id sid tid token lemma pos cord-000580-dcid9emx 1 1 key key JJ cord-000580-dcid9emx 2 1 : : : cord-000580-dcid9emx 2 2 cord-000580-dcid9emx cord-000580-dcid9emx NNP cord-000580-dcid9emx 2 3 authors author NNS cord-000580-dcid9emx 2 4 : : : cord-000580-dcid9emx 2 5 Sällman Sällman NNP cord-000580-dcid9emx 2 6 Almén Almén NNP cord-000580-dcid9emx 2 7 , , , cord-000580-dcid9emx 2 8 Markus Markus NNP cord-000580-dcid9emx 2 9 ; ; : cord-000580-dcid9emx 2 10 Bringeland Bringeland NNP cord-000580-dcid9emx 2 11 , , , cord-000580-dcid9emx 2 12 Nathalie Nathalie NNP cord-000580-dcid9emx 2 13 ; ; : cord-000580-dcid9emx 2 14 Fredriksson Fredriksson NNP cord-000580-dcid9emx 2 15 , , , cord-000580-dcid9emx 2 16 Robert Robert NNP cord-000580-dcid9emx 2 17 ; ; : cord-000580-dcid9emx 2 18 Schiöth Schiöth NNP cord-000580-dcid9emx 2 19 , , , cord-000580-dcid9emx 2 20 Helgi Helgi NNP cord-000580-dcid9emx 2 21 B. B. NNP cord-000580-dcid9emx 2 22 title title NN cord-000580-dcid9emx 2 23 : : : cord-000580-dcid9emx 2 24 The the DT cord-000580-dcid9emx 2 25 Dispanins Dispanins NNPS cord-000580-dcid9emx 2 26 : : : cord-000580-dcid9emx 2 27 A a DT cord-000580-dcid9emx 2 28 Novel Novel NNP cord-000580-dcid9emx 2 29 Gene Gene NNP cord-000580-dcid9emx 2 30 Family Family NNP cord-000580-dcid9emx 2 31 of of IN cord-000580-dcid9emx 2 32 Ancient Ancient NNP cord-000580-dcid9emx 2 33 Origin Origin NNP cord-000580-dcid9emx 3 1 That that DT cord-000580-dcid9emx 3 2 Contains contain VBZ cord-000580-dcid9emx 3 3 14 14 CD cord-000580-dcid9emx 3 4 Human Human NNP cord-000580-dcid9emx 3 5 Members Members NNPS cord-000580-dcid9emx 3 6 date date NN cord-000580-dcid9emx 4 1 : : : cord-000580-dcid9emx 4 2 2012 2012 CD cord-000580-dcid9emx 4 3 - - SYM cord-000580-dcid9emx 4 4 02 02 CD cord-000580-dcid9emx 4 5 - - SYM cord-000580-dcid9emx 4 6 20 20 CD cord-000580-dcid9emx 4 7 journal journal NN cord-000580-dcid9emx 4 8 : : : cord-000580-dcid9emx 5 1 PLoS PLoS NNP cord-000580-dcid9emx 5 2 One one CD cord-000580-dcid9emx 5 3 DOI DOI NNP cord-000580-dcid9emx 5 4 : : : cord-000580-dcid9emx 5 5 10.1371 10.1371 CD cord-000580-dcid9emx 5 6 / / SYM cord-000580-dcid9emx 5 7 journal.pone.0031961 journal.pone.0031961 NNP cord-000580-dcid9emx 5 8 sha sha NNP cord-000580-dcid9emx 5 9 : : : cord-000580-dcid9emx 5 10 7e889eb3dc54b352c2689b84be7a52f121f80b56 7e889eb3dc54b352c2689b84be7a52f121f80b56 CD cord-000580-dcid9emx 5 11 doc_id doc_id CD cord-000580-dcid9emx 5 12 : : : cord-000580-dcid9emx 5 13 580 580 CD cord-000580-dcid9emx 5 14 cord_uid cord_uid NN cord-000580-dcid9emx 5 15 : : : cord-000580-dcid9emx 6 1 dcid9emx dcid9emx NNP cord-000580-dcid9emx 7 1 The the DT cord-000580-dcid9emx 7 2 Interferon Interferon NNP cord-000580-dcid9emx 7 3 induced induce VBD cord-000580-dcid9emx 7 4 transmembrane transmembrane NN cord-000580-dcid9emx 7 5 proteins protein NNS cord-000580-dcid9emx 7 6 ( ( -LRB- cord-000580-dcid9emx 7 7 IFITM IFITM NNP cord-000580-dcid9emx 7 8 ) ) -RRB- cord-000580-dcid9emx 7 9 are be VBP cord-000580-dcid9emx 7 10 a a DT cord-000580-dcid9emx 7 11 family family NN cord-000580-dcid9emx 7 12 of of IN cord-000580-dcid9emx 7 13 transmembrane transmembrane NN cord-000580-dcid9emx 7 14 proteins protein NNS cord-000580-dcid9emx 7 15 that that WDT cord-000580-dcid9emx 7 16 is be VBZ cord-000580-dcid9emx 7 17 known know VBN cord-000580-dcid9emx 7 18 to to TO cord-000580-dcid9emx 7 19 inhibit inhibit VB cord-000580-dcid9emx 7 20 cell cell NN cord-000580-dcid9emx 7 21 invasion invasion NN cord-000580-dcid9emx 7 22 of of IN cord-000580-dcid9emx 7 23 viruses virus NNS cord-000580-dcid9emx 7 24 such such JJ cord-000580-dcid9emx 7 25 as as IN cord-000580-dcid9emx 7 26 HIV-1 HIV-1 NNP cord-000580-dcid9emx 7 27 and and CC cord-000580-dcid9emx 7 28 influenza influenza NN cord-000580-dcid9emx 7 29 . . . cord-000580-dcid9emx 8 1 We -PRON- PRP cord-000580-dcid9emx 8 2 show show VBP cord-000580-dcid9emx 8 3 that that IN cord-000580-dcid9emx 8 4 the the DT cord-000580-dcid9emx 8 5 IFITM IFITM NNP cord-000580-dcid9emx 8 6 genes gene NNS cord-000580-dcid9emx 8 7 are be VBP cord-000580-dcid9emx 8 8 a a DT cord-000580-dcid9emx 8 9 subfamily subfamily NN cord-000580-dcid9emx 8 10 in in IN cord-000580-dcid9emx 8 11 a a DT cord-000580-dcid9emx 8 12 larger large JJR cord-000580-dcid9emx 8 13 family family NN cord-000580-dcid9emx 8 14 of of IN cord-000580-dcid9emx 8 15 transmembrane transmembrane NNP cord-000580-dcid9emx 8 16 ( ( -LRB- cord-000580-dcid9emx 8 17 TM TM NNP cord-000580-dcid9emx 8 18 ) ) -RRB- cord-000580-dcid9emx 8 19 proteins protein NNS cord-000580-dcid9emx 8 20 that that WDT cord-000580-dcid9emx 8 21 we -PRON- PRP cord-000580-dcid9emx 8 22 call call VBP cord-000580-dcid9emx 8 23 Dispanins Dispanins NNP cord-000580-dcid9emx 8 24 , , , cord-000580-dcid9emx 8 25 which which WDT cord-000580-dcid9emx 8 26 refers refer VBZ cord-000580-dcid9emx 8 27 to to IN cord-000580-dcid9emx 8 28 a a DT cord-000580-dcid9emx 8 29 common common JJ cord-000580-dcid9emx 8 30 2TM 2tm CD cord-000580-dcid9emx 8 31 structure structure NN cord-000580-dcid9emx 8 32 . . . cord-000580-dcid9emx 9 1 We -PRON- PRP cord-000580-dcid9emx 9 2 mined mine VBD cord-000580-dcid9emx 9 3 the the DT cord-000580-dcid9emx 9 4 Dispanins Dispanins NNPS cord-000580-dcid9emx 9 5 in in IN cord-000580-dcid9emx 9 6 36 36 CD cord-000580-dcid9emx 9 7 eukaryotic eukaryotic JJ cord-000580-dcid9emx 9 8 species specie NNS cord-000580-dcid9emx 9 9 , , , cord-000580-dcid9emx 9 10 covering cover VBG cord-000580-dcid9emx 9 11 all all DT cord-000580-dcid9emx 9 12 major major JJ cord-000580-dcid9emx 9 13 eukaryotic eukaryotic JJ cord-000580-dcid9emx 9 14 groups group NNS cord-000580-dcid9emx 9 15 , , , cord-000580-dcid9emx 9 16 and and CC cord-000580-dcid9emx 9 17 investigated investigate VBD cord-000580-dcid9emx 9 18 their -PRON- PRP$ cord-000580-dcid9emx 9 19 evolutionary evolutionary JJ cord-000580-dcid9emx 9 20 history history NN cord-000580-dcid9emx 9 21 using use VBG cord-000580-dcid9emx 9 22 Bayesian Bayesian NNP cord-000580-dcid9emx 9 23 and and CC cord-000580-dcid9emx 9 24 maximum maximum JJ cord-000580-dcid9emx 9 25 likelihood likelihood NN cord-000580-dcid9emx 9 26 approaches approach NNS cord-000580-dcid9emx 9 27 to to TO cord-000580-dcid9emx 9 28 infer infer VB cord-000580-dcid9emx 9 29 a a DT cord-000580-dcid9emx 9 30 phylogenetic phylogenetic JJ cord-000580-dcid9emx 9 31 tree tree NN cord-000580-dcid9emx 9 32 . . . cord-000580-dcid9emx 10 1 We -PRON- PRP cord-000580-dcid9emx 10 2 identified identify VBD cord-000580-dcid9emx 10 3 ten ten CD cord-000580-dcid9emx 10 4 human human JJ cord-000580-dcid9emx 10 5 genes gene NNS cord-000580-dcid9emx 10 6 that that WDT cord-000580-dcid9emx 10 7 together together RB cord-000580-dcid9emx 10 8 with with IN cord-000580-dcid9emx 10 9 the the DT cord-000580-dcid9emx 10 10 known know VBN cord-000580-dcid9emx 10 11 IFITM IFITM NNP cord-000580-dcid9emx 10 12 genes gene NNS cord-000580-dcid9emx 10 13 form form VBP cord-000580-dcid9emx 10 14 the the DT cord-000580-dcid9emx 10 15 Dispanin Dispanin NNP cord-000580-dcid9emx 10 16 family family NN cord-000580-dcid9emx 10 17 . . . cord-000580-dcid9emx 11 1 We -PRON- PRP cord-000580-dcid9emx 11 2 show show VBP cord-000580-dcid9emx 11 3 that that IN cord-000580-dcid9emx 11 4 the the DT cord-000580-dcid9emx 11 5 Dispanins Dispanins NNPS cord-000580-dcid9emx 11 6 first first RB cord-000580-dcid9emx 11 7 emerged emerge VBD cord-000580-dcid9emx 11 8 in in IN cord-000580-dcid9emx 11 9 eukaryotes eukaryote NNS cord-000580-dcid9emx 11 10 in in IN cord-000580-dcid9emx 11 11 a a DT cord-000580-dcid9emx 11 12 common common JJ cord-000580-dcid9emx 11 13 ancestor ancestor NN cord-000580-dcid9emx 11 14 of of IN cord-000580-dcid9emx 11 15 choanoflagellates choanoflagellate NNS cord-000580-dcid9emx 11 16 and and CC cord-000580-dcid9emx 11 17 metazoa metazoa NNP cord-000580-dcid9emx 11 18 , , , cord-000580-dcid9emx 11 19 and and CC cord-000580-dcid9emx 11 20 that that IN cord-000580-dcid9emx 11 21 the the DT cord-000580-dcid9emx 11 22 family family NN cord-000580-dcid9emx 11 23 later later RB cord-000580-dcid9emx 11 24 expanded expand VBD cord-000580-dcid9emx 11 25 in in IN cord-000580-dcid9emx 11 26 vertebrates vertebrate NNS cord-000580-dcid9emx 11 27 where where WRB cord-000580-dcid9emx 11 28 it -PRON- PRP cord-000580-dcid9emx 11 29 forms form VBZ cord-000580-dcid9emx 11 30 four four CD cord-000580-dcid9emx 11 31 subfamilies subfamily NNS cord-000580-dcid9emx 11 32 ( ( -LRB- cord-000580-dcid9emx 11 33 A a NN cord-000580-dcid9emx 11 34 – – : cord-000580-dcid9emx 11 35 D d NN cord-000580-dcid9emx 11 36 ) ) -RRB- cord-000580-dcid9emx 11 37 . . . cord-000580-dcid9emx 12 1 Interestingly interestingly RB cord-000580-dcid9emx 12 2 , , , cord-000580-dcid9emx 12 3 we -PRON- PRP cord-000580-dcid9emx 12 4 also also RB cord-000580-dcid9emx 12 5 find find VBP cord-000580-dcid9emx 12 6 that that IN cord-000580-dcid9emx 12 7 the the DT cord-000580-dcid9emx 12 8 family family NN cord-000580-dcid9emx 12 9 is be VBZ cord-000580-dcid9emx 12 10 found find VBN cord-000580-dcid9emx 12 11 in in IN cord-000580-dcid9emx 12 12 several several JJ cord-000580-dcid9emx 12 13 different different JJ cord-000580-dcid9emx 12 14 phyla phylum NNS cord-000580-dcid9emx 12 15 of of IN cord-000580-dcid9emx 12 16 bacteria bacteria NNS cord-000580-dcid9emx 12 17 and and CC cord-000580-dcid9emx 12 18 propose propose VB cord-000580-dcid9emx 12 19 that that IN cord-000580-dcid9emx 12 20 it -PRON- PRP cord-000580-dcid9emx 12 21 was be VBD cord-000580-dcid9emx 12 22 horizontally horizontally RB cord-000580-dcid9emx 12 23 transferred transfer VBN cord-000580-dcid9emx 12 24 to to IN cord-000580-dcid9emx 12 25 eukaryotes eukaryote NNS cord-000580-dcid9emx 12 26 from from IN cord-000580-dcid9emx 12 27 bacteria bacteria NNS cord-000580-dcid9emx 12 28 in in IN cord-000580-dcid9emx 12 29 the the DT cord-000580-dcid9emx 12 30 common common JJ cord-000580-dcid9emx 12 31 ancestor ancestor NN cord-000580-dcid9emx 12 32 of of IN cord-000580-dcid9emx 12 33 choanoflagellates choanoflagellates NNP cord-000580-dcid9emx 12 34 and and CC cord-000580-dcid9emx 12 35 metazoa metazoa NNP cord-000580-dcid9emx 12 36 . . . cord-000580-dcid9emx 13 1 The the DT cord-000580-dcid9emx 13 2 bacterial bacterial JJ cord-000580-dcid9emx 13 3 and and CC cord-000580-dcid9emx 13 4 eukaryotic eukaryotic JJ cord-000580-dcid9emx 13 5 sequences sequence NNS cord-000580-dcid9emx 13 6 have have VBP cord-000580-dcid9emx 13 7 a a DT cord-000580-dcid9emx 13 8 considerably considerably RB cord-000580-dcid9emx 13 9 conserved conserve VBN cord-000580-dcid9emx 13 10 protein protein NN cord-000580-dcid9emx 13 11 structure structure NN cord-000580-dcid9emx 13 12 . . . cord-000580-dcid9emx 14 1 In in IN cord-000580-dcid9emx 14 2 conclusion conclusion NN cord-000580-dcid9emx 14 3 , , , cord-000580-dcid9emx 14 4 we -PRON- PRP cord-000580-dcid9emx 14 5 introduce introduce VBP cord-000580-dcid9emx 14 6 a a DT cord-000580-dcid9emx 14 7 novel novel JJ cord-000580-dcid9emx 14 8 family family NN cord-000580-dcid9emx 14 9 , , , cord-000580-dcid9emx 14 10 the the DT cord-000580-dcid9emx 14 11 Dispanins Dispanins NNPS cord-000580-dcid9emx 14 12 , , , cord-000580-dcid9emx 14 13 together together RB cord-000580-dcid9emx 14 14 with with IN cord-000580-dcid9emx 14 15 a a DT cord-000580-dcid9emx 14 16 nomenclature nomenclature NN cord-000580-dcid9emx 14 17 based base VBN cord-000580-dcid9emx 14 18 on on IN cord-000580-dcid9emx 14 19 the the DT cord-000580-dcid9emx 14 20 evolutionary evolutionary JJ cord-000580-dcid9emx 14 21 origin origin NN cord-000580-dcid9emx 14 22 . . . cord-000580-dcid9emx 15 1 Membrane membrane NN cord-000580-dcid9emx 15 2 proteins protein NNS cord-000580-dcid9emx 15 3 are be VBP cord-000580-dcid9emx 15 4 essential essential JJ cord-000580-dcid9emx 15 5 for for IN cord-000580-dcid9emx 15 6 the the DT cord-000580-dcid9emx 15 7 ability ability NN cord-000580-dcid9emx 15 8 of of IN cord-000580-dcid9emx 15 9 all all DT cord-000580-dcid9emx 15 10 cellular cellular JJ cord-000580-dcid9emx 15 11 organisms organism NNS cord-000580-dcid9emx 15 12 to to TO cord-000580-dcid9emx 15 13 respond respond VB cord-000580-dcid9emx 15 14 and and CC cord-000580-dcid9emx 15 15 interact interact VB cord-000580-dcid9emx 15 16 with with IN cord-000580-dcid9emx 15 17 their -PRON- PRP$ cord-000580-dcid9emx 15 18 environment environment NN cord-000580-dcid9emx 15 19 . . . cord-000580-dcid9emx 16 1 Therefore therefore RB cord-000580-dcid9emx 16 2 they -PRON- PRP cord-000580-dcid9emx 16 3 have have VBP cord-000580-dcid9emx 16 4 attained attain VBN cord-000580-dcid9emx 16 5 large large JJ cord-000580-dcid9emx 16 6 research research NN cord-000580-dcid9emx 16 7 interest interest NN cord-000580-dcid9emx 16 8 and and CC cord-000580-dcid9emx 16 9 are be VBP cord-000580-dcid9emx 16 10 one one CD cord-000580-dcid9emx 16 11 of of IN cord-000580-dcid9emx 16 12 the the DT cord-000580-dcid9emx 16 13 major major JJ cord-000580-dcid9emx 16 14 groups group NNS cord-000580-dcid9emx 16 15 of of IN cord-000580-dcid9emx 16 16 drug drug NN cord-000580-dcid9emx 16 17 targets target NNS cord-000580-dcid9emx 16 18 [ [ -LRB- cord-000580-dcid9emx 16 19 1 1 CD cord-000580-dcid9emx 16 20 ] ] -RRB- cord-000580-dcid9emx 16 21 . . . cord-000580-dcid9emx 17 1 We -PRON- PRP cord-000580-dcid9emx 17 2 have have VBP cord-000580-dcid9emx 17 3 previously previously RB cord-000580-dcid9emx 17 4 estimated estimate VBN cord-000580-dcid9emx 17 5 that that IN cord-000580-dcid9emx 17 6 27 27 CD cord-000580-dcid9emx 17 7 % % NN cord-000580-dcid9emx 17 8 of of IN cord-000580-dcid9emx 17 9 the the DT cord-000580-dcid9emx 17 10 human human JJ cord-000580-dcid9emx 17 11 genes gene NNS cord-000580-dcid9emx 17 12 codes code NNS cord-000580-dcid9emx 17 13 for for IN cord-000580-dcid9emx 17 14 alpha alpha NN cord-000580-dcid9emx 17 15 - - HYPH cord-000580-dcid9emx 17 16 helical helical JJ cord-000580-dcid9emx 17 17 membrane membrane NN cord-000580-dcid9emx 17 18 proteins protein NNS cord-000580-dcid9emx 17 19 and and CC cord-000580-dcid9emx 17 20 provided provide VBD cord-000580-dcid9emx 17 21 a a DT cord-000580-dcid9emx 17 22 comprehensive comprehensive JJ cord-000580-dcid9emx 17 23 classification classification NN cord-000580-dcid9emx 17 24 based base VBN cord-000580-dcid9emx 17 25 on on IN cord-000580-dcid9emx 17 26 their -PRON- PRP$ cord-000580-dcid9emx 17 27 function function NN cord-000580-dcid9emx 17 28 and and CC cord-000580-dcid9emx 17 29 evolutionary evolutionary JJ cord-000580-dcid9emx 17 30 origin origin NN cord-000580-dcid9emx 17 31 [ [ -LRB- cord-000580-dcid9emx 17 32 2 2 CD cord-000580-dcid9emx 17 33 ] ] -RRB- cord-000580-dcid9emx 17 34 . . . cord-000580-dcid9emx 18 1 However however RB cord-000580-dcid9emx 18 2 , , , cord-000580-dcid9emx 18 3 the the DT cord-000580-dcid9emx 18 4 identification identification NN cord-000580-dcid9emx 18 5 and and CC cord-000580-dcid9emx 18 6 annotation annotation NN cord-000580-dcid9emx 18 7 of of IN cord-000580-dcid9emx 18 8 many many JJ cord-000580-dcid9emx 18 9 membrane membrane NN cord-000580-dcid9emx 18 10 bound bind VBD cord-000580-dcid9emx 18 11 protein protein NN cord-000580-dcid9emx 18 12 families family NNS cord-000580-dcid9emx 18 13 is be VBZ cord-000580-dcid9emx 18 14 still still RB cord-000580-dcid9emx 18 15 being be VBG cord-000580-dcid9emx 18 16 revised revise VBN cord-000580-dcid9emx 18 17 . . . cord-000580-dcid9emx 19 1 We -PRON- PRP cord-000580-dcid9emx 19 2 have have VBP cord-000580-dcid9emx 19 3 during during IN cord-000580-dcid9emx 19 4 recent recent JJ cord-000580-dcid9emx 19 5 years year NNS cord-000580-dcid9emx 19 6 worked work VBD cord-000580-dcid9emx 19 7 on on IN cord-000580-dcid9emx 19 8 the the DT cord-000580-dcid9emx 19 9 annotation annotation NN cord-000580-dcid9emx 19 10 of of IN cord-000580-dcid9emx 19 11 both both CC cord-000580-dcid9emx 19 12 G g NN cord-000580-dcid9emx 19 13 protein protein NN cord-000580-dcid9emx 19 14 - - HYPH cord-000580-dcid9emx 19 15 coupled couple VBN cord-000580-dcid9emx 19 16 receptors receptor NNS cord-000580-dcid9emx 19 17 [ [ -LRB- cord-000580-dcid9emx 19 18 3 3 CD cord-000580-dcid9emx 19 19 , , , cord-000580-dcid9emx 19 20 4 4 CD cord-000580-dcid9emx 19 21 ] ] -RRB- cord-000580-dcid9emx 19 22 and and CC cord-000580-dcid9emx 19 23 solute solute NN cord-000580-dcid9emx 19 24 carriers carrier NNS cord-000580-dcid9emx 19 25 [ [ -LRB- cord-000580-dcid9emx 19 26 5 5 CD cord-000580-dcid9emx 19 27 ] ] -RRB- cord-000580-dcid9emx 19 28 and and CC cord-000580-dcid9emx 19 29 most most JJS cord-000580-dcid9emx 19 30 of of IN cord-000580-dcid9emx 19 31 the the DT cord-000580-dcid9emx 19 32 genes gene NNS cord-000580-dcid9emx 19 33 of of IN cord-000580-dcid9emx 19 34 these these DT cord-000580-dcid9emx 19 35 large large JJ cord-000580-dcid9emx 19 36 superfamilies superfamily NNS cord-000580-dcid9emx 19 37 now now RB cord-000580-dcid9emx 19 38 have have VBP cord-000580-dcid9emx 19 39 a a DT cord-000580-dcid9emx 19 40 clear clear JJ cord-000580-dcid9emx 19 41 identity identity NN cord-000580-dcid9emx 19 42 and and CC cord-000580-dcid9emx 19 43 annotation annotation NN cord-000580-dcid9emx 19 44 . . . cord-000580-dcid9emx 20 1 There there EX cord-000580-dcid9emx 20 2 is be VBZ cord-000580-dcid9emx 20 3 however however RB cord-000580-dcid9emx 20 4 still still RB cord-000580-dcid9emx 20 5 large large JJ cord-000580-dcid9emx 20 6 work work NN cord-000580-dcid9emx 20 7 to to TO cord-000580-dcid9emx 20 8 be be VB cord-000580-dcid9emx 20 9 done do VBN cord-000580-dcid9emx 20 10 to to TO cord-000580-dcid9emx 20 11 clarify clarify VB cord-000580-dcid9emx 20 12 the the DT cord-000580-dcid9emx 20 13 identity identity NN cord-000580-dcid9emx 20 14 , , , cord-000580-dcid9emx 20 15 annotation annotation NN cord-000580-dcid9emx 20 16 and and CC cord-000580-dcid9emx 20 17 the the DT cord-000580-dcid9emx 20 18 evolutionary evolutionary JJ cord-000580-dcid9emx 20 19 history history NN cord-000580-dcid9emx 20 20 of of IN cord-000580-dcid9emx 20 21 several several JJ cord-000580-dcid9emx 20 22 families family NNS cord-000580-dcid9emx 20 23 of of IN cord-000580-dcid9emx 20 24 membrane membrane NN cord-000580-dcid9emx 20 25 bound bind VBN cord-000580-dcid9emx 20 26 proteins protein NNS cord-000580-dcid9emx 20 27 . . . cord-000580-dcid9emx 21 1 Establishing establish VBG cord-000580-dcid9emx 21 2 a a DT cord-000580-dcid9emx 21 3 rigid rigid JJ cord-000580-dcid9emx 21 4 nomenclature nomenclature NN cord-000580-dcid9emx 21 5 based base VBN cord-000580-dcid9emx 21 6 on on IN cord-000580-dcid9emx 21 7 evolutionary evolutionary JJ cord-000580-dcid9emx 21 8 information information NN cord-000580-dcid9emx 21 9 and and CC cord-000580-dcid9emx 21 10 structural structural JJ cord-000580-dcid9emx 21 11 features feature NNS cord-000580-dcid9emx 21 12 of of IN cord-000580-dcid9emx 21 13 the the DT cord-000580-dcid9emx 21 14 predicted predict VBN cord-000580-dcid9emx 21 15 proteins protein NNS cord-000580-dcid9emx 21 16 facilitates facilitate VBZ cord-000580-dcid9emx 21 17 prediction prediction NN cord-000580-dcid9emx 21 18 of of IN cord-000580-dcid9emx 21 19 the the DT cord-000580-dcid9emx 21 20 functional functional JJ cord-000580-dcid9emx 21 21 role role NN cord-000580-dcid9emx 21 22 of of IN cord-000580-dcid9emx 21 23 these these DT cord-000580-dcid9emx 21 24 genes gene NNS cord-000580-dcid9emx 21 25 that that WDT cord-000580-dcid9emx 21 26 often often RB cord-000580-dcid9emx 21 27 have have VBP cord-000580-dcid9emx 21 28 only only RB cord-000580-dcid9emx 21 29 have have VBP cord-000580-dcid9emx 21 30 been be VBN cord-000580-dcid9emx 21 31 studied study VBN cord-000580-dcid9emx 21 32 in in IN cord-000580-dcid9emx 21 33 large large JJ cord-000580-dcid9emx 21 34 gene gene NN cord-000580-dcid9emx 21 35 or or CC cord-000580-dcid9emx 21 36 transcription transcription NN cord-000580-dcid9emx 21 37 consortia consortium NNS cord-000580-dcid9emx 21 38 . . . cord-000580-dcid9emx 22 1 In in IN cord-000580-dcid9emx 22 2 previous previous JJ cord-000580-dcid9emx 22 3 studies study NNS cord-000580-dcid9emx 22 4 we -PRON- PRP cord-000580-dcid9emx 22 5 have have VBP cord-000580-dcid9emx 22 6 found find VBN cord-000580-dcid9emx 22 7 that that IN cord-000580-dcid9emx 22 8 membrane membrane NN cord-000580-dcid9emx 22 9 proteins protein NNS cord-000580-dcid9emx 22 10 with with IN cord-000580-dcid9emx 22 11 few few JJ cord-000580-dcid9emx 22 12 transmembrane transmembrane NN cord-000580-dcid9emx 22 13 ( ( -LRB- cord-000580-dcid9emx 22 14 TM TM NNP cord-000580-dcid9emx 22 15 ) ) -RRB- cord-000580-dcid9emx 22 16 helices helix NNS cord-000580-dcid9emx 22 17 are be VBP cord-000580-dcid9emx 22 18 less less RBR cord-000580-dcid9emx 22 19 studied study VBN cord-000580-dcid9emx 22 20 than than IN cord-000580-dcid9emx 22 21 other other JJ cord-000580-dcid9emx 22 22 . . . cord-000580-dcid9emx 23 1 This this DT cord-000580-dcid9emx 23 2 is be VBZ cord-000580-dcid9emx 23 3 particularly particularly RB cord-000580-dcid9emx 23 4 true true JJ cord-000580-dcid9emx 23 5 for for IN cord-000580-dcid9emx 23 6 2TM 2tm NN cord-000580-dcid9emx 23 7 proteins protein NNS cord-000580-dcid9emx 23 8 where where WRB cord-000580-dcid9emx 23 9 more more JJR cord-000580-dcid9emx 23 10 than than IN cord-000580-dcid9emx 23 11 70 70 CD cord-000580-dcid9emx 23 12 % % NN cord-000580-dcid9emx 23 13 of of IN cord-000580-dcid9emx 23 14 the the DT cord-000580-dcid9emx 23 15 about about RB cord-000580-dcid9emx 23 16 700 700 CD cord-000580-dcid9emx 23 17 proteins protein NNS cord-000580-dcid9emx 23 18 remained remain VBD cord-000580-dcid9emx 23 19 unclassified unclassified JJ cord-000580-dcid9emx 23 20 . . . cord-000580-dcid9emx 24 1 Interestingly interestingly RB cord-000580-dcid9emx 24 2 , , , cord-000580-dcid9emx 24 3 we -PRON- PRP cord-000580-dcid9emx 24 4 found find VBD cord-000580-dcid9emx 24 5 evidence evidence NN cord-000580-dcid9emx 24 6 for for IN cord-000580-dcid9emx 24 7 several several JJ cord-000580-dcid9emx 24 8 uncharacterized uncharacterized JJ cord-000580-dcid9emx 24 9 homologues homologue NNS cord-000580-dcid9emx 24 10 to to IN cord-000580-dcid9emx 24 11 a a DT cord-000580-dcid9emx 24 12 small small JJ cord-000580-dcid9emx 24 13 group group NN cord-000580-dcid9emx 24 14 of of IN cord-000580-dcid9emx 24 15 genes gene NNS cord-000580-dcid9emx 24 16 known know VBN cord-000580-dcid9emx 24 17 as as IN cord-000580-dcid9emx 24 18 the the DT cord-000580-dcid9emx 24 19 Interferon Interferon NNP cord-000580-dcid9emx 24 20 - - HYPH cord-000580-dcid9emx 24 21 induced induce VBN cord-000580-dcid9emx 24 22 transmembrane transmembrane NN cord-000580-dcid9emx 24 23 proteins protein NNS cord-000580-dcid9emx 24 24 ( ( -LRB- cord-000580-dcid9emx 24 25 IFITM IFITM NNP cord-000580-dcid9emx 24 26 ) ) -RRB- cord-000580-dcid9emx 24 27 family family NN cord-000580-dcid9emx 24 28 . . . cord-000580-dcid9emx 25 1 The the DT cord-000580-dcid9emx 25 2 IFITMs ifitm NNS cord-000580-dcid9emx 25 3 constitute constitute VBP cord-000580-dcid9emx 25 4 a a DT cord-000580-dcid9emx 25 5 group group NN cord-000580-dcid9emx 25 6 with with IN cord-000580-dcid9emx 25 7 four four CD cord-000580-dcid9emx 25 8 human human JJ cord-000580-dcid9emx 25 9 members member NNS cord-000580-dcid9emx 25 10 ( ( -LRB- cord-000580-dcid9emx 25 11 IFITM1 IFITM1 NNP cord-000580-dcid9emx 25 12 - - HYPH cord-000580-dcid9emx 25 13 3 3 CD cord-000580-dcid9emx 25 14 , , , cord-000580-dcid9emx 25 15 5 5 CD cord-000580-dcid9emx 25 16 ) ) -RRB- cord-000580-dcid9emx 25 17 that that WDT cord-000580-dcid9emx 25 18 are be VBP cord-000580-dcid9emx 25 19 found find VBN cord-000580-dcid9emx 25 20 in in IN cord-000580-dcid9emx 25 21 a a DT cord-000580-dcid9emx 25 22 consecutive consecutive JJ cord-000580-dcid9emx 25 23 order order NN cord-000580-dcid9emx 25 24 on on IN cord-000580-dcid9emx 25 25 chromosome chromosome NN cord-000580-dcid9emx 25 26 11 11 CD cord-000580-dcid9emx 25 27 , , , cord-000580-dcid9emx 25 28 having have VBG cord-000580-dcid9emx 25 29 two two CD cord-000580-dcid9emx 25 30 transmembrane transmembrane NN cord-000580-dcid9emx 25 31 ( ( -LRB- cord-000580-dcid9emx 25 32 2TM 2tm NN cord-000580-dcid9emx 25 33 ) ) -RRB- cord-000580-dcid9emx 25 34 helices helix NNS cord-000580-dcid9emx 25 35 . . . cord-000580-dcid9emx 26 1 The the DT cord-000580-dcid9emx 26 2 IFITM4 ifitm4 NN cord-000580-dcid9emx 26 3 gene gene NN cord-000580-dcid9emx 26 4 is be VBZ cord-000580-dcid9emx 26 5 not not RB cord-000580-dcid9emx 26 6 present present JJ cord-000580-dcid9emx 26 7 in in IN cord-000580-dcid9emx 26 8 human human NN cord-000580-dcid9emx 26 9 , , , cord-000580-dcid9emx 26 10 but but CC cord-000580-dcid9emx 26 11 is be VBZ cord-000580-dcid9emx 26 12 located locate VBN cord-000580-dcid9emx 26 13 in in IN cord-000580-dcid9emx 26 14 proximity proximity NN cord-000580-dcid9emx 26 15 to to IN cord-000580-dcid9emx 26 16 the the DT cord-000580-dcid9emx 26 17 other other JJ cord-000580-dcid9emx 26 18 four four CD cord-000580-dcid9emx 26 19 genes gene NNS cord-000580-dcid9emx 26 20 in in IN cord-000580-dcid9emx 26 21 the the DT cord-000580-dcid9emx 26 22 mouse mouse NN cord-000580-dcid9emx 26 23 genome genome NN cord-000580-dcid9emx 26 24 . . . cord-000580-dcid9emx 27 1 The the DT cord-000580-dcid9emx 27 2 IFITM1 ifitm1 NN cord-000580-dcid9emx 27 3 - - HYPH cord-000580-dcid9emx 27 4 3 3 CD cord-000580-dcid9emx 27 5 proteins protein NNS cord-000580-dcid9emx 27 6 were be VBD cord-000580-dcid9emx 27 7 identified identify VBN cord-000580-dcid9emx 27 8 25 25 CD cord-000580-dcid9emx 27 9 years year NNS cord-000580-dcid9emx 27 10 ago ago RB cord-000580-dcid9emx 27 11 as as IN cord-000580-dcid9emx 27 12 being be VBG cord-000580-dcid9emx 27 13 upregulated upregulate VBN cord-000580-dcid9emx 27 14 by by IN cord-000580-dcid9emx 27 15 interferons interferon NNS cord-000580-dcid9emx 27 16 ( ( -LRB- cord-000580-dcid9emx 27 17 IFN IFN NNP cord-000580-dcid9emx 27 18 ) ) -RRB- cord-000580-dcid9emx 27 19 [ [ -LRB- cord-000580-dcid9emx 27 20 6 6 CD cord-000580-dcid9emx 27 21 ] ] -RRB- cord-000580-dcid9emx 27 22 . . . cord-000580-dcid9emx 28 1 Recently recently RB cord-000580-dcid9emx 28 2 they -PRON- PRP cord-000580-dcid9emx 28 3 received receive VBD cord-000580-dcid9emx 28 4 considerable considerable JJ cord-000580-dcid9emx 28 5 attentions attention NNS cord-000580-dcid9emx 28 6 as as IN cord-000580-dcid9emx 28 7 IFITM1 ifitm1 NN cord-000580-dcid9emx 28 8 - - HYPH cord-000580-dcid9emx 28 9 3 3 CD cord-000580-dcid9emx 28 10 were be VBD cord-000580-dcid9emx 28 11 found find VBN cord-000580-dcid9emx 28 12 to to TO cord-000580-dcid9emx 28 13 prevent prevent VB cord-000580-dcid9emx 28 14 infection infection NN cord-000580-dcid9emx 28 15 of of IN cord-000580-dcid9emx 28 16 a a DT cord-000580-dcid9emx 28 17 growing grow VBG cord-000580-dcid9emx 28 18 list list NN cord-000580-dcid9emx 28 19 of of IN cord-000580-dcid9emx 28 20 viruses virus NNS cord-000580-dcid9emx 28 21 such such JJ cord-000580-dcid9emx 28 22 as as IN cord-000580-dcid9emx 28 23 HIV-1 HIV-1 NNP cord-000580-dcid9emx 28 24 , , , cord-000580-dcid9emx 28 25 SARS SARS NNP cord-000580-dcid9emx 28 26 influenza influenza NN cord-000580-dcid9emx 28 27 A a DT cord-000580-dcid9emx 28 28 H1N1 H1N1 NNP cord-000580-dcid9emx 28 29 , , , cord-000580-dcid9emx 28 30 West West NNP cord-000580-dcid9emx 28 31 Nile Nile NNP cord-000580-dcid9emx 28 32 and and CC cord-000580-dcid9emx 28 33 Dengue Dengue NNP cord-000580-dcid9emx 28 34 fever fever NN cord-000580-dcid9emx 28 35 viruses virus NNS cord-000580-dcid9emx 28 36 [ [ -LRB- cord-000580-dcid9emx 28 37 7 7 CD cord-000580-dcid9emx 28 38 , , , cord-000580-dcid9emx 28 39 8 8 CD cord-000580-dcid9emx 28 40 , , , cord-000580-dcid9emx 28 41 9 9 CD cord-000580-dcid9emx 28 42 , , , cord-000580-dcid9emx 28 43 10 10 CD cord-000580-dcid9emx 28 44 ] ] -RRB- cord-000580-dcid9emx 28 45 . . . cord-000580-dcid9emx 29 1 Hence hence RB cord-000580-dcid9emx 29 2 , , , cord-000580-dcid9emx 29 3 proteins protein NNS cord-000580-dcid9emx 29 4 of of IN cord-000580-dcid9emx 29 5 the the DT cord-000580-dcid9emx 29 6 IFITM IFITM NNP cord-000580-dcid9emx 29 7 family family NN cord-000580-dcid9emx 29 8 mediate mediate VBP cord-000580-dcid9emx 29 9 part part NN cord-000580-dcid9emx 29 10 of of IN cord-000580-dcid9emx 29 11 the the DT cord-000580-dcid9emx 29 12 antiviral antiviral JJ cord-000580-dcid9emx 29 13 response response NN cord-000580-dcid9emx 29 14 orchestrated orchestrate VBN cord-000580-dcid9emx 29 15 by by IN cord-000580-dcid9emx 29 16 IFNs ifn NNS cord-000580-dcid9emx 29 17 . . . cord-000580-dcid9emx 30 1 However however RB cord-000580-dcid9emx 30 2 , , , cord-000580-dcid9emx 