id	sid	tid	token	lemma	pos
cord-000248-zueoyesj	1	1	key	key	JJ
cord-000248-zueoyesj	1	2	:	:	:
cord-000248-zueoyesj	1	3	cord-000248-zueoyesj	cord-000248-zueoyesj	.
cord-000248-zueoyesj	2	1	authors	author	NNS
cord-000248-zueoyesj	2	2	:	:	:
cord-000248-zueoyesj	2	3	Berretta	Berretta	NNP
cord-000248-zueoyesj	2	4	,	,	,
cord-000248-zueoyesj	2	5	Regina	Regina	NNP
cord-000248-zueoyesj	2	6	;	;	:
cord-000248-zueoyesj	2	7	Moscato	Moscato	NNP
cord-000248-zueoyesj	2	8	,	,	,
cord-000248-zueoyesj	2	9	Pablo	Pablo	NNP
cord-000248-zueoyesj	2	10	title	title	NN
cord-000248-zueoyesj	2	11	:	:	:
cord-000248-zueoyesj	2	12	Cancer	Cancer	NNP
cord-000248-zueoyesj	2	13	Biomarker	Biomarker	NNP
cord-000248-zueoyesj	2	14	Discovery	Discovery	NNP
cord-000248-zueoyesj	2	15	:	:	:
cord-000248-zueoyesj	3	1	The	the	DT
cord-000248-zueoyesj	3	2	Entropic	entropic	JJ
cord-000248-zueoyesj	3	3	Hallmark	Hallmark	NNP
cord-000248-zueoyesj	3	4	date	date	NN
cord-000248-zueoyesj	3	5	:	:	:
cord-000248-zueoyesj	3	6	2010	2010	CD
cord-000248-zueoyesj	3	7	-	-	SYM
cord-000248-zueoyesj	3	8	08	08	CD
cord-000248-zueoyesj	3	9	-	-	SYM
cord-000248-zueoyesj	3	10	18	18	CD
cord-000248-zueoyesj	3	11	journal	journal	NN
cord-000248-zueoyesj	3	12	:	:	:
cord-000248-zueoyesj	4	1	PLoS	PLoS	NNP
cord-000248-zueoyesj	5	1	One	one	CD
cord-000248-zueoyesj	5	2	DOI	doi	NN
cord-000248-zueoyesj	5	3	:	:	:
cord-000248-zueoyesj	6	1	10.1371	10.1371	CD
cord-000248-zueoyesj	6	2	/	/	SYM
cord-000248-zueoyesj	6	3	journal.pone.0012262	journal.pone.0012262	NNP
cord-000248-zueoyesj	6	4	sha	sha	NNP
cord-000248-zueoyesj	6	5	:	:	:
cord-000248-zueoyesj	7	1	ab371ed38caa53c720fd4c0333e1bf4de84550f1	ab371ed38caa53c720fd4c0333e1bf4de84550f1	NNP
cord-000248-zueoyesj	7	2	doc_id	doc_id	CD
cord-000248-zueoyesj	7	3	:	:	:
cord-000248-zueoyesj	7	4	248	248	CD
cord-000248-zueoyesj	7	5	cord_uid	cord_uid	NNS
cord-000248-zueoyesj	7	6	:	:	:
cord-000248-zueoyesj	8	1	zueoyesj	zueoyesj	NNP
cord-000248-zueoyesj	8	2	BACKGROUND	BACKGROUND	NNP
cord-000248-zueoyesj	8	3	:	:	:
cord-000248-zueoyesj	9	1	It	-PRON-	PRP
cord-000248-zueoyesj	9	2	is	be	VBZ
cord-000248-zueoyesj	9	3	a	a	DT
cord-000248-zueoyesj	9	4	commonly	commonly	RB
cord-000248-zueoyesj	9	5	accepted	accept	VBN
cord-000248-zueoyesj	9	6	belief	belief	NN
cord-000248-zueoyesj	9	7	that	that	IN
cord-000248-zueoyesj	9	8	cancer	cancer	NN
cord-000248-zueoyesj	9	9	cells	cell	NNS
cord-000248-zueoyesj	9	10	modify	modify	VBP
cord-000248-zueoyesj	9	11	their	-PRON-	PRP$
cord-000248-zueoyesj	9	12	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	9	13	state	state	NN
cord-000248-zueoyesj	9	14	during	during	IN
cord-000248-zueoyesj	9	15	the	the	DT
cord-000248-zueoyesj	9	16	progression	progression	NN
cord-000248-zueoyesj	9	17	of	of	IN
cord-000248-zueoyesj	9	18	the	the	DT
cord-000248-zueoyesj	9	19	disease	disease	NN
cord-000248-zueoyesj	9	20	.	.	.
cord-000248-zueoyesj	10	1	We	-PRON-	PRP
cord-000248-zueoyesj	10	2	propose	propose	VBP
cord-000248-zueoyesj	10	3	that	that	IN
cord-000248-zueoyesj	10	4	the	the	DT
cord-000248-zueoyesj	10	5	progression	progression	NN
cord-000248-zueoyesj	10	6	of	of	IN
cord-000248-zueoyesj	10	7	cancer	cancer	NN
cord-000248-zueoyesj	10	8	cells	cell	NNS
cord-000248-zueoyesj	10	9	towards	towards	IN
cord-000248-zueoyesj	10	10	malignant	malignant	JJ
cord-000248-zueoyesj	10	11	phenotypes	phenotype	NNS
cord-000248-zueoyesj	10	12	can	can	MD
cord-000248-zueoyesj	10	13	be	be	VB
cord-000248-zueoyesj	10	14	efficiently	efficiently	RB
cord-000248-zueoyesj	10	15	tracked	track	VBN
cord-000248-zueoyesj	10	16	using	use	VBG
cord-000248-zueoyesj	10	17	high	high	JJ
cord-000248-zueoyesj	10	18	-	-	HYPH
cord-000248-zueoyesj	10	19	throughput	throughput	NN
cord-000248-zueoyesj	10	20	technologies	technology	NNS
cord-000248-zueoyesj	10	21	that	that	WDT
cord-000248-zueoyesj	10	22	follow	follow	VBP
cord-000248-zueoyesj	10	23	the	the	DT
cord-000248-zueoyesj	10	24	gradual	gradual	JJ
cord-000248-zueoyesj	10	25	changes	change	NNS
cord-000248-zueoyesj	10	26	observed	observe	VBN
cord-000248-zueoyesj	10	27	in	in	IN
cord-000248-zueoyesj	10	28	the	the	DT
cord-000248-zueoyesj	10	29	gene	gene	NN
cord-000248-zueoyesj	10	30	expression	expression	NN
cord-000248-zueoyesj	10	31	profiles	profile	NNS
cord-000248-zueoyesj	10	32	by	by	IN
cord-000248-zueoyesj	10	33	employing	employ	VBG
cord-000248-zueoyesj	10	34	Shannon	Shannon	NNP
cord-000248-zueoyesj	10	35	's	's	POS
cord-000248-zueoyesj	10	36	mathematical	mathematical	JJ
cord-000248-zueoyesj	10	37	theory	theory	NN
cord-000248-zueoyesj	10	38	of	of	IN
cord-000248-zueoyesj	10	39	communication	communication	NN
cord-000248-zueoyesj	10	40	.	.	.
cord-000248-zueoyesj	11	1	Methods	method	NNS
cord-000248-zueoyesj	11	2	based	base	VBN
cord-000248-zueoyesj	11	3	on	on	IN
cord-000248-zueoyesj	11	4	Information	Information	NNP
cord-000248-zueoyesj	11	5	Theory	Theory	NNP
cord-000248-zueoyesj	11	6	can	can	MD
cord-000248-zueoyesj	11	7	then	then	RB
cord-000248-zueoyesj	11	8	quantify	quantify	VB
cord-000248-zueoyesj	11	9	the	the	DT
cord-000248-zueoyesj	11	10	divergence	divergence	NN
cord-000248-zueoyesj	11	11	of	of	IN
cord-000248-zueoyesj	11	12	cancer	cancer	NN
cord-000248-zueoyesj	11	13	cells	cell	NNS
cord-000248-zueoyesj	11	14	'	'	POS
cord-000248-zueoyesj	11	15	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	11	16	profiles	profile	NNS
cord-000248-zueoyesj	11	17	from	from	IN
cord-000248-zueoyesj	11	18	those	those	DT
cord-000248-zueoyesj	11	19	of	of	IN
cord-000248-zueoyesj	11	20	normally	normally	RB
cord-000248-zueoyesj	11	21	appearing	appear	VBG
cord-000248-zueoyesj	11	22	cells	cell	NNS
cord-000248-zueoyesj	11	23	of	of	IN
cord-000248-zueoyesj	11	24	the	the	DT
cord-000248-zueoyesj	11	25	originating	originate	VBG
cord-000248-zueoyesj	11	26	tissues	tissue	NNS
cord-000248-zueoyesj	11	27	.	.	.
cord-000248-zueoyesj	12	1	The	the	DT
cord-000248-zueoyesj	12	2	relevance	relevance	NN
cord-000248-zueoyesj	12	3	of	of	IN
cord-000248-zueoyesj	12	4	the	the	DT
cord-000248-zueoyesj	12	5	proposed	propose	VBN
cord-000248-zueoyesj	12	6	methods	method	NNS
cord-000248-zueoyesj	12	7	can	can	MD
cord-000248-zueoyesj	12	8	be	be	VB
cord-000248-zueoyesj	12	9	evaluated	evaluate	VBN
cord-000248-zueoyesj	12	10	using	use	VBG
cord-000248-zueoyesj	12	11	microarray	microarray	NN
cord-000248-zueoyesj	12	12	datasets	dataset	NNS
cord-000248-zueoyesj	12	13	available	available	JJ
cord-000248-zueoyesj	12	14	in	in	IN
cord-000248-zueoyesj	12	15	the	the	DT
cord-000248-zueoyesj	12	16	public	public	JJ
cord-000248-zueoyesj	12	17	domain	domain	NN
cord-000248-zueoyesj	12	18	but	but	CC
cord-000248-zueoyesj	12	19	the	the	DT
cord-000248-zueoyesj	12	20	method	method	NN
cord-000248-zueoyesj	12	21	is	be	VBZ
cord-000248-zueoyesj	12	22	in	in	IN
cord-000248-zueoyesj	12	23	principle	principle	NN
cord-000248-zueoyesj	12	24	applicable	applicable	JJ
cord-000248-zueoyesj	12	25	to	to	IN
cord-000248-zueoyesj	12	26	other	other	JJ
cord-000248-zueoyesj	12	27	high	high	JJ
cord-000248-zueoyesj	12	28	-	-	HYPH
cord-000248-zueoyesj	12	29	throughput	throughput	NN
cord-000248-zueoyesj	12	30	methods	method	NNS
cord-000248-zueoyesj	12	31	.	.	.
cord-000248-zueoyesj	13	1	METHODOLOGY	methodology	NN
cord-000248-zueoyesj	13	2	/	/	SYM
cord-000248-zueoyesj	13	3	PRINCIPAL	principal	NN
cord-000248-zueoyesj	13	4	FINDINGS	finding	NNS
cord-000248-zueoyesj	13	5	:	:	:
cord-000248-zueoyesj	14	1	Using	use	VBG
cord-000248-zueoyesj	14	2	melanoma	melanoma	NN
cord-000248-zueoyesj	14	3	and	and	CC
cord-000248-zueoyesj	14	4	prostate	prostate	NN
cord-000248-zueoyesj	14	5	cancer	cancer	NN
cord-000248-zueoyesj	14	6	datasets	dataset	NNS
cord-000248-zueoyesj	14	7	we	-PRON-	PRP
cord-000248-zueoyesj	14	8	illustrate	illustrate	VBP
cord-000248-zueoyesj	14	9	how	how	WRB
cord-000248-zueoyesj	14	10	it	-PRON-	PRP
cord-000248-zueoyesj	14	11	is	be	VBZ
cord-000248-zueoyesj	14	12	possible	possible	JJ
cord-000248-zueoyesj	14	13	to	to	TO
cord-000248-zueoyesj	14	14	employ	employ	VB
cord-000248-zueoyesj	14	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	14	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	14	17	and	and	CC
cord-000248-zueoyesj	14	18	the	the	DT
cord-000248-zueoyesj	14	19	Jensen	Jensen	NNP
cord-000248-zueoyesj	14	20	-	-	HYPH
cord-000248-zueoyesj	14	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	14	22	divergence	divergence	NN
cord-000248-zueoyesj	14	23	to	to	TO
cord-000248-zueoyesj	14	24	trace	trace	VB
cord-000248-zueoyesj	14	25	the	the	DT
cord-000248-zueoyesj	14	26	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	14	27	changes	change	NNS
cord-000248-zueoyesj	14	28	progression	progression	NN
cord-000248-zueoyesj	14	29	of	of	IN
cord-000248-zueoyesj	14	30	the	the	DT
cord-000248-zueoyesj	14	31	disease	disease	NN
cord-000248-zueoyesj	14	32	.	.	.
cord-000248-zueoyesj	15	1	We	-PRON-	PRP
cord-000248-zueoyesj	15	2	establish	establish	VBP
cord-000248-zueoyesj	15	3	how	how	WRB
cord-000248-zueoyesj	15	4	the	the	DT
cord-000248-zueoyesj	15	5	variations	variation	NNS
cord-000248-zueoyesj	15	6	of	of	IN
cord-000248-zueoyesj	15	7	these	these	DT
cord-000248-zueoyesj	15	8	two	two	CD
cord-000248-zueoyesj	15	9	measures	measure	NNS
cord-000248-zueoyesj	15	10	correlate	correlate	VBP
cord-000248-zueoyesj	15	11	with	with	IN
cord-000248-zueoyesj	15	12	established	establish	VBN
cord-000248-zueoyesj	15	13	biomarkers	biomarker	NNS
cord-000248-zueoyesj	15	14	of	of	IN
cord-000248-zueoyesj	15	15	cancer	cancer	NN
cord-000248-zueoyesj	15	16	progression	progression	NN
cord-000248-zueoyesj	15	17	.	.	.
cord-000248-zueoyesj	16	1	The	the	DT
cord-000248-zueoyesj	16	2	Information	Information	NNP
cord-000248-zueoyesj	16	3	Theory	Theory	NNP
cord-000248-zueoyesj	16	4	measures	measure	NNS
cord-000248-zueoyesj	16	5	allow	allow	VBP
cord-000248-zueoyesj	16	6	us	-PRON-	PRP
cord-000248-zueoyesj	16	7	to	to	TO
cord-000248-zueoyesj	16	8	identify	identify	VB
cord-000248-zueoyesj	16	9	novel	novel	JJ
cord-000248-zueoyesj	16	10	biomarkers	biomarker	NNS
cord-000248-zueoyesj	16	11	for	for	IN
cord-000248-zueoyesj	16	12	both	both	CC
cord-000248-zueoyesj	16	13	progressive	progressive	JJ
cord-000248-zueoyesj	16	14	and	and	CC
cord-000248-zueoyesj	16	15	relatively	relatively	RB
cord-000248-zueoyesj	16	16	more	more	RBR
cord-000248-zueoyesj	16	17	sudden	sudden	JJ
cord-000248-zueoyesj	16	18	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	16	19	changes	change	NNS
cord-000248-zueoyesj	16	20	leading	lead	VBG
cord-000248-zueoyesj	16	21	to	to	IN
cord-000248-zueoyesj	16	22	malignant	malignant	JJ
cord-000248-zueoyesj	16	23	phenotypes	phenotype	NNS
cord-000248-zueoyesj	16	24	.	.	.
cord-000248-zueoyesj	17	1	At	at	IN
cord-000248-zueoyesj	17	2	the	the	DT
cord-000248-zueoyesj	17	3	same	same	JJ
cord-000248-zueoyesj	17	4	time	time	NN
cord-000248-zueoyesj	17	5	,	,	,
cord-000248-zueoyesj	17	6	the	the	DT
cord-000248-zueoyesj	17	7	methodology	methodology	NN
cord-000248-zueoyesj	17	8	was	be	VBD
cord-000248-zueoyesj	17	9	able	able	JJ
cord-000248-zueoyesj	17	10	to	to	TO
cord-000248-zueoyesj	17	11	validate	validate	VB
cord-000248-zueoyesj	17	12	a	a	DT
cord-000248-zueoyesj	17	13	large	large	JJ
cord-000248-zueoyesj	17	14	number	number	NN
cord-000248-zueoyesj	17	15	of	of	IN
cord-000248-zueoyesj	17	16	genes	gene	NNS
cord-000248-zueoyesj	17	17	and	and	CC
cord-000248-zueoyesj	17	18	processes	process	NNS
cord-000248-zueoyesj	17	19	that	that	WDT
cord-000248-zueoyesj	17	20	seem	seem	VBP
cord-000248-zueoyesj	17	21	to	to	TO
cord-000248-zueoyesj	17	22	be	be	VB
cord-000248-zueoyesj	17	23	implicated	implicate	VBN
cord-000248-zueoyesj	17	24	in	in	IN
cord-000248-zueoyesj	17	25	the	the	DT
cord-000248-zueoyesj	17	26	progression	progression	NN
cord-000248-zueoyesj	17	27	of	of	IN
cord-000248-zueoyesj	17	28	melanoma	melanoma	NN
cord-000248-zueoyesj	17	29	and	and	CC
cord-000248-zueoyesj	17	30	prostate	prostate	NN
cord-000248-zueoyesj	17	31	cancer	cancer	NN
cord-000248-zueoyesj	17	32	.	.	.
cord-000248-zueoyesj	18	1	CONCLUSIONS	conclusion	NNS
cord-000248-zueoyesj	18	2	/	/	SYM
cord-000248-zueoyesj	18	3	SIGNIFICANCE	significance	NN
cord-000248-zueoyesj	18	4	:	:	:
cord-000248-zueoyesj	19	1	We	-PRON-	PRP
cord-000248-zueoyesj	19	2	thus	thus	RB
cord-000248-zueoyesj	19	3	present	present	VBP
cord-000248-zueoyesj	19	4	a	a	DT
cord-000248-zueoyesj	19	5	quantitative	quantitative	JJ
cord-000248-zueoyesj	19	6	guiding	guiding	NN
cord-000248-zueoyesj	19	7	rule	rule	NN
cord-000248-zueoyesj	19	8	,	,	,
cord-000248-zueoyesj	19	9	a	a	DT
cord-000248-zueoyesj	19	10	new	new	JJ
cord-000248-zueoyesj	19	11	unifying	unify	VBG
cord-000248-zueoyesj	19	12	hallmark	hallmark	NN
cord-000248-zueoyesj	19	13	of	of	IN
cord-000248-zueoyesj	19	14	cancer	cancer	NN
cord-000248-zueoyesj	19	15	:	:	:
cord-000248-zueoyesj	19	16	the	the	DT
cord-000248-zueoyesj	19	17	cancer	cancer	NN
cord-000248-zueoyesj	19	18	cell	cell	NN
cord-000248-zueoyesj	19	19	's	's	POS
cord-000248-zueoyesj	19	20	transcriptome	transcriptome	NN
cord-000248-zueoyesj	19	21	changes	change	NNS
cord-000248-zueoyesj	19	22	lead	lead	VBP
cord-000248-zueoyesj	19	23	to	to	IN
cord-000248-zueoyesj	19	24	measurable	measurable	JJ
cord-000248-zueoyesj	19	25	observed	observed	JJ
cord-000248-zueoyesj	19	26	transitions	transition	NNS
cord-000248-zueoyesj	19	27	of	of	IN
cord-000248-zueoyesj	19	28	Normalized	Normalized	NNP
cord-000248-zueoyesj	19	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	19	30	Entropy	Entropy	NNP
cord-000248-zueoyesj	19	31	values	value	NNS
cord-000248-zueoyesj	19	32	(	(	-LRB-
cord-000248-zueoyesj	19	33	as	as	IN
cord-000248-zueoyesj	19	34	measured	measure	VBN
cord-000248-zueoyesj	19	35	by	by	IN
cord-000248-zueoyesj	19	36	high	high	JJ
cord-000248-zueoyesj	19	37	-	-	HYPH
cord-000248-zueoyesj	19	38	througput	througput	NN
cord-000248-zueoyesj	19	39	technologies	technology	NNS
cord-000248-zueoyesj	19	40	)	)	-RRB-
cord-000248-zueoyesj	19	41	.	.	.
cord-000248-zueoyesj	20	1	At	at	IN
cord-000248-zueoyesj	20	2	the	the	DT
cord-000248-zueoyesj	20	3	same	same	JJ
cord-000248-zueoyesj	20	4	time	time	NN
cord-000248-zueoyesj	20	5	,	,	,
cord-000248-zueoyesj	20	6	tumor	tumor	NN
cord-000248-zueoyesj	20	7	cells	cell	NNS
cord-000248-zueoyesj	20	8	increment	increment	VBP
cord-000248-zueoyesj	20	9	their	-PRON-	PRP$
cord-000248-zueoyesj	20	10	divergence	divergence	NN
cord-000248-zueoyesj	20	11	from	from	IN
cord-000248-zueoyesj	20	12	the	the	DT
cord-000248-zueoyesj	20	13	normal	normal	JJ
cord-000248-zueoyesj	20	14	tissue	tissue	NN
cord-000248-zueoyesj	20	15	profile	profile	NN
cord-000248-zueoyesj	20	16	increasing	increase	VBG
cord-000248-zueoyesj	20	17	their	-PRON-	PRP$
cord-000248-zueoyesj	20	18	disorder	disorder	NN
cord-000248-zueoyesj	20	19	via	via	IN
cord-000248-zueoyesj	20	20	creation	creation	NN
cord-000248-zueoyesj	20	21	of	of	IN
cord-000248-zueoyesj	20	22	states	state	NNS
cord-000248-zueoyesj	20	23	that	that	IN
cord-000248-zueoyesj	20	24	we	-PRON-	PRP
cord-000248-zueoyesj	20	25	might	may	MD
cord-000248-zueoyesj	20	26	not	not	RB
cord-000248-zueoyesj	20	27	directly	directly	RB
cord-000248-zueoyesj	20	28	measure	measure	VB
cord-000248-zueoyesj	20	29	.	.	.
cord-000248-zueoyesj	21	1	This	this	DT
cord-000248-zueoyesj	21	2	unifying	unify	VBG
cord-000248-zueoyesj	21	3	hallmark	hallmark	NN
cord-000248-zueoyesj	21	4	allows	allow	VBZ
cord-000248-zueoyesj	21	5	,	,	,
cord-000248-zueoyesj	21	6	via	via	IN
cord-000248-zueoyesj	21	7	the	the	DT
cord-000248-zueoyesj	21	8	the	the	DT
cord-000248-zueoyesj	21	9	Jensen	Jensen	NNP
cord-000248-zueoyesj	21	10	-	-	HYPH
cord-000248-zueoyesj	21	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	21	12	divergence	divergence	NN
cord-000248-zueoyesj	21	13	,	,	,
cord-000248-zueoyesj	21	14	to	to	TO
cord-000248-zueoyesj	21	15	identify	identify	VB
cord-000248-zueoyesj	21	16	the	the	DT
cord-000248-zueoyesj	21	17	arrow	arrow	NN
cord-000248-zueoyesj	21	18	of	of	IN
cord-000248-zueoyesj	21	19	time	time	NN
cord-000248-zueoyesj	21	20	of	of	IN
cord-000248-zueoyesj	21	21	the	the	DT
cord-000248-zueoyesj	21	22	processes	process	NNS
cord-000248-zueoyesj	21	23	from	from	IN
cord-000248-zueoyesj	21	24	the	the	DT
cord-000248-zueoyesj	21	25	gene	gene	NN
cord-000248-zueoyesj	21	26	expression	expression	NN
cord-000248-zueoyesj	21	27	profiles	profile	NNS
cord-000248-zueoyesj	21	28	,	,	,
cord-000248-zueoyesj	21	29	and	and	CC
cord-000248-zueoyesj	21	30	helps	help	VBZ
cord-000248-zueoyesj	21	31	to	to	TO
cord-000248-zueoyesj	21	32	map	map	VB
cord-000248-zueoyesj	21	33	the	the	DT
cord-000248-zueoyesj	21	34	phenotypical	phenotypical	JJ
cord-000248-zueoyesj	21	35	and	and	CC
cord-000248-zueoyesj	21	36	molecular	molecular	JJ
cord-000248-zueoyesj	21	37	hallmarks	hallmark	NNS
cord-000248-zueoyesj	21	38	of	of	IN
cord-000248-zueoyesj	21	39	specific	specific	JJ
cord-000248-zueoyesj	21	40	cancer	cancer	NN
cord-000248-zueoyesj	21	41	subtypes	subtype	NNS
cord-000248-zueoyesj	21	42	.	.	.
cord-000248-zueoyesj	22	1	The	the	DT
cord-000248-zueoyesj	22	2	deep	deep	JJ
cord-000248-zueoyesj	22	3	mathematical	mathematical	JJ
cord-000248-zueoyesj	22	4	basis	basis	NN
cord-000248-zueoyesj	22	5	of	of	IN
cord-000248-zueoyesj	22	6	the	the	DT
cord-000248-zueoyesj	22	7	approach	approach	NN
cord-000248-zueoyesj	22	8	allows	allow	VBZ
cord-000248-zueoyesj	22	9	us	-PRON-	PRP
cord-000248-zueoyesj	22	10	to	to	TO
cord-000248-zueoyesj	22	11	suggest	suggest	VB
cord-000248-zueoyesj	22	12	that	that	IN
cord-000248-zueoyesj	22	13	this	this	DT
cord-000248-zueoyesj	22	14	principle	principle	NN
cord-000248-zueoyesj	22	15	is	be	VBZ
cord-000248-zueoyesj	22	16	,	,	,
cord-000248-zueoyesj	22	17	hopefully	hopefully	RB
cord-000248-zueoyesj	22	18	,	,	,
cord-000248-zueoyesj	22	19	of	of	IN
cord-000248-zueoyesj	22	20	general	general	JJ
cord-000248-zueoyesj	22	21	applicability	applicability	NN
cord-000248-zueoyesj	22	22	for	for	IN
cord-000248-zueoyesj	22	23	other	other	JJ
cord-000248-zueoyesj	22	24	diseases	disease	NNS
cord-000248-zueoyesj	22	25	.	.	.
cord-000248-zueoyesj	23	1	In	in	IN
cord-000248-zueoyesj	23	2	a	a	DT
cord-000248-zueoyesj	23	3	seminal	seminal	JJ
cord-000248-zueoyesj	23	4	review	review	NN
cord-000248-zueoyesj	23	5	paper	paper	NN
cord-000248-zueoyesj	23	6	published	publish	VBD
cord-000248-zueoyesj	23	7	nine	nine	CD
cord-000248-zueoyesj	23	8	years	year	NNS
cord-000248-zueoyesj	23	9	ago	ago	RB
cord-000248-zueoyesj	23	10	,	,	,
cord-000248-zueoyesj	23	11	Hanahan	Hanahan	NNP
cord-000248-zueoyesj	23	12	and	and	CC
cord-000248-zueoyesj	23	13	Weinberg	Weinberg	NNP
cord-000248-zueoyesj	23	14	[	[	-LRB-
cord-000248-zueoyesj	23	15	1	1	CD
cord-000248-zueoyesj	23	16	]	]	-RRB-
cord-000248-zueoyesj	23	17	introduced	introduce	VBD
cord-000248-zueoyesj	23	18	the	the	DT
cord-000248-zueoyesj	23	19	'	'	``
cord-000248-zueoyesj	23	20	'	'	``
cord-000248-zueoyesj	23	21	hallmarks	hallmark	NNS
cord-000248-zueoyesj	23	22	of	of	IN
cord-000248-zueoyesj	23	23	cancer	cancer	NN
cord-000248-zueoyesj	23	24	'	'	''
cord-000248-zueoyesj	23	25	'	'	''
cord-000248-zueoyesj	23	26	.	.	.
cord-000248-zueoyesj	24	1	They	-PRON-	PRP
cord-000248-zueoyesj	24	2	are	be	VBP
cord-000248-zueoyesj	24	3	six	six	CD
cord-000248-zueoyesj	24	4	essential	essential	JJ
cord-000248-zueoyesj	24	5	alterations	alteration	NNS
cord-000248-zueoyesj	24	6	of	of	IN
cord-000248-zueoyesj	24	7	cell	cell	NN
cord-000248-zueoyesj	24	8	physiology	physiology	NN
cord-000248-zueoyesj	24	9	that	that	WDT
cord-000248-zueoyesj	24	10	generally	generally	RB
cord-000248-zueoyesj	24	11	occur	occur	VBP
cord-000248-zueoyesj	24	12	in	in	IN
cord-000248-zueoyesj	24	13	cancer	cancer	NN
cord-000248-zueoyesj	24	14	cells	cell	NNS
cord-000248-zueoyesj	24	15	independently	independently	RB
cord-000248-zueoyesj	24	16	of	of	IN
cord-000248-zueoyesj	24	17	the	the	DT
cord-000248-zueoyesj	24	18	originating	originate	VBG
cord-000248-zueoyesj	24	19	tissue	tissue	NN
cord-000248-zueoyesj	24	20	type	type	NN
cord-000248-zueoyesj	24	21	.	.	.
cord-000248-zueoyesj	25	1	They	-PRON-	PRP
cord-000248-zueoyesj	25	2	listed	list	VBD
cord-000248-zueoyesj	25	3	:	:	:
cord-000248-zueoyesj	25	4	'	'	''
cord-000248-zueoyesj	25	5	'	'	``
cord-000248-zueoyesj	25	6	self	self	NN
cord-000248-zueoyesj	25	7	-	-	HYPH
cord-000248-zueoyesj	25	8	sufficiency	sufficiency	NN
cord-000248-zueoyesj	25	9	in	in	IN
cord-000248-zueoyesj	25	10	growth	growth	NN
cord-000248-zueoyesj	25	11	signals	signal	NNS
cord-000248-zueoyesj	25	12	,	,	,
cord-000248-zueoyesj	25	13	insensitivity	insensitivity	NN
cord-000248-zueoyesj	25	14	to	to	IN
cord-000248-zueoyesj	25	15	growth	growth	NN
cord-000248-zueoyesj	25	16	-	-	HYPH
cord-000248-zueoyesj	25	17	inhibitory	inhibitory	JJ
cord-000248-zueoyesj	25	18	signals	signal	NNS
cord-000248-zueoyesj	25	19	,	,	,
cord-000248-zueoyesj	25	20	evasion	evasion	NN
cord-000248-zueoyesj	25	21	of	of	IN
cord-000248-zueoyesj	25	22	the	the	DT
cord-000248-zueoyesj	25	23	normal	normal	JJ
cord-000248-zueoyesj	25	24	programmed	program	VBN
cord-000248-zueoyesj	25	25	-	-	HYPH
cord-000248-zueoyesj	25	26	cell	cell	NN
cord-000248-zueoyesj	25	27	mechanisms	mechanism	NNS
cord-000248-zueoyesj	25	28	(	(	-LRB-
cord-000248-zueoyesj	25	29	apoptosis	apoptosis	NN
cord-000248-zueoyesj	25	30	)	)	-RRB-
cord-000248-zueoyesj	25	31	,	,	,
cord-000248-zueoyesj	25	32	limitless	limitless	JJ
cord-000248-zueoyesj	25	33	replicative	replicative	JJ
cord-000248-zueoyesj	25	34	potential	potential	NN
cord-000248-zueoyesj	25	35	,	,	,
cord-000248-zueoyesj	25	36	sustained	sustained	JJ
cord-000248-zueoyesj	25	37	angiogenesis	angiogenesis	NN
cord-000248-zueoyesj	25	38	,	,	,
cord-000248-zueoyesj	25	39	and	and	CC
cord-000248-zueoyesj	25	40	finally	finally	RB
cord-000248-zueoyesj	25	41	,	,	,
cord-000248-zueoyesj	25	42	tissue	tissue	NN
cord-000248-zueoyesj	25	43	invasion	invasion	NN
cord-000248-zueoyesj	25	44	and	and	CC
cord-000248-zueoyesj	25	45	metastasis	metastasis	NN
cord-000248-zueoyesj	25	46	'	'	''
cord-000248-zueoyesj	25	47	'	'	''
cord-000248-zueoyesj	25	48	.	.	.
cord-000248-zueoyesj	26	1	More	more	RBR
cord-000248-zueoyesj	26	2	recently	recently	RB
cord-000248-zueoyesj	26	3	,	,	,
cord-000248-zueoyesj	26	4	several	several	JJ
cord-000248-zueoyesj	26	5	researchers	researcher	NNS
cord-000248-zueoyesj	26	6	have	have	VBP
cord-000248-zueoyesj	26	7	advocated	advocate	VBN
cord-000248-zueoyesj	26	8	including	include	VBG
cord-000248-zueoyesj	26	9	'	'	``
cord-000248-zueoyesj	26	10	'	'	``
cord-000248-zueoyesj	26	11	stemness	stemness	NN
cord-000248-zueoyesj	26	12	'	'	''
cord-000248-zueoyesj	26	13	'	'	''
cord-000248-zueoyesj	26	14	as	as	IN
cord-000248-zueoyesj	26	15	the	the	DT
cord-000248-zueoyesj	26	16	seventh	seventh	JJ
cord-000248-zueoyesj	26	17	hallmark	hallmark	NN
cord-000248-zueoyesj	26	18	of	of	IN
cord-000248-zueoyesj	26	19	cancer	cancer	NN
cord-000248-zueoyesj	26	20	cells	cell	NNS
cord-000248-zueoyesj	26	21	.	.	.
cord-000248-zueoyesj	27	1	This	this	DT
cord-000248-zueoyesj	27	2	conclusion	conclusion	NN
cord-000248-zueoyesj	27	3	has	have	VBZ
cord-000248-zueoyesj	27	4	been	be	VBN
cord-000248-zueoyesj	27	5	reached	reach	VBN
cord-000248-zueoyesj	27	6	from	from	IN
cord-000248-zueoyesj	27	7	the	the	DT
cord-000248-zueoyesj	27	8	outcomes	outcome	NNS
cord-000248-zueoyesj	27	9	of	of	IN
cord-000248-zueoyesj	27	10	the	the	DT
cord-000248-zueoyesj	27	11	analysis	analysis	NN
cord-000248-zueoyesj	27	12	of	of	IN
cord-000248-zueoyesj	27	13	high	high	JJ
cord-000248-zueoyesj	27	14	-	-	HYPH
cord-000248-zueoyesj	27	15	throughput	throughput	NN
cord-000248-zueoyesj	27	16	gene	gene	NN
cord-000248-zueoyesj	27	17	expression	expression	NN
cord-000248-zueoyesj	27	18	datasets	dataset	NNS
cord-000248-zueoyesj	27	19	[	[	-LRB-
cord-000248-zueoyesj	27	20	2	2	CD
cord-000248-zueoyesj	27	21	,	,	,
cord-000248-zueoyesj	27	22	3	3	CD
cord-000248-zueoyesj	27	23	]	]	-RRB-
cord-000248-zueoyesj	27	24	.	.	.
cord-000248-zueoyesj	28	1	The	the	DT
cord-000248-zueoyesj	28	2	new	new	JJ
cord-000248-zueoyesj	28	3	role	role	NN
cord-000248-zueoyesj	28	4	of	of	IN
cord-000248-zueoyesj	28	5	stemness	stemness	NNP
cord-000248-zueoyesj	28	6	as	as	IN
cord-000248-zueoyesj	28	7	a	a	DT
cord-000248-zueoyesj	28	8	hallmark	hallmark	JJ
cord-000248-zueoyesj	28	9	change	change	NN
cord-000248-zueoyesj	28	10	of	of	IN
cord-000248-zueoyesj	28	11	cancer	cancer	NN
cord-000248-zueoyesj	28	12	cells	cell	NNS
cord-000248-zueoyesj	28	13	is	be	VBZ
cord-000248-zueoyesj	28	14	also	also	RB
cord-000248-zueoyesj	28	15	supported	support	VBN
cord-000248-zueoyesj	28	16	by	by	IN
cord-000248-zueoyesj	28	17	the	the	DT
cord-000248-zueoyesj	28	18	observation	observation	NN
cord-000248-zueoyesj	28	19	that	that	IN
cord-000248-zueoyesj	28	20	histologically	histologically	RB
cord-000248-zueoyesj	28	21	poorly	poorly	RB
cord-000248-zueoyesj	28	22	differentiated	differentiate	VBN
cord-000248-zueoyesj	28	23	tumors	tumor	NNS
cord-000248-zueoyesj	28	24	show	show	VBP
cord-000248-zueoyesj	28	25	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	28	26	profiles	profile	NNS
cord-000248-zueoyesj	28	27	on	on	IN
cord-000248-zueoyesj	28	28	which	which	WDT
cord-000248-zueoyesj	28	29	there	there	EX
cord-000248-zueoyesj	28	30	is	be	VBZ
cord-000248-zueoyesj	28	31	an	an	DT
cord-000248-zueoyesj	28	32	overexpression	overexpression	NN
cord-000248-zueoyesj	28	33	of	of	IN
cord-000248-zueoyesj	28	34	genes	gene	NNS
cord-000248-zueoyesj	28	35	normally	normally	RB
cord-000248-zueoyesj	28	36	enriched	enrich	VBN
cord-000248-zueoyesj	28	37	in	in	IN
cord-000248-zueoyesj	28	38	embryonic	embryonic	JJ
cord-000248-zueoyesj	28	39	stem	stem	NN
cord-000248-zueoyesj	28	40	cells	cell	NNS
cord-000248-zueoyesj	28	41	.	.	.
cord-000248-zueoyesj	29	1	For	for	IN
cord-000248-zueoyesj	29	2	example	example	NN
cord-000248-zueoyesj	29	3	,	,	,
cord-000248-zueoyesj	29	4	in	in	IN
cord-000248-zueoyesj	29	5	breast	breast	NN
cord-000248-zueoyesj	29	6	cancer	cancer	NN
cord-000248-zueoyesj	29	7	the	the	DT
cord-000248-zueoyesj	29	8	activation	activation	NN
cord-000248-zueoyesj	29	9	targets	target	NNS
cord-000248-zueoyesj	29	10	of	of	IN
cord-000248-zueoyesj	29	11	the	the	DT
cord-000248-zueoyesj	29	12	pluripotency	pluripotency	NN
cord-000248-zueoyesj	29	13	markers	marker	NNS
cord-000248-zueoyesj	29	14	like	like	IN
cord-000248-zueoyesj	29	15	NANOG	NANOG	NNP
cord-000248-zueoyesj	29	16	,	,	,
cord-000248-zueoyesj	29	17	OCT4	OCT4	NNP
cord-000248-zueoyesj	29	18	,	,	,
cord-000248-zueoyesj	29	19	SOX2	SOX2	NNP
cord-000248-zueoyesj	29	20	and	and	CC
cord-000248-zueoyesj	29	21	c	c	NNP
cord-000248-zueoyesj	29	22	-	-	HYPH
cord-000248-zueoyesj	29	23	MYC	MYC	NNP
cord-000248-zueoyesj	29	24	have	have	VBP
cord-000248-zueoyesj	29	25	been	be	VBN
cord-000248-zueoyesj	29	26	shown	show	VBN
cord-000248-zueoyesj	29	27	to	to	TO
cord-000248-zueoyesj	29	28	be	be	VB
cord-000248-zueoyesj	29	29	overexpressed	overexpresse	VBN
cord-000248-zueoyesj	29	30	in	in	IN
cord-000248-zueoyesj	29	31	poorly	poorly	RB
cord-000248-zueoyesj	29	32	differentiated	differentiate	VBN
cord-000248-zueoyesj	29	33	tumors	tumor	NNS
cord-000248-zueoyesj	29	34	in	in	IN
cord-000248-zueoyesj	29	35	marked	mark	VBN
cord-000248-zueoyesj	29	36	contrast	contrast	NN
cord-000248-zueoyesj	29	37	with	with	IN
cord-000248-zueoyesj	29	38	their	-PRON-	PRP$
cord-000248-zueoyesj	29	39	expression	expression	NN
cord-000248-zueoyesj	29	40	in	in	IN
cord-000248-zueoyesj	29	41	welldifferentiated	welldifferentiated	JJ
cord-000248-zueoyesj	29	42	tumors	tumor	NNS
cord-000248-zueoyesj	29	43	[	[	-LRB-
cord-000248-zueoyesj	29	44	4	4	CD
cord-000248-zueoyesj	29	45	]	]	-RRB-
cord-000248-zueoyesj	29	46	.	.	.
cord-000248-zueoyesj	30	1	Other	other	JJ
cord-000248-zueoyesj	30	2	authors	author	NNS
cord-000248-zueoyesj	30	3	suggest	suggest	VBP
cord-000248-zueoyesj	30	4	different	different	JJ
cord-000248-zueoyesj	30	5	hallmarks	hallmark	NNS
cord-000248-zueoyesj	30	6	,	,	,
cord-000248-zueoyesj	30	7	with	with	IN
cord-000248-zueoyesj	30	8	many	many	JJ
cord-000248-zueoyesj	30	9	papers	paper	NNS
cord-000248-zueoyesj	30	10	pointing	point	VBG
cord-000248-zueoyesj	30	11	alternative	alternative	JJ
cord-000248-zueoyesj	30	12	processes	process	NNS
cord-000248-zueoyesj	30	13	as	as	IN
cord-000248-zueoyesj	30	14	their	-PRON-	PRP$
cord-000248-zueoyesj	30	15	primary	primary	JJ
cord-000248-zueoyesj	30	16	focus	focus	NN
cord-000248-zueoyesj	30	17	of	of	IN
cord-000248-zueoyesj	30	18	their	-PRON-	PRP$
cord-000248-zueoyesj	30	19	research	research	NN
cord-000248-zueoyesj	30	20	.	.	.
cord-000248-zueoyesj	31	1	The	the	DT
cord-000248-zueoyesj	31	2	difference	difference	NN
cord-000248-zueoyesj	31	3	may	may	MD
cord-000248-zueoyesj	31	4	stem	stem	VB
cord-000248-zueoyesj	31	5	from	from	IN
cord-000248-zueoyesj	31	6	the	the	DT
cord-000248-zueoyesj	31	7	fact	fact	NN
cord-000248-zueoyesj	31	8	that	that	IN
cord-000248-zueoyesj	31	9	these	these	DT
cord-000248-zueoyesj	31	10	authors	author	NNS
cord-000248-zueoyesj	31	11	prefer	prefer	VBP
cord-000248-zueoyesj	31	12	to	to	TO
cord-000248-zueoyesj	31	13	cite	cite	VB
cord-000248-zueoyesj	31	14	as	as	IN
cord-000248-zueoyesj	31	15	'	'	''
cord-000248-zueoyesj	31	16	'	'	``
cord-000248-zueoyesj	31	17	key	key	JJ
cord-000248-zueoyesj	31	18	hallmarks	hallmark	NNS
cord-000248-zueoyesj	31	19	'	'	''
cord-000248-zueoyesj	31	20	'	'	``
cord-000248-zueoyesj	31	21	physiological	physiological	JJ
cord-000248-zueoyesj	31	22	changes	change	NNS
cord-000248-zueoyesj	31	23	which	which	WDT
cord-000248-zueoyesj	31	24	occur	occur	VBP
cord-000248-zueoyesj	31	25	at	at	IN
cord-000248-zueoyesj	31	26	a	a	DT
cord-000248-zueoyesj	31	27	'	'	''
cord-000248-zueoyesj	31	28	'	'	``
cord-000248-zueoyesj	31	29	lower	low	JJR
cord-000248-zueoyesj	31	30	level	level	NN
cord-000248-zueoyesj	31	31	'	'	''
cord-000248-zueoyesj	31	32	'	'	''
cord-000248-zueoyesj	31	33	scale	scale	NN
cord-000248-zueoyesj	31	34	closer	close	RBR
cord-000248-zueoyesj	31	35	to	to	IN
cord-000248-zueoyesj	31	36	the	the	DT
cord-000248-zueoyesj	31	37	molecular	molecular	JJ
cord-000248-zueoyesj	31	38	events	event	NNS
cord-000248-zueoyesj	31	39	.	.	.
