb 29 20 levels level NNS cord-001446-mpuovmeb 29 21 in in IN cord-001446-mpuovmeb 29 22 plasma plasma NN cord-001446-mpuovmeb 29 23 and and CC cord-001446-mpuovmeb 29 24 serum serum NN cord-001446-mpuovmeb 29 25 from from IN cord-001446-mpuovmeb 29 26 normal normal JJ cord-001446-mpuovmeb 29 27 , , , cord-001446-mpuovmeb 29 28 healthy healthy JJ cord-001446-mpuovmeb 29 29 controls control NNS cord-001446-mpuovmeb 29 30 and and CC cord-001446-mpuovmeb 29 31 the the DT cord-001446-mpuovmeb 29 32 various various JJ cord-001446-mpuovmeb 29 33 disease disease NN cord-001446-mpuovmeb 29 34 states state NNS cord-001446-mpuovmeb 29 35 described describe VBN cord-001446-mpuovmeb 29 36 above above RB cord-001446-mpuovmeb 29 37 . . . cord-001446-mpuovmeb 30 1 Interestingly interestingly RB cord-001446-mpuovmeb 30 2 , , , cord-001446-mpuovmeb 30 3 there there EX cord-001446-mpuovmeb 30 4 is be VBZ cord-001446-mpuovmeb 30 5 a a DT cord-001446-mpuovmeb 30 6 very very RB cord-001446-mpuovmeb 30 7 substantial substantial JJ cord-001446-mpuovmeb 30 8 discrepancy discrepancy NN cord-001446-mpuovmeb 30 9 between between IN cord-001446-mpuovmeb 30 10 the the DT cord-001446-mpuovmeb 30 11 reported report VBN cord-001446-mpuovmeb 30 12 values value NNS cord-001446-mpuovmeb 30 13 of of IN cord-001446-mpuovmeb 30 14 the the DT cord-001446-mpuovmeb 30 15 healthy healthy JJ cord-001446-mpuovmeb 30 16 control control NN cord-001446-mpuovmeb 30 17 populations population NNS cord-001446-mpuovmeb 30 18 between between IN cord-001446-mpuovmeb 30 19 studies study NNS cord-001446-mpuovmeb 30 20 , , , cord-001446-mpuovmeb 30 21 as as RB cord-001446-mpuovmeb 30 22 well well RB cord-001446-mpuovmeb 30 23 as as IN cord-001446-mpuovmeb 30 24 in in IN cord-001446-mpuovmeb 30 25 the the DT cord-001446-mpuovmeb 30 26 magnitude magnitude NN cord-001446-mpuovmeb 30 27 of of IN cord-001446-mpuovmeb 30 28 the the DT cord-001446-mpuovmeb 30 29 range range NN cord-001446-mpuovmeb 30 30 of of IN cord-001446-mpuovmeb 30 31 values value NNS cord-001446-mpuovmeb 30 32 in in IN cord-001446-mpuovmeb 30 33 this this DT cord-001446-mpuovmeb 30 34 population population NN cord-001446-mpuovmeb 30 35 . . . cord-001446-mpuovmeb 31 1 While while IN cord-001446-mpuovmeb 31 2 the the DT cord-001446-mpuovmeb 31 3 ELISA ELISA NNP cord-001446-mpuovmeb 31 4 configuration configuration NN cord-001446-mpuovmeb 31 5 used use VBN cord-001446-mpuovmeb 31 6 to to TO cord-001446-mpuovmeb 31 7 measure measure VB cord-001446-mpuovmeb 31 8 SP SP NNP cord-001446-mpuovmeb 31 9 - - HYPH cord-001446-mpuovmeb 31 10 D D NNP cord-001446-mpuovmeb 31 11 seemed seem VBD cord-001446-mpuovmeb 31 12 to to TO cord-001446-mpuovmeb 31 13 have have VB cord-001446-mpuovmeb 31 14 a a DT cord-001446-mpuovmeb 31 15 large large JJ cord-001446-mpuovmeb 31 16 impact impact NN cord-001446-mpuovmeb 31 17 on on IN cord-001446-mpuovmeb 31 18 the the DT cord-001446-mpuovmeb 31 19 values value NNS cord-001446-mpuovmeb 31 20 reported report VBN cord-001446-mpuovmeb 31 21 , , , cord-001446-mpuovmeb 31 22 there there EX cord-001446-mpuovmeb 31 23 are be VBP cord-001446-mpuovmeb 31 24 significant significant JJ cord-001446-mpuovmeb 31 25 variations variation NNS cord-001446-mpuovmeb 31 26 in in IN cord-001446-mpuovmeb 31 27 the the DT cord-001446-mpuovmeb 31 28 healthy healthy JJ cord-001446-mpuovmeb 31 29 control control NN cord-001446-mpuovmeb 31 30 SP SP NNP cord-001446-mpuovmeb 31 31 - - HYPH cord-001446-mpuovmeb 31 32 D d JJ cord-001446-mpuovmeb 31 33 levels level NNS cord-001446-mpuovmeb 31 34 and and CC cord-001446-mpuovmeb 31 35 range range VBP cord-001446-mpuovmeb 31 36 amongst amongst IN cord-001446-mpuovmeb 31 37 reports report NNS cord-001446-mpuovmeb 31 38 using use VBG cord-001446-mpuovmeb 31 39 the the DT cord-001446-mpuovmeb 31 40 same same JJ cord-001446-mpuovmeb 31 41 configuration configuration NN cord-001446-mpuovmeb 31 42 . . . cord-001446-mpuovmeb 32 1 The the DT cord-001446-mpuovmeb 32 2 purpose purpose NN cord-001446-mpuovmeb 32 3 of of IN cord-001446-mpuovmeb 32 4 this this DT cord-001446-mpuovmeb 32 5 study study NN cord-001446-mpuovmeb 32 6 is be VBZ cord-001446-mpuovmeb 32 7 to to TO cord-001446-mpuovmeb 32 8 determine determine VB cord-001446-mpuovmeb 32 9 factors factor NNS cord-001446-mpuovmeb 32 10 affecting affect VBG cord-001446-mpuovmeb 32 11 the the DT cord-001446-mpuovmeb 32 12 measurement measurement NN cord-001446-mpuovmeb 32 13 of of IN cord-001446-mpuovmeb 32 14 SP SP NNP cord-001446-mpuovmeb 32 15 - - HYPH cord-001446-mpuovmeb 32 16 D D NNP cord-001446-mpuovmeb 32 17 by by IN cord-001446-mpuovmeb 32 18 ELISA ELISA NNP cord-001446-mpuovmeb 32 19 that that WDT cord-001446-mpuovmeb 32 20 may may MD cord-001446-mpuovmeb 32 21 , , , cord-001446-mpuovmeb 32 22 therefore therefore RB cord-001446-mpuovmeb 32 23 , , , cord-001446-mpuovmeb 32 24 explain explain VB cord-001446-mpuovmeb 32 25 the the DT cord-001446-mpuovmeb 32 26 variations variation NNS cord-001446-mpuovmeb 32 27 of of IN cord-001446-mpuovmeb 32 28 serum serum NN cord-001446-mpuovmeb 32 29 and and CC cord-001446-mpuovmeb 32 30 plasma plasma NN cord-001446-mpuovmeb 32 31 SP sp NN cord-001446-mpuovmeb 32 32 - - HYPH cord-001446-mpuovmeb 32 33 D d JJ cord-001446-mpuovmeb 32 34 levels level NNS cord-001446-mpuovmeb 32 35 reported report VBN cord-001446-mpuovmeb 32 36 in in IN cord-001446-mpuovmeb 32 37 the the DT cord-001446-mpuovmeb 32 38 published publish VBN cord-001446-mpuovmeb 32 39 literature literature NN cord-001446-mpuovmeb 32 40 . . . cord-001446-mpuovmeb 33 1 All all DT cord-001446-mpuovmeb 33 2 human human JJ cord-001446-mpuovmeb 33 3 studies study NNS cord-001446-mpuovmeb 33 4 were be VBD cord-001446-mpuovmeb 33 5 approved approve VBN cord-001446-mpuovmeb 33 6 by by IN cord-001446-mpuovmeb 33 7 the the DT cord-001446-mpuovmeb 33 8 University University NNP cord-001446-mpuovmeb 33 9 of of IN cord-001446-mpuovmeb 33 10 Alabama Alabama NNP cord-001446-mpuovmeb 33 11 at at IN cord-001446-mpuovmeb 33 12 Birmingham Birmingham NNP cord-001446-mpuovmeb 33 13 Institutional Institutional NNP cord-001446-mpuovmeb 33 14 Review Review NNP cord-001446-mpuovmeb 33 15 Board Board NNP cord-001446-mpuovmeb 33 16 for for IN cord-001446-mpuovmeb 33 17 Human Human NNP cord-001446-mpuovmeb 33 18 Use Use NNP cord-001446-mpuovmeb 33 19 with with IN cord-001446-mpuovmeb 33 20 all all DT cord-001446-mpuovmeb 33 21 subjects subject NNS cord-001446-mpuovmeb 33 22 providing provide VBG cord-001446-mpuovmeb 33 23 written write VBN cord-001446-mpuovmeb 33 24 consent consent NN cord-001446-mpuovmeb 33 25 . . . cord-001446-mpuovmeb 34 1 Peripheral peripheral JJ cord-001446-mpuovmeb 34 2 blood blood NN cord-001446-mpuovmeb 34 3 was be VBD cord-001446-mpuovmeb 34 4 collected collect VBN cord-001446-mpuovmeb 34 5 from from IN cord-001446-mpuovmeb 34 6 healthy healthy JJ cord-001446-mpuovmeb 34 7 volunteers volunteer NNS cord-001446-mpuovmeb 34 8 by by IN cord-001446-mpuovmeb 34 9 venipuncture venipuncture NN cord-001446-mpuovmeb 34 10 into into IN cord-001446-mpuovmeb 34 11 serum serum NN cord-001446-mpuovmeb 34 12 , , , cord-001446-mpuovmeb 34 13 heparin heparin NN cord-001446-mpuovmeb 34 14 sulfate sulfate NN cord-001446-mpuovmeb 34 15 , , , cord-001446-mpuovmeb 34 16 K K NNP cord-001446-mpuovmeb 34 17 2 2 CD cord-001446-mpuovmeb 34 18 EDTA EDTA NNP cord-001446-mpuovmeb 34 19 , , , cord-001446-mpuovmeb 34 20 and and CC cord-001446-mpuovmeb 34 21 sodium sodium NN cord-001446-mpuovmeb 34 22 citrate citrate NNP cord-001446-mpuovmeb 34 23 vacutainers vacutainers NNP cord-001446-mpuovmeb 34 24 ( ( -LRB- cord-001446-mpuovmeb 34 25 BD BD NNP cord-001446-mpuovmeb 34 26 Biosciences Biosciences NNP cord-001446-mpuovmeb 34 27 ) ) -RRB- cord-001446-mpuovmeb 34 28 during during IN cord-001446-mpuovmeb 34 29 a a DT cord-001446-mpuovmeb 34 30 single single JJ cord-001446-mpuovmeb 34 31 draw draw NN cord-001446-mpuovmeb 34 32 . . . cord-001446-mpuovmeb 35 1 Samples sample NNS cord-001446-mpuovmeb 35 2 were be VBD cord-001446-mpuovmeb 35 3 kept keep VBN cord-001446-mpuovmeb 35 4 at at IN cord-001446-mpuovmeb 35 5 room room NN cord-001446-mpuovmeb 35 6 temperature temperature NN cord-001446-mpuovmeb 35 7 until until IN cord-001446-mpuovmeb 35 8 blood blood NN cord-001446-mpuovmeb 35 9 in in IN cord-001446-mpuovmeb 35 10 the the DT cord-001446-mpuovmeb 35 11 serum serum NN cord-001446-mpuovmeb 35 12 tube tube NN cord-001446-mpuovmeb 35 13 was be VBD cord-001446-mpuovmeb 35 14 coagulated coagulate VBN cord-001446-mpuovmeb 35 15 . . . cord-001446-mpuovmeb 36 1 Afterwards afterwards RB cord-001446-mpuovmeb 36 2 , , , cord-001446-mpuovmeb 36 3 samples sample NNS cord-001446-mpuovmeb 36 4 were be VBD cord-001446-mpuovmeb 36 5 centrifuged centrifuge VBN cord-001446-mpuovmeb 36 6 at at IN cord-001446-mpuovmeb 36 7 400xg 400xg NNP cord-001446-mpuovmeb 36 8 for for IN cord-001446-mpuovmeb 36 9 10 10 CD cord-001446-mpuovmeb 36 10 minutes minute NNS cord-001446-mpuovmeb 36 11 to to TO cord-001446-mpuovmeb 36 12 separate separate VB cord-001446-mpuovmeb 36 13 blood blood NN cord-001446-mpuovmeb 36 14 cells cell NNS cord-001446-mpuovmeb 36 15 from from IN cord-001446-mpuovmeb 36 16 serum serum NN cord-001446-mpuovmeb 36 17 or or CC cord-001446-mpuovmeb 36 18 plasma plasma NN cord-001446-mpuovmeb 36 19 . . . cord-001446-mpuovmeb 37 1 Samples sample NNS cord-001446-mpuovmeb 37 2 were be VBD cord-001446-mpuovmeb 37 3 either either CC cord-001446-mpuovmeb 37 4 directly directly RB cord-001446-mpuovmeb 37 5 aliquoted aliquote VBN cord-001446-mpuovmeb 37 6 and and CC cord-001446-mpuovmeb 37 7 stored store VBN cord-001446-mpuovmeb 37 8 at at IN cord-001446-mpuovmeb 37 9 280uC 280uc CD cord-001446-mpuovmeb 37 10 or or CC cord-001446-mpuovmeb 37 11 given give VBN cord-001446-mpuovmeb 37 12 an an DT cord-001446-mpuovmeb 37 13 additional additional JJ cord-001446-mpuovmeb 37 14 round round NN cord-001446-mpuovmeb 37 15 of of IN cord-001446-mpuovmeb 37 16 centrifugation centrifugation NN cord-001446-mpuovmeb 37 17 at at IN cord-001446-mpuovmeb 37 18 3000xg 3000xg NN cord-001446-mpuovmeb 37 19 for for IN cord-001446-mpuovmeb 37 20 10 10 CD cord-001446-mpuovmeb 37 21 minutes minute NNS cord-001446-mpuovmeb 37 22 to to TO cord-001446-mpuovmeb 37 23 separate separate VB cord-001446-mpuovmeb 37 24 platelets platelet NNS cord-001446-mpuovmeb 37 25 from from IN cord-001446-mpuovmeb 37 26 serum serum NN cord-001446-mpuovmeb 37 27 or or CC cord-001446-mpuovmeb 37 28 plasma plasma NN cord-001446-mpuovmeb 37 29 . . . cord-001446-mpuovmeb 38 1 All all DT cord-001446-mpuovmeb 38 2 serum serum NN cord-001446-mpuovmeb 38 3 and and CC cord-001446-mpuovmeb 38 4 plasma plasma NN cord-001446-mpuovmeb 38 5 sample sample NN cord-001446-mpuovmeb 38 6 values value NNS cord-001446-mpuovmeb 38 7 depicted depict VBN cord-001446-mpuovmeb 38 8 in in IN cord-001446-mpuovmeb 38 9 figures figure NNS cord-001446-mpuovmeb 38 10 were be VBD cord-001446-mpuovmeb 38 11 free free JJ cord-001446-mpuovmeb 38 12 of of IN cord-001446-mpuovmeb 38 13 platelets platelet NNS cord-001446-mpuovmeb 38 14 . . . cord-001446-mpuovmeb 39 1 All all DT cord-001446-mpuovmeb 39 2 experiments experiment NNS cord-001446-mpuovmeb 39 3 had have VBD cord-001446-mpuovmeb 39 4 6 6 CD cord-001446-mpuovmeb 39 5 samples sample NNS cord-001446-mpuovmeb 39 6 per per IN cord-001446-mpuovmeb 39 7 group group NN cord-001446-mpuovmeb 39 8 except except IN cord-001446-mpuovmeb 39 9 for for IN cord-001446-mpuovmeb 39 10 the the DT cord-001446-mpuovmeb 39 11 experiments experiment NNS cord-001446-mpuovmeb 39 12 depicted depict VBN cord-001446-mpuovmeb 39 13 in in IN cord-001446-mpuovmeb 39 14 _SP cord-001446-mpuovmeb 39 15 Mouse Mouse NNP cord-001446-mpuovmeb 39 16 antihuman antihuman NN cord-001446-mpuovmeb 39 17 SP sp NN cord-001446-mpuovmeb 39 18 - - HYPH cord-001446-mpuovmeb 39 19 D d JJ cord-001446-mpuovmeb 39 20 capture capture NN cord-001446-mpuovmeb 39 21 antibody antibody NN cord-001446-mpuovmeb 39 22 , , , cord-001446-mpuovmeb 39 23 biotinylated biotinylated JJ cord-001446-mpuovmeb 39 24 mouse mouse NN cord-001446-mpuovmeb 39 25 antihuman antihuman NN cord-001446-mpuovmeb 39 26 SP SP NNP cord-001446-mpuovmeb 39 27 - - HYPH cord-001446-mpuovmeb 39 28 D d JJ cord-001446-mpuovmeb 39 29 detection detection NN cord-001446-mpuovmeb 39 30 antibody antibody NN cord-001446-mpuovmeb 39 31 , , , cord-001446-mpuovmeb 39 32 streptavidin streptavidin NNP cord-001446-mpuovmeb 39 33 conjugated conjugate VBD cord-001446-mpuovmeb 39 34 to to IN cord-001446-mpuovmeb 39 35 horse horse NN cord-001446-mpuovmeb 39 36 radish radish NN cord-001446-mpuovmeb 39 37 peroxidase peroxidase NN cord-001446-mpuovmeb 39 38 , , , cord-001446-mpuovmeb 39 39 and and CC cord-001446-mpuovmeb 39 40 recombinant recombinant JJ cord-001446-mpuovmeb 39 41 human human JJ cord-001446-mpuovmeb 39 42 SP sp NN cord-001446-mpuovmeb 39 43 - - HYPH cord-001446-mpuovmeb 39 44 D D NNP cord-001446-mpuovmeb 39 45 standard standard NN cord-001446-mpuovmeb 39 46 were be VBD cord-001446-mpuovmeb 39 47 purchased purchase VBN cord-001446-mpuovmeb 39 48 as as IN cord-001446-mpuovmeb 39 49 a a DT cord-001446-mpuovmeb 39 50 kit kit NN cord-001446-mpuovmeb 39 51 from from IN cord-001446-mpuovmeb 39 52 R&D R&D NNP cord-001446-mpuovmeb 39 53 Systems Systems NNPS cord-001446-mpuovmeb 40 1 ( ( -LRB- cord-001446-mpuovmeb 40 2 Catalog catalog NN cord-001446-mpuovmeb 40 3 # # NN cord-001446-mpuovmeb 40 4 DY1920 dy1920 NN cord-001446-mpuovmeb 40 5 ) ) -RRB- cord-001446-mpuovmeb 40 6 and and CC cord-001446-mpuovmeb 40 7 used use VBD cord-001446-mpuovmeb 40 8 according accord VBG cord-001446-mpuovmeb 40 9 to to IN cord-001446-mpuovmeb 40 10 the the DT cord-001446-mpuovmeb 40 11 manufacturer manufacturer NN cord-001446-mpuovmeb 40 12 's 's POS cord-001446-mpuovmeb 40 13 protocol protocol NN cord-001446-mpuovmeb 40 14 . . . cord-001446-mpuovmeb 41 1 For for IN cord-001446-mpuovmeb 41 2 experiments experiment NNS cord-001446-mpuovmeb 41 3 testing test VBG cord-001446-mpuovmeb 41 4 the the DT cord-001446-mpuovmeb 41 5 effects effect NNS cord-001446-mpuovmeb 41 6 of of IN cord-001446-mpuovmeb 41 7 different different JJ cord-001446-mpuovmeb 41 8 matrices matrix NNS cord-001446-mpuovmeb 41 9 on on IN cord-001446-mpuovmeb 41 10 the the DT cord-001446-mpuovmeb 41 11 detection detection NN cord-001446-mpuovmeb 41 12 of of IN cord-001446-mpuovmeb 41 13 recombinant recombinant JJ cord-001446-mpuovmeb 41 14 human human JJ cord-001446-mpuovmeb 41 15 SP SP NNP cord-001446-mpuovmeb 41 16 - - HYPH cord-001446-mpuovmeb 41 17 D D NNP cord-001446-mpuovmeb 41 18 , , , cord-001446-mpuovmeb 41 19 a a DT cord-001446-mpuovmeb 41 20 concentrated concentrated JJ cord-001446-mpuovmeb 41 21 stock stock NN cord-001446-mpuovmeb 41 22 was be VBD cord-001446-mpuovmeb 41 23 made make VBN cord-001446-mpuovmeb 41 24 in in IN cord-001446-mpuovmeb 41 25 PBS PBS NNP cord-001446-mpuovmeb 41 26 with with IN cord-001446-mpuovmeb 41 27 1 1 CD cord-001446-mpuovmeb 41 28 % % NN cord-001446-mpuovmeb 41 29 BSA BSA NNP cord-001446-mpuovmeb 41 30 from from IN cord-001446-mpuovmeb 41 31 separately separately RB cord-001446-mpuovmeb 41 32 purchased purchase VBN cord-001446-mpuovmeb 41 33 recombinant recombinant JJ cord-001446-mpuovmeb 41 34 human human JJ cord-001446-mpuovmeb 41 35 SP SP NNP cord-001446-mpuovmeb 41 36 - - HYPH cord-001446-mpuovmeb 41 37 D D NNP cord-001446-mpuovmeb 41 38 expressed express VBD cord-001446-mpuovmeb 41 39 in in IN cord-001446-mpuovmeb 41 40 NSO NSO NNP cord-001446-mpuovmeb 41 41 cells cell NNS cord-001446-mpuovmeb 41 42 ( ( -LRB- cord-001446-mpuovmeb 41 43 R&D R&D NNP cord-001446-mpuovmeb 41 44 Systems Systems NNPS cord-001446-mpuovmeb 41 45 , , , cord-001446-mpuovmeb 41 46 Catalog catalog NN cord-001446-mpuovmeb 41 47 # # NN cord-001446-mpuovmeb 41 48 1920-SP-050 1920-sp-050 CD cord-001446-mpuovmeb 41 49 ) ) -RRB- cord-001446-mpuovmeb 41 50 . . . cord-001446-mpuovmeb 42 1 For for IN cord-001446-mpuovmeb 42 2 studies study NNS cord-001446-mpuovmeb 42 3 comparing compare VBG cord-001446-mpuovmeb 42 4 detection detection NN cord-001446-mpuovmeb 42 5 antibodies antibody NNS cord-001446-mpuovmeb 42 6 , , , cord-001446-mpuovmeb 42 7 polyclonal polyclonal JJ cord-001446-mpuovmeb 42 8 goat goat NN cord-001446-mpuovmeb 42 9 antihuman antihuman NN cord-001446-mpuovmeb 42 10 SP SP NNP cord-001446-mpuovmeb 42 11 - - HYPH cord-001446-mpuovmeb 42 12 D d JJ cord-001446-mpuovmeb 42 13 antibody antibody NN cord-001446-mpuovmeb 42 14 ( ( -LRB- cord-001446-mpuovmeb 42 15 R&D r&d NN cord-001446-mpuovmeb 42 16 systems system NNS cord-001446-mpuovmeb 42 17 , , , cord-001446-mpuovmeb 42 18 Catalog catalog NN cord-001446-mpuovmeb 42 19 # # NN cord-001446-mpuovmeb 42 20 AF1920 af1920 NN cord-001446-mpuovmeb 42 21 ) ) -RRB- cord-001446-mpuovmeb 42 22 was be VBD cord-001446-mpuovmeb 42 23 used use VBN cord-001446-mpuovmeb 42 24 instead instead RB cord-001446-mpuovmeb 42 25 with with IN cord-001446-mpuovmeb 42 26 a a DT cord-001446-mpuovmeb 42 27 monoclonal monoclonal JJ cord-001446-mpuovmeb 42 28 mouse mouse NN cord-001446-mpuovmeb 42 29 antigoat antigoat NNP cord-001446-mpuovmeb 42 30 conjugated conjugate VBD cord-001446-mpuovmeb 42 31 to to IN cord-001446-mpuovmeb 42 32 horse horse NN cord-001446-mpuovmeb 42 33 radish radish NN cord-001446-mpuovmeb 42 34 peroxidase peroxidase NN cord-001446-mpuovmeb 42 35 ( ( -LRB- cord-001446-mpuovmeb 42 36 Sigma Sigma NNP cord-001446-mpuovmeb 42 37 ) ) -RRB- cord-001446-mpuovmeb 42 38 used use VBD cord-001446-mpuovmeb 42 39 as as IN cord-001446-mpuovmeb 42 40 a a DT cord-001446-mpuovmeb 42 41 secondary secondary NN cord-001446-mpuovmeb 42 42 . . . cord-001446-mpuovmeb 43 1 All all DT cord-001446-mpuovmeb 43 2 sample sample NN cord-001446-mpuovmeb 43 3 values value NNS cord-001446-mpuovmeb 43 4 were be VBD cord-001446-mpuovmeb 43 5 extrapolated extrapolate VBN cord-001446-mpuovmeb 43 6 from from IN cord-001446-mpuovmeb 43 7 a a DT cord-001446-mpuovmeb 43 8 second second JJ cord-001446-mpuovmeb 43 9 order order NN cord-001446-mpuovmeb 43 10 polynomial polynomial NN cord-001446-mpuovmeb 43 11 curve curve NN cord-001446-mpuovmeb 43 12 fit fit NN cord-001446-mpuovmeb 43 13 of of IN cord-001446-mpuovmeb 43 14 9 9 CD cord-001446-mpuovmeb 43 15 concentrations concentration NNS cord-001446-mpuovmeb 43 16 of of IN cord-001446-mpuovmeb 43 17 the the DT cord-001446-mpuovmeb 43 18 standard standard NN cord-001446-mpuovmeb 43 19 ( ( -LRB- cord-001446-mpuovmeb 43 20 two two CD cord-001446-mpuovmeb 43 21 - - HYPH cord-001446-mpuovmeb 43 22 fold fold NN cord-001446-mpuovmeb 43 23 dilutions dilution NNS cord-001446-mpuovmeb 43 24 with with IN cord-001446-mpuovmeb 43 25 a a DT cord-001446-mpuovmeb 43 26 high high JJ cord-001446-mpuovmeb 43 27 concentration concentration NN cord-001446-mpuovmeb 43 28 of of IN cord-001446-mpuovmeb 43 29 40 40 CD cord-001446-mpuovmeb 43 30 ng ng NN cord-001446-mpuovmeb 43 31 / / SYM cord-001446-mpuovmeb 43 32 mL ml NN cord-001446-mpuovmeb 43 33 ) ) -RRB- cord-001446-mpuovmeb 43 34 diluted dilute VBN cord-001446-mpuovmeb 43 35 in in IN cord-001446-mpuovmeb 43 36 1 1 CD cord-001446-mpuovmeb 43 37 % % NN cord-001446-mpuovmeb 43 38 BSA BSA NNP cord-001446-mpuovmeb 43 39 PBS PBS NNP cord-001446-mpuovmeb 43 40 . . . cord-001446-mpuovmeb 44 1 Statistical statistical JJ cord-001446-mpuovmeb 44 2 analyses analysis NNS cord-001446-mpuovmeb 44 3 were be VBD cord-001446-mpuovmeb 44 4 performed perform VBN cord-001446-mpuovmeb 44 5 as as IN cord-001446-mpuovmeb 44 6 described describe VBN cord-001446-mpuovmeb 44 7 in in IN cord-001446-mpuovmeb 44 8 the the DT cord-001446-mpuovmeb 44 9 figure figure NN cord-001446-mpuovmeb 44 10 legends legend NNS cord-001446-mpuovmeb 44 11 using use VBG cord-001446-mpuovmeb 44 12 Prism Prism NNP cord-001446-mpuovmeb 44 13 5 5 CD cord-001446-mpuovmeb 44 14 ( ( -LRB- cord-001446-mpuovmeb 44 15 GraphPad GraphPad NNP cord-001446-mpuovmeb 44 16 Software Software NNP cord-001446-mpuovmeb 44 17 ) ) -RRB- cord-001446-mpuovmeb 44 18 , , , cord-001446-mpuovmeb 44 19 and and CC cord-001446-mpuovmeb 44 20 all all DT cord-001446-mpuovmeb 44 21 reported report VBD cord-001446-mpuovmeb 44 22 p p NN cord-001446-mpuovmeb 44 23 values value NNS cord-001446-mpuovmeb 44 24 are be VBP cord-001446-mpuovmeb 44 25 twotailed twotailed JJ cord-001446-mpuovmeb 44 26 . . . cord-001446-mpuovmeb 45 1 All all DT cord-001446-mpuovmeb 45 2 error error NN cord-001446-mpuovmeb 45 3 bars bar NNS cord-001446-mpuovmeb 45 4 represent represent VBP cord-001446-mpuovmeb 45 5 standard standard JJ cord-001446-mpuovmeb 45 6 deviation deviation NN cord-001446-mpuovmeb 45 7 . . . cord-001446-mpuovmeb 46 1 In in IN cord-001446-mpuovmeb 46 2 order order NN cord-001446-mpuovmeb 46 3 to to TO cord-001446-mpuovmeb 46 4 determine determine VB cord-001446-mpuovmeb 46 5 the the DT cord-001446-mpuovmeb 46 6 mean mean NN cord-001446-mpuovmeb 46 7 and and CC cord-001446-mpuovmeb 46 8 range range NN cord-001446-mpuovmeb 46 9 of of IN cord-001446-mpuovmeb 46 10 SP SP NNP cord-001446-mpuovmeb 46 11 - - HYPH cord-001446-mpuovmeb 46 12 D d JJ cord-001446-mpuovmeb 46 13 levels level NNS cord-001446-mpuovmeb 46 14 in in IN cord-001446-mpuovmeb 46 15 the the DT cord-001446-mpuovmeb 46 16 serum serum NN cord-001446-mpuovmeb 46 17 / / SYM cord-001446-mpuovmeb 46 18 plasma plasma NN cord-001446-mpuovmeb 46 19 of of IN cord-001446-mpuovmeb 46 20 normal normal JJ cord-001446-mpuovmeb 46 21 , , , cord-001446-mpuovmeb 46 22 healthy healthy JJ cord-001446-mpuovmeb 46 23 individuals individual NNS cord-001446-mpuovmeb 46 24 , , , cord-001446-mpuovmeb 46 25 we -PRON- PRP cord-001446-mpuovmeb 46 26 performed perform VBD cord-001446-mpuovmeb 46 27 a a DT cord-001446-mpuovmeb 46 28 non non JJ cord-001446-mpuovmeb 46 29 - - JJ cord-001446-mpuovmeb 46 30 exhaustive exhaustive JJ cord-001446-mpuovmeb 46 31 search search NN cord-001446-mpuovmeb 46 32 of of IN cord-001446-mpuovmeb 46 33 the the DT cord-001446-mpuovmeb 46 34 literature literature NN cord-001446-mpuovmeb 46 35 which which WDT cord-001446-mpuovmeb 46 36 revealed reveal VBD cord-001446-mpuovmeb 46 37 more more JJR cord-001446-mpuovmeb 46 38 than than IN cord-001446-mpuovmeb 46 39 60 60 CD cord-001446-mpuovmeb 46 40 publications publication NNS cord-001446-mpuovmeb 46 41 in in IN cord-001446-mpuovmeb 46 42 which which WDT cord-001446-mpuovmeb 46 43 these these DT cord-001446-mpuovmeb 46 44 values value NNS cord-001446-mpuovmeb 46 45 were be VBD cord-001446-mpuovmeb 46 46 described describe VBN cord-001446-mpuovmeb 46 47 . . . cord-001446-mpuovmeb 47 1 Interestingly interestingly RB cord-001446-mpuovmeb 47 2 , , , cord-001446-mpuovmeb 47 3 an an DT cord-001446-mpuovmeb 47 4 unexpected unexpected JJ cord-001446-mpuovmeb 47 5 amount amount NN cord-001446-mpuovmeb 47 6 of of IN cord-001446-mpuovmeb 47 7 variation variation NN cord-001446-mpuovmeb 47 8 on on IN cord-001446-mpuovmeb 47 9 these these DT cord-001446-mpuovmeb 47 10 reported report VBN cord-001446-mpuovmeb 47 11 values value NNS cord-001446-mpuovmeb 47 12 was be VBD cord-001446-mpuovmeb 47 13 observed observe VBN cord-001446-mpuovmeb 47 14 . . . cord-001446-mpuovmeb 48 1 When when WRB cord-001446-mpuovmeb 48 2 grouping group VBG cord-001446-mpuovmeb 48 3 according accord VBG cord-001446-mpuovmeb 48 4 to to IN cord-001446-mpuovmeb 48 5 the the DT cord-001446-mpuovmeb 48 6 ELISA ELISA NNP cord-001446-mpuovmeb 48 7 configuration configuration NN cord-001446-mpuovmeb 48 8 used use VBN cord-001446-mpuovmeb 48 9 , , , cord-001446-mpuovmeb 48 10 one one CD cord-001446-mpuovmeb 48 11 configuration configuration NN cord-001446-mpuovmeb 48 12 consistently consistently RB cord-001446-mpuovmeb 48 13 resulted result VBD cord-001446-mpuovmeb 48 14 in in IN cord-001446-mpuovmeb 48 15 significantly significantly RB cord-001446-mpuovmeb 48 16 higher high JJR cord-001446-mpuovmeb 48 17 values value NNS cord-001446-mpuovmeb 48 18 than than IN cord-001446-mpuovmeb 48 19 the the DT cord-001446-mpuovmeb 48 20 two two CD cord-001446-mpuovmeb 48 21 other other JJ cord-001446-mpuovmeb 48 22 configurations configuration NNS cord-001446-mpuovmeb 48 23 for for IN cord-001446-mpuovmeb 48 24 which which WDT cord-001446-mpuovmeb 48 25 multiple multiple JJ cord-001446-mpuovmeb 48 26 references reference NNS cord-001446-mpuovmeb 48 27 were be VBD cord-001446-mpuovmeb 48 28 obtained obtain VBN cord-001446-mpuovmeb 48 29 ( ( -LRB- cord-001446-mpuovmeb 48 30 Figure figure NN cord-001446-mpuovmeb 48 31 1a 1a CD cord-001446-mpuovmeb 48 32 ) ) -RRB- cord-001446-mpuovmeb 48 33 . . . cord-001446-mpuovmeb 49 1 For for IN cord-001446-mpuovmeb 49 2 each each DT cord-001446-mpuovmeb 49 3 configuration configuration NN cord-001446-mpuovmeb 49 4 , , , cord-001446-mpuovmeb 49 5 a a DT cord-001446-mpuovmeb 49 6 substantial substantial JJ cord-001446-mpuovmeb 49 7 range range NN cord-001446-mpuovmeb 49 8 of of IN cord-001446-mpuovmeb 49 9 means mean NNS cord-001446-mpuovmeb 49 10 / / SYM cord-001446-mpuovmeb 49 11 medians median NNS cord-001446-mpuovmeb 49 12 was be VBD cord-001446-mpuovmeb 49 13 observed observe VBN cord-001446-mpuovmeb 49 14 in in IN cord-001446-mpuovmeb 49 15 the