id	sid	tid	token	lemma	pos
cord-000947-psguw47w	1	1	key	key	JJ
cord-000947-psguw47w	1	2	:	:	:
cord-000947-psguw47w	1	3	cord-000947-psguw47w	cord-000947-psguw47w	CD
cord-000947-psguw47w	1	4	authors	author	NNS
cord-000947-psguw47w	1	5	:	:	:
cord-000947-psguw47w	1	6	Feng	Feng	NNP
cord-000947-psguw47w	1	7	,	,	,
cord-000947-psguw47w	1	8	Jianyu	Jianyu	NNP
cord-000947-psguw47w	1	9	;	;	:
cord-000947-psguw47w	1	10	Guo	Guo	NNP
cord-000947-psguw47w	1	11	,	,	,
cord-000947-psguw47w	1	12	Hong	Hong	NNP
cord-000947-psguw47w	1	13	;	;	:
cord-000947-psguw47w	1	14	Li	Li	NNP
cord-000947-psguw47w	1	15	,	,	,
cord-000947-psguw47w	1	16	Sen	Sen	NNP
cord-000947-psguw47w	1	17	;	;	:
cord-000947-psguw47w	1	18	Lu	Lu	NNP
cord-000947-psguw47w	1	19	,	,	,
cord-000947-psguw47w	1	20	Tun	Tun	NNP
cord-000947-psguw47w	1	21	title	title	NN
cord-000947-psguw47w	1	22	:	:	:
cord-000947-psguw47w	1	23	A	a	DT
cord-000947-psguw47w	1	24	Study	Study	NNP
cord-000947-psguw47w	1	25	of	of	IN
cord-000947-psguw47w	1	26	the	the	DT
cord-000947-psguw47w	1	27	Mechanism	Mechanism	NNP
cord-000947-psguw47w	1	28	of	of	IN
cord-000947-psguw47w	1	29	the	the	DT
cord-000947-psguw47w	1	30	Chaperone	Chaperone	NNP
cord-000947-psguw47w	1	31	-	-	HYPH
cord-000947-psguw47w	1	32	like	like	JJ
cord-000947-psguw47w	1	33	Function	function	NN
cord-000947-psguw47w	1	34	of	of	IN
cord-000947-psguw47w	1	35	an	an	DT
cord-000947-psguw47w	1	36	scFv	scfv	NN
cord-000947-psguw47w	1	37	of	of	IN
cord-000947-psguw47w	1	38	Human	Human	NNP
cord-000947-psguw47w	1	39	Creatine	Creatine	NNP
cord-000947-psguw47w	1	40	Kinase	Kinase	NNP
cord-000947-psguw47w	1	41	by	by	IN
cord-000947-psguw47w	1	42	Computer	Computer	NNP
cord-000947-psguw47w	1	43	Simulation	Simulation	NNP
cord-000947-psguw47w	1	44	date	date	NN
cord-000947-psguw47w	1	45	:	:	:
cord-000947-psguw47w	1	46	2013	2013	CD
cord-000947-psguw47w	1	47	-	-	HYPH
cord-000947-psguw47w	1	48	04	04	CD
cord-000947-psguw47w	1	49	-	-	HYPH
cord-000947-psguw47w	1	50	24	24	CD
cord-000947-psguw47w	1	51	journal	journal	NN
cord-000947-psguw47w	1	52	:	:	:
cord-000947-psguw47w	2	1	PLoS	PLoS	NNP
cord-000947-psguw47w	2	2	One	one	CD
cord-000947-psguw47w	2	3	DOI	DOI	NNP
cord-000947-psguw47w	2	4	:	:	:
cord-000947-psguw47w	2	5	10.1371	10.1371	CD
cord-000947-psguw47w	2	6	/	/	SYM
cord-000947-psguw47w	2	7	journal.pone.0062147	journal.pone.0062147	NNP
cord-000947-psguw47w	2	8	sha	sha	NNP
cord-000947-psguw47w	2	9	:	:	:
cord-000947-psguw47w	3	1	a0e91efcafa0a743be0342254943e8d31cd36558	a0e91efcafa0a743be0342254943e8d31cd36558	NNS
cord-000947-psguw47w	3	2	doc_id	doc_id	CD
cord-000947-psguw47w	3	3	:	:	:
cord-000947-psguw47w	3	4	947	947	CD
cord-000947-psguw47w	3	5	cord_uid	cord_uid	NN
cord-000947-psguw47w	3	6	:	:	:
cord-000947-psguw47w	4	1	psguw47w	psguw47w	XX
cord-000947-psguw47w	5	1	A	a	DT
cord-000947-psguw47w	5	2	new	new	JJ
cord-000947-psguw47w	5	3	application	application	NN
cord-000947-psguw47w	5	4	of	of	IN
cord-000947-psguw47w	5	5	antibodies	antibody	NNS
cord-000947-psguw47w	5	6	is	be	VBZ
cord-000947-psguw47w	5	7	to	to	TO
cord-000947-psguw47w	5	8	use	use	VB
cord-000947-psguw47w	5	9	them	-PRON-	PRP
cord-000947-psguw47w	5	10	as	as	IN
cord-000947-psguw47w	5	11	macromolecular	macromolecular	JJ
cord-000947-psguw47w	5	12	chaperones	chaperone	NNS
cord-000947-psguw47w	5	13	.	.	.
cord-000947-psguw47w	6	1	Protein	protein	NN
cord-000947-psguw47w	6	2	antigens	antigen	NNS
cord-000947-psguw47w	6	3	usually	usually	RB
cord-000947-psguw47w	6	4	have	have	VBP
cord-000947-psguw47w	6	5	multiple	multiple	JJ
cord-000947-psguw47w	6	6	epitopes	epitope	NNS
cord-000947-psguw47w	6	7	,	,	,
cord-000947-psguw47w	6	8	thus	thus	RB
cord-000947-psguw47w	6	9	,	,	,
cord-000947-psguw47w	6	10	there	there	EX
cord-000947-psguw47w	6	11	may	may	MD
cord-000947-psguw47w	6	12	be	be	VB
cord-000947-psguw47w	6	13	a	a	DT
cord-000947-psguw47w	6	14	plurality	plurality	NN
cord-000947-psguw47w	6	15	of	of	IN
cord-000947-psguw47w	6	16	antibodies	antibody	NNS
cord-000947-psguw47w	6	17	binding	bind	VBG
cord-000947-psguw47w	6	18	to	to	IN
cord-000947-psguw47w	6	19	one	one	CD
cord-000947-psguw47w	6	20	antigen	antigen	NN
cord-000947-psguw47w	6	21	.	.	.
cord-000947-psguw47w	7	1	However	however	RB
cord-000947-psguw47w	7	2	,	,	,
cord-000947-psguw47w	7	3	not	not	RB
cord-000947-psguw47w	7	4	all	all	DT
cord-000947-psguw47w	7	5	antibodies	antibody	NNS
cord-000947-psguw47w	7	6	that	that	WDT
cord-000947-psguw47w	7	7	bind	bind	VBP
cord-000947-psguw47w	7	8	to	to	IN
cord-000947-psguw47w	7	9	one	one	CD
cord-000947-psguw47w	7	10	antigen	antigen	NN
cord-000947-psguw47w	7	11	could	could	MD
cord-000947-psguw47w	7	12	act	act	VB
cord-000947-psguw47w	7	13	as	as	IN
cord-000947-psguw47w	7	14	a	a	DT
cord-000947-psguw47w	7	15	chaperone	chaperone	NN
cord-000947-psguw47w	7	16	.	.	.
cord-000947-psguw47w	8	1	Experiments	experiment	NNS
cord-000947-psguw47w	8	2	show	show	VBP
cord-000947-psguw47w	8	3	that	that	IN
cord-000947-psguw47w	8	4	some	some	DT
cord-000947-psguw47w	8	5	screened	screen	VBD
cord-000947-psguw47w	8	6	anti	anti	JJ
cord-000947-psguw47w	8	7	-	-	JJ
cord-000947-psguw47w	8	8	human	human	JJ
cord-000947-psguw47w	8	9	creatine	creatine	NN
cord-000947-psguw47w	8	10	kinase	kinase	VBD
cord-000947-psguw47w	8	11	single	single	JJ
cord-000947-psguw47w	8	12	chain	chain	NN
cord-000947-psguw47w	8	13	antibodies	antibody	NNS
cord-000947-psguw47w	8	14	(	(	-LRB-
cord-000947-psguw47w	8	15	scFV	scFV	NNP
cord-000947-psguw47w	8	16	)	)	-RRB-
cord-000947-psguw47w	8	17	could	could	MD
cord-000947-psguw47w	8	18	assist	assist	VB
cord-000947-psguw47w	8	19	in	in	IN
cord-000947-psguw47w	8	20	the	the	DT
cord-000947-psguw47w	8	21	folding	folding	NN
cord-000947-psguw47w	8	22	and	and	CC
cord-000947-psguw47w	8	23	stabilizing	stabilizing	NN
cord-000947-psguw47w	8	24	of	of	IN
cord-000947-psguw47w	8	25	the	the	DT
cord-000947-psguw47w	8	26	enzyme	enzyme	NN
cord-000947-psguw47w	8	27	,	,	,
cord-000947-psguw47w	8	28	while	while	IN
cord-000947-psguw47w	8	29	others	other	NNS
cord-000947-psguw47w	8	30	could	could	MD
cord-000947-psguw47w	8	31	not	not	RB
cord-000947-psguw47w	8	32	.	.	.
cord-000947-psguw47w	9	1	We	-PRON-	PRP
cord-000947-psguw47w	9	2	built	build	VBD
cord-000947-psguw47w	9	3	the	the	DT
cord-000947-psguw47w	9	4	model	model	NN
cord-000947-psguw47w	9	5	of	of	IN
cord-000947-psguw47w	9	6	the	the	DT
cord-000947-psguw47w	9	7	single	single	JJ
cord-000947-psguw47w	9	8	chain	chain	NN
cord-000947-psguw47w	9	9	antibody	antibody	NN
cord-000947-psguw47w	9	10	(	(	-LRB-
cord-000947-psguw47w	9	11	scFv	scFv	NNP
cord-000947-psguw47w	9	12	-	-	HYPH
cord-000947-psguw47w	9	13	A4	A4	NNP
cord-000947-psguw47w	9	14	)	)	-RRB-
cord-000947-psguw47w	9	15	that	that	WDT
cord-000947-psguw47w	9	16	increased	increase	VBD
cord-000947-psguw47w	9	17	the	the	DT
cord-000947-psguw47w	9	18	stability	stability	NN
cord-000947-psguw47w	9	19	of	of	IN
cord-000947-psguw47w	9	20	human	human	JJ
cord-000947-psguw47w	9	21	creatine	creatine	NN
cord-000947-psguw47w	9	22	kinase	kinase	NN
cord-000947-psguw47w	9	23	(	(	-LRB-
cord-000947-psguw47w	9	24	HCK	HCK	NNP
cord-000947-psguw47w	9	25	)	)	-RRB-
cord-000947-psguw47w	9	26	by	by	IN
cord-000947-psguw47w	9	27	the	the	DT
cord-000947-psguw47w	9	28	homology	homology	NN
cord-000947-psguw47w	9	29	modeling	modeling	NN
cord-000947-psguw47w	9	30	method	method	NN
cord-000947-psguw47w	9	31	.	.	.
cord-000947-psguw47w	10	1	Epitopes	Epitopes	NNP
cord-000947-psguw47w	10	2	of	of	IN
cord-000947-psguw47w	10	3	human	human	JJ
cord-000947-psguw47w	10	4	creatine	creatine	NN
cord-000947-psguw47w	10	5	kinase	kinase	NNS
cord-000947-psguw47w	10	6	were	be	VBD
cord-000947-psguw47w	10	7	predicted	predict	VBN
cord-000947-psguw47w	10	8	by	by	IN
cord-000947-psguw47w	10	9	computer	computer	NN
cord-000947-psguw47w	10	10	and	and	CC
cord-000947-psguw47w	10	11	then	then	RB
cord-000947-psguw47w	10	12	the	the	DT
cord-000947-psguw47w	10	13	binding	binding	NN
cord-000947-psguw47w	10	14	of	of	IN
cord-000947-psguw47w	10	15	scFv	scfv	JJ
cord-000947-psguw47w	10	16	-	-	HYPH
cord-000947-psguw47w	10	17	A4	A4	NNP
cord-000947-psguw47w	10	18	and	and	CC
cord-000947-psguw47w	10	19	HCK	HCK	NNP
cord-000947-psguw47w	10	20	was	be	VBD
cord-000947-psguw47w	10	21	modeled	model	VBN
cord-000947-psguw47w	10	22	with	with	IN
cord-000947-psguw47w	10	23	computer	computer	NN
cord-000947-psguw47w	10	24	.	.	.
cord-000947-psguw47w	11	1	The	the	DT
cord-000947-psguw47w	11	2	calculation	calculation	NN
cord-000947-psguw47w	11	3	results	result	NNS
cord-000947-psguw47w	11	4	were	be	VBD
cord-000947-psguw47w	11	5	further	further	RB
cord-000947-psguw47w	11	6	combined	combine	VBN
cord-000947-psguw47w	11	7	with	with	IN
cord-000947-psguw47w	11	8	the	the	DT
cord-000947-psguw47w	11	9	peptide	peptide	NN
cord-000947-psguw47w	11	10	array	array	NN
cord-000947-psguw47w	11	11	membrane	membrane	NN
cord-000947-psguw47w	11	12	experiment	experiment	NN
cord-000947-psguw47w	11	13	results	result	NNS
cord-000947-psguw47w	11	14	to	to	TO
cord-000947-psguw47w	11	15	obtain	obtain	VB
cord-000947-psguw47w	11	16	reliable	reliable	JJ
cord-000947-psguw47w	11	17	models	model	NNS
cord-000947-psguw47w	11	18	for	for	IN
cord-000947-psguw47w	11	19	the	the	DT
cord-000947-psguw47w	11	20	scFv	scFv	NNP
cord-000947-psguw47w	11	21	-	-	HYPH
cord-000947-psguw47w	11	22	A4-HCK	A4-HCK	NNP
cord-000947-psguw47w	11	23	complex	complex	NN
cord-000947-psguw47w	11	24	.	.	.
cord-000947-psguw47w	12	1	Based	base	VBN
cord-000947-psguw47w	12	2	on	on	IN
cord-000947-psguw47w	12	3	the	the	DT
cord-000947-psguw47w	12	4	above	above	JJ
cord-000947-psguw47w	12	5	study	study	NN
cord-000947-psguw47w	12	6	we	-PRON-	PRP
cord-000947-psguw47w	12	7	gave	give	VBD
cord-000947-psguw47w	12	8	an	an	DT
cord-000947-psguw47w	12	9	explanation	explanation	NN
cord-000947-psguw47w	12	10	about	about	IN
cord-000947-psguw47w	12	11	how	how	WRB
cord-000947-psguw47w	12	12	scFv	scFv	NNP
cord-000947-psguw47w	12	13	-	-	HYPH
cord-000947-psguw47w	12	14	A4	A4	NNP
cord-000947-psguw47w	12	15	could	could	MD
cord-000947-psguw47w	12	16	act	act	VB
cord-000947-psguw47w	12	17	as	as	IN
cord-000947-psguw47w	12	18	a	a	DT
cord-000947-psguw47w	12	19	macromolecular	macromolecular	JJ
cord-000947-psguw47w	12	20	chaperone	chaperone	NN
cord-000947-psguw47w	12	21	assisting	assist	VBG
cord-000947-psguw47w	12	22	the	the	DT
cord-000947-psguw47w	12	23	folding	folding	NN
cord-000947-psguw47w	12	24	of	of	IN
cord-000947-psguw47w	12	25	HCK	HCK	NNP
cord-000947-psguw47w	12	26	.	.	.
cord-000947-psguw47w	13	1	This	this	DT
cord-000947-psguw47w	13	2	study	study	NN
cord-000947-psguw47w	13	3	provides	provide	VBZ
cord-000947-psguw47w	13	4	an	an	DT
cord-000947-psguw47w	13	5	approach	approach	NN
cord-000947-psguw47w	13	6	for	for	IN
cord-000947-psguw47w	13	7	predicting	predict	VBG
cord-000947-psguw47w	13	8	antigen	antigen	NN
cord-000947-psguw47w	13	9	-	-	HYPH
cord-000947-psguw47w	13	10	antibody	antibody	NN
cord-000947-psguw47w	13	11	binding	binding	NN
cord-000947-psguw47w	13	12	mode	mode	NN
cord-000947-psguw47w	13	13	and	and	CC
cord-000947-psguw47w	13	14	also	also	RB
cord-000947-psguw47w	13	15	a	a	DT
cord-000947-psguw47w	13	16	useful	useful	JJ
cord-000947-psguw47w	13	17	theoretical	theoretical	JJ
cord-000947-psguw47w	13	18	guidance	guidance	NN
cord-000947-psguw47w	13	19	for	for	IN
cord-000947-psguw47w	13	20	the	the	DT
cord-000947-psguw47w	13	21	study	study	NN
cord-000947-psguw47w	13	22	of	of	IN
cord-000947-psguw47w	13	23	antibodies	antibody	NNS
cord-000947-psguw47w	13	24	'	'	POS
cord-000947-psguw47w	13	25	chaperone	chaperone	NN
cord-000947-psguw47w	13	26	-	-	HYPH
cord-000947-psguw47w	13	27	like	like	JJ
cord-000947-psguw47w	13	28	function	function	NN
cord-000947-psguw47w	13	29	.	.	.
cord-000947-psguw47w	14	1	In	in	IN
cord-000947-psguw47w	14	2	recent	recent	JJ
cord-000947-psguw47w	14	3	years	year	NNS
cord-000947-psguw47w	14	4	,	,	,
cord-000947-psguw47w	14	5	a	a	DT
cord-000947-psguw47w	14	6	number	number	NN
cord-000947-psguw47w	14	7	of	of	IN
cord-000947-psguw47w	14	8	human	human	JJ
cord-000947-psguw47w	14	9	diseases	disease	NNS
cord-000947-psguw47w	14	10	,	,	,
cord-000947-psguw47w	14	11	such	such	JJ
cord-000947-psguw47w	14	12	as	as	IN
cord-000947-psguw47w	14	13	Alzheimer	Alzheimer	NNP
cord-000947-psguw47w	14	14	's	's	POS
cord-000947-psguw47w	14	15	,	,	,
cord-000947-psguw47w	14	16	Huntington	Huntington	NNP
cord-000947-psguw47w	14	17	's	's	POS
cord-000947-psguw47w	14	18	,	,	,
cord-000947-psguw47w	14	19	Parkinson	Parkinson	NNP
cord-000947-psguw47w	14	20	's	's	POS
cord-000947-psguw47w	14	21	,	,	,
cord-000947-psguw47w	14	22	and	and	CC
cord-000947-psguw47w	14	23	Creutzfeldt	Creutzfeldt	NNP
cord-000947-psguw47w	14	24	-	-	HYPH
cord-000947-psguw47w	14	25	Jakob	Jakob	NNP
cord-000947-psguw47w	14	26	's	's	POS
cord-000947-psguw47w	14	27	diseases	disease	NNS
cord-000947-psguw47w	14	28	,	,	,
cord-000947-psguw47w	14	29	were	be	VBD
cord-000947-psguw47w	14	30	reported	report	VBN
cord-000947-psguw47w	14	31	to	to	TO
cord-000947-psguw47w	14	32	be	be	VB
cord-000947-psguw47w	14	33	related	relate	VBN
cord-000947-psguw47w	14	34	to	to	IN
cord-000947-psguw47w	14	35	the	the	DT
cord-000947-psguw47w	14	36	misfolding	misfolding	NN
cord-000947-psguw47w	14	37	and	and	CC
cord-000947-psguw47w	14	38	aggregation	aggregation	NN
cord-000947-psguw47w	14	39	of	of	IN
cord-000947-psguw47w	14	40	proteins	protein	NNS
cord-000947-psguw47w	14	41	[	[	-LRB-
cord-000947-psguw47w	14	42	1	1	CD
cord-000947-psguw47w	14	43	,	,	,
cord-000947-psguw47w	14	44	2	2	CD
cord-000947-psguw47w	14	45	]	]	-RRB-
cord-000947-psguw47w	14	46	.	.	.
cord-000947-psguw47w	15	1	Molecular	molecular	JJ
cord-000947-psguw47w	15	2	chaperones	chaperone	NNS
cord-000947-psguw47w	15	3	are	be	VBP
cord-000947-psguw47w	15	4	a	a	DT
cord-000947-psguw47w	15	5	kind	kind	NN
cord-000947-psguw47w	15	6	of	of	IN
cord-000947-psguw47w	15	7	protein	protein	NN
cord-000947-psguw47w	15	8	that	that	WDT
cord-000947-psguw47w	15	9	are	be	VBP
cord-000947-psguw47w	15	10	capable	capable	JJ
cord-000947-psguw47w	15	11	of	of	IN
cord-000947-psguw47w	15	12	assisting	assist	VBG
cord-000947-psguw47w	15	13	nascent	nascent	JJ
cord-000947-psguw47w	15	14	peptides	peptide	NNS
cord-000947-psguw47w	15	15	in	in	IN
cord-000947-psguw47w	15	16	correctly	correctly	RB
cord-000947-psguw47w	15	17	folding	fold	VBG
cord-000947-psguw47w	15	18	to	to	IN
cord-000947-psguw47w	15	19	functional	functional	JJ
cord-000947-psguw47w	15	20	proteins	protein	NNS
cord-000947-psguw47w	15	21	by	by	IN
cord-000947-psguw47w	15	22	binding	bind	VBG
cord-000947-psguw47w	15	23	to	to	IN
cord-000947-psguw47w	15	24	the	the	DT
cord-000947-psguw47w	15	25	folding	folding	NN
cord-000947-psguw47w	15	26	intermediate	intermediate	JJ
cord-000947-psguw47w	15	27	to	to	TO
cord-000947-psguw47w	15	28	avoid	avoid	VB
cord-000947-psguw47w	15	29	kinetic	kinetic	JJ
cord-000947-psguw47w	15	30	traps	trap	NNS
cord-000947-psguw47w	15	31	,	,	,
cord-000947-psguw47w	15	32	suppressing	suppress	VBG
cord-000947-psguw47w	15	33	aggregation	aggregation	NN
cord-000947-psguw47w	15	34	of	of	IN
cord-000947-psguw47w	15	35	the	the	DT
cord-000947-psguw47w	15	36	substrate	substrate	NN
cord-000947-psguw47w	15	37	[	[	-LRB-
cord-000947-psguw47w	15	38	3	3	CD
cord-000947-psguw47w	15	39	,	,	,
cord-000947-psguw47w	15	40	4	4	CD
cord-000947-psguw47w	15	41	]	]	-RRB-
cord-000947-psguw47w	15	42	.	.	.
cord-000947-psguw47w	16	1	Traditional	traditional	JJ
cord-000947-psguw47w	16	2	molecular	molecular	JJ
cord-000947-psguw47w	16	3	chaperones	chaperone	NNS
cord-000947-psguw47w	16	4	could	could	MD
cord-000947-psguw47w	16	5	be	be	VB
cord-000947-psguw47w	16	6	classified	classify	VBN
cord-000947-psguw47w	16	7	according	accord	VBG
cord-000947-psguw47w	16	8	to	to	IN
cord-000947-psguw47w	16	9	their	-PRON-	PRP$
cord-000947-psguw47w	16	10	molecular	molecular	JJ
cord-000947-psguw47w	16	11	weights	weight	NNS
cord-000947-psguw47w	16	12	and	and	CC
cord-000947-psguw47w	16	13	sequences	sequence	NNS
cord-000947-psguw47w	16	14	to	to	IN
cord-000947-psguw47w	16	15	families	family	NNS
cord-000947-psguw47w	16	16	such	such	JJ
cord-000947-psguw47w	16	17	as	as	IN
cord-000947-psguw47w	16	18	HSP90	HSP90	NNP
cord-000947-psguw47w	16	19	,	,	,
cord-000947-psguw47w	16	20	HSP70	HSP70	NNP
cord-000947-psguw47w	16	21	,	,	,
cord-000947-psguw47w	16	22	HSP60	HSP60	NNP
cord-000947-psguw47w	16	23	and	and	CC
cord-000947-psguw47w	16	24	nucleoplasmin	nucleoplasmin	NNP
cord-000947-psguw47w	16	25	.	.	.
cord-000947-psguw47w	17	1	They	-PRON-	PRP
cord-000947-psguw47w	17	2	have	have	VBP
cord-000947-psguw47w	17	3	low	low	JJ
cord-000947-psguw47w	17	4	specificity	specificity	NN
cord-000947-psguw47w	17	5	and	and	CC
cord-000947-psguw47w	17	6	react	react	VB
cord-000947-psguw47w	17	7	with	with	IN
cord-000947-psguw47w	17	8	many	many	JJ
cord-000947-psguw47w	17	9	kinds	kind	NNS
cord-000947-psguw47w	17	10	of	of	IN
cord-000947-psguw47w	17	11	proteins	protein	NNS
cord-000947-psguw47w	17	12	.	.	.
cord-000947-psguw47w	18	1	The	the	DT
cord-000947-psguw47w	18	2	low	low	JJ
cord-000947-psguw47w	18	3	specificity	specificity	NN
cord-000947-psguw47w	18	4	of	of	IN
cord-000947-psguw47w	18	5	conventional	conventional	JJ
cord-000947-psguw47w	18	6	molecular	molecular	JJ
cord-000947-psguw47w	18	7	chaperones	chaperone	NNS
cord-000947-psguw47w	18	8	enables	enable	VBZ
cord-000947-psguw47w	18	9	them	-PRON-	PRP
cord-000947-psguw47w	18	10	to	to	TO
cord-000947-psguw47w	18	11	help	help	VB
cord-000947-psguw47w	18	12	many	many	JJ
cord-000947-psguw47w	18	13	house	house	NN
cord-000947-psguw47w	18	14	-	-	HYPH
cord-000947-psguw47w	18	15	keeping	keep	VBG
cord-000947-psguw47w	18	16	proteins	protein	NNS
cord-000947-psguw47w	18	17	simultaneously	simultaneously	RB
cord-000947-psguw47w	18	18	.	.	.
cord-000947-psguw47w	19	1	But	but	CC
cord-000947-psguw47w	19	2	a	a	DT
cord-000947-psguw47w	19	3	protein	protein	NN
cord-000947-psguw47w	19	4	-	-	HYPH
cord-000947-psguw47w	19	5	misfolding	misfolde	VBG
cord-000947-psguw47w	19	6	disease	disease	NN
cord-000947-psguw47w	19	7	might	may	MD
cord-000947-psguw47w	19	8	be	be	VB
cord-000947-psguw47w	19	9	caused	cause	VBN
cord-000947-psguw47w	19	10	by	by	IN
cord-000947-psguw47w	19	11	only	only	RB
cord-000947-psguw47w	19	12	one	one	CD
cord-000947-psguw47w	19	13	specie	specie	NN
cord-000947-psguw47w	19	14	of	of	IN
cord-000947-psguw47w	19	15	protein	protein	NN
cord-000947-psguw47w	19	16	which	which	WDT
cord-000947-psguw47w	19	17	carries	carry	VBZ
cord-000947-psguw47w	19	18	point	point	NN
cord-000947-psguw47w	19	19	mutants	mutant	NNS
cord-000947-psguw47w	19	20	while	while	IN
cord-000947-psguw47w	19	21	most	most	JJS
cord-000947-psguw47w	19	22	other	other	JJ
cord-000947-psguw47w	19	23	housekeeping	housekeeping	NN
cord-000947-psguw47w	19	24	proteins	protein	NNS
cord-000947-psguw47w	19	25	are	be	VBP
cord-000947-psguw47w	19	26	normal	normal	JJ
cord-000947-psguw47w	19	27	[	[	-LRB-
cord-000947-psguw47w	19	28	5	5	CD
cord-000947-psguw47w	19	29	]	]	-RRB-
cord-000947-psguw47w	19	30	.	.	.
cord-000947-psguw47w	20	1	Thus	thus	RB
cord-000947-psguw47w	20	2	the	the	DT
cord-000947-psguw47w	20	3	use	use	NN
cord-000947-psguw47w	20	4	of	of	IN
cord-000947-psguw47w	20	5	traditional	traditional	JJ
cord-000947-psguw47w	20	6	molecular	molecular	JJ
cord-000947-psguw47w	20	7	chaperones	chaperone	NNS
cord-000947-psguw47w	20	8	as	as	IN
cord-000947-psguw47w	20	9	therapeutic	therapeutic	JJ
cord-000947-psguw47w	20	10	molecules	molecule	NNS
cord-000947-psguw47w	20	11	for	for	IN
cord-000947-psguw47w	20	12	misfolding	misfolde	VBG
cord-000947-psguw47w	20	13	diseases	disease	NNS
cord-000947-psguw47w	20	14	may	may	MD
cord-000947-psguw47w	20	15	have	have	VB
cord-000947-psguw47w	20	16	problems	problem	NNS
cord-000947-psguw47w	20	17	such	such	JJ
cord-000947-psguw47w	20	18	as	as	IN
cord-000947-psguw47w	20	19	low	low	JJ
cord-000947-psguw47w	20	20	efficiency	efficiency	NN
cord-000947-psguw47w	20	21	and	and	CC
cord-000947-psguw47w	20	22	undesired	undesired	JJ
cord-000947-psguw47w	20	23	side	side	NN
cord-000947-psguw47w	20	24	-	-	HYPH
cord-000947-psguw47w	20	25	effects	effect	NNS
cord-000947-psguw47w	20	26	.	.	.
cord-000947-psguw47w	21	1	A	a	DT
cord-000947-psguw47w	21	2	new	new	JJ
cord-000947-psguw47w	21	3	field	field	NN
cord-000947-psguw47w	21	4	in	in	IN
cord-000947-psguw47w	21	5	development	development	NN
cord-000947-psguw47w	21	6	is	be	VBZ
cord-000947-psguw47w	21	7	to	to	TO
cord-000947-psguw47w	21	8	design	design	VB
cord-000947-psguw47w	21	9	or	or	CC
cord-000947-psguw47w	21	10	screen	screen	VB
cord-000947-psguw47w	21	11	specific	specific	JJ
cord-000947-psguw47w	21	12	macromolecules	macromolecule	NNS
cord-000947-psguw47w	21	13	which	which	WDT
cord-000947-psguw47w	21	14	could	could	MD
cord-000947-psguw47w	21	15	be	be	VB
cord-000947-psguw47w	21	16	used	use	VBN
cord-000947-psguw47w	21	17	as	as	IN
cord-000947-psguw47w	21	18	chaperones	chaperone	NNS
cord-000947-psguw47w	21	19	for	for	IN
cord-000947-psguw47w	21	20	target	target	NN
cord-000947-psguw47w	21	21	proteins	protein	NNS
cord-000947-psguw47w	21	22	,	,	,
cord-000947-psguw47w	21	23	inhibiting	inhibit	VBG
cord-000947-psguw47w	21	24	their	-PRON-	PRP$
cord-000947-psguw47w	21	25	misfolding	misfolding	NN
cord-000947-psguw47w	21	26	or	or	CC
cord-000947-psguw47w	21	27	coagulation	coagulation	NN
cord-000947-psguw47w	21	28	to	to	TO
cord-000947-psguw47w	21	29	cure	cure	VB
cord-000947-psguw47w	21	30	the	the	DT
cord-000947-psguw47w	21	31	related	relate	VBN
cord-000947-psguw47w	21	32	protein	protein	NN
cord-000947-psguw47w	21	33	-	-	HYPH
cord-000947-psguw47w	21	34	misfolding	misfolde	VBG
cord-000947-psguw47w	21	35	diseases	disease	NNS
cord-000947-psguw47w	21	36	[	[	-LRB-
cord-000947-psguw47w	21	37	6	6	CD
cord-000947-psguw47w	21	38	]	]	-RRB-
cord-000947-psguw47w	21	39	[	[	-LRB-
cord-000947-psguw47w	21	40	7	7	CD
cord-000947-psguw47w	21	41	]	]	-RRB-
cord-000947-psguw47w	21	42	[	[	-LRB-
cord-000947-psguw47w	21	43	8	8	CD
cord-000947-psguw47w	21	44	]	]	-RRB-
cord-000947-psguw47w	21	45	.	.	.
cord-000947-psguw47w	22	1	Antibodies	antibody	NNS
cord-000947-psguw47w	22	2	are	be	VBP
cord-000947-psguw47w	22	3	the	the	DT
cord-000947-psguw47w	22	4	most	most	RBS
cord-000947-psguw47w	22	5	common	common	JJ
cord-000947-psguw47w	22	6	macromolecules	macromolecule	NNS
cord-000947-psguw47w	22	7	that	that	WDT
cord-000947-psguw47w	22	8	can	can	MD
cord-000947-psguw47w	22	9	bind	bind	VB
cord-000947-psguw47w	22	10	specifically	specifically	RB
cord-000947-psguw47w	22	11	to	to	TO
cord-000947-psguw47w	22	12	target	target	VB
cord-000947-psguw47w	22	13	proteins	protein	NNS
cord-000947-psguw47w	22	14	.	.	.
cord-000947-psguw47w	23	1	Previous	previous	JJ
cord-000947-psguw47w	23	2	researches	research	NNS
cord-000947-psguw47w	23	3	had	have	VBD
cord-000947-psguw47w	23	4	shown	show	VBN
cord-000947-psguw47w	23	5	that	that	IN
cord-000947-psguw47w	23	6	some	some	DT
cord-000947-psguw47w	23	7	antibodies	antibody	NNS
cord-000947-psguw47w	23	8	could	could	MD
cord-000947-psguw47w	23	9	excert	excert	VB
cord-000947-psguw47w	23	10	a	a	DT
cord-000947-psguw47w	23	11	chaperone	chaperone	NN
cord-000947-psguw47w	23	12	-	-	HYPH
cord-000947-psguw47w	23	13	like	like	JJ
cord-000947-psguw47w	23	14	function	function	NN
cord-000947-psguw47w	23	15	on	on	IN
cord-000947-psguw47w	23	16	their	-PRON-	PRP$
cord-000947-psguw47w	23	17	antigens	antigen	NNS
cord-000947-psguw47w	23	18	[	[	-LRB-
cord-000947-psguw47w	23	19	9	9	CD
cord-000947-psguw47w	23	20	]	]	-RRB-
cord-000947-psguw47w	23	21	.	.	.
cord-000947-psguw47w	24	1	Therefore	therefore	RB
cord-000947-psguw47w	24	2	antibodies	antibody	NNS
cord-000947-psguw47w	24	3	with	with	IN
cord-000947-psguw47w	24	4	a	a	DT
cord-000947-psguw47w	24	5	chaperone	chaperone	NN
cord-000947-psguw47w	24	6	-	-	HYPH
cord-000947-psguw47w	24	7	like	like	JJ
cord-000947-psguw47w	24	8	function	function	NN
cord-000947-psguw47w	24	9	were	be	VBD
cord-000947-psguw47w	24	10	considered	consider	VBN
cord-000947-psguw47w	24	11	as	as	IN
cord-000947-psguw47w	24	12	the	the	DT
cord-000947-psguw47w	24	13	therapeutic	therapeutic	JJ
cord-000947-psguw47w	24	14	drug	drug	NN
cord-000947-psguw47w	24	15	candidates	candidate	NNS
cord-000947-psguw47w	24	16	for	for	IN
cord-000947-psguw47w	24	17	protein	protein	NN
cord-000947-psguw47w	24	18	misfolding	misfolde	VBG
cord-000947-psguw47w	24	19	diseases	disease	NNS
cord-000947-psguw47w	24	20	because	because	IN
cord-000947-psguw47w	24	21	they	-PRON-	PRP
cord-000947-psguw47w	24	22	only	only	RB
cord-000947-psguw47w	24	23	affect	affect	VBP
cord-000947-psguw47w	24	24	mutant	mutant	JJ
cord-000947-psguw47w	24	25	proteins	protein	NNS
cord-000947-psguw47w	24	26	,	,	,
cord-000947-psguw47w	24	27	leaving	leave	VBG
cord-000947-psguw47w	24	28	normal	normal	JJ
cord-000947-psguw47w	24	29	proteins	protein	NNS
cord-000947-psguw47w	24	30	intact	intact	JJ
cord-000947-psguw47w	24	31	.	.	.
cord-000947-psguw47w	25	1	In	in	IN
cord-000947-psguw47w	25	2	addition	addition	NN
cord-000947-psguw47w	25	3	,	,	,
cord-000947-psguw47w	25	4	antibodies	antibody	NNS
cord-000947-psguw47w	25	5	with	with	IN
cord-000947-psguw47w	25	6	a	a	DT
cord-000947-psguw47w	25	7	chaperone	chaperone	NN
cord-000947-psguw47w	25	8	-	-	HYPH
cord-000947-psguw47w	25	9	like	like	JJ
cord-000947-psguw47w	25	10	function	function	NN
cord-000947-psguw47w	25	11	were	be	VBD
cord-000947-psguw47w	25	12	helpful	helpful	JJ
cord-000947-psguw47w	25	13	research	research	NN
cord-000947-psguw47w	25	14	tools	tool	NNS
cord-000947-psguw47w	25	15	for	for	IN
cord-000947-psguw47w	25	16	protein	protein	NN
cord-000947-psguw47w	25	17	folding	folding	NN
cord-000947-psguw47w	25	18	researches	research	NNS
cord-000947-psguw47w	25	19	.	.	.
cord-000947-psguw47w	26	1	Human	human	JJ
cord-000947-psguw47w	26	2	creatine	creatine	NN
cord-000947-psguw47w	26	3	kinase	kinase	NN
cord-000947-psguw47w	26	4	(	(	-LRB-
cord-000947-psguw47w	26	5	HCK	HCK	NNP
cord-000947-psguw47w	26	6	)	)	-RRB-
cord-000947-psguw47w	26	7	is	be	VBZ
cord-000947-psguw47w	26	8	a	a	DT
cord-000947-psguw47w	26	9	protein	protein	NN
cord-000947-psguw47w	26	10	of	of	IN
cord-000947-psguw47w	26	11	important	important	JJ
cord-000947-psguw47w	26	12	physiological	physiological	JJ
cord-000947-psguw47w	26	13	function	function	NN
cord-000947-psguw47w	26	14	,	,	,
cord-000947-psguw47w	26	15	which	which	WDT
cord-000947-psguw47w	26	16	is	be	VBZ
cord-000947-psguw47w	26	17	closely	closely	RB
cord-000947-psguw47w	26	18	related	related	JJ
cord-000947-psguw47w	26	19	to	to	IN
cord-000947-psguw47w	26	20	intracellular	intracellular	JJ
cord-000947-psguw47w	26	21	energy	energy	NN
cord-000947-psguw47w	26	22	operation	operation	NN
cord-000947-psguw47w	26	23	,	,	,
cord-000947-psguw47w	26	24	muscle	muscle	NN
cord-000947-psguw47w	26	25	contraction	contraction	NN
cord-000947-psguw47w	26	26	and	and	CC
cord-000947-psguw47w	26	27	ATP	ATP	NNP
cord-000947-psguw47w	26	28	regeneration	regeneration	NN
cord-000947-psguw47w	26	29	[	[	-LRB-
cord-000947-psguw47w	26	30	10	10	CD
cord-000947-psguw47w	26	31	]	]	-RRB-
cord-000947-psguw47w	26	32	.	.	.
cord-000947-psguw47w	27	1	According	accord	VBG
cord-000947-psguw47w	27	2	to	to	IN
cord-000947-psguw47w	27	3	existing	exist	VBG
cord-000947-psguw47w	27	4	researches	research	NNS
cord-000947-psguw47w	27	5	in	in	IN
cord-000947-psguw47w	27	6	the	the	DT
cord-000947-psguw47w	27	7	folding	folding	NN
cord-000947-psguw47w	27	8	of	of	IN
cord-000947-psguw47w	27	9	HCK	HCK	NNP
cord-000947-psguw47w	27	10	,	,	,
cord-000947-psguw47w	27	11	the	the	DT
cord-000947-psguw47w	27	12	dysfunction	dysfunction	NN
cord-000947-psguw47w	27	13	of	of	IN
cord-000947-psguw47w	27	14	HCK	HCK	NNP
cord-000947-psguw47w	27	15	could	could	MD
cord-000947-psguw47w	27	16	be	be	VB
cord-000947-psguw47w	27	17	a	a	DT
cord-000947-psguw47w	27	18	highly	highly	RB
cord-000947-psguw47w	27	19	possible	possible	JJ
cord-000947-psguw47w	27	20	pathogenic	pathogenic	JJ
cord-000947-psguw47w	27	21	factor	factor	NN
cord-000947-psguw47w	27	22	of	of	IN
cord-000947-psguw47w	27	23	many	many	JJ
cord-000947-psguw47w	27	24	serious	serious	JJ
cord-000947-psguw47w	27	25	diseases	disease	NNS
cord-000947-psguw47w	27	26	[	[	-LRB-
cord-000947-psguw47w	27	27	11	11	CD
cord-000947-psguw47w	27	28	,	,	,
cord-000947-psguw47w	27	29	12	12	CD
cord-000947-psguw47w	27	30	]	]	-RRB-
cord-000947-psguw47w	27	31	.	.	.