30 3 the the DT cord-000580-dcid9emx 30 4 IFITM IFITM NNP cord-000580-dcid9emx 30 5 family family NN cord-000580-dcid9emx 30 6 is be VBZ cord-000580-dcid9emx 30 7 also also RB cord-000580-dcid9emx 30 8 involved involve VBN cord-000580-dcid9emx 30 9 in in IN cord-000580-dcid9emx 30 10 other other JJ cord-000580-dcid9emx 30 11 processes process NNS cord-000580-dcid9emx 30 12 such such JJ cord-000580-dcid9emx 30 13 as as IN cord-000580-dcid9emx 30 14 oncogenesis oncogenesis NN cord-000580-dcid9emx 30 15 , , , cord-000580-dcid9emx 30 16 bone bone NN cord-000580-dcid9emx 30 17 mineralization mineralization NN cord-000580-dcid9emx 30 18 ( ( -LRB- cord-000580-dcid9emx 30 19 IFITM5 IFITM5 NNP cord-000580-dcid9emx 30 20 ) ) -RRB- cord-000580-dcid9emx 30 21 and and CC cord-000580-dcid9emx 30 22 germ germ NN cord-000580-dcid9emx 30 23 cell cell NN cord-000580-dcid9emx 30 24 development development NN cord-000580-dcid9emx 30 25 ( ( -LRB- cord-000580-dcid9emx 30 26 IFITM1 ifitm1 NN cord-000580-dcid9emx 30 27 and and CC cord-000580-dcid9emx 30 28 3 3 CD cord-000580-dcid9emx 30 29 ) ) -RRB- cord-000580-dcid9emx 30 30 and and CC cord-000580-dcid9emx 31 1 IFITM5 IFITM5 NNP cord-000580-dcid9emx 31 2 has have VBZ cord-000580-dcid9emx 31 3 not not RB cord-000580-dcid9emx 31 4 been be VBN cord-000580-dcid9emx 31 5 identified identify VBN cord-000580-dcid9emx 31 6 as as IN cord-000580-dcid9emx 31 7 interferon interferon NN cord-000580-dcid9emx 31 8 - - HYPH cord-000580-dcid9emx 31 9 inducible inducible JJ cord-000580-dcid9emx 31 10 [ [ -LRB- cord-000580-dcid9emx 31 11 11 11 CD cord-000580-dcid9emx 31 12 , , , cord-000580-dcid9emx 31 13 12 12 CD cord-000580-dcid9emx 31 14 , , , cord-000580-dcid9emx 31 15 13 13 CD cord-000580-dcid9emx 31 16 , , , cord-000580-dcid9emx 31 17 14 14 CD cord-000580-dcid9emx 31 18 ] ] -RRB- cord-000580-dcid9emx 31 19 . . . cord-000580-dcid9emx 32 1 Although although IN cord-000580-dcid9emx 32 2 the the DT cord-000580-dcid9emx 32 3 biological biological JJ cord-000580-dcid9emx 32 4 roles role NNS cord-000580-dcid9emx 32 5 of of IN cord-000580-dcid9emx 32 6 the the DT cord-000580-dcid9emx 32 7 IFITM IFITM NNP cord-000580-dcid9emx 32 8 genes gene NNS cord-000580-dcid9emx 32 9 are be VBP cord-000580-dcid9emx 32 10 emerging emerge VBG cord-000580-dcid9emx 32 11 , , , cord-000580-dcid9emx 32 12 no no DT cord-000580-dcid9emx 32 13 thorough thorough JJ cord-000580-dcid9emx 32 14 evolutionary evolutionary JJ cord-000580-dcid9emx 32 15 analysis analysis NN cord-000580-dcid9emx 32 16 has have VBZ cord-000580-dcid9emx 32 17 been be VBN cord-000580-dcid9emx 32 18 performed perform VBN cord-000580-dcid9emx 32 19 on on IN cord-000580-dcid9emx 32 20 this this DT cord-000580-dcid9emx 32 21 group group NN cord-000580-dcid9emx 32 22 . . . cord-000580-dcid9emx 33 1 In in IN cord-000580-dcid9emx 33 2 this this DT cord-000580-dcid9emx 33 3 study study NN cord-000580-dcid9emx 33 4 , , , cord-000580-dcid9emx 33 5 we -PRON- PRP cord-000580-dcid9emx 33 6 sought seek VBD cord-000580-dcid9emx 33 7 to to TO cord-000580-dcid9emx 33 8 infer infer VB cord-000580-dcid9emx 33 9 the the DT cord-000580-dcid9emx 33 10 evolutionary evolutionary JJ cord-000580-dcid9emx 33 11 history history NN cord-000580-dcid9emx 33 12 of of IN cord-000580-dcid9emx 33 13 the the DT cord-000580-dcid9emx 33 14 human human JJ cord-000580-dcid9emx 33 15 IFITM IFITM NNP cord-000580-dcid9emx 33 16 genes gene NNS cord-000580-dcid9emx 33 17 and and CC cord-000580-dcid9emx 33 18 identify identify VB cord-000580-dcid9emx 33 19 potential potential JJ cord-000580-dcid9emx 33 20 homologues homologue NNS cord-000580-dcid9emx 33 21 . . . cord-000580-dcid9emx 34 1 We -PRON- PRP cord-000580-dcid9emx 34 2 mined mine VBD cord-000580-dcid9emx 34 3 36 36 CD cord-000580-dcid9emx 34 4 eukaryotic eukaryotic JJ cord-000580-dcid9emx 34 5 species specie NNS cord-000580-dcid9emx 34 6 , , , cord-000580-dcid9emx 34 7 covering cover VBG cord-000580-dcid9emx 34 8 all all DT cord-000580-dcid9emx 34 9 major major JJ cord-000580-dcid9emx 34 10 eukaryotic eukaryotic JJ cord-000580-dcid9emx 34 11 groups group NNS cord-000580-dcid9emx 34 12 , , , cord-000580-dcid9emx 34 13 and and CC cord-000580-dcid9emx 34 14 found find VBD cord-000580-dcid9emx 34 15 that that IN cord-000580-dcid9emx 34 16 the the DT cord-000580-dcid9emx 34 17 IFITMs IFITMs NNPS cord-000580-dcid9emx 34 18 form form VBP cord-000580-dcid9emx 34 19 a a DT cord-000580-dcid9emx 34 20 subfamily subfamily NN cord-000580-dcid9emx 34 21 in in IN cord-000580-dcid9emx 34 22 a a DT cord-000580-dcid9emx 34 23 larger large JJR cord-000580-dcid9emx 34 24 novel novel JJ cord-000580-dcid9emx 34 25 family family NN cord-000580-dcid9emx 34 26 that that WDT cord-000580-dcid9emx 34 27 has have VBZ cord-000580-dcid9emx 34 28 ten ten CD cord-000580-dcid9emx 34 29 human human JJ cord-000580-dcid9emx 34 30 members member NNS cord-000580-dcid9emx 34 31 in in IN cord-000580-dcid9emx 34 32 addition addition NN cord-000580-dcid9emx 34 33 to to IN cord-000580-dcid9emx 34 34 the the DT cord-000580-dcid9emx 34 35 four four CD cord-000580-dcid9emx 34 36 IFITM IFITM NNP cord-000580-dcid9emx 34 37 genes gene NNS cord-000580-dcid9emx 34 38 . . . cord-000580-dcid9emx 35 1 We -PRON- PRP cord-000580-dcid9emx 35 2 propose propose VBP cord-000580-dcid9emx 35 3 Dispanins Dispanins NNPS cord-000580-dcid9emx 35 4 as as IN cord-000580-dcid9emx 35 5 a a DT cord-000580-dcid9emx 35 6 novel novel JJ cord-000580-dcid9emx 35 7 name name NN cord-000580-dcid9emx 35 8 for for IN cord-000580-dcid9emx 35 9 this this DT cord-000580-dcid9emx 35 10 family family NN cord-000580-dcid9emx 35 11 , , , cord-000580-dcid9emx 35 12 which which WDT cord-000580-dcid9emx 35 13 refers refer VBZ cord-000580-dcid9emx 35 14 to to IN cord-000580-dcid9emx 35 15 their -PRON- PRP$ cord-000580-dcid9emx 35 16 common common JJ cord-000580-dcid9emx 35 17 2TM 2tm CD cord-000580-dcid9emx 35 18 structure structure NN cord-000580-dcid9emx 35 19 . . . cord-000580-dcid9emx 36 1 Further further RB cord-000580-dcid9emx 36 2 , , , cord-000580-dcid9emx 36 3 we -PRON- PRP cord-000580-dcid9emx 36 4 find find VBP cord-000580-dcid9emx 36 5 that that IN cord-000580-dcid9emx 36 6 the the DT cord-000580-dcid9emx 36 7 eukaryotic eukaryotic JJ cord-000580-dcid9emx 36 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 36 9 first first RB cord-000580-dcid9emx 36 10 appeared appear VBD cord-000580-dcid9emx 36 11 before before IN cord-000580-dcid9emx 36 12 the the DT cord-000580-dcid9emx 36 13 radiation radiation NN cord-000580-dcid9emx 36 14 of of IN cord-000580-dcid9emx 36 15 metazoa metazoa NNP cord-000580-dcid9emx 36 16 and and CC cord-000580-dcid9emx 36 17 that that IN cord-000580-dcid9emx 36 18 they -PRON- PRP cord-000580-dcid9emx 36 19 branch branch VBP cord-000580-dcid9emx 36 20 out out RP cord-000580-dcid9emx 36 21 into into IN cord-000580-dcid9emx 36 22 four four CD cord-000580-dcid9emx 36 23 subfamilies subfamily NNS cord-000580-dcid9emx 36 24 ( ( -LRB- cord-000580-dcid9emx 36 25 A A NNP cord-000580-dcid9emx 36 26 - - HYPH cord-000580-dcid9emx 36 27 D D NNP cord-000580-dcid9emx 36 28 ) ) -RRB- cord-000580-dcid9emx 36 29 . . . cord-000580-dcid9emx 37 1 More more RBR cord-000580-dcid9emx 37 2 surprisingly surprisingly RB cord-000580-dcid9emx 37 3 , , , cord-000580-dcid9emx 37 4 we -PRON- PRP cord-000580-dcid9emx 37 5 also also RB cord-000580-dcid9emx 37 6 discover discover VBP cord-000580-dcid9emx 37 7 that that IN cord-000580-dcid9emx 37 8 the the DT cord-000580-dcid9emx 37 9 Dispanins Dispanins NNPS cord-000580-dcid9emx 37 10 are be VBP cord-000580-dcid9emx 37 11 found find VBN cord-000580-dcid9emx 37 12 in in IN cord-000580-dcid9emx 37 13 a a DT cord-000580-dcid9emx 37 14 large large JJ cord-000580-dcid9emx 37 15 range range NN cord-000580-dcid9emx 37 16 of of IN cord-000580-dcid9emx 37 17 bacteria bacteria NNS cord-000580-dcid9emx 37 18 and and CC cord-000580-dcid9emx 37 19 in in IN cord-000580-dcid9emx 37 20 brown brown JJ cord-000580-dcid9emx 37 21 alga alga NN cord-000580-dcid9emx 37 22 . . . cord-000580-dcid9emx 38 1 In in IN cord-000580-dcid9emx 38 2 total total NN cord-000580-dcid9emx 38 3 , , , cord-000580-dcid9emx 38 4 we -PRON- PRP cord-000580-dcid9emx 38 5 collected collect VBD cord-000580-dcid9emx 38 6 87 87 CD cord-000580-dcid9emx 38 7 eukaryotic eukaryotic JJ cord-000580-dcid9emx 38 8 IFITM IFITM NNP cord-000580-dcid9emx 38 9 homologues homologue NNS cord-000580-dcid9emx 38 10 from from IN cord-000580-dcid9emx 38 11 H. H. NNP cord-000580-dcid9emx 38 12 Sapiens Sapiens NNP cord-000580-dcid9emx 38 13 ( ( -LRB- cord-000580-dcid9emx 38 14 14 14 CD cord-000580-dcid9emx 38 15 genes gene NNS cord-000580-dcid9emx 38 16 ) ) -RRB- cord-000580-dcid9emx 39 1 M. M. NNP cord-000580-dcid9emx 39 2 musculus musculus NN cord-000580-dcid9emx 39 3 ( ( -LRB- cord-000580-dcid9emx 39 4 17 17 CD cord-000580-dcid9emx 39 5 genes gene NNS cord-000580-dcid9emx 39 6 ) ) -RRB- cord-000580-dcid9emx 39 7 , , , cord-000580-dcid9emx 39 8 G. G. NNP cord-000580-dcid9emx 39 9 gallus gallus NN cord-000580-dcid9emx 39 10 ( ( -LRB- cord-000580-dcid9emx 39 11 6 6 CD cord-000580-dcid9emx 39 12 genes gene NNS cord-000580-dcid9emx 39 13 ) ) -RRB- cord-000580-dcid9emx 39 14 , , , cord-000580-dcid9emx 39 15 X. X. NNP cord-000580-dcid9emx 39 16 tropicalis tropicalis NNP cord-000580-dcid9emx 39 17 ( ( -LRB- cord-000580-dcid9emx 39 18 13 13 CD cord-000580-dcid9emx 39 19 genes gene NNS cord-000580-dcid9emx 39 20 ) ) -RRB- cord-000580-dcid9emx 39 21 , , , cord-000580-dcid9emx 39 22 D. D. NNP cord-000580-dcid9emx 39 23 rerio rerio NNP cord-000580-dcid9emx 39 24 ( ( -LRB- cord-000580-dcid9emx 39 25 7 7 CD cord-000580-dcid9emx 39 26 genes gene NNS cord-000580-dcid9emx 39 27 ) ) -RRB- cord-000580-dcid9emx 39 28 , , , cord-000580-dcid9emx 39 29 P. P. NNP cord-000580-dcid9emx 39 30 marinus marinus NNP cord-000580-dcid9emx 39 31 ( ( -LRB- cord-000580-dcid9emx 39 32 1 1 CD cord-000580-dcid9emx 39 33 gene gene NN cord-000580-dcid9emx 39 34 ) ) -RRB- cord-000580-dcid9emx 39 35 , , , cord-000580-dcid9emx 39 36 C. C. NNP cord-000580-dcid9emx 39 37 intestinalis intestinalis NNP cord-000580-dcid9emx 39 38 ( ( -LRB- cord-000580-dcid9emx 39 39 1 1 CD cord-000580-dcid9emx 39 40 gene gene NN cord-000580-dcid9emx 39 41 ) ) -RRB- cord-000580-dcid9emx 39 42 , , , cord-000580-dcid9emx 39 43 B.floridae B.floridae NNP cord-000580-dcid9emx 39 44 ( ( -LRB- cord-000580-dcid9emx 39 45 12 12 CD cord-000580-dcid9emx 39 46 genes gene NNS cord-000580-dcid9emx 39 47 ) ) -RRB- cord-000580-dcid9emx 39 48 , , , cord-000580-dcid9emx 39 49 S. S. NNP cord-000580-dcid9emx 39 50 manosoni manosoni NNP cord-000580-dcid9emx 39 51 ( ( -LRB- cord-000580-dcid9emx 39 52 1 1 CD cord-000580-dcid9emx 39 53 gene gene NN cord-000580-dcid9emx 39 54 ) ) -RRB- cord-000580-dcid9emx 39 55 , , , cord-000580-dcid9emx 39 56 S. S. NNP cord-000580-dcid9emx 39 57 purpuratus purpuratus NN cord-000580-dcid9emx 39 58 ( ( -LRB- cord-000580-dcid9emx 39 59 9 9 CD cord-000580-dcid9emx 39 60 genes gene NNS cord-000580-dcid9emx 39 61 ) ) -RRB- cord-000580-dcid9emx 39 62 , , , cord-000580-dcid9emx 39 63 N. N. NNP cord-000580-dcid9emx 39 64 vectensis vectensis NN cord-000580-dcid9emx 39 65 ( ( -LRB- cord-000580-dcid9emx 39 66 4 4 CD cord-000580-dcid9emx 39 67 genes gene NNS cord-000580-dcid9emx 39 68 ) ) -RRB- cord-000580-dcid9emx 39 69 and and CC cord-000580-dcid9emx 39 70 M. M. NNP cord-000580-dcid9emx 39 71 brevicollis brevicollis NNP cord-000580-dcid9emx 39 72 ( ( -LRB- cord-000580-dcid9emx 39 73 1 1 CD cord-000580-dcid9emx 39 74 gene gene NN cord-000580-dcid9emx 39 75 ) ) -RRB- cord-000580-dcid9emx 39 76 . . . cord-000580-dcid9emx 40 1 No no DT cord-000580-dcid9emx 40 2 IFITM IFITM NNP cord-000580-dcid9emx 40 3 genes gene NNS cord-000580-dcid9emx 40 4 could could MD cord-000580-dcid9emx 40 5 be be VB cord-000580-dcid9emx 40 6 detected detect VBN cord-000580-dcid9emx 40 7 in in IN cord-000580-dcid9emx 40 8 any any DT cord-000580-dcid9emx 40 9 of of IN cord-000580-dcid9emx 40 10 the the DT cord-000580-dcid9emx 40 11 remaining remain VBG cord-000580-dcid9emx 40 12 24 24 CD cord-000580-dcid9emx 40 13 analyzed analyze VBN cord-000580-dcid9emx 40 14 proteomes proteome NNS cord-000580-dcid9emx 40 15 , , , cord-000580-dcid9emx 40 16 which which WDT cord-000580-dcid9emx 40 17 covers cover VBZ cord-000580-dcid9emx 40 18 all all DT cord-000580-dcid9emx 40 19 other other JJ cord-000580-dcid9emx 40 20 major major JJ cord-000580-dcid9emx 40 21 eukaryotic eukaryotic JJ cord-000580-dcid9emx 40 22 groups group NNS cord-000580-dcid9emx 40 23 . . . cord-000580-dcid9emx 41 1 The the DT cord-000580-dcid9emx 41 2 search search NN cord-000580-dcid9emx 41 3 of of IN cord-000580-dcid9emx 41 4 the the DT cord-000580-dcid9emx 41 5 nr nr NN cord-000580-dcid9emx 41 6 database database NN cord-000580-dcid9emx 41 7 with with IN cord-000580-dcid9emx 41 8 HMMER HMMER NNP cord-000580-dcid9emx 41 9 did do VBD cord-000580-dcid9emx 41 10 not not RB cord-000580-dcid9emx 41 11 get get VB cord-000580-dcid9emx 41 12 any any DT cord-000580-dcid9emx 41 13 hits hit NNS cord-000580-dcid9emx 41 14 outside outside RB cord-000580-dcid9emx 41 15 metazoa metazoa RB cord-000580-dcid9emx 41 16 except except IN cord-000580-dcid9emx 41 17 bacteria bacteria NNS cord-000580-dcid9emx 41 18 , , , cord-000580-dcid9emx 41 19 choanoflagellates choanoflagellate NNS cord-000580-dcid9emx 41 20 and and CC cord-000580-dcid9emx 41 21 the the DT cord-000580-dcid9emx 41 22 brown brown JJ cord-000580-dcid9emx 41 23 alga alga NN cord-000580-dcid9emx 42 1 Ectocarpus Ectocarpus NNP cord-000580-dcid9emx 42 2 siliculosus siliculosus NNP cord-000580-dcid9emx 42 3 ( ( -LRB- cord-000580-dcid9emx 42 4 2 2 CD cord-000580-dcid9emx 42 5 genes gene NNS cord-000580-dcid9emx 42 6 ) ) -RRB- cord-000580-dcid9emx 42 7 . . . cord-000580-dcid9emx 43 1 Nine nine CD cord-000580-dcid9emx 43 2 genes gene NNS cord-000580-dcid9emx 43 3 were be VBD cord-000580-dcid9emx 43 4 deemed deem VBN cord-000580-dcid9emx 43 5 as as IN cord-000580-dcid9emx 43 6 pseudogenes pseudogene NNS cord-000580-dcid9emx 43 7 based base VBN cord-000580-dcid9emx 43 8 on on IN cord-000580-dcid9emx 43 9 annotation annotation NN cord-000580-dcid9emx 43 10 and and CC cord-000580-dcid9emx 43 11 sequence sequence NN cord-000580-dcid9emx 43 12 analysis analysis NN cord-000580-dcid9emx 43 13 and and CC cord-000580-dcid9emx 43 14 removed remove VBN cord-000580-dcid9emx 43 15 from from IN cord-000580-dcid9emx 43 16 further further JJ cord-000580-dcid9emx 43 17 analysis analysis NN cord-000580-dcid9emx 43 18 . . . cord-000580-dcid9emx 44 1 In in IN cord-000580-dcid9emx 44 2 addition addition NN cord-000580-dcid9emx 44 3 to to IN cord-000580-dcid9emx 44 4 the the DT cord-000580-dcid9emx 44 5 four four CD cord-000580-dcid9emx 44 6 previously previously RB cord-000580-dcid9emx 44 7 identified identify VBN cord-000580-dcid9emx 44 8 human human JJ cord-000580-dcid9emx 44 9 IFITM IFITM NNP cord-000580-dcid9emx 44 10 genes gene NNS cord-000580-dcid9emx 44 11 , , , cord-000580-dcid9emx 44 12 ten ten CD cord-000580-dcid9emx 44 13 novel novel JJ cord-000580-dcid9emx 44 14 human human JJ cord-000580-dcid9emx 44 15 homologous homologous JJ cord-000580-dcid9emx 44 16 genes gene NNS cord-000580-dcid9emx 44 17 were be VBD cord-000580-dcid9emx 44 18 detected detect VBN cord-000580-dcid9emx 44 19 . . . cord-000580-dcid9emx 45 1 These these DT cord-000580-dcid9emx 45 2 ten ten CD cord-000580-dcid9emx 45 3 genes gene NNS cord-000580-dcid9emx 45 4 together together RB cord-000580-dcid9emx 45 5 with with IN cord-000580-dcid9emx 45 6 the the DT cord-000580-dcid9emx 45 7 four four CD cord-000580-dcid9emx 45 8 IFITM IFITM NNP cord-000580-dcid9emx 45 9 genes gene NNS cord-000580-dcid9emx 45 10 form form VBP cord-000580-dcid9emx 45 11 a a DT cord-000580-dcid9emx 45 12 human human JJ cord-000580-dcid9emx 45 13 gene gene NN cord-000580-dcid9emx 45 14 family family NN cord-000580-dcid9emx 45 15 that that WDT cord-000580-dcid9emx 45 16 we -PRON- PRP cord-000580-dcid9emx 45 17 choose choose VBP cord-000580-dcid9emx 45 18 to to TO cord-000580-dcid9emx 45 19 call call VB cord-000580-dcid9emx 45 20 Dispanins Dispanins NNP cord-000580-dcid9emx 45 21 based base VBN cord-000580-dcid9emx 45 22 of of IN cord-000580-dcid9emx 45 23 their -PRON- PRP$ cord-000580-dcid9emx 45 24 common common JJ cord-000580-dcid9emx 45 25 2TM 2tm CD cord-000580-dcid9emx 45 26 structure structure NN cord-000580-dcid9emx 45 27 . . . cord-000580-dcid9emx 46 1 In in IN cord-000580-dcid9emx 46 2 UniProt UniProt NNP cord-000580-dcid9emx 46 3 we -PRON- PRP cord-000580-dcid9emx 46 4 identified identify VBD cord-000580-dcid9emx 46 5 65 65 CD cord-000580-dcid9emx 46 6 annotated annotate VBN cord-000580-dcid9emx 46 7 IFITM IFITM NNP cord-000580-dcid9emx 46 8 homologues homologue NNS cord-000580-dcid9emx 46 9 from from IN cord-000580-dcid9emx 46 10 full full JJ cord-000580-dcid9emx 46 11 bacteria bacteria NNS cord-000580-dcid9emx 46 12 proteome proteome NN cord-000580-dcid9emx 46 13 sets set NNS cord-000580-dcid9emx 46 14 spread spread VBD cord-000580-dcid9emx 46 15 over over IN cord-000580-dcid9emx 46 16 seven seven CD cord-000580-dcid9emx 46 17 different different JJ cord-000580-dcid9emx 46 18 phyla phylum NNS cord-000580-dcid9emx 46 19 ( ( -LRB- cord-000580-dcid9emx 46 20 See see VB cord-000580-dcid9emx 46 21 table table NN cord-000580-dcid9emx 46 22 S1 s1 NN cord-000580-dcid9emx 46 23 ) ) -RRB- cord-000580-dcid9emx 46 24 : : : cord-000580-dcid9emx 47 1 Acidobacteria Acidobacteria NNP cord-000580-dcid9emx 47 2 ( ( -LRB- cord-000580-dcid9emx 47 3 2 2 CD cord-000580-dcid9emx 47 4 genes gene NNS cord-000580-dcid9emx 47 5 ) ) -RRB- cord-000580-dcid9emx 47 6 , , , cord-000580-dcid9emx 47 7 Actinobacteria Actinobacteria NNP cord-000580-dcid9emx 47 8 ( ( -LRB- cord-000580-dcid9emx 47 9 43 43 CD cord-000580-dcid9emx 47 10 genes gene NNS cord-000580-dcid9emx 47 11 ) ) -RRB- cord-000580-dcid9emx 47 12 , , , cord-000580-dcid9emx 47 13 Cyanobacteria Cyanobacteria NNP cord-000580-dcid9emx 47 14 ( ( -LRB- cord-000580-dcid9emx 47 15 3 3 CD cord-000580-dcid9emx 47 16 genes gene NNS cord-000580-dcid9emx 47 17 ) ) -RRB- cord-000580-dcid9emx 47 18 , , , cord-000580-dcid9emx 47 19 TG1 TG1 NNP cord-000580-dcid9emx 47 20 ( ( -LRB- cord-000580-dcid9emx 47 21 1 1 CD cord-000580-dcid9emx 47 22 gene gene NN cord-000580-dcid9emx 47 23 ) ) -RRB- cord-000580-dcid9emx 47 24 , , , cord-000580-dcid9emx 47 25 Bacteroidetes Bacteroidetes NNP cord-000580-dcid9emx 47 26 ( ( -LRB- cord-000580-dcid9emx 47 27 2 2 CD cord-000580-dcid9emx 47 28 genes gene NNS cord-000580-dcid9emx 47 29 ) ) -RRB- cord-000580-dcid9emx 47 30 , , , cord-000580-dcid9emx 47 31 Firmicutes Firmicutes NNPS cord-000580-dcid9emx 47 32 ( ( -LRB- cord-000580-dcid9emx 47 33 1 1 CD cord-000580-dcid9emx 47 34 gene gene NN cord-000580-dcid9emx 47 35 ) ) -RRB- cord-000580-dcid9emx 47 36 and and CC cord-000580-dcid9emx 47 37 Proteobacteria Proteobacteria NNP cord-000580-dcid9emx 47 38 ( ( -LRB- cord-000580-dcid9emx 47 39 13 13 CD cord-000580-dcid9emx 47 40 genes gene NNS cord-000580-dcid9emx 47 41 ) ) -RRB- cord-000580-dcid9emx 47 42 . . . cord-000580-dcid9emx 48 1 Out out IN cord-000580-dcid9emx 48 2 of of IN cord-000580-dcid9emx 48 3 these these DT cord-000580-dcid9emx 48 4 , , , cord-000580-dcid9emx 48 5 46 46 CD cord-000580-dcid9emx 48 6 bacterial bacterial JJ cord-000580-dcid9emx 48 7 sequences sequence NNS cord-000580-dcid9emx 48 8 from from IN cord-000580-dcid9emx 48 9 32 32 CD cord-000580-dcid9emx 48 10 species specie NNS cord-000580-dcid9emx 48 11 were be VBD cord-000580-dcid9emx 48 12 included include VBN cord-000580-dcid9emx 48 13 for for IN cord-000580-dcid9emx 48 14 further further JJ cord-000580-dcid9emx 48 15 analysis analysis NN cord-000580-dcid9emx 48 16 . . . cord-000580-dcid9emx 49 1 No no DT cord-000580-dcid9emx 49 2 viral viral JJ cord-000580-dcid9emx 49 3 or or CC cord-000580-dcid9emx 49 4 Archaean archaean JJ cord-000580-dcid9emx 49 5 genes gene NNS cord-000580-dcid9emx 49 6 were be VBD cord-000580-dcid9emx 49 7 annotated annotate VBN cord-000580-dcid9emx 49 8 as as IN cord-000580-dcid9emx 49 9 IFITM IFITM NNP cord-000580-dcid9emx 49 10 homologues homologue NNS cord-000580-dcid9emx 49 11 in in IN cord-000580-dcid9emx 49 12 UniProt UniProt NNP cord-000580-dcid9emx 49 13 . . . cord-000580-dcid9emx 50 1 The the DT cord-000580-dcid9emx 50 2 phylogeny phylogeny NN cord-000580-dcid9emx 50 3 of of IN cord-000580-dcid9emx 50 4 the the DT cord-000580-dcid9emx 50 5 vertebrate vertebrate JJ cord-000580-dcid9emx 50 6 Dispanins Dispanins NNP cord-000580-dcid9emx 50 7 ( ( -LRB- cord-000580-dcid9emx 50 8 Figure figure NN cord-000580-dcid9emx 50 9 1 1 CD cord-000580-dcid9emx 50 10 ) ) -RRB- cord-000580-dcid9emx 50 11 allows allow VBZ cord-000580-dcid9emx 50 12 the the DT cord-000580-dcid9emx 50 13 division division NN cord-000580-dcid9emx 50 14 of of IN cord-000580-dcid9emx 50 15 the the DT cord-000580-dcid9emx 50 16 Dispanins Dispanins NNPS cord-000580-dcid9emx 50 17 into into IN cord-000580-dcid9emx 50 18 four four CD cord-000580-dcid9emx 50 19 subfamilies subfamily NNS cord-000580-dcid9emx 50 20 A a NN cord-000580-dcid9emx 50 21 - - HYPH cord-000580-dcid9emx 50 22 D d JJ cord-000580-dcid9emx 50 23 that that WDT cord-000580-dcid9emx 50 24 are be VBP cord-000580-dcid9emx 50 25 supported support VBN cord-000580-dcid9emx 50 26 by by IN cord-000580-dcid9emx 50 27 strong strong JJ cord-000580-dcid9emx 50 28 confidence confidence NN cord-000580-dcid9emx 50 29 with with IN cord-000580-dcid9emx 50 30 respect respect NN cord-000580-dcid9emx 50 31 to to IN cord-000580-dcid9emx 50 32 posterior posterior JJ cord-000580-dcid9emx 50 33 probabilities probability NNS cord-000580-dcid9emx 50 34 ( ( -LRB- cord-000580-dcid9emx 50 35 pp pp NNP cord-000580-dcid9emx 50 36 ) ) -RRB- cord-000580-dcid9emx 50 37 or or CC cord-000580-dcid9emx 50 38 bootstraps bootstrap NNS cord-000580-dcid9emx 50 39 ( ( -LRB- cord-000580-dcid9emx 50 40 pp.0.75 pp.0.75 VB cord-000580-dcid9emx 50 41 and and CC cord-000580-dcid9emx 50 42 bs.90 bs.90 NNP cord-000580-dcid9emx 50 43 % % NN cord-000580-dcid9emx 50 44 for for IN cord-000580-dcid9emx 50 45 all all DT cord-000580-dcid9emx 50 46 nodes node NNS cord-000580-dcid9emx 50 47 ) ) -RRB- cord-000580-dcid9emx 50 48 . . . cord-000580-dcid9emx 51 1 We -PRON- PRP cord-000580-dcid9emx 51 2 propose propose VBP cord-000580-dcid9emx 51 3 a a DT cord-000580-dcid9emx 51 4 common common JJ cord-000580-dcid9emx 51 5 nomenclature nomenclature NN cord-000580-dcid9emx 51 6 for for IN cord-000580-dcid9emx 51 7 the the DT cord-000580-dcid9emx 51 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 51 9 that that WDT cord-000580-dcid9emx 51 10 are be VBP cord-000580-dcid9emx 51 11 based base VBN cord-000580-dcid9emx 51 12 on on IN cord-000580-dcid9emx 51 13 their -PRON- PRP$ cord-000580-dcid9emx 51 14 subclass subclass NN cord-000580-dcid9emx 51 15 and and CC cord-000580-dcid9emx 51 16 a a DT cord-000580-dcid9emx 51 17 number number NN cord-000580-dcid9emx 51 18 ( ( -LRB- cord-000580-dcid9emx 51 19 DSPA1 dspa1 FW cord-000580-dcid9emx 51 20 etc etc FW cord-000580-dcid9emx 51 21 ) ) -RRB- cord-000580-dcid9emx 51 22 . . . cord-000580-dcid9emx 52 1 The the DT cord-000580-dcid9emx 52 2 proposed propose VBN cord-000580-dcid9emx 52 3 names name NNS cord-000580-dcid9emx 52 4 together together RB cord-000580-dcid9emx 52 5 with with IN cord-000580-dcid9emx 52 6 previous previous JJ cord-000580-dcid9emx 52 7 gene gene NN cord-000580-dcid9emx 52 8 symbols symbol NNS cord-000580-dcid9emx 52 9 and and CC cord-000580-dcid9emx 52 10 accession accession NN cord-000580-dcid9emx 52 11 number number NN cord-000580-dcid9emx 52 12 can can MD cord-000580-dcid9emx 52 13 be be VB cord-000580-dcid9emx 52 14 found find VBN cord-000580-dcid9emx 52 15 in in IN cord-000580-dcid9emx 52 16 Table Table NNP cord-000580-dcid9emx 52 17 S1 S1 NNP cord-000580-dcid9emx 52 18 . . . cord-000580-dcid9emx 53 1 The the DT cord-000580-dcid9emx 53 2 finding finding NN cord-000580-dcid9emx 53 3 of of IN cord-000580-dcid9emx 53 4 two two CD cord-000580-dcid9emx 53 5 Dispanin Dispanin NNP cord-000580-dcid9emx 53 6 homologs homolog NNS cord-000580-dcid9emx 53 7 in in IN cord-000580-dcid9emx 53 8 the the DT cord-000580-dcid9emx 53 9 brown brown JJ cord-000580-dcid9emx 53 10 alga alga NN cord-000580-dcid9emx 53 11 E. E. NNP cord-000580-dcid9emx 53 12 siliculosus siliculosus NNP cord-000580-dcid9emx 53 13 , , , cord-000580-dcid9emx 53 14 which which WDT cord-000580-dcid9emx 53 15 is be VBZ cord-000580-dcid9emx 53 16 evolutionary evolutionary JJ cord-000580-dcid9emx 53 17 distant distant JJ cord-000580-dcid9emx 53 18 to to IN cord-000580-dcid9emx 53 19 metazoa metazoa NNP cord-000580-dcid9emx 53 20 , , , cord-000580-dcid9emx 53 21 and and CC cord-000580-dcid9emx 53 22 the the DT cord-000580-dcid9emx 53 23 single single JJ cord-000580-dcid9emx 53 24 Dispanin Dispanin NNPS cord-000580-dcid9emx 53 25 in in IN cord-000580-dcid9emx 53 26 the the DT cord-000580-dcid9emx 53 27 close close JJ cord-000580-dcid9emx 53 28 metazoan metazoan NN cord-000580-dcid9emx 53 29 relative relative JJ cord-000580-dcid9emx 53 30 M.brevicollis m.brevicolli NNS cord-000580-dcid9emx 53 31 are be VBP cord-000580-dcid9emx 53 32 the the DT cord-000580-dcid9emx 53 33 two two CD cord-000580-dcid9emx 53 34 only only RB cord-000580-dcid9emx 53 35 non non JJ cord-000580-dcid9emx 53 36 - - JJ cord-000580-dcid9emx 53 37 metazoan metazoan JJ cord-000580-dcid9emx 53 38 eukaryotic eukaryotic JJ cord-000580-dcid9emx 53 39 Dispanins Dispanins NNPS cord-000580-dcid9emx 53 40 . . . cord-000580-dcid9emx 54 1 A a DT cord-000580-dcid9emx 54 2 BLAST blast NN cord-000580-dcid9emx 54 3 search search NN cord-000580-dcid9emx 54 4 gives give VBZ cord-000580-dcid9emx 54 5 that that IN cord-000580-dcid9emx 54 6 the the DT cord-000580-dcid9emx 54 7 E. E. NNP cord-000580-dcid9emx 54 8 siliculosus siliculosus NNP cord-000580-dcid9emx 54 9 proteins protein NNS cord-000580-dcid9emx 54 10 have have VBP cord-000580-dcid9emx 54 11 a a DT cord-000580-dcid9emx 54 12 higher high JJR cord-000580-dcid9emx 54 13 similarity similarity NN cord-000580-dcid9emx 54 14 to to IN cord-000580-dcid9emx 54 15 metazoan metazoan NN cord-000580-dcid9emx 54 16 family family NN cord-000580-dcid9emx 54 17 members member NNS cord-000580-dcid9emx 54 18 ( ( -LRB- cord-000580-dcid9emx 54 19 best well RBS cord-000580-dcid9emx 54 20 hit hit VBN cord-000580-dcid9emx 54 21 E e NN cord-000580-dcid9emx 54 22 - - NN cord-000580-dcid9emx 54 23 value,10 value,10 JJ cord-000580-dcid9emx 54 24 210 210 CD cord-000580-dcid9emx 54 25 ) ) -RRB- cord-000580-dcid9emx 54 26 than than IN cord-000580-dcid9emx 54 27 bacterial bacterial JJ cord-000580-dcid9emx 54 28 Dispanins Dispanins NNP cord-000580-dcid9emx 54 29 and and CC cord-000580-dcid9emx 54 30 M. M. NNP cord-000580-dcid9emx 54 31 brevicollis brevicollis NNP cord-000580-dcid9emx 54 32 . . . cord-000580-dcid9emx 55 1 The the DT cord-000580-dcid9emx 55 2 M. M. NNP cord-000580-dcid9emx 55 3 brevicollis brevicollis NNP cord-000580-dcid9emx 55 4 Dispanin Dispanin NNP cord-000580-dcid9emx 55 5 share share VBP cord-000580-dcid9emx 55 6 a a DT cord-000580-dcid9emx 55 7 conserved conserved JJ cord-000580-dcid9emx 55 8 splice splice NN cord-000580-dcid9emx 55 9 site site NN cord-000580-dcid9emx 55 10 with with IN cord-000580-dcid9emx 55 11 all all DT cord-000580-dcid9emx 55 12 metazoan metazoan NN cord-000580-dcid9emx 55 13 family family NN cord-000580-dcid9emx 55 14 members member NNS cord-000580-dcid9emx 55 15 , , , cord-000580-dcid9emx 55 16 which which WDT cord-000580-dcid9emx 55 17 suggest suggest VBP cord-000580-dcid9emx 55 18 that that IN cord-000580-dcid9emx 55 19 the the DT cord-000580-dcid9emx 55 20 eukaryotic eukaryotic JJ cord-000580-dcid9emx 55 21 Dispanins Dispanins NNPS cord-000580-dcid9emx 55 22 first first RB cord-000580-dcid9emx 55 23 emerged emerge VBD cord-000580-dcid9emx 55 24 in in IN cord-000580-dcid9emx 55 25 a a DT cord-000580-dcid9emx 55 26 common common JJ cord-000580-dcid9emx 55 27 ancestor ancestor NN cord-000580-dcid9emx 55 28 of of IN cord-000580-dcid9emx 55 29 M. M. NNP cord-000580-dcid9emx 55 30 brevicollis brevicollis NNP cord-000580-dcid9emx 55 31 and and CC cord-000580-dcid9emx 55 32 the the DT cord-000580-dcid9emx 55 33 metazoan metazoan NN cord-000580-dcid9emx 55 34 lineage lineage NN cord-000580-dcid9emx 55 35 . . . cord-000580-dcid9emx 56 1 Within within IN cord-000580-dcid9emx 56 2 the the DT cord-000580-dcid9emx 56 3 metazoan metazoan NN cord-000580-dcid9emx 56 4 lineage lineage NN cord-000580-dcid9emx 56 5 the the DT cord-000580-dcid9emx 56 6 Dispanins Dispanins NNPS cord-000580-dcid9emx 