the DT cord-001446-mpuovmeb 49 16 healthy healthy JJ cord-001446-mpuovmeb 49 17 control control NN cord-001446-mpuovmeb 49 18 population population NN cord-001446-mpuovmeb 49 19 . . . cord-001446-mpuovmeb 50 1 In in IN cord-001446-mpuovmeb 50 2 addition addition NN cord-001446-mpuovmeb 50 3 to to IN cord-001446-mpuovmeb 50 4 the the DT cord-001446-mpuovmeb 50 5 variations variation NNS cord-001446-mpuovmeb 50 6 seen see VBN cord-001446-mpuovmeb 50 7 in in IN cord-001446-mpuovmeb 50 8 the the DT cord-001446-mpuovmeb 50 9 averages average NNS cord-001446-mpuovmeb 50 10 , , , cord-001446-mpuovmeb 50 11 the the DT cord-001446-mpuovmeb 50 12 spectrum spectrum NN cord-001446-mpuovmeb 50 13 of of IN cord-001446-mpuovmeb 50 14 values value NNS cord-001446-mpuovmeb 50 15 in in IN cord-001446-mpuovmeb 50 16 all all DT cord-001446-mpuovmeb 50 17 populations population NNS cord-001446-mpuovmeb 50 18 ranged range VBD cord-001446-mpuovmeb 50 19 from from IN cord-001446-mpuovmeb 50 20 55.9 55.9 CD cord-001446-mpuovmeb 50 21 pg pg NN cord-001446-mpuovmeb 50 22 / / SYM cord-001446-mpuovmeb 50 23 mL mL NNP cord-001446-mpuovmeb 50 24 [ [ -LRB- cord-001446-mpuovmeb 50 25 22 22 CD cord-001446-mpuovmeb 50 26 ] ] -RRB- cord-001446-mpuovmeb 50 27 to to IN cord-001446-mpuovmeb 50 28 3.9653 3.9653 CD cord-001446-mpuovmeb 50 29 mg mg NNP cord-001446-mpuovmeb 50 30 / / SYM cord-001446-mpuovmeb 50 31 mL mL NNP cord-001446-mpuovmeb 50 32 [ [ -LRB- cord-001446-mpuovmeb 50 33 89 89 CD cord-001446-mpuovmeb 50 34 ] ] -RRB- cord-001446-mpuovmeb 50 35 , , , cord-001446-mpuovmeb 50 36 representing represent VBG cord-001446-mpuovmeb 50 37 a a DT cord-001446-mpuovmeb 50 38 more more JJR cord-001446-mpuovmeb 50 39 than than IN cord-001446-mpuovmeb 50 40 70,000 70,000 CD cord-001446-mpuovmeb 50 41 fold fold JJ cord-001446-mpuovmeb 50 42 difference difference NN cord-001446-mpuovmeb 50 43 . . . cord-001446-mpuovmeb 51 1 When when WRB cord-001446-mpuovmeb 51 2 examining examine VBG cord-001446-mpuovmeb 51 3 the the DT cord-001446-mpuovmeb 51 4 range range NN cord-001446-mpuovmeb 51 5 of of IN cord-001446-mpuovmeb 51 6 values value NNS cord-001446-mpuovmeb 51 7 seen see VBN cord-001446-mpuovmeb 51 8 in in IN cord-001446-mpuovmeb 51 9 healthy healthy JJ cord-001446-mpuovmeb 51 10 subjects subject NNS cord-001446-mpuovmeb 51 11 from from IN cord-001446-mpuovmeb 51 12 each each DT cord-001446-mpuovmeb 51 13 individual individual JJ cord-001446-mpuovmeb 51 14 study study NN cord-001446-mpuovmeb 51 15 and and CC cord-001446-mpuovmeb 51 16 grouping group VBG cord-001446-mpuovmeb 51 17 according accord VBG cord-001446-mpuovmeb 51 18 to to IN cord-001446-mpuovmeb 51 19 the the DT cord-001446-mpuovmeb 51 20 ELISA ELISA NNP cord-001446-mpuovmeb 51 21 configuration configuration NN cord-001446-mpuovmeb 51 22 used use VBN cord-001446-mpuovmeb 51 23 , , , cord-001446-mpuovmeb 51 24 a a DT cord-001446-mpuovmeb 51 25 large large JJ cord-001446-mpuovmeb 51 26 variation variation NN cord-001446-mpuovmeb 51 27 in in IN cord-001446-mpuovmeb 51 28 range range NN cord-001446-mpuovmeb 51 29 was be VBD cord-001446-mpuovmeb 51 30 observed observe VBN cord-001446-mpuovmeb 51 31 ( ( -LRB- cord-001446-mpuovmeb 51 32 Figure figure NN cord-001446-mpuovmeb 51 33 1b 1b CD cord-001446-mpuovmeb 51 34 ) ) -RRB- cord-001446-mpuovmeb 51 35 . . . cord-001446-mpuovmeb 52 1 Overall overall RB cord-001446-mpuovmeb 52 2 , , , cord-001446-mpuovmeb 52 3 the the DT cord-001446-mpuovmeb 52 4 study study NN cord-001446-mpuovmeb 52 5 with with IN cord-001446-mpuovmeb 52 6 the the DT cord-001446-mpuovmeb 52 7 smallest small JJS cord-001446-mpuovmeb 52 8 range range NN cord-001446-mpuovmeb 52 9 for for IN cord-001446-mpuovmeb 52 10 any any DT cord-001446-mpuovmeb 52 11 population population NN cord-001446-mpuovmeb 52 12 ( ( -LRB- cord-001446-mpuovmeb 52 13 as as IN cord-001446-mpuovmeb 52 14 a a DT cord-001446-mpuovmeb 52 15 percentage percentage NN cord-001446-mpuovmeb 52 16 of of IN cord-001446-mpuovmeb 52 17 the the DT cord-001446-mpuovmeb 52 18 average average NN cord-001446-mpuovmeb 52 19 ) ) -RRB- cord-001446-mpuovmeb 52 20 reported report VBD cord-001446-mpuovmeb 52 21 a a DT cord-001446-mpuovmeb 52 22 95 95 CD cord-001446-mpuovmeb 52 23 % % NN cord-001446-mpuovmeb 52 24 confidence confidence NN cord-001446-mpuovmeb 52 25 interval interval NN cord-001446-mpuovmeb 52 26 of of IN cord-001446-mpuovmeb 52 27 95.7 95.7 CD cord-001446-mpuovmeb 52 28 - - SYM cord-001446-mpuovmeb 52 29 109.0 109.0 CD cord-001446-mpuovmeb 52 30 [ [ -LRB- cord-001446-mpuovmeb 52 31 54 54 CD cord-001446-mpuovmeb 52 32 ] ] -RRB- cord-001446-mpuovmeb 52 33 , , , cord-001446-mpuovmeb 52 34 while while IN cord-001446-mpuovmeb 52 35 the the DT cord-001446-mpuovmeb 52 36 study study NN cord-001446-mpuovmeb 52 37 containing contain VBG cord-001446-mpuovmeb 52 38 the the DT cord-001446-mpuovmeb 52 39 population population NN cord-001446-mpuovmeb 52 40 with with IN cord-001446-mpuovmeb 52 41 the the DT cord-001446-mpuovmeb 52 42 largest large JJS cord-001446-mpuovmeb 52 43 range range NN cord-001446-mpuovmeb 52 44 reported report VBD cord-001446-mpuovmeb 52 45 a a DT cord-001446-mpuovmeb 52 46 standard standard JJ cord-001446-mpuovmeb 52 47 deviation deviation NN cord-001446-mpuovmeb 52 48 of of IN cord-001446-mpuovmeb 52 49 327 327 CD cord-001446-mpuovmeb 52 50 % % NN cord-001446-mpuovmeb 52 51 of of IN cord-001446-mpuovmeb 52 52 the the DT cord-001446-mpuovmeb 52 53 mean mean JJ cord-001446-mpuovmeb 52 54 value value NN cord-001446-mpuovmeb 52 55 [ [ -LRB- cord-001446-mpuovmeb 52 56 42 42 CD cord-001446-mpuovmeb 52 57 ] ] -RRB- cord-001446-mpuovmeb 52 58 . . . cord-001446-mpuovmeb 53 1 Based base VBN cord-001446-mpuovmeb 53 2 on on IN cord-001446-mpuovmeb 53 3 the the DT cord-001446-mpuovmeb 53 4 above above JJ cord-001446-mpuovmeb 53 5 observations observation NNS cord-001446-mpuovmeb 53 6 , , , cord-001446-mpuovmeb 53 7 we -PRON- PRP cord-001446-mpuovmeb 53 8 can can MD cord-001446-mpuovmeb 53 9 infer infer VB cord-001446-mpuovmeb 53 10 that that IN cord-001446-mpuovmeb 53 11 the the DT cord-001446-mpuovmeb 53 12 largest large JJS cord-001446-mpuovmeb 53 13 difference difference NN cord-001446-mpuovmeb 53 14 in in IN cord-001446-mpuovmeb 53 15 the the DT cord-001446-mpuovmeb 53 16 measured measure VBN cord-001446-mpuovmeb 53 17 levels level NNS cord-001446-mpuovmeb 53 18 of of IN cord-001446-mpuovmeb 53 19 SP SP NNP cord-001446-mpuovmeb 53 20 - - HYPH cord-001446-mpuovmeb 53 21 D D NNP cord-001446-mpuovmeb 53 22 is be VBZ cord-001446-mpuovmeb 53 23 due due JJ cord-001446-mpuovmeb 53 24 to to IN cord-001446-mpuovmeb 53 25 the the DT cord-001446-mpuovmeb 53 26 ELISA ELISA NNP cord-001446-mpuovmeb 53 27 configuration configuration NN cord-001446-mpuovmeb 53 28 employed employ VBN cord-001446-mpuovmeb 53 29 , , , cord-001446-mpuovmeb 53 30 but but CC cord-001446-mpuovmeb 53 31 that that IN cord-001446-mpuovmeb 53 32 there there EX cord-001446-mpuovmeb 53 33 are be VBP cord-001446-mpuovmeb 53 34 still still RB cord-001446-mpuovmeb 53 35 significant significant JJ cord-001446-mpuovmeb 53 36 differences difference NNS cord-001446-mpuovmeb 53 37 between between IN cord-001446-mpuovmeb 53 38 the the DT cord-001446-mpuovmeb 53 39 averages average NNS cord-001446-mpuovmeb 53 40 of of IN cord-001446-mpuovmeb 53 41 healthy healthy JJ cord-001446-mpuovmeb 53 42 individuals individual NNS cord-001446-mpuovmeb 53 43 from from IN cord-001446-mpuovmeb 53 44 studies study NNS cord-001446-mpuovmeb 53 45 using use VBG cord-001446-mpuovmeb 53 46 the the DT cord-001446-mpuovmeb 53 47 same same JJ cord-001446-mpuovmeb 53 48 configurations configuration NNS cord-001446-mpuovmeb 53 49 . . . cord-001446-mpuovmeb 54 1 In in IN cord-001446-mpuovmeb 54 2 order order NN cord-001446-mpuovmeb 54 3 to to TO cord-001446-mpuovmeb 54 4 compare compare VB cord-001446-mpuovmeb 54 5 the the DT cord-001446-mpuovmeb 54 6 results result NNS cord-001446-mpuovmeb 54 7 of of IN cord-001446-mpuovmeb 54 8 various various JJ cord-001446-mpuovmeb 54 9 studies study NNS cord-001446-mpuovmeb 54 10 in in IN cord-001446-mpuovmeb 54 11 another another DT cord-001446-mpuovmeb 54 12 manner manner NN cord-001446-mpuovmeb 54 13 , , , cord-001446-mpuovmeb 54 14 we -PRON- PRP cord-001446-mpuovmeb 54 15 examined examine VBD cord-001446-mpuovmeb 54 16 the the DT cord-001446-mpuovmeb 54 17 fold fold JJ cord-001446-mpuovmeb 54 18 change change NN cord-001446-mpuovmeb 54 19 from from IN cord-001446-mpuovmeb 54 20 healthy healthy JJ cord-001446-mpuovmeb 54 21 populations population NNS cord-001446-mpuovmeb 54 22 for for IN cord-001446-mpuovmeb 54 23 the the DT cord-001446-mpuovmeb 54 24 four four CD cord-001446-mpuovmeb 54 25 diseases disease NNS cord-001446-mpuovmeb 54 26 / / SYM cord-001446-mpuovmeb 54 27 conditions condition NNS cord-001446-mpuovmeb 54 28 for for IN cord-001446-mpuovmeb 54 29 which which WDT cord-001446-mpuovmeb 54 30 a a DT cord-001446-mpuovmeb 54 31 substantial substantial JJ cord-001446-mpuovmeb 54 32 number number NN cord-001446-mpuovmeb 54 33 of of IN cord-001446-mpuovmeb 54 34 publications publication NNS cord-001446-mpuovmeb 54 35 were be VBD cord-001446-mpuovmeb 54 36 available available JJ cord-001446-mpuovmeb 54 37 ( ( -LRB- cord-001446-mpuovmeb 54 38 IPF IPF NNP cord-001446-mpuovmeb 54 39 , , , cord-001446-mpuovmeb 54 40 CF CF NNP cord-001446-mpuovmeb 54 41 , , , cord-001446-mpuovmeb 54 42 cigarette cigarette NN cord-001446-mpuovmeb 54 43 smoking smoking NN cord-001446-mpuovmeb 54 44 , , , cord-001446-mpuovmeb 54 45 and and CC cord-001446-mpuovmeb 54 46 systemic systemic JJ cord-001446-mpuovmeb 54 47 sclerosis sclerosis NN cord-001446-mpuovmeb 54 48 ) ) -RRB- cord-001446-mpuovmeb 54 49 . . . cord-001446-mpuovmeb 55 1 This this DT cord-001446-mpuovmeb 55 2 would would MD cord-001446-mpuovmeb 55 3 allow allow VB cord-001446-mpuovmeb 55 4 us -PRON- PRP cord-001446-mpuovmeb 55 5 to to TO cord-001446-mpuovmeb 55 6 control control VB cord-001446-mpuovmeb 55 7 for for IN cord-001446-mpuovmeb 55 8 ELISA ELISA NNP cord-001446-mpuovmeb 55 9 configurations configuration NNS cord-001446-mpuovmeb 55 10 employed employ VBN cord-001446-mpuovmeb 55 11 , , , cord-001446-mpuovmeb 55 12 technical technical JJ cord-001446-mpuovmeb 55 13 protocol protocol NN cord-001446-mpuovmeb 55 14 followed follow VBD cord-001446-mpuovmeb 55 15 for for IN cord-001446-mpuovmeb 55 16 the the DT cord-001446-mpuovmeb 55 17 ELISA ELISA NNP cord-001446-mpuovmeb 55 18 as as RB cord-001446-mpuovmeb 55 19 well well RB cord-001446-mpuovmeb 55 20 as as IN cord-001446-mpuovmeb 55 21 for for IN cord-001446-mpuovmeb 55 22 sample sample NN cord-001446-mpuovmeb 55 23 collection collection NN cord-001446-mpuovmeb 55 24 and and CC cord-001446-mpuovmeb 55 25 processing processing NN cord-001446-mpuovmeb 55 26 , , , cord-001446-mpuovmeb 55 27 and and CC cord-001446-mpuovmeb 55 28 any any DT cord-001446-mpuovmeb 55 29 differences difference NNS cord-001446-mpuovmeb 55 30 in in IN cord-001446-mpuovmeb 55 31 the the DT cord-001446-mpuovmeb 55 32 populations population NNS cord-001446-mpuovmeb 55 33 ( ( -LRB- cord-001446-mpuovmeb 55 34 as as IN cord-001446-mpuovmeb 55 35 controls control NNS cord-001446-mpuovmeb 55 36 have have VBP cord-001446-mpuovmeb 55 37 been be VBN cord-001446-mpuovmeb 55 38 appropriately appropriately RB cord-001446-mpuovmeb 55 39 matched match VBN cord-001446-mpuovmeb 55 40 ) ) -RRB- cord-001446-mpuovmeb 55 41 . . . cord-001446-mpuovmeb 56 1 The the DT cord-001446-mpuovmeb 56 2 expectation expectation NN cord-001446-mpuovmeb 56 3 was be VBD cord-001446-mpuovmeb 56 4 that that IN cord-001446-mpuovmeb 56 5 the the DT cord-001446-mpuovmeb 56 6 fold fold JJ cord-001446-mpuovmeb 56 7 change change NN cord-001446-mpuovmeb 56 8 from from IN cord-001446-mpuovmeb 56 9 healthy healthy JJ cord-001446-mpuovmeb 56 10 would would MD cord-001446-mpuovmeb 56 11 be be VB cord-001446-mpuovmeb 56 12 very very RB cord-001446-mpuovmeb 56 13 similar similar JJ cord-001446-mpuovmeb 56 14 for for IN cord-001446-mpuovmeb 56 15 each each DT cord-001446-mpuovmeb 56 16 disease/ disease/ HYPH cord-001446-mpuovmeb 56 17 condition condition NN cord-001446-mpuovmeb 56 18 . . . cord-001446-mpuovmeb 57 1 However however RB cord-001446-mpuovmeb 57 2 , , , cord-001446-mpuovmeb 57 3 large large JJ cord-001446-mpuovmeb 57 4 differences difference NNS cord-001446-mpuovmeb 57 5 in in IN cord-001446-mpuovmeb 57 6 the the DT cord-001446-mpuovmeb 57 7 extent extent NN cord-001446-mpuovmeb 57 8 of of IN cord-001446-mpuovmeb 57 9 this this DT cord-001446-mpuovmeb 57 10 change change NN cord-001446-mpuovmeb 57 11 were be VBD cord-001446-mpuovmeb 57 12 observed observe VBN cord-001446-mpuovmeb 57 13 ( ( -LRB- cord-001446-mpuovmeb 57 14 Figure figure NN cord-001446-mpuovmeb 57 15 1c 1c CD cord-001446-mpuovmeb 57 16 ) ) -RRB- cord-001446-mpuovmeb 57 17 . . . cord-001446-mpuovmeb 58 1 In in IN cord-001446-mpuovmeb 58 2 order order NN cord-001446-mpuovmeb 58 3 to to TO cord-001446-mpuovmeb 58 4 determine determine VB cord-001446-mpuovmeb 58 5 if if IN cord-001446-mpuovmeb 58 6 the the DT cord-001446-mpuovmeb 58 7 matrix matrix NN cord-001446-mpuovmeb 58 8 used use VBN cord-001446-mpuovmeb 58 9 to to TO cord-001446-mpuovmeb 58 10 generate generate VB cord-001446-mpuovmeb 58 11 the the DT cord-001446-mpuovmeb 58 12 serial serial JJ cord-001446-mpuovmeb 58 13 dilutions dilution NNS cord-001446-mpuovmeb 58 14 of of IN cord-001446-mpuovmeb 58 15 recombinant recombinant JJ cord-001446-mpuovmeb 58 16 human human JJ cord-001446-mpuovmeb 58 17 standard standard NN cord-001446-mpuovmeb 58 18 ( ( -LRB- cord-001446-mpuovmeb 58 19 rhSP rhSP NNP cord-001446-mpuovmeb 58 20 - - HYPH cord-001446-mpuovmeb 58 21 D D NNP cord-001446-mpuovmeb 58 22 ) ) -RRB- cord-001446-mpuovmeb 58 23 had have VBD cord-001446-mpuovmeb 58 24 any any DT cord-001446-mpuovmeb 58 25 effects effect NNS cord-001446-mpuovmeb 58 26 upon upon IN cord-001446-mpuovmeb 58 27 measurement measurement NN cord-001446-mpuovmeb 58 28 , , , cord-001446-mpuovmeb 58 29 we -PRON- PRP cord-001446-mpuovmeb 58 30 compared compare VBD cord-001446-mpuovmeb 58 31 values value NNS cord-001446-mpuovmeb 58 32 produced produce VBN cord-001446-mpuovmeb 58 33 by by IN cord-001446-mpuovmeb 58 34 dilutions dilution NNS cord-001446-mpuovmeb 58 35 in in IN cord-001446-mpuovmeb 58 36 PBS PBS NNP cord-001446-mpuovmeb 58 37 , , , cord-001446-mpuovmeb 58 38 solutions solution NNS cord-001446-mpuovmeb 58 39 of of IN cord-001446-mpuovmeb 58 40 BSA BSA NNP cord-001446-mpuovmeb 58 41 ( ( -LRB- cord-001446-mpuovmeb 58 42 in in IN cord-001446-mpuovmeb 58 43 PBS PBS NNP cord-001446-mpuovmeb 58 44 ) ) -RRB- cord-001446-mpuovmeb 58 45 , , , cord-001446-mpuovmeb 58 46 and and CC cord-001446-mpuovmeb 58 47 solutions solution NNS cord-001446-mpuovmeb 58 48 of of IN cord-001446-mpuovmeb 58 49 FBS FBS NNP cord-001446-mpuovmeb 58 50 ( ( -LRB- cord-001446-mpuovmeb 58 51 diluted dilute VBN cord-001446-mpuovmeb 58 52 in in IN cord-001446-mpuovmeb 58 53 PBS PBS NNP cord-001446-mpuovmeb 58 54 ) ) -RRB- cord-001446-mpuovmeb 59 1 ( ( -LRB- cord-001446-mpuovmeb 59 2 Figure figure NN cord-001446-mpuovmeb 59 3 2 2 CD cord-001446-mpuovmeb 59 4 ) ) -RRB- cord-001446-mpuovmeb 59 5 . . . cord-001446-mpuovmeb 60 1 At at IN cord-001446-mpuovmeb 60 2 higher high JJR cord-001446-mpuovmeb 60 3 concentrations concentration NNS cord-001446-mpuovmeb 60 4 of of IN cord-001446-mpuovmeb 60 5 protein protein NN cord-001446-mpuovmeb 60 6 ( ( -LRB- cord-001446-mpuovmeb 60 7 i.e. i.e. FW cord-001446-mpuovmeb 60 8 5 5 CD cord-001446-mpuovmeb 60 9 % % NN cord-001446-mpuovmeb 60 10 BSA BSA NNP cord-001446-mpuovmeb 60 11 , , , cord-001446-mpuovmeb 60 12 50 50 CD cord-001446-mpuovmeb 60 13 % % NN cord-001446-mpuovmeb 60 14 FBS FBS NNP cord-001446-mpuovmeb 60 15 , , , cord-001446-mpuovmeb 60 16 and and CC cord-001446-mpuovmeb 60 17 100 100 CD cord-001446-mpuovmeb 60 18 % % NN cord-001446-mpuovmeb 60 19 FBS FBS NNP cord-001446-mpuovmeb 60 20 ) ) -RRB- cord-001446-mpuovmeb 60 21 , , , cord-001446-mpuovmeb 60 22 a a DT cord-001446-mpuovmeb 60 23 decrease decrease NN cord-001446-mpuovmeb 60 24 in in IN cord-001446-mpuovmeb 60 25 the the DT cord-001446-mpuovmeb 60 26 amount amount NN cord-001446-mpuovmeb 60 27 of of IN cord-001446-mpuovmeb 60 28 rhSP rhSP NNP cord-001446-mpuovmeb 60 29 - - HYPH cord-001446-mpuovmeb 60 30 D D NNP cord-001446-mpuovmeb 60 31 detected detect VBD cord-001446-mpuovmeb 60 32 was be VBD cord-001446-mpuovmeb 60 33 observed observe VBN cord-001446-mpuovmeb 60 34 , , , cord-001446-mpuovmeb 60 35 with with IN cord-001446-mpuovmeb 60 36 the the DT cord-001446-mpuovmeb 60 37 amount amount NN cord-001446-mpuovmeb 60 38 measured measure VBN cord-001446-mpuovmeb 60 39 in in IN cord-001446-mpuovmeb 60 40 samples sample NNS cord-001446-mpuovmeb 60 41 containing contain VBG cord-001446-mpuovmeb 60 42 10 10 CD cord-001446-mpuovmeb 60 43 ng ng NNP cord-001446-mpuovmeb 60 44 / / SYM cord-001446-mpuovmeb 60 45 mL mL NNP cord-001446-mpuovmeb 60 46 rhSP rhSP NNP cord-001446-mpuovmeb 60 47 - - HYPH cord-001446-mpuovmeb 60 48 D d NN cord-001446-mpuovmeb 60 49 being be VBG cord-001446-mpuovmeb 60 50 the the DT cord-001446-mpuovmeb 60 51 most most RBS cord-001446-mpuovmeb 60 52 variable variable NN cord-001446-mpuovmeb 60 53 of of IN cord-001446-mpuovmeb 60 54 any any DT cord-001446-mpuovmeb 60 55 samples sample NNS cord-001446-mpuovmeb 60 56 measured measure VBN cord-001446-mpuovmeb 60 57 in in IN cord-001446-mpuovmeb 60 58 this this DT cord-001446-mpuovmeb 60 59 assay assay NN cord-001446-mpuovmeb 60 60 . . . cord-001446-mpuovmeb 61 1 Using use VBG cord-001446-mpuovmeb 61 2 the the DT cord-001446-mpuovmeb 61 3 manufacturer manufacturer NN cord-001446-mpuovmeb 61 4 's 's POS cord-001446-mpuovmeb 61 5 recommended recommend VBN cord-001446-mpuovmeb 61 6 matrix matrix NN cord-001446-mpuovmeb 61 7 ( ( -LRB- cord-001446-mpuovmeb 61 8 1 1 CD cord-001446-mpuovmeb 61 9 % % NN cord-001446-mpuovmeb 61 10 BSA BSA NNP cord-001446-mpuovmeb 61 11 ) ) -RRB- cord-001446-mpuovmeb 61 12 produced produce VBD cord-001446-mpuovmeb 61 13 results result NNS cord-001446-mpuovmeb 61 14 very very RB cord-001446-mpuovmeb 61 15 similar similar JJ cord-001446-mpuovmeb 61 16 to to IN cord-001446-mpuovmeb 61 17 a a DT cord-001446-mpuovmeb 61 18 10 10 CD cord-001446-mpuovmeb 61 19 % % NN cord-001446-mpuovmeb 61 20 FBS fbs NN cord-001446-mpuovmeb 61 21 matrix matrix NN cord-001446-mpuovmeb 61 22 , , , cord-001446-mpuovmeb 61 23 with with IN cord-001446-mpuovmeb 61 24 both both CC cord-001446-mpuovmeb 61 25 giving give VBG cord-001446-mpuovmeb 61 26 very very RB cord-001446-mpuovmeb 61 27 consistent consistent JJ cord-001446-mpuovmeb 61 28 measurements measurement NNS cord-001446-mpuovmeb 61 29 and and CC cord-001446-mpuovmeb 61 30 the the DT cord-001446-mpuovmeb 61 31 greatest great JJS cord-001446-mpuovmeb 61 32 values value NNS cord-001446-mpuovmeb 61 33 . . . cord-001446-mpuovmeb 62 1 The the DT cord-001446-mpuovmeb 62 2 values value NNS cord-001446-mpuovmeb 62 3 for for IN cord-001446-mpuovmeb 62 4 PBS PBS NNP cord-001446-mpuovmeb 62 5 matrix matrix NN cord-001446-mpuovmeb 62 6 gave give VBD cord-001446-mpuovmeb 62 7 similarly similarly RB cord-001446-mpuovmeb 62 8 consistent consistent JJ cord-001446-mpuovmeb 62 9 measurements measurement NNS cord-001446-mpuovmeb 62 10 , , , cord-001446-mpuovmeb 62 11 but but CC cord-001446-mpuovmeb 62 12 at at IN cord-001446-mpuovmeb 62 13 a a DT cord-001446-mpuovmeb 62 14 slightly slightly RB cord-001446-mpuovmeb 62 15 lower low JJR cord-001446-mpuovmeb 62 16 value value NN cord-001446-mpuovmeb 62 17 . . . cord-001446-mpuovmeb 63 1 This this DT cord-001446-mpuovmeb 63 2 effect effect NN cord-001446-mpuovmeb 63 3 may may MD cord-001446-mpuovmeb 63 4 be be VB cord-001446-mpuovmeb 63 5 due due JJ cord-001446-mpuovmeb 63 6 to to IN cord-001446-mpuovmeb 63 7 adsorption adsorption NN cord-001446-mpuovmeb 63 8 of of IN cord-001446-mpuovmeb 63 9 rhSP rhSP NNP cord-001446-mpuovmeb 63 10 - - HYPH cord-001446-mpuovmeb 63 11 D D NNP cord-001446-mpuovmeb 63 12 without without IN cord-001446-mpuovmeb 63 13 a a DT cord-001446-mpuovmeb 63 14 carrier carrier NN cord-001446-mpuovmeb 63 15 protein protein NN cord-001446-mpuovmeb 63 16 to to IN cord-001446-mpuovmeb 63 17 the the DT cord-001446-mpuovmeb 63 18 tubes tube NNS cord-001446-mpuovmeb 63 19 used use VBN cord-001446-mpuovmeb 63 20 for for IN cord-001446-mpuovmeb 63 21 serial serial JJ cord-001446-mpuovmeb 63 22 dilutions dilution NNS cord-001446-mpuovmeb 63 23 [ [ -LRB- cord-001446-mpuovmeb 63 24 90 90 CD cord-001446-mpuovmeb 63 25 ] ] -RRB- cord-001446-mpuovmeb 63 26 . . . cord-001446-mpuovmeb 64 1 Serum serum NN cord-001446-mpuovmeb 64 2 Matrix Matrix NNP cord-001446-mpuovmeb 64 3 ( ( -LRB- cord-001446-mpuovmeb 64 4 Millipore Millipore NNP cord-001446-mpuovmeb 64 5 ) ) -RRB- cord-001446-mpuovmeb 64 6 , , , cord-001446-mpuovmeb 64 7 which which WDT cord-001446-mpuovmeb 64 8 had have VBD cord-001446-mpuovmeb 64 9 background background NN cord-001446-mpuovmeb 64 10 levels level NNS cord-001446-mpuovmeb 64 11 of of IN cord-001446-mpuovmeb 64 12 SP SP NNP cord-001446-mpuovmeb 64 13 - - HYPH cord-001446-mpuovmeb 64 14 D D NNP cord-001446-mpuovmeb 64 15 , , , cord-001446-mpuovmeb 64 16 also also RB cord-001446-mpuovmeb 64 17 inhibited inhibit VBD cord-001446-mpuovmeb 64 18 detection detection NN cord-001446-mpuovmeb 64 19 of of IN cord-001446-mpuovmeb 64 20 recombinant recombinant JJ cord-001446-mpuovmeb 64 21 SP SP NNP cord-001446-mpuovmeb 64 22 - - HYPH cord-001446-mpuovmeb 64 23 D D NNP cord-001446-mpuovmeb 64 24 at at IN cord-001446-mpuovmeb 64 25 higher high JJR cord-001446-mpuovmeb 64 26 concentrations concentration NNS cord-001446-mpuovmeb 64 27 . . . cord-001446-mpuovmeb 65 1 All all DT cord-001446-mpuovmeb 65 2 further further JJ cord-001446-mpuovmeb 65 3 standard standard JJ cord-001446-mpuovmeb 65 4 curves curve NNS cord-001446-mpuovmeb 65 5 were be VBD cord-001446-mpuovmeb 65 6 established establish VBN cord-001446-mpuovmeb 65 7 by by IN cord-001446-mpuovmeb 65 8 serial serial JJ cord-001446-mpuovmeb 65 9 dilutions dilution NNS cord-001446-mpuovmeb 65 10 of of IN cord-001446-mpuovmeb 65 11 recombinant recombinant JJ cord-001446-mpuovmeb 65 12 SP SP NNP cord-001446-mpuovmeb 65 13 - - HYPH cord-001446-mpuovmeb 65 14 D D NNP cord-001446-mpuovmeb 65 15 in in IN cord-001446-mpuovmeb 65 16 1 1 CD cord-001446-mpuovmeb 65 17 % % NN cord-001446-mpuovmeb 65 18 BSA BSA NNP cord-001446-mpuovmeb 65 19 in in IN cord-001446-mpuovmeb 65 20 PBS PBS NNP cord-001446-mpuovmeb 65 21 . . . cord-001446-mpuovmeb 66 1 One one CD cord-001446-mpuovmeb 66 2 factor factor NN cord-001446-mpuovmeb 66 3 that that WDT cord-001446-mpuovmeb 66 4 was be VBD cord-001446-mpuovmeb 66 5 found find VBN cord-001446-mpuovmeb 66 6 to to TO cord-001446-mpuovmeb 66 7 differ differ VB cord-001446-mpuovmeb 66 8 between between IN cord-001446-mpuovmeb 66 9 studies study NNS cord-001446-mpuovmeb 66 10 and and CC cord-001446-mpuovmeb 66 11 could could MD cord-001446-mpuovmeb 66 12 , , , cord-001446-mpuovmeb 66 13 therefore therefore RB cord-001446-mpuovmeb 66 14 , , , cord-001446-mpuovmeb 66 15 be be VB cord-001446-mpuovmeb 66 16 a a DT cord-001446-mpuovmeb 66 17 source source NN cord-001446-mpuovmeb 66 18 of of IN cord-001446-mpuovmeb 66 19 variation variation NN cord-001446-mpuovmeb 66 20 of of IN cord-001446-mpuovmeb 66 21 reported report VBN cord-001446-mpuovmeb 66 22 healthy healthy JJ cord-001446-mpuovmeb 66 23 population population NN cord-001446-mpuovmeb 66 24 values value NNS cord-001446-mpuovmeb 66 25 , , , cord-001446-mpuovmeb 66 26 was be VBD cord-001446-mpuovmeb 66 27 the the DT cord-001446-mpuovmeb 66 28 type type NN cord-001446-mpuovmeb 66 29 of of IN cord-001446-mpuovmeb 66 30 anticoagulant anticoagulant NN cord-001446-mpuovmeb 66 31 ( ( -LRB- cord-001446-mpuovmeb 66 32 or or CC cord-001446-mpuovmeb 66 33 lack lack NN cord-001446-mpuovmeb 66 34 thereof thereof RB cord-001446-mpuovmeb 66 35 ) ) -RRB- cord-001446-mpuovmeb 66 36 in in IN cord-001446-mpuovmeb 66 37 the the DT cord-001446-mpuovmeb 66 38 collection collection NN cord-001446-mpuovmeb 66 39 container container NN cord-001446-mpuovmeb 66 40 . . . cord-001446-mpuovmeb 67 1 When when WRB cord-001446-mpuovmeb 67 2 blood blood NN cord-001446-mpuovmeb 67 3 was be VBD cord-001446-mpuovmeb 67 4 simultaneously simultaneously RB cord-001446-mpuovmeb 67 5 collected collect VBN cord-001446-mpuovmeb 67 6 in in IN cord-001446-mpuovmeb 67 7 various various JJ cord-001446-mpuovmeb 67 8 vacutainers vacutainer NNS cord-001446-mpuovmeb 67 9 , , , cord-001446-mpuovmeb 67 10 serum serum NN cord-001446-mpuovmeb 67 11 and and CC cord-001446-mpuovmeb 67 12 heparin heparin NN cord-001446-mpuovmeb 67 13 plasma plasma NN cord-001446-mpuovmeb 67 14 gave give VBD cord-001446-mpuovmeb 67 15 similar similar JJ cord-001446-mpuovmeb 67 16 measurements measurement NNS cord-001446-mpuovmeb 67 17 of of IN cord-001446-mpuovmeb 67 18 SP SP NNP cord-001446-mpuovmeb 67 19 - - HYPH cord-001446-mpuovmeb 67 20 D D NNP cord-001446-mpuovmeb 67 21 , , , cord-001446-mpuovmeb 67 22 while while IN cord-001446-mpuovmeb 