cord-000947-psguw47w	28	1	Our	-PRON-	PRP$
cord-000947-psguw47w	28	2	previous	previous	JJ
cord-000947-psguw47w	28	3	studies	study	NNS
cord-000947-psguw47w	28	4	[	[	-LRB-
cord-000947-psguw47w	28	5	13	13	CD
cord-000947-psguw47w	28	6	]	]	-RRB-
cord-000947-psguw47w	28	7	indicate	indicate	VBP
cord-000947-psguw47w	28	8	that	that	IN
cord-000947-psguw47w	28	9	HCK	HCK	NNP
cord-000947-psguw47w	28	10	expressed	express	VBD
cord-000947-psguw47w	28	11	in	in	IN
cord-000947-psguw47w	28	12	E.	E.	NNP
cord-000947-psguw47w	28	13	coli	coli	NNS
cord-000947-psguw47w	28	14	existed	exist	VBD
cord-000947-psguw47w	28	15	as	as	IN
cord-000947-psguw47w	28	16	inclusion	inclusion	NN
cord-000947-psguw47w	28	17	bodies	body	NNS
cord-000947-psguw47w	28	18	.	.	.
cord-000947-psguw47w	29	1	Antibodies	antibody	NNS
cord-000947-psguw47w	29	2	produced	produce	VBN
cord-000947-psguw47w	29	3	by	by	IN
cord-000947-psguw47w	29	4	using	use	VBG
cord-000947-psguw47w	29	5	HCK	HCK	NNP
cord-000947-psguw47w	29	6	expressed	express	VBN
cord-000947-psguw47w	29	7	by	by	IN
cord-000947-psguw47w	29	8	E.	E.	NNP
cord-000947-psguw47w	29	9	coli	coli	NNS
cord-000947-psguw47w	29	10	as	as	IN
cord-000947-psguw47w	29	11	antigen	antigen	NN
cord-000947-psguw47w	29	12	could	could	MD
cord-000947-psguw47w	29	13	be	be	VB
cord-000947-psguw47w	29	14	used	use	VBN
cord-000947-psguw47w	29	15	to	to	TO
cord-000947-psguw47w	29	16	study	study	VB
cord-000947-psguw47w	29	17	the	the	DT
cord-000947-psguw47w	29	18	renaturation	renaturation	NN
cord-000947-psguw47w	29	19	of	of	IN
cord-000947-psguw47w	29	20	inclusion	inclusion	NN
cord-000947-psguw47w	29	21	bodies	body	NNS
cord-000947-psguw47w	29	22	,	,	,
cord-000947-psguw47w	29	23	such	such	JJ
cord-000947-psguw47w	29	24	as	as	IN
cord-000947-psguw47w	29	25	capturing	capture	VBG
cord-000947-psguw47w	29	26	the	the	DT
cord-000947-psguw47w	29	27	intermediates	intermediate	NNS
cord-000947-psguw47w	29	28	during	during	IN
cord-000947-psguw47w	29	29	the	the	DT
cord-000947-psguw47w	29	30	folding	folding	NN
cord-000947-psguw47w	29	31	process	process	NN
cord-000947-psguw47w	29	32	of	of	IN
cord-000947-psguw47w	29	33	HCK	HCK	NNP
cord-000947-psguw47w	29	34	to	to	TO
cord-000947-psguw47w	29	35	study	study	VB
cord-000947-psguw47w	29	36	the	the	DT
cord-000947-psguw47w	29	37	structural	structural	JJ
cord-000947-psguw47w	29	38	characteristics	characteristic	NNS
cord-000947-psguw47w	29	39	of	of	IN
cord-000947-psguw47w	29	40	the	the	DT
cord-000947-psguw47w	29	41	intermediates	intermediate	NNS
cord-000947-psguw47w	29	42	.	.	.
cord-000947-psguw47w	30	1	An	an	DT
cord-000947-psguw47w	30	2	scFv	scfv	NN
cord-000947-psguw47w	30	3	is	be	VBZ
cord-000947-psguw47w	30	4	a	a	DT
cord-000947-psguw47w	30	5	fragment	fragment	NN
cord-000947-psguw47w	30	6	of	of	IN
cord-000947-psguw47w	30	7	a	a	DT
cord-000947-psguw47w	30	8	conventional	conventional	JJ
cord-000947-psguw47w	30	9	antibody	antibody	NN
cord-000947-psguw47w	30	10	which	which	WDT
cord-000947-psguw47w	30	11	is	be	VBZ
cord-000947-psguw47w	30	12	constructed	construct	VBN
cord-000947-psguw47w	30	13	by	by	IN
cord-000947-psguw47w	30	14	connecting	connect	VBG
cord-000947-psguw47w	30	15	the	the	DT
cord-000947-psguw47w	30	16	variable	variable	JJ
cord-000947-psguw47w	30	17	domains	domain	NNS
cord-000947-psguw47w	30	18	of	of	IN
cord-000947-psguw47w	30	19	the	the	DT
cord-000947-psguw47w	30	20	antibody	antibody	NN
cord-000947-psguw47w	30	21	heavy	heavy	JJ
cord-000947-psguw47w	30	22	chain	chain	NN
cord-000947-psguw47w	30	23	and	and	CC
cord-000947-psguw47w	30	24	the	the	DT
cord-000947-psguw47w	30	25	light	light	JJ
cord-000947-psguw47w	30	26	chain	chain	NN
cord-000947-psguw47w	30	27	by	by	IN
cord-000947-psguw47w	30	28	a	a	DT
cord-000947-psguw47w	30	29	segment	segment	NN
cord-000947-psguw47w	30	30	of	of	IN
cord-000947-psguw47w	30	31	linker	linker	NN
cord-000947-psguw47w	30	32	peptide	peptide	NN
cord-000947-psguw47w	30	33	.	.	.
cord-000947-psguw47w	31	1	ScFvs	ScFvs	NNP
cord-000947-psguw47w	31	2	with	with	IN
cord-000947-psguw47w	31	3	high	high	JJ
cord-000947-psguw47w	31	4	affinity	affinity	NN
cord-000947-psguw47w	31	5	and	and	CC
cord-000947-psguw47w	31	6	specificity	specificity	NN
cord-000947-psguw47w	31	7	to	to	IN
cord-000947-psguw47w	31	8	their	-PRON-	PRP$
cord-000947-psguw47w	31	9	antigens	antigen	NNS
cord-000947-psguw47w	31	10	had	have	VBD
cord-000947-psguw47w	31	11	been	be	VBN
cord-000947-psguw47w	31	12	isolated	isolate	VBN
cord-000947-psguw47w	31	13	from	from	IN
cord-000947-psguw47w	31	14	phage	phage	NN
cord-000947-psguw47w	31	15	display	display	NN
cord-000947-psguw47w	31	16	libraries	library	NNS
cord-000947-psguw47w	31	17	by	by	IN
cord-000947-psguw47w	31	18	many	many	JJ
cord-000947-psguw47w	31	19	groups	group	NNS
cord-000947-psguw47w	31	20	[	[	-LRB-
cord-000947-psguw47w	31	21	14	14	CD
cord-000947-psguw47w	31	22	]	]	-RRB-
cord-000947-psguw47w	31	23	[	[	-LRB-
cord-000947-psguw47w	31	24	15	15	CD
cord-000947-psguw47w	31	25	]	]	-RRB-
cord-000947-psguw47w	31	26	[	[	-LRB-
cord-000947-psguw47w	31	27	16	16	CD
cord-000947-psguw47w	31	28	]	]	-RRB-
cord-000947-psguw47w	31	29	[	[	-LRB-
cord-000947-psguw47w	31	30	17	17	CD
cord-000947-psguw47w	31	31	]	]	-RRB-
cord-000947-psguw47w	31	32	.	.	.
cord-000947-psguw47w	32	1	Schlattner	Schlattner	NNP
cord-000947-psguw47w	32	2	[	[	-LRB-
cord-000947-psguw47w	32	3	18	18	CD
cord-000947-psguw47w	32	4	]	]	-RRB-
cord-000947-psguw47w	32	5	have	have	VBP
cord-000947-psguw47w	32	6	successfully	successfully	RB
cord-000947-psguw47w	32	7	isolated	isolate	VBN
cord-000947-psguw47w	32	8	several	several	JJ
cord-000947-psguw47w	32	9	scFv	scFv	HYPH
cord-000947-psguw47w	32	10	clones	clone	NNS
cord-000947-psguw47w	32	11	from	from	IN
cord-000947-psguw47w	32	12	a	a	DT
cord-000947-psguw47w	32	13	human	human	JJ
cord-000947-psguw47w	32	14	antibody	antibody	NN
cord-000947-psguw47w	32	15	phage	phage	NN
cord-000947-psguw47w	32	16	display	display	NN
cord-000947-psguw47w	32	17	library	library	NN
cord-000947-psguw47w	32	18	that	that	WDT
cord-000947-psguw47w	32	19	recognize	recognize	VBP
cord-000947-psguw47w	32	20	cytosolic	cytosolic	JJ
cord-000947-psguw47w	32	21	BB	BB	NNP
cord-000947-psguw47w	32	22	-	-	HYPH
cord-000947-psguw47w	32	23	CK	CK	NNP
cord-000947-psguw47w	32	24	.	.	.
cord-000947-psguw47w	33	1	In	in	IN
cord-000947-psguw47w	33	2	our	-PRON-	PRP$
cord-000947-psguw47w	33	3	previous	previous	JJ
cord-000947-psguw47w	33	4	work	work	NN
cord-000947-psguw47w	33	5	[	[	-LRB-
cord-000947-psguw47w	33	6	13	13	CD
cord-000947-psguw47w	33	7	]	]	-RRB-
cord-000947-psguw47w	33	8	several	several	JJ
cord-000947-psguw47w	33	9	scFvs	scFvs	NNP
cord-000947-psguw47w	33	10	had	have	VBD
cord-000947-psguw47w	33	11	been	be	VBN
cord-000947-psguw47w	33	12	screened	screen	VBN
cord-000947-psguw47w	33	13	out	out	RP
cord-000947-psguw47w	33	14	from	from	IN
cord-000947-psguw47w	33	15	a	a	DT
cord-000947-psguw47w	33	16	phage	phage	NN
cord-000947-psguw47w	33	17	library	library	NN
cord-000947-psguw47w	33	18	using	use	VBG
cord-000947-psguw47w	33	19	recombinational	recombinational	NNP
cord-000947-psguw47w	33	20	HCK	HCK	NNP
cord-000947-psguw47w	33	21	as	as	IN
cord-000947-psguw47w	33	22	antigen	antigen	NN
cord-000947-psguw47w	33	23	.	.	.
cord-000947-psguw47w	34	1	Only	only	RB
cord-000947-psguw47w	34	2	one	one	CD
cord-000947-psguw47w	34	3	of	of	IN
cord-000947-psguw47w	34	4	the	the	DT
cord-000947-psguw47w	34	5	scFvs	scFvs	NNP
cord-000947-psguw47w	34	6	named	name	VBN
cord-000947-psguw47w	34	7	scFv	scFv	NNP
cord-000947-psguw47w	34	8	-	-	HYPH
cord-000947-psguw47w	34	9	A4	A4	NNP
cord-000947-psguw47w	34	10	has	have	VBZ
cord-000947-psguw47w	34	11	a	a	DT
cord-000947-psguw47w	34	12	significant	significant	JJ
cord-000947-psguw47w	34	13	chaperonelike	chaperonelike	NN
cord-000947-psguw47w	34	14	function	function	NN
cord-000947-psguw47w	34	15	,	,	,
cord-000947-psguw47w	34	16	preventing	prevent	VBG
cord-000947-psguw47w	34	17	the	the	DT
cord-000947-psguw47w	34	18	aggregational	aggregational	JJ
cord-000947-psguw47w	34	19	precipitation	precipitation	NN
cord-000947-psguw47w	34	20	of	of	IN
cord-000947-psguw47w	34	21	HCK	HCK	NNP
cord-000947-psguw47w	34	22	during	during	IN
cord-000947-psguw47w	34	23	its	-PRON-	PRP$
cord-000947-psguw47w	34	24	folding	folding	NN
cord-000947-psguw47w	34	25	and	and	CC
cord-000947-psguw47w	34	26	accelerating	accelerate	VBG
cord-000947-psguw47w	34	27	its	-PRON-	PRP$
cord-000947-psguw47w	34	28	recovery	recovery	NN
cord-000947-psguw47w	34	29	to	to	IN
cord-000947-psguw47w	34	30	nature	nature	NN
cord-000947-psguw47w	34	31	conformation	conformation	NN
cord-000947-psguw47w	34	32	.	.	.
cord-000947-psguw47w	35	1	In	in	IN
cord-000947-psguw47w	35	2	order	order	NN
cord-000947-psguw47w	35	3	to	to	TO
cord-000947-psguw47w	35	4	comprehend	comprehend	VB
cord-000947-psguw47w	35	5	the	the	DT
cord-000947-psguw47w	35	6	unique	unique	JJ
cord-000947-psguw47w	35	7	chaperone	chaperone	NN
cord-000947-psguw47w	35	8	property	property	NN
cord-000947-psguw47w	35	9	of	of	IN
cord-000947-psguw47w	35	10	scFv	scFv	NNP
cord-000947-psguw47w	35	11	-	-	HYPH
cord-000947-psguw47w	35	12	A4	A4	NNP
cord-000947-psguw47w	35	13	,	,	,
cord-000947-psguw47w	35	14	the	the	DT
cord-000947-psguw47w	35	15	binding	binding	NN
cord-000947-psguw47w	35	16	between	between	IN
cord-000947-psguw47w	35	17	scFv	scFv	NNP
cord-000947-psguw47w	35	18	-	-	HYPH
cord-000947-psguw47w	35	19	A4	A4	NNP
cord-000947-psguw47w	35	20	and	and	CC
cord-000947-psguw47w	35	21	HCK	HCK	NNP
cord-000947-psguw47w	35	22	must	must	MD
cord-000947-psguw47w	35	23	be	be	VB
cord-000947-psguw47w	35	24	analyzed	analyze	VBN
cord-000947-psguw47w	35	25	.	.	.
cord-000947-psguw47w	36	1	The	the	DT
cord-000947-psguw47w	36	2	top	top	JJ
cord-000947-psguw47w	36	3	priority	priority	NN
cord-000947-psguw47w	36	4	would	would	MD
cord-000947-psguw47w	36	5	be	be	VB
cord-000947-psguw47w	36	6	identifying	identify	VBG
cord-000947-psguw47w	36	7	the	the	DT
cord-000947-psguw47w	36	8	portion	portion	NN
cord-000947-psguw47w	36	9	of	of	IN
cord-000947-psguw47w	36	10	HCK	HCK	NNP
cord-000947-psguw47w	36	11	bound	bind	VBN
cord-000947-psguw47w	36	12	by	by	IN
cord-000947-psguw47w	36	13	scFv	scFv	NNP
cord-000947-psguw47w	36	14	-	-	HYPH
cord-000947-psguw47w	36	15	A4	a4	NN
cord-000947-psguw47w	36	16	.	.	.
cord-000947-psguw47w	37	1	Molecular	molecular	JJ
cord-000947-psguw47w	37	2	docking	docking	NN
cord-000947-psguw47w	37	3	by	by	IN
cord-000947-psguw47w	37	4	computer	computer	NN
cord-000947-psguw47w	37	5	has	have	VBZ
cord-000947-psguw47w	37	6	been	be	VBN
cord-000947-psguw47w	37	7	widely	widely	RB
cord-000947-psguw47w	37	8	used	use	VBN
cord-000947-psguw47w	37	9	in	in	IN
cord-000947-psguw47w	37	10	the	the	DT
cord-000947-psguw47w	37	11	study	study	NN
cord-000947-psguw47w	37	12	of	of	IN
cord-000947-psguw47w	37	13	the	the	DT
cord-000947-psguw47w	37	14	binding	binding	JJ
cord-000947-psguw47w	37	15	mechanism	mechanism	NN
cord-000947-psguw47w	37	16	of	of	IN
cord-000947-psguw47w	37	17	protein	protein	NN
cord-000947-psguw47w	37	18	-	-	HYPH
cord-000947-psguw47w	37	19	protein	protein	NN
cord-000947-psguw47w	37	20	or	or	CC
cord-000947-psguw47w	37	21	proteinligand	proteinligand	NNP
cord-000947-psguw47w	37	22	systems	system	NNS
cord-000947-psguw47w	37	23	,	,	,
cord-000947-psguw47w	37	24	including	include	VBG
cord-000947-psguw47w	37	25	themes	theme	NNS
cord-000947-psguw47w	37	26	such	such	JJ
cord-000947-psguw47w	37	27	as	as	IN
cord-000947-psguw47w	37	28	protein	protein	NN
cord-000947-psguw47w	37	29	-	-	HYPH
cord-000947-psguw47w	37	30	folding	fold	VBG
cord-000947-psguw47w	37	31	mechanism	mechanism	NN
cord-000947-psguw47w	37	32	[	[	-LRB-
cord-000947-psguw47w	37	33	19	19	CD
cord-000947-psguw47w	37	34	,	,	,
cord-000947-psguw47w	37	35	20	20	CD
cord-000947-psguw47w	37	36	]	]	-RRB-
cord-000947-psguw47w	37	37	,	,	,
cord-000947-psguw47w	37	38	protein	protein	NN
cord-000947-psguw47w	37	39	-	-	HYPH
cord-000947-psguw47w	37	40	protein	protein	NN
cord-000947-psguw47w	37	41	surface	surface	NN
cord-000947-psguw47w	37	42	modification	modification	NN
cord-000947-psguw47w	37	43	[	[	-LRB-
cord-000947-psguw47w	37	44	21	21	CD
cord-000947-psguw47w	37	45	,	,	,
cord-000947-psguw47w	37	46	22	22	CD
cord-000947-psguw47w	37	47	]	]	-RRB-
cord-000947-psguw47w	37	48	,	,	,
cord-000947-psguw47w	37	49	improving	improve	VBG
cord-000947-psguw47w	37	50	the	the	DT
cord-000947-psguw47w	37	51	binding	binding	NN
cord-000947-psguw47w	37	52	between	between	IN
cord-000947-psguw47w	37	53	proteins	protein	NNS
cord-000947-psguw47w	37	54	and	and	CC
cord-000947-psguw47w	37	55	polypeptides	polypeptide	NNS
cord-000947-psguw47w	37	56	or	or	CC
cord-000947-psguw47w	37	57	small	small	JJ
cord-000947-psguw47w	37	58	molecules	molecule	NNS
cord-000947-psguw47w	37	59	[	[	-LRB-
cord-000947-psguw47w	37	60	23	23	CD
cord-000947-psguw47w	37	61	]	]	-RRB-
cord-000947-psguw47w	38	1	[	[	-LRB-
cord-000947-psguw47w	38	2	24	24	CD
cord-000947-psguw47w	38	3	]	]	-RRB-
cord-000947-psguw47w	38	4	[	[	-LRB-
cord-000947-psguw47w	38	5	25	25	CD
cord-000947-psguw47w	38	6	]	]	-RRB-
cord-000947-psguw47w	38	7	.	.	.
cord-000947-psguw47w	39	1	The	the	DT
cord-000947-psguw47w	39	2	number	number	NN
cord-000947-psguw47w	39	3	of	of	IN
cord-000947-psguw47w	39	4	degrees	degree	NNS
cord-000947-psguw47w	39	5	of	of	IN
cord-000947-psguw47w	39	6	freedom	freedom	NN
cord-000947-psguw47w	39	7	of	of	IN
cord-000947-psguw47w	39	8	protein	protein	NN
cord-000947-psguw47w	39	9	-	-	HYPH
cord-000947-psguw47w	39	10	protein	protein	NN
cord-000947-psguw47w	39	11	interactions	interaction	NNS
cord-000947-psguw47w	39	12	was	be	VBD
cord-000947-psguw47w	39	13	so	so	RB
cord-000947-psguw47w	39	14	large	large	JJ
cord-000947-psguw47w	39	15	that	that	IN
cord-000947-psguw47w	39	16	no	no	DT
cord-000947-psguw47w	39	17	docking	docking	NN
cord-000947-psguw47w	39	18	program	program	NN
cord-000947-psguw47w	39	19	nowadays	nowadays	RB
cord-000947-psguw47w	39	20	can	can	MD
cord-000947-psguw47w	39	21	search	search	VB
cord-000947-psguw47w	39	22	the	the	DT
cord-000947-psguw47w	39	23	conformational	conformational	JJ
cord-000947-psguw47w	39	24	space	space	NN
cord-000947-psguw47w	39	25	thoroughly	thoroughly	RB
cord-000947-psguw47w	39	26	even	even	RB
cord-000947-psguw47w	39	27	at	at	IN
cord-000947-psguw47w	39	28	the	the	DT
cord-000947-psguw47w	39	29	classical	classical	JJ
cord-000947-psguw47w	39	30	mechanics	mechanic	NNS
cord-000947-psguw47w	39	31	level	level	NN
cord-000947-psguw47w	39	32	of	of	IN
cord-000947-psguw47w	39	33	theory	theory	NN
cord-000947-psguw47w	39	34	.	.	.
cord-000947-psguw47w	40	1	Therefore	therefore	RB
cord-000947-psguw47w	40	2	,	,	,
cord-000947-psguw47w	40	3	no	no	DT
cord-000947-psguw47w	40	4	current	current	JJ
cord-000947-psguw47w	40	5	software	software	NN
cord-000947-psguw47w	40	6	is	be	VBZ
cord-000947-psguw47w	40	7	able	able	JJ
cord-000947-psguw47w	40	8	to	to	TO
cord-000947-psguw47w	40	9	correctly	correctly	RB
cord-000947-psguw47w	40	10	dock	dock	VB
cord-000947-psguw47w	40	11	two	two	CD
cord-000947-psguw47w	40	12	proteins	protein	NNS
cord-000947-psguw47w	40	13	ab	ab	NN
cord-000947-psguw47w	40	14	initio	initio	NNP
cord-000947-psguw47w	40	15	.	.	.
cord-000947-psguw47w	41	1	One	one	CD
cord-000947-psguw47w	41	2	approach	approach	NN
cord-000947-psguw47w	41	3	to	to	TO
cord-000947-psguw47w	41	4	reduce	reduce	VB
cord-000947-psguw47w	41	5	the	the	DT
cord-000947-psguw47w	41	6	search	search	NN
cord-000947-psguw47w	41	7	space	space	NN
cord-000947-psguw47w	41	8	for	for	IN
cord-000947-psguw47w	41	9	protein	protein	NN
cord-000947-psguw47w	41	10	-	-	HYPH
cord-000947-psguw47w	41	11	protein	protein	NN
cord-000947-psguw47w	41	12	interactions	interaction	NNS
cord-000947-psguw47w	41	13	is	be	VBZ
cord-000947-psguw47w	41	14	to	to	TO
cord-000947-psguw47w	41	15	predict	predict	VB
cord-000947-psguw47w	41	16	protein	protein	NN
cord-000947-psguw47w	41	17	-	-	HYPH
cord-000947-psguw47w	41	18	protein	protein	NN
cord-000947-psguw47w	41	19	interaction	interaction	NN
cord-000947-psguw47w	41	20	sites	site	NNS
cord-000947-psguw47w	41	21	first	first	RB
cord-000947-psguw47w	41	22	and	and	CC
cord-000947-psguw47w	41	23	then	then	RB
cord-000947-psguw47w	41	24	use	use	VB
cord-000947-psguw47w	41	25	the	the	DT
cord-000947-psguw47w	41	26	orientational	orientational	JJ
cord-000947-psguw47w	41	27	docking	docking	NN
cord-000947-psguw47w	41	28	method	method	NN
cord-000947-psguw47w	41	29	to	to	TO
cord-000947-psguw47w	41	30	test	test	VB
cord-000947-psguw47w	41	31	the	the	DT
cord-000947-psguw47w	41	32	possibility	possibility	NN
cord-000947-psguw47w	41	33	of	of	IN
cord-000947-psguw47w	41	34	the	the	DT
cord-000947-psguw47w	41	35	binding	binding	NN
cord-000947-psguw47w	41	36	.	.	.
cord-000947-psguw47w	42	1	This	this	DT
cord-000947-psguw47w	42	2	is	be	VBZ
cord-000947-psguw47w	42	3	the	the	DT
cord-000947-psguw47w	42	4	approach	approach	NN
cord-000947-psguw47w	42	5	used	use	VBN
cord-000947-psguw47w	42	6	in	in	IN
cord-000947-psguw47w	42	7	this	this	DT
cord-000947-psguw47w	42	8	work	work	NN
cord-000947-psguw47w	42	9	.	.	.
cord-000947-psguw47w	43	1	As	as	IN
cord-000947-psguw47w	43	2	to	to	IN
cord-000947-psguw47w	43	3	antigen	antigen	NN
cord-000947-psguw47w	43	4	-	-	HYPH
cord-000947-psguw47w	43	5	antibody	antibody	NN
cord-000947-psguw47w	43	6	binding	binding	NN
cord-000947-psguw47w	43	7	,	,	,
cord-000947-psguw47w	43	8	the	the	DT
cord-000947-psguw47w	43	9	parts	part	NNS
cord-000947-psguw47w	43	10	of	of	IN
cord-000947-psguw47w	43	11	the	the	DT
cord-000947-psguw47w	43	12	antibodies	antibody	NNS
cord-000947-psguw47w	43	13	bound	bind	VBN
cord-000947-psguw47w	43	14	to	to	IN
cord-000947-psguw47w	43	15	antigens	antigen	NNS
cord-000947-psguw47w	43	16	were	be	VBD
cord-000947-psguw47w	43	17	defined	define	VBN
cord-000947-psguw47w	43	18	as	as	IN
cord-000947-psguw47w	43	19	CDR	cdr	NN
cord-000947-psguw47w	43	20	regions	region	NNS
cord-000947-psguw47w	43	21	(	(	-LRB-
cord-000947-psguw47w	43	22	complementarity	complementarity	NN
cord-000947-psguw47w	43	23	determining	determine	VBG
cord-000947-psguw47w	43	24	regions	region	NNS
cord-000947-psguw47w	43	25	)	)	-RRB-
cord-000947-psguw47w	43	26	which	which	WDT
cord-000947-psguw47w	43	27	could	could	MD
cord-000947-psguw47w	43	28	be	be	VB
cord-000947-psguw47w	43	29	identified	identify	VBN
cord-000947-psguw47w	43	30	by	by	IN
cord-000947-psguw47w	43	31	sequence	sequence	NN
cord-000947-psguw47w	43	32	analysis	analysis	NN
cord-000947-psguw47w	43	33	,	,	,
cord-000947-psguw47w	43	34	while	while	IN
cord-000947-psguw47w	43	35	the	the	DT
cord-000947-psguw47w	43	36	interaction	interaction	NN
cord-000947-psguw47w	43	37	sites	site	NNS
cord-000947-psguw47w	43	38	on	on	IN
cord-000947-psguw47w	43	39	the	the	DT
cord-000947-psguw47w	43	40	antigens	antigen	NNS
cord-000947-psguw47w	43	41	were	be	VBD
cord-000947-psguw47w	43	42	called	call	VBN
cord-000947-psguw47w	43	43	the	the	DT
cord-000947-psguw47w	43	44	epitopes	epitope	NNS
cord-000947-psguw47w	43	45	.	.	.
cord-000947-psguw47w	44	1	Many	many	JJ
cord-000947-psguw47w	44	2	bioinformatics	bioinformatics	NN
cord-000947-psguw47w	44	3	software	software	NN
cord-000947-psguw47w	44	4	tools	tool	NNS
cord-000947-psguw47w	44	5	had	have	VBD
cord-000947-psguw47w	44	6	been	be	VBN
cord-000947-psguw47w	44	7	developed	develop	VBN
cord-000947-psguw47w	44	8	to	to	TO
cord-000947-psguw47w	44	9	predict	predict	VB
cord-000947-psguw47w	44	10	epitopes	epitope	NNS
cord-000947-psguw47w	44	11	.	.	.
cord-000947-psguw47w	45	1	B	b	NN
cord-000947-psguw47w	45	2	-	-	HYPH
cord-000947-psguw47w	45	3	cell	cell	NN
cord-000947-psguw47w	45	4	epitopes	epitope	NNS
cord-000947-psguw47w	45	5	typically	typically	RB
cord-000947-psguw47w	45	6	belong	belong	VBP
cord-000947-psguw47w	45	7	to	to	IN
cord-000947-psguw47w	45	8	one	one	CD
cord-000947-psguw47w	45	9	of	of	IN
cord-000947-psguw47w	45	10	the	the	DT
cord-000947-psguw47w	45	11	two	two	CD
cord-000947-psguw47w	45	12	classes	class	NNS
cord-000947-psguw47w	45	13	:	:	:
cord-000947-psguw47w	45	14	linear	linear	JJ
cord-000947-psguw47w	45	15	(	(	-LRB-
cord-000947-psguw47w	45	16	continuous	continuous	JJ
cord-000947-psguw47w	45	17	)	)	-RRB-
cord-000947-psguw47w	45	18	epitopes	epitope	NNS
cord-000947-psguw47w	45	19	or	or	CC
cord-000947-psguw47w	45	20	conformational	conformational	JJ
cord-000947-psguw47w	45	21	(	(	-LRB-
cord-000947-psguw47w	45	22	discontinuous	discontinuous	JJ
cord-000947-psguw47w	45	23	)	)	-RRB-
cord-000947-psguw47w	45	24	epitopes	epitope	NNS
cord-000947-psguw47w	45	25	.	.	.
cord-000947-psguw47w	46	1	At	at	IN
cord-000947-psguw47w	46	2	present	present	JJ
cord-000947-psguw47w	46	3	the	the	DT
cord-000947-psguw47w	46	4	prediction	prediction	NN
cord-000947-psguw47w	46	5	methods	method	NNS
cord-000947-psguw47w	46	6	for	for	IN
cord-000947-psguw47w	46	7	linear	linear	JJ
cord-000947-psguw47w	46	8	epitopes	epitope	NNS
cord-000947-psguw47w	46	9	had	have	VBD
cord-000947-psguw47w	46	10	been	be	VBN
cord-000947-psguw47w	46	11	extensively	extensively	RB
cord-000947-psguw47w	46	12	studied	study	VBN
cord-000947-psguw47w	46	13	and	and	CC
cord-000947-psguw47w	46	14	the	the	DT
cord-000947-psguw47w	46	15	prediction	prediction	NN
cord-000947-psguw47w	46	16	accuracy	accuracy	NN
cord-000947-psguw47w	46	17	had	have	VBD
cord-000947-psguw47w	46	18	been	be	VBN
cord-000947-psguw47w	46	19	improved	improve	VBN
cord-000947-psguw47w	46	20	to	to	TO
cord-000947-psguw47w	46	21	be	be	VB
cord-000947-psguw47w	46	22	as	as	RB
cord-000947-psguw47w	46	23	high	high	JJ
cord-000947-psguw47w	46	24	as	as	IN
cord-000947-psguw47w	46	25	73.37	73.37	CD
cord-000947-psguw47w	46	26	%	%	NN
cord-000947-psguw47w	46	27	[	[	-LRB-
cord-000947-psguw47w	46	28	26	26	CD
cord-000947-psguw47w	46	29	]	]	-RRB-
cord-000947-psguw47w	46	30	.	.	.
cord-000947-psguw47w	47	1	Thus	thus	RB
cord-000947-psguw47w	47	2	linear	linear	JJ
cord-000947-psguw47w	47	3	epitopes	epitopes	NN
cord-000947-psguw47w	47	4	prediction	prediction	NN
cord-000947-psguw47w	47	5	programs	program	NNS
cord-000947-psguw47w	47	6	could	could	MD
cord-000947-psguw47w	47	7	be	be	VB
cord-000947-psguw47w	47	8	used	use	VBN
cord-000947-psguw47w	47	9	to	to	TO
cord-000947-psguw47w	47	10	predict	predict	VB
cord-000947-psguw47w	47	11	the	the	DT
cord-000947-psguw47w	47	12	potential	potential	JJ
cord-000947-psguw47w	47	13	binding	bind	VBG
cord-000947-psguw47w	47	14	sites	site	NNS
cord-000947-psguw47w	47	15	of	of	IN
cord-000947-psguw47w	47	16	HCK	HCK	NNP
cord-000947-psguw47w	47	17	.	.	.
cord-000947-psguw47w	48	1	One	one	CD
cord-000947-psguw47w	48	2	technique	technique	NN
cord-000947-psguw47w	48	3	recently	recently	RB
cord-000947-psguw47w	48	4	developed	develop	VBD
cord-000947-psguw47w	48	5	to	to	TO
cord-000947-psguw47w	48	6	screen	screen	VB
cord-000947-psguw47w	48	7	potential	potential	JJ
cord-000947-psguw47w	48	8	linear	linear	JJ
cord-000947-psguw47w	48	9	epitopes	epitope	NNS
cord-000947-psguw47w	48	10	was	be	VBD
cord-000947-psguw47w	48	11	the	the	DT
cord-000947-psguw47w	48	12	peptide	peptide	NN
cord-000947-psguw47w	48	13	array	array	NN
cord-000947-psguw47w	48	14	membrane	membrane	NN
cord-000947-psguw47w	48	15	technique	technique	NN
cord-000947-psguw47w	48	16	[	[	-LRB-
cord-000947-psguw47w	48	17	27	27	CD
cord-000947-psguw47w	48	18	]	]	-RRB-
cord-000947-psguw47w	48	19	.	.	.
cord-000947-psguw47w	49	1	Peptide	peptide	NN
cord-000947-psguw47w	49	2	fragments	fragment	NNS
cord-000947-psguw47w	49	3	covering	cover	VBG
cord-000947-psguw47w	49	4	the	the	DT
cord-000947-psguw47w	49	5	whole	whole	JJ
cord-000947-psguw47w	49	6	sequence	sequence	NN
cord-000947-psguw47w	49	7	of	of	IN
cord-000947-psguw47w	49	8	a	a	DT
cord-000947-psguw47w	49	9	protein	protein	NN
cord-000947-psguw47w	49	10	antigen	antigen	NN
cord-000947-psguw47w	49	11	were	be	VBD
cord-000947-psguw47w	49	12	synthesized	synthesize	VBN
cord-000947-psguw47w	49	13	and	and	CC
cord-000947-psguw47w	49	14	spotted	spot	VBN
cord-000947-psguw47w	49	15	on	on	IN
cord-000947-psguw47w	49	16	the	the	DT
cord-000947-psguw47w	49	17	membrane	membrane	NN
cord-000947-psguw47w	49	18	,	,	,
cord-000947-psguw47w	49	19	the	the	DT
cord-000947-psguw47w	49	20	membrane	membrane	NN
cord-000947-psguw47w	49	21	was	be	VBD
cord-000947-psguw47w	49	22	then	then	RB
cord-000947-psguw47w	49	23	treated	treat	VBN
cord-000947-psguw47w	49	24	with	with	IN
cord-000947-psguw47w	49	25	antibodies	antibody	NNS
cord-000947-psguw47w	49	26	.	.	.
cord-000947-psguw47w	50	1	After	after	IN
cord-000947-psguw47w	50	2	washing	wash	VBG
cord-000947-psguw47w	50	3	away	away	RB
cord-000947-psguw47w	50	4	the	the	DT
cord-000947-psguw47w	50	5	unbound	unbound	JJ
cord-000947-psguw47w	50	6	antibodies	antibody	NNS
cord-000947-psguw47w	50	7	and	and	CC
cord-000947-psguw47w	50	8	labeling	label	VBG
cord-000947-psguw47w	50	9	the	the	DT
cord-000947-psguw47w	50	10	bound	bind	VBN
cord-000947-psguw47w	50	11	antibodies	antibody	NNS
cord-000947-psguw47w	50	12	with	with	IN
cord-000947-psguw47w	50	13	secondary	secondary	JJ
cord-000947-psguw47w	50	14	chromogenic	chromogenic	JJ
cord-000947-psguw47w	50	15	antibodies	antibody	NNS
cord-000947-psguw47w	50	16	,	,	,
cord-000947-psguw47w	50	17	the	the	DT
cord-000947-psguw47w	50	18	peptide	peptide	NN
cord-000947-psguw47w	50	19	segments	segment	NNS
cord-000947-psguw47w	50	20	of	of	IN
cord-000947-psguw47w	50	21	potential	potential	JJ
cord-000947-psguw47w	50	22	epitopes	epitope	NNS
cord-000947-psguw47w	50	23	could	could	MD
cord-000947-psguw47w	50	24	be	be	VB
cord-000947-psguw47w	50	25	identified	identify	VBN
cord-000947-psguw47w	50	26	.	.	.
cord-000947-psguw47w	51	1	Such	such	JJ
cord-000947-psguw47w	51	2	identified	identify	VBN
cord-000947-psguw47w	51	3	peptides	peptide	NNS
cord-000947-psguw47w	51	4	were	be	VBD
cord-000947-psguw47w	51	5	only	only	RB
cord-000947-psguw47w	51	6	potential	potential	JJ
cord-000947-psguw47w	51	7	epitopes	epitope	NNS
cord-000947-psguw47w	51	8	because	because	IN
cord-000947-psguw47w	51	9	when	when	WRB
cord-000947-psguw47w	51	10	they	-PRON-	PRP
cord-000947-psguw47w	51	11	were	be	VBD
cord-000947-psguw47w	51	12	fixed	fix	VBN
cord-000947-psguw47w	51	13	on	on	IN
cord-000947-psguw47w	51	14	the	the	DT
cord-000947-psguw47w	51	15	membrane	membrane	NN
cord-000947-psguw47w	51	16	their	-PRON-	PRP$
cord-000947-psguw47w	51	17	conformation	conformation	NN
cord-000947-psguw47w	51	18	might	may	MD
cord-000947-psguw47w	51	19	not	not	RB
cord-000947-psguw47w	51	20	be	be	VB
cord-000947-psguw47w	51	21	the	the	DT
cord-000947-psguw47w	51	22	same	same	JJ
cord-000947-psguw47w	51	23	as	as	IN
cord-000947-psguw47w	51	24	when	when	WRB
cord-000947-psguw47w	51	25	they	-PRON-	PRP
cord-000947-psguw47w	51	26	were	be	VBD
cord-000947-psguw47w	51	27	parts	part	NNS
cord-000947-psguw47w	51	28	of	of	IN
cord-000947-psguw47w	51	29	a	a	DT
cord-000947-psguw47w	51	30	protein	protein	NN
cord-000947-psguw47w	51	31	.	.	.
cord-000947-psguw47w	52	1	But	but	CC
cord-000947-psguw47w	52	2	we	-PRON-	PRP
cord-000947-psguw47w	52	3	expected	expect	VBD
cord-000947-psguw47w	52	4	more	more	RBR
cord-000947-psguw47w	52	5	reliable	reliable	JJ
cord-000947-psguw47w	52	6	results	result	NNS
cord-000947-psguw47w	52	7	could	could	MD
cord-000947-psguw47w	52	8	be	be	VB
cord-000947-psguw47w	52	9	deduced	deduce	VBN
cord-000947-psguw47w	52	10	by	by	IN
cord-000947-psguw47w	52	11	combining	combine	VBG
cord-000947-psguw47w	52	12	the	the	DT
cord-000947-psguw47w	52	13	two	two	CD
cord-000947-psguw47w	52	14	methods	method	NNS
cord-000947-psguw47w	52	15	.	.	.
cord-000947-psguw47w	53	1	After	after	IN
cord-000947-psguw47w	53	2	the	the	DT
cord-000947-psguw47w	53	3	potential	potential	JJ
cord-000947-psguw47w	53	4	interaction	interaction	NN
cord-000947-psguw47w	53	5	sites	site	NNS
cord-000947-psguw47w	53	6	of	of	IN
cord-000947-psguw47w	53	7	both	both	DT
cord-000947-psguw47w	53	8	interacting	interact	VBG
cord-000947-psguw47w	53	9	proteins	protein	NNS
cord-000947-psguw47w	53	10	had	have	VBD
cord-000947-psguw47w	53	11	been	be	VBN
cord-000947-psguw47w	53	12	identified	identify	VBN
cord-000947-psguw47w	53	13	,	,	,
cord-000947-psguw47w	53	14	molecule	molecule	NN
cord-000947-psguw47w	53	15	docking	docking	NN
cord-000947-psguw47w	53	16	software	software	NN
cord-000947-psguw47w	53	17	packages	package	NNS
cord-000947-psguw47w	53	18	were	be	VBD
cord-000947-psguw47w	53	19	used	use	VBN
cord-000947-psguw47w	53	20	to	to	TO
cord-000947-psguw47w	53	21	generate	generate	VB
cord-000947-psguw47w	53	22	3D	3d	JJ
cord-000947-psguw47w	53	23	models	model	NNS
cord-000947-psguw47w	53	24	for	for	IN
cord-000947-psguw47w	53	25	the	the	DT
cord-000947-psguw47w	53	26	scFv	scfv	JJ
cord-000947-psguw47w	53	27	-	-	HYPH
cord-000947-psguw47w	53	28	antigen	antigen	NN
cord-000947-psguw47w	53	29	complexes	complex	NNS
cord-000947-psguw47w	53	30	.	.	.