56 7 have have VBP cord-000580-dcid9emx 56 8 been be VBN cord-000580-dcid9emx 56 9 lost lose VBN cord-000580-dcid9emx 56 10 in in IN cord-000580-dcid9emx 56 11 at at RB cord-000580-dcid9emx 56 12 least least RBS cord-000580-dcid9emx 56 13 two two CD cord-000580-dcid9emx 56 14 separate separate JJ cord-000580-dcid9emx 56 15 occasions occasion NNS cord-000580-dcid9emx 56 16 , , , cord-000580-dcid9emx 56 17 i.e. i.e. FW cord-000580-dcid9emx 56 18 T. t. NN cord-000580-dcid9emx 56 19 adhaerens adhaerens NNP cord-000580-dcid9emx 56 20 and and CC cord-000580-dcid9emx 56 21 in in IN cord-000580-dcid9emx 56 22 the the DT cord-000580-dcid9emx 56 23 ecdysozoan ecdysozoan NNP cord-000580-dcid9emx 56 24 lineage lineage NNP cord-000580-dcid9emx 56 25 ( ( -LRB- cord-000580-dcid9emx 56 26 D. D. NNP cord-000580-dcid9emx 56 27 melanogaster melanogaster NNP cord-000580-dcid9emx 56 28 and and CC cord-000580-dcid9emx 56 29 C. C. NNP cord-000580-dcid9emx 56 30 elegans elegan NNS cord-000580-dcid9emx 56 31 ) ) -RRB- cord-000580-dcid9emx 56 32 . . . cord-000580-dcid9emx 57 1 The the DT cord-000580-dcid9emx 57 2 vertebrate vertebrate JJ cord-000580-dcid9emx 57 3 Dispanins Dispanins NNP cord-000580-dcid9emx 57 4 sort sort RB cord-000580-dcid9emx 57 5 into into IN cord-000580-dcid9emx 57 6 subfamilies subfamily NNS cord-000580-dcid9emx 58 1 A a LS cord-000580-dcid9emx 58 2 - - HYPH cord-000580-dcid9emx 58 3 D d JJ cord-000580-dcid9emx 58 4 ( ( -LRB- cord-000580-dcid9emx 58 5 Figure figure NN cord-000580-dcid9emx 58 6 1 1 CD cord-000580-dcid9emx 58 7 ) ) -RRB- cord-000580-dcid9emx 58 8 . . . cord-000580-dcid9emx 59 1 The the DT cord-000580-dcid9emx 59 2 DSPA DSPA NNP cord-000580-dcid9emx 59 3 subfamily subfamily NN cord-000580-dcid9emx 59 4 has have VBZ cord-000580-dcid9emx 59 5 six six CD cord-000580-dcid9emx 59 6 human human JJ cord-000580-dcid9emx 59 7 genes gene NNS cord-000580-dcid9emx 59 8 ( ( -LRB- cord-000580-dcid9emx 59 9 DSPA1 DSPA1 NNS cord-000580-dcid9emx 59 10 , , , cord-000580-dcid9emx 59 11 DSPA2a dspa2a NN cord-000580-dcid9emx 59 12 - - HYPH cord-000580-dcid9emx 59 13 d d JJ cord-000580-dcid9emx 59 14 and and CC cord-000580-dcid9emx 59 15 DSPA3 dspa3 NN cord-000580-dcid9emx 59 16 ) ) -RRB- cord-000580-dcid9emx 59 17 of of IN cord-000580-dcid9emx 59 18 which which WDT cord-000580-dcid9emx 59 19 the the DT cord-000580-dcid9emx 59 20 DSPA2a DSPA2a NNP cord-000580-dcid9emx 59 21 - - HYPH cord-000580-dcid9emx 59 22 c c NNP cord-000580-dcid9emx 59 23 corresponds correspond VBZ cord-000580-dcid9emx 59 24 to to IN cord-000580-dcid9emx 59 25 IFITM1 IFITM1 NNP cord-000580-dcid9emx 59 26 - - HYPH cord-000580-dcid9emx 59 27 3 3 CD cord-000580-dcid9emx 59 28 and and CC cord-000580-dcid9emx 59 29 DSPA1 DSPA1 NNS cord-000580-dcid9emx 59 30 to to IN cord-000580-dcid9emx 59 31 IFITM5 IFITM5 NNP cord-000580-dcid9emx 59 32 . . . cord-000580-dcid9emx 60 1 DSPA2d DSPA2d NNP cord-000580-dcid9emx 61 1 ( ( -LRB- cord-000580-dcid9emx 61 2 AC023157 AC023157 NNP cord-000580-dcid9emx 61 3 ) ) -RRB- cord-000580-dcid9emx 61 4 and and CC cord-000580-dcid9emx 61 5 DSPA3 dspa3 JJ cord-000580-dcid9emx 61 6 ( ( -LRB- cord-000580-dcid9emx 61 7 AC068580 ac068580 NN cord-000580-dcid9emx 61 8 ) ) -RRB- cord-000580-dcid9emx 61 9 are be VBP cord-000580-dcid9emx 61 10 two two CD cord-000580-dcid9emx 61 11 novel novel NN cord-000580-dcid9emx 61 12 identified identify VBN cord-000580-dcid9emx 61 13 genes gene NNS cord-000580-dcid9emx 61 14 , , , cord-000580-dcid9emx 61 15 closely closely RB cord-000580-dcid9emx 61 16 related related JJ cord-000580-dcid9emx 61 17 to to IN cord-000580-dcid9emx 61 18 the the DT cord-000580-dcid9emx 61 19 IFITM IFITM NNP cord-000580-dcid9emx 61 20 family family NN cord-000580-dcid9emx 61 21 . . . cord-000580-dcid9emx 62 1 The the DT cord-000580-dcid9emx 62 2 phylogenetic phylogenetic JJ cord-000580-dcid9emx 62 3 tree tree NN cord-000580-dcid9emx 62 4 indicates indicate VBZ cord-000580-dcid9emx 62 5 that that IN cord-000580-dcid9emx 62 6 the the DT cord-000580-dcid9emx 62 7 DSPA2 DSPA2 NNP cord-000580-dcid9emx 62 8 genes gene NNS cord-000580-dcid9emx 62 9 have have VBP cord-000580-dcid9emx 62 10 undergone undergo VBN cord-000580-dcid9emx 62 11 an an DT cord-000580-dcid9emx 62 12 independent independent JJ cord-000580-dcid9emx 62 13 duplication duplication NN cord-000580-dcid9emx 62 14 in in IN cord-000580-dcid9emx 62 15 H. H. NNP cord-000580-dcid9emx 62 16 Sapiens Sapiens NNP cord-000580-dcid9emx 62 17 and and CC cord-000580-dcid9emx 62 18 M. M. NNP cord-000580-dcid9emx 62 19 musculus musculus NN cord-000580-dcid9emx 62 20 and and CC cord-000580-dcid9emx 62 21 these these DT cord-000580-dcid9emx 62 22 were be VBD cord-000580-dcid9emx 62 23 given give VBN cord-000580-dcid9emx 62 24 a a DT cord-000580-dcid9emx 62 25 species species NN cord-000580-dcid9emx 62 26 specific specific JJ cord-000580-dcid9emx 62 27 nomenclature nomenclature NN cord-000580-dcid9emx 62 28 , , , cord-000580-dcid9emx 62 29 e.g. e.g. IN cord-000580-dcid9emx 62 30 DSPA2a dspa2a NN cord-000580-dcid9emx 62 31 - - HYPH cord-000580-dcid9emx 62 32 d d VBN cord-000580-dcid9emx 62 33 in in IN cord-000580-dcid9emx 62 34 human human NN cord-000580-dcid9emx 62 35 . . . cord-000580-dcid9emx 63 1 The the DT cord-000580-dcid9emx 63 2 Dspa4 dspa4 JJ cord-000580-dcid9emx 63 3 , , , cord-000580-dcid9emx 63 4 Dspa5 dspa5 JJ cord-000580-dcid9emx 63 5 , , , cord-000580-dcid9emx 63 6 Dspa6 dspa6 NN cord-000580-dcid9emx 63 7 genes gene NNS cord-000580-dcid9emx 63 8 in in IN cord-000580-dcid9emx 63 9 the the DT cord-000580-dcid9emx 63 10 phylogenetic phylogenetic JJ cord-000580-dcid9emx 63 11 tree tree NN cord-000580-dcid9emx 63 12 do do VBP cord-000580-dcid9emx 63 13 not not RB cord-000580-dcid9emx 63 14 have have VB cord-000580-dcid9emx 63 15 any any DT cord-000580-dcid9emx 63 16 clear clear JJ cord-000580-dcid9emx 63 17 human human JJ cord-000580-dcid9emx 63 18 orthologs ortholog NNS cord-000580-dcid9emx 63 19 . . . cord-000580-dcid9emx 64 1 The the DT cord-000580-dcid9emx 64 2 DSPB DSPB NNP cord-000580-dcid9emx 64 3 subfamily subfamily NN cord-000580-dcid9emx 64 4 is be VBZ cord-000580-dcid9emx 64 5 only only RB cord-000580-dcid9emx 64 6 found find VBN cord-000580-dcid9emx 64 7 in in IN cord-000580-dcid9emx 64 8 tetrapoda tetrapoda NNS cord-000580-dcid9emx 64 9 and and CC cord-000580-dcid9emx 64 10 contains contain VBZ cord-000580-dcid9emx 64 11 three three CD cord-000580-dcid9emx 64 12 human human JJ cord-000580-dcid9emx 64 13 genes gene NNS cord-000580-dcid9emx 64 14 called call VBN cord-000580-dcid9emx 64 15 DSPB1 DSPB1 NNP cord-000580-dcid9emx 64 16 ( ( -LRB- cord-000580-dcid9emx 64 17 TUSC5 TUSC5 NNP cord-000580-dcid9emx 64 18 ) ) -RRB- cord-000580-dcid9emx 64 19 , , , cord-000580-dcid9emx 64 20 DSPB2 DSPB2 NNP cord-000580-dcid9emx 65 1 ( ( -LRB- cord-000580-dcid9emx 65 2 TMEM233 TMEM233 NNP cord-000580-dcid9emx 65 3 ) ) -RRB- cord-000580-dcid9emx 65 4 and and CC cord-000580-dcid9emx 66 1 DSPB3 dspb3 XX cord-000580-dcid9emx 67 1 ( ( -LRB- cord-000580-dcid9emx 67 2 PRRT2 PRRT2 NNP cord-000580-dcid9emx 67 3 ) ) -RRB- cord-000580-dcid9emx 68 1 whereas whereas IN cord-000580-dcid9emx 68 2 Dspb4 Dspb4 NNP cord-000580-dcid9emx 68 3 is be VBZ cord-000580-dcid9emx 68 4 only only RB cord-000580-dcid9emx 68 5 present present JJ cord-000580-dcid9emx 68 6 in in IN cord-000580-dcid9emx 68 7 G. G. NNP cord-000580-dcid9emx 68 8 gallus gallus NN cord-000580-dcid9emx 68 9 . . . cord-000580-dcid9emx 69 1 DSPC1 DSPC1 NNP cord-000580-dcid9emx 70 1 ( ( -LRB- cord-000580-dcid9emx 70 2 TMEM90A TMEM90A NNP cord-000580-dcid9emx 70 3 ) ) -RRB- cord-000580-dcid9emx 70 4 , , , cord-000580-dcid9emx 70 5 DSPC2 dspc2 NN cord-000580-dcid9emx 70 6 ( ( -LRB- cord-000580-dcid9emx 70 7 TMEM90B TMEM90B NNP cord-000580-dcid9emx 70 8 ) ) -RRB- cord-000580-dcid9emx 70 9 and and CC cord-000580-dcid9emx 70 10 DSPC3 dspc3 FW cord-000580-dcid9emx 70 11 ( ( -LRB- cord-000580-dcid9emx 70 12 TMEM91 tmem91 ADD cord-000580-dcid9emx 70 13 ) ) -RRB- cord-000580-dcid9emx 70 14 make make VB cord-000580-dcid9emx 70 15 up up RP cord-000580-dcid9emx 70 16 the the DT cord-000580-dcid9emx 70 17 human human JJ cord-000580-dcid9emx 70 18 DSPC DSPC NNP cord-000580-dcid9emx 70 19 subfamily subfamily NN cord-000580-dcid9emx 70 20 , , , cord-000580-dcid9emx 70 21 which which WDT cord-000580-dcid9emx 70 22 is be VBZ cord-000580-dcid9emx 70 23 represented represent VBN cord-000580-dcid9emx 70 24 in in IN cord-000580-dcid9emx 70 25 all all DT cord-000580-dcid9emx 70 26 investigated investigate VBN cord-000580-dcid9emx 70 27 vertebrates vertebrate NNS cord-000580-dcid9emx 70 28 . . . cord-000580-dcid9emx 71 1 The the DT cord-000580-dcid9emx 71 2 DSPD1 dspd1 XX cord-000580-dcid9emx 71 3 ( ( -LRB- cord-000580-dcid9emx 71 4 PPRT1 PPRT1 NNP cord-000580-dcid9emx 71 5 ) ) -RRB- cord-000580-dcid9emx 71 6 gene gene NN cord-000580-dcid9emx 71 7 is be VBZ cord-000580-dcid9emx 71 8 found find VBN cord-000580-dcid9emx 71 9 in in IN cord-000580-dcid9emx 71 10 all all PDT cord-000580-dcid9emx 71 11 the the DT cord-000580-dcid9emx 71 12 vertebrate vertebrate JJ cord-000580-dcid9emx 71 13 species specie NNS cord-000580-dcid9emx 71 14 except except IN cord-000580-dcid9emx 71 15 the the DT cord-000580-dcid9emx 71 16 basal basal NN cord-000580-dcid9emx 71 17 organism organism NN cord-000580-dcid9emx 71 18 P. p. NN cord-000580-dcid9emx 71 19 marinus marinus NN cord-000580-dcid9emx 71 20 whereas whereas IN cord-000580-dcid9emx 71 21 DSPD2 DSPD2 NNP cord-000580-dcid9emx 72 1 ( ( -LRB- cord-000580-dcid9emx 72 2 AL160276 al160276 NN cord-000580-dcid9emx 72 3 ) ) -RRB- cord-000580-dcid9emx 72 4 is be VBZ cord-000580-dcid9emx 72 5 mammalian mammalian JJ cord-000580-dcid9emx 72 6 specific specific JJ cord-000580-dcid9emx 72 7 . . . cord-000580-dcid9emx 73 1 Five five CD cord-000580-dcid9emx 73 2 vertebrate vertebrate JJ cord-000580-dcid9emx 73 3 genes gene NNS cord-000580-dcid9emx 73 4 and and CC cord-000580-dcid9emx 73 5 all all DT cord-000580-dcid9emx 73 6 invertebrate invertebrate NN cord-000580-dcid9emx 73 7 were be VBD cord-000580-dcid9emx 73 8 excluded exclude VBN cord-000580-dcid9emx 73 9 from from IN cord-000580-dcid9emx 73 10 the the DT cord-000580-dcid9emx 73 11 phylogenetic phylogenetic JJ cord-000580-dcid9emx 73 12 analysis analysis NN cord-000580-dcid9emx 73 13 and and CC cord-000580-dcid9emx 73 14 instead instead RB cord-000580-dcid9emx 73 15 classified classify VBN cord-000580-dcid9emx 73 16 into into IN cord-000580-dcid9emx 73 17 subfamilies subfamily NNS cord-000580-dcid9emx 73 18 by by IN cord-000580-dcid9emx 73 19 using use VBG cord-000580-dcid9emx 73 20 a a DT cord-000580-dcid9emx 73 21 BLAST blast NN cord-000580-dcid9emx 73 22 approach approach NN cord-000580-dcid9emx 73 23 ( ( -LRB- cord-000580-dcid9emx 73 24 Table Table NNP cord-000580-dcid9emx 73 25 S1 S1 NNP cord-000580-dcid9emx 73 26 ) ) -RRB- cord-000580-dcid9emx 73 27 . . . cord-000580-dcid9emx 74 1 Some some DT cord-000580-dcid9emx 74 2 genes gene NNS cord-000580-dcid9emx 74 3 could could MD cord-000580-dcid9emx 74 4 not not RB cord-000580-dcid9emx 74 5 unambiguously unambiguously RB cord-000580-dcid9emx 74 6 be be VB cord-000580-dcid9emx 74 7 classified classify VBN cord-000580-dcid9emx 74 8 into into IN cord-000580-dcid9emx 74 9 the the DT cord-000580-dcid9emx 74 10 vertebrate vertebrate JJ cord-000580-dcid9emx 74 11 subfamilies subfamily NNS cord-000580-dcid9emx 74 12 : : : cord-000580-dcid9emx 74 13 C. C. NNP cord-000580-dcid9emx 74 14 intestinalis intestinalis NNP cord-000580-dcid9emx 74 15 ( ( -LRB- cord-000580-dcid9emx 74 16 1 1 CD cord-000580-dcid9emx 74 17 gene gene NN cord-000580-dcid9emx 74 18 ) ) -RRB- cord-000580-dcid9emx 74 19 , , , cord-000580-dcid9emx 74 20 S. S. NNP cord-000580-dcid9emx 74 21 mansoni mansoni NNP cord-000580-dcid9emx 74 22 ( ( -LRB- cord-000580-dcid9emx 74 23 1 1 CD cord-000580-dcid9emx 74 24 gene gene NN cord-000580-dcid9emx 74 25 ) ) -RRB- cord-000580-dcid9emx 74 26 , , , cord-000580-dcid9emx 74 27 B. B. NNP cord-000580-dcid9emx 74 28 floridae floridae NNP cord-000580-dcid9emx 74 29 ( ( -LRB- cord-000580-dcid9emx 74 30 2 2 CD cord-000580-dcid9emx 74 31 genes gene NNS cord-000580-dcid9emx 74 32 ) ) -RRB- cord-000580-dcid9emx 74 33 , , , cord-000580-dcid9emx 74 34 S. S. NNP cord-000580-dcid9emx 74 35 purpuratus purpuratus NN cord-000580-dcid9emx 74 36 ( ( -LRB- cord-000580-dcid9emx 74 37 3 3 CD cord-000580-dcid9emx 74 38 genes gene NNS cord-000580-dcid9emx 74 39 ) ) -RRB- cord-000580-dcid9emx 74 40 , , , cord-000580-dcid9emx 74 41 N. N. NNP cord-000580-dcid9emx 74 42 vectensis vectensis NN cord-000580-dcid9emx 74 43 ( ( -LRB- cord-000580-dcid9emx 74 44 1 1 CD cord-000580-dcid9emx 74 45 gene gene NN cord-000580-dcid9emx 74 46 ) ) -RRB- cord-000580-dcid9emx 74 47 and and CC cord-000580-dcid9emx 74 48 M. M. NNP cord-000580-dcid9emx 74 49 brevicollis brevicollis NNP cord-000580-dcid9emx 74 50 ( ( -LRB- cord-000580-dcid9emx 74 51 1 1 CD cord-000580-dcid9emx 74 52 gene gene NN cord-000580-dcid9emx 74 53 ) ) -RRB- cord-000580-dcid9emx 74 54 . . . cord-000580-dcid9emx 75 1 By by IN cord-000580-dcid9emx 75 2 combining combine VBG cord-000580-dcid9emx 75 3 the the DT cord-000580-dcid9emx 75 4 results result NNS cord-000580-dcid9emx 75 5 of of IN cord-000580-dcid9emx 75 6 the the DT cord-000580-dcid9emx 75 7 phylogenetic phylogenetic JJ cord-000580-dcid9emx 75 8 analysis analysis NN cord-000580-dcid9emx 75 9 and and CC cord-000580-dcid9emx 75 10 BLAST blast NN cord-000580-dcid9emx 75 11 classification classification NN cord-000580-dcid9emx 75 12 , , , cord-000580-dcid9emx 75 13 we -PRON- PRP cord-000580-dcid9emx 75 14 created create VBD cord-000580-dcid9emx 75 15 a a DT cord-000580-dcid9emx 75 16 schematic schematic JJ cord-000580-dcid9emx 75 17 overview overview NN cord-000580-dcid9emx 75 18 of of IN cord-000580-dcid9emx 75 19 the the DT cord-000580-dcid9emx 75 20 organisms organism NNS cord-000580-dcid9emx 75 21 ' ' POS cord-000580-dcid9emx 75 22 gene gene NN cord-000580-dcid9emx 75 23 repertoire repertoire NN cord-000580-dcid9emx 75 24 and and CC cord-000580-dcid9emx 75 25 a a DT cord-000580-dcid9emx 75 26 schematic schematic JJ cord-000580-dcid9emx 75 27 picture picture NN cord-000580-dcid9emx 75 28 of of IN cord-000580-dcid9emx 75 29 the the DT cord-000580-dcid9emx 75 30 Dispanin Dispanin NNP cord-000580-dcid9emx 75 31 family family NN cord-000580-dcid9emx 75 32 's 's POS cord-000580-dcid9emx 75 33 evolutionary evolutionary JJ cord-000580-dcid9emx 75 34 history history NN cord-000580-dcid9emx 75 35 , , , cord-000580-dcid9emx 75 36 which which WDT cord-000580-dcid9emx 75 37 suggests suggest VBZ cord-000580-dcid9emx 75 38 that that IN cord-000580-dcid9emx 75 39 the the DT cord-000580-dcid9emx 75 40 invertebrate invertebrate JJ cord-000580-dcid9emx 75 41 Dispanins Dispanins NNPS cord-000580-dcid9emx 75 42 share share VBP cord-000580-dcid9emx 75 43 more more JJR cord-000580-dcid9emx 75 44 similarity similarity NN cord-000580-dcid9emx 75 45 towards towards IN cord-000580-dcid9emx 75 46 the the DT cord-000580-dcid9emx 75 47 DSPC DSPC NNP cord-000580-dcid9emx 75 48 and and CC cord-000580-dcid9emx 75 49 D d NN cord-000580-dcid9emx 75 50 subfamilies subfamily NNS cord-000580-dcid9emx 75 51 than than IN cord-000580-dcid9emx 75 52 DSPA DSPA NNP cord-000580-dcid9emx 75 53 and and CC cord-000580-dcid9emx 75 54 B B NNP cord-000580-dcid9emx 75 55 ( ( -LRB- cord-000580-dcid9emx 75 56 Figure figure NN cord-000580-dcid9emx 75 57 2 2 CD cord-000580-dcid9emx 75 58 ) ) -RRB- cord-000580-dcid9emx 75 59 . . . cord-000580-dcid9emx 76 1 All all PDT cord-000580-dcid9emx 76 2 the the DT cord-000580-dcid9emx 76 3 members member NNS cord-000580-dcid9emx 76 4 of of IN cord-000580-dcid9emx 76 5 the the DT cord-000580-dcid9emx 76 6 human human JJ cord-000580-dcid9emx 76 7 DSPA DSPA NNP cord-000580-dcid9emx 76 8 are be VBP cord-000580-dcid9emx 76 9 located locate VBN cord-000580-dcid9emx 76 10 on on IN cord-000580-dcid9emx 76 11 chromosome chromosome NN cord-000580-dcid9emx 76 12 11 11 CD cord-000580-dcid9emx 76 13 except except IN cord-000580-dcid9emx 76 14 for for IN cord-000580-dcid9emx 76 15 DSPA2d dspa2d NN cord-000580-dcid9emx 76 16 which which WDT cord-000580-dcid9emx 76 17 resides reside VBZ cord-000580-dcid9emx 76 18 on on IN cord-000580-dcid9emx 76 19 chromosome chromosome NN cord-000580-dcid9emx 76 20 12 12 CD cord-000580-dcid9emx 76 21 . . . cord-000580-dcid9emx 77 1 The the DT cord-000580-dcid9emx 77 2 genes gene NNS cord-000580-dcid9emx 77 3 of of IN cord-000580-dcid9emx 77 4 the the DT cord-000580-dcid9emx 77 5 other other JJ cord-000580-dcid9emx 77 6 subfamilies subfamily NNS cord-000580-dcid9emx 77 7 are be VBP cord-000580-dcid9emx 77 8 not not RB cord-000580-dcid9emx 77 9 enriched enrich VBN cord-000580-dcid9emx 77 10 on on IN cord-000580-dcid9emx 77 11 any any DT cord-000580-dcid9emx 77 12 chromosome chromosome NN cord-000580-dcid9emx 77 13 . . . cord-000580-dcid9emx 78 1 Several several JJ cord-000580-dcid9emx 78 2 features feature NNS cord-000580-dcid9emx 78 3 are be VBP cord-000580-dcid9emx 78 4 common common JJ cord-000580-dcid9emx 78 5 to to IN cord-000580-dcid9emx 78 6 all all PDT cord-000580-dcid9emx 78 7 the the DT cord-000580-dcid9emx 78 8 eukaryotic eukaryotic JJ cord-000580-dcid9emx 78 9 Dispanin Dispanin NNP cord-000580-dcid9emx 78 10 proteins protein NNS cord-000580-dcid9emx 78 11 ( ( -LRB- cord-000580-dcid9emx 78 12 Figure figure NN cord-000580-dcid9emx 78 13 3 3 CD cord-000580-dcid9emx 78 14 ) ) -RRB- cord-000580-dcid9emx 78 15 . . . cord-000580-dcid9emx 79 1 They -PRON- PRP cord-000580-dcid9emx 79 2 comprise comprise VBP cord-000580-dcid9emx 79 3 two two CD cord-000580-dcid9emx 79 4 transmembrane transmembrane NN cord-000580-dcid9emx 79 5 helices helix NNS cord-000580-dcid9emx 79 6 that that WDT cord-000580-dcid9emx 79 7 are be VBP cord-000580-dcid9emx 79 8 predicted predict VBN cord-000580-dcid9emx 79 9 between between IN cord-000580-dcid9emx 79 10 20 20 CD cord-000580-dcid9emx 79 11 and and CC cord-000580-dcid9emx 79 12 30 30 CD cord-000580-dcid9emx 79 13 amino amino NN cord-000580-dcid9emx 79 14 acids acid NNS cord-000580-dcid9emx 79 15 in in IN cord-000580-dcid9emx 79 16 length length NN cord-000580-dcid9emx 79 17 with with IN cord-000580-dcid9emx 79 18 the the DT cord-000580-dcid9emx 79 19 second second JJ cord-000580-dcid9emx 79 20 helices helix NNS cord-000580-dcid9emx 79 21 often often RB cord-000580-dcid9emx 79 22 being be VBG cord-000580-dcid9emx 79 23 slightly slightly RB cord-000580-dcid9emx 79 24 longer long JJR cord-000580-dcid9emx 79 25 . . . cord-000580-dcid9emx 80 1 The the DT cord-000580-dcid9emx 80 2 Dispanins Dispanins NNPS cord-000580-dcid9emx 80 3 are be VBP cord-000580-dcid9emx 80 4 rich rich JJ cord-000580-dcid9emx 80 5 in in IN cord-000580-dcid9emx 80 6 both both DT cord-000580-dcid9emx 80 7 glycosylation glycosylation NN cord-000580-dcid9emx 80 8 - - HYPH cord-000580-dcid9emx 80 9 and and CC cord-000580-dcid9emx 80 10 phosphorylation phosphorylation NN cord-000580-dcid9emx 80 11 sites site NNS cord-000580-dcid9emx 80 12 that that WDT cord-000580-dcid9emx 80 13 predominantly predominantly RB cord-000580-dcid9emx 80 14 are be VBP cord-000580-dcid9emx 80 15 found find VBN cord-000580-dcid9emx 80 16 on on IN cord-000580-dcid9emx 80 17 the the DT cord-000580-dcid9emx 80 18 Nterminus Nterminus NNP cord-000580-dcid9emx 80 19 . . . cord-000580-dcid9emx 81 1 The the DT cord-000580-dcid9emx 81 2 N N NNP cord-000580-dcid9emx 81 3 - - HYPH cord-000580-dcid9emx 81 4 terminus terminus NN cord-000580-dcid9emx 81 5 is be VBZ cord-000580-dcid9emx 81 6 often often RB cord-000580-dcid9emx 81 7 long long JJ cord-000580-dcid9emx 81 8 ( ( -LRB- cord-000580-dcid9emx 81 9 .100 .100 NFP cord-000580-dcid9emx 81 10 amino amino JJ cord-000580-dcid9emx 81 11 acids acid NNS cord-000580-dcid9emx 81 12 ) ) -RRB- cord-000580-dcid9emx 81 13 compared compare VBN cord-000580-dcid9emx 81 14 to to IN cord-000580-dcid9emx 81 15 the the DT cord-000580-dcid9emx 81 16 C c NN cord-000580-dcid9emx 81 17 - - HYPH cord-000580-dcid9emx 81 18 terminal terminal NN cord-000580-dcid9emx 81 19 ( ( -LRB- cord-000580-dcid9emx 81 20 , , , cord-000580-dcid9emx 81 21 10 10 CD cord-000580-dcid9emx 81 22 amino amino JJ cord-000580-dcid9emx 81 23 acids acid NNS cord-000580-dcid9emx 81 24 ) ) -RRB- cord-000580-dcid9emx 81 25 and and CC cord-000580-dcid9emx 81 26 both both DT cord-000580-dcid9emx 81 27 are be VBP cord-000580-dcid9emx 81 28 always always RB cord-000580-dcid9emx 81 29 oriented orient VBN cord-000580-dcid9emx 81 30 towards towards IN cord-000580-dcid9emx 81 31 the the DT cord-000580-dcid9emx 81 32 outside outside NN cord-000580-dcid9emx 81 33 of of IN cord-000580-dcid9emx 81 34 the the DT cord-000580-dcid9emx 81 35 cell cell NN cord-000580-dcid9emx 81 36 . . . cord-000580-dcid9emx 82 1 The the DT cord-000580-dcid9emx 82 2 Dispanins Dispanins NNPS cord-000580-dcid9emx 82 3 contain contain VBP cord-000580-dcid9emx 82 4 several several JJ cord-000580-dcid9emx 82 5 conserved conserve VBN cord-000580-dcid9emx 82 6 motifs motif NNS cord-000580-dcid9emx 82 7 ( ( -LRB- cord-000580-dcid9emx 82 8 Figure figure NN cord-000580-dcid9emx 82 9 3 3 CD cord-000580-dcid9emx 82 10 and and CC cord-000580-dcid9emx 82 11 4 4 CD cord-000580-dcid9emx 82 12 ) ) -RRB- cord-000580-dcid9emx 82 13 , , , cord-000580-dcid9emx 82 14 which which WDT cord-000580-dcid9emx 82 15 are be VBP cord-000580-dcid9emx 82 16 found find VBN cord-000580-dcid9emx 82 17 both both DT cord-000580-dcid9emx 82 18 among among IN cord-000580-dcid9emx 82 19 eukaryotes eukaryote NNS cord-000580-dcid9emx 82 20 and and CC cord-000580-dcid9emx 82 21 bacteria bacteria NNS cord-000580-dcid9emx 82 22 . . . cord-000580-dcid9emx 83 1 The the DT cord-000580-dcid9emx 83 2 most most RBS cord-000580-dcid9emx 83 3 conserved conserved JJ cord-000580-dcid9emx 83 4 pattern pattern NN cord-000580-dcid9emx 83 5 is be VBZ cord-000580-dcid9emx 83 6 the the DT cord-000580-dcid9emx 83 7 G G NNP cord-000580-dcid9emx 83 8 - - HYPH cord-000580-dcid9emx 83 9 D d JJ cord-000580-dcid9emx 83 10 motif motif NN cord-000580-dcid9emx 83 11 and and CC cord-000580-dcid9emx 83 12 the the DT cord-000580-dcid9emx 83 13 A A NNP cord-000580-dcid9emx 83 14 - - HYPH cord-000580-dcid9emx 83 15 X(6)-A x(6)-a NN cord-000580-dcid9emx 83 16 motif motif NN cord-000580-dcid9emx 83 17 , , , cord-000580-dcid9emx 83 18 both both DT cord-000580-dcid9emx 83 19 situated situate VBN cord-000580-dcid9emx 83 20 in in IN cord-000580-dcid9emx 83 21 the the DT cord-000580-dcid9emx 83 22 intracellular intracellular JJ cord-000580-dcid9emx 83 23 loop loop NN cord-000580-dcid9emx 83 24 between between IN cord-000580-dcid9emx 83 25 the the DT cord-000580-dcid9emx 83 26 transmembrane transmembrane NN cord-000580-dcid9emx 83 27 helices helix NNS cord-000580-dcid9emx 83 28 that that WDT cord-000580-dcid9emx 83 29 also also RB cord-000580-dcid9emx 83 30 is be VBZ cord-000580-dcid9emx 83 31 frequently frequently RB cord-000580-dcid9emx 83 32 rich rich JJ cord-000580-dcid9emx 83 33 in in IN cord-000580-dcid9emx 83 34 positive positive JJ cord-000580-dcid9emx 83 35 amino amino NN cord-000580-dcid9emx 83 36 acids acid NNS cord-000580-dcid9emx 83 37 ( ( -LRB- cord-000580-dcid9emx 83 38 K K NNP cord-000580-dcid9emx 83 39 and and CC cord-000580-dcid9emx 83 40 R R NNP cord-000580-dcid9emx 83 41 ) ) -RRB- cord-000580-dcid9emx 83 42 . . . cord-000580-dcid9emx 84 1 The the DT cord-000580-dcid9emx 84 2 first first JJ cord-000580-dcid9emx 84 3 helix helix NN cord-000580-dcid9emx 84 4 is be VBZ cord-000580-dcid9emx 84 5 the the DT cord-000580-dcid9emx 84 6 most most RBS cord-000580-dcid9emx 84 7 conserved conserve VBN cord-000580-dcid9emx 84 8 with with IN cord-000580-dcid9emx 84 9 an an DT cord-000580-dcid9emx 84 10 alanine alanine NN cord-000580-dcid9emx 84 11 ( ( -LRB- cord-000580-dcid9emx 84 12 A a NN cord-000580-dcid9emx 84 13 ) ) -RRB- cord-000580-dcid9emx 84 14 residue residue NN cord-000580-dcid9emx 84 15 and and CC cord-000580-dcid9emx 84 16 double double JJ cord-000580-dcid9emx 84 17 cysteine cysteine NN cord-000580-dcid9emx 84 18 C c NN cord-000580-dcid9emx 84 19 - - HYPH cord-000580-dcid9emx 84 20 C C NNP cord-000580-dcid9emx 84 21 ( ( -LRB- cord-000580-dcid9emx 84 22 C C NNP cord-000580-dcid9emx 84 23 - - HYPH cord-000580-dcid9emx 84 24 F F NNP cord-000580-dcid9emx 84 25 - - HYPH cord-000580-dcid9emx 84 26 C C NNP cord-000580-dcid9emx 84 27 in in IN cord-000580-dcid9emx 84 28 the the DT cord-000580-dcid9emx 84 29 DSPB DSPB NNP cord-000580-dcid9emx 84 30 family family NN cord-000580-dcid9emx 84 31 ) ) -RRB- cord-000580-dcid9emx 84 32 motif motif NN cord-000580-dcid9emx 84 33 whereas whereas IN cord-000580-dcid9emx 84 34 a a DT cord-000580-dcid9emx 84 35 glycine glycine NN cord-000580-dcid9emx 84 36 ( ( -LRB- cord-000580-dcid9emx 84 37 G g NN cord-000580-dcid9emx 84 38 ) ) -RRB- cord-000580-dcid9emx 84 39 residue residue NN cord-000580-dcid9emx 84 40 is be VBZ cord-000580-dcid9emx 84 41 the the DT cord-000580-dcid9emx 84 42 most most RBS cord-000580-dcid9emx 84 43 conserved conserve VBN cord-000580-dcid9emx 84 44 in in IN cord-000580-dcid9emx 84 45 the the DT cord-000580-dcid9emx 84 46 second second JJ cord-000580-dcid9emx 84 47 helix helix NN cord-000580-dcid9emx 84 48 . . . cord-000580-dcid9emx 85 1 Another another DT cord-000580-dcid9emx 85 2 highly highly RB cord-000580-dcid9emx 85 3 conserved conserve VBN cord-000580-dcid9emx 85 4 motif motif NN cord-000580-dcid9emx 85 5 , , , cord-000580-dcid9emx 85 6 though though IN cord-000580-dcid9emx 85 7 only only RB cord-000580-dcid9emx 85 8 amongst amongst IN cord-000580-dcid9emx 85 9 the the DT cord-000580-dcid9emx 85 10 eukaryotes eukaryote NNS cord-000580-dcid9emx 85 11 , , , cord-000580-dcid9emx 85 12 is be VBZ cord-000580-dcid9emx 85 13 the the DT cord-000580-dcid9emx 85 14 single single JJ cord-000580-dcid9emx 85 15 aspartic aspartic JJ cord-000580-dcid9emx 85 16 acid acid NN cord-000580-dcid9emx 85 17 ( ( -LRB- cord-000580-dcid9emx 85 18 D D NNP cord-000580-dcid9emx 85 19 ) ) -RRB- cord-000580-dcid9emx 85 20 on on IN cord-000580-dcid9emx 85 21 the the DT cord-000580-dcid9emx 85 22 N N NNP cord-000580-dcid9emx 85 23 - - HYPH cord-000580-dcid9emx 85 24 terminus terminus NN cord-000580-dcid9emx 85 25 , , , cord-000580-dcid9emx 85 26 flanking flank VBG cord-000580-dcid9emx 85 27 the the DT cord-000580-dcid9emx 85 28 first first JJ cord-000580-dcid9emx 85 29 helix helix NN cord-000580-dcid9emx 85 30 . . . cord-000580-dcid9emx 86 1 Analysis analysis NN cord-000580-dcid9emx 86 2 of of IN cord-000580-dcid9emx 86 3 the the DT cord-000580-dcid9emx 86 4 exon exon NN cord-000580-dcid9emx 86 5 structure structure NN cord-000580-dcid9emx 86 6 in in IN cord-000580-dcid9emx 86 7 the the DT cord-000580-dcid9emx 86 8 protein protein NN cord-000580-dcid9emx 86 9 sequences sequence NNS cord-000580-dcid9emx 86 10 was be VBD cord-000580-dcid9emx 86 11 made make VBN cord-000580-dcid9emx 86 12 for for IN cord-000580-dcid9emx 86 13 all all DT cord-000580-dcid9emx 86 14 eukaryotic eukaryotic JJ cord-000580-dcid9emx 86 15 Dispanins Dispanins NNPS cord-000580-dcid9emx 86 16 except except IN cord-000580-dcid9emx 86 17 E. E. NNP cord-000580-dcid9emx 86 18 siliculosus siliculosus NNP cord-000580-dcid9emx 86 19 where where WRB cord-000580-dcid9emx 86 20 no no DT cord-000580-dcid9emx 86 21 such such JJ cord-000580-dcid9emx 86 22 information information NN cord-000580-dcid9emx 86 23 was be VBD cord-000580-dcid9emx 86 24 found find VBN cord-000580-dcid9emx 86 25 . . . cord-000580-dcid9emx 87 1 The the DT cord-000580-dcid9emx 87 2 eukaryotic eukaryotic JJ cord-000580-dcid9emx 87 3 Dispanins Dispanins NNPS cord-000580-dcid9emx 87 4 have have VBP cord-000580-dcid9emx 87 5 a a DT cord-000580-dcid9emx 87 6 conserved conserved JJ cord-000580-dcid9emx 87 7 splice splice NN cord-000580-dcid9emx 87 8 site site NN cord-000580-dcid9emx 87 9 in in IN cord-000580-dcid9emx 87 10 the the DT cord-000580-dcid9emx 87 11 intracellular intracellular JJ cord-000580-dcid9emx 87 12 loop loop NN cord-000580-dcid9emx 87 13 that that WDT cord-000580-dcid9emx 87 14 separates separate VBZ cord-000580-dcid9emx 87 15 the the DT cord-000580-dcid9emx 87 16 two two CD cord-000580-dcid9emx 87 17 transmembrane transmembrane NN cord-000580-dcid9emx 87 18 helices helix NNS cord-000580-dcid9emx 87 19 into into IN cord-000580-dcid9emx 87 20 different different JJ cord-000580-dcid9emx 87 21 exons exon NNS cord-000580-dcid9emx 87 22 ( ( -LRB- cord-000580-dcid9emx 87 23 Figure figure NN cord-000580-dcid9emx 87 24 4 4 CD cord-000580-dcid9emx 87 25 ) ) -RRB- cord-000580-dcid9emx 87 26 . . . cord-000580-dcid9emx 88 1 This this DT cord-000580-dcid9emx 88 2 