cord-000248-zueoyesj	32	1	These	these	DT
cord-000248-zueoyesj	32	2	authors	author	NNS
cord-000248-zueoyesj	32	3	cite	cite	VBP
cord-000248-zueoyesj	32	4	,	,	,
cord-000248-zueoyesj	32	5	for	for	IN
cord-000248-zueoyesj	32	6	example	example	NN
cord-000248-zueoyesj	32	7	,	,	,
cord-000248-zueoyesj	32	8	'	'	''
cord-000248-zueoyesj	32	9	'	'	''
cord-000248-zueoyesj	32	10	mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	32	11	dysfunction	dysfunction	NN
cord-000248-zueoyesj	32	12	'	'	''
cord-000248-zueoyesj	32	13	'	'	''
cord-000248-zueoyesj	32	14	[	[	-LRB-
cord-000248-zueoyesj	32	15	5	5	CD
cord-000248-zueoyesj	32	16	,	,	,
cord-000248-zueoyesj	32	17	6	6	CD
cord-000248-zueoyesj	32	18	]	]	-RRB-
cord-000248-zueoyesj	32	19	(	(	-LRB-
cord-000248-zueoyesj	32	20	including	include	VBG
cord-000248-zueoyesj	32	21	,	,	,
cord-000248-zueoyesj	32	22	but	but	CC
cord-000248-zueoyesj	32	23	not	not	RB
cord-000248-zueoyesj	32	24	limited	limited	JJ
cord-000248-zueoyesj	32	25	to	to	IN
cord-000248-zueoyesj	32	26	'	'	''
cord-000248-zueoyesj	32	27	'	'	''
cord-000248-zueoyesj	32	28	glucose	glucose	NN
cord-000248-zueoyesj	32	29	avidity	avidity	NN
cord-000248-zueoyesj	32	30	'	'	''
cord-000248-zueoyesj	32	31	'	'	''
cord-000248-zueoyesj	32	32	[	[	-LRB-
cord-000248-zueoyesj	32	33	7	7	CD
cord-000248-zueoyesj	32	34	]	]	-RRB-
cord-000248-zueoyesj	32	35	and	and	CC
cord-000248-zueoyesj	32	36	'	'	``
cord-000248-zueoyesj	32	37	'	'	''
cord-000248-zueoyesj	32	38	a	a	DT
cord-000248-zueoyesj	32	39	shift	shift	NN
cord-000248-zueoyesj	32	40	in	in	IN
cord-000248-zueoyesj	32	41	glucosemetabolism	glucosemetabolism	NN
cord-000248-zueoyesj	32	42	from	from	IN
cord-000248-zueoyesj	32	43	oxidative	oxidative	JJ
cord-000248-zueoyesj	32	44	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	32	45	to	to	IN
cord-000248-zueoyesj	32	46	glycolysis	glycolysis	NN
cord-000248-zueoyesj	32	47	'	'	''
cord-000248-zueoyesj	32	48	'	'	''
cord-000248-zueoyesj	32	49	[	[	-LRB-
cord-000248-zueoyesj	32	50	6	6	CD
cord-000248-zueoyesj	32	51	,	,	,
cord-000248-zueoyesj	32	52	8	8	CD
cord-000248-zueoyesj	32	53	]	]	-RRB-
cord-000248-zueoyesj	32	54	,	,	,
cord-000248-zueoyesj	32	55	'	'	''
cord-000248-zueoyesj	32	56	'	'	''
cord-000248-zueoyesj	32	57	altered	alter	VBN
cord-000248-zueoyesj	32	58	glycolysis	glycolysis	NN
cord-000248-zueoyesj	32	59	'	'	''
cord-000248-zueoyesj	32	60	'	'	''
cord-000248-zueoyesj	32	61	[	[	-LRB-
cord-000248-zueoyesj	32	62	9	9	CD
cord-000248-zueoyesj	32	63	]	]	-RRB-
cord-000248-zueoyesj	32	64	,	,	,
cord-000248-zueoyesj	32	65	'	'	''
cord-000248-zueoyesj	32	66	'	'	''
cord-000248-zueoyesj	32	67	altered	alter	VBN
cord-000248-zueoyesj	32	68	bioenergetic	bioenergetic	JJ
cord-000248-zueoyesj	32	69	function	function	NN
cord-000248-zueoyesj	32	70	of	of	IN
cord-000248-zueoyesj	32	71	mitochondria	mitochondrion	NNS
cord-000248-zueoyesj	32	72	'	'	''
cord-000248-zueoyesj	32	73	'	'	''
cord-000248-zueoyesj	32	74	[	[	-LRB-
cord-000248-zueoyesj	32	75	10	10	CD
cord-000248-zueoyesj	32	76	]	]	-RRB-
cord-000248-zueoyesj	32	77	)	)	-RRB-
cord-000248-zueoyesj	32	78	,	,	,
cord-000248-zueoyesj	32	79	'	'	''
cord-000248-zueoyesj	32	80	'	'	''
cord-000248-zueoyesj	32	81	dysregulation	dysregulation	NN
cord-000248-zueoyesj	32	82	of	of	IN
cord-000248-zueoyesj	32	83	cell	cell	NN
cord-000248-zueoyesj	32	84	cycle	cycle	NN
cord-000248-zueoyesj	32	85	and	and	CC
cord-000248-zueoyesj	32	86	defective	defective	JJ
cord-000248-zueoyesj	32	87	genome	genome	NN
cord-000248-zueoyesj	32	88	-	-	HYPH
cord-000248-zueoyesj	32	89	integrity	integrity	NN
cord-000248-zueoyesj	32	90	checkpoints	checkpoint	NNS
cord-000248-zueoyesj	32	91	'	'	POS
cord-000248-zueoyesj	32	92	'	'	''
cord-000248-zueoyesj	32	93	[	[	-LRB-
cord-000248-zueoyesj	32	94	11	11	CD
cord-000248-zueoyesj	32	95	]	]	-RRB-
cord-000248-zueoyesj	32	96	,	,	,
cord-000248-zueoyesj	32	97	'	'	''
cord-000248-zueoyesj	32	98	'	'	``
cord-000248-zueoyesj	32	99	aberrant	aberrant	JJ
cord-000248-zueoyesj	32	100	DNA	dna	NN
cord-000248-zueoyesj	32	101	methylation	methylation	NN
cord-000248-zueoyesj	32	102	'	'	''
cord-000248-zueoyesj	32	103	'	'	''
cord-000248-zueoyesj	32	104	[	[	-LRB-
cord-000248-zueoyesj	32	105	12	12	CD
cord-000248-zueoyesj	32	106	]	]	-RRB-
cord-000248-zueoyesj	32	107	(	(	-LRB-
cord-000248-zueoyesj	32	108	'	'	''
cord-000248-zueoyesj	32	109	'	'	''
cord-000248-zueoyesj	32	110	promoter	promoter	NN
cord-000248-zueoyesj	32	111	hypermethylation	hypermethylation	NN
cord-000248-zueoyesj	32	112	of	of	IN
cord-000248-zueoyesj	32	113	hallmark	hallmark	JJ
cord-000248-zueoyesj	32	114	cancer	cancer	NN
cord-000248-zueoyesj	32	115	genes	gene	NNS
cord-000248-zueoyesj	32	116	'	'	POS
cord-000248-zueoyesj	32	117	'	'	''
cord-000248-zueoyesj	32	118	[	[	-LRB-
cord-000248-zueoyesj	32	119	13	13	CD
cord-000248-zueoyesj	32	120	]	]	-RRB-
cord-000248-zueoyesj	32	121	and	and	CC
cord-000248-zueoyesj	32	122	'	'	``
cord-000248-zueoyesj	32	123	'	'	''
cord-000248-zueoyesj	32	124	CpG	CpG	NNP
cord-000248-zueoyesj	32	125	island	island	NNP
cord-000248-zueoyesj	32	126	hypermethylation	hypermethylation	NNP
cord-000248-zueoyesj	32	127	and	and	CC
cord-000248-zueoyesj	32	128	global	global	JJ
cord-000248-zueoyesj	32	129	genomic	genomic	JJ
cord-000248-zueoyesj	32	130	hypomethylation	hypomethylation	NN
cord-000248-zueoyesj	32	131	'	'	''
cord-000248-zueoyesj	32	132	'	'	''
cord-000248-zueoyesj	32	133	[	[	-LRB-
cord-000248-zueoyesj	32	134	14	14	CD
cord-000248-zueoyesj	32	135	]	]	-RRB-
cord-000248-zueoyesj	32	136	)	)	-RRB-
cord-000248-zueoyesj	32	137	,	,	,
cord-000248-zueoyesj	32	138	'	'	''
cord-000248-zueoyesj	32	139	'	'	``
cord-000248-zueoyesj	32	140	shift	shift	NN
cord-000248-zueoyesj	32	141	in	in	IN
cord-000248-zueoyesj	32	142	cellular	cellular	JJ
cord-000248-zueoyesj	32	143	metabolism	metabolism	NN
cord-000248-zueoyesj	32	144	'	'	''
cord-000248-zueoyesj	32	145	'	'	''
cord-000248-zueoyesj	32	146	[	[	-LRB-
cord-000248-zueoyesj	32	147	15	15	CD
cord-000248-zueoyesj	32	148	,	,	,
cord-000248-zueoyesj	32	149	16	16	CD
cord-000248-zueoyesj	32	150	,	,	,
cord-000248-zueoyesj	32	151	17	17	CD
cord-000248-zueoyesj	32	152	]	]	-RRB-
cord-000248-zueoyesj	32	153	,	,	,
cord-000248-zueoyesj	32	154	'	'	''
cord-000248-zueoyesj	32	155	'	'	``
cord-000248-zueoyesj	32	156	regional	regional	JJ
cord-000248-zueoyesj	32	157	hypoxia	hypoxia	NN
cord-000248-zueoyesj	32	158	'	'	''
cord-000248-zueoyesj	32	159	'	'	''
cord-000248-zueoyesj	32	160	[	[	-LRB-
cord-000248-zueoyesj	32	161	18	18	CD
cord-000248-zueoyesj	32	162	]	]	-RRB-
cord-000248-zueoyesj	32	163	,	,	,
cord-000248-zueoyesj	32	164	'	'	''
cord-000248-zueoyesj	32	165	'	'	``
cord-000248-zueoyesj	32	166	microenviroment	microenviroment	NNP
cord-000248-zueoyesj	32	167	acidosis	acidosis	NN
cord-000248-zueoyesj	32	168	'	'	''
cord-000248-zueoyesj	32	169	'	'	''
cord-000248-zueoyesj	32	170	[	[	-LRB-
cord-000248-zueoyesj	32	171	19	19	CD
cord-000248-zueoyesj	32	172	]	]	-RRB-
cord-000248-zueoyesj	32	173	,	,	,
cord-000248-zueoyesj	32	174	'	'	''
cord-000248-zueoyesj	32	175	'	'	``
cord-000248-zueoyesj	32	176	abnormal	abnormal	JJ
cord-000248-zueoyesj	32	177	microRNA	microRNA	NNP
cord-000248-zueoyesj	32	178	regulation	regulation	NNP
cord-000248-zueoyesj	32	179	'	'	''
cord-000248-zueoyesj	32	180	'	'	''
cord-000248-zueoyesj	32	181	[	[	-LRB-
cord-000248-zueoyesj	32	182	20	20	CD
cord-000248-zueoyesj	32	183	,	,	,
cord-000248-zueoyesj	32	184	21	21	CD
cord-000248-zueoyesj	32	185	]	]	-RRB-
cord-000248-zueoyesj	32	186	,	,	,
cord-000248-zueoyesj	32	187	'	'	''
cord-000248-zueoyesj	32	188	'	'	``
cord-000248-zueoyesj	32	189	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	32	190	'	'	''
cord-000248-zueoyesj	32	191	'	'	''
cord-000248-zueoyesj	32	192	and	and	CC
cord-000248-zueoyesj	32	193	'	'	''
cord-000248-zueoyesj	32	194	'	'	''
cord-000248-zueoyesj	32	195	chromosome	chromosome	NN
cord-000248-zueoyesj	32	196	aberrations	aberration	NNS
cord-000248-zueoyesj	32	197	'	'	''
cord-000248-zueoyesj	32	198	'	'	''
cord-000248-zueoyesj	32	199	[	[	-LRB-
cord-000248-zueoyesj	32	200	22	22	CD
cord-000248-zueoyesj	32	201	,	,	,
cord-000248-zueoyesj	32	202	23	23	CD
cord-000248-zueoyesj	32	203	,	,	,
cord-000248-zueoyesj	32	204	24	24	CD
cord-000248-zueoyesj	32	205	,	,	,
cord-000248-zueoyesj	32	206	25	25	CD
cord-000248-zueoyesj	32	207	,	,	,
cord-000248-zueoyesj	32	208	26	26	CD
cord-000248-zueoyesj	32	209	]	]	-RRB-
cord-000248-zueoyesj	32	210	,	,	,
cord-000248-zueoyesj	32	211	'	'	''
cord-000248-zueoyesj	32	212	'	'	''
cord-000248-zueoyesj	32	213	disruption	disruption	NN
cord-000248-zueoyesj	32	214	of	of	IN
cord-000248-zueoyesj	32	215	cellular	cellular	JJ
cord-000248-zueoyesj	32	216	junctions	junction	NNS
cord-000248-zueoyesj	32	217	'	'	POS
cord-000248-zueoyesj	32	218	'	'	''
cord-000248-zueoyesj	32	219	[	[	-LRB-
cord-000248-zueoyesj	32	220	27	27	CD
cord-000248-zueoyesj	32	221	]	]	-RRB-
cord-000248-zueoyesj	32	222	,	,	,
cord-000248-zueoyesj	32	223	'	'	''
cord-000248-zueoyesj	32	224	'	'	''
cord-000248-zueoyesj	32	225	avoidance	avoidance	NN
cord-000248-zueoyesj	32	226	of	of	IN
cord-000248-zueoyesj	32	227	the	the	DT
cord-000248-zueoyesj	32	228	immune	immune	JJ
cord-000248-zueoyesj	32	229	response	response	NN
cord-000248-zueoyesj	32	230	'	'	''
cord-000248-zueoyesj	32	231	'	'	''
cord-000248-zueoyesj	32	232	[	[	-LRB-
cord-000248-zueoyesj	32	233	28	28	CD
cord-000248-zueoyesj	32	234	]	]	-RRB-
cord-000248-zueoyesj	32	235	,	,	,
cord-000248-zueoyesj	32	236	'	'	''
cord-000248-zueoyesj	32	237	'	'	''
cord-000248-zueoyesj	32	238	pre	pre	JJ
cord-000248-zueoyesj	32	239	-	-	JJ
cord-000248-zueoyesj	32	240	existing	existing	JJ
cord-000248-zueoyesj	32	241	chronic	chronic	JJ
cord-000248-zueoyesj	32	242	inflammatory	inflammatory	JJ
cord-000248-zueoyesj	32	243	conditions	condition	NNS
cord-000248-zueoyesj	32	244	'	'	POS
cord-000248-zueoyesj	32	245	'	'	''
cord-000248-zueoyesj	32	246	[	[	-LRB-
cord-000248-zueoyesj	32	247	29	29	CD
cord-000248-zueoyesj	32	248	,	,	,
cord-000248-zueoyesj	32	249	30	30	CD
cord-000248-zueoyesj	32	250	]	]	-RRB-
cord-000248-zueoyesj	32	251	,	,	,
cord-000248-zueoyesj	32	252	'	'	''
cord-000248-zueoyesj	32	253	'	'	``
cord-000248-zueoyesj	32	254	cancerrelated	cancerrelated	JJ
cord-000248-zueoyesj	32	255	inflammation	inflammation	NN
cord-000248-zueoyesj	32	256	'	'	''
cord-000248-zueoyesj	32	257	'	'	''
cord-000248-zueoyesj	32	258	[	[	-LRB-
cord-000248-zueoyesj	32	259	29	29	CD
cord-000248-zueoyesj	32	260	]	]	-RRB-
cord-000248-zueoyesj	32	261	,	,	,
cord-000248-zueoyesj	32	262	'	'	''
cord-000248-zueoyesj	32	263	'	'	``
cord-000248-zueoyesj	32	264	disabled	disabled	JJ
cord-000248-zueoyesj	32	265	autophagy	autophagy	NN
cord-000248-zueoyesj	32	266	'	'	''
cord-000248-zueoyesj	32	267	'	'	''
cord-000248-zueoyesj	32	268	[	[	-LRB-
cord-000248-zueoyesj	32	269	28	28	CD
cord-000248-zueoyesj	32	270	]	]	-RRB-
cord-000248-zueoyesj	32	271	,	,	,
cord-000248-zueoyesj	32	272	'	'	''
cord-000248-zueoyesj	32	273	'	'	''
cord-000248-zueoyesj	32	274	impaired	impair	VBN
cord-000248-zueoyesj	32	275	cellular	cellular	JJ
cord-000248-zueoyesj	32	276	senescence	senescence	NN
cord-000248-zueoyesj	32	277	'	'	''
cord-000248-zueoyesj	32	278	'	'	''
cord-000248-zueoyesj	32	279	[	[	-LRB-
cord-000248-zueoyesj	32	280	31	31	CD
cord-000248-zueoyesj	32	281	]	]	-RRB-
cord-000248-zueoyesj	32	282	,	,	,
cord-000248-zueoyesj	32	283	'	'	''
cord-000248-zueoyesj	32	284	'	'	''
cord-000248-zueoyesj	32	285	altered	alter	VBN
cord-000248-zueoyesj	32	286	NF	NF	NNP
cord-000248-zueoyesj	32	287	-	-	HYPH
cord-000248-zueoyesj	32	288	kappaB	kappaB	NNP
cord-000248-zueoyesj	32	289	signalling	signal	VBG
cord-000248-zueoyesj	32	290	'	'	''
cord-000248-zueoyesj	32	291	'	'	''
cord-000248-zueoyesj	32	292	[	[	-LRB-
cord-000248-zueoyesj	32	293	32	32	CD
cord-000248-zueoyesj	32	294	]	]	-RRB-
cord-000248-zueoyesj	32	295	,	,	,
cord-000248-zueoyesj	32	296	'	'	''
cord-000248-zueoyesj	32	297	'	'	''
cord-000248-zueoyesj	32	298	altered	alter	VBN
cord-000248-zueoyesj	32	299	growth	growth	NN
cord-000248-zueoyesj	32	300	patterns	pattern	NNS
cord-000248-zueoyesj	32	301	,	,	,
cord-000248-zueoyesj	32	302	not	not	RB
cord-000248-zueoyesj	32	303	altered	alter	VBN
cord-000248-zueoyesj	32	304	growth	growth	NN
cord-000248-zueoyesj	32	305	per	per	FW
cord-000248-zueoyesj	32	306	se	se	FW
cord-000248-zueoyesj	32	307	'	'	''
cord-000248-zueoyesj	32	308	'	'	''
cord-000248-zueoyesj	32	309	[	[	-LRB-
cord-000248-zueoyesj	32	310	33	33	CD
cord-000248-zueoyesj	32	311	]	]	-RRB-
cord-000248-zueoyesj	32	312	,	,	,
cord-000248-zueoyesj	32	313	'	'	''
cord-000248-zueoyesj	32	314	'	'	``
cord-000248-zueoyesj	32	315	disregulated	disregulate	VBN
cord-000248-zueoyesj	32	316	DNA	dna	NN
cord-000248-zueoyesj	32	317	methylation	methylation	NN
cord-000248-zueoyesj	32	318	and	and	CC
cord-000248-zueoyesj	32	319	histone	histone	NN
cord-000248-zueoyesj	32	320	modifications	modification	NNS
cord-000248-zueoyesj	32	321	'	'	POS
cord-000248-zueoyesj	32	322	'	'	''
cord-000248-zueoyesj	32	323	[	[	-LRB-
cord-000248-zueoyesj	32	324	34	34	CD
cord-000248-zueoyesj	32	325	]	]	-RRB-
cord-000248-zueoyesj	32	326	,	,	,
cord-000248-zueoyesj	32	327	'	'	''
cord-000248-zueoyesj	32	328	'	'	''
cord-000248-zueoyesj	32	329	tissue	tissue	NN
cord-000248-zueoyesj	32	330	dedifferentiation	dedifferentiation	NN
cord-000248-zueoyesj	32	331	'	'	''
cord-000248-zueoyesj	32	332	'	'	''
cord-000248-zueoyesj	32	333	[	[	-LRB-
cord-000248-zueoyesj	32	334	35	35	CD
cord-000248-zueoyesj	32	335	,	,	,
cord-000248-zueoyesj	32	336	36	36	CD
cord-000248-zueoyesj	32	337	]	]	-RRB-
cord-000248-zueoyesj	32	338	,	,	,
cord-000248-zueoyesj	32	339	and	and	CC
cord-000248-zueoyesj	32	340	'	'	''
cord-000248-zueoyesj	32	341	'	'	''
cord-000248-zueoyesj	32	342	somatically	somatically	RB
cord-000248-zueoyesj	32	343	heritable	heritable	JJ
cord-000248-zueoyesj	32	344	molecular	molecular	JJ
cord-000248-zueoyesj	32	345	alterations	alteration	NNS
cord-000248-zueoyesj	32	346	'	'	POS
cord-000248-zueoyesj	32	347	'	'	''
cord-000248-zueoyesj	32	348	[	[	-LRB-
cord-000248-zueoyesj	32	349	37	37	CD
cord-000248-zueoyesj	32	350	]	]	-RRB-
cord-000248-zueoyesj	32	351	.	.	.
cord-000248-zueoyesj	33	1	This	this	DT
cord-000248-zueoyesj	33	2	research	research	NN
cord-000248-zueoyesj	33	3	enriches	enrich	VBZ
cord-000248-zueoyesj	33	4	the	the	DT
cord-000248-zueoyesj	33	5	list	list	NN
cord-000248-zueoyesj	33	6	of	of	IN
cord-000248-zueoyesj	33	7	the	the	DT
cord-000248-zueoyesj	33	8	most	most	RBS
cord-000248-zueoyesj	33	9	important	important	JJ
cord-000248-zueoyesj	33	10	cancer	cancer	NN
cord-000248-zueoyesj	33	11	hallmarks	hallmark	NNS
cord-000248-zueoyesj	33	12	.	.	.
cord-000248-zueoyesj	34	1	However	however	RB
cord-000248-zueoyesj	34	2	,	,	,
cord-000248-zueoyesj	34	3	these	these	DT
cord-000248-zueoyesj	34	4	physiological	physiological	JJ
cord-000248-zueoyesj	34	5	changes	change	NNS
cord-000248-zueoyesj	34	6	occur	occur	VBP
cord-000248-zueoyesj	34	7	at	at	IN
cord-000248-zueoyesj	34	8	a	a	DT
cord-000248-zueoyesj	34	9	'	'	``
cord-000248-zueoyesj	34	10	'	'	``
cord-000248-zueoyesj	34	11	lower	low	JJR
cord-000248-zueoyesj	34	12	'	'	''
cord-000248-zueoyesj	34	13	'	'	''
cord-000248-zueoyesj	34	14	molecular	molecular	JJ
cord-000248-zueoyesj	34	15	level	level	NN
cord-000248-zueoyesj	34	16	they	-PRON-	PRP
cord-000248-zueoyesj	34	17	are	be	VBP
cord-000248-zueoyesj	34	18	likely	likely	RB
cord-000248-zueoyesj	34	19	related	relate	VBN
cord-000248-zueoyesj	34	20	sub	sub	NN
cord-000248-zueoyesj	34	21	events	event	NNS
cord-000248-zueoyesj	34	22	of	of	IN
cord-000248-zueoyesj	34	23	the	the	DT
cord-000248-zueoyesj	34	24	orginial	orginial	JJ
cord-000248-zueoyesj	34	25	seven	seven	CD
cord-000248-zueoyesj	34	26	instead	instead	RB
cord-000248-zueoyesj	34	27	of	of	IN
cord-000248-zueoyesj	35	1	newly	newly	RB
cord-000248-zueoyesj	35	2	discovered	discover	VBN
cord-000248-zueoyesj	35	3	'	'	''
cord-000248-zueoyesj	35	4	'	'	``
cord-000248-zueoyesj	35	5	key	key	JJ
cord-000248-zueoyesj	35	6	hallmarks	hallmark	NNS
cord-000248-zueoyesj	35	7	'	'	''
cord-000248-zueoyesj	35	8	'	'	''
cord-000248-zueoyesj	35	9	.	.	.
cord-000248-zueoyesj	36	1	More	more	RBR
cord-000248-zueoyesj	36	2	recently	recently	RB
cord-000248-zueoyesj	36	3	,	,	,
cord-000248-zueoyesj	36	4	Luo	Luo	NNP
cord-000248-zueoyesj	36	5	et	et	NNP
cord-000248-zueoyesj	36	6	al	al	NNP
cord-000248-zueoyesj	36	7	attempted	attempt	VBD
cord-000248-zueoyesj	36	8	a	a	DT
cord-000248-zueoyesj	36	9	'	'	``
cord-000248-zueoyesj	36	10	'	'	''
cord-000248-zueoyesj	36	11	stress	stress	NN
cord-000248-zueoyesj	36	12	-	-	HYPH
cord-000248-zueoyesj	36	13	based	base	VBN
cord-000248-zueoyesj	36	14	'	'	''
cord-000248-zueoyesj	36	15	'	'	''
cord-000248-zueoyesj	36	16	description	description	NN
cord-000248-zueoyesj	36	17	of	of	IN
cord-000248-zueoyesj	36	18	some	some	DT
cord-000248-zueoyesj	36	19	of	of	IN
cord-000248-zueoyesj	36	20	the	the	DT
cord-000248-zueoyesj	36	21	hallmarks	hallmark	NNS
cord-000248-zueoyesj	36	22	in	in	IN
cord-000248-zueoyesj	36	23	terms	term	NNS
cord-000248-zueoyesj	36	24	of	of	IN
cord-000248-zueoyesj	36	25	'	'	''
cord-000248-zueoyesj	36	26	'	'	``
cord-000248-zueoyesj	36	27	stresses	stress	NNS
cord-000248-zueoyesj	36	28	'	'	''
cord-000248-zueoyesj	36	29	'	'	''
cord-000248-zueoyesj	36	30	(	(	-LRB-
cord-000248-zueoyesj	36	31	'	'	''
cord-000248-zueoyesj	36	32	'	'	``
cord-000248-zueoyesj	36	33	DNA	dna	NN
cord-000248-zueoyesj	36	34	damage	damage	NN
cord-000248-zueoyesj	36	35	/	/	SYM
cord-000248-zueoyesj	36	36	replication	replication	NN
cord-000248-zueoyesj	36	37	stress	stress	NN
cord-000248-zueoyesj	36	38	,	,	,
cord-000248-zueoyesj	36	39	proteotoxic	proteotoxic	JJ
cord-000248-zueoyesj	36	40	stress	stress	NN
cord-000248-zueoyesj	36	41	,	,	,
cord-000248-zueoyesj	36	42	mitotic	mitotic	JJ
cord-000248-zueoyesj	36	43	stress	stress	NN
cord-000248-zueoyesj	36	44	,	,	,
cord-000248-zueoyesj	36	45	metabolic	metabolic	JJ
cord-000248-zueoyesj	36	46	stress	stress	NN
cord-000248-zueoyesj	36	47	,	,	,
cord-000248-zueoyesj	36	48	and	and	CC
cord-000248-zueoyesj	36	49	oxidative	oxidative	JJ
cord-000248-zueoyesj	36	50	stress	stress	NN
cord-000248-zueoyesj	36	51	'	'	''
cord-000248-zueoyesj	36	52	'	'	''
cord-000248-zueoyesj	36	53	)	)	-RRB-
cord-000248-zueoyesj	36	54	[	[	-LRB-
cord-000248-zueoyesj	36	55	38	38	CD
cord-000248-zueoyesj	36	56	]	]	-RRB-
cord-000248-zueoyesj	36	57	.	.	.
cord-000248-zueoyesj	37	1	While	while	IN
cord-000248-zueoyesj	37	2	this	this	DT
cord-000248-zueoyesj	37	3	is	be	VBZ
cord-000248-zueoyesj	37	4	an	an	DT
cord-000248-zueoyesj	37	5	interesting	interesting	JJ
cord-000248-zueoyesj	37	6	descriptive	descriptive	JJ
cord-000248-zueoyesj	37	7	grouping	grouping	NN
cord-000248-zueoyesj	37	8	,	,	,
cord-000248-zueoyesj	37	9	it	-PRON-	PRP
cord-000248-zueoyesj	37	10	is	be	VBZ
cord-000248-zueoyesj	37	11	still	still	RB
cord-000248-zueoyesj	37	12	a	a	DT
cord-000248-zueoyesj	37	13	phenotypical	phenotypical	JJ
cord-000248-zueoyesj	37	14	characterization	characterization	NN
cord-000248-zueoyesj	37	15	.	.	.
cord-000248-zueoyesj	38	1	What	what	WP
cord-000248-zueoyesj	38	2	is	be	VBZ
cord-000248-zueoyesj	38	3	needed	need	VBN
cord-000248-zueoyesj	38	4	is	be	VBZ
cord-000248-zueoyesj	38	5	a	a	DT
cord-000248-zueoyesj	38	6	higher	high	JJR
cord-000248-zueoyesj	38	7	level	level	NN
cord-000248-zueoyesj	38	8	unifying	unify	VBG
cord-000248-zueoyesj	38	9	genotypical	genotypical	JJ
cord-000248-zueoyesj	38	10	characterization	characterization	NN
cord-000248-zueoyesj	38	11	,	,	,
cord-000248-zueoyesj	38	12	from	from	IN
cord-000248-zueoyesj	38	13	which	which	WDT
cord-000248-zueoyesj	38	14	individual	individual	JJ
cord-000248-zueoyesj	38	15	disregulated	disregulate	VBN
cord-000248-zueoyesj	38	16	processes	process	NNS
cord-000248-zueoyesj	38	17	can	can	MD
cord-000248-zueoyesj	38	18	be	be	VB
cord-000248-zueoyesj	38	19	identified	identify	VBN
cord-000248-zueoyesj	38	20	in	in	IN
cord-000248-zueoyesj	38	21	a	a	DT
cord-000248-zueoyesj	38	22	quantitative	quantitative	JJ
cord-000248-zueoyesj	38	23	way	way	NN
cord-000248-zueoyesj	38	24	using	use	VBG
cord-000248-zueoyesj	38	25	the	the	DT
cord-000248-zueoyesj	38	26	existing	exist	VBG
cord-000248-zueoyesj	38	27	high	high	JJ
cord-000248-zueoyesj	38	28	-	-	HYPH
cord-000248-zueoyesj	38	29	throughput	throughput	NN
cord-000248-zueoyesj	38	30	data	datum	NNS
cord-000248-zueoyesj	38	31	capture	capture	NN
cord-000248-zueoyesj	38	32	methodologies	methodology	NNS
cord-000248-zueoyesj	38	33	.	.	.
cord-000248-zueoyesj	39	1	It	-PRON-	PRP
cord-000248-zueoyesj	39	2	is	be	VBZ
cord-000248-zueoyesj	39	3	clear	clear	JJ
cord-000248-zueoyesj	39	4	that	that	IN
cord-000248-zueoyesj	39	5	a	a	DT
cord-000248-zueoyesj	39	6	unifying	unifying	JJ
cord-000248-zueoyesj	39	7	hallmark	hallmark	NN
cord-000248-zueoyesj	39	8	is	be	VBZ
cord-000248-zueoyesj	39	9	needed	need	VBN
cord-000248-zueoyesj	39	10	if	if	IN
cord-000248-zueoyesj	39	11	we	-PRON-	PRP
cord-000248-zueoyesj	39	12	aim	aim	VBP
cord-000248-zueoyesj	39	13	at	at	IN
cord-000248-zueoyesj	39	14	quantifying	quantify	VBG
cord-000248-zueoyesj	39	15	the	the	DT
cord-000248-zueoyesj	39	16	cell	cell	NN
cord-000248-zueoyesj	39	17	's	's	POS
cord-000248-zueoyesj	39	18	progression	progression	NN
cord-000248-zueoyesj	39	19	.	.	.
cord-000248-zueoyesj	40	1	It	-PRON-	PRP
cord-000248-zueoyesj	40	2	is	be	VBZ
cord-000248-zueoyesj	40	3	then	then	RB
cord-000248-zueoyesj	40	4	evident	evident	JJ
cord-000248-zueoyesj	40	5	for	for	IN
cord-000248-zueoyesj	40	6	us	-PRON-	PRP
cord-000248-zueoyesj	40	7	that	that	IN
cord-000248-zueoyesj	40	8	a	a	DT
cord-000248-zueoyesj	40	9	unifying	unify	VBG
cord-000248-zueoyesj	40	10	mathematical	mathematical	JJ
cord-000248-zueoyesj	40	11	formalism	formalism	NN
cord-000248-zueoyesj	40	12	is	be	VBZ
cord-000248-zueoyesj	40	13	necessary	necessary	JJ
cord-000248-zueoyesj	40	14	to	to	TO
cord-000248-zueoyesj	40	15	uncover	uncover	VB
cord-000248-zueoyesj	40	16	the	the	DT
cord-000248-zueoyesj	40	17	cell	cell	NN
cord-000248-zueoyesj	40	18	transcriptome	transcriptome	NN
cord-000248-zueoyesj	40	19	's	's	POS
cord-000248-zueoyesj	40	20	progression	progression	NN
cord-000248-zueoyesj	40	21	from	from	IN
cord-000248-zueoyesj	40	22	a	a	DT
cord-000248-zueoyesj	40	23	normal	normal	JJ
cord-000248-zueoyesj	40	24	to	to	IN
cord-000248-zueoyesj	40	25	a	a	DT
cord-000248-zueoyesj	40	26	more	more	RBR
cord-000248-zueoyesj	40	27	malignant	malignant	JJ
cord-000248-zueoyesj	40	28	phenotype	phenotype	NN
cord-000248-zueoyesj	40	29	.	.	.
cord-000248-zueoyesj	41	1	We	-PRON-	PRP
cord-000248-zueoyesj	41	2	start	start	VBP
cord-000248-zueoyesj	41	3	our	-PRON-	PRP$
cord-000248-zueoyesj	41	4	quest	quest	NN
cord-000248-zueoyesj	41	5	assuming	assume	VBG
cord-000248-zueoyesj	41	6	an	an	DT
cord-000248-zueoyesj	41	7	implicit	implicit	JJ
cord-000248-zueoyesj	41	8	working	work	VBG
cord-000248-zueoyesj	41	9	hypothesis	hypothesis	NN
cord-000248-zueoyesj	41	10	common	common	JJ
cord-000248-zueoyesj	41	11	to	to	IN
cord-000248-zueoyesj	41	12	many	many	JJ
cord-000248-zueoyesj	41	13	research	research	NN
cord-000248-zueoyesj	41	14	groups	group	NNS
cord-000248-zueoyesj	41	15	around	around	IN
cord-000248-zueoyesj	41	16	the	the	DT
cord-000248-zueoyesj	41	17	world	world	NN
cord-000248-zueoyesj	41	18	:	:	:
cord-000248-zueoyesj	41	19	the	the	DT
cord-000248-zueoyesj	41	20	macroscopic	macroscopic	JJ
cord-000248-zueoyesj	41	21	physiological	physiological	JJ
cord-000248-zueoyesj	41	22	changes	change	NNS
cord-000248-zueoyesj	41	23	(	(	-LRB-
cord-000248-zueoyesj	41	24	i.e.	i.e.	FW
cord-000248-zueoyesj	41	25	Hanahan	Hanahan	NNP
cord-000248-zueoyesj	41	26	and	and	CC
cord-000248-zueoyesj	41	27	Weinberg	Weinberg	NNP
cord-000248-zueoyesj	41	28	's	's	POS
cord-000248-zueoyesj	41	29	'	'	``
cord-000248-zueoyesj	41	30	'	'	``
cord-000248-zueoyesj	41	31	hallmarks	hallmark	NNS
cord-000248-zueoyesj	41	32	'	'	''
cord-000248-zueoyesj	41	33	'	'	''
cord-000248-zueoyesj	41	34	)	)	-RRB-
cord-000248-zueoyesj	41	35	must	must	MD
cord-000248-zueoyesj	41	36	also	also	RB
cord-000248-zueoyesj	41	37	correlate	correlate	VB
cord-000248-zueoyesj	41	38	with	with	IN
cord-000248-zueoyesj	41	39	global	global	JJ
cord-000248-zueoyesj	41	40	alterations	alteration	NNS
cord-000248-zueoyesj	41	41	of	of	IN
cord-000248-zueoyesj	41	42	the	the	DT
cord-000248-zueoyesj	41	43	molecular	molecular	JJ
cord-000248-zueoyesj	41	44	profiles	profile	NNS
cord-000248-zueoyesj	41	45	of	of	IN
cord-000248-zueoyesj	41	46	gene	gene	NN
cord-000248-zueoyesj	41	47	transcription	transcription	NN
cord-000248-zueoyesj	41	48	.	.	.
cord-000248-zueoyesj	42	1	It	-PRON-	PRP
cord-000248-zueoyesj	42	2	is	be	VBZ
cord-000248-zueoyesj	42	3	also	also	RB
cord-000248-zueoyesj	42	4	assumed	assume	VBN
cord-000248-zueoyesj	42	5	that	that	IN
cord-000248-zueoyesj	42	6	the	the	DT
cord-000248-zueoyesj	42	7	'	'	``
cord-000248-zueoyesj	42	8	'	'	``
cord-000248-zueoyesj	42	9	hallmark	hallmark	JJ
cord-000248-zueoyesj	42	10	changes	change	NNS
cord-000248-zueoyesj	42	11	'	'	''
cord-000248-zueoyesj	42	12	'	'	''
cord-000248-zueoyesj	42	13	occur	occur	VBP
cord-000248-zueoyesj	42	14	along	along	IN
cord-000248-zueoyesj	42	15	a	a	DT
cord-000248-zueoyesj	42	16	certain	certain	JJ
cord-000248-zueoyesj	42	17	timeline	timeline	NN
cord-000248-zueoyesj	42	18	,	,	,
cord-000248-zueoyesj	42	19	but	but	CC
cord-000248-zueoyesj	42	20	that	that	IN
cord-000248-zueoyesj	42	21	some	some	DT
cord-000248-zueoyesj	42	22	of	of	IN
cord-000248-zueoyesj	42	23	the	the	DT
cord-000248-zueoyesj	42	24	sub	sub	NN
cord-000248-zueoyesj	42	25	-	-	NNS
cord-000248-zueoyesj	42	26	processes	process	NNS
cord-000248-zueoyesj	42	27	discussed	discuss	VBN
cord-000248-zueoyesj	42	28	before	before	RB
cord-000248-zueoyesj	42	29	are	be	VBP
cord-000248-zueoyesj	42	30	concurrent	concurrent	JJ
cord-000248-zueoyesj	42	31	.	.	.
cord-000248-zueoyesj	43	1	These	these	DT
cord-000248-zueoyesj	43	2	processes	process	NNS
cord-000248-zueoyesj	43	3	may	may	MD
cord-000248-zueoyesj	43	4	start	start	VB
cord-000248-zueoyesj	43	5	in	in	IN
cord-000248-zueoyesj	43	6	a	a	DT
cord-000248-zueoyesj	43	7	slow	slow	JJ
cord-000248-zueoyesj	43	8	incremental	incremental	JJ
cord-000248-zueoyesj	43	9	way	way	NN
cord-000248-zueoyesj	43	10	with	with	IN
cord-000248-zueoyesj	43	11	some	some	DT
cord-000248-zueoyesj	43	12	of	of	IN
cord-000248-zueoyesj	43	13	the	the	DT
cord-000248-zueoyesj	43	14	major	major	JJ
cord-000248-zueoyesj	43	15	changes	change	NNS
cord-000248-zueoyesj	43	16	being	be	VBG
cord-000248-zueoyesj	43	17	early	early	JJ
cord-000248-zueoyesj	43	18	events	event	NNS
cord-000248-zueoyesj	43	19	while	while	IN
cord-000248-zueoyesj	43	20	others	other	NNS
cord-000248-zueoyesj	43	21	(	(	-LRB-
cord-000248-zueoyesj	43	22	e.g.	e.g.	RB
cord-000248-zueoyesj	43	23	tissue	tissue	NN
cord-000248-zueoyesj	43	24	invasion	invasion	NN
cord-000248-zueoyesj	43	25	and	and	CC
cord-000248-zueoyesj	43	26	metastasis	metastasis	NN
cord-000248-zueoyesj	43	27	)	)	-RRB-
cord-000248-zueoyesj	43	28	are	be	VBP
cord-000248-zueoyesj	43	29	likely	likely	JJ
cord-000248-zueoyesj	43	30	later	later	JJ
cord-000248-zueoyesj	43	31	processes	process	NNS
cord-000248-zueoyesj	43	32	triggered	trigger	VBN
cord-000248-zueoyesj	43	33	by	by	IN
cord-000248-zueoyesj	43	34	new	new	JJ
cord-000248-zueoyesj	43	35	events	event	NNS
cord-000248-zueoyesj	43	36	during	during	IN
cord-000248-zueoyesj	43	37	cancer	cancer	NN
cord-000248-zueoyesj	43	38	progression	progression	NN
cord-000248-zueoyesj	43	39	.	.	.
cord-000248-zueoyesj	44	1	The	the	DT
cord-000248-zueoyesj	44	2	timeline	timeline	NN
cord-000248-zueoyesj	44	3	is	be	VBZ
cord-000248-zueoyesj	44	4	not	not	RB
cord-000248-zueoyesj	44	5	explicit	explicit	JJ
cord-000248-zueoyesj	44	6	and	and	CC
cord-000248-zueoyesj	44	7	it	-PRON-	PRP
cord-000248-zueoyesj	44	8	is	be	VBZ
cord-000248-zueoyesj	44	9	also	also	RB
cord-000248-zueoyesj	44	10	likely	likely	JJ
cord-000248-zueoyesj	44	11	that	that	IN
cord-000248-zueoyesj	44	12	cancer	cancer	NN
cord-000248-zueoyesj	44	13	subtypes	subtype	NNS
cord-000248-zueoyesj	44	14	progress	progress	VBP
cord-000248-zueoyesj	44	15	to	to	IN
cord-000248-zueoyesj	44	16	similar	similar	JJ
cord-000248-zueoyesj	44	17	timelines	timeline	NNS
cord-000248-zueoyesj	44	18	.	.	.
cord-000248-zueoyesj	45	1	In	in	IN
cord-000248-zueoyesj	45	2	some	some	DT
cord-000248-zueoyesj	45	3	cases	case	NNS
cord-000248-zueoyesj	45	4	the	the	DT
cord-000248-zueoyesj	45	5	sequence	sequence	NN
cord-000248-zueoyesj	45	6	of	of	IN
cord-000248-zueoyesj	45	7	events	event	NNS
cord-000248-zueoyesj	45	8	are	be	VBP
cord-000248-zueoyesj	45	9	better	well	RBR
cord-000248-zueoyesj	45	10	understood	understand	VBN
cord-000248-zueoyesj	45	11	(	(	-LRB-
cord-000248-zueoyesj	45	12	e.g.	e.g.	RB
cord-000248-zueoyesj	45	13	some	some	DT
cord-000248-zueoyesj	45	14	leukaemia	leukaemia	NN
cord-000248-zueoyesj	45	15	subtypes	subtype	NNS
cord-000248-zueoyesj	45	16	[	[	-LRB-
cord-000248-zueoyesj	45	17	39	39	CD
cord-000248-zueoyesj	45	18	]	]	-RRB-
cord-000248-zueoyesj	45	19	)	)	-RRB-
cord-000248-zueoyesj	45	20	.	.	.