cord-000947-psguw47w	54	1	The	the	DT
cord-000947-psguw47w	54	2	quality	quality	NN
cord-000947-psguw47w	54	3	of	of	IN
cord-000947-psguw47w	54	4	the	the	DT
cord-000947-psguw47w	54	5	3D	3d	JJ
cord-000947-psguw47w	54	6	complex	complex	JJ
cord-000947-psguw47w	54	7	models	model	NNS
cord-000947-psguw47w	54	8	can	can	MD
cord-000947-psguw47w	54	9	be	be	VB
cord-000947-psguw47w	54	10	used	use	VBN
cord-000947-psguw47w	54	11	to	to	TO
cord-000947-psguw47w	54	12	verify	verify	VB
cord-000947-psguw47w	54	13	the	the	DT
cord-000947-psguw47w	54	14	validity	validity	NN
cord-000947-psguw47w	54	15	of	of	IN
cord-000947-psguw47w	54	16	the	the	DT
cord-000947-psguw47w	54	17	previous	previous	JJ
cord-000947-psguw47w	54	18	prediction	prediction	NN
cord-000947-psguw47w	54	19	based	base	VBN
cord-000947-psguw47w	54	20	on	on	IN
cord-000947-psguw47w	54	21	1D	1d	CD
cord-000947-psguw47w	54	22	sequence	sequence	NN
cord-000947-psguw47w	54	23	.	.	.
cord-000947-psguw47w	55	1	The	the	DT
cord-000947-psguw47w	55	2	chaperone	chaperone	NN
cord-000947-psguw47w	55	3	-	-	HYPH
cord-000947-psguw47w	55	4	like	like	JJ
cord-000947-psguw47w	55	5	function	function	NN
cord-000947-psguw47w	55	6	of	of	IN
cord-000947-psguw47w	55	7	the	the	DT
cord-000947-psguw47w	55	8	antibody	antibody	NN
cord-000947-psguw47w	55	9	was	be	VBD
cord-000947-psguw47w	55	10	explained	explain	VBN
cord-000947-psguw47w	55	11	by	by	IN
cord-000947-psguw47w	55	12	investigating	investigate	VBG
cord-000947-psguw47w	55	13	their	-PRON-	PRP$
cord-000947-psguw47w	55	14	interactions	interaction	NNS
cord-000947-psguw47w	55	15	.	.	.
cord-000947-psguw47w	56	1	The	the	DT
cord-000947-psguw47w	56	2	steps	step	NNS
cord-000947-psguw47w	56	3	of	of	IN
cord-000947-psguw47w	56	4	this	this	DT
cord-000947-psguw47w	56	5	research	research	NN
cord-000947-psguw47w	56	6	were	be	VBD
cord-000947-psguw47w	56	7	summarized	summarize	VBN
cord-000947-psguw47w	56	8	as	as	IN
cord-000947-psguw47w	56	9	below	below	RB
cord-000947-psguw47w	56	10	.	.	.
cord-000947-psguw47w	57	1	First	first	RB
cord-000947-psguw47w	57	2	,	,	,
cord-000947-psguw47w	57	3	the	the	DT
cord-000947-psguw47w	57	4	three	three	CD
cord-000947-psguw47w	57	5	-	-	HYPH
cord-000947-psguw47w	57	6	dimensional	dimensional	JJ
cord-000947-psguw47w	57	7	structure	structure	NN
cord-000947-psguw47w	57	8	of	of	IN
cord-000947-psguw47w	57	9	scFv	scFv	NNP
cord-000947-psguw47w	57	10	-	-	HYPH
cord-000947-psguw47w	57	11	A4	A4	NNP
cord-000947-psguw47w	57	12	was	be	VBD
cord-000947-psguw47w	57	13	constructed	construct	VBN
cord-000947-psguw47w	57	14	by	by	IN
cord-000947-psguw47w	57	15	the	the	DT
cord-000947-psguw47w	57	16	homology	homology	NN
cord-000947-psguw47w	57	17	modeling	modeling	NN
cord-000947-psguw47w	57	18	method	method	NN
cord-000947-psguw47w	57	19	.	.	.
cord-000947-psguw47w	58	1	Then	then	RB
cord-000947-psguw47w	58	2	potential	potential	JJ
cord-000947-psguw47w	58	3	epitopes	epitope	NNS
cord-000947-psguw47w	58	4	of	of	IN
cord-000947-psguw47w	58	5	HCK	HCK	NNP
cord-000947-psguw47w	58	6	were	be	VBD
cord-000947-psguw47w	58	7	predicted	predict	VBN
cord-000947-psguw47w	58	8	by	by	IN
cord-000947-psguw47w	58	9	software	software	NN
cord-000947-psguw47w	58	10	tools	tool	NNS
cord-000947-psguw47w	58	11	and	and	CC
cord-000947-psguw47w	58	12	the	the	DT
cord-000947-psguw47w	58	13	peptide	peptide	NN
cord-000947-psguw47w	58	14	array	array	NN
cord-000947-psguw47w	58	15	membrane	membrane	NN
cord-000947-psguw47w	58	16	experiment	experiment	NN
cord-000947-psguw47w	58	17	.	.	.
cord-000947-psguw47w	59	1	The	the	DT
cord-000947-psguw47w	59	2	3D	3d	JJ
cord-000947-psguw47w	59	3	models	model	NNS
cord-000947-psguw47w	59	4	of	of	IN
cord-000947-psguw47w	59	5	scFv	scFv	NNP
cord-000947-psguw47w	59	6	-	-	HYPH
cord-000947-psguw47w	59	7	A4-HCK	A4-HCK	NNP
cord-000947-psguw47w	59	8	complex	complex	NN
cord-000947-psguw47w	59	9	were	be	VBD
cord-000947-psguw47w	59	10	built	build	VBN
cord-000947-psguw47w	59	11	by	by	IN
cord-000947-psguw47w	59	12	orientational	orientational	JJ
cord-000947-psguw47w	59	13	docking	docking	NN
cord-000947-psguw47w	59	14	.	.	.
cord-000947-psguw47w	60	1	Finally	finally	RB
cord-000947-psguw47w	60	2	,	,	,
cord-000947-psguw47w	60	3	we	-PRON-	PRP
cord-000947-psguw47w	60	4	analyzed	analyze	VBD
cord-000947-psguw47w	60	5	the	the	DT
cord-000947-psguw47w	60	6	interaction	interaction	NN
cord-000947-psguw47w	60	7	between	between	IN
cord-000947-psguw47w	60	8	HCK	HCK	NNP
cord-000947-psguw47w	60	9	and	and	CC
cord-000947-psguw47w	60	10	scFv	scFv	NNP
cord-000947-psguw47w	60	11	-	-	HYPH
cord-000947-psguw47w	60	12	A4	a4	NN
cord-000947-psguw47w	60	13	and	and	CC
cord-000947-psguw47w	60	14	speculated	speculate	VBD
cord-000947-psguw47w	60	15	the	the	DT
cord-000947-psguw47w	60	16	mechanism	mechanism	NN
cord-000947-psguw47w	60	17	underlying	underlie	VBG
cord-000947-psguw47w	60	18	the	the	DT
cord-000947-psguw47w	60	19	chaperone	chaperone	NN
cord-000947-psguw47w	60	20	-	-	HYPH
cord-000947-psguw47w	60	21	like	like	JJ
cord-000947-psguw47w	60	22	function	function	NN
cord-000947-psguw47w	60	23	of	of	IN
cord-000947-psguw47w	60	24	the	the	DT
cord-000947-psguw47w	60	25	scFv	scfv	JJ
cord-000947-psguw47w	60	26	-	-	HYPH
cord-000947-psguw47w	60	27	A4	a4	NN
cord-000947-psguw47w	60	28	.	.	.
cord-000947-psguw47w	61	1	This	this	DT
cord-000947-psguw47w	61	2	research	research	NN
cord-000947-psguw47w	61	3	also	also	RB
cord-000947-psguw47w	61	4	provided	provide	VBD
cord-000947-psguw47w	61	5	a	a	DT
cord-000947-psguw47w	61	6	new	new	JJ
cord-000947-psguw47w	61	7	approach	approach	NN
cord-000947-psguw47w	61	8	for	for	IN
cord-000947-psguw47w	61	9	studying	study	VBG
cord-000947-psguw47w	61	10	antibodyantigen	antibodyantigen	NN
cord-000947-psguw47w	61	11	interactions	interaction	NNS
cord-000947-psguw47w	61	12	based	base	VBN
cord-000947-psguw47w	61	13	on	on	IN
cord-000947-psguw47w	61	14	the	the	DT
cord-000947-psguw47w	61	15	peptide	peptide	NN
cord-000947-psguw47w	61	16	array	array	NN
cord-000947-psguw47w	61	17	membrane	membrane	NN
cord-000947-psguw47w	61	18	experiment	experiment	NN
cord-000947-psguw47w	61	19	and	and	CC
cord-000947-psguw47w	61	20	bioinformatics	bioinformatics	NN
cord-000947-psguw47w	61	21	software	software	NN
cord-000947-psguw47w	61	22	tools	tool	NNS
cord-000947-psguw47w	61	23	.	.	.
cord-000947-psguw47w	62	1	The	the	DT
cord-000947-psguw47w	62	2	CDRs	cdr	NNS
cord-000947-psguw47w	62	3	and	and	CC
cord-000947-psguw47w	62	4	the	the	DT
cord-000947-psguw47w	62	5	linker	linker	NN
cord-000947-psguw47w	62	6	of	of	IN
cord-000947-psguw47w	62	7	scFv	scFv	NNP
cord-000947-psguw47w	62	8	-	-	HYPH
cord-000947-psguw47w	62	9	A4	A4	NNP
cord-000947-psguw47w	62	10	were	be	VBD
cord-000947-psguw47w	62	11	inferred	infer	VBN
cord-000947-psguw47w	62	12	from	from	IN
cord-000947-psguw47w	62	13	the	the	DT
cord-000947-psguw47w	62	14	alignment	alignment	NN
cord-000947-psguw47w	62	15	as	as	IN
cord-000947-psguw47w	62	16	shown	show	VBN
cord-000947-psguw47w	62	17	in	in	IN
cord-000947-psguw47w	62	18	Figure	figure	NN
cord-000947-psguw47w	62	19	1	1	CD
cord-000947-psguw47w	62	20	.	.	.
cord-000947-psguw47w	63	1	The	the	DT
cord-000947-psguw47w	63	2	model	model	NN
cord-000947-psguw47w	63	3	of	of	IN
cord-000947-psguw47w	63	4	the	the	DT
cord-000947-psguw47w	63	5	antibody	antibody	NN
cord-000947-psguw47w	63	6	was	be	VBD
cord-000947-psguw47w	63	7	constructed	construct	VBN
cord-000947-psguw47w	63	8	by	by	IN
cord-000947-psguw47w	63	9	the	the	DT
cord-000947-psguw47w	63	10	Modeller	Modeller	NNP
cord-000947-psguw47w	63	11	9v7	9v7	CD
cord-000947-psguw47w	63	12	program	program	NN
cord-000947-psguw47w	63	13	as	as	IN
cord-000947-psguw47w	63	14	shown	show	VBN
cord-000947-psguw47w	63	15	in	in	IN
cord-000947-psguw47w	63	16	Figure	figure	NN
cord-000947-psguw47w	63	17	2a	2a	CD
cord-000947-psguw47w	63	18	.	.	.
cord-000947-psguw47w	64	1	The	the	DT
cord-000947-psguw47w	64	2	distributions	distribution	NNS
cord-000947-psguw47w	64	3	of	of	IN
cord-000947-psguw47w	64	4	W	W	NNP
cord-000947-psguw47w	64	5	-	-	HYPH
cord-000947-psguw47w	64	6	Y	Y	NNP
cord-000947-psguw47w	64	7	dihedral	dihedral	JJ
cord-000947-psguw47w	64	8	angles	angle	NNS
cord-000947-psguw47w	64	9	of	of	IN
cord-000947-psguw47w	64	10	the	the	DT
cord-000947-psguw47w	64	11	backbone	backbone	NN
cord-000947-psguw47w	64	12	were	be	VBD
cord-000947-psguw47w	64	13	checked	check	VBN
cord-000947-psguw47w	64	14	by	by	IN
cord-000947-psguw47w	64	15	the	the	DT
cord-000947-psguw47w	64	16	Procheck	Procheck	NNP
cord-000947-psguw47w	64	17	program	program	NN
cord-000947-psguw47w	64	18	[	[	-LRB-
cord-000947-psguw47w	64	19	28	28	CD
cord-000947-psguw47w	64	20	]	]	-RRB-
cord-000947-psguw47w	64	21	.	.	.
cord-000947-psguw47w	65	1	A	a	DT
cord-000947-psguw47w	65	2	Ramachandran	Ramachandran	NNP
cord-000947-psguw47w	65	3	map	map	NN
cord-000947-psguw47w	65	4	was	be	VBD
cord-000947-psguw47w	65	5	used	use	VBN
cord-000947-psguw47w	65	6	to	to	TO
cord-000947-psguw47w	65	7	describe	describe	VB
cord-000947-psguw47w	65	8	the	the	DT
cord-000947-psguw47w	65	9	dihedral	dihedral	JJ
cord-000947-psguw47w	65	10	angles	angle	NNS
cord-000947-psguw47w	65	11	of	of	IN
cord-000947-psguw47w	65	12	the	the	DT
cord-000947-psguw47w	65	13	low	low	JJ
cord-000947-psguw47w	65	14	-	-	HYPH
cord-000947-psguw47w	65	15	energy	energy	NN
cord-000947-psguw47w	65	16	conformation	conformation	NN
cord-000947-psguw47w	65	17	(	(	-LRB-
cord-000947-psguw47w	65	18	Figure	figure	NN
cord-000947-psguw47w	65	19	2b	2b	CD
cord-000947-psguw47w	65	20	)	)	-RRB-
cord-000947-psguw47w	65	21	.	.	.
cord-000947-psguw47w	66	1	It	-PRON-	PRP
cord-000947-psguw47w	66	2	showed	show	VBD
cord-000947-psguw47w	66	3	that	that	IN
cord-000947-psguw47w	66	4	87.4	87.4	CD
cord-000947-psguw47w	66	5	%	%	NN
cord-000947-psguw47w	66	6	of	of	IN
cord-000947-psguw47w	66	7	the	the	DT
cord-000947-psguw47w	66	8	residues	residue	NNS
cord-000947-psguw47w	66	9	fell	fall	VBD
cord-000947-psguw47w	66	10	into	into	IN
cord-000947-psguw47w	66	11	the	the	DT
cord-000947-psguw47w	66	12	best	good	JJS
cord-000947-psguw47w	66	13	area	area	NN
cord-000947-psguw47w	66	14	,	,	,
cord-000947-psguw47w	66	15	12.1	12.1	CD
cord-000947-psguw47w	66	16	%	%	NN
cord-000947-psguw47w	66	17	of	of	IN
cord-000947-psguw47w	66	18	the	the	DT
cord-000947-psguw47w	66	19	residues	residue	NNS
cord-000947-psguw47w	66	20	into	into	IN
cord-000947-psguw47w	66	21	the	the	DT
cord-000947-psguw47w	66	22	other	other	JJ
cord-000947-psguw47w	66	23	license	license	NN
cord-000947-psguw47w	66	24	area	area	NN
cord-000947-psguw47w	66	25	,	,	,
cord-000947-psguw47w	66	26	0.5	0.5	CD
cord-000947-psguw47w	66	27	%	%	NN
cord-000947-psguw47w	66	28	of	of	IN
cord-000947-psguw47w	66	29	the	the	DT
cord-000947-psguw47w	66	30	residues	residue	NNS
cord-000947-psguw47w	66	31	into	into	IN
cord-000947-psguw47w	66	32	the	the	DT
cord-000947-psguw47w	66	33	permitted	permit	VBN
cord-000947-psguw47w	66	34	area	area	NN
cord-000947-psguw47w	66	35	,	,	,
cord-000947-psguw47w	66	36	0.0	0.0	CD
cord-000947-psguw47w	66	37	%	%	NN
cord-000947-psguw47w	66	38	of	of	IN
cord-000947-psguw47w	66	39	the	the	DT
cord-000947-psguw47w	66	40	residues	residue	NNS
cord-000947-psguw47w	66	41	into	into	IN
cord-000947-psguw47w	66	42	the	the	DT
cord-000947-psguw47w	66	43	not	not	RB
cord-000947-psguw47w	66	44	allowed	allow	VBN
cord-000947-psguw47w	66	45	area	area	NN
cord-000947-psguw47w	66	46	.	.	.
cord-000947-psguw47w	67	1	Therefore	therefore	RB
cord-000947-psguw47w	67	2	,	,	,
cord-000947-psguw47w	67	3	dihedral	dihedral	JJ
cord-000947-psguw47w	67	4	angles	angle	NNS
cord-000947-psguw47w	67	5	of	of	IN
cord-000947-psguw47w	67	6	the	the	DT
cord-000947-psguw47w	67	7	structure	structure	NN
cord-000947-psguw47w	67	8	of	of	IN
cord-000947-psguw47w	67	9	the	the	DT
cord-000947-psguw47w	67	10	model	model	NN
cord-000947-psguw47w	67	11	were	be	VBD
cord-000947-psguw47w	67	12	reasonable	reasonable	JJ
cord-000947-psguw47w	67	13	.	.	.
cord-000947-psguw47w	68	1	For	for	IN
cord-000947-psguw47w	68	2	87.65	87.65	CD
cord-000947-psguw47w	68	3	%	%	NN
cord-000947-psguw47w	68	4	residues	residue	NNS
cord-000947-psguw47w	68	5	the	the	DT
cord-000947-psguw47w	68	6	3D-1D	3d-1d	CD
cord-000947-psguw47w	68	7	compatibility	compatibility	NN
cord-000947-psguw47w	68	8	score	score	NN
cord-000947-psguw47w	68	9	is	be	VBZ
cord-000947-psguw47w	68	10	greater	great	JJR
cord-000947-psguw47w	68	11	than	than	IN
cord-000947-psguw47w	68	12	0.2	0.2	CD
cord-000947-psguw47w	68	13	by	by	IN
cord-000947-psguw47w	68	14	Verify-3D	Verify-3D	NNP
cord-000947-psguw47w	68	15	[	[	-LRB-
cord-000947-psguw47w	68	16	29	29	CD
cord-000947-psguw47w	68	17	]	]	-RRB-
cord-000947-psguw47w	69	1	(	(	-LRB-
cord-000947-psguw47w	69	2	A	a	DT
cord-000947-psguw47w	69	3	high	high	JJ
cord-000947-psguw47w	69	4	score	score	NN
cord-000947-psguw47w	69	5	indicated	indicate	VBD
cord-000947-psguw47w	69	6	the	the	DT
cord-000947-psguw47w	69	7	compatibility	compatibility	NN
cord-000947-psguw47w	69	8	of	of	IN
cord-000947-psguw47w	69	9	the	the	DT
cord-000947-psguw47w	69	10	sequence	sequence	NN
cord-000947-psguw47w	69	11	and	and	CC
cord-000947-psguw47w	69	12	the	the	DT
cord-000947-psguw47w	69	13	tertiary	tertiary	JJ
cord-000947-psguw47w	69	14	structure	structure	NN
cord-000947-psguw47w	69	15	is	be	VBZ
cord-000947-psguw47w	69	16	good	good	JJ
cord-000947-psguw47w	69	17	)	)	-RRB-
cord-000947-psguw47w	69	18	.	.	.
cord-000947-psguw47w	70	1	The	the	DT
cord-000947-psguw47w	70	2	amino	amino	NN
cord-000947-psguw47w	70	3	acids	acid	NNS
cord-000947-psguw47w	70	4	with	with	IN
cord-000947-psguw47w	70	5	scores	score	NNS
cord-000947-psguw47w	70	6	less	less	JJR
cord-000947-psguw47w	70	7	than	than	IN
cord-000947-psguw47w	70	8	0.2	0.2	CD
cord-000947-psguw47w	70	9	were	be	VBD
cord-000947-psguw47w	70	10	GLY112-LYS142	GLY112-LYS142	NNP
cord-000947-psguw47w	70	11	which	which	WDT
cord-000947-psguw47w	70	12	belonged	belong	VBD
cord-000947-psguw47w	70	13	to	to	IN
cord-000947-psguw47w	70	14	the	the	DT
cord-000947-psguw47w	70	15	linker	linker	NN
cord-000947-psguw47w	70	16	segment	segment	NN
cord-000947-psguw47w	70	17	(	(	-LRB-
cord-000947-psguw47w	70	18	Figure	figure	NN
cord-000947-psguw47w	70	19	2c	2c	NN
cord-000947-psguw47w	70	20	)	)	-RRB-
cord-000947-psguw47w	70	21	.	.	.
cord-000947-psguw47w	71	1	Since	since	IN
cord-000947-psguw47w	71	2	no	no	DT
cord-000947-psguw47w	71	3	template	template	NN
cord-000947-psguw47w	71	4	was	be	VBD
cord-000947-psguw47w	71	5	used	use	VBN
cord-000947-psguw47w	71	6	for	for	IN
cord-000947-psguw47w	71	7	modeling	model	VBG
cord-000947-psguw47w	71	8	the	the	DT
cord-000947-psguw47w	71	9	linker	linker	NN
cord-000947-psguw47w	71	10	the	the	DT
cord-000947-psguw47w	71	11	poorer	poor	JJR
cord-000947-psguw47w	71	12	model	model	NN
cord-000947-psguw47w	71	13	result	result	NN
cord-000947-psguw47w	71	14	of	of	IN
cord-000947-psguw47w	71	15	this	this	DT
cord-000947-psguw47w	71	16	area	area	NN
cord-000947-psguw47w	71	17	was	be	VBD
cord-000947-psguw47w	71	18	expected	expect	VBN
cord-000947-psguw47w	71	19	.	.	.
cord-000947-psguw47w	72	1	The	the	DT
cord-000947-psguw47w	72	2	above	above	JJ
cord-000947-psguw47w	72	3	evaluations	evaluation	NNS
cord-000947-psguw47w	72	4	verified	verify	VBN
cord-000947-psguw47w	72	5	that	that	IN
cord-000947-psguw47w	72	6	the	the	DT
cord-000947-psguw47w	72	7	three	three	CD
cord-000947-psguw47w	72	8	-	-	HYPH
cord-000947-psguw47w	72	9	dimensional	dimensional	JJ
cord-000947-psguw47w	72	10	model	model	NN
cord-000947-psguw47w	72	11	of	of	IN
cord-000947-psguw47w	72	12	scFv	scFv	NNP
cord-000947-psguw47w	72	13	-	-	HYPH
cord-000947-psguw47w	72	14	A4	A4	NNP
cord-000947-psguw47w	72	15	was	be	VBD
cord-000947-psguw47w	72	16	reasonable	reasonable	JJ
cord-000947-psguw47w	72	17	.	.	.
cord-000947-psguw47w	73	1	The	the	DT
cord-000947-psguw47w	73	2	peptide	peptide	JJ
cord-000947-psguw47w	73	3	array	array	NN
cord-000947-psguw47w	73	4	membrane	membrane	NN
cord-000947-psguw47w	73	5	was	be	VBD
cord-000947-psguw47w	73	6	shown	show	VBN
cord-000947-psguw47w	73	7	in	in	IN
cord-000947-psguw47w	73	8	Figure	Figure	NNP
cord-000947-psguw47w	73	9	3	3	CD
cord-000947-psguw47w	73	10	.	.	.
cord-000947-psguw47w	74	1	Each	each	DT
cord-000947-psguw47w	74	2	square	square	NN
cord-000947-psguw47w	74	3	contained	contain	VBD
cord-000947-psguw47w	74	4	a	a	DT
cord-000947-psguw47w	74	5	12	12	CD
cord-000947-psguw47w	74	6	mer	mer	NNP
cord-000947-psguw47w	74	7	peptide	peptide	NN
cord-000947-psguw47w	74	8	.	.	.
cord-000947-psguw47w	75	1	First	first	JJ
cord-000947-psguw47w	75	2	set	set	NN
cord-000947-psguw47w	75	3	of	of	IN
cord-000947-psguw47w	75	4	peptides	peptide	NNS
cord-000947-psguw47w	75	5	covered	cover	VBD
cord-000947-psguw47w	75	6	HCK	HCK	NNP
cord-000947-psguw47w	75	7	sequence	sequence	NN
cord-000947-psguw47w	75	8	was	be	VBD
cord-000947-psguw47w	75	9	spotted	spot	VBN
cord-000947-psguw47w	75	10	in	in	IN
cord-000947-psguw47w	75	11	squares	square	NNS
cord-000947-psguw47w	75	12	A1	A1	NNP
cord-000947-psguw47w	75	13	to	to	IN
cord-000947-psguw47w	75	14	M9	M9	NNP
cord-000947-psguw47w	75	15	.	.	.
cord-000947-psguw47w	76	1	Peptides	peptide	NNS
cord-000947-psguw47w	76	2	at	at	IN
cord-000947-psguw47w	76	3	the	the	DT
cord-000947-psguw47w	76	4	spots	spot	NNS
cord-000947-psguw47w	76	5	N9	N9	NNP
cord-000947-psguw47w	76	6	to	to	IN
cord-000947-psguw47w	76	7	T5	T5	NNP
cord-000947-psguw47w	76	8	were	be	VBD
cord-000947-psguw47w	76	9	the	the	DT
cord-000947-psguw47w	76	10	peptides	peptide	NNS
cord-000947-psguw47w	76	11	picked	pick	VBN
cord-000947-psguw47w	76	12	from	from	IN
cord-000947-psguw47w	76	13	first	first	JJ
cord-000947-psguw47w	76	14	set	set	NN
cord-000947-psguw47w	76	15	in	in	IN
cord-000947-psguw47w	76	16	which	which	WDT
cord-000947-psguw47w	76	17	first	first	JJ
cord-000947-psguw47w	76	18	amino	amino	NN
cord-000947-psguw47w	76	19	acid	acid	NN
cord-000947-psguw47w	76	20	sequence	sequence	NN
cord-000947-psguw47w	76	21	numbers	number	NNS
cord-000947-psguw47w	76	22	were	be	VBD
cord-000947-psguw47w	76	23	odd	odd	JJ
cord-000947-psguw47w	76	24	number	number	NN
cord-000947-psguw47w	76	25	;	;	:
cord-000947-psguw47w	76	26	this	this	DT
cord-000947-psguw47w	76	27	just	just	RB
cord-000947-psguw47w	76	28	served	serve	VBD
cord-000947-psguw47w	76	29	as	as	IN
cord-000947-psguw47w	76	30	a	a	DT
cord-000947-psguw47w	76	31	repeat	repeat	NN
cord-000947-psguw47w	76	32	experiment	experiment	NN
cord-000947-psguw47w	76	33	.	.	.
cord-000947-psguw47w	77	1	After	after	IN
cord-000947-psguw47w	77	2	secondary	secondary	JJ
cord-000947-psguw47w	77	3	antibodies	antibody	NNS
cord-000947-psguw47w	77	4	and	and	CC
cord-000947-psguw47w	77	5	chromogenic	chromogenic	JJ
cord-000947-psguw47w	77	6	substrates	substrate	NNS
cord-000947-psguw47w	77	7	were	be	VBD
cord-000947-psguw47w	77	8	added	add	VBN
cord-000947-psguw47w	77	9	,	,	,
cord-000947-psguw47w	77	10	six	six	CD
cord-000947-psguw47w	77	11	sets	set	NNS
cord-000947-psguw47w	77	12	of	of	IN
cord-000947-psguw47w	77	13	continuous	continuous	JJ
cord-000947-psguw47w	77	14	spots	spot	NNS
cord-000947-psguw47w	77	15	were	be	VBD
cord-000947-psguw47w	77	16	developed	develop	VBN
cord-000947-psguw47w	77	17	.	.	.
cord-000947-psguw47w	78	1	Each	each	DT
cord-000947-psguw47w	78	2	set	set	NN
cord-000947-psguw47w	78	3	of	of	IN
cord-000947-psguw47w	78	4	the	the	DT
cord-000947-psguw47w	78	5	continuous	continuous	JJ
cord-000947-psguw47w	78	6	spots	spot	NNS
cord-000947-psguw47w	78	7	corresponds	correspond	VBZ
cord-000947-psguw47w	78	8	to	to	IN
cord-000947-psguw47w	78	9	a	a	DT
cord-000947-psguw47w	78	10	peptide	peptide	JJ
cord-000947-psguw47w	78	11	segment	segment	NN
cord-000947-psguw47w	78	12	of	of	IN
cord-000947-psguw47w	78	13	HCK	HCK	NNP
cord-000947-psguw47w	78	14	.	.	.
cord-000947-psguw47w	79	1	Spots	spot	NNS
cord-000947-psguw47w	79	2	A2-A6	a2-a6	PRP
cord-000947-psguw47w	79	3	correspond	correspond	VBP
cord-000947-psguw47w	79	4	to	to	IN
cord-000947-psguw47w	79	5	Asn5-Tyr14	Asn5-Tyr14	NNP
cord-000947-psguw47w	79	6	of	of	IN
cord-000947-psguw47w	79	7	HCK	HCK	NNP
cord-000947-psguw47w	80	1	;	;	:
cord-000947-psguw47w	80	2	Spots	spot	NNS
cord-000947-psguw47w	80	3	of	of	IN
cord-000947-psguw47w	80	4	E3-E13	E3-E13	NNP
cord-000947-psguw47w	80	5	correspond	correspond	VB
cord-000947-psguw47w	80	6	to	to	IN
cord-000947-psguw47w	80	7	Ser129-Lys138	Ser129-Lys138	NNP
cord-000947-psguw47w	80	8	of	of	IN
cord-000947-psguw47w	80	9	HCK	HCK	NNP
cord-000947-psguw47w	80	10	;	;	:
cord-000947-psguw47w	80	11	Spots	spot	NNS
cord-000947-psguw47w	80	12	of	of	IN
cord-000947-psguw47w	80	13	F17-F21	F17-F21	NNS
cord-000947-psguw47w	80	14	correspond	correspond	VBP
cord-000947-psguw47w	80	15	to	to	IN
cord-000947-psguw47w	80	16	Lys170-Met179	Lys170-Met179	NNP
cord-000947-psguw47w	80	17	of	of	IN
cord-000947-psguw47w	80	18	HCK	HCK	NNP
cord-000947-psguw47w	80	19	;	;	:
cord-000947-psguw47w	80	20	Spots	spot	NNS
cord-000947-psguw47w	80	21	of	of	IN
cord-000947-psguw47w	80	22	I3-I12	I3-I12	NNP
cord-000947-psguw47w	80	23	correspond	correspond	VBP
cord-000947-psguw47w	80	24	to	to	IN
cord-000947-psguw47w	80	25	Glu248-Leu257	Glu248-Leu257	NNP
cord-000947-psguw47w	80	26	of	of	IN
cord-000947-psguw47w	80	27	HCK	HCK	NNP
cord-000947-psguw47w	80	28	;	;	:
cord-000947-psguw47w	80	29	Spots	spot	NNS
cord-000947-psguw47w	80	30	of	of	IN
cord-000947-psguw47w	80	31	I22-I29	i22-i29	NN
cord-000947-psguw47w	80	32	correspond	correspond	VBP
cord-000947-psguw47w	80	33	to	to	IN
cord-000947-psguw47w	80	34	Lys265-Asn274	Lys265-Asn274	NNP
cord-000947-psguw47w	80	35	of	of	IN
cord-000947-psguw47w	80	36	HCK	HCK	NNP
cord-000947-psguw47w	80	37	;	;	:
cord-000947-psguw47w	80	38	Spots	spot	NNS
cord-000947-psguw47w	80	39	of	of	IN
cord-000947-psguw47w	80	40	K5-K14	K5-K14	NNP
cord-000947-psguw47w	80	41	correspond	correspond	VBP
cord-000947-psguw47w	80	42	to	to	IN
cord-000947-psguw47w	80	43	Thr313-Thr322	Thr313-Thr322	NNP
cord-000947-psguw47w	80	44	of	of	IN
cord-000947-psguw47w	80	45	HCK	HCK	NNP
cord-000947-psguw47w	80	46	.	.	.
cord-000947-psguw47w	81	1	These	these	DT
cord-000947-psguw47w	81	2	six	six	CD
cord-000947-psguw47w	81	3	peptides	peptide	NNS
cord-000947-psguw47w	81	4	were	be	VBD
cord-000947-psguw47w	81	5	potential	potential	JJ
cord-000947-psguw47w	81	6	scFv	scfv	JJ
cord-000947-psguw47w	81	7	-	-	HYPH
cord-000947-psguw47w	81	8	A4	a4	NN
cord-000947-psguw47w	81	9	binding	binding	NN
cord-000947-psguw47w	81	10	sites	site	NNS
cord-000947-psguw47w	81	11	on	on	IN
cord-000947-psguw47w	81	12	HCK	HCK	NNP
cord-000947-psguw47w	81	13	.	.	.
cord-000947-psguw47w	82	1	There	there	EX
cord-000947-psguw47w	82	2	were	be	VBD
cord-000947-psguw47w	82	3	11	11	CD
cord-000947-psguw47w	82	4	linear	linear	JJ
cord-000947-psguw47w	82	5	epitopes	epitope	NNS
cord-000947-psguw47w	82	6	predicted	predict	VBN
cord-000947-psguw47w	82	7	by	by	IN
cord-000947-psguw47w	82	8	ElliPro	ElliPro	NNP
cord-000947-psguw47w	82	9	[	[	-LRB-
cord-000947-psguw47w	82	10	30	30	CD
cord-000947-psguw47w	82	11	]	]	-RRB-
cord-000947-psguw47w	82	12	and	and	CC
cord-000947-psguw47w	82	13	15	15	CD
cord-000947-psguw47w	82	14	linear	linear	JJ
cord-000947-psguw47w	82	15	epitopes	epitope	NNS
cord-000947-psguw47w	82	16	predicted	predict	VBN
cord-000947-psguw47w	82	17	by	by	IN
cord-000947-psguw47w	82	18	FBCpred	FBCpred	NNP
cord-000947-psguw47w	82	19	[	[	-LRB-
cord-000947-psguw47w	82	20	26	26	CD
cord-000947-psguw47w	82	21	]	]	-RRB-
cord-000947-psguw47w	82	22	.	.	.
cord-000947-psguw47w	83	1	These	these	DT
cord-000947-psguw47w	83	2	predicted	predict	VBN
cord-000947-psguw47w	83	3	epitopes	epitope	NNS
cord-000947-psguw47w	83	4	were	be	VBD
cord-000947-psguw47w	83	5	potential	potential	JJ
cord-000947-psguw47w	83	6	binding	bind	VBG
cord-000947-psguw47w	83	7	sites	site	NNS
cord-000947-psguw47w	83	8	for	for	IN
cord-000947-psguw47w	83	9	all	all	DT
cord-000947-psguw47w	83	10	antibodies	antibody	NNS
cord-000947-psguw47w	83	11	.	.	.
cord-000947-psguw47w	84	1	For	for	IN
cord-000947-psguw47w	84	2	example	example	NN
cord-000947-psguw47w	84	3	,	,	,
cord-000947-psguw47w	84	4	some	some	DT
cord-000947-psguw47w	84	5	predicted	predict	VBN
cord-000947-psguw47w	84	6	peptides	peptide	NNS
cord-000947-psguw47w	84	7	might	may	MD
cord-000947-psguw47w	84	8	be	be	VB
cord-000947-psguw47w	84	9	the	the	DT
cord-000947-psguw47w	84	10	epitopes	epitope	NNS
cord-000947-psguw47w	84	11	for	for	IN
cord-000947-psguw47w	84	12	anti	anti	JJ
cord-000947-psguw47w	84	13	-	-	JJ
cord-000947-psguw47w	84	14	HCK	HCK	NNP
cord-000947-psguw47w	84	15	antibodies	antibody	NNS
cord-000947-psguw47w	84	16	with	with	IN
cord-000947-psguw47w	84	17	no	no	DT
cord-000947-psguw47w	84	18	chaperone	chaperone	NN
cord-000947-psguw47w	84	19	-	-	HYPH
cord-000947-psguw47w	84	20	like	like	JJ
cord-000947-psguw47w	84	21	functions	function	NNS
cord-000947-psguw47w	84	22	.	.	.
cord-000947-psguw47w	85	1	There	there	EX
cord-000947-psguw47w	85	2	were	be	VBD
cord-000947-psguw47w	85	3	a	a	DT
cord-000947-psguw47w	85	4	total	total	NN
cord-000947-psguw47w	85	5	of	of	IN
cord-000947-psguw47w	85	6	eight	eight	CD
cord-000947-psguw47w	85	7	overlapping	overlap	VBG
cord-000947-psguw47w	85	8	epitopes	epitope	NNS
cord-000947-psguw47w	85	9	in	in	IN
cord-000947-psguw47w	85	10	the	the	DT
cord-000947-psguw47w	85	11	two	two	CD
cord-000947-psguw47w	85	12	groups	group	NNS
cord-000947-psguw47w	85	13	of	of	IN
cord-000947-psguw47w	85	14	epitopes	epitope	NNS
cord-000947-psguw47w	85	15	predicted	predict	VBN
cord-000947-psguw47w	85	16	by	by	IN
cord-000947-psguw47w	85	17	both	both	DT
cord-000947-psguw47w	85	18	methods	method	NNS
cord-000947-psguw47w	85	19	.	.	.
cord-000947-psguw47w	86	1	These	these	DT
cord-000947-psguw47w	86	2	eight	eight	CD
cord-000947-psguw47w	86	3	epitopes	epitope	NNS
cord-000947-psguw47w	86	4	were	be	VBD
cord-000947-psguw47w	86	5	shown	show	VBN
cord-000947-psguw47w	86	6	in	in	IN
cord-000947-psguw47w	86	7	Table	Table	NNP
cord-000947-psguw47w	86	8	1	1	CD
cord-000947-psguw47w	86	9	.	.	.
cord-000947-psguw47w	87	1	For	for	IN
cord-000947-psguw47w	87	2	these	these	DT
cord-000947-psguw47w	87	3	eight	eight	CD
cord-000947-psguw47w	87	4	peptides	peptide	NNS
cord-000947-psguw47w	87	5	,	,	,
cord-000947-psguw47w	87	6	four	four	CD
cord-000947-psguw47w	87	7	peptides	peptide	NNS
cord-000947-psguw47w	87	8	fell	fall	VBD
cord-000947-psguw47w	87	9	in	in	IN
cord-000947-psguw47w	87	10	the	the	DT
cord-000947-psguw47w	87	11	Nterminal	Nterminal	NNP
cord-000947-psguw47w	87	12	domain	domain	NN
cord-000947-psguw47w	87	13	,	,	,
cord-000947-psguw47w	87	14	one	one	CD
cord-000947-psguw47w	87	15	peptide	peptide	NN
cord-000947-psguw47w	87	16	fell	fall	VBD
cord-000947-psguw47w	87	17	in	in	IN
cord-000947-psguw47w	87	18	the	the	DT
cord-000947-psguw47w	87	19	linker	linker	NN
cord-000947-psguw47w	87	20	area	area	NN
cord-000947-psguw47w	87	21	and	and	CC
cord-000947-psguw47w	87	22	three	three	CD
cord-000947-psguw47w	87	23	fell	fall	VBD
cord-000947-psguw47w	87	24	in	in	IN
cord-000947-psguw47w	87	25	the	the	DT
cord-000947-psguw47w	87	26	C	c	NN
cord-000947-psguw47w	87	27	-	-	HYPH
cord-000947-psguw47w	87	28	terminal	terminal	NN
cord-000947-psguw47w	87	29	domain	domain	NN
cord-000947-psguw47w	87	30	.	.	.