site site NN cord-000580-dcid9emx 88 3 is be VBZ cord-000580-dcid9emx 88 4 only only RB cord-000580-dcid9emx 88 5 missing miss VBG cord-000580-dcid9emx 88 6 in in IN cord-000580-dcid9emx 88 7 the the DT cord-000580-dcid9emx 88 8 S. S. NNP cord-000580-dcid9emx 88 9 mansoni mansoni NNP cord-000580-dcid9emx 88 10 Dispanin Dispanin NNP cord-000580-dcid9emx 88 11 and and CC cord-000580-dcid9emx 88 12 the the DT cord-000580-dcid9emx 88 13 mouse mouse NN cord-000580-dcid9emx 88 14 Dspa2f Dspa2f NNP cord-000580-dcid9emx 88 15 genes gene NNS cord-000580-dcid9emx 88 16 . . . cord-000580-dcid9emx 89 1 The the DT cord-000580-dcid9emx 89 2 vertebrate vertebrate JJ cord-000580-dcid9emx 89 3 proteins protein NNS cord-000580-dcid9emx 89 4 of of IN cord-000580-dcid9emx 89 5 the the DT cord-000580-dcid9emx 89 6 DSPA DSPA NNP cord-000580-dcid9emx 89 7 and and CC cord-000580-dcid9emx 89 8 DSPB DSPB NNP cord-000580-dcid9emx 89 9 subfamilies subfamily NNS cord-000580-dcid9emx 89 10 only only RB cord-000580-dcid9emx 89 11 have have VBP cord-000580-dcid9emx 89 12 these these DT cord-000580-dcid9emx 89 13 two two CD cord-000580-dcid9emx 89 14 exons exon NNS cord-000580-dcid9emx 89 15 whereas whereas IN cord-000580-dcid9emx 89 16 the the DT cord-000580-dcid9emx 89 17 whole whole JJ cord-000580-dcid9emx 89 18 DSPC DSPC NNP cord-000580-dcid9emx 89 19 subfamily subfamily NN cord-000580-dcid9emx 89 20 and and CC cord-000580-dcid9emx 89 21 the the DT cord-000580-dcid9emx 89 22 DSPD1 dspd1 NN cord-000580-dcid9emx 89 23 proteins protein NNS cord-000580-dcid9emx 89 24 have have VBP cord-000580-dcid9emx 89 25 an an DT cord-000580-dcid9emx 89 26 additional additional JJ cord-000580-dcid9emx 89 27 exon exon NN cord-000580-dcid9emx 89 28 that that IN cord-000580-dcid9emx 89 29 codes code NNS cord-000580-dcid9emx 89 30 for for IN cord-000580-dcid9emx 89 31 their -PRON- PRP$ cord-000580-dcid9emx 89 32 N n CD cord-000580-dcid9emx 89 33 - - HYPH cord-000580-dcid9emx 89 34 terminus terminus NN cord-000580-dcid9emx 89 35 . . . cord-000580-dcid9emx 90 1 The the DT cord-000580-dcid9emx 90 2 DSPD2 dspd2 NN cord-000580-dcid9emx 90 3 proteins protein NNS cord-000580-dcid9emx 90 4 that that IN cord-000580-dcid9emx 90 5 only only RB cord-000580-dcid9emx 90 6 are be VBP cord-000580-dcid9emx 90 7 found find VBN cord-000580-dcid9emx 90 8 in in IN cord-000580-dcid9emx 90 9 mammals mammal NNS cord-000580-dcid9emx 90 10 seem seem VBP cord-000580-dcid9emx 90 11 to to TO cord-000580-dcid9emx 90 12 have have VB cord-000580-dcid9emx 90 13 lost lose VBN cord-000580-dcid9emx 90 14 their -PRON- PRP$ cord-000580-dcid9emx 90 15 N n CD cord-000580-dcid9emx 90 16 - - HYPH cord-000580-dcid9emx 90 17 termini termini NN cord-000580-dcid9emx 90 18 exon exon NN cord-000580-dcid9emx 90 19 . . . cord-000580-dcid9emx 91 1 All all PDT cord-000580-dcid9emx 91 2 the the DT cord-000580-dcid9emx 91 3 classified classified JJ cord-000580-dcid9emx 91 4 B. B. NNP cord-000580-dcid9emx 91 5 floridae floridae NN cord-000580-dcid9emx 91 6 and and CC cord-000580-dcid9emx 91 7 S. S. NNP cord-000580-dcid9emx 91 8 purpuratus purpuratus NNP cord-000580-dcid9emx 91 9 sequences sequence NNS cord-000580-dcid9emx 91 10 has have VBZ cord-000580-dcid9emx 91 11 the the DT cord-000580-dcid9emx 91 12 corresponding corresponding JJ cord-000580-dcid9emx 91 13 splice splice NN cord-000580-dcid9emx 91 14 site site NN cord-000580-dcid9emx 91 15 in in IN cord-000580-dcid9emx 91 16 the the DT cord-000580-dcid9emx 91 17 N N NNP cord-000580-dcid9emx 91 18 - - HYPH cord-000580-dcid9emx 91 19 terminus terminus NN cord-000580-dcid9emx 91 20 , , , cord-000580-dcid9emx 91 21 whereas whereas IN cord-000580-dcid9emx 91 22 the the DT cord-000580-dcid9emx 91 23 N. N. NNP cord-000580-dcid9emx 91 24 vectensis vectensis NN cord-000580-dcid9emx 91 25 and and CC cord-000580-dcid9emx 91 26 M. M. NNP cord-000580-dcid9emx 91 27 brevicollis brevicollis FW cord-000580-dcid9emx 91 28 proteins protein NNS cord-000580-dcid9emx 91 29 has have VBZ cord-000580-dcid9emx 91 30 3 3 CD cord-000580-dcid9emx 91 31 - - SYM cord-000580-dcid9emx 91 32 6 6 CD cord-000580-dcid9emx 91 33 and and CC cord-000580-dcid9emx 91 34 7 7 CD cord-000580-dcid9emx 91 35 exons exon NNS cord-000580-dcid9emx 91 36 respectively respectively RB cord-000580-dcid9emx 91 37 . . . cord-000580-dcid9emx 92 1 We -PRON- PRP cord-000580-dcid9emx 92 2 provide provide VBP cord-000580-dcid9emx 92 3 evidence evidence NN cord-000580-dcid9emx 92 4 that that IN cord-000580-dcid9emx 92 5 the the DT cord-000580-dcid9emx 92 6 four four CD cord-000580-dcid9emx 92 7 IFITM IFITM NNP cord-000580-dcid9emx 92 8 genes gene NNS cord-000580-dcid9emx 92 9 together together RB cord-000580-dcid9emx 92 10 with with IN cord-000580-dcid9emx 92 11 ten ten CD cord-000580-dcid9emx 92 12 additional additional JJ cord-000580-dcid9emx 92 13 human human JJ cord-000580-dcid9emx 92 14 genes gene NNS cord-000580-dcid9emx 92 15 , , , cord-000580-dcid9emx 92 16 known know VBN cord-000580-dcid9emx 92 17 as as IN cord-000580-dcid9emx 92 18 TUSC5 TUSC5 NNP cord-000580-dcid9emx 92 19 , , , cord-000580-dcid9emx 92 20 TMEM233 TMEM233 NNP cord-000580-dcid9emx 92 21 , , , cord-000580-dcid9emx 92 22 PRRT2 PRRT2 NNP cord-000580-dcid9emx 92 23 , , , cord-000580-dcid9emx 92 24 TMEM90A TMEM90A NNS cord-000580-dcid9emx 92 25 , , , cord-000580-dcid9emx 92 26 DSPC2 dspc2 NN cord-000580-dcid9emx 92 27 , , , cord-000580-dcid9emx 92 28 TMEM90B TMEM90B NNP cord-000580-dcid9emx 92 29 , , , cord-000580-dcid9emx 92 30 TMEM91 tmem91 ADD cord-000580-dcid9emx 92 31 , , , cord-000580-dcid9emx 92 32 AC023157 AC023157 NNP cord-000580-dcid9emx 92 33 , , , cord-000580-dcid9emx 92 34 AL160276 al160276 NN cord-000580-dcid9emx 92 35 and and CC cord-000580-dcid9emx 92 36 AC068580 ac068580 RB cord-000580-dcid9emx 92 37 , , , cord-000580-dcid9emx 92 38 form form VB cord-000580-dcid9emx 92 39 a a DT cord-000580-dcid9emx 92 40 novel novel JJ cord-000580-dcid9emx 92 41 gene gene NN cord-000580-dcid9emx 92 42 family family NN cord-000580-dcid9emx 92 43 that that WDT cord-000580-dcid9emx 92 44 we -PRON- PRP cord-000580-dcid9emx 92 45 call call VBP cord-000580-dcid9emx 92 46 the the DT cord-000580-dcid9emx 92 47 Dispanins Dispanins NNPS cord-000580-dcid9emx 92 48 , , , cord-000580-dcid9emx 92 49 which which WDT cord-000580-dcid9emx 92 50 refers refer VBZ cord-000580-dcid9emx 92 51 to to IN cord-000580-dcid9emx 92 52 the the DT cord-000580-dcid9emx 92 53 2TM 2tm CD cord-000580-dcid9emx 92 54 membrane membrane NN cord-000580-dcid9emx 92 55 topology topology NN cord-000580-dcid9emx 92 56 that that WDT cord-000580-dcid9emx 92 57 is be VBZ cord-000580-dcid9emx 92 58 common common JJ cord-000580-dcid9emx 92 59 to to IN cord-000580-dcid9emx 92 60 all all DT cord-000580-dcid9emx 92 61 identified identify VBN cord-000580-dcid9emx 92 62 members member NNS cord-000580-dcid9emx 92 63 . . . cord-000580-dcid9emx 93 1 This this DT cord-000580-dcid9emx 93 2 family family NN cord-000580-dcid9emx 93 3 is be VBZ cord-000580-dcid9emx 93 4 the the DT cord-000580-dcid9emx 93 5 second second RB cord-000580-dcid9emx 93 6 largest large JJS cord-000580-dcid9emx 93 7 2TM 2tm CD cord-000580-dcid9emx 93 8 family family NN cord-000580-dcid9emx 93 9 in in IN cord-000580-dcid9emx 93 10 the the DT cord-000580-dcid9emx 93 11 human human JJ cord-000580-dcid9emx 93 12 genome genome NN cord-000580-dcid9emx 93 13 , , , cord-000580-dcid9emx 93 14 superseded supersede VBN cord-000580-dcid9emx 93 15 only only RB cord-000580-dcid9emx 93 16 by by IN cord-000580-dcid9emx 93 17 the the DT cord-000580-dcid9emx 93 18 Inwardly inwardly RB cord-000580-dcid9emx 93 19 rectifying rectify VBG cord-000580-dcid9emx 93 20 potassium potassium NN cord-000580-dcid9emx 93 21 channel channel NN cord-000580-dcid9emx 93 22 family family NN cord-000580-dcid9emx 93 23 that that WDT cord-000580-dcid9emx 93 24 has have VBZ cord-000580-dcid9emx 93 25 15 15 CD cord-000580-dcid9emx 93 26 members member NNS cord-000580-dcid9emx 93 27 [ [ -LRB- cord-000580-dcid9emx 93 28 2 2 CD cord-000580-dcid9emx 93 29 ] ] -RRB- cord-000580-dcid9emx 93 30 . . . cord-000580-dcid9emx 94 1 Except except IN cord-000580-dcid9emx 94 2 for for IN cord-000580-dcid9emx 94 3 the the DT cord-000580-dcid9emx 94 4 2TM 2tm CD cord-000580-dcid9emx 94 5 memebrane memebrane NN cord-000580-dcid9emx 94 6 topology topology NN cord-000580-dcid9emx 94 7 the the DT cord-000580-dcid9emx 94 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 94 9 are be VBP cord-000580-dcid9emx 94 10 not not RB cord-000580-dcid9emx 94 11 homologous homologous JJ cord-000580-dcid9emx 94 12 or or CC cord-000580-dcid9emx 94 13 share share VB cord-000580-dcid9emx 94 14 domains domain NNS cord-000580-dcid9emx 94 15 with with IN cord-000580-dcid9emx 94 16 any any DT cord-000580-dcid9emx 94 17 other other JJ cord-000580-dcid9emx 94 18 2TM 2tm CD cord-000580-dcid9emx 94 19 proteins protein NNS cord-000580-dcid9emx 94 20 in in IN cord-000580-dcid9emx 94 21 the the DT cord-000580-dcid9emx 94 22 human human JJ cord-000580-dcid9emx 94 23 genome genome NN cord-000580-dcid9emx 94 24 and and CC cord-000580-dcid9emx 94 25 constitute constitute VB cord-000580-dcid9emx 94 26 a a DT cord-000580-dcid9emx 94 27 distinct distinct JJ cord-000580-dcid9emx 94 28 gene gene NN cord-000580-dcid9emx 94 29 family family NN cord-000580-dcid9emx 94 30 . . . cord-000580-dcid9emx 95 1 We -PRON- PRP cord-000580-dcid9emx 95 2 have have VBP cord-000580-dcid9emx 95 3 discovered discover VBN cord-000580-dcid9emx 95 4 that that IN cord-000580-dcid9emx 95 5 this this DT cord-000580-dcid9emx 95 6 family family NN cord-000580-dcid9emx 95 7 is be VBZ cord-000580-dcid9emx 95 8 found find VBN cord-000580-dcid9emx 95 9 in in IN cord-000580-dcid9emx 95 10 metazoan metazoan NN cord-000580-dcid9emx 95 11 , , , cord-000580-dcid9emx 95 12 the the DT cord-000580-dcid9emx 95 13 choanoflagellate choanoflagellate NN cord-000580-dcid9emx 95 14 M. M. NNP cord-000580-dcid9emx 95 15 brevicollis brevicollis NNP cord-000580-dcid9emx 95 16 and and CC cord-000580-dcid9emx 95 17 the the DT cord-000580-dcid9emx 95 18 brown brown JJ cord-000580-dcid9emx 95 19 alga alga NN cord-000580-dcid9emx 95 20 E. E. NNP cord-000580-dcid9emx 95 21 siliculosus siliculosus NNP cord-000580-dcid9emx 95 22 , , , cord-000580-dcid9emx 95 23 but but CC cord-000580-dcid9emx 95 24 not not RB cord-000580-dcid9emx 95 25 in in IN cord-000580-dcid9emx 95 26 other other JJ cord-000580-dcid9emx 95 27 eukaryotes eukaryote NNS cord-000580-dcid9emx 95 28 . . . cord-000580-dcid9emx 96 1 Surprisingly surprisingly RB cord-000580-dcid9emx 96 2 it -PRON- PRP cord-000580-dcid9emx 96 3 is be VBZ cord-000580-dcid9emx 96 4 widely widely RB cord-000580-dcid9emx 96 5 present present JJ cord-000580-dcid9emx 96 6 in in IN cord-000580-dcid9emx 96 7 bacteria bacteria NNS cord-000580-dcid9emx 96 8 where where WRB cord-000580-dcid9emx 96 9 it -PRON- PRP cord-000580-dcid9emx 96 10 is be VBZ cord-000580-dcid9emx 96 11 found find VBN cord-000580-dcid9emx 96 12 in in IN cord-000580-dcid9emx 96 13 several several JJ cord-000580-dcid9emx 96 14 different different JJ cord-000580-dcid9emx 96 15 phyla phylum NNS cord-000580-dcid9emx 96 16 such such JJ cord-000580-dcid9emx 96 17 as as IN cord-000580-dcid9emx 96 18 Actinobacteridae Actinobacteridae NNP cord-000580-dcid9emx 96 19 , , , cord-000580-dcid9emx 96 20 Acidobacteria Acidobacteria NNP cord-000580-dcid9emx 96 21 , , , cord-000580-dcid9emx 96 22 Cyanobacteria Cyanobacteria NNP cord-000580-dcid9emx 96 23 , , , cord-000580-dcid9emx 96 24 Bacteriodetes Bacteriodetes NNP cord-000580-dcid9emx 96 25 , , , cord-000580-dcid9emx 96 26 Firmicutes Firmicutes NNPS cord-000580-dcid9emx 96 27 and and CC cord-000580-dcid9emx 96 28 Proteobacteria Proteobacteria NNP cord-000580-dcid9emx 96 29 . . . cord-000580-dcid9emx 97 1 The the DT cord-000580-dcid9emx 97 2 highest high JJS cord-000580-dcid9emx 97 3 number number NN cord-000580-dcid9emx 97 4 of of IN cord-000580-dcid9emx 97 5 bacterial bacterial JJ cord-000580-dcid9emx 97 6 Dispanins Dispanins NNPS cord-000580-dcid9emx 97 7 is be VBZ cord-000580-dcid9emx 97 8 detected detect VBN cord-000580-dcid9emx 97 9 in in IN cord-000580-dcid9emx 97 10 Actinobacteria Actinobacteria NNP cord-000580-dcid9emx 97 11 and and CC cord-000580-dcid9emx 97 12 Proteobacteria Proteobacteria NNP cord-000580-dcid9emx 97 13 , , , cord-000580-dcid9emx 97 14 which which WDT cord-000580-dcid9emx 97 15 diverged diverge VBD cord-000580-dcid9emx 97 16 around around RB cord-000580-dcid9emx 97 17 three three CD cord-000580-dcid9emx 97 18 billion billion CD cord-000580-dcid9emx 97 19 years year NNS cord-000580-dcid9emx 97 20 ago ago RB cord-000580-dcid9emx 97 21 [ [ -LRB- cord-000580-dcid9emx 97 22 15 15 CD cord-000580-dcid9emx 97 23 ] ] -RRB- cord-000580-dcid9emx 97 24 . . . cord-000580-dcid9emx 98 1 We -PRON- PRP cord-000580-dcid9emx 98 2 find find VBP cord-000580-dcid9emx 98 3 that that IN cord-000580-dcid9emx 98 4 Dispanins Dispanins NNP cord-000580-dcid9emx 98 5 in in IN cord-000580-dcid9emx 98 6 eukaryotes eukaryote NNS cord-000580-dcid9emx 98 7 and and CC cord-000580-dcid9emx 98 8 bacteria bacteria NNS cord-000580-dcid9emx 98 9 have have VBP cord-000580-dcid9emx 98 10 high high JJ cord-000580-dcid9emx 98 11 sequence sequence NN cord-000580-dcid9emx 98 12 similarities similarity NNS cord-000580-dcid9emx 98 13 and and CC cord-000580-dcid9emx 98 14 share share VB cord-000580-dcid9emx 98 15 several several JJ cord-000580-dcid9emx 98 16 conserved conserve VBN cord-000580-dcid9emx 98 17 sequence sequence NN cord-000580-dcid9emx 98 18 motifs motif NNS cord-000580-dcid9emx 98 19 ( ( -LRB- cord-000580-dcid9emx 98 20 Figure figure NN cord-000580-dcid9emx 98 21 4 4 CD cord-000580-dcid9emx 98 22 ) ) -RRB- cord-000580-dcid9emx 98 23 , , , cord-000580-dcid9emx 98 24 which which WDT cord-000580-dcid9emx 98 25 is be VBZ cord-000580-dcid9emx 98 26 strong strong JJ cord-000580-dcid9emx 98 27 evidence evidence NN cord-000580-dcid9emx 98 28 for for IN cord-000580-dcid9emx 98 29 a a DT cord-000580-dcid9emx 98 30 common common JJ cord-000580-dcid9emx 98 31 evolutionary evolutionary JJ cord-000580-dcid9emx 98 32 origin origin NN cord-000580-dcid9emx 98 33 and and CC cord-000580-dcid9emx 98 34 possibly possibly RB cord-000580-dcid9emx 98 35 a a DT cord-000580-dcid9emx 98 36 functional functional JJ cord-000580-dcid9emx 98 37 relationship relationship NN cord-000580-dcid9emx 98 38 . . . cord-000580-dcid9emx 99 1 As as IN cord-000580-dcid9emx 99 2 the the DT cord-000580-dcid9emx 99 3 family family NN cord-000580-dcid9emx 99 4 is be VBZ cord-000580-dcid9emx 99 5 found find VBN cord-000580-dcid9emx 99 6 in in IN cord-000580-dcid9emx 99 7 several several JJ cord-000580-dcid9emx 99 8 bacterial bacterial JJ cord-000580-dcid9emx 99 9 phyla phylum NNS cord-000580-dcid9emx 99 10 we -PRON- PRP cord-000580-dcid9emx 99 11 suggest suggest VBP cord-000580-dcid9emx 99 12 that that IN cord-000580-dcid9emx 99 13 it -PRON- PRP cord-000580-dcid9emx 99 14 first first RB cord-000580-dcid9emx 99 15 emerged emerge VBD cord-000580-dcid9emx 99 16 in in IN cord-000580-dcid9emx 99 17 bacteria bacteria NNS cord-000580-dcid9emx 99 18 to to TO cord-000580-dcid9emx 99 19 later later RB cord-000580-dcid9emx 99 20 be be VB cord-000580-dcid9emx 99 21 introduced introduce VBN cord-000580-dcid9emx 99 22 in in IN cord-000580-dcid9emx 99 23 eukaryotes eukaryote NNS cord-000580-dcid9emx 99 24 through through IN cord-000580-dcid9emx 99 25 a a DT cord-000580-dcid9emx 99 26 horizontal horizontal JJ cord-000580-dcid9emx 99 27 gene gene NN cord-000580-dcid9emx 99 28 transfer transfer NN cord-000580-dcid9emx 99 29 event event NN cord-000580-dcid9emx 99 30 . . . cord-000580-dcid9emx 100 1 However however RB cord-000580-dcid9emx 100 2 , , , cord-000580-dcid9emx 100 3 we -PRON- PRP cord-000580-dcid9emx 100 4 were be VBD cord-000580-dcid9emx 100 5 not not RB cord-000580-dcid9emx 100 6 able able JJ cord-000580-dcid9emx 100 7 to to TO cord-000580-dcid9emx 100 8 construct construct VB cord-000580-dcid9emx 100 9 a a DT cord-000580-dcid9emx 100 10 stable stable JJ cord-000580-dcid9emx 100 11 phylogenetic phylogenetic JJ cord-000580-dcid9emx 100 12 tree tree NN cord-000580-dcid9emx 100 13 including include VBG cord-000580-dcid9emx 100 14 bacterial bacterial JJ cord-000580-dcid9emx 100 15 and and CC cord-000580-dcid9emx 100 16 eukaryotic eukaryotic JJ cord-000580-dcid9emx 100 17 Dispanins Dispanins NNPS cord-000580-dcid9emx 100 18 . . . cord-000580-dcid9emx 101 1 As as IN cord-000580-dcid9emx 101 2 the the DT cord-000580-dcid9emx 101 3 eukaryotic eukaryotic JJ cord-000580-dcid9emx 101 4 Dispanins Dispanins NNPS cord-000580-dcid9emx 101 5 only only RB cord-000580-dcid9emx 101 6 is be VBZ cord-000580-dcid9emx 101 7 widespread widespread JJ cord-000580-dcid9emx 101 8 in in IN cord-000580-dcid9emx 101 9 metazoa metazoa NNP cord-000580-dcid9emx 101 10 it -PRON- PRP cord-000580-dcid9emx 101 11 was be VBD cord-000580-dcid9emx 101 12 unexpected unexpected JJ cord-000580-dcid9emx 101 13 to to TO cord-000580-dcid9emx 101 14 find find VB cord-000580-dcid9emx 101 15 the the DT cord-000580-dcid9emx 101 16 family family NN cord-000580-dcid9emx 101 17 in in IN cord-000580-dcid9emx 101 18 the the DT cord-000580-dcid9emx 101 19 evolutionary evolutionary JJ cord-000580-dcid9emx 101 20 distant distant JJ cord-000580-dcid9emx 101 21 brown brown JJ cord-000580-dcid9emx 101 22 alga alga NN cord-000580-dcid9emx 101 23 E. E. NNP cord-000580-dcid9emx 101 24 siliculosus siliculosus NNP cord-000580-dcid9emx 101 25 ( ( -LRB- cord-000580-dcid9emx 101 26 Figure figure NN cord-000580-dcid9emx 101 27 2 2 CD cord-000580-dcid9emx 101 28 ) ) -RRB- cord-000580-dcid9emx 101 29 . . . cord-000580-dcid9emx 102 1 Our -PRON- PRP$ cord-000580-dcid9emx 102 2 sequence sequence NN cord-000580-dcid9emx 102 3 analysis analysis NN cord-000580-dcid9emx 102 4 supports support VBZ cord-000580-dcid9emx 102 5 that that IN cord-000580-dcid9emx 102 6 all all DT cord-000580-dcid9emx 102 7 metazoan metazoan NNS cord-000580-dcid9emx 102 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 102 9 have have VBP cord-000580-dcid9emx 102 10 their -PRON- PRP$ cord-000580-dcid9emx 102 11 origin origin NN cord-000580-dcid9emx 102 12 in in IN cord-000580-dcid9emx 102 13 the the DT cord-000580-dcid9emx 102 14 common common JJ cord-000580-dcid9emx 102 15 ancestor ancestor NN cord-000580-dcid9emx 102 16 of of IN cord-000580-dcid9emx 102 17 M. M. NNP cord-000580-dcid9emx 102 18 brevicollis brevicollis NNP cord-000580-dcid9emx 102 19 and and CC cord-000580-dcid9emx 102 20 metazoa metazoa NNP cord-000580-dcid9emx 102 21 as as IN cord-000580-dcid9emx 102 22 the the DT cord-000580-dcid9emx 102 23 choanoflagellate choanoflagellate NN cord-000580-dcid9emx 102 24 share share VBP cord-000580-dcid9emx 102 25 a a DT cord-000580-dcid9emx 102 26 conserved conserved JJ cord-000580-dcid9emx 102 27 splice splice NN cord-000580-dcid9emx 102 28 site site NN cord-000580-dcid9emx 102 29 in in IN cord-000580-dcid9emx 102 30 the the DT cord-000580-dcid9emx 102 31 intracellular intracellular JJ cord-000580-dcid9emx 102 32 loop loop NN cord-000580-dcid9emx 102 33 with with IN cord-000580-dcid9emx 102 34 nearly nearly RB cord-000580-dcid9emx 102 35 all all DT cord-000580-dcid9emx 102 36 metazoan metazoan NN cord-000580-dcid9emx 102 37 Dispanins Dispanins NNPS cord-000580-dcid9emx 102 38 ( ( -LRB- cord-000580-dcid9emx 102 39 Figure Figure NNP cord-000580-dcid9emx 102 40 4 4 CD cord-000580-dcid9emx 102 41 ) ) -RRB- cord-000580-dcid9emx 102 42 . . . cord-000580-dcid9emx 103 1 However however RB cord-000580-dcid9emx 103 2 , , , cord-000580-dcid9emx 103 3 the the DT cord-000580-dcid9emx 103 4 finding finding NN cord-000580-dcid9emx 103 5 of of IN cord-000580-dcid9emx 103 6 the the DT cord-000580-dcid9emx 103 7 family family NN cord-000580-dcid9emx 103 8 in in IN cord-000580-dcid9emx 103 9 E. E. NNP cord-000580-dcid9emx 103 10 siliculosus siliculosus NNP cord-000580-dcid9emx 103 11 suggests suggest VBZ cord-000580-dcid9emx 103 12 that that IN cord-000580-dcid9emx 103 13 the the DT cord-000580-dcid9emx 103 14 family family NN cord-000580-dcid9emx 103 15 has have VBZ cord-000580-dcid9emx 103 16 undergone undergo VBN cord-000580-dcid9emx 103 17 two two CD cord-000580-dcid9emx 103 18 horizontal horizontal JJ cord-000580-dcid9emx 103 19 gene gene NN cord-000580-dcid9emx 103 20 transfer transfer NN cord-000580-dcid9emx 103 21 events event NNS cord-000580-dcid9emx 103 22 . . . cord-000580-dcid9emx 104 1 As as IN cord-000580-dcid9emx 104 2 the the DT cord-000580-dcid9emx 104 3 E. E. NNP cord-000580-dcid9emx 104 4 siliculosus siliculosus NNP cord-000580-dcid9emx 104 5 Dispanins Dispanins NNP cord-000580-dcid9emx 104 6 are be VBP cord-000580-dcid9emx 104 7 more more RBR cord-000580-dcid9emx 104 8 similar similar JJ cord-000580-dcid9emx 104 9 to to IN cord-000580-dcid9emx 104 10 metazoan metazoan JJ cord-000580-dcid9emx 104 11 family family NN cord-000580-dcid9emx 104 12 members member NNS cord-000580-dcid9emx 104 13 than than IN cord-000580-dcid9emx 104 14 M. M. NNP cord-000580-dcid9emx 104 15 brevicollis brevicollis NNP cord-000580-dcid9emx 104 16 and and CC cord-000580-dcid9emx 104 17 bacteria bacteria NNS cord-000580-dcid9emx 104 18 we -PRON- PRP cord-000580-dcid9emx 104 19 propose propose VBP cord-000580-dcid9emx 104 20 that that IN cord-000580-dcid9emx 104 21 the the DT cord-000580-dcid9emx 104 22 first first JJ cord-000580-dcid9emx 104 23 horizontal horizontal JJ cord-000580-dcid9emx 104 24 gene gene NN cord-000580-dcid9emx 104 25 transfer transfer NN cord-000580-dcid9emx 104 26 event event NN cord-000580-dcid9emx 104 27 was be VBD cord-000580-dcid9emx 104 28 from from IN cord-000580-dcid9emx 104 29 bacteria bacteria NNS cord-000580-dcid9emx 104 30 to to IN cord-000580-dcid9emx 104 31 a a DT cord-000580-dcid9emx 104 32 common common JJ cord-000580-dcid9emx 104 33 ancestor ancestor NN cord-000580-dcid9emx 104 34 of of IN cord-000580-dcid9emx 104 35 choanoflagellates choanoflagellate NNS cord-000580-dcid9emx 104 36 and and CC cord-000580-dcid9emx 104 37 metazoa metazoa NNP cord-000580-dcid9emx 104 38 followed follow VBN cord-000580-dcid9emx 104 39 by by IN cord-000580-dcid9emx 104 40 a a DT cord-000580-dcid9emx 104 41 second second JJ cord-000580-dcid9emx 104 42 transfer transfer NN cord-000580-dcid9emx 104 43 between between IN cord-000580-dcid9emx 104 44 metazoa metazoa JJ cord-000580-dcid9emx 104 45 and and CC cord-000580-dcid9emx 104 46 brown brown JJ cord-000580-dcid9emx 104 47 alga alga NN cord-000580-dcid9emx 104 48 . . . cord-000580-dcid9emx 105 1 During during IN cord-000580-dcid9emx 105 2 the the DT cord-000580-dcid9emx 105 3 course course NN cord-000580-dcid9emx 105 4 of of IN cord-000580-dcid9emx 105 5 metazoan metazoan NN cord-000580-dcid9emx 105 6 evolution evolution NN cord-000580-dcid9emx 105 7 the the DT cord-000580-dcid9emx 105 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 105 9 have have VBP cord-000580-dcid9emx 105 10 expanded expand VBN cord-000580-dcid9emx 105 11 and and CC cord-000580-dcid9emx 105 12 diverged diverge VBN cord-000580-dcid9emx 105 13 into into IN cord-000580-dcid9emx 105 14 four four CD cord-000580-dcid9emx 105 15 distinct distinct JJ cord-000580-dcid9emx 105 16 subfamilies subfamily NNS cord-000580-dcid9emx 105 17 . . . cord-000580-dcid9emx 106 1 However however RB cord-000580-dcid9emx 106 2 , , , cord-000580-dcid9emx 106 3 it -PRON- PRP cord-000580-dcid9emx 106 4 has have VBZ cord-000580-dcid9emx 106 5 also also RB cord-000580-dcid9emx 106 6 been be VBN cord-000580-dcid9emx 106 7 lost lose VBN cord-000580-dcid9emx 106 8 in in IN cord-000580-dcid9emx 106 9 the the DT cord-000580-dcid9emx 106 10 basal basal NN cord-000580-dcid9emx 106 11 metazoa metazoa NNP cord-000580-dcid9emx 106 12 T. T. NNP cord-000580-dcid9emx 106 13 adhaerens adhaerens NNP cord-000580-dcid9emx 106 14 and and CC cord-000580-dcid9emx 106 15 the the DT cord-000580-dcid9emx 106 16 ecdysozoan ecdysozoan NNP cord-000580-dcid9emx 106 17 lineage lineage NNP cord-000580-dcid9emx 106 18 , , , cord-000580-dcid9emx 106 19 which which WDT cord-000580-dcid9emx 106 20 show show VBP cord-000580-dcid9emx 106 21 that that IN cord-000580-dcid9emx 106 22 it -PRON- PRP cord-000580-dcid9emx 106 23 is be VBZ cord-000580-dcid9emx 106 24 not not RB cord-000580-dcid9emx 106 25 essential essential JJ cord-000580-dcid9emx 106 26 for for IN cord-000580-dcid9emx 106 27 all all DT cord-000580-dcid9emx 106 28 metazoan metazoan JJ cord-000580-dcid9emx 106 29 life life NN cord-000580-dcid9emx 106 30 . . . cord-000580-dcid9emx 107 1 Although although IN cord-000580-dcid9emx 107 2 we -PRON- PRP cord-000580-dcid9emx 107 3 were be VBD cord-000580-dcid9emx 107 4 unable unable JJ cord-000580-dcid9emx 107 5 to to TO cord-000580-dcid9emx 107 6 create create VB cord-000580-dcid9emx 107 7 a a DT cord-000580-dcid9emx 107 8 stable stable JJ cord-000580-dcid9emx 107 9 phylogenetic phylogenetic JJ cord-000580-dcid9emx 107 10 tree tree NN cord-000580-dcid9emx 107 11 that that WDT cord-000580-dcid9emx 107 12 include include VBP cord-000580-dcid9emx 107 13 both both DT cord-000580-dcid9emx 107 14 vertebrate vertebrate JJ cord-000580-dcid9emx 107 15 and and CC cord-000580-dcid9emx 107 16 invertebrate invertebrate JJ cord-000580-dcid9emx 107 17 sequences sequence NNS cord-000580-dcid9emx 107 18 BLAST blast VBP cord-000580-dcid9emx 107 19 searches search NNS cord-000580-dcid9emx 107 20 suggest suggest VBP cord-000580-dcid9emx 107 21 that that IN cord-000580-dcid9emx 107 22 the the DT cord-000580-dcid9emx 107 23 DSPC DSPC NNP cord-000580-dcid9emx 107 24 and and CC cord-000580-dcid9emx 107 25 D d NN cord-000580-dcid9emx 107 26 subfamilies subfamily NNS cord-000580-dcid9emx 107 27 are be VBP cord-000580-dcid9emx 107 28 the the DT cord-000580-dcid9emx 107 29 oldest old JJS cord-000580-dcid9emx 107 30 of of IN cord-000580-dcid9emx 107 31 the the DT cord-000580-dcid9emx 107 32 vertebrate vertebrate JJ cord-000580-dcid9emx 107 33 subfamilies subfamily NNS cord-000580-dcid9emx 107 34 as as IN cord-000580-dcid9emx 107 35 the the DT cord-000580-dcid9emx 107 36 invertebrate invertebrate NN cord-000580-dcid9emx 107 37 sequences sequence NNS cord-000580-dcid9emx 107 38 has have VBZ cord-000580-dcid9emx 107 39 higher high JJR cord-000580-dcid9emx 107 40 resemblance resemblance NN cord-000580-dcid9emx 107 41 to to IN cord-000580-dcid9emx 107 42 these these DT cord-000580-dcid9emx 107 43 two two CD cord-000580-dcid9emx 107 44 subfamilies subfamily NNS cord-000580-dcid9emx 107 45 ( ( -LRB- cord-000580-dcid9emx 107 46 Figure figure NN cord-000580-dcid9emx 107 47 2 2 CD cord-000580-dcid9emx 107 48 ) ) -RRB- cord-000580-dcid9emx 107 49 . . . cord-000580-dcid9emx 108 1 Moreover moreover RB cord-000580-dcid9emx 108 2 , , , cord-000580-dcid9emx 108 3 the the DT cord-000580-dcid9emx 108 4 DSPC DSPC NNP cord-000580-dcid9emx 108 5 and and CC cord-000580-dcid9emx 108 6 D D NNP cord-000580-dcid9emx 108 7 subfamilies subfamily NNS cord-000580-dcid9emx 108 8 forms form VBZ cord-000580-dcid9emx 108 9 a a DT cord-000580-dcid9emx 108 10 separate separate JJ cord-000580-dcid9emx 108 11 cluster cluster NN cord-000580-dcid9emx 108 12 from from IN cord-000580-dcid9emx 108 13 DSPA DSPA NNP cord-000580-dcid9emx 108 14 - - HYPH cord-000580-dcid9emx 108 15 B B NNP cord-000580-dcid9emx 108 16 ( ( -LRB- cord-000580-dcid9emx 108 17 Figure figure NN cord-000580-dcid9emx 108 18 1 1 CD cord-000580-dcid9emx 108 19 ) ) -RRB- cord-000580-dcid9emx 108 20 . . . cord-000580-dcid9emx 109 1 Hence hence RB cord-000580-dcid9emx 109 2 , , , cord-000580-dcid9emx 109 3 the the DT cord-000580-dcid9emx 109 4 phylogenetic phylogenetic JJ cord-000580-dcid9emx 109 5 analysis analysis NN cord-000580-dcid9emx 109 6 suggests suggest VBZ cord-000580-dcid9emx 109 7 that that IN cord-000580-dcid9emx 109 8 the the DT cord-000580-dcid9emx 109 9 DSPA DSPA NNP cord-000580-dcid9emx 109 10 and and CC cord-000580-dcid9emx 109 11 B B NNP cord-000580-dcid9emx 109 12 subfamilies subfamily NNS cord-000580-dcid9emx 109 13 have have VBP cord-000580-dcid9emx 109 14 their -PRON- PRP$ cord-000580-dcid9emx 109 15 origin origin NN cord-000580-dcid9emx 109 16 close close RB cord-000580-dcid9emx 109 17 to to IN cord-000580-dcid9emx 109 18 the the DT cord-000580-dcid9emx 109 19 radiation radiation NN cord-000580-dcid9emx 109 20 of of IN cord-000580-dcid9emx 109 21 teleost teleost NN cord-000580-dcid9emx 109 22 , , , cord-000580-dcid9emx 109 23 although although IN cord-000580-dcid9emx 109 24 DSPB DSPB NNP cord-000580-dcid9emx 109 25 have have VBP cord-000580-dcid9emx 109 26 been be VBN cord-000580-dcid9emx 109 27 lost lose VBN cord-000580-dcid9emx 109 28 in in IN cord-000580-dcid9emx 