cord-000248-zueoyesj	46	1	The	the	DT
cord-000248-zueoyesj	46	2	elicitation	elicitation	NN
cord-000248-zueoyesj	46	3	and	and	CC
cord-000248-zueoyesj	46	4	regulation	regulation	NN
cord-000248-zueoyesj	46	5	of	of	IN
cord-000248-zueoyesj	46	6	molecular	molecular	JJ
cord-000248-zueoyesj	46	7	events	event	NNS
cord-000248-zueoyesj	46	8	is	be	VBZ
cord-000248-zueoyesj	46	9	likely	likely	JJ
cord-000248-zueoyesj	46	10	to	to	TO
cord-000248-zueoyesj	46	11	be	be	VB
cord-000248-zueoyesj	46	12	an	an	DT
cord-000248-zueoyesj	46	13	ongoing	ongoing	JJ
cord-000248-zueoyesj	46	14	quest	quest	NN
cord-000248-zueoyesj	46	15	during	during	IN
cord-000248-zueoyesj	46	16	this	this	DT
cord-000248-zueoyesj	46	17	century	century	NN
cord-000248-zueoyesj	46	18	for	for	IN
cord-000248-zueoyesj	46	19	many	many	JJ
cord-000248-zueoyesj	46	20	types	type	NNS
cord-000248-zueoyesj	46	21	of	of	IN
cord-000248-zueoyesj	46	22	cancer	cancer	NN
cord-000248-zueoyesj	46	23	.	.	.
cord-000248-zueoyesj	47	1	It	-PRON-	PRP
cord-000248-zueoyesj	47	2	is	be	VBZ
cord-000248-zueoyesj	47	3	not	not	RB
cord-000248-zueoyesj	47	4	to	to	TO
cord-000248-zueoyesj	47	5	be	be	VB
cord-000248-zueoyesj	47	6	assumed	assume	VBN
cord-000248-zueoyesj	47	7	that	that	IN
cord-000248-zueoyesj	47	8	some	some	DT
cord-000248-zueoyesj	47	9	of	of	IN
cord-000248-zueoyesj	47	10	the	the	DT
cord-000248-zueoyesj	47	11	transitions	transition	NNS
cord-000248-zueoyesj	47	12	of	of	IN
cord-000248-zueoyesj	47	13	the	the	DT
cord-000248-zueoyesj	47	14	transcriptome	transcriptome	NN
cord-000248-zueoyesj	47	15	are	be	VBP
cord-000248-zueoyesj	47	16	gradual	gradual	JJ
cord-000248-zueoyesj	47	17	.	.	.
cord-000248-zueoyesj	48	1	That	that	DT
cord-000248-zueoyesj	48	2	is	be	VBZ
cord-000248-zueoyesj	48	3	a	a	DT
cord-000248-zueoyesj	48	4	hypothesis	hypothesis	NN
cord-000248-zueoyesj	48	5	that	that	WDT
cord-000248-zueoyesj	48	6	is	be	VBZ
cord-000248-zueoyesj	48	7	unnecessary	unnecessary	JJ
cord-000248-zueoyesj	48	8	in	in	IN
cord-000248-zueoyesj	48	9	this	this	DT
cord-000248-zueoyesj	48	10	study	study	NN
cord-000248-zueoyesj	48	11	.	.	.
cord-000248-zueoyesj	49	1	We	-PRON-	PRP
cord-000248-zueoyesj	49	2	envision	envision	VBP
cord-000248-zueoyesj	49	3	that	that	IN
cord-000248-zueoyesj	49	4	the	the	DT
cord-000248-zueoyesj	49	5	progression	progression	NN
cord-000248-zueoyesj	49	6	of	of	IN
cord-000248-zueoyesj	49	7	cancer	cancer	NN
cord-000248-zueoyesj	49	8	may	may	MD
cord-000248-zueoyesj	49	9	have	have	VB
cord-000248-zueoyesj	49	10	'	'	``
cord-000248-zueoyesj	49	11	'	'	``
cord-000248-zueoyesj	49	12	switches	switch	NNS
cord-000248-zueoyesj	49	13	'	'	''
cord-000248-zueoyesj	49	14	'	'	''
cord-000248-zueoyesj	49	15	,	,	,
cord-000248-zueoyesj	49	16	with	with	IN
cord-000248-zueoyesj	49	17	a	a	DT
cord-000248-zueoyesj	49	18	number	number	NN
cord-000248-zueoyesj	49	19	of	of	IN
cord-000248-zueoyesj	49	20	concurrent	concurrent	JJ
cord-000248-zueoyesj	49	21	converging	converging	JJ
cord-000248-zueoyesj	49	22	events	event	NNS
cord-000248-zueoyesj	49	23	leading	lead	VBG
cord-000248-zueoyesj	49	24	to	to	IN
cord-000248-zueoyesj	49	25	macroscopic	macroscopic	JJ
cord-000248-zueoyesj	49	26	observable	observable	JJ
cord-000248-zueoyesj	49	27	changes	change	NNS
cord-000248-zueoyesj	49	28	in	in	IN
cord-000248-zueoyesj	49	29	the	the	DT
cord-000248-zueoyesj	49	30	gene	gene	NN
cord-000248-zueoyesj	49	31	expression	expression	NN
cord-000248-zueoyesj	49	32	profile	profile	NN
cord-000248-zueoyesj	49	33	resulting	result	VBG
cord-000248-zueoyesj	49	34	in	in	IN
cord-000248-zueoyesj	49	35	dramatic	dramatic	JJ
cord-000248-zueoyesj	49	36	variations	variation	NNS
cord-000248-zueoyesj	49	37	of	of	IN
cord-000248-zueoyesj	49	38	expression	expression	NN
cord-000248-zueoyesj	49	39	patterns	pattern	NNS
cord-000248-zueoyesj	49	40	.	.	.
cord-000248-zueoyesj	50	1	For	for	IN
cord-000248-zueoyesj	50	2	instance	instance	NN
cord-000248-zueoyesj	50	3	,	,	,
cord-000248-zueoyesj	50	4	these	these	DT
cord-000248-zueoyesj	50	5	molecular	molecular	JJ
cord-000248-zueoyesj	50	6	switches	switch	NNS
cord-000248-zueoyesj	50	7	could	could	MD
cord-000248-zueoyesj	50	8	not	not	RB
cord-000248-zueoyesj	50	9	be	be	VB
cord-000248-zueoyesj	50	10	characterized	characterize	VBN
cord-000248-zueoyesj	50	11	by	by	IN
cord-000248-zueoyesj	50	12	an	an	DT
cord-000248-zueoyesj	50	13	'	'	``
cord-000248-zueoyesj	50	14	'	'	``
cord-000248-zueoyesj	50	15	oncogene	oncogene	NN
cord-000248-zueoyesj	50	16	'	'	''
cord-000248-zueoyesj	50	17	'	'	''
cord-000248-zueoyesj	50	18	but	but	CC
cord-000248-zueoyesj	50	19	by	by	IN
cord-000248-zueoyesj	50	20	a	a	DT
cord-000248-zueoyesj	50	21	large	large	JJ
cord-000248-zueoyesj	50	22	number	number	NN
cord-000248-zueoyesj	50	23	of	of	IN
cord-000248-zueoyesj	50	24	the	the	DT
cord-000248-zueoyesj	50	25	genes	gene	NNS
cord-000248-zueoyesj	50	26	that	that	WDT
cord-000248-zueoyesj	50	27	have	have	VBP
cord-000248-zueoyesj	50	28	changed	change	VBN
cord-000248-zueoyesj	50	29	its	-PRON-	PRP$
cord-000248-zueoyesj	50	30	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	50	31	state	state	NN
cord-000248-zueoyesj	50	32	.	.	.
cord-000248-zueoyesj	51	1	These	these	DT
cord-000248-zueoyesj	51	2	abrupt	abrupt	JJ
cord-000248-zueoyesj	51	3	changes	change	NNS
cord-000248-zueoyesj	51	4	may	may	MD
cord-000248-zueoyesj	51	5	be	be	VB
cord-000248-zueoyesj	51	6	triggered	trigger	VBN
cord-000248-zueoyesj	51	7	by	by	IN
cord-000248-zueoyesj	51	8	the	the	DT
cord-000248-zueoyesj	51	9	confluence	confluence	NN
cord-000248-zueoyesj	51	10	of	of	IN
cord-000248-zueoyesj	51	11	several	several	JJ
cord-000248-zueoyesj	51	12	non	non	JJ
cord-000248-zueoyesj	51	13	-	-	JJ
cord-000248-zueoyesj	51	14	linear	linear	JJ
cord-000248-zueoyesj	51	15	interactions	interaction	NNS
cord-000248-zueoyesj	51	16	,	,	,
cord-000248-zueoyesj	51	17	and	and	CC
cord-000248-zueoyesj	51	18	are	be	VBP
cord-000248-zueoyesj	51	19	likely	likely	JJ
cord-000248-zueoyesj	51	20	to	to	TO
cord-000248-zueoyesj	51	21	be	be	VB
cord-000248-zueoyesj	51	22	related	relate	VBN
cord-000248-zueoyesj	51	23	to	to	IN
cord-000248-zueoyesj	51	24	the	the	DT
cord-000248-zueoyesj	51	25	physiological	physiological	JJ
cord-000248-zueoyesj	51	26	hallmarks	hallmark	NNS
cord-000248-zueoyesj	51	27	we	-PRON-	PRP
cord-000248-zueoyesj	51	28	refer	refer	VBP
cord-000248-zueoyesj	51	29	to	to	IN
cord-000248-zueoyesj	51	30	above	above	RB
cord-000248-zueoyesj	51	31	.	.	.
cord-000248-zueoyesj	52	1	The	the	DT
cord-000248-zueoyesj	52	2	presence	presence	NN
cord-000248-zueoyesj	52	3	of	of	IN
cord-000248-zueoyesj	52	4	macroscopic	macroscopic	JJ
cord-000248-zueoyesj	52	5	observable	observable	JJ
cord-000248-zueoyesj	52	6	changes	change	NNS
cord-000248-zueoyesj	52	7	that	that	WDT
cord-000248-zueoyesj	52	8	are	be	VBP
cord-000248-zueoyesj	52	9	computable	computable	JJ
cord-000248-zueoyesj	52	10	from	from	IN
cord-000248-zueoyesj	52	11	a	a	DT
cord-000248-zueoyesj	52	12	large	large	JJ
cord-000248-zueoyesj	52	13	number	number	NN
cord-000248-zueoyesj	52	14	of	of	IN
cord-000248-zueoyesj	52	15	relatively	relatively	RB
cord-000248-zueoyesj	52	16	smaller	small	JJR
cord-000248-zueoyesj	52	17	changes	change	NNS
cord-000248-zueoyesj	52	18	mean	mean	VBP
cord-000248-zueoyesj	52	19	that	that	IN
cord-000248-zueoyesj	52	20	it	-PRON-	PRP
cord-000248-zueoyesj	52	21	may	may	MD
cord-000248-zueoyesj	52	22	be	be	VB
cord-000248-zueoyesj	52	23	possible	possible	JJ
cord-000248-zueoyesj	52	24	to	to	TO
cord-000248-zueoyesj	52	25	find	find	VB
cord-000248-zueoyesj	52	26	an	an	DT
cord-000248-zueoyesj	52	27	objective	objective	JJ
cord-000248-zueoyesj	52	28	mathematical	mathematical	JJ
cord-000248-zueoyesj	52	29	formalism	formalism	NN
cord-000248-zueoyesj	52	30	to	to	TO
cord-000248-zueoyesj	52	31	infer	infer	VB
cord-000248-zueoyesj	52	32	the	the	DT
cord-000248-zueoyesj	52	33	turning	turning	NN
cord-000248-zueoyesj	52	34	point	point	NN
cord-000248-zueoyesj	52	35	at	at	IN
cord-000248-zueoyesj	52	36	which	which	WDT
cord-000248-zueoyesj	52	37	these	these	DT
cord-000248-zueoyesj	52	38	radical	radical	JJ
cord-000248-zueoyesj	52	39	changes	change	NNS
cord-000248-zueoyesj	52	40	occur	occur	VBP
cord-000248-zueoyesj	52	41	.	.	.
cord-000248-zueoyesj	53	1	It	-PRON-	PRP
cord-000248-zueoyesj	53	2	is	be	VBZ
cord-000248-zueoyesj	53	3	then	then	RB
cord-000248-zueoyesj	53	4	evident	evident	JJ
cord-000248-zueoyesj	53	5	that	that	IN
cord-000248-zueoyesj	53	6	computing	compute	VBG
cord-000248-zueoyesj	53	7	the	the	DT
cord-000248-zueoyesj	53	8	Jensen	Jensen	NNP
cord-000248-zueoyesj	53	9	-	-	HYPH
cord-000248-zueoyesj	53	10	Shannon	Shannon	NNP
cord-000248-zueoyesj	53	11	divergences	divergence	NNS
cord-000248-zueoyesj	53	12	,	,	,
cord-000248-zueoyesj	53	13	the	the	DT
cord-000248-zueoyesj	53	14	Normalized	Normalized	NNP
cord-000248-zueoyesj	53	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	53	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	53	17	,	,	,
cord-000248-zueoyesj	53	18	and	and	CC
cord-000248-zueoyesj	53	19	the	the	DT
cord-000248-zueoyesj	53	20	Statistical	Statistical	NNP
cord-000248-zueoyesj	53	21	Complexity	Complexity	NNP
cord-000248-zueoyesj	53	22	of	of	IN
cord-000248-zueoyesj	53	23	samples	sample	NNS
cord-000248-zueoyesj	53	24	reveal	reveal	VBP
cord-000248-zueoyesj	53	25	different	different	JJ
cord-000248-zueoyesj	53	26	global	global	JJ
cord-000248-zueoyesj	53	27	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	53	28	changes	change	NNS
cord-000248-zueoyesj	53	29	.	.	.
cord-000248-zueoyesj	54	1	It	-PRON-	PRP
cord-000248-zueoyesj	54	2	is	be	VBZ
cord-000248-zueoyesj	54	3	,	,	,
cord-000248-zueoyesj	54	4	however	however	RB
cord-000248-zueoyesj	54	5	,	,	,
cord-000248-zueoyesj	54	6	not	not	RB
cord-000248-zueoyesj	54	7	easy	easy	JJ
cord-000248-zueoyesj	54	8	to	to	TO
cord-000248-zueoyesj	54	9	infer	infer	VB
cord-000248-zueoyesj	54	10	if	if	IN
cord-000248-zueoyesj	54	11	these	these	DT
cord-000248-zueoyesj	54	12	changes	change	NNS
cord-000248-zueoyesj	54	13	would	would	MD
cord-000248-zueoyesj	54	14	correlate	correlate	VB
cord-000248-zueoyesj	54	15	with	with	IN
cord-000248-zueoyesj	54	16	a	a	DT
cord-000248-zueoyesj	54	17	gradual	gradual	JJ
cord-000248-zueoyesj	54	18	progression	progression	NN
cord-000248-zueoyesj	54	19	or	or	CC
cord-000248-zueoyesj	54	20	sudden	sudden	JJ
cord-000248-zueoyesj	54	21	changes	change	NNS
cord-000248-zueoyesj	54	22	.	.	.
cord-000248-zueoyesj	55	1	However	however	RB
cord-000248-zueoyesj	55	2	,	,	,
cord-000248-zueoyesj	55	3	one	one	CD
cord-000248-zueoyesj	55	4	valid	valid	JJ
cord-000248-zueoyesj	55	5	mathematical	mathematical	JJ
cord-000248-zueoyesj	55	6	possibility	possibility	NN
cord-000248-zueoyesj	55	7	is	be	VBZ
cord-000248-zueoyesj	55	8	that	that	IN
cord-000248-zueoyesj	55	9	the	the	DT
cord-000248-zueoyesj	55	10	most	most	RBS
cord-000248-zueoyesj	55	11	important	important	JJ
cord-000248-zueoyesj	55	12	'	'	''
cord-000248-zueoyesj	55	13	'	'	''
cord-000248-zueoyesj	55	14	hallmark	hallmark	NN
cord-000248-zueoyesj	55	15	of	of	IN
cord-000248-zueoyesj	55	16	cancer	cancer	NN
cord-000248-zueoyesj	55	17	'	'	''
cord-000248-zueoyesj	55	18	'	'	''
cord-000248-zueoyesj	55	19	,	,	,
cord-000248-zueoyesj	55	20	a	a	DT
cord-000248-zueoyesj	55	21	unifying	unifying	JJ
cord-000248-zueoyesj	55	22	principle	principle	NN
cord-000248-zueoyesj	55	23	above	above	IN
cord-000248-zueoyesj	55	24	all	all	DT
cord-000248-zueoyesj	55	25	,	,	,
cord-000248-zueoyesj	55	26	is	be	VBZ
cord-000248-zueoyesj	55	27	the	the	DT
cord-000248-zueoyesj	55	28	existence	existence	NN
cord-000248-zueoyesj	55	29	of	of	IN
cord-000248-zueoyesj	55	30	a	a	DT
cord-000248-zueoyesj	55	31	measurable	measurable	JJ
cord-000248-zueoyesj	55	32	gradual	gradual	JJ
cord-000248-zueoyesj	55	33	'	'	''
cord-000248-zueoyesj	55	34	'	'	``
cord-000248-zueoyesj	55	35	progression	progression	NN
cord-000248-zueoyesj	55	36	'	'	''
cord-000248-zueoyesj	55	37	'	'	''
cord-000248-zueoyesj	55	38	from	from	IN
cord-000248-zueoyesj	55	39	a	a	DT
cord-000248-zueoyesj	55	40	well	well	RB
cord-000248-zueoyesj	55	41	-	-	HYPH
cord-000248-zueoyesj	55	42	differentiated	differentiate	VBN
cord-000248-zueoyesj	55	43	gene	gene	NN
cord-000248-zueoyesj	55	44	expression	expression	NN
cord-000248-zueoyesj	55	45	profile	profile	NN
cord-000248-zueoyesj	55	46	(	(	-LRB-
cord-000248-zueoyesj	55	47	corresponding	correspond	VBG
cord-000248-zueoyesj	55	48	to	to	IN
cord-000248-zueoyesj	55	49	a	a	DT
cord-000248-zueoyesj	55	50	healthy	healthy	JJ
cord-000248-zueoyesj	55	51	tissue	tissue	NN
cord-000248-zueoyesj	55	52	)	)	-RRB-
cord-000248-zueoyesj	55	53	.	.	.
cord-000248-zueoyesj	56	1	This	this	DT
cord-000248-zueoyesj	56	2	would	would	MD
cord-000248-zueoyesj	56	3	reveal	reveal	VB
cord-000248-zueoyesj	56	4	the	the	DT
cord-000248-zueoyesj	56	5	timeline	timeline	NN
cord-000248-zueoyesj	56	6	of	of	IN
cord-000248-zueoyesj	56	7	a	a	DT
cord-000248-zueoyesj	56	8	higher	high	JJR
cord-000248-zueoyesj	56	9	level	level	NN
cord-000248-zueoyesj	56	10	process	process	NN
cord-000248-zueoyesj	56	11	that	that	WDT
cord-000248-zueoyesj	56	12	is	be	VBZ
cord-000248-zueoyesj	56	13	observable	observable	JJ
cord-000248-zueoyesj	56	14	and	and	CC
cord-000248-zueoyesj	56	15	measurable	measurable	JJ
cord-000248-zueoyesj	56	16	via	via	IN
cord-000248-zueoyesj	56	17	a	a	DT
cord-000248-zueoyesj	56	18	change	change	NN
cord-000248-zueoyesj	56	19	of	of	IN
cord-000248-zueoyesj	56	20	Normalized	Normalized	NNP
cord-000248-zueoyesj	56	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	56	22	Entropy	Entropy	NNP
cord-000248-zueoyesj	56	23	and	and	CC
cord-000248-zueoyesj	56	24	an	an	DT
cord-000248-zueoyesj	56	25	increment	increment	NN
cord-000248-zueoyesj	56	26	of	of	IN
cord-000248-zueoyesj	56	27	Jensen	Jensen	NNP
cord-000248-zueoyesj	56	28	-	-	HYPH
cord-000248-zueoyesj	56	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	56	30	divergences	divergence	NNS
cord-000248-zueoyesj	56	31	from	from	IN
cord-000248-zueoyesj	56	32	the	the	DT
cord-000248-zueoyesj	56	33	originating	originate	VBG
cord-000248-zueoyesj	56	34	tissue	tissue	NN
cord-000248-zueoyesj	56	35	type	type	NN
cord-000248-zueoyesj	56	36	.	.	.
cord-000248-zueoyesj	57	1	If	if	IN
cord-000248-zueoyesj	57	2	this	this	DT
cord-000248-zueoyesj	57	3	is	be	VBZ
cord-000248-zueoyesj	57	4	the	the	DT
cord-000248-zueoyesj	57	5	case	case	NN
cord-000248-zueoyesj	57	6	,	,	,
cord-000248-zueoyesj	57	7	by	by	IN
cord-000248-zueoyesj	57	8	correlating	correlate	VBG
cord-000248-zueoyesj	57	9	the	the	DT
cord-000248-zueoyesj	57	10	changes	change	NNS
cord-000248-zueoyesj	57	11	in	in	IN
cord-000248-zueoyesj	57	12	Information	Information	NNP
cord-000248-zueoyesj	57	13	Theory	Theory	NNP
cord-000248-zueoyesj	57	14	quantifiers	quantifier	NNS
cord-000248-zueoyesj	57	15	with	with	IN
cord-000248-zueoyesj	57	16	the	the	DT
cord-000248-zueoyesj	57	17	expression	expression	NN
cord-000248-zueoyesj	57	18	of	of	IN
cord-000248-zueoyesj	57	19	the	the	DT
cord-000248-zueoyesj	57	20	genes	gene	NNS
cord-000248-zueoyesj	57	21	we	-PRON-	PRP
cord-000248-zueoyesj	57	22	would	would	MD
cord-000248-zueoyesj	57	23	be	be	VB
cord-000248-zueoyesj	57	24	able	able	JJ
cord-000248-zueoyesj	57	25	to	to	TO
cord-000248-zueoyesj	57	26	not	not	RB
cord-000248-zueoyesj	57	27	only	only	RB
cord-000248-zueoyesj	57	28	uncover	uncover	VB
cord-000248-zueoyesj	57	29	useful	useful	JJ
cord-000248-zueoyesj	57	30	biomarkers	biomarker	NNS
cord-000248-zueoyesj	57	31	to	to	TO
cord-000248-zueoyesj	57	32	track	track	VB
cord-000248-zueoyesj	57	33	this	this	DT
cord-000248-zueoyesj	57	34	progression	progression	NN
cord-000248-zueoyesj	57	35	but	but	CC
cord-000248-zueoyesj	57	36	to	to	TO
cord-000248-zueoyesj	57	37	explain	explain	VB
cord-000248-zueoyesj	57	38	the	the	DT
cord-000248-zueoyesj	57	39	'	'	``
cord-000248-zueoyesj	57	40	'	'	``
cord-000248-zueoyesj	57	41	hallmarks	hallmark	NNS
cord-000248-zueoyesj	57	42	'	'	''
cord-000248-zueoyesj	57	43	'	'	''
cord-000248-zueoyesj	57	44	in	in	IN
cord-000248-zueoyesj	57	45	an	an	DT
cord-000248-zueoyesj	57	46	ordered	order	VBN
cord-000248-zueoyesj	57	47	timeline	timeline	NN
cord-000248-zueoyesj	57	48	.	.	.
cord-000248-zueoyesj	58	1	The	the	DT
cord-000248-zueoyesj	58	2	timeline	timeline	NN
cord-000248-zueoyesj	58	3	also	also	RB
cord-000248-zueoyesj	58	4	yields	yield	VBZ
cord-000248-zueoyesj	58	5	clinical	clinical	JJ
cord-000248-zueoyesj	58	6	and	and	CC
cord-000248-zueoyesj	58	7	translational	translational	JJ
cord-000248-zueoyesj	58	8	important	important	JJ
cord-000248-zueoyesj	58	9	outcomes	outcome	NNS
cord-000248-zueoyesj	58	10	.	.	.
cord-000248-zueoyesj	59	1	Such	such	JJ
cord-000248-zueoyesj	59	2	analytical	analytical	JJ
cord-000248-zueoyesj	59	3	methodology	methodology	NN
cord-000248-zueoyesj	59	4	will	will	MD
cord-000248-zueoyesj	59	5	naturally	naturally	RB
cord-000248-zueoyesj	59	6	produce	produce	VB
cord-000248-zueoyesj	59	7	'	'	''
cord-000248-zueoyesj	59	8	'	'	''
cord-000248-zueoyesj	59	9	a	a	DT
cord-000248-zueoyesj	59	10	continuous	continuous	JJ
cord-000248-zueoyesj	59	11	staging	staging	NN
cord-000248-zueoyesj	59	12	'	'	''
cord-000248-zueoyesj	59	13	'	'	''
cord-000248-zueoyesj	59	14	of	of	IN
cord-000248-zueoyesj	59	15	the	the	DT
cord-000248-zueoyesj	59	16	cancer	cancer	NN
cord-000248-zueoyesj	59	17	samples	sample	NNS
cord-000248-zueoyesj	59	18	,	,	,
cord-000248-zueoyesj	59	19	based	base	VBN
cord-000248-zueoyesj	59	20	on	on	IN
cord-000248-zueoyesj	59	21	a	a	DT
cord-000248-zueoyesj	59	22	solid	solid	JJ
cord-000248-zueoyesj	59	23	foundations	foundation	NNS
cord-000248-zueoyesj	59	24	of	of	IN
cord-000248-zueoyesj	59	25	Information	Information	NNP
cord-000248-zueoyesj	59	26	Theory	Theory	NNP
cord-000248-zueoyesj	59	27	,	,	,
cord-000248-zueoyesj	59	28	based	base	VBN
cord-000248-zueoyesj	59	29	on	on	IN
cord-000248-zueoyesj	59	30	the	the	DT
cord-000248-zueoyesj	59	31	knowledge	knowledge	NN
cord-000248-zueoyesj	59	32	of	of	IN
cord-000248-zueoyesj	59	33	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	59	34	profile	profile	NN
cord-000248-zueoyesj	59	35	of	of	IN
cord-000248-zueoyesj	59	36	healthy	healthy	JJ
cord-000248-zueoyesj	59	37	cells	cell	NNS
cord-000248-zueoyesj	59	38	as	as	IN
cord-000248-zueoyesj	59	39	reference	reference	NN
cord-000248-zueoyesj	59	40	to	to	TO
cord-000248-zueoyesj	59	41	measure	measure	VB
cord-000248-zueoyesj	59	42	divergences	divergence	NNS
cord-000248-zueoyesj	59	43	.	.	.
cord-000248-zueoyesj	60	1	In	in	IN
cord-000248-zueoyesj	60	2	addition	addition	NN
cord-000248-zueoyesj	60	3	,	,	,
cord-000248-zueoyesj	60	4	as	as	IN
cord-000248-zueoyesj	60	5	a	a	DT
cord-000248-zueoyesj	60	6	mathematical	mathematical	JJ
cord-000248-zueoyesj	60	7	methodology	methodology	NN
cord-000248-zueoyesj	60	8	,	,	,
cord-000248-zueoyesj	60	9	it	-PRON-	PRP
cord-000248-zueoyesj	60	10	can	can	MD
cord-000248-zueoyesj	60	11	be	be	VB
cord-000248-zueoyesj	60	12	applied	apply	VBN
cord-000248-zueoyesj	60	13	to	to	IN
cord-000248-zueoyesj	60	14	other	other	JJ
cord-000248-zueoyesj	60	15	high	high	JJ
cord-000248-zueoyesj	60	16	-	-	HYPH
cord-000248-zueoyesj	60	17	throughput	throughput	NN
cord-000248-zueoyesj	60	18	technologies	technology	NNS
cord-000248-zueoyesj	60	19	for	for	IN
cord-000248-zueoyesj	60	20	which	which	WDT
cord-000248-zueoyesj	60	21	a	a	DT
cord-000248-zueoyesj	60	22	probability	probability	NN
cord-000248-zueoyesj	60	23	distribution	distribution	NN
cord-000248-zueoyesj	60	24	function	function	NN
cord-000248-zueoyesj	60	25	of	of	IN
cord-000248-zueoyesj	60	26	observed	observed	JJ
cord-000248-zueoyesj	60	27	abundances	abundance	NNS
cord-000248-zueoyesj	60	28	has	have	VBZ
cord-000248-zueoyesj	60	29	been	be	VBN
cord-000248-zueoyesj	60	30	computed	compute	VBN
cord-000248-zueoyesj	60	31	.	.	.
cord-000248-zueoyesj	61	1	With	with	IN
cord-000248-zueoyesj	61	2	these	these	DT
cord-000248-zueoyesj	61	3	ideas	idea	NNS
cord-000248-zueoyesj	61	4	in	in	IN
cord-000248-zueoyesj	61	5	mind	mind	NN
cord-000248-zueoyesj	61	6	,	,	,
cord-000248-zueoyesj	61	7	we	-PRON-	PRP
cord-000248-zueoyesj	61	8	provide	provide	VBP
cord-000248-zueoyesj	61	9	a	a	DT
cord-000248-zueoyesj	61	10	'	'	``
cord-000248-zueoyesj	61	11	'	'	``
cord-000248-zueoyesj	61	12	transcriptomic	transcriptomic	NNP
cord-000248-zueoyesj	61	13	-	-	HYPH
cord-000248-zueoyesj	61	14	driven	drive	VBN
cord-000248-zueoyesj	61	15	'	'	''
cord-000248-zueoyesj	61	16	'	'	''
cord-000248-zueoyesj	61	17	method	method	NN
cord-000248-zueoyesj	61	18	revealing	reveal	VBG
cord-000248-zueoyesj	61	19	important	important	JJ
cord-000248-zueoyesj	61	20	biomarkers	biomarker	NNS
cord-000248-zueoyesj	61	21	for	for	IN
cord-000248-zueoyesj	61	22	cancer	cancer	NN
cord-000248-zueoyesj	61	23	progression	progression	NN
cord-000248-zueoyesj	61	24	a	a	DT
cord-000248-zueoyesj	61	25	direction	direction	NN
cord-000248-zueoyesj	61	26	of	of	IN
cord-000248-zueoyesj	61	27	time	time	NN
cord-000248-zueoyesj	61	28	for	for	IN
cord-000248-zueoyesj	61	29	which	which	WDT
cord-000248-zueoyesj	61	30	they	-PRON-	PRP
cord-000248-zueoyesj	61	31	are	be	VBP
cord-000248-zueoyesj	61	32	presented	present	VBN
cord-000248-zueoyesj	61	33	.	.	.
cord-000248-zueoyesj	62	1	The	the	DT
cord-000248-zueoyesj	62	2	method	method	NN
cord-000248-zueoyesj	62	3	,	,	,
cord-000248-zueoyesj	62	4	however	however	RB
cord-000248-zueoyesj	62	5	,	,	,
cord-000248-zueoyesj	62	6	is	be	VBZ
cord-000248-zueoyesj	62	7	generalizable	generalizable	JJ
cord-000248-zueoyesj	62	8	to	to	IN
cord-000248-zueoyesj	62	9	other	other	JJ
cord-000248-zueoyesj	62	10	type	type	NN
cord-000248-zueoyesj	62	11	of	of	IN
cord-000248-zueoyesj	62	12	high	high	JJ
cord-000248-zueoyesj	62	13	-	-	HYPH
cord-000248-zueoyesj	62	14	throughtput	throughtput	NN
cord-000248-zueoyesj	62	15	techonologies	techonologie	NNS
cord-000248-zueoyesj	62	16	(	(	-LRB-
cord-000248-zueoyesj	62	17	e.g.	e.g.	IN
cord-000248-zueoyesj	62	18	proteomic	proteomic	JJ
cord-000248-zueoyesj	62	19	studies	study	NNS
cord-000248-zueoyesj	62	20	)	)	-RRB-
cord-000248-zueoyesj	62	21	.	.	.
cord-000248-zueoyesj	63	1	We	-PRON-	PRP
cord-000248-zueoyesj	63	2	have	have	VBP
cord-000248-zueoyesj	63	3	chosen	choose	VBN
cord-000248-zueoyesj	63	4	two	two	CD
cord-000248-zueoyesj	63	5	types	type	NNS
cord-000248-zueoyesj	63	6	of	of	IN
cord-000248-zueoyesj	63	7	cancers	cancer	NNS
cord-000248-zueoyesj	63	8	to	to	TO
cord-000248-zueoyesj	63	9	study	study	VB
cord-000248-zueoyesj	63	10	which	which	WDT
cord-000248-zueoyesj	63	11	are	be	VBP
cord-000248-zueoyesj	63	12	almost	almost	RB
cord-000248-zueoyesj	63	13	at	at	IN
cord-000248-zueoyesj	63	14	the	the	DT
cord-000248-zueoyesj	63	15	antipodes	antipode	NNS
cord-000248-zueoyesj	63	16	in	in	IN
cord-000248-zueoyesj	63	17	terms	term	NNS
cord-000248-zueoyesj	63	18	of	of	IN
cord-000248-zueoyesj	63	19	progression	progression	NN
cord-000248-zueoyesj	63	20	rates	rate	NNS
cord-000248-zueoyesj	63	21	:	:	:
cord-000248-zueoyesj	63	22	prostate	prostate	NN
cord-000248-zueoyesj	63	23	cancer	cancer	NN
cord-000248-zueoyesj	63	24	and	and	CC
cord-000248-zueoyesj	63	25	melanoma	melanoma	NN
cord-000248-zueoyesj	63	26	.	.	.
cord-000248-zueoyesj	64	1	Prostate	prostate	NN
cord-000248-zueoyesj	64	2	cancer	cancer	NN
cord-000248-zueoyesj	64	3	progresses	progress	VBZ
cord-000248-zueoyesj	64	4	very	very	RB
cord-000248-zueoyesj	64	5	slowly	slowly	RB
cord-000248-zueoyesj	64	6	.	.	.
cord-000248-zueoyesj	65	1	Pathological	pathological	JJ
cord-000248-zueoyesj	65	2	samples	sample	NNS
cord-000248-zueoyesj	65	3	are	be	VBP
cord-000248-zueoyesj	65	4	common	common	JJ
cord-000248-zueoyesj	65	5	in	in	IN
cord-000248-zueoyesj	65	6	autopsies	autopsy	NNS
cord-000248-zueoyesj	65	7	of	of	IN
cord-000248-zueoyesj	65	8	men	man	NNS
cord-000248-zueoyesj	65	9	as	as	RB
cord-000248-zueoyesj	65	10	young	young	JJ
cord-000248-zueoyesj	65	11	as	as	IN
cord-000248-zueoyesj	65	12	20	20	CD
cord-000248-zueoyesj	65	13	years	year	NNS
cord-000248-zueoyesj	65	14	old	old	JJ
cord-000248-zueoyesj	65	15	.	.	.
cord-000248-zueoyesj	66	1	By	by	IN
cord-000248-zueoyesj	66	2	the	the	DT
cord-000248-zueoyesj	66	3	age	age	NN
cord-000248-zueoyesj	66	4	of	of	IN
cord-000248-zueoyesj	66	5	70	70	CD
cord-000248-zueoyesj	66	6	more	more	JJR
cord-000248-zueoyesj	66	7	than	than	IN
cord-000248-zueoyesj	66	8	80	80	CD
cord-000248-zueoyesj	66	9	%	%	NN
cord-000248-zueoyesj	66	10	of	of	IN
cord-000248-zueoyesj	66	11	men	man	NNS
cord-000248-zueoyesj	66	12	have	have	VBP
cord-000248-zueoyesj	66	13	these	these	DT
cord-000248-zueoyesj	66	14	alterations	alteration	NNS
cord-000248-zueoyesj	66	15	,	,	,
cord-000248-zueoyesj	66	16	a	a	DT
cord-000248-zueoyesj	66	17	fact	fact	NN
cord-000248-zueoyesj	66	18	that	that	IN
cord-000248-zueoyesj	66	19	already	already	RB
cord-000248-zueoyesj	66	20	shows	show	VBZ
cord-000248-zueoyesj	66	21	a	a	DT
cord-000248-zueoyesj	66	22	relationship	relationship	NN
cord-000248-zueoyesj	66	23	of	of	IN
cord-000248-zueoyesj	66	24	this	this	DT
cord-000248-zueoyesj	66	25	cancer	cancer	NN
cord-000248-zueoyesj	66	26	type	type	NN
cord-000248-zueoyesj	66	27	with	with	IN
cord-000248-zueoyesj	66	28	increasing	increase	VBG
cord-000248-zueoyesj	66	29	age	age	NN
cord-000248-zueoyesj	66	30	.	.	.
cord-000248-zueoyesj	67	1	The	the	DT
cord-000248-zueoyesj	67	2	clinical	clinical	JJ
cord-000248-zueoyesj	67	3	management	management	NN
cord-000248-zueoyesj	67	4	of	of	IN
cord-000248-zueoyesj	67	5	prostate	prostate	NN
cord-000248-zueoyesj	67	6	cancer	cancer	NN
cord-000248-zueoyesj	67	7	requires	require	VBZ
cord-000248-zueoyesj	67	8	the	the	DT
cord-000248-zueoyesj	67	9	identification	identification	NN
cord-000248-zueoyesj	67	10	of	of	IN
cord-000248-zueoyesj	67	11	the	the	DT
cord-000248-zueoyesj	67	12	so	so	RB
cord-000248-zueoyesj	67	13	-	-	HYPH
cord-000248-zueoyesj	67	14	called	call	VBN
cord-000248-zueoyesj	67	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	67	16	patterns	pattern	NNS
cord-000248-zueoyesj	67	17	in	in	IN
cord-000248-zueoyesj	67	18	the	the	DT
cord-000248-zueoyesj	67	19	biopsies	biopsy	NNS
cord-000248-zueoyesj	67	20	[	[	-LRB-
cord-000248-zueoyesj	67	21	40	40	CD
cord-000248-zueoyesj	67	22	]	]	-RRB-
cord-000248-zueoyesj	67	23	,	,	,
cord-000248-zueoyesj	67	24	which	which	WDT
cord-000248-zueoyesj	67	25	after	after	IN
cord-000248-zueoyesj	67	26	almost	almost	RB
cord-000248-zueoyesj	67	27	fifty	fifty	CD
cord-000248-zueoyesj	67	28	years	year	NNS
cord-000248-zueoyesj	67	29	is	be	VBZ
cord-000248-zueoyesj	67	30	still	still	RB
cord-000248-zueoyesj	67	31	'	'	``
cord-000248-zueoyesj	67	32	'	'	''
cord-000248-zueoyesj	67	33	the	the	DT
cord-000248-zueoyesj	67	34	sole	sole	JJ
cord-000248-zueoyesj	67	35	prostatic	prostatic	JJ
cord-000248-zueoyesj	67	36	carcinoma	carcinoma	NN
cord-000248-zueoyesj	67	37	grading	grading	NN
cord-000248-zueoyesj	67	38	system	system	NN
cord-000248-zueoyesj	67	39	recommended	recommend	VBN
cord-000248-zueoyesj	67	40	by	by	IN
cord-000248-zueoyesj	67	41	the	the	DT
cord-000248-zueoyesj	67	42	World	World	NNP
cord-000248-zueoyesj	67	43	Health	Health	NNP
cord-000248-zueoyesj	67	44	Organization	Organization	NNP
cord-000248-zueoyesj	67	45	'	'	''
cord-000248-zueoyesj	67	46	'	'	''
cord-000248-zueoyesj	67	47	.	.	.
cord-000248-zueoyesj	68	1	However	however	RB
cord-000248-zueoyesj	68	2	,	,	,
cord-000248-zueoyesj	68	3	undergrading	undergrading	NN
cord-000248-zueoyesj	68	4	,	,	,
cord-000248-zueoyesj	68	5	underdiagnosis	underdiagnosis	NNP
cord-000248-zueoyesj	68	6	,	,	,
cord-000248-zueoyesj	68	7	interobserver	interobserver	NN
cord-000248-zueoyesj	68	8	reproducibility	reproducibility	NN
cord-000248-zueoyesj	68	9	and	and	CC
cord-000248-zueoyesj	68	10	variable	variable	JJ
cord-000248-zueoyesj	68	11	trends	trend	NNS
cord-000248-zueoyesj	68	12	in	in	IN
cord-000248-zueoyesj	68	13	grading	grading	NN
cord-000248-zueoyesj	68	14	have	have	VBP
cord-000248-zueoyesj	68	15	been	be	VBN
cord-000248-zueoyesj	68	16	observed	observe	VBN
cord-000248-zueoyesj	68	17	as	as	IN
cord-000248-zueoyesj	68	18	major	major	JJ
cord-000248-zueoyesj	68	19	problems	problem	NNS
cord-000248-zueoyesj	68	20	[	[	-LRB-
cord-000248-zueoyesj	68	21	41	41	CD
cord-000248-zueoyesj	68	22	,	,	,
cord-000248-zueoyesj	68	23	42	42	CD
cord-000248-zueoyesj	68	24	]	]	-RRB-
cord-000248-zueoyesj	68	25	.	.	.
cord-000248-zueoyesj	69	1	Melanoma	melanoma	NN
cord-000248-zueoyesj	69	2	,	,	,
cord-000248-zueoyesj	69	3	on	on	IN
cord-000248-zueoyesj	69	4	the	the	DT
cord-000248-zueoyesj	69	5	other	other	JJ
cord-000248-zueoyesj	69	6	hand	hand	NN
cord-000248-zueoyesj	69	7	,	,	,
cord-000248-zueoyesj	69	8	differs	differ	VBZ
cord-000248-zueoyesj	69	9	from	from	IN
cord-000248-zueoyesj	69	10	prostate	prostate	NN
cord-000248-zueoyesj	69	11	cancer	cancer	NN
cord-000248-zueoyesj	69	12	in	in	IN
cord-000248-zueoyesj	69	13	its	-PRON-	PRP$
cord-000248-zueoyesj	69	14	rapid	rapid	JJ
cord-000248-zueoyesj	69	15	progression	progression	NN
cord-000248-zueoyesj	69	16	[	[	-LRB-
cord-000248-zueoyesj	69	17	43	43	CD
cord-000248-zueoyesj	69	18	]	]	-RRB-
cord-000248-zueoyesj	69	19	and	and	CC
cord-000248-zueoyesj	69	20	it	-PRON-	PRP
cord-000248-zueoyesj	69	21	is	be	VBZ
cord-000248-zueoyesj	69	22	considered	consider	VBN
cord-000248-zueoyesj	69	23	one	one	CD
cord-000248-zueoyesj	69	24	of	of	IN
cord-000248-zueoyesj	69	25	the	the	DT
cord-000248-zueoyesj	69	26	most	most	RBS
cord-000248-zueoyesj	69	27	aggressive	aggressive	JJ
cord-000248-zueoyesj	69	28	types	type	NNS
cord-000248-zueoyesj	69	29	of	of	IN
cord-000248-zueoyesj	69	30	cancer	cancer	NN
cord-000248-zueoyesj	69	31	.	.	.