cord-000947-psguw47w	88	1	Comparing	compare	VBG
cord-000947-psguw47w	88	2	to	to	IN
cord-000947-psguw47w	88	3	the	the	DT
cord-000947-psguw47w	88	4	peptide	peptide	JJ
cord-000947-psguw47w	88	5	array	array	NN
cord-000947-psguw47w	88	6	membrane	membrane	NN
cord-000947-psguw47w	88	7	experiment	experiment	NN
cord-000947-psguw47w	88	8	results	result	NNS
cord-000947-psguw47w	88	9	,	,	,
cord-000947-psguw47w	88	10	there	there	EX
cord-000947-psguw47w	88	11	were	be	VBD
cord-000947-psguw47w	88	12	two	two	CD
cord-000947-psguw47w	88	13	overlapping	overlap	VBG
cord-000947-psguw47w	88	14	sequences	sequence	NNS
cord-000947-psguw47w	88	15	,	,	,
cord-000947-psguw47w	88	16	LYS170-MET179	LYS170-MET179	NNP
cord-000947-psguw47w	88	17	and	and	CC
cord-000947-psguw47w	88	18	LYS265-ASN274	LYS265-ASN274	NNP
cord-000947-psguw47w	88	19	,	,	,
cord-000947-psguw47w	88	20	which	which	WDT
cord-000947-psguw47w	88	21	were	be	VBD
cord-000947-psguw47w	88	22	positive	positive	JJ
cord-000947-psguw47w	88	23	in	in	IN
cord-000947-psguw47w	88	24	both	both	DT
cord-000947-psguw47w	88	25	methods	method	NNS
cord-000947-psguw47w	88	26	.	.	.
cord-000947-psguw47w	89	1	An	an	DT
cord-000947-psguw47w	89	2	orientational	orientational	JJ
cord-000947-psguw47w	89	3	docking	docking	NN
cord-000947-psguw47w	89	4	of	of	IN
cord-000947-psguw47w	89	5	scFv	scFv	NNP
cord-000947-psguw47w	89	6	-	-	HYPH
cord-000947-psguw47w	89	7	A4	A4	NNP
cord-000947-psguw47w	89	8	and	and	CC
cord-000947-psguw47w	89	9	HCK	HCK	NNP
cord-000947-psguw47w	89	10	epitopes	epitope	NNS
cord-000947-psguw47w	89	11	was	be	VBD
cord-000947-psguw47w	89	12	carried	carry	VBN
cord-000947-psguw47w	89	13	out	out	RP
cord-000947-psguw47w	89	14	by	by	IN
cord-000947-psguw47w	89	15	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	89	16	[	[	-LRB-
cord-000947-psguw47w	89	17	31	31	CD
cord-000947-psguw47w	89	18	]	]	-RRB-
cord-000947-psguw47w	89	19	docking	docking	NN
cord-000947-psguw47w	89	20	server	server	NN
cord-000947-psguw47w	89	21	.	.	.
cord-000947-psguw47w	90	1	If	if	IN
cord-000947-psguw47w	90	2	we	-PRON-	PRP
cord-000947-psguw47w	90	3	combined	combine	VBD
cord-000947-psguw47w	90	4	the	the	DT
cord-000947-psguw47w	90	5	results	result	NNS
cord-000947-psguw47w	90	6	from	from	IN
cord-000947-psguw47w	90	7	peptide	peptide	JJ
cord-000947-psguw47w	90	8	array	array	NN
cord-000947-psguw47w	90	9	membrane	membrane	NN
cord-000947-psguw47w	90	10	experiment	experiment	NN
cord-000947-psguw47w	90	11	and	and	CC
cord-000947-psguw47w	90	12	bioinformatics	bioinformatics	NN
cord-000947-psguw47w	90	13	predictions	prediction	NNS
cord-000947-psguw47w	90	14	,	,	,
cord-000947-psguw47w	90	15	we	-PRON-	PRP
cord-000947-psguw47w	90	16	could	could	MD
cord-000947-psguw47w	90	17	reduce	reduce	VB
cord-000947-psguw47w	90	18	the	the	DT
cord-000947-psguw47w	90	19	workload	workload	NN
cord-000947-psguw47w	90	20	by	by	IN
cord-000947-psguw47w	90	21	only	only	RB
cord-000947-psguw47w	90	22	docking	dock	VBG
cord-000947-psguw47w	90	23	the	the	DT
cord-000947-psguw47w	90	24	two	two	CD
cord-000947-psguw47w	90	25	overlapping	overlap	VBG
cord-000947-psguw47w	90	26	peptides	peptide	NNS
cord-000947-psguw47w	90	27	.	.	.
cord-000947-psguw47w	91	1	For	for	IN
cord-000947-psguw47w	91	2	experimental	experimental	JJ
cord-000947-psguw47w	91	3	completeness	completeness	NN
cord-000947-psguw47w	91	4	,	,	,
cord-000947-psguw47w	91	5	we	-PRON-	PRP
cord-000947-psguw47w	91	6	did	do	VBD
cord-000947-psguw47w	91	7	the	the	DT
cord-000947-psguw47w	91	8	orientational	orientational	JJ
cord-000947-psguw47w	91	9	docking	docking	NN
cord-000947-psguw47w	91	10	for	for	IN
cord-000947-psguw47w	91	11	all	all	DT
cord-000947-psguw47w	91	12	of	of	IN
cord-000947-psguw47w	91	13	the	the	DT
cord-000947-psguw47w	91	14	six	six	CD
cord-000947-psguw47w	91	15	peptides	peptide	NNS
cord-000947-psguw47w	91	16	screened	screen	VBN
cord-000947-psguw47w	91	17	out	out	RP
cord-000947-psguw47w	91	18	by	by	IN
cord-000947-psguw47w	91	19	the	the	DT
cord-000947-psguw47w	91	20	peptide	peptide	NN
cord-000947-psguw47w	91	21	array	array	NN
cord-000947-psguw47w	91	22	experiment	experiment	NN
cord-000947-psguw47w	91	23	.	.	.
cord-000947-psguw47w	92	1	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	92	2	did	do	VBD
cord-000947-psguw47w	92	3	not	not	RB
cord-000947-psguw47w	92	4	generate	generate	VB
cord-000947-psguw47w	92	5	any	any	DT
cord-000947-psguw47w	92	6	reasonable	reasonable	JJ
cord-000947-psguw47w	92	7	models	model	NNS
cord-000947-psguw47w	92	8	for	for	IN
cord-000947-psguw47w	92	9	four	four	CD
cord-000947-psguw47w	92	10	of	of	IN
cord-000947-psguw47w	92	11	the	the	DT
cord-000947-psguw47w	92	12	six	six	CD
cord-000947-psguw47w	92	13	peptides	peptide	NNS
cord-000947-psguw47w	92	14	(	(	-LRB-
cord-000947-psguw47w	92	15	SER129-LYS138	ser129-lys138	JJ
cord-000947-psguw47w	92	16	,	,	,
cord-000947-psguw47w	92	17	GLU248-LEU257	GLU248-LEU257	NNP
cord-000947-psguw47w	92	18	,	,	,
cord-000947-psguw47w	92	19	THR313-THR322	THR313-THR322	NNP
cord-000947-psguw47w	92	20	,	,	,
cord-000947-psguw47w	92	21	ASN5-TYR14	ASN5-TYR14	NNP
cord-000947-psguw47w	92	22	)	)	-RRB-
cord-000947-psguw47w	92	23	.	.	.
cord-000947-psguw47w	93	1	It	-PRON-	PRP
cord-000947-psguw47w	93	2	was	be	VBD
cord-000947-psguw47w	93	3	interesting	interesting	JJ
cord-000947-psguw47w	93	4	because	because	IN
cord-000947-psguw47w	93	5	it	-PRON-	PRP
cord-000947-psguw47w	93	6	agreed	agree	VBD
cord-000947-psguw47w	93	7	with	with	IN
cord-000947-psguw47w	93	8	the	the	DT
cord-000947-psguw47w	93	9	bioinformatics	bioinformatics	NN
cord-000947-psguw47w	93	10	prediction	prediction	NN
cord-000947-psguw47w	93	11	that	that	IN
cord-000947-psguw47w	93	12	they	-PRON-	PRP
cord-000947-psguw47w	93	13	were	be	VBD
cord-000947-psguw47w	93	14	not	not	RB
cord-000947-psguw47w	93	15	epitopes	epitope	NNS
cord-000947-psguw47w	93	16	.	.	.
cord-000947-psguw47w	94	1	To	to	TO
cord-000947-psguw47w	94	2	look	look	VB
cord-000947-psguw47w	94	3	into	into	IN
cord-000947-psguw47w	94	4	the	the	DT
cord-000947-psguw47w	94	5	details	detail	NNS
cord-000947-psguw47w	94	6	of	of	IN
cord-000947-psguw47w	94	7	the	the	DT
cord-000947-psguw47w	94	8	six	six	CD
cord-000947-psguw47w	94	9	peptides	peptide	NNS
cord-000947-psguw47w	94	10	,	,	,
cord-000947-psguw47w	94	11	we	-PRON-	PRP
cord-000947-psguw47w	94	12	investigated	investigate	VBD
cord-000947-psguw47w	94	13	their	-PRON-	PRP$
cord-000947-psguw47w	94	14	structure	structure	NN
cord-000947-psguw47w	94	15	feature	feature	NN
cord-000947-psguw47w	94	16	.	.	.
cord-000947-psguw47w	95	1	As	as	IN
cord-000947-psguw47w	95	2	shown	show	VBN
cord-000947-psguw47w	95	3	in	in	IN
cord-000947-psguw47w	95	4	Figure	Figure	NNP
cord-000947-psguw47w	95	5	4	4	CD
cord-000947-psguw47w	95	6	,	,	,
cord-000947-psguw47w	95	7	the	the	DT
cord-000947-psguw47w	95	8	first	first	JJ
cord-000947-psguw47w	95	9	three	three	CD
cord-000947-psguw47w	95	10	peptides	peptide	NNS
cord-000947-psguw47w	95	11	were	be	VBD
cord-000947-psguw47w	95	12	embedded	embed	VBN
cord-000947-psguw47w	95	13	inside	inside	IN
cord-000947-psguw47w	95	14	the	the	DT
cord-000947-psguw47w	95	15	HCK	HCK	NNP
cord-000947-psguw47w	95	16	monomers	monomer	NNS
cord-000947-psguw47w	95	17	,	,	,
cord-000947-psguw47w	95	18	thus	thus	RB
cord-000947-psguw47w	95	19	they	-PRON-	PRP
cord-000947-psguw47w	95	20	were	be	VBD
cord-000947-psguw47w	95	21	not	not	RB
cord-000947-psguw47w	95	22	accessible	accessible	JJ
cord-000947-psguw47w	95	23	by	by	IN
cord-000947-psguw47w	95	24	scFv	scFv	NNP
cord-000947-psguw47w	95	25	-	-	HYPH
cord-000947-psguw47w	95	26	A4	a4	NN
cord-000947-psguw47w	95	27	.	.	.
cord-000947-psguw47w	96	1	For	for	IN
cord-000947-psguw47w	96	2	peptide	peptide	JJ
cord-000947-psguw47w	96	3	ASN5-TYR14	ASN5-TYR14	NNP
cord-000947-psguw47w	96	4	,	,	,
cord-000947-psguw47w	96	5	it	-PRON-	PRP
cord-000947-psguw47w	96	6	was	be	VBD
cord-000947-psguw47w	96	7	buried	bury	VBN
cord-000947-psguw47w	96	8	between	between	IN
cord-000947-psguw47w	96	9	the	the	DT
cord-000947-psguw47w	96	10	dimerization	dimerization	NN
cord-000947-psguw47w	96	11	interfaces	interface	NNS
cord-000947-psguw47w	96	12	of	of	IN
cord-000947-psguw47w	96	13	the	the	DT
cord-000947-psguw47w	96	14	two	two	CD
cord-000947-psguw47w	96	15	HCK	HCK	NNP
cord-000947-psguw47w	96	16	monomers	monomer	NNS
cord-000947-psguw47w	96	17	therefore	therefore	RB
cord-000947-psguw47w	96	18	it	-PRON-	PRP
cord-000947-psguw47w	96	19	was	be	VBD
cord-000947-psguw47w	96	20	also	also	RB
cord-000947-psguw47w	96	21	inaccessible	inaccessible	JJ
cord-000947-psguw47w	96	22	for	for	IN
cord-000947-psguw47w	96	23	scFv	scfv	JJ
cord-000947-psguw47w	96	24	-	-	HYPH
cord-000947-psguw47w	96	25	A4	a4	NN
cord-000947-psguw47w	96	26	.	.	.
cord-000947-psguw47w	97	1	Only	only	RB
cord-000947-psguw47w	97	2	the	the	DT
cord-000947-psguw47w	97	3	rest	rest	NN
cord-000947-psguw47w	97	4	two	two	CD
cord-000947-psguw47w	97	5	peptides	peptide	NNS
cord-000947-psguw47w	97	6	(	(	-LRB-
cord-000947-psguw47w	97	7	LYS170-MET179	LYS170-MET179	NNP
cord-000947-psguw47w	97	8	and	and	CC
cord-000947-psguw47w	97	9	LYS265-ASN274	LYS265-ASN274	NNP
cord-000947-psguw47w	97	10	could	could	MD
cord-000947-psguw47w	97	11	be	be	VB
cord-000947-psguw47w	97	12	docked	dock	VBN
cord-000947-psguw47w	97	13	to	to	IN
cord-000947-psguw47w	97	14	scFv	scFv	NNP
cord-000947-psguw47w	97	15	-	-	HYPH
cord-000947-psguw47w	97	16	A4	a4	NN
cord-000947-psguw47w	97	17	by	by	IN
cord-000947-psguw47w	97	18	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	97	19	Server	Server	NNP
cord-000947-psguw47w	97	20	and	and	CC
cord-000947-psguw47w	97	21	two	two	CD
cord-000947-psguw47w	97	22	complex	complex	JJ
cord-000947-psguw47w	97	23	models	model	NNS
cord-000947-psguw47w	97	24	were	be	VBD
cord-000947-psguw47w	97	25	obtained	obtain	VBN
cord-000947-psguw47w	97	26	.	.	.
cord-000947-psguw47w	98	1	Because	because	IN
cord-000947-psguw47w	98	2	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	98	3	used	use	VBD
cord-000947-psguw47w	98	4	rigid	rigid	JJ
cord-000947-psguw47w	98	5	body	body	NN
cord-000947-psguw47w	98	6	approximation	approximation	NN
cord-000947-psguw47w	98	7	,	,	,
cord-000947-psguw47w	98	8	to	to	TO
cord-000947-psguw47w	98	9	obtain	obtain	VB
cord-000947-psguw47w	98	10	a	a	DT
cord-000947-psguw47w	98	11	more	more	RBR
cord-000947-psguw47w	98	12	accurate	accurate	JJ
cord-000947-psguw47w	98	13	protein	protein	NN
cord-000947-psguw47w	98	14	complex	complex	JJ
cord-000947-psguw47w	98	15	structure	structure	NN
cord-000947-psguw47w	98	16	,	,	,
cord-000947-psguw47w	98	17	complex	complex	JJ
cord-000947-psguw47w	98	18	models	model	NNS
cord-000947-psguw47w	98	19	generated	generate	VBN
cord-000947-psguw47w	98	20	by	by	IN
cord-000947-psguw47w	98	21	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	98	22	were	be	VBD
cord-000947-psguw47w	98	23	redocked	redocke	VBN
cord-000947-psguw47w	98	24	by	by	IN
cord-000947-psguw47w	98	25	RosettaDock	RosettaDock	NNP
cord-000947-psguw47w	98	26	[	[	-LRB-
cord-000947-psguw47w	98	27	32	32	CD
cord-000947-psguw47w	98	28	]	]	-RRB-
cord-000947-psguw47w	98	29	.	.	.
cord-000947-psguw47w	99	1	which	which	WDT
cord-000947-psguw47w	99	2	implemented	implement	VBD
cord-000947-psguw47w	99	3	the	the	DT
cord-000947-psguw47w	99	4	flexible	flexible	JJ
cord-000947-psguw47w	99	5	docking	docking	NN
cord-000947-psguw47w	99	6	method	method	NN
cord-000947-psguw47w	99	7	and	and	CC
cord-000947-psguw47w	99	8	came	come	VBD
cord-000947-psguw47w	99	9	with	with	IN
cord-000947-psguw47w	99	10	a	a	DT
cord-000947-psguw47w	99	11	more	more	RBR
cord-000947-psguw47w	99	12	accurate	accurate	JJ
cord-000947-psguw47w	99	13	scoring	scoring	NN
cord-000947-psguw47w	99	14	function	function	NN
cord-000947-psguw47w	99	15	.	.	.
cord-000947-psguw47w	100	1	RosettaDock	RosettaDock	NNP
cord-000947-psguw47w	100	2	generated	generate	VBD
cord-000947-psguw47w	100	3	1000	1000	CD
cord-000947-psguw47w	100	4	new	new	JJ
cord-000947-psguw47w	100	5	complex	complex	JJ
cord-000947-psguw47w	100	6	models	model	NNS
cord-000947-psguw47w	100	7	for	for	IN
cord-000947-psguw47w	100	8	each	each	DT
cord-000947-psguw47w	100	9	of	of	IN
cord-000947-psguw47w	100	10	the	the	DT
cord-000947-psguw47w	100	11	two	two	CD
cord-000947-psguw47w	100	12	epitopes	epitope	NNS
cord-000947-psguw47w	100	13	respectively	respectively	RB
cord-000947-psguw47w	100	14	.	.	.
cord-000947-psguw47w	101	1	The	the	DT
cord-000947-psguw47w	101	2	output	output	NN
cord-000947-psguw47w	101	3	results	result	NNS
cord-000947-psguw47w	101	4	were	be	VBD
cord-000947-psguw47w	101	5	ranked	rank	VBN
cord-000947-psguw47w	101	6	by	by	IN
cord-000947-psguw47w	101	7	docking	docking	NN
cord-000947-psguw47w	101	8	scores	score	NNS
cord-000947-psguw47w	101	9	.	.	.
cord-000947-psguw47w	102	1	We	-PRON-	PRP
cord-000947-psguw47w	102	2	discarded	discard	VBD
cord-000947-psguw47w	102	3	models	model	NNS
cord-000947-psguw47w	102	4	in	in	IN
cord-000947-psguw47w	102	5	which	which	WDT
cord-000947-psguw47w	102	6	the	the	DT
cord-000947-psguw47w	102	7	binding	bind	VBG
cord-000947-psguw47w	102	8	sites	site	NNS
cord-000947-psguw47w	102	9	of	of	IN
cord-000947-psguw47w	102	10	the	the	DT
cord-000947-psguw47w	102	11	antibody	antibody	NN
cord-000947-psguw47w	102	12	were	be	VBD
cord-000947-psguw47w	102	13	outside	outside	IN
cord-000947-psguw47w	102	14	the	the	DT
cord-000947-psguw47w	102	15	CDR	cdr	NN
cord-000947-psguw47w	102	16	regions	region	NNS
cord-000947-psguw47w	102	17	and	and	CC
cord-000947-psguw47w	102	18	picked	pick	VBD
cord-000947-psguw47w	102	19	the	the	DT
cord-000947-psguw47w	102	20	best	good	JJS
cord-000947-psguw47w	102	21	complex	complex	JJ
cord-000947-psguw47w	102	22	models	model	NNS
cord-000947-psguw47w	102	23	by	by	IN
cord-000947-psguw47w	102	24	the	the	DT
cord-000947-psguw47w	102	25	best	good	JJS
cord-000947-psguw47w	102	26	rank	rank	NN
cord-000947-psguw47w	102	27	scores	score	NNS
cord-000947-psguw47w	102	28	.	.	.
cord-000947-psguw47w	103	1	Two	two	CD
cord-000947-psguw47w	103	2	final	final	JJ
cord-000947-psguw47w	103	3	complex	complex	JJ
cord-000947-psguw47w	103	4	models	model	NNS
cord-000947-psguw47w	103	5	for	for	IN
cord-000947-psguw47w	103	6	the	the	DT
cord-000947-psguw47w	103	7	two	two	CD
cord-000947-psguw47w	103	8	epitopes	epitope	NNS
cord-000947-psguw47w	103	9	were	be	VBD
cord-000947-psguw47w	103	10	named	name	VBN
cord-000947-psguw47w	103	11	as	as	IN
cord-000947-psguw47w	103	12	complex	complex	NN
cord-000947-psguw47w	103	13	-	-	:
cord-000947-psguw47w	103	14	I	i	NN
cord-000947-psguw47w	103	15	and	and	CC
cord-000947-psguw47w	103	16	complex	complex	JJ
cord-000947-psguw47w	103	17	-	-	HYPH
cord-000947-psguw47w	103	18	II	ii	NN
cord-000947-psguw47w	103	19	respectively	respectively	RB
cord-000947-psguw47w	103	20	and	and	CC
cord-000947-psguw47w	103	21	shown	show	VBN
cord-000947-psguw47w	103	22	in	in	IN
cord-000947-psguw47w	103	23	Figure	Figure	NNP
cord-000947-psguw47w	103	24	5	5	CD
cord-000947-psguw47w	103	25	.	.	.
cord-000947-psguw47w	104	1	Antibodies	antibody	NNS
cord-000947-psguw47w	104	2	and	and	CC
cord-000947-psguw47w	104	3	their	-PRON-	PRP$
cord-000947-psguw47w	104	4	functional	functional	JJ
cord-000947-psguw47w	104	5	derivatives	derivative	NNS
cord-000947-psguw47w	104	6	such	such	JJ
cord-000947-psguw47w	104	7	as	as	IN
cord-000947-psguw47w	104	8	scFv	scFv	NNP
cord-000947-psguw47w	104	9	and	and	CC
cord-000947-psguw47w	104	10	Fab	Fab	NNP
cord-000947-psguw47w	104	11	are	be	VBP
cord-000947-psguw47w	104	12	known	know	VBN
cord-000947-psguw47w	104	13	for	for	IN
cord-000947-psguw47w	104	14	their	-PRON-	PRP$
cord-000947-psguw47w	104	15	specific	specific	JJ
cord-000947-psguw47w	104	16	binding	binding	NN
cord-000947-psguw47w	104	17	and	and	CC
cord-000947-psguw47w	104	18	have	have	VBP
cord-000947-psguw47w	104	19	already	already	RB
cord-000947-psguw47w	104	20	been	be	VBN
cord-000947-psguw47w	104	21	used	use	VBN
cord-000947-psguw47w	104	22	in	in	IN
cord-000947-psguw47w	104	23	protein	protein	NN
cord-000947-psguw47w	104	24	folding	folding	NN
cord-000947-psguw47w	104	25	researches	research	NNS
cord-000947-psguw47w	104	26	[	[	-LRB-
cord-000947-psguw47w	104	27	9	9	CD
cord-000947-psguw47w	104	28	]	]	-RRB-
cord-000947-psguw47w	104	29	.	.	.
cord-000947-psguw47w	105	1	Antibodies	antibody	NNS
cord-000947-psguw47w	105	2	with	with	IN
cord-000947-psguw47w	105	3	a	a	DT
cord-000947-psguw47w	105	4	chaperone	chaperone	NN
cord-000947-psguw47w	105	5	-	-	HYPH
cord-000947-psguw47w	105	6	like	like	JJ
cord-000947-psguw47w	105	7	function	function	NN
cord-000947-psguw47w	105	8	had	have	VBD
cord-000947-psguw47w	105	9	the	the	DT
cord-000947-psguw47w	105	10	potential	potential	NN
cord-000947-psguw47w	105	11	to	to	TO
cord-000947-psguw47w	105	12	be	be	VB
cord-000947-psguw47w	105	13	used	use	VBN
cord-000947-psguw47w	105	14	as	as	IN
cord-000947-psguw47w	105	15	therapeutic	therapeutic	JJ
cord-000947-psguw47w	105	16	agents	agent	NNS
cord-000947-psguw47w	105	17	for	for	IN
cord-000947-psguw47w	105	18	misfolding	misfolde	VBG
cord-000947-psguw47w	105	19	diseases	disease	NNS
cord-000947-psguw47w	105	20	.	.	.
cord-000947-psguw47w	106	1	More	More	JJR
cord-000947-psguw47w	106	2	researches	research	NNS
cord-000947-psguw47w	106	3	need	need	VBP
cord-000947-psguw47w	106	4	to	to	TO
cord-000947-psguw47w	106	5	be	be	VB
cord-000947-psguw47w	106	6	done	do	VBN
cord-000947-psguw47w	106	7	to	to	TO
cord-000947-psguw47w	106	8	elucidate	elucidate	VB
cord-000947-psguw47w	106	9	the	the	DT
cord-000947-psguw47w	106	10	mechanism	mechanism	NN
cord-000947-psguw47w	106	11	of	of	IN
cord-000947-psguw47w	106	12	antibodies	antibody	NNS
cord-000947-psguw47w	106	13	'	'	POS
cord-000947-psguw47w	106	14	chaperone	chaperone	NN
cord-000947-psguw47w	106	15	-	-	HYPH
cord-000947-psguw47w	106	16	like	like	JJ
cord-000947-psguw47w	106	17	function	function	NN
cord-000947-psguw47w	106	18	.	.	.
cord-000947-psguw47w	107	1	A	a	DT
cord-000947-psguw47w	107	2	protein	protein	NN
cord-000947-psguw47w	107	3	antigen	antigen	NN
cord-000947-psguw47w	107	4	usually	usually	RB
cord-000947-psguw47w	107	5	carries	carry	VBZ
cord-000947-psguw47w	107	6	more	more	JJR
cord-000947-psguw47w	107	7	than	than	IN
cord-000947-psguw47w	107	8	one	one	CD
cord-000947-psguw47w	107	9	epitope	epitope	NN
cord-000947-psguw47w	107	10	,	,	,
cord-000947-psguw47w	107	11	therefore	therefore	RB
cord-000947-psguw47w	107	12	an	an	DT
cord-000947-psguw47w	107	13	antigen	antigen	NN
cord-000947-psguw47w	107	14	can	can	MD
cord-000947-psguw47w	107	15	interact	interact	VB
cord-000947-psguw47w	107	16	with	with	IN
cord-000947-psguw47w	107	17	several	several	JJ
cord-000947-psguw47w	107	18	different	different	JJ
cord-000947-psguw47w	107	19	types	type	NNS
cord-000947-psguw47w	107	20	of	of	IN
cord-000947-psguw47w	107	21	antibodies	antibody	NNS
cord-000947-psguw47w	107	22	.	.	.
cord-000947-psguw47w	108	1	Obviously	obviously	RB
cord-000947-psguw47w	108	2	the	the	DT
cord-000947-psguw47w	108	3	different	different	JJ
cord-000947-psguw47w	108	4	types	type	NNS
cord-000947-psguw47w	108	5	of	of	IN
cord-000947-psguw47w	108	6	antibodies	antibody	NNS
cord-000947-psguw47w	108	7	have	have	VBP
cord-000947-psguw47w	108	8	different	different	JJ
cord-000947-psguw47w	108	9	impacts	impact	NNS
cord-000947-psguw47w	108	10	on	on	IN
cord-000947-psguw47w	108	11	the	the	DT
cord-000947-psguw47w	108	12	antigen	antigen	NN
cord-000947-psguw47w	108	13	's	's	POS
cord-000947-psguw47w	108	14	properties	property	NNS
cord-000947-psguw47w	108	15	.	.	.
cord-000947-psguw47w	109	1	We	-PRON-	PRP
cord-000947-psguw47w	109	2	had	have	VBD
cord-000947-psguw47w	109	3	previously	previously	RB
cord-000947-psguw47w	109	4	screened	screen	VBN
cord-000947-psguw47w	109	5	out	out	RP
cord-000947-psguw47w	109	6	several	several	JJ
cord-000947-psguw47w	109	7	scFvs	scFvs	NNP
cord-000947-psguw47w	109	8	for	for	IN
cord-000947-psguw47w	109	9	HCK	HCK	NNP
cord-000947-psguw47w	109	10	and	and	CC
cord-000947-psguw47w	109	11	one	one	CD
cord-000947-psguw47w	109	12	of	of	IN
cord-000947-psguw47w	109	13	them	-PRON-	PRP
cord-000947-psguw47w	110	1	named	name	VBN
cord-000947-psguw47w	110	2	scFv	scFv	NNP
cord-000947-psguw47w	110	3	-	-	HYPH
cord-000947-psguw47w	110	4	A4	A4	NNP
cord-000947-psguw47w	110	5	showed	show	VBD
cord-000947-psguw47w	110	6	strong	strong	JJ
cord-000947-psguw47w	110	7	chaperone	chaperone	NN
cord-000947-psguw47w	110	8	-	-	HYPH
cord-000947-psguw47w	110	9	like	like	JJ
cord-000947-psguw47w	110	10	activity	activity	NN
cord-000947-psguw47w	110	11	.	.	.
cord-000947-psguw47w	111	1	To	to	TO
cord-000947-psguw47w	111	2	elucidate	elucidate	VB
cord-000947-psguw47w	111	3	why	why	WRB
cord-000947-psguw47w	111	4	scFv	scFv	NNP
cord-000947-psguw47w	111	5	-	-	HYPH
cord-000947-psguw47w	111	6	A4	A4	NNP
cord-000947-psguw47w	111	7	had	have	VBD
cord-000947-psguw47w	111	8	the	the	DT
cord-000947-psguw47w	111	9	chaperone	chaperone	NN
cord-000947-psguw47w	111	10	-	-	HYPH
cord-000947-psguw47w	111	11	like	like	JJ
cord-000947-psguw47w	111	12	function	function	NN
cord-000947-psguw47w	111	13	,	,	,
cord-000947-psguw47w	111	14	we	-PRON-	PRP
cord-000947-psguw47w	111	15	combined	combine	VBD
cord-000947-psguw47w	111	16	computer	computer	NN
cord-000947-psguw47w	111	17	modeling	modeling	NN
cord-000947-psguw47w	111	18	and	and	CC
cord-000947-psguw47w	111	19	peptide	peptide	NN
cord-000947-psguw47w	111	20	array	array	NN
cord-000947-psguw47w	111	21	membrane	membrane	NN
cord-000947-psguw47w	111	22	technique	technique	NN
cord-000947-psguw47w	111	23	to	to	TO
cord-000947-psguw47w	111	24	study	study	VB
cord-000947-psguw47w	111	25	the	the	DT
cord-000947-psguw47w	111	26	interactions	interaction	NNS
cord-000947-psguw47w	111	27	between	between	IN
cord-000947-psguw47w	111	28	scFv	scFv	NNP
cord-000947-psguw47w	111	29	-	-	HYPH
cord-000947-psguw47w	111	30	A4	A4	NNP
cord-000947-psguw47w	111	31	and	and	CC
cord-000947-psguw47w	111	32	HCK	HCK	NNP
cord-000947-psguw47w	111	33	.	.	.
cord-000947-psguw47w	112	1	Firstly	firstly	RB
cord-000947-psguw47w	112	2	,	,	,
cord-000947-psguw47w	112	3	bioinformatics	bioinformatics	NN
cord-000947-psguw47w	112	4	software	software	NN
cord-000947-psguw47w	112	5	tools	tool	NNS
cord-000947-psguw47w	112	6	were	be	VBD
cord-000947-psguw47w	112	7	used	use	VBN
cord-000947-psguw47w	112	8	to	to	TO
cord-000947-psguw47w	112	9	predict	predict	VB
cord-000947-psguw47w	112	10	the	the	DT
cord-000947-psguw47w	112	11	interacting	interact	VBG
cord-000947-psguw47w	112	12	sites	site	NNS
cord-000947-psguw47w	112	13	between	between	IN
cord-000947-psguw47w	112	14	scFv	scfv	JJ
cord-000947-psguw47w	112	15	-	-	HYPH
cord-000947-psguw47w	112	16	A4	A4	NNP
cord-000947-psguw47w	112	17	and	and	CC
cord-000947-psguw47w	112	18	HCK	HCK	NNP
cord-000947-psguw47w	112	19	and	and	CC
cord-000947-psguw47w	112	20	then	then	RB
cord-000947-psguw47w	112	21	the	the	DT
cord-000947-psguw47w	112	22	results	result	NNS
cord-000947-psguw47w	112	23	were	be	VBD
cord-000947-psguw47w	112	24	combined	combine	VBN
cord-000947-psguw47w	112	25	with	with	IN
cord-000947-psguw47w	112	26	the	the	DT
cord-000947-psguw47w	112	27	peptide	peptide	NN
cord-000947-psguw47w	112	28	array	array	NN
cord-000947-psguw47w	112	29	membrane	membrane	NN
cord-000947-psguw47w	112	30	experiment	experiment	NN
cord-000947-psguw47w	112	31	results	result	NNS
cord-000947-psguw47w	112	32	to	to	TO
cord-000947-psguw47w	112	33	build	build	VB
cord-000947-psguw47w	112	34	the	the	DT
cord-000947-psguw47w	112	35	3D	3d	JJ
cord-000947-psguw47w	112	36	models	model	NNS
cord-000947-psguw47w	112	37	of	of	IN
cord-000947-psguw47w	112	38	the	the	DT
cord-000947-psguw47w	112	39	binding	binding	JJ
cord-000947-psguw47w	112	40	complex	complex	NN
cord-000947-psguw47w	112	41	.	.	.
cord-000947-psguw47w	113	1	The	the	DT
cord-000947-psguw47w	113	2	prediction	prediction	NN
cord-000947-psguw47w	113	3	of	of	IN
cord-000947-psguw47w	113	4	protein	protein	NN
cord-000947-psguw47w	113	5	-	-	HYPH
cord-000947-psguw47w	113	6	protein	protein	NN
cord-000947-psguw47w	113	7	interactions	interaction	NNS
cord-000947-psguw47w	113	8	by	by	IN
cord-000947-psguw47w	113	9	computer	computer	NN
cord-000947-psguw47w	113	10	is	be	VBZ
cord-000947-psguw47w	113	11	still	still	RB
cord-000947-psguw47w	113	12	a	a	DT
cord-000947-psguw47w	113	13	challenging	challenging	JJ
cord-000947-psguw47w	113	14	subject	subject	NN
cord-000947-psguw47w	113	15	,	,	,
cord-000947-psguw47w	113	16	and	and	CC
cord-000947-psguw47w	113	17	it	-PRON-	PRP
cord-000947-psguw47w	113	18	is	be	VBZ
cord-000947-psguw47w	113	19	inappropriate	inappropriate	JJ
cord-000947-psguw47w	113	20	to	to	TO
cord-000947-psguw47w	113	21	rely	rely	VB
cord-000947-psguw47w	113	22	entirely	entirely	RB
cord-000947-psguw47w	113	23	on	on	IN
cord-000947-psguw47w	113	24	the	the	DT
cord-000947-psguw47w	113	25	energy	energy	NN
cord-000947-psguw47w	113	26	scoring	scoring	NN
cord-000947-psguw47w	113	27	function	function	NN
cord-000947-psguw47w	113	28	to	to	TO
cord-000947-psguw47w	113	29	filter	filter	VB
cord-000947-psguw47w	113	30	the	the	DT
cord-000947-psguw47w	113	31	results	result	NNS
cord-000947-psguw47w	113	32	directly	directly	RB
cord-000947-psguw47w	113	33	.	.	.
cord-000947-psguw47w	114	1	Thus	thus	RB
cord-000947-psguw47w	114	2	,	,	,
cord-000947-psguw47w	114	3	we	-PRON-	PRP
cord-000947-psguw47w	114	4	used	use	VBD
cord-000947-psguw47w	114	5	the	the	DT
cord-000947-psguw47w	114	6	orientational	orientational	JJ
cord-000947-psguw47w	114	7	docking	docking	NN
cord-000947-psguw47w	114	8	method	method	NN
cord-000947-psguw47w	114	9	followed	follow	VBN
cord-000947-psguw47w	114	10	by	by	IN
cord-000947-psguw47w	114	11	redocking	redocke	VBG
cord-000947-psguw47w	114	12	,	,	,
cord-000947-psguw47w	114	13	the	the	DT
cord-000947-psguw47w	114	14	cumulated	cumulate	VBN
cord-000947-psguw47w	114	15	results	result	NNS
cord-000947-psguw47w	114	16	were	be	VBD
cord-000947-psguw47w	114	17	then	then	RB
cord-000947-psguw47w	114	18	sorted	sort	VBN
cord-000947-psguw47w	114	19	by	by	IN
cord-000947-psguw47w	114	20	the	the	DT
cord-000947-psguw47w	114	21	scoring	scoring	NN
cord-000947-psguw47w	114	22	function	function	NN
cord-000947-psguw47w	114	23	to	to	TO
cord-000947-psguw47w	114	24	get	get	VB
cord-000947-psguw47w	114	25	reliable	reliable	JJ
cord-000947-psguw47w	114	26	protein	protein	NN
cord-000947-psguw47w	114	27	-	-	HYPH
cord-000947-psguw47w	114	28	protein	protein	NN
cord-000947-psguw47w	114	29	binding	binding	NN
cord-000947-psguw47w	114	30	models	model	NNS
cord-000947-psguw47w	114	31	.	.	.
cord-000947-psguw47w	115	1	First	first	RB
cord-000947-psguw47w	115	2	the	the	DT
cord-000947-psguw47w	115	3	binding	bind	VBG
cord-000947-psguw47w	115	4	sites	site	NNS
cord-000947-psguw47w	115	5	of	of	IN
cord-000947-psguw47w	115	6	the	the	DT
cord-000947-psguw47w	115	7	antigen	antigen	NN
cord-000947-psguw47w	115	8	and	and	CC
cord-000947-psguw47w	115	9	the	the	DT
cord-000947-psguw47w	115	10	antibody	antibody	NN
cord-000947-psguw47w	115	11	were	be	VBD
cord-000947-psguw47w	115	12	predicted	predict	VBN
cord-000947-psguw47w	115	13	respectively	respectively	RB
cord-000947-psguw47w	115	14	.	.	.
cord-000947-psguw47w	116	1	After	after	IN
cord-000947-psguw47w	116	2	that	that	DT
cord-000947-psguw47w	116	3	the	the	DT
cord-000947-psguw47w	116	4	two	two	CD
cord-000947-psguw47w	116	5	proteins	protein	NNS
cord-000947-psguw47w	116	6	were	be	VBD
cord-000947-psguw47w	116	7	orientationally	orientationally	RB
cord-000947-psguw47w	116	8	docked	dock	VBN
cord-000947-psguw47w	116	9	according	accord	VBG
cord-000947-psguw47w	116	10	to	to	IN
cord-000947-psguw47w	116	11	the	the	DT
cord-000947-psguw47w	116	12	predicted	predict	VBN
cord-000947-psguw47w	116	13	binding	bind	VBG
cord-000947-psguw47w	116	14	sites	site	NNS
cord-000947-psguw47w	116	15	.	.	.
cord-000947-psguw47w	117	1	Sequence	sequence	NN
cord-000947-psguw47w	117	2	based	base	VBN
cord-000947-psguw47w	117	3	epitope	epitope	NN
cord-000947-psguw47w	117	4	prediction	prediction	NN
cord-000947-psguw47w	117	5	was	be	VBD
cord-000947-psguw47w	117	6	still	still	RB
cord-000947-psguw47w	117	7	difficult	difficult	JJ
cord-000947-psguw47w	117	8	especially	especially	RB
cord-000947-psguw47w	117	9	for	for	IN
cord-000947-psguw47w	117	10	the	the	DT
cord-000947-psguw47w	117	11	conformational	conformational	JJ
cord-000947-psguw47w	117	12	epitopes	epitope	NNS
cord-000947-psguw47w	117	13	.	.	.
cord-000947-psguw47w	118	1	We	-PRON-	PRP
cord-000947-psguw47w	118	2	combined	combine	VBD
cord-000947-psguw47w	118	3	the	the	DT
cord-000947-psguw47w	118	4	prediction	prediction	NN
cord-000947-psguw47w	118	5	results	result	NNS
cord-000947-psguw47w	118	6	of	of	IN
cord-000947-psguw47w	118	7	two	two	CD
cord-000947-psguw47w	118	8	different	different	JJ
cord-000947-psguw47w	118	9	software	software	NN
cord-000947-psguw47w	118	10	tools	tool	NNS
cord-000947-psguw47w	118	11	,	,	,
cord-000947-psguw47w	118	12	and	and	CC
cord-000947-psguw47w	118	13	only	only	RB
cord-000947-psguw47w	118	14	those	those	DT
cord-000947-psguw47w	118	15	epitopes	epitope	NNS
cord-000947-psguw47w	118	16	reported	report	VBN
cord-000947-psguw47w	118	17	by	by	IN
cord-000947-psguw47w	118	18	both	both	DT
cord-000947-psguw47w	118	19	methods	method	NNS
cord-000947-psguw47w	118	20	were	be	VBD
cord-000947-psguw47w	118	21	considered	consider	VBN
cord-000947-psguw47w	118	22	as	as	IN
cord-000947-psguw47w	118	23	potential	potential	JJ
cord-000947-psguw47w	118	24	epitopes	epitope	NNS
cord-000947-psguw47w	118	25	.	.	.