67 23 citrate citrate NN cord-001446-mpuovmeb 67 24 plasma plasma NN cord-001446-mpuovmeb 67 25 gave give VBD cord-001446-mpuovmeb 67 26 values value NNS cord-001446-mpuovmeb 67 27 significantly significantly RB cord-001446-mpuovmeb 67 28 lower low JJR cord-001446-mpuovmeb 67 29 than than IN cord-001446-mpuovmeb 67 30 serum serum NN cord-001446-mpuovmeb 67 31 values value NNS cord-001446-mpuovmeb 67 32 ( ( -LRB- cord-001446-mpuovmeb 67 33 Figure figure NN cord-001446-mpuovmeb 67 34 3 3 CD cord-001446-mpuovmeb 67 35 ) ) -RRB- cord-001446-mpuovmeb 67 36 . . . cord-001446-mpuovmeb 68 1 EDTA EDTA NNP cord-001446-mpuovmeb 68 2 plasma plasma NN cord-001446-mpuovmeb 68 3 gave give VBD cord-001446-mpuovmeb 68 4 the the DT cord-001446-mpuovmeb 68 5 most most RBS cord-001446-mpuovmeb 68 6 inconsistent inconsistent JJ cord-001446-mpuovmeb 68 7 results result NNS cord-001446-mpuovmeb 68 8 , , , cord-001446-mpuovmeb 68 9 and and CC cord-001446-mpuovmeb 68 10 values value NNS cord-001446-mpuovmeb 68 11 were be VBD cord-001446-mpuovmeb 68 12 also also RB cord-001446-mpuovmeb 68 13 significantly significantly RB cord-001446-mpuovmeb 68 14 lower low JJR cord-001446-mpuovmeb 68 15 than than IN cord-001446-mpuovmeb 68 16 serum serum NN cord-001446-mpuovmeb 68 17 values value NNS cord-001446-mpuovmeb 68 18 . . . cord-001446-mpuovmeb 69 1 In in IN cord-001446-mpuovmeb 69 2 order order NN cord-001446-mpuovmeb 69 3 to to TO cord-001446-mpuovmeb 69 4 determine determine VB cord-001446-mpuovmeb 69 5 if if IN cord-001446-mpuovmeb 69 6 calcium calcium NN cord-001446-mpuovmeb 69 7 concentration concentration NN cord-001446-mpuovmeb 69 8 in in IN cord-001446-mpuovmeb 69 9 the the DT cord-001446-mpuovmeb 69 10 sample sample NN cord-001446-mpuovmeb 69 11 had have VBD cord-001446-mpuovmeb 69 12 a a DT cord-001446-mpuovmeb 69 13 significant significant JJ cord-001446-mpuovmeb 69 14 effect effect NN cord-001446-mpuovmeb 69 15 upon upon IN cord-001446-mpuovmeb 69 16 the the DT cord-001446-mpuovmeb 69 17 measurement measurement NN cord-001446-mpuovmeb 69 18 of of IN cord-001446-mpuovmeb 69 19 SP SP NNP cord-001446-mpuovmeb 69 20 - - HYPH cord-001446-mpuovmeb 69 21 D D NNP cord-001446-mpuovmeb 69 22 , , , cord-001446-mpuovmeb 69 23 rhSP rhSP NNP cord-001446-mpuovmeb 69 24 - - HYPH cord-001446-mpuovmeb 69 25 D D NNP cord-001446-mpuovmeb 69 26 was be VBD cord-001446-mpuovmeb 69 27 assayed assay VBN cord-001446-mpuovmeb 69 28 in in IN cord-001446-mpuovmeb 69 29 serially serially RB cord-001446-mpuovmeb 69 30 diluted dilute VBN cord-001446-mpuovmeb 69 31 CaCl CaCl NNP cord-001446-mpuovmeb 69 32 2 2 CD cord-001446-mpuovmeb 69 33 or or CC cord-001446-mpuovmeb 69 34 EDTA EDTA NNP cord-001446-mpuovmeb 69 35 . . . cord-001446-mpuovmeb 70 1 The the DT cord-001446-mpuovmeb 70 2 detection detection NN cord-001446-mpuovmeb 70 3 of of IN cord-001446-mpuovmeb 70 4 rhSP rhSP NNP cord-001446-mpuovmeb 70 5 - - HYPH cord-001446-mpuovmeb 70 6 D D NNP cord-001446-mpuovmeb 70 7 was be VBD cord-001446-mpuovmeb 70 8 only only RB cord-001446-mpuovmeb 70 9 slightly slightly RB cord-001446-mpuovmeb 70 10 effected effect VBN cord-001446-mpuovmeb 70 11 by by IN cord-001446-mpuovmeb 70 12 the the DT cord-001446-mpuovmeb 70 13 changes change NNS cord-001446-mpuovmeb 70 14 in in IN cord-001446-mpuovmeb 70 15 calcium calcium NN cord-001446-mpuovmeb 70 16 concentration concentration NN cord-001446-mpuovmeb 70 17 in in IN cord-001446-mpuovmeb 70 18 the the DT cord-001446-mpuovmeb 70 19 sample sample NN cord-001446-mpuovmeb 70 20 ( ( -LRB- cord-001446-mpuovmeb 70 21 Figure figure NN cord-001446-mpuovmeb 70 22 4a 4a CD cord-001446-mpuovmeb 70 23 ) ) -RRB- cord-001446-mpuovmeb 70 24 . . . cord-001446-mpuovmeb 71 1 Additionally additionally RB cord-001446-mpuovmeb 71 2 , , , cord-001446-mpuovmeb 71 3 we -PRON- PRP cord-001446-mpuovmeb 71 4 examined examine VBD cord-001446-mpuovmeb 71 5 the the DT cord-001446-mpuovmeb 71 6 effects effect NNS cord-001446-mpuovmeb 71 7 of of IN cord-001446-mpuovmeb 71 8 calcium calcium NN cord-001446-mpuovmeb 71 9 concentration concentration NN cord-001446-mpuovmeb 71 10 in in IN cord-001446-mpuovmeb 71 11 the the DT cord-001446-mpuovmeb 71 12 human human JJ cord-001446-mpuovmeb 71 13 samples sample NNS cord-001446-mpuovmeb 71 14 by by IN cord-001446-mpuovmeb 71 15 adding add VBG cord-001446-mpuovmeb 71 16 calcium calcium NN cord-001446-mpuovmeb 71 17 to to IN cord-001446-mpuovmeb 71 18 EDTA edta NN cord-001446-mpuovmeb 71 19 plasma plasma NN cord-001446-mpuovmeb 71 20 samples sample NNS cord-001446-mpuovmeb 71 21 and and CC cord-001446-mpuovmeb 71 22 by by IN cord-001446-mpuovmeb 71 23 adding add VBG cord-001446-mpuovmeb 71 24 EDTA EDTA NNP cord-001446-mpuovmeb 71 25 to to IN cord-001446-mpuovmeb 71 26 serum serum NN cord-001446-mpuovmeb 71 27 samples sample NNS cord-001446-mpuovmeb 71 28 . . . cord-001446-mpuovmeb 72 1 While while IN cord-001446-mpuovmeb 72 2 reconstituting reconstitute VBG cord-001446-mpuovmeb 72 3 the the DT cord-001446-mpuovmeb 72 4 free free JJ cord-001446-mpuovmeb 72 5 calcium calcium NN cord-001446-mpuovmeb 72 6 in in IN cord-001446-mpuovmeb 72 7 the the DT cord-001446-mpuovmeb 72 8 EDTA EDTA NNP cord-001446-mpuovmeb 72 9 samples sample NNS cord-001446-mpuovmeb 72 10 had have VBD cord-001446-mpuovmeb 72 11 little little JJ cord-001446-mpuovmeb 72 12 effect effect NN cord-001446-mpuovmeb 72 13 , , , cord-001446-mpuovmeb 72 14 the the DT cord-001446-mpuovmeb 72 15 addition addition NN cord-001446-mpuovmeb 72 16 of of IN cord-001446-mpuovmeb 72 17 EDTA EDTA NNP cord-001446-mpuovmeb 72 18 to to IN cord-001446-mpuovmeb 72 19 the the DT cord-001446-mpuovmeb 72 20 serum serum NN cord-001446-mpuovmeb 72 21 samples sample NNS cord-001446-mpuovmeb 72 22 had have VBD cord-001446-mpuovmeb 72 23 a a DT cord-001446-mpuovmeb 72 24 dramatic dramatic JJ cord-001446-mpuovmeb 72 25 effect effect NN cord-001446-mpuovmeb 72 26 that that WDT cord-001446-mpuovmeb 72 27 was be VBD cord-001446-mpuovmeb 72 28 inconsistent inconsistent JJ cord-001446-mpuovmeb 72 29 amongst amongst IN cord-001446-mpuovmeb 72 30 the the DT cord-001446-mpuovmeb 72 31 patient patient NN cord-001446-mpuovmeb 72 32 samples sample NNS cord-001446-mpuovmeb 72 33 . . . cord-001446-mpuovmeb 73 1 While while IN cord-001446-mpuovmeb 73 2 many many JJ cord-001446-mpuovmeb 73 3 ELISAs elisa NNS cord-001446-mpuovmeb 73 4 employ employ VBP cord-001446-mpuovmeb 73 5 the the DT cord-001446-mpuovmeb 73 6 use use NN cord-001446-mpuovmeb 73 7 of of IN cord-001446-mpuovmeb 73 8 PBS PBS NNP cord-001446-mpuovmeb 73 9 lacking lack VBG cord-001446-mpuovmeb 73 10 divalent divalent JJ cord-001446-mpuovmeb 73 11 cations cation NNS cord-001446-mpuovmeb 73 12 as as IN cord-001446-mpuovmeb 73 13 a a DT cord-001446-mpuovmeb 73 14 buffer buffer NN cord-001446-mpuovmeb 73 15 during during IN cord-001446-mpuovmeb 73 16 the the DT cord-001446-mpuovmeb 73 17 detection detection NN cord-001446-mpuovmeb 73 18 of of IN cord-001446-mpuovmeb 73 19 antibody antibody NN cord-001446-mpuovmeb 73 20 - - HYPH cord-001446-mpuovmeb 73 21 captured capture VBN cord-001446-mpuovmeb 73 22 antigens antigen NNS cord-001446-mpuovmeb 73 23 , , , cord-001446-mpuovmeb 73 24 the the DT cord-001446-mpuovmeb 73 25 ELISA ELISA NNP cord-001446-mpuovmeb 73 26 configuration configuration NN cord-001446-mpuovmeb 73 27 employed employ VBN cord-001446-mpuovmeb 73 28 by by IN cord-001446-mpuovmeb 73 29 Holmskov Holmskov NNP cord-001446-mpuovmeb 73 30 et et NNP cord-001446-mpuovmeb 73 31 al al NNP cord-001446-mpuovmeb 73 32 . . NNP cord-001446-mpuovmeb 73 33 uses use VBZ cord-001446-mpuovmeb 73 34 a a DT cord-001446-mpuovmeb 73 35 Tris Tris NNP cord-001446-mpuovmeb 73 36 - - HYPH cord-001446-mpuovmeb 73 37 buffered buffer VBN cord-001446-mpuovmeb 73 38 saline saline NN cord-001446-mpuovmeb 73 39 solution solution NN cord-001446-mpuovmeb 73 40 containing contain VBG cord-001446-mpuovmeb 73 41 5 5 CD cord-001446-mpuovmeb 73 42 mM mm CD cord-001446-mpuovmeb 73 43 calcium calcium NN cord-001446-mpuovmeb 73 44 chloride chloride NN cord-001446-mpuovmeb 73 45 , , , cord-001446-mpuovmeb 73 46 as as IN cord-001446-mpuovmeb 73 47 the the DT cord-001446-mpuovmeb 73 48 monoclonal monoclonal JJ cord-001446-mpuovmeb 73 49 detection detection NN cord-001446-mpuovmeb 73 50 antibody antibody NN cord-001446-mpuovmeb 73 51 binds bind VBZ cord-001446-mpuovmeb 73 52 to to IN cord-001446-mpuovmeb 73 53 SP SP NNP cord-001446-mpuovmeb 73 54 - - HYPH cord-001446-mpuovmeb 73 55 D D NNP cord-001446-mpuovmeb 73 56 in in IN cord-001446-mpuovmeb 73 57 the the DT cord-001446-mpuovmeb 73 58 presence presence NN cord-001446-mpuovmeb 73 59 of of IN cord-001446-mpuovmeb 73 60 calcium calcium NN cord-001446-mpuovmeb 73 61 [ [ -LRB- cord-001446-mpuovmeb 73 62 58 58 CD cord-001446-mpuovmeb 73 63 ] ] -RRB- cord-001446-mpuovmeb 73 64 . . . cord-001446-mpuovmeb 74 1 In in IN cord-001446-mpuovmeb 74 2 addition addition NN cord-001446-mpuovmeb 74 3 , , , cord-001446-mpuovmeb 74 4 it -PRON- PRP cord-001446-mpuovmeb 74 5 was be VBD cord-001446-mpuovmeb 74 6 previously previously RB cord-001446-mpuovmeb 74 7 demonstrated demonstrate VBN cord-001446-mpuovmeb 74 8 that that IN cord-001446-mpuovmeb 74 9 SP SP NNP cord-001446-mpuovmeb 74 10 - - HYPH cord-001446-mpuovmeb 74 11 D D NNP cord-001446-mpuovmeb 74 12 has have VBZ cord-001446-mpuovmeb 74 13 the the DT cord-001446-mpuovmeb 74 14 ability ability NN cord-001446-mpuovmeb 74 15 to to TO cord-001446-mpuovmeb 74 16 bind bind VB cord-001446-mpuovmeb 74 17 to to IN cord-001446-mpuovmeb 74 18 various various JJ cord-001446-mpuovmeb 74 19 immunoglobulins immunoglobulin NNS cord-001446-mpuovmeb 74 20 in in IN cord-001446-mpuovmeb 74 21 a a DT cord-001446-mpuovmeb 74 22 calcium calcium NN cord-001446-mpuovmeb 74 23 - - HYPH cord-001446-mpuovmeb 74 24 dependent dependent JJ cord-001446-mpuovmeb 74 25 manner manner NN cord-001446-mpuovmeb 74 26 [ [ -LRB- cord-001446-mpuovmeb 74 27 91 91 CD cord-001446-mpuovmeb 74 28 ] ] -RRB- cord-001446-mpuovmeb 74 29 . . . cord-001446-mpuovmeb 75 1 In in IN cord-001446-mpuovmeb 75 2 order order NN cord-001446-mpuovmeb 75 3 to to TO cord-001446-mpuovmeb 75 4 determine determine VB cord-001446-mpuovmeb 75 5 the the DT cord-001446-mpuovmeb 75 6 effects effect NNS cord-001446-mpuovmeb 75 7 of of IN cord-001446-mpuovmeb 75 8 calcium calcium NN cord-001446-mpuovmeb 75 9 in in IN cord-001446-mpuovmeb 75 10 the the DT cord-001446-mpuovmeb 75 11 context context NN cord-001446-mpuovmeb 75 12 of of IN cord-001446-mpuovmeb 75 13 SP SP NNP cord-001446-mpuovmeb 75 14 - - HYPH cord-001446-mpuovmeb 75 15 D d JJ cord-001446-mpuovmeb 75 16 detection detection NN cord-001446-mpuovmeb 75 17 by by IN cord-001446-mpuovmeb 75 18 ELISA ELISA NNP cord-001446-mpuovmeb 75 19 , , , cord-001446-mpuovmeb 75 20 ELISAs elisa NNS cord-001446-mpuovmeb 75 21 were be VBD cord-001446-mpuovmeb 75 22 performed perform VBN cord-001446-mpuovmeb 75 23 with with IN cord-001446-mpuovmeb 75 24 antibodies antibody NNS cord-001446-mpuovmeb 75 25 diluted dilute VBN cord-001446-mpuovmeb 75 26 in in IN cord-001446-mpuovmeb 75 27 buffer buffer NN cord-001446-mpuovmeb 75 28 with with IN cord-001446-mpuovmeb 75 29 or or CC cord-001446-mpuovmeb 75 30 without without IN cord-001446-mpuovmeb 75 31 calcium calcium NN cord-001446-mpuovmeb 75 32 . . . cord-001446-mpuovmeb 76 1 We -PRON- PRP cord-001446-mpuovmeb 76 2 examined examine VBD cord-001446-mpuovmeb 76 3 these these DT cord-001446-mpuovmeb 76 4 effects effect NNS cord-001446-mpuovmeb 76 5 on on IN cord-001446-mpuovmeb 76 6 both both DT cord-001446-mpuovmeb 76 7 recombinant recombinant JJ cord-001446-mpuovmeb 76 8 SP SP NNP cord-001446-mpuovmeb 76 9 - - HYPH cord-001446-mpuovmeb 76 10 D D NNP cord-001446-mpuovmeb 76 11 and and CC cord-001446-mpuovmeb 76 12 SP SP NNP cord-001446-mpuovmeb 76 13 - - HYPH cord-001446-mpuovmeb 76 14 D D NNP cord-001446-mpuovmeb 76 15 in in IN cord-001446-mpuovmeb 76 16 plasma plasma NN cord-001446-mpuovmeb 76 17 with with IN cord-001446-mpuovmeb 76 18 either either CC cord-001446-mpuovmeb 76 19 the the DT cord-001446-mpuovmeb 76 20 ELISA ELISA NNP cord-001446-mpuovmeb 76 21 kit kit NN cord-001446-mpuovmeb 76 22 's 's POS cord-001446-mpuovmeb 76 23 detection detection NN cord-001446-mpuovmeb 76 24 antibody antibody NN cord-001446-mpuovmeb 76 25 or or CC cord-001446-mpuovmeb 76 26 a a DT cord-001446-mpuovmeb 76 27 polyclonal polyclonal JJ cord-001446-mpuovmeb 76 28 goat goat NN cord-001446-mpuovmeb 76 29 anti anti JJ cord-001446-mpuovmeb 76 30 - - JJ cord-001446-mpuovmeb 76 31 SP sp JJ cord-001446-mpuovmeb 76 32 - - HYPH cord-001446-mpuovmeb 76 33 D d JJ cord-001446-mpuovmeb 76 34 antibody antibody NN cord-001446-mpuovmeb 76 35 produced produce VBN cord-001446-mpuovmeb 76 36 by by IN cord-001446-mpuovmeb 76 37 the the DT cord-001446-mpuovmeb 76 38 same same JJ cord-001446-mpuovmeb 76 39 manufacturer manufacturer NN cord-001446-mpuovmeb 76 40 . . . cord-001446-mpuovmeb 77 1 In in IN cord-001446-mpuovmeb 77 2 all all DT cord-001446-mpuovmeb 77 3 cases case NNS cord-001446-mpuovmeb 77 4 but but CC cord-001446-mpuovmeb 77 5 one one CD cord-001446-mpuovmeb 77 6 , , , cord-001446-mpuovmeb 77 7 the the DT cord-001446-mpuovmeb 77 8 addition addition NN cord-001446-mpuovmeb 77 9 of of IN cord-001446-mpuovmeb 77 10 5 5 CD cord-001446-mpuovmeb 77 11 mM mm NN cord-001446-mpuovmeb 77 12 calcium calcium NN cord-001446-mpuovmeb 77 13 to to IN cord-001446-mpuovmeb 77 14 the the DT cord-001446-mpuovmeb 77 15 dilution dilution NN cord-001446-mpuovmeb 77 16 and and CC cord-001446-mpuovmeb 77 17 wash wash NN cord-001446-mpuovmeb 77 18 buffer buffer NN cord-001446-mpuovmeb 77 19 resulted result VBD cord-001446-mpuovmeb 77 20 in in IN cord-001446-mpuovmeb 77 21 a a DT cord-001446-mpuovmeb 77 22 small small JJ cord-001446-mpuovmeb 77 23 ( ( -LRB- cord-001446-mpuovmeb 77 24 , , , cord-001446-mpuovmeb 77 25 17 17 CD cord-001446-mpuovmeb 77 26 % % NN cord-001446-mpuovmeb 77 27 ) ) -RRB- cord-001446-mpuovmeb 77 28 but but CC cord-001446-mpuovmeb 77 29 significant significant JJ cord-001446-mpuovmeb 77 30 increase increase NN cord-001446-mpuovmeb 77 31 in in IN cord-001446-mpuovmeb 77 32 SP SP NNP cord-001446-mpuovmeb 77 33 - - HYPH cord-001446-mpuovmeb 77 34 D d JJ cord-001446-mpuovmeb 77 35 concentration concentration NN cord-001446-mpuovmeb 77 36 relative relative NN cord-001446-mpuovmeb 77 37 to to IN cord-001446-mpuovmeb 77 38 detection detection NN cord-001446-mpuovmeb 77 39 in in IN cord-001446-mpuovmeb 77 40 the the DT cord-001446-mpuovmeb 77 41 absence absence NN cord-001446-mpuovmeb 77 42 of of IN cord-001446-mpuovmeb 77 43 calcium calcium NN cord-001446-mpuovmeb 77 44 ( ( -LRB- cord-001446-mpuovmeb 77 45 Figure figure NN cord-001446-mpuovmeb 77 46 4b 4b CD cord-001446-mpuovmeb 77 47 ) ) -RRB- cord-001446-mpuovmeb 77 48 . . . cord-001446-mpuovmeb 78 1 It -PRON- PRP cord-001446-mpuovmeb 78 2 is be VBZ cord-001446-mpuovmeb 78 3 important important JJ cord-001446-mpuovmeb 78 4 to to TO cord-001446-mpuovmeb 78 5 note note VB cord-001446-mpuovmeb 78 6 that that IN cord-001446-mpuovmeb 78 7 with with IN cord-001446-mpuovmeb 78 8 the the DT cord-001446-mpuovmeb 78 9 kit kit NN cord-001446-mpuovmeb 78 10 reagents reagent NNS cord-001446-mpuovmeb 78 11 , , , cord-001446-mpuovmeb 78 12 since since IN cord-001446-mpuovmeb 78 13 the the DT cord-001446-mpuovmeb 78 14 relative relative JJ cord-001446-mpuovmeb 78 15 increase increase NN cord-001446-mpuovmeb 78 16 in in IN cord-001446-mpuovmeb 78 17 detection detection NN cord-001446-mpuovmeb 78 18 of of IN cord-001446-mpuovmeb 78 19 recombinant recombinant JJ cord-001446-mpuovmeb 78 20 SP SP NNP cord-001446-mpuovmeb 78 21 - - HYPH cord-001446-mpuovmeb 78 22 D D NNP cord-001446-mpuovmeb 78 23 and and CC cord-001446-mpuovmeb 78 24 SP SP NNP cord-001446-mpuovmeb 78 25 - - HYPH cord-001446-mpuovmeb 78 26 D D NNP cord-001446-mpuovmeb 78 27 in in IN cord-001446-mpuovmeb 78 28 plasma plasma NN cord-001446-mpuovmeb 78 29 in in IN cord-001446-mpuovmeb 78 30 the the DT cord-001446-mpuovmeb 78 31 presence presence NN cord-001446-mpuovmeb 78 32 of of IN cord-001446-mpuovmeb 78 33 calcium calcium NN cord-001446-mpuovmeb 78 34 is be VBZ cord-001446-mpuovmeb 78 35 very very RB cord-001446-mpuovmeb 78 36 similar similar JJ cord-001446-mpuovmeb 78 37 , , , cord-001446-mpuovmeb 78 38 the the DT cord-001446-mpuovmeb 78 39 extrapolated extrapolate VBN cord-001446-mpuovmeb 78 40 SP SP NNP cord-001446-mpuovmeb 78 41 - - HYPH cord-001446-mpuovmeb 78 42 D d JJ cord-001446-mpuovmeb 78 43 concentration concentration NN cord-001446-mpuovmeb 78 44 in in IN cord-001446-mpuovmeb 78 45 plasma plasma NN cord-001446-mpuovmeb 78 46 when when WRB cord-001446-mpuovmeb 78 47 using use VBG cord-001446-mpuovmeb 78 48 a a DT cord-001446-mpuovmeb 78 49 standard standard JJ cord-001446-mpuovmeb 78 50 curve curve NN cord-001446-mpuovmeb 78 51 of of IN cord-001446-mpuovmeb 78 52 recombinant recombinant JJ cord-001446-mpuovmeb 78 53 SP SP NNP cord-001446-mpuovmeb 78 54 - - HYPH cord-001446-mpuovmeb 78 55 D D NNP cord-001446-mpuovmeb 78 56 should should MD cord-001446-mpuovmeb 78 57 not not RB cord-001446-mpuovmeb 78 58 significantly significantly RB cord-001446-mpuovmeb 78 59 change change VB cord-001446-mpuovmeb 78 60 . . . cord-001446-mpuovmeb 79 1 Interestingly interestingly RB cord-001446-mpuovmeb 79 2 , , , cord-001446-mpuovmeb 79 3 while while IN cord-001446-mpuovmeb 79 4 the the DT cord-001446-mpuovmeb 79 5 inclusion inclusion NN cord-001446-mpuovmeb 79 6 of of IN cord-001446-mpuovmeb 79 7 calcium calcium NN cord-001446-mpuovmeb 79 8 increased increase VBD cord-001446-mpuovmeb 79 9 the the DT cord-001446-mpuovmeb 79 10 recognition recognition NN cord-001446-mpuovmeb 79 11 of of IN cord-001446-mpuovmeb 79 12 native native JJ cord-001446-mpuovmeb 79 13 SP SP NNP cord-001446-mpuovmeb 79 14 - - HYPH cord-001446-mpuovmeb 79 15 D D NNP cord-001446-mpuovmeb 79 16 by by IN cord-001446-mpuovmeb 79 17 the the DT cord-001446-mpuovmeb 79 18 polyclonal polyclonal JJ cord-001446-mpuovmeb 79 19 antibody antibody NN cord-001446-mpuovmeb 79 20 , , , cord-001446-mpuovmeb 79 21 it -PRON- PRP cord-001446-mpuovmeb 79 22 had have VBD cord-001446-mpuovmeb 79 23 no no DT cord-001446-mpuovmeb 79 24 effect effect NN cord-001446-mpuovmeb 79 25 on on IN cord-001446-mpuovmeb 79 26 the the DT cord-001446-mpuovmeb 79 27 detection detection NN cord-001446-mpuovmeb 79 28 of of IN cord-001446-mpuovmeb 79 29 recombinant recombinant JJ cord-001446-mpuovmeb 79 30 SP SP NNP cord-001446-mpuovmeb 79 31 - - HYPH cord-001446-mpuovmeb 79 32 D D NNP cord-001446-mpuovmeb 79 33 by by IN cord-001446-mpuovmeb 79 34 this this DT cord-001446-mpuovmeb 79 35 antibody antibody NN cord-001446-mpuovmeb 79 36 . . . cord-001446-mpuovmeb 80 1 Although although IN cord-001446-mpuovmeb 80 2 it -PRON- PRP cord-001446-mpuovmeb 80 3 is be VBZ cord-001446-mpuovmeb 80 4 beyond beyond IN cord-001446-mpuovmeb 80 5 the the DT cord-001446-mpuovmeb 80 6 scope scope NN cord-001446-mpuovmeb 80 7 of of IN cord-001446-mpuovmeb 80 8 this this DT cord-001446-mpuovmeb 80 9 study study NN cord-001446-mpuovmeb 80 10 , , , cord-001446-mpuovmeb 80 11 future future JJ cord-001446-mpuovmeb 80 12 work work NN cord-001446-mpuovmeb 80 13 will will MD cord-001446-mpuovmeb 80 14 explore explore VB cord-001446-mpuovmeb 80 15 whether whether IN cord-001446-mpuovmeb 80 16 this this DT cord-001446-mpuovmeb 80 17 effect effect NN cord-001446-mpuovmeb 80 18 is be VBZ cord-001446-mpuovmeb 80 19 due due JJ cord-001446-mpuovmeb 80 20 to to IN cord-001446-mpuovmeb 80 21 an an DT cord-001446-mpuovmeb 80 22 increase increase NN cord-001446-mpuovmeb 80 23 in in IN cord-001446-mpuovmeb 80 24 antibody antibody NN cord-001446-mpuovmeb 80 25 recognition recognition NN cord-001446-mpuovmeb 80 26 of of IN cord-001446-mpuovmeb 80 27 antigen antigen NN cord-001446-mpuovmeb 80 28 , , , cord-001446-mpuovmeb 80 29 increase increase NN cord-001446-mpuovmeb 80 30 in in IN cord-001446-mpuovmeb 80 31 non non JJ cord-001446-mpuovmeb 80 32 - - JJ cord-001446-mpuovmeb 80 33 specific specific JJ cord-001446-mpuovmeb 80 34 binding binding NN cord-001446-mpuovmeb 80 35 of of IN cord-001446-mpuovmeb 80 36 antibodies antibody NNS cord-001446-mpuovmeb 80 37 by by IN cord-001446-mpuovmeb 80 38 captured capture VBN cord-001446-mpuovmeb 80 39 SP SP NNP cord-001446-mpuovmeb 80 40 - - HYPH cord-001446-mpuovmeb 80 41 D D NNP cord-001446-mpuovmeb 80 42 , , , cord-001446-mpuovmeb 80 43 or or CC cord-001446-mpuovmeb 80 44 an an DT cord-001446-mpuovmeb 80 45 increase increase NN cord-001446-mpuovmeb 80 46 through through IN cord-001446-mpuovmeb 80 47 another another DT cord-001446-mpuovmeb 80 48 mechanism mechanism NN cord-001446-mpuovmeb 80 49 . . . cord-001446-mpuovmeb 81 1 Given give VBN cord-001446-mpuovmeb 81 2 that that IN cord-001446-mpuovmeb 81 3 some some DT cord-001446-mpuovmeb 81 4 of of IN cord-001446-mpuovmeb 81 5 the the DT cord-001446-mpuovmeb 81 6 variation variation NN cord-001446-mpuovmeb 81 7 seen see VBN cord-001446-mpuovmeb 81 8 in in IN cord-001446-mpuovmeb 81 9 the the DT cord-001446-mpuovmeb 81 10 published publish VBN cord-001446-mpuovmeb 81 11 literature literature NN cord-001446-mpuovmeb 81 12 might may MD cord-001446-mpuovmeb 81 13 be be VB cord-001446-mpuovmeb 81 14 explained explain VBN cord-001446-mpuovmeb 81 15 by by IN cord-001446-mpuovmeb 81 16 the the DT cord-001446-mpuovmeb 81 17 use use NN cord-001446-mpuovmeb 81 18 of of IN cord-001446-mpuovmeb 81 19 different different JJ cord-001446-mpuovmeb 81 20 antibodies antibody NNS cord-001446-mpuovmeb 81 21 , , , cord-001446-mpuovmeb 81 22 we -PRON- PRP cord-001446-mpuovmeb 81 23 detected detect VBD cord-001446-mpuovmeb 81 24 SP SP NNP cord-001446-mpuovmeb 81 25 - - HYPH cord-001446-mpuovmeb 81 26 D D NNP cord-001446-mpuovmeb 81 27 in in IN cord-001446-mpuovmeb 81 28 serum serum NN cord-001446-mpuovmeb 81 29 and and CC cord-001446-mpuovmeb 81 30 plasma plasma NN cord-001446-mpuovmeb 81 31 samples sample NNS cord-001446-mpuovmeb 81 32 using use VBG cord-001446-mpuovmeb 81 33 either either CC cord-001446-mpuovmeb 81 34 the the DT cord-001446-mpuovmeb 81 35 ELISA ELISA NNP cord-001446-mpuovmeb 81 36 kit kit NN cord-001446-mpuovmeb 81 37 's 's POS cord-001446-mpuovmeb 81 38 detection detection NN cord-001446-mpuovmeb 81 39 antibody antibody NN cord-001446-mpuovmeb 81 40 or or CC cord-001446-mpuovmeb 81 41 the the DT cord-001446-mpuovmeb 81 42 polyclonal polyclonal JJ cord-001446-mpuovmeb 81 43 goat goat NN cord-001446-mpuovmeb 81 44 anti anti NNP cord-001446-mpuovmeb 81 45 - - JJ cord-001446-mpuovmeb 81 46 SP sp JJ cord-001446-mpuovmeb 81 47 - - HYPH cord-001446-mpuovmeb 81 48 D d JJ cord-001446-mpuovmeb 81 49 antibody antibody NN cord-001446-mpuovmeb 81 50 . . . cord-001446-mpuovmeb 82 1 While while IN cord-001446-mpuovmeb 82 2 there there EX cord-001446-mpuovmeb 82 3 is be VBZ cord-001446-mpuovmeb 82 4 no no DT cord-001446-mpuovmeb 82 5 significant significant JJ cord-001446-mpuovmeb 82 6 difference difference NN cord-001446-mpuovmeb 82 7 between between IN cord-001446-mpuovmeb 82 8 detection detection NN cord-001446-mpuovmeb 82 9 by by IN cord-001446-mpuovmeb 82 10 the the DT cord-001446-mpuovmeb 82 11 [ [ -LRB- cord-001446-mpuovmeb 82 12 12 12 CD cord-001446-mpuovmeb 82 13 , , , cord-001446-mpuovmeb 82 14 [ [ -LRB- cord-001446-mpuovmeb 82 15 16 16 CD cord-001446-mpuovmeb 82 16 ] ] -RRB- cord-001446-mpuovmeb 82 17 [ [ -LRB- cord-001446-mpuovmeb 82 18 17 17 CD cord-001446-mpuovmeb 82 19 ] ] -RRB- cord-001446-mpuovmeb 82 20 [ [ -LRB- cord-001446-mpuovmeb 82 21 18 18 CD cord-001446-mpuovmeb 82 22 ] ] -RRB- cord-001446-mpuovmeb 82 23 [ [ -LRB- cord-001446-mpuovmeb 82 24 19 19 CD cord-001446-mpuovmeb 82 25 ] ] -RRB- cord-001446-mpuovmeb 82 26 21 21 CD cord-001446-mpuovmeb 82 27 ] ] -RRB- cord-001446-mpuovmeb 82 28 , , , cord-001446-mpuovmeb 82 29 CF CF NNP cord-001446-mpuovmeb 82 30 [ [ -LRB- cord-001446-mpuovmeb 82 31 15 15 CD cord-001446-mpuovmeb 82 32 , , , cord-001446-mpuovmeb 82 33 38 38 CD cord-001446-mpuovmeb 82 34 , , , cord-001446-mpuovmeb 82 35 39 39 CD cord-001446-mpuovmeb 82 36 ] ] -RRB- cord-001446-mpuovmeb 82 37 , , , cord-001446-mpuovmeb 82 38 cigarette cigarette NN cord-001446-mpuovmeb 82 39 smoking smoking NN cord-001446-mpuovmeb 82 40 [ [ -LRB- cord-001446-mpuovmeb 82 41 28 28 CD cord-001446-mpuovmeb 82 42 , , , cord-001446-mpuovmeb 82 43 31 31 CD cord-001446-mpuovmeb 82 44 , , , cord-001446-mpuovmeb 82 45 [ [ -LRB- cord-001446-mpuovmeb 82 46 72 72 CD cord-001446-mpuovmeb 82 47 ] ] -RRB- cord-001446-mpuovmeb 82 48 [ [ -LRB- cord-001446-mpuovmeb 82 49 73 73 CD cord-001446-mpuovmeb 82 50 ] ] -RRB- cord-001446-mpuovmeb 82 51 [ [ -LRB- cord-001446-mpuovmeb 82 52 74 74 CD cord-001446-mpuovmeb 82 53 ] ] -RRB- cord-001446-mpuovmeb 82 54 [ [ -LRB- cord-001446-mpuovmeb 82 55 75 75 CD cord-001446-mpuovmeb 82 56 ] ] -RRB- cord-001446-mpuovmeb 82 57 , , , cord-001446-mpuovmeb 82 58 or or CC cord-001446-mpuovmeb 82 59 sclerosis sclerosis NN cord-001446-mpuovmeb 82 60 [ [ -LRB- cord-001446-mpuovmeb 82 61 42 42 CD cord-001446-mpuovmeb 82 62 ] ] -RRB- cord-001446-mpuovmeb 82 63 [ [ -LRB- cord-001446-mpuovmeb 82 64 43 43 CD