cord-000248-zueoyesj	70	1	One	one	CD
cord-000248-zueoyesj	70	2	of	of	IN
cord-000248-zueoyesj	70	3	melanoma	melanoma	NN
cord-000248-zueoyesj	70	4	's	's	POS
cord-000248-zueoyesj	70	5	usual	usual	JJ
cord-000248-zueoyesj	70	6	markers	marker	NNS
cord-000248-zueoyesj	70	7	of	of	IN
cord-000248-zueoyesj	70	8	progression	progression	NN
cord-000248-zueoyesj	70	9	and	and	CC
cord-000248-zueoyesj	70	10	concern	concern	NN
cord-000248-zueoyesj	70	11	(	(	-LRB-
cord-000248-zueoyesj	70	12	i.e	i.e	IN
cord-000248-zueoyesj	70	13	thickness	thickness	NN
cord-000248-zueoyesj	70	14	)	)	-RRB-
cord-000248-zueoyesj	70	15	is	be	VBZ
cord-000248-zueoyesj	70	16	measured	measure	VBN
cord-000248-zueoyesj	70	17	in	in	IN
cord-000248-zueoyesj	70	18	millimetres	millimetre	NNS
cord-000248-zueoyesj	70	19	,	,	,
cord-000248-zueoyesj	70	20	which	which	WDT
cord-000248-zueoyesj	70	21	gives	give	VBZ
cord-000248-zueoyesj	70	22	a	a	DT
cord-000248-zueoyesj	70	23	rough	rough	JJ
cord-000248-zueoyesj	70	24	idea	idea	NN
cord-000248-zueoyesj	70	25	of	of	IN
cord-000248-zueoyesj	70	26	how	how	WRB
cord-000248-zueoyesj	70	27	devastatingly	devastatingly	RB
cord-000248-zueoyesj	70	28	fast	fast	JJ
cord-000248-zueoyesj	70	29	the	the	DT
cord-000248-zueoyesj	70	30	disease	disease	NN
cord-000248-zueoyesj	70	31	can	can	MD
cord-000248-zueoyesj	70	32	spread	spread	VB
cord-000248-zueoyesj	70	33	.	.	.
cord-000248-zueoyesj	71	1	We	-PRON-	PRP
cord-000248-zueoyesj	71	2	will	will	MD
cord-000248-zueoyesj	71	3	present	present	VB
cord-000248-zueoyesj	71	4	our	-PRON-	PRP$
cord-000248-zueoyesj	71	5	results	result	NNS
cord-000248-zueoyesj	71	6	starting	start	VBG
cord-000248-zueoyesj	71	7	with	with	IN
cord-000248-zueoyesj	71	8	one	one	CD
cord-000248-zueoyesj	71	9	prostate	prostate	NN
cord-000248-zueoyesj	71	10	cancer	cancer	NN
cord-000248-zueoyesj	71	11	dataset	dataset	NN
cord-000248-zueoyesj	71	12	,	,	,
cord-000248-zueoyesj	71	13	followed	follow	VBN
cord-000248-zueoyesj	71	14	by	by	IN
cord-000248-zueoyesj	71	15	another	another	DT
cord-000248-zueoyesj	71	16	in	in	IN
cord-000248-zueoyesj	71	17	melanoma	melanoma	NN
cord-000248-zueoyesj	71	18	,	,	,
cord-000248-zueoyesj	71	19	to	to	TO
cord-000248-zueoyesj	71	20	come	come	VB
cord-000248-zueoyesj	71	21	back	back	RB
cord-000248-zueoyesj	71	22	to	to	IN
cord-000248-zueoyesj	71	23	the	the	DT
cord-000248-zueoyesj	71	24	prostate	prostate	NN
cord-000248-zueoyesj	71	25	cancer	cancer	NN
cord-000248-zueoyesj	71	26	discussion	discussion	NN
cord-000248-zueoyesj	71	27	using	use	VBG
cord-000248-zueoyesj	71	28	another	another	DT
cord-000248-zueoyesj	71	29	highly	highly	RB
cord-000248-zueoyesj	71	30	relevant	relevant	JJ
cord-000248-zueoyesj	71	31	dataset	dataset	NN
cord-000248-zueoyesj	71	32	.	.	.
cord-000248-zueoyesj	72	1	This	this	DT
cord-000248-zueoyesj	72	2	is	be	VBZ
cord-000248-zueoyesj	72	3	a	a	DT
cord-000248-zueoyesj	72	4	departure	departure	NN
cord-000248-zueoyesj	72	5	from	from	IN
cord-000248-zueoyesj	72	6	the	the	DT
cord-000248-zueoyesj	72	7	alternative	alternative	JJ
cord-000248-zueoyesj	72	8	approach	approach	NN
cord-000248-zueoyesj	72	9	in	in	IN
cord-000248-zueoyesj	72	10	which	which	WDT
cord-000248-zueoyesj	72	11	each	each	DT
cord-000248-zueoyesj	72	12	disease	disease	NN
cord-000248-zueoyesj	72	13	is	be	VBZ
cord-000248-zueoyesj	72	14	discussed	discuss	VBN
cord-000248-zueoyesj	72	15	in	in	IN
cord-000248-zueoyesj	72	16	separate	separate	JJ
cord-000248-zueoyesj	72	17	sections	section	NNS
cord-000248-zueoyesj	72	18	.	.	.
cord-000248-zueoyesj	73	1	However	however	RB
cord-000248-zueoyesj	73	2	,	,	,
cord-000248-zueoyesj	73	3	after	after	IN
cord-000248-zueoyesj	73	4	considering	consider	VBG
cord-000248-zueoyesj	73	5	several	several	JJ
cord-000248-zueoyesj	73	6	possibilities	possibility	NNS
cord-000248-zueoyesj	73	7	,	,	,
cord-000248-zueoyesj	73	8	we	-PRON-	PRP
cord-000248-zueoyesj	73	9	are	be	VBP
cord-000248-zueoyesj	73	10	convinced	convinced	JJ
cord-000248-zueoyesj	73	11	that	that	IN
cord-000248-zueoyesj	73	12	our	-PRON-	PRP$
cord-000248-zueoyesj	73	13	approach	approach	NN
cord-000248-zueoyesj	73	14	is	be	VBZ
cord-000248-zueoyesj	73	15	the	the	DT
cord-000248-zueoyesj	73	16	most	most	RBS
cord-000248-zueoyesj	73	17	appropriate	appropriate	JJ
cord-000248-zueoyesj	73	18	to	to	TO
cord-000248-zueoyesj	73	19	showcase	showcase	VB
cord-000248-zueoyesj	73	20	the	the	DT
cord-000248-zueoyesj	73	21	technique	technique	NN
cord-000248-zueoyesj	73	22	and	and	CC
cord-000248-zueoyesj	73	23	its	-PRON-	PRP$
cord-000248-zueoyesj	73	24	power	power	NN
cord-000248-zueoyesj	73	25	.	.	.
cord-000248-zueoyesj	74	1	Details	detail	NNS
cord-000248-zueoyesj	74	2	on	on	IN
cord-000248-zueoyesj	74	3	the	the	DT
cord-000248-zueoyesj	74	4	datasets	dataset	NNS
cord-000248-zueoyesj	74	5	and	and	CC
cord-000248-zueoyesj	74	6	methods	method	NNS
cord-000248-zueoyesj	74	7	used	use	VBN
cord-000248-zueoyesj	74	8	are	be	VBP
cord-000248-zueoyesj	74	9	given	give	VBN
cord-000248-zueoyesj	74	10	in	in	IN
cord-000248-zueoyesj	74	11	the	the	DT
cord-000248-zueoyesj	74	12	'	'	``
cord-000248-zueoyesj	74	13	Materials	material	NNS
cord-000248-zueoyesj	74	14	and	and	CC
cord-000248-zueoyesj	74	15	Methods	Methods	NNPS
cord-000248-zueoyesj	74	16	'	'	POS
cord-000248-zueoyesj	74	17	section	section	NN
cord-000248-zueoyesj	74	18	of	of	IN
cord-000248-zueoyesj	74	19	this	this	DT
cord-000248-zueoyesj	74	20	paper	paper	NN
cord-000248-zueoyesj	74	21	.	.	.
cord-000248-zueoyesj	75	1	We	-PRON-	PRP
cord-000248-zueoyesj	75	2	also	also	RB
cord-000248-zueoyesj	75	3	refer	refer	VBP
cord-000248-zueoyesj	75	4	to	to	IN
cord-000248-zueoyesj	75	5	the	the	DT
cord-000248-zueoyesj	75	6	original	original	JJ
cord-000248-zueoyesj	75	7	studies	study	NNS
cord-000248-zueoyesj	75	8	and	and	CC
cord-000248-zueoyesj	75	9	manuscripts	manuscript	NNS
cord-000248-zueoyesj	75	10	associated	associate	VBN
cord-000248-zueoyesj	75	11	to	to	IN
cord-000248-zueoyesj	75	12	the	the	DT
cord-000248-zueoyesj	75	13	three	three	CD
cord-000248-zueoyesj	75	14	datasets	dataset	NNS
cord-000248-zueoyesj	75	15	we	-PRON-	PRP
cord-000248-zueoyesj	75	16	analysed	analyse	VBD
cord-000248-zueoyesj	75	17	.	.	.
cord-000248-zueoyesj	76	1	and	and	CC
cord-000248-zueoyesj	76	2	available	available	JJ
cord-000248-zueoyesj	76	3	at	at	IN
cord-000248-zueoyesj	76	4	the	the	DT
cord-000248-zueoyesj	76	5	web	web	NN
cord-000248-zueoyesj	76	6	address	address	NN
cord-000248-zueoyesj	76	7	given	give	VBN
cord-000248-zueoyesj	76	8	above	above	RB
cord-000248-zueoyesj	76	9	)	)	-RRB-
cord-000248-zueoyesj	76	10	.	.	.
cord-000248-zueoyesj	77	1	After	after	IN
cord-000248-zueoyesj	77	2	imputation	imputation	NN
cord-000248-zueoyesj	77	3	of	of	IN
cord-000248-zueoyesj	77	4	missing	miss	VBG
cord-000248-zueoyesj	77	5	values	value	NNS
cord-000248-zueoyesj	77	6	,	,	,
cord-000248-zueoyesj	77	7	we	-PRON-	PRP
cord-000248-zueoyesj	77	8	first	first	RB
cord-000248-zueoyesj	77	9	calculated	calculate	VBD
cord-000248-zueoyesj	77	10	the	the	DT
cord-000248-zueoyesj	77	11	Normalized	Normalized	NNP
cord-000248-zueoyesj	77	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	77	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	77	14	and	and	CC
cord-000248-zueoyesj	77	15	the	the	DT
cord-000248-zueoyesj	77	16	MPR	MPR	NNP
cord-000248-zueoyesj	77	17	-	-	HYPH
cord-000248-zueoyesj	77	18	Statistical	Statistical	NNP
cord-000248-zueoyesj	77	19	Complexity	Complexity	NNP
cord-000248-zueoyesj	77	20	for	for	IN
cord-000248-zueoyesj	77	21	the	the	DT
cord-000248-zueoyesj	77	22	each	each	DT
cord-000248-zueoyesj	77	23	sample	sample	NN
cord-000248-zueoyesj	77	24	.	.	.
cord-000248-zueoyesj	78	1	The	the	DT
cord-000248-zueoyesj	78	2	flowing	flow	VBG
cord-000248-zueoyesj	78	3	section	section	NN
cord-000248-zueoyesj	78	4	explains	explain	VBZ
cord-000248-zueoyesj	78	5	the	the	DT
cord-000248-zueoyesj	78	6	context	context	NN
cord-000248-zueoyesj	78	7	in	in	IN
cord-000248-zueoyesj	78	8	which	which	WDT
cord-000248-zueoyesj	78	9	our	-PRON-	PRP$
cord-000248-zueoyesj	78	10	results	result	NNS
cord-000248-zueoyesj	78	11	were	be	VBD
cord-000248-zueoyesj	78	12	generated	generate	VBN
cord-000248-zueoyesj	78	13	(	(	-LRB-
cord-000248-zueoyesj	78	14	refer	refer	VB
cord-000248-zueoyesj	78	15	to	to	IN
cord-000248-zueoyesj	78	16	the	the	DT
cord-000248-zueoyesj	78	17	'	'	``
cord-000248-zueoyesj	78	18	Materials	material	NNS
cord-000248-zueoyesj	78	19	and	and	CC
cord-000248-zueoyesj	78	20	Methods	Methods	NNPS
cord-000248-zueoyesj	78	21	'	'	POS
cord-000248-zueoyesj	78	22	section	section	NN
cord-000248-zueoyesj	78	23	for	for	IN
cord-000248-zueoyesj	78	24	detail	detail	NN
cord-000248-zueoyesj	78	25	on	on	IN
cord-000248-zueoyesj	78	26	how	how	WRB
cord-000248-zueoyesj	78	27	our	-PRON-	PRP$
cord-000248-zueoyesj	78	28	quantities	quantity	NNS
cord-000248-zueoyesj	78	29	are	be	VBP
cord-000248-zueoyesj	78	30	computed	compute	VBN
cord-000248-zueoyesj	78	31	)	)	-RRB-
cord-000248-zueoyesj	78	32	.	.	.
cord-000248-zueoyesj	79	1	The	the	DT
cord-000248-zueoyesj	79	2	Normalized	Normalized	NNP
cord-000248-zueoyesj	79	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	79	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	79	5	measure	measure	NN
cord-000248-zueoyesj	79	6	is	be	VBZ
cord-000248-zueoyesj	79	7	widely	widely	RB
cord-000248-zueoyesj	79	8	used	use	VBN
cord-000248-zueoyesj	79	9	in	in	IN
cord-000248-zueoyesj	79	10	ecosystem	ecosystem	NN
cord-000248-zueoyesj	79	11	modelling	modelling	NN
cord-000248-zueoyesj	79	12	to	to	TO
cord-000248-zueoyesj	79	13	quantify	quantify	VB
cord-000248-zueoyesj	79	14	species	specie	NNS
cord-000248-zueoyesj	79	15	diversity	diversity	NN
cord-000248-zueoyesj	79	16	,	,	,
cord-000248-zueoyesj	79	17	where	where	WRB
cord-000248-zueoyesj	79	18	it	-PRON-	PRP
cord-000248-zueoyesj	79	19	is	be	VBZ
cord-000248-zueoyesj	79	20	acknowledge	acknowledge	VBN
cord-000248-zueoyesj	79	21	as	as	IN
cord-000248-zueoyesj	79	22	having	have	VBG
cord-000248-zueoyesj	79	23	great	great	JJ
cord-000248-zueoyesj	79	24	sensitivity	sensitivity	NN
cord-000248-zueoyesj	79	25	to	to	IN
cord-000248-zueoyesj	79	26	relative	relative	JJ
cord-000248-zueoyesj	79	27	abundances	abundance	NNS
cord-000248-zueoyesj	79	28	of	of	IN
cord-000248-zueoyesj	79	29	species	specie	NNS
cord-000248-zueoyesj	79	30	in	in	IN
cord-000248-zueoyesj	79	31	an	an	DT
cord-000248-zueoyesj	79	32	ecosystem	ecosystem	NN
cord-000248-zueoyesj	79	33	[	[	-LRB-
cord-000248-zueoyesj	79	34	45	45	CD
cord-000248-zueoyesj	79	35	]	]	-RRB-
cord-000248-zueoyesj	79	36	.	.	.
cord-000248-zueoyesj	80	1	We	-PRON-	PRP
cord-000248-zueoyesj	80	2	utilise	utilise	VBP
cord-000248-zueoyesj	80	3	the	the	DT
cord-000248-zueoyesj	80	4	same	same	JJ
cord-000248-zueoyesj	80	5	sensitivity	sensitivity	NN
cord-000248-zueoyesj	80	6	to	to	TO
cord-000248-zueoyesj	80	7	differentiate	differentiate	VB
cord-000248-zueoyesj	80	8	a	a	DT
cord-000248-zueoyesj	80	9	samples	sample	NNS
cord-000248-zueoyesj	80	10	in	in	IN
cord-000248-zueoyesj	80	11	cancer	cancer	NN
cord-000248-zueoyesj	80	12	datasets	dataset	NNS
cord-000248-zueoyesj	80	13	.	.	.
cord-000248-zueoyesj	81	1	Figure	figure	NN
cord-000248-zueoyesj	81	2	1	1	CD
cord-000248-zueoyesj	81	3	shows	show	VBZ
cord-000248-zueoyesj	81	4	that	that	IN
cord-000248-zueoyesj	81	5	the	the	DT
cord-000248-zueoyesj	81	6	Normalized	Normalized	NNP
cord-000248-zueoyesj	81	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	81	8	Entropy	Entropy	NNP
cord-000248-zueoyesj	81	9	of	of	IN
cord-000248-zueoyesj	81	10	prostate	prostate	NN
cord-000248-zueoyesj	81	11	cancer	cancer	NN
cord-000248-zueoyesj	81	12	tumor	tumor	NN
cord-000248-zueoyesj	81	13	samples	sample	NNS
cord-000248-zueoyesj	81	14	do	do	VBP
cord-000248-zueoyesj	81	15	not	not	RB
cord-000248-zueoyesj	81	16	differ	differ	VB
cord-000248-zueoyesj	81	17	much	much	RB
cord-000248-zueoyesj	81	18	from	from	IN
cord-000248-zueoyesj	81	19	normal	normal	JJ
cord-000248-zueoyesj	81	20	samples	sample	NNS
cord-000248-zueoyesj	81	21	.	.	.
cord-000248-zueoyesj	82	1	This	this	DT
cord-000248-zueoyesj	82	2	is	be	VBZ
cord-000248-zueoyesj	82	3	in	in	IN
cord-000248-zueoyesj	82	4	contrast	contrast	NN
cord-000248-zueoyesj	82	5	to	to	IN
cord-000248-zueoyesj	82	6	lymph	lymph	NN
cord-000248-zueoyesj	82	7	node	node	NN
cord-000248-zueoyesj	82	8	metastasis	metastasis	NN
cord-000248-zueoyesj	82	9	samples	sample	NNS
cord-000248-zueoyesj	82	10	that	that	WDT
cord-000248-zueoyesj	82	11	appear	appear	VBP
cord-000248-zueoyesj	82	12	to	to	TO
cord-000248-zueoyesj	82	13	have	have	VB
cord-000248-zueoyesj	82	14	smaller	small	JJR
cord-000248-zueoyesj	82	15	values	value	NNS
cord-000248-zueoyesj	82	16	of	of	IN
cord-000248-zueoyesj	82	17	Normalized	Normalized	NNP
cord-000248-zueoyesj	82	18	Shannon	Shannon	NNP
cord-000248-zueoyesj	82	19	Entropy	Entropy	NNP
cord-000248-zueoyesj	82	20	.	.	.
cord-000248-zueoyesj	83	1	A	a	DT
cord-000248-zueoyesj	83	2	mathematical	mathematical	JJ
cord-000248-zueoyesj	83	3	interpretation	interpretation	NN
cord-000248-zueoyesj	83	4	of	of	IN
cord-000248-zueoyesj	83	5	this	this	DT
cord-000248-zueoyesj	83	6	result	result	NN
cord-000248-zueoyesj	83	7	is	be	VBZ
cord-000248-zueoyesj	83	8	that	that	IN
cord-000248-zueoyesj	83	9	the	the	DT
cord-000248-zueoyesj	83	10	samples	sample	NNS
cord-000248-zueoyesj	83	11	from	from	IN
cord-000248-zueoyesj	83	12	lymph	lymph	NN
cord-000248-zueoyesj	83	13	node	node	NN
cord-000248-zueoyesj	83	14	metastases	metastasis	NNS
cord-000248-zueoyesj	83	15	have	have	VBP
cord-000248-zueoyesj	83	16	cells	cell	NNS
cord-000248-zueoyesj	83	17	that	that	WDT
cord-000248-zueoyesj	83	18	not	not	RB
cord-000248-zueoyesj	83	19	only	only	RB
cord-000248-zueoyesj	83	20	varied	vary	VBD
cord-000248-zueoyesj	83	21	their	-PRON-	PRP$
cord-000248-zueoyesj	83	22	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	83	23	profile	profile	NN
cord-000248-zueoyesj	83	24	,	,	,
cord-000248-zueoyesj	83	25	they	-PRON-	PRP
cord-000248-zueoyesj	83	26	have	have	VBP
cord-000248-zueoyesj	83	27	also	also	RB
cord-000248-zueoyesj	83	28	'	'	''
cord-000248-zueoyesj	83	29	'	'	''
cord-000248-zueoyesj	83	30	peaked	peak	VBD
cord-000248-zueoyesj	83	31	'	'	''
cord-000248-zueoyesj	83	32	'	'	''
cord-000248-zueoyesj	83	33	the	the	DT
cord-000248-zueoyesj	83	34	distribution	distribution	NN
cord-000248-zueoyesj	83	35	of	of	IN
cord-000248-zueoyesj	83	36	expression	expression	NN
cord-000248-zueoyesj	83	37	values	value	NNS
cord-000248-zueoyesj	83	38	with	with	IN
cord-000248-zueoyesj	83	39	significant	significant	JJ
cord-000248-zueoyesj	83	40	fold	fold	JJ
cord-000248-zueoyesj	83	41	increases	increase	NNS
cord-000248-zueoyesj	83	42	on	on	IN
cord-000248-zueoyesj	83	43	a	a	DT
cord-000248-zueoyesj	83	44	smaller	small	JJR
cord-000248-zueoyesj	83	45	number	number	NN
cord-000248-zueoyesj	83	46	of	of	IN
cord-000248-zueoyesj	83	47	probes	probe	NNS
cord-000248-zueoyesj	83	48	.	.	.
cord-000248-zueoyesj	84	1	This	this	DT
cord-000248-zueoyesj	84	2	explains	explain	VBZ
cord-000248-zueoyesj	84	3	the	the	DT
cord-000248-zueoyesj	84	4	reduction	reduction	NN
cord-000248-zueoyesj	84	5	in	in	IN
cord-000248-zueoyesj	84	6	Normalized	Normalized	NNP
cord-000248-zueoyesj	84	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	84	8	Entropy	Entropy	NNP
cord-000248-zueoyesj	84	9	.	.	.
cord-000248-zueoyesj	85	1	We	-PRON-	PRP
cord-000248-zueoyesj	85	2	note	note	VBP
cord-000248-zueoyesj	85	3	that	that	IN
cord-000248-zueoyesj	85	4	there	there	EX
cord-000248-zueoyesj	85	5	are	be	VBP
cord-000248-zueoyesj	85	6	several	several	JJ
cord-000248-zueoyesj	85	7	mechanisms	mechanism	NNS
cord-000248-zueoyesj	85	8	that	that	WDT
cord-000248-zueoyesj	85	9	can	can	MD
cord-000248-zueoyesj	85	10	explain	explain	VB
cord-000248-zueoyesj	85	11	a	a	DT
cord-000248-zueoyesj	85	12	macroscopically	macroscopically	RB
cord-000248-zueoyesj	85	13	observable	observable	JJ
cord-000248-zueoyesj	85	14	global	global	JJ
cord-000248-zueoyesj	85	15	reduction	reduction	NN
cord-000248-zueoyesj	85	16	of	of	IN
cord-000248-zueoyesj	85	17	transcription	transcription	NN
cord-000248-zueoyesj	85	18	.	.	.
cord-000248-zueoyesj	86	1	For	for	IN
cord-000248-zueoyesj	86	2	instance	instance	NN
cord-000248-zueoyesj	86	3	,	,	,
cord-000248-zueoyesj	86	4	this	this	DT
cord-000248-zueoyesj	86	5	may	may	MD
cord-000248-zueoyesj	86	6	indicate	indicate	VB
cord-000248-zueoyesj	86	7	that	that	IN
cord-000248-zueoyesj	86	8	a	a	DT
cord-000248-zueoyesj	86	9	relatively	relatively	RB
cord-000248-zueoyesj	86	10	large	large	JJ
cord-000248-zueoyesj	86	11	number	number	NN
cord-000248-zueoyesj	86	12	of	of	IN
cord-000248-zueoyesj	86	13	genes	gene	NNS
cord-000248-zueoyesj	86	14	have	have	VBP
cord-000248-zueoyesj	86	15	reduced	reduce	VBN
cord-000248-zueoyesj	86	16	their	-PRON-	PRP$
cord-000248-zueoyesj	86	17	expression	expression	NN
cord-000248-zueoyesj	86	18	levels	level	NNS
cord-000248-zueoyesj	86	19	by	by	IN
cord-000248-zueoyesj	86	20	genome	genome	NN
cord-000248-zueoyesj	86	21	damage	damage	NN
cord-000248-zueoyesj	86	22	,	,	,
cord-000248-zueoyesj	86	23	changes	change	NNS
cord-000248-zueoyesj	86	24	in	in	IN
cord-000248-zueoyesj	86	25	gene	gene	NN
cord-000248-zueoyesj	86	26	regulation	regulation	NN
cord-000248-zueoyesj	86	27	,	,	,
cord-000248-zueoyesj	86	28	or	or	CC
cord-000248-zueoyesj	86	29	other	other	JJ
cord-000248-zueoyesj	86	30	silencing	silencing	NN
cord-000248-zueoyesj	86	31	processes	process	NNS
cord-000248-zueoyesj	86	32	.	.	.
cord-000248-zueoyesj	87	1	It	-PRON-	PRP
cord-000248-zueoyesj	87	2	is	be	VBZ
cord-000248-zueoyesj	87	3	reassuring	reassure	VBG
cord-000248-zueoyesj	87	4	to	to	TO
cord-000248-zueoyesj	87	5	observe	observe	VB
cord-000248-zueoyesj	87	6	that	that	IN
cord-000248-zueoyesj	87	7	the	the	DT
cord-000248-zueoyesj	87	8	changes	change	NNS
cord-000248-zueoyesj	87	9	of	of	IN
cord-000248-zueoyesj	87	10	the	the	DT
cord-000248-zueoyesj	87	11	most	most	RBS
cord-000248-zueoyesj	87	12	prototypical	prototypical	JJ
cord-000248-zueoyesj	87	13	quantitative	quantitative	JJ
cord-000248-zueoyesj	87	14	measure	measure	NN
cord-000248-zueoyesj	87	15	we	-PRON-	PRP
cord-000248-zueoyesj	87	16	can	can	MD
cord-000248-zueoyesj	87	17	draw	draw	VB
cord-000248-zueoyesj	87	18	from	from	IN
cord-000248-zueoyesj	87	19	Information	Information	NNP
cord-000248-zueoyesj	87	20	Theory	Theory	NNP
cord-000248-zueoyesj	87	21	,	,	,
cord-000248-zueoyesj	87	22	the	the	DT
cord-000248-zueoyesj	87	23	Normalized	Normalized	NNP
cord-000248-zueoyesj	87	24	Shannon	Shannon	NNP
cord-000248-zueoyesj	87	25	Entropy	Entropy	NNP
cord-000248-zueoyesj	87	26	correlate	correlate	VBP
cord-000248-zueoyesj	87	27	well	well	RB
cord-000248-zueoyesj	87	28	with	with	IN
cord-000248-zueoyesj	87	29	the	the	DT
cord-000248-zueoyesj	87	30	transition	transition	NN
cord-000248-zueoyesj	87	31	between	between	IN
cord-000248-zueoyesj	87	32	normal	normal	JJ
cord-000248-zueoyesj	87	33	samples	sample	NNS
cord-000248-zueoyesj	87	34	with	with	IN
cord-000248-zueoyesj	87	35	to	to	IN
cord-000248-zueoyesj	87	36	ones	one	NNS
cord-000248-zueoyesj	87	37	with	with	IN
cord-000248-zueoyesj	87	38	metastases	metastasis	NNS
cord-000248-zueoyesj	87	39	.	.	.
cord-000248-zueoyesj	88	1	However	however	RB
cord-000248-zueoyesj	88	2	,	,	,
cord-000248-zueoyesj	88	3	it	-PRON-	PRP
cord-000248-zueoyesj	88	4	is	be	VBZ
cord-000248-zueoyesj	88	5	also	also	RB
cord-000248-zueoyesj	88	6	evident	evident	JJ
cord-000248-zueoyesj	88	7	from	from	IN
cord-000248-zueoyesj	88	8	that	that	DT
cord-000248-zueoyesj	88	9	normal	normal	JJ
cord-000248-zueoyesj	88	10	samples	sample	NNS
cord-000248-zueoyesj	88	11	do	do	VBP
cord-000248-zueoyesj	88	12	not	not	RB
cord-000248-zueoyesj	88	13	differentiate	differentiate	VB
cord-000248-zueoyesj	88	14	much	much	JJ
cord-000248-zueoyesj	88	15	from	from	IN
cord-000248-zueoyesj	88	16	the	the	DT
cord-000248-zueoyesj	88	17	tumor	tumor	NN
cord-000248-zueoyesj	88	18	group	group	NN
cord-000248-zueoyesj	88	19	(	(	-LRB-
cord-000248-zueoyesj	88	20	the	the	DT
cord-000248-zueoyesj	88	21	Normalized	Normalized	NNP
cord-000248-zueoyesj	88	22	Shannon	Shannon	NNP
cord-000248-zueoyesj	88	23	Entropy	Entropy	NNP
cord-000248-zueoyesj	88	24	values	value	NNS
cord-000248-zueoyesj	88	25	do	do	VBP
cord-000248-zueoyesj	88	26	not	not	RB
cord-000248-zueoyesj	88	27	differ	differ	VB
cord-000248-zueoyesj	88	28	much	much	RB
cord-000248-zueoyesj	88	29	)	)	-RRB-
cord-000248-zueoyesj	88	30	.	.	.
cord-000248-zueoyesj	89	1	It	-PRON-	PRP
cord-000248-zueoyesj	89	2	is	be	VBZ
cord-000248-zueoyesj	89	3	then	then	RB
cord-000248-zueoyesj	89	4	not	not	RB
cord-000248-zueoyesj	89	5	the	the	DT
cord-000248-zueoyesj	89	6	number	number	NN
cord-000248-zueoyesj	89	7	of	of	IN
cord-000248-zueoyesj	89	8	genes	gene	NNS
cord-000248-zueoyesj	89	9	with	with	IN
cord-000248-zueoyesj	89	10	high	high	JJ
cord-000248-zueoyesj	89	11	expression	expression	NN
cord-000248-zueoyesj	89	12	values	value	NNS
cord-000248-zueoyesj	89	13	,	,	,
cord-000248-zueoyesj	89	14	but	but	CC
cord-000248-zueoyesj	89	15	the	the	DT
cord-000248-zueoyesj	89	16	change	change	NN
cord-000248-zueoyesj	89	17	in	in	IN
cord-000248-zueoyesj	89	18	the	the	DT
cord-000248-zueoyesj	89	19	distribution	distribution	NN
cord-000248-zueoyesj	89	20	of	of	IN
cord-000248-zueoyesj	89	21	expression	expression	NN
cord-000248-zueoyesj	89	22	levels	level	NNS
cord-000248-zueoyesj	89	23	on	on	IN
cord-000248-zueoyesj	89	24	the	the	DT
cord-000248-zueoyesj	89	25	molecular	molecular	JJ
cord-000248-zueoyesj	89	26	profile	profile	NN
cord-000248-zueoyesj	89	27	,	,	,
cord-000248-zueoyesj	89	28	that	that	WDT
cord-000248-zueoyesj	89	29	can	can	MD
cord-000248-zueoyesj	89	30	provide	provide	VB
cord-000248-zueoyesj	89	31	the	the	DT
cord-000248-zueoyesj	89	32	other	other	JJ
cord-000248-zueoyesj	89	33	measure	measure	NN
cord-000248-zueoyesj	89	34	that	that	WDT
cord-000248-zueoyesj	89	35	could	could	MD
cord-000248-zueoyesj	89	36	distinguish	distinguish	VB
cord-000248-zueoyesj	89	37	these	these	DT
cord-000248-zueoyesj	89	38	other	other	JJ
cord-000248-zueoyesj	89	39	samples	sample	NNS
cord-000248-zueoyesj	89	40	.	.	.
cord-000248-zueoyesj	90	1	This	this	DT
cord-000248-zueoyesj	90	2	must	must	MD
cord-000248-zueoyesj	90	3	be	be	VB
cord-000248-zueoyesj	90	4	handled	handle	VBN
cord-000248-zueoyesj	90	5	by	by	IN
cord-000248-zueoyesj	90	6	the	the	DT
cord-000248-zueoyesj	90	7	other	other	JJ
cord-000248-zueoyesj	90	8	statistical	statistical	JJ
cord-000248-zueoyesj	90	9	complexity	complexity	NN
cord-000248-zueoyesj	90	10	measures	measure	NNS
cord-000248-zueoyesj	90	11	to	to	TO
cord-000248-zueoyesj	90	12	be	be	VB
cord-000248-zueoyesj	90	13	discussed	discuss	VBN
cord-000248-zueoyesj	90	14	next	next	RB
cord-000248-zueoyesj	90	15	.	.	.
cord-000248-zueoyesj	91	1	Several	several	JJ
cord-000248-zueoyesj	91	2	statistical	statistical	JJ
cord-000248-zueoyesj	91	3	complexity	complexity	NN
cord-000248-zueoyesj	91	4	measures	measure	NNS
cord-000248-zueoyesj	91	5	can	can	MD
cord-000248-zueoyesj	91	6	be	be	VB
cord-000248-zueoyesj	91	7	defined	define	VBN
cord-000248-zueoyesj	91	8	which	which	WDT
cord-000248-zueoyesj	91	9	aim	aim	VBP
cord-000248-zueoyesj	91	10	to	to	TO
cord-000248-zueoyesj	91	11	clarify	clarify	VB
cord-000248-zueoyesj	91	12	our	-PRON-	PRP$
cord-000248-zueoyesj	91	13	argument	argument	NN
cord-000248-zueoyesj	91	14	.	.	.
cord-000248-zueoyesj	92	1	We	-PRON-	PRP
cord-000248-zueoyesj	92	2	will	will	MD
cord-000248-zueoyesj	92	3	first	first	RB
cord-000248-zueoyesj	92	4	discuss	discuss	VB
cord-000248-zueoyesj	92	5	the	the	DT
cord-000248-zueoyesj	92	6	results	result	NNS
cord-000248-zueoyesj	92	7	of	of	IN
cord-000248-zueoyesj	92	8	computing	compute	VBG
cord-000248-zueoyesj	92	9	the	the	DT
cord-000248-zueoyesj	92	10	MPR	MPR	NNP
cord-000248-zueoyesj	92	11	-	-	HYPH
cord-000248-zueoyesj	92	12	Statistical	Statistical	NNP
cord-000248-zueoyesj	92	13	Complexity	Complexity	NNP
cord-000248-zueoyesj	92	14	measure	measure	NN
cord-000248-zueoyesj	92	15	(	(	-LRB-
cord-000248-zueoyesj	92	16	in	in	IN
cord-000248-zueoyesj	92	17	the	the	DT
cord-000248-zueoyesj	92	18	previous	previous	JJ
cord-000248-zueoyesj	92	19	figure	figure	NN
cord-000248-zueoyesj	92	20	the	the	DT
cord-000248-zueoyesj	92	21	y	y	NN
cord-000248-zueoyesj	92	22	-	-	HYPH
cord-000248-zueoyesj	92	23	coordinates	coordinate	NNS
cord-000248-zueoyesj	92	24	correspond	correspond	VBP
cord-000248-zueoyesj	92	25	to	to	IN
cord-000248-zueoyesj	92	26	the	the	DT
cord-000248-zueoyesj	92	27	MPR	MPR	NNP
cord-000248-zueoyesj	92	28	-	-	HYPH
cord-000248-zueoyesj	92	29	Statistical	Statistical	NNP
cord-000248-zueoyesj	92	30	Complexity	Complexity	NNP
cord-000248-zueoyesj	92	31	values	value	NNS
cord-000248-zueoyesj	92	32	of	of	IN
cord-000248-zueoyesj	92	33	each	each	DT
cord-000248-zueoyesj	92	34	sample	sample	NN
cord-000248-zueoyesj	92	35	)	)	-RRB-
cord-000248-zueoyesj	92	36	.	.	.
cord-000248-zueoyesj	93	1	The	the	DT
cord-000248-zueoyesj	93	2	MPR	MPR	NNP
cord-000248-zueoyesj	93	3	-	-	HYPH
cord-000248-zueoyesj	93	4	Statistical	Statistical	NNP
cord-000248-zueoyesj	93	5	Complexity	Complexity	NNP
cord-000248-zueoyesj	93	6	is	be	VBZ
cord-000248-zueoyesj	93	7	proportional	proportional	JJ
cord-000248-zueoyesj	93	8	to	to	IN
cord-000248-zueoyesj	93	9	both	both	PDT
cord-000248-zueoyesj	93	10	the	the	DT
cord-000248-zueoyesj	93	11	Normalized	Normalized	NNP
cord-000248-zueoyesj	93	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	93	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	93	14	associated	associate	VBD
cord-000248-zueoyesj	93	15	to	to	IN
cord-000248-zueoyesj	93	16	the	the	DT
cord-000248-zueoyesj	93	17	transcription	transcription	NN
cord-000248-zueoyesj	93	18	profile	profile	NN
cord-000248-zueoyesj	93	19	and	and	CC
cord-000248-zueoyesj	93	20	the	the	DT
cord-000248-zueoyesj	93	21	Jensen	Jensen	NNP
cord-000248-zueoyesj	93	22	-	-	HYPH
cord-000248-zueoyesj	93	23	Shannon	Shannon	NNP
cord-000248-zueoyesj	93	24	's	's	POS
cord-000248-zueoyesj	93	25	divergence	divergence	NN
cord-000248-zueoyesj	93	26	between	between	IN
cord-000248-zueoyesj	93	27	that	that	DT
cord-000248-zueoyesj	93	28	probability	probability	NN
cord-000248-zueoyesj	93	29	density	density	NN
cord-000248-zueoyesj	93	30	function	function	NN
cord-000248-zueoyesj	93	31	and	and	CC
cord-000248-zueoyesj	93	32	the	the	DT
cord-000248-zueoyesj	93	33	uniform	uniform	JJ
cord-000248-zueoyesj	93	34	probability	probability	NN
cord-000248-zueoyesj	93	35	distribution	distribution	NN
cord-000248-zueoyesj	93	36	.	.	.
cord-000248-zueoyesj	94	1	Again	again	RB
cord-000248-zueoyesj	94	2	,	,	,
cord-000248-zueoyesj	94	3	we	-PRON-	PRP
cord-000248-zueoyesj	94	4	refer	refer	VBP
cord-000248-zueoyesj	94	5	the	the	DT
cord-000248-zueoyesj	94	6	reader	reader	NN
cord-000248-zueoyesj	94	7	to	to	IN
cord-000248-zueoyesj	94	8	the	the	DT
cord-000248-zueoyesj	94	9	'	'	``
cord-000248-zueoyesj	94	10	Materials	material	NNS
cord-000248-zueoyesj	94	11	and	and	CC
cord-000248-zueoyesj	94	12	Methods	Methods	NNPS
cord-000248-zueoyesj	94	13	'	'	POS
cord-000248-zueoyesj	94	14	section	section	NN
cord-000248-zueoyesj	94	15	for	for	IN
cord-000248-zueoyesj	94	16	an	an	DT
cord-000248-zueoyesj	94	17	explanation	explanation	NN
cord-000248-zueoyesj	94	18	of	of	IN
cord-000248-zueoyesj	94	19	how	how	WRB
cord-000248-zueoyesj	94	20	these	these	DT
cord-000248-zueoyesj	94	21	magnitudes	magnitude	NNS
cord-000248-zueoyesj	94	22	are	be	VBP
cord-000248-zueoyesj	94	23	computed	compute	VBN
cord-000248-zueoyesj	94	24	.	.	.
cord-000248-zueoyesj	95	1	Although	although	IN
cord-000248-zueoyesj	95	2	the	the	DT
cord-000248-zueoyesj	95	3	results	result	NNS
cord-000248-zueoyesj	95	4	of	of	IN
cord-000248-zueoyesj	95	5	using	use	VBG
cord-000248-zueoyesj	95	6	the	the	DT
cord-000248-zueoyesj	95	7	MPR	MPR	NNP
cord-000248-zueoyesj	95	8	-	-	HYPH
cord-000248-zueoyesj	95	9	Statistical	Statistical	NNP
cord-000248-zueoyesj	95	10	Complexity	Complexity	NNP
cord-000248-zueoyesj	95	11	might	may	MD
cord-000248-zueoyesj	95	12	not	not	RB
cord-000248-zueoyesj	95	13	seem	seem	VB
cord-000248-zueoyesj	95	14	particularly	particularly	RB
cord-000248-zueoyesj	95	15	impressive	impressive	JJ
cord-000248-zueoyesj	95	16	,	,	,
cord-000248-zueoyesj	95	17	there	there	EX
cord-000248-zueoyesj	95	18	are	be	VBP
cord-000248-zueoyesj	95	19	a	a	DT
cord-000248-zueoyesj	95	20	few	few	JJ
cord-000248-zueoyesj	95	21	reasons	reason	NNS
cord-000248-zueoyesj	95	22	why	why	WRB
cord-000248-zueoyesj	95	23	we	-PRON-	PRP
cord-000248-zueoyesj	95	24	introduce	introduce	VBP
cord-000248-zueoyesj	95	25	them	-PRON-	PRP
cord-000248-zueoyesj	95	26	at	at	IN
cord-000248-zueoyesj	95	27	this	this	DT
cord-000248-zueoyesj	95	28	stage	stage	NN
cord-000248-zueoyesj	95	29	.	.	.
cord-000248-zueoyesj	96	1	We	-PRON-	PRP
cord-000248-zueoyesj	96	2	want	want	VBP
cord-000248-zueoyesj	96	3	to	to	TO
cord-000248-zueoyesj	96	4	illustrate	illustrate	VB
cord-000248-zueoyesj	96	5	a	a	DT
cord-000248-zueoyesj	96	6	fact	fact	NN
cord-000248-zueoyesj	96	7	that	that	WDT
cord-000248-zueoyesj	96	8	can	can	MD
cord-000248-zueoyesj	96	9	already	already	RB
cord-000248-zueoyesj	96	10	be	be	VB
cord-000248-zueoyesj	96	11	observed	observe	VBN
cord-000248-zueoyesj	96	12	when	when	WRB
cord-000248-zueoyesj	96	13	we	-PRON-	PRP
cord-000248-zueoyesj	96	14	employ	employ	VBP
cord-000248-zueoyesj	96	15	this	this	DT
cord-000248-zueoyesj	96	16	measure	measure	NN
cord-000248-zueoyesj	96	17	on	on	IN
cord-000248-zueoyesj	96	18	this	this	DT
cord-000248-zueoyesj	96	19	dataset	dataset	NN
cord-000248-zueoyesj	96	20	.	.	.
cord-000248-zueoyesj	97	1	In	in	IN
cord-000248-zueoyesj	97	2	this	this	DT
cord-000248-zueoyesj	97	3	dataset	dataset	NN
cord-000248-zueoyesj	97	4	,	,	,
cord-000248-zueoyesj	97	5	for	for	IN
cord-000248-zueoyesj	97	6	a	a	DT
cord-000248-zueoyesj	97	7	given	give	VBN
cord-000248-zueoyesj	97	8	entropy	entropy	NN
cord-000248-zueoyesj	97	9	value	value	NN
cord-000248-zueoyesj	97	10	interval	interval	NN
cord-000248-zueoyesj	97	11	,	,	,
cord-000248-zueoyesj	97	12	normal	normal	JJ
cord-000248-zueoyesj	97	13	tissue	tissue	NN
cord-000248-zueoyesj	97	14	samples	sample	NNS
cord-000248-zueoyesj	97	15	tend	tend	VBP
cord-000248-zueoyesj	97	16	to	to	TO
cord-000248-zueoyesj	97	17	have	have	VB
cord-000248-zueoyesj	97	18	relatively	relatively	RB
cord-000248-zueoyesj	97	19	lower	low	JJR
cord-000248-zueoyesj	97	20	MPR	MPR	NNP
cord-000248-zueoyesj	97	21	-	-	HYPH
cord-000248-zueoyesj	97	22	Statistical	Statistical	NNP
cord-000248-zueoyesj	97	23	Complexity	Complexity	NNP
cord-000248-zueoyesj	97	24	values	value	NNS
cord-000248-zueoyesj	97	25	than	than	IN
cord-000248-zueoyesj	97	26	tumor	tumor	NN
cord-000248-zueoyesj	97	27	and	and	CC
cord-000248-zueoyesj	97	28	lymph	lymph	NN
cord-000248-zueoyesj	97	29	node	node	NN
cord-000248-zueoyesj	97	30	metastasis	metastasis	NN
cord-000248-zueoyesj	97	31	.	.	.