cord-000947-psguw47w	119	1	The	the	DT
cord-000947-psguw47w	119	2	accuracy	accuracy	NN
cord-000947-psguw47w	119	3	of	of	IN
cord-000947-psguw47w	119	4	each	each	DT
cord-000947-psguw47w	119	5	method	method	NN
cord-000947-psguw47w	119	6	was	be	VBD
cord-000947-psguw47w	119	7	73	73	CD
cord-000947-psguw47w	119	8	%	%	NN
cord-000947-psguw47w	119	9	(	(	-LRB-
cord-000947-psguw47w	119	10	FBCPred	FBCPred	NNP
cord-000947-psguw47w	119	11	)	)	-RRB-
cord-000947-psguw47w	119	12	and	and	CC
cord-000947-psguw47w	119	13	84	84	CD
cord-000947-psguw47w	119	14	%	%	NN
cord-000947-psguw47w	119	15	(	(	-LRB-
cord-000947-psguw47w	119	16	Ellipro	Ellipro	NNP
cord-000947-psguw47w	119	17	)	)	-RRB-
cord-000947-psguw47w	119	18	respectively	respectively	RB
cord-000947-psguw47w	119	19	,	,	,
cord-000947-psguw47w	119	20	so	so	CC
cord-000947-psguw47w	119	21	the	the	DT
cord-000947-psguw47w	119	22	accuracy	accuracy	NN
cord-000947-psguw47w	119	23	of	of	IN
cord-000947-psguw47w	119	24	the	the	DT
cord-000947-psguw47w	119	25	prediction	prediction	NN
cord-000947-psguw47w	119	26	of	of	IN
cord-000947-psguw47w	119	27	the	the	DT
cord-000947-psguw47w	119	28	two	two	CD
cord-000947-psguw47w	119	29	methods	method	NNS
cord-000947-psguw47w	119	30	combined	combine	VBN
cord-000947-psguw47w	119	31	could	could	MD
cord-000947-psguw47w	119	32	reach	reach	VB
cord-000947-psguw47w	119	33	95	95	CD
cord-000947-psguw47w	119	34	%	%	NN
cord-000947-psguw47w	119	35	.	.	.
cord-000947-psguw47w	120	1	The	the	DT
cord-000947-psguw47w	120	2	number	number	NN
cord-000947-psguw47w	120	3	of	of	IN
cord-000947-psguw47w	120	4	predicted	predict	VBN
cord-000947-psguw47w	120	5	epitopes	epitope	NNS
cord-000947-psguw47w	120	6	was	be	VBD
cord-000947-psguw47w	120	7	further	further	RB
cord-000947-psguw47w	120	8	reduced	reduce	VBN
cord-000947-psguw47w	120	9	by	by	IN
cord-000947-psguw47w	120	10	comparing	compare	VBG
cord-000947-psguw47w	120	11	them	-PRON-	PRP
cord-000947-psguw47w	120	12	with	with	IN
cord-000947-psguw47w	120	13	the	the	DT
cord-000947-psguw47w	120	14	peptide	peptide	NN
cord-000947-psguw47w	120	15	array	array	NN
cord-000947-psguw47w	120	16	membrane	membrane	NN
cord-000947-psguw47w	120	17	experiment	experiment	NN
cord-000947-psguw47w	120	18	results	result	NNS
cord-000947-psguw47w	120	19	.	.	.
cord-000947-psguw47w	121	1	The	the	DT
cord-000947-psguw47w	121	2	epitopes	epitope	NNS
cord-000947-psguw47w	121	3	we	-PRON-	PRP
cord-000947-psguw47w	121	4	studied	study	VBD
cord-000947-psguw47w	121	5	were	be	VBD
cord-000947-psguw47w	121	6	linear	linear	JJ
cord-000947-psguw47w	121	7	epitopes	epitope	NNS
cord-000947-psguw47w	121	8	,	,	,
cord-000947-psguw47w	121	9	and	and	CC
cord-000947-psguw47w	121	10	for	for	IN
cord-000947-psguw47w	121	11	linear	linear	JJ
cord-000947-psguw47w	121	12	peptide	peptide	NN
cord-000947-psguw47w	121	13	epitopes	epitope	NNS
cord-000947-psguw47w	121	14	,	,	,
cord-000947-psguw47w	121	15	the	the	DT
cord-000947-psguw47w	121	16	binding	binding	NN
cord-000947-psguw47w	121	17	solely	solely	RB
cord-000947-psguw47w	121	18	depends	depend	VBZ
cord-000947-psguw47w	121	19	on	on	IN
cord-000947-psguw47w	121	20	amino	amino	NN
cord-000947-psguw47w	121	21	acid	acid	NN
cord-000947-psguw47w	121	22	sequences	sequence	NNS
cord-000947-psguw47w	121	23	.	.	.
cord-000947-psguw47w	122	1	If	if	IN
cord-000947-psguw47w	122	2	an	an	DT
cord-000947-psguw47w	122	3	antibody	antibody	NN
cord-000947-psguw47w	122	4	could	could	MD
cord-000947-psguw47w	122	5	bind	bind	VB
cord-000947-psguw47w	122	6	to	to	IN
cord-000947-psguw47w	122	7	a	a	DT
cord-000947-psguw47w	122	8	linear	linear	JJ
cord-000947-psguw47w	122	9	peptide	peptide	NN
cord-000947-psguw47w	122	10	epitope	epitope	NN
cord-000947-psguw47w	122	11	,	,	,
cord-000947-psguw47w	122	12	it	-PRON-	PRP
cord-000947-psguw47w	122	13	will	will	MD
cord-000947-psguw47w	122	14	bind	bind	VB
cord-000947-psguw47w	122	15	to	to	IN
cord-000947-psguw47w	122	16	the	the	DT
cord-000947-psguw47w	122	17	peptide	peptide	NN
cord-000947-psguw47w	122	18	irrespective	irrespective	RB
cord-000947-psguw47w	122	19	of	of	IN
cord-000947-psguw47w	122	20	whether	whether	IN
cord-000947-psguw47w	122	21	the	the	DT
cord-000947-psguw47w	122	22	peptide	peptide	NN
cord-000947-psguw47w	122	23	was	be	VBD
cord-000947-psguw47w	122	24	on	on	IN
cord-000947-psguw47w	122	25	the	the	DT
cord-000947-psguw47w	122	26	protein	protein	NN
cord-000947-psguw47w	122	27	,	,	,
cord-000947-psguw47w	122	28	on	on	IN
cord-000947-psguw47w	122	29	the	the	DT
cord-000947-psguw47w	122	30	folding	folding	NN
cord-000947-psguw47w	122	31	intermediate	intermediate	JJ
cord-000947-psguw47w	122	32	or	or	CC
cord-000947-psguw47w	122	33	on	on	IN
cord-000947-psguw47w	122	34	the	the	DT
cord-000947-psguw47w	122	35	membrane	membrane	NN
cord-000947-psguw47w	122	36	.	.	.
cord-000947-psguw47w	123	1	Consequently	consequently	RB
cord-000947-psguw47w	123	2	only	only	RB
cord-000947-psguw47w	123	3	the	the	DT
cord-000947-psguw47w	123	4	epitopes	epitope	NNS
cord-000947-psguw47w	123	5	which	which	WDT
cord-000947-psguw47w	123	6	were	be	VBD
cord-000947-psguw47w	123	7	positive	positive	JJ
cord-000947-psguw47w	123	8	in	in	IN
cord-000947-psguw47w	123	9	peptide	peptide	JJ
cord-000947-psguw47w	123	10	array	array	NN
cord-000947-psguw47w	123	11	membrane	membrane	NN
cord-000947-psguw47w	123	12	experiment	experiment	NN
cord-000947-psguw47w	123	13	were	be	VBD
cord-000947-psguw47w	123	14	selected	select	VBN
cord-000947-psguw47w	123	15	for	for	IN
cord-000947-psguw47w	123	16	further	further	JJ
cord-000947-psguw47w	123	17	modeling	modeling	NN
cord-000947-psguw47w	123	18	.	.	.
cord-000947-psguw47w	124	1	Two	two	CD
cord-000947-psguw47w	124	2	antigenantibody	antigenantibody	NN
cord-000947-psguw47w	124	3	model	model	NN
cord-000947-psguw47w	124	4	complexes	complex	NNS
cord-000947-psguw47w	124	5	were	be	VBD
cord-000947-psguw47w	124	6	screened	screen	VBN
cord-000947-psguw47w	124	7	out	out	RP
cord-000947-psguw47w	124	8	as	as	IN
cord-000947-psguw47w	124	9	the	the	DT
cord-000947-psguw47w	124	10	final	final	JJ
cord-000947-psguw47w	124	11	result	result	NN
cord-000947-psguw47w	124	12	.	.	.
cord-000947-psguw47w	125	1	There	there	EX
cord-000947-psguw47w	125	2	are	be	VBP
cord-000947-psguw47w	125	3	two	two	CD
cord-000947-psguw47w	125	4	major	major	JJ
cord-000947-psguw47w	125	5	entry	entry	NN
cord-000947-psguw47w	125	6	points	point	NNS
cord-000947-psguw47w	125	7	for	for	IN
cord-000947-psguw47w	125	8	scFv	scFv	NNP
cord-000947-psguw47w	125	9	-	-	HYPH
cord-000947-psguw47w	125	10	A4	A4	NNP
cord-000947-psguw47w	125	11	to	to	TO
cord-000947-psguw47w	125	12	exert	exert	VB
cord-000947-psguw47w	125	13	its	-PRON-	PRP$
cord-000947-psguw47w	125	14	chaperone	chaperone	NN
cord-000947-psguw47w	125	15	-	-	HYPH
cord-000947-psguw47w	125	16	like	like	JJ
cord-000947-psguw47w	125	17	function	function	NN
cord-000947-psguw47w	125	18	on	on	IN
cord-000947-psguw47w	125	19	HCK	HCK	NNP
cord-000947-psguw47w	125	20	,	,	,
cord-000947-psguw47w	125	21	on	on	IN
cord-000947-psguw47w	125	22	the	the	DT
cord-000947-psguw47w	125	23	HCK	HCK	NNP
cord-000947-psguw47w	125	24	folding	fold	VBG
cord-000947-psguw47w	125	25	intermediate	intermediate	JJ
cord-000947-psguw47w	125	26	or	or	CC
cord-000947-psguw47w	125	27	on	on	IN
cord-000947-psguw47w	125	28	the	the	DT
cord-000947-psguw47w	125	29	folded	fold	VBN
cord-000947-psguw47w	125	30	HCK	HCK	NNP
cord-000947-psguw47w	125	31	.	.	.
cord-000947-psguw47w	126	1	Yan	Yan	NNP
cord-000947-psguw47w	126	2	et	et	NNP
cord-000947-psguw47w	126	3	al	al	NNP
cord-000947-psguw47w	126	4	found	find	VBD
cord-000947-psguw47w	126	5	that	that	IN
cord-000947-psguw47w	126	6	the	the	DT
cord-000947-psguw47w	126	7	C	C	NNP
cord-000947-psguw47w	126	8	-	-	HYPH
cord-000947-psguw47w	126	9	terminal	terminal	NN
cord-000947-psguw47w	126	10	domain	domain	NN
cord-000947-psguw47w	126	11	of	of	IN
cord-000947-psguw47w	126	12	HCK	HCK	NNP
cord-000947-psguw47w	126	13	was	be	VBD
cord-000947-psguw47w	126	14	more	more	RBR
cord-000947-psguw47w	126	15	likely	likely	JJ
cord-000947-psguw47w	126	16	to	to	TO
cord-000947-psguw47w	126	17	be	be	VB
cord-000947-psguw47w	126	18	the	the	DT
cord-000947-psguw47w	126	19	binding	binding	NN
cord-000947-psguw47w	126	20	site	site	NN
cord-000947-psguw47w	126	21	during	during	IN
cord-000947-psguw47w	126	22	rabbit	rabbit	NN
cord-000947-psguw47w	126	23	muscle	muscle	NN
cord-000947-psguw47w	126	24	CK	CK	NNP
cord-000947-psguw47w	126	25	(	(	-LRB-
cord-000947-psguw47w	126	26	RMCK	RMCK	NNP
cord-000947-psguw47w	126	27	)	)	-RRB-
cord-000947-psguw47w	126	28	aggregation	aggregation	NN
cord-000947-psguw47w	126	29	[	[	-LRB-
cord-000947-psguw47w	126	30	33	33	CD
cord-000947-psguw47w	126	31	]	]	-RRB-
cord-000947-psguw47w	127	1	and	and	CC
cord-000947-psguw47w	127	2	the	the	DT
cord-000947-psguw47w	127	3	linker	linker	NN
cord-000947-psguw47w	127	4	played	play	VBD
cord-000947-psguw47w	127	5	a	a	DT
cord-000947-psguw47w	127	6	crucial	crucial	JJ
cord-000947-psguw47w	127	7	role	role	NN
cord-000947-psguw47w	127	8	in	in	IN
cord-000947-psguw47w	127	9	RMCK	RMCK	NNP
cord-000947-psguw47w	127	10	folding	fold	VBG
cord-000947-psguw47w	127	11	[	[	-LRB-
cord-000947-psguw47w	127	12	34	34	CD
cord-000947-psguw47w	127	13	,	,	,
cord-000947-psguw47w	127	14	35	35	CD
cord-000947-psguw47w	127	15	]	]	-RRB-
cord-000947-psguw47w	127	16	.	.	.
cord-000947-psguw47w	128	1	After	after	IN
cord-000947-psguw47w	128	2	further	further	RB
cord-000947-psguw47w	128	3	investigate	investigate	VB
cord-000947-psguw47w	128	4	,	,	,
cord-000947-psguw47w	128	5	they	-PRON-	PRP
cord-000947-psguw47w	128	6	found	find	VBD
cord-000947-psguw47w	128	7	that	that	IN
cord-000947-psguw47w	128	8	the	the	DT
cord-000947-psguw47w	128	9	linker	linker	NN
cord-000947-psguw47w	128	10	act	act	NN
cord-000947-psguw47w	128	11	as	as	IN
cord-000947-psguw47w	128	12	a	a	DT
cord-000947-psguw47w	128	13	lid	lid	NN
cord-000947-psguw47w	128	14	to	to	TO
cord-000947-psguw47w	128	15	protect	protect	VB
cord-000947-psguw47w	128	16	the	the	DT
cord-000947-psguw47w	128	17	hydrophobic	hydrophobic	JJ
cord-000947-psguw47w	128	18	side	side	NN
cord-000947-psguw47w	128	19	chains	chain	NNS
cord-000947-psguw47w	128	20	of	of	IN
cord-000947-psguw47w	128	21	PHE250	PHE250	NNP
cord-000947-psguw47w	128	22	and	and	CC
cord-000947-psguw47w	128	23	VAL347	VAL347	VBG
cord-000947-psguw47w	128	24	against	against	IN
cord-000947-psguw47w	128	25	exposure	exposure	NN
cord-000947-psguw47w	128	26	to	to	IN
cord-000947-psguw47w	128	27	solvent	solvent	NN
cord-000947-psguw47w	128	28	[	[	-LRB-
cord-000947-psguw47w	128	29	36	36	CD
cord-000947-psguw47w	128	30	]	]	-RRB-
cord-000947-psguw47w	128	31	.	.	.
cord-000947-psguw47w	129	1	In	in	IN
cord-000947-psguw47w	129	2	complex	complex	JJ
cord-000947-psguw47w	129	3	model	model	NN
cord-000947-psguw47w	129	4	-	-	:
cord-000947-psguw47w	129	5	I	i	NN
cord-000947-psguw47w	129	6	,	,	,
cord-000947-psguw47w	129	7	scFv	scFv	NNP
cord-000947-psguw47w	129	8	-	-	HYPH
cord-000947-psguw47w	129	9	A4	A4	NNP
cord-000947-psguw47w	129	10	bound	bind	VBN
cord-000947-psguw47w	129	11	to	to	IN
cord-000947-psguw47w	129	12	the	the	DT
cord-000947-psguw47w	129	13	opposite	opposite	JJ
cord-000947-psguw47w	129	14	site	site	NN
cord-000947-psguw47w	129	15	of	of	IN
cord-000947-psguw47w	129	16	HCK	HCK	NNP
cord-000947-psguw47w	129	17	thus	thus	RB
cord-000947-psguw47w	129	18	has	have	VBZ
cord-000947-psguw47w	129	19	not	not	RB
cord-000947-psguw47w	129	20	impact	impact	NN
cord-000947-psguw47w	129	21	on	on	IN
cord-000947-psguw47w	129	22	these	these	DT
cord-000947-psguw47w	129	23	residues	residue	NNS
cord-000947-psguw47w	129	24	(	(	-LRB-
cord-000947-psguw47w	129	25	Figure	figure	NN
cord-000947-psguw47w	129	26	5a	5a	CD
cord-000947-psguw47w	129	27	)	)	-RRB-
cord-000947-psguw47w	129	28	.	.	.
cord-000947-psguw47w	130	1	In	in	IN
cord-000947-psguw47w	130	2	complex	complex	JJ
cord-000947-psguw47w	130	3	model	model	NN
cord-000947-psguw47w	130	4	-	-	HYPH
cord-000947-psguw47w	130	5	II	II	NNP
cord-000947-psguw47w	130	6	,	,	,
cord-000947-psguw47w	130	7	the	the	DT
cord-000947-psguw47w	130	8	binding	binding	JJ
cord-000947-psguw47w	130	9	position	position	NN
cord-000947-psguw47w	130	10	of	of	IN
cord-000947-psguw47w	130	11	scFV	scFV	NNP
cord-000947-psguw47w	130	12	-	-	HYPH
cord-000947-psguw47w	130	13	A4	A4	NNP
cord-000947-psguw47w	130	14	was	be	VBD
cord-000947-psguw47w	130	15	close	close	JJ
cord-000947-psguw47w	130	16	to	to	IN
cord-000947-psguw47w	130	17	the	the	DT
cord-000947-psguw47w	130	18	two	two	CD
cord-000947-psguw47w	130	19	hydrophobic	hydrophobic	JJ
cord-000947-psguw47w	130	20	residues	residue	NNS
cord-000947-psguw47w	130	21	and	and	CC
cord-000947-psguw47w	130	22	actually	actually	RB
cord-000947-psguw47w	130	23	formed	form	VBD
cord-000947-psguw47w	130	24	a	a	DT
cord-000947-psguw47w	130	25	bulky	bulky	JJ
cord-000947-psguw47w	130	26	protrusion	protrusion	NN
cord-000947-psguw47w	130	27	(	(	-LRB-
cord-000947-psguw47w	130	28	Figure	figure	NN
cord-000947-psguw47w	130	29	5b	5b	CD
cord-000947-psguw47w	130	30	)	)	-RRB-
cord-000947-psguw47w	130	31	,	,	,
cord-000947-psguw47w	130	32	therefore	therefore	RB
cord-000947-psguw47w	130	33	for	for	IN
cord-000947-psguw47w	130	34	complex	complex	JJ
cord-000947-psguw47w	130	35	model	model	NN
cord-000947-psguw47w	130	36	-	-	HYPH
cord-000947-psguw47w	130	37	II	II	NNP
cord-000947-psguw47w	130	38	,	,	,
cord-000947-psguw47w	130	39	scFv	scFv	NNP
cord-000947-psguw47w	130	40	-	-	HYPH
cord-000947-psguw47w	130	41	A4	a4	NN
cord-000947-psguw47w	130	42	bound	bind	VBN
cord-000947-psguw47w	130	43	to	to	IN
cord-000947-psguw47w	130	44	HCK	HCK	NNP
cord-000947-psguw47w	130	45	would	would	MD
cord-000947-psguw47w	130	46	hinder	hinder	VB
cord-000947-psguw47w	130	47	the	the	DT
cord-000947-psguw47w	130	48	aggregation	aggregation	NN
cord-000947-psguw47w	130	49	of	of	IN
cord-000947-psguw47w	130	50	HCK	HCK	NNP
cord-000947-psguw47w	130	51	by	by	IN
cord-000947-psguw47w	130	52	steric	steric	JJ
cord-000947-psguw47w	130	53	effects	effect	NNS
cord-000947-psguw47w	130	54	.	.	.
cord-000947-psguw47w	131	1	Webb	Webb	NNP
cord-000947-psguw47w	131	2	[	[	-LRB-
cord-000947-psguw47w	131	3	37	37	CD
cord-000947-psguw47w	131	4	]	]	-RRB-
cord-000947-psguw47w	131	5	found	find	VBD
cord-000947-psguw47w	131	6	that	that	IN
cord-000947-psguw47w	131	7	the	the	DT
cord-000947-psguw47w	131	8	C	C	NNP
cord-000947-psguw47w	131	9	-	-	HYPH
cord-000947-psguw47w	131	10	terminal	terminal	NN
cord-000947-psguw47w	131	11	portion	portion	NN
cord-000947-psguw47w	131	12	of	of	IN
cord-000947-psguw47w	131	13	the	the	DT
cord-000947-psguw47w	131	14	chick	chick	NN
cord-000947-psguw47w	131	15	CK	CK	NNP
cord-000947-psguw47w	131	16	(	(	-LRB-
cord-000947-psguw47w	131	17	GLY215	GLY215	VBG
cord-000947-psguw47w	131	18	to	to	IN
cord-000947-psguw47w	131	19	LYS380	LYS380	NNP
cord-000947-psguw47w	131	20	)	)	-RRB-
cord-000947-psguw47w	131	21	was	be	VBD
cord-000947-psguw47w	131	22	much	much	RB
cord-000947-psguw47w	131	23	more	more	RBR
cord-000947-psguw47w	131	24	resistant	resistant	JJ
cord-000947-psguw47w	131	25	to	to	IN
cord-000947-psguw47w	131	26	digestion	digestion	NN
cord-000947-psguw47w	131	27	than	than	IN
cord-000947-psguw47w	131	28	the	the	DT
cord-000947-psguw47w	131	29	N	n	CD
cord-000947-psguw47w	131	30	-	-	HYPH
cord-000947-psguw47w	131	31	terminal	terminal	NN
cord-000947-psguw47w	131	32	portion	portion	NN
cord-000947-psguw47w	131	33	(	(	-LRB-
cord-000947-psguw47w	131	34	PRO1	pro1	RB
cord-000947-psguw47w	131	35	to	to	IN
cord-000947-psguw47w	131	36	GLY133	GLY133	NNP
cord-000947-psguw47w	131	37	)	)	-RRB-
cord-000947-psguw47w	131	38	,	,	,
cord-000947-psguw47w	131	39	and	and	CC
cord-000947-psguw47w	131	40	the	the	DT
cord-000947-psguw47w	131	41	middle	middle	NN
cord-000947-psguw47w	131	42	of	of	IN
cord-000947-psguw47w	131	43	the	the	DT
cord-000947-psguw47w	131	44	HCK	HCK	NNP
cord-000947-psguw47w	131	45	sequence	sequence	NN
cord-000947-psguw47w	131	46	(	(	-LRB-
cord-000947-psguw47w	131	47	ARG134	ARG134	VBN
cord-000947-psguw47w	131	48	to	to	IN
cord-000947-psguw47w	131	49	ARG214	ARG214	NNP
cord-000947-psguw47w	131	50	)	)	-RRB-
cord-000947-psguw47w	131	51	was	be	VBD
cord-000947-psguw47w	131	52	most	most	RBS
cord-000947-psguw47w	131	53	sensitive	sensitive	JJ
cord-000947-psguw47w	131	54	to	to	IN
cord-000947-psguw47w	131	55	proteolysis	proteolysis	NN
cord-000947-psguw47w	131	56	.	.	.
cord-000947-psguw47w	132	1	They	-PRON-	PRP
cord-000947-psguw47w	132	2	proposed	propose	VBD
cord-000947-psguw47w	132	3	that	that	IN
cord-000947-psguw47w	132	4	the	the	DT
cord-000947-psguw47w	132	5	folding	fold	VBG
cord-000947-psguw47w	132	6	intermediate	intermediate	JJ
cord-000947-psguw47w	132	7	consisted	consist	VBD
cord-000947-psguw47w	132	8	of	of	IN
cord-000947-psguw47w	132	9	a	a	DT
cord-000947-psguw47w	132	10	folded	fold	VBN
cord-000947-psguw47w	132	11	C	c	NN
cord-000947-psguw47w	132	12	-	-	HYPH
cord-000947-psguw47w	132	13	terminal	terminal	NN
cord-000947-psguw47w	132	14	domain	domain	NN
cord-000947-psguw47w	132	15	and	and	CC
cord-000947-psguw47w	132	16	a	a	DT
cord-000947-psguw47w	132	17	partially	partially	RB
cord-000947-psguw47w	132	18	folded	fold	VBN
cord-000947-psguw47w	132	19	N	n	CD
cord-000947-psguw47w	132	20	-	-	HYPH
cord-000947-psguw47w	132	21	terminal	terminal	NN
cord-000947-psguw47w	132	22	domain	domain	NN
cord-000947-psguw47w	132	23	separated	separate	VBN
cord-000947-psguw47w	132	24	by	by	IN
cord-000947-psguw47w	132	25	an	an	DT
cord-000947-psguw47w	132	26	unfolded	unfold	VBN
cord-000947-psguw47w	132	27	central	central	JJ
cord-000947-psguw47w	132	28	linker	linker	NN
cord-000947-psguw47w	132	29	.	.	.
cord-000947-psguw47w	133	1	Gross	Gross	NNP
cord-000947-psguw47w	133	2	et	et	FW
cord-000947-psguw47w	133	3	al	al	NNP
cord-000947-psguw47w	133	4	.	.	NNP
cord-000947-psguw47w	133	5	's	's	POS
cord-000947-psguw47w	133	6	studies	study	NNS
cord-000947-psguw47w	133	7	suggested	suggest	VBD
cord-000947-psguw47w	133	8	that	that	IN
cord-000947-psguw47w	133	9	the	the	DT
cord-000947-psguw47w	133	10	C	C	NNP
cord-000947-psguw47w	133	11	-	-	HYPH
cord-000947-psguw47w	133	12	terminal	terminal	NN
cord-000947-psguw47w	133	13	fragment	fragment	NN
cord-000947-psguw47w	133	14	(	(	-LRB-
cord-000947-psguw47w	133	15	168	168	CD
cord-000947-psguw47w	133	16	-	-	SYM
cord-000947-psguw47w	133	17	380	380	CD
cord-000947-psguw47w	133	18	)	)	-RRB-
cord-000947-psguw47w	133	19	of	of	IN
cord-000947-psguw47w	133	20	mitochondrial	mitochondrial	NN
cord-000947-psguw47w	133	21	CK	CK	NNP
cord-000947-psguw47w	133	22	represented	represent	VBD
cord-000947-psguw47w	133	23	an	an	DT
cord-000947-psguw47w	133	24	autonomous	autonomous	JJ
cord-000947-psguw47w	133	25	folding	folding	NN
cord-000947-psguw47w	133	26	unit	unit	NN
cord-000947-psguw47w	133	27	,	,	,
cord-000947-psguw47w	133	28	and	and	CC
cord-000947-psguw47w	133	29	that	that	IN
cord-000947-psguw47w	133	30	the	the	DT
cord-000947-psguw47w	133	31	folding	folding	NN
cord-000947-psguw47w	133	32	of	of	IN
cord-000947-psguw47w	133	33	the	the	DT
cord-000947-psguw47w	133	34	C	C	NNP
cord-000947-psguw47w	133	35	-	-	HYPH
cord-000947-psguw47w	133	36	terminal	terminal	NN
cord-000947-psguw47w	133	37	domain	domain	NN
cord-000947-psguw47w	133	38	might	may	MD
cord-000947-psguw47w	133	39	precede	precede	VB
cord-000947-psguw47w	133	40	the	the	DT
cord-000947-psguw47w	133	41	conformational	conformational	JJ
cord-000947-psguw47w	133	42	stabilization	stabilization	NN
cord-000947-psguw47w	133	43	of	of	IN
cord-000947-psguw47w	133	44	the	the	DT
cord-000947-psguw47w	133	45	N	n	CD
cord-000947-psguw47w	133	46	-	-	HYPH
cord-000947-psguw47w	133	47	terminal	terminal	NN
cord-000947-psguw47w	133	48	moiety	moiety	NN
cord-000947-psguw47w	133	49	in	in	IN
cord-000947-psguw47w	133	50	vivo	vivo	NNP
cord-000947-psguw47w	133	51	[	[	-LRB-
cord-000947-psguw47w	133	52	38	38	CD
cord-000947-psguw47w	133	53	]	]	-RRB-
cord-000947-psguw47w	133	54	.	.	.
cord-000947-psguw47w	134	1	The	the	DT
cord-000947-psguw47w	134	2	binding	binding	NN
cord-000947-psguw47w	134	3	site	site	NN
cord-000947-psguw47w	134	4	of	of	IN
cord-000947-psguw47w	134	5	complex	complex	JJ
cord-000947-psguw47w	134	6	model	model	NN
cord-000947-psguw47w	134	7	-	-	:
cord-000947-psguw47w	134	8	I	-PRON-	PRP
cord-000947-psguw47w	134	9	was	be	VBD
cord-000947-psguw47w	134	10	located	locate	VBN
cord-000947-psguw47w	134	11	between	between	IN
cord-000947-psguw47w	134	12	these	these	DT
cord-000947-psguw47w	134	13	two	two	CD
cord-000947-psguw47w	134	14	terminal	terminal	NN
cord-000947-psguw47w	134	15	domains	domain	NNS
cord-000947-psguw47w	134	16	,	,	,
cord-000947-psguw47w	134	17	which	which	WDT
cord-000947-psguw47w	134	18	indicated	indicate	VBD
cord-000947-psguw47w	134	19	that	that	IN
cord-000947-psguw47w	134	20	in	in	IN
cord-000947-psguw47w	134	21	complex	complex	JJ
cord-000947-psguw47w	134	22	model	model	NN
cord-000947-psguw47w	134	23	-	-	:
cord-000947-psguw47w	134	24	I	i	NN
cord-000947-psguw47w	134	25	,	,	,
cord-000947-psguw47w	134	26	scFv	scFv	NNP
cord-000947-psguw47w	134	27	-	-	HYPH
cord-000947-psguw47w	134	28	A4	A4	NNP
cord-000947-psguw47w	134	29	would	would	MD
cord-000947-psguw47w	134	30	not	not	RB
cord-000947-psguw47w	134	31	significantly	significantly	RB
cord-000947-psguw47w	134	32	interfere	interfere	VB
cord-000947-psguw47w	134	33	with	with	IN
cord-000947-psguw47w	134	34	the	the	DT
cord-000947-psguw47w	134	35	major	major	JJ
cord-000947-psguw47w	134	36	folding	folding	NN
cord-000947-psguw47w	134	37	path	path	NN
cord-000947-psguw47w	134	38	ways	way	NNS
cord-000947-psguw47w	134	39	of	of	IN
cord-000947-psguw47w	134	40	the	the	DT
cord-000947-psguw47w	134	41	two	two	CD
cord-000947-psguw47w	134	42	domains	domain	NNS
cord-000947-psguw47w	134	43	.	.	.
cord-000947-psguw47w	135	1	It	-PRON-	PRP
cord-000947-psguw47w	135	2	may	may	MD
cord-000947-psguw47w	135	3	stabilize	stabilize	VB
cord-000947-psguw47w	135	4	the	the	DT
cord-000947-psguw47w	135	5	folded	fold	VBN
cord-000947-psguw47w	135	6	C	c	NN
cord-000947-psguw47w	135	7	-	-	HYPH
cord-000947-psguw47w	135	8	terminal	terminal	NN
cord-000947-psguw47w	135	9	domain	domain	NN
cord-000947-psguw47w	135	10	and	and	CC
cord-000947-psguw47w	135	11	assist	assist	VB
cord-000947-psguw47w	135	12	in	in	IN
cord-000947-psguw47w	135	13	the	the	DT
cord-000947-psguw47w	135	14	folding	folding	NN
cord-000947-psguw47w	135	15	of	of	IN
cord-000947-psguw47w	135	16	the	the	DT
cord-000947-psguw47w	135	17	Nterminal	Nterminal	NNP
cord-000947-psguw47w	135	18	domain	domain	NN
cord-000947-psguw47w	135	19	.	.	.
cord-000947-psguw47w	136	1	There	there	EX
cord-000947-psguw47w	136	2	was	be	VBD
cord-000947-psguw47w	136	3	a	a	DT
cord-000947-psguw47w	136	4	V8	V8	NNP
cord-000947-psguw47w	136	5	endoproteinase	endoproteinase	NN
cord-000947-psguw47w	136	6	sensitive	sensitive	JJ
cord-000947-psguw47w	136	7	fragment	fragment	NN
cord-000947-psguw47w	136	8	in	in	IN
cord-000947-psguw47w	136	9	the	the	DT
cord-000947-psguw47w	136	10	chick	chick	NN
cord-000947-psguw47w	136	11	CK	CK	NNP
cord-000947-psguw47w	136	12	intermediate	intermediate	JJ
cord-000947-psguw47w	136	13	.	.	.
cord-000947-psguw47w	137	1	When	when	WRB
cord-000947-psguw47w	137	2	the	the	DT
cord-000947-psguw47w	137	3	chick	chick	NN
cord-000947-psguw47w	137	4	CK	CK	NNP
cord-000947-psguw47w	137	5	had	have	VBD
cord-000947-psguw47w	137	6	been	be	VBN
cord-000947-psguw47w	137	7	resurrected	resurrect	VBN
cord-000947-psguw47w	137	8	,	,	,
cord-000947-psguw47w	137	9	this	this	DT
cord-000947-psguw47w	137	10	fragment	fragment	NN
cord-000947-psguw47w	137	11	resisted	resist	VBD
cord-000947-psguw47w	137	12	to	to	IN
cord-000947-psguw47w	137	13	the	the	DT
cord-000947-psguw47w	137	14	proteinase	proteinase	NN
cord-000947-psguw47w	137	15	,	,	,
cord-000947-psguw47w	137	16	since	since	IN
cord-000947-psguw47w	137	17	it	-PRON-	PRP
cord-000947-psguw47w	137	18	became	become	VBD
cord-000947-psguw47w	137	19	less	less	RBR
cord-000947-psguw47w	137	20	exposed	expose	VBN
cord-000947-psguw47w	137	21	in	in	IN
cord-000947-psguw47w	137	22	the	the	DT
cord-000947-psguw47w	137	23	folded	folded	JJ
cord-000947-psguw47w	137	24	kinase	kinase	NN
cord-000947-psguw47w	137	25	[	[	-LRB-
cord-000947-psguw47w	137	26	39	39	CD
cord-000947-psguw47w	137	27	]	]	-RRB-
cord-000947-psguw47w	137	28	.	.	.
cord-000947-psguw47w	138	1	Therefore	therefore	RB
cord-000947-psguw47w	138	2	,	,	,
cord-000947-psguw47w	138	3	this	this	DT
cord-000947-psguw47w	138	4	fragment	fragment	NN
cord-000947-psguw47w	138	5	can	can	MD
cord-000947-psguw47w	138	6	be	be	VB
cord-000947-psguw47w	138	7	regarded	regard	VBN
cord-000947-psguw47w	138	8	as	as	IN
cord-000947-psguw47w	138	9	a	a	DT
cord-000947-psguw47w	138	10	characteristic	characteristic	JJ
cord-000947-psguw47w	138	11	part	part	NN
cord-000947-psguw47w	138	12	of	of	IN
cord-000947-psguw47w	138	13	the	the	DT
cord-000947-psguw47w	138	14	creatine	creatine	NN
cord-000947-psguw47w	138	15	kinase	kinase	NN
cord-000947-psguw47w	138	16	intermediate	intermediate	JJ
cord-000947-psguw47w	138	17	.	.	.
cord-000947-psguw47w	139	1	This	this	DT
cord-000947-psguw47w	139	2	fragment	fragment	NN
cord-000947-psguw47w	139	3	identified	identify	VBN
cord-000947-psguw47w	139	4	by	by	IN
cord-000947-psguw47w	139	5	V8	V8	NNP
cord-000947-psguw47w	139	6	endoproteinase	endoproteinase	NN
cord-000947-psguw47w	139	7	was	be	VBD
cord-000947-psguw47w	139	8	IFKKAG	IFKKAG	NNP
cord-000947-psguw47w	139	9	[	[	-LRB-
cord-000947-psguw47w	139	10	37	37	CD
cord-000947-psguw47w	139	11	]	]	-RRB-
cord-000947-psguw47w	139	12	,	,	.
cord-000947-psguw47w	140	1	the	the	DT
cord-000947-psguw47w	140	2	corresponding	corresponding	JJ
cord-000947-psguw47w	140	3	sequence	sequence	NN
cord-000947-psguw47w	140	4	of	of	IN
cord-000947-psguw47w	140	5	HCK	HCK	NNP
cord-000947-psguw47w	140	6	was	be	VBD
cord-000947-psguw47w	140	7	ILE263-GLY268	ile263-gly268	JJ
cord-000947-psguw47w	140	8	.	.	.
cord-000947-psguw47w	141	1	It	-PRON-	PRP
cord-000947-psguw47w	141	2	is	be	VBZ
cord-000947-psguw47w	141	3	interesting	interesting	JJ
cord-000947-psguw47w	141	4	that	that	IN
cord-000947-psguw47w	141	5	in	in	IN
cord-000947-psguw47w	141	6	complex	complex	JJ
cord-000947-psguw47w	141	7	model	model	NN
cord-000947-psguw47w	141	8	-	-	HYPH
cord-000947-psguw47w	141	9	II	II	NNP
cord-000947-psguw47w	141	10	,	,	,
cord-000947-psguw47w	141	11	scFv	scFv	NNP
cord-000947-psguw47w	141	12	-	-	HYPH
cord-000947-psguw47w	141	13	A4	A4	NNP
cord-000947-psguw47w	141	14	also	also	RB
cord-000947-psguw47w	141	15	bound	bind	VBN
cord-000947-psguw47w	141	16	to	to	IN
cord-000947-psguw47w	141	17	this	this	DT
cord-000947-psguw47w	141	18	segment	segment	NN
cord-000947-psguw47w	141	19	which	which	WDT
cord-000947-psguw47w	141	20	indicated	indicate	VBD
cord-000947-psguw47w	141	21	that	that	IN
cord-000947-psguw47w	141	22	scFv	scFv	NNP
cord-000947-psguw47w	141	23	-	-	HYPH
cord-000947-psguw47w	141	24	A4	A4	NNP
cord-000947-psguw47w	141	25	could	could	MD
cord-000947-psguw47w	141	26	bind	bind	VB
cord-000947-psguw47w	141	27	with	with	IN
cord-000947-psguw47w	141	28	the	the	DT
cord-000947-psguw47w	141	29	intermediate	intermediate	JJ
cord-000947-psguw47w	141	30	and	and	CC
cord-000947-psguw47w	141	31	participate	participate	VB
cord-000947-psguw47w	141	32	in	in	IN
cord-000947-psguw47w	141	33	HCK	HCK	NNP
cord-000947-psguw47w	141	34	folding	fold	VBG
cord-000947-psguw47w	141	35	or	or	CC
cord-000947-psguw47w	141	36	resurrecting	resurrect	VBG
cord-000947-psguw47w	141	37	process	process	NN
cord-000947-psguw47w	141	38	.	.	.
cord-000947-psguw47w	142	1	To	to	TO
cord-000947-psguw47w	142	2	summarize	summarize	VB
cord-000947-psguw47w	142	3	,	,	,
cord-000947-psguw47w	142	4	in	in	IN
cord-000947-psguw47w	142	5	complex	complex	JJ
cord-000947-psguw47w	142	6	model	model	NN
cord-000947-psguw47w	142	7	-	-	HYPH
cord-000947-psguw47w	142	8	II	II	NNP
cord-000947-psguw47w	142	9	scFv	scFv	NNP
cord-000947-psguw47w	142	10	-	-	HYPH
cord-000947-psguw47w	142	11	A4	A4	NNP
cord-000947-psguw47w	142	12	can	can	MD
cord-000947-psguw47w	142	13	exhibit	exhibit	VB
cord-000947-psguw47w	142	14	a	a	DT
cord-000947-psguw47w	142	15	chaperone	chaperone	NN
cord-000947-psguw47w	142	16	-	-	HYPH
cord-000947-psguw47w	142	17	like	like	JJ
cord-000947-psguw47w	142	18	function	function	NN
cord-000947-psguw47w	142	19	either	either	CC
cord-000947-psguw47w	142	20	by	by	IN
cord-000947-psguw47w	142	21	hindering	hinder	VBG
cord-000947-psguw47w	142	22	the	the	DT
cord-000947-psguw47w	142	23	aggregation	aggregation	NN
cord-000947-psguw47w	142	24	by	by	IN
cord-000947-psguw47w	142	25	the	the	DT
cord-000947-psguw47w	142	26	steric	steric	JJ
cord-000947-psguw47w	142	27	effects	effect	NNS
cord-000947-psguw47w	142	28	or	or	CC
cord-000947-psguw47w	142	29	by	by	IN
cord-000947-psguw47w	142	30	assisting	assist	VBG
cord-000947-psguw47w	142	31	the	the	DT
cord-000947-psguw47w	142	32	folding	folding	NN
cord-000947-psguw47w	142	33	of	of	IN
cord-000947-psguw47w	142	34	HCK	HCK	NNP
cord-000947-psguw47w	142	35	and	and	CC
cord-000947-psguw47w	142	36	stabilizing	stabilize	VBG
cord-000947-psguw47w	142	37	the	the	DT
cord-000947-psguw47w	142	38	folded	fold	VBN
cord-000947-psguw47w	142	39	conformation	conformation	NN
cord-000947-psguw47w	142	40	.	.	.