109 29 D. D. NNP cord-000580-dcid9emx 109 30 rerio rerio NNP cord-000580-dcid9emx 109 31 ( ( -LRB- cord-000580-dcid9emx 109 32 Figure figure NN cord-000580-dcid9emx 109 33 1 1 CD cord-000580-dcid9emx 109 34 and and CC cord-000580-dcid9emx 109 35 4 4 CD cord-000580-dcid9emx 109 36 ) ) -RRB- cord-000580-dcid9emx 109 37 . . . cord-000580-dcid9emx 110 1 The the DT cord-000580-dcid9emx 110 2 DSPC DSPC NNP cord-000580-dcid9emx 110 3 family family NN cord-000580-dcid9emx 110 4 is be VBZ cord-000580-dcid9emx 110 5 found find VBN cord-000580-dcid9emx 110 6 in in IN cord-000580-dcid9emx 110 7 two two CD cord-000580-dcid9emx 110 8 to to TO cord-000580-dcid9emx 110 9 three three CD cord-000580-dcid9emx 110 10 copies copy NNS cord-000580-dcid9emx 110 11 in in IN cord-000580-dcid9emx 110 12 all all DT cord-000580-dcid9emx 110 13 vertebrates vertebrate NNS cord-000580-dcid9emx 110 14 and and CC cord-000580-dcid9emx 110 15 is be VBZ cord-000580-dcid9emx 110 16 the the DT cord-000580-dcid9emx 110 17 most most RBS cord-000580-dcid9emx 110 18 widespread widespread JJ cord-000580-dcid9emx 110 19 family family NN cord-000580-dcid9emx 110 20 as as IN cord-000580-dcid9emx 110 21 the the DT cord-000580-dcid9emx 110 22 BLAST blast NN cord-000580-dcid9emx 110 23 classification classification NN cord-000580-dcid9emx 110 24 suggest suggest VBP cord-000580-dcid9emx 110 25 that that IN cord-000580-dcid9emx 110 26 it -PRON- PRP cord-000580-dcid9emx 110 27 is be VBZ cord-000580-dcid9emx 110 28 present present JJ cord-000580-dcid9emx 110 29 in in IN cord-000580-dcid9emx 110 30 two two CD cord-000580-dcid9emx 110 31 invertebrate invertebrate JJ cord-000580-dcid9emx 110 32 species specie NNS cord-000580-dcid9emx 110 33 and and CC cord-000580-dcid9emx 110 34 E. E. NNP cord-000580-dcid9emx 110 35 siliculosus siliculosus NNP cord-000580-dcid9emx 110 36 . . . cord-000580-dcid9emx 111 1 In in IN cord-000580-dcid9emx 111 2 mouse mouse NN cord-000580-dcid9emx 111 3 , , , cord-000580-dcid9emx 111 4 the the DT cord-000580-dcid9emx 111 5 family family NN cord-000580-dcid9emx 111 6 members member NNS cord-000580-dcid9emx 111 7 are be VBP cord-000580-dcid9emx 111 8 expressed express VBN cord-000580-dcid9emx 111 9 predominantly predominantly RB cord-000580-dcid9emx 111 10 in in IN cord-000580-dcid9emx 111 11 brain brain NN cord-000580-dcid9emx 111 12 tissues tissue NNS cord-000580-dcid9emx 112 1 ( ( -LRB- cord-000580-dcid9emx 113 1 Dspc1 Dspc1 NNP cord-000580-dcid9emx 113 2 / / SYM cord-000580-dcid9emx 113 3 Tmem90a Tmem90a NNP cord-000580-dcid9emx 113 4 , , , cord-000580-dcid9emx 113 5 Dspc2 Dspc2 NNP cord-000580-dcid9emx 113 6 / / SYM cord-000580-dcid9emx 113 7 Tmem90b Tmem90b NNP cord-000580-dcid9emx 113 8 ) ) -RRB- cord-000580-dcid9emx 113 9 or or CC cord-000580-dcid9emx 113 10 ubiquitously ubiquitously RB cord-000580-dcid9emx 113 11 ( ( -LRB- cord-000580-dcid9emx 113 12 Dspc3/ Dspc3/ NNP cord-000580-dcid9emx 113 13 Tmem91 Tmem91 NNP cord-000580-dcid9emx 113 14 ) ) -RRB- cord-000580-dcid9emx 113 15 . . . cord-000580-dcid9emx 114 1 DSPC1 DSPC1 NNP cord-000580-dcid9emx 115 1 ( ( -LRB- cord-000580-dcid9emx 115 2 TMEM90A TMEM90A NNP cord-000580-dcid9emx 115 3 ) ) -RRB- cord-000580-dcid9emx 115 4 has have VBZ cord-000580-dcid9emx 115 5 been be VBN cord-000580-dcid9emx 115 6 proposed propose VBN cord-000580-dcid9emx 115 7 to to TO cord-000580-dcid9emx 115 8 have have VB cord-000580-dcid9emx 115 9 a a DT cord-000580-dcid9emx 115 10 role role NN cord-000580-dcid9emx 115 11 in in IN cord-000580-dcid9emx 115 12 striatial striatial JJ cord-000580-dcid9emx 115 13 functioning function VBG cord-000580-dcid9emx 115 14 and and CC cord-000580-dcid9emx 115 15 the the DT cord-000580-dcid9emx 115 16 pathophysiology pathophysiology NN cord-000580-dcid9emx 115 17 of of IN cord-000580-dcid9emx 115 18 Huntington Huntington NNP cord-000580-dcid9emx 115 19 's 's POS cord-000580-dcid9emx 115 20 disease disease NN cord-000580-dcid9emx 115 21 and and CC cord-000580-dcid9emx 115 22 is be VBZ cord-000580-dcid9emx 115 23 localized localize VBN cord-000580-dcid9emx 115 24 to to IN cord-000580-dcid9emx 115 25 the the DT cord-000580-dcid9emx 115 26 Golgi Golgi NNP cord-000580-dcid9emx 115 27 apparatus apparatus NN cord-000580-dcid9emx 115 28 [ [ -LRB- cord-000580-dcid9emx 115 29 16 16 CD cord-000580-dcid9emx 115 30 ] ] -RRB- cord-000580-dcid9emx 115 31 . . . cord-000580-dcid9emx 116 1 The the DT cord-000580-dcid9emx 116 2 DSPD DSPD NNP cord-000580-dcid9emx 116 3 family family NN cord-000580-dcid9emx 116 4 has have VBZ cord-000580-dcid9emx 116 5 been be VBN cord-000580-dcid9emx 116 6 lost lose VBN cord-000580-dcid9emx 116 7 at at IN cord-000580-dcid9emx 116 8 several several JJ cord-000580-dcid9emx 116 9 occasions occasion NNS cord-000580-dcid9emx 116 10 , , , cord-000580-dcid9emx 116 11 both both CC cord-000580-dcid9emx 116 12 in in IN cord-000580-dcid9emx 116 13 vertebrates vertebrate NNS cord-000580-dcid9emx 116 14 and and CC cord-000580-dcid9emx 116 15 invertebrates invertebrate NNS cord-000580-dcid9emx 116 16 ( ( -LRB- cord-000580-dcid9emx 116 17 Figure figure NN cord-000580-dcid9emx 116 18 2 2 CD cord-000580-dcid9emx 116 19 ) ) -RRB- cord-000580-dcid9emx 116 20 . . . cord-000580-dcid9emx 117 1 The the DT cord-000580-dcid9emx 117 2 mouse mouse NN cord-000580-dcid9emx 117 3 Dspd1 dspd1 NN cord-000580-dcid9emx 117 4 ( ( -LRB- cord-000580-dcid9emx 117 5 Prrt1 Prrt1 NNP cord-000580-dcid9emx 117 6 ) ) -RRB- cord-000580-dcid9emx 117 7 gene gene NN cord-000580-dcid9emx 117 8 is be VBZ cord-000580-dcid9emx 117 9 ubiquitously ubiquitously RB cord-000580-dcid9emx 117 10 expressed express VBN cord-000580-dcid9emx 117 11 with with IN cord-000580-dcid9emx 117 12 the the DT cord-000580-dcid9emx 117 13 highest high JJS cord-000580-dcid9emx 117 14 expression expression NN cord-000580-dcid9emx 117 15 in in IN cord-000580-dcid9emx 117 16 B b NN cord-000580-dcid9emx 117 17 - - HYPH cord-000580-dcid9emx 117 18 cells cell NNS cord-000580-dcid9emx 117 19 according accord VBG cord-000580-dcid9emx 117 20 to to IN cord-000580-dcid9emx 117 21 BioGPS BioGPS NNP cord-000580-dcid9emx 117 22 [ [ -LRB- cord-000580-dcid9emx 117 23 17 17 CD cord-000580-dcid9emx 117 24 ] ] -RRB- cord-000580-dcid9emx 117 25 . . . cord-000580-dcid9emx 118 1 However however RB cord-000580-dcid9emx 118 2 , , , cord-000580-dcid9emx 118 3 no no DT cord-000580-dcid9emx 118 4 previous previous JJ cord-000580-dcid9emx 118 5 studies study NNS cord-000580-dcid9emx 118 6 have have VBP cord-000580-dcid9emx 118 7 been be VBN cord-000580-dcid9emx 118 8 performed perform VBN cord-000580-dcid9emx 118 9 on on IN cord-000580-dcid9emx 118 10 the the DT cord-000580-dcid9emx 118 11 DSPD DSPD NNP cord-000580-dcid9emx 118 12 subfamily subfamily NN cord-000580-dcid9emx 118 13 . . . cord-000580-dcid9emx 119 1 The the DT cord-000580-dcid9emx 119 2 DSPB DSPB NNP cord-000580-dcid9emx 119 3 subfamily subfamily NN cord-000580-dcid9emx 119 4 is be VBZ cord-000580-dcid9emx 119 5 found find VBN cord-000580-dcid9emx 119 6 in in IN cord-000580-dcid9emx 119 7 tetrapoda tetrapoda NNS cord-000580-dcid9emx 119 8 and and CC cord-000580-dcid9emx 119 9 has have VBZ cord-000580-dcid9emx 119 10 three three CD cord-000580-dcid9emx 119 11 members member NNS cord-000580-dcid9emx 119 12 in in IN cord-000580-dcid9emx 119 13 human human NN cord-000580-dcid9emx 119 14 and and CC cord-000580-dcid9emx 119 15 mouse mouse NN cord-000580-dcid9emx 119 16 . . . cord-000580-dcid9emx 120 1 Mice mice NN cord-000580-dcid9emx 120 2 expression expression NN cord-000580-dcid9emx 120 3 profiles profile NNS cord-000580-dcid9emx 120 4 from from IN cord-000580-dcid9emx 120 5 BioGPS biogps NN cord-000580-dcid9emx 120 6 shows show NNS cord-000580-dcid9emx 120 7 that that IN cord-000580-dcid9emx 120 8 Dspb3 dspb3 XX cord-000580-dcid9emx 121 1 ( ( -LRB- cord-000580-dcid9emx 121 2 Prrt2 Prrt2 NNP cord-000580-dcid9emx 121 3 ) ) -RRB- cord-000580-dcid9emx 121 4 is be VBZ cord-000580-dcid9emx 121 5 exclusively exclusively RB cord-000580-dcid9emx 121 6 expressed express VBN cord-000580-dcid9emx 121 7 in in IN cord-000580-dcid9emx 121 8 brain brain NN cord-000580-dcid9emx 121 9 tissues tissue NNS cord-000580-dcid9emx 121 10 and and CC cord-000580-dcid9emx 121 11 that that IN cord-000580-dcid9emx 121 12 Dspb1 Dspb1 NNP cord-000580-dcid9emx 121 13 ( ( -LRB- cord-000580-dcid9emx 121 14 Tusc5 Tusc5 NNP cord-000580-dcid9emx 121 15 ) ) -RRB- cord-000580-dcid9emx 121 16 is be VBZ cord-000580-dcid9emx 121 17 expressed express VBN cord-000580-dcid9emx 121 18 in in IN cord-000580-dcid9emx 121 19 dorsal dorsal JJ cord-000580-dcid9emx 121 20 root root NN cord-000580-dcid9emx 121 21 ganglia ganglion NNS cord-000580-dcid9emx 121 22 and and CC cord-000580-dcid9emx 121 23 adipose adipose JJ cord-000580-dcid9emx 121 24 tissues tissue NNS cord-000580-dcid9emx 121 25 . . . cord-000580-dcid9emx 122 1 In in IN cord-000580-dcid9emx 122 2 agreement agreement NN cord-000580-dcid9emx 122 3 with with IN cord-000580-dcid9emx 122 4 this this DT cord-000580-dcid9emx 122 5 expression expression NN cord-000580-dcid9emx 122 6 data datum NNS cord-000580-dcid9emx 122 7 , , , cord-000580-dcid9emx 122 8 Dspb1 Dspb1 NNP cord-000580-dcid9emx 122 9 ( ( -LRB- cord-000580-dcid9emx 122 10 Tusc5 Tusc5 NNP cord-000580-dcid9emx 122 11 ) ) -RRB- cord-000580-dcid9emx 122 12 has have VBZ cord-000580-dcid9emx 122 13 been be VBN cord-000580-dcid9emx 122 14 suggested suggest VBN cord-000580-dcid9emx 122 15 to to TO cord-000580-dcid9emx 122 16 be be VB cord-000580-dcid9emx 122 17 involved involve VBN cord-000580-dcid9emx 122 18 in in IN cord-000580-dcid9emx 122 19 neural neural JJ cord-000580-dcid9emx 122 20 regulation regulation NN cord-000580-dcid9emx 122 21 of of IN cord-000580-dcid9emx 122 22 adipocyte adipocyte NN cord-000580-dcid9emx 122 23 differentiation differentiation NN cord-000580-dcid9emx 122 24 and and CC cord-000580-dcid9emx 122 25 is be VBZ cord-000580-dcid9emx 122 26 regulated regulate VBN cord-000580-dcid9emx 122 27 by by IN cord-000580-dcid9emx 122 28 PPARc PPARc NNS cord-000580-dcid9emx 122 29 [ [ -LRB- cord-000580-dcid9emx 122 30 18 18 CD cord-000580-dcid9emx 122 31 , , , cord-000580-dcid9emx 122 32 19 19 CD cord-000580-dcid9emx 122 33 ] ] -RRB- cord-000580-dcid9emx 122 34 . . . cord-000580-dcid9emx 123 1 The the DT cord-000580-dcid9emx 123 2 DSPA DSPA NNP cord-000580-dcid9emx 123 3 / / SYM cord-000580-dcid9emx 123 4 IFITM IFITM NNP cord-000580-dcid9emx 123 5 subfamily subfamily NN cord-000580-dcid9emx 123 6 is be VBZ cord-000580-dcid9emx 123 7 the the DT cord-000580-dcid9emx 123 8 most most RBS cord-000580-dcid9emx 123 9 numerous numerous JJ cord-000580-dcid9emx 123 10 and and CC cord-000580-dcid9emx 123 11 the the DT cord-000580-dcid9emx 123 12 mouse mouse NN cord-000580-dcid9emx 123 13 and and CC cord-000580-dcid9emx 123 14 human human JJ cord-000580-dcid9emx 123 15 genes gene NNS cord-000580-dcid9emx 123 16 are be VBP cord-000580-dcid9emx 123 17 all all DT cord-000580-dcid9emx 123 18 clustered cluster VBN cord-000580-dcid9emx 123 19 in in IN cord-000580-dcid9emx 123 20 a a DT cord-000580-dcid9emx 123 21 consecutive consecutive JJ cord-000580-dcid9emx 123 22 manner manner NN cord-000580-dcid9emx 123 23 on on IN cord-000580-dcid9emx 123 24 chromosome chromosome NN cord-000580-dcid9emx 123 25 six six CD cord-000580-dcid9emx 123 26 and and CC cord-000580-dcid9emx 123 27 eleven eleven CD cord-000580-dcid9emx 123 28 , , , cord-000580-dcid9emx 123 29 respectively respectively RB cord-000580-dcid9emx 123 30 . . . cord-000580-dcid9emx 124 1 These these DT cord-000580-dcid9emx 124 2 regions region NNS cord-000580-dcid9emx 124 3 share share VBP cord-000580-dcid9emx 124 4 a a DT cord-000580-dcid9emx 124 5 conserved conserve VBN cord-000580-dcid9emx 124 6 synteny synteny NN cord-000580-dcid9emx 124 7 ( ( -LRB- cord-000580-dcid9emx 124 8 http:// http:// NNP cord-000580-dcid9emx 124 9 cinteny.cchmc.org/ cinteny.cchmc.org/ NNP cord-000580-dcid9emx 124 10 ) ) -RRB- cord-000580-dcid9emx 124 11 and and CC cord-000580-dcid9emx 124 12 are be VBP cord-000580-dcid9emx 124 13 flanked flank VBN cord-000580-dcid9emx 124 14 by by IN cord-000580-dcid9emx 124 15 the the DT cord-000580-dcid9emx 124 16 ATHL1 ATHL1 NNP cord-000580-dcid9emx 124 17 and and CC cord-000580-dcid9emx 124 18 B4GALNT4 B4GALNT4 NNP cord-000580-dcid9emx 124 19 genes gene NNS cord-000580-dcid9emx 124 20 on on IN cord-000580-dcid9emx 124 21 each each DT cord-000580-dcid9emx 124 22 side side NN cord-000580-dcid9emx 124 23 , , , cord-000580-dcid9emx 124 24 which which WDT cord-000580-dcid9emx 124 25 is be VBZ cord-000580-dcid9emx 124 26 strong strong JJ cord-000580-dcid9emx 124 27 evidence evidence NN cord-000580-dcid9emx 124 28 for for IN cord-000580-dcid9emx 124 29 the the DT cord-000580-dcid9emx 124 30 genes gene NNS cord-000580-dcid9emx 124 31 to to TO cord-000580-dcid9emx 124 32 have have VB cord-000580-dcid9emx 124 33 their -PRON- PRP$ cord-000580-dcid9emx 124 34 origin origin NN cord-000580-dcid9emx 124 35 in in IN cord-000580-dcid9emx 124 36 common common JJ cord-000580-dcid9emx 124 37 evolutionary evolutionary JJ cord-000580-dcid9emx 124 38 gene gene NN cord-000580-dcid9emx 124 39 duplications duplication NNS cord-000580-dcid9emx 124 40 . . . cord-000580-dcid9emx 125 1 This this DT cord-000580-dcid9emx 125 2 is be VBZ cord-000580-dcid9emx 125 3 supported support VBN cord-000580-dcid9emx 125 4 by by IN cord-000580-dcid9emx 125 5 the the DT cord-000580-dcid9emx 125 6 phylogenetic phylogenetic JJ cord-000580-dcid9emx 125 7 analysis analysis NN cord-000580-dcid9emx 125 8 ( ( -LRB- cord-000580-dcid9emx 125 9 Figure figure NN cord-000580-dcid9emx 125 10 1 1 CD cord-000580-dcid9emx 125 11 ) ) -RRB- cord-000580-dcid9emx 125 12 for for IN cord-000580-dcid9emx 125 13 DSPA1 dspa1 NN cord-000580-dcid9emx 125 14 ( ( -LRB- cord-000580-dcid9emx 125 15 IFITM5 IFITM5 NNP cord-000580-dcid9emx 125 16 ) ) -RRB- cord-000580-dcid9emx 125 17 and and CC cord-000580-dcid9emx 125 18 DSPA3 dspa3 JJ cord-000580-dcid9emx 125 19 ( ( -LRB- cord-000580-dcid9emx 125 20 AC068580 ac068580 NN cord-000580-dcid9emx 125 21 ) ) -RRB- cord-000580-dcid9emx 125 22 , , , cord-000580-dcid9emx 125 23 which which WDT cord-000580-dcid9emx 125 24 have have VBP cord-000580-dcid9emx 125 25 orthologs ortholog NNS cord-000580-dcid9emx 125 26 in in IN cord-000580-dcid9emx 125 27 all all DT cord-000580-dcid9emx 125 28 tetrapoda tetrapoda NNS cord-000580-dcid9emx 125 29 . . . cord-000580-dcid9emx 126 1 However however RB cord-000580-dcid9emx 126 2 , , , cord-000580-dcid9emx 126 3 for for IN cord-000580-dcid9emx 126 4 the the DT cord-000580-dcid9emx 126 5 DSPA2 DSPA2 NNP cord-000580-dcid9emx 126 6 group group NN cord-000580-dcid9emx 126 7 ( ( -LRB- cord-000580-dcid9emx 126 8 DSPA2A DSPA2A NNP cord-000580-dcid9emx 126 9 - - HYPH cord-000580-dcid9emx 126 10 D D NNP cord-000580-dcid9emx 126 11 / / SYM cord-000580-dcid9emx 126 12 IFITM1 IFITM1 NNP cord-000580-dcid9emx 126 13 - - HYPH cord-000580-dcid9emx 126 14 3 3 CD cord-000580-dcid9emx 126 15 and and CC cord-000580-dcid9emx 126 16 AC068580 ac068580 NN cord-000580-dcid9emx 126 17 ) ) -RRB- cord-000580-dcid9emx 127 1 the the DT cord-000580-dcid9emx 127 2 phylogeny phylogeny NN cord-000580-dcid9emx 127 3 suggests suggest VBZ cord-000580-dcid9emx 127 4 that that IN cord-000580-dcid9emx 127 5 M. M. NNP cord-000580-dcid9emx 127 6 musculus musculus NN cord-000580-dcid9emx 127 7 and and CC cord-000580-dcid9emx 127 8 H. h. NN cord-000580-dcid9emx 127 9 sapiens sapiens NNP cord-000580-dcid9emx 127 10 have have VBP cord-000580-dcid9emx 127 11 undergone undergo VBN cord-000580-dcid9emx 127 12 independent independent JJ cord-000580-dcid9emx 127 13 expansions expansion NNS cord-000580-dcid9emx 127 14 of of IN cord-000580-dcid9emx 127 15 the the DT cord-000580-dcid9emx 127 16 group group NN cord-000580-dcid9emx 127 17 . . . cord-000580-dcid9emx 128 1 Rather rather RB cord-000580-dcid9emx 128 2 than than IN cord-000580-dcid9emx 128 3 being be VBG cord-000580-dcid9emx 128 4 created create VBN cord-000580-dcid9emx 128 5 by by IN cord-000580-dcid9emx 128 6 independent independent JJ cord-000580-dcid9emx 128 7 gene gene NN cord-000580-dcid9emx 128 8 duplications duplication NNS cord-000580-dcid9emx 128 9 in in IN cord-000580-dcid9emx 128 10 the the DT cord-000580-dcid9emx 128 11 two two CD cord-000580-dcid9emx 128 12 species specie NNS cord-000580-dcid9emx 128 13 , , , cord-000580-dcid9emx 128 14 it -PRON- PRP cord-000580-dcid9emx 128 15 is be VBZ cord-000580-dcid9emx 128 16 possible possible JJ cord-000580-dcid9emx 128 17 that that IN cord-000580-dcid9emx 128 18 these these DT cord-000580-dcid9emx 128 19 genes gene NNS cord-000580-dcid9emx 128 20 are be VBP cord-000580-dcid9emx 128 21 subject subject JJ cord-000580-dcid9emx 128 22 to to IN cord-000580-dcid9emx 128 23 concerted concerted JJ cord-000580-dcid9emx 128 24 evolution evolution NN cord-000580-dcid9emx 128 25 , , , cord-000580-dcid9emx 128 26 where where WRB cord-000580-dcid9emx 128 27 paralogous paralogous JJ cord-000580-dcid9emx 128 28 genes gene NNS cord-000580-dcid9emx 128 29 within within IN cord-000580-dcid9emx 128 30 a a DT cord-000580-dcid9emx 128 31 species specie NNS cord-000580-dcid9emx 128 32 are be VBP cord-000580-dcid9emx 128 33 more more RBR cord-000580-dcid9emx 128 34 conserved conserve VBN cord-000580-dcid9emx 128 35 towards towards IN cord-000580-dcid9emx 128 36 each each DT cord-000580-dcid9emx 128 37 other other JJ cord-000580-dcid9emx 128 38 than than IN cord-000580-dcid9emx 128 39 towards towards IN cord-000580-dcid9emx 128 40 orthologs ortholog NNS cord-000580-dcid9emx 128 41 in in IN cord-000580-dcid9emx 128 42 other other JJ cord-000580-dcid9emx 128 43 species specie NNS cord-000580-dcid9emx 128 44 . . . cord-000580-dcid9emx 129 1 This this DT cord-000580-dcid9emx 129 2 phenomenon phenomenon NN cord-000580-dcid9emx 129 3 is be VBZ cord-000580-dcid9emx 129 4 most most RBS cord-000580-dcid9emx 129 5 common common JJ cord-000580-dcid9emx 129 6 in in IN cord-000580-dcid9emx 129 7 tandemly tandemly NNP cord-000580-dcid9emx 129 8 repeated repeat VBN cord-000580-dcid9emx 129 9 genes gene NNS cord-000580-dcid9emx 129 10 , , , cord-000580-dcid9emx 129 11 such such JJ cord-000580-dcid9emx 129 12 as as IN cord-000580-dcid9emx 129 13 the the DT cord-000580-dcid9emx 129 14 DSPA2 DSPA2 NNP cord-000580-dcid9emx 129 15 group group NN cord-000580-dcid9emx 129 16 , , , cord-000580-dcid9emx 129 17 and and CC cord-000580-dcid9emx 129 18 is be VBZ cord-000580-dcid9emx 129 19 believed believe VBN cord-000580-dcid9emx 129 20 to to TO cord-000580-dcid9emx 129 21 primarily primarily RB cord-000580-dcid9emx 129 22 be be VB cord-000580-dcid9emx 129 23 the the DT cord-000580-dcid9emx 129 24 result result NN cord-000580-dcid9emx 129 25 of of IN cord-000580-dcid9emx 129 26 recombination recombination NN cord-000580-dcid9emx 129 27 mechanisms mechanism NNS cord-000580-dcid9emx 129 28 [ [ -LRB- cord-000580-dcid9emx 129 29 20 20 CD cord-000580-dcid9emx 129 30 ] ] -RRB- cord-000580-dcid9emx 129 31 . . . cord-000580-dcid9emx 130 1 Interestingly interestingly RB cord-000580-dcid9emx 130 2 , , , cord-000580-dcid9emx 130 3 also also RB cord-000580-dcid9emx 130 4 the the DT cord-000580-dcid9emx 130 5 Dspa4a Dspa4a NNP cord-000580-dcid9emx 130 6 - - HYPH cord-000580-dcid9emx 130 7 f f NNP cord-000580-dcid9emx 130 8 genes gene NNS cord-000580-dcid9emx 130 9 of of IN cord-000580-dcid9emx 130 10 X. X. NNP cord-000580-dcid9emx 130 11 tropicalis tropicalis NNP cord-000580-dcid9emx 130 12 seem seem VBP cord-000580-dcid9emx 130 13 to to TO cord-000580-dcid9emx 130 14 have have VB cord-000580-dcid9emx 130 15 undergone undergo VBN cord-000580-dcid9emx 130 16 and and CC cord-000580-dcid9emx 130 17 independent independent JJ cord-000580-dcid9emx 130 18 expansion expansion NN cord-000580-dcid9emx 130 19 . . . cord-000580-dcid9emx 131 1 However however RB cord-000580-dcid9emx 131 2 , , , cord-000580-dcid9emx 131 3 the the DT cord-000580-dcid9emx 131 4 phylogeny phylogeny NN cord-000580-dcid9emx 131 5 is be VBZ cord-000580-dcid9emx 131 6 not not RB cord-000580-dcid9emx 131 7 strong strong JJ cord-000580-dcid9emx 131 8 enough enough RB cord-000580-dcid9emx 131 9 to to TO cord-000580-dcid9emx 131 10 prove prove VB cord-000580-dcid9emx 131 11 that that IN cord-000580-dcid9emx 131 12 the the DT cord-000580-dcid9emx 131 13 Dspa4a Dspa4a NNP cord-000580-dcid9emx 131 14 - - HYPH cord-000580-dcid9emx 131 15 f f NNP cord-000580-dcid9emx 131 16 genes gene NNS cord-000580-dcid9emx 131 17 are be VBP cord-000580-dcid9emx 131 18 orthologous orthologous JJ cord-000580-dcid9emx 131 19 to to IN cord-000580-dcid9emx 131 20 the the DT cord-000580-dcid9emx 131 21 mammalian mammalian JJ cord-000580-dcid9emx 131 22 DSPA2 DSPA2 NNP cord-000580-dcid9emx 131 23 genes gene NNS cord-000580-dcid9emx 131 24 ( ( -LRB- cord-000580-dcid9emx 131 25 Figure figure NN cord-000580-dcid9emx 131 26 1 1 CD cord-000580-dcid9emx 131 27 ) ) -RRB- cord-000580-dcid9emx 131 28 . . . cord-000580-dcid9emx 132 1 The the DT cord-000580-dcid9emx 132 2 DSPA DSPA NNP cord-000580-dcid9emx 132 3 / / SYM cord-000580-dcid9emx 132 4 IFITM IFITM NNP cord-000580-dcid9emx 132 5 subfamily subfamily NN cord-000580-dcid9emx 132 6 is be VBZ cord-000580-dcid9emx 132 7 the the DT cord-000580-dcid9emx 132 8 most most RBS cord-000580-dcid9emx 132 9 well well RB cord-000580-dcid9emx 132 10 studied study VBN cord-000580-dcid9emx 132 11 and and CC cord-000580-dcid9emx 132 12 is be VBZ cord-000580-dcid9emx 132 13 a a DT cord-000580-dcid9emx 132 14 multifunctional multifunctional JJ cord-000580-dcid9emx 132 15 family family NN cord-000580-dcid9emx 132 16 of of IN cord-000580-dcid9emx 132 17 which which WDT cord-000580-dcid9emx 132 18 its -PRON- PRP$ cord-000580-dcid9emx 132 19 antiviral antiviral JJ cord-000580-dcid9emx 132 20 properties property NNS cord-000580-dcid9emx 132 21 are be VBP cord-000580-dcid9emx 132 22 best best RB cord-000580-dcid9emx 132 23 understood understand VBN cord-000580-dcid9emx 132 24 [ [ -LRB- cord-000580-dcid9emx 132 25 8 8 CD cord-000580-dcid9emx 132 26 ] ] -RRB- cord-000580-dcid9emx 132 27 . . . cord-000580-dcid9emx 133 1 The the DT cord-000580-dcid9emx 133 2 family family NN cord-000580-dcid9emx 133 3 is be VBZ cord-000580-dcid9emx 133 4 expressed express VBN cord-000580-dcid9emx 133 5 in in IN cord-000580-dcid9emx 133 6 many many JJ cord-000580-dcid9emx 133 7 mouse mouse NN cord-000580-dcid9emx 133 8 tissues tissue NNS cord-000580-dcid9emx 133 9 with with IN cord-000580-dcid9emx 133 10 the the DT cord-000580-dcid9emx 133 11 highest high JJS cord-000580-dcid9emx 133 12 expression expression NN cord-000580-dcid9emx 133 13 in in IN cord-000580-dcid9emx 133 14 mast mast NN cord-000580-dcid9emx 133 15 cells cell NNS cord-000580-dcid9emx 133 16 , , , cord-000580-dcid9emx 133 17 macrophages macrophage NNS cord-000580-dcid9emx 133 18 and and CC cord-000580-dcid9emx 133 19 osteoblasts osteoblast NNS cord-000580-dcid9emx 133 20 according accord VBG cord-000580-dcid9emx 133 21 to to IN cord-000580-dcid9emx 133 22 BioGPS BioGPS NNP cord-000580-dcid9emx 133 23 . . . cord-000580-dcid9emx 134 1 We -PRON- PRP cord-000580-dcid9emx 134 2 add add VBP cord-000580-dcid9emx 134 3 two two CD cord-000580-dcid9emx 134 4 novel novel JJ cord-000580-dcid9emx 134 5 human human JJ cord-000580-dcid9emx 134 6 members member NNS cord-000580-dcid9emx 134 7 to to IN cord-000580-dcid9emx 134 8 this this DT cord-000580-dcid9emx 134 9 subfamily subfamily NN cord-000580-dcid9emx 134 10 : : : cord-000580-dcid9emx 134 11 DSPA2D DSPA2D NNP cord-000580-dcid9emx 134 12 , , , cord-000580-dcid9emx 134 13 which which WDT cord-000580-dcid9emx 134 14 is be VBZ cord-000580-dcid9emx 134 15 closely closely RB cord-000580-dcid9emx 134 16 related related JJ cord-000580-dcid9emx 134 17 to to IN cord-000580-dcid9emx 134 18 DSPA2C DSPA2C NNP cord-000580-dcid9emx 134 19 ( ( -LRB- cord-000580-dcid9emx 134 20 IFITM3 IFITM3 NNP cord-000580-dcid9emx 134 21 ) ) -RRB- cord-000580-dcid9emx 135 1 and and CC cord-000580-dcid9emx 135 2 DSPA3 DSPA3 NNP cord-000580-dcid9emx 135 3 , , , cord-000580-dcid9emx 135 4 which which WDT cord-000580-dcid9emx 135 5 forms form VBZ cord-000580-dcid9emx 135 6 a a DT cord-000580-dcid9emx 135 7 distinct distinct JJ cord-000580-dcid9emx 135 8 cluster cluster NN cord-000580-dcid9emx 135 9 ( ( -LRB- cord-000580-dcid9emx 135 10 Figure figure NN cord-000580-dcid9emx 135 11 1 1 CD cord-000580-dcid9emx 135 12 ) ) -RRB- cord-000580-dcid9emx 135 13 . . . cord-000580-dcid9emx 136 1 Both both CC cord-000580-dcid9emx 136 2 these these DT cord-000580-dcid9emx 136 3 genes gene NNS cord-000580-dcid9emx 136 4 are be VBP cord-000580-dcid9emx 136 5 poorly poorly RB cord-000580-dcid9emx 136 6 characterized characterize VBN cord-000580-dcid9emx 136 7 . . . cord-000580-dcid9emx 137 1 Microarray Microarray NNP cord-000580-dcid9emx 137 2 data datum NNS cord-000580-dcid9emx 137 3 from from IN cord-000580-dcid9emx 137 4 Array Array NNP cord-000580-dcid9emx 137 5 Express Express NNP cord-000580-dcid9emx 137 6 ( ( -LRB- cord-000580-dcid9emx 137 7 www.ebi.ac.uk/ www.ebi.ac.uk/ NNP cord-000580-dcid9emx 137 8 arrayexpress/ arrayexpress/ CD cord-000580-dcid9emx 137 9 ) ) -RRB- cord-000580-dcid9emx 137 10 shows show VBZ cord-000580-dcid9emx 137 11 that that IN cord-000580-dcid9emx 137 12 DSPA3 dspa3 NN cord-000580-dcid9emx 137 13 is be VBZ cord-000580-dcid9emx 137 14 upregulated upregulate VBN cord-000580-dcid9emx 137 15 by by IN cord-000580-dcid9emx 137 16 interferon interferon NN cord-000580-dcid9emx 137 17 after after IN cord-000580-dcid9emx 137 18 exposure exposure NN cord-000580-dcid9emx 137 19 of of IN cord-000580-dcid9emx 137 20 macrophages macrophage NNS cord-000580-dcid9emx 137 21 to to IN cord-000580-dcid9emx 137 22 interferon interferon NN cord-000580-dcid9emx 137 23 - - HYPH cord-000580-dcid9emx 137 24 gamma gamma NN cord-000580-dcid9emx 137 25 in in IN cord-000580-dcid9emx 137 26 a a DT cord-000580-dcid9emx 137 27 study study NN cord-000580-dcid9emx 138 1 ( ( -LRB- cord-000580-dcid9emx 138 2 E E NNP cord-000580-dcid9emx 138 3 - - HYPH cord-000580-dcid9emx 138 4 GEOD-5099 GEOD-5099 NNP cord-000580-dcid9emx 138 5 ) ) -RRB- cord-000580-dcid9emx 138 6 where where WRB cord-000580-dcid9emx 138 7 DSPA2a dspa2a NN cord-000580-dcid9emx 138 8 - - HYPH cord-000580-dcid9emx 138 9 c c NNP cord-000580-dcid9emx 138 10 ( ( -LRB- cord-000580-dcid9emx 138 11 IFITM1 IFITM1 NNP cord-000580-dcid9emx 138 12 - - HYPH cord-000580-dcid9emx 138 13 3 3 CD cord-000580-dcid9emx 138 14 ) ) -RRB- cord-000580-dcid9emx 138 15 also also RB cord-000580-dcid9emx 138 16 were be VBD cord-000580-dcid9emx 138 17 induced induce VBN cord-000580-dcid9emx 138 18 [ [ -LRB- cord-000580-dcid9emx 138 19 21 21 CD cord-000580-dcid9emx 138 20 ] ] -RRB- cord-000580-dcid9emx 138 21 . . . cord-000580-dcid9emx 139 1 The the DT cord-000580-dcid9emx 139 2 mouse mouse NN cord-000580-dcid9emx 139 3 Dspa3 Dspa3 VBZ cord-000580-dcid9emx 139 4 gene gene NN cord-000580-dcid9emx 139 5 is be VBZ cord-000580-dcid9emx 139 6 like like IN cord-000580-dcid9emx 139 7 the the DT cord-000580-dcid9emx 139 8 other other JJ cord-000580-dcid9emx 139 9 genes gene NNS cord-000580-dcid9emx 139 10 of of IN cord-000580-dcid9emx 139 11 this this DT cord-000580-dcid9emx 139 12 subfamily subfamily NN cord-000580-dcid9emx 139 13 situated situate VBN cord-000580-dcid9emx 139 14 on on IN cord-000580-dcid9emx 139 15 chromosome chromosome NN cord-000580-dcid9emx 139 16 seven seven CD cord-000580-dcid9emx 139 17 , , , cord-000580-dcid9emx 139 18 but but CC cord-000580-dcid9emx 139 19 is be VBZ cord-000580-dcid9emx 139 20 1.5 1.5 CD cord-000580-dcid9emx 139 21 Mbp Mbp NNP cord-000580-dcid9emx 139 22 away away RB cord-000580-dcid9emx 139 23 from from IN cord-000580-dcid9emx 139 24 the the DT cord-000580-dcid9emx 139 25 DSPA DSPA NNP cord-000580-dcid9emx 139 26 ( ( -LRB- cord-000580-dcid9emx 139 27 IFITM IFITM NNP cord-000580-dcid9emx 139 28 ) ) -RRB- cord-000580-dcid9emx 139 29 cluster cluster NN cord-000580-dcid9emx 139 30 where where WRB cord-000580-dcid9emx 139 31 the the DT cord-000580-dcid9emx 139 32 other other JJ cord-000580-dcid9emx 139 33 genes gene NNS cord-000580-dcid9emx 139 34 reside reside VBP cord-000580-dcid9emx 139 35 . . . cord-000580-dcid9emx 140 1 Hence hence RB cord-000580-dcid9emx 140 2 , , , cord-000580-dcid9emx 140 3 Dspa3 Dspa3 NNS cord-000580-dcid9emx 140 4 could could MD cord-000580-dcid9emx 140 5 explain explain VB cord-000580-dcid9emx 140 6 the the DT cord-000580-dcid9emx 140 7 mild mild JJ cord-000580-dcid9emx 140 8 phenotypes phenotype NNS cord-000580-dcid9emx 140 9 and and CC cord-000580-dcid9emx 140 10 be be VB cord-000580-dcid9emx 140 11 responsible