cord-001446-mpuovmeb 82 65 ] ] -RRB- cord-001446-mpuovmeb 82 66 [ [ -LRB- cord-001446-mpuovmeb 82 67 44 44 CD cord-001446-mpuovmeb 82 68 ] ] -RRB- cord-001446-mpuovmeb 82 69 46 46 CD cord-001446-mpuovmeb 82 70 ] ] -RRB- cord-001446-mpuovmeb 82 71 was be VBD cord-001446-mpuovmeb 82 72 different different JJ cord-001446-mpuovmeb 82 73 between between IN cord-001446-mpuovmeb 82 74 publications publication NNS cord-001446-mpuovmeb 82 75 . . . cord-001446-mpuovmeb 83 1 An an DT cord-001446-mpuovmeb 83 2 asterisk asterisk NN cord-001446-mpuovmeb 83 3 ( ( -LRB- cord-001446-mpuovmeb 83 4 * * NFP cord-001446-mpuovmeb 83 5 ) ) -RRB- cord-001446-mpuovmeb 83 6 denotes denote VBZ cord-001446-mpuovmeb 83 7 p#0.001 p#0.001 PRP cord-001446-mpuovmeb 83 8 by by IN cord-001446-mpuovmeb 83 9 one one CD cord-001446-mpuovmeb 83 10 - - HYPH cord-001446-mpuovmeb 83 11 way way NN cord-001446-mpuovmeb 83 12 ANOVA anova NN cord-001446-mpuovmeb 83 13 with with IN cord-001446-mpuovmeb 83 14 Tukey Tukey NNP cord-001446-mpuovmeb 83 15 's 's POS cord-001446-mpuovmeb 83 16 multiple multiple JJ cord-001446-mpuovmeb 83 17 comparison comparison NN cord-001446-mpuovmeb 83 18 test test NN cord-001446-mpuovmeb 83 19 . . . cord-001446-mpuovmeb 84 1 doi:10.1371 doi:10.1371 NNP cord-001446-mpuovmeb 84 2 / / SYM cord-001446-mpuovmeb 84 3 journal.pone.0111466.g001 journal.pone.0111466.g001 NNP cord-001446-mpuovmeb 84 4 kit kit NN cord-001446-mpuovmeb 84 5 antibody antibody NN cord-001446-mpuovmeb 84 6 versus versus IN cord-001446-mpuovmeb 84 7 the the DT cord-001446-mpuovmeb 84 8 polyclonal polyclonal JJ cord-001446-mpuovmeb 84 9 goat goat NN cord-001446-mpuovmeb 84 10 antibody antibody NN cord-001446-mpuovmeb 84 11 with with IN cord-001446-mpuovmeb 84 12 regard regard NN cord-001446-mpuovmeb 84 13 to to IN cord-001446-mpuovmeb 84 14 the the DT cord-001446-mpuovmeb 84 15 type type NN cord-001446-mpuovmeb 84 16 of of IN cord-001446-mpuovmeb 84 17 collection collection NN cord-001446-mpuovmeb 84 18 tube tube NN cord-001446-mpuovmeb 84 19 used use VBN cord-001446-mpuovmeb 84 20 , , , cord-001446-mpuovmeb 84 21 overall overall RB cord-001446-mpuovmeb 84 22 , , , cord-001446-mpuovmeb 84 23 there there EX cord-001446-mpuovmeb 84 24 is be VBZ cord-001446-mpuovmeb 84 25 a a DT cord-001446-mpuovmeb 84 26 , , , cord-001446-mpuovmeb 84 27 50 50 CD cord-001446-mpuovmeb 84 28 % % NN cord-001446-mpuovmeb 84 29 reduction reduction NN cord-001446-mpuovmeb 84 30 in in IN cord-001446-mpuovmeb 84 31 the the DT cord-001446-mpuovmeb 84 32 extrapolated extrapolate VBN cord-001446-mpuovmeb 84 33 value value NN cord-001446-mpuovmeb 84 34 produced produce VBN cord-001446-mpuovmeb 84 35 by by IN cord-001446-mpuovmeb 84 36 detection detection NN cord-001446-mpuovmeb 84 37 with with IN cord-001446-mpuovmeb 84 38 the the DT cord-001446-mpuovmeb 84 39 polyclonal polyclonal JJ cord-001446-mpuovmeb 84 40 goat goat NN cord-001446-mpuovmeb 84 41 antibody antibody NN cord-001446-mpuovmeb 84 42 compared compare VBN cord-001446-mpuovmeb 84 43 to to IN cord-001446-mpuovmeb 84 44 the the DT cord-001446-mpuovmeb 84 45 kit kit NN cord-001446-mpuovmeb 84 46 antibody antibody NN cord-001446-mpuovmeb 84 47 ( ( -LRB- cord-001446-mpuovmeb 84 48 Figure figure NN cord-001446-mpuovmeb 84 49 5 5 CD cord-001446-mpuovmeb 84 50 ) ) -RRB- cord-001446-mpuovmeb 84 51 . . . cord-001446-mpuovmeb 85 1 In in IN cord-001446-mpuovmeb 85 2 both both DT cord-001446-mpuovmeb 85 3 cases case NNS cord-001446-mpuovmeb 85 4 , , , cord-001446-mpuovmeb 85 5 the the DT cord-001446-mpuovmeb 85 6 same same JJ cord-001446-mpuovmeb 85 7 capture capture NN cord-001446-mpuovmeb 85 8 antibody antibody NN cord-001446-mpuovmeb 85 9 was be VBD cord-001446-mpuovmeb 85 10 employed employ VBN cord-001446-mpuovmeb 85 11 , , , cord-001446-mpuovmeb 85 12 and and CC cord-001446-mpuovmeb 85 13 it -PRON- PRP cord-001446-mpuovmeb 85 14 is be VBZ cord-001446-mpuovmeb 85 15 therefore therefore RB cord-001446-mpuovmeb 85 16 possible possible JJ cord-001446-mpuovmeb 85 17 that that IN cord-001446-mpuovmeb 85 18 using use VBG cord-001446-mpuovmeb 85 19 a a DT cord-001446-mpuovmeb 85 20 different different JJ cord-001446-mpuovmeb 85 21 capture capture NN cord-001446-mpuovmeb 85 22 antibody antibody NN cord-001446-mpuovmeb 85 23 could could MD cord-001446-mpuovmeb 85 24 have have VB cord-001446-mpuovmeb 85 25 a a DT cord-001446-mpuovmeb 85 26 similar similar JJ cord-001446-mpuovmeb 85 27 effect effect NN cord-001446-mpuovmeb 85 28 on on IN cord-001446-mpuovmeb 85 29 varying vary VBG cord-001446-mpuovmeb 85 30 the the DT cord-001446-mpuovmeb 85 31 extrapolated extrapolate VBN cord-001446-mpuovmeb 85 32 SP SP NNP cord-001446-mpuovmeb 85 33 - - HYPH cord-001446-mpuovmeb 85 34 D d JJ cord-001446-mpuovmeb 85 35 concentration concentration NN cord-001446-mpuovmeb 85 36 in in IN cord-001446-mpuovmeb 85 37 the the DT cord-001446-mpuovmeb 85 38 sample sample NN cord-001446-mpuovmeb 85 39 . . . cord-001446-mpuovmeb 86 1 Another another DT cord-001446-mpuovmeb 86 2 factor factor NN cord-001446-mpuovmeb 86 3 that that WDT cord-001446-mpuovmeb 86 4 fluctuated fluctuate VBD cord-001446-mpuovmeb 86 5 from from IN cord-001446-mpuovmeb 86 6 study study NN cord-001446-mpuovmeb 86 7 to to TO cord-001446-mpuovmeb 86 8 study study VB cord-001446-mpuovmeb 86 9 was be VBD cord-001446-mpuovmeb 86 10 whether whether IN cord-001446-mpuovmeb 86 11 the the DT cord-001446-mpuovmeb 86 12 sample sample NN cord-001446-mpuovmeb 86 13 was be VBD cord-001446-mpuovmeb 86 14 assayed assay VBN cord-001446-mpuovmeb 86 15 neat neat JJ cord-001446-mpuovmeb 86 16 or or CC cord-001446-mpuovmeb 86 17 the the DT cord-001446-mpuovmeb 86 18 sample sample NN cord-001446-mpuovmeb 86 19 was be VBD cord-001446-mpuovmeb 86 20 prediluted predilute VBN cord-001446-mpuovmeb 86 21 ( ( -LRB- cord-001446-mpuovmeb 86 22 and and CC cord-001446-mpuovmeb 86 23 the the DT cord-001446-mpuovmeb 86 24 amount amount NN cord-001446-mpuovmeb 86 25 the the DT cord-001446-mpuovmeb 86 26 sample sample NN cord-001446-mpuovmeb 86 27 was be VBD cord-001446-mpuovmeb 86 28 diluted dilute VBN cord-001446-mpuovmeb 86 29 ) ) -RRB- cord-001446-mpuovmeb 86 30 . . . cord-001446-mpuovmeb 87 1 Given give VBN cord-001446-mpuovmeb 87 2 this this DT cord-001446-mpuovmeb 87 3 fact fact NN cord-001446-mpuovmeb 87 4 and and CC cord-001446-mpuovmeb 87 5 that that IN cord-001446-mpuovmeb 87 6 diluting dilute VBG cord-001446-mpuovmeb 87 7 recombinant recombinant JJ cord-001446-mpuovmeb 87 8 SP SP NNP cord-001446-mpuovmeb 87 9 - - HYPH cord-001446-mpuovmeb 87 10 D D NNP cord-001446-mpuovmeb 87 11 into into IN cord-001446-mpuovmeb 87 12 100 100 CD cord-001446-mpuovmeb 87 13 % % NN cord-001446-mpuovmeb 87 14 FBS FBS NNP cord-001446-mpuovmeb 87 15 had have VBD cord-001446-mpuovmeb 87 16 some some DT cord-001446-mpuovmeb 87 17 influence influence NN cord-001446-mpuovmeb 87 18 in in IN cord-001446-mpuovmeb 87 19 the the DT cord-001446-mpuovmeb 87 20 detection detection NN cord-001446-mpuovmeb 87 21 of of IN cord-001446-mpuovmeb 87 22 said say VBN cord-001446-mpuovmeb 87 23 SP SP NNP cord-001446-mpuovmeb 87 24 - - HYPH cord-001446-mpuovmeb 87 25 D D NNP cord-001446-mpuovmeb 87 26 , , , cord-001446-mpuovmeb 87 27 we -PRON- PRP cord-001446-mpuovmeb 87 28 compared compare VBD cord-001446-mpuovmeb 87 29 SP SP NNP cord-001446-mpuovmeb 87 30 - - HYPH cord-001446-mpuovmeb 87 31 D d JJ cord-001446-mpuovmeb 87 32 values value NNS cord-001446-mpuovmeb 87 33 detected detect VBN cord-001446-mpuovmeb 87 34 in in IN cord-001446-mpuovmeb 87 35 undiluted undiluted JJ cord-001446-mpuovmeb 87 36 and and CC cord-001446-mpuovmeb 87 37 diluted diluted JJ cord-001446-mpuovmeb 87 38 samples sample NNS cord-001446-mpuovmeb 87 39 . . . cord-001446-mpuovmeb 88 1 There there EX cord-001446-mpuovmeb 88 2 was be VBD cord-001446-mpuovmeb 88 3 a a DT cord-001446-mpuovmeb 88 4 very very RB cord-001446-mpuovmeb 88 5 minimal minimal JJ cord-001446-mpuovmeb 88 6 difference difference NN cord-001446-mpuovmeb 88 7 between between IN cord-001446-mpuovmeb 88 8 values value NNS cord-001446-mpuovmeb 88 9 produced produce VBN cord-001446-mpuovmeb 88 10 by by IN cord-001446-mpuovmeb 88 11 undiluted undiluted JJ cord-001446-mpuovmeb 88 12 and and CC cord-001446-mpuovmeb 88 13 10 10 CD cord-001446-mpuovmeb 88 14 fold fold JJ cord-001446-mpuovmeb 88 15 diluted diluted JJ cord-001446-mpuovmeb 88 16 serum serum NN cord-001446-mpuovmeb 88 17 , , , cord-001446-mpuovmeb 88 18 citrate citrate NN cord-001446-mpuovmeb 88 19 plasma plasma NN cord-001446-mpuovmeb 88 20 , , , cord-001446-mpuovmeb 88 21 and and CC cord-001446-mpuovmeb 88 22 heparin heparin NN cord-001446-mpuovmeb 88 23 plasma plasma NN cord-001446-mpuovmeb 88 24 ( ( -LRB- cord-001446-mpuovmeb 88 25 Figure Figure NNP cord-001446-mpuovmeb 88 26 6 6 CD cord-001446-mpuovmeb 88 27 ) ) -RRB- cord-001446-mpuovmeb 88 28 . . . cord-001446-mpuovmeb 89 1 Ten ten CD cord-001446-mpuovmeb 89 2 fold fold VB cord-001446-mpuovmeb 89 3 diluted dilute VBN cord-001446-mpuovmeb 89 4 EDTA edta NN cord-001446-mpuovmeb 89 5 plasma plasma NN cord-001446-mpuovmeb 89 6 , , , cord-001446-mpuovmeb 89 7 however however RB cord-001446-mpuovmeb 89 8 , , , cord-001446-mpuovmeb 89 9 produced produce VBD cord-001446-mpuovmeb 89 10 a a DT cord-001446-mpuovmeb 89 11 significantly significantly RB cord-001446-mpuovmeb 89 12 higher high JJR cord-001446-mpuovmeb 89 13 extrapolated extrapolate VBN cord-001446-mpuovmeb 89 14 SP SP NNP cord-001446-mpuovmeb 89 15 - - HYPH cord-001446-mpuovmeb 89 16 D d JJ cord-001446-mpuovmeb 89 17 value value NN cord-001446-mpuovmeb 89 18 when when WRB cord-001446-mpuovmeb 89 19 compared compare VBN cord-001446-mpuovmeb 89 20 to to IN cord-001446-mpuovmeb 89 21 the the DT cord-001446-mpuovmeb 89 22 same same JJ cord-001446-mpuovmeb 89 23 sample sample NN cord-001446-mpuovmeb 89 24 undiluted undiluted JJ cord-001446-mpuovmeb 89 25 . . . cord-001446-mpuovmeb 90 1 This this DT cord-001446-mpuovmeb 90 2 same same JJ cord-001446-mpuovmeb 90 3 effect effect NN cord-001446-mpuovmeb 90 4 was be VBD cord-001446-mpuovmeb 90 5 seen see VBN cord-001446-mpuovmeb 90 6 when when WRB cord-001446-mpuovmeb 90 7 the the DT cord-001446-mpuovmeb 90 8 polyclonal polyclonal JJ cord-001446-mpuovmeb 90 9 goat goat NN cord-001446-mpuovmeb 90 10 antibody antibody NN cord-001446-mpuovmeb 90 11 tested test VBN cord-001446-mpuovmeb 90 12 above above RB cord-001446-mpuovmeb 90 13 was be VBD cord-001446-mpuovmeb 90 14 used use VBN cord-001446-mpuovmeb 90 15 for for IN cord-001446-mpuovmeb 90 16 detection detection NN cord-001446-mpuovmeb 90 17 ( ( -LRB- cord-001446-mpuovmeb 90 18 data datum NNS cord-001446-mpuovmeb 90 19 not not RB cord-001446-mpuovmeb 90 20 shown show VBN cord-001446-mpuovmeb 90 21 ) ) -RRB- cord-001446-mpuovmeb 90 22 . . . cord-001446-mpuovmeb 91 1 While while IN cord-001446-mpuovmeb 91 2 the the DT cord-001446-mpuovmeb 91 3 most most RBS cord-001446-mpuovmeb 91 4 common common JJ cord-001446-mpuovmeb 91 5 processing processing NN cord-001446-mpuovmeb 91 6 technique technique NN cord-001446-mpuovmeb 91 7 involved involve VBN cord-001446-mpuovmeb 91 8 separating separate VBG cord-001446-mpuovmeb 91 9 the the DT cord-001446-mpuovmeb 91 10 blood blood NN cord-001446-mpuovmeb 91 11 cells cell NNS cord-001446-mpuovmeb 91 12 ( ( -LRB- cord-001446-mpuovmeb 91 13 but but CC cord-001446-mpuovmeb 91 14 not not RB cord-001446-mpuovmeb 91 15 platelets platelet NNS cord-001446-mpuovmeb 91 16 ) ) -RRB- cord-001446-mpuovmeb 91 17 from from IN cord-001446-mpuovmeb 91 18 serum serum NN cord-001446-mpuovmeb 91 19 and and CC cord-001446-mpuovmeb 91 20 plasma plasma NN cord-001446-mpuovmeb 91 21 and and CC cord-001446-mpuovmeb 91 22 storing store VBG cord-001446-mpuovmeb 91 23 this this DT cord-001446-mpuovmeb 91 24 sample sample NN cord-001446-mpuovmeb 91 25 at at IN cord-001446-mpuovmeb 91 26 280uC 280uc CD cord-001446-mpuovmeb 91 27 until until IN cord-001446-mpuovmeb 91 28 assayed assay VBN cord-001446-mpuovmeb 91 29 , , , cord-001446-mpuovmeb 91 30 some some DT cord-001446-mpuovmeb 91 31 variations variation NNS cord-001446-mpuovmeb 91 32 in in IN cord-001446-mpuovmeb 91 33 processing processing NN cord-001446-mpuovmeb 91 34 and and CC cord-001446-mpuovmeb 91 35 storage storage NN cord-001446-mpuovmeb 91 36 were be VBD cord-001446-mpuovmeb 91 37 present present JJ cord-001446-mpuovmeb 91 38 . . . cord-001446-mpuovmeb 92 1 To to TO cord-001446-mpuovmeb 92 2 address address VB cord-001446-mpuovmeb 92 3 this this DT cord-001446-mpuovmeb 92 4 , , , cord-001446-mpuovmeb 92 5 we -PRON- PRP cord-001446-mpuovmeb 92 6 assayed assay VBD cord-001446-mpuovmeb 92 7 serum serum NN cord-001446-mpuovmeb 92 8 and and CC cord-001446-mpuovmeb 92 9 heparin heparin NN cord-001446-mpuovmeb 92 10 plasma plasma NN cord-001446-mpuovmeb 92 11 without without IN cord-001446-mpuovmeb 92 12 platelets platelet NNS cord-001446-mpuovmeb 92 13 immediately immediately RB cord-001446-mpuovmeb 92 14 after after IN cord-001446-mpuovmeb 92 15 processing process VBG cord-001446-mpuovmeb 92 16 or or CC cord-001446-mpuovmeb 92 17 after after IN cord-001446-mpuovmeb 92 18 storage storage NN cord-001446-mpuovmeb 92 19 at at IN cord-001446-mpuovmeb 92 20 4uC 4uc CD cord-001446-mpuovmeb 92 21 , , , cord-001446-mpuovmeb 92 22 220uC 220uc CD cord-001446-mpuovmeb 92 23 , , , cord-001446-mpuovmeb 92 24 or or CC cord-001446-mpuovmeb 92 25 280uC 280uc CD cord-001446-mpuovmeb 93 1 ( ( -LRB- cord-001446-mpuovmeb 93 2 Figure Figure NNP cord-001446-mpuovmeb 93 3 7 7 CD cord-001446-mpuovmeb 93 4 ) ) -RRB- cord-001446-mpuovmeb 93 5 ; ; : cord-001446-mpuovmeb 93 6 there there EX cord-001446-mpuovmeb 93 7 were be VBD cord-001446-mpuovmeb 93 8 no no DT cord-001446-mpuovmeb 93 9 significant significant JJ cord-001446-mpuovmeb 93 10 differences difference NNS cord-001446-mpuovmeb 93 11 between between IN cord-001446-mpuovmeb 93 12 conditions condition NNS cord-001446-mpuovmeb 93 13 . . . cord-001446-mpuovmeb 94 1 Additionally additionally RB cord-001446-mpuovmeb 94 2 , , , cord-001446-mpuovmeb 94 3 there there EX cord-001446-mpuovmeb 94 4 were be VBD cord-001446-mpuovmeb 94 5 only only RB cord-001446-mpuovmeb 94 6 subtle subtle JJ cord-001446-mpuovmeb 94 7 differences difference NNS cord-001446-mpuovmeb 94 8 between between IN cord-001446-mpuovmeb 94 9 a a DT cord-001446-mpuovmeb 94 10 sample sample NN cord-001446-mpuovmeb 94 11 stored store VBN cord-001446-mpuovmeb 94 12 at at IN cord-001446-mpuovmeb 94 13 220uC 220uc NN cord-001446-mpuovmeb 94 14 and and CC cord-001446-mpuovmeb 94 15 2 2 CD cord-001446-mpuovmeb 94 16 80uC 80uc CD cord-001446-mpuovmeb 94 17 , , , cord-001446-mpuovmeb 94 18 and and CC cord-001446-mpuovmeb 94 19 depending depend VBG cord-001446-mpuovmeb 94 20 on on IN cord-001446-mpuovmeb 94 21 whether whether IN cord-001446-mpuovmeb 94 22 the the DT cord-001446-mpuovmeb 94 23 sample sample NN cord-001446-mpuovmeb 94 24 went go VBD cord-001446-mpuovmeb 94 25 through through IN cord-001446-mpuovmeb 94 26 a a DT cord-001446-mpuovmeb 94 27 freeze/ freeze/ NN cord-001446-mpuovmeb 94 28 thaw thaw NN cord-001446-mpuovmeb 94 29 ( ( -LRB- cord-001446-mpuovmeb 94 30 FT FT NNP cord-001446-mpuovmeb 94 31 ) ) -RRB- cord-001446-mpuovmeb 94 32 cycle cycle NN cord-001446-mpuovmeb 94 33 , , , cord-001446-mpuovmeb 94 34 contained contain VBD cord-001446-mpuovmeb 94 35 platelets platelet NNS cord-001446-mpuovmeb 94 36 or or CC cord-001446-mpuovmeb 94 37 not not RB cord-001446-mpuovmeb 94 38 , , , cord-001446-mpuovmeb 94 39 or or CC cord-001446-mpuovmeb 94 40 was be VBD cord-001446-mpuovmeb 94 41 spun spin VBN cord-001446-mpuovmeb 94 42 after after IN cord-001446-mpuovmeb 94 43 thawing thaw VBG cord-001446-mpuovmeb 94 44 to to TO cord-001446-mpuovmeb 94 45 separate separate VB cord-001446-mpuovmeb 94 46 any any DT cord-001446-mpuovmeb 94 47 precipitates precipitate NNS cord-001446-mpuovmeb 94 48 / / SYM cord-001446-mpuovmeb 94 49 debris debris NN cord-001446-mpuovmeb 94 50 ( ( -LRB- cord-001446-mpuovmeb 94 51 data datum NNS cord-001446-mpuovmeb 94 52 not not RB cord-001446-mpuovmeb 94 53 shown show VBN cord-001446-mpuovmeb 94 54 ) ) -RRB- cord-001446-mpuovmeb 94 55 . . . cord-001446-mpuovmeb 95 1 SP SP NNP cord-001446-mpuovmeb 95 2 - - HYPH cord-001446-mpuovmeb 95 3 D d JJ cord-001446-mpuovmeb 95 4 concentrations concentration NNS cord-001446-mpuovmeb 95 5 of of IN cord-001446-mpuovmeb 95 6 samples sample NNS cord-001446-mpuovmeb 95 7 stored store VBN cord-001446-mpuovmeb 95 8 at at IN cord-001446-mpuovmeb 95 9 220uC 220uc NN cord-001446-mpuovmeb 95 10 and and CC cord-001446-mpuovmeb 95 11 280uC 280uc CD cord-001446-mpuovmeb 95 12 for for IN cord-001446-mpuovmeb 95 13 two two CD cord-001446-mpuovmeb 95 14 weeks week NNS cord-001446-mpuovmeb 95 15 were be VBD cord-001446-mpuovmeb 95 16 not not RB cord-001446-mpuovmeb 95 17 different different JJ cord-001446-mpuovmeb 95 18 from from IN cord-001446-mpuovmeb 95 19 the the DT cord-001446-mpuovmeb 95 20 same same JJ cord-001446-mpuovmeb 95 21 samples sample NNS cord-001446-mpuovmeb 95 22 at at IN cord-001446-mpuovmeb 95 23 one one CD cord-001446-mpuovmeb 95 24 week week NN cord-001446-mpuovmeb 96 1 ( ( -LRB- cord-001446-mpuovmeb 96 2 data datum NNS cord-001446-mpuovmeb 96 3 not not RB cord-001446-mpuovmeb 96 4 shown show VBN cord-001446-mpuovmeb 96 5 ) ) -RRB- cord-001446-mpuovmeb 96 6 . . . cord-001446-mpuovmeb 97 1 This this DT cord-001446-mpuovmeb 97 2 study study NN cord-001446-mpuovmeb 97 3 provides provide VBZ cord-001446-mpuovmeb 97 4 experimental experimental JJ cord-001446-mpuovmeb 97 5 evidence evidence NN cord-001446-mpuovmeb 97 6 that that IN cord-001446-mpuovmeb 97 7 variations variation NNS cord-001446-mpuovmeb 97 8 in in IN cord-001446-mpuovmeb 97 9 the the DT cord-001446-mpuovmeb 97 10 anticoagulant anticoagulant NN cord-001446-mpuovmeb 97 11 used use VBN cord-001446-mpuovmeb 97 12 and and CC cord-001446-mpuovmeb 97 13 ELISA ELISA NNP cord-001446-mpuovmeb 97 14 configuration configuration NN cord-001446-mpuovmeb 97 15 can can MD cord-001446-mpuovmeb 97 16 have have VB cord-001446-mpuovmeb 97 17 dramatic dramatic JJ cord-001446-mpuovmeb 97 18 effects effect NNS cord-001446-mpuovmeb 97 19 upon upon IN cord-001446-mpuovmeb 97 20 the the DT cord-001446-mpuovmeb 97 21 measured measure VBN cord-001446-mpuovmeb 97 22 SP SP NNP cord-001446-mpuovmeb 97 23 - - HYPH cord-001446-mpuovmeb 97 24 D d JJ cord-001446-mpuovmeb 97 25 level level NN cord-001446-mpuovmeb 97 26 . . . cord-001446-mpuovmeb 98 1 Storage storage NN cord-001446-mpuovmeb 98 2 and and CC cord-001446-mpuovmeb 98 3 processing processing NN cord-001446-mpuovmeb 98 4 of of IN cord-001446-mpuovmeb 98 5 samples sample NNS cord-001446-mpuovmeb 98 6 as as RB cord-001446-mpuovmeb 98 7 well well RB cord-001446-mpuovmeb 98 8 as as IN cord-001446-mpuovmeb 98 9 diluent diluent NN cord-001446-mpuovmeb 98 10 used use VBN cord-001446-mpuovmeb 98 11 for for IN cord-001446-mpuovmeb 98 12 the the DT cord-001446-mpuovmeb 98 13 standard standard NN cord-001446-mpuovmeb 98 14 have have VBP cord-001446-mpuovmeb 98 15 minor minor JJ cord-001446-mpuovmeb 98 16 effects effect NNS cord-001446-mpuovmeb 98 17 on on IN cord-001446-mpuovmeb 98 18 the the DT cord-001446-mpuovmeb 98 19 level level NN cord-001446-mpuovmeb 98 20 of of IN cord-001446-mpuovmeb 98 21 SP SP NNP cord-001446-mpuovmeb 98 22 - - HYPH cord-001446-mpuovmeb 98 23 D D NNP cord-001446-mpuovmeb 98 24 extrapolated extrapolate VBN cord-001446-mpuovmeb 98 25 by by IN cord-001446-mpuovmeb 98 26 ELISA ELISA NNP cord-001446-mpuovmeb 98 27 . . . cord-001446-mpuovmeb 99 1 Although although IN cord-001446-mpuovmeb 99 2 these these DT cord-001446-mpuovmeb 99 3 results result NNS cord-001446-mpuovmeb 99 4 may may MD cord-001446-mpuovmeb 99 5 partially partially RB cord-001446-mpuovmeb 99 6 explain explain VB cord-001446-mpuovmeb 99 7 the the DT cord-001446-mpuovmeb 99 8 variations variation NNS cord-001446-mpuovmeb 99 9 seen see VBN cord-001446-mpuovmeb 99 10 in in IN cord-001446-mpuovmeb 99 11 reported report VBN cord-001446-mpuovmeb 99 12 SP SP NNP cord-001446-mpuovmeb 99 13 - - HYPH cord-001446-mpuovmeb 99 14 D d JJ cord-001446-mpuovmeb 99 15 values value NNS cord-001446-mpuovmeb 99 16 in in IN cord-001446-mpuovmeb 99 17 the the DT cord-001446-mpuovmeb 99 18 blood blood NN cord-001446-mpuovmeb 99 19 , , , cord-001446-mpuovmeb 99 20 it -PRON- PRP cord-001446-mpuovmeb 99 21 is be VBZ cord-001446-mpuovmeb 99 22 important important JJ cord-001446-mpuovmeb 99 23 to to TO cord-001446-mpuovmeb 99 24 note note VB cord-001446-mpuovmeb 99 25 the the DT cord-001446-mpuovmeb 99 26 caveats caveat NNS cord-001446-mpuovmeb 99 27 associated associate VBN cord-001446-mpuovmeb 99 28 with with IN cord-001446-mpuovmeb 99 29 this this DT cord-001446-mpuovmeb 99 30 review review NN cord-001446-mpuovmeb 99 31 of of IN cord-001446-mpuovmeb 99 32 the the DT cord-001446-mpuovmeb 99 33 literature literature NN cord-001446-mpuovmeb 99 34 . . . cord-001446-mpuovmeb 100 1 For for IN cord-001446-mpuovmeb 100 2 the the DT cord-001446-mpuovmeb 100 3 comparison comparison NN cord-001446-mpuovmeb 100 4 of of IN cord-001446-mpuovmeb 100 5 healthy healthy JJ cord-001446-mpuovmeb 100 6 control control NN cord-001446-mpuovmeb 100 7 groups group NNS cord-001446-mpuovmeb 100 8 amongst amongst IN cord-001446-mpuovmeb 100 9 various various JJ cord-001446-mpuovmeb 100 10 studies study NNS cord-001446-mpuovmeb 100 11 , , , cord-001446-mpuovmeb 100 12 it -PRON- PRP cord-001446-mpuovmeb 100 13 is be VBZ cord-001446-mpuovmeb 100 14 possible possible JJ cord-001446-mpuovmeb 100 15 that that IN cord-001446-mpuovmeb 100 16 differences difference NNS cord-001446-mpuovmeb 100 17 in in IN cord-001446-mpuovmeb 100 18 ethnic ethnic JJ cord-001446-mpuovmeb 100 19 background background NN cord-001446-mpuovmeb 100 20 and/or and/or CC cord-001446-mpuovmeb 100 21 geographical geographical JJ cord-001446-mpuovmeb 100 22 location location NN cord-001446-mpuovmeb 100 23 from from IN cord-001446-mpuovmeb 100 24 which which WDT cord-001446-mpuovmeb 100 25 subjects subject NNS cord-001446-mpuovmeb 100 26 were be VBD cord-001446-mpuovmeb 100 27 recruited recruit VBN cord-001446-mpuovmeb 100 28 may may MD cord-001446-mpuovmeb 100 29 contribute contribute VB cord-001446-mpuovmeb 100 30 to to IN cord-001446-mpuovmeb 100 31 the the DT cord-001446-mpuovmeb 100 32 variations variation NNS cord-001446-mpuovmeb 100 33 seen see VBN cord-001446-mpuovmeb 100 34 when when WRB cord-001446-mpuovmeb 100 35 the the DT cord-001446-mpuovmeb 100 36 same same JJ cord-001446-mpuovmeb 100 37 ELISA ELISA NNP cord-001446-mpuovmeb 100 38 configuration configuration NN cord-001446-mpuovmeb 100 39 was be VBD cord-001446-mpuovmeb 100 40 employed employ VBN cord-001446-mpuovmeb 100 41 , , , cord-001446-mpuovmeb 100 42 as as IN cord-001446-mpuovmeb 100 43 could could MD cord-001446-mpuovmeb 100 44 the the DT cord-001446-mpuovmeb 100 45 type type NN cord-001446-mpuovmeb 100 46 of of IN cord-001446-mpuovmeb 100 47 anticoagulant anticoagulant NN cord-001446-mpuovmeb 100 48 . . . cord-001446-mpuovmeb 101 1 However however RB cord-001446-mpuovmeb 101 2 , , , cord-001446-mpuovmeb 101 3 we -PRON- PRP cord-001446-mpuovmeb 101 4 would would MD cord-001446-mpuovmeb 101 5 expect expect VB cord-001446-mpuovmeb 101 6 the the DT cord-001446-mpuovmeb 101 7 range range NN cord-001446-mpuovmeb 101 8 of of IN cord-001446-mpuovmeb 101 9 samples sample NNS cord-001446-mpuovmeb 101 10 between between IN cord-001446-mpuovmeb 101 11 healthy healthy JJ cord-001446-mpuovmeb 101 12 populations population NNS cord-001446-mpuovmeb 101 13 of of IN cord-001446-mpuovmeb 101 14 different different JJ cord-001446-mpuovmeb 101 15 studies study NNS cord-001446-mpuovmeb 101 16 to to TO cord-001446-mpuovmeb 101 17 be be VB cord-001446-mpuovmeb 101 18 similar similar JJ cord-001446-mpuovmeb 101 19 . . . cord-001446-mpuovmeb 102 1 In in IN cord-001446-mpuovmeb 102 2 addition addition NN cord-001446-mpuovmeb 102 3 , , , cord-001446-mpuovmeb 102 4 assuming assume VBG cord-001446-mpuovmeb 102 5 that that IN cord-001446-mpuovmeb 102 6 an an DT cord-001446-mpuovmeb 102 7 appropriately appropriately RB cord-001446-mpuovmeb 102 8 matched match VBN cord-001446-mpuovmeb 102 9 control control NN cord-001446-mpuovmeb 102 10 population population NN cord-001446-mpuovmeb 102 11 was be VBD cord-001446-mpuovmeb 102 12 used use VBN cord-001446-mpuovmeb 102 13 for for IN cord-001446-mpuovmeb 102 14 comparison comparison NN cord-001446-mpuovmeb 102 15 to to IN cord-001446-mpuovmeb 102 16 the the DT cord-001446-mpuovmeb 102 17 disease disease NN cord-001446-mpuovmeb 102 18 population population NN cord-001446-mpuovmeb 102 19 , , , cord-001446-mpuovmeb 102 20 the the DT cord-001446-mpuovmeb 102 21 fold fold JJ cord-001446-mpuovmeb 102 22 change change NN cord-001446-mpuovmeb 102 23 between between IN cord-001446-mpuovmeb 102 24 healthy healthy JJ cord-001446-mpuovmeb 102 25 and and CC cord-001446-mpuovmeb 102 26 disease disease NN cord-001446-mpuovmeb 102 27 should should MD cord-001446-mpuovmeb 102 28 be be VB cord-001446-mpuovmeb 102 29 more more RBR cord-001446-mpuovmeb 102 30 similar similar JJ cord-001446-mpuovmeb 102 31 than