cord-000248-zueoyesj	98	1	This	this	DT
cord-000248-zueoyesj	98	2	means	mean	VBZ
cord-000248-zueoyesj	98	3	that	that	IN
cord-000248-zueoyesj	98	4	both	both	DT
cord-000248-zueoyesj	98	5	prostate	prostate	NN
cord-000248-zueoyesj	98	6	cancer	cancer	NN
cord-000248-zueoyesj	98	7	and	and	CC
cord-000248-zueoyesj	98	8	metastases	metastasis	NNS
cord-000248-zueoyesj	98	9	samples	sample	NNS
cord-000248-zueoyesj	98	10	diverge	diverge	VBP
cord-000248-zueoyesj	98	11	from	from	IN
cord-000248-zueoyesj	98	12	a	a	DT
cord-000248-zueoyesj	98	13	'	'	''
cord-000248-zueoyesj	98	14	'	'	``
cord-000248-zueoyesj	98	15	more	more	JJR
cord-000248-zueoyesj	98	16	uniform	uniform	NN
cord-000248-zueoyesj	98	17	'	'	''
cord-000248-zueoyesj	98	18	'	'	''
cord-000248-zueoyesj	98	19	distribution	distribution	NN
cord-000248-zueoyesj	98	20	indicating	indicate	VBG
cord-000248-zueoyesj	98	21	that	that	IN
cord-000248-zueoyesj	98	22	the	the	DT
cord-000248-zueoyesj	98	23	distribution	distribution	NN
cord-000248-zueoyesj	98	24	'	'	''
cord-000248-zueoyesj	98	25	'	'	``
cord-000248-zueoyesj	98	26	peaks	peak	NNS
cord-000248-zueoyesj	98	27	'	'	''
cord-000248-zueoyesj	98	28	'	'	''
cord-000248-zueoyesj	98	29	in	in	IN
cord-000248-zueoyesj	98	30	fewer	few	JJR
cord-000248-zueoyesj	98	31	active	active	JJ
cord-000248-zueoyesj	98	32	genes	gene	NNS
cord-000248-zueoyesj	98	33	.	.	.
cord-000248-zueoyesj	99	1	It	-PRON-	PRP
cord-000248-zueoyesj	99	2	also	also	RB
cord-000248-zueoyesj	99	3	means	mean	VBZ
cord-000248-zueoyesj	99	4	that	that	IN
cord-000248-zueoyesj	99	5	,	,	,
cord-000248-zueoyesj	99	6	in	in	IN
cord-000248-zueoyesj	99	7	terms	term	NNS
cord-000248-zueoyesj	99	8	of	of	IN
cord-000248-zueoyesj	99	9	Jensen	Jensen	NNP
cord-000248-zueoyesj	99	10	-	-	HYPH
cord-000248-zueoyesj	99	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	99	12	's	's	POS
cord-000248-zueoyesj	99	13	divergence	divergence	NN
cord-000248-zueoyesj	99	14	,	,	,
cord-000248-zueoyesj	99	15	the	the	DT
cord-000248-zueoyesj	99	16	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	99	17	profile	profile	NN
cord-000248-zueoyesj	99	18	of	of	IN
cord-000248-zueoyesj	99	19	a	a	DT
cord-000248-zueoyesj	99	20	normal	normal	JJ
cord-000248-zueoyesj	99	21	prostate	prostate	NN
cord-000248-zueoyesj	99	22	cell	cell	NN
cord-000248-zueoyesj	99	23	sample	sample	NN
cord-000248-zueoyesj	99	24	is	be	VBZ
cord-000248-zueoyesj	99	25	'	'	``
cord-000248-zueoyesj	99	26	'	'	``
cord-000248-zueoyesj	99	27	closer	close	RBR
cord-000248-zueoyesj	99	28	'	'	''
cord-000248-zueoyesj	99	29	'	'	''
cord-000248-zueoyesj	99	30	to	to	IN
cord-000248-zueoyesj	99	31	a	a	DT
cord-000248-zueoyesj	99	32	uniform	uniform	JJ
cord-000248-zueoyesj	99	33	distribution	distribution	NN
cord-000248-zueoyesj	99	34	than	than	IN
cord-000248-zueoyesj	99	35	to	to	IN
cord-000248-zueoyesj	99	36	the	the	DT
cord-000248-zueoyesj	99	37	one	one	NN
cord-000248-zueoyesj	99	38	that	that	WDT
cord-000248-zueoyesj	99	39	is	be	VBZ
cord-000248-zueoyesj	99	40	observed	observe	VBN
cord-000248-zueoyesj	99	41	in	in	IN
cord-000248-zueoyesj	99	42	a	a	DT
cord-000248-zueoyesj	99	43	prostate	prostate	NN
cord-000248-zueoyesj	99	44	cancer	cancer	NN
cord-000248-zueoyesj	99	45	cell	cell	NN
cord-000248-zueoyesj	99	46	sample	sample	NN
cord-000248-zueoyesj	99	47	.	.	.
cord-000248-zueoyesj	100	1	The	the	DT
cord-000248-zueoyesj	100	2	reader	reader	NN
cord-000248-zueoyesj	100	3	will	will	MD
cord-000248-zueoyesj	100	4	readily	readily	RB
cord-000248-zueoyesj	100	5	argue	argue	VB
cord-000248-zueoyesj	100	6	,	,	,
cord-000248-zueoyesj	100	7	and	and	CC
cord-000248-zueoyesj	100	8	with	with	IN
cord-000248-zueoyesj	100	9	reason	reason	NN
cord-000248-zueoyesj	100	10	,	,	,
cord-000248-zueoyesj	100	11	that	that	IN
cord-000248-zueoyesj	100	12	the	the	DT
cord-000248-zueoyesj	100	13	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	100	14	profile	profile	NN
cord-000248-zueoyesj	100	15	of	of	IN
cord-000248-zueoyesj	100	16	a	a	DT
cord-000248-zueoyesj	100	17	normal	normal	JJ
cord-000248-zueoyesj	100	18	cell	cell	NN
cord-000248-zueoyesj	100	19	is	be	VBZ
cord-000248-zueoyesj	100	20	tissue	tissue	NN
cord-000248-zueoyesj	100	21	-	-	HYPH
cord-000248-zueoyesj	100	22	specific	specific	JJ
cord-000248-zueoyesj	100	23	and	and	CC
cord-000248-zueoyesj	100	24	that	that	IN
cord-000248-zueoyesj	100	25	it	-PRON-	PRP
cord-000248-zueoyesj	100	26	hardly	hardly	RB
cord-000248-zueoyesj	100	27	resembles	resemble	VBZ
cord-000248-zueoyesj	100	28	that	that	DT
cord-000248-zueoyesj	100	29	of	of	IN
cord-000248-zueoyesj	100	30	a	a	DT
cord-000248-zueoyesj	100	31	uniform	uniform	JJ
cord-000248-zueoyesj	100	32	distribution	distribution	NN
cord-000248-zueoyesj	100	33	of	of	IN
cord-000248-zueoyesj	100	34	expression	expression	NN
cord-000248-zueoyesj	100	35	values	value	NNS
cord-000248-zueoyesj	100	36	.	.	.
cord-000248-zueoyesj	101	1	That	that	DT
cord-000248-zueoyesj	101	2	is	be	VBZ
cord-000248-zueoyesj	101	3	correct	correct	JJ
cord-000248-zueoyesj	101	4	and	and	CC
cord-000248-zueoyesj	101	5	this	this	DT
cord-000248-zueoyesj	101	6	observation	observation	NN
cord-000248-zueoyesj	101	7	motivates	motivate	VBZ
cord-000248-zueoyesj	101	8	the	the	DT
cord-000248-zueoyesj	101	9	introduction	introduction	NN
cord-000248-zueoyesj	101	10	of	of	IN
cord-000248-zueoyesj	101	11	two	two	CD
cord-000248-zueoyesj	101	12	new	new	JJ
cord-000248-zueoyesj	101	13	statistical	statistical	JJ
cord-000248-zueoyesj	101	14	complexity	complexity	NN
cord-000248-zueoyesj	101	15	measures	measure	NNS
cord-000248-zueoyesj	101	16	.	.	.
cord-000248-zueoyesj	102	1	We	-PRON-	PRP
cord-000248-zueoyesj	102	2	generically	generically	RB
cord-000248-zueoyesj	102	3	call	call	VBP
cord-000248-zueoyesj	102	4	these	these	DT
cord-000248-zueoyesj	102	5	two	two	CD
cord-000248-zueoyesj	102	6	variants	variant	NNS
cord-000248-zueoyesj	102	7	as	as	IN
cord-000248-zueoyesj	102	8	'	'	``
cord-000248-zueoyesj	102	9	M	M	NNP
cord-000248-zueoyesj	102	10	-	-	HYPH
cord-000248-zueoyesj	102	11	complexities	complexity	NNS
cord-000248-zueoyesj	102	12	'	'	''
cord-000248-zueoyesj	102	13	(	(	-LRB-
cord-000248-zueoyesj	102	14	with	with	IN
cord-000248-zueoyesj	102	15	'	'	``
cord-000248-zueoyesj	102	16	M	M	NNP
cord-000248-zueoyesj	102	17	'	'	''
cord-000248-zueoyesj	102	18	standing	standing	NN
cord-000248-zueoyesj	102	19	for	for	IN
cord-000248-zueoyesj	102	20	'	'	''
cord-000248-zueoyesj	102	21	'	'	``
cord-000248-zueoyesj	102	22	modified	modify	VBN
cord-000248-zueoyesj	102	23	'	'	''
cord-000248-zueoyesj	102	24	'	'	''
cord-000248-zueoyesj	102	25	)	)	-RRB-
cord-000248-zueoyesj	102	26	.	.	.
cord-000248-zueoyesj	103	1	They	-PRON-	PRP
cord-000248-zueoyesj	103	2	have	have	VBP
cord-000248-zueoyesj	103	3	the	the	DT
cord-000248-zueoyesj	103	4	same	same	JJ
cord-000248-zueoyesj	103	5	functional	functional	JJ
cord-000248-zueoyesj	103	6	form	form	NN
cord-000248-zueoyesj	103	7	as	as	IN
cord-000248-zueoyesj	103	8	the	the	DT
cord-000248-zueoyesj	103	9	MPR	MPR	NNP
cord-000248-zueoyesj	103	10	-	-	HYPH
cord-000248-zueoyesj	103	11	Statistical	Statistical	NNP
cord-000248-zueoyesj	103	12	Complexity	Complexity	NNP
cord-000248-zueoyesj	103	13	,	,	,
cord-000248-zueoyesj	103	14	but	but	CC
cord-000248-zueoyesj	103	15	instead	instead	RB
cord-000248-zueoyesj	103	16	of	of	IN
cord-000248-zueoyesj	103	17	computing	compute	VBG
cord-000248-zueoyesj	103	18	the	the	DT
cord-000248-zueoyesj	103	19	Jensen	Jensen	NNP
cord-000248-zueoyesj	103	20	-	-	HYPH
cord-000248-zueoyesj	103	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	103	22	's	's	POS
cord-000248-zueoyesj	103	23	divergence	divergence	NN
cord-000248-zueoyesj	103	24	from	from	IN
cord-000248-zueoyesj	103	25	a	a	DT
cord-000248-zueoyesj	103	26	uniform	uniform	JJ
cord-000248-zueoyesj	103	27	probability	probability	NN
cord-000248-zueoyesj	103	28	distribution	distribution	NN
cord-000248-zueoyesj	103	29	we	-PRON-	PRP
cord-000248-zueoyesj	103	30	compute	compute	VBP
cord-000248-zueoyesj	103	31	it	-PRON-	PRP
cord-000248-zueoyesj	103	32	against	against	IN
cord-000248-zueoyesj	103	33	an	an	DT
cord-000248-zueoyesj	103	34	ad	ad	FW
cord-000248-zueoyesj	103	35	hoc	hoc	FW
cord-000248-zueoyesj	103	36	probability	probability	NN
cord-000248-zueoyesj	103	37	distribution	distribution	NN
cord-000248-zueoyesj	103	38	functions	function	NNS
cord-000248-zueoyesj	103	39	derived	derive	VBN
cord-000248-zueoyesj	103	40	from	from	IN
cord-000248-zueoyesj	103	41	the	the	DT
cord-000248-zueoyesj	103	42	data	datum	NNS
cord-000248-zueoyesj	103	43	.	.	.
cord-000248-zueoyesj	104	1	In	in	IN
cord-000248-zueoyesj	104	2	this	this	DT
cord-000248-zueoyesj	104	3	sense	sense	NN
cord-000248-zueoyesj	104	4	,	,	,
cord-000248-zueoyesj	104	5	these	these	DT
cord-000248-zueoyesj	104	6	measures	measure	NNS
cord-000248-zueoyesj	104	7	are	be	VBP
cord-000248-zueoyesj	104	8	more	more	RBR
cord-000248-zueoyesj	104	9	supervised	supervise	VBN
cord-000248-zueoyesj	104	10	then	then	RB
cord-000248-zueoyesj	104	11	the	the	DT
cord-000248-zueoyesj	104	12	MPR	MPR	NNP
cord-000248-zueoyesj	104	13	-	-	HYPH
cord-000248-zueoyesj	104	14	Statistical	Statistical	NNP
cord-000248-zueoyesj	104	15	Complexity	Complexity	NNP
cord-000248-zueoyesj	104	16	is	be	VBZ
cord-000248-zueoyesj	104	17	.	.	.
cord-000248-zueoyesj	105	1	Another	another	DT
cord-000248-zueoyesj	105	2	perspective	perspective	NN
cord-000248-zueoyesj	105	3	is	be	VBZ
cord-000248-zueoyesj	105	4	that	that	IN
cord-000248-zueoyesj	105	5	the	the	DT
cord-000248-zueoyesj	105	6	MPR	MPR	NNP
cord-000248-zueoyesj	105	7	-	-	HYPH
cord-000248-zueoyesj	105	8	Statistical	Statistical	NNP
cord-000248-zueoyesj	105	9	Complexity	Complexity	NNP
cord-000248-zueoyesj	105	10	is	be	VBZ
cord-000248-zueoyesj	105	11	a	a	DT
cord-000248-zueoyesj	105	12	special	special	JJ
cord-000248-zueoyesj	105	13	case	case	NN
cord-000248-zueoyesj	105	14	of	of	IN
cord-000248-zueoyesj	105	15	this	this	DT
cord-000248-zueoyesj	105	16	measure	measure	NN
cord-000248-zueoyesj	105	17	in	in	IN
cord-000248-zueoyesj	105	18	which	which	WDT
cord-000248-zueoyesj	105	19	the	the	DT
cord-000248-zueoyesj	105	20	ad	ad	FW
cord-000248-zueoyesj	105	21	hoc	hoc	FW
cord-000248-zueoyesj	105	22	probability	probability	NN
cord-000248-zueoyesj	105	23	distribution	distribution	NN
cord-000248-zueoyesj	105	24	function	function	NN
cord-000248-zueoyesj	105	25	of	of	IN
cord-000248-zueoyesj	105	26	reference	reference	NN
cord-000248-zueoyesj	105	27	is	be	VBZ
cord-000248-zueoyesj	105	28	the	the	DT
cord-000248-zueoyesj	105	29	equiprobability	equiprobability	NN
cord-000248-zueoyesj	105	30	distribution	distribution	NN
cord-000248-zueoyesj	105	31	.	.	.
cord-000248-zueoyesj	106	1	The	the	DT
cord-000248-zueoyesj	106	2	relevance	relevance	NN
cord-000248-zueoyesj	106	3	of	of	IN
cord-000248-zueoyesj	106	4	this	this	DT
cord-000248-zueoyesj	106	5	measure	measure	NN
cord-000248-zueoyesj	106	6	derives	derive	VBZ
cord-000248-zueoyesj	106	7	from	from	IN
cord-000248-zueoyesj	106	8	being	be	VBG
cord-000248-zueoyesj	106	9	a	a	DT
cord-000248-zueoyesj	106	10	general	general	JJ
cord-000248-zueoyesj	106	11	definition	definition	NN
cord-000248-zueoyesj	106	12	that	that	WDT
cord-000248-zueoyesj	106	13	allows	allow	VBZ
cord-000248-zueoyesj	106	14	[	[	-LRB-
cord-000248-zueoyesj	106	15	44	44	CD
cord-000248-zueoyesj	106	16	]	]	-RRB-
cord-000248-zueoyesj	106	17	.	.	.
cord-000248-zueoyesj	107	1	Metastatic	metastatic	JJ
cord-000248-zueoyesj	107	2	samples	sample	NNS
cord-000248-zueoyesj	107	3	have	have	VBP
cord-000248-zueoyesj	107	4	typically	typically	RB
cord-000248-zueoyesj	107	5	lower	low	JJR
cord-000248-zueoyesj	107	6	values	value	NNS
cord-000248-zueoyesj	107	7	of	of	IN
cord-000248-zueoyesj	107	8	Normalized	Normalized	NNP
cord-000248-zueoyesj	107	9	Shannon	Shannon	NNP
cord-000248-zueoyesj	107	10	Entropy	Entropy	NNP
cord-000248-zueoyesj	107	11	than	than	IN
cord-000248-zueoyesj	107	12	normal	normal	JJ
cord-000248-zueoyesj	107	13	samples	sample	NNS
cord-000248-zueoyesj	107	14	and	and	CC
cord-000248-zueoyesj	107	15	prostate	prostate	NN
cord-000248-zueoyesj	107	16	cancer	cancer	NN
cord-000248-zueoyesj	107	17	primary	primary	JJ
cord-000248-zueoyesj	107	18	tumors	tumor	NNS
cord-000248-zueoyesj	107	19	.	.	.
cord-000248-zueoyesj	108	1	The	the	DT
cord-000248-zueoyesj	108	2	reduction	reduction	NN
cord-000248-zueoyesj	108	3	in	in	IN
cord-000248-zueoyesj	108	4	Normalized	Normalized	NNP
cord-000248-zueoyesj	108	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	108	6	Entropy	Entropy	NNP
cord-000248-zueoyesj	108	7	indicates	indicate	VBZ
cord-000248-zueoyesj	108	8	that	that	IN
cord-000248-zueoyesj	108	9	there	there	EX
cord-000248-zueoyesj	108	10	exists	exist	VBZ
cord-000248-zueoyesj	108	11	a	a	DT
cord-000248-zueoyesj	108	12	significant	significant	JJ
cord-000248-zueoyesj	108	13	reduction	reduction	NN
cord-000248-zueoyesj	108	14	on	on	IN
cord-000248-zueoyesj	108	15	the	the	DT
cord-000248-zueoyesj	108	16	expression	expression	NN
cord-000248-zueoyesj	108	17	of	of	IN
cord-000248-zueoyesj	108	18	a	a	DT
cord-000248-zueoyesj	108	19	large	large	JJ
cord-000248-zueoyesj	108	20	number	number	NN
cord-000248-zueoyesj	108	21	of	of	IN
cord-000248-zueoyesj	108	22	genes	gene	NNS
cord-000248-zueoyesj	108	23	,	,	,
cord-000248-zueoyesj	108	24	or	or	CC
cord-000248-zueoyesj	108	25	that	that	IN
cord-000248-zueoyesj	108	26	the	the	DT
cord-000248-zueoyesj	108	27	gene	gene	NN
cord-000248-zueoyesj	108	28	profile	profile	NN
cord-000248-zueoyesj	108	29	of	of	IN
cord-000248-zueoyesj	108	30	metastatic	metastatic	JJ
cord-000248-zueoyesj	108	31	samples	sample	NNS
cord-000248-zueoyesj	108	32	has	have	VBZ
cord-000248-zueoyesj	108	33	a	a	DT
cord-000248-zueoyesj	108	34	more	more	RBR
cord-000248-zueoyesj	108	35	'	'	''
cord-000248-zueoyesj	108	36	'	'	''
cord-000248-zueoyesj	108	37	peaked	peak	VBD
cord-000248-zueoyesj	108	38	'	'	''
cord-000248-zueoyesj	108	39	'	'	''
cord-000248-zueoyesj	108	40	distribution	distribution	NN
cord-000248-zueoyesj	108	41	(	(	-LRB-
cord-000248-zueoyesj	108	42	due	due	IN
cord-000248-zueoyesj	108	43	to	to	IN
cord-000248-zueoyesj	108	44	the	the	DT
cord-000248-zueoyesj	108	45	upregulation	upregulation	NN
cord-000248-zueoyesj	108	46	of	of	IN
cord-000248-zueoyesj	108	47	a	a	DT
cord-000248-zueoyesj	108	48	selected	select	VBN
cord-000248-zueoyesj	108	49	subset	subset	NN
cord-000248-zueoyesj	108	50	of	of	IN
cord-000248-zueoyesj	108	51	genes	gene	NNS
cord-000248-zueoyesj	108	52	)	)	-RRB-
cord-000248-zueoyesj	108	53	.	.	.
cord-000248-zueoyesj	109	1	Both	both	DT
cord-000248-zueoyesj	109	2	possibilities	possibility	NNS
cord-000248-zueoyesj	109	3	just	just	RB
cord-000248-zueoyesj	109	4	cited	cite	VBN
cord-000248-zueoyesj	109	5	are	be	VBP
cord-000248-zueoyesj	109	6	not	not	RB
cord-000248-zueoyesj	109	7	mutually	mutually	RB
cord-000248-zueoyesj	109	8	exclusive	exclusive	JJ
cord-000248-zueoyesj	109	9	.	.	.
cord-000248-zueoyesj	110	1	We	-PRON-	PRP
cord-000248-zueoyesj	110	2	also	also	RB
cord-000248-zueoyesj	110	3	note	note	VBP
cord-000248-zueoyesj	110	4	that	that	IN
cord-000248-zueoyesj	110	5	neither	neither	CC
cord-000248-zueoyesj	110	6	the	the	DT
cord-000248-zueoyesj	110	7	Normalized	Normalized	NNP
cord-000248-zueoyesj	110	8	Shannon	Shannon	NNP
cord-000248-zueoyesj	110	9	Entropy	Entropy	NNP
cord-000248-zueoyesj	110	10	,	,	,
cord-000248-zueoyesj	110	11	nor	nor	CC
cord-000248-zueoyesj	110	12	the	the	DT
cord-000248-zueoyesj	110	13	MPR	MPR	NNP
cord-000248-zueoyesj	110	14	-	-	HYPH
cord-000248-zueoyesj	110	15	Statistical	Statistical	NNP
cord-000248-zueoyesj	110	16	Complexity	Complexity	NNP
cord-000248-zueoyesj	110	17	(	(	-LRB-
cord-000248-zueoyesj	110	18	as	as	IN
cord-000248-zueoyesj	110	19	a	a	DT
cord-000248-zueoyesj	110	20	single	single	JJ
cord-000248-zueoyesj	110	21	unsupervised	unsupervised	JJ
cord-000248-zueoyesj	110	22	quantifier	quantifier	NN
cord-000248-zueoyesj	110	23	)	)	-RRB-
cord-000248-zueoyesj	110	24	,	,	,
cord-000248-zueoyesj	110	25	can	can	MD
cord-000248-zueoyesj	110	26	help	help	VB
cord-000248-zueoyesj	110	27	differentiate	differentiate	VB
cord-000248-zueoyesj	110	28	between	between	IN
cord-000248-zueoyesj	110	29	tumor	tumor	NN
cord-000248-zueoyesj	110	30	and	and	CC
cord-000248-zueoyesj	110	31	normal	normal	JJ
cord-000248-zueoyesj	110	32	samples	sample	NNS
cord-000248-zueoyesj	110	33	,	,	,
cord-000248-zueoyesj	110	34	indicating	indicate	VBG
cord-000248-zueoyesj	110	35	that	that	IN
cord-000248-zueoyesj	110	36	other	other	JJ
cord-000248-zueoyesj	110	37	Information	information	NN
cord-000248-zueoyesj	110	38	Theory	Theory	NNP
cord-000248-zueoyesj	110	39	quantifiers	quantifier	NNS
cord-000248-zueoyesj	110	40	are	be	VBP
cord-000248-zueoyesj	110	41	required	require	VBN
cord-000248-zueoyesj	110	42	for	for	IN
cord-000248-zueoyesj	110	43	this	this	DT
cord-000248-zueoyesj	110	44	discrimination	discrimination	NN
cord-000248-zueoyesj	110	45	.	.	.
cord-000248-zueoyesj	111	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	112	1	/journal.pone.0012262.g001	/journal.pone.0012262.g001	:
cord-000248-zueoyesj	112	2	accommodating	accommodate	VBG
cord-000248-zueoyesj	112	3	several	several	JJ
cord-000248-zueoyesj	112	4	different	different	JJ
cord-000248-zueoyesj	112	5	reference	reference	NN
cord-000248-zueoyesj	112	6	states	state	NNS
cord-000248-zueoyesj	112	7	.	.	.
cord-000248-zueoyesj	113	1	We	-PRON-	PRP
cord-000248-zueoyesj	113	2	will	will	MD
cord-000248-zueoyesj	113	3	use	use	VB
cord-000248-zueoyesj	113	4	it	-PRON-	PRP
cord-000248-zueoyesj	113	5	to	to	TO
cord-000248-zueoyesj	113	6	measure	measure	VB
cord-000248-zueoyesj	113	7	divergences	divergence	NNS
cord-000248-zueoyesj	113	8	to	to	IN
cord-000248-zueoyesj	113	9	the	the	DT
cord-000248-zueoyesj	113	10	'	'	``
cord-000248-zueoyesj	113	11	'	'	``
cord-000248-zueoyesj	113	12	initial	initial	NN
cord-000248-zueoyesj	113	13	'	'	''
cord-000248-zueoyesj	113	14	'	'	''
cord-000248-zueoyesj	113	15	and	and	CC
cord-000248-zueoyesj	113	16	'	'	``
cord-000248-zueoyesj	113	17	'	'	``
cord-000248-zueoyesj	113	18	final	final	JJ
cord-000248-zueoyesj	113	19	'	'	''
cord-000248-zueoyesj	113	20	'	'	''
cord-000248-zueoyesj	113	21	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	113	22	states	state	NNS
cord-000248-zueoyesj	113	23	(	(	-LRB-
cord-000248-zueoyesj	113	24	two	two	CD
cord-000248-zueoyesj	113	25	states	state	NNS
cord-000248-zueoyesj	113	26	of	of	IN
cord-000248-zueoyesj	113	27	reference	reference	NN
cord-000248-zueoyesj	113	28	)	)	-RRB-
cord-000248-zueoyesj	113	29	.	.	.
cord-000248-zueoyesj	114	1	Taken	take	VBN
cord-000248-zueoyesj	114	2	as	as	IN
cord-000248-zueoyesj	114	3	computed	compute	VBN
cord-000248-zueoyesj	114	4	averages	average	NNS
cord-000248-zueoyesj	114	5	over	over	IN
cord-000248-zueoyesj	114	6	normal	normal	JJ
cord-000248-zueoyesj	114	7	samples	sample	NNS
cord-000248-zueoyesj	114	8	,	,	,
cord-000248-zueoyesj	114	9	and	and	CC
cord-000248-zueoyesj	114	10	respectively	respectively	RB
cord-000248-zueoyesj	114	11	metastatic	metastatic	JJ
cord-000248-zueoyesj	114	12	ones	one	NNS
cord-000248-zueoyesj	114	13	,	,	,
cord-000248-zueoyesj	114	14	these	these	DT
cord-000248-zueoyesj	114	15	measures	measure	NNS
cord-000248-zueoyesj	114	16	will	will	MD
cord-000248-zueoyesj	114	17	allow	allow	VB
cord-000248-zueoyesj	114	18	tracking	track	VBG
cord-000248-zueoyesj	114	19	the	the	DT
cord-000248-zueoyesj	114	20	processes	process	NNS
cord-000248-zueoyesj	114	21	of	of	IN
cord-000248-zueoyesj	114	22	differentiation	differentiation	NN
cord-000248-zueoyesj	114	23	of	of	IN
cord-000248-zueoyesj	114	24	a	a	DT
cord-000248-zueoyesj	114	25	cancer	cancer	NN
cord-000248-zueoyesj	114	26	cell	cell	NN
cord-000248-zueoyesj	114	27	from	from	IN
cord-000248-zueoyesj	114	28	a	a	DT
cord-000248-zueoyesj	114	29	particular	particular	JJ
cord-000248-zueoyesj	114	30	tissue	tissue	NN
cord-000248-zueoyesj	114	31	type	type	NN
cord-000248-zueoyesj	114	32	.	.	.
cord-000248-zueoyesj	115	1	For	for	IN
cord-000248-zueoyesj	115	2	example	example	NN
cord-000248-zueoyesj	115	3	,	,	,
cord-000248-zueoyesj	115	4	using	use	VBG
cord-000248-zueoyesj	115	5	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	115	6	et	et	FW
cord-000248-zueoyesj	115	7	al	al	NNP
cord-000248-zueoyesj	115	8	.	.	NNP
cord-000248-zueoyesj	115	9	's	's	POS
cord-000248-zueoyesj	115	10	dataset	dataset	NN
cord-000248-zueoyesj	115	11	,	,	,
cord-000248-zueoyesj	115	12	the	the	DT
cord-000248-zueoyesj	115	13	M	M	NNP
cord-000248-zueoyesj	115	14	-	-	HYPH
cord-000248-zueoyesj	115	15	Normal	normal	JJ
cord-000248-zueoyesj	115	16	statistical	statistical	JJ
cord-000248-zueoyesj	115	17	complexity	complexity	NN
cord-000248-zueoyesj	115	18	quantifier	quantifier	NN
cord-000248-zueoyesj	115	19	first	first	RB
cord-000248-zueoyesj	115	20	requires	require	VBZ
cord-000248-zueoyesj	115	21	the	the	DT
cord-000248-zueoyesj	115	22	computation	computation	NN
cord-000248-zueoyesj	115	23	of	of	IN
cord-000248-zueoyesj	115	24	the	the	DT
cord-000248-zueoyesj	115	25	probability	probability	NN
cord-000248-zueoyesj	115	26	distribution	distribution	NN
cord-000248-zueoyesj	115	27	function	function	NN
cord-000248-zueoyesj	115	28	of	of	IN
cord-000248-zueoyesj	115	29	the	the	DT
cord-000248-zueoyesj	115	30	average	average	JJ
cord-000248-zueoyesj	115	31	gene	gene	NN
cord-000248-zueoyesj	115	32	expression	expression	NN
cord-000248-zueoyesj	115	33	profile	profile	NN
cord-000248-zueoyesj	115	34	of	of	IN
cord-000248-zueoyesj	115	35	all	all	DT
cord-000248-zueoyesj	115	36	normal	normal	JJ
cord-000248-zueoyesj	115	37	prostate	prostate	NN
cord-000248-zueoyesj	115	38	samples	sample	NNS
cord-000248-zueoyesj	115	39	.	.	.
cord-000248-zueoyesj	116	1	Afterwards	afterwards	RB
cord-000248-zueoyesj	116	2	,	,	,
cord-000248-zueoyesj	116	3	the	the	DT
cord-000248-zueoyesj	116	4	Normalized	Normalized	NNP
cord-000248-zueoyesj	116	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	116	6	Entropy	Entropy	NNP
cord-000248-zueoyesj	116	7	and	and	CC
cord-000248-zueoyesj	116	8	the	the	DT
cord-000248-zueoyesj	116	9	Jensen	Jensen	NNP
cord-000248-zueoyesj	116	10	-	-	HYPH
cord-000248-zueoyesj	116	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	116	12	's	's	POS
cord-000248-zueoyesj	116	13	divergence	divergence	NN
cord-000248-zueoyesj	116	14	of	of	IN
cord-000248-zueoyesj	116	15	any	any	DT
cord-000248-zueoyesj	116	16	sample	sample	NN
cord-000248-zueoyesj	116	17	profile	profile	NN
cord-000248-zueoyesj	116	18	will	will	MD
cord-000248-zueoyesj	116	19	be	be	VB
cord-000248-zueoyesj	116	20	computed	compute	VBN
cord-000248-zueoyesj	116	21	using	use	VBG
cord-000248-zueoyesj	116	22	the	the	DT
cord-000248-zueoyesj	116	23	divergence	divergence	NN
cord-000248-zueoyesj	116	24	to	to	IN
cord-000248-zueoyesj	116	25	that	that	DT
cord-000248-zueoyesj	116	26	averaged	average	VBD
cord-000248-zueoyesj	116	27	normal	normal	JJ
cord-000248-zueoyesj	116	28	distribution	distribution	NN
cord-000248-zueoyesj	116	29	.	.	.
cord-000248-zueoyesj	117	1	Analogously	analogously	RB
cord-000248-zueoyesj	117	2	,	,	,
cord-000248-zueoyesj	117	3	we	-PRON-	PRP
cord-000248-zueoyesj	117	4	compute	compute	VBP
cord-000248-zueoyesj	117	5	the	the	DT
cord-000248-zueoyesj	117	6	M	M	NNP
cord-000248-zueoyesj	117	7	-	-	HYPH
cord-000248-zueoyesj	117	8	Metastases	Metastases	NNP
cord-000248-zueoyesj	117	9	statistical	statistical	JJ
cord-000248-zueoyesj	117	10	complexity	complexity	NN
cord-000248-zueoyesj	117	11	quantifier	quantifier	NN
cord-000248-zueoyesj	117	12	by	by	IN
cord-000248-zueoyesj	117	13	first	first	JJ
cord-000248-zueoyesj	117	14	calculating	calculate	VBG
cord-000248-zueoyesj	117	15	the	the	DT
cord-000248-zueoyesj	117	16	average	average	JJ
cord-000248-zueoyesj	117	17	profile	profile	NN
cord-000248-zueoyesj	117	18	of	of	IN
cord-000248-zueoyesj	117	19	the	the	DT
cord-000248-zueoyesj	117	20	metastases	metastasis	NNS
cord-000248-zueoyesj	117	21	samples	sample	NNS
cord-000248-zueoyesj	117	22	,	,	,
cord-000248-zueoyesj	117	23	and	and	CC
cord-000248-zueoyesj	117	24	then	then	RB
cord-000248-zueoyesj	117	25	generating	generate	VBG
cord-000248-zueoyesj	117	26	the	the	DT
cord-000248-zueoyesj	117	27	corresponding	corresponding	JJ
cord-000248-zueoyesj	117	28	probability	probability	NN
cord-000248-zueoyesj	117	29	distribution	distribution	NN
cord-000248-zueoyesj	117	30	function	function	NN
cord-000248-zueoyesj	117	31	,	,	,
cord-000248-zueoyesj	117	32	finally	finally	RB
cord-000248-zueoyesj	117	33	computing	compute	VBG
cord-000248-zueoyesj	117	34	the	the	DT
cord-000248-zueoyesj	117	35	Jensen	Jensen	NNP
cord-000248-zueoyesj	117	36	-	-	HYPH
cord-000248-zueoyesj	117	37	Shannon	Shannon	NNP
cord-000248-zueoyesj	117	38	's	's	POS
cord-000248-zueoyesj	117	39	divergence	divergence	NN
cord-000248-zueoyesj	117	40	with	with	IN
cord-000248-zueoyesj	117	41	that	that	DT
cord-000248-zueoyesj	117	42	profile	profile	NN
cord-000248-zueoyesj	117	43	.	.	.
cord-000248-zueoyesj	118	1	We	-PRON-	PRP
cord-000248-zueoyesj	118	2	refer	refer	VBP
cord-000248-zueoyesj	118	3	to	to	IN
cord-000248-zueoyesj	118	4	the	the	DT
cord-000248-zueoyesj	118	5	'	'	``
cord-000248-zueoyesj	118	6	Materials	material	NNS
cord-000248-zueoyesj	118	7	and	and	CC
cord-000248-zueoyesj	118	8	Methods	Methods	NNPS
cord-000248-zueoyesj	118	9	'	'	POS
cord-000248-zueoyesj	118	10	section	section	NN
cord-000248-zueoyesj	118	11	for	for	IN
cord-000248-zueoyesj	118	12	details	detail	NNS
cord-000248-zueoyesj	118	13	of	of	IN
cord-000248-zueoyesj	118	14	the	the	DT
cord-000248-zueoyesj	118	15	calculations	calculation	NNS
cord-000248-zueoyesj	118	16	.	.	.
cord-000248-zueoyesj	119	1	The	the	DT
cord-000248-zueoyesj	119	2	results	result	NNS
cord-000248-zueoyesj	119	3	can	can	MD
cord-000248-zueoyesj	119	4	be	be	VB
cord-000248-zueoyesj	119	5	observed	observe	VBN
cord-000248-zueoyesj	119	6	in	in	IN
cord-000248-zueoyesj	119	7	Figure	figure	NN
cord-000248-zueoyesj	119	8	2	2	CD
cord-000248-zueoyesj	119	9	.	.	.
cord-000248-zueoyesj	120	1	On	on	IN
cord-000248-zueoyesj	120	2	the	the	DT
cord-000248-zueoyesj	120	3	x	x	NN
cord-000248-zueoyesj	120	4	-	-	HYPH
cord-000248-zueoyesj	120	5	axis	axis	NN
cord-000248-zueoyesj	120	6	,	,	,
cord-000248-zueoyesj	120	7	the	the	DT
cord-000248-zueoyesj	120	8	lymph	lymph	NN
cord-000248-zueoyesj	120	9	node	node	NN
cord-000248-zueoyesj	120	10	metastases	metastasis	NNS
cord-000248-zueoyesj	120	11	have	have	VBP
cord-000248-zueoyesj	120	12	the	the	DT
cord-000248-zueoyesj	120	13	largest	large	JJS
cord-000248-zueoyesj	120	14	values	value	NNS
cord-000248-zueoyesj	120	15	of	of	IN
cord-000248-zueoyesj	120	16	M	M	NNP
cord-000248-zueoyesj	120	17	-	-	HYPH
cord-000248-zueoyesj	120	18	Normal	Normal	NNP
cord-000248-zueoyesj	120	19	indicating	indicate	VBG
cord-000248-zueoyesj	120	20	a	a	DT
cord-000248-zueoyesj	120	21	divergence	divergence	NN
cord-000248-zueoyesj	120	22	from	from	IN
cord-000248-zueoyesj	120	23	the	the	DT
cord-000248-zueoyesj	120	24	normal	normal	JJ
cord-000248-zueoyesj	120	25	profile	profile	NN
cord-000248-zueoyesj	120	26	.	.	.
cord-000248-zueoyesj	121	1	In	in	IN
cord-000248-zueoyesj	121	2	addition	addition	NN
cord-000248-zueoyesj	121	3	,	,	,
cord-000248-zueoyesj	121	4	the	the	DT
cord-000248-zueoyesj	121	5	M	M	NNP
cord-000248-zueoyesj	121	6	-	-	HYPH
cord-000248-zueoyesj	121	7	metastases	metastasis	NNS
cord-000248-zueoyesj	121	8	values	value	NNS
cord-000248-zueoyesj	121	9	of	of	IN
cord-000248-zueoyesj	121	10	normal	normal	JJ
cord-000248-zueoyesj	121	11	samples	sample	NNS
cord-000248-zueoyesj	121	12	tend	tend	VBP
cord-000248-zueoyesj	121	13	to	to	TO
cord-000248-zueoyesj	121	14	be	be	VB
cord-000248-zueoyesj	121	15	higher	high	JJR
cord-000248-zueoyesj	121	16	than	than	IN
cord-000248-zueoyesj	121	17	most	most	JJS
cord-000248-zueoyesj	121	18	of	of	IN
cord-000248-zueoyesj	121	19	the	the	DT
cord-000248-zueoyesj	121	20	metastasis	metastasis	NN
cord-000248-zueoyesj	121	21	samples	sample	NNS
cord-000248-zueoyesj	121	22	(	(	-LRB-
cord-000248-zueoyesj	121	23	with	with	IN
cord-000248-zueoyesj	121	24	the	the	DT
cord-000248-zueoyesj	121	25	exception	exception	NN
cord-000248-zueoyesj	121	26	of	of	IN
cord-000248-zueoyesj	121	27	only	only	RB
cord-000248-zueoyesj	121	28	one	one	CD
cord-000248-zueoyesj	121	29	)	)	-RRB-
cord-000248-zueoyesj	121	30	.	.	.
cord-000248-zueoyesj	122	1	Figure	figure	NN
cord-000248-zueoyesj	122	2	2	2	CD
cord-000248-zueoyesj	122	3	shows	show	VBZ
cord-000248-zueoyesj	122	4	a	a	DT
cord-000248-zueoyesj	122	5	gradual	gradual	JJ
cord-000248-zueoyesj	122	6	progression	progression	NN
cord-000248-zueoyesj	122	7	of	of	IN
cord-000248-zueoyesj	122	8	the	the	DT
cord-000248-zueoyesj	122	9	samples	sample	NNS
cord-000248-zueoyesj	122	10	positions	position	NNS
cord-000248-zueoyesj	122	11	on	on	IN
cord-000248-zueoyesj	122	12	this	this	DT
cord-000248-zueoyesj	122	13	plane	plane	NN
cord-000248-zueoyesj	122	14	from	from	IN
cord-000248-zueoyesj	122	15	a	a	DT
cord-000248-zueoyesj	122	16	well	well	RB
cord-000248-zueoyesj	122	17	-	-	HYPH
cord-000248-zueoyesj	122	18	differentiated	differentiate	VBN
cord-000248-zueoyesj	122	19	tissue	tissue	NN
cord-000248-zueoyesj	122	20	type	type	NN
cord-000248-zueoyesj	122	21	specific	specific	JJ
cord-000248-zueoyesj	122	22	profile	profile	NN
cord-000248-zueoyesj	122	23	,	,	,
cord-000248-zueoyesj	122	24	first	first	RB
cord-000248-zueoyesj	122	25	to	to	IN
cord-000248-zueoyesj	122	26	a	a	DT
cord-000248-zueoyesj	122	27	more	more	RBR
cord-000248-zueoyesj	122	28	heterogeneous	heterogeneous	JJ
cord-000248-zueoyesj	122	29	primary	primary	JJ
cord-000248-zueoyesj	122	30	tumor	tumor	NN
cord-000248-zueoyesj	122	31	cluster	cluster	NN
cord-000248-zueoyesj	122	32	,	,	,
cord-000248-zueoyesj	122	33	and	and	CC
cord-000248-zueoyesj	122	34	finally	finally	RB
cord-000248-zueoyesj	122	35	to	to	IN
cord-000248-zueoyesj	122	36	an	an	DT
cord-000248-zueoyesj	122	37	even	even	RB
cord-000248-zueoyesj	122	38	less	less	RBR
cord-000248-zueoyesj	122	39	differentiated	differentiated	JJ
cord-000248-zueoyesj	122	40	metastatic	metastatic	JJ
cord-000248-zueoyesj	122	41	profile	profile	NN
cord-000248-zueoyesj	122	42	.	.	.