responsible JJ cord-000580-dcid9emx 140 12 for for IN cord-000580-dcid9emx 140 13 the the DT cord-000580-dcid9emx 140 14 suggested suggest VBN cord-000580-dcid9emx 140 15 functional functional JJ cord-000580-dcid9emx 140 16 redundancy redundancy NN cord-000580-dcid9emx 140 17 that that WDT cord-000580-dcid9emx 140 18 was be VBD cord-000580-dcid9emx 140 19 found find VBN cord-000580-dcid9emx 140 20 when when WRB cord-000580-dcid9emx 140 21 deleting delete VBG cord-000580-dcid9emx 140 22 the the DT cord-000580-dcid9emx 140 23 whole whole JJ cord-000580-dcid9emx 140 24 DSPA DSPA NNP cord-000580-dcid9emx 140 25 ( ( -LRB- cord-000580-dcid9emx 140 26 IFITM IFITM NNP cord-000580-dcid9emx 140 27 ) ) -RRB- cord-000580-dcid9emx 140 28 loci locus NNS cord-000580-dcid9emx 140 29 [ [ -LRB- cord-000580-dcid9emx 140 30 22 22 CD cord-000580-dcid9emx 140 31 ] ] -RRB- cord-000580-dcid9emx 140 32 . . . cord-000580-dcid9emx 141 1 The the DT cord-000580-dcid9emx 141 2 Dispanin Dispanin NNP cord-000580-dcid9emx 141 3 family family NN cord-000580-dcid9emx 141 4 has have VBZ cord-000580-dcid9emx 141 5 several several JJ cord-000580-dcid9emx 141 6 conserved conserve VBN cord-000580-dcid9emx 141 7 motifs motif NNS cord-000580-dcid9emx 141 8 across across IN cord-000580-dcid9emx 141 9 subfamilies subfamily NNS cord-000580-dcid9emx 141 10 that that WDT cord-000580-dcid9emx 141 11 are be VBP cord-000580-dcid9emx 141 12 also also RB cord-000580-dcid9emx 141 13 detected detect VBN cord-000580-dcid9emx 141 14 in in IN cord-000580-dcid9emx 141 15 bacteria bacteria NNS cord-000580-dcid9emx 141 16 ( ( -LRB- cord-000580-dcid9emx 141 17 Figure figure NN cord-000580-dcid9emx 141 18 4 4 CD cord-000580-dcid9emx 141 19 ) ) -RRB- cord-000580-dcid9emx 141 20 . . . cord-000580-dcid9emx 142 1 One one CD cord-000580-dcid9emx 142 2 of of IN cord-000580-dcid9emx 142 3 the the DT cord-000580-dcid9emx 142 4 most most RBS cord-000580-dcid9emx 142 5 prominent prominent JJ cord-000580-dcid9emx 142 6 is be VBZ cord-000580-dcid9emx 142 7 the the DT cord-000580-dcid9emx 142 8 double double JJ cord-000580-dcid9emx 142 9 cysteine cysteine NN cord-000580-dcid9emx 142 10 motif motif NN cord-000580-dcid9emx 142 11 ( ( -LRB- cord-000580-dcid9emx 142 12 C c NN cord-000580-dcid9emx 142 13 - - HYPH cord-000580-dcid9emx 142 14 C C NNP cord-000580-dcid9emx 142 15 ) ) -RRB- cord-000580-dcid9emx 142 16 in in IN cord-000580-dcid9emx 142 17 the the DT cord-000580-dcid9emx 142 18 first first JJ cord-000580-dcid9emx 142 19 transmembrane transmembrane NN cord-000580-dcid9emx 142 20 helix helix NN cord-000580-dcid9emx 142 21 . . . cord-000580-dcid9emx 143 1 This this DT cord-000580-dcid9emx 143 2 motif motif NN cord-000580-dcid9emx 143 3 has have VBZ cord-000580-dcid9emx 143 4 recently recently RB cord-000580-dcid9emx 143 5 been be VBN cord-000580-dcid9emx 143 6 shown show VBN cord-000580-dcid9emx 143 7 to to TO cord-000580-dcid9emx 143 8 undergo undergo VB cord-000580-dcid9emx 143 9 post post JJ cord-000580-dcid9emx 143 10 - - JJ cord-000580-dcid9emx 143 11 translational translational JJ cord-000580-dcid9emx 143 12 modification modification NN cord-000580-dcid9emx 143 13 through through IN cord-000580-dcid9emx 143 14 S s NN cord-000580-dcid9emx 143 15 - - HYPH cord-000580-dcid9emx 143 16 palmitoylation palmitoylation NN cord-000580-dcid9emx 143 17 in in IN cord-000580-dcid9emx 143 18 DSPA2C DSPA2C NNP cord-000580-dcid9emx 143 19 ( ( -LRB- cord-000580-dcid9emx 143 20 IFITM3 IFITM3 NNP cord-000580-dcid9emx 143 21 ) ) -RRB- cord-000580-dcid9emx 143 22 , , , cord-000580-dcid9emx 143 23 which which WDT cord-000580-dcid9emx 143 24 increases increase VBZ cord-000580-dcid9emx 143 25 hydrophobicity hydrophobicity NN cord-000580-dcid9emx 143 26 [ [ -LRB- cord-000580-dcid9emx 143 27 23 23 CD cord-000580-dcid9emx 143 28 ] ] -RRB- cord-000580-dcid9emx 143 29 . . . cord-000580-dcid9emx 144 1 Further further RB cord-000580-dcid9emx 144 2 , , , cord-000580-dcid9emx 144 3 Yount Yount NNP cord-000580-dcid9emx 144 4 and and CC cord-000580-dcid9emx 144 5 colleagues colleague NNS cord-000580-dcid9emx 144 6 shows show VBZ cord-000580-dcid9emx 144 7 that that IN cord-000580-dcid9emx 144 8 the the DT cord-000580-dcid9emx 144 9 antiviral antiviral JJ cord-000580-dcid9emx 144 10 activity activity NN cord-000580-dcid9emx 144 11 of of IN cord-000580-dcid9emx 144 12 DSPA2C DSPA2C NNP cord-000580-dcid9emx 144 13 ( ( -LRB- cord-000580-dcid9emx 144 14 IFITM3 IFITM3 NNP cord-000580-dcid9emx 144 15 ) ) -RRB- cord-000580-dcid9emx 144 16 is be VBZ cord-000580-dcid9emx 144 17 dependent dependent JJ cord-000580-dcid9emx 144 18 on on IN cord-000580-dcid9emx 144 19 this this DT cord-000580-dcid9emx 144 20 modification modification NN cord-000580-dcid9emx 144 21 , , , cord-000580-dcid9emx 144 22 which which WDT cord-000580-dcid9emx 144 23 induces induce VBZ cord-000580-dcid9emx 144 24 clustering clustering NN cord-000580-dcid9emx 144 25 of of IN cord-000580-dcid9emx 144 26 the the DT cord-000580-dcid9emx 144 27 proteins protein NNS cord-000580-dcid9emx 144 28 . . . cord-000580-dcid9emx 145 1 As as IN cord-000580-dcid9emx 145 2 this this DT cord-000580-dcid9emx 145 3 motif motif NN cord-000580-dcid9emx 145 4 is be VBZ cord-000580-dcid9emx 145 5 highly highly RB cord-000580-dcid9emx 145 6 conserved conserve VBN cord-000580-dcid9emx 145 7 , , , cord-000580-dcid9emx 145 8 it -PRON- PRP cord-000580-dcid9emx 145 9 is be VBZ cord-000580-dcid9emx 145 10 likely likely JJ cord-000580-dcid9emx 145 11 that that IN cord-000580-dcid9emx 145 12 S s NN cord-000580-dcid9emx 145 13 - - HYPH cord-000580-dcid9emx 145 14 palmitoylation palmitoylation NNP cord-000580-dcid9emx 145 15 is be VBZ cord-000580-dcid9emx 145 16 an an DT cord-000580-dcid9emx 145 17 important important JJ cord-000580-dcid9emx 145 18 regulatory regulatory JJ cord-000580-dcid9emx 145 19 mechanism mechanism NN cord-000580-dcid9emx 145 20 also also RB cord-000580-dcid9emx 145 21 among among IN cord-000580-dcid9emx 145 22 the the DT cord-000580-dcid9emx 145 23 other other JJ cord-000580-dcid9emx 145 24 subfamilies subfamily NNS cord-000580-dcid9emx 145 25 . . . cord-000580-dcid9emx 146 1 Intriguingly intriguingly RB cord-000580-dcid9emx 146 2 , , , cord-000580-dcid9emx 146 3 this this DT cord-000580-dcid9emx 146 4 motif motif NN cord-000580-dcid9emx 146 5 is be VBZ cord-000580-dcid9emx 146 6 also also RB cord-000580-dcid9emx 146 7 found find VBN cord-000580-dcid9emx 146 8 in in IN cord-000580-dcid9emx 146 9 the the DT cord-000580-dcid9emx 146 10 bacterial bacterial JJ cord-000580-dcid9emx 146 11 Dispanins Dispanins NNPS cord-000580-dcid9emx 146 12 even even RB cord-000580-dcid9emx 146 13 though though IN cord-000580-dcid9emx 146 14 bacterial bacterial JJ cord-000580-dcid9emx 146 15 proteins protein NNS cord-000580-dcid9emx 146 16 do do VBP cord-000580-dcid9emx 146 17 not not RB cord-000580-dcid9emx 146 18 undergo undergo VB cord-000580-dcid9emx 146 19 S S NNP cord-000580-dcid9emx 146 20 - - HYPH cord-000580-dcid9emx 146 21 palmitoylation palmitoylation NN cord-000580-dcid9emx 146 22 . . . cord-000580-dcid9emx 147 1 Hence hence RB cord-000580-dcid9emx 147 2 , , , cord-000580-dcid9emx 147 3 the the DT cord-000580-dcid9emx 147 4 cysteine cysteine NN cord-000580-dcid9emx 147 5 motif motif NN cord-000580-dcid9emx 147 6 of of IN cord-000580-dcid9emx 147 7 the the DT cord-000580-dcid9emx 147 8 may may MD cord-000580-dcid9emx 147 9 have have VB cord-000580-dcid9emx 147 10 other other JJ cord-000580-dcid9emx 147 11 means mean NNS cord-000580-dcid9emx 147 12 of of IN cord-000580-dcid9emx 147 13 structural structural JJ cord-000580-dcid9emx 147 14 and and CC cord-000580-dcid9emx 147 15 functional functional JJ cord-000580-dcid9emx 147 16 importance importance NN cord-000580-dcid9emx 147 17 apart apart RB cord-000580-dcid9emx 147 18 of of IN cord-000580-dcid9emx 147 19 from from IN cord-000580-dcid9emx 147 20 the the DT cord-000580-dcid9emx 147 21 S S NNP cord-000580-dcid9emx 147 22 - - HYPH cord-000580-dcid9emx 147 23 palmitoylation palmitoylation NN cord-000580-dcid9emx 147 24 . . . cord-000580-dcid9emx 148 1 In in IN cord-000580-dcid9emx 148 2 this this DT cord-000580-dcid9emx 148 3 study study NN cord-000580-dcid9emx 148 4 , , , cord-000580-dcid9emx 148 5 we -PRON- PRP cord-000580-dcid9emx 148 6 introduce introduce VBP cord-000580-dcid9emx 148 7 the the DT cord-000580-dcid9emx 148 8 Dispanin Dispanin NNP cord-000580-dcid9emx 148 9 family family NN cord-000580-dcid9emx 148 10 , , , cord-000580-dcid9emx 148 11 of of IN cord-000580-dcid9emx 148 12 which which WDT cord-000580-dcid9emx 148 13 the the DT cord-000580-dcid9emx 148 14 IFITM IFITM NNP cord-000580-dcid9emx 148 15 genes gene NNS cord-000580-dcid9emx 148 16 constitute constitute VBP cord-000580-dcid9emx 148 17 a a DT cord-000580-dcid9emx 148 18 subfamily subfamily NN cord-000580-dcid9emx 148 19 . . . cord-000580-dcid9emx 149 1 In in IN cord-000580-dcid9emx 149 2 addition addition NN cord-000580-dcid9emx 149 3 to to IN cord-000580-dcid9emx 149 4 the the DT cord-000580-dcid9emx 149 5 IFITM IFITM NNP cord-000580-dcid9emx 149 6 genes gene NNS cord-000580-dcid9emx 149 7 we -PRON- PRP cord-000580-dcid9emx 149 8 identify identify VBP cord-000580-dcid9emx 149 9 10 10 CD cord-000580-dcid9emx 149 10 novel novel JJ cord-000580-dcid9emx 149 11 human human JJ cord-000580-dcid9emx 149 12 Dispanins Dispanins NNPS cord-000580-dcid9emx 149 13 and and CC cord-000580-dcid9emx 149 14 investigate investigate VB cord-000580-dcid9emx 149 15 the the DT cord-000580-dcid9emx 149 16 family family NN cord-000580-dcid9emx 149 17 's 's POS cord-000580-dcid9emx 149 18 evolutionary evolutionary JJ cord-000580-dcid9emx 149 19 history history NN cord-000580-dcid9emx 149 20 and and CC cord-000580-dcid9emx 149 21 suggest suggest VBP cord-000580-dcid9emx 149 22 that that IN cord-000580-dcid9emx 149 23 the the DT cord-000580-dcid9emx 149 24 eukaryotic eukaryotic JJ cord-000580-dcid9emx 149 25 members member NNS cord-000580-dcid9emx 149 26 are be VBP cord-000580-dcid9emx 149 27 descending descend VBG cord-000580-dcid9emx 149 28 from from IN cord-000580-dcid9emx 149 29 bacteria bacteria NNS cord-000580-dcid9emx 149 30 through through IN cord-000580-dcid9emx 149 31 a a DT cord-000580-dcid9emx 149 32 horizontal horizontal JJ cord-000580-dcid9emx 149 33 gene gene NN cord-000580-dcid9emx 149 34 transfer transfer NN cord-000580-dcid9emx 149 35 . . . cord-000580-dcid9emx 150 1 Thus thus RB cord-000580-dcid9emx 150 2 , , , cord-000580-dcid9emx 150 3 the the DT cord-000580-dcid9emx 150 4 expansion expansion NN cord-000580-dcid9emx 150 5 and and CC cord-000580-dcid9emx 150 6 diversification diversification NN cord-000580-dcid9emx 150 7 of of IN cord-000580-dcid9emx 150 8 Dispanins Dispanins NNP cord-000580-dcid9emx 150 9 in in IN cord-000580-dcid9emx 150 10 vertebrates vertebrate NNS cord-000580-dcid9emx 150 11 may may MD cord-000580-dcid9emx 150 12 reflect reflect VB cord-000580-dcid9emx 150 13 the the DT cord-000580-dcid9emx 150 14 evolution evolution NN cord-000580-dcid9emx 150 15 of of IN cord-000580-dcid9emx 150 16 a a DT cord-000580-dcid9emx 150 17 larger large JJR cord-000580-dcid9emx 150 18 functional functional JJ cord-000580-dcid9emx 150 19 repertoire repertoire NN cord-000580-dcid9emx 150 20 , , , cord-000580-dcid9emx 150 21 which which WDT cord-000580-dcid9emx 150 22 is be VBZ cord-000580-dcid9emx 150 23 a a DT cord-000580-dcid9emx 150 24 supported support VBN cord-000580-dcid9emx 150 25 by by IN cord-000580-dcid9emx 150 26 the the DT cord-000580-dcid9emx 150 27 distinct distinct JJ cord-000580-dcid9emx 150 28 expression expression NN cord-000580-dcid9emx 150 29 profiles profile NNS cord-000580-dcid9emx 150 30 Figure Figure NNP cord-000580-dcid9emx 150 31 3 3 CD cord-000580-dcid9emx 150 32 . . . cord-000580-dcid9emx 151 1 The the DT cord-000580-dcid9emx 151 2 protein protein NN cord-000580-dcid9emx 151 3 features feature VBZ cord-000580-dcid9emx 151 4 and and CC cord-000580-dcid9emx 151 5 topology topology NN cord-000580-dcid9emx 151 6 of of IN cord-000580-dcid9emx 151 7 the the DT cord-000580-dcid9emx 151 8 Dispanin Dispanin NNP cord-000580-dcid9emx 151 9 subfamilies subfamily NNS cord-000580-dcid9emx 151 10 . . . cord-000580-dcid9emx 152 1 The the DT cord-000580-dcid9emx 152 2 picture picture NN cord-000580-dcid9emx 152 3 shows show VBZ cord-000580-dcid9emx 152 4 the the DT cord-000580-dcid9emx 152 5 membrane membrane NN cord-000580-dcid9emx 152 6 topology topology NN cord-000580-dcid9emx 152 7 and and CC cord-000580-dcid9emx 152 8 sequences sequence NNS cord-000580-dcid9emx 152 9 features feature NNS cord-000580-dcid9emx 152 10 of of IN cord-000580-dcid9emx 152 11 a a DT cord-000580-dcid9emx 152 12 representative representative JJ cord-000580-dcid9emx 152 13 human human JJ cord-000580-dcid9emx 152 14 member member NN cord-000580-dcid9emx 152 15 of of IN cord-000580-dcid9emx 152 16 each each DT cord-000580-dcid9emx 152 17 subfamily subfamily NN cord-000580-dcid9emx 152 18 . . . cord-000580-dcid9emx 153 1 Conserved conserved JJ cord-000580-dcid9emx 153 2 motifs motif NNS cord-000580-dcid9emx 153 3 and and CC cord-000580-dcid9emx 153 4 residues residue NNS cord-000580-dcid9emx 153 5 are be VBP cord-000580-dcid9emx 153 6 shown show VBN cord-000580-dcid9emx 153 7 and and CC cord-000580-dcid9emx 153 8 those those DT cord-000580-dcid9emx 153 9 which which WDT cord-000580-dcid9emx 153 10 have have VBP cord-000580-dcid9emx 153 11 a a DT cord-000580-dcid9emx 153 12 sequence sequence NN cord-000580-dcid9emx 153 13 identity identity NN cord-000580-dcid9emx 153 14 of of IN cord-000580-dcid9emx 153 15 more more JJR cord-000580-dcid9emx 153 16 than than IN cord-000580-dcid9emx 153 17 90 90 CD cord-000580-dcid9emx 153 18 % % NN cord-000580-dcid9emx 153 19 are be VBP cord-000580-dcid9emx 153 20 framed frame VBN cord-000580-dcid9emx 153 21 in in IN cord-000580-dcid9emx 153 22 black black NN cord-000580-dcid9emx 153 23 and and CC cord-000580-dcid9emx 153 24 those those DT cord-000580-dcid9emx 153 25 with with IN cord-000580-dcid9emx 153 26 80 80 CD cord-000580-dcid9emx 153 27 - - SYM cord-000580-dcid9emx 153 28 90 90 CD cord-000580-dcid9emx 153 29 % % NN cord-000580-dcid9emx 153 30 sequence sequence NN cord-000580-dcid9emx 153 31 similarity similarity NN cord-000580-dcid9emx 153 32 are be VBP cord-000580-dcid9emx 153 33 framed frame VBN cord-000580-dcid9emx 153 34 in in IN cord-000580-dcid9emx 153 35 blue blue JJ cord-000580-dcid9emx 153 36 . . . cord-000580-dcid9emx 154 1 Predicted predict VBN cord-000580-dcid9emx 154 2 phosphorylation phosphorylation NN cord-000580-dcid9emx 154 3 ( ( -LRB- cord-000580-dcid9emx 154 4 Green Green NNP cord-000580-dcid9emx 154 5 ) ) -RRB- cord-000580-dcid9emx 154 6 and and CC cord-000580-dcid9emx 154 7 glycosylation glycosylation NN cord-000580-dcid9emx 154 8 ( ( -LRB- cord-000580-dcid9emx 154 9 orange orange NNP cord-000580-dcid9emx 154 10 ) ) -RRB- cord-000580-dcid9emx 154 11 sites site NNS cord-000580-dcid9emx 154 12 are be VBP cord-000580-dcid9emx 154 13 shown show VBN cord-000580-dcid9emx 154 14 . . . cord-000580-dcid9emx 155 1 doi:10.1371 doi:10.1371 NNP cord-000580-dcid9emx 155 2 / / SYM cord-000580-dcid9emx 155 3 journal.pone.0031961.g003 journal.pone.0031961.g003 NNP cord-000580-dcid9emx 155 4 of of IN cord-000580-dcid9emx 155 5 the the DT cord-000580-dcid9emx 155 6 subfamilies subfamily NNS cord-000580-dcid9emx 155 7 . . . cord-000580-dcid9emx 156 1 By by IN cord-000580-dcid9emx 156 2 identifying identify VBG cord-000580-dcid9emx 156 3 homologs homolog NNS cord-000580-dcid9emx 156 4 to to IN cord-000580-dcid9emx 156 5 the the DT cord-000580-dcid9emx 156 6 IFITM IFITM NNP cord-000580-dcid9emx 156 7 genes gene NNS cord-000580-dcid9emx 156 8 and and CC cord-000580-dcid9emx 156 9 establishing establish VBG cord-000580-dcid9emx 156 10 the the DT cord-000580-dcid9emx 156 11 Dispanins Dispanins NNPS cord-000580-dcid9emx 156 12 as as IN cord-000580-dcid9emx 156 13 a a DT cord-000580-dcid9emx 156 14 family family NN cord-000580-dcid9emx 156 15 together together RB cord-000580-dcid9emx 156 16 with with IN cord-000580-dcid9emx 156 17 a a DT cord-000580-dcid9emx 156 18 solid solid JJ cord-000580-dcid9emx 156 19 detailed detailed JJ cord-000580-dcid9emx 156 20 and and CC cord-000580-dcid9emx 156 21 evolutionary evolutionary JJ cord-000580-dcid9emx 156 22 based base VBN cord-000580-dcid9emx 156 23 nomenclature nomenclature NN cord-000580-dcid9emx 156 24 for for IN cord-000580-dcid9emx 156 25 the the DT cord-000580-dcid9emx 156 26 vertebrate vertebrate JJ cord-000580-dcid9emx 156 27 genes gene NNS cord-000580-dcid9emx 156 28 , , , cord-000580-dcid9emx 156 29 we -PRON- PRP cord-000580-dcid9emx 156 30 provide provide VBP cord-000580-dcid9emx 156 31 a a DT cord-000580-dcid9emx 156 32 fundament fundament NN cord-000580-dcid9emx 156 33 for for IN cord-000580-dcid9emx 156 34 future future JJ cord-000580-dcid9emx 156 35 functional functional JJ cord-000580-dcid9emx 156 36 characterization characterization NN cord-000580-dcid9emx 156 37 these these DT cord-000580-dcid9emx 156 38 genes gene NNS cord-000580-dcid9emx 156 39 . . . cord-000580-dcid9emx 157 1 The the DT cord-000580-dcid9emx 157 2 whole whole JJ cord-000580-dcid9emx 157 3 proteome proteome NN cord-000580-dcid9emx 157 4 dataset dataset NN cord-000580-dcid9emx 157 5 for for IN cord-000580-dcid9emx 157 6 the the DT cord-000580-dcid9emx 157 7 following follow VBG cord-000580-dcid9emx 157 8 eukaryotic eukaryotic JJ cord-000580-dcid9emx 157 9 species specie NNS cord-000580-dcid9emx 157 10 was be VBD cord-000580-dcid9emx 157 11 included include VBN cord-000580-dcid9emx 157 12 in in IN cord-000580-dcid9emx 157 13 the the DT cord-000580-dcid9emx 157 14 analysis analysis NN cord-000580-dcid9emx 157 15 : : : cord-000580-dcid9emx 158 1 Homo homo NN cord-000580-dcid9emx 158 2 sapiens sapiens JJ cord-000580-dcid9emx 158 3 , , , cord-000580-dcid9emx 158 4 Mus mus NN cord-000580-dcid9emx 158 5 musculus musculus NN cord-000580-dcid9emx 158 6 , , , cord-000580-dcid9emx 158 7 Gallus Gallus NNP cord-000580-dcid9emx 158 8 gallus gallus NN cord-000580-dcid9emx 158 9 , , , cord-000580-dcid9emx 158 10 Xenopus Xenopus NNP cord-000580-dcid9emx 158 11 tropicalis tropicalis NNP cord-000580-dcid9emx 158 12 , , , cord-000580-dcid9emx 158 13 Danio Danio NNP cord-000580-dcid9emx 158 14 rerio rerio NN cord-000580-dcid9emx 158 15 , , , cord-000580-dcid9emx 158 16 Petromyzon Petromyzon NNP cord-000580-dcid9emx 158 17 marinus marinus NN cord-000580-dcid9emx 158 18 , , , cord-000580-dcid9emx 158 19 Drosophila Drosophila NNP cord-000580-dcid9emx 158 20 melanogaster melanogaster NN cord-000580-dcid9emx 158 21 , , , cord-000580-dcid9emx 158 22 Caenorhabditis Caenorhabditis NNP cord-000580-dcid9emx 158 23 elegans elegan NNS cord-000580-dcid9emx 158 24 , , , cord-000580-dcid9emx 158 25 Saccharomyces Saccharomyces NNP cord-000580-dcid9emx 158 26 cerviciae cerviciae NNS cord-000580-dcid9emx 158 27 , , , cord-000580-dcid9emx 158 28 Schistosoma Schistosoma NNP cord-000580-dcid9emx 158 29 mansoni mansoni NNP cord-000580-dcid9emx 158 30 , , , cord-000580-dcid9emx 158 31 Apis Apis NNP cord-000580-dcid9emx 158 32 mellifera mellifera NN cord-000580-dcid9emx 158 33 , , , cord-000580-dcid9emx 158 34 Anopheles Anopheles NNP cord-000580-dcid9emx 158 35 gambiae gambiae NN cord-000580-dcid9emx 158 36 , , , cord-000580-dcid9emx 158 37 Pediculus Pediculus NNP cord-000580-dcid9emx 158 38 humanus humanus NN cord-000580-dcid9emx 158 39 , , , cord-000580-dcid9emx 158 40 Ixodes Ixodes NNP cord-000580-dcid9emx 158 41 scapularis scapularis NN cord-000580-dcid9emx 158 42 , , , cord-000580-dcid9emx 158 43 Daphnia daphnia NN cord-000580-dcid9emx 158 44 pulex pulex NN cord-000580-dcid9emx 158 45 , , , cord-000580-dcid9emx 158 46 Oryza oryza NN cord-000580-dcid9emx 158 47 sativa sativa NN cord-000580-dcid9emx 158 48 , , , cord-000580-dcid9emx 158 49 Pristionchus Pristionchus NNP cord-000580-dcid9emx 158 50 pacificus pacificus NN cord-000580-dcid9emx 158 51 , , , cord-000580-dcid9emx 158 52 Acyrthosiphon Acyrthosiphon NNP cord-000580-dcid9emx 158 53 pisum pisum NN cord-000580-dcid9emx 158 54 , , , cord-000580-dcid9emx 158 55 Trypanosoma Trypanosoma NNP cord-000580-dcid9emx 158 56 brucei brucei NNP cord-000580-dcid9emx 158 57 , , , cord-000580-dcid9emx 158 58 Leishmania Leishmania NNP cord-000580-dcid9emx 158 59 braziliensis braziliensis NN cord-000580-dcid9emx 158 60 and and CC cord-000580-dcid9emx 158 61 Ciona Ciona NNP cord-000580-dcid9emx 158 62 instestinalis instestinali NNS cord-000580-dcid9emx 158 63 were be VBD cord-000580-dcid9emx 158 64 downloaded download VBN cord-000580-dcid9emx 158 65 from from IN cord-000580-dcid9emx 158 66 Ensembl Ensembl NNP cord-000580-dcid9emx 158 67 ; ; : cord-000580-dcid9emx 158 68 Strongylocentrous Strongylocentrous NNP cord-000580-dcid9emx 158 69 purpuratus purpuratus NN cord-000580-dcid9emx 158 70 was be VBD cord-000580-dcid9emx 158 71 downloaded download VBN cord-000580-dcid9emx 158 72 from from IN cord-000580-dcid9emx 158 73 Spbase Spbase NNP cord-000580-dcid9emx 158 74 ( ( -LRB- cord-000580-dcid9emx 158 75 www.spabase.org www.spabase.org NN cord-000580-dcid9emx 158 76 ) ) -RRB- cord-000580-dcid9emx 158 77 ; ; : cord-000580-dcid9emx 158 78 Branchiostoma Branchiostoma NNP cord-000580-dcid9emx 158 79 floridae floridae NN cord-000580-dcid9emx 158 80 , , , cord-000580-dcid9emx 158 81 Nematostella Nematostella NNP cord-000580-dcid9emx 158 82 vectensis vectensis NN cord-000580-dcid9emx 158 83 , , , cord-000580-dcid9emx 158 84 Trichoplax Trichoplax NNP cord-000580-dcid9emx 158 85 adhaerens adhaeren NNS cord-000580-dcid9emx 158 86 , , , cord-000580-dcid9emx 158 87 Phytophtera Phytophtera NNP cord-000580-dcid9emx 158 88 soyae soyae NN cord-000580-dcid9emx 158 89 , , , cord-000580-dcid9emx 158 90 Thalassiosira Thalassiosira NNP cord-000580-dcid9emx 158 91 pseudonana pseudonana NNS cord-000580-dcid9emx 158 92 , , , cord-000580-dcid9emx 158 93 Naegleria Naegleria NNP cord-000580-dcid9emx 158 94 gruberi gruberi NN cord-000580-dcid9emx 158 95 and and CC cord-000580-dcid9emx 158 96 Monosiga Monosiga NNPS cord-000580-dcid9emx 158 97 brevicollis brevicollis NNP cord-000580-dcid9emx 158 98 were be VBD cord-000580-dcid9emx 158 99 downloaded download VBN cord-000580-dcid9emx 158 100 from from IN cord-000580-dcid9emx 158 101 the the DT cord-000580-dcid9emx 158 102 Joint Joint NNP cord-000580-dcid9emx 158 103 Genome Genome NNP cord-000580-dcid9emx 158 104 Institute Institute NNP cord-000580-dcid9emx 158 105 ; ; : cord-000580-dcid9emx 158 106 Dictyostelium Dictyostelium NNP cord-000580-dcid9emx 158 107 discoideum discoideum NNP cord-000580-dcid9emx 158 108 was be VBD cord-000580-dcid9emx 158 109 downloaded download VBN cord-000580-dcid9emx 158 110 from from IN cord-000580-dcid9emx 158 111 dictyBase dictyBase NNP cord-000580-dcid9emx 158 112 ( ( -LRB- cord-000580-dcid9emx 158 113 www.dictybase.org www.dictybase.org NN cord-000580-dcid9emx 158 114 ) ) -RRB- cord-000580-dcid9emx 158 115 ; ; : cord-000580-dcid9emx 158 116 Arabidopsis Arabidopsis NNP cord-000580-dcid9emx 158 117 thaliana thaliana NN cord-000580-dcid9emx 158 118 was be VBD cord-000580-dcid9emx 158 119 downloaded download VBN cord-000580-dcid9emx 158 120 from from IN cord-000580-dcid9emx 158 121 TAIR TAIR NNP cord-000580-dcid9emx 158 122 ( ( -LRB- cord-000580-dcid9emx 158 123 http://www.arabidopsis.org/ http://www.arabidopsis.org/ ADD cord-000580-dcid9emx 158 124 ) ) -RRB- cord-000580-dcid9emx 158 125 ; ; : cord-000580-dcid9emx 158 126 Entamoeba Entamoeba NNP cord-000580-dcid9emx 158 127 histolytica histolytica NNP cord-000580-dcid9emx 158 128 was be VBD cord-000580-dcid9emx 158 129 downloaded download VBN cord-000580-dcid9emx 158 130 from from IN cord-000580-dcid9emx 158 131 amoebaDB amoebaDB NNP cord-000580-dcid9emx 158 132 ( ( -LRB- cord-000580-dcid9emx 158 133 http://amoebadb.org http://amoebadb.org $ cord-000580-dcid9emx 158 134 ) ) -RRB- cord-000580-dcid9emx 158 135 ; ; : cord-000580-dcid9emx 158 136 Paramecium Paramecium NNP cord-000580-dcid9emx 158 137 tetraurelia tetraurelia NNP cord-000580-dcid9emx 158 138 was be VBD cord-000580-dcid9emx 158 139 downloaded download VBN cord-000580-dcid9emx 158 140 from from IN cord-000580-dcid9emx 158 141 NCBI NCBI NNP cord-000580-dcid9emx 158 142 ; ; : cord-000580-dcid9emx 158 143 Tetrahymena Tetrahymena NNP cord-000580-dcid9emx 158 144 thermophila thermophila NN cord-000580-dcid9emx 158 145 was be VBD cord-000580-dcid9emx 158 146 downloaded download VBN cord-000580-dcid9emx 158 147 from from IN cord-000580-dcid9emx 158 148 UniProt UniProt NNP cord-000580-dcid9emx 158 149 ; ; : cord-000580-dcid9emx 158 150 Trichomonas Trichomonas NNP cord-000580-dcid9emx 158 151 vaginalis vaginalis NN cord-000580-dcid9emx 158 152 was be VBD cord-000580-dcid9emx 158 153 downloaded download VBN cord-000580-dcid9emx 158 154 from from IN cord-000580-dcid9emx 158 155 TrichDB TrichDB NNP cord-000580-dcid9emx 158 156 ( ( -LRB- cord-000580-dcid9emx 158 157 http://trichdb.org http://trichdb.org NNP cord-000580-dcid9emx 158 158 ) ) -RRB- cord-000580-dcid9emx 158 159 ; ; : cord-000580-dcid9emx 158 160 Giardia Giardia NNP cord-000580-dcid9emx 158 161 lamblia lamblia NNP cord-000580-dcid9emx 158 162 was be VBD cord-000580-dcid9emx 158 163 downloaded download VBN cord-000580-dcid9emx 158 164 fromGiardiaDB fromGiardiaDB NNP cord-000580-dcid9emx 158 165 ( ( -LRB- cord-000580-dcid9emx 158 166 http://giardiadb.org http://giardiadb.org ADD cord-000580-dcid9emx 158 167 ) ) -RRB- cord-000580-dcid9emx 158 168 . . . cord-000580-dcid9emx 159 1 All all DT cord-000580-dcid9emx 159 2 proteomes proteome NNS cord-000580-dcid9emx 159 3 were be VBD cord-000580-dcid9emx 159 4 searched search VBN cord-000580-dcid9emx 159 5 against against IN cord-000580-dcid9emx 159 6 a a DT cord-000580-dcid9emx 159 7 local local JJ cord-000580-dcid9emx 159 8 installation installation NN cord-000580-dcid9emx 159 9 of of IN cord-000580-dcid9emx 159 10 the the DT cord-000580-dcid9emx 159 11 Pfam Pfam NNP cord-000580-dcid9emx 159 12 database database NN cord-000580-dcid9emx 159 13 ( ( -LRB- cord-000580-dcid9emx 159 14 v.23 v.23 NNP cord-000580-dcid9emx 159 15 ) ) -RRB- cord-000580-dcid9emx 159 16 [ [ -LRB- cord-000580-dcid9emx 159 17 24 24 CD cord-000580-dcid9emx 159 18 ] ] -RRB- cord-000580-dcid9emx 159 19 using use VBG cord-000580-dcid9emx 159 20 HMMER3 HMMER3 NNP cord-000580-dcid9emx 159 21 [ [ -LRB- cord-000580-dcid9emx 159 22 25 25 CD cord-000580-dcid9emx 159 23 ] ] -RRB- cord-000580-dcid9emx 159 24 and and CC cord-000580-dcid9emx 159 25 the the DT cord-000580-dcid9emx 159 26 script script NN cord-000580-dcid9emx 159 27 pfam_scan.pl pfam_scan.pl NN cord-000580-dcid9emx 159 28 , , , cord-000580-dcid9emx 159 29 which which WDT cord-000580-dcid9emx 159 30 was be VBD cord-000580-dcid9emx 159 31 obtained obtain VBN cord-000580-dcid9emx 159 32 from from IN cord-000580-dcid9emx 159 33 the the DT cord-000580-dcid9emx 159 34 Pfam Pfam NNP cord-000580-dcid9emx 159 35 ftp ftp JJ cord-000580-dcid9emx 159 36 - - HYPH cord-000580-dcid9emx 159 37 site site NN cord-000580-dcid9emx 159 38 ( ( -LRB- cord-000580-dcid9emx 159 39 ftp://ftp ftp://ftp NNP cord-000580-dcid9emx 159 40 . . . cord-000580-dcid9emx 160 1 sanger.ac.uk/pub/databases/Pfam/Tools/ sanger.ac.uk/pub/databases/Pfam/Tools/ NNP cord-000580-dcid9emx 160 2 ) ) -RRB- cord-000580-dcid9emx 160 3 , , , cord-000580-dcid9emx 160 4 with with IN cord-000580-dcid9emx 160 5 Pfam Pfam NNP cord-000580-dcid9emx 160 6 's 's POS cord-000580-dcid9emx 160 7 default default NN cord-000580-dcid9emx 160 8 settings setting NNS cord-000580-dcid9emx 160 9 . . . cord-000580-dcid9emx 161 1 In in IN cord-000580-dcid9emx 161 2 Pfam Pfam NNP cord-000580-dcid9emx 161 3 , , , cord-000580-dcid9emx 161 4 the the DT cord-000580-dcid9emx 161 5 IFITM IFITM NNP cord-000580-dcid9emx 161 6 family family NN cord-000580-dcid9emx 161 7 is be VBZ cord-000580-dcid9emx 161 8 represented represent VBN cord-000580-dcid9emx 161 9 by by IN cord-000580-dcid9emx 161 10 a a DT cord-000580-dcid9emx 161 11 specific specific JJ cord-000580-dcid9emx 161 12 hidden hide VBN cord-000580-dcid9emx 161 13 Markov Markov NNP cord-000580-dcid9emx 161 14 model model NN cord-000580-dcid9emx 161 15 [ [ -LRB- cord-000580-dcid9emx 161 16 Pfam Pfam NNP cord-000580-dcid9emx 161 17 : : : cord-000580-dcid9emx 161 18 P04505 P04505 NNP cord-000580-dcid9emx 161 19 ] ] -RRB- cord-000580-dcid9emx 161 20 . . . cord-000580-dcid9emx 162 1 All all PDT cord-000580-dcid9emx 162 2 the the DT cord-000580-dcid9emx 162 3 proteins protein NNS cord-000580-dcid9emx 162 4 that that WDT cord-000580-dcid9emx 162 5 were be VBD cord-000580-dcid9emx 162 6 assigned assign VBN cord-000580-dcid9emx 