cord-000947-psguw47w	143	1	In	in	IN
cord-000947-psguw47w	143	2	complex	complex	JJ
cord-000947-psguw47w	143	3	model	model	NN
cord-000947-psguw47w	143	4	-	-	:
cord-000947-psguw47w	143	5	I	i	NN
cord-000947-psguw47w	143	6	,	,	,
cord-000947-psguw47w	143	7	scFv	scFv	NNP
cord-000947-psguw47w	143	8	-	-	HYPH
cord-000947-psguw47w	143	9	A4	A4	NNP
cord-000947-psguw47w	143	10	exhibits	exhibit	VBZ
cord-000947-psguw47w	143	11	chaperone	chaperone	NN
cord-000947-psguw47w	143	12	-	-	HYPH
cord-000947-psguw47w	143	13	like	like	JJ
cord-000947-psguw47w	143	14	function	function	NN
cord-000947-psguw47w	143	15	by	by	IN
cord-000947-psguw47w	143	16	assisting	assist	VBG
cord-000947-psguw47w	143	17	the	the	DT
cord-000947-psguw47w	143	18	folding	folding	NN
cord-000947-psguw47w	143	19	of	of	IN
cord-000947-psguw47w	143	20	HCK	HCK	NNP
cord-000947-psguw47w	143	21	and	and	CC
cord-000947-psguw47w	143	22	stabilizing	stabilize	VBG
cord-000947-psguw47w	143	23	the	the	DT
cord-000947-psguw47w	143	24	whole	whole	JJ
cord-000947-psguw47w	143	25	structure	structure	NN
cord-000947-psguw47w	143	26	.	.	.
cord-000947-psguw47w	144	1	In	in	IN
cord-000947-psguw47w	144	2	this	this	DT
cord-000947-psguw47w	144	3	study	study	NN
cord-000947-psguw47w	144	4	we	-PRON-	PRP
cord-000947-psguw47w	144	5	combined	combine	VBD
cord-000947-psguw47w	144	6	computer	computer	NN
cord-000947-psguw47w	144	7	modeling	modeling	NN
cord-000947-psguw47w	144	8	and	and	CC
cord-000947-psguw47w	144	9	the	the	DT
cord-000947-psguw47w	144	10	peptide	peptide	NN
cord-000947-psguw47w	144	11	array	array	NN
cord-000947-psguw47w	144	12	membrane	membrane	NN
cord-000947-psguw47w	144	13	method	method	NN
cord-000947-psguw47w	144	14	to	to	TO
cord-000947-psguw47w	144	15	investigate	investigate	VB
cord-000947-psguw47w	144	16	the	the	DT
cord-000947-psguw47w	144	17	interaction	interaction	NN
cord-000947-psguw47w	144	18	between	between	IN
cord-000947-psguw47w	144	19	scFv	scFv	NNP
cord-000947-psguw47w	144	20	-	-	HYPH
cord-000947-psguw47w	144	21	A4	A4	NNP
cord-000947-psguw47w	144	22	and	and	CC
cord-000947-psguw47w	144	23	HCK	HCK	NNP
cord-000947-psguw47w	144	24	.	.	.
cord-000947-psguw47w	145	1	The	the	DT
cord-000947-psguw47w	145	2	mechanisms	mechanism	NNS
cord-000947-psguw47w	145	3	underlying	underlie	VBG
cord-000947-psguw47w	145	4	scFv	scFv	NNP
cord-000947-psguw47w	145	5	-	-	HYPH
cord-000947-psguw47w	145	6	A4	A4	NNP
cord-000947-psguw47w	145	7	's	's	POS
cord-000947-psguw47w	145	8	chaperone	chaperone	NN
cord-000947-psguw47w	145	9	-	-	HYPH
cord-000947-psguw47w	145	10	like	like	JJ
cord-000947-psguw47w	145	11	function	function	NN
cord-000947-psguw47w	145	12	were	be	VBD
cord-000947-psguw47w	145	13	discussed	discuss	VBN
cord-000947-psguw47w	145	14	.	.	.
cord-000947-psguw47w	146	1	The	the	DT
cord-000947-psguw47w	146	2	traditional	traditional	JJ
cord-000947-psguw47w	146	3	method	method	NN
cord-000947-psguw47w	146	4	of	of	IN
cord-000947-psguw47w	146	5	studying	study	VBG
cord-000947-psguw47w	146	6	antigen	antigen	NN
cord-000947-psguw47w	146	7	-	-	HYPH
cord-000947-psguw47w	146	8	antibody	antibody	NN
cord-000947-psguw47w	146	9	interactions	interaction	NNS
cord-000947-psguw47w	146	10	is	be	VBZ
cord-000947-psguw47w	146	11	by	by	IN
cord-000947-psguw47w	146	12	constructing	construct	VBG
cord-000947-psguw47w	146	13	many	many	JJ
cord-000947-psguw47w	146	14	antigen	antigen	NN
cord-000947-psguw47w	146	15	mutants	mutant	NNS
cord-000947-psguw47w	146	16	and	and	CC
cord-000947-psguw47w	146	17	observing	observe	VBG
cord-000947-psguw47w	146	18	the	the	DT
cord-000947-psguw47w	146	19	changes	change	NNS
cord-000947-psguw47w	146	20	of	of	IN
cord-000947-psguw47w	146	21	the	the	DT
cord-000947-psguw47w	146	22	binding	binding	NN
cord-000947-psguw47w	146	23	activity	activity	NN
cord-000947-psguw47w	146	24	.	.	.
cord-000947-psguw47w	147	1	The	the	DT
cord-000947-psguw47w	147	2	whole	whole	JJ
cord-000947-psguw47w	147	3	process	process	NN
cord-000947-psguw47w	147	4	is	be	VBZ
cord-000947-psguw47w	147	5	tedious	tedious	JJ
cord-000947-psguw47w	147	6	and	and	CC
cord-000947-psguw47w	147	7	time	time	NN
cord-000947-psguw47w	147	8	consuming	consume	VBG
cord-000947-psguw47w	147	9	.	.	.
cord-000947-psguw47w	148	1	Epitopescanning	Epitopescanning	NNP
cord-000947-psguw47w	148	2	by	by	IN
cord-000947-psguw47w	148	3	Peptide	Peptide	NNP
cord-000947-psguw47w	148	4	array	array	NN
cord-000947-psguw47w	148	5	membrane	membrane	NN
cord-000947-psguw47w	148	6	method	method	NN
cord-000947-psguw47w	148	7	has	have	VBZ
cord-000947-psguw47w	148	8	been	be	VBN
cord-000947-psguw47w	148	9	made	make	VBN
cord-000947-psguw47w	148	10	cheap	cheap	JJ
cord-000947-psguw47w	148	11	and	and	CC
cord-000947-psguw47w	148	12	fast	fast	RB
cord-000947-psguw47w	148	13	nowadays	nowadays	RB
cord-000947-psguw47w	148	14	,	,	,
cord-000947-psguw47w	148	15	our	-PRON-	PRP$
cord-000947-psguw47w	148	16	work	work	NN
cord-000947-psguw47w	148	17	demonstrated	demonstrate	VBD
cord-000947-psguw47w	148	18	that	that	IN
cord-000947-psguw47w	148	19	the	the	DT
cord-000947-psguw47w	148	20	combination	combination	NN
cord-000947-psguw47w	148	21	of	of	IN
cord-000947-psguw47w	148	22	the	the	DT
cord-000947-psguw47w	148	23	peptide	peptide	NN
cord-000947-psguw47w	148	24	array	array	NN
cord-000947-psguw47w	148	25	membrane	membrane	NN
cord-000947-psguw47w	148	26	technique	technique	NN
cord-000947-psguw47w	148	27	with	with	IN
cord-000947-psguw47w	148	28	bioinfomatics	bioinfomatic	NNS
cord-000947-psguw47w	148	29	methods	method	NNS
cord-000947-psguw47w	148	30	could	could	MD
cord-000947-psguw47w	148	31	be	be	VB
cord-000947-psguw47w	148	32	a	a	DT
cord-000947-psguw47w	148	33	more	more	RBR
cord-000947-psguw47w	148	34	efficient	efficient	JJ
cord-000947-psguw47w	148	35	approach	approach	NN
cord-000947-psguw47w	148	36	for	for	IN
cord-000947-psguw47w	148	37	epitope	epitope	NN
cord-000947-psguw47w	148	38	mapping	mapping	NN
cord-000947-psguw47w	148	39	.	.	.
cord-000947-psguw47w	149	1	For	for	IN
cord-000947-psguw47w	149	2	the	the	DT
cord-000947-psguw47w	149	3	two	two	CD
cord-000947-psguw47w	149	4	complex	complex	JJ
cord-000947-psguw47w	149	5	models	model	NNS
cord-000947-psguw47w	149	6	we	-PRON-	PRP
cord-000947-psguw47w	149	7	proposed	propose	VBD
cord-000947-psguw47w	149	8	,	,	,
cord-000947-psguw47w	149	9	further	further	JJ
cord-000947-psguw47w	149	10	study	study	NN
cord-000947-psguw47w	149	11	can	can	MD
cord-000947-psguw47w	149	12	be	be	VB
cord-000947-psguw47w	149	13	done	do	VBN
cord-000947-psguw47w	149	14	to	to	TO
cord-000947-psguw47w	149	15	verify	verify	VB
cord-000947-psguw47w	149	16	the	the	DT
cord-000947-psguw47w	149	17	models	model	NNS
cord-000947-psguw47w	149	18	by	by	IN
cord-000947-psguw47w	149	19	engineering	engineering	NN
cord-000947-psguw47w	149	20	point	point	NN
cord-000947-psguw47w	149	21	mutants	mutant	NNS
cord-000947-psguw47w	149	22	on	on	IN
cord-000947-psguw47w	149	23	the	the	DT
cord-000947-psguw47w	149	24	predicted	predict	VBN
cord-000947-psguw47w	149	25	epitopes	epitope	NNS
cord-000947-psguw47w	149	26	of	of	IN
cord-000947-psguw47w	149	27	HCK	HCK	NNP
cord-000947-psguw47w	149	28	and	and	CC
cord-000947-psguw47w	149	29	investigating	investigate	VBG
cord-000947-psguw47w	149	30	the	the	DT
cord-000947-psguw47w	149	31	change	change	NN
cord-000947-psguw47w	149	32	of	of	IN
cord-000947-psguw47w	149	33	the	the	DT
cord-000947-psguw47w	149	34	system	system	NN
cord-000947-psguw47w	149	35	's	's	POS
cord-000947-psguw47w	149	36	behaviors	behavior	NNS
cord-000947-psguw47w	149	37	.	.	.
cord-000947-psguw47w	150	1	Homology	homology	NN
cord-000947-psguw47w	150	2	modeling	model	VBG
cord-000947-psguw47w	150	3	in	in	IN
cord-000947-psguw47w	150	4	our	-PRON-	PRP$
cord-000947-psguw47w	150	5	study	study	NN
cord-000947-psguw47w	150	6	was	be	VBD
cord-000947-psguw47w	150	7	done	do	VBN
cord-000947-psguw47w	150	8	in	in	IN
cord-000947-psguw47w	150	9	the	the	DT
cord-000947-psguw47w	150	10	following	follow	VBG
cord-000947-psguw47w	150	11	three	three	CD
cord-000947-psguw47w	150	12	steps	step	NNS
cord-000947-psguw47w	150	13	:	:	:
cord-000947-psguw47w	150	14	(	(	-LRB-
cord-000947-psguw47w	150	15	1	1	LS
cord-000947-psguw47w	150	16	)	)	-RRB-
cord-000947-psguw47w	150	17	Speculating	speculate	VBG
cord-000947-psguw47w	150	18	the	the	DT
cord-000947-psguw47w	150	19	linker	linker	NN
cord-000947-psguw47w	150	20	,	,	,
cord-000947-psguw47w	150	21	the	the	DT
cord-000947-psguw47w	150	22	light	light	NN
cord-000947-psguw47w	150	23	and	and	CC
cord-000947-psguw47w	150	24	the	the	DT
cord-000947-psguw47w	150	25	heavy	heavy	JJ
cord-000947-psguw47w	150	26	chain	chain	NN
cord-000947-psguw47w	150	27	segments	segment	NNS
cord-000947-psguw47w	150	28	of	of	IN
cord-000947-psguw47w	150	29	the	the	DT
cord-000947-psguw47w	150	30	antibody	antibody	NN
cord-000947-psguw47w	150	31	.	.	.
cord-000947-psguw47w	151	1	The	the	DT
cord-000947-psguw47w	151	2	sequence	sequence	NN
cord-000947-psguw47w	151	3	of	of	IN
cord-000947-psguw47w	151	4	scFv	scFv	NNP
cord-000947-psguw47w	151	5	-	-	HYPH
cord-000947-psguw47w	151	6	A4	A4	NNP
cord-000947-psguw47w	151	7	was	be	VBD
cord-000947-psguw47w	151	8	used	use	VBN
cord-000947-psguw47w	151	9	to	to	TO
cord-000947-psguw47w	151	10	do	do	VB
cord-000947-psguw47w	151	11	a	a	DT
cord-000947-psguw47w	151	12	BLAST	blast	NN
cord-000947-psguw47w	151	13	search	search	NN
cord-000947-psguw47w	151	14	in	in	IN
cord-000947-psguw47w	151	15	the	the	DT
cord-000947-psguw47w	151	16	Non	non	JJ
cord-000947-psguw47w	151	17	-	-	JJ
cord-000947-psguw47w	151	18	redundant	redundant	JJ
cord-000947-psguw47w	151	19	protein	protein	NN
cord-000947-psguw47w	151	20	sequences	sequence	NNS
cord-000947-psguw47w	151	21	database	database	NN
cord-000947-psguw47w	151	22	of	of	IN
cord-000947-psguw47w	151	23	NCBI	NCBI	NNP
cord-000947-psguw47w	151	24	.	.	.
cord-000947-psguw47w	152	1	A	a	DT
cord-000947-psguw47w	152	2	scFv	scfv	JJ
cord-000947-psguw47w	152	3	sequence	sequence	NN
cord-000947-psguw47w	152	4	(	(	-LRB-
cord-000947-psguw47w	152	5	ID	ID	NNP
cord-000947-psguw47w	152	6	:	:	:
cord-000947-psguw47w	152	7	ACZ28696.1	ACZ28696.1	NNP
cord-000947-psguw47w	152	8	)	)	-RRB-
cord-000947-psguw47w	153	1	[	[	-LRB-
cord-000947-psguw47w	153	2	40	40	CD
cord-000947-psguw47w	153	3	]	]	-RRB-
cord-000947-psguw47w	153	4	which	which	WDT
cord-000947-psguw47w	153	5	had	have	VBD
cord-000947-psguw47w	153	6	the	the	DT
cord-000947-psguw47w	153	7	highest	high	JJS
cord-000947-psguw47w	153	8	score	score	NN
cord-000947-psguw47w	153	9	and	and	CC
cord-000947-psguw47w	153	10	the	the	DT
cord-000947-psguw47w	153	11	lowest	low	JJS
cord-000947-psguw47w	153	12	E	e	NN
cord-000947-psguw47w	153	13	value	value	NN
cord-000947-psguw47w	153	14	was	be	VBD
cord-000947-psguw47w	153	15	picked	pick	VBN
cord-000947-psguw47w	153	16	out	out	RP
cord-000947-psguw47w	153	17	to	to	TO
cord-000947-psguw47w	153	18	be	be	VB
cord-000947-psguw47w	153	19	used	use	VBN
cord-000947-psguw47w	153	20	as	as	IN
cord-000947-psguw47w	153	21	reference	reference	NN
cord-000947-psguw47w	153	22	.	.	.
cord-000947-psguw47w	154	1	The	the	DT
cord-000947-psguw47w	154	2	sequences	sequence	NNS
cord-000947-psguw47w	154	3	of	of	IN
cord-000947-psguw47w	154	4	ACZ28696.1	ACZ28696.1	NNP
cord-000947-psguw47w	154	5	and	and	CC
cord-000947-psguw47w	154	6	scFv	scFv	NNP
cord-000947-psguw47w	154	7	-	-	HYPH
cord-000947-psguw47w	154	8	A4	A4	NNP
cord-000947-psguw47w	154	9	were	be	VBD
cord-000947-psguw47w	154	10	aligned	align	VBN
cord-000947-psguw47w	154	11	by	by	IN
cord-000947-psguw47w	154	12	Clustalx1.81	clustalx1.81	XX
cord-000947-psguw47w	154	13	[	[	-LRB-
cord-000947-psguw47w	154	14	41	41	CD
cord-000947-psguw47w	154	15	]	]	-RRB-
cord-000947-psguw47w	154	16	and	and	CC
cord-000947-psguw47w	154	17	each	each	DT
cord-000947-psguw47w	154	18	area	area	NN
cord-000947-psguw47w	154	19	of	of	IN
cord-000947-psguw47w	154	20	the	the	DT
cord-000947-psguw47w	154	21	scFv	scfv	JJ
cord-000947-psguw47w	154	22	-	-	HYPH
cord-000947-psguw47w	154	23	A4	a4	NN
cord-000947-psguw47w	154	24	sequence	sequence	NN
cord-000947-psguw47w	154	25	was	be	VBD
cord-000947-psguw47w	154	26	appointed	appoint	VBN
cord-000947-psguw47w	154	27	by	by	IN
cord-000947-psguw47w	154	28	comparing	compare	VBG
cord-000947-psguw47w	154	29	the	the	DT
cord-000947-psguw47w	154	30	sequence	sequence	NN
cord-000947-psguw47w	154	31	with	with	IN
cord-000947-psguw47w	154	32	ACZ28696.1	ACZ28696.1	NNP
cord-000947-psguw47w	154	33	.	.	.
cord-000947-psguw47w	155	1	(	(	-LRB-
cord-000947-psguw47w	155	2	2	2	LS
cord-000947-psguw47w	155	3	)	)	-RRB-
cord-000947-psguw47w	155	4	Homology	homology	NN
cord-000947-psguw47w	155	5	modeling	modeling	NN
cord-000947-psguw47w	155	6	templates	template	NNS
cord-000947-psguw47w	155	7	preparation	preparation	NN
cord-000947-psguw47w	155	8	.	.	.
cord-000947-psguw47w	156	1	Since	since	IN
cord-000947-psguw47w	156	2	linker	linker	NN
cord-000947-psguw47w	156	3	peptides	peptide	NNS
cord-000947-psguw47w	156	4	of	of	IN
cord-000947-psguw47w	156	5	the	the	DT
cord-000947-psguw47w	156	6	single	single	JJ
cord-000947-psguw47w	156	7	chain	chain	NN
cord-000947-psguw47w	156	8	antibody	antibody	NN
cord-000947-psguw47w	156	9	were	be	VBD
cord-000947-psguw47w	156	10	often	often	RB
cord-000947-psguw47w	156	11	absent	absent	JJ
cord-000947-psguw47w	156	12	in	in	IN
cord-000947-psguw47w	156	13	the	the	DT
cord-000947-psguw47w	156	14	PDB	PDB	NNP
cord-000947-psguw47w	156	15	database	database	NN
cord-000947-psguw47w	156	16	[	[	-LRB-
cord-000947-psguw47w	156	17	42	42	CD
cord-000947-psguw47w	156	18	]	]	-RRB-
cord-000947-psguw47w	156	19	,	,	,
cord-000947-psguw47w	156	20	the	the	DT
cord-000947-psguw47w	156	21	sequence	sequence	NN
cord-000947-psguw47w	156	22	of	of	IN
cord-000947-psguw47w	156	23	the	the	DT
cord-000947-psguw47w	156	24	linker	linker	NN
cord-000947-psguw47w	156	25	peptide	peptide	NN
cord-000947-psguw47w	156	26	would	would	MD
cord-000947-psguw47w	156	27	be	be	VB
cord-000947-psguw47w	156	28	excluded	exclude	VBN
cord-000947-psguw47w	156	29	when	when	WRB
cord-000947-psguw47w	156	30	aligned	align	VBN
cord-000947-psguw47w	156	31	with	with	IN
cord-000947-psguw47w	156	32	the	the	DT
cord-000947-psguw47w	156	33	template	template	NN
cord-000947-psguw47w	156	34	antibody	antibody	NN
cord-000947-psguw47w	156	35	.	.	.
cord-000947-psguw47w	157	1	The	the	DT
cord-000947-psguw47w	157	2	sequence	sequence	NN
cord-000947-psguw47w	157	3	of	of	IN
cord-000947-psguw47w	157	4	scFv	scfv	JJ
cord-000947-psguw47w	157	5	-	-	HYPH
cord-000947-psguw47w	157	6	A4	A4	NNP
cord-000947-psguw47w	157	7	without	without	IN
cord-000947-psguw47w	157	8	linker	linker	NN
cord-000947-psguw47w	157	9	was	be	VBD
cord-000947-psguw47w	157	10	used	use	VBN
cord-000947-psguw47w	157	11	to	to	TO
cord-000947-psguw47w	157	12	search	search	VB
cord-000947-psguw47w	157	13	the	the	DT
cord-000947-psguw47w	157	14	PDB	PDB	NNP
cord-000947-psguw47w	157	15	database	database	NN
cord-000947-psguw47w	157	16	.	.	.
cord-000947-psguw47w	158	1	The	the	DT
cord-000947-psguw47w	158	2	light	light	JJ
cord-000947-psguw47w	158	3	chain	chain	NN
cord-000947-psguw47w	158	4	and	and	CC
cord-000947-psguw47w	158	5	the	the	DT
cord-000947-psguw47w	158	6	heavy	heavy	JJ
cord-000947-psguw47w	158	7	chain	chain	NN
cord-000947-psguw47w	158	8	were	be	VBD
cord-000947-psguw47w	158	9	processed	process	VBN
cord-000947-psguw47w	158	10	separately	separately	RB
cord-000947-psguw47w	158	11	.	.	.
cord-000947-psguw47w	159	1	We	-PRON-	PRP
cord-000947-psguw47w	159	2	obtained	obtain	VBD
cord-000947-psguw47w	159	3	a	a	DT
cord-000947-psguw47w	159	4	template	template	NN
cord-000947-psguw47w	159	5	(	(	-LRB-
cord-000947-psguw47w	159	6	2DD8	2dd8	CD
cord-000947-psguw47w	159	7	[	[	-LRB-
cord-000947-psguw47w	159	8	43	43	CD
cord-000947-psguw47w	159	9	]	]	-RRB-
cord-000947-psguw47w	159	10	)	)	-RRB-
cord-000947-psguw47w	159	11	with	with	IN
cord-000947-psguw47w	159	12	a	a	DT
cord-000947-psguw47w	159	13	higher	high	JJR
cord-000947-psguw47w	159	14	identity	identity	NN
cord-000947-psguw47w	159	15	which	which	WDT
cord-000947-psguw47w	159	16	was	be	VBD
cord-000947-psguw47w	159	17	a	a	DT
cord-000947-psguw47w	159	18	Fab	Fab	NNP
cord-000947-psguw47w	159	19	antibody	antibody	NN
cord-000947-psguw47w	159	20	fragment	fragment	NN
cord-000947-psguw47w	159	21	.	.	.
cord-000947-psguw47w	160	1	The	the	DT
cord-000947-psguw47w	160	2	sequence	sequence	NN
cord-000947-psguw47w	160	3	identity	identity	NN
cord-000947-psguw47w	160	4	of	of	IN
cord-000947-psguw47w	160	5	the	the	DT
cord-000947-psguw47w	160	6	light	light	JJ
cord-000947-psguw47w	160	7	chain	chain	NN
cord-000947-psguw47w	160	8	of	of	IN
cord-000947-psguw47w	160	9	the	the	DT
cord-000947-psguw47w	160	10	Fab	Fab	NNP
cord-000947-psguw47w	160	11	was	be	VBD
cord-000947-psguw47w	160	12	100	100	CD
cord-000947-psguw47w	160	13	%	%	NN
cord-000947-psguw47w	160	14	,	,	,
cord-000947-psguw47w	160	15	while	while	IN
cord-000947-psguw47w	160	16	that	that	DT
cord-000947-psguw47w	160	17	of	of	IN
cord-000947-psguw47w	160	18	the	the	DT
cord-000947-psguw47w	160	19	heavy	heavy	JJ
cord-000947-psguw47w	160	20	chain	chain	NN
cord-000947-psguw47w	160	21	was	be	VBD
cord-000947-psguw47w	160	22	93	93	CD
cord-000947-psguw47w	160	23	%	%	NN
cord-000947-psguw47w	160	24	.	.	.
cord-000947-psguw47w	161	1	Both	both	DT
cord-000947-psguw47w	161	2	chains	chain	NNS
cord-000947-psguw47w	161	3	of	of	IN
cord-000947-psguw47w	161	4	the	the	DT
cord-000947-psguw47w	161	5	Fab	Fab	NNP
cord-000947-psguw47w	161	6	were	be	VBD
cord-000947-psguw47w	161	7	used	use	VBN
cord-000947-psguw47w	161	8	as	as	IN
cord-000947-psguw47w	161	9	templates	template	NNS
cord-000947-psguw47w	161	10	for	for	IN
cord-000947-psguw47w	161	11	building	build	VBG
cord-000947-psguw47w	161	12	the	the	DT
cord-000947-psguw47w	161	13	3D	3d	JJ
cord-000947-psguw47w	161	14	model	model	NN
cord-000947-psguw47w	161	15	of	of	IN
cord-000947-psguw47w	161	16	scFv	scFv	NNP
cord-000947-psguw47w	161	17	-	-	HYPH
cord-000947-psguw47w	161	18	A4	A4	NNP
cord-000947-psguw47w	161	19	by	by	IN
cord-000947-psguw47w	161	20	Modeller	Modeller	NNP
cord-000947-psguw47w	161	21	9v7	9v7	CD
cord-000947-psguw47w	161	22	[	[	-LRB-
cord-000947-psguw47w	161	23	44	44	CD
cord-000947-psguw47w	161	24	]	]	-RRB-
cord-000947-psguw47w	161	25	.	.	.
cord-000947-psguw47w	162	1	(	(	-LRB-
cord-000947-psguw47w	162	2	3	3	LS
cord-000947-psguw47w	162	3	)	)	-RRB-
cord-000947-psguw47w	162	4	Optimization	optimization	NN
cord-000947-psguw47w	162	5	of	of	IN
cord-000947-psguw47w	162	6	the	the	DT
cord-000947-psguw47w	162	7	model	model	NN
cord-000947-psguw47w	162	8	.	.	.
cord-000947-psguw47w	163	1	Since	since	IN
cord-000947-psguw47w	163	2	the	the	DT
cord-000947-psguw47w	163	3	linker	linker	NN
cord-000947-psguw47w	163	4	was	be	VBD
cord-000947-psguw47w	163	5	modeled	model	VBN
cord-000947-psguw47w	163	6	without	without	IN
cord-000947-psguw47w	163	7	an	an	DT
cord-000947-psguw47w	163	8	appropriate	appropriate	JJ
cord-000947-psguw47w	163	9	template	template	NN
cord-000947-psguw47w	163	10	,	,	,
cord-000947-psguw47w	163	11	optimization	optimization	NN
cord-000947-psguw47w	163	12	work	work	NN
cord-000947-psguw47w	163	13	was	be	VBD
cord-000947-psguw47w	163	14	focused	focus	VBN
cord-000947-psguw47w	163	15	on	on	IN
cord-000947-psguw47w	163	16	the	the	DT
cord-000947-psguw47w	163	17	linker	linker	NN
cord-000947-psguw47w	163	18	.	.	.
cord-000947-psguw47w	164	1	The	the	DT
cord-000947-psguw47w	164	2	DOPE	dope	NN
cord-000947-psguw47w	164	3	-	-	HYPH
cord-000947-psguw47w	164	4	based	base	VBN
cord-000947-psguw47w	164	5	loop	loop	NN
cord-000947-psguw47w	164	6	modeling	modeling	NN
cord-000947-psguw47w	164	7	protocol	protocol	NN
cord-000947-psguw47w	164	8	[	[	-LRB-
cord-000947-psguw47w	164	9	44	44	CD
cord-000947-psguw47w	164	10	]	]	-RRB-
cord-000947-psguw47w	164	11	was	be	VBD
cord-000947-psguw47w	164	12	used	use	VBN
cord-000947-psguw47w	164	13	to	to	TO
cord-000947-psguw47w	164	14	optimize	optimize	VB
cord-000947-psguw47w	164	15	the	the	DT
cord-000947-psguw47w	164	16	linker	linker	NN
cord-000947-psguw47w	164	17	structure	structure	NN
cord-000947-psguw47w	164	18	.	.	.
cord-000947-psguw47w	165	1	The	the	DT
cord-000947-psguw47w	165	2	CDRs	cdr	NNS
cord-000947-psguw47w	165	3	are	be	VBP
cord-000947-psguw47w	165	4	the	the	DT
cord-000947-psguw47w	165	5	major	major	JJ
cord-000947-psguw47w	165	6	region	region	NN
cord-000947-psguw47w	165	7	of	of	IN
cord-000947-psguw47w	165	8	the	the	DT
cord-000947-psguw47w	165	9	antibodies	antibody	NNS
cord-000947-psguw47w	165	10	that	that	WDT
cord-000947-psguw47w	165	11	bind	bind	VBP
cord-000947-psguw47w	165	12	to	to	IN
cord-000947-psguw47w	165	13	antigens	antigen	NNS
cord-000947-psguw47w	165	14	.	.	.
cord-000947-psguw47w	166	1	Since	since	IN
cord-000947-psguw47w	166	2	the	the	DT
cord-000947-psguw47w	166	3	CDRs	cdr	NNS
cord-000947-psguw47w	166	4	of	of	IN
cord-000947-psguw47w	166	5	the	the	DT
cord-000947-psguw47w	166	6	scFv	scfv	JJ
cord-000947-psguw47w	166	7	ACZ28696.1	ACZ28696.1	NNP
cord-000947-psguw47w	166	8	was	be	VBD
cord-000947-psguw47w	166	9	known	know	VBN
cord-000947-psguw47w	166	10	,	,	,
cord-000947-psguw47w	166	11	the	the	DT
cord-000947-psguw47w	166	12	CDRs	cdr	NNS
cord-000947-psguw47w	166	13	of	of	IN
cord-000947-psguw47w	166	14	scFv	scFv	NNP
cord-000947-psguw47w	166	15	-	-	HYPH
cord-000947-psguw47w	166	16	A4	A4	NNP
cord-000947-psguw47w	166	17	was	be	VBD
cord-000947-psguw47w	166	18	inferred	infer	VBN
cord-000947-psguw47w	166	19	from	from	IN
cord-000947-psguw47w	166	20	the	the	DT
cord-000947-psguw47w	166	21	alignment	alignment	NN
cord-000947-psguw47w	166	22	result	result	NN
cord-000947-psguw47w	166	23	of	of	IN
cord-000947-psguw47w	166	24	the	the	DT
cord-000947-psguw47w	166	25	two	two	CD
cord-000947-psguw47w	166	26	sequences	sequence	NNS
cord-000947-psguw47w	166	27	(	(	-LRB-
cord-000947-psguw47w	166	28	Figure	figure	NN
cord-000947-psguw47w	166	29	1	1	CD
cord-000947-psguw47w	166	30	)	)	-RRB-
cord-000947-psguw47w	166	31	.	.	.
cord-000947-psguw47w	167	1	The	the	DT
cord-000947-psguw47w	167	2	resulted	resulted	JJ
cord-000947-psguw47w	167	3	CDR	cdr	NN
cord-000947-psguw47w	167	4	assignment	assignment	NN
cord-000947-psguw47w	167	5	was	be	VBD
cord-000947-psguw47w	167	6	checked	check	VBN
cord-000947-psguw47w	167	7	to	to	TO
cord-000947-psguw47w	167	8	be	be	VB
cord-000947-psguw47w	167	9	complied	comply	VBN
cord-000947-psguw47w	167	10	with	with	IN
cord-000947-psguw47w	167	11	the	the	DT
cord-000947-psguw47w	167	12	Kabat	Kabat	NNP
cord-000947-psguw47w	167	13	numbering	numbering	NN
cord-000947-psguw47w	167	14	rules	rule	NNS
cord-000947-psguw47w	167	15	[	[	-LRB-
cord-000947-psguw47w	167	16	45	45	CD
cord-000947-psguw47w	167	17	]	]	-RRB-
cord-000947-psguw47w	167	18	.	.	.
cord-000947-psguw47w	168	1	The	the	DT
cord-000947-psguw47w	168	2	crystal	crystal	JJ
cord-000947-psguw47w	168	3	structure	structure	NN
cord-000947-psguw47w	168	4	of	of	IN
cord-000947-psguw47w	168	5	HCK	HCK	NNP
cord-000947-psguw47w	168	6	was	be	VBD
cord-000947-psguw47w	168	7	available	available	JJ
cord-000947-psguw47w	168	8	in	in	IN
cord-000947-psguw47w	168	9	PDB	PDB	NNP
cord-000947-psguw47w	168	10	file	file	NN
cord-000947-psguw47w	168	11	1I0E	1i0e	CD
cord-000947-psguw47w	168	12	[	[	-LRB-
cord-000947-psguw47w	168	13	46	46	CD
cord-000947-psguw47w	168	14	]	]	-RRB-
cord-000947-psguw47w	168	15	.	.	.
cord-000947-psguw47w	169	1	HCK	HCK	NNP
cord-000947-psguw47w	169	2	is	be	VBZ
cord-000947-psguw47w	169	3	a	a	DT
cord-000947-psguw47w	169	4	dimmer	dimmer	NN
cord-000947-psguw47w	169	5	in	in	IN
cord-000947-psguw47w	169	6	nature	nature	NN
cord-000947-psguw47w	169	7	but	but	CC
cord-000947-psguw47w	169	8	the	the	DT
cord-000947-psguw47w	169	9	1I0E	1i0e	CD
cord-000947-psguw47w	169	10	only	only	RB
cord-000947-psguw47w	169	11	contains	contain	VBZ
cord-000947-psguw47w	169	12	a	a	DT
cord-000947-psguw47w	170	1	Each	each	DT
cord-000947-psguw47w	170	2	peptide	peptide	NN
cord-000947-psguw47w	170	3	epitope	epitope	NN
cord-000947-psguw47w	170	4	was	be	VBD
cord-000947-psguw47w	170	5	noted	note	VBN
cord-000947-psguw47w	170	6	by	by	IN
cord-000947-psguw47w	170	7	its	-PRON-	PRP$
cord-000947-psguw47w	170	8	sequence	sequence	NN
cord-000947-psguw47w	170	9	region	region	NN
cord-000947-psguw47w	170	10	on	on	IN
cord-000947-psguw47w	170	11	HCK	HCK	NNP
cord-000947-psguw47w	170	12	.	.	.
cord-000947-psguw47w	171	1	There	there	EX
cord-000947-psguw47w	171	2	were	be	VBD
cord-000947-psguw47w	171	3	total	total	JJ
cord-000947-psguw47w	171	4	eight	eight	CD
cord-000947-psguw47w	171	5	epitopes	epitope	NNS
cord-000947-psguw47w	171	6	predicted	predict	VBN
cord-000947-psguw47w	171	7	by	by	IN
cord-000947-psguw47w	171	8	both	both	DT
cord-000947-psguw47w	171	9	software	software	NN
cord-000947-psguw47w	171	10	and	and	CC
cord-000947-psguw47w	171	11	their	-PRON-	PRP$
cord-000947-psguw47w	171	12	overlapping	overlap	VBG
cord-000947-psguw47w	171	13	region	region	NN
cord-000947-psguw47w	171	14	was	be	VBD
cord-000947-psguw47w	171	15	listed	list	VBN
cord-000947-psguw47w	171	16	at	at	IN
cord-000947-psguw47w	171	17	the	the	DT
cord-000947-psguw47w	171	18	right	right	JJ
cord-000947-psguw47w	171	19	column	column	NN
cord-000947-psguw47w	171	20	.	.	.
cord-000947-psguw47w	172	1	doi:10.1371	doi:10.1371	NNP
cord-000947-psguw47w	172	2	/	/	SYM
cord-000947-psguw47w	172	3	journal.pone.0062147.t001	journal.pone.0062147.t001	NNP
cord-000947-psguw47w	172	4	Figure	Figure	NNP
cord-000947-psguw47w	172	5	4	4	CD
cord-000947-psguw47w	172	6	.	.	.
cord-000947-psguw47w	173	1	Positions	position	NNS
cord-000947-psguw47w	173	2	of	of	IN
cord-000947-psguw47w	173	3	the	the	DT
cord-000947-psguw47w	173	4	peptides	peptide	NNS
cord-000947-psguw47w	173	5	screened	screen	VBN
cord-000947-psguw47w	173	6	out	out	RP
cord-000947-psguw47w	173	7	by	by	IN
cord-000947-psguw47w	173	8	the	the	DT
cord-000947-psguw47w	173	9	peptide	peptide	NN
cord-000947-psguw47w	173	10	array	array	NN
cord-000947-psguw47w	173	11	membrane	membrane	NN
cord-000947-psguw47w	173	12	method	method	NN
cord-000947-psguw47w	173	13	on	on	IN
cord-000947-psguw47w	173	14	the	the	DT
cord-000947-psguw47w	173	15	HCK	HCK	NNP
cord-000947-psguw47w	173	16	3D	3D	NNP
cord-000947-psguw47w	173	17	structure	structure	NN
cord-000947-psguw47w	173	18	.	.	.
cord-000947-psguw47w	174	1	The	the	DT
cord-000947-psguw47w	174	2	six	six	CD
cord-000947-psguw47w	174	3	experimental	experimental	JJ
cord-000947-psguw47w	174	4	positive	positive	JJ
cord-000947-psguw47w	174	5	peptides	peptide	NNS
cord-000947-psguw47w	174	6	were	be	VBD
cord-000947-psguw47w	174	7	colored	color	VBN
cord-000947-psguw47w	174	8	in	in	IN
cord-000947-psguw47w	174	9	salmon	salmon	NN
cord-000947-psguw47w	174	10	and	and	CC
cord-000947-psguw47w	174	11	represented	represent	VBN
cord-000947-psguw47w	174	12	by	by	IN
cord-000947-psguw47w	174	13	using	use	VBG
cord-000947-psguw47w	174	14	the	the	DT
cord-000947-psguw47w	174	15	stick	stick	NNP
cord-000947-psguw47w	174	16	model	model	NN
cord-000947-psguw47w	174	17	.	.	.
cord-000947-psguw47w	175	1	As	as	IN
cord-000947-psguw47w	175	2	shown	show	VBN
cord-000947-psguw47w	175	3	in	in	IN
cord-000947-psguw47w	175	4	the	the	DT
cord-000947-psguw47w	175	5	picture	picture	NN
cord-000947-psguw47w	175	6	,	,	,
cord-000947-psguw47w	175	7	ASN5-TYR14	asn5-tyr14	RB
cord-000947-psguw47w	175	8	is	be	VBZ
cord-000947-psguw47w	175	9	at	at	IN
cord-000947-psguw47w	175	10	the	the	DT
cord-000947-psguw47w	175	11	position	position	NN
cord-000947-psguw47w	175	12	of	of	IN
cord-000947-psguw47w	175	13	dimerization	dimerization	NN
cord-000947-psguw47w	175	14	interface	interface	NN
cord-000947-psguw47w	175	15	of	of	IN
cord-000947-psguw47w	175	16	the	the	DT
cord-000947-psguw47w	175	17	two	two	CD
cord-000947-psguw47w	175	18	monomers	monomer	NNS
cord-000947-psguw47w	175	19	;	;	:
cord-000947-psguw47w	175	20	SER129-LYS138	SER129-LYS138	NNP
cord-000947-psguw47w	175	21	is	be	VBZ
cord-000947-psguw47w	175	22	completely	completely	RB
cord-000947-psguw47w	175	23	embedded	embed	VBN
cord-000947-psguw47w	175	24	inside	inside	IN
cord-000947-psguw47w	175	25	the	the	DT
cord-000947-psguw47w	175	26	structure	structure	NN
cord-000947-psguw47w	175	27	;	;	:
cord-000947-psguw47w	175	28	GLU248-LEU257	GLU248-LEU257	NNP
cord-000947-psguw47w	175	29	is	be	VBZ
cord-000947-psguw47w	175	30	in	in	IN
cord-000947-psguw47w	175	31	a	a	DT
cord-000947-psguw47w	175	32	dent	dent	NN
cord-000947-psguw47w	175	33	of	of	IN
cord-000947-psguw47w	175	34	the	the	DT
cord-000947-psguw47w	175	35	surface	surface	NN
cord-000947-psguw47w	175	36	;	;	:
cord-000947-psguw47w	175	37	LYS265-ASN274	LYS265-ASN274	NNP
cord-000947-psguw47w	175	38	which	which	WDT
cord-000947-psguw47w	175	39	contains	contain	VBZ
cord-000947-psguw47w	175	40	V8	V8	NNP
cord-000947-psguw47w	175	41	endoproteinase	endoproteinase	NN
cord-000947-psguw47w	175	42	fragment	fragment	NN
cord-000947-psguw47w	175	43	was	be	VBD
cord-000947-psguw47w	175	44	also	also	RB
cord-000947-psguw47w	175	45	in	in	IN
cord-000947-psguw47w	175	46	a	a	DT
cord-000947-psguw47w	175	47	dent	dent	NN
cord-000947-psguw47w	175	48	of	of	IN
cord-000947-psguw47w	175	49	the	the	DT
cord-000947-psguw47w	175	50	structure	structure	NN
cord-000947-psguw47w	175	51	;	;	:
cord-000947-psguw47w	175	52	LYS170-MET179	LYS170-MET179	NNP
cord-000947-psguw47w	175	53	is	be	VBZ
cord-000947-psguw47w	175	54	located	locate	VBN
cord-000947-psguw47w	175	55	at	at	IN
cord-000947-psguw47w	175	56	the	the	DT
cord-000947-psguw47w	175	57	bottom	bottom	NN
cord-000947-psguw47w	175	58	of	of	IN
cord-000947-psguw47w	175	59	the	the	DT
cord-000947-psguw47w	175	60	structure	structure	NN
cord-000947-psguw47w	175	61	;	;	:
cord-000947-psguw47w	175	62	THR313-THR322	THR313-THR322	NNP
cord-000947-psguw47w	175	63	is	be	VBZ
cord-000947-psguw47w	175	64	located	locate	VBN
cord-000947-psguw47w	175	65	in	in	IN
cord-000947-psguw47w	175	66	the	the	DT
cord-000947-psguw47w	175	67	largest	large	JJS
cord-000947-psguw47w	175	68	groove	groove	NN
cord-000947-psguw47w	175	69	of	of	IN
cord-000947-psguw47w	175	70	the	the	DT
cord-000947-psguw47w	175	71	structure	structure	NN
cord-000947-psguw47w	175	72	.	.	.
cord-000947-psguw47w	176	1	doi:10.1371	doi:10.1371	NNP
cord-000947-psguw47w	177	1	/journal.pone.0062147.g004	/journal.pone.0062147.g004	.
cord-000947-psguw47w	177	2	monomer	monomer	NN
cord-000947-psguw47w	177	3	and	and	CC
cord-000947-psguw47w	177	4	the	the	DT
cord-000947-psguw47w	177	5	structure	structure	NN
cord-000947-psguw47w	177	6	of	of	IN
cord-000947-psguw47w	177	7	two	two	CD
cord-000947-psguw47w	177	8	peptide	peptide	NN
cord-000947-psguw47w	177	9	fragments	fragment	NNS
cord-000947-psguw47w	177	10	,	,	,
cord-000947-psguw47w	177	11	MET1-HIS7	MET1-HIS7	NNP
cord-000947-psguw47w	177	12	and	and	CC
cord-000947-psguw47w	177	13	GLY323-GLY331	gly323-gly331	NN
cord-000947-psguw47w	177	14	,	,	,
cord-000947-psguw47w	177	15	was	be	VBD
cord-000947-psguw47w	177	16	missing	miss	VBG
cord-000947-psguw47w	177	17	.	.	.
cord-000947-psguw47w	178	1	Thus	thus	RB
cord-000947-psguw47w	178	2	we	-PRON-	PRP
cord-000947-psguw47w	178	3	use	use	VBP
cord-000947-psguw47w	178	4	another	another	DT
cord-000947-psguw47w	178	5	CK	CK	NNP
cord-000947-psguw47w	178	6	structure	structure	NN
cord-000947-psguw47w	178	7	,	,	,
cord-000947-psguw47w	178	8	the	the	DT
cord-000947-psguw47w	178	9	1U6R	1u6r	CD
cord-000947-psguw47w	178	10	for	for	IN
cord-000947-psguw47w	178	11	rabbit	rabbit	NN
cord-000947-psguw47w	178	12	CK	CK	NNP
cord-000947-psguw47w	178	13	in	in	IN
cord-000947-psguw47w	178	14	PDB	PDB	NNP
cord-000947-psguw47w	178	15	as	as	IN
cord-000947-psguw47w	178	16	the	the	DT
cord-000947-psguw47w	178	17	homology	homology	NN
cord-000947-psguw47w	178	18	modeling	modeling	NN
cord-000947-psguw47w	178	19	template	template	NN
cord-000947-psguw47w	178	20	.	.	.
cord-000947-psguw47w	179	1	The	the	DT
cord-000947-psguw47w	179	2	sequence	sequence	NN
cord-000947-psguw47w	179	3	identity	identity	NN
cord-000947-psguw47w	179	4	between	between	IN
cord-000947-psguw47w	179	5	rabbit	rabbit	NN
cord-000947-psguw47w	179	6	CK	CK	NNP
cord-000947-psguw47w	179	7	and	and	CC
cord-000947-psguw47w	179	8	HCK	HCK	NNP
cord-000947-psguw47w	179	9	is	be	VBZ
cord-000947-psguw47w	179	10	96	96	CD
cord-000947-psguw47w	179	11	%	%	NN
cord-000947-psguw47w	179	12	and	and	CC
cord-000947-psguw47w	179	13	the	the	DT
cord-000947-psguw47w	179	14	1U6R	1u6r	CD
cord-000947-psguw47w	179	15	file	file	NN
cord-000947-psguw47w	179	16	contains	contain	VBZ
cord-000947-psguw47w	179	17	the	the	DT
cord-000947-psguw47w	179	18	structure	structure	NN
cord-000947-psguw47w	179	19	of	of	IN
cord-000947-psguw47w	179	20	the	the	DT
cord-000947-psguw47w	179	21	two	two	CD
cord-000947-psguw47w	179	22	missing	miss	VBG
cord-000947-psguw47w	179	23	fragments	fragment	NNS
cord-000947-psguw47w	179	24	peptides	peptide	NNS
cord-000947-psguw47w	179	25	of	of	IN
cord-000947-psguw47w	179	26	the	the	DT
cord-000947-psguw47w	179	27	1I0E	1i0e	CD
cord-000947-psguw47w	179	28	file	file	NN
cord-000947-psguw47w	179	29	.	.	.
cord-000947-psguw47w	180	1	We	-PRON-	PRP
cord-000947-psguw47w	180	2	used	use	VBD
cord-000947-psguw47w	180	3	FBCPred	FBCPred	NNP
cord-000947-psguw47w	180	4	[	[	-LRB-
cord-000947-psguw47w	180	5	26	26	CD
cord-000947-psguw47w	180	6	]	]	-RRB-
cord-000947-psguw47w	180	7	based	base	VBN
cord-000947-psguw47w	180	8	on	on	IN
cord-000947-psguw47w	180	9	the	the	DT
cord-000947-psguw47w	180	10	machine	machine	NN
cord-000947-psguw47w	180	11	learning	learning	NN
cord-000947-psguw47w	180	12	method	method	NN
cord-000947-psguw47w	180	13	and	and	CC
cord-000947-psguw47w	180	14	ElliPro	ElliPro	NNP
cord-000947-psguw47w	180	15	[	[	-LRB-
cord-000947-psguw47w	180	16	30	30	CD
cord-000947-psguw47w	180	17	]	]	-RRB-
cord-000947-psguw47w	180	18	based	base	VBN
cord-000947-psguw47w	180	19	on	on	IN
cord-000947-psguw47w	180	20	the	the	DT
cord-000947-psguw47w	180	21	3D	3d	JJ
cord-000947-psguw47w	180	22	structure	structure	NN
cord-000947-psguw47w	180	23	for	for	IN
cord-000947-psguw47w	180	24	epitope	epitope	NN
cord-000947-psguw47w	180	25	prediction	prediction	NN
cord-000947-psguw47w	180	26	.	.	.
cord-000947-psguw47w	181	1	An	an	DT
cord-000947-psguw47w	181	2	epitope	epitope	NN
cord-000947-psguw47w	181	3	predicted	predict	VBN
cord-000947-psguw47w	181	4	by	by	IN
cord-000947-psguw47w	181	5	both	both	DT
cord-000947-psguw47w	181	6	methods	method	NNS
cord-000947-psguw47w	181	7	would	would	MD
cord-000947-psguw47w	181	8	be	be	VB
cord-000947-psguw47w	181	9	regarded	regard	VBN
cord-000947-psguw47w	181	10	as	as	IN
cord-000947-psguw47w	181	11	a	a	DT
cord-000947-psguw47w	181	12	potential	potential	JJ
cord-000947-psguw47w	181	13	epitope	epitope	NN
cord-000947-psguw47w	181	14	.	.	.
cord-000947-psguw47w	182	1	As	as	IN
cord-000947-psguw47w	182	2	for	for	IN
cord-000947-psguw47w	182	3	FBCPred	fbcpred	JJ
cord-000947-psguw47w	182	4	,	,	,
cord-000947-psguw47w	182	5	default	default	NN
cord-000947-psguw47w	182	6	parameters	parameter	NNS
cord-000947-psguw47w	182	7	were	be	VBD
cord-000947-psguw47w	182	8	adopted	adopt	VBN
cord-000947-psguw47w	182	9	for	for	IN
cord-000947-psguw47w	182	10	linear	linear	JJ
cord-000947-psguw47w	182	11	epitope	epitope	NNP
cord-000947-psguw47w	182	12	prediction	prediction	NN
cord-000947-psguw47w	182	13	,	,	,
cord-000947-psguw47w	182	14	the	the	DT
cord-000947-psguw47w	182	15	length	length	NN
cord-000947-psguw47w	182	16	of	of	IN
cord-000947-psguw47w	182	17	the	the	DT
cord-000947-psguw47w	182	18	linear	linear	JJ
cord-000947-psguw47w	182	19	epitopes	epitope	NNS
cord-000947-psguw47w	182	20	was	be	VBD
cord-000947-psguw47w	182	21	set	set	VBN
cord-000947-psguw47w	182	22	to	to	IN
cord-000947-psguw47w	182	23	14	14	CD
cord-000947-psguw47w	182	24	,	,	,
cord-000947-psguw47w	182	25	and	and	CC
cord-000947-psguw47w	182	26	the	the	DT
cord-000947-psguw47w	182	27	specificity	specificity	NN
cord-000947-psguw47w	182	28	was	be	VBD
cord-000947-psguw47w	182	29	75	75	CD
cord-000947-psguw47w	182	30	%	%	NN
cord-000947-psguw47w	182	31	as	as	IN
cord-000947-psguw47w	182	32	default	default	NN
cord-000947-psguw47w	182	33	.	.	.
cord-000947-psguw47w	183	1	No	no	DT
cord-000947-psguw47w	183	2	parameter	parameter	NN
cord-000947-psguw47w	183	3	was	be	VBD
cord-000947-psguw47w	183	4	needed	need	VBN
cord-000947-psguw47w	183	5	for	for	IN
cord-000947-psguw47w	183	6	ElliPro	ElliPro	NNP
cord-000947-psguw47w	183	7	.	.	.
cord-000947-psguw47w	184	1	12	12	CD
cord-000947-psguw47w	184	2	mer	mer	NNP
cord-000947-psguw47w	184	3	peptides	peptide	NNS
cord-000947-psguw47w	184	4	from	from	IN
cord-000947-psguw47w	184	5	the	the	DT
cord-000947-psguw47w	184	6	HCK	HCK	NNP
cord-000947-psguw47w	184	7	sequence	sequence	NN
cord-000947-psguw47w	184	8	were	be	VBD
cord-000947-psguw47w	184	9	synthesized	synthesize	VBN
cord-000947-psguw47w	184	10	on	on	IN
cord-000947-psguw47w	184	11	nitrocellulose	nitrocellulose	VBG
cord-000947-psguw47w	184	12	membrane	membrane	NN
cord-000947-psguw47w	184	13	as	as	IN
cord-000947-psguw47w	184	14	individual	individual	JJ
cord-000947-psguw47w	184	15	spots	spot	NNS
cord-000947-psguw47w	184	16	.	.	.
cord-000947-psguw47w	185	1	Peptide	peptide	NN
cord-000947-psguw47w	185	2	sequences	sequence	NNS
cord-000947-psguw47w	185	3	were	be	VBD
cord-000947-psguw47w	185	4	started	start	VBN
cord-000947-psguw47w	185	5	from	from	IN
cord-000947-psguw47w	185	6	HCK	HCK	NNP
cord-000947-psguw47w	185	7	N	N	NNP
cord-000947-psguw47w	185	8	-	-	HYPH
cord-000947-psguw47w	185	9	terminal	terminal	NN
cord-000947-psguw47w	185	10	and	and	CC
cord-000947-psguw47w	185	11	each	each	DT
cord-000947-psguw47w	185	12	subsequent	subsequent	JJ
cord-000947-psguw47w	185	13	peptides	peptide	NNS
cord-000947-psguw47w	185	14	shift	shift	VBP
cord-000947-psguw47w	185	15	one	one	CD
cord-000947-psguw47w	185	16	position	position	NN
cord-000947-psguw47w	185	17	to	to	IN
cord-000947-psguw47w	185	18	the	the	DT
cord-000947-psguw47w	185	19	right	right	NN
cord-000947-psguw47w	185	20	.	.	.
cord-000947-psguw47w	186	1	A	a	DT
cord-000947-psguw47w	186	2	set	set	NN
cord-000947-psguw47w	186	3	of	of	IN
cord-000947-psguw47w	186	4	such	such	JJ
cord-000947-psguw47w	186	5	peptides	peptide	NNS
cord-000947-psguw47w	186	6	completely	completely	RB
cord-000947-psguw47w	186	7	sampled	sample	VBD
cord-000947-psguw47w	186	8	the	the	DT
cord-000947-psguw47w	186	9	whole	whole	JJ
cord-000947-psguw47w	186	10	HCK	HCK	NNP
cord-000947-psguw47w	186	11	sequence	sequence	NN
cord-000947-psguw47w	186	12	and	and	CC
cord-000947-psguw47w	186	13	formed	form	VBD
cord-000947-psguw47w	186	14	an	an	DT
cord-000947-psguw47w	186	15	array	array	NN
cord-000947-psguw47w	186	16	on	on	IN
cord-000947-psguw47w	186	17	the	the	DT
cord-000947-psguw47w	186	18	membrane	membrane	NN
cord-000947-psguw47w	186	19	.	.	.
cord-000947-psguw47w	187	1	The	the	DT
cord-000947-psguw47w	187	2	peptide	peptide	JJ
cord-000947-psguw47w	187	3	array	array	NN
cord-000947-psguw47w	187	4	membrane	membrane	NN
cord-000947-psguw47w	187	5	was	be	VBD
cord-000947-psguw47w	187	6	incubated	incubate	VBN
cord-000947-psguw47w	187	7	with	with	IN
cord-000947-psguw47w	187	8	purified	purify	VBN
cord-000947-psguw47w	187	9	scFv	scFv	NNP
cord-000947-psguw47w	187	10	-	-	HYPH
cord-000947-psguw47w	187	11	A4	a4	NN
cord-000947-psguw47w	187	12	antibodies	antibody	NNS
cord-000947-psguw47w	187	13	in	in	IN
cord-000947-psguw47w	187	14	the	the	DT
cord-000947-psguw47w	187	15	MP	MP	NNP
cord-000947-psguw47w	187	16	buffer	buffer	NN
cord-000947-psguw47w	187	17	(	(	-LRB-
cord-000947-psguw47w	187	18	30	30	CD
cord-000947-psguw47w	187	19	mM	mM	NNP
cord-000947-psguw47w	187	20	Tris	Tris	NNP
cord-000947-psguw47w	187	21	-	-	HYPH
cord-000947-psguw47w	187	22	HCl	HCl	NNP
cord-000947-psguw47w	187	23	,	,	,
cord-000947-psguw47w	187	24	pH	pH	NNP
cord-000947-psguw47w	187	25	7.6	7.6	CD
cord-000947-psguw47w	187	26	,	,	,
cord-000947-psguw47w	187	27	170	170	CD
cord-000947-psguw47w	187	28	mM	mm	CD
cord-000947-psguw47w	187	29	NaCl	nacl	NN
cord-000947-psguw47w	187	30	,	,	,
cord-000947-psguw47w	187	31	6.4	6.4	CD
cord-000947-psguw47w	187	32	mM	mm	CD
cord-000947-psguw47w	187	33	KCl	KCl	NNS
cord-000947-psguw47w	187	34	,	,	,
cord-000947-psguw47w	187	35	0.05	0.05	CD
cord-000947-psguw47w	187	36	%	%	NN
cord-000947-psguw47w	187	37	Tween	Tween	NNP
cord-000947-psguw47w	187	38	20	20	CD
cord-000947-psguw47w	187	39	,	,	,
cord-000947-psguw47w	187	40	5	5	CD
cord-000947-psguw47w	187	41	%	%	NN
cord-000947-psguw47w	187	42	sucrose	sucrose	NN
cord-000947-psguw47w	187	43	)	)	-RRB-
cord-000947-psguw47w	187	44	overnight	overnight	RB
cord-000947-psguw47w	187	45	at	at	IN
cord-000947-psguw47w	187	46	4uC	4uc	CD
cord-000947-psguw47w	187	47	with	with	IN
cord-000947-psguw47w	187	48	gentle	gentle	JJ
cord-000947-psguw47w	187	49	shaking	shaking	NN
cord-000947-psguw47w	187	50	.	.	.
cord-000947-psguw47w	188	1	Unbound	unbound	JJ
cord-000947-psguw47w	188	2	antibodies	antibody	NNS
cord-000947-psguw47w	188	3	were	be	VBD
cord-000947-psguw47w	188	4	removed	remove	VBN
cord-000947-psguw47w	188	5	with	with	IN
cord-000947-psguw47w	188	6	TBS	TBS	NNP
cord-000947-psguw47w	188	7	(	(	-LRB-
cord-000947-psguw47w	188	8	4uC	4uc	CD
cord-000947-psguw47w	188	9	)	)	-RRB-
cord-000947-psguw47w	189	1	andthe	andthe	NNP
cord-000947-psguw47w	189	2	antibodies	antibody	NNS
cord-000947-psguw47w	189	3	bound	bind	VBN
cord-000947-psguw47w	189	4	were	be	VBD
cord-000947-psguw47w	189	5	electro	electro	JJ
cord-000947-psguw47w	189	6	-	-	HYPH
cord-000947-psguw47w	189	7	transferred	transfer	VBN
cord-000947-psguw47w	189	8	onto	onto	IN
cord-000947-psguw47w	189	9	a	a	DT
cord-000947-psguw47w	189	10	PVDF	PVDF	NNP
cord-000947-psguw47w	189	11	membrane	membrane	NN
cord-000947-psguw47w	189	12	using	use	VBG
cord-000947-psguw47w	189	13	a	a	DT
cord-000947-psguw47w	189	14	semi	semi	JJ
cord-000947-psguw47w	189	15	-	-	JJ
cord-000947-psguw47w	189	16	dry	dry	JJ
cord-000947-psguw47w	189	17	blotter	blotter	NN
cord-000947-psguw47w	189	18	(	(	-LRB-
cord-000947-psguw47w	189	19	0.8	0.8	CD
cord-000947-psguw47w	189	20	mA	mA	NNP
cord-000947-psguw47w	189	21	/	/	SYM
cord-000947-psguw47w	189	22	cm2	cm2	NNP
cord-000947-psguw47w	189	23	,	,	,
cord-000947-psguw47w	189	24	three	three	CD
cord-000947-psguw47w	189	25	hours	hour	NNS
cord-000947-psguw47w	189	26	)	)	-RRB-
cord-000947-psguw47w	189	27	.	.	.
cord-000947-psguw47w	190	1	The	the	DT
cord-000947-psguw47w	190	2	membrane	membrane	NN
cord-000947-psguw47w	190	3	was	be	VBD
cord-000947-psguw47w	190	4	blocked	block	VBN
cord-000947-psguw47w	190	5	with	with	IN
cord-000947-psguw47w	190	6	5	5	CD
cord-000947-psguw47w	190	7	%	%	NN
cord-000947-psguw47w	190	8	non	non	JJ
cord-000947-psguw47w	190	9	-	-	JJ
cord-000947-psguw47w	190	10	fat	fat	JJ
cord-000947-psguw47w	190	11	dry	dry	JJ
cord-000947-psguw47w	190	12	milk	milk	NN
cord-000947-psguw47w	190	13	for	for	IN
cord-000947-psguw47w	190	14	2	2	CD
cord-000947-psguw47w	190	15	h	h	NN
cord-000947-psguw47w	190	16	and	and	CC
cord-000947-psguw47w	190	17	incubated	incubate	VBN
cord-000947-psguw47w	190	18	with	with	IN
cord-000947-psguw47w	190	19	the	the	DT
cord-000947-psguw47w	190	20	primary	primary	JJ
cord-000947-psguw47w	190	21	antibody	antibody	NN
cord-000947-psguw47w	190	22	(	(	-LRB-
cord-000947-psguw47w	190	23	anti	anti	JJ
cord-000947-psguw47w	190	24	-	-	JJ
cord-000947-psguw47w	190	25	V5	v5	JJ
cord-000947-psguw47w	190	26	antibody	antibody	NN
cord-000947-psguw47w	190	27	)	)	-RRB-
cord-000947-psguw47w	190	28	overnight	overnight	RB
cord-000947-psguw47w	190	29	at	at	IN
cord-000947-psguw47w	190	30	4uC.	4uc.	CD
cord-000947-psguw47w	190	31	After	after	IN
cord-000947-psguw47w	190	32	being	be	VBG
cord-000947-psguw47w	190	33	washed	wash	VBN
cord-000947-psguw47w	190	34	with	with	IN
cord-000947-psguw47w	190	35	TBS	TBS	NNP
cord-000947-psguw47w	190	36	buffer	buffer	NN
cord-000947-psguw47w	190	37	for	for	IN
cord-000947-psguw47w	190	38	three	three	CD
cord-000947-psguw47w	190	39	times	time	NNS
cord-000947-psguw47w	190	40	,	,	,
cord-000947-psguw47w	190	41	the	the	DT
cord-000947-psguw47w	190	42	membrane	membrane	NN
cord-000947-psguw47w	190	43	was	be	VBD
cord-000947-psguw47w	190	44	incubated	incubate	VBN
cord-000947-psguw47w	190	45	with	with	IN
cord-000947-psguw47w	190	46	the	the	DT
cord-000947-psguw47w	190	47	alkaline	alkaline	JJ
cord-000947-psguw47w	190	48	phosphatase	phosphatase	NN
cord-000947-psguw47w	190	49	-	-	HYPH
cord-000947-psguw47w	190	50	conjugated	conjugate	VBN
cord-000947-psguw47w	190	51	secondary	secondary	JJ
cord-000947-psguw47w	190	52	antibodies	antibody	NNS
cord-000947-psguw47w	190	53	for	for	IN
cord-000947-psguw47w	190	54	1	1	CD
cord-000947-psguw47w	190	55	hour	hour	NN
cord-000947-psguw47w	190	56	and	and	CC
cord-000947-psguw47w	190	57	developed	develop	VBD
cord-000947-psguw47w	190	58	using	use	VBG
cord-000947-psguw47w	190	59	the	the	DT
cord-000947-psguw47w	190	60	enhanced	enhance	VBN
cord-000947-psguw47w	190	61	chemiluminescence	chemiluminescence	NN
cord-000947-psguw47w	190	62	method	method	NN
cord-000947-psguw47w	190	63	.	.	.
cord-000947-psguw47w	191	1	The	the	DT
cord-000947-psguw47w	191	2	ZODCK	ZODCK	NNP
cord-000947-psguw47w	191	3	Server	server	NN
cord-000947-psguw47w	191	4	was	be	VBD
cord-000947-psguw47w	191	5	used	use	VBN
cord-000947-psguw47w	191	6	to	to	TO
cord-000947-psguw47w	191	7	dock	dock	VB
cord-000947-psguw47w	191	8	scFv	scFv	NNP
cord-000947-psguw47w	191	9	-	-	HYPH
cord-000947-psguw47w	191	10	A4	a4	NN
cord-000947-psguw47w	191	11	to	to	IN
cord-000947-psguw47w	191	12	HCK	HCK	NNP
cord-000947-psguw47w	191	13	.	.	.
cord-000947-psguw47w	192	1	The	the	DT
cord-000947-psguw47w	192	2	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	192	3	Server	Server	NNP
cord-000947-psguw47w	192	4	allowed	allow	VBD
cord-000947-psguw47w	192	5	user	user	NN
cord-000947-psguw47w	192	6	to	to	TO
cord-000947-psguw47w	192	7	pick	pick	VB
cord-000947-psguw47w	192	8	contact	contact	NN
cord-000947-psguw47w	192	9	and	and	CC
cord-000947-psguw47w	192	10	blocking	block	VBG
cord-000947-psguw47w	192	11	residues	residue	NNS
cord-000947-psguw47w	192	12	of	of	IN
cord-000947-psguw47w	192	13	the	the	DT
cord-000947-psguw47w	192	14	proteins	protein	NNS
cord-000947-psguw47w	192	15	for	for	IN
cord-000947-psguw47w	192	16	docking	docking	NN
cord-000947-psguw47w	192	17	.	.	.
cord-000947-psguw47w	193	1	The	the	DT
cord-000947-psguw47w	193	2	HCK	HCK	NNP
cord-000947-psguw47w	193	3	residues	residue	NNS
cord-000947-psguw47w	193	4	of	of	IN
cord-000947-psguw47w	193	5	the	the	DT
cord-000947-psguw47w	193	6	predicted	predict	VBN
cord-000947-psguw47w	193	7	epitopes	epitope	NNS
cord-000947-psguw47w	193	8	were	be	VBD
cord-000947-psguw47w	193	9	chosen	choose	VBN
cord-000947-psguw47w	193	10	as	as	IN
cord-000947-psguw47w	193	11	contact	contact	NN
cord-000947-psguw47w	193	12	residues	residue	NNS
cord-000947-psguw47w	193	13	for	for	IN
cord-000947-psguw47w	193	14	docking	docking	NN
cord-000947-psguw47w	193	15	.	.	.
cord-000947-psguw47w	194	1	There	there	EX
cord-000947-psguw47w	194	2	were	be	VBD
cord-000947-psguw47w	194	3	six	six	CD
cord-000947-psguw47w	194	4	linear	linear	JJ
cord-000947-psguw47w	194	5	peptides	peptide	NNS
cord-000947-psguw47w	194	6	exhibiting	exhibit	VBG
cord-000947-psguw47w	194	7	positive	positive	JJ
cord-000947-psguw47w	194	8	reactivity	reactivity	NN
cord-000947-psguw47w	194	9	with	with	IN
cord-000947-psguw47w	194	10	scFv	scFv	NNP
cord-000947-psguw47w	194	11	-	-	HYPH
cord-000947-psguw47w	194	12	A4	a4	NN
cord-000947-psguw47w	194	13	in	in	IN
cord-000947-psguw47w	194	14	the	the	DT
cord-000947-psguw47w	194	15	peptide	peptide	NN
cord-000947-psguw47w	194	16	array	array	NN
cord-000947-psguw47w	194	17	membrane	membrane	NN
cord-000947-psguw47w	194	18	experiment	experiment	NN
cord-000947-psguw47w	194	19	and	and	CC
cord-000947-psguw47w	194	20	the	the	DT
cord-000947-psguw47w	194	21	corresponding	correspond	VBG
cord-000947-psguw47w	194	22	portions	portion	NNS
cord-000947-psguw47w	194	23	of	of	IN
cord-000947-psguw47w	194	24	HCK	HCK	NNP
cord-000947-psguw47w	194	25	were	be	VBD
cord-000947-psguw47w	194	26	designated	designate	VBN
cord-000947-psguw47w	194	27	as	as	IN
cord-000947-psguw47w	194	28	the	the	DT
cord-000947-psguw47w	194	29	orientational	orientational	JJ
cord-000947-psguw47w	194	30	docking	docking	NN
cord-000947-psguw47w	194	31	sites	site	NNS
cord-000947-psguw47w	194	32	of	of	IN
cord-000947-psguw47w	194	33	HCK	HCK	NNP
cord-000947-psguw47w	194	34	.	.	.
cord-000947-psguw47w	195	1	No	no	DT
cord-000947-psguw47w	195	2	blocking	block	VBG
cord-000947-psguw47w	195	3	residues	residue	NNS
cord-000947-psguw47w	195	4	of	of	IN
cord-000947-psguw47w	195	5	HCK	HCK	NNP
cord-000947-psguw47w	195	6	were	be	VBD
cord-000947-psguw47w	195	7	selected	select	VBN
cord-000947-psguw47w	195	8	during	during	IN
cord-000947-psguw47w	195	9	docking	docking	NN
cord-000947-psguw47w	195	10	,	,	,
cord-000947-psguw47w	195	11	but	but	CC
cord-000947-psguw47w	195	12	for	for	IN
cord-000947-psguw47w	195	13	scFv	scFv	NNP
cord-000947-psguw47w	195	14	-	-	HYPH
cord-000947-psguw47w	195	15	A4	a4	NN
cord-000947-psguw47w	195	16	,	,	,
cord-000947-psguw47w	195	17	residues	residue	NNS
cord-000947-psguw47w	195	18	of	of	IN
cord-000947-psguw47w	195	19	the	the	DT
cord-000947-psguw47w	195	20	linker	linker	NN
cord-000947-psguw47w	195	21	segment	segment	NN
cord-000947-psguw47w	195	22	were	be	VBD
cord-000947-psguw47w	195	23	selected	select	VBN
cord-000947-psguw47w	195	24	as	as	IN
cord-000947-psguw47w	195	25	the	the	DT
cord-000947-psguw47w	195	26	blocking	block	VBG
cord-000947-psguw47w	195	27	residues	residue	NNS
cord-000947-psguw47w	195	28	.	.	.
cord-000947-psguw47w	196	1	RosettaDock	RosettaDock	NNP
cord-000947-psguw47w	196	2	was	be	VBD
cord-000947-psguw47w	196	3	used	use	VBN
cord-000947-psguw47w	196	4	to	to	TO
cord-000947-psguw47w	196	5	optimize	optimize	VB
cord-000947-psguw47w	196	6	the	the	DT
cord-000947-psguw47w	196	7	models	model	NNS
cord-000947-psguw47w	196	8	build	build	VB
cord-000947-psguw47w	196	9	by	by	IN
cord-000947-psguw47w	196	10	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	196	11	because	because	IN
cord-000947-psguw47w	196	12	it	-PRON-	PRP
cord-000947-psguw47w	196	13	implemented	implement	VBD
cord-000947-psguw47w	196	14	the	the	DT
cord-000947-psguw47w	196	15	flexible	flexible	JJ
cord-000947-psguw47w	196	16	docking	docking	NN
cord-000947-psguw47w	196	17	method	method	NN
cord-000947-psguw47w	196	18	and	and	CC
cord-000947-psguw47w	196	19	had	have	VBD
cord-000947-psguw47w	196	20	a	a	DT
cord-000947-psguw47w	196	21	scoring	scoring	NN
cord-000947-psguw47w	196	22	function	function	NN
cord-000947-psguw47w	196	23	of	of	IN
cord-000947-psguw47w	196	24	better	well	JJR
cord-000947-psguw47w	196	25	performance	performance	NN
cord-000947-psguw47w	196	26	.	.	.
cord-000947-psguw47w	197	1	The	the	DT
cord-000947-psguw47w	197	2	perturbation	perturbation	NN
cord-000947-psguw47w	197	3	docking	docking	NN
cord-000947-psguw47w	197	4	method	method	NN
cord-000947-psguw47w	197	5	of	of	IN
cord-000947-psguw47w	197	6	the	the	DT
cord-000947-psguw47w	197	7	Rosetta	Rosetta	NNP
cord-000947-psguw47w	197	8	-	-	HYPH
cord-000947-psguw47w	197	9	Dock	Dock	NNP
cord-000947-psguw47w	197	10	program	program	NN
cord-000947-psguw47w	197	11	was	be	VBD
cord-000947-psguw47w	197	12	applied	apply	VBN
cord-000947-psguw47w	197	13	and	and	CC
cord-000947-psguw47w	197	14	the	the	DT
cord-000947-psguw47w	197	15	three	three	CD
cord-000947-psguw47w	197	16	default	default	NN
cord-000947-psguw47w	197	17	perturbation	perturbation	NN
cord-000947-psguw47w	197	18	parameters	parameter	NNS
cord-000947-psguw47w	197	19	were	be	VBD
cord-000947-psguw47w	197	20	used	use	VBN
cord-000947-psguw47w	197	21	.	.	.
cord-000947-psguw47w	198	1	One	one	CD
cord-000947-psguw47w	198	2	thousand	thousand	CD
cord-000947-psguw47w	198	3	models	model	NNS
cord-000947-psguw47w	198	4	were	be	VBD
cord-000947-psguw47w	198	5	produced	produce	VBN
cord-000947-psguw47w	198	6	for	for	IN
cord-000947-psguw47w	198	7	each	each	DT
cord-000947-psguw47w	198	8	selected	select	VBN
cord-000947-psguw47w	198	9	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	198	10	model	model	NN
cord-000947-psguw47w	198	11	complex	complex	NN
cord-000947-psguw47w	198	12	.	.	.
cord-000947-psguw47w	199	1	Conceived	conceive	VBN
cord-000947-psguw47w	199	2	and	and	CC
cord-000947-psguw47w	199	3	designed	design	VBD
cord-000947-psguw47w	199	4	the	the	DT
cord-000947-psguw47w	199	5	experiments	experiment	NNS
cord-000947-psguw47w	199	6	:	:	:
cord-000947-psguw47w	199	7	JYF	JYF	NNP
cord-000947-psguw47w	199	8	TL	TL	NNP
cord-000947-psguw47w	199	9	.	.	.
cord-000947-psguw47w	200	1	Performed	perform	VBN
cord-000947-psguw47w	200	2	the	the	DT
cord-000947-psguw47w	200	3	experiments	experiment	NNS
cord-000947-psguw47w	200	4	:	:	:
cord-000947-psguw47w	200	5	HG	HG	NNP
cord-000947-psguw47w	200	6	SL	SL	NNP
cord-000947-psguw47w	200	7	.	.	.
cord-000947-psguw47w	201	1	Analyzed	analyze	VBD
cord-000947-psguw47w	201	2	the	the	DT
cord-000947-psguw47w	201	3	data	datum	NNS
cord-000947-psguw47w	201	4	:	:	:
cord-000947-psguw47w	201	5	JYF	JYF	NNP
cord-000947-psguw47w	201	6	TL	TL	NNP
cord-000947-psguw47w	201	7	.	.	.
cord-000947-psguw47w	202	1	Contributed	contribute	VBN
cord-000947-psguw47w	202	2	reagents/	reagents/	CD
cord-000947-psguw47w	202	3	materials	material	NNS
cord-000947-psguw47w	202	4	/	/	SYM
cord-000947-psguw47w	202	5	analysis	analysis	NN
cord-000947-psguw47w	202	6	tools	tool	NNS
cord-000947-psguw47w	202	7	:	:	:
cord-000947-psguw47w	202	8	SL	SL	NNP
cord-000947-psguw47w	202	9	.	.	.
cord-000947-psguw47w	203	1	Wrote	write	VBD
cord-000947-psguw47w	203	2	the	the	DT
cord-000947-psguw47w	203	3	paper	paper	NN
cord-000947-psguw47w	203	4	:	:	:
cord-000947-psguw47w	204	1	JYF	JYF	NNP
cord-000947-psguw47w	204	2	TL	TL	NNP
cord-000947-psguw47w	204	3	.	.	.
cord-000947-psguw47w	205	1	Figure	figure	NN
cord-000947-psguw47w	205	2	5	5	CD
cord-000947-psguw47w	205	3	.	.	.
cord-000947-psguw47w	206	1	The	the	DT
cord-000947-psguw47w	206	2	scFv	scFv	NNP
cord-000947-psguw47w	206	3	-	-	HYPH
cord-000947-psguw47w	206	4	A4-HCK	A4-HCK	NNP
cord-000947-psguw47w	206	5	complexes	complex	NNS
cord-000947-psguw47w	206	6	.	.	.
cord-000947-psguw47w	207	1	Model	model	NN
cord-000947-psguw47w	208	1	I	-PRON-	PRP
cord-000947-psguw47w	208	2	is	be	VBZ
cord-000947-psguw47w	208	3	shown	show	VBN
cord-000947-psguw47w	208	4	at	at	IN
cord-000947-psguw47w	208	5	left	left	NN
cord-000947-psguw47w	208	6	.	.	.
cord-000947-psguw47w	209	1	Model	Model	NNP
cord-000947-psguw47w	209	2	II	II	NNP
cord-000947-psguw47w	209	3	is	be	VBZ
cord-000947-psguw47w	209	4	shown	show	VBN
cord-000947-psguw47w	209	5	at	at	IN
cord-000947-psguw47w	209	6	right	right	NN
cord-000947-psguw47w	209	7	.	.	.
cord-000947-psguw47w	210	1	ScFv	ScFv	NNP
cord-000947-psguw47w	210	2	-	-	HYPH
cord-000947-psguw47w	210	3	A4	A4	NNP
cord-000947-psguw47w	210	4	is	be	VBZ
cord-000947-psguw47w	210	5	colored	color	VBN
cord-000947-psguw47w	210	6	in	in	IN
cord-000947-psguw47w	210	7	marine	marine	NN
cord-000947-psguw47w	210	8	.	.	.
cord-000947-psguw47w	211	1	HCK	HCK	NNP
cord-000947-psguw47w	211	2	is	be	VBZ
cord-000947-psguw47w	211	3	shown	show	VBN
cord-000947-psguw47w	211	4	as	as	IN
cord-000947-psguw47w	211	5	dimmer	dimmer	NN
cord-000947-psguw47w	211	6	.	.	.
cord-000947-psguw47w	212	1	One	one	CD
cord-000947-psguw47w	212	2	HCK	HCK	NNP
cord-000947-psguw47w	212	3	monomer	monomer	NN
cord-000947-psguw47w	212	4	is	be	VBZ
cord-000947-psguw47w	212	5	colored	color	VBN
cord-000947-psguw47w	212	6	in	in	IN
cord-000947-psguw47w	212	7	lime	lime	NN
cord-000947-psguw47w	212	8	.	.	.
cord-000947-psguw47w	213	1	The	the	DT
cord-000947-psguw47w	213	2	N	N	NNP
cord-000947-psguw47w	213	3	-	-	HYPH
cord-000947-psguw47w	213	4	terminal	terminal	NN
cord-000947-psguw47w	213	5	of	of	IN
cord-000947-psguw47w	213	6	the	the	DT
cord-000947-psguw47w	213	7	other	other	JJ
cord-000947-psguw47w	213	8	HCK	HCK	NNP
cord-000947-psguw47w	213	9	monomer	monomer	NN
cord-000947-psguw47w	213	10	is	be	VBZ
cord-000947-psguw47w	213	11	colored	color	VBN
cord-000947-psguw47w	213	12	in	in	IN
cord-000947-psguw47w	213	13	slate	slate	NN
cord-000947-psguw47w	213	14	and	and	CC
cord-000947-psguw47w	213	15	C	c	NN
cord-000947-psguw47w	213	16	-	-	HYPH
cord-000947-psguw47w	213	17	terminal	terminal	NN
cord-000947-psguw47w	213	18	in	in	IN
cord-000947-psguw47w	213	19	cyan	cyan	NNP
cord-000947-psguw47w	213	20	,	,	,
cord-000947-psguw47w	213	21	the	the	DT
cord-000947-psguw47w	213	22	linker	linker	NN
cord-000947-psguw47w	213	23	is	be	VBZ
cord-000947-psguw47w	213	24	colored	color	VBN
cord-000947-psguw47w	213	25	in	in	IN
cord-000947-psguw47w	213	26	orange	orange	NN
cord-000947-psguw47w	213	27	.	.	.
cord-000947-psguw47w	214	1	The	the	DT
cord-000947-psguw47w	214	2	V8	V8	NNP
cord-000947-psguw47w	214	3	endoproteinase	endoproteinase	NN
cord-000947-psguw47w	214	4	sensitive	sensitive	JJ
cord-000947-psguw47w	214	5	fragment	fragment	NN
cord-000947-psguw47w	214	6	is	be	VBZ
cord-000947-psguw47w	214	7	colored	color	VBN
cord-000947-psguw47w	214	8	in	in	IN
cord-000947-psguw47w	214	9	magentas	magenta	NNS
cord-000947-psguw47w	214	10	.	.	.