cord-000248-zueoyesj	123	1	The	the	DT
cord-000248-zueoyesj	123	2	result	result	NN
cord-000248-zueoyesj	123	3	presented	present	VBN
cord-000248-zueoyesj	123	4	in	in	IN
cord-000248-zueoyesj	123	5	Figure	figure	NN
cord-000248-zueoyesj	123	6	2	2	CD
cord-000248-zueoyesj	123	7	shows	show	VBZ
cord-000248-zueoyesj	123	8	that	that	IN
cord-000248-zueoyesj	123	9	the	the	DT
cord-000248-zueoyesj	123	10	prostate	prostate	NN
cord-000248-zueoyesj	123	11	cancer	cancer	NN
cord-000248-zueoyesj	123	12	samples	sample	NNS
cord-000248-zueoyesj	123	13	,	,	,
cord-000248-zueoyesj	123	14	which	which	WDT
cord-000248-zueoyesj	123	15	are	be	VBP
cord-000248-zueoyesj	123	16	not	not	RB
cord-000248-zueoyesj	123	17	metastases	metastasis	NNS
cord-000248-zueoyesj	123	18	and	and	CC
cord-000248-zueoyesj	123	19	therefore	therefore	RB
cord-000248-zueoyesj	123	20	could	could	MD
cord-000248-zueoyesj	123	21	have	have	VB
cord-000248-zueoyesj	123	22	been	be	VBN
cord-000248-zueoyesj	123	23	scattered	scatter	VBN
cord-000248-zueoyesj	123	24	anywhere	anywhere	RB
cord-000248-zueoyesj	123	25	on	on	IN
cord-000248-zueoyesj	123	26	the	the	DT
cord-000248-zueoyesj	123	27	plane	plane	NN
cord-000248-zueoyesj	123	28	,	,	,
cord-000248-zueoyesj	123	29	are	be	VBP
cord-000248-zueoyesj	123	30	clustered	cluster	VBN
cord-000248-zueoyesj	123	31	on	on	IN
cord-000248-zueoyesj	123	32	a	a	DT
cord-000248-zueoyesj	123	33	particular	particular	JJ
cord-000248-zueoyesj	123	34	confined	confine	VBN
cord-000248-zueoyesj	123	35	area	area	NN
cord-000248-zueoyesj	123	36	between	between	IN
cord-000248-zueoyesj	123	37	the	the	DT
cord-000248-zueoyesj	123	38	two	two	CD
cord-000248-zueoyesj	123	39	other	other	JJ
cord-000248-zueoyesj	123	40	groups	group	NNS
cord-000248-zueoyesj	123	41	.	.	.
cord-000248-zueoyesj	124	1	We	-PRON-	PRP
cord-000248-zueoyesj	124	2	understand	understand	VBP
cord-000248-zueoyesj	124	3	that	that	IN
cord-000248-zueoyesj	124	4	there	there	EX
cord-000248-zueoyesj	124	5	are	be	VBP
cord-000248-zueoyesj	124	6	reasons	reason	NNS
cord-000248-zueoyesj	124	7	to	to	TO
cord-000248-zueoyesj	124	8	be	be	VB
cord-000248-zueoyesj	124	9	sceptical	sceptical	JJ
cord-000248-zueoyesj	124	10	about	about	IN
cord-000248-zueoyesj	124	11	this	this	DT
cord-000248-zueoyesj	124	12	result	result	NN
cord-000248-zueoyesj	124	13	being	be	VBG
cord-000248-zueoyesj	124	14	not	not	RB
cord-000248-zueoyesj	124	15	just	just	RB
cord-000248-zueoyesj	124	16	a	a	DT
cord-000248-zueoyesj	124	17	simple	simple	JJ
cord-000248-zueoyesj	124	18	consequence	consequence	NN
cord-000248-zueoyesj	124	19	of	of	IN
cord-000248-zueoyesj	124	20	the	the	DT
cord-000248-zueoyesj	124	21	gene	gene	NN
cord-000248-zueoyesj	124	22	selection	selection	NN
cord-000248-zueoyesj	124	23	process	process	NN
cord-000248-zueoyesj	124	24	used	use	VBN
cord-000248-zueoyesj	124	25	by	by	IN
cord-000248-zueoyesj	124	26	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	124	27	et	et	FW
cord-000248-zueoyesj	124	28	al	al	NNP
cord-000248-zueoyesj	124	29	.	.	.
cord-000248-zueoyesj	125	1	For	for	IN
cord-000248-zueoyesj	125	2	example	example	NN
cord-000248-zueoyesj	125	3	,	,	,
cord-000248-zueoyesj	125	4	if	if	IN
cord-000248-zueoyesj	125	5	we	-PRON-	PRP
cord-000248-zueoyesj	125	6	assume	assume	VBP
cord-000248-zueoyesj	125	7	that	that	IN
cord-000248-zueoyesj	125	8	the	the	DT
cord-000248-zueoyesj	125	9	5,153	5,153	CD
cord-000248-zueoyesj	125	10	probes	probe	NNS
cord-000248-zueoyesj	125	11	singled	single	VBN
cord-000248-zueoyesj	125	12	out	out	RP
cord-000248-zueoyesj	125	13	by	by	IN
cord-000248-zueoyesj	125	14	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	125	15	et	et	FW
cord-000248-zueoyesj	125	16	al	al	NNP
cord-000248-zueoyesj	125	17	.	.	.
cord-000248-zueoyesj	126	1	in	in	IN
cord-000248-zueoyesj	126	2	their	-PRON-	PRP$
cord-000248-zueoyesj	126	3	figure	figure	NN
cord-000248-zueoyesj	126	4	one	one	CD
cord-000248-zueoyesj	126	5	of	of	IN
cord-000248-zueoyesj	126	6	Ref	Ref	NNP
cord-000248-zueoyesj	126	7	.	.	.
cord-000248-zueoyesj	127	1	[	[	-LRB-
cord-000248-zueoyesj	127	2	44	44	CD
cord-000248-zueoyesj	127	3	]	]	-RRB-
cord-000248-zueoyesj	128	1	(	(	-LRB-
cord-000248-zueoyesj	128	2	and	and	CC
cord-000248-zueoyesj	128	3	that	that	DT
cord-000248-zueoyesj	128	4	constitute	constitute	VBP
cord-000248-zueoyesj	128	5	our	-PRON-	PRP$
cord-000248-zueoyesj	128	6	original	original	JJ
cord-000248-zueoyesj	128	7	data	datum	NNS
cord-000248-zueoyesj	128	8	)	)	-RRB-
cord-000248-zueoyesj	128	9	have	have	VBP
cord-000248-zueoyesj	128	10	been	be	VBN
cord-000248-zueoyesj	128	11	selected	select	VBN
cord-000248-zueoyesj	128	12	with	with	IN
cord-000248-zueoyesj	128	13	a	a	DT
cord-000248-zueoyesj	128	14	supervised	supervise	VBN
cord-000248-zueoyesj	128	15	method	method	NN
cord-000248-zueoyesj	128	16	that	that	WDT
cord-000248-zueoyesj	128	17	try	try	VBP
cord-000248-zueoyesj	128	18	to	to	TO
cord-000248-zueoyesj	128	19	distinguish	distinguish	VB
cord-000248-zueoyesj	128	20	between	between	IN
cord-000248-zueoyesj	128	21	normal	normal	JJ
cord-000248-zueoyesj	128	22	and	and	CC
cord-000248-zueoyesj	128	23	metastases	metastasis	NNS
cord-000248-zueoyesj	128	24	,	,	,
cord-000248-zueoyesj	128	25	then	then	RB
cord-000248-zueoyesj	128	26	the	the	DT
cord-000248-zueoyesj	128	27	relative	relative	JJ
cord-000248-zueoyesj	128	28	position	position	NN
cord-000248-zueoyesj	128	29	of	of	IN
cord-000248-zueoyesj	128	30	normal	normal	JJ
cord-000248-zueoyesj	128	31	and	and	CC
cord-000248-zueoyesj	128	32	metastases	metastasis	NNS
cord-000248-zueoyesj	128	33	samples	sample	NNS
cord-000248-zueoyesj	128	34	is	be	VBZ
cord-000248-zueoyesj	128	35	perhaps	perhaps	RB
cord-000248-zueoyesj	128	36	something	something	NN
cord-000248-zueoyesj	128	37	to	to	TO
cord-000248-zueoyesj	128	38	be	be	VB
cord-000248-zueoyesj	128	39	expected	expect	VBN
cord-000248-zueoyesj	128	40	.	.	.
cord-000248-zueoyesj	129	1	However	however	RB
cord-000248-zueoyesj	129	2	,	,	,
cord-000248-zueoyesj	129	3	even	even	RB
cord-000248-zueoyesj	129	4	under	under	IN
cord-000248-zueoyesj	129	5	that	that	DT
cord-000248-zueoyesj	129	6	assumption	assumption	NN
cord-000248-zueoyesj	129	7	,	,	,
cord-000248-zueoyesj	129	8	what	what	WP
cord-000248-zueoyesj	129	9	is	be	VBZ
cord-000248-zueoyesj	129	10	not	not	RB
cord-000248-zueoyesj	129	11	expected	expect	VBN
cord-000248-zueoyesj	129	12	is	be	VBZ
cord-000248-zueoyesj	129	13	the	the	DT
cord-000248-zueoyesj	129	14	position	position	NN
cord-000248-zueoyesj	129	15	of	of	IN
cord-000248-zueoyesj	129	16	all	all	DT
cord-000248-zueoyesj	129	17	primary	primary	JJ
cord-000248-zueoyesj	129	18	tumor	tumor	NN
cord-000248-zueoyesj	129	19	prostate	prostate	NN
cord-000248-zueoyesj	129	20	cancer	cancer	NN
cord-000248-zueoyesj	129	21	samples	sample	NNS
cord-000248-zueoyesj	129	22	,	,	,
cord-000248-zueoyesj	129	23	linking	link	VBG
cord-000248-zueoyesj	129	24	the	the	DT
cord-000248-zueoyesj	129	25	normal	normal	JJ
cord-000248-zueoyesj	129	26	cluster	cluster	NN
cord-000248-zueoyesj	129	27	of	of	IN
cord-000248-zueoyesj	129	28	samples	sample	NNS
cord-000248-zueoyesj	129	29	with	with	IN
cord-000248-zueoyesj	129	30	the	the	DT
cord-000248-zueoyesj	129	31	metastases	metastasis	NNS
cord-000248-zueoyesj	129	32	one	one	CD
cord-000248-zueoyesj	129	33	.	.	.
cord-000248-zueoyesj	130	1	Note	note	VB
cord-000248-zueoyesj	130	2	that	that	IN
cord-000248-zueoyesj	130	3	the	the	DT
cord-000248-zueoyesj	130	4	definition	definition	NN
cord-000248-zueoyesj	130	5	of	of	IN
cord-000248-zueoyesj	130	6	both	both	CC
cord-000248-zueoyesj	130	7	the	the	DT
cord-000248-zueoyesj	130	8	M	M	NNP
cord-000248-zueoyesj	130	9	-	-	HYPH
cord-000248-zueoyesj	130	10	Normal	Normal	NNP
cord-000248-zueoyesj	130	11	and	and	CC
cord-000248-zueoyesj	130	12	M	M	NNP
cord-000248-zueoyesj	130	13	-	-	HYPH
cord-000248-zueoyesj	130	14	Metastases	Metastases	NNP
cord-000248-zueoyesj	130	15	measures	measure	NNS
cord-000248-zueoyesj	130	16	do	do	VBP
cord-000248-zueoyesj	130	17	not	not	RB
cord-000248-zueoyesj	130	18	use	use	VB
cord-000248-zueoyesj	130	19	any	any	DT
cord-000248-zueoyesj	130	20	information	information	NN
cord-000248-zueoyesj	130	21	from	from	IN
cord-000248-zueoyesj	130	22	the	the	DT
cord-000248-zueoyesj	130	23	primary	primary	JJ
cord-000248-zueoyesj	130	24	tumor	tumor	NN
cord-000248-zueoyesj	130	25	prostate	prostate	NN
cord-000248-zueoyesj	130	26	cancer	cancer	NN
cord-000248-zueoyesj	130	27	samples	sample	NNS
cord-000248-zueoyesj	130	28	,	,	,
cord-000248-zueoyesj	130	29	so	so	IN
cord-000248-zueoyesj	130	30	the	the	DT
cord-000248-zueoyesj	130	31	location	location	NN
cord-000248-zueoyesj	130	32	of	of	IN
cord-000248-zueoyesj	130	33	these	these	DT
cord-000248-zueoyesj	130	34	samples	sample	NNS
cord-000248-zueoyesj	130	35	between	between	IN
cord-000248-zueoyesj	130	36	the	the	DT
cord-000248-zueoyesj	130	37	normal	normal	JJ
cord-000248-zueoyesj	130	38	cluster	cluster	NN
cord-000248-zueoyesj	130	39	and	and	CC
cord-000248-zueoyesj	130	40	the	the	DT
cord-000248-zueoyesj	130	41	metastases	metastasis	NNS
cord-000248-zueoyesj	130	42	,	,	,
cord-000248-zueoyesj	130	43	bridging	bridge	VBG
cord-000248-zueoyesj	130	44	them	-PRON-	PRP
cord-000248-zueoyesj	130	45	naturally	naturally	RB
cord-000248-zueoyesj	130	46	is	be	VBZ
cord-000248-zueoyesj	130	47	something	something	NN
cord-000248-zueoyesj	130	48	to	to	TO
cord-000248-zueoyesj	130	49	highlight	highlight	VB
cord-000248-zueoyesj	130	50	.	.	.
cord-000248-zueoyesj	131	1	Together	together	RB
cord-000248-zueoyesj	131	2	with	with	IN
cord-000248-zueoyesj	131	3	Figure	figure	NN
cord-000248-zueoyesj	131	4	1	1	CD
cord-000248-zueoyesj	131	5	,	,	,
cord-000248-zueoyesj	131	6	it	-PRON-	PRP
cord-000248-zueoyesj	131	7	gives	give	VBZ
cord-000248-zueoyesj	131	8	evidence	evidence	NN
cord-000248-zueoyesj	131	9	that	that	WDT
cord-000248-zueoyesj	131	10	supports	support	VBZ
cord-000248-zueoyesj	131	11	the	the	DT
cord-000248-zueoyesj	131	12	working	work	VBG
cord-000248-zueoyesj	131	13	hypothesis	hypothesis	NN
cord-000248-zueoyesj	131	14	that	that	IN
cord-000248-zueoyesj	131	15	a	a	DT
cord-000248-zueoyesj	131	16	gradual	gradual	JJ
cord-000248-zueoyesj	131	17	'	'	''
cord-000248-zueoyesj	131	18	'	'	``
cord-000248-zueoyesj	131	19	progression	progression	NN
cord-000248-zueoyesj	131	20	'	'	''
cord-000248-zueoyesj	131	21	'	'	''
cord-000248-zueoyesj	131	22	occurs	occur	NNS
cord-000248-zueoyesj	131	23	,	,	,
cord-000248-zueoyesj	131	24	from	from	IN
cord-000248-zueoyesj	131	25	the	the	DT
cord-000248-zueoyesj	131	26	normal	normal	JJ
cord-000248-zueoyesj	131	27	tissue	tissue	NN
cord-000248-zueoyesj	131	28	specific	specific	JJ
cord-000248-zueoyesj	131	29	profile	profile	NN
cord-000248-zueoyesj	131	30	to	to	IN
cord-000248-zueoyesj	131	31	the	the	DT
cord-000248-zueoyesj	131	32	metastasis	metastasis	NN
cord-000248-zueoyesj	131	33	one	one	CD
cord-000248-zueoyesj	131	34	.	.	.
cord-000248-zueoyesj	132	1	Indeed	indeed	RB
cord-000248-zueoyesj	132	2	,	,	,
cord-000248-zueoyesj	132	3	following	follow	VBG
cord-000248-zueoyesj	132	4	our	-PRON-	PRP$
cord-000248-zueoyesj	132	5	line	line	NN
cord-000248-zueoyesj	132	6	of	of	IN
cord-000248-zueoyesj	132	7	argument	argument	NN
cord-000248-zueoyesj	132	8	,	,	,
cord-000248-zueoyesj	132	9	Figure	figure	NN
cord-000248-zueoyesj	132	10	2	2	CD
cord-000248-zueoyesj	132	11	has	have	VBZ
cord-000248-zueoyesj	132	12	even	even	RB
cord-000248-zueoyesj	132	13	more	more	JJR
cord-000248-zueoyesj	132	14	relevance	relevance	NN
cord-000248-zueoyesj	132	15	when	when	WRB
cord-000248-zueoyesj	132	16	we	-PRON-	PRP
cord-000248-zueoyesj	132	17	highlight	highlight	VBP
cord-000248-zueoyesj	132	18	the	the	DT
cord-000248-zueoyesj	132	19	fact	fact	NN
cord-000248-zueoyesj	132	20	that	that	IN
cord-000248-zueoyesj	132	21	the	the	DT
cord-000248-zueoyesj	132	22	5,153	5,153	CD
cord-000248-zueoyesj	132	23	probes	probe	NNS
cord-000248-zueoyesj	132	24	have	have	VBP
cord-000248-zueoyesj	132	25	not	not	RB
cord-000248-zueoyesj	132	26	been	be	VBN
cord-000248-zueoyesj	132	27	selected	select	VBN
cord-000248-zueoyesj	132	28	with	with	IN
cord-000248-zueoyesj	132	29	a	a	DT
cord-000248-zueoyesj	132	30	supervised	supervise	VBN
cord-000248-zueoyesj	132	31	method	method	NN
cord-000248-zueoyesj	132	32	.	.	.
cord-000248-zueoyesj	133	1	The	the	DT
cord-000248-zueoyesj	133	2	authors	author	NNS
cord-000248-zueoyesj	133	3	say	say	VBP
cord-000248-zueoyesj	133	4	that	that	IN
cord-000248-zueoyesj	133	5	the	the	DT
cord-000248-zueoyesj	133	6	only	only	JJ
cord-000248-zueoyesj	133	7	selection	selection	NN
cord-000248-zueoyesj	133	8	criteria	criterion	NNS
cord-000248-zueoyesj	133	9	was	be	VBD
cord-000248-zueoyesj	133	10	to	to	TO
cord-000248-zueoyesj	133	11	single	single	VB
cord-000248-zueoyesj	133	12	out	out	RP
cord-000248-zueoyesj	133	13	the	the	DT
cord-000248-zueoyesj	133	14	5,153	5,153	CD
cord-000248-zueoyesj	133	15	cDNAs	cDNAs	NNPS
cord-000248-zueoyesj	133	16	whose	whose	WP$
cord-000248-zueoyesj	133	17	expression	expression	NN
cord-000248-zueoyesj	133	18	varied	vary	VBD
cord-000248-zueoyesj	133	19	most	most	RBS
cord-000248-zueoyesj	133	20	across	across	IN
cord-000248-zueoyesj	133	21	samples	sample	NNS
cord-000248-zueoyesj	133	22	.	.	.
cord-000248-zueoyesj	134	1	In	in	IN
cord-000248-zueoyesj	134	2	the	the	DT
cord-000248-zueoyesj	134	3	supplementary	supplementary	JJ
cord-000248-zueoyesj	134	4	notes	note	NNS
cord-000248-zueoyesj	134	5	of	of	IN
cord-000248-zueoyesj	134	6	their	-PRON-	PRP$
cord-000248-zueoyesj	134	7	paper	paper	NN
cord-000248-zueoyesj	134	8	the	the	DT
cord-000248-zueoyesj	134	9	authors	author	NNS
cord-000248-zueoyesj	134	10	say	say	VBP
cord-000248-zueoyesj	134	11	:	:	:
cord-000248-zueoyesj	134	12	'	'	''
cord-000248-zueoyesj	134	13	'	'	''
cord-000248-zueoyesj	134	14	We	-PRON-	PRP
cord-000248-zueoyesj	134	15	included	include	VBD
cord-000248-zueoyesj	134	16	for	for	IN
cord-000248-zueoyesj	134	17	subsequent	subsequent	JJ
cord-000248-zueoyesj	134	18	analysis	analysis	NN
cord-000248-zueoyesj	134	19	only	only	RB
cord-000248-zueoyesj	134	20	well	well	RB
cord-000248-zueoyesj	134	21	measured	measure	VBN
cord-000248-zueoyesj	134	22	genes	gene	NNS
cord-000248-zueoyesj	134	23	whose	whose	WP$
cord-000248-zueoyesj	134	24	expression	expression	NN
cord-000248-zueoyesj	134	25	varied	vary	VBN
cord-000248-zueoyesj	134	26	,	,	,
cord-000248-zueoyesj	134	27	as	as	IN
cord-000248-zueoyesj	134	28	determined	determine	VBN
cord-000248-zueoyesj	134	29	by	by	IN
cord-000248-zueoyesj	134	30	(	(	-LRB-
cord-000248-zueoyesj	134	31	1	1	CD
cord-000248-zueoyesj	134	32	)	)	-RRB-
cord-000248-zueoyesj	134	33	signal	signal	JJ
cord-000248-zueoyesj	134	34	intensity	intensity	NN
cord-000248-zueoyesj	134	35	over	over	IN
cord-000248-zueoyesj	134	36	background	background	NN
cord-000248-zueoyesj	134	37	.1.5-fold	.1.5-fold	.
cord-000248-zueoyesj	135	1	in	in	IN
cord-000248-zueoyesj	135	2	both	both	DT
cord-000248-zueoyesj	135	3	test	test	NN
cord-000248-zueoyesj	135	4	and	and	CC
cord-000248-zueoyesj	135	5	reference	reference	NN
cord-000248-zueoyesj	135	6	channels	channel	NNS
cord-000248-zueoyesj	135	7	in	in	IN
cord-000248-zueoyesj	135	8	at	at	RB
cord-000248-zueoyesj	135	9	least	least	RBS
cord-000248-zueoyesj	135	10	75	75	CD
cord-000248-zueoyesj	135	11	%	%	NN
cord-000248-zueoyesj	135	12	of	of	IN
cord-000248-zueoyesj	135	13	samples	sample	NNS
cord-000248-zueoyesj	135	14	,	,	,
cord-000248-zueoyesj	135	15	and	and	CC
cord-000248-zueoyesj	135	16	(	(	-LRB-
cord-000248-zueoyesj	135	17	2	2	LS
cord-000248-zueoyesj	135	18	)	)	-RRB-
cord-000248-zueoyesj	135	19	3-fold	3-fold	CD
cord-000248-zueoyesj	135	20	ratio	ratio	NN
cord-000248-zueoyesj	135	21	variation	variation	NN
cord-000248-zueoyesj	135	22	from	from	IN
cord-000248-zueoyesj	135	23	the	the	DT
cord-000248-zueoyesj	135	24	mean	mean	NN
cord-000248-zueoyesj	135	25	in	in	IN
cord-000248-zueoyesj	135	26	at	at	RB
cord-000248-zueoyesj	135	27	least	least	RBS
cord-000248-zueoyesj	135	28	two	two	CD
cord-000248-zueoyesj	135	29	samples	sample	NNS
cord-000248-zueoyesj	135	30	;	;	:
cord-000248-zueoyesj	135	31	5,153	5,153	CD
cord-000248-zueoyesj	135	32	genes	gene	NNS
cord-000248-zueoyesj	135	33	met	meet	VBD
cord-000248-zueoyesj	135	34	these	these	DT
cord-000248-zueoyesj	135	35	criteria	criterion	NNS
cord-000248-zueoyesj	135	36	.	.	.
cord-000248-zueoyesj	135	37	'	'	''
cord-000248-zueoyesj	135	38	'	'	''
cord-000248-zueoyesj	136	1	As	as	IN
cord-000248-zueoyesj	136	2	a	a	DT
cord-000248-zueoyesj	136	3	consequence	consequence	NN
cord-000248-zueoyesj	136	4	,	,	,
cord-000248-zueoyesj	136	5	Figure	figure	NN
cord-000248-zueoyesj	136	6	2	2	CD
cord-000248-zueoyesj	136	7	has	have	VBZ
cord-000248-zueoyesj	136	8	been	be	VBN
cord-000248-zueoyesj	136	9	generated	generate	VBN
cord-000248-zueoyesj	136	10	without	without	IN
cord-000248-zueoyesj	136	11	class	class	NN
cord-000248-zueoyesj	136	12	selection	selection	NN
cord-000248-zueoyesj	136	13	bias	bias	NN
cord-000248-zueoyesj	136	14	only	only	RB
cord-000248-zueoyesj	136	15	using	use	VBG
cord-000248-zueoyesj	136	16	the	the	DT
cord-000248-zueoyesj	136	17	genes	gene	NNS
cord-000248-zueoyesj	136	18	that	that	WDT
cord-000248-zueoyesj	136	19	have	have	VBP
cord-000248-zueoyesj	136	20	the	the	DT
cord-000248-zueoyesj	136	21	most	most	RBS
cord-000248-zueoyesj	136	22	varied	varied	JJ
cord-000248-zueoyesj	136	23	expression	expression	NN
cord-000248-zueoyesj	136	24	pattern	pattern	NN
cord-000248-zueoyesj	136	25	.	.	.
cord-000248-zueoyesj	137	1	We	-PRON-	PRP
cord-000248-zueoyesj	137	2	now	now	RB
cord-000248-zueoyesj	137	3	turn	turn	VBP
cord-000248-zueoyesj	137	4	to	to	IN
cord-000248-zueoyesj	137	5	another	another	DT
cord-000248-zueoyesj	137	6	aspect	aspect	NN
cord-000248-zueoyesj	137	7	of	of	IN
cord-000248-zueoyesj	137	8	the	the	DT
cord-000248-zueoyesj	137	9	statistical	statistical	JJ
cord-000248-zueoyesj	137	10	complexity	complexity	NN
cord-000248-zueoyesj	137	11	and	and	CC
cord-000248-zueoyesj	137	12	entropy	entropy	NN
cord-000248-zueoyesj	137	13	analysis	analysis	NN
cord-000248-zueoyesj	137	14	.	.	.
cord-000248-zueoyesj	138	1	We	-PRON-	PRP
cord-000248-zueoyesj	138	2	note	note	VBP
cord-000248-zueoyesj	138	3	that	that	IN
cord-000248-zueoyesj	138	4	Figure	figure	NN
cord-000248-zueoyesj	138	5	2	2	CD
cord-000248-zueoyesj	138	6	shows	show	VBZ
cord-000248-zueoyesj	138	7	that	that	IN
cord-000248-zueoyesj	138	8	the	the	DT
cord-000248-zueoyesj	138	9	metastases	metastasis	NNS
cord-000248-zueoyesj	138	10	samples	sample	NNS
cord-000248-zueoyesj	138	11	have	have	VBP
cord-000248-zueoyesj	138	12	a	a	DT
cord-000248-zueoyesj	138	13	clear	clear	JJ
cord-000248-zueoyesj	138	14	reduction	reduction	NN
cord-000248-zueoyesj	138	15	on	on	IN
cord-000248-zueoyesj	138	16	Normalized	Normalized	NNP
cord-000248-zueoyesj	138	17	Shannon	Shannon	NNP
cord-000248-zueoyesj	138	18	Entropy	Entropy	NNP
cord-000248-zueoyesj	138	19	in	in	IN
cord-000248-zueoyesj	138	20	comparison	comparison	NN
cord-000248-zueoyesj	138	21	with	with	IN
cord-000248-zueoyesj	138	22	the	the	DT
cord-000248-zueoyesj	138	23	values	value	NNS
cord-000248-zueoyesj	138	24	observed	observe	VBN
cord-000248-zueoyesj	138	25	for	for	IN
cord-000248-zueoyesj	138	26	the	the	DT
cord-000248-zueoyesj	138	27	normal	normal	JJ
cord-000248-zueoyesj	138	28	samples	sample	NNS
cord-000248-zueoyesj	138	29	.	.	.
cord-000248-zueoyesj	139	1	At	at	IN
cord-000248-zueoyesj	139	2	the	the	DT
cord-000248-zueoyesj	139	3	same	same	JJ
cord-000248-zueoyesj	139	4	time	time	NN
cord-000248-zueoyesj	139	5	,	,	,
cord-000248-zueoyesj	139	6	metastases	metastasis	NNS
cord-000248-zueoyesj	139	7	samples	sample	NNS
cord-000248-zueoyesj	139	8	,	,	,
cord-000248-zueoyesj	139	9	as	as	IN
cord-000248-zueoyesj	139	10	expected	expect	VBN
cord-000248-zueoyesj	139	11	,	,	,
cord-000248-zueoyesj	139	12	have	have	VBP
cord-000248-zueoyesj	139	13	higher	high	JJR
cord-000248-zueoyesj	139	14	Mnormal	Mnormal	NNP
cord-000248-zueoyesj	139	15	complexity	complexity	NN
cord-000248-zueoyesj	139	16	than	than	IN
cord-000248-zueoyesj	139	17	the	the	DT
cord-000248-zueoyesj	139	18	normal	normal	JJ
cord-000248-zueoyesj	139	19	samples	sample	NNS
cord-000248-zueoyesj	139	20	(	(	-LRB-
cord-000248-zueoyesj	139	21	Figure	figure	NN
cord-000248-zueoyesj	139	22	2	2	CD
cord-000248-zueoyesj	139	23	)	)	-RRB-
cord-000248-zueoyesj	139	24	.	.	.
cord-000248-zueoyesj	140	1	It	-PRON-	PRP
cord-000248-zueoyesj	140	2	is	be	VBZ
cord-000248-zueoyesj	140	3	then	then	RB
cord-000248-zueoyesj	140	4	interesting	interesting	JJ
cord-000248-zueoyesj	140	5	to	to	TO
cord-000248-zueoyesj	140	6	evaluate	evaluate	VB
cord-000248-zueoyesj	140	7	the	the	DT
cord-000248-zueoyesj	140	8	value	value	NN
cord-000248-zueoyesj	140	9	of	of	IN
cord-000248-zueoyesj	140	10	the	the	DT
cord-000248-zueoyesj	140	11	Jensen	Jensen	NNP
cord-000248-zueoyesj	140	12	-	-	HYPH
cord-000248-zueoyesj	140	13	Shannon	Shannon	NNP
cord-000248-zueoyesj	140	14	divergence	divergence	NN
cord-000248-zueoyesj	140	15	of	of	IN
cord-000248-zueoyesj	140	16	these	these	DT
cord-000248-zueoyesj	140	17	samples	sample	NNS
cord-000248-zueoyesj	140	18	and	and	CC
cord-000248-zueoyesj	140	19	to	to	TO
cord-000248-zueoyesj	140	20	identify	identify	VB
cord-000248-zueoyesj	140	21	the	the	DT
cord-000248-zueoyesj	140	22	genes	gene	NNS
cord-000248-zueoyesj	140	23	that	that	WDT
cord-000248-zueoyesj	140	24	most	most	RBS
cord-000248-zueoyesj	140	25	correlate	correlate	VBP
cord-000248-zueoyesj	140	26	with	with	IN
cord-000248-zueoyesj	140	27	the	the	DT
cord-000248-zueoyesj	140	28	variations	variation	NNS
cord-000248-zueoyesj	140	29	of	of	IN
cord-000248-zueoyesj	140	30	Jensen	Jensen	NNP
cord-000248-zueoyesj	140	31	-	-	HYPH
cord-000248-zueoyesj	140	32	Shannon	Shannon	NNP
cord-000248-zueoyesj	140	33	divergence	divergence	NN
cord-000248-zueoyesj	140	34	to	to	TO
cord-000248-zueoyesj	140	35	quantify	quantify	VB
cord-000248-zueoyesj	140	36	one	one	CD
cord-000248-zueoyesj	140	37	of	of	IN
cord-000248-zueoyesj	140	38	the	the	DT
cord-000248-zueoyesj	140	39	factors	factor	NNS
cord-000248-zueoyesj	140	40	that	that	WDT
cord-000248-zueoyesj	140	41	is	be	VBZ
cord-000248-zueoyesj	140	42	related	relate	VBN
cord-000248-zueoyesj	140	43	to	to	IN
cord-000248-zueoyesj	140	44	the	the	DT
cord-000248-zueoyesj	140	45	statistical	statistical	JJ
cord-000248-zueoyesj	140	46	complexity	complexity	NN
cord-000248-zueoyesj	140	47	changes	change	NNS
cord-000248-zueoyesj	140	48	.	.	.
cord-000248-zueoyesj	141	1	We	-PRON-	PRP
cord-000248-zueoyesj	141	2	have	have	VBP
cord-000248-zueoyesj	141	3	computed	compute	VBN
cord-000248-zueoyesj	141	4	the	the	DT
cord-000248-zueoyesj	141	5	correlation	correlation	NN
cord-000248-zueoyesj	141	6	of	of	IN
cord-000248-zueoyesj	141	7	the	the	DT
cord-000248-zueoyesj	141	8	gene	gene	NN
cord-000248-zueoyesj	141	9	expression	expression	NN
cord-000248-zueoyesj	141	10	profile	profile	NN
cord-000248-zueoyesj	141	11	corresponding	correspond	VBG
cord-000248-zueoyesj	141	12	to	to	IN
cord-000248-zueoyesj	141	13	each	each	DT
cord-000248-zueoyesj	141	14	of	of	IN
cord-000248-zueoyesj	141	15	the	the	DT
cord-000248-zueoyesj	141	16	5,123	5,123	CD
cord-000248-zueoyesj	141	17	probes	probe	NNS
cord-000248-zueoyesj	141	18	.	.	.
cord-000248-zueoyesj	142	1	For	for	IN
cord-000248-zueoyesj	142	2	each	each	DT
cord-000248-zueoyesj	142	3	of	of	IN
cord-000248-zueoyesj	142	4	the	the	DT
cord-000248-zueoyesj	142	5	5,123	5,123	CD
cord-000248-zueoyesj	142	6	probes	probe	NNS
cord-000248-zueoyesj	142	7	,	,	,
cord-000248-zueoyesj	142	8	we	-PRON-	PRP
cord-000248-zueoyesj	142	9	computed	compute	VBD
cord-000248-zueoyesj	142	10	both	both	CC
cord-000248-zueoyesj	142	11	the	the	DT
cord-000248-zueoyesj	142	12	Pearson	Pearson	NNP
cord-000248-zueoyesj	142	13	correlation	correlation	NN
cord-000248-zueoyesj	142	14	(	(	-LRB-
cord-000248-zueoyesj	142	15	x	x	NN
cord-000248-zueoyesj	142	16	-	-	NN
cord-000248-zueoyesj	142	17	axis	axis	NN
cord-000248-zueoyesj	142	18	of	of	IN
cord-000248-zueoyesj	142	19	Figure	figure	NN
cord-000248-zueoyesj	142	20	3	3	CD
cord-000248-zueoyesj	142	21	)	)	-RRB-
cord-000248-zueoyesj	142	22	and	and	CC
cord-000248-zueoyesj	142	23	the	the	DT
cord-000248-zueoyesj	142	24	Spearman	Spearman	NNP
cord-000248-zueoyesj	142	25	correlation	correlation	NN
cord-000248-zueoyesj	142	26	(	(	-LRB-
cord-000248-zueoyesj	142	27	y	y	NN
cord-000248-zueoyesj	142	28	-	-	HYPH
cord-000248-zueoyesj	142	29	axis	axis	NN
cord-000248-zueoyesj	142	30	of	of	IN
cord-000248-zueoyesj	142	31	Figure	figure	NN
cord-000248-zueoyesj	142	32	3	3	CD
cord-000248-zueoyesj	142	33	)	)	-RRB-
cord-000248-zueoyesj	142	34	of	of	IN
cord-000248-zueoyesj	142	35	each	each	DT
cord-000248-zueoyesj	142	36	probe	probe	NN
cord-000248-zueoyesj	142	37	profile	profile	NN
cord-000248-zueoyesj	142	38	with	with	IN
cord-000248-zueoyesj	142	39	the	the	DT
cord-000248-zueoyesj	142	40	Jensen	Jensen	NNP
cord-000248-zueoyesj	142	41	-	-	HYPH
cord-000248-zueoyesj	142	42	Shannon	Shannon	NNP
cord-000248-zueoyesj	142	43	divergence	divergence	NN
cord-000248-zueoyesj	142	44	having	have	VBG
cord-000248-zueoyesj	142	45	as	as	IN
cord-000248-zueoyesj	142	46	probability	probability	NN
cord-000248-zueoyesj	142	47	distribution	distribution	NN
cord-000248-zueoyesj	142	48	of	of	IN
cord-000248-zueoyesj	142	49	reference	reference	NN
cord-000248-zueoyesj	142	50	that	that	DT
cord-000248-zueoyesj	142	51	of	of	IN
cord-000248-zueoyesj	142	52	a	a	DT
cord-000248-zueoyesj	142	53	metastasis	metastasis	NN
cord-000248-zueoyesj	142	54	profile	profile	NN
cord-000248-zueoyesj	142	55	(	(	-LRB-
cord-000248-zueoyesj	142	56	these	these	DT
cord-000248-zueoyesj	142	57	values	value	NNS
cord-000248-zueoyesj	142	58	are	be	VBP
cord-000248-zueoyesj	142	59	called	call	VBN
cord-000248-zueoyesj	142	60	JSM2-Pearson	JSM2-Pearson	NNP
cord-000248-zueoyesj	142	61	and	and	CC
cord-000248-zueoyesj	142	62	JSM2-Spearman	JSM2-Spearman	NNP
cord-000248-zueoyesj	142	63	in	in	IN
cord-000248-zueoyesj	142	64	the	the	DT
cord-000248-zueoyesj	142	65	accompanying	accompany	VBG
cord-000248-zueoyesj	142	66	Excel	Excel	NNP
cord-000248-zueoyesj	142	67	file	file	NN
cord-000248-zueoyesj	142	68	provided	provide	VBN
cord-000248-zueoyesj	142	69	)	)	-RRB-
cord-000248-zueoyesj	142	70	.	.	.
cord-000248-zueoyesj	143	1	With	with	IN
cord-000248-zueoyesj	143	2	this	this	DT
cord-000248-zueoyesj	143	3	data	datum	NNS
cord-000248-zueoyesj	143	4	,	,	,
cord-000248-zueoyesj	143	5	we	-PRON-	PRP
cord-000248-zueoyesj	143	6	have	have	VBP
cord-000248-zueoyesj	143	7	produced	produce	VBN
cord-000248-zueoyesj	143	8	Figure	Figure	NNP
cord-000248-zueoyesj	143	9	3	3	CD
cord-000248-zueoyesj	143	10	,	,	,
cord-000248-zueoyesj	143	11	a	a	DT
cord-000248-zueoyesj	143	12	scatter	scatter	NN
cord-000248-zueoyesj	143	13	plot	plot	NN
cord-000248-zueoyesj	143	14	of	of	IN
cord-000248-zueoyesj	143	15	the	the	DT
cord-000248-zueoyesj	143	16	values	value	NNS
cord-000248-zueoyesj	143	17	associated	associate	VBN
cord-000248-zueoyesj	143	18	to	to	IN
cord-000248-zueoyesj	143	19	each	each	DT
cord-000248-zueoyesj	143	20	probe	probe	NN
cord-000248-zueoyesj	143	21	.	.	.
cord-000248-zueoyesj	144	1	In	in	IN
cord-000248-zueoyesj	144	2	this	this	DT
cord-000248-zueoyesj	144	3	figure	figure	NN
cord-000248-zueoyesj	144	4	,	,	,
cord-000248-zueoyesj	144	5	there	there	EX
cord-000248-zueoyesj	144	6	are	be	VBP
cord-000248-zueoyesj	144	7	two	two	CD
cord-000248-zueoyesj	144	8	probes	probe	NNS
cord-000248-zueoyesj	144	9	that	that	WDT
cord-000248-zueoyesj	144	10	are	be	VBP
cord-000248-zueoyesj	144	11	immediately	immediately	RB
cord-000248-zueoyesj	144	12	recognizable	recognizable	JJ
cord-000248-zueoyesj	144	13	by	by	IN
cord-000248-zueoyesj	144	14	any	any	DT
cord-000248-zueoyesj	144	15	cancer	cancer	NN
cord-000248-zueoyesj	144	16	researcher	researcher	NN
cord-000248-zueoyesj	144	17	,	,	,
cord-000248-zueoyesj	144	18	and	and	CC
cord-000248-zueoyesj	144	19	in	in	IN
cord-000248-zueoyesj	144	20	particular	particular	JJ
cord-000248-zueoyesj	144	21	for	for	IN
cord-000248-zueoyesj	144	22	those	those	DT
cord-000248-zueoyesj	144	23	in	in	IN
cord-000248-zueoyesj	144	24	prostate	prostate	NN
cord-000248-zueoyesj	144	25	cancer	cancer	NN
cord-000248-zueoyesj	144	26	:	:	:
cord-000248-zueoyesj	145	1	KLK3	KLK3	NNP
cord-000248-zueoyesj	145	2	/	/	SYM
cord-000248-zueoyesj	145	3	PSA	PSA	NNP
cord-000248-zueoyesj	145	4	(	(	-LRB-
cord-000248-zueoyesj	145	5	Prostate	Prostate	NNP
cord-000248-zueoyesj	145	6	Specific	Specific	NNP
cord-000248-zueoyesj	145	7	Antigen	Antigen	NNP
cord-000248-zueoyesj	145	8	)	)	-RRB-
cord-000248-zueoyesj	145	9	and	and	CC
cord-000248-zueoyesj	145	10	FOS	FOS	NNP
cord-000248-zueoyesj	145	11	.	.	.
cord-000248-zueoyesj	146	1	The	the	DT
cord-000248-zueoyesj	146	2	interpretation	interpretation	NN
cord-000248-zueoyesj	146	3	of	of	IN
cord-000248-zueoyesj	146	4	these	these	DT
cord-000248-zueoyesj	146	5	scatter	scatter	NN
cord-000248-zueoyesj	146	6	plots	plot	NNS
cord-000248-zueoyesj	146	7	is	be	VBZ
cord-000248-zueoyesj	146	8	not	not	RB
cord-000248-zueoyesj	146	9	immediate	immediate	JJ
cord-000248-zueoyesj	146	10	and	and	CC
cord-000248-zueoyesj	146	11	needs	need	VBZ
cord-000248-zueoyesj	146	12	an	an	DT
cord-000248-zueoyesj	146	13	introductory	introductory	JJ
cord-000248-zueoyesj	146	14	explanation	explanation	NN
cord-000248-zueoyesj	146	15	.	.	.
cord-000248-zueoyesj	147	1	Each	each	DT
cord-000248-zueoyesj	147	2	dot	dot	NN
cord-000248-zueoyesj	147	3	corresponds	correspond	VBZ
cord-000248-zueoyesj	147	4	to	to	IN
cord-000248-zueoyesj	147	5	one	one	CD
cord-000248-zueoyesj	147	6	probe	probe	NN
cord-000248-zueoyesj	147	7	of	of	IN
cord-000248-zueoyesj	147	8	the	the	DT
cord-000248-zueoyesj	147	9	array	array	NN
cord-000248-zueoyesj	147	10	.	.	.