than IN cord-001446-mpuovmeb 102 32 what what WP cord-001446-mpuovmeb 102 33 was be VBD cord-001446-mpuovmeb 102 34 observed observe VBN cord-001446-mpuovmeb 102 35 in in IN cord-001446-mpuovmeb 102 36 the the DT cord-001446-mpuovmeb 102 37 literature literature NN cord-001446-mpuovmeb 102 38 . . . cord-001446-mpuovmeb 103 1 Measuring measure VBG cord-001446-mpuovmeb 103 2 SP SP NNP cord-001446-mpuovmeb 103 3 - - HYPH cord-001446-mpuovmeb 103 4 D D NNP cord-001446-mpuovmeb 103 5 by by IN cord-001446-mpuovmeb 103 6 ELISA ELISA NNP cord-001446-mpuovmeb 103 7 presents present VBZ cord-001446-mpuovmeb 103 8 a a DT cord-001446-mpuovmeb 103 9 problem problem NN cord-001446-mpuovmeb 103 10 due due IN cord-001446-mpuovmeb 103 11 to to IN cord-001446-mpuovmeb 103 12 its -PRON- PRP$ cord-001446-mpuovmeb 103 13 multimeric multimeric JJ cord-001446-mpuovmeb 103 14 structure structure NN cord-001446-mpuovmeb 103 15 . . . cord-001446-mpuovmeb 104 1 For for IN cord-001446-mpuovmeb 104 2 each each DT cord-001446-mpuovmeb 104 3 molecule molecule NN cord-001446-mpuovmeb 104 4 ( ( -LRB- cord-001446-mpuovmeb 104 5 a a DT cord-001446-mpuovmeb 104 6 complete complete JJ cord-001446-mpuovmeb 104 7 dodecamer dodecamer NN cord-001446-mpuovmeb 104 8 ) ) -RRB- cord-001446-mpuovmeb 104 9 of of IN cord-001446-mpuovmeb 104 10 multimerized multimerized JJ cord-001446-mpuovmeb 104 11 protein protein NN cord-001446-mpuovmeb 104 12 , , , cord-001446-mpuovmeb 104 13 there there EX cord-001446-mpuovmeb 104 14 are be VBP cord-001446-mpuovmeb 104 15 at at RB cord-001446-mpuovmeb 104 16 least least RBS cord-001446-mpuovmeb 104 17 12 12 CD cord-001446-mpuovmeb 104 18 of of IN cord-001446-mpuovmeb 104 19 the the DT cord-001446-mpuovmeb 104 20 same same JJ cord-001446-mpuovmeb 104 21 epitopes epitope NNS cord-001446-mpuovmeb 104 22 present present JJ cord-001446-mpuovmeb 104 23 . . . cord-001446-mpuovmeb 105 1 Due due IN cord-001446-mpuovmeb 105 2 to to IN cord-001446-mpuovmeb 105 3 this this DT cord-001446-mpuovmeb 105 4 property property NN cord-001446-mpuovmeb 105 5 , , , cord-001446-mpuovmeb 105 6 it -PRON- PRP cord-001446-mpuovmeb 105 7 is be VBZ cord-001446-mpuovmeb 105 8 not not RB cord-001446-mpuovmeb 105 9 necessary necessary JJ cord-001446-mpuovmeb 105 10 to to TO cord-001446-mpuovmeb 105 11 use use VB cord-001446-mpuovmeb 105 12 discrete discrete JJ cord-001446-mpuovmeb 105 13 antibodies antibody NNS cord-001446-mpuovmeb 105 14 in in IN cord-001446-mpuovmeb 105 15 a a DT cord-001446-mpuovmeb 105 16 sandwich sandwich NN cord-001446-mpuovmeb 105 17 ELISA ELISA NNP cord-001446-mpuovmeb 105 18 format format NN cord-001446-mpuovmeb 105 19 to to TO cord-001446-mpuovmeb 105 20 capture capture VB cord-001446-mpuovmeb 105 21 and and CC cord-001446-mpuovmeb 105 22 then then RB cord-001446-mpuovmeb 105 23 detect detect VB cord-001446-mpuovmeb 105 24 SP SP NNP cord-001446-mpuovmeb 105 25 - - HYPH cord-001446-mpuovmeb 105 26 D D NNP cord-001446-mpuovmeb 105 27 ; ; : cord-001446-mpuovmeb 105 28 even even RB cord-001446-mpuovmeb 105 29 the the DT cord-001446-mpuovmeb 105 30 same same JJ cord-001446-mpuovmeb 105 31 monoclonal monoclonal JJ cord-001446-mpuovmeb 105 32 antibody antibody NN cord-001446-mpuovmeb 105 33 could could MD cord-001446-mpuovmeb 105 34 be be VB cord-001446-mpuovmeb 105 35 used use VBN cord-001446-mpuovmeb 105 36 for for IN cord-001446-mpuovmeb 105 37 both both DT cord-001446-mpuovmeb 105 38 . . . cord-001446-mpuovmeb 106 1 However however RB cord-001446-mpuovmeb 106 2 , , , cord-001446-mpuovmeb 106 3 this this DT cord-001446-mpuovmeb 106 4 may may MD cord-001446-mpuovmeb 106 5 cause cause VB cord-001446-mpuovmeb 106 6 a a DT cord-001446-mpuovmeb 106 7 difference difference NN cord-001446-mpuovmeb 106 8 in in IN cord-001446-mpuovmeb 106 9 read read VBN cord-001446-mpuovmeb 106 10 out out RP cord-001446-mpuovmeb 106 11 compared compare VBN cord-001446-mpuovmeb 106 12 to to IN cord-001446-mpuovmeb 106 13 using use VBG cord-001446-mpuovmeb 106 14 antibodies antibody NNS cord-001446-mpuovmeb 106 15 that that WDT cord-001446-mpuovmeb 106 16 detect detect VBP cord-001446-mpuovmeb 106 17 different different JJ cord-001446-mpuovmeb 106 18 epitopes epitope NNS cord-001446-mpuovmeb 106 19 , , , cord-001446-mpuovmeb 106 20 due due IN cord-001446-mpuovmeb 106 21 to to IN cord-001446-mpuovmeb 106 22 the the DT cord-001446-mpuovmeb 106 23 fact fact NN cord-001446-mpuovmeb 106 24 that that IN cord-001446-mpuovmeb 106 25 the the DT cord-001446-mpuovmeb 106 26 degree degree NN cord-001446-mpuovmeb 106 27 of of IN cord-001446-mpuovmeb 106 28 multimerization multimerization NN cord-001446-mpuovmeb 106 29 has have VBZ cord-001446-mpuovmeb 106 30 been be VBN cord-001446-mpuovmeb 106 31 shown show VBN cord-001446-mpuovmeb 106 32 to to TO cord-001446-mpuovmeb 106 33 vary vary VB cord-001446-mpuovmeb 106 34 in in IN cord-001446-mpuovmeb 106 35 the the DT cord-001446-mpuovmeb 106 36 lungs lung NNS cord-001446-mpuovmeb 106 37 during during IN cord-001446-mpuovmeb 106 38 different different JJ cord-001446-mpuovmeb 106 39 disease disease NN cord-001446-mpuovmeb 106 40 states state NNS cord-001446-mpuovmeb 106 41 [ [ -LRB- cord-001446-mpuovmeb 106 42 92 92 CD cord-001446-mpuovmeb 106 43 ] ] -RRB- cord-001446-mpuovmeb 106 44 and and CC cord-001446-mpuovmeb 106 45 using use VBG cord-001446-mpuovmeb 106 46 the the DT cord-001446-mpuovmeb 106 47 same same JJ cord-001446-mpuovmeb 106 48 monoclonal monoclonal JJ cord-001446-mpuovmeb 106 49 antibody antibody NN cord-001446-mpuovmeb 106 50 would would MD cord-001446-mpuovmeb 106 51 fail fail VB cord-001446-mpuovmeb 106 52 to to TO cord-001446-mpuovmeb 106 53 detect detect VB cord-001446-mpuovmeb 106 54 a a DT cord-001446-mpuovmeb 106 55 monomer monomer NN cord-001446-mpuovmeb 106 56 . . . cord-001446-mpuovmeb 107 1 Even even RB cord-001446-mpuovmeb 107 2 using use VBG cord-001446-mpuovmeb 107 3 two two CD cord-001446-mpuovmeb 107 4 monoclonals monoclonal NNS cord-001446-mpuovmeb 107 5 that that WDT cord-001446-mpuovmeb 107 6 recognize recognize VBP cord-001446-mpuovmeb 107 7 distinct distinct JJ cord-001446-mpuovmeb 107 8 epitopes epitope NNS cord-001446-mpuovmeb 107 9 to to TO cord-001446-mpuovmeb 107 10 measure measure VB cord-001446-mpuovmeb 107 11 SP SP NNP cord-001446-mpuovmeb 107 12 - - HYPH cord-001446-mpuovmeb 107 13 D D NNP cord-001446-mpuovmeb 107 14 in in IN cord-001446-mpuovmeb 107 15 its -PRON- PRP$ cord-001446-mpuovmeb 107 16 native native JJ cord-001446-mpuovmeb 107 17 state state NN cord-001446-mpuovmeb 107 18 would would MD cord-001446-mpuovmeb 107 19 be be VB cord-001446-mpuovmeb 107 20 confounded confound VBN cord-001446-mpuovmeb 107 21 by by IN cord-001446-mpuovmeb 107 22 differences difference NNS cord-001446-mpuovmeb 107 23 in in IN cord-001446-mpuovmeb 107 24 the the DT cord-001446-mpuovmeb 107 25 degree degree NN cord-001446-mpuovmeb 107 26 of of IN cord-001446-mpuovmeb 107 27 multimerization multimerization NN cord-001446-mpuovmeb 107 28 . . . cord-001446-mpuovmeb 108 1 For for IN cord-001446-mpuovmeb 108 2 example example NN cord-001446-mpuovmeb 108 3 , , , cord-001446-mpuovmeb 108 4 if if IN cord-001446-mpuovmeb 108 5 an an DT cord-001446-mpuovmeb 108 6 antibody antibody NN cord-001446-mpuovmeb 108 7 against against IN cord-001446-mpuovmeb 108 8 the the DT cord-001446-mpuovmeb 108 9 carbohydrate carbohydrate NN cord-001446-mpuovmeb 108 10 recognition recognition NN cord-001446-mpuovmeb 108 11 domain domain NN cord-001446-mpuovmeb 108 12 of of IN cord-001446-mpuovmeb 108 13 SP SP NNP cord-001446-mpuovmeb 108 14 - - HYPH cord-001446-mpuovmeb 108 15 D D NNP cord-001446-mpuovmeb 108 16 was be VBD cord-001446-mpuovmeb 108 17 used use VBN cord-001446-mpuovmeb 108 18 to to TO cord-001446-mpuovmeb 108 19 capture capture VB cord-001446-mpuovmeb 108 20 and and CC cord-001446-mpuovmeb 108 21 an an DT cord-001446-mpuovmeb 108 22 antibody antibody NN cord-001446-mpuovmeb 108 23 against against IN cord-001446-mpuovmeb 108 24 the the DT cord-001446-mpuovmeb 108 25 neck neck NN cord-001446-mpuovmeb 108 26 region region NN cord-001446-mpuovmeb 108 27 of of IN cord-001446-mpuovmeb 108 28 SP SP NNP cord-001446-mpuovmeb 108 29 - - HYPH cord-001446-mpuovmeb 108 30 D D NNP cord-001446-mpuovmeb 108 31 was be VBD cord-001446-mpuovmeb 108 32 used use VBN cord-001446-mpuovmeb 108 33 to to TO cord-001446-mpuovmeb 108 34 detect detect VB cord-001446-mpuovmeb 108 35 , , , cord-001446-mpuovmeb 108 36 a a DT cord-001446-mpuovmeb 108 37 single single JJ cord-001446-mpuovmeb 108 38 , , , cord-001446-mpuovmeb 108 39 captured capture VBN cord-001446-mpuovmeb 108 40 monomer monomer NN cord-001446-mpuovmeb 108 41 of of IN cord-001446-mpuovmeb 108 42 SP SP NNP cord-001446-mpuovmeb 108 43 - - HYPH cord-001446-mpuovmeb 108 44 D D NNP cord-001446-mpuovmeb 108 45 would would MD cord-001446-mpuovmeb 108 46 be be VB cord-001446-mpuovmeb 108 47 able able JJ cord-001446-mpuovmeb 108 48 to to TO cord-001446-mpuovmeb 108 49 bind bind VB cord-001446-mpuovmeb 108 50 a a DT cord-001446-mpuovmeb 108 51 single single JJ cord-001446-mpuovmeb 108 52 anti anti JJ cord-001446-mpuovmeb 108 53 - - JJ cord-001446-mpuovmeb 108 54 neck neck JJ cord-001446-mpuovmeb 108 55 antibody antibody NN cord-001446-mpuovmeb 108 56 . . . cord-001446-mpuovmeb 109 1 However however RB cord-001446-mpuovmeb 109 2 , , , cord-001446-mpuovmeb 109 3 a a DT cord-001446-mpuovmeb 109 4 single single JJ cord-001446-mpuovmeb 109 5 , , , cord-001446-mpuovmeb 109 6 captured capture VBN cord-001446-mpuovmeb 109 7 dodecamer dodecamer NNP cord-001446-mpuovmeb 109 8 would would MD cord-001446-mpuovmeb 109 9 be be VB cord-001446-mpuovmeb 109 10 able able JJ cord-001446-mpuovmeb 109 11 to to TO cord-001446-mpuovmeb 109 12 bind bind VB cord-001446-mpuovmeb 109 13 12 12 CD cord-001446-mpuovmeb 109 14 anti anti JJ cord-001446-mpuovmeb 109 15 - - JJ cord-001446-mpuovmeb 109 16 neck neck JJ cord-001446-mpuovmeb 109 17 antibodies antibody NNS cord-001446-mpuovmeb 109 18 . . . cord-001446-mpuovmeb 110 1 In in IN cord-001446-mpuovmeb 110 2 order order NN cord-001446-mpuovmeb 110 3 to to TO cord-001446-mpuovmeb 110 4 accurately accurately RB cord-001446-mpuovmeb 110 5 establish establish VB cord-001446-mpuovmeb 110 6 absolute absolute JJ cord-001446-mpuovmeb 110 7 concentrations concentration NNS cord-001446-mpuovmeb 110 8 by by IN cord-001446-mpuovmeb 110 9 ELISA ELISA NNP cord-001446-mpuovmeb 110 10 , , , cord-001446-mpuovmeb 110 11 it -PRON- PRP cord-001446-mpuovmeb 110 12 would would MD cord-001446-mpuovmeb 110 13 be be VB cord-001446-mpuovmeb 110 14 important important JJ cord-001446-mpuovmeb 110 15 that that IN cord-001446-mpuovmeb 110 16 the the DT cord-001446-mpuovmeb 110 17 multimeric multimeric JJ cord-001446-mpuovmeb 110 18 structure structure NN cord-001446-mpuovmeb 110 19 of of IN cord-001446-mpuovmeb 110 20 the the DT cord-001446-mpuovmeb 110 21 standard standard NN cord-001446-mpuovmeb 110 22 was be VBD cord-001446-mpuovmeb 110 23 equivalent equivalent JJ cord-001446-mpuovmeb 110 24 to to IN cord-001446-mpuovmeb 110 25 that that DT cord-001446-mpuovmeb 110 26 of of IN cord-001446-mpuovmeb 110 27 the the DT cord-001446-mpuovmeb 110 28 samples sample NNS cord-001446-mpuovmeb 110 29 , , , cord-001446-mpuovmeb 110 30 as as IN cord-001446-mpuovmeb 110 31 there there EX cord-001446-mpuovmeb 110 32 could could MD cord-001446-mpuovmeb 110 33 be be VB cord-001446-mpuovmeb 110 34 differences difference NNS cord-001446-mpuovmeb 110 35 in in IN cord-001446-mpuovmeb 110 36 antigen antigen NN cord-001446-mpuovmeb 110 37 binding bind VBG cord-001446-mpuovmeb 110 38 in in IN cord-001446-mpuovmeb 110 39 higher high JJR cord-001446-mpuovmeb 110 40 order order NN cord-001446-mpuovmeb 110 41 multimers multimer NNS cord-001446-mpuovmeb 110 42 due due JJ cord-001446-mpuovmeb 110 43 to to IN cord-001446-mpuovmeb 110 44 steric steric JJ cord-001446-mpuovmeb 110 45 hinderance hinderance NN cord-001446-mpuovmeb 110 46 . . . cord-001446-mpuovmeb 111 1 Unfortunately unfortunately RB cord-001446-mpuovmeb 111 2 , , , cord-001446-mpuovmeb 111 3 we -PRON- PRP cord-001446-mpuovmeb 111 4 did do VBD cord-001446-mpuovmeb 111 5 not not RB cord-001446-mpuovmeb 111 6 have have VB cord-001446-mpuovmeb 111 7 the the DT cord-001446-mpuovmeb 111 8 necessary necessary JJ cord-001446-mpuovmeb 111 9 resources resource NNS cord-001446-mpuovmeb 111 10 to to TO cord-001446-mpuovmeb 111 11 examine examine VB cord-001446-mpuovmeb 111 12 the the DT cord-001446-mpuovmeb 111 13 influence influence NN cord-001446-mpuovmeb 111 14 of of IN cord-001446-mpuovmeb 111 15 the the DT cord-001446-mpuovmeb 111 16 degree degree NN cord-001446-mpuovmeb 111 17 of of IN cord-001446-mpuovmeb 111 18 multimerization multimerization NN cord-001446-mpuovmeb 111 19 on on IN cord-001446-mpuovmeb 111 20 ELISA ELISA NNP cord-001446-mpuovmeb 111 21 measurements measurement NNS cord-001446-mpuovmeb 111 22 . . . cord-001446-mpuovmeb 112 1 In in IN cord-001446-mpuovmeb 112 2 addition addition NN cord-001446-mpuovmeb 112 3 to to IN cord-001446-mpuovmeb 112 4 the the DT cord-001446-mpuovmeb 112 5 possible possible JJ cord-001446-mpuovmeb 112 6 effects effect NNS cord-001446-mpuovmeb 112 7 caused cause VBN cord-001446-mpuovmeb 112 8 by by IN cord-001446-mpuovmeb 112 9 its -PRON- PRP$ cord-001446-mpuovmeb 112 10 multimeric multimeric JJ cord-001446-mpuovmeb 112 11 nature nature NN cord-001446-mpuovmeb 112 12 , , , cord-001446-mpuovmeb 112 13 there there EX cord-001446-mpuovmeb 112 14 is be VBZ cord-001446-mpuovmeb 112 15 evidence evidence NN cord-001446-mpuovmeb 112 16 in in IN cord-001446-mpuovmeb 112 17 the the DT cord-001446-mpuovmeb 112 18 literature literature NN cord-001446-mpuovmeb 112 19 to to IN cord-001446-mpuovmeb 112 20 variable variable JJ cord-001446-mpuovmeb 112 21 posttranslational posttranslational JJ cord-001446-mpuovmeb 112 22 modifications modification NNS cord-001446-mpuovmeb 112 23 of of IN cord-001446-mpuovmeb 112 24 SP SP NNP cord-001446-mpuovmeb 112 25 - - HYPH cord-001446-mpuovmeb 112 26 D D NNP cord-001446-mpuovmeb 112 27 in in IN cord-001446-mpuovmeb 112 28 native native JJ cord-001446-mpuovmeb 112 29 samples sample NNS cord-001446-mpuovmeb 112 30 . . . cord-001446-mpuovmeb 113 1 These these DT cord-001446-mpuovmeb 113 2 modifications modification NNS cord-001446-mpuovmeb 113 3 may may MD cord-001446-mpuovmeb 113 4 , , , cord-001446-mpuovmeb 113 5 in in IN cord-001446-mpuovmeb 113 6 fact fact NN cord-001446-mpuovmeb 113 7 , , , cord-001446-mpuovmeb 113 8 mask mask VB cord-001446-mpuovmeb 113 9 the the DT cord-001446-mpuovmeb 113 10 epitope epitope NN cord-001446-mpuovmeb 113 11 recognized recognize VBN cord-001446-mpuovmeb 113 12 by by IN cord-001446-mpuovmeb 113 13 an an DT cord-001446-mpuovmeb 113 14 ELISA ELISA NNP cord-001446-mpuovmeb 113 15 antibody antibody NN cord-001446-mpuovmeb 113 16 . . . cord-001446-mpuovmeb 114 1 This this DT cord-001446-mpuovmeb 114 2 may may MD cord-001446-mpuovmeb 114 3 account account VB cord-001446-mpuovmeb 114 4 for for IN cord-001446-mpuovmeb 114 5 one one CD cord-001446-mpuovmeb 114 6 of of IN cord-001446-mpuovmeb 114 7 the the DT cord-001446-mpuovmeb 114 8 largest large JJS cord-001446-mpuovmeb 114 9 differences difference NNS cord-001446-mpuovmeb 114 10 seen see VBN cord-001446-mpuovmeb 114 11 in in IN cord-001446-mpuovmeb 114 12 the the DT cord-001446-mpuovmeb 114 13 reported report VBN cord-001446-mpuovmeb 114 14 ELISA ELISA NNP cord-001446-mpuovmeb 114 15 measurements measurement NNS cord-001446-mpuovmeb 114 16 of of IN cord-001446-mpuovmeb 114 17 SP SP NNP cord-001446-mpuovmeb 114 18 - - HYPH cord-001446-mpuovmeb 114 19 D D NNP cord-001446-mpuovmeb 114 20 in in IN cord-001446-mpuovmeb 114 21 serum serum NN cord-001446-mpuovmeb 114 22 / / SYM cord-001446-mpuovmeb 114 23 plasma plasma NN cord-001446-mpuovmeb 114 24 , , , cord-001446-mpuovmeb 114 25 as as IN cord-001446-mpuovmeb 114 26 the the DT cord-001446-mpuovmeb 114 27 highest high JJS cord-001446-mpuovmeb 114 28 concentrations concentration NNS cord-001446-mpuovmeb 114 29 of of IN cord-001446-mpuovmeb 114 30 SP SP NNP cord-001446-mpuovmeb 114 31 - - HYPH cord-001446-mpuovmeb 114 32 D D NNP cord-001446-mpuovmeb 114 33 came come VBD cord-001446-mpuovmeb 114 34 from from IN cord-001446-mpuovmeb 114 35 the the DT cord-001446-mpuovmeb 114 36 non non NN cord-001446-mpuovmeb 114 37 - - JJ cord-001446-mpuovmeb 114 38 commercially commercially RB cord-001446-mpuovmeb 114 39 available available JJ cord-001446-mpuovmeb 114 40 ELISA ELISA NNP cord-001446-mpuovmeb 114 41 which which WDT cord-001446-mpuovmeb 114 42 used use VBD cord-001446-mpuovmeb 114 43 purified purify VBN cord-001446-mpuovmeb 114 44 , , , cord-001446-mpuovmeb 114 45 native native JJ cord-001446-mpuovmeb 114 46 SP SP NNP cord-001446-mpuovmeb 114 47 - - HYPH cord-001446-mpuovmeb 114 48 D D NNP cord-001446-mpuovmeb 114 49 as as IN cord-001446-mpuovmeb 114 50 a a DT cord-001446-mpuovmeb 114 51 standard standard NN cord-001446-mpuovmeb 114 52 ; ; : cord-001446-mpuovmeb 114 53 this this DT cord-001446-mpuovmeb 114 54 is be VBZ cord-001446-mpuovmeb 114 55 opposed opposed JJ cord-001446-mpuovmeb 114 56 to to IN cord-001446-mpuovmeb 114 57 almost almost RB cord-001446-mpuovmeb 114 58 all all DT cord-001446-mpuovmeb 114 59 others other NNS cord-001446-mpuovmeb 114 60 , , , cord-001446-mpuovmeb 114 61 which which WDT cord-001446-mpuovmeb 114 62 used use VBD cord-001446-mpuovmeb 114 63 recombinantly recombinantly RB cord-001446-mpuovmeb 114 64 expressed express VBD cord-001446-mpuovmeb 114 65 SP SP NNP cord-001446-mpuovmeb 114 66 - - HYPH cord-001446-mpuovmeb 114 67 D D NNP cord-001446-mpuovmeb 114 68 as as IN cord-001446-mpuovmeb 114 69 a a DT cord-001446-mpuovmeb 114 70 standard standard NN cord-001446-mpuovmeb 114 71 . . . cord-001446-mpuovmeb 115 1 Regardless regardless RB cord-001446-mpuovmeb 115 2 of of IN cord-001446-mpuovmeb 115 3 whether whether IN cord-001446-mpuovmeb 115 4 the the DT cord-001446-mpuovmeb 115 5 antibodies antibody NNS cord-001446-mpuovmeb 115 6 used use VBN cord-001446-mpuovmeb 115 7 were be VBD cord-001446-mpuovmeb 115 8 raised raise VBN cord-001446-mpuovmeb 115 9 against against IN cord-001446-mpuovmeb 115 10 recombinant recombinant JJ cord-001446-mpuovmeb 115 11 SP SP NNP cord-001446-mpuovmeb 115 12 - - HYPH cord-001446-mpuovmeb 115 13 D d JJ cord-001446-mpuovmeb 115 14 or or CC cord-001446-mpuovmeb 115 15 purified purify VBN cord-001446-mpuovmeb 115 16 native native JJ cord-001446-mpuovmeb 115 17 , , , cord-001446-mpuovmeb 115 18 because because IN cord-001446-mpuovmeb 115 19 the the DT cord-001446-mpuovmeb 115 20 post post JJ cord-001446-mpuovmeb 115 21 - - JJ cord-001446-mpuovmeb 115 22 translational translational JJ cord-001446-mpuovmeb 115 23 modifications modification NNS cord-001446-mpuovmeb 115 24 can can MD cord-001446-mpuovmeb 115 25 vary vary VB cord-001446-mpuovmeb 115 26 from from IN cord-001446-mpuovmeb 115 27 one one CD cord-001446-mpuovmeb 115 28 patient patient NN cord-001446-mpuovmeb 115 29 to to IN cord-001446-mpuovmeb 115 30 the the DT cord-001446-mpuovmeb 115 31 next next JJ cord-001446-mpuovmeb 115 32 , , , cord-001446-mpuovmeb 115 33 this this DT cord-001446-mpuovmeb 115 34 presents present VBZ cord-001446-mpuovmeb 115 35 a a DT cord-001446-mpuovmeb 115 36 significant significant JJ cord-001446-mpuovmeb 115 37 obstacle obstacle NN cord-001446-mpuovmeb 115 38 to to IN cord-001446-mpuovmeb 115 39 accurate accurate JJ cord-001446-mpuovmeb 115 40 measurements measurement NNS cord-001446-mpuovmeb 115 41 of of IN cord-001446-mpuovmeb 115 42 natural natural JJ cord-001446-mpuovmeb 115 43 SP SP NNP cord-001446-mpuovmeb 115 44 - - HYPH cord-001446-mpuovmeb 115 45 D D NNP cord-001446-mpuovmeb 115 46 using use VBG cord-001446-mpuovmeb 115 47 antibodies antibody NNS cord-001446-mpuovmeb 115 48 . . . cord-001446-mpuovmeb 116 1 The the DT cord-001446-mpuovmeb 116 2 results result NNS cord-001446-mpuovmeb 116 3 of of IN cord-001446-mpuovmeb 116 4 this this DT cord-001446-mpuovmeb 116 5 study study NN cord-001446-mpuovmeb 116 6 demonstrate demonstrate VBP cord-001446-mpuovmeb 116 7 the the DT cord-001446-mpuovmeb 116 8 influence influence NN cord-001446-mpuovmeb 116 9 that that IN cord-001446-mpuovmeb 116 10 the the DT cord-001446-mpuovmeb 116 11 antibody antibody NN cord-001446-mpuovmeb 116 12 may may MD cord-001446-mpuovmeb 116 13 have have VB cord-001446-mpuovmeb 116 14 on on IN cord-001446-mpuovmeb 116 15 the the DT cord-001446-mpuovmeb 116 16 SP SP NNP cord-001446-mpuovmeb 116 17 - - HYPH cord-001446-mpuovmeb 116 18 D d JJ cord-001446-mpuovmeb 116 19 concentration concentration NN cord-001446-mpuovmeb 116 20 as as IN cord-001446-mpuovmeb 116 21 measured measure VBN cord-001446-mpuovmeb 116 22 by by IN cord-001446-mpuovmeb 116 23 ELISA ELISA NNP cord-001446-mpuovmeb 116 24 . . . cord-001446-mpuovmeb 117 1 In in IN cord-001446-mpuovmeb 117 2 our -PRON- PRP$ cord-001446-mpuovmeb 117 3 experiments experiment NNS cord-001446-mpuovmeb 117 4 , , , cord-001446-mpuovmeb 117 5 it -PRON- PRP cord-001446-mpuovmeb 117 6 is be VBZ cord-001446-mpuovmeb 117 7 important important JJ cord-001446-mpuovmeb 117 8 to to TO cord-001446-mpuovmeb 117 9 note note VB cord-001446-mpuovmeb 117 10 that that IN cord-001446-mpuovmeb 117 11 the the DT cord-001446-mpuovmeb 117 12 same same JJ cord-001446-mpuovmeb 117 13 recombinant recombinant JJ cord-001446-mpuovmeb 117 14 standard standard NN cord-001446-mpuovmeb 117 15 and and CC cord-001446-mpuovmeb 117 16 human human JJ cord-001446-mpuovmeb 117 17 serum serum NN cord-001446-mpuovmeb 117 18 / / SYM cord-001446-mpuovmeb 117 19 plasma plasma NN cord-001446-mpuovmeb 117 20 samples sample NNS cord-001446-mpuovmeb 117 21 were be VBD cord-001446-mpuovmeb 117 22 analyzed analyze VBN cord-001446-mpuovmeb 117 23 . . . cord-001446-mpuovmeb 118 1 Given give VBN cord-001446-mpuovmeb 118 2 the the DT cord-001446-mpuovmeb 118 3 confounders confounder NNS cord-001446-mpuovmeb 118 4 mentioned mention VBN cord-001446-mpuovmeb 118 5 above above RB cord-001446-mpuovmeb 118 6 , , , cord-001446-mpuovmeb 118 7 it -PRON- PRP cord-001446-mpuovmeb 118 8 is be VBZ cord-001446-mpuovmeb 118 9 possible possible JJ cord-001446-mpuovmeb 118 10 that that IN cord-001446-mpuovmeb 118 11 the the DT cord-001446-mpuovmeb 118 12 antibody antibody NN cord-001446-mpuovmeb 118 13 from from IN cord-001446-mpuovmeb 118 14 the the DT cord-001446-mpuovmeb 118 15 kit kit NN cord-001446-mpuovmeb 118 16 recognizes recognize VBZ cord-001446-mpuovmeb 118 17 an an DT cord-001446-mpuovmeb 118 18 epitope epitope NN cord-001446-mpuovmeb 118 19 that that WDT cord-001446-mpuovmeb 118 20 is be VBZ cord-001446-mpuovmeb 118 21 not not RB cord-001446-mpuovmeb 118 22 post post JJ cord-001446-mpuovmeb 118 23 - - JJ cord-001446-mpuovmeb 118 24 translationally translationally RB cord-001446-mpuovmeb 118 25 modified modify VBN cord-001446-mpuovmeb 118 26 or or CC cord-001446-mpuovmeb 118 27 altered alter VBN cord-001446-mpuovmeb 118 28 in in IN cord-001446-mpuovmeb 118 29 human human JJ cord-001446-mpuovmeb 118 30 serum serum NN cord-001446-mpuovmeb 118 31 / / SYM cord-001446-mpuovmeb 118 32 plasma plasma NN cord-001446-mpuovmeb 118 33 SP sp NN cord-001446-mpuovmeb 118 34 - - HYPH cord-001446-mpuovmeb 118 35 D D NNP cord-001446-mpuovmeb 118 36 , , , cord-001446-mpuovmeb 118 37 while while IN cord-001446-mpuovmeb 118 38 several several JJ cord-001446-mpuovmeb 118 39 of of IN cord-001446-mpuovmeb 118 40 the the DT cord-001446-mpuovmeb 118 41 epitopes epitope NNS cord-001446-mpuovmeb 118 42 recognized recognize VBN cord-001446-mpuovmeb 118 43 by by IN cord-001446-mpuovmeb 118 44 the the DT cord-001446-mpuovmeb 118 45 polyclonal polyclonal JJ cord-001446-mpuovmeb 118 46 antibody antibody NN cord-001446-mpuovmeb 118 47 are be VBP cord-001446-mpuovmeb 118 48 modified modify VBN cord-001446-mpuovmeb 118 49 in in IN cord-001446-mpuovmeb 118 50 human human JJ cord-001446-mpuovmeb 118 51 serum serum NN cord-001446-mpuovmeb 118 52 / / SYM cord-001446-mpuovmeb 118 53 plasma plasma NN cord-001446-mpuovmeb 118 54 SP sp NN cord-001446-mpuovmeb 118 55 - - HYPH cord-001446-mpuovmeb 118 56 D D NNP cord-001446-mpuovmeb 118 57 , , , cord-001446-mpuovmeb 118 58 but but CC cord-001446-mpuovmeb 118 59 were be VBD cord-001446-mpuovmeb 118 60 unmodified unmodified JJ cord-001446-mpuovmeb 118 61 in in IN cord-001446-mpuovmeb 118 62 the the DT cord-001446-mpuovmeb 118 63 recombinantly recombinantly RB cord-001446-mpuovmeb 118 64 expressed express VBN cord-001446-mpuovmeb 118 65 SP SP NNP cord-001446-mpuovmeb 118 66 - - HYPH cord-001446-mpuovmeb 118 67 D D NNP cord-001446-mpuovmeb 118 68 ( ( -LRB- cord-001446-mpuovmeb 118 69 which which WDT cord-001446-mpuovmeb 118 70 was be VBD cord-001446-mpuovmeb 118 71 used use VBN cord-001446-mpuovmeb 118 72 as as IN cord-001446-mpuovmeb 118 73 the the DT cord-001446-mpuovmeb 118 74 immunogen immunogen NN cord-001446-mpuovmeb 118 75 ) ) -RRB- cord-001446-mpuovmeb 118 76 . . . cord-001446-mpuovmeb 119 1 This this DT cord-001446-mpuovmeb 119 2 would would MD cord-001446-mpuovmeb 119 3 result result VB cord-001446-mpuovmeb 119 4 in in IN cord-001446-mpuovmeb 119 5 