162 7 to to IN cord-000580-dcid9emx 162 8 this this DT cord-000580-dcid9emx 162 9 model model NN cord-000580-dcid9emx 162 10 in in IN cord-000580-dcid9emx 162 11 the the DT cord-000580-dcid9emx 162 12 Pfam Pfam NNP cord-000580-dcid9emx 162 13 - - HYPH cord-000580-dcid9emx 162 14 search search NN cord-000580-dcid9emx 162 15 were be VBD cord-000580-dcid9emx 162 16 considered consider VBN cord-000580-dcid9emx 162 17 to to TO cord-000580-dcid9emx 162 18 be be VB cord-000580-dcid9emx 162 19 homologous homologous JJ cord-000580-dcid9emx 162 20 to to IN cord-000580-dcid9emx 162 21 the the DT cord-000580-dcid9emx 162 22 IFITM IFITM NNP cord-000580-dcid9emx 162 23 family family NN cord-000580-dcid9emx 162 24 and and CC cord-000580-dcid9emx 162 25 were be VBD cord-000580-dcid9emx 162 26 therefore therefore RB cord-000580-dcid9emx 162 27 included include VBN cord-000580-dcid9emx 162 28 for for IN cord-000580-dcid9emx 162 29 further further JJ cord-000580-dcid9emx 162 30 analysis analysis NN cord-000580-dcid9emx 162 31 . . . cord-000580-dcid9emx 163 1 The the DT cord-000580-dcid9emx 163 2 script script NN cord-000580-dcid9emx 163 3 pfam_scan.pl pfam_scan.pl CD cord-000580-dcid9emx 163 4 uses use VBZ cord-000580-dcid9emx 163 5 the the DT cord-000580-dcid9emx 163 6 homology homology NN cord-000580-dcid9emx 163 7 criterion criterion NN cord-000580-dcid9emx 163 8 set set VBN cord-000580-dcid9emx 163 9 by by IN cord-000580-dcid9emx 163 10 the the DT cord-000580-dcid9emx 163 11 Pfam Pfam NNP cord-000580-dcid9emx 163 12 database database NN cord-000580-dcid9emx 163 13 , , , cord-000580-dcid9emx 163 14 which which WDT cord-000580-dcid9emx 163 15 is be VBZ cord-000580-dcid9emx 163 16 based base VBN cord-000580-dcid9emx 163 17 on on IN cord-000580-dcid9emx 163 18 a a DT cord-000580-dcid9emx 163 19 manually manually RB cord-000580-dcid9emx 163 20 curated curate VBN cord-000580-dcid9emx 163 21 gathering gathering NN cord-000580-dcid9emx 163 22 threshold threshold NN cord-000580-dcid9emx 163 23 for for IN cord-000580-dcid9emx 163 24 each each DT cord-000580-dcid9emx 163 25 model model NN cord-000580-dcid9emx 163 26 . . . cord-000580-dcid9emx 164 1 The the DT cord-000580-dcid9emx 164 2 gathering gathering NN cord-000580-dcid9emx 164 3 threshold threshold NN cord-000580-dcid9emx 164 4 for for IN cord-000580-dcid9emx 164 5 PF04505 pf04505 NN cord-000580-dcid9emx 164 6 is be VBZ cord-000580-dcid9emx 164 7 a a DT cord-000580-dcid9emx 164 8 score score NN cord-000580-dcid9emx 164 9 of of IN cord-000580-dcid9emx 164 10 20.6 20.6 CD cord-000580-dcid9emx 164 11 . . . cord-000580-dcid9emx 165 1 The the DT cord-000580-dcid9emx 165 2 sequence sequence NN cord-000580-dcid9emx 165 3 datasets dataset NNS cord-000580-dcid9emx 165 4 were be VBD cord-000580-dcid9emx 165 5 controlled control VBN cord-000580-dcid9emx 165 6 for for IN cord-000580-dcid9emx 165 7 annotated annotate VBN cord-000580-dcid9emx 165 8 pseudogenes pseudogene NNS cord-000580-dcid9emx 165 9 and and CC cord-000580-dcid9emx 165 10 transcript transcript NN cord-000580-dcid9emx 165 11 variants variant NNS cord-000580-dcid9emx 165 12 from from IN cord-000580-dcid9emx 165 13 the the DT cord-000580-dcid9emx 165 14 same same JJ cord-000580-dcid9emx 165 15 gene gene NN cord-000580-dcid9emx 165 16 . . . cord-000580-dcid9emx 166 1 In in IN cord-000580-dcid9emx 166 2 the the DT cord-000580-dcid9emx 166 3 case case NN cord-000580-dcid9emx 166 4 of of IN cord-000580-dcid9emx 166 5 multiple multiple JJ cord-000580-dcid9emx 166 6 transcript transcript NN cord-000580-dcid9emx 166 7 variants variant NNS cord-000580-dcid9emx 166 8 , , , cord-000580-dcid9emx 166 9 the the DT cord-000580-dcid9emx 166 10 longest long JJS cord-000580-dcid9emx 166 11 sequence sequence NN cord-000580-dcid9emx 166 12 was be VBD cord-000580-dcid9emx 166 13 kept keep VBN cord-000580-dcid9emx 166 14 . . . cord-000580-dcid9emx 167 1 The the DT cord-000580-dcid9emx 167 2 resulting result VBG cord-000580-dcid9emx 167 3 non non JJ cord-000580-dcid9emx 167 4 - - JJ cord-000580-dcid9emx 167 5 redundant redundant JJ cord-000580-dcid9emx 167 6 datasets dataset NNS cord-000580-dcid9emx 167 7 were be VBD cord-000580-dcid9emx 167 8 used use VBN cord-000580-dcid9emx 167 9 for for IN cord-000580-dcid9emx 167 10 the the DT cord-000580-dcid9emx 167 11 analysis analysis NN cord-000580-dcid9emx 167 12 . . . cord-000580-dcid9emx 168 1 The the DT cord-000580-dcid9emx 168 2 bacterial bacterial JJ cord-000580-dcid9emx 168 3 sequences sequence NNS cord-000580-dcid9emx 168 4 were be VBD cord-000580-dcid9emx 168 5 obtained obtain VBN cord-000580-dcid9emx 168 6 by by IN cord-000580-dcid9emx 168 7 querying query VBG cord-000580-dcid9emx 168 8 Uniprot Uniprot NNP cord-000580-dcid9emx 168 9 ( ( -LRB- cord-000580-dcid9emx 168 10 www.uniprot.org www.uniprot.org NNP cord-000580-dcid9emx 168 11 ) ) -RRB- cord-000580-dcid9emx 168 12 for for IN cord-000580-dcid9emx 168 13 the the DT cord-000580-dcid9emx 168 14 Pfam Pfam NNP cord-000580-dcid9emx 168 15 ID ID NNP cord-000580-dcid9emx 169 1 [ [ -LRB- cord-000580-dcid9emx 169 2 Pfam Pfam NNP cord-000580-dcid9emx 169 3 : : : cord-000580-dcid9emx 169 4 PF04505 pf04505 NN cord-000580-dcid9emx 169 5 ] ] -RRB- cord-000580-dcid9emx 169 6 . . . cord-000580-dcid9emx 170 1 Thereafter thereafter RB cord-000580-dcid9emx 170 2 , , , cord-000580-dcid9emx 170 3 the the DT cord-000580-dcid9emx 170 4 sequence sequence NN cord-000580-dcid9emx 170 5 set set NN cord-000580-dcid9emx 170 6 was be VBD cord-000580-dcid9emx 170 7 downloaded download VBN cord-000580-dcid9emx 170 8 by by IN cord-000580-dcid9emx 170 9 browsing browse VBG cord-000580-dcid9emx 170 10 by by IN cord-000580-dcid9emx 170 11 taxonomy taxonomy NN cord-000580-dcid9emx 170 12 and and CC cord-000580-dcid9emx 170 13 restricting restrict VBG cord-000580-dcid9emx 170 14 it -PRON- PRP cord-000580-dcid9emx 170 15 to to IN cord-000580-dcid9emx 170 16 species species VB cord-000580-dcid9emx 170 17 with with IN cord-000580-dcid9emx 170 18 a a DT cord-000580-dcid9emx 170 19 full full JJ cord-000580-dcid9emx 170 20 proteome proteome NN cord-000580-dcid9emx 170 21 set set NN cord-000580-dcid9emx 170 22 . . . cord-000580-dcid9emx 171 1 To to TO cord-000580-dcid9emx 171 2 assure assure VB cord-000580-dcid9emx 171 3 that that IN cord-000580-dcid9emx 171 4 no no DT cord-000580-dcid9emx 171 5 lineages lineage NNS cord-000580-dcid9emx 171 6 were be VBD cord-000580-dcid9emx 171 7 missing miss VBG cord-000580-dcid9emx 171 8 in in IN cord-000580-dcid9emx 171 9 the the DT cord-000580-dcid9emx 171 10 selection selection NN cord-000580-dcid9emx 171 11 of of IN cord-000580-dcid9emx 171 12 proteomes proteomes NNP cord-000580-dcid9emx 171 13 the the DT cord-000580-dcid9emx 171 14 nr nr NNP cord-000580-dcid9emx 171 15 protein protein NN cord-000580-dcid9emx 171 16 dataset dataset NN cord-000580-dcid9emx 171 17 from from IN cord-000580-dcid9emx 171 18 NCBI NCBI NNP cord-000580-dcid9emx 171 19 was be VBD cord-000580-dcid9emx 171 20 downloaded download VBN cord-000580-dcid9emx 171 21 . . . cord-000580-dcid9emx 172 1 The the DT cord-000580-dcid9emx 172 2 nr nr NN cord-000580-dcid9emx 172 3 datasets dataset NNS cord-000580-dcid9emx 172 4 contained contain VBN cord-000580-dcid9emx 172 5 15,322,545 15,322,545 CD cord-000580-dcid9emx 172 6 ( ( -LRB- cord-000580-dcid9emx 172 7 20 20 CD cord-000580-dcid9emx 172 8 - - SYM cord-000580-dcid9emx 172 9 09 09 CD cord-000580-dcid9emx 172 10 - - SYM cord-000580-dcid9emx 172 11 11 11 CD cord-000580-dcid9emx 172 12 ) ) -RRB- cord-000580-dcid9emx 172 13 protein protein NN cord-000580-dcid9emx 172 14 sequences sequence NNS cord-000580-dcid9emx 172 15 from from IN cord-000580-dcid9emx 172 16 a a DT cord-000580-dcid9emx 172 17 wide wide JJ cord-000580-dcid9emx 172 18 range range NN cord-000580-dcid9emx 172 19 of of IN cord-000580-dcid9emx 172 20 organisms organism NNS cord-000580-dcid9emx 172 21 . . . cord-000580-dcid9emx 173 1 The the DT cord-000580-dcid9emx 173 2 dataset dataset NN cord-000580-dcid9emx 173 3 was be VBD cord-000580-dcid9emx 173 4 searched search VBN cord-000580-dcid9emx 173 5 against against IN cord-000580-dcid9emx 173 6 the the DT cord-000580-dcid9emx 173 7 PF04505 PF04505 NNP cord-000580-dcid9emx 173 8 Pfam Pfam NNP cord-000580-dcid9emx 173 9 model model NN cord-000580-dcid9emx 173 10 using use VBG cord-000580-dcid9emx 173 11 HMMER3 HMMER3 NNP cord-000580-dcid9emx 173 12 with with IN cord-000580-dcid9emx 173 13 default default NN cord-000580-dcid9emx 173 14 settings setting NNS cord-000580-dcid9emx 173 15 and and CC cord-000580-dcid9emx 173 16 sequences sequence NNS cord-000580-dcid9emx 173 17 with with IN cord-000580-dcid9emx 173 18 a a DT cord-000580-dcid9emx 173 19 score score NN cord-000580-dcid9emx 173 20 above above IN cord-000580-dcid9emx 173 21 the the DT cord-000580-dcid9emx 173 22 Pfam Pfam NNP cord-000580-dcid9emx 173 23 gathering gathering NN cord-000580-dcid9emx 173 24 threshold threshold NN cord-000580-dcid9emx 173 25 ( ( -LRB- cord-000580-dcid9emx 173 26 20.6 20.6 CD cord-000580-dcid9emx 173 27 ) ) -RRB- cord-000580-dcid9emx 173 28 were be VBD cord-000580-dcid9emx 173 29 deemed deem VBN cord-000580-dcid9emx 173 30 as as IN cord-000580-dcid9emx 173 31 homologous homologous JJ cord-000580-dcid9emx 173 32 to to IN cord-000580-dcid9emx 173 33 IFITM IFITM NNP cord-000580-dcid9emx 173 34 . . . cord-000580-dcid9emx 174 1 Mafft Mafft NNP cord-000580-dcid9emx 174 2 - - HYPH cord-000580-dcid9emx 174 3 einsi einsi NNP cord-000580-dcid9emx 174 4 was be VBD cord-000580-dcid9emx 174 5 used use VBN cord-000580-dcid9emx 174 6 , , , cord-000580-dcid9emx 174 7 with with IN cord-000580-dcid9emx 174 8 default default NN cord-000580-dcid9emx 174 9 settings setting NNS cord-000580-dcid9emx 174 10 , , , cord-000580-dcid9emx 174 11 to to TO cord-000580-dcid9emx 174 12 create create VB cord-000580-dcid9emx 174 13 a a DT cord-000580-dcid9emx 174 14 multiple multiple JJ cord-000580-dcid9emx 174 15 sequence sequence NN cord-000580-dcid9emx 174 16 alignment alignment NN cord-000580-dcid9emx 174 17 ( ( -LRB- cord-000580-dcid9emx 174 18 MSA MSA NNP cord-000580-dcid9emx 174 19 ) ) -RRB- cord-000580-dcid9emx 174 20 for for IN cord-000580-dcid9emx 174 21 the the DT cord-000580-dcid9emx 174 22 vertebrate vertebrate JJ cord-000580-dcid9emx 174 23 protein protein NN cord-000580-dcid9emx 174 24 sequences sequence NNS cord-000580-dcid9emx 174 25 [ [ -LRB- cord-000580-dcid9emx 174 26 26 26 CD cord-000580-dcid9emx 174 27 ] ] -RRB- cord-000580-dcid9emx 174 28 . . . cord-000580-dcid9emx 175 1 The the DT cord-000580-dcid9emx 175 2 MSAs msa NNS cord-000580-dcid9emx 175 3 were be VBD cord-000580-dcid9emx 175 4 thereafter thereafter RB cord-000580-dcid9emx 175 5 examined examine VBN cord-000580-dcid9emx 175 6 and and CC cord-000580-dcid9emx 175 7 refined refine VBN cord-000580-dcid9emx 175 8 in in IN cord-000580-dcid9emx 175 9 Jalview Jalview NNP cord-000580-dcid9emx 175 10 2.5.1 2.5.1 CD cord-000580-dcid9emx 175 11 [ [ -LRB- cord-000580-dcid9emx 175 12 27 27 CD cord-000580-dcid9emx 175 13 ] ] -RRB- cord-000580-dcid9emx 175 14 , , , cord-000580-dcid9emx 175 15 i.e. i.e. FW cord-000580-dcid9emx 175 16 the the DT cord-000580-dcid9emx 175 17 sequences sequence NNS cord-000580-dcid9emx 175 18 were be VBD cord-000580-dcid9emx 175 19 trimmed trim VBN cord-000580-dcid9emx 175 20 and and CC cord-000580-dcid9emx 175 21 well well RB cord-000580-dcid9emx 175 22 conserved conserved JJ cord-000580-dcid9emx 175 23 and and CC cord-000580-dcid9emx 175 24 aligned align VBN cord-000580-dcid9emx 175 25 regions region NNS cord-000580-dcid9emx 175 26 were be VBD cord-000580-dcid9emx 175 27 kept keep VBN cord-000580-dcid9emx 175 28 , , , cord-000580-dcid9emx 175 29 which which WDT cord-000580-dcid9emx 175 30 included include VBD cord-000580-dcid9emx 175 31 82 82 CD cord-000580-dcid9emx 175 32 aligned align VBN cord-000580-dcid9emx 175 33 amino amino NN cord-000580-dcid9emx 175 34 acid acid NN cord-000580-dcid9emx 175 35 columns column NNS cord-000580-dcid9emx 175 36 . . . cord-000580-dcid9emx 176 1 Phylogenetic phylogenetic JJ cord-000580-dcid9emx 176 2 analysis analysis NN cord-000580-dcid9emx 176 3 was be VBD cord-000580-dcid9emx 176 4 performed perform VBN cord-000580-dcid9emx 176 5 with with IN cord-000580-dcid9emx 176 6 a a DT cord-000580-dcid9emx 176 7 Bayesian bayesian JJ cord-000580-dcid9emx 176 8 approach approach NN cord-000580-dcid9emx 176 9 implemented implement VBN cord-000580-dcid9emx 176 10 in in IN cord-000580-dcid9emx 176 11 MrBayes MrBayes NNP cord-000580-dcid9emx 176 12 [ [ -LRB- cord-000580-dcid9emx 176 13 28 28 CD cord-000580-dcid9emx 176 14 ] ] -RRB- cord-000580-dcid9emx 176 15 . . . cord-000580-dcid9emx 177 1 The the DT cord-000580-dcid9emx 177 2 following follow VBG cord-000580-dcid9emx 177 3 settings setting NNS cord-000580-dcid9emx 177 4 for for IN cord-000580-dcid9emx 177 5 the the DT cord-000580-dcid9emx 177 6 eukaryote eukaryote NN cord-000580-dcid9emx 177 7 proteins protein NNS cord-000580-dcid9emx 177 8 were be VBD cord-000580-dcid9emx 177 9 adjusted adjust VBN cord-000580-dcid9emx 177 10 : : : cord-000580-dcid9emx 177 11 The the DT cord-000580-dcid9emx 177 12 analysis analysis NN cord-000580-dcid9emx 177 13 was be VBD cord-000580-dcid9emx 177 14 run run VBN cord-000580-dcid9emx 177 15 using use VBG cord-000580-dcid9emx 177 16 a a DT cord-000580-dcid9emx 177 17 gamma gamma NN cord-000580-dcid9emx 177 18 shaped shape VBN cord-000580-dcid9emx 177 19 model model NN cord-000580-dcid9emx 177 20 for for IN cord-000580-dcid9emx 177 21 the the DT cord-000580-dcid9emx 177 22 variation variation NN cord-000580-dcid9emx 177 23 of of IN cord-000580-dcid9emx 177 24 evolutionary evolutionary JJ cord-000580-dcid9emx 177 25 rates rate NNS cord-000580-dcid9emx 177 26 across across IN cord-000580-dcid9emx 177 27 sites site NNS cord-000580-dcid9emx 177 28 ( ( -LRB- cord-000580-dcid9emx 177 29 rates rate NNS cord-000580-dcid9emx 177 30 = = SYM cord-000580-dcid9emx 177 31 gamma gamma NN cord-000580-dcid9emx 177 32 ) ) -RRB- cord-000580-dcid9emx 177 33 and and CC cord-000580-dcid9emx 177 34 the the DT cord-000580-dcid9emx 177 35 mixed mixed JJ cord-000580-dcid9emx 177 36 option option NN cord-000580-dcid9emx 177 37 ( ( -LRB- cord-000580-dcid9emx 177 38 aamodelpr aamodelpr NNP cord-000580-dcid9emx 177 39 = = SYM cord-000580-dcid9emx 177 40 mixed mix VBN cord-000580-dcid9emx 177 41 ) ) -RRB- cord-000580-dcid9emx 177 42 was be VBD cord-000580-dcid9emx 177 43 used use VBN cord-000580-dcid9emx 177 44 to to TO cord-000580-dcid9emx 177 45 estimate estimate VB cord-000580-dcid9emx 177 46 the the DT cord-000580-dcid9emx 177 47 best good JJS cord-000580-dcid9emx 177 48 amino amino NN cord-000580-dcid9emx 177 49 acid acid NN cord-000580-dcid9emx 177 50 substitution substitution NN cord-000580-dcid9emx 177 51 model model NN cord-000580-dcid9emx 177 52 . . . cord-000580-dcid9emx 178 1 We -PRON- PRP cord-000580-dcid9emx 178 2 generated generate VBD cord-000580-dcid9emx 178 3 5 5 CD cord-000580-dcid9emx 178 4 000 000 CD cord-000580-dcid9emx 178 5 000 000 CD cord-000580-dcid9emx 178 6 trees tree NNS cord-000580-dcid9emx 178 7 and and CC cord-000580-dcid9emx 178 8 the the DT cord-000580-dcid9emx 178 9 Markov Markov NNP cord-000580-dcid9emx 178 10 chain chain NN cord-000580-dcid9emx 179 1 Monte Monte NNP cord-000580-dcid9emx 179 2 Carlo Carlo NNP cord-000580-dcid9emx 179 3 analysis analysis NN cord-000580-dcid9emx 179 4 reached reach VBD cord-000580-dcid9emx 179 5 well well RB cord-000580-dcid9emx 179 6 below below IN cord-000580-dcid9emx 179 7 a a DT cord-000580-dcid9emx 179 8 standard standard JJ cord-000580-dcid9emx 179 9 deviation deviation NN cord-000580-dcid9emx 179 10 of of IN cord-000580-dcid9emx 179 11 split split JJ cord-000580-dcid9emx 179 12 frequencies frequency NNS cord-000580-dcid9emx 179 13 of of IN cord-000580-dcid9emx 179 14 0.01 0.01 CD cord-000580-dcid9emx 179 15 . . . cord-000580-dcid9emx 180 1 Each each DT cord-000580-dcid9emx 180 2 hundred hundred CD cord-000580-dcid9emx 180 3 tree tree NN cord-000580-dcid9emx 180 4 was be VBD cord-000580-dcid9emx 180 5 sampled sample VBN cord-000580-dcid9emx 180 6 from from IN cord-000580-dcid9emx 180 7 the the DT cord-000580-dcid9emx 180 8 mcmc mcmc NNP cord-000580-dcid9emx 180 9 run run NN cord-000580-dcid9emx 180 10 and and CC cord-000580-dcid9emx 180 11 the the DT cord-000580-dcid9emx 180 12 first first JJ cord-000580-dcid9emx 180 13 25 25 CD cord-000580-dcid9emx 180 14 % % NN cord-000580-dcid9emx 180 15 of of IN cord-000580-dcid9emx 180 16 the the DT cord-000580-dcid9emx 180 17 sampled sample VBN cord-000580-dcid9emx 180 18 trees tree NNS cord-000580-dcid9emx 180 19 were be VBD cord-000580-dcid9emx 180 20 discarded discard VBN cord-000580-dcid9emx 180 21 ( ( -LRB- cord-000580-dcid9emx 180 22 burnin burnin NNS cord-000580-dcid9emx 180 23 = = SYM cord-000580-dcid9emx 180 24 0.25 0.25 CD cord-000580-dcid9emx 180 25 ) ) -RRB- cord-000580-dcid9emx 180 26 to to TO cord-000580-dcid9emx 180 27 reassure reassure VB cord-000580-dcid9emx 180 28 a a DT cord-000580-dcid9emx 180 29 good good JJ cord-000580-dcid9emx 180 30 sample sample NN cord-000580-dcid9emx 180 31 from from IN cord-000580-dcid9emx 180 32 the the DT cord-000580-dcid9emx 180 33 posterior posterior JJ cord-000580-dcid9emx 180 34 probability probability NN cord-000580-dcid9emx 180 35 distribution distribution NN cord-000580-dcid9emx 180 36 . . . cord-000580-dcid9emx 181 1 A a DT cord-000580-dcid9emx 181 2 consensus consensus NN cord-000580-dcid9emx 181 3 tree tree NN cord-000580-dcid9emx 181 4 was be VBD cord-000580-dcid9emx 181 5 built build VBN cord-000580-dcid9emx 181 6 from from IN cord-000580-dcid9emx 181 7 the the DT cord-000580-dcid9emx 181 8 remaining remain VBG cord-000580-dcid9emx 181 9 37 37 CD cord-000580-dcid9emx 181 10 500 500 CD cord-000580-dcid9emx 181 11 trees tree NNS cord-000580-dcid9emx 181 12 with with IN cord-000580-dcid9emx 181 13 the the DT cord-000580-dcid9emx 181 14 MrBayes MrBayes NNP cord-000580-dcid9emx 181 15 sumt sumt NNP cord-000580-dcid9emx 181 16 command command NN cord-000580-dcid9emx 181 17 using use VBG cord-000580-dcid9emx 181 18 the the DT cord-000580-dcid9emx 181 19 50 50 CD cord-000580-dcid9emx 181 20 % % NN cord-000580-dcid9emx 181 21 majority majority NN cord-000580-dcid9emx 181 22 rule rule NN cord-000580-dcid9emx 181 23 method method NN cord-000580-dcid9emx 181 24 . . . cord-000580-dcid9emx 182 1 The the DT cord-000580-dcid9emx 182 2 sump sump NN cord-000580-dcid9emx 182 3 command command NN cord-000580-dcid9emx 182 4 was be VBD cord-000580-dcid9emx 182 5 used use VBN cord-000580-dcid9emx 182 6 to to TO cord-000580-dcid9emx 182 7 assure assure VB cord-000580-dcid9emx 182 8 that that IN cord-000580-dcid9emx 182 9 an an DT cord-000580-dcid9emx 182 10 adequate adequate JJ cord-000580-dcid9emx 182 11 sample sample NN cord-000580-dcid9emx 182 12 of of IN cord-000580-dcid9emx 182 13 the the DT cord-000580-dcid9emx 182 14 posterior posterior JJ cord-000580-dcid9emx 182 15 probability probability NN cord-000580-dcid9emx 182 16 distribution distribution NN cord-000580-dcid9emx 182 17 was be VBD cord-000580-dcid9emx 182 18 reached reach VBN cord-000580-dcid9emx 182 19 during during IN cord-000580-dcid9emx 182 20 the the DT cord-000580-dcid9emx 182 21 mcmc mcmc NNP cord-000580-dcid9emx 182 22 procedure procedure NN cord-000580-dcid9emx 182 23 . . . cord-000580-dcid9emx 183 1 To to TO cord-000580-dcid9emx 183 2 validate validate VB cord-000580-dcid9emx 183 3 the the DT cord-000580-dcid9emx 183 4 phylogenetic phylogenetic JJ cord-000580-dcid9emx 183 5 inference inference NN cord-000580-dcid9emx 183 6 with with IN cord-000580-dcid9emx 183 7 MrBayes MrBayes NNP cord-000580-dcid9emx 183 8 a a DT cord-000580-dcid9emx 183 9 maximum maximum JJ cord-000580-dcid9emx 183 10 likelihood likelihood NN cord-000580-dcid9emx 183 11 method method NN cord-000580-dcid9emx 183 12 implmemented implmemente VBN cord-000580-dcid9emx 183 13 in in IN cord-000580-dcid9emx 183 14 RAxML RAxML NNS cord-000580-dcid9emx 183 15 was be VBD cord-000580-dcid9emx 183 16 used use VBN cord-000580-dcid9emx 183 17 [ [ -LRB- cord-000580-dcid9emx 183 18 29 29 CD cord-000580-dcid9emx 183 19 ] ] -RRB- cord-000580-dcid9emx 183 20 . . . cord-000580-dcid9emx 184 1 The the DT cord-000580-dcid9emx 184 2 combined combine VBN cord-000580-dcid9emx 184 3 rapid rapid JJ cord-000580-dcid9emx 184 4 bootstrapping bootstrapping NN cord-000580-dcid9emx 184 5 and and CC cord-000580-dcid9emx 184 6 search search NN cord-000580-dcid9emx 184 7 for for IN cord-000580-dcid9emx 184 8 the the DT cord-000580-dcid9emx 184 9 bestscoring bestscore VBG cord-000580-dcid9emx 184 10 ML ML NNP cord-000580-dcid9emx 184 11 tree tree NN cord-000580-dcid9emx 184 12 option option NN cord-000580-dcid9emx 184 13 ( ( -LRB- cord-000580-dcid9emx 184 14 -f -f : cord-000580-dcid9emx 184 15 a a LS cord-000580-dcid9emx 184 16 ) ) -RRB- cord-000580-dcid9emx 184 17 in in IN cord-000580-dcid9emx 184 18 RAxML RAxML NNS cord-000580-dcid9emx 184 19 was be VBD cord-000580-dcid9emx 184 20 used use VBN cord-000580-dcid9emx 184 21 to to TO cord-000580-dcid9emx 184 22 create create VB cord-000580-dcid9emx 184 23 1000 1000 CD cord-000580-dcid9emx 184 24 bootstraps bootstrap NNS cord-000580-dcid9emx 184 25 ( ( -LRB- cord-000580-dcid9emx 184 26 - - : cord-000580-dcid9emx 184 27 # # $ cord-000580-dcid9emx 184 28 1000 1000 CD cord-000580-dcid9emx 184 29 ) ) -RRB- cord-000580-dcid9emx 184 30 using use VBG cord-000580-dcid9emx 184 31 a a DT cord-000580-dcid9emx 184 32 gamma gamma JJ cord-000580-dcid9emx 184 33 model model NN cord-000580-dcid9emx 184 34 of of IN cord-000580-dcid9emx 184 35 evolutionary evolutionary JJ cord-000580-dcid9emx 184 36 rates rate NNS cord-000580-dcid9emx 184 37 and and CC cord-000580-dcid9emx 184 38 the the DT cord-000580-dcid9emx 184 39 JTT JTT NNP cord-000580-dcid9emx 184 40 substitution substitution NN cord-000580-dcid9emx 184 41 model model NN cord-000580-dcid9emx 184 42 ( ( -LRB- cord-000580-dcid9emx 184 43 -m -m : cord-000580-dcid9emx 184 44 PROTGAMMAJTT PROTGAMMAJTT NNP cord-000580-dcid9emx 184 45 ) ) -RRB- cord-000580-dcid9emx 184 46 . . . cord-000580-dcid9emx 185 1 The the DT cord-000580-dcid9emx 185 2 JTT JTT NNP cord-000580-dcid9emx 185 3 substitution substitution NN cord-000580-dcid9emx 185 4 model model NN cord-000580-dcid9emx 185 5 was be VBD cord-000580-dcid9emx 185 6 identified identify VBN cord-000580-dcid9emx 185 7 as as IN cord-000580-dcid9emx 185 8 the the DT cord-000580-dcid9emx 185 9 most most RBS cord-000580-dcid9emx 185 10 suitable suitable JJ cord-000580-dcid9emx 185 11 model model NN cord-000580-dcid9emx 185 12 in in IN cord-000580-dcid9emx 185 13 the the DT cord-000580-dcid9emx 185 14 Bayesian bayesian JJ cord-000580-dcid9emx 185 15 analysis analysis NN cord-000580-dcid9emx 185 16 and and CC cord-000580-dcid9emx 185 17 therefore therefore RB cord-000580-dcid9emx 185 18 selected select VBN cord-000580-dcid9emx 185 19 for for IN cord-000580-dcid9emx 185 20 the the DT cord-000580-dcid9emx 185 21 maximum maximum JJ cord-000580-dcid9emx 185 22 likelihood likelihood NN cord-000580-dcid9emx 185 23 phylogeny phylogeny NN cord-000580-dcid9emx 185 24 . . . cord-000580-dcid9emx 186 1 The the DT cord-000580-dcid9emx 186 2 consensus consensus NN cord-000580-dcid9emx 186 3 phylogenetic phylogenetic NN cord-000580-dcid9emx 186 4 tree tree NN cord-000580-dcid9emx 186 5 found find VBN cord-000580-dcid9emx 186 6 with with IN cord-000580-dcid9emx 186 7 MrBayes MrBayes NNP cord-000580-dcid9emx 186 8 was be VBD cord-000580-dcid9emx 186 9 drawn draw VBN cord-000580-dcid9emx 186 10 in in IN cord-000580-dcid9emx 186 11 Dendroscope Dendroscope NNP cord-000580-dcid9emx 186 12 3.0 3.0 NNP cord-000580-dcid9emx 186 13 and and CC cord-000580-dcid9emx 186 14 the the DT cord-000580-dcid9emx 186 15 bootstrap bootstrap NN cord-000580-dcid9emx 186 16 support support NN cord-000580-dcid9emx 186 17 values value NNS cord-000580-dcid9emx 186 18 from from IN cord-000580-dcid9emx 186 19 RAxML RAxML NNS cord-000580-dcid9emx 186 20 were be VBD cord-000580-dcid9emx 186 21 annotated annotate VBN cord-000580-dcid9emx 186 22 on on IN cord-000580-dcid9emx 186 23 the the DT cord-000580-dcid9emx 186 24 corresponding correspond VBG cord-000580-dcid9emx 186 25 nodes node NNS cord-000580-dcid9emx 186 26 [ [ -LRB- cord-000580-dcid9emx 186 27 30 30 CD cord-000580-dcid9emx 186 28 ] ] -RRB- cord-000580-dcid9emx 186 29 . . . cord-000580-dcid9emx 187 1 The the DT cord-000580-dcid9emx 187 2 phylogenetic phylogenetic JJ cord-000580-dcid9emx 187 3 tree tree NN cord-000580-dcid9emx 187 4 was be VBD cord-000580-dcid9emx 187 5 used use VBN cord-000580-dcid9emx 187 6 to to TO cord-000580-dcid9emx 187 7 determine determine VB cord-000580-dcid9emx 187 8 subfamilies subfamily NNS cord-000580-dcid9emx 187 9 by by IN cord-000580-dcid9emx 187 10 identifying identify VBG cord-000580-dcid9emx 187 11 clusters cluster NNS cord-000580-dcid9emx 187 12 with with IN cord-000580-dcid9emx 187 13 a a DT cord-000580-dcid9emx 187 14 high high JJ cord-000580-dcid9emx 187 15 posterior posterior JJ cord-000580-dcid9emx 187 16 probability probability NN cord-000580-dcid9emx 187 17 and and CC cord-000580-dcid9emx 187 18 bootstrap bootstrap NN cord-000580-dcid9emx 187 19 support support NN cord-000580-dcid9emx 187 20 . . . cord-000580-dcid9emx 188 1 Invertebrate invertebrate JJ cord-000580-dcid9emx 188 2 sequences sequence NNS cord-000580-dcid9emx 188 3 were be VBD cord-000580-dcid9emx 188 4 excluded exclude VBN cord-000580-dcid9emx 188 5 from from IN cord-000580-dcid9emx 188 6 the the DT cord-000580-dcid9emx 188 7 phylogenetic phylogenetic JJ cord-000580-dcid9emx 188 8 analysis analysis NN cord-000580-dcid9emx 188 9 as as IN cord-000580-dcid9emx 188 10 they -PRON- PRP cord-000580-dcid9emx 188 11 induced induce VBD cord-000580-dcid9emx 188 12 highly highly RB cord-000580-dcid9emx 188 13 unstable unstable JJ cord-000580-dcid9emx 188 14 topologies topology NNS cord-000580-dcid9emx 188 15 together together RB cord-000580-dcid9emx 188 16 with with IN cord-000580-dcid9emx 188 17 1 1 CD cord-000580-dcid9emx 188 18 M. m. NN cord-000580-dcid9emx 188 19 musculus musculus NN cord-000580-dcid9emx 188 20 , , , cord-000580-dcid9emx 188 21 2 2 CD cord-000580-dcid9emx 188 22 D. D. NNP cord-000580-dcid9emx 188 23 rerio rerio NNP cord-000580-dcid9emx 188 24 and and CC cord-000580-dcid9emx 188 25 3 3 CD cord-000580-dcid9emx 188 26 X. X. NNP cord-000580-dcid9emx 188 27 tropicalis tropicalis NNP cord-000580-dcid9emx 188 28 sequences sequence NNS cord-000580-dcid9emx 188 29 . . . cord-000580-dcid9emx 189 1 These these DT cord-000580-dcid9emx 189 2 excluded exclude VBN cord-000580-dcid9emx 189 3 sequences sequence NNS cord-000580-dcid9emx 189 4 were be VBD cord-000580-dcid9emx 189 5 categorized categorize VBN cord-000580-dcid9emx 189 6 into into IN cord-000580-dcid9emx 189 7 their -PRON- PRP$ cord-000580-dcid9emx 189 8 respective respective JJ cord-000580-dcid9emx 189 9 subfamilies subfamily NNS cord-000580-dcid9emx 189 10 by by IN cord-000580-dcid9emx 189 11 using use VBG cord-000580-dcid9emx 189 12 a a DT cord-000580-dcid9emx 189 13 BLAST blast NN cord-000580-dcid9emx 189 14 search search NN cord-000580-dcid9emx 189 15 towards towards IN cord-000580-dcid9emx 189 16 the the DT cord-000580-dcid9emx 189 17 categorized categorize VBN cord-000580-dcid9emx 189 18 sequences sequence NNS cord-000580-dcid9emx 189 19 . . . cord-000580-dcid9emx 190 1 The the DT cord-000580-dcid9emx 190 2 top top JJ cord-000580-dcid9emx 190 3 five five CD cord-000580-dcid9emx 190 4 hits hit NNS cord-000580-dcid9emx 190 5 were be VBD cord-000580-dcid9emx 190 6 examined examine VBN cord-000580-dcid9emx 190 7 to to TO cord-000580-dcid9emx 190 8 classify classify VB cord-000580-dcid9emx 190 9 the the DT cord-000580-dcid9emx 190 10 invertebrate invertebrate NN cord-000580-dcid9emx 190 11 and and CC cord-000580-dcid9emx 190 12 excluded exclude VBN cord-000580-dcid9emx 190 13 sequences sequence NNS cord-000580-dcid9emx 190 14 into into IN cord-000580-dcid9emx 190 15 subfamilies subfamily NNS cord-000580-dcid9emx 190 16 . . . cord-000580-dcid9emx 191 1 A a DT cord-000580-dcid9emx 191 2 sequence sequence NN cord-000580-dcid9emx 191 3 was be VBD cord-000580-dcid9emx 191 4 assigned assign VBN cord-000580-dcid9emx 191 5 to to IN cord-000580-dcid9emx 191 6 the the DT cord-000580-dcid9emx 191 7 subfamily subfamily NN cord-000580-dcid9emx 191 8 if if IN cord-000580-dcid9emx 191 9 four four CD cord-000580-dcid9emx 191 10 out out IN cord-000580-dcid9emx 191 11 of of IN cord-000580-dcid9emx 191 12 the the DT cord-000580-dcid9emx 191 13 five five CD cord-000580-dcid9emx 191 14 top top JJ cord-000580-dcid9emx 191 15 hits hit NNS cord-000580-dcid9emx 191 16 are be VBP cord-000580-dcid9emx 191 17 from from IN cord-000580-dcid9emx 191 18 the the DT cord-000580-dcid9emx 191 19 same same JJ cord-000580-dcid9emx 191 20 subfamily subfamily NN cord-000580-dcid9emx 191 21 . . . cord-000580-dcid9emx 192 1 Several several JJ cord-000580-dcid9emx 192 2 resources resource NNS cord-000580-dcid9emx 192 3 were be VBD cord-000580-dcid9emx 192 4 used use VBN cord-000580-dcid9emx 192 5 to to TO cord-000580-dcid9emx 192 6 identify identify VB cord-000580-dcid9emx 192 7 the the DT cord-000580-dcid9emx 192 8 protein protein NN cord-000580-dcid9emx 192 9 sequence sequence NN cord-000580-dcid9emx 192 10 features feature NNS cord-000580-dcid9emx 192 11 of of IN cord-000580-dcid9emx 192 12 the the DT cord-000580-dcid9emx 192 13 Dispanins Dispanins NNPS cord-000580-dcid9emx 192 14 . . . cord-000580-dcid9emx 193 1 NetPhos NetPhos NNP cord-000580-dcid9emx 193 2 2.0 2.0 CD cord-000580-dcid9emx 193 3 [ [ -LRB- cord-000580-dcid9emx 193 4 31 31 CD cord-000580-dcid9emx 193 5 ] ] -RRB- cord-000580-dcid9emx 193 6 identified identify VBN cord-000580-dcid9emx 193 7 potential potential JJ cord-000580-dcid9emx 193 8 phosphorylation phosphorylation NN cord-000580-dcid9emx 193 9 sites site NNS cord-000580-dcid9emx 193 10 . . . cord-000580-dcid9emx 194 1 NetNGlyc NetNGlyc NNP cord-000580-dcid9emx 194 2 1.0 1.0 CD cord-000580-dcid9emx 194 3 and and CC cord-000580-dcid9emx 194 4 NetOGlyc netoglyc JJ cord-000580-dcid9emx 194 5 3.1 3.1 CD cord-000580-dcid9emx 194 6 [ [ -LRB- cord-000580-dcid9emx 194 7 32 32 CD cord-000580-dcid9emx 194 8 ] ] -RRB- cord-000580-dcid9emx 194 9 were be VBD cord-000580-dcid9emx 194 10 used use VBN cord-000580-dcid9emx 194 11 to to TO cord-000580-dcid9emx 194 12 find find VB cord-000580-dcid9emx 194 13 possible possible JJ cord-000580-dcid9emx 194 14 N n CD cord-000580-dcid9emx 194 15 - - : cord-000580-dcid9emx 194 16 and and CC cord-000580-dcid9emx 194 17 O o NN cord-000580-dcid9emx 194 18 - - HYPH cord-000580-dcid9emx 194 19 glycosylation glycosylation NN cord-000580-dcid9emx 194 20 sites site NNS cord-000580-dcid9emx 194 21 respectively respectively RB cord-000580-dcid9emx 194 22 . . . cord-000580-dcid9emx 195 1 Transmembrane Transmembrane NNP cord-000580-dcid9emx 195 2 helix helix NN cord-000580-dcid9emx 195 3 prediction prediction NN cord-000580-dcid9emx 195 4 was be VBD cord-000580-dcid9emx 195 5 made make VBN cord-000580-dcid9emx 195 6 using use VBG cord-000580-dcid9emx 195 7 TMHMM TMHMM NNP cord-000580-dcid9emx 195 8 2.0 2.0 CD cord-000580-dcid9emx 195 9 [ [ -LRB- cord-000580-dcid9emx 195 10 33 33 CD cord-000580-dcid9emx 195 11 ] ] -RRB- cord-000580-dcid9emx 195 12 . . . cord-000580-dcid9emx 196 1 Motifs motif NNS cord-000580-dcid9emx 196 2 were be VBD cord-000580-dcid9emx 196 3 found find VBN cord-000580-dcid9emx 196 4 manually manually RB cord-000580-dcid9emx 196 5 through through IN cord-000580-dcid9emx 196 6 Jalview Jalview NNP cord-000580-dcid9emx 196 7 2.5.1 2.5.1 CD cord-000580-dcid9emx 197 1 and and CC cord-000580-dcid9emx 197 2 the the DT cord-000580-dcid9emx 197 3 server server NN cord-000580-dcid9emx 197 4 MEME meme NN cord-000580-dcid9emx 197 5 4.4.0 4.4.0 CD cord-000580-dcid9emx 197 6 . . . cord-000580-dcid9emx 198 1 Finally finally RB cord-000580-dcid9emx 198 2 , , , cord-000580-dcid9emx 198 3 EMBOSS emboss VB cord-000580-dcid9emx 198 4 : : : cord-000580-dcid9emx 199 1 cons con NNS cord-000580-dcid9emx 199 2 was be VBD cord-000580-dcid9emx 199 3 used use VBN cord-000580-dcid9emx 199 4 to to TO cord-000580-dcid9emx 199 5 create create VB cord-000580-dcid9emx 199 6 consensus consensus NN cord-000580-dcid9emx 199 7 sequences sequence NNS cord-000580-dcid9emx 199 8 of of IN cord-000580-dcid9emx 199 9 the the DT cord-000580-dcid9emx 199 10 different different JJ cord-000580-dcid9emx 199 11 Dispanin Dispanin NNP cord-000580-dcid9emx 199 12 families family NNS cord-000580-dcid9emx 199 13 that that WDT cord-000580-dcid9emx 199 14 emerged emerge VBD cord-000580-dcid9emx 199 15 from from IN cord-000580-dcid9emx 199 16 the the DT cord-000580-dcid9emx 199 17 phylogenetic phylogenetic JJ cord-000580-dcid9emx 199 18 analysis analysis NN cord-000580-dcid9emx 199 19 and and CC cord-000580-dcid9emx 199 20 the the DT cord-000580-dcid9emx 199 21 bacterial bacterial JJ cord-000580-dcid9emx 199 22 sequences sequence NNS cord-000580-dcid9emx 199 23 . . . cord-000580-dcid9emx 200 1 The the DT cord-000580-dcid9emx 200 2 consensus consensus NN cord-000580-dcid9emx 200 3 sequences sequence NNS cord-000580-dcid9emx 200 4 were be VBD cord-000580-dcid9emx 200 5 aligned align VBN cord-000580-dcid9emx 200 6 together together RB cord-000580-dcid9emx 200 7 with with IN cord-000580-dcid9emx 200 8 the the DT cord-000580-dcid9emx 200 9 M. M. NNP cord-000580-dcid9emx 200 10 brevicollis brevicollis NNP cord-000580-dcid9emx 200 11 and and CC cord-000580-dcid9emx 200 12 the the DT cord-000580-dcid9emx 200 13 invertebrate invertebrate JJ cord-000580-dcid9emx 200 14 sequences sequence NNS cord-000580-dcid9emx 200 15 . . . cord-000580-dcid9emx 201 1 The the DT cord-000580-dcid9emx 201 2 resulting result VBG cord-000580-dcid9emx 201 3 MSA MSA NNP cord-000580-dcid9emx 201 4 was be VBD cord-000580-dcid9emx 201 5 viewed view VBN cord-000580-dcid9emx 201 6 and and CC cord-000580-dcid9emx 201 7 trimmed trim VBN cord-000580-dcid9emx 201 8 in in IN cord-000580-dcid9emx 201 9 Jalview Jalview NNP cord-000580-dcid9emx 201 10 and and CC cord-000580-dcid9emx 201 11 the the DT cord-000580-dcid9emx 201 12 conserved conserve VBN cord-000580-dcid9emx 201 13 region region NN cord-000580-dcid9emx 201 14 around around IN cord-000580-dcid9emx 201 15 the the DT cord-000580-dcid9emx 201 16 TM TM NNP cord-000580-dcid9emx 201 17 helices helix NNS cord-000580-dcid9emx 201 18 was be VBD cord-000580-dcid9emx 201 19 kept keep VBN cord-000580-dcid9emx 201 20 . . . cord-000580-dcid9emx 202 1 Splice splice NN cord-000580-dcid9emx 202 2 sites site NNS cord-000580-dcid9emx 202 3 were be VBD cord-000580-dcid9emx 202 4 detected detect VBN cord-000580-dcid9emx 202 5 in in IN cord-000580-dcid9emx 202 6 the the DT cord-000580-dcid9emx 202 7 eukaryotic eukaryotic JJ cord-000580-dcid9emx 202 8 Dispanins Dispanins NNPS cord-000580-dcid9emx 202 9 by by IN cord-000580-dcid9emx 202 10 studying study VBG cord-000580-dcid9emx 202 11 their -PRON- PRP$ cord-000580-dcid9emx 202 12 annotation annotation NN cord-000580-dcid9emx 202 13 in in IN cord-000580-dcid9emx 202 14 the the DT cord-000580-dcid9emx 202 15 respective respective JJ cord-000580-dcid9emx 202 16 databases database NNS cord-000580-dcid9emx 202 17 and and CC cord-000580-dcid9emx 202 18 align align VB cord-000580-dcid9emx 202 19 them -PRON- PRP cord-000580-dcid9emx 202 20 to to IN cord-000580-dcid9emx 202 21 their -PRON- PRP$ cord-000580-dcid9emx 202 22 genome genome NN cord-000580-dcid9emx 202 23 using use VBG cord-000580-dcid9emx 202 24 BLAT BLAT NNP cord-000580-dcid9emx 202 25 at at IN cord-000580-dcid9emx 202 26 the the DT cord-000580-dcid9emx 202 27 UCSC UCSC NNP cord-000580-dcid9emx 202 28 Genome Genome NNP cord-000580-dcid9emx 202 29 Browser Browser NNP cord-000580-dcid9emx 202 30 website website NN cord-000580-dcid9emx 202 31 ( ( -LRB- cord-000580-dcid9emx 202 32 http://genome.ucsc.edu http://genome.ucsc.edu NNP cord-000580-dcid9emx 202 33 ) ) -RRB- cord-000580-dcid9emx 202 34 . . . cord-000580-dcid9emx 203 1 Table table NN cord-000580-dcid9emx 203 2 S1 S1 NNP cord-000580-dcid9emx 204 1 This this DT cord-000580-dcid9emx 204 2 is be VBZ cord-000580-dcid9emx 204 3 a a DT cord-000580-dcid9emx 204 4 record record NN cord-000580-dcid9emx 204 5 of of IN cord-000580-dcid9emx 204 6 all all DT cord-000580-dcid9emx 204 7 identified identify VBN cord-000580-dcid9emx 204 8 Dispanins Dispanins NNP cord-000580-dcid9emx 204 9 together together RB cord-000580-dcid9emx 204 10 with with IN cord-000580-dcid9emx 204 11 their -PRON- PRP$ cord-000580-dcid9emx 204 12 accession accession NN cord-000580-dcid9emx 204 13 numbers number NNS cord-000580-dcid9emx 204 14 , , , cord-000580-dcid9emx 204 15 nomenclature nomenclature NN cord-000580-dcid9emx 204 16 and and CC cord-000580-dcid9emx 204 17 species species NN cord-000580-dcid9emx 204 18 belonging belong VBG cord-000580-dcid9emx 204 19 . . . cord-000580-dcid9emx 205 1 ( ( -LRB- cord-000580-dcid9emx 205 2 XLS XLS NNP cord-000580-dcid9emx 205 3 ) ) -RRB- cord-000580-dcid9emx 205 4 _SP cord-000580-dcid9emx 205 5 Trends trend NNS cord-000580-dcid9emx 205 6 in in IN cord-000580-dcid9emx 205 7 the the DT cord-000580-dcid9emx 205 8 exploitation exploitation NN cord-000580-dcid9emx 205 9 of of IN cord-000580-dcid9emx 205 10 novel novel JJ cord-000580-dcid9emx 205 11 drug drug NN cord-000580-dcid9emx 205 12 targets target NNS cord-000580-dcid9emx 205 13 Mapping map VBG cord-000580-dcid9emx 205 14 the the DT cord-000580-dcid9emx 205 15 human human JJ cord-000580-dcid9emx 205 16 membrane membrane NN cord-000580-dcid9emx 205 17 proteome proteome NN cord-000580-dcid9emx 205 18 : : : cord-000580-dcid9emx 205 19 a a DT cord-000580-dcid9emx 205 20 majority majority NN cord-000580-dcid9emx 205 21 of of IN cord-000580-dcid9emx 205 22 the the DT cord-000580-dcid9emx 205 23 human human JJ cord-000580-dcid9emx 205 24 membrane membrane NN cord-000580-dcid9emx 205 25 proteins protein NNS cord-000580-dcid9emx 205 26 can can MD cord-000580-dcid9emx 205 27 be be VB cord-000580-dcid9emx 205 28 classified classify VBN cord-000580-dcid9emx 205 29 according accord VBG cord-000580-dcid9emx 205 30 to to IN cord-000580-dcid9emx 205 31 function function NN cord-000580-dcid9emx 205 32 and and CC cord-000580-dcid9emx 205 33 evolutionary evolutionary JJ cord-000580-dcid9emx 205 34 origin origin NN cord-000580-dcid9emx 206 1 The the DT cord-000580-dcid9emx 206 2 G g NN cord-000580-dcid9emx 206 3 - - HYPH cord-000580-dcid9emx 206 4 proteincoupled proteincouple VBN cord-000580-dcid9emx 206 5 receptors receptor NNS cord-000580-dcid9emx 206 6 in in IN cord-000580-dcid9emx 206 7 the the DT cord-000580-dcid9emx 206 8 human human JJ cord-000580-dcid9emx 206 9 genome genome NN cord-000580-dcid9emx 206 10 form form NN cord-000580-dcid9emx 206 11 five five CD cord-000580-dcid9emx 206 12 main main JJ cord-000580-dcid9emx 206 13 families family NNS cord-000580-dcid9emx 206 14 . . . cord-000580-dcid9emx 207 1 Phylogenetic phylogenetic JJ cord-000580-dcid9emx 207 2 analysis analysis NN cord-000580-dcid9emx 207 3 , , , cord-000580-dcid9emx 207 4 paralogon paralogon NNP cord-000580-dcid9emx 207 5 groups group NNS cord-000580-dcid9emx 207 6 , , , cord-000580-dcid9emx 207 7 and and CC cord-000580-dcid9emx 207 8 fingerprints fingerprint VBZ cord-000580-dcid9emx 207 9 Structural structural JJ cord-000580-dcid9emx 207 10 diversity diversity NN cord-000580-dcid9emx 207 11 of of IN cord-000580-dcid9emx 207 12 G g NN cord-000580-dcid9emx 207 13 protein protein NN cord-000580-dcid9emx 207 14 - - HYPH cord-000580-dcid9emx 207 15 coupled couple VBN cord-000580-dcid9emx 207 16 receptors receptor NNS cord-000580-dcid9emx 207 17 and and CC cord-000580-dcid9emx 207 18 significance significance NN cord-000580-dcid9emx 207 19 for for IN cord-000580-dcid9emx 207 20 drug drug NN cord-000580-dcid9emx 207 21 discovery discovery NN cord-000580-dcid9emx 208 1 The the DT cord-000580-dcid9emx 208 2 solute solute NN cord-000580-dcid9emx 208 3 carrier carrier NN cord-000580-dcid9emx 208 4 ( ( -LRB- cord-000580-dcid9emx 208 5 SLC SLC NNP cord-000580-dcid9emx 208 6 ) ) -RRB- cord-000580-dcid9emx 208 7 complement complement NN cord-000580-dcid9emx 208 8 of of IN cord-000580-dcid9emx 208 9 the the DT cord-000580-dcid9emx 208 10 human human JJ cord-000580-dcid9emx 208 11 genome genome NN cord-000580-dcid9emx 208 12 : : : cord-000580-dcid9emx 209 1 phylogenetic phylogenetic JJ cord-000580-dcid9emx 209 2 classification classification NN cord-000580-dcid9emx 209 3 reveals reveal VBZ cord-000580-dcid9emx 209 4 four four CD cord-000580-dcid9emx 209 5 major major JJ cord-000580-dcid9emx 209 6 families family NNS cord-000580-dcid9emx 209 7 Transcriptional Transcriptional NNP cord-000580-dcid9emx 209 8 and and CC cord-000580-dcid9emx 209 9 posttranscriptional posttranscriptional JJ cord-000580-dcid9emx 209 10 regulation regulation NN cord-000580-dcid9emx 209 11 of of IN cord-000580-dcid9emx 209 12 interferon interferon NN cord-000580-dcid9emx 209 13 - - HYPH cord-000580-dcid9emx 209 14 induced induce VBN cord-000580-dcid9emx 209 15 gene gene NN cord-000580-dcid9emx 209 16 expression expression NN cord-000580-dcid9emx 209 17 in in IN cord-000580-dcid9emx 209 18 human human JJ cord-000580-dcid9emx 209 19 cells cell NNS cord-000580-dcid9emx 210 1 The the DT cord-000580-dcid9emx 210 2 IFITM IFITM NNP cord-000580-dcid9emx 210 3 proteins protein NNS cord-000580-dcid9emx 210 4 inhibit inhibit VBP cord-000580-dcid9emx 210 5 HIV-1 HIV-1 NNP cord-000580-dcid9emx 210 6 infection infection NN cord-000580-dcid9emx 211 1 The the DT cord-000580-dcid9emx 211 2 IFITM IFITM NNP cord-000580-dcid9emx 211 3 proteins protein NNS cord-000580-dcid9emx 211 4 mediate mediate VBP cord-000580-dcid9emx 211 5 cellular cellular JJ cord-000580-dcid9emx 211 6 resistance resistance NN cord-000580-dcid9emx 211 7 to to TO cord-000580-dcid9emx 211 8 influenza influenza VB cord-000580-dcid9emx 211 9 A a DT cord-000580-dcid9emx 211 10 H1N1 H1N1 NNP cord-000580-dcid9emx 211 11 virus virus NN cord-000580-dcid9emx 211 12 , , , cord-000580-dcid9emx 211 13 West West NNP cord-000580-dcid9emx 211 14 Nile Nile NNP cord-000580-dcid9emx 211 15 virus virus NN cord-000580-dcid9emx 211 16 , , , cord-000580-dcid9emx 211 17 and and CC cord-000580-dcid9emx 211 18 dengue dengue NN cord-000580-dcid9emx 211 19 virus virus NN cord-000580-dcid9emx 211 20 Identification identification NN cord-000580-dcid9emx 211 21 of of IN cord-000580-dcid9emx 211 22 five five CD cord-000580-dcid9emx 211 23 interferon interferon NN cord-000580-dcid9emx 211 24 - - HYPH cord-000580-dcid9emx 211 25 induced induce VBN cord-000580-dcid9emx 211 26 cellular cellular JJ cord-000580-dcid9emx 211 27 proteins protein NNS cord-000580-dcid9emx 211 28 that that WDT cord-000580-dcid9emx 211 29 inhibit inhibit VBP cord-000580-dcid9emx 211 30 west west NNP cord-000580-dcid9emx 211 31 nile nile NNP cord-000580-dcid9emx 211 32 virus virus NN cord-000580-dcid9emx 211 33 and and CC cord-000580-dcid9emx 211 34 dengue dengue NN cord-000580-dcid9emx 211 35 virus virus NN cord-000580-dcid9emx 211 36 infections infection NNS cord-000580-dcid9emx 212 1 Distinct distinct JJ cord-000580-dcid9emx 212 2 patterns pattern NNS cord-000580-dcid9emx 212 3 of of IN cord-000580-dcid9emx 212 4 IFITM ifitm NN cord-000580-dcid9emx 212 5 - - HYPH cord-000580-dcid9emx 212 6 mediated mediate VBN cord-000580-dcid9emx 212 7 restriction restriction NN cord-000580-dcid9emx 212 8 of of IN cord-000580-dcid9emx 212 9 filoviruses filovirus NNS cord-000580-dcid9emx 212 10 , , , cord-000580-dcid9emx 212 11 SARS SARS NNP cord-000580-dcid9emx 212 12 coronavirus coronavirus NN cord-000580-dcid9emx 212 13 , , , cord-000580-dcid9emx 212 14 and and CC cord-000580-dcid9emx 212 15 influenza influenza NN cord-000580-dcid9emx 212 16 A a DT cord-000580-dcid9emx 212 17 virus virus NN cord-000580-dcid9emx 212 18 Identification identification NN cord-000580-dcid9emx 212 19 of of IN cord-000580-dcid9emx 212 20 the the DT cord-000580-dcid9emx 212 21 IFITM IFITM NNP cord-000580-dcid9emx 212 22 family family NN cord-000580-dcid9emx 212 23 as as IN cord-000580-dcid9emx 212 24 a a DT cord-000580-dcid9emx 212 25 new new JJ cord-000580-dcid9emx 212 26 molecular molecular JJ cord-000580-dcid9emx 212 27 marker marker NN cord-000580-dcid9emx 212 28 in in IN cord-000580-dcid9emx 212 29 human human JJ cord-000580-dcid9emx 212 30 colorectal colorectal JJ cord-000580-dcid9emx 212 31 tumors tumor NNS cord-000580-dcid9emx 212 32 Characterization characterization NN cord-000580-dcid9emx 212 33 of of IN cord-000580-dcid9emx 212 34 the the DT cord-000580-dcid9emx 212 35 osteoblast osteoblast JJ cord-000580-dcid9emx 212 36 - - HYPH cord-000580-dcid9emx 212 37 specific specific JJ cord-000580-dcid9emx 212 38 transmembrane transmembrane NN cord-000580-dcid9emx 212 39 protein protein NN cord-000580-dcid9emx 212 40 IFITM5 IFITM5 NNP cord-000580-dcid9emx 212 41 and and CC cord-000580-dcid9emx 212 42 analysis analysis NN cord-000580-dcid9emx 212 43 of of IN cord-000580-dcid9emx 212 44 IFITM5-deficient ifitm5-deficient CD cord-000580-dcid9emx 212 45 mice mice NN cord-000580-dcid9emx 212 46 IFITM/ IFITM/ NNP cord-000580-dcid9emx 213 1 Mil/ Mil/ NNP cord-000580-dcid9emx 213 2 fragilis fragilis NN cord-000580-dcid9emx 213 3 family family NN cord-000580-dcid9emx 213 4 proteins protein VBZ cord-000580-dcid9emx 213 5 IFITM1 IFITM1 NNS cord-000580-dcid9emx 213 6 and and CC cord-000580-dcid9emx 213 7 IFITM3 IFITM3 NNP cord-000580-dcid9emx 213 8 play play VBP cord-000580-dcid9emx 213 9 distinct distinct JJ cord-000580-dcid9emx 213 10 roles role NNS cord-000580-dcid9emx 213 11 in in IN cord-000580-dcid9emx 213 12 mouse mouse NN cord-000580-dcid9emx 213 13 primordial primordial JJ cord-000580-dcid9emx 213 14 germ germ NN cord-000580-dcid9emx 213 15 cell cell NN cord-000580-dcid9emx 213 16 homing homing NN cord-000580-dcid9emx 213 17 and and CC cord-000580-dcid9emx 213 18 repulsion repulsion NN cord-000580-dcid9emx 213 19 Bril Bril NNP cord-000580-dcid9emx 213 20 : : : cord-000580-dcid9emx 213 21 a a DT cord-000580-dcid9emx 213 22 novel novel JJ cord-000580-dcid9emx 213 23 bone bone NN cord-000580-dcid9emx 213 24 - - HYPH cord-000580-dcid9emx 213 25 specific specific JJ cord-000580-dcid9emx 213 26 modulator modulator NN cord-000580-dcid9emx 213 27 of of IN cord-000580-dcid9emx 213 28 mineralization mineralization NN cord-000580-dcid9emx 213 29 TimeTree TimeTree NNP cord-000580-dcid9emx 213 30 : : : cord-000580-dcid9emx 213 31 a a DT cord-000580-dcid9emx 213 32 public public JJ cord-000580-dcid9emx 213 33 knowledge knowledge NN cord-000580-dcid9emx 213 34 - - HYPH cord-000580-dcid9emx 213 35 base base NN cord-000580-dcid9emx 213 36 of of IN cord-000580-dcid9emx 213 37 divergence divergence NN cord-000580-dcid9emx 213 38 times time NNS cord-000580-dcid9emx 213 39 among among IN cord-000580-dcid9emx 213 40 organisms organism NNS cord-000580-dcid9emx 213 41 Capucin Capucin NNP cord-000580-dcid9emx 213 42 : : : cord-000580-dcid9emx 213 43 a a DT cord-000580-dcid9emx 213 44 novel novel JJ cord-000580-dcid9emx 213 45 striatal striatal JJ cord-000580-dcid9emx 213 46 marker marker NN cord-000580-dcid9emx 213 47 down down RB cord-000580-dcid9emx 213 48 - - HYPH cord-000580-dcid9emx 213 49 regulated regulate VBN cord-000580-dcid9emx 213 50 in in IN cord-000580-dcid9emx 213 51 rodent rodent NN cord-000580-dcid9emx 213 52 models model NNS cord-000580-dcid9emx 213 53 of of IN cord-000580-dcid9emx 213 54 Huntington Huntington NNP cord-000580-dcid9emx 213 55 disease disease NN cord-000580-dcid9emx 213 56 BioGPS BioGPS NNP cord-000580-dcid9emx 213 57 : : : cord-000580-dcid9emx 213 58 an an DT cord-000580-dcid9emx 213 59 extensible extensible JJ cord-000580-dcid9emx 213 60 and and CC cord-000580-dcid9emx 213 61 customizable customizable JJ cord-000580-dcid9emx 213 62 portal portal NN cord-000580-dcid9emx 213 63 for for IN cord-000580-dcid9emx 213 64 querying query VBG cord-000580-dcid9emx 213 65 and and CC cord-000580-dcid9emx 213 66 organizing organize VBG cord-000580-dcid9emx 213 67 gene gene NN cord-000580-dcid9emx 213 68 annotation annotation NN cord-000580-dcid9emx 213 69 resources resource NNS cord-000580-dcid9emx 213 70 Characterization characterization NN cord-000580-dcid9emx 213 71 of of IN cord-000580-dcid9emx 213 72 Tusc5 Tusc5 NNP cord-000580-dcid9emx 213 73 , , , cord-000580-dcid9emx 213 74 an an DT cord-000580-dcid9emx 213 75 adipocyte adipocyte NN cord-000580-dcid9emx 213 76 gene gene NN cord-000580-dcid9emx 213 77 co co NNS cord-000580-dcid9emx 213 78 - - VBN cord-000580-dcid9emx 213 79 expressed express VBN cord-000580-dcid9emx 213 80 in in IN cord-000580-dcid9emx 213 81 peripheral peripheral JJ cord-000580-dcid9emx 213 82 neurons neuron NNS cord-000580-dcid9emx 213 83 Molecular Molecular NNP cord-000580-dcid9emx 213 84 Characterization characterization NN cord-000580-dcid9emx 213 85 of of IN cord-000580-dcid9emx 213 86 the the DT cord-000580-dcid9emx 213 87 Tumor Tumor NNP cord-000580-dcid9emx 213 88 Suppressor Suppressor NNP cord-000580-dcid9emx 213 89 Candidate Candidate NNP cord-000580-dcid9emx 213 90 5 5 CD cord-000580-dcid9emx 213 91 Gene gene NN cord-000580-dcid9emx 213 92 : : : cord-000580-dcid9emx 213 93 Regulation regulation NN cord-000580-dcid9emx 213 94 by by IN cord-000580-dcid9emx 213 95 PPARgamma PPARgamma NNP cord-000580-dcid9emx 213 96 and and CC cord-000580-dcid9emx 213 97 Identification Identification NNP cord-000580-dcid9emx 213 98 of of IN cord-000580-dcid9emx 213 99 TUSC5 TUSC5 NNP cord-000580-dcid9emx 213 100 Coding Coding NNP cord-000580-dcid9emx 213 101 Variants Variants NNPS cord-000580-dcid9emx 213 102 in in IN cord-000580-dcid9emx 213 103 Lean lean JJ cord-000580-dcid9emx 213 104 and and CC cord-000580-dcid9emx 213 105 Obese obese JJ cord-000580-dcid9emx 213 106 Humans human NNS cord-000580-dcid9emx 214 1 Concerted concerted JJ cord-000580-dcid9emx 214 2 evolution evolution NN cord-000580-dcid9emx 214 3 : : : cord-000580-dcid9emx 215 1 molecular molecular JJ cord-000580-dcid9emx 215 2 mechanism mechanism NN cord-000580-dcid9emx 215 3 and and CC cord-000580-dcid9emx 215 4 biological biological JJ cord-000580-dcid9emx 215 5 implications implication NNS cord-000580-dcid9emx 215 6 Transcriptional Transcriptional NNP cord-000580-dcid9emx 215 7 profiling profiling NN cord-000580-dcid9emx 215 8 of of IN cord-000580-dcid9emx 215 9 the the DT cord-000580-dcid9emx 215 10 human human JJ cord-000580-dcid9emx 215 11 monocyte monocyte NNP cord-000580-dcid9emx 215 12 - - HYPH cord-000580-dcid9emx 215 13 to to IN cord-000580-dcid9emx 215 14 - - HYPH cord-000580-dcid9emx 215 15 macrophage macrophage NN cord-000580-dcid9emx 215 16 differentiation differentiation NN cord-000580-dcid9emx 215 17 and and CC cord-000580-dcid9emx 215 18 polarization polarization NN cord-000580-dcid9emx 215 19 : : : cord-000580-dcid9emx 215 20 new new JJ cord-000580-dcid9emx 215 21 molecules molecule NNS cord-000580-dcid9emx 215 22 and and CC cord-000580-dcid9emx 215 23 patterns pattern NNS cord-000580-dcid9emx 215 24 of of IN cord-000580-dcid9emx 215 25 gene gene NN cord-000580-dcid9emx 215 26 expression expression NN cord-000580-dcid9emx 215 27 Normal normal JJ cord-000580-dcid9emx 215 28 germ germ NN cord-000580-dcid9emx 215 29 line line NN cord-000580-dcid9emx 215 30 establishment establishment NN cord-000580-dcid9emx 215 31 in in IN cord-000580-dcid9emx 215 32 mice mouse NNS cord-000580-dcid9emx 215 33 carrying carry VBG cord-000580-dcid9emx 215 34 a a DT cord-000580-dcid9emx 215 35 deletion deletion NN cord-000580-dcid9emx 215 36 of of IN cord-000580-dcid9emx 215 37 the the DT cord-000580-dcid9emx 215 38 Ifitm Ifitm NNP cord-000580-dcid9emx 215 39 / / SYM cord-000580-dcid9emx 215 40 Fragilis Fragilis NNP cord-000580-dcid9emx 215 41 gene gene NN cord-000580-dcid9emx 215 42 family family NN cord-000580-dcid9emx 215 43 cluster cluster NN cord-000580-dcid9emx 215 44 Palmitoylome Palmitoylome NNP cord-000580-dcid9emx 215 45 profiling profiling NN cord-000580-dcid9emx 215 46 reveals reveal VBZ cord-000580-dcid9emx 215 47 S s NN cord-000580-dcid9emx 215 48 - - HYPH cord-000580-dcid9emx 215 49 palmitoylation palmitoylation NN cord-000580-dcid9emx 215 50 - - HYPH cord-000580-dcid9emx 215 51 dependent dependent JJ cord-000580-dcid9emx 215 52 antiviral antiviral JJ cord-000580-dcid9emx 215 53 activity activity NN cord-000580-dcid9emx 215 54 of of IN cord-000580-dcid9emx 215 55 IFITM3 IFITM3 NNP cord-000580-dcid9emx 216 1 The the DT cord-000580-dcid9emx 216 2 Pfam Pfam NNP cord-000580-dcid9emx 216 3 protein protein NN cord-000580-dcid9emx 216 4 families family NNS cord-000580-dcid9emx 216 5 database database VBP cord-000580-dcid9emx 216 6 A a DT cord-000580-dcid9emx 216 7 new new JJ cord-000580-dcid9emx 216 8 generation generation NN cord-000580-dcid9emx 216 9 of of IN cord-000580-dcid9emx 216 10 homology homology NN cord-000580-dcid9emx 216 11 search search NN cord-000580-dcid9emx 216 12 tools tool NNS cord-000580-dcid9emx 216 13 based base VBN cord-000580-dcid9emx 216 14 on on IN cord-000580-dcid9emx 216 15 probabilistic probabilistic JJ cord-000580-dcid9emx 216 16 inference inference NN cord-000580-dcid9emx 217 1 Recent recent JJ cord-000580-dcid9emx 217 2 developments development NNS cord-000580-dcid9emx 217 3 in in IN cord-000580-dcid9emx 217 4 the the DT cord-000580-dcid9emx 217 5 MAFFT MAFFT NNP cord-000580-dcid9emx 217 6 multiple multiple JJ cord-000580-dcid9emx 217 7 sequence sequence NN cord-000580-dcid9emx 217 8 alignment alignment NN cord-000580-dcid9emx 217 9 program program NN cord-000580-dcid9emx 217 10 Jalview Jalview NNP cord-000580-dcid9emx 217 11 Version Version NNP cord-000580-dcid9emx 217 12 2-a 2-a CD cord-000580-dcid9emx 217 13 multiple multiple JJ cord-000580-dcid9emx 217 14 sequence sequence NN cord-000580-dcid9emx 217 15 alignment alignment NN cord-000580-dcid9emx 217 16 editor editor NN cord-000580-dcid9emx 217 17 and and CC cord-000580-dcid9emx 218 1 analysis analysis NN cord-000580-dcid9emx 218 2 workbench workbench NNP cord-000580-dcid9emx 218 3 MRBAYES MRBAYES NNP cord-000580-dcid9emx 218 4 : : : cord-000580-dcid9emx 219 1 Bayesian bayesian JJ cord-000580-dcid9emx 219 2 inference inference NN cord-000580-dcid9emx 219 3 of of IN cord-000580-dcid9emx 219 4 phylogenetic phylogenetic JJ cord-000580-dcid9emx 219 5 trees tree NNS cord-000580-dcid9emx 219 6 RAxML RAxML VBZ cord-000580-dcid9emx 219 7 - - HYPH cord-000580-dcid9emx 219 8 VI vi NN cord-000580-dcid9emx 219 9 - - HYPH cord-000580-dcid9emx 219 10 HPC HPC NNP cord-000580-dcid9emx 219 11 : : : cord-000580-dcid9emx 219 12 maximum maximum JJ cord-000580-dcid9emx 219 13 likelihood likelihood NN cord-000580-dcid9emx 219 14 - - HYPH cord-000580-dcid9emx 219 15 based base VBN cord-000580-dcid9emx 219 16 phylogenetic phylogenetic NN cord-000580-dcid9emx 219 17 analyses analysis NNS cord-000580-dcid9emx 219 18 with with IN cord-000580-dcid9emx 219 19 thousands thousand NNS cord-000580-dcid9emx 219 20 of of IN cord-000580-dcid9emx 219 21 taxa taxon NNS cord-000580-dcid9emx 219 22 and and CC cord-000580-dcid9emx 219 23 mixed mixed JJ cord-000580-dcid9emx 219 24 models model NNS cord-000580-dcid9emx 220 1 Dendroscope dendroscope NN cord-000580-dcid9emx 220 2 : : : cord-000580-dcid9emx 221 1 An an DT cord-000580-dcid9emx 221 2 interactive interactive JJ cord-000580-dcid9emx 221 3 viewer viewer NN cord-000580-dcid9emx 221 4 for for IN cord-000580-dcid9emx 221 5 large large JJ cord-000580-dcid9emx 221 6 phylogenetic phylogenetic JJ cord-000580-dcid9emx 221 7 trees tree NNS cord-000580-dcid9emx 221 8 Sequence sequence NN cord-000580-dcid9emx 221 9 and and CC cord-000580-dcid9emx 221 10 structure structure NN cord-000580-dcid9emx 221 11 - - HYPH cord-000580-dcid9emx 221 12 based base VBN cord-000580-dcid9emx 221 13 prediction prediction NN cord-000580-dcid9emx 221 14 of of IN cord-000580-dcid9emx 221 15 eukaryotic eukaryotic JJ cord-000580-dcid9emx 221 16 protein protein NN cord-000580-dcid9emx 221 17 phosphorylation phosphorylation NN cord-000580-dcid9emx 221 18 sites site NNS cord-000580-dcid9emx 221 19 Prediction prediction NN cord-000580-dcid9emx 221 20 , , , cord-000580-dcid9emx 221 21 conservation conservation NN cord-000580-dcid9emx 221 22 analysis analysis NN cord-000580-dcid9emx 221 23 , , , cord-000580-dcid9emx 221 24 and and CC cord-000580-dcid9emx 221 25 structural structural JJ cord-000580-dcid9emx 221 26 characterization characterization NN cord-000580-dcid9emx 221 27 of of IN cord-000580-dcid9emx 221 28 mammalian mammalian JJ cord-000580-dcid9emx 221 29 mucin mucin NN cord-000580-dcid9emx 221 30 - - HYPH cord-000580-dcid9emx 221 31 type type NN cord-000580-dcid9emx 221 32 Oglycosylation oglycosylation NN cord-000580-dcid9emx 221 33 sites site NNS cord-000580-dcid9emx 222 1 A a DT cord-000580-dcid9emx 222 2 hidden hidden JJ cord-000580-dcid9emx 222 3 Markov Markov NNP cord-000580-dcid9emx 222 4 model model NN cord-000580-dcid9emx 222 5 for for IN cord-000580-dcid9emx 222 6 predicting predict VBG cord-000580-dcid9emx 222 7 transmembrane transmembrane NNP cord-000580-dcid9emx 222 8 helices helix NNS cord-000580-dcid9emx 222 9 in in IN cord-000580-dcid9emx 222 10 protein protein NN cord-000580-dcid9emx 222 11 sequences sequence NNS