cord-000248-zueoyesj	148	1	For	for	IN
cord-000248-zueoyesj	148	2	example	example	NN
cord-000248-zueoyesj	148	3	,	,	,
cord-000248-zueoyesj	148	4	a	a	DT
cord-000248-zueoyesj	148	5	dot	dot	NN
cord-000248-zueoyesj	148	6	that	that	WDT
cord-000248-zueoyesj	148	7	is	be	VBZ
cord-000248-zueoyesj	148	8	very	very	RB
cord-000248-zueoyesj	148	9	close	close	JJ
cord-000248-zueoyesj	148	10	to	to	IN
cord-000248-zueoyesj	148	11	the	the	DT
cord-000248-zueoyesj	148	12	origin	origin	NN
cord-000248-zueoyesj	148	13	of	of	IN
cord-000248-zueoyesj	148	14	coordinates	coordinate	NNS
cord-000248-zueoyesj	148	15	(	(	-LRB-
cord-000248-zueoyesj	148	16	0,0	0,0	NFP
cord-000248-zueoyesj	148	17	)	)	-RRB-
cord-000248-zueoyesj	148	18	indicates	indicate	VBZ
cord-000248-zueoyesj	148	19	a	a	DT
cord-000248-zueoyesj	148	20	probe	probe	NN
cord-000248-zueoyesj	148	21	such	such	JJ
cord-000248-zueoyesj	148	22	that	that	IN
cord-000248-zueoyesj	148	23	its	-PRON-	PRP$
cord-000248-zueoyesj	148	24	pattern	pattern	NN
cord-000248-zueoyesj	148	25	of	of	IN
cord-000248-zueoyesj	148	26	gene	gene	NN
cord-000248-zueoyesj	148	27	expression	expression	NN
cord-000248-zueoyesj	148	28	(	(	-LRB-
cord-000248-zueoyesj	148	29	across	across	IN
cord-000248-zueoyesj	148	30	all	all	DT
cord-000248-zueoyesj	148	31	samples	sample	NNS
cord-000248-zueoyesj	148	32	)	)	-RRB-
cord-000248-zueoyesj	148	33	is	be	VBZ
cord-000248-zueoyesj	148	34	not	not	RB
cord-000248-zueoyesj	148	35	correlated	correlate	VBN
cord-000248-zueoyesj	148	36	with	with	IN
cord-000248-zueoyesj	148	37	the	the	DT
cord-000248-zueoyesj	148	38	Jensen	Jensen	NNP
cord-000248-zueoyesj	148	39	-	-	HYPH
cord-000248-zueoyesj	148	40	Shannon	Shannon	NNP
cord-000248-zueoyesj	148	41	divergence	divergence	NN
cord-000248-zueoyesj	148	42	to	to	IN
cord-000248-zueoyesj	148	43	the	the	DT
cord-000248-zueoyesj	148	44	average	average	JJ
cord-000248-zueoyesj	148	45	profile	profile	NN
cord-000248-zueoyesj	148	46	of	of	IN
cord-000248-zueoyesj	148	47	a	a	DT
cord-000248-zueoyesj	148	48	metastasis	metastasis	NN
cord-000248-zueoyesj	148	49	pattern	pattern	NN
cord-000248-zueoyesj	148	50	.	.	.
cord-000248-zueoyesj	149	1	It	-PRON-	PRP
cord-000248-zueoyesj	149	2	is	be	VBZ
cord-000248-zueoyesj	149	3	,	,	,
cord-000248-zueoyesj	149	4	in	in	IN
cord-000248-zueoyesj	149	5	essence	essence	NN
cord-000248-zueoyesj	149	6	,	,	,
cord-000248-zueoyesj	149	7	a	a	DT
cord-000248-zueoyesj	149	8	probe	probe	NN
cord-000248-zueoyesj	149	9	which	which	WDT
cord-000248-zueoyesj	149	10	is	be	VBZ
cord-000248-zueoyesj	149	11	highly	highly	RB
cord-000248-zueoyesj	149	12	uninteresting	uninteresting	JJ
cord-000248-zueoyesj	149	13	in	in	IN
cord-000248-zueoyesj	149	14	this	this	DT
cord-000248-zueoyesj	149	15	regard	regard	NN
cord-000248-zueoyesj	149	16	.	.	.
cord-000248-zueoyesj	150	1	Probes	probe	NNS
cord-000248-zueoyesj	150	2	that	that	WDT
cord-000248-zueoyesj	150	3	have	have	VBP
cord-000248-zueoyesj	150	4	a	a	DT
cord-000248-zueoyesj	150	5	high	high	JJ
cord-000248-zueoyesj	150	6	correlation	correlation	NN
cord-000248-zueoyesj	150	7	,	,	,
cord-000248-zueoyesj	150	8	across	across	IN
cord-000248-zueoyesj	150	9	all	all	DT
cord-000248-zueoyesj	150	10	samples	sample	NNS
cord-000248-zueoyesj	150	11	,	,	,
cord-000248-zueoyesj	150	12	either	either	CC
cord-000248-zueoyesj	150	13	positive	positive	JJ
cord-000248-zueoyesj	150	14	or	or	CC
cord-000248-zueoyesj	150	15	negative	negative	JJ
cord-000248-zueoyesj	150	16	with	with	IN
cord-000248-zueoyesj	150	17	the	the	DT
cord-000248-zueoyesj	150	18	Jensen	Jensen	NNP
cord-000248-zueoyesj	150	19	-	-	HYPH
cord-000248-zueoyesj	150	20	Shannon	Shannon	NNP
cord-000248-zueoyesj	150	21	divergence	divergence	NN
cord-000248-zueoyesj	150	22	to	to	IN
cord-000248-zueoyesj	150	23	the	the	DT
cord-000248-zueoyesj	150	24	average	average	JJ
cord-000248-zueoyesj	150	25	profile	profile	NN
cord-000248-zueoyesj	150	26	of	of	IN
cord-000248-zueoyesj	150	27	a	a	DT
cord-000248-zueoyesj	150	28	metastasis	metastasis	NN
cord-000248-zueoyesj	150	29	pattern	pattern	NN
cord-000248-zueoyesj	150	30	are	be	VBP
cord-000248-zueoyesj	150	31	highly	highly	RB
cord-000248-zueoyesj	150	32	informative	informative	JJ
cord-000248-zueoyesj	150	33	.	.	.
cord-000248-zueoyesj	151	1	They	-PRON-	PRP
cord-000248-zueoyesj	151	2	'	'	VBD
cord-000248-zueoyesj	151	3	'	'	``
cord-000248-zueoyesj	151	4	co	co	JJ
cord-000248-zueoyesj	151	5	-	-	VB
cord-000248-zueoyesj	151	6	express	express	JJ
cord-000248-zueoyesj	151	7	'	'	''
cord-000248-zueoyesj	151	8	'	'	''
cord-000248-zueoyesj	151	9	with	with	IN
cord-000248-zueoyesj	151	10	this	this	DT
cord-000248-zueoyesj	151	11	measure	measure	NN
cord-000248-zueoyesj	151	12	.	.	.
cord-000248-zueoyesj	152	1	Although	although	IN
cord-000248-zueoyesj	152	2	we	-PRON-	PRP
cord-000248-zueoyesj	152	3	provide	provide	VBP
cord-000248-zueoyesj	152	4	in	in	IN
cord-000248-zueoyesj	152	5	the	the	DT
cord-000248-zueoyesj	152	6	supplementary	supplementary	JJ
cord-000248-zueoyesj	152	7	material	material	NN
cord-000248-zueoyesj	152	8	the	the	DT
cord-000248-zueoyesj	152	9	information	information	NN
cord-000248-zueoyesj	152	10	corresponding	correspond	VBG
cord-000248-zueoyesj	152	11	to	to	IN
cord-000248-zueoyesj	152	12	all	all	DT
cord-000248-zueoyesj	152	13	probes	probe	NNS
cord-000248-zueoyesj	152	14	,	,	,
cord-000248-zueoyesj	152	15	we	-PRON-	PRP
cord-000248-zueoyesj	152	16	will	will	MD
cord-000248-zueoyesj	152	17	discuss	discuss	VB
cord-000248-zueoyesj	152	18	just	just	RB
cord-000248-zueoyesj	152	19	a	a	DT
cord-000248-zueoyesj	152	20	few	few	JJ
cord-000248-zueoyesj	152	21	of	of	IN
cord-000248-zueoyesj	152	22	them	-PRON-	PRP
cord-000248-zueoyesj	152	23	.	.	.
cord-000248-zueoyesj	153	1	This	this	DT
cord-000248-zueoyesj	153	2	will	will	MD
cord-000248-zueoyesj	153	3	allow	allow	VB
cord-000248-zueoyesj	153	4	the	the	DT
cord-000248-zueoyesj	153	5	reader	reader	NN
cord-000248-zueoyesj	153	6	to	to	TO
cord-000248-zueoyesj	153	7	understand	understand	VB
cord-000248-zueoyesj	153	8	these	these	DT
cord-000248-zueoyesj	153	9	plots	plot	NNS
cord-000248-zueoyesj	153	10	and	and	CC
cord-000248-zueoyesj	153	11	will	will	MD
cord-000248-zueoyesj	153	12	put	put	VB
cord-000248-zueoyesj	153	13	our	-PRON-	PRP$
cord-000248-zueoyesj	153	14	results	result	NNS
cord-000248-zueoyesj	153	15	in	in	IN
cord-000248-zueoyesj	153	16	the	the	DT
cord-000248-zueoyesj	153	17	perspective	perspective	NN
cord-000248-zueoyesj	153	18	with	with	IN
cord-000248-zueoyesj	153	19	current	current	JJ
cord-000248-zueoyesj	153	20	research	research	NN
cord-000248-zueoyesj	153	21	in	in	IN
cord-000248-zueoyesj	153	22	prostate	prostate	NN
cord-000248-zueoyesj	153	23	cancer	cancer	NN
cord-000248-zueoyesj	153	24	.	.	.
cord-000248-zueoyesj	154	1	We	-PRON-	PRP
cord-000248-zueoyesj	154	2	particularly	particularly	RB
cord-000248-zueoyesj	154	3	highlight	highlight	VBP
cord-000248-zueoyesj	154	4	the	the	DT
cord-000248-zueoyesj	154	5	position	position	NN
cord-000248-zueoyesj	154	6	of	of	IN
cord-000248-zueoyesj	154	7	KLK3/	KLK3/	NNP
cord-000248-zueoyesj	154	8	PSA	PSA	NNP
cord-000248-zueoyesj	154	9	,	,	,
cord-000248-zueoyesj	154	10	FOS	FOS	NNP
cord-000248-zueoyesj	154	11	and	and	CC
cord-000248-zueoyesj	154	12	CCL2	CCL2	NNP
cord-000248-zueoyesj	154	13	.	.	.
cord-000248-zueoyesj	155	1	To	to	IN
cord-000248-zueoyesj	155	2	our	-PRON-	PRP$
cord-000248-zueoyesj	155	3	surprise	surprise	NN
cord-000248-zueoyesj	155	4	,	,	,
cord-000248-zueoyesj	155	5	we	-PRON-	PRP
cord-000248-zueoyesj	155	6	have	have	VBP
cord-000248-zueoyesj	155	7	found	find	VBN
cord-000248-zueoyesj	155	8	which	which	WDT
cord-000248-zueoyesj	155	9	is	be	VBZ
cord-000248-zueoyesj	155	10	perhaps	perhaps	RB
cord-000248-zueoyesj	155	11	the	the	DT
cord-000248-zueoyesj	155	12	most	most	RBS
cord-000248-zueoyesj	155	13	famous	famous	JJ
cord-000248-zueoyesj	155	14	biomarker	biomarker	NN
cord-000248-zueoyesj	155	15	in	in	IN
cord-000248-zueoyesj	155	16	prostate	prostate	NN
cord-000248-zueoyesj	155	17	cancer	cancer	NN
cord-000248-zueoyesj	155	18	KLK3/	KLK3/	NNP
cord-000248-zueoyesj	155	19	PSA	PSA	NNP
cord-000248-zueoyesj	155	20	(	(	-LRB-
cord-000248-zueoyesj	155	21	Kallikrein	Kallikrein	NNP
cord-000248-zueoyesj	155	22	-	-	HYPH
cord-000248-zueoyesj	155	23	related	relate	VBN
cord-000248-zueoyesj	155	24	peptidase	peptidase	NN
cord-000248-zueoyesj	155	25	3	3	CD
cord-000248-zueoyesj	155	26	)	)	-RRB-
cord-000248-zueoyesj	155	27	,	,	,
cord-000248-zueoyesj	155	28	probe	probe	NN
cord-000248-zueoyesj	155	29	G_914588	G_914588	NNP
cord-000248-zueoyesj	155	30	(	(	-LRB-
cord-000248-zueoyesj	155	31	correlations	correlation	NNS
cord-000248-zueoyesj	155	32	of	of	IN
cord-000248-zueoyesj	155	33	20.9312	20.9312	CD
cord-000248-zueoyesj	155	34	and	and	CC
cord-000248-zueoyesj	155	35	20.9000	20.9000	CD
cord-000248-zueoyesj	155	36	respectively	respectively	RB
cord-000248-zueoyesj	155	37	)	)	-RRB-
cord-000248-zueoyesj	155	38	.	.	.
cord-000248-zueoyesj	156	1	FOS	FOS	NNP
cord-000248-zueoyesj	156	2	and	and	CC
cord-000248-zueoyesj	156	3	KLK3/	KLK3/	NNP
cord-000248-zueoyesj	156	4	PSA	PSA	NNP
cord-000248-zueoyesj	156	5	are	be	VBP
cord-000248-zueoyesj	156	6	the	the	DT
cord-000248-zueoyesj	156	7	second	second	JJ
cord-000248-zueoyesj	156	8	and	and	CC
cord-000248-zueoyesj	156	9	the	the	DT
cord-000248-zueoyesj	156	10	fourth	fourth	JJ
cord-000248-zueoyesj	156	11	most	most	RBS
cord-000248-zueoyesj	156	12	negatively	negatively	RB
cord-000248-zueoyesj	156	13	correlated	correlate	VBN
cord-000248-zueoyesj	156	14	probes	probe	NNS
cord-000248-zueoyesj	156	15	in	in	IN
cord-000248-zueoyesj	156	16	this	this	DT
cord-000248-zueoyesj	156	17	ranking	ranking	NN
cord-000248-zueoyesj	156	18	of	of	IN
cord-000248-zueoyesj	156	19	all	all	PDT
cord-000248-zueoyesj	156	20	the	the	DT
cord-000248-zueoyesj	156	21	genes	gene	NNS
cord-000248-zueoyesj	156	22	in	in	IN
cord-000248-zueoyesj	156	23	the	the	DT
cord-000248-zueoyesj	156	24	microarray	microarray	NN
cord-000248-zueoyesj	156	25	.	.	.
cord-000248-zueoyesj	157	1	With	with	IN
cord-000248-zueoyesj	157	2	opposite	opposite	JJ
cord-000248-zueoyesj	157	3	signs	sign	NNS
cord-000248-zueoyesj	157	4	for	for	IN
cord-000248-zueoyesj	157	5	correlations	correlation	NNS
cord-000248-zueoyesj	157	6	are	be	VBP
cord-000248-zueoyesj	157	7	CDKN2D	cdkn2d	NN
cord-000248-zueoyesj	157	8	,	,	,
cord-000248-zueoyesj	157	9	FOXM1	FOXM1	NNP
cord-000248-zueoyesj	157	10	,	,	,
cord-000248-zueoyesj	157	11	and	and	CC
cord-000248-zueoyesj	157	12	BRCA2	brca2	NN
cord-000248-zueoyesj	157	13	.	.	.
cord-000248-zueoyesj	158	1	The	the	DT
cord-000248-zueoyesj	158	2	following	follow	VBG
cord-000248-zueoyesj	158	3	is	be	VBZ
cord-000248-zueoyesj	158	4	a	a	DT
cord-000248-zueoyesj	158	5	discussion	discussion	NN
cord-000248-zueoyesj	158	6	of	of	IN
cord-000248-zueoyesj	158	7	a	a	DT
cord-000248-zueoyesj	158	8	selection	selection	NN
cord-000248-zueoyesj	158	9	of	of	IN
cord-000248-zueoyesj	158	10	probes	probe	NNS
cord-000248-zueoyesj	158	11	(	(	-LRB-
cord-000248-zueoyesj	158	12	highlighted	highlight	VBN
cord-000248-zueoyesj	158	13	in	in	IN
cord-000248-zueoyesj	158	14	Figure	Figure	NNP
cord-000248-zueoyesj	158	15	3	3	CD
cord-000248-zueoyesj	158	16	)	)	-RRB-
cord-000248-zueoyesj	158	17	in	in	IN
cord-000248-zueoyesj	158	18	the	the	DT
cord-000248-zueoyesj	158	19	context	context	NN
cord-000248-zueoyesj	158	20	of	of	IN
cord-000248-zueoyesj	158	21	prostate	prostate	NN
cord-000248-zueoyesj	158	22	cancer	cancer	NN
cord-000248-zueoyesj	158	23	.	.	.
cord-000248-zueoyesj	159	1	CDKN2D	cdkn2d	NN
cord-000248-zueoyesj	160	1	(	(	-LRB-
cord-000248-zueoyesj	160	2	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	160	3	-	-	HYPH
cord-000248-zueoyesj	160	4	dependent	dependent	JJ
cord-000248-zueoyesj	160	5	kinase	kinase	NN
cord-000248-zueoyesj	160	6	inhibitor	inhibitor	NN
cord-000248-zueoyesj	160	7	2D	2d	NN
cord-000248-zueoyesj	160	8	,	,	,
cord-000248-zueoyesj	160	9	p19	p19	NN
cord-000248-zueoyesj	160	10	,	,	,
cord-000248-zueoyesj	160	11	inhibits	inhibit	VBZ
cord-000248-zueoyesj	160	12	CDK4	CDK4	NNP
cord-000248-zueoyesj	160	13	)	)	-RRB-
cord-000248-zueoyesj	160	14	.	.	.
cord-000248-zueoyesj	161	1	One	one	CD
cord-000248-zueoyesj	161	2	of	of	IN
cord-000248-zueoyesj	161	3	the	the	DT
cord-000248-zueoyesj	161	4	genes	gene	NNS
cord-000248-zueoyesj	161	5	that	that	WDT
cord-000248-zueoyesj	161	6	has	have	VBZ
cord-000248-zueoyesj	161	7	strong	strong	JJ
cord-000248-zueoyesj	161	8	positive	positive	JJ
cord-000248-zueoyesj	161	9	correlations	correlation	NNS
cord-000248-zueoyesj	161	10	is	be	VBZ
cord-000248-zueoyesj	161	11	CDKN2D	cdkn2d	NN
cord-000248-zueoyesj	161	12	,	,	,
cord-000248-zueoyesj	162	1	(	(	-LRB-
cord-000248-zueoyesj	162	2	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	162	3	-	-	HYPH
cord-000248-zueoyesj	162	4	dependent	dependent	JJ
cord-000248-zueoyesj	162	5	kinase	kinase	NN
cord-000248-zueoyesj	162	6	inhibitor	inhibitor	NN
cord-000248-zueoyesj	162	7	2D	2d	NN
cord-000248-zueoyesj	162	8	,	,	,
cord-000248-zueoyesj	162	9	p19	p19	NN
cord-000248-zueoyesj	162	10	,	,	,
cord-000248-zueoyesj	162	11	inhibits	inhibit	VBZ
cord-000248-zueoyesj	162	12	CDK4	CDK4	NNP
cord-000248-zueoyesj	162	13	)	)	-RRB-
cord-000248-zueoyesj	163	1	(	(	-LRB-
cord-000248-zueoyesj	163	2	Pearson	Pearson	NNP
cord-000248-zueoyesj	163	3	correlation	correlation	NN
cord-000248-zueoyesj	163	4	of	of	IN
cord-000248-zueoyesj	163	5	0.7543	0.7543	CD
cord-000248-zueoyesj	163	6	,	,	,
cord-000248-zueoyesj	163	7	Spearman	Spearman	NNP
cord-000248-zueoyesj	163	8	correlation	correlation	NN
cord-000248-zueoyesj	163	9	0.6833	0.6833	CD
cord-000248-zueoyesj	163	10	)	)	-RRB-
cord-000248-zueoyesj	163	11	,	,	,
cord-000248-zueoyesj	163	12	probe	probe	VBP
cord-000248-zueoyesj	163	13	G_145503	G_145503	NNP
cord-000248-zueoyesj	163	14	.	.	.
cord-000248-zueoyesj	164	1	A	a	DT
cord-000248-zueoyesj	164	2	gene	gene	NN
cord-000248-zueoyesj	164	3	that	that	WDT
cord-000248-zueoyesj	164	4	shows	show	VBZ
cord-000248-zueoyesj	164	5	a	a	DT
cord-000248-zueoyesj	164	6	positive	positive	JJ
cord-000248-zueoyesj	164	7	correlation	correlation	NN
cord-000248-zueoyesj	164	8	with	with	IN
cord-000248-zueoyesj	164	9	the	the	DT
cord-000248-zueoyesj	164	10	divergence	divergence	NN
cord-000248-zueoyesj	164	11	of	of	IN
cord-000248-zueoyesj	164	12	a	a	DT
cord-000248-zueoyesj	164	13	metastasis	metastasis	NN
cord-000248-zueoyesj	164	14	profile	profile	NN
cord-000248-zueoyesj	164	15	indicates	indicate	VBZ
cord-000248-zueoyesj	164	16	a	a	DT
cord-000248-zueoyesj	164	17	gene	gene	NN
cord-000248-zueoyesj	164	18	that	that	WDT
cord-000248-zueoyesj	164	19	has	have	VBZ
cord-000248-zueoyesj	164	20	a	a	DT
cord-000248-zueoyesj	164	21	putative	putative	JJ
cord-000248-zueoyesj	164	22	reduced	reduce	VBN
cord-000248-zueoyesj	164	23	expression	expression	NN
cord-000248-zueoyesj	164	24	on	on	IN
cord-000248-zueoyesj	164	25	these	these	DT
cord-000248-zueoyesj	164	26	samples	sample	NNS
cord-000248-zueoyesj	164	27	.	.	.
cord-000248-zueoyesj	165	1	CDKN2D	cdkn2d	NN
cord-000248-zueoyesj	165	2	is	be	VBZ
cord-000248-zueoyesj	165	3	a	a	DT
cord-000248-zueoyesj	165	4	known	know	VBN
cord-000248-zueoyesj	165	5	regulator	regulator	NN
cord-000248-zueoyesj	165	6	of	of	IN
cord-000248-zueoyesj	165	7	cell	cell	NN
cord-000248-zueoyesj	165	8	growth	growth	NN
cord-000248-zueoyesj	165	9	regulator	regulator	NN
cord-000248-zueoyesj	165	10	and	and	CC
cord-000248-zueoyesj	165	11	controls	control	VBZ
cord-000248-zueoyesj	165	12	cell	cell	NN
cord-000248-zueoyesj	165	13	cycle	cycle	NN
cord-000248-zueoyesj	165	14	G1	G1	NNP
cord-000248-zueoyesj	165	15	progression	progression	NN
cord-000248-zueoyesj	165	16	[	[	-LRB-
cord-000248-zueoyesj	165	17	46	46	CD
cord-000248-zueoyesj	165	18	,	,	,
cord-000248-zueoyesj	165	19	47	47	CD
cord-000248-zueoyesj	165	20	]	]	-RRB-
cord-000248-zueoyesj	165	21	.	.	.
cord-000248-zueoyesj	166	1	Loss	loss	NN
cord-000248-zueoyesj	166	2	of	of	IN
cord-000248-zueoyesj	166	3	CDKN2D	cdkn2d	NN
cord-000248-zueoyesj	166	4	in	in	IN
cord-000248-zueoyesj	166	5	cancer	cancer	NN
cord-000248-zueoyesj	166	6	cells	cell	NNS
cord-000248-zueoyesj	166	7	is	be	VBZ
cord-000248-zueoyesj	166	8	one	one	CD
cord-000248-zueoyesj	166	9	event	event	NN
cord-000248-zueoyesj	166	10	which	which	WDT
cord-000248-zueoyesj	166	11	is	be	VBZ
cord-000248-zueoyesj	166	12	generally	generally	RB
cord-000248-zueoyesj	166	13	associated	associate	VBN
cord-000248-zueoyesj	166	14	to	to	IN
cord-000248-zueoyesj	166	15	a	a	DT
cord-000248-zueoyesj	166	16	more	more	RBR
cord-000248-zueoyesj	166	17	malignant	malignant	JJ
cord-000248-zueoyesj	166	18	phenotype	phenotype	NN
cord-000248-zueoyesj	166	19	.	.	.
cord-000248-zueoyesj	167	1	FOXM1	foxm1	UH
cord-000248-zueoyesj	167	2	.	.	.
cord-000248-zueoyesj	168	1	Another	another	DT
cord-000248-zueoyesj	168	2	probe	probe	NN
cord-000248-zueoyesj	168	3	that	that	WDT
cord-000248-zueoyesj	168	4	presents	present	VBZ
cord-000248-zueoyesj	168	5	positive	positive	JJ
cord-000248-zueoyesj	168	6	correlations	correlation	NNS
cord-000248-zueoyesj	168	7	is	be	VBZ
cord-000248-zueoyesj	168	8	FOXM1	foxm1	XX
cord-000248-zueoyesj	169	1	(	(	-LRB-
cord-000248-zueoyesj	169	2	Forkhead	Forkhead	NNP
cord-000248-zueoyesj	169	3	box	box	NN
cord-000248-zueoyesj	169	4	M1	M1	NNP
cord-000248-zueoyesj	169	5	)	)	-RRB-
cord-000248-zueoyesj	169	6	,	,	,
cord-000248-zueoyesj	169	7	with	with	IN
cord-000248-zueoyesj	169	8	Pearson	Pearson	NNP
cord-000248-zueoyesj	169	9	correlation	correlation	NN
cord-000248-zueoyesj	169	10	of	of	IN
cord-000248-zueoyesj	169	11	0.7039	0.7039	CD
cord-000248-zueoyesj	169	12	and	and	CC
cord-000248-zueoyesj	169	13	Spearman	Spearman	NNP
cord-000248-zueoyesj	169	14	correlation	correlation	NN
cord-000248-zueoyesj	169	15	0.7500	0.7500	CD
cord-000248-zueoyesj	169	16	)	)	-RRB-
cord-000248-zueoyesj	169	17	,	,	,
cord-000248-zueoyesj	169	18	probe	probe	VBP
cord-000248-zueoyesj	169	19	G_564803	G_564803	NNP
cord-000248-zueoyesj	169	20	.	.	.
cord-000248-zueoyesj	170	1	It	-PRON-	PRP
cord-000248-zueoyesj	170	2	has	have	VBZ
cord-000248-zueoyesj	170	3	been	be	VBN
cord-000248-zueoyesj	170	4	recently	recently	RB
cord-000248-zueoyesj	170	5	shown	show	VBN
cord-000248-zueoyesj	170	6	that	that	IN
cord-000248-zueoyesj	170	7	the	the	DT
cord-000248-zueoyesj	170	8	depletion	depletion	NN
cord-000248-zueoyesj	170	9	of	of	IN
cord-000248-zueoyesj	170	10	FOXM1	foxm1	NN
cord-000248-zueoyesj	170	11	still	still	RB
cord-000248-zueoyesj	170	12	allows	allow	VBZ
cord-000248-zueoyesj	170	13	cells	cell	NNS
cord-000248-zueoyesj	170	14	to	to	TO
cord-000248-zueoyesj	170	15	enter	enter	VB
cord-000248-zueoyesj	170	16	mitosis	mitosis	NN
cord-000248-zueoyesj	170	17	but	but	CC
cord-000248-zueoyesj	170	18	they	-PRON-	PRP
cord-000248-zueoyesj	170	19	are	be	VBP
cord-000248-zueoyesj	170	20	unable	unable	JJ
cord-000248-zueoyesj	170	21	to	to	TO
cord-000248-zueoyesj	170	22	complete	complete	VB
cord-000248-zueoyesj	170	23	cell	cell	NN
cord-000248-zueoyesj	170	24	division	division	NN
cord-000248-zueoyesj	170	25	.	.	.
cord-000248-zueoyesj	171	1	As	as	IN
cord-000248-zueoyesj	171	2	a	a	DT
cord-000248-zueoyesj	171	3	consequence	consequence	NN
cord-000248-zueoyesj	171	4	this	this	DT
cord-000248-zueoyesj	171	5	leads	lead	VBZ
cord-000248-zueoyesj	171	6	to	to	IN
cord-000248-zueoyesj	171	7	mitotic	mitotic	JJ
cord-000248-zueoyesj	171	8	catastrophe	catastrophe	NN
cord-000248-zueoyesj	171	9	or	or	CC
cord-000248-zueoyesj	171	10	endoreduplication	endoreduplication	NN
cord-000248-zueoyesj	171	11	[	[	-LRB-
cord-000248-zueoyesj	171	12	48	48	CD
cord-000248-zueoyesj	171	13	]	]	-RRB-
cord-000248-zueoyesj	171	14	.	.	.
cord-000248-zueoyesj	172	1	FOXM1	FOXM1	NNP
cord-000248-zueoyesj	172	2	is	be	VBZ
cord-000248-zueoyesj	172	3	considered	consider	VBN
cord-000248-zueoyesj	172	4	a	a	DT
cord-000248-zueoyesj	172	5	key	key	JJ
cord-000248-zueoyesj	172	6	regulator	regulator	NN
cord-000248-zueoyesj	172	7	of	of	IN
cord-000248-zueoyesj	172	8	a	a	DT
cord-000248-zueoyesj	172	9	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	172	10	cluster	cluster	NN
cord-000248-zueoyesj	172	11	which	which	WDT
cord-000248-zueoyesj	172	12	is	be	VBZ
cord-000248-zueoyesj	172	13	that	that	DT
cord-000248-zueoyesj	172	14	is	be	VBZ
cord-000248-zueoyesj	172	15	essential	essential	JJ
cord-000248-zueoyesj	172	16	for	for	IN
cord-000248-zueoyesj	172	17	proper	proper	JJ
cord-000248-zueoyesj	172	18	execution	execution	NN
cord-000248-zueoyesj	172	19	of	of	IN
cord-000248-zueoyesj	172	20	the	the	DT
cord-000248-zueoyesj	172	21	mitotic	mitotic	JJ
cord-000248-zueoyesj	172	22	program	program	NN
cord-000248-zueoyesj	172	23	and	and	CC
cord-000248-zueoyesj	172	24	the	the	DT
cord-000248-zueoyesj	172	25	control	control	NN
cord-000248-zueoyesj	172	26	of	of	IN
cord-000248-zueoyesj	172	27	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	172	28	stability	stability	NN
cord-000248-zueoyesj	172	29	[	[	-LRB-
cord-000248-zueoyesj	172	30	49	49	CD
cord-000248-zueoyesj	172	31	]	]	-RRB-
cord-000248-zueoyesj	172	32	.	.	.
cord-000248-zueoyesj	173	1	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	174	1	-(Breast	-(Breast	NNP
cord-000248-zueoyesj	175	1	cancer	cancer	NN
cord-000248-zueoyesj	175	2	2	2	CD
cord-000248-zueoyesj	175	3	,	,	,
cord-000248-zueoyesj	175	4	early	early	JJ
cord-000248-zueoyesj	175	5	onset	onset	NN
cord-000248-zueoyesj	175	6	)	)	-RRB-
cord-000248-zueoyesj	175	7	.	.	.
cord-000248-zueoyesj	176	1	Another	another	DT
cord-000248-zueoyesj	176	2	gene	gene	NN
cord-000248-zueoyesj	176	3	with	with	IN
cord-000248-zueoyesj	176	4	positive	positive	JJ
cord-000248-zueoyesj	176	5	correlations	correlation	NNS
cord-000248-zueoyesj	176	6	is	be	VBZ
cord-000248-zueoyesj	176	7	BRCA2	brca2	XX
cord-000248-zueoyesj	177	1	(	(	-LRB-
cord-000248-zueoyesj	177	2	Breast	breast	NN
cord-000248-zueoyesj	177	3	cancer	cancer	NN
cord-000248-zueoyesj	177	4	2	2	CD
cord-000248-zueoyesj	177	5	,	,	,
cord-000248-zueoyesj	177	6	early	early	JJ
cord-000248-zueoyesj	177	7	onset	onset	NN
cord-000248-zueoyesj	177	8	)	)	-RRB-
cord-000248-zueoyesj	177	9	,	,	,
cord-000248-zueoyesj	177	10	probe	probe	NN
cord-000248-zueoyesj	177	11	G_193736	G_193736	NNP
cord-000248-zueoyesj	177	12	,	,	,
cord-000248-zueoyesj	177	13	with	with	IN
cord-000248-zueoyesj	177	14	Pearson	Pearson	NNP
cord-000248-zueoyesj	177	15	correlation	correlation	NN
cord-000248-zueoyesj	177	16	of	of	IN
cord-000248-zueoyesj	177	17	0.8161	0.8161	CD
cord-000248-zueoyesj	177	18	and	and	CC
cord-000248-zueoyesj	177	19	Spearman	Spearman	NNP
cord-000248-zueoyesj	177	20	correlation	correlation	NN
cord-000248-zueoyesj	177	21	0.7333	0.7333	CD
cord-000248-zueoyesj	177	22	)	)	-RRB-
cord-000248-zueoyesj	177	23	.	.	.
cord-000248-zueoyesj	178	1	While	while	IN
cord-000248-zueoyesj	178	2	the	the	DT
cord-000248-zueoyesj	178	3	loss	loss	NN
cord-000248-zueoyesj	178	4	of	of	IN
cord-000248-zueoyesj	178	5	BRCA2	brca2	NN
cord-000248-zueoyesj	178	6	function	function	NN
cord-000248-zueoyesj	178	7	and	and	CC
cord-000248-zueoyesj	178	8	its	-PRON-	PRP$
cord-000248-zueoyesj	178	9	consequences	consequence	NNS
cord-000248-zueoyesj	178	10	in	in	IN
cord-000248-zueoyesj	178	11	prostate	prostate	NN
cord-000248-zueoyesj	178	12	cancer	cancer	NN
cord-000248-zueoyesj	178	13	is	be	VBZ
cord-000248-zueoyesj	178	14	being	be	VBG
cord-000248-zueoyesj	178	15	reconsidered	reconsider	VBN
cord-000248-zueoyesj	178	16	[	[	-LRB-
cord-000248-zueoyesj	178	17	50	50	CD
cord-000248-zueoyesj	178	18	,	,	,
cord-000248-zueoyesj	178	19	51	51	CD
cord-000248-zueoyesj	178	20	,	,	,
cord-000248-zueoyesj	178	21	52	52	CD
cord-000248-zueoyesj	178	22	,	,	,
cord-000248-zueoyesj	178	23	53	53	CD
cord-000248-zueoyesj	178	24	]	]	-RRB-
cord-000248-zueoyesj	178	25	,	,	,
cord-000248-zueoyesj	178	26	BRCA2	brca2	NN
cord-000248-zueoyesj	178	27	is	be	VBZ
cord-000248-zueoyesj	178	28	generally	generally	RB
cord-000248-zueoyesj	178	29	regarded	regard	VBN
cord-000248-zueoyesj	178	30	as	as	IN
cord-000248-zueoyesj	178	31	a	a	DT
cord-000248-zueoyesj	178	32	'	'	''
cord-000248-zueoyesj	178	33	'	'	``
cord-000248-zueoyesj	178	34	tumor	tumor	NN
cord-000248-zueoyesj	178	35	suppressor	suppressor	NN
cord-000248-zueoyesj	178	36	'	'	''
cord-000248-zueoyesj	178	37	'	'	''
cord-000248-zueoyesj	178	38	,	,	,
cord-000248-zueoyesj	178	39	with	with	IN
cord-000248-zueoyesj	178	40	an	an	DT
cord-000248-zueoyesj	178	41	established	establish	VBN
cord-000248-zueoyesj	178	42	role	role	NN
cord-000248-zueoyesj	178	43	in	in	IN
cord-000248-zueoyesj	178	44	maintaining	maintain	VBG
cord-000248-zueoyesj	178	45	genomic	genomic	JJ
cord-000248-zueoyesj	178	46	stability	stability	NN
cord-000248-zueoyesj	178	47	via	via	IN
cord-000248-zueoyesj	178	48	its	-PRON-	PRP$
cord-000248-zueoyesj	178	49	function	function	NN
cord-000248-zueoyesj	178	50	in	in	IN
cord-000248-zueoyesj	178	51	the	the	DT
cord-000248-zueoyesj	178	52	homologous	homologous	JJ
cord-000248-zueoyesj	178	53	recombination	recombination	NN
cord-000248-zueoyesj	178	54	pathway	pathway	NN
cord-000248-zueoyesj	178	55	for	for	IN
cord-000248-zueoyesj	178	56	double	double	JJ
cord-000248-zueoyesj	178	57	-	-	HYPH
cord-000248-zueoyesj	178	58	strand	strand	NN
cord-000248-zueoyesj	178	59	DNA	dna	NN
cord-000248-zueoyesj	178	60	repair	repair	NN
cord-000248-zueoyesj	178	61	.	.	.
cord-000248-zueoyesj	179	1	This	this	DT
cord-000248-zueoyesj	179	2	result	result	NN
cord-000248-zueoyesj	179	3	is	be	VBZ
cord-000248-zueoyesj	179	4	supporting	support	VBG
cord-000248-zueoyesj	179	5	its	-PRON-	PRP$
cord-000248-zueoyesj	179	6	proposed	propose	VBN
cord-000248-zueoyesj	179	7	function	function	NN
cord-000248-zueoyesj	179	8	.	.	.
cord-000248-zueoyesj	180	1	Loss	loss	NN
cord-000248-zueoyesj	180	2	of	of	IN
cord-000248-zueoyesj	180	3	BRCA2	brca2	NN
cord-000248-zueoyesj	180	4	function	function	NN
cord-000248-zueoyesj	180	5	is	be	VBZ
cord-000248-zueoyesj	180	6	thus	thus	RB
cord-000248-zueoyesj	180	7	a	a	DT
cord-000248-zueoyesj	180	8	warning	warning	NN
cord-000248-zueoyesj	180	9	sign	sign	NN
cord-000248-zueoyesj	180	10	of	of	IN
cord-000248-zueoyesj	180	11	the	the	DT
cord-000248-zueoyesj	180	12	existence	existence	NN
cord-000248-zueoyesj	180	13	of	of	IN
cord-000248-zueoyesj	180	14	error	error	NN
cord-000248-zueoyesj	180	15	prone	prone	JJ
cord-000248-zueoyesj	180	16	cell	cell	NN
cord-000248-zueoyesj	180	17	processes	process	NNS
cord-000248-zueoyesj	180	18	.	.	.
cord-000248-zueoyesj	181	1	In	in	IN
cord-000248-zueoyesj	181	2	prostate	prostate	NN
cord-000248-zueoyesj	181	3	cancer	cancer	NN
cord-000248-zueoyesj	181	4	BRCA2	brca2	NN
cord-000248-zueoyesj	181	5	has	have	VBZ
cord-000248-zueoyesj	181	6	been	be	VBN
cord-000248-zueoyesj	181	7	associated	associate	VBN
cord-000248-zueoyesj	181	8	to	to	IN
cord-000248-zueoyesj	181	9	promotion	promotion	NN
cord-000248-zueoyesj	181	10	of	of	IN
cord-000248-zueoyesj	181	11	invasion	invasion	NN
cord-000248-zueoyesj	181	12	through	through	IN
cord-000248-zueoyesj	181	13	upregulation	upregulation	NN
cord-000248-zueoyesj	181	14	of	of	IN
cord-000248-zueoyesj	181	15	MMP9	MMP9	NNP
cord-000248-zueoyesj	181	16	[	[	-LRB-
cord-000248-zueoyesj	181	17	54	54	CD
cord-000248-zueoyesj	181	18	]	]	-RRB-
cord-000248-zueoyesj	181	19	.	.	.
cord-000248-zueoyesj	182	1	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	183	1	loss	loss	NN
cord-000248-zueoyesj	183	2	of	of	IN
cord-000248-zueoyesj	183	3	function	function	NN
cord-000248-zueoyesj	183	4	due	due	IN
cord-000248-zueoyesj	183	5	to	to	IN
cord-000248-zueoyesj	183	6	mutations	mutation	NNS
cord-000248-zueoyesj	183	7	is	be	VBZ
cord-000248-zueoyesj	183	8	linked	link	VBN
cord-000248-zueoyesj	183	9	to	to	IN
cord-000248-zueoyesj	183	10	poor	poor	JJ
cord-000248-zueoyesj	183	11	survival	survival	NN
cord-000248-zueoyesj	183	12	in	in	IN
cord-000248-zueoyesj	183	13	prostate	prostate	NN
cord-000248-zueoyesj	183	14	cancer	cancer	NN
cord-000248-zueoyesj	183	15	[	[	-LRB-
cord-000248-zueoyesj	183	16	55	55	CD
cord-000248-zueoyesj	183	17	]	]	-RRB-
cord-000248-zueoyesj	183	18	and	and	CC
cord-000248-zueoyesj	183	19	rare	rare	JJ
cord-000248-zueoyesj	183	20	germline	germline	NN
cord-000248-zueoyesj	183	21	mutations	mutation	NNS
cord-000248-zueoyesj	183	22	have	have	VBP
cord-000248-zueoyesj	183	23	been	be	VBN
cord-000248-zueoyesj	183	24	associated	associate	VBN
cord-000248-zueoyesj	183	25	with	with	IN
cord-000248-zueoyesj	183	26	early	early	JJ
cord-000248-zueoyesj	183	27	-	-	HYPH
cord-000248-zueoyesj	183	28	onset	onset	NN
cord-000248-zueoyesj	183	29	of	of	IN
cord-000248-zueoyesj	183	30	prostate	prostate	NN
cord-000248-zueoyesj	183	31	cancer	cancer	NN
cord-000248-zueoyesj	183	32	[	[	-LRB-
cord-000248-zueoyesj	183	33	56	56	CD
cord-000248-zueoyesj	183	34	]	]	-RRB-
cord-000248-zueoyesj	183	35	.	.	.
cord-000248-zueoyesj	184	1	CCL2	CCL2	NNP
cord-000248-zueoyesj	184	2	/	/	SYM
cord-000248-zueoyesj	184	3	MCP-1	MCP-1	NNP
cord-000248-zueoyesj	184	4	(	(	-LRB-
cord-000248-zueoyesj	184	5	chemokine	chemokine	NN
cord-000248-zueoyesj	184	6	(	(	-LRB-
cord-000248-zueoyesj	184	7	C	C	NNP
cord-000248-zueoyesj	184	8	-	-	HYPH
cord-000248-zueoyesj	184	9	C	C	NNP
cord-000248-zueoyesj	184	10	motif	motif	NN
cord-000248-zueoyesj	184	11	)	)	-RRB-
cord-000248-zueoyesj	184	12	ligand	ligand	NN
cord-000248-zueoyesj	184	13	2	2	CD
cord-000248-zueoyesj	184	14	)	)	-RRB-
cord-000248-zueoyesj	184	15	.	.	.
cord-000248-zueoyesj	185	1	Bone	bone	NN
cord-000248-zueoyesj	185	2	is	be	VBZ
cord-000248-zueoyesj	185	3	one	one	CD
cord-000248-zueoyesj	185	4	of	of	IN
cord-000248-zueoyesj	185	5	the	the	DT
cord-000248-zueoyesj	185	6	most	most	RBS
cord-000248-zueoyesj	185	7	common	common	JJ
cord-000248-zueoyesj	185	8	sites	site	NNS
cord-000248-zueoyesj	185	9	of	of	IN
cord-000248-zueoyesj	185	10	prostate	prostate	NN
cord-000248-zueoyesj	185	11	cancer	cancer	NN
cord-000248-zueoyesj	185	12	metastasis	metastasis	NN
cord-000248-zueoyesj	185	13	;	;	:
cord-000248-zueoyesj	185	14	close	close	RB
cord-000248-zueoyesj	185	15	to	to	IN
cord-000248-zueoyesj	185	16	85	85	CD
cord-000248-zueoyesj	185	17	%	%	NN
cord-000248-zueoyesj	185	18	of	of	IN
cord-000248-zueoyesj	185	19	men	man	NNS
cord-000248-zueoyesj	185	20	who	who	WP
cord-000248-zueoyesj	185	21	die	die	VBP
cord-000248-zueoyesj	185	22	of	of	IN
cord-000248-zueoyesj	185	23	prostate	prostate	NN
cord-000248-zueoyesj	185	24	cancer	cancer	NN
cord-000248-zueoyesj	185	25	have	have	VBP
cord-000248-zueoyesj	185	26	bone	bone	NN
cord-000248-zueoyesj	185	27	metastasis	metastasis	NN
cord-000248-zueoyesj	185	28	[	[	-LRB-
cord-000248-zueoyesj	185	29	57	57	CD
cord-000248-zueoyesj	185	30	]	]	-RRB-
cord-000248-zueoyesj	185	31	.	.	.