the the DT cord-001446-mpuovmeb 119 6 observed observed JJ cord-001446-mpuovmeb 119 7 relative relative JJ cord-001446-mpuovmeb 119 8 decrease decrease NN cord-001446-mpuovmeb 119 9 in in IN cord-001446-mpuovmeb 119 10 binding binding NN cord-001446-mpuovmeb 119 11 of of IN cord-001446-mpuovmeb 119 12 the the DT cord-001446-mpuovmeb 119 13 native native JJ cord-001446-mpuovmeb 119 14 SP SP NNP cord-001446-mpuovmeb 119 15 - - HYPH cord-001446-mpuovmeb 119 16 D D NNP cord-001446-mpuovmeb 119 17 from from IN cord-001446-mpuovmeb 119 18 the the DT cord-001446-mpuovmeb 119 19 blood blood NN cord-001446-mpuovmeb 119 20 compared compare VBN cord-001446-mpuovmeb 119 21 to to IN cord-001446-mpuovmeb 119 22 the the DT cord-001446-mpuovmeb 119 23 recombinant recombinant JJ cord-001446-mpuovmeb 119 24 SP SP NNP cord-001446-mpuovmeb 119 25 - - HYPH cord-001446-mpuovmeb 119 26 D. D. NNP cord-001446-mpuovmeb 119 27 Accuracy Accuracy NNP cord-001446-mpuovmeb 119 28 of of IN cord-001446-mpuovmeb 119 29 SP SP NNP cord-001446-mpuovmeb 119 30 - - HYPH cord-001446-mpuovmeb 119 31 D d JJ cord-001446-mpuovmeb 119 32 measurements measurement NNS cord-001446-mpuovmeb 119 33 is be VBZ cord-001446-mpuovmeb 119 34 critically critically RB cord-001446-mpuovmeb 119 35 important important JJ cord-001446-mpuovmeb 119 36 to to IN cord-001446-mpuovmeb 119 37 the the DT cord-001446-mpuovmeb 119 38 validation validation NN cord-001446-mpuovmeb 119 39 of of IN cord-001446-mpuovmeb 119 40 this this DT cord-001446-mpuovmeb 119 41 protein protein NN cord-001446-mpuovmeb 119 42 as as IN cord-001446-mpuovmeb 119 43 a a DT cord-001446-mpuovmeb 119 44 biomarker biomarker NN cord-001446-mpuovmeb 119 45 in in IN cord-001446-mpuovmeb 119 46 pulmonary pulmonary JJ cord-001446-mpuovmeb 119 47 disease disease NN cord-001446-mpuovmeb 119 48 . . . cord-001446-mpuovmeb 120 1 Standardization standardization NN cord-001446-mpuovmeb 120 2 of of IN cord-001446-mpuovmeb 120 3 sample sample NN cord-001446-mpuovmeb 120 4 processing processing NN cord-001446-mpuovmeb 120 5 and and CC cord-001446-mpuovmeb 120 6 storage storage NN cord-001446-mpuovmeb 120 7 , , , cord-001446-mpuovmeb 120 8 including include VBG cord-001446-mpuovmeb 120 9 the the DT cord-001446-mpuovmeb 120 10 avoidance avoidance NN cord-001446-mpuovmeb 120 11 of of IN cord-001446-mpuovmeb 120 12 EDTA EDTA NNP cord-001446-mpuovmeb 120 13 as as IN cord-001446-mpuovmeb 120 14 an an DT cord-001446-mpuovmeb 120 15 anticoagulant anticoagulant NN cord-001446-mpuovmeb 120 16 , , , cord-001446-mpuovmeb 120 17 is be VBZ cord-001446-mpuovmeb 120 18 necessary necessary JJ cord-001446-mpuovmeb 120 19 to to TO cord-001446-mpuovmeb 120 20 ensure ensure VB cord-001446-mpuovmeb 120 21 consistent consistent JJ cord-001446-mpuovmeb 120 22 results result NNS cord-001446-mpuovmeb 120 23 . . . cord-001446-mpuovmeb 121 1 Although although IN cord-001446-mpuovmeb 121 2 absolute absolute JJ cord-001446-mpuovmeb 121 3 values value NNS cord-001446-mpuovmeb 121 4 may may MD cord-001446-mpuovmeb 121 5 vary vary VB cord-001446-mpuovmeb 121 6 greatly greatly RB cord-001446-mpuovmeb 121 7 due due JJ cord-001446-mpuovmeb 121 8 to to IN cord-001446-mpuovmeb 121 9 the the DT cord-001446-mpuovmeb 121 10 ELISA ELISA NNP cord-001446-mpuovmeb 121 11 configuration configuration NN cord-001446-mpuovmeb 121 12 employed employ VBN cord-001446-mpuovmeb 121 13 , , , cord-001446-mpuovmeb 121 14 relative relative JJ cord-001446-mpuovmeb 121 15 differences difference NNS cord-001446-mpuovmeb 121 16 in in IN cord-001446-mpuovmeb 121 17 SP SP NNP cord-001446-mpuovmeb 121 18 - - HYPH cord-001446-mpuovmeb 121 19 D d JJ cord-001446-mpuovmeb 121 20 concentrations concentration NNS cord-001446-mpuovmeb 121 21 amongst amongst IN cord-001446-mpuovmeb 121 22 various various JJ cord-001446-mpuovmeb 121 23 disease disease NN cord-001446-mpuovmeb 121 24 groups group NNS cord-001446-mpuovmeb 121 25 should should MD cord-001446-mpuovmeb 121 26 be be VB cord-001446-mpuovmeb 121 27 consistent consistent JJ cord-001446-mpuovmeb 121 28 throughout throughout IN cord-001446-mpuovmeb 121 29 the the DT cord-001446-mpuovmeb 121 30 published publish VBN cord-001446-mpuovmeb 121 31 literature literature NN cord-001446-mpuovmeb 121 32 . . . cord-001446-mpuovmeb 122 1 We -PRON- PRP cord-001446-mpuovmeb 122 2 are be VBP cord-001446-mpuovmeb 122 3 currently currently RB cord-001446-mpuovmeb 122 4 exploring explore VBG cord-001446-mpuovmeb 122 5 alternative alternative JJ cord-001446-mpuovmeb 122 6 methods method NNS cord-001446-mpuovmeb 122 7 to to TO cord-001446-mpuovmeb 122 8 quantify quantify VB cord-001446-mpuovmeb 122 9 SP SP NNP cord-001446-mpuovmeb 122 10 - - HYPH cord-001446-mpuovmeb 122 11 D d JJ cord-001446-mpuovmeb 122 12 levels level NNS cord-001446-mpuovmeb 122 13 in in IN cord-001446-mpuovmeb 122 14 the the DT cord-001446-mpuovmeb 122 15 blood blood NN cord-001446-mpuovmeb 122 16 , , , cord-001446-mpuovmeb 122 17 as as IN cord-001446-mpuovmeb 122 18 we -PRON- PRP cord-001446-mpuovmeb 122 19 believe believe VBP cord-001446-mpuovmeb 122 20 this this DT cord-001446-mpuovmeb 122 21 is be VBZ cord-001446-mpuovmeb 122 22 necessary necessary JJ cord-001446-mpuovmeb 122 23 in in IN cord-001446-mpuovmeb 122 24 order order NN cord-001446-mpuovmeb 122 25 to to TO cord-001446-mpuovmeb 122 26 establish establish VB cord-001446-mpuovmeb 122 27 the the DT cord-001446-mpuovmeb 122 28 absolute absolute JJ cord-001446-mpuovmeb 122 29 concentration concentration NN cord-001446-mpuovmeb 122 30 . . . cord-001446-mpuovmeb 123 1 Surfactant surfactant NN cord-001446-mpuovmeb 123 2 proteins protein NNS cord-001446-mpuovmeb 123 3 SP SP NNP cord-001446-mpuovmeb 123 4 - - HYPH cord-001446-mpuovmeb 123 5 A A NNP cord-001446-mpuovmeb 123 6 and and CC cord-001446-mpuovmeb 123 7 SP SP NNP cord-001446-mpuovmeb 123 8 - - HYPH cord-001446-mpuovmeb 123 9 D d JJ cord-001446-mpuovmeb 123 10 : : : cord-001446-mpuovmeb 123 11 structure structure NN cord-001446-mpuovmeb 123 12 , , , cord-001446-mpuovmeb 123 13 function function NN cord-001446-mpuovmeb 123 14 and and CC cord-001446-mpuovmeb 123 15 receptors receptor NNS cord-001446-mpuovmeb 123 16 Surfactant Surfactant NNP cord-001446-mpuovmeb 123 17 protein protein NN cord-001446-mpuovmeb 123 18 D d NN cord-001446-mpuovmeb 123 19 ( ( -LRB- cord-001446-mpuovmeb 123 20 SP SP NNP cord-001446-mpuovmeb 123 21 - - HYPH cord-001446-mpuovmeb 123 22 D D NNP cord-001446-mpuovmeb 123 23 ) ) -RRB- cord-001446-mpuovmeb 123 24 and and CC cord-001446-mpuovmeb 123 25 systemic systemic JJ cord-001446-mpuovmeb 123 26 scleroderma scleroderma NNS cord-001446-mpuovmeb 123 27 ( ( -LRB- cord-001446-mpuovmeb 123 28 SSc SSc NNS cord-001446-mpuovmeb 123 29 ) ) -RRB- cord-001446-mpuovmeb 124 1 Surfactant surfactant NN cord-001446-mpuovmeb 124 2 protein protein NN cord-001446-mpuovmeb 124 3 D d NN cord-001446-mpuovmeb 124 4 in in IN cord-001446-mpuovmeb 124 5 atopic atopic JJ cord-001446-mpuovmeb 124 6 dermatitis dermatitis NN cord-001446-mpuovmeb 124 7 and and CC cord-001446-mpuovmeb 124 8 psoriasis psoriasis NN cord-001446-mpuovmeb 124 9 Plasma plasma NN cord-001446-mpuovmeb 124 10 surfactant surfactant NN cord-001446-mpuovmeb 124 11 protein protein NN cord-001446-mpuovmeb 124 12 levels level NNS cord-001446-mpuovmeb 124 13 and and CC cord-001446-mpuovmeb 124 14 clinical clinical JJ cord-001446-mpuovmeb 124 15 outcomes outcome NNS cord-001446-mpuovmeb 124 16 in in IN cord-001446-mpuovmeb 124 17 patients patient NNS cord-001446-mpuovmeb 124 18 with with IN cord-001446-mpuovmeb 124 19 acute acute JJ cord-001446-mpuovmeb 124 20 lung lung NN cord-001446-mpuovmeb 124 21 injury injury NN cord-001446-mpuovmeb 124 22 Effects effect NNS cord-001446-mpuovmeb 124 23 of of IN cord-001446-mpuovmeb 124 24 leukoreduced leukoreduced JJ cord-001446-mpuovmeb 124 25 blood blood NN cord-001446-mpuovmeb 124 26 on on IN cord-001446-mpuovmeb 124 27 acute acute JJ cord-001446-mpuovmeb 124 28 lung lung NN cord-001446-mpuovmeb 124 29 injury injury NN cord-001446-mpuovmeb 124 30 after after IN cord-001446-mpuovmeb 124 31 trauma trauma NN cord-001446-mpuovmeb 124 32 : : : cord-001446-mpuovmeb 125 1 a a DT cord-001446-mpuovmeb 125 2 randomized randomized JJ cord-001446-mpuovmeb 125 3 controlled control VBN cord-001446-mpuovmeb 125 4 trial trial NN cord-001446-mpuovmeb 125 5 Surfactant Surfactant NNP cord-001446-mpuovmeb 125 6 phospholipids phospholipid NNS cord-001446-mpuovmeb 125 7 , , , cord-001446-mpuovmeb 125 8 surfactant surfactant NN cord-001446-mpuovmeb 125 9 proteins protein NNS cord-001446-mpuovmeb 125 10 , , , cord-001446-mpuovmeb 125 11 and and CC cord-001446-mpuovmeb 125 12 inflammatory inflammatory JJ cord-001446-mpuovmeb 125 13 markers marker NNS cord-001446-mpuovmeb 125 14 during during IN cord-001446-mpuovmeb 125 15 acute acute JJ cord-001446-mpuovmeb 125 16 lung lung NN cord-001446-mpuovmeb 125 17 injury injury NN cord-001446-mpuovmeb 125 18 in in IN cord-001446-mpuovmeb 125 19 children child NNS cord-001446-mpuovmeb 125 20 Prognostic prognostic JJ cord-001446-mpuovmeb 125 21 and and CC cord-001446-mpuovmeb 125 22 pathogenetic pathogenetic JJ cord-001446-mpuovmeb 125 23 value value NN cord-001446-mpuovmeb 125 24 of of IN cord-001446-mpuovmeb 125 25 combining combine VBG cord-001446-mpuovmeb 125 26 clinical clinical JJ cord-001446-mpuovmeb 125 27 and and CC cord-001446-mpuovmeb 125 28 biochemical biochemical JJ cord-001446-mpuovmeb 125 29 indices index NNS cord-001446-mpuovmeb 125 30 in in IN cord-001446-mpuovmeb 125 31 patients patient NNS cord-001446-mpuovmeb 125 32 with with IN cord-001446-mpuovmeb 125 33 acute acute JJ cord-001446-mpuovmeb 125 34 lung lung NN cord-001446-mpuovmeb 125 35 injury injury NN cord-001446-mpuovmeb 125 36 Plasma Plasma NNP cord-001446-mpuovmeb 125 37 CC16 CC16 NNP cord-001446-mpuovmeb 125 38 levels level NNS cord-001446-mpuovmeb 125 39 are be VBP cord-001446-mpuovmeb 125 40 associated associate VBN cord-001446-mpuovmeb 125 41 with with IN cord-001446-mpuovmeb 125 42 development development NN cord-001446-mpuovmeb 125 43 of of IN cord-001446-mpuovmeb 125 44 ALI ALI NNP cord-001446-mpuovmeb 125 45 / / SYM cord-001446-mpuovmeb 125 46 ARDS ARDS NNP cord-001446-mpuovmeb 125 47 in in IN cord-001446-mpuovmeb 125 48 patients patient NNS cord-001446-mpuovmeb 125 49 with with IN cord-001446-mpuovmeb 125 50 ventilator ventilator NN cord-001446-mpuovmeb 125 51 - - HYPH cord-001446-mpuovmeb 125 52 associated associate VBN cord-001446-mpuovmeb 125 53 pneumonia pneumonia NN cord-001446-mpuovmeb 125 54 : : : cord-001446-mpuovmeb 126 1 a a DT cord-001446-mpuovmeb 126 2 retrospective retrospective JJ cord-001446-mpuovmeb 126 3 observational observational JJ cord-001446-mpuovmeb 126 4 study study NN cord-001446-mpuovmeb 126 5 Plasma Plasma NNP cord-001446-mpuovmeb 126 6 levels level NNS cord-001446-mpuovmeb 126 7 of of IN cord-001446-mpuovmeb 126 8 surfactant surfactant NN cord-001446-mpuovmeb 126 9 protein protein NN cord-001446-mpuovmeb 126 10 D D NNP cord-001446-mpuovmeb 126 11 and and CC cord-001446-mpuovmeb 126 12 KL-6 KL-6 NNP cord-001446-mpuovmeb 126 13 for for IN cord-001446-mpuovmeb 126 14 evaluation evaluation NN cord-001446-mpuovmeb 126 15 of of IN cord-001446-mpuovmeb 126 16 lung lung NN cord-001446-mpuovmeb 126 17 injury injury NN cord-001446-mpuovmeb 126 18 in in IN cord-001446-mpuovmeb 126 19 critically critically RB cord-001446-mpuovmeb 126 20 ill ill JJ cord-001446-mpuovmeb 126 21 mechanically mechanically RB cord-001446-mpuovmeb 126 22 ventilated ventilate VBN cord-001446-mpuovmeb 126 23 patients patient NNS cord-001446-mpuovmeb 126 24 Plasma plasma NN cord-001446-mpuovmeb 126 25 biomarker biomarker NN cord-001446-mpuovmeb 126 26 profiles profile NNS cord-001446-mpuovmeb 126 27 in in IN cord-001446-mpuovmeb 126 28 acute acute JJ cord-001446-mpuovmeb 126 29 exacerbation exacerbation NN cord-001446-mpuovmeb 126 30 of of IN cord-001446-mpuovmeb 126 31 idiopathic idiopathic JJ cord-001446-mpuovmeb 126 32 pulmonary pulmonary JJ cord-001446-mpuovmeb 126 33 fibrosis fibrosis NN cord-001446-mpuovmeb 126 34 Biomarkers Biomarkers NNPS cord-001446-mpuovmeb 126 35 of of IN cord-001446-mpuovmeb 126 36 lung lung NN cord-001446-mpuovmeb 126 37 epithelial epithelial JJ cord-001446-mpuovmeb 126 38 injury injury NN cord-001446-mpuovmeb 126 39 and and CC cord-001446-mpuovmeb 126 40 inflammation inflammation NN cord-001446-mpuovmeb 126 41 distinguish distinguish VBP cord-001446-mpuovmeb 126 42 severe severe JJ cord-001446-mpuovmeb 126 43 sepsis sepsis NN cord-001446-mpuovmeb 126 44 patients patient NNS cord-001446-mpuovmeb 126 45 with with IN cord-001446-mpuovmeb 126 46 acute acute JJ cord-001446-mpuovmeb 126 47 respiratory respiratory JJ cord-001446-mpuovmeb 126 48 distress distress NN cord-001446-mpuovmeb 126 49 syndrome syndrome NN cord-001446-mpuovmeb 126 50 Serum serum NN cord-001446-mpuovmeb 126 51 surfactant surfactant NN cord-001446-mpuovmeb 126 52 proteins protein NNS cord-001446-mpuovmeb 126 53 - - : cord-001446-mpuovmeb 126 54 A a NN cord-001446-mpuovmeb 126 55 and and CC cord-001446-mpuovmeb 126 56 -D -d NN cord-001446-mpuovmeb 126 57 as as IN cord-001446-mpuovmeb 126 58 biomarkers biomarker NNS cord-001446-mpuovmeb 126 59 in in IN cord-001446-mpuovmeb 126 60 idiopathic idiopathic JJ cord-001446-mpuovmeb 126 61 pulmonary pulmonary JJ cord-001446-mpuovmeb 126 62 fibrosis fibrosis NN cord-001446-mpuovmeb 127 1 Serial serial JJ cord-001446-mpuovmeb 127 2 changes change NNS cord-001446-mpuovmeb 127 3 in in IN cord-001446-mpuovmeb 127 4 surfactant surfactant NN cord-001446-mpuovmeb 127 5 - - HYPH cord-001446-mpuovmeb 127 6 associated associate VBN cord-001446-mpuovmeb 127 7 proteins protein NNS cord-001446-mpuovmeb 127 8 in in IN cord-001446-mpuovmeb 127 9 lung lung NN cord-001446-mpuovmeb 127 10 and and CC cord-001446-mpuovmeb 127 11 serum serum NN cord-001446-mpuovmeb 127 12 before before IN cord-001446-mpuovmeb 127 13 and and CC cord-001446-mpuovmeb 127 14 after after IN cord-001446-mpuovmeb 127 15 onset onset NN cord-001446-mpuovmeb 127 16 of of IN cord-001446-mpuovmeb 127 17 ARDS ARDS NNP cord-001446-mpuovmeb 127 18 Increased increase VBN cord-001446-mpuovmeb 127 19 plasma plasma NN cord-001446-mpuovmeb 127 20 concentration concentration NN cord-001446-mpuovmeb 127 21 of of IN cord-001446-mpuovmeb 127 22 surfactant surfactant NN cord-001446-mpuovmeb 127 23 protein protein NN cord-001446-mpuovmeb 127 24 D d NN cord-001446-mpuovmeb 127 25 in in IN cord-001446-mpuovmeb 127 26 chronic chronic JJ cord-001446-mpuovmeb 127 27 periodontitis periodontitis NN cord-001446-mpuovmeb 128 1 independent independent JJ cord-001446-mpuovmeb 128 2 of of IN cord-001446-mpuovmeb 128 3 SFTPD SFTPD NNP cord-001446-mpuovmeb 128 4 genotype genotype NN cord-001446-mpuovmeb 128 5 : : : cord-001446-mpuovmeb 128 6 potential potential JJ cord-001446-mpuovmeb 128 7 role role NN cord-001446-mpuovmeb 128 8 as as IN cord-001446-mpuovmeb 128 9 a a DT cord-001446-mpuovmeb 128 10 biomarker biomarker NN cord-001446-mpuovmeb 128 11 Effect effect NN cord-001446-mpuovmeb 128 12 of of IN cord-001446-mpuovmeb 128 13 single single JJ cord-001446-mpuovmeb 128 14 vs vs IN cord-001446-mpuovmeb 128 15 bilateral bilateral JJ cord-001446-mpuovmeb 128 16 lung lung NN cord-001446-mpuovmeb 128 17 transplantation transplantation NN cord-001446-mpuovmeb 128 18 on on IN cord-001446-mpuovmeb 128 19 plasma plasma NN cord-001446-mpuovmeb 128 20 surfactant surfactant NN cord-001446-mpuovmeb 128 21 protein protein NN cord-001446-mpuovmeb 128 22 D d NN cord-001446-mpuovmeb 128 23 levels level NNS cord-001446-mpuovmeb 128 24 in in IN cord-001446-mpuovmeb 128 25 idiopathic idiopathic JJ cord-001446-mpuovmeb 128 26 pulmonary pulmonary JJ cord-001446-mpuovmeb 128 27 fibrosis fibrosis NN cord-001446-mpuovmeb 128 28 Pulmonary pulmonary JJ cord-001446-mpuovmeb 128 29 surfactant surfactant NN cord-001446-mpuovmeb 128 30 protein protein NN cord-001446-mpuovmeb 128 31 D D NNP cord-001446-mpuovmeb 128 32 in in IN cord-001446-mpuovmeb 128 33 sera sera NNP cord-001446-mpuovmeb 128 34 and and CC cord-001446-mpuovmeb 128 35 bronchoalveolar bronchoalveolar NNP cord-001446-mpuovmeb 128 36 lavage lavage NN cord-001446-mpuovmeb 128 37 fluids fluid NNS cord-001446-mpuovmeb 129 1 Enzymelinked enzymelinked JJ cord-001446-mpuovmeb 129 2 immunosorbent immunosorbent JJ cord-001446-mpuovmeb 129 3 assay assay NN cord-001446-mpuovmeb 129 4 using use VBG cord-001446-mpuovmeb 129 5 F(ab')2 F(ab')2 NNP cord-001446-mpuovmeb 129 6 fragment fragment NN cord-001446-mpuovmeb 129 7 for for IN cord-001446-mpuovmeb 129 8 the the DT cord-001446-mpuovmeb 129 9 detection detection NN cord-001446-mpuovmeb 129 10 of of IN cord-001446-mpuovmeb 129 11 human human JJ cord-001446-mpuovmeb 129 12 pulmonary pulmonary JJ cord-001446-mpuovmeb 129 13 surfactant surfactant NN cord-001446-mpuovmeb 129 14 protein protein NN cord-001446-mpuovmeb 129 15 D D NNP cord-001446-mpuovmeb 129 16 in in IN cord-001446-mpuovmeb 129 17 sera sera NNP cord-001446-mpuovmeb 129 18 Comparative Comparative NNP cord-001446-mpuovmeb 129 19 study study NN cord-001446-mpuovmeb 129 20 of of IN cord-001446-mpuovmeb 129 21 KL-6 KL-6 NNP cord-001446-mpuovmeb 129 22 , , , cord-001446-mpuovmeb 129 23 surfactant surfactant NN cord-001446-mpuovmeb 129 24 protein protein NN cord-001446-mpuovmeb 129 25 - - HYPH cord-001446-mpuovmeb 129 26 A a NN cord-001446-mpuovmeb 129 27 , , , cord-001446-mpuovmeb 129 28 surfactant surfactant NN cord-001446-mpuovmeb 129 29 protein protein NN cord-001446-mpuovmeb 129 30 - - HYPH cord-001446-mpuovmeb 129 31 D D NNP cord-001446-mpuovmeb 129 32 , , , cord-001446-mpuovmeb 129 33 and and CC cord-001446-mpuovmeb 129 34 monocyte monocyte NNP cord-001446-mpuovmeb 129 35 chemoattractant chemoattractant NNP cord-001446-mpuovmeb 129 36 protein-1 protein-1 NNP cord-001446-mpuovmeb 129 37 as as IN cord-001446-mpuovmeb 129 38 serum serum NN cord-001446-mpuovmeb 129 39 markers marker NNS cord-001446-mpuovmeb 129 40 for for IN cord-001446-mpuovmeb 129 41 interstitial interstitial JJ cord-001446-mpuovmeb 129 42 lung lung NN cord-001446-mpuovmeb 129 43 diseases disease NNS cord-001446-mpuovmeb 129 44 Increased increase VBD cord-001446-mpuovmeb 129 45 circulating circulate VBG cord-001446-mpuovmeb 129 46 levels level NNS cord-001446-mpuovmeb 129 47 of of IN cord-001446-mpuovmeb 129 48 soluble soluble JJ cord-001446-mpuovmeb 129 49 Fas Fas NNP cord-001446-mpuovmeb 129 50 ligand ligand NN cord-001446-mpuovmeb 129 51 are be VBP cord-001446-mpuovmeb 129 52 correlated correlate VBN cord-001446-mpuovmeb 129 53 with with IN cord-001446-mpuovmeb 129 54 disease disease NN cord-001446-mpuovmeb 129 55 activity activity NN cord-001446-mpuovmeb 129 56 in in IN cord-001446-mpuovmeb 129 57 patients patient NNS cord-001446-mpuovmeb 129 58 with with IN cord-001446-mpuovmeb 129 59 fibrosing fibrose VBG cord-001446-mpuovmeb 129 60 lung lung NN cord-001446-mpuovmeb 129 61 diseases disease NNS cord-001446-mpuovmeb 129 62 Monitoring monitor VBG cord-001446-mpuovmeb 129 63 markers marker NNS cord-001446-mpuovmeb 129 64 of of IN cord-001446-mpuovmeb 129 65 disease disease NN cord-001446-mpuovmeb 129 66 activity activity NN cord-001446-mpuovmeb 129 67 for for IN cord-001446-mpuovmeb 129 68 interstitial interstitial JJ cord-001446-mpuovmeb 129 69 lung lung NN cord-001446-mpuovmeb 129 70 diseases disease NNS cord-001446-mpuovmeb 129 71 with with IN cord-001446-mpuovmeb 129 72 serum serum NN cord-001446-mpuovmeb 129 73 surfactant surfactant NN cord-001446-mpuovmeb 129 74 proteins protein VBZ cord-001446-mpuovmeb 129 75 A A NNP cord-001446-mpuovmeb 129 76 and and CC cord-001446-mpuovmeb 129 77 D D NNP cord-001446-mpuovmeb 129 78 Clinical clinical JJ cord-001446-mpuovmeb 129 79 importance importance NN cord-001446-mpuovmeb 129 80 of of IN cord-001446-mpuovmeb 129 81 bronchoalveolar bronchoalveolar NNP cord-001446-mpuovmeb 129 82 lavage lavage NN cord-001446-mpuovmeb 129 83 fluid fluid NN cord-001446-mpuovmeb 129 84 and and CC cord-001446-mpuovmeb 129 85 blood blood NN cord-001446-mpuovmeb 129 86 cytokines cytokine NNS cord-001446-mpuovmeb 129 87 , , , cord-001446-mpuovmeb 129 88 surfactant surfactant NN cord-001446-mpuovmeb 129 89 protein protein NN cord-001446-mpuovmeb 129 90 D D NNP cord-001446-mpuovmeb 129 91 , , , cord-001446-mpuovmeb 129 92 and and CC cord-001446-mpuovmeb 129 93 Kerbs kerb NNS cord-001446-mpuovmeb 129 94 von von NNP cord-001446-mpuovmeb 129 95 Lungren Lungren NNP cord-001446-mpuovmeb 129 96 6 6 CD cord-001446-mpuovmeb 129 97 antigen antigen NN cord-001446-mpuovmeb 129 98 in in IN cord-001446-mpuovmeb 129 99 idiopathic idiopathic JJ cord-001446-mpuovmeb 129 100 pulmonary pulmonary JJ cord-001446-mpuovmeb 129 101 alveolar alveolar NN cord-001446-mpuovmeb 129 102 proteinosis proteinosis NN cord-001446-mpuovmeb 129 103 Significance significance NN cord-001446-mpuovmeb 129 104 of of IN cord-001446-mpuovmeb 129 105 serum serum NN cord-001446-mpuovmeb 129 106 vascular vascular JJ cord-001446-mpuovmeb 129 107 endothelial endothelial JJ cord-001446-mpuovmeb 129 108 growth growth NN cord-001446-mpuovmeb 129 109 factor factor NN cord-001446-mpuovmeb 129 110 level level NN cord-001446-mpuovmeb 129 111 in in IN cord-001446-mpuovmeb 129 112 patients patient NNS cord-001446-mpuovmeb 129 113 with with IN cord-001446-mpuovmeb 129 114 idiopathic idiopathic JJ cord-001446-mpuovmeb 129 115 pulmonary pulmonary JJ cord-001446-mpuovmeb 129 116 fibrosis fibrosis NN cord-001446-mpuovmeb 129 117 Pneumocyte Pneumocyte NNP cord-001446-mpuovmeb 129 118 biomarkers biomarker NNS cord-001446-mpuovmeb 129 119 KL-6 kl-6 JJ cord-001446-mpuovmeb 129 120 and and CC cord-001446-mpuovmeb 129 121 surfactant surfactant NN cord-001446-mpuovmeb 129 122 protein protein NN cord-001446-mpuovmeb 129 123 D D NNP cord-001446-mpuovmeb 130 1 reflect reflect VB cord-001446-mpuovmeb 130 2 the the DT cord-001446-mpuovmeb 130 3 distinct distinct JJ cord-001446-mpuovmeb 130 4 findings finding NNS cord-001446-mpuovmeb 130 5 of of IN cord-001446-mpuovmeb 130 6 high high JJ cord-001446-mpuovmeb 130 7 - - HYPH cord-001446-mpuovmeb 130 8 resolution resolution NN cord-001446-mpuovmeb 130 9 computed compute VBN cord-001446-mpuovmeb 130 10 tomography tomography NN cord-001446-mpuovmeb 130 11 in in IN cord-001446-mpuovmeb 130 12 nonspecific nonspecific JJ cord-001446-mpuovmeb 130 13 interstitial interstitial JJ cord-001446-mpuovmeb 130 14 pneumonia pneumonia NN cord-001446-mpuovmeb 130 15 Integrating integrate VBG cord-001446-mpuovmeb 130 16 lung lung NN cord-001446-mpuovmeb 130 17 and and CC cord-001446-mpuovmeb 130 18 plasma plasma NN cord-001446-mpuovmeb 130 19 expression expression NN cord-001446-mpuovmeb 130 20 of of IN cord-001446-mpuovmeb 130 21 pneumo pneumo NN cord-001446-mpuovmeb 130 22 - - HYPH cord-001446-mpuovmeb 130 23 proteins protein NNS cord-001446-mpuovmeb 130 24 in in IN cord-001446-mpuovmeb 130 25 developing develop VBG cord-001446-mpuovmeb 130 26 biomarkers biomarker NNS cord-001446-mpuovmeb 130 27 in in IN cord-001446-mpuovmeb 130 28 COPD COPD NNP cord-001446-mpuovmeb 130 29 : : : cord-001446-mpuovmeb 130 30 a a DT cord-001446-mpuovmeb 130 31 case case NN cord-001446-mpuovmeb 130 32 study study NN cord-001446-mpuovmeb 130 33 of of IN cord-001446-mpuovmeb 130 34 surfactant surfactant NN cord-001446-mpuovmeb 130 35 protein protein NN cord-001446-mpuovmeb 130 36 D D NNP cord-001446-mpuovmeb 130 37 Ageing ageing NN cord-001446-mpuovmeb 130 38 and and CC cord-001446-mpuovmeb 130 39 smoking smoking NN cord-001446-mpuovmeb 130 40 contribute contribute VBP cord-001446-mpuovmeb 130 41 to to IN cord-001446-mpuovmeb 130 42 plasma plasma NN cord-001446-mpuovmeb 130 43 surfactant surfactant NN cord-001446-mpuovmeb 130 44 proteins protein NNS cord-001446-mpuovmeb 130 45 and and CC cord-001446-mpuovmeb 130 46 protease protease NN cord-001446-mpuovmeb 130 47 imbalance imbalance NN cord-001446-mpuovmeb 130 48 with with IN cord-001446-mpuovmeb 130 49 correlations correlation NNS cord-001446-mpuovmeb 130 50 to to IN cord-001446-mpuovmeb 130 51 airway airway VB cord-001446-mpuovmeb 130 52 obstruction obstruction NN cord-001446-mpuovmeb 130 53 Inflammatory inflammatory JJ cord-001446-mpuovmeb 130 54 biomarkers biomarker NNS cord-001446-mpuovmeb 130 55 improve improve VBP cord-001446-mpuovmeb 130 56 clinical clinical JJ cord-001446-mpuovmeb 130 57 prediction prediction NN cord-001446-mpuovmeb 130 58 of of IN cord-001446-mpuovmeb 130 59 mortality mortality NN cord-001446-mpuovmeb 130 60 in in IN cord-001446-mpuovmeb 130 61 chronic chronic JJ cord-001446-mpuovmeb 130 62 obstructive obstructive JJ cord-001446-mpuovmeb 130 63 pulmonary pulmonary JJ cord-001446-mpuovmeb 130 64 disease disease NN cord-001446-mpuovmeb 131 1 Budesonide Budesonide NNP cord-001446-mpuovmeb 131 2 / / SYM cord-001446-mpuovmeb 131 3 formoterol formoterol NNP cord-001446-mpuovmeb 131 4 enhances enhance VBZ cord-001446-mpuovmeb 131 5 the the DT cord-001446-mpuovmeb 131 6 expression expression NN cord-001446-mpuovmeb 131 7 of of IN cord-001446-mpuovmeb 131 8 pro pro NNP cord-001446-mpuovmeb 131 9 Surfactant Surfactant NNP cord-001446-mpuovmeb 131 10 Protein Protein NNP cord-001446-mpuovmeb 