cord-000947-psguw47w	215	1	The	the	DT
cord-000947-psguw47w	215	2	binding	bind	VBG
cord-000947-psguw47w	215	3	residues	residue	NNS
cord-000947-psguw47w	215	4	are	be	VBP
cord-000947-psguw47w	215	5	represented	represent	VBN
cord-000947-psguw47w	215	6	by	by	IN
cord-000947-psguw47w	215	7	using	use	VBG
cord-000947-psguw47w	215	8	the	the	DT
cord-000947-psguw47w	215	9	stick	stick	NNP
cord-000947-psguw47w	215	10	model	model	NN
cord-000947-psguw47w	215	11	.	.	.
cord-000947-psguw47w	216	1	The	the	DT
cord-000947-psguw47w	216	2	PHE250	PHE250	NNP
cord-000947-psguw47w	216	3	,	,	,
cord-000947-psguw47w	216	4	VAL347	VAL347	NNP
cord-000947-psguw47w	216	5	are	be	VBP
cord-000947-psguw47w	216	6	represented	represent	VBN
cord-000947-psguw47w	216	7	using	use	VBG
cord-000947-psguw47w	216	8	the	the	DT
cord-000947-psguw47w	216	9	sphere	sphere	JJ
cord-000947-psguw47w	216	10	model	model	NN
cord-000947-psguw47w	216	11	.	.	.
cord-000947-psguw47w	217	1	doi:10.1371	doi:10.1371	NNP
cord-000947-psguw47w	217	2	/	/	SYM
cord-000947-psguw47w	217	3	journal.pone.0062147.g005	journal.pone.0062147.g005	NNP
cord-000947-psguw47w	217	4	Chaperone	Chaperone	NNP
cord-000947-psguw47w	217	5	-	-	HYPH
cord-000947-psguw47w	217	6	like	like	JJ
cord-000947-psguw47w	217	7	Function	function	NN
cord-000947-psguw47w	217	8	of	of	IN
cord-000947-psguw47w	217	9	an	an	DT
cord-000947-psguw47w	217	10	scFv	scfv	JJ
cord-000947-psguw47w	217	11	PLOS	PLOS	NNP
cord-000947-psguw47w	217	12	ONE	one	CD
cord-000947-psguw47w	217	13	|	|	NNP
cord-000947-psguw47w	217	14	www.plosone.org	www.plosone.org	NNP
cord-000947-psguw47w	217	15	Protein	Protein	NNP
cord-000947-psguw47w	217	16	aggregation	aggregation	NN
cord-000947-psguw47w	217	17	in	in	IN
cord-000947-psguw47w	217	18	disease	disease	NN
cord-000947-psguw47w	217	19	:	:	:
cord-000947-psguw47w	217	20	a	a	DT
cord-000947-psguw47w	217	21	role	role	NN
cord-000947-psguw47w	217	22	for	for	IN
cord-000947-psguw47w	217	23	folding	fold	VBG
cord-000947-psguw47w	217	24	intermediates	intermediate	NNS
cord-000947-psguw47w	217	25	forming	form	VBG
cord-000947-psguw47w	217	26	specific	specific	JJ
cord-000947-psguw47w	217	27	multimeric	multimeric	JJ
cord-000947-psguw47w	217	28	interactions	interaction	NNS
cord-000947-psguw47w	217	29	Targeting	target	VBG
cord-000947-psguw47w	217	30	misfolded	misfolded	JJ
cord-000947-psguw47w	217	31	proteins	protein	NNS
cord-000947-psguw47w	217	32	to	to	TO
cord-000947-psguw47w	217	33	fight	fight	VB
cord-000947-psguw47w	217	34	neurodegenerative	neurodegenerative	JJ
cord-000947-psguw47w	217	35	diseases	disease	NNS
cord-000947-psguw47w	217	36	Molecular	Molecular	NNP
cord-000947-psguw47w	217	37	chaperones	chaperone	NNS
cord-000947-psguw47w	217	38	:	:	:
cord-000947-psguw47w	217	39	proteins	protein	NNS
cord-000947-psguw47w	217	40	essential	essential	JJ
cord-000947-psguw47w	217	41	for	for	IN
cord-000947-psguw47w	217	42	the	the	DT
cord-000947-psguw47w	217	43	biogenesis	biogenesis	NN
cord-000947-psguw47w	217	44	of	of	IN
cord-000947-psguw47w	217	45	some	some	DT
cord-000947-psguw47w	217	46	macromolecular	macromolecular	JJ
cord-000947-psguw47w	217	47	structures	structure	NNS
cord-000947-psguw47w	217	48	Molecular	Molecular	NNP
cord-000947-psguw47w	217	49	chaperones	chaperone	NNS
cord-000947-psguw47w	217	50	:	:	:
cord-000947-psguw47w	217	51	assisting	assist	VBG
cord-000947-psguw47w	217	52	assembly	assembly	NN
cord-000947-psguw47w	217	53	in	in	IN
cord-000947-psguw47w	217	54	addition	addition	NN
cord-000947-psguw47w	217	55	to	to	IN
cord-000947-psguw47w	217	56	folding	fold	VBG
cord-000947-psguw47w	217	57	Effects	effect	NNS
cord-000947-psguw47w	217	58	of	of	IN
cord-000947-psguw47w	217	59	the	the	DT
cord-000947-psguw47w	217	60	single	single	JJ
cord-000947-psguw47w	217	61	point	point	NN
cord-000947-psguw47w	217	62	genetic	genetic	JJ
cord-000947-psguw47w	217	63	mutation	mutation	NN
cord-000947-psguw47w	217	64	D54	D54	NNP
cord-000947-psguw47w	217	65	G	G	NNP
cord-000947-psguw47w	217	66	on	on	IN
cord-000947-psguw47w	217	67	muscle	muscle	NN
cord-000947-psguw47w	217	68	creatine	creatine	NN
cord-000947-psguw47w	217	69	kinase	kinase	NN
cord-000947-psguw47w	217	70	activity	activity	NN
cord-000947-psguw47w	217	71	,	,	,
cord-000947-psguw47w	217	72	structure	structure	NN
cord-000947-psguw47w	217	73	and	and	CC
cord-000947-psguw47w	217	74	stability	stability	NN
cord-000947-psguw47w	217	75	Autoantibodies	Autoantibodies	NNP
cord-000947-psguw47w	217	76	against	against	IN
cord-000947-psguw47w	217	77	chaperonin	chaperonin	NNS
cord-000947-psguw47w	217	78	CCT	CCT	NNP
cord-000947-psguw47w	217	79	in	in	IN
cord-000947-psguw47w	217	80	human	human	JJ
cord-000947-psguw47w	217	81	sera	sera	NNP
cord-000947-psguw47w	217	82	with	with	IN
cord-000947-psguw47w	217	83	rheumatic	rheumatic	JJ
cord-000947-psguw47w	217	84	autoimmune	autoimmune	JJ
cord-000947-psguw47w	217	85	diseases	disease	NNS
cord-000947-psguw47w	217	86	:	:	:
cord-000947-psguw47w	217	87	comparison	comparison	NN
cord-000947-psguw47w	217	88	with	with	IN
cord-000947-psguw47w	217	89	antibodies	antibody	NNS
cord-000947-psguw47w	217	90	against	against	IN
cord-000947-psguw47w	217	91	other	other	JJ
cord-000947-psguw47w	217	92	Hsp60	Hsp60	NNP
cord-000947-psguw47w	217	93	family	family	NN
cord-000947-psguw47w	217	94	proteins	protein	NNS
cord-000947-psguw47w	217	95	Heat	Heat	NNP
cord-000947-psguw47w	217	96	shock	shock	NN
cord-000947-psguw47w	217	97	protein	protein	NN
cord-000947-psguw47w	217	98	90	90	CD
cord-000947-psguw47w	217	99	:	:	:
cord-000947-psguw47w	217	100	the	the	DT
cord-000947-psguw47w	217	101	cancer	cancer	NN
cord-000947-psguw47w	217	102	chaperone	chaperone	NN
cord-000947-psguw47w	217	103	.	.	.
cord-000947-psguw47w	218	1	Heat	heat	NN
cord-000947-psguw47w	218	2	Shock	shock	NN
cord-000947-psguw47w	218	3	Proteins	protein	NNS
cord-000947-psguw47w	218	4	in	in	IN
cord-000947-psguw47w	218	5	Cancer	cancer	NN
cord-000947-psguw47w	218	6	Therapeutic	therapeutic	JJ
cord-000947-psguw47w	218	7	approaches	approach	NNS
cord-000947-psguw47w	218	8	to	to	IN
cord-000947-psguw47w	218	9	protein	protein	NN
cord-000947-psguw47w	218	10	-	-	HYPH
cord-000947-psguw47w	218	11	misfolding	misfolde	VBG
cord-000947-psguw47w	218	12	diseases	disease	NNS
cord-000947-psguw47w	218	13	Antibodies	antibody	NNS
cord-000947-psguw47w	218	14	as	as	IN
cord-000947-psguw47w	218	15	specific	specific	JJ
cord-000947-psguw47w	218	16	chaperones	chaperone	NNS
cord-000947-psguw47w	218	17	Delayed	delay	VBN
cord-000947-psguw47w	218	18	-	-	HYPH
cord-000947-psguw47w	218	19	onset	onset	NN
cord-000947-psguw47w	218	20	muscle	muscle	NN
cord-000947-psguw47w	218	21	soreness	soreness	NN
cord-000947-psguw47w	218	22	does	do	VBZ
cord-000947-psguw47w	218	23	not	not	RB
cord-000947-psguw47w	218	24	reflect	reflect	VB
cord-000947-psguw47w	218	25	the	the	DT
cord-000947-psguw47w	218	26	magnitude	magnitude	NN
cord-000947-psguw47w	218	27	of	of	IN
cord-000947-psguw47w	218	28	eccentric	eccentric	JJ
cord-000947-psguw47w	218	29	exercise	exercise	NN
cord-000947-psguw47w	218	30	-	-	HYPH
cord-000947-psguw47w	218	31	induced	induce	VBN
cord-000947-psguw47w	218	32	muscle	muscle	NN
cord-000947-psguw47w	218	33	damage	damage	NN
cord-000947-psguw47w	218	34	.	.	.
cord-000947-psguw47w	219	1	Scandinavian	scandinavian	JJ
cord-000947-psguw47w	219	2	journal	journal	NN
cord-000947-psguw47w	219	3	of	of	IN
cord-000947-psguw47w	219	4	medicine	medicine	NNP
cord-000947-psguw47w	220	1	The	the	DT
cord-000947-psguw47w	220	2	Creatine	Creatine	NNP
cord-000947-psguw47w	220	3	Kinase	Kinase	NNP
cord-000947-psguw47w	220	4	/	/	SYM
cord-000947-psguw47w	220	5	Creatine	Creatine	NNP
cord-000947-psguw47w	220	6	Connection	connection	NN
cord-000947-psguw47w	220	7	to	to	IN
cord-000947-psguw47w	220	8	Alzheimer	Alzheimer	NNP
cord-000947-psguw47w	220	9	's	's	POS
cord-000947-psguw47w	220	10	Disease	Disease	NNP
cord-000947-psguw47w	220	11	:	:	:
cord-000947-psguw47w	220	12	CK	CK	NNP
cord-000947-psguw47w	220	13	Inactivation	Inactivation	NNP
cord-000947-psguw47w	220	14	,	,	,
cord-000947-psguw47w	220	15	APP	APP	NNP
cord-000947-psguw47w	220	16	-	-	HYPH
cord-000947-psguw47w	220	17	CK	CK	NNP
cord-000947-psguw47w	220	18	Complexes	Complexes	NNPS
cord-000947-psguw47w	220	19	and	and	CC
cord-000947-psguw47w	220	20	Focal	Focal	NNP
cord-000947-psguw47w	220	21	Creatine	Creatine	NNP
cord-000947-psguw47w	220	22	Deposits	deposit	NNS
cord-000947-psguw47w	220	23	Mitochondrial	mitochondrial	IN
cord-000947-psguw47w	220	24	creatine	creatine	NN
cord-000947-psguw47w	220	25	kinase	kinase	NN
cord-000947-psguw47w	220	26	in	in	IN
cord-000947-psguw47w	220	27	human	human	JJ
cord-000947-psguw47w	220	28	health	health	NN
cord-000947-psguw47w	220	29	and	and	CC
cord-000947-psguw47w	220	30	disease	disease	NN
cord-000947-psguw47w	221	1	A	a	DT
cord-000947-psguw47w	221	2	scFv	scfv	JJ
cord-000947-psguw47w	221	3	antibody	antibody	NN
cord-000947-psguw47w	221	4	against	against	IN
cord-000947-psguw47w	221	5	human	human	JJ
cord-000947-psguw47w	221	6	muscle	muscle	NN
cord-000947-psguw47w	221	7	creatine	creatine	NN
cord-000947-psguw47w	221	8	kinase	kinase	NN
cord-000947-psguw47w	221	9	as	as	IN
cord-000947-psguw47w	221	10	fully	fully	RB
cord-000947-psguw47w	221	11	functional	functional	JJ
cord-000947-psguw47w	221	12	chaperone	chaperone	NN
cord-000947-psguw47w	222	1	The	the	DT
cord-000947-psguw47w	222	2	selection	selection	NN
cord-000947-psguw47w	222	3	of	of	IN
cord-000947-psguw47w	222	4	intracellular	intracellular	JJ
cord-000947-psguw47w	222	5	antibodies	antibody	NNS
cord-000947-psguw47w	222	6	Design	design	NN
cord-000947-psguw47w	222	7	and	and	CC
cord-000947-psguw47w	222	8	use	use	NN
cord-000947-psguw47w	222	9	of	of	IN
cord-000947-psguw47w	222	10	a	a	DT
cord-000947-psguw47w	222	11	phage	phage	NN
cord-000947-psguw47w	222	12	display	display	NN
cord-000947-psguw47w	222	13	library	library	NN
cord-000947-psguw47w	223	1	The	the	DT
cord-000947-psguw47w	223	2	use	use	NN
cord-000947-psguw47w	223	3	of	of	IN
cord-000947-psguw47w	223	4	phage	phage	NN
cord-000947-psguw47w	223	5	display	display	NN
cord-000947-psguw47w	223	6	for	for	IN
cord-000947-psguw47w	223	7	the	the	DT
cord-000947-psguw47w	223	8	development	development	NN
cord-000947-psguw47w	223	9	of	of	IN
cord-000947-psguw47w	223	10	tumour	tumour	NN
cord-000947-psguw47w	223	11	targeting	target	VBG
cord-000947-psguw47w	223	12	agents	agent	NNS
cord-000947-psguw47w	223	13	Isolation	isolation	NN
cord-000947-psguw47w	223	14	of	of	IN
cord-000947-psguw47w	223	15	high	high	JJ
cord-000947-psguw47w	223	16	affinity	affinity	NN
cord-000947-psguw47w	223	17	human	human	JJ
cord-000947-psguw47w	223	18	antibodies	antibody	NNS
cord-000947-psguw47w	223	19	directly	directly	RB
cord-000947-psguw47w	223	20	from	from	IN
cord-000947-psguw47w	223	21	large	large	JJ
cord-000947-psguw47w	223	22	synthetic	synthetic	JJ
cord-000947-psguw47w	223	23	repertoires	repertoire	NNS
cord-000947-psguw47w	223	24	Isoenzyme	Isoenzyme	NNP
cord-000947-psguw47w	223	25	-	-	HYPH
cord-000947-psguw47w	223	26	directed	direct	VBN
cord-000947-psguw47w	223	27	selection	selection	NN
cord-000947-psguw47w	223	28	and	and	CC
cord-000947-psguw47w	223	29	characterization	characterization	NN
cord-000947-psguw47w	223	30	of	of	IN
cord-000947-psguw47w	223	31	anti	anti	JJ
cord-000947-psguw47w	223	32	-	-	JJ
cord-000947-psguw47w	223	33	creatine	creatine	JJ
cord-000947-psguw47w	223	34	kinase	kinase	NN
cord-000947-psguw47w	223	35	single	single	JJ
cord-000947-psguw47w	223	36	chain	chain	NN
cord-000947-psguw47w	223	37	Fv	Fv	NNP
cord-000947-psguw47w	223	38	antibodies	antibody	NNS
cord-000947-psguw47w	223	39	from	from	IN
cord-000947-psguw47w	223	40	a	a	DT
cord-000947-psguw47w	223	41	human	human	JJ
cord-000947-psguw47w	223	42	phage	phage	NN
cord-000947-psguw47w	223	43	display	display	NN
cord-000947-psguw47w	223	44	library	library	NN
cord-000947-psguw47w	223	45	Design	design	NN
cord-000947-psguw47w	223	46	,	,	,
cord-000947-psguw47w	223	47	structure	structure	NN
cord-000947-psguw47w	223	48	and	and	CC
cord-000947-psguw47w	223	49	stability	stability	NN
cord-000947-psguw47w	223	50	of	of	IN
cord-000947-psguw47w	223	51	a	a	DT
cord-000947-psguw47w	223	52	hyperthermophilic	hyperthermophilic	NN
cord-000947-psguw47w	223	53	protein	protein	NN
cord-000947-psguw47w	223	54	variant	variant	NN
cord-000947-psguw47w	223	55	Refolding	refolde	VBG
cord-000947-psguw47w	223	56	the	the	DT
cord-000947-psguw47w	223	57	engrailed	engrailed	NNP
cord-000947-psguw47w	223	58	homeodomain	homeodomain	NNP
cord-000947-psguw47w	223	59	:	:	:
cord-000947-psguw47w	224	1	Structural	structural	JJ
cord-000947-psguw47w	224	2	basis	basis	NN
cord-000947-psguw47w	224	3	for	for	IN
cord-000947-psguw47w	224	4	the	the	DT
cord-000947-psguw47w	224	5	accumulation	accumulation	NN
cord-000947-psguw47w	224	6	of	of	IN
cord-000947-psguw47w	224	7	a	a	DT
cord-000947-psguw47w	224	8	folding	fold	VBG
cord-000947-psguw47w	224	9	intermediate	intermediate	JJ
cord-000947-psguw47w	224	10	Automated	automate	VBN
cord-000947-psguw47w	224	11	design	design	NN
cord-000947-psguw47w	224	12	of	of	IN
cord-000947-psguw47w	224	13	specificity	specificity	NN
cord-000947-psguw47w	224	14	in	in	IN
cord-000947-psguw47w	224	15	molecular	molecular	JJ
cord-000947-psguw47w	224	16	recognition	recognition	NN
cord-000947-psguw47w	224	17	Computational	Computational	NNP
cord-000947-psguw47w	224	18	Design	Design	NNP
cord-000947-psguw47w	224	19	of	of	IN
cord-000947-psguw47w	224	20	a	a	DT
cord-000947-psguw47w	224	21	New	New	NNP
cord-000947-psguw47w	224	22	Hydrogen	Hydrogen	NNP
cord-000947-psguw47w	224	23	Bond	Bond	NNP
cord-000947-psguw47w	224	24	Network	Network	NNP
cord-000947-psguw47w	224	25	and	and	CC
cord-000947-psguw47w	224	26	at	at	IN
cord-000947-psguw47w	224	27	Least	Least	JJS
cord-000947-psguw47w	224	28	a	a	DT
cord-000947-psguw47w	224	29	300-fold	300-fold	CD
cord-000947-psguw47w	224	30	Specificity	Specificity	NNP
cord-000947-psguw47w	224	31	Switch	Switch	NNP
cord-000947-psguw47w	224	32	at	at	IN
cord-000947-psguw47w	224	33	a	a	DT
cord-000947-psguw47w	224	34	Protein	Protein	NNP
cord-000947-psguw47w	224	35	-	-	HYPH
cord-000947-psguw47w	224	36	Protein	Protein	NNP
cord-000947-psguw47w	224	37	Interface	Interface	NNP
cord-000947-psguw47w	224	38	Computational	Computational	NNP
cord-000947-psguw47w	224	39	design	design	NN
cord-000947-psguw47w	224	40	of	of	IN
cord-000947-psguw47w	224	41	second	second	JJ
cord-000947-psguw47w	224	42	-	-	HYPH
cord-000947-psguw47w	224	43	site	site	NN
cord-000947-psguw47w	224	44	suppressor	suppressor	NN
cord-000947-psguw47w	224	45	mutations	mutation	NNS
cord-000947-psguw47w	224	46	at	at	IN
cord-000947-psguw47w	224	47	protein	protein	NN
cord-000947-psguw47w	224	48	-	-	HYPH
cord-000947-psguw47w	224	49	protein	protein	NN
cord-000947-psguw47w	224	50	interfaces	interface	NNS
cord-000947-psguw47w	224	51	Computational	computational	JJ
cord-000947-psguw47w	224	52	design	design	NN
cord-000947-psguw47w	224	53	of	of	IN
cord-000947-psguw47w	224	54	affinity	affinity	NN
cord-000947-psguw47w	224	55	and	and	CC
cord-000947-psguw47w	224	56	specificity	specificity	NN
cord-000947-psguw47w	224	57	at	at	IN
cord-000947-psguw47w	224	58	protein	protein	NN
cord-000947-psguw47w	224	59	-	-	HYPH
cord-000947-psguw47w	224	60	protein	protein	NN
cord-000947-psguw47w	224	61	interfaces	interface	NNS
cord-000947-psguw47w	225	1	Hsp90/	hsp90/	NN
cord-000947-psguw47w	226	1	Cdc37	Cdc37	NNP
cord-000947-psguw47w	226	2	Chaperone	Chaperone	NNP
cord-000947-psguw47w	226	3	/	/	SYM
cord-000947-psguw47w	226	4	co	co	JJ
cord-000947-psguw47w	226	5	-	-	NN
cord-000947-psguw47w	226	6	chaperone	chaperone	JJ
cord-000947-psguw47w	226	7	complex	complex	NN
cord-000947-psguw47w	226	8	,	,	,
cord-000947-psguw47w	226	9	a	a	DT
cord-000947-psguw47w	226	10	novel	novel	JJ
cord-000947-psguw47w	226	11	junction	junction	NN
cord-000947-psguw47w	226	12	anticancer	anticancer	JJ
cord-000947-psguw47w	226	13	target	target	NN
cord-000947-psguw47w	226	14	elucidated	elucidate	VBN
cord-000947-psguw47w	226	15	by	by	IN
cord-000947-psguw47w	226	16	the	the	DT
cord-000947-psguw47w	226	17	mode	mode	NN
cord-000947-psguw47w	226	18	of	of	IN
cord-000947-psguw47w	226	19	action	action	NN
cord-000947-psguw47w	226	20	of	of	IN
cord-000947-psguw47w	226	21	herbal	herbal	JJ
cord-000947-psguw47w	226	22	drug	drug	NN
cord-000947-psguw47w	227	1	Withaferin	Withaferin	NNP
cord-000947-psguw47w	227	2	A	A	NNP
cord-000947-psguw47w	228	1	Predicting	predict	VBG
cord-000947-psguw47w	228	2	flexible	flexible	JJ
cord-000947-psguw47w	228	3	length	length	NN
cord-000947-psguw47w	228	4	linear	linear	JJ
cord-000947-psguw47w	228	5	B	b	NN
cord-000947-psguw47w	228	6	-	-	HYPH
cord-000947-psguw47w	228	7	cell	cell	NN
cord-000947-psguw47w	228	8	epitopes	epitope	NNS
cord-000947-psguw47w	228	9	Peptide	peptide	NN
cord-000947-psguw47w	228	10	microarrays	microarray	NNS
cord-000947-psguw47w	228	11	for	for	IN
cord-000947-psguw47w	228	12	the	the	DT
cord-000947-psguw47w	228	13	characterization	characterization	NN
cord-000947-psguw47w	228	14	of	of	IN
cord-000947-psguw47w	228	15	antigenic	antigenic	JJ
cord-000947-psguw47w	228	16	regions	region	NNS
cord-000947-psguw47w	228	17	of	of	IN
cord-000947-psguw47w	228	18	human	human	JJ
cord-000947-psguw47w	228	19	chromogranin	chromogranin	NNS
cord-000947-psguw47w	229	1	A	a	DT
cord-000947-psguw47w	229	2	AQUA	aqua	NN
cord-000947-psguw47w	229	3	and	and	CC
cord-000947-psguw47w	229	4	PROCHECK	PROCHECK	NNP
cord-000947-psguw47w	229	5	-	-	HYPH
cord-000947-psguw47w	229	6	NMR	NMR	NNP
cord-000947-psguw47w	229	7	:	:	:
cord-000947-psguw47w	229	8	programs	program	NNS
cord-000947-psguw47w	229	9	for	for	IN
cord-000947-psguw47w	229	10	checking	check	VBG
cord-000947-psguw47w	229	11	the	the	DT
cord-000947-psguw47w	229	12	quality	quality	NN
cord-000947-psguw47w	229	13	of	of	IN
cord-000947-psguw47w	229	14	protein	protein	NN
cord-000947-psguw47w	229	15	structures	structure	NNS
cord-000947-psguw47w	229	16	solved	solve	VBN
cord-000947-psguw47w	229	17	by	by	IN
cord-000947-psguw47w	229	18	NMR	NMR	NNP
cord-000947-psguw47w	229	19	A	A	NNP
cord-000947-psguw47w	229	20	method	method	NN
cord-000947-psguw47w	229	21	to	to	TO
cord-000947-psguw47w	229	22	identify	identify	VB
cord-000947-psguw47w	229	23	protein	protein	NN
cord-000947-psguw47w	229	24	sequences	sequence	NNS
cord-000947-psguw47w	229	25	that	that	WDT
cord-000947-psguw47w	229	26	fold	fold	VBP
cord-000947-psguw47w	229	27	into	into	IN
cord-000947-psguw47w	229	28	a	a	DT
cord-000947-psguw47w	229	29	known	know	VBN
cord-000947-psguw47w	229	30	three	three	CD
cord-000947-psguw47w	229	31	-	-	HYPH
cord-000947-psguw47w	229	32	dimensional	dimensional	JJ
cord-000947-psguw47w	229	33	structure	structure	NN
cord-000947-psguw47w	229	34	ElliPro	ElliPro	NNP
cord-000947-psguw47w	229	35	:	:	:
cord-000947-psguw47w	229	36	a	a	DT
cord-000947-psguw47w	229	37	new	new	JJ
cord-000947-psguw47w	229	38	structure	structure	NN
cord-000947-psguw47w	229	39	-	-	HYPH
cord-000947-psguw47w	229	40	based	base	VBN
cord-000947-psguw47w	229	41	tool	tool	NN
cord-000947-psguw47w	229	42	for	for	IN
cord-000947-psguw47w	229	43	the	the	DT
cord-000947-psguw47w	229	44	prediction	prediction	NN
cord-000947-psguw47w	229	45	of	of	IN
cord-000947-psguw47w	229	46	antibody	antibody	NN
cord-000947-psguw47w	229	47	epitopes	epitopes	NNP
cord-000947-psguw47w	230	1	ZDOCK	ZDOCK	NNP
cord-000947-psguw47w	230	2	:	:	:
cord-000947-psguw47w	231	1	An	an	DT
cord-000947-psguw47w	231	2	initial	initial	JJ
cord-000947-psguw47w	231	3	-	-	HYPH
cord-000947-psguw47w	231	4	stage	stage	NN
cord-000947-psguw47w	231	5	protein	protein	NN
cord-000947-psguw47w	231	6	docking	docking	NN
cord-000947-psguw47w	231	7	algorithm	algorithm	NN
cord-000947-psguw47w	231	8	Protein	protein	NN
cord-000947-psguw47w	231	9	-	-	HYPH
cord-000947-psguw47w	231	10	protein	protein	NN
cord-000947-psguw47w	231	11	docking	docking	NN
cord-000947-psguw47w	231	12	with	with	IN
cord-000947-psguw47w	231	13	simultaneous	simultaneous	JJ
cord-000947-psguw47w	231	14	optimization	optimization	NN
cord-000947-psguw47w	231	15	of	of	IN
cord-000947-psguw47w	231	16	rigid	rigid	JJ
cord-000947-psguw47w	231	17	-	-	HYPH
cord-000947-psguw47w	231	18	body	body	NN
cord-000947-psguw47w	231	19	displacement	displacement	NN
cord-000947-psguw47w	231	20	and	and	CC
cord-000947-psguw47w	231	21	side	side	NN
cord-000947-psguw47w	231	22	-	-	HYPH
cord-000947-psguw47w	231	23	chain	chain	NN
cord-000947-psguw47w	231	24	conformations	conformation	NNS
cord-000947-psguw47w	231	25	Conformational	Conformational	NNP
cord-000947-psguw47w	231	26	change	change	NN
cord-000947-psguw47w	231	27	in	in	IN
cord-000947-psguw47w	231	28	the	the	DT
cord-000947-psguw47w	231	29	Cterminal	Cterminal	NNP
cord-000947-psguw47w	231	30	domain	domain	NN
cord-000947-psguw47w	231	31	is	be	VBZ
cord-000947-psguw47w	231	32	responsible	responsible	JJ
cord-000947-psguw47w	231	33	for	for	IN
cord-000947-psguw47w	231	34	the	the	DT
cord-000947-psguw47w	231	35	initiation	initiation	NN
cord-000947-psguw47w	231	36	of	of	IN
cord-000947-psguw47w	231	37	creatine	creatine	NN
cord-000947-psguw47w	231	38	kinase	kinase	NN
cord-000947-psguw47w	231	39	thermal	thermal	JJ
cord-000947-psguw47w	231	40	aggregation	aggregation	NN
cord-000947-psguw47w	231	41	Role	role	NN
cord-000947-psguw47w	231	42	of	of	IN
cord-000947-psguw47w	231	43	the	the	DT
cord-000947-psguw47w	231	44	linker	linker	NN
cord-000947-psguw47w	231	45	between	between	IN
cord-000947-psguw47w	231	46	the	the	DT
cord-000947-psguw47w	231	47	N	N	NNP
cord-000947-psguw47w	231	48	-	-	HYPH
cord-000947-psguw47w	231	49	and	and	CC
cord-000947-psguw47w	231	50	C	c	NN
cord-000947-psguw47w	231	51	-	-	HYPH
cord-000947-psguw47w	231	52	terminal	terminal	NN
cord-000947-psguw47w	231	53	domains	domain	NNS
cord-000947-psguw47w	231	54	in	in	IN
cord-000947-psguw47w	231	55	the	the	DT
cord-000947-psguw47w	231	56	stability	stability	NN
cord-000947-psguw47w	231	57	and	and	CC
cord-000947-psguw47w	231	58	folding	folding	NN
cord-000947-psguw47w	231	59	of	of	IN
cord-000947-psguw47w	231	60	rabbit	rabbit	NN
cord-000947-psguw47w	231	61	muscle	muscle	NN
cord-000947-psguw47w	231	62	creatine	creatine	NN
cord-000947-psguw47w	231	63	kinase	kinase	NNP
cord-000947-psguw47w	231	64	Mutation	Mutation	NNP
cord-000947-psguw47w	231	65	of	of	IN
cord-000947-psguw47w	231	66	the	the	DT
cord-000947-psguw47w	231	67	conserved	conserved	JJ
cord-000947-psguw47w	231	68	Asp122	Asp122	NFP
cord-000947-psguw47w	231	69	in	in	IN
cord-000947-psguw47w	231	70	the	the	DT
cord-000947-psguw47w	231	71	linker	linker	NN
cord-000947-psguw47w	231	72	impedes	impede	VBZ
cord-000947-psguw47w	231	73	creatine	creatine	NN
cord-000947-psguw47w	231	74	kinase	kinase	NN
cord-000947-psguw47w	231	75	reactivation	reactivation	NN
cord-000947-psguw47w	231	76	and	and	CC
cord-000947-psguw47w	231	77	refolding	refolde	VBG
cord-000947-psguw47w	231	78	Chaperone	Chaperone	NNP
cord-000947-psguw47w	231	79	-	-	HYPH
cord-000947-psguw47w	231	80	Like	Like	NNP
cord-000947-psguw47w	231	81	Effect	Effect	NNP
cord-000947-psguw47w	231	82	of	of	IN
cord-000947-psguw47w	231	83	the	the	DT
cord-000947-psguw47w	231	84	Linker	Linker	NNP
cord-000947-psguw47w	231	85	on	on	IN
cord-000947-psguw47w	231	86	the	the	DT
cord-000947-psguw47w	231	87	Isolated	Isolated	NNP
cord-000947-psguw47w	231	88	C	C	NNP
cord-000947-psguw47w	231	89	-	-	HYPH
cord-000947-psguw47w	231	90	Terminal	Terminal	NNP
cord-000947-psguw47w	231	91	Domain	Domain	NNP
cord-000947-psguw47w	231	92	of	of	IN
cord-000947-psguw47w	231	93	Rabbit	Rabbit	NNP
cord-000947-psguw47w	231	94	Muscle	Muscle	NNP
cord-000947-psguw47w	231	95	Creatine	Creatine	NNP
cord-000947-psguw47w	231	96	Kinase	Kinase	NNP
cord-000947-psguw47w	231	97	Protease	Protease	NNP
cord-000947-psguw47w	231	98	digestion	digestion	NN
cord-000947-psguw47w	231	99	studies	study	NNS
cord-000947-psguw47w	231	100	of	of	IN
cord-000947-psguw47w	231	101	an	an	DT
cord-000947-psguw47w	231	102	equilibrium	equilibrium	NN
cord-000947-psguw47w	231	103	intermediate	intermediate	JJ
cord-000947-psguw47w	231	104	in	in	IN
cord-000947-psguw47w	231	105	the	the	DT
cord-000947-psguw47w	231	106	unfolding	unfolding	NN
cord-000947-psguw47w	231	107	of	of	IN
cord-000947-psguw47w	231	108	creatine	creatine	NN
cord-000947-psguw47w	231	109	kinase	kinase	NN
cord-000947-psguw47w	231	110	The	the	DT
cord-000947-psguw47w	231	111	tryptophan	tryptophan	NN
cord-000947-psguw47w	231	112	residues	residue	NNS
cord-000947-psguw47w	231	113	of	of	IN
cord-000947-psguw47w	231	114	mitochondrial	mitochondrial	JJ
cord-000947-psguw47w	231	115	creatine	creatine	NN
cord-000947-psguw47w	231	116	kinase	kinase	NN
cord-000947-psguw47w	231	117	:	:	:
cord-000947-psguw47w	231	118	Roles	role	NNS
cord-000947-psguw47w	231	119	of	of	IN
cord-000947-psguw47w	231	120	Trp-223	Trp-223	NNP
cord-000947-psguw47w	231	121	,	,	,
cord-000947-psguw47w	231	122	Trp-206	Trp-206	NNP
cord-000947-psguw47w	231	123	,	,	,
cord-000947-psguw47w	231	124	and	and	CC
cord-000947-psguw47w	231	125	Trp-264	Trp-264	NNP
cord-000947-psguw47w	231	126	in	in	IN
cord-000947-psguw47w	231	127	active	active	JJ
cord-000947-psguw47w	231	128	-	-	HYPH
cord-000947-psguw47w	231	129	site	site	NN
cord-000947-psguw47w	231	130	and	and	CC
cord-000947-psguw47w	231	131	quaternary	quaternary	JJ
cord-000947-psguw47w	231	132	structure	structure	NN
cord-000947-psguw47w	231	133	formation	formation	NN
cord-000947-psguw47w	231	134	Monoclonal	Monoclonal	NNP
cord-000947-psguw47w	231	135	antibody	antibody	NN
cord-000947-psguw47w	231	136	studies	study	NNS
cord-000947-psguw47w	231	137	suggest	suggest	VBP
cord-000947-psguw47w	231	138	a	a	DT
cord-000947-psguw47w	231	139	catalytic	catalytic	JJ
cord-000947-psguw47w	231	140	site	site	NN
cord-000947-psguw47w	231	141	at	at	IN
cord-000947-psguw47w	231	142	the	the	DT
cord-000947-psguw47w	231	143	interface	interface	NN
cord-000947-psguw47w	231	144	between	between	IN
cord-000947-psguw47w	231	145	domains	domain	NNS
cord-000947-psguw47w	231	146	in	in	IN
cord-000947-psguw47w	231	147	creatine	creatine	NN
cord-000947-psguw47w	231	148	kinase	kinase	NN
cord-000947-psguw47w	231	149	Neutralizing	neutralize	VBG
cord-000947-psguw47w	231	150	antibodies	antibody	NNS
cord-000947-psguw47w	231	151	of	of	IN
cord-000947-psguw47w	231	152	botulinum	botulinum	NN
cord-000947-psguw47w	231	153	neurotoxin	neurotoxin	NN
cord-000947-psguw47w	231	154	serotype	serotype	NN
cord-000947-psguw47w	231	155	A	a	DT
cord-000947-psguw47w	231	156	screened	screen	VBN
cord-000947-psguw47w	231	157	from	from	IN
cord-000947-psguw47w	231	158	a	a	DT
cord-000947-psguw47w	231	159	fully	fully	RB
cord-000947-psguw47w	231	160	synthetic	synthetic	JJ
cord-000947-psguw47w	231	161	human	human	JJ
cord-000947-psguw47w	231	162	antibody	antibody	NN
cord-000947-psguw47w	231	163	phage	phage	NN
cord-000947-psguw47w	231	164	display	display	NN
cord-000947-psguw47w	231	165	library	library	NN
cord-000947-psguw47w	231	166	Multiple	multiple	JJ
cord-000947-psguw47w	231	167	sequence	sequence	NN
cord-000947-psguw47w	231	168	alignment	alignment	NN
cord-000947-psguw47w	231	169	using	use	VBG
cord-000947-psguw47w	231	170	ClustalW	clustalw	RBS
cord-000947-psguw47w	231	171	and	and	CC
cord-000947-psguw47w	231	172	ClustalX	ClustalX	``
cord-000947-psguw47w	231	173	The	the	DT
cord-000947-psguw47w	231	174	protein	protein	NN
cord-000947-psguw47w	231	175	data	datum	NNS
cord-000947-psguw47w	231	176	bank	bank	NN
cord-000947-psguw47w	231	177	Structure	Structure	NNP
cord-000947-psguw47w	231	178	of	of	IN
cord-000947-psguw47w	231	179	severe	severe	JJ
cord-000947-psguw47w	231	180	acute	acute	JJ
cord-000947-psguw47w	231	181	respiratory	respiratory	JJ
cord-000947-psguw47w	231	182	syndrome	syndrome	NN
cord-000947-psguw47w	231	183	coronavirus	coronavirus	NN
cord-000947-psguw47w	231	184	receptor	receptor	NN
cord-000947-psguw47w	231	185	-	-	HYPH
cord-000947-psguw47w	231	186	binding	bind	VBG
cord-000947-psguw47w	231	187	domain	domain	NN
cord-000947-psguw47w	231	188	complexed	complexe	VBN
cord-000947-psguw47w	231	189	with	with	IN
cord-000947-psguw47w	231	190	neutralizing	neutralize	VBG
cord-000947-psguw47w	231	191	antibody	antibody	NN
cord-000947-psguw47w	231	192	Comparative	comparative	JJ
cord-000947-psguw47w	231	193	protein	protein	NN
cord-000947-psguw47w	231	194	structure	structure	NN
cord-000947-psguw47w	231	195	modeling	modeling	NN
cord-000947-psguw47w	231	196	using	use	VBG
cord-000947-psguw47w	231	197	Modeller	Modeller	NNP
cord-000947-psguw47w	231	198	Sequences	Sequences	NNPS
cord-000947-psguw47w	231	199	of	of	IN
cord-000947-psguw47w	231	200	proteins	protein	NNS
cord-000947-psguw47w	231	201	of	of	IN
cord-000947-psguw47w	231	202	immunological	immunological	JJ
cord-000947-psguw47w	231	203	interest	interest	NN
cord-000947-psguw47w	231	204	:	:	:
cord-000947-psguw47w	231	205	US	US	NNP
cord-000947-psguw47w	231	206	Dept	Dept	NNP
cord-000947-psguw47w	231	207	.	.	NNP
cord-000947-psguw47w	231	208	of	of	IN
cord-000947-psguw47w	231	209	Health	Health	NNP
cord-000947-psguw47w	231	210	and	and	CC
cord-000947-psguw47w	231	211	Human	Human	NNP
cord-000947-psguw47w	231	212	Services	Services	NNPS
cord-000947-psguw47w	231	213	Structure	Structure	NNP
cord-000947-psguw47w	231	214	of	of	IN
cord-000947-psguw47w	231	215	human	human	JJ
cord-000947-psguw47w	231	216	muscle	muscle	NN
cord-000947-psguw47w	231	217	creatine	creatine	NN
cord-000947-psguw47w	231	218	kinase	kinase	NNP