131 11 - - HYPH cord-001446-mpuovmeb 131 12 B B NNP cord-001446-mpuovmeb 131 13 in in IN cord-001446-mpuovmeb 131 14 lungs lung NNS cord-001446-mpuovmeb 131 15 of of IN cord-001446-mpuovmeb 131 16 COPD COPD NNP cord-001446-mpuovmeb 131 17 patients patient NNS cord-001446-mpuovmeb 131 18 Exhaled exhale VBD cord-001446-mpuovmeb 131 19 metallic metallic JJ cord-001446-mpuovmeb 131 20 elements element NNS cord-001446-mpuovmeb 131 21 and and CC cord-001446-mpuovmeb 131 22 serum serum NN cord-001446-mpuovmeb 131 23 pneumoproteins pneumoprotein NNS cord-001446-mpuovmeb 131 24 in in IN cord-001446-mpuovmeb 131 25 asymptomatic asymptomatic JJ cord-001446-mpuovmeb 131 26 smokers smoker NNS cord-001446-mpuovmeb 131 27 and and CC cord-001446-mpuovmeb 131 28 patients patient NNS cord-001446-mpuovmeb 131 29 with with IN cord-001446-mpuovmeb 131 30 COPD COPD NNP cord-001446-mpuovmeb 131 31 or or CC cord-001446-mpuovmeb 131 32 asthma asthma NN cord-001446-mpuovmeb 131 33 Circulating circulate VBG cord-001446-mpuovmeb 131 34 surfactant surfactant NN cord-001446-mpuovmeb 131 35 protein protein NN cord-001446-mpuovmeb 131 36 D D NNP cord-001446-mpuovmeb 131 37 as as IN cord-001446-mpuovmeb 131 38 a a DT cord-001446-mpuovmeb 131 39 potential potential JJ cord-001446-mpuovmeb 131 40 lung lung NN cord-001446-mpuovmeb 131 41 - - HYPH cord-001446-mpuovmeb 131 42 specific specific JJ cord-001446-mpuovmeb 131 43 biomarker biomarker NN cord-001446-mpuovmeb 131 44 of of IN cord-001446-mpuovmeb 131 45 health health NN cord-001446-mpuovmeb 131 46 outcomes outcome NNS cord-001446-mpuovmeb 131 47 in in IN cord-001446-mpuovmeb 131 48 COPD COPD NNP cord-001446-mpuovmeb 131 49 : : : cord-001446-mpuovmeb 131 50 a a DT cord-001446-mpuovmeb 131 51 pilot pilot NN cord-001446-mpuovmeb 131 52 study study NN cord-001446-mpuovmeb 132 1 The the DT cord-001446-mpuovmeb 132 2 effects effect NNS cord-001446-mpuovmeb 132 3 of of IN cord-001446-mpuovmeb 132 4 fluticasone fluticasone NN cord-001446-mpuovmeb 132 5 with with IN cord-001446-mpuovmeb 132 6 or or CC cord-001446-mpuovmeb 132 7 without without IN cord-001446-mpuovmeb 132 8 salmeterol salmeterol NN cord-001446-mpuovmeb 132 9 on on IN cord-001446-mpuovmeb 132 10 systemic systemic JJ cord-001446-mpuovmeb 132 11 biomarkers biomarker NNS cord-001446-mpuovmeb 132 12 of of IN cord-001446-mpuovmeb 132 13 inflammation inflammation NN cord-001446-mpuovmeb 132 14 in in IN cord-001446-mpuovmeb 132 15 chronic chronic JJ cord-001446-mpuovmeb 132 16 obstructive obstructive JJ cord-001446-mpuovmeb 132 17 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 18 disease disease NN cord-001446-mpuovmeb 132 19 Serum Serum NNP cord-001446-mpuovmeb 132 20 surfactant surfactant NN cord-001446-mpuovmeb 132 21 protein protein NN cord-001446-mpuovmeb 132 22 D D NNP cord-001446-mpuovmeb 132 23 is be VBZ cord-001446-mpuovmeb 132 24 steroid steroid NN cord-001446-mpuovmeb 132 25 sensitive sensitive JJ cord-001446-mpuovmeb 132 26 and and CC cord-001446-mpuovmeb 132 27 associated associate VBN cord-001446-mpuovmeb 132 28 with with IN cord-001446-mpuovmeb 132 29 exacerbations exacerbation NNS cord-001446-mpuovmeb 132 30 of of IN cord-001446-mpuovmeb 132 31 COPD COPD NNP cord-001446-mpuovmeb 132 32 Serum Serum NNP cord-001446-mpuovmeb 132 33 surfactant surfactant NN cord-001446-mpuovmeb 132 34 protein protein NN cord-001446-mpuovmeb 132 35 D d NN cord-001446-mpuovmeb 132 36 during during IN cord-001446-mpuovmeb 132 37 acute acute JJ cord-001446-mpuovmeb 132 38 exacerbations exacerbation NNS cord-001446-mpuovmeb 132 39 of of IN cord-001446-mpuovmeb 132 40 chronic chronic JJ cord-001446-mpuovmeb 132 41 obstructive obstructive JJ cord-001446-mpuovmeb 132 42 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 43 disease disease NN cord-001446-mpuovmeb 132 44 Comprehensive comprehensive JJ cord-001446-mpuovmeb 132 45 characterisation characterisation NN cord-001446-mpuovmeb 132 46 of of IN cord-001446-mpuovmeb 132 47 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 48 and and CC cord-001446-mpuovmeb 132 49 serum serum NN cord-001446-mpuovmeb 132 50 surfactant surfactant NN cord-001446-mpuovmeb 132 51 protein protein NN cord-001446-mpuovmeb 132 52 D D NNP cord-001446-mpuovmeb 132 53 in in IN cord-001446-mpuovmeb 132 54 COPD COPD NNP cord-001446-mpuovmeb 132 55 Serum Serum NNP cord-001446-mpuovmeb 132 56 surfactant surfactant NN cord-001446-mpuovmeb 132 57 protein protein NN cord-001446-mpuovmeb 132 58 D d NN cord-001446-mpuovmeb 132 59 : : : cord-001446-mpuovmeb 132 60 biomarker biomarker NN cord-001446-mpuovmeb 132 61 of of IN cord-001446-mpuovmeb 132 62 chronic chronic JJ cord-001446-mpuovmeb 132 63 obstructive obstructive JJ cord-001446-mpuovmeb 132 64 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 65 disease disease NN cord-001446-mpuovmeb 132 66 Value Value NNP cord-001446-mpuovmeb 132 67 of of IN cord-001446-mpuovmeb 132 68 serum serum NN cord-001446-mpuovmeb 132 69 and and CC cord-001446-mpuovmeb 132 70 induced induce VBN cord-001446-mpuovmeb 132 71 sputum sputum NN cord-001446-mpuovmeb 132 72 surfactant surfactant NN cord-001446-mpuovmeb 132 73 protein protein NN cord-001446-mpuovmeb 132 74 - - HYPH cord-001446-mpuovmeb 132 75 D d NN cord-001446-mpuovmeb 132 76 in in IN cord-001446-mpuovmeb 132 77 chronic chronic JJ cord-001446-mpuovmeb 132 78 obstructive obstructive JJ cord-001446-mpuovmeb 132 79 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 80 disease disease NN cord-001446-mpuovmeb 132 81 Surfactant Surfactant NNP cord-001446-mpuovmeb 132 82 protein protein NN cord-001446-mpuovmeb 132 83 d d NN cord-001446-mpuovmeb 132 84 , , , cord-001446-mpuovmeb 132 85 soluble soluble JJ cord-001446-mpuovmeb 132 86 intercellular intercellular JJ cord-001446-mpuovmeb 132 87 adhesion adhesion NN cord-001446-mpuovmeb 132 88 molecule-1 molecule-1 NN cord-001446-mpuovmeb 132 89 and and CC cord-001446-mpuovmeb 132 90 highsensitivity highsensitivity NN cord-001446-mpuovmeb 132 91 C c NN cord-001446-mpuovmeb 132 92 - - HYPH cord-001446-mpuovmeb 132 93 reactive reactive JJ cord-001446-mpuovmeb 132 94 protein protein NN cord-001446-mpuovmeb 132 95 as as IN cord-001446-mpuovmeb 132 96 biomarkers biomarker NNS cord-001446-mpuovmeb 132 97 of of IN cord-001446-mpuovmeb 132 98 chronic chronic JJ cord-001446-mpuovmeb 132 99 obstructive obstructive JJ cord-001446-mpuovmeb 132 100 pulmonary pulmonary JJ cord-001446-mpuovmeb 132 101 disease disease NN cord-001446-mpuovmeb 133 1 The the DT cord-001446-mpuovmeb 133 2 role role NN cord-001446-mpuovmeb 133 3 of of IN cord-001446-mpuovmeb 133 4 matrix matrix NN cord-001446-mpuovmeb 133 5 metalloproteinase-9 metalloproteinase-9 NNP cord-001446-mpuovmeb 133 6 in in IN cord-001446-mpuovmeb 133 7 cigarette cigarette NN cord-001446-mpuovmeb 133 8 smoke smoke NN cord-001446-mpuovmeb 133 9 - - HYPH cord-001446-mpuovmeb 133 10 induced induce VBN cord-001446-mpuovmeb 133 11 emphysema emphysema NN cord-001446-mpuovmeb 133 12 Surfactant Surfactant NNP cord-001446-mpuovmeb 133 13 protein protein NN cord-001446-mpuovmeb 133 14 D d NN cord-001446-mpuovmeb 133 15 in in IN cord-001446-mpuovmeb 133 16 serum serum NN cord-001446-mpuovmeb 133 17 from from IN cord-001446-mpuovmeb 133 18 patients patient NNS cord-001446-mpuovmeb 133 19 with with IN cord-001446-mpuovmeb 133 20 allergic allergic JJ cord-001446-mpuovmeb 133 21 bronchopulmonary bronchopulmonary NNP cord-001446-mpuovmeb 133 22 aspergillosis aspergillosis NNP cord-001446-mpuovmeb 133 23 Serum serum NN cord-001446-mpuovmeb 133 24 - - HYPH cord-001446-mpuovmeb 133 25 surfactant surfactant NN cord-001446-mpuovmeb 133 26 SP SP NNP cord-001446-mpuovmeb 133 27 - - HYPH cord-001446-mpuovmeb 133 28 D D NNP cord-001446-mpuovmeb 133 29 correlates correlate VBZ cord-001446-mpuovmeb 133 30 inversely inversely RB cord-001446-mpuovmeb 133 31 to to IN cord-001446-mpuovmeb 133 32 lung lung NN cord-001446-mpuovmeb 133 33 function function NN cord-001446-mpuovmeb 133 34 in in IN cord-001446-mpuovmeb 133 35 cystic cystic JJ cord-001446-mpuovmeb 133 36 fibrosis fibrosis NN cord-001446-mpuovmeb 134 1 Circulating circulate VBG cord-001446-mpuovmeb 134 2 surfactant surfactant NN cord-001446-mpuovmeb 134 3 protein protein NN cord-001446-mpuovmeb 134 4 - - HYPH cord-001446-mpuovmeb 134 5 D d NN cord-001446-mpuovmeb 134 6 and and CC cord-001446-mpuovmeb 134 7 the the DT cord-001446-mpuovmeb 134 8 risk risk NN cord-001446-mpuovmeb 134 9 of of IN cord-001446-mpuovmeb 134 10 cardiovascular cardiovascular JJ cord-001446-mpuovmeb 134 11 morbidity morbidity NN cord-001446-mpuovmeb 134 12 and and CC cord-001446-mpuovmeb 134 13 mortality mortality NN cord-001446-mpuovmeb 135 1 The the DT cord-001446-mpuovmeb 135 2 utility utility NN cord-001446-mpuovmeb 135 3 of of IN cord-001446-mpuovmeb 135 4 lung lung NN cord-001446-mpuovmeb 135 5 epithelium epithelium NN cord-001446-mpuovmeb 135 6 specific specific JJ cord-001446-mpuovmeb 135 7 biomarkers biomarker NNS cord-001446-mpuovmeb 135 8 in in IN cord-001446-mpuovmeb 135 9 cardiac cardiac JJ cord-001446-mpuovmeb 135 10 surgery surgery NN cord-001446-mpuovmeb 135 11 : : : cord-001446-mpuovmeb 135 12 a a DT cord-001446-mpuovmeb 135 13 comparison comparison NN cord-001446-mpuovmeb 135 14 of of IN cord-001446-mpuovmeb 135 15 biomarker biomarker NN cord-001446-mpuovmeb 135 16 profiles profile NNS cord-001446-mpuovmeb 135 17 in in IN cord-001446-mpuovmeb 135 18 on on IN cord-001446-mpuovmeb 135 19 - - HYPH cord-001446-mpuovmeb 135 20 and and CC cord-001446-mpuovmeb 135 21 off off IN cord-001446-mpuovmeb 135 22 - - HYPH cord-001446-mpuovmeb 135 23 pump pump NN cord-001446-mpuovmeb 135 24 coronary coronary JJ cord-001446-mpuovmeb 135 25 bypass bypass NN cord-001446-mpuovmeb 135 26 surgery surgery NN cord-001446-mpuovmeb 135 27 Can Can MD cord-001446-mpuovmeb 135 28 serum serum NN cord-001446-mpuovmeb 135 29 surfactant surfactant NN cord-001446-mpuovmeb 135 30 protein protein NN cord-001446-mpuovmeb 135 31 D D NNP cord-001446-mpuovmeb 135 32 or or CC cord-001446-mpuovmeb 135 33 CC cc NN cord-001446-mpuovmeb 135 34 - - HYPH cord-001446-mpuovmeb 135 35 chemokine chemokine NN cord-001446-mpuovmeb 135 36 ligand ligand NN cord-001446-mpuovmeb 135 37 18 18 CD cord-001446-mpuovmeb 135 38 predict predict VBP cord-001446-mpuovmeb 135 39 outcome outcome NN cord-001446-mpuovmeb 135 40 of of IN cord-001446-mpuovmeb 135 41 interstitial interstitial JJ cord-001446-mpuovmeb 135 42 lung lung NN cord-001446-mpuovmeb 135 43 disease disease NN cord-001446-mpuovmeb 135 44 in in IN cord-001446-mpuovmeb 135 45 patients patient NNS cord-001446-mpuovmeb 135 46 with with IN cord-001446-mpuovmeb 135 47 early early JJ cord-001446-mpuovmeb 135 48 systemic systemic JJ cord-001446-mpuovmeb 135 49 sclerosis sclerosis NN cord-001446-mpuovmeb 135 50 ? ? . cord-001446-mpuovmeb 136 1 Serum serum NN cord-001446-mpuovmeb 136 2 levels level NNS cord-001446-mpuovmeb 136 3 of of IN cord-001446-mpuovmeb 136 4 surfactant surfactant NN cord-001446-mpuovmeb 136 5 proteins protein NNS cord-001446-mpuovmeb 136 6 A A NNP cord-001446-mpuovmeb 136 7 and and CC cord-001446-mpuovmeb 136 8 D d NN cord-001446-mpuovmeb 136 9 are be VBP cord-001446-mpuovmeb 136 10 useful useful JJ cord-001446-mpuovmeb 136 11 biomarkers biomarker NNS cord-001446-mpuovmeb 136 12 for for IN cord-001446-mpuovmeb 136 13 interstitial interstitial JJ cord-001446-mpuovmeb 136 14 lung lung NN cord-001446-mpuovmeb 136 15 disease disease NN cord-001446-mpuovmeb 136 16 in in IN cord-001446-mpuovmeb 136 17 patients patient NNS cord-001446-mpuovmeb 136 18 with with IN cord-001446-mpuovmeb 136 19 progressive progressive JJ cord-001446-mpuovmeb 136 20 systemic systemic JJ cord-001446-mpuovmeb 136 21 sclerosis sclerosis NN cord-001446-mpuovmeb 136 22 Clinical clinical JJ cord-001446-mpuovmeb 136 23 significance significance NN cord-001446-mpuovmeb 136 24 of of IN cord-001446-mpuovmeb 136 25 surfactant surfactant NN cord-001446-mpuovmeb 136 26 protein protein NN cord-001446-mpuovmeb 136 27 D D NNP cord-001446-mpuovmeb 136 28 as as IN cord-001446-mpuovmeb 136 29 a a DT cord-001446-mpuovmeb 136 30 serum serum NN cord-001446-mpuovmeb 136 31 marker marker NN cord-001446-mpuovmeb 136 32 for for IN cord-001446-mpuovmeb 136 33 evaluating evaluate VBG cord-001446-mpuovmeb 136 34 pulmonary pulmonary JJ cord-001446-mpuovmeb 136 35 fibrosis fibrosis NN cord-001446-mpuovmeb 136 36 in in IN cord-001446-mpuovmeb 136 37 patients patient NNS cord-001446-mpuovmeb 136 38 with with IN cord-001446-mpuovmeb 136 39 systemic systemic JJ cord-001446-mpuovmeb 136 40 sclerosis sclerosis NN cord-001446-mpuovmeb 136 41 Comparative comparative JJ cord-001446-mpuovmeb 136 42 study study NN cord-001446-mpuovmeb 136 43 of of IN cord-001446-mpuovmeb 136 44 serum serum NN cord-001446-mpuovmeb 136 45 surfactant surfactant NN cord-001446-mpuovmeb 136 46 protein protein NN cord-001446-mpuovmeb 136 47 - - HYPH cord-001446-mpuovmeb 136 48 D d JJ cord-001446-mpuovmeb 136 49 and and CC cord-001446-mpuovmeb 136 50 KL-6 kl-6 JJ cord-001446-mpuovmeb 136 51 concentrations concentration NNS cord-001446-mpuovmeb 136 52 in in IN cord-001446-mpuovmeb 136 53 patients patient NNS cord-001446-mpuovmeb 136 54 with with IN cord-001446-mpuovmeb 136 55 systemic systemic JJ cord-001446-mpuovmeb 136 56 sclerosis sclerosis NN cord-001446-mpuovmeb 136 57 as as IN cord-001446-mpuovmeb 136 58 markers marker NNS cord-001446-mpuovmeb 136 59 for for IN cord-001446-mpuovmeb 136 60 monitoring monitor VBG cord-001446-mpuovmeb 136 61 the the DT cord-001446-mpuovmeb 136 62 activity activity NN cord-001446-mpuovmeb 136 63 of of IN cord-001446-mpuovmeb 136 64 pulmonary pulmonary JJ cord-001446-mpuovmeb 136 65 fibrosis fibrosis NN cord-001446-mpuovmeb 136 66 Surfactant Surfactant NNP cord-001446-mpuovmeb 136 67 protein protein NN cord-001446-mpuovmeb 136 68 D d NN cord-001446-mpuovmeb 136 69 and and CC cord-001446-mpuovmeb 136 70 KL-6 KL-6 NNP cord-001446-mpuovmeb 136 71 as as IN cord-001446-mpuovmeb 136 72 serum serum NN cord-001446-mpuovmeb 136 73 biomarkers biomarker NNS cord-001446-mpuovmeb 136 74 of of IN cord-001446-mpuovmeb 136 75 interstitial interstitial JJ cord-001446-mpuovmeb 136 76 lung lung NN cord-001446-mpuovmeb 136 77 disease disease NN cord-001446-mpuovmeb 136 78 in in IN cord-001446-mpuovmeb 136 79 patients patient NNS cord-001446-mpuovmeb 136 80 with with IN cord-001446-mpuovmeb 136 81 scleroderma scleroderma NNS cord-001446-mpuovmeb 136 82 Clinical clinical JJ cord-001446-mpuovmeb 136 83 significance significance NN cord-001446-mpuovmeb 136 84 of of IN cord-001446-mpuovmeb 136 85 serum serum NN cord-001446-mpuovmeb 136 86 pulmonary pulmonary JJ cord-001446-mpuovmeb 136 87 surfactant surfactant NN cord-001446-mpuovmeb 136 88 proteins protein VBZ cord-001446-mpuovmeb 136 89 a a DT cord-001446-mpuovmeb 136 90 and and CC cord-001446-mpuovmeb 136 91 d d NN cord-001446-mpuovmeb 136 92 for for IN cord-001446-mpuovmeb 136 93 the the DT cord-001446-mpuovmeb 136 94 early early JJ cord-001446-mpuovmeb 136 95 detection detection NN cord-001446-mpuovmeb 136 96 of of IN cord-001446-mpuovmeb 136 97 radiation radiation NN cord-001446-mpuovmeb 136 98 pneumonitis pneumonitis NN cord-001446-mpuovmeb 136 99 Diagnostic diagnostic JJ cord-001446-mpuovmeb 136 100 significance significance NN cord-001446-mpuovmeb 136 101 of of IN cord-001446-mpuovmeb 136 102 surfactant surfactant NN cord-001446-mpuovmeb 136 103 proteins protein NNS cord-001446-mpuovmeb 136 104 A A NNP cord-001446-mpuovmeb 136 105 and and CC cord-001446-mpuovmeb 136 106 D D NNP cord-001446-mpuovmeb 136 107 in in IN cord-001446-mpuovmeb 136 108 sera sera NNP cord-001446-mpuovmeb 136 109 from from IN cord-001446-mpuovmeb 136 110 patients patient NNS cord-001446-mpuovmeb 136 111 with with IN cord-001446-mpuovmeb 136 112 radiation radiation NN cord-001446-mpuovmeb 136 113 pneumonitis pneumonitis NN cord-001446-mpuovmeb 136 114 Study Study NNP cord-001446-mpuovmeb 136 115 of of IN cord-001446-mpuovmeb 136 116 Clara Clara NNP cord-001446-mpuovmeb 136 117 cell cell NN cord-001446-mpuovmeb 136 118 16 16 CD cord-001446-mpuovmeb 136 119 , , , cord-001446-mpuovmeb 136 120 KL-6 kl-6 JJ cord-001446-mpuovmeb 136 121 , , , cord-001446-mpuovmeb 136 122 and and CC cord-001446-mpuovmeb 136 123 surfactant surfactant NN cord-001446-mpuovmeb 136 124 protein protein NN cord-001446-mpuovmeb 136 125 - - HYPH cord-001446-mpuovmeb 136 126 D d NN cord-001446-mpuovmeb 136 127 in in IN cord-001446-mpuovmeb 136 128 serum serum NN cord-001446-mpuovmeb 136 129 as as IN cord-001446-mpuovmeb 136 130 disease disease NN cord-001446-mpuovmeb 136 131 markers marker NNS cord-001446-mpuovmeb 136 132 in in IN cord-001446-mpuovmeb 136 133 pulmonary pulmonary JJ cord-001446-mpuovmeb 136 134 sarcoidosis sarcoidosis NN cord-001446-mpuovmeb 136 135 Serum serum NN cord-001446-mpuovmeb 136 136 surfactant surfactant NN cord-001446-mpuovmeb 136 137 protein protein NN cord-001446-mpuovmeb 136 138 D D NNP cord-001446-mpuovmeb 136 139 is be VBZ cord-001446-mpuovmeb 136 140 elevated elevate VBN cord-001446-mpuovmeb 136 141 in in IN cord-001446-mpuovmeb 136 142 allergic allergic JJ cord-001446-mpuovmeb 136 143 patients patient NNS cord-001446-mpuovmeb 136 144 Involvement Involvement NNP cord-001446-mpuovmeb 136 145 of of IN cord-001446-mpuovmeb 136 146 eicosanoids eicosanoid NNS cord-001446-mpuovmeb 136 147 and and CC cord-001446-mpuovmeb 136 148 surfactant surfactant NN cord-001446-mpuovmeb 136 149 protein protein NN cord-001446-mpuovmeb 136 150 D d NN cord-001446-mpuovmeb 136 151 in in IN cord-001446-mpuovmeb 136 152 extrinsic extrinsic JJ cord-001446-mpuovmeb 136 153 allergic allergic JJ cord-001446-mpuovmeb 136 154 alveolitis alveolitis NN cord-001446-mpuovmeb 136 155 Functional functional JJ cord-001446-mpuovmeb 136 156 and and CC cord-001446-mpuovmeb 136 157 biological biological JJ cord-001446-mpuovmeb 136 158 characteristics characteristic NNS cord-001446-mpuovmeb 136 159 of of IN cord-001446-mpuovmeb 136 160 asthma asthma NN cord-001446-mpuovmeb 136 161 in in IN cord-001446-mpuovmeb 136 162 cleaning clean VBG cord-001446-mpuovmeb 136 163 workers worker NNS cord-001446-mpuovmeb 137 1 Circulating circulate VBG cord-001446-mpuovmeb 137 2 surfactant surfactant NN cord-001446-mpuovmeb 137 3 protein protein NN cord-001446-mpuovmeb 137 4 D d NN cord-001446-mpuovmeb 137 5 is be VBZ cord-001446-mpuovmeb 137 6 decreased decrease VBN cord-001446-mpuovmeb 137 7 in in IN cord-001446-mpuovmeb 137 8 early early JJ cord-001446-mpuovmeb 137 9 rheumatoid rheumatoid NN cord-001446-mpuovmeb 137 10 arthritis arthritis NN cord-001446-mpuovmeb 137 11 : : : cord-001446-mpuovmeb 138 1 a a DT cord-001446-mpuovmeb 138 2 1-year 1-year CD cord-001446-mpuovmeb 138 3 prospective prospective JJ cord-001446-mpuovmeb 138 4 study study NN cord-001446-mpuovmeb 138 5 Circulating circulate VBG cord-001446-mpuovmeb 138 6 surfactant surfactant NN cord-001446-mpuovmeb 138 7 protein protein NN cord-001446-mpuovmeb 138 8 -D -D : cord-001446-mpuovmeb 138 9 is be VBZ cord-001446-mpuovmeb 138 10 low low JJ cord-001446-mpuovmeb 138 11 and and CC cord-001446-mpuovmeb 138 12 correlates correlate VBZ cord-001446-mpuovmeb 138 13 negatively negatively RB cord-001446-mpuovmeb 138 14 with with IN cord-001446-mpuovmeb 138 15 systemic systemic JJ cord-001446-mpuovmeb 138 16 inflammation inflammation NN cord-001446-mpuovmeb 138 17 in in IN cord-001446-mpuovmeb 138 18 early early JJ cord-001446-mpuovmeb 138 19 , , , cord-001446-mpuovmeb 138 20 untreated untreated JJ cord-001446-mpuovmeb 138 21 rheumatoid rheumatoid NN cord-001446-mpuovmeb 138 22 arthritis arthritis NN cord-001446-mpuovmeb 138 23 Elevated elevated JJ cord-001446-mpuovmeb 138 24 plasma plasma NN cord-001446-mpuovmeb 138 25 surfactant surfactant NN cord-001446-mpuovmeb 138 26 protein protein NN cord-001446-mpuovmeb 138 27 D D NNP cord-001446-mpuovmeb 138 28 ( ( -LRB- cord-001446-mpuovmeb 138 29 SP SP NNP cord-001446-mpuovmeb 138 30 - - HYPH cord-001446-mpuovmeb 138 31 D D NNP cord-001446-mpuovmeb 138 32 ) ) -RRB- cord-001446-mpuovmeb 138 33 levels level NNS cord-001446-mpuovmeb 138 34 and and CC cord-001446-mpuovmeb 138 35 a a DT cord-001446-mpuovmeb 138 36 direct direct JJ cord-001446-mpuovmeb 138 37 correlation correlation NN cord-001446-mpuovmeb 138 38 with with IN cord-001446-mpuovmeb 138 39 anti anti JJ cord-001446-mpuovmeb 138 40 - - JJ cord-001446-mpuovmeb 138 41 severe severe JJ cord-001446-mpuovmeb 138 42 acute acute JJ cord-001446-mpuovmeb 138 43 respiratory respiratory JJ cord-001446-mpuovmeb 138 44 syndrome syndrome NN cord-001446-mpuovmeb 138 45 coronavirus coronavirus NN cord-001446-mpuovmeb 138 46 - - HYPH cord-001446-mpuovmeb 138 47 specific specific JJ cord-001446-mpuovmeb 138 48 IgG igg NN cord-001446-mpuovmeb 138 49 antibody antibody NN cord-001446-mpuovmeb 138 50 in in IN cord-001446-mpuovmeb 138 51 SARS SARS NNP cord-001446-mpuovmeb 138 52 patients patient NNS cord-001446-mpuovmeb 138 53 Analysis Analysis NNP cord-001446-mpuovmeb 138 54 of of IN cord-001446-mpuovmeb 138 55 plasma plasma NN cord-001446-mpuovmeb 138 56 surfactant surfactant NN cord-001446-mpuovmeb 138 57 protein protein NN cord-001446-mpuovmeb 138 58 D d NN cord-001446-mpuovmeb 138 59 levels level NNS cord-001446-mpuovmeb 138 60 in in IN cord-001446-mpuovmeb 138 61 lung lung NN cord-001446-mpuovmeb 138 62 transplant transplant NN cord-001446-mpuovmeb 138 63 recipients recipient NNS cord-001446-mpuovmeb 138 64 Clinical clinical JJ cord-001446-mpuovmeb 138 65 significance significance NN cord-001446-mpuovmeb 138 66 of of IN cord-001446-mpuovmeb 138 67 the the DT cord-001446-mpuovmeb 138 68 serum serum NN cord-001446-mpuovmeb 138 69 surfactant surfactant NN cord-001446-mpuovmeb 138 70 protein protein NN cord-001446-mpuovmeb 138 71 D D NNP cord-001446-mpuovmeb 138 72 and and CC cord-001446-mpuovmeb 138 73 KL-6 kl-6 JJ cord-001446-mpuovmeb 138 74 levels level NNS cord-001446-mpuovmeb 138 75 in in IN cord-001446-mpuovmeb 138 76 patients patient NNS cord-001446-mpuovmeb 138 77 with with IN cord-001446-mpuovmeb 138 78 measles measle NNS cord-001446-mpuovmeb 138 79 complicated complicate VBN cord-001446-mpuovmeb 138 80 by by IN cord-001446-mpuovmeb 138 81 interstitial interstitial JJ cord-001446-mpuovmeb 138 82 pneumonia pneumonia NN cord-001446-mpuovmeb 138 83 Surfactant Surfactant NNP cord-001446-mpuovmeb 138 84 protein protein NN cord-001446-mpuovmeb 138 85 D d NN cord-001446-mpuovmeb 138 86 ( ( -LRB- cord-001446-mpuovmeb 138 87 SP SP NNP cord-001446-mpuovmeb 138 88 - - HYPH cord-001446-mpuovmeb 138 89 D D NNP cord-001446-mpuovmeb 138 90 ) ) -RRB- cord-001446-mpuovmeb 138 91 serum serum NN cord-001446-mpuovmeb 138 92 levels level NNS cord-001446-mpuovmeb 138 93 in in IN cord-001446-mpuovmeb 138 94 patients patient NNS cord-001446-mpuovmeb 138 95 with with IN cord-001446-mpuovmeb 138 96 community community NN cord-001446-mpuovmeb 138 97 - - HYPH cord-001446-mpuovmeb 138 98 acquired acquire VBN cord-001446-mpuovmeb 138 99 pneumonia pneumonia NN cord-001446-mpuovmeb 138 100 small small JJ cord-001446-mpuovmeb 138 101 star star NN cord-001446-mpuovmeb 138 102 , , , cord-001446-mpuovmeb 138 103 filled fill VBD cord-001446-mpuovmeb 138 104 Serum serum NN cord-001446-mpuovmeb 138 105 SP sp NN cord-001446-mpuovmeb 138 106 - - HYPH cord-001446-mpuovmeb 138 107 D d JJ cord-001446-mpuovmeb 138 108 levels level NNS cord-001446-mpuovmeb 138 109 as as IN cord-001446-mpuovmeb 138 110 a a DT cord-001446-mpuovmeb 138 111 biomarker biomarker NN cord-001446-mpuovmeb 138 112 of of IN cord-001446-mpuovmeb 138 113 lung lung NN cord-001446-mpuovmeb 138 114 injury injury NN cord-001446-mpuovmeb 138 115 in in IN cord-001446-mpuovmeb 138 116 respiratory respiratory JJ cord-001446-mpuovmeb 138 117 syncytial syncytial JJ cord-001446-mpuovmeb 138 118 virus virus NN cord-001446-mpuovmeb 138 119 bronchiolitis bronchiolitis NN cord-001446-mpuovmeb 138 120 Serum Serum NNP cord-001446-mpuovmeb 138 121 KL-6 KL-6 NNP cord-001446-mpuovmeb 138 122 and and CC cord-001446-mpuovmeb 138 123 surfactant surfactant NN cord-001446-mpuovmeb 138 124 protein protein NN cord-001446-mpuovmeb 138 125 D D NNP cord-001446-mpuovmeb 138 126 in in IN cord-001446-mpuovmeb 138 127 children child NNS cord-001446-mpuovmeb 138 128 with with IN cord-001446-mpuovmeb 138 129 2009 2009 CD cord-001446-mpuovmeb 138 130 pandemic pandemic NN cord-001446-mpuovmeb 138 131 H1N1 H1N1 NNP cord-001446-mpuovmeb 138 132 influenza influenza NN cord-001446-mpuovmeb 138 133 infection infection NN cord-001446-mpuovmeb 138 134 Serum serum NN cord-001446-mpuovmeb 139 1 KL-6 kl-6 JJ cord-001446-mpuovmeb 139 2 and and CC cord-001446-mpuovmeb 139 3 surfactant surfactant NN cord-001446-mpuovmeb 139 4 proteins protein NNS cord-001446-mpuovmeb 139 5 A A NNP cord-001446-mpuovmeb 139 6 and and CC cord-001446-mpuovmeb 139 7 D d NN cord-001446-mpuovmeb 139 8 in in IN cord-001446-mpuovmeb 139 9 pediatric pediatric JJ cord-001446-mpuovmeb 139 10 interstitial interstitial JJ cord-001446-mpuovmeb 139 11 lung lung NN cord-001446-mpuovmeb 139 12 disease disease NN cord-001446-mpuovmeb 139 13 Polymorphisms Polymorphisms NNP cord-001446-mpuovmeb 139 14 in in IN cord-001446-mpuovmeb 139 15 the the DT cord-001446-mpuovmeb 139 16 human human JJ cord-001446-mpuovmeb 139 17 surfactant surfactant NN cord-001446-mpuovmeb 139 18 protein protein NN cord-001446-mpuovmeb 139 19 - - HYPH cord-001446-mpuovmeb 139 20 D d JJ cord-001446-mpuovmeb 139 21 ( ( -LRB- cord-001446-mpuovmeb 139 22 SFTPD SFTPD NNP cord-001446-mpuovmeb 139 23 ) ) -RRB- cord-001446-mpuovmeb 139 24 gene gene NN cord-001446-mpuovmeb 139 25 : : : cord-001446-mpuovmeb 139 26 strong strong JJ cord-001446-mpuovmeb 139 27 evidence evidence NN cord-001446-mpuovmeb 139 28 that that IN cord-001446-mpuovmeb 139 29 serum serum NN cord-001446-mpuovmeb 139 30 levels level NNS cord-001446-mpuovmeb 139 31 of of IN cord-001446-mpuovmeb 139 32 surfactant surfactant NN cord-001446-mpuovmeb 139 33 protein protein NN cord-001446-mpuovmeb 139 34 - - HYPH cord-001446-mpuovmeb 139 35 D d JJ cord-001446-mpuovmeb 139 36 ( ( -LRB- cord-001446-mpuovmeb 139 37 SP SP NNP cord-001446-mpuovmeb 139 38 - - HYPH cord-001446-mpuovmeb 139 39 D D NNP cord-001446-mpuovmeb 139 40 ) ) -RRB- cord-001446-mpuovmeb 139 41 are be VBP cord-001446-mpuovmeb 139 42 genetically genetically RB cord-001446-mpuovmeb 139 43 influenced influence VBN cord-001446-mpuovmeb 139 44 Surfactant Surfactant NNP cord-001446-mpuovmeb 139 45 protein protein NN cord-001446-mpuovmeb 139 46 d d NN cord-001446-mpuovmeb 139 47 , , , cord-001446-mpuovmeb 139 48 a a DT cord-001446-mpuovmeb 139 49 marker marker NN cord-001446-mpuovmeb 139 50 of of IN cord-001446-mpuovmeb 139 51 lung lung NN cord-001446-mpuovmeb 139 52 innate innate JJ cord-001446-mpuovmeb 139 53 immunity immunity NN cord-001446-mpuovmeb 139 54 , , , cord-001446-mpuovmeb 139 55 is be VBZ cord-001446-mpuovmeb 139 56 positively positively RB cord-001446-mpuovmeb 139 57 associated associate VBN cord-001446-mpuovmeb 139 58 with with IN cord-001446-mpuovmeb 139 59 insulin insulin NN cord-001446-mpuovmeb 139 60 sensitivity sensitivity NN cord-001446-mpuovmeb 139 61 Circulating circulate VBG cord-001446-mpuovmeb 139 62 levels level NNS cord-001446-mpuovmeb 139 63 of of IN cord-001446-mpuovmeb 139 64 Clara Clara NNP cord-001446-mpuovmeb 139 65 cell cell NN cord-001446-mpuovmeb 139 66 protein protein NN cord-001446-mpuovmeb 139 67 16 16 CD cord-001446-mpuovmeb 139 68 but but CC cord-001446-mpuovmeb 140 1 not not RB cord-001446-mpuovmeb 140 2 surfactant surfactant NN cord-001446-mpuovmeb 140 3 protein protein NN cord-001446-mpuovmeb 140 4 D d NN cord-001446-mpuovmeb 140 5 identify identify VBP cord-001446-mpuovmeb 140 6 and and CC cord-001446-mpuovmeb 140 7 quantify quantify VB cord-001446-mpuovmeb 140 8 lung lung NN cord-001446-mpuovmeb 140 9 damage damage NN cord-001446-mpuovmeb 140 10 in in IN cord-001446-mpuovmeb 140 11 patients patient NNS cord-001446-mpuovmeb 140 12 with with IN cord-001446-mpuovmeb 140 13 multiple multiple JJ cord-001446-mpuovmeb 140 14 injuries injury NNS cord-001446-mpuovmeb 140 15 Blood blood NN cord-001446-mpuovmeb 140 16 biomarkers biomarker NNS cord-001446-mpuovmeb 140 17 and and CC cord-001446-mpuovmeb 140 18 measures measure NNS cord-001446-mpuovmeb 140 19 of of IN cord-001446-mpuovmeb 140 20 pulmonary pulmonary JJ cord-001446-mpuovmeb 140 21 function function NN cord-001446-mpuovmeb 140 22 - - : cord-001446-mpuovmeb 140 23 a a DT cord-001446-mpuovmeb 140 24 study study NN cord-001446-mpuovmeb 140 25 from from IN cord-001446-mpuovmeb 140 26 the the DT cord-001446-mpuovmeb 140 27 Swedish swedish JJ cord-001446-mpuovmeb 140 28 twin twin NN cord-001446-mpuovmeb 140 29 registry registry NN cord-001446-mpuovmeb 141 1 Surfactant surfactant NN cord-001446-mpuovmeb 141 2 protein protein NN cord-001446-mpuovmeb 141 3 D d NN cord-001446-mpuovmeb 141 4 of of IN cord-001446-mpuovmeb 141 5 the the DT cord-001446-mpuovmeb 141 6 innate innate JJ cord-001446-mpuovmeb 141 7 immune immune JJ cord-001446-mpuovmeb 141 8 defence defence NN cord-001446-mpuovmeb 141 9 is be VBZ cord-001446-mpuovmeb 141 10 inversely inversely RB cord-001446-mpuovmeb 141 11 associated associate VBN cord-001446-mpuovmeb 141 12 with with IN cord-001446-mpuovmeb 141 13 human human JJ cord-001446-mpuovmeb 141 14 obesity obesity NN cord-001446-mpuovmeb 141 15 and and CC cord-001446-mpuovmeb 141 16 SP SP NNP cord-001446-mpuovmeb 141 17 - - HYPH cord-001446-mpuovmeb 141 18 D d JJ cord-001446-mpuovmeb 141 19 deficiency deficiency NN cord-001446-mpuovmeb 141 20 infers infer VBZ cord-001446-mpuovmeb 141 21 increased increase VBN cord-001446-mpuovmeb 141 22 body body NN cord-001446-mpuovmeb 141 23 weight weight NN cord-001446-mpuovmeb 141 24 in in IN cord-001446-mpuovmeb 141 25 mice mice NN cord-001446-mpuovmeb 141 26 Long long JJ cord-001446-mpuovmeb 141 27 - - HYPH cord-001446-mpuovmeb 141 28 term term NN cord-001446-mpuovmeb 141 29 stability stability NN cord-001446-mpuovmeb 141 30 and and CC cord-001446-mpuovmeb 141 31 circadian circadian NN cord-001446-mpuovmeb 141 32 variation variation NN cord-001446-mpuovmeb 141 33 in in IN cord-001446-mpuovmeb 141 34 circulating circulate VBG cord-001446-mpuovmeb 141 35 levels level NNS cord-001446-mpuovmeb 141 36 of of IN cord-001446-mpuovmeb 141 37 surfactant surfactant NN cord-001446-mpuovmeb 141 38 protein protein NN cord-001446-mpuovmeb 141 39 D D NNP cord-001446-mpuovmeb 141 40 A a DT cord-001446-mpuovmeb 141 41 common common JJ cord-001446-mpuovmeb 141 42 polymorphism polymorphism NN cord-001446-mpuovmeb 141 43 in in IN cord-001446-mpuovmeb 141 44 the the DT cord-001446-mpuovmeb 141 45 SFTPD SFTPD NNP cord-001446-mpuovmeb 141 46 gene gene NN cord-001446-mpuovmeb 141 47 influences influence NNS cord-001446-mpuovmeb 141 48 assembly assembly NN cord-001446-mpuovmeb 141 49 , , , cord-001446-mpuovmeb 141 50 function function NN cord-001446-mpuovmeb 141 51 , , , cord-001446-mpuovmeb 141 52 and and CC cord-001446-mpuovmeb 141 53 concentration concentration NN cord-001446-mpuovmeb 141 54 of of IN cord-001446-mpuovmeb 141 55 surfactant surfactant NN cord-001446-mpuovmeb 141 56 protein protein NN cord-001446-mpuovmeb 141 57 D D NNP cord-001446-mpuovmeb 141 58 Plasma Plasma NNP cord-001446-mpuovmeb 141 59 surfactant surfactant NN cord-001446-mpuovmeb 141 60 protein protein NN cord-001446-mpuovmeb 141 61 D d NN cord-001446-mpuovmeb 141 62 levels level NNS cord-001446-mpuovmeb 141 63 and and CC cord-001446-mpuovmeb 141 64 the the DT cord-001446-mpuovmeb 141 65 relation relation NN cord-001446-mpuovmeb 141 66 to to IN cord-001446-mpuovmeb 141 67 body body NN cord-001446-mpuovmeb 141 68 mass mass NN cord-001446-mpuovmeb 141 69 index index NN cord-001446-mpuovmeb 141 70 in in IN cord-001446-mpuovmeb 141 71 a a DT cord-001446-mpuovmeb 141 72 chinese chinese JJ cord-001446-mpuovmeb 141 73 population population NN cord-001446-mpuovmeb 141 74 Plasma Plasma NNP cord-001446-mpuovmeb 141 75 C3d C3d NNP cord-001446-mpuovmeb 141 76 levels level NNS cord-001446-mpuovmeb 141 77 of of IN cord-001446-mpuovmeb 141 78 young young JJ cord-001446-mpuovmeb 141 79 farmers farmer NNS cord-001446-mpuovmeb 141 80 correlate correlate VBP cord-001446-mpuovmeb 141 81 with with IN cord-001446-mpuovmeb 141 82 respirable respirable JJ cord-001446-mpuovmeb 141 83 dust dust NN cord-001446-mpuovmeb 141 84 exposure exposure NN cord-001446-mpuovmeb 141 85 levels level NNS cord-001446-mpuovmeb 141 86 during during IN cord-001446-mpuovmeb 141 87 normal normal JJ cord-001446-mpuovmeb 141 88 work work NN cord-001446-mpuovmeb 141 89 in in IN cord-001446-mpuovmeb 141 90 swine swine NN cord-001446-mpuovmeb 141 91 confinement confinement NN cord-001446-mpuovmeb 141 92 buildings building NNS cord-001446-mpuovmeb 141 93 Respiratory respiratory JJ cord-001446-mpuovmeb 141 94 effects effect NNS cord-001446-mpuovmeb 141 95 associated associate VBN cord-001446-mpuovmeb 141 96 with with IN cord-001446-mpuovmeb 141 97 wood wood NN cord-001446-mpuovmeb 141 98 fuel fuel NN cord-001446-mpuovmeb 141 99 use use NN cord-001446-mpuovmeb 141 100 : : : cord-001446-mpuovmeb 141 101 a a DT cord-001446-mpuovmeb 141 102 cross cross JJ cord-001446-mpuovmeb 141 103 - - JJ cord-001446-mpuovmeb 141 104 sectional sectional JJ cord-001446-mpuovmeb 141 105 biomarker biomarker NN cord-001446-mpuovmeb 141 106 study study NN cord-001446-mpuovmeb 141 107 among among IN cord-001446-mpuovmeb 141 108 adolescents adolescent NNS cord-001446-mpuovmeb 141 109 Roles Roles NNPS cord-001446-mpuovmeb 141 110 of of IN cord-001446-mpuovmeb 141 111 serum serum NNP cord-001446-mpuovmeb 141 112 clara clara NNP cord-001446-mpuovmeb 141 113 cell cell NN cord-001446-mpuovmeb 141 114 protein protein NN cord-001446-mpuovmeb 141 115 16 16 CD cord-001446-mpuovmeb 141 116 and and CC cord-001446-mpuovmeb 141 117 surfactant surfactant NN cord-001446-mpuovmeb 141 118 protein protein NN cord-001446-mpuovmeb 141 119 - - HYPH cord-001446-mpuovmeb 141 120 D d NN cord-001446-mpuovmeb 141 121 in in IN cord-001446-mpuovmeb 141 122 the the DT cord-001446-mpuovmeb 141 123 early early JJ cord-001446-mpuovmeb 141 124 diagnosis diagnosis NN cord-001446-mpuovmeb 141 125 and and CC cord-001446-mpuovmeb 141 126 progression progression NN cord-001446-mpuovmeb 141 127 of of IN cord-001446-mpuovmeb 141 128 silicosis silicosis NN cord-001446-mpuovmeb 141 129 Serum serum NN cord-001446-mpuovmeb 141 130 surfactant surfactant NN cord-001446-mpuovmeb 141 131 protein protein NN cord-001446-mpuovmeb 141 132 - - HYPH cord-001446-mpuovmeb 141 133 A a NN cord-001446-mpuovmeb 141 134 , , , cord-001446-mpuovmeb 141 135 but but CC cord-001446-mpuovmeb 141 136 not not RB cord-001446-mpuovmeb 141 137 surfactant surfactant NN cord-001446-mpuovmeb 141 138 protein protein NN cord-001446-mpuovmeb 141 139 - - HYPH cord-001446-mpuovmeb 141 140 D d JJ cord-001446-mpuovmeb 141 141 or or CC cord-001446-mpuovmeb 141 142 KL-6 KL-6 NNP cord-001446-mpuovmeb 141 143 , , , cord-001446-mpuovmeb 141 144 can can MD cord-001446-mpuovmeb 141 145 predict predict VB cord-001446-mpuovmeb 141 146 preclinical preclinical JJ cord-001446-mpuovmeb 141 147 lung lung NN cord-001446-mpuovmeb 141 148 damage damage NN cord-001446-mpuovmeb 141 149 induced induce VBN cord-001446-mpuovmeb 141 150 by by IN cord-001446-mpuovmeb 141 151 smoking smoke VBG cord-001446-mpuovmeb 141 152 Biomarkers Biomarkers NNPS cord-001446-mpuovmeb 141 153 of of IN cord-001446-mpuovmeb 141 154 early early JJ cord-001446-mpuovmeb 141 155 respiratory respiratory JJ cord-001446-mpuovmeb 141 156 effects effect NNS cord-001446-mpuovmeb 141 157 in in IN cord-001446-mpuovmeb 141 158 smoking smoke VBG cord-001446-mpuovmeb 141 159 adolescents adolescent NNS cord-001446-mpuovmeb 142 1 Circulating circulate VBG cord-001446-mpuovmeb 142 2 markers marker NNS cord-001446-mpuovmeb 142 3 of of IN cord-001446-mpuovmeb 142 4 interstitial interstitial JJ cord-001446-mpuovmeb 142 5 lung lung NN cord-001446-mpuovmeb 142 6 disease disease NN cord-001446-mpuovmeb 142 7 and and CC cord-001446-mpuovmeb 142 8 subsequent subsequent JJ cord-001446-mpuovmeb 142 9 risk risk NN cord-001446-mpuovmeb 142 10 of of IN cord-001446-mpuovmeb 142 11 lung lung NN cord-001446-mpuovmeb 142 12 cancer cancer NN cord-001446-mpuovmeb 142 13 Inhaled inhale VBD cord-001446-mpuovmeb 142 14 LPS LPS NNP cord-001446-mpuovmeb 142 15 challenges challenge NNS cord-001446-mpuovmeb 142 16 in in IN cord-001446-mpuovmeb 142 17 smokers smoker NNS cord-001446-mpuovmeb 142 18 : : : cord-001446-mpuovmeb 142 19 a a DT cord-001446-mpuovmeb 142 20 study study NN cord-001446-mpuovmeb 142 21 of of IN cord-001446-mpuovmeb 142 22 pulmonary pulmonary JJ cord-001446-mpuovmeb 142 23 and and CC cord-001446-mpuovmeb 142 24 systemic systemic JJ cord-001446-mpuovmeb 142 25 effects effect NNS cord-001446-mpuovmeb 142 26 Lung lung NN cord-001446-mpuovmeb 142 27 epithelium epithelium NN cord-001446-mpuovmeb 142 28 injury injury NN cord-001446-mpuovmeb 142 29 biomarkers biomarker NNS cord-001446-mpuovmeb 142 30 in in IN cord-001446-mpuovmeb 142 31 workers worker NNS cord-001446-mpuovmeb 142 32 exposed expose VBN cord-001446-mpuovmeb 142 33 to to IN cord-001446-mpuovmeb 142 34 sulphur sulphur NN cord-001446-mpuovmeb 142 35 dioxide dioxide NN cord-001446-mpuovmeb 142 36 in in IN cord-001446-mpuovmeb 142 37 a a DT cord-001446-mpuovmeb 142 38 nonferrous nonferrous JJ cord-001446-mpuovmeb 142 39 smelter smelter NN cord-001446-mpuovmeb 143 1 The the DT cord-001446-mpuovmeb 143 2 effects effect NNS cord-001446-mpuovmeb 143 3 of of IN cord-001446-mpuovmeb 143 4 GH gh NN cord-001446-mpuovmeb 143 5 and and CC cord-001446-mpuovmeb 143 6 hormone hormone NN cord-001446-mpuovmeb 143 7 replacement replacement NN cord-001446-mpuovmeb 143 8 therapy therapy NN cord-001446-mpuovmeb 143 9 on on IN cord-001446-mpuovmeb 143 10 serum serum NN cord-001446-mpuovmeb 143 11 concentrations concentration NNS cord-001446-mpuovmeb 143 12 of of IN cord-001446-mpuovmeb 143 13 mannan mannan NN cord-001446-mpuovmeb 143 14 - - HYPH cord-001446-mpuovmeb 143 15 binding bind VBG cord-001446-mpuovmeb 143 16 lectin lectin NN cord-001446-mpuovmeb 143 17 , , , cord-001446-mpuovmeb 143 18 surfactant surfactant NN cord-001446-mpuovmeb 143 19 protein protein NN cord-001446-mpuovmeb 143 20 D d NN cord-001446-mpuovmeb 143 21 and and CC cord-001446-mpuovmeb 143 22 vitamin vitamin NN cord-001446-mpuovmeb 143 23 D d NN cord-001446-mpuovmeb 143 24 binding bind VBG cord-001446-mpuovmeb 143 25 protein protein NN cord-001446-mpuovmeb 143 26 in in IN cord-001446-mpuovmeb 143 27 Turner Turner NNP cord-001446-mpuovmeb 143 28 syndrome syndrome NN cord-001446-mpuovmeb 143 29 Plasma Plasma NNP cord-001446-mpuovmeb 143 30 surfactant surfactant NN cord-001446-mpuovmeb 143 31 D d NN cord-001446-mpuovmeb 143 32 in in IN cord-001446-mpuovmeb 143 33 patients patient NNS cord-001446-mpuovmeb 143 34 following follow VBG cord-001446-mpuovmeb 143 35 acute acute JJ cord-001446-mpuovmeb 143 36 paraquat paraquat JJ cord-001446-mpuovmeb 143 37 intoxication intoxication NN cord-001446-mpuovmeb 143 38 Respiratory respiratory JJ cord-001446-mpuovmeb 143 39 function function NN cord-001446-mpuovmeb 143 40 and and CC cord-001446-mpuovmeb 143 41 changes change NNS cord-001446-mpuovmeb 143 42 in in IN cord-001446-mpuovmeb 143 43 lung lung NN cord-001446-mpuovmeb 143 44 epithelium epithelium NN cord-001446-mpuovmeb 143 45 biomarkers biomarker NNS cord-001446-mpuovmeb 143 46 after after IN cord-001446-mpuovmeb 143 47 a a DT cord-001446-mpuovmeb 143 48 short short JJ cord-001446-mpuovmeb 143 49 - - HYPH cord-001446-mpuovmeb 143 50 training training NN cord-001446-mpuovmeb 143 51 intervention intervention NN cord-001446-mpuovmeb 143 52 in in IN cord-001446-mpuovmeb 143 53 chlorinated chlorinated JJ cord-001446-mpuovmeb 143 54 vs. vs. CC cord-001446-mpuovmeb 143 55 ozone ozone NN cord-001446-mpuovmeb 143 56 indoor indoor JJ cord-001446-mpuovmeb 143 57 pools pool NNS cord-001446-mpuovmeb 144 1 A a DT cord-001446-mpuovmeb 144 2 panel panel NN cord-001446-mpuovmeb 144 3 of of IN cord-001446-mpuovmeb 144 4 lung lung NN cord-001446-mpuovmeb 144 5 injury injury NN cord-001446-mpuovmeb 144 6 biomarkers biomarker NNS cord-001446-mpuovmeb 144 7 enhances enhance VBZ cord-001446-mpuovmeb 144 8 the the DT cord-001446-mpuovmeb 144 9 definition definition NN cord-001446-mpuovmeb 144 10 of of IN cord-001446-mpuovmeb 144 11 primary primary JJ cord-001446-mpuovmeb 144 12 graft graft NN cord-001446-mpuovmeb 144 13 dysfunction dysfunction NN cord-001446-mpuovmeb 144 14 ( ( -LRB- cord-001446-mpuovmeb 144 15 PGD PGD NNP cord-001446-mpuovmeb 144 16 ) ) -RRB- cord-001446-mpuovmeb 144 17 after after IN cord-001446-mpuovmeb 144 18 lung lung NN cord-001446-mpuovmeb 144 19 transplantation transplantation NN cord-001446-mpuovmeb 144 20 The the DT cord-001446-mpuovmeb 144 21 sitting sit VBG cord-001446-mpuovmeb 144 22 position position NN cord-001446-mpuovmeb 144 23 during during IN cord-001446-mpuovmeb 144 24 neurosurgical neurosurgical JJ cord-001446-mpuovmeb 144 25 procedures procedure NNS cord-001446-mpuovmeb 144 26 does do VBZ cord-001446-mpuovmeb 144 27 not not RB cord-001446-mpuovmeb 144 28 influence influence VB cord-001446-mpuovmeb 144 29 serum serum NN cord-001446-mpuovmeb 144 30 biomarkers biomarker NNS cord-001446-mpuovmeb 144 31 of of IN cord-001446-mpuovmeb 144 32 pulmonary pulmonary JJ cord-001446-mpuovmeb 144 33 parenchymal parenchymal NN cord-001446-mpuovmeb 144 34 injury injury NN cord-001446-mpuovmeb 144 35 A a DT cord-001446-mpuovmeb 144 36 sandwich sandwich NN cord-001446-mpuovmeb 144 37 enzyme enzyme NN cord-001446-mpuovmeb 144 38 immunoassay immunoassay NN cord-001446-mpuovmeb 144 39 for for IN cord-001446-mpuovmeb 144 40 pulmonary pulmonary JJ cord-001446-mpuovmeb 144 41 surfactant surfactant NN cord-001446-mpuovmeb 144 42 protein protein NN cord-001446-mpuovmeb 144 43 D D NNP cord-001446-mpuovmeb 144 44 and and CC cord-001446-mpuovmeb 144 45 measurement measurement NN cord-001446-mpuovmeb 144 46 of of IN cord-001446-mpuovmeb 144 47 its -PRON- PRP$ cord-001446-mpuovmeb 144 48 blood blood NN cord-001446-mpuovmeb 144 49 levels level NNS cord-001446-mpuovmeb 144 50 in in IN cord-001446-mpuovmeb 144 51 drowning drown VBG cord-001446-mpuovmeb 144 52 victims victim NNS cord-001446-mpuovmeb 144 53 Clinical clinical JJ cord-001446-mpuovmeb 144 54 significance significance NN cord-001446-mpuovmeb 144 55 of of IN cord-001446-mpuovmeb 144 56 serum serum NN cord-001446-mpuovmeb 144 57 surfactant surfactant NN cord-001446-mpuovmeb 144 58 protein protein NN cord-001446-mpuovmeb 144 59 D D NNP cord-001446-mpuovmeb 144 60 ( ( -LRB- cord-001446-mpuovmeb 144 61 SP SP NNP cord-001446-mpuovmeb 144 62 - - HYPH cord-001446-mpuovmeb 144 63 D D NNP cord-001446-mpuovmeb 144 64 ) ) -RRB- cord-001446-mpuovmeb 144 65 in in IN cord-001446-mpuovmeb 144 66 patients patient NNS cord-001446-mpuovmeb 144 67 with with IN cord-001446-mpuovmeb 144 68 polymyositis/ polymyositis/ CD cord-001446-mpuovmeb 144 69 dermatomyositis dermatomyositis NN cord-001446-mpuovmeb 144 70 : : : cord-001446-mpuovmeb 144 71 correlation correlation NN cord-001446-mpuovmeb 144 72 with with IN cord-001446-mpuovmeb 144 73 interstitial interstitial JJ cord-001446-mpuovmeb 144 74 lung lung NN cord-001446-mpuovmeb 144 75 disease disease NN cord-001446-mpuovmeb 144 76 Serum Serum NNP cord-001446-mpuovmeb 144 77 surfactant surfactant NN cord-001446-mpuovmeb 144 78 protein protein NN cord-001446-mpuovmeb 144 79 D D NNP cord-001446-mpuovmeb 144 80 is be VBZ cord-001446-mpuovmeb 144 81 correlated correlate VBN cord-001446-mpuovmeb 144 82 to to IN cord-001446-mpuovmeb 144 83 development development NN cord-001446-mpuovmeb 144 84 of of IN cord-001446-mpuovmeb 144 85 dementia dementia NN cord-001446-mpuovmeb 144 86 and and CC cord-001446-mpuovmeb 144 87 augmented augment VBN cord-001446-mpuovmeb 144 88 mortality mortality NN cord-001446-mpuovmeb 145 1 Circulating circulate VBG cord-001446-mpuovmeb 145 2 surfactant surfactant NN cord-001446-mpuovmeb 145 3 protein protein NN cord-001446-mpuovmeb 145 4 D d NN cord-001446-mpuovmeb 145 5 is be VBZ cord-001446-mpuovmeb 145 6 decreased decrease VBN cord-001446-mpuovmeb 145 7 in in IN cord-001446-mpuovmeb 145 8 systemic systemic JJ cord-001446-mpuovmeb 145 9 lupus lupus NN cord-001446-mpuovmeb 145 10 erythematosus erythematosus NN cord-001446-mpuovmeb 145 11 Comparison comparison NN cord-001446-mpuovmeb 145 12 of of IN cord-001446-mpuovmeb 145 13 biomarkers biomarker NNS cord-001446-mpuovmeb 145 14 of of IN cord-001446-mpuovmeb 145 15 subclinical subclinical JJ cord-001446-mpuovmeb 145 16 lung lung NN cord-001446-mpuovmeb 145 17 injury injury NN cord-001446-mpuovmeb 145 18 in in IN cord-001446-mpuovmeb 145 19 obstructive obstructive JJ cord-001446-mpuovmeb 145 20 sleep sleep NN cord-001446-mpuovmeb 145 21 apnea apnea NN cord-001446-mpuovmeb 145 22 Lung lung NN cord-001446-mpuovmeb 145 23 epithelium epithelium NN cord-001446-mpuovmeb 145 24 - - HYPH cord-001446-mpuovmeb 145 25 specific specific JJ cord-001446-mpuovmeb 145 26 proteins protein NNS cord-001446-mpuovmeb 145 27 : : : cord-001446-mpuovmeb 146 1 characteristics characteristic NNS cord-001446-mpuovmeb 146 2 and and CC cord-001446-mpuovmeb 146 3 potential potential JJ cord-001446-mpuovmeb 146 4 applications application NNS cord-001446-mpuovmeb 146 5 as as IN cord-001446-mpuovmeb 146 6 markers marker NNS cord-001446-mpuovmeb 146 7 The the DT cord-001446-mpuovmeb 146 8 association association NN cord-001446-mpuovmeb 146 9 between between IN cord-001446-mpuovmeb 146 10 BMI BMI NNP cord-001446-mpuovmeb 146 11 and and CC cord-001446-mpuovmeb 146 12 plasma plasma NN cord-001446-mpuovmeb 146 13 cytokine cytokine NN cord-001446-mpuovmeb 146 14 levels level NNS cord-001446-mpuovmeb 146 15 in in IN cord-001446-mpuovmeb 146 16 patients patient NNS cord-001446-mpuovmeb 146 17 with with IN cord-001446-mpuovmeb 146 18 acute acute JJ cord-001446-mpuovmeb 146 19 lung lung NN cord-001446-mpuovmeb 146 20 injury injury NN cord-001446-mpuovmeb 146 21 Characterization characterization NN cord-001446-mpuovmeb 146 22 and and CC cord-001446-mpuovmeb 146 23 prevention prevention NN cord-001446-mpuovmeb 146 24 of of IN cord-001446-mpuovmeb 146 25 the the DT cord-001446-mpuovmeb 146 26 adsorption adsorption NN cord-001446-mpuovmeb 146 27 of of IN cord-001446-mpuovmeb 146 28 surfactant surfactant NN cord-001446-mpuovmeb 146 29 protein protein NN cord-001446-mpuovmeb 146 30 D D NNP cord-001446-mpuovmeb 146 31 to to IN cord-001446-mpuovmeb 146 32 polypropylene polypropylene NNP cord-001446-mpuovmeb 146 33 Collectin Collectin NNP cord-001446-mpuovmeb 146 34 surfactant surfactant NN cord-001446-mpuovmeb 146 35 protein protein NN cord-001446-mpuovmeb 146 36 D d NN cord-001446-mpuovmeb 146 37 binds bind VBZ cord-001446-mpuovmeb 146 38 antibodies antibody NNS cord-001446-mpuovmeb 146 39 and and CC cord-001446-mpuovmeb 146 40 interlinks interlink NNS cord-001446-mpuovmeb 147 1 innate innate JJ cord-001446-mpuovmeb 147 2 and and CC cord-001446-mpuovmeb 147 3 adaptive adaptive JJ cord-001446-mpuovmeb 147 4 immune immune JJ cord-001446-mpuovmeb 147 5 systems system NNS cord-001446-mpuovmeb 147 6 Increased increase VBD cord-001446-mpuovmeb 147 7 prevalence prevalence NN cord-001446-mpuovmeb 147 8 of of IN cord-001446-mpuovmeb 147 9 low low JJ cord-001446-mpuovmeb 147 10 oligomeric oligomeric JJ cord-001446-mpuovmeb 147 11 state state NN cord-001446-mpuovmeb 147 12 surfactant surfactant NN cord-001446-mpuovmeb 147 13 protein protein NN cord-001446-mpuovmeb 147 14 D D NNP cord-001446-mpuovmeb 147 15 with with IN cord-001446-mpuovmeb 147 16 restricted restricted JJ cord-001446-mpuovmeb 147 17 lectin lectin NN cord-001446-mpuovmeb 147 18 activity activity NN cord-001446-mpuovmeb 147 19 in in IN cord-001446-mpuovmeb 147 20 bronchoalveolar bronchoalveolar NNP cord-001446-mpuovmeb 147 21 lavage lavage NN cord-001446-mpuovmeb 147 22 fluid fluid NN cord-001446-mpuovmeb 147 23 from from IN cord-001446-mpuovmeb 147 24 preterm preterm JJR cord-001446-mpuovmeb 147 25 infants infant NNS cord-001446-mpuovmeb 148 1 The the DT cord-001446-mpuovmeb 148 2 authors author NNS cord-001446-mpuovmeb 148 3 would would MD cord-001446-mpuovmeb 148 4 like like VB cord-001446-mpuovmeb 148 5 to to TO cord-001446-mpuovmeb 148 6 thank thank VB cord-001446-mpuovmeb 148 7 Tarek Tarek NNP cord-001446-mpuovmeb 148 8 Abdalla Abdalla NNP cord-001446-mpuovmeb 148 9 for for IN cord-001446-mpuovmeb 148 10 his -PRON- PRP$ cord-001446-mpuovmeb 148 11 assistance assistance NN cord-001446-mpuovmeb 148 12 with with IN cord-001446-mpuovmeb 148 13 sample sample NN cord-001446-mpuovmeb 148 14 collection collection NN cord-001446-mpuovmeb 148 15 and and CC cord-001446-mpuovmeb 148 16 processing processing NN cord-001446-mpuovmeb 148 17 . . . cord-001446-mpuovmeb 149 1 Conceived conceive VBN cord-001446-mpuovmeb 149 2 and and CC cord-001446-mpuovmeb 149 3 designed design VBD cord-001446-mpuovmeb 149 4 the the DT cord-001446-mpuovmeb 149 5 experiments experiment NNS cord-001446-mpuovmeb 149 6 : : : cord-001446-mpuovmeb 149 7 PEB PEB NNP cord-001446-mpuovmeb 149 8 . . . cord-001446-mpuovmeb 150 1 Performed perform VBN cord-001446-mpuovmeb 150 2 the the DT cord-001446-mpuovmeb 150 3 experiments experiment NNS cord-001446-mpuovmeb 150 4 : : : cord-001446-mpuovmeb 150 5 PEB PEB NNP cord-001446-mpuovmeb 150 6 . . . cord-001446-mpuovmeb 151 1 Analyzed analyze VBD cord-001446-mpuovmeb 151 2 the the DT cord-001446-mpuovmeb 151 3 data datum NNS cord-001446-mpuovmeb 151 4 : : : cord-001446-mpuovmeb 151 5 PEB PEB NNP cord-001446-mpuovmeb 151 6 . . . cord-001446-mpuovmeb 152 1 Contributed contribute VBN cord-001446-mpuovmeb 152 2 reagents reagent NNS cord-001446-mpuovmeb 152 3 / / SYM cord-001446-mpuovmeb 152 4 materials/ materials/ CD cord-001446-mpuovmeb 152 5 analysis analysis NN cord-001446-mpuovmeb 152 6 tools tool NNS cord-001446-mpuovmeb 152 7 : : : cord-001446-mpuovmeb 152 8 PEB PEB NNP cord-001446-mpuovmeb 152 9 AG AG NNP cord-001446-mpuovmeb 152 10 . . . cord-001446-mpuovmeb 153 1 Wrote write VBD cord-001446-mpuovmeb 153 2 the the DT cord-001446-mpuovmeb 153 3 paper paper NN cord-001446-mpuovmeb 153 4 : : : cord-001446-mpuovmeb 153 5 PEB PEB NNP cord-001446-mpuovmeb 153 6 AG AG NNP cord-001446-mpuovmeb 153 7 . . .