cord-000248-zueoyesj	186	1	The	the	DT
cord-000248-zueoyesj	186	2	successful	successful	JJ
cord-000248-zueoyesj	186	3	metastatic	metastatic	JJ
cord-000248-zueoyesj	186	4	process	process	NN
cord-000248-zueoyesj	186	5	to	to	IN
cord-000248-zueoyesj	186	6	bone	bone	NN
cord-000248-zueoyesj	186	7	follows	follow	VBZ
cord-000248-zueoyesj	186	8	from	from	IN
cord-000248-zueoyesj	186	9	the	the	DT
cord-000248-zueoyesj	186	10	activation	activation	NN
cord-000248-zueoyesj	186	11	of	of	IN
cord-000248-zueoyesj	186	12	osteoclasts	osteoclast	NNS
cord-000248-zueoyesj	186	13	with	with	IN
cord-000248-zueoyesj	186	14	bone	bone	NN
cord-000248-zueoyesj	186	15	resorption	resorption	NN
cord-000248-zueoyesj	186	16	,	,	,
cord-000248-zueoyesj	186	17	which	which	WDT
cord-000248-zueoyesj	186	18	in	in	IN
cord-000248-zueoyesj	186	19	turns	turn	VBZ
cord-000248-zueoyesj	186	20	leads	lead	VBZ
cord-000248-zueoyesj	186	21	to	to	IN
cord-000248-zueoyesj	186	22	the	the	DT
cord-000248-zueoyesj	186	23	release	release	NN
cord-000248-zueoyesj	186	24	of	of	IN
cord-000248-zueoyesj	186	25	different	different	JJ
cord-000248-zueoyesj	186	26	growth	growth	NN
cord-000248-zueoyesj	186	27	factors	factor	NNS
cord-000248-zueoyesj	186	28	from	from	IN
cord-000248-zueoyesj	186	29	the	the	DT
cord-000248-zueoyesj	186	30	bone	bone	NN
cord-000248-zueoyesj	186	31	matrix	matrix	NN
cord-000248-zueoyesj	186	32	[	[	-LRB-
cord-000248-zueoyesj	186	33	58	58	CD
cord-000248-zueoyesj	186	34	]	]	-RRB-
cord-000248-zueoyesj	186	35	.	.	.
cord-000248-zueoyesj	187	1	CCL2	CCL2	NNP
cord-000248-zueoyesj	187	2	has	have	VBZ
cord-000248-zueoyesj	187	3	been	be	VBN
cord-000248-zueoyesj	187	4	previously	previously	RB
cord-000248-zueoyesj	187	5	reported	report	VBN
cord-000248-zueoyesj	187	6	as	as	IN
cord-000248-zueoyesj	187	7	expressed	express	VBN
cord-000248-zueoyesj	187	8	in	in	IN
cord-000248-zueoyesj	187	9	human	human	JJ
cord-000248-zueoyesj	187	10	bone	bone	NN
cord-000248-zueoyesj	187	11	marrow	marrow	NN
cord-000248-zueoyesj	187	12	endothelial	endothelial	JJ
cord-000248-zueoyesj	187	13	cells	cell	NNS
cord-000248-zueoyesj	187	14	;	;	:
cord-000248-zueoyesj	187	15	the	the	DT
cord-000248-zueoyesj	187	16	CCL2	CCL2	NNP
cord-000248-zueoyesj	187	17	stimulation	stimulation	NN
cord-000248-zueoyesj	187	18	promotes	promote	VBZ
cord-000248-zueoyesj	187	19	prostate	prostate	NN
cord-000248-zueoyesj	187	20	cancer	cancer	NN
cord-000248-zueoyesj	187	21	cell	cell	NN
cord-000248-zueoyesj	187	22	migration	migration	NN
cord-000248-zueoyesj	187	23	and	and	CC
cord-000248-zueoyesj	187	24	proliferation	proliferation	NN
cord-000248-zueoyesj	187	25	[	[	-LRB-
cord-000248-zueoyesj	187	26	57	57	CD
cord-000248-zueoyesj	187	27	,	,	,
cord-000248-zueoyesj	187	28	59	59	CD
cord-000248-zueoyesj	187	29	]	]	-RRB-
cord-000248-zueoyesj	187	30	and	and	CC
cord-000248-zueoyesj	187	31	it	-PRON-	PRP
cord-000248-zueoyesj	187	32	has	have	VBZ
cord-000248-zueoyesj	187	33	been	be	VBN
cord-000248-zueoyesj	187	34	proposed	propose	VBN
cord-000248-zueoyesj	187	35	as	as	IN
cord-000248-zueoyesj	187	36	a	a	DT
cord-000248-zueoyesj	187	37	paracrine	paracrine	NN
cord-000248-zueoyesj	187	38	and	and	CC
cord-000248-zueoyesj	187	39	autocrine	autocrine	NN
cord-000248-zueoyesj	187	40	factor	factor	NN
cord-000248-zueoyesj	187	41	for	for	IN
cord-000248-zueoyesj	187	42	invasion	invasion	NN
cord-000248-zueoyesj	187	43	and	and	CC
cord-000248-zueoyesj	187	44	growth	growth	NN
cord-000248-zueoyesj	187	45	of	of	IN
cord-000248-zueoyesj	187	46	prostate	prostate	NN
cord-000248-zueoyesj	187	47	cancer	cancer	NN
cord-000248-zueoyesj	187	48	[	[	-LRB-
cord-000248-zueoyesj	187	49	60	60	CD
cord-000248-zueoyesj	187	50	]	]	-RRB-
cord-000248-zueoyesj	187	51	.	.	.
cord-000248-zueoyesj	188	1	As	as	IN
cord-000248-zueoyesj	188	2	a	a	DT
cord-000248-zueoyesj	188	3	consequence	consequence	NN
cord-000248-zueoyesj	188	4	of	of	IN
cord-000248-zueoyesj	188	5	this	this	DT
cord-000248-zueoyesj	188	6	central	central	JJ
cord-000248-zueoyesj	188	7	role	role	NN
cord-000248-zueoyesj	188	8	in	in	IN
cord-000248-zueoyesj	188	9	the	the	DT
cord-000248-zueoyesj	188	10	tumor	tumor	NN
cord-000248-zueoyesj	188	11	microenvironment	microenvironment	NN
cord-000248-zueoyesj	188	12	,	,	,
cord-000248-zueoyesj	188	13	CCL2	CCL2	NNP
cord-000248-zueoyesj	188	14	is	be	VBZ
cord-000248-zueoyesj	188	15	being	be	VBG
cord-000248-zueoyesj	188	16	the	the	DT
cord-000248-zueoyesj	188	17	object	object	NN
cord-000248-zueoyesj	188	18	of	of	IN
cord-000248-zueoyesj	188	19	several	several	JJ
cord-000248-zueoyesj	188	20	studies	study	NNS
cord-000248-zueoyesj	188	21	and	and	CC
cord-000248-zueoyesj	188	22	is	be	VBZ
cord-000248-zueoyesj	188	23	included	include	VBN
cord-000248-zueoyesj	188	24	in	in	IN
cord-000248-zueoyesj	188	25	the	the	DT
cord-000248-zueoyesj	188	26	list	list	NN
cord-000248-zueoyesj	188	27	of	of	IN
cord-000248-zueoyesj	188	28	potential	potential	JJ
cord-000248-zueoyesj	188	29	targets	target	NNS
cord-000248-zueoyesj	188	30	for	for	IN
cord-000248-zueoyesj	188	31	novel	novel	JJ
cord-000248-zueoyesj	188	32	therapies	therapy	NNS
cord-000248-zueoyesj	188	33	[	[	-LRB-
cord-000248-zueoyesj	188	34	60	60	CD
cord-000248-zueoyesj	188	35	,	,	,
cord-000248-zueoyesj	188	36	61	61	CD
cord-000248-zueoyesj	188	37	,	,	,
cord-000248-zueoyesj	188	38	62	62	CD
cord-000248-zueoyesj	188	39	,	,	,
cord-000248-zueoyesj	188	40	63	63	CD
cord-000248-zueoyesj	188	41	,	,	,
cord-000248-zueoyesj	188	42	64	64	CD
cord-000248-zueoyesj	188	43	,	,	,
cord-000248-zueoyesj	188	44	65	65	CD
cord-000248-zueoyesj	188	45	,	,	,
cord-000248-zueoyesj	188	46	66	66	CD
cord-000248-zueoyesj	188	47	,	,	,
cord-000248-zueoyesj	188	48	67	67	CD
cord-000248-zueoyesj	188	49	,	,	,
cord-000248-zueoyesj	188	50	68	68	CD
cord-000248-zueoyesj	188	51	,	,	,
cord-000248-zueoyesj	188	52	69	69	CD
cord-000248-zueoyesj	188	53	]	]	-RRB-
cord-000248-zueoyesj	188	54	.	.	.
cord-000248-zueoyesj	189	1	FOS	FOS	NNP
cord-000248-zueoyesj	189	2	(	(	-LRB-
cord-000248-zueoyesj	189	3	V	v	NN
cord-000248-zueoyesj	189	4	-	-	HYPH
cord-000248-zueoyesj	189	5	fos	fos	NNP
cord-000248-zueoyesj	189	6	FBJ	FBJ	NNP
cord-000248-zueoyesj	189	7	murine	murine	JJ
cord-000248-zueoyesj	189	8	osteosarcoma	osteosarcoma	NN
cord-000248-zueoyesj	189	9	viral	viral	JJ
cord-000248-zueoyesj	189	10	oncogene	oncogene	NN
cord-000248-zueoyesj	189	11	homolog	homolog	NN
cord-000248-zueoyesj	189	12	)	)	-RRB-
cord-000248-zueoyesj	189	13	.	.	.
cord-000248-zueoyesj	190	1	A	a	DT
cord-000248-zueoyesj	190	2	probe	probe	NN
cord-000248-zueoyesj	190	3	for	for	IN
cord-000248-zueoyesj	190	4	FOS	FOS	NNP
cord-000248-zueoyesj	190	5	(	(	-LRB-
cord-000248-zueoyesj	190	6	G_811015	G_811015	NNPS
cord-000248-zueoyesj	190	7	;	;	:
cord-000248-zueoyesj	190	8	correlations	correlation	NNS
cord-000248-zueoyesj	190	9	of	of	IN
cord-000248-zueoyesj	190	10	20.9380	20.9380	CD
cord-000248-zueoyesj	190	11	and	and	CC
cord-000248-zueoyesj	190	12	20.9500	20.9500	CD
cord-000248-zueoyesj	190	13	computed	compute	VBN
cord-000248-zueoyesj	190	14	with	with	IN
cord-000248-zueoyesj	190	15	Pearson	Pearson	NNP
cord-000248-zueoyesj	190	16	and	and	CC
cord-000248-zueoyesj	190	17	Spearman	Spearman	NNP
cord-000248-zueoyesj	190	18	)	)	-RRB-
cord-000248-zueoyesj	190	19	has	have	VBZ
cord-000248-zueoyesj	190	20	a	a	DT
cord-000248-zueoyesj	190	21	similar	similar	JJ
cord-000248-zueoyesj	190	22	correlation	correlation	NN
cord-000248-zueoyesj	190	23	than	than	IN
cord-000248-zueoyesj	190	24	KLK3	KLK3	NNP
cord-000248-zueoyesj	190	25	/	/	SYM
cord-000248-zueoyesj	190	26	PSA	PSA	NNP
cord-000248-zueoyesj	190	27	.	.	.
cord-000248-zueoyesj	191	1	The	the	DT
cord-000248-zueoyesj	191	2	high	high	JJ
cord-000248-zueoyesj	191	3	rank	rank	NN
cord-000248-zueoyesj	191	4	of	of	IN
cord-000248-zueoyesj	191	5	FOS	FOS	NNP
cord-000248-zueoyesj	191	6	was	be	VBD
cord-000248-zueoyesj	191	7	unexpected	unexpected	JJ
cord-000248-zueoyesj	191	8	,	,	,
cord-000248-zueoyesj	191	9	but	but	CC
cord-000248-zueoyesj	191	10	perhaps	perhaps	RB
cord-000248-zueoyesj	191	11	it	-PRON-	PRP
cord-000248-zueoyesj	191	12	is	be	VBZ
cord-000248-zueoyesj	191	13	less	less	JJR
cord-000248-zueoyesj	191	14	of	of	IN
cord-000248-zueoyesj	191	15	a	a	DT
cord-000248-zueoyesj	191	16	surprise	surprise	NN
cord-000248-zueoyesj	191	17	for	for	IN
cord-000248-zueoyesj	191	18	some	some	DT
cord-000248-zueoyesj	191	19	experienced	experienced	JJ
cord-000248-zueoyesj	191	20	researchers	researcher	NNS
cord-000248-zueoyesj	191	21	in	in	IN
cord-000248-zueoyesj	191	22	prostate	prostate	NN
cord-000248-zueoyesj	191	23	cancer	cancer	NN
cord-000248-zueoyesj	191	24	as	as	IN
cord-000248-zueoyesj	191	25	its	-PRON-	PRP$
cord-000248-zueoyesj	191	26	role	role	NN
cord-000248-zueoyesj	191	27	has	have	VBZ
cord-000248-zueoyesj	191	28	been	be	VBN
cord-000248-zueoyesj	191	29	highlighted	highlight	VBN
cord-000248-zueoyesj	191	30	in	in	IN
cord-000248-zueoyesj	191	31	the	the	DT
cord-000248-zueoyesj	191	32	past	past	NN
cord-000248-zueoyesj	191	33	[	[	-LRB-
cord-000248-zueoyesj	191	34	70	70	CD
cord-000248-zueoyesj	191	35	,	,	,
cord-000248-zueoyesj	191	36	71	71	CD
cord-000248-zueoyesj	191	37	,	,	,
cord-000248-zueoyesj	191	38	72	72	CD
cord-000248-zueoyesj	191	39	]	]	-RRB-
cord-000248-zueoyesj	191	40	.	.	.
cord-000248-zueoyesj	192	1	Amplification	amplification	NN
cord-000248-zueoyesj	192	2	of	of	IN
cord-000248-zueoyesj	192	3	members	member	NNS
cord-000248-zueoyesj	192	4	of	of	IN
cord-000248-zueoyesj	192	5	the	the	DT
cord-000248-zueoyesj	192	6	MAPK	MAPK	NNP
cord-000248-zueoyesj	192	7	pathway	pathway	NN
cord-000248-zueoyesj	192	8	was	be	VBD
cord-000248-zueoyesj	192	9	associated	associate	VBN
cord-000248-zueoyesj	192	10	with	with	IN
cord-000248-zueoyesj	192	11	androgen	androgen	NN
cord-000248-zueoyesj	192	12	independent	independent	JJ
cord-000248-zueoyesj	192	13	prostate	prostate	NN
cord-000248-zueoyesj	192	14	cancer	cancer	NN
cord-000248-zueoyesj	192	15	,	,	,
cord-000248-zueoyesj	192	16	and	and	CC
cord-000248-zueoyesj	192	17	co	co	NN
cord-000248-zueoyesj	192	18	-	-	NN
cord-000248-zueoyesj	192	19	expression	expression	NN
cord-000248-zueoyesj	192	20	of	of	IN
cord-000248-zueoyesj	192	21	RAF1	RAF1	NNP
cord-000248-zueoyesj	192	22	,	,	,
cord-000248-zueoyesj	192	23	ERBB2	ERBB2	NNS
cord-000248-zueoyesj	192	24	/	/	SYM
cord-000248-zueoyesj	192	25	HER2	HER2	NNP
cord-000248-zueoyesj	192	26	and	and	CC
cord-000248-zueoyesj	192	27	c	c	NN
cord-000248-zueoyesj	192	28	-	-	:
cord-000248-zueoyesj	192	29	FOS	FOS	NNP
cord-000248-zueoyesj	192	30	would	would	MD
cord-000248-zueoyesj	192	31	lead	lead	VB
cord-000248-zueoyesj	192	32	to	to	IN
cord-000248-zueoyesj	192	33	this	this	DT
cord-000248-zueoyesj	192	34	phenotype	phenotype	NN
cord-000248-zueoyesj	192	35	[	[	-LRB-
cord-000248-zueoyesj	192	36	73	73	CD
cord-000248-zueoyesj	192	37	]	]	-RRB-
cord-000248-zueoyesj	192	38	.	.	.
cord-000248-zueoyesj	193	1	We	-PRON-	PRP
cord-000248-zueoyesj	193	2	will	will	MD
cord-000248-zueoyesj	193	3	not	not	RB
cord-000248-zueoyesj	193	4	discuss	discuss	VB
cord-000248-zueoyesj	193	5	in	in	IN
cord-000248-zueoyesj	193	6	depth	depth	NN
cord-000248-zueoyesj	193	7	the	the	DT
cord-000248-zueoyesj	193	8	known	know	VBN
cord-000248-zueoyesj	193	9	relationships	relationship	NNS
cord-000248-zueoyesj	193	10	between	between	IN
cord-000248-zueoyesj	193	11	FOS	FOS	NNP
cord-000248-zueoyesj	193	12	,	,	,
cord-000248-zueoyesj	193	13	Lamin	Lamin	NNP
cord-000248-zueoyesj	193	14	A	A	NNP
cord-000248-zueoyesj	193	15	/	/	SYM
cord-000248-zueoyesj	193	16	C	c	NN
cord-000248-zueoyesj	193	17	and	and	CC
cord-000248-zueoyesj	193	18	prostate	prostate	NN
cord-000248-zueoyesj	193	19	cancer	cancer	NN
cord-000248-zueoyesj	193	20	.	.	.
cord-000248-zueoyesj	194	1	We	-PRON-	PRP
cord-000248-zueoyesj	194	2	leave	leave	VBP
cord-000248-zueoyesj	194	3	this	this	DT
cord-000248-zueoyesj	194	4	discussion	discussion	NN
cord-000248-zueoyesj	194	5	for	for	IN
cord-000248-zueoyesj	194	6	later	later	RBR
cord-000248-zueoyesj	194	7	,	,	,
cord-000248-zueoyesj	194	8	as	as	IN
cord-000248-zueoyesj	194	9	Lamin	Lamin	NNP
cord-000248-zueoyesj	194	10	A	A	NNP
cord-000248-zueoyesj	194	11	/	/	SYM
cord-000248-zueoyesj	194	12	C	C	NNP
cord-000248-zueoyesj	194	13	will	will	MD
cord-000248-zueoyesj	194	14	also	also	RB
cord-000248-zueoyesj	194	15	appear	appear	VB
cord-000248-zueoyesj	194	16	in	in	IN
cord-000248-zueoyesj	194	17	our	-PRON-	PRP$
cord-000248-zueoyesj	194	18	study	study	NN
cord-000248-zueoyesj	194	19	of	of	IN
cord-000248-zueoyesj	194	20	the	the	DT
cord-000248-zueoyesj	194	21	other	other	JJ
cord-000248-zueoyesj	194	22	prostate	prostate	NN
cord-000248-zueoyesj	194	23	cancer	cancer	NN
cord-000248-zueoyesj	194	24	dataset	dataset	NN
cord-000248-zueoyesj	194	25	studied	study	VBD
cord-000248-zueoyesj	194	26	in	in	IN
cord-000248-zueoyesj	194	27	this	this	DT
cord-000248-zueoyesj	194	28	paper	paper	NN
cord-000248-zueoyesj	194	29	.	.	.
cord-000248-zueoyesj	195	1	Lamin	Lamin	NNP
cord-000248-zueoyesj	195	2	A	A	NNP
cord-000248-zueoyesj	195	3	/	/	SYM
cord-000248-zueoyesj	195	4	C	C	NNP
cord-000248-zueoyesj	195	5	appears	appear	VBZ
cord-000248-zueoyesj	195	6	as	as	IN
cord-000248-zueoyesj	195	7	a	a	DT
cord-000248-zueoyesj	195	8	member	member	NN
cord-000248-zueoyesj	195	9	of	of	IN
cord-000248-zueoyesj	195	10	a	a	DT
cord-000248-zueoyesj	195	11	set	set	NN
cord-000248-zueoyesj	195	12	of	of	IN
cord-000248-zueoyesj	195	13	genes	gene	NNS
cord-000248-zueoyesj	195	14	with	with	IN
cord-000248-zueoyesj	195	15	reduced	reduce	VBN
cord-000248-zueoyesj	195	16	expression	expression	NN
cord-000248-zueoyesj	195	17	for	for	IN
cord-000248-zueoyesj	195	18	higher	high	JJR
cord-000248-zueoyesj	195	19	grade	grade	NN
cord-000248-zueoyesj	195	20	primary	primary	JJ
cord-000248-zueoyesj	195	21	prostate	prostate	NN
cord-000248-zueoyesj	195	22	cancer	cancer	NN
cord-000248-zueoyesj	195	23	samples	sample	NNS
cord-000248-zueoyesj	195	24	(	(	-LRB-
cord-000248-zueoyesj	195	25	note	note	NN
cord-000248-zueoyesj	195	26	that	that	IN
cord-000248-zueoyesj	195	27	the	the	DT
cord-000248-zueoyesj	195	28	current	current	JJ
cord-000248-zueoyesj	195	29	analysis	analysis	NN
cord-000248-zueoyesj	195	30	that	that	WDT
cord-000248-zueoyesj	195	31	gave	give	VBD
cord-000248-zueoyesj	195	32	FOS	FOS	NNP
cord-000248-zueoyesj	195	33	as	as	IN
cord-000248-zueoyesj	195	34	a	a	DT
cord-000248-zueoyesj	195	35	biomarker	biomarker	NN
cord-000248-zueoyesj	195	36	is	be	VBZ
cord-000248-zueoyesj	195	37	on	on	IN
cord-000248-zueoyesj	195	38	lymph	lymph	NN
cord-000248-zueoyesj	195	39	node	node	NN
cord-000248-zueoyesj	195	40	metastatic	metastatic	JJ
cord-000248-zueoyesj	195	41	samples	sample	NNS
cord-000248-zueoyesj	195	42	like	like	IN
cord-000248-zueoyesj	195	43	here	here	RB
cord-000248-zueoyesj	195	44	)	)	-RRB-
cord-000248-zueoyesj	195	45	.	.	.
cord-000248-zueoyesj	196	1	However	however	RB
cord-000248-zueoyesj	196	2	,	,	,
cord-000248-zueoyesj	196	3	we	-PRON-	PRP
cord-000248-zueoyesj	196	4	would	would	MD
cord-000248-zueoyesj	196	5	like	like	VB
cord-000248-zueoyesj	196	6	to	to	TO
cord-000248-zueoyesj	196	7	point	point	VB
cord-000248-zueoyesj	196	8	out	out	RP
cord-000248-zueoyesj	196	9	a	a	DT
cord-000248-zueoyesj	196	10	connection	connection	NN
cord-000248-zueoyesj	196	11	that	that	WDT
cord-000248-zueoyesj	196	12	is	be	VBZ
cord-000248-zueoyesj	196	13	currently	currently	RB
cord-000248-zueoyesj	196	14	hypothesized	hypothesize	VBN
cord-000248-zueoyesj	196	15	between	between	IN
cord-000248-zueoyesj	196	16	Lamin	Lamin	NNP
cord-000248-zueoyesj	196	17	A	A	NNP
cord-000248-zueoyesj	196	18	/	/	SYM
cord-000248-zueoyesj	196	19	C	C	NNP
cord-000248-zueoyesj	196	20	and	and	CC
cord-000248-zueoyesj	196	21	FOS	FOS	NNP
cord-000248-zueoyesj	196	22	,	,	,
cord-000248-zueoyesj	196	23	the	the	DT
cord-000248-zueoyesj	196	24	gene	gene	NN
cord-000248-zueoyesj	196	25	we	-PRON-	PRP
cord-000248-zueoyesj	196	26	have	have	VBP
cord-000248-zueoyesj	196	27	just	just	RB
cord-000248-zueoyesj	196	28	discussed	discuss	VBN
cord-000248-zueoyesj	196	29	.	.	.
cord-000248-zueoyesj	197	1	Ivorra	Ivorra	NNP
cord-000248-zueoyesj	197	2	et	et	NNP
cord-000248-zueoyesj	197	3	al	al	NNP
cord-000248-zueoyesj	197	4	.	.	NNP
cord-000248-zueoyesj	197	5	have	have	VBP
cord-000248-zueoyesj	197	6	recently	recently	RB
cord-000248-zueoyesj	197	7	proposed	propose	VBN
cord-000248-zueoyesj	197	8	that	that	IN
cord-000248-zueoyesj	197	9	'	'	''
cord-000248-zueoyesj	197	10	'	'	``
cord-000248-zueoyesj	197	11	lamin	lamin	NN
cord-000248-zueoyesj	197	12	A	a	DT
cord-000248-zueoyesj	197	13	overexpression	overexpression	NN
cord-000248-zueoyesj	197	14	causes	cause	VBZ
cord-000248-zueoyesj	197	15	growth	growth	NN
cord-000248-zueoyesj	197	16	arrest	arrest	NN
cord-000248-zueoyesj	197	17	,	,	,
cord-000248-zueoyesj	197	18	and	and	CC
cord-000248-zueoyesj	197	19	ectopic	ectopic	JJ
cord-000248-zueoyesj	197	20	c	c	NN
cord-000248-zueoyesj	197	21	-	-	:
cord-000248-zueoyesj	197	22	Fos	Fos	NNP
cord-000248-zueoyesj	197	23	partially	partially	RB
cord-000248-zueoyesj	197	24	overcomes	overcome	VBZ
cord-000248-zueoyesj	197	25	lamin	lamin	NNP
cord-000248-zueoyesj	197	26	A	A	NNP
cord-000248-zueoyesj	197	27	/	/	SYM
cord-000248-zueoyesj	197	28	C	c	NN
cord-000248-zueoyesj	197	29	-	-	HYPH
cord-000248-zueoyesj	197	30	induced	induce	VBN
cord-000248-zueoyesj	197	31	cell	cell	NN
cord-000248-zueoyesj	197	32	cycle	cycle	NN
cord-000248-zueoyesj	197	33	alterations	alteration	NNS
cord-000248-zueoyesj	197	34	.	.	.
cord-000248-zueoyesj	198	1	We	-PRON-	PRP
cord-000248-zueoyesj	198	2	propose	propose	VBP
cord-000248-zueoyesj	198	3	lamin	lamin	NNP
cord-000248-zueoyesj	198	4	A	A	NNP
cord-000248-zueoyesj	198	5	/	/	SYM
cord-000248-zueoyesj	198	6	C	C	NNP
cord-000248-zueoyesj	198	7	-	-	HYPH
cord-000248-zueoyesj	198	8	mediated	mediate	VBN
cord-000248-zueoyesj	198	9	c	c	NN
cord-000248-zueoyesj	198	10	-	-	:
cord-000248-zueoyesj	198	11	Fos	Fos	NNP
cord-000248-zueoyesj	198	12	sequestration	sequestration	NN
cord-000248-zueoyesj	198	13	at	at	IN
cord-000248-zueoyesj	198	14	the	the	DT
cord-000248-zueoyesj	198	15	nuclear	nuclear	JJ
cord-000248-zueoyesj	198	16	envelope	envelope	NN
cord-000248-zueoyesj	198	17	as	as	IN
cord-000248-zueoyesj	198	18	a	a	DT
cord-000248-zueoyesj	198	19	novel	novel	JJ
cord-000248-zueoyesj	198	20	mechanism	mechanism	NN
cord-000248-zueoyesj	198	21	of	of	IN
cord-000248-zueoyesj	198	22	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	198	23	and	and	CC
cord-000248-zueoyesj	198	24	cell	cell	NN
cord-000248-zueoyesj	198	25	cycle	cycle	NN
cord-000248-zueoyesj	198	26	control	control	NN
cord-000248-zueoyesj	198	27	'	'	''
cord-000248-zueoyesj	198	28	'	'	''
cord-000248-zueoyesj	198	29	[	[	-LRB-
cord-000248-zueoyesj	198	30	74	74	CD
cord-000248-zueoyesj	198	31	]	]	-RRB-
cord-000248-zueoyesj	198	32	.	.	.
cord-000248-zueoyesj	199	1	In	in	IN
cord-000248-zueoyesj	199	2	addition	addition	NN
cord-000248-zueoyesj	199	3	:	:	:
cord-000248-zueoyesj	199	4	'	'	''
cord-000248-zueoyesj	199	5	'	'	''
cord-000248-zueoyesj	199	6	c	c	NN
cord-000248-zueoyesj	199	7	-	-	:
cord-000248-zueoyesj	199	8	Fos	Fos	NNP
cord-000248-zueoyesj	199	9	accumulation	accumulation	NN
cord-000248-zueoyesj	199	10	within	within	IN
cord-000248-zueoyesj	199	11	the	the	DT
cord-000248-zueoyesj	199	12	extraction	extraction	NN
cord-000248-zueoyesj	199	13	-	-	HYPH
cord-000248-zueoyesj	199	14	resistant	resistant	JJ
cord-000248-zueoyesj	199	15	nuclear	nuclear	JJ
cord-000248-zueoyesj	199	16	fraction	fraction	NN
cord-000248-zueoyesj	199	17	(	(	-LRB-
cord-000248-zueoyesj	199	18	ERNF	ERNF	NNP
cord-000248-zueoyesj	199	19	)	)	-RRB-
cord-000248-zueoyesj	199	20	and	and	CC
cord-000248-zueoyesj	199	21	its	-PRON-	PRP$
cord-000248-zueoyesj	199	22	interaction	interaction	NN
cord-000248-zueoyesj	199	23	with	with	IN
cord-000248-zueoyesj	199	24	lamin	lamin	NNP
cord-000248-zueoyesj	199	25	A	A	NNP
cord-000248-zueoyesj	199	26	are	be	VBP
cord-000248-zueoyesj	199	27	reduced	reduce	VBN
cord-000248-zueoyesj	199	28	and	and	CC
cord-000248-zueoyesj	199	29	enhanced	enhance	VBN
cord-000248-zueoyesj	199	30	by	by	IN
cord-000248-zueoyesj	199	31	gain	gain	NN
cord-000248-zueoyesj	199	32	-	-	HYPH
cord-000248-zueoyesj	199	33	of	of	NN
cord-000248-zueoyesj	199	34	and	and	CC
cord-000248-zueoyesj	199	35	lossof	lossof	NNP
cord-000248-zueoyesj	199	36	ERK1/2	ERK1/2	NNP
cord-000248-zueoyesj	199	37	activity	activity	NN
cord-000248-zueoyesj	199	38	,	,	,
cord-000248-zueoyesj	199	39	respectively	respectively	RB
cord-000248-zueoyesj	199	40	.	.	.
cord-000248-zueoyesj	199	41	'	'	''
cord-000248-zueoyesj	199	42	'	'	''
cord-000248-zueoyesj	200	1	[	[	-LRB-
cord-000248-zueoyesj	200	2	75	75	CD
cord-000248-zueoyesj	200	3	]	]	-RRB-
cord-000248-zueoyesj	200	4	.	.	.
cord-000248-zueoyesj	201	1	These	these	DT
cord-000248-zueoyesj	201	2	novel	novel	JJ
cord-000248-zueoyesj	201	3	interactions	interaction	NNS
cord-000248-zueoyesj	201	4	between	between	IN
cord-000248-zueoyesj	201	5	LMNA	LMNA	NNP
cord-000248-zueoyesj	201	6	and	and	CC
cord-000248-zueoyesj	201	7	FOS	FOS	NNP
cord-000248-zueoyesj	201	8	,	,	,
cord-000248-zueoyesj	201	9	their	-PRON-	PRP$
cord-000248-zueoyesj	201	10	putative	putative	JJ
cord-000248-zueoyesj	201	11	role	role	NN
cord-000248-zueoyesj	201	12	in	in	IN
cord-000248-zueoyesj	201	13	prostate	prostate	NN
cord-000248-zueoyesj	201	14	cancer	cancer	NN
cord-000248-zueoyesj	201	15	metastasis	metastasis	NN
cord-000248-zueoyesj	201	16	and	and	CC
cord-000248-zueoyesj	201	17	their	-PRON-	PRP$
cord-000248-zueoyesj	201	18	seemingly	seemingly	RB
cord-000248-zueoyesj	201	19	different	different	JJ
cord-000248-zueoyesj	201	20	behaviours	behaviour	NNS
cord-000248-zueoyesj	201	21	in	in	IN
cord-000248-zueoyesj	202	1	prostate	prostate	NN
cord-000248-zueoyesj	202	2	cancer	cancer	NN
cord-000248-zueoyesj	202	3	lymph	lymph	NN
cord-000248-zueoyesj	202	4	node	node	NN
cord-000248-zueoyesj	202	5	metastases	metastasis	NNS
cord-000248-zueoyesj	202	6	warrant	warrant	VBP
cord-000248-zueoyesj	202	7	further	further	JJ
cord-000248-zueoyesj	202	8	investigation	investigation	NN
cord-000248-zueoyesj	202	9	.	.	.
cord-000248-zueoyesj	203	1	SOX9	SOX9	NNP
cord-000248-zueoyesj	203	2	(	(	-LRB-
cord-000248-zueoyesj	203	3	SRY	sry	UH
cord-000248-zueoyesj	203	4	(	(	-LRB-
cord-000248-zueoyesj	203	5	sex	sex	NN
cord-000248-zueoyesj	203	6	determining	determine	VBG
cord-000248-zueoyesj	203	7	region	region	NN
cord-000248-zueoyesj	203	8	Y)-box	Y)-box	NNP
cord-000248-zueoyesj	203	9	9	9	CD
cord-000248-zueoyesj	203	10	)	)	-RRB-
cord-000248-zueoyesj	203	11	.	.	.
cord-000248-zueoyesj	204	1	This	this	DT
cord-000248-zueoyesj	204	2	transcription	transcription	NN
cord-000248-zueoyesj	204	3	factor	factor	NN
cord-000248-zueoyesj	204	4	has	have	VBZ
cord-000248-zueoyesj	204	5	been	be	VBN
cord-000248-zueoyesj	204	6	recently	recently	RB
cord-000248-zueoyesj	204	7	identified	identify	VBN
cord-000248-zueoyesj	204	8	as	as	IN
cord-000248-zueoyesj	204	9	having	have	VBG
cord-000248-zueoyesj	204	10	an	an	DT
cord-000248-zueoyesj	204	11	importat	importat	JJ
cord-000248-zueoyesj	204	12	role	role	NN
cord-000248-zueoyesj	204	13	during	during	IN
cord-000248-zueoyesj	204	14	embryogenesis	embryogenesis	NN
cord-000248-zueoyesj	204	15	and	and	CC
cord-000248-zueoyesj	204	16	in	in	IN
cord-000248-zueoyesj	204	17	the	the	DT
cord-000248-zueoyesj	204	18	early	early	JJ
cord-000248-zueoyesj	204	19	stages	stage	NNS
cord-000248-zueoyesj	204	20	of	of	IN
cord-000248-zueoyesj	204	21	prostate	prostate	NN
cord-000248-zueoyesj	204	22	development	development	NN
cord-000248-zueoyesj	204	23	[	[	-LRB-
cord-000248-zueoyesj	204	24	76	76	CD
cord-000248-zueoyesj	204	25	,	,	,
cord-000248-zueoyesj	204	26	77	77	CD
cord-000248-zueoyesj	204	27	]	]	-RRB-
cord-000248-zueoyesj	204	28	and	and	CC
cord-000248-zueoyesj	204	29	in	in	IN
cord-000248-zueoyesj	204	30	testis	testis	NN
cord-000248-zueoyesj	204	31	determination	determination	NN
cord-000248-zueoyesj	204	32	[	[	-LRB-
cord-000248-zueoyesj	204	33	78	78	CD
cord-000248-zueoyesj	204	34	]	]	-RRB-
cord-000248-zueoyesj	204	35	,	,	,
cord-000248-zueoyesj	204	36	processes	process	VBZ
cord-000248-zueoyesj	204	37	that	that	WDT
cord-000248-zueoyesj	204	38	link	link	VBP
cord-000248-zueoyesj	204	39	SOX9	sox9	CD
cord-000248-zueoyesj	204	40	upregulation	upregulation	NN
cord-000248-zueoyesj	204	41	to	to	IN
cord-000248-zueoyesj	204	42	cancer	cancer	NN
cord-000248-zueoyesj	204	43	development	development	NN
cord-000248-zueoyesj	204	44	[	[	-LRB-
cord-000248-zueoyesj	204	45	79	79	CD
cord-000248-zueoyesj	204	46	]	]	-RRB-
cord-000248-zueoyesj	204	47	.	.	.
cord-000248-zueoyesj	205	1	Basal	basal	JJ
cord-000248-zueoyesj	205	2	epithelial	epithelial	JJ
cord-000248-zueoyesj	205	3	cells	cell	NNS
cord-000248-zueoyesj	205	4	do	do	VBP
cord-000248-zueoyesj	205	5	express	express	VB
cord-000248-zueoyesj	205	6	SOX9	SOX9	NNP
cord-000248-zueoyesj	205	7	in	in	IN
cord-000248-zueoyesj	205	8	a	a	DT
cord-000248-zueoyesj	205	9	normal	normal	JJ
cord-000248-zueoyesj	205	10	prostate	prostate	NN
cord-000248-zueoyesj	205	11	.	.	.
cord-000248-zueoyesj	206	1	While	while	IN
cord-000248-zueoyesj	206	2	there	there	EX
cord-000248-zueoyesj	206	3	exists	exist	VBZ
cord-000248-zueoyesj	206	4	no	no	DT
cord-000248-zueoyesj	206	5	detectable	detectable	JJ
cord-000248-zueoyesj	206	6	expression	expression	NN
cord-000248-zueoyesj	206	7	in	in	IN
cord-000248-zueoyesj	206	8	lumina	lumina	NNP
cord-000248-zueoyesj	206	9	epithelial	epithelial	JJ
cord-000248-zueoyesj	206	10	cells	cell	NNS
cord-000248-zueoyesj	206	11	,	,	,
cord-000248-zueoyesj	206	12	SOX9	SOX9	NNP
cord-000248-zueoyesj	206	13	has	have	VBZ
cord-000248-zueoyesj	206	14	already	already	RB
cord-000248-zueoyesj	206	15	been	be	VBN
cord-000248-zueoyesj	206	16	reported	report	VBN
cord-000248-zueoyesj	206	17	as	as	IN
cord-000248-zueoyesj	206	18	'	'	''
cord-000248-zueoyesj	206	19	'	'	''
cord-000248-zueoyesj	206	20	expressed	express	VBN
cord-000248-zueoyesj	206	21	in	in	IN
cord-000248-zueoyesj	206	22	primary	primary	JJ
cord-000248-zueoyesj	206	23	prostate	prostate	NN
cord-000248-zueoyesj	206	24	cancer	cancer	NN
cord-000248-zueoyesj	206	25	in	in	IN
cord-000248-zueoyesj	206	26	vivo	vivo	NN
cord-000248-zueoyesj	206	27	,	,	,
cord-000248-zueoyesj	206	28	at	at	IN
cord-000248-zueoyesj	206	29	a	a	DT
cord-000248-zueoyesj	206	30	higher	high	JJR
cord-000248-zueoyesj	206	31	frequency	frequency	NN
cord-000248-zueoyesj	206	32	in	in	IN
cord-000248-zueoyesj	206	33	recurrent	recurrent	JJ
cord-000248-zueoyesj	206	34	prostate	prostate	NN
cord-000248-zueoyesj	206	35	cancer	cancer	NN
cord-000248-zueoyesj	206	36	and	and	CC
cord-000248-zueoyesj	206	37	in	in	IN
cord-000248-zueoyesj	206	38	prostate	prostate	NN
cord-000248-zueoyesj	206	39	cancer	cancer	NN
cord-000248-zueoyesj	206	40	cell	cell	NN
cord-000248-zueoyesj	206	41	lines	line	NNS
cord-000248-zueoyesj	206	42	(	(	-LRB-
cord-000248-zueoyesj	206	43	LNCaP	lncap	NN
cord-000248-zueoyesj	206	44	,	,	,
cord-000248-zueoyesj	206	45	CWR22	CWR22	NNP
cord-000248-zueoyesj	206	46	,	,	,
cord-000248-zueoyesj	206	47	PC3	PC3	NNP
cord-000248-zueoyesj	206	48	,	,	,
cord-000248-zueoyesj	206	49	and	and	CC
cord-000248-zueoyesj	206	50	DU145	du145	FW
cord-000248-zueoyesj	206	51	)	)	-RRB-
cord-000248-zueoyesj	206	52	'	'	''
cord-000248-zueoyesj	206	53	'	'	''
cord-000248-zueoyesj	206	54	[	[	-LRB-
cord-000248-zueoyesj	206	55	80	80	CD
cord-000248-zueoyesj	206	56	]	]	-RRB-
cord-000248-zueoyesj	206	57	.	.	.
cord-000248-zueoyesj	207	1	Wang	Wang	NNP
cord-000248-zueoyesj	207	2	et	et	NNP
cord-000248-zueoyesj	207	3	al	al	NNP
cord-000248-zueoyesj	207	4	.	.	.
cord-000248-zueoyesj	208	1	,	,	,
cord-000248-zueoyesj	208	2	also	also	RB
cord-000248-zueoyesj	208	3	in	in	IN
cord-000248-zueoyesj	208	4	[	[	-LRB-
cord-000248-zueoyesj	208	5	80	80	CD
cord-000248-zueoyesj	208	6	]	]	-RRB-
cord-000248-zueoyesj	208	7	add	add	VBP
cord-000248-zueoyesj	208	8	that	that	DT
cord-000248-zueoyesj	208	9	:	:	:
cord-000248-zueoyesj	208	10	''	''	''
cord-000248-zueoyesj	209	1	Significantly	significantly	RB
cord-000248-zueoyesj	209	2	,	,	,
cord-000248-zueoyesj	209	3	down	down	IN
cord-000248-zueoyesj	209	4	-	-	HYPH
cord-000248-zueoyesj	209	5	regulation	regulation	NN
cord-000248-zueoyesj	209	6	of	of	IN
cord-000248-zueoyesj	209	7	SOX9	SOX9	NNP
cord-000248-zueoyesj	209	8	by	by	IN
cord-000248-zueoyesj	209	9	siRNA	siRNA	NNP
cord-000248-zueoyesj	209	10	in	in	IN
cord-000248-zueoyesj	209	11	prostate	prostate	NN
cord-000248-zueoyesj	209	12	cancer	cancer	NN
cord-000248-zueoyesj	209	13	cells	cell	NNS
cord-000248-zueoyesj	209	14	reduced	reduce	VBN
cord-000248-zueoyesj	209	15	endogenous	endogenous	JJ
cord-000248-zueoyesj	209	16	AR	AR	NNP
cord-000248-zueoyesj	209	17	protein	protein	NN
cord-000248-zueoyesj	209	18	levels	level	NNS
cord-000248-zueoyesj	209	19	,	,	,
cord-000248-zueoyesj	209	20	and	and	CC
cord-000248-zueoyesj	209	21	cell	cell	NN
cord-000248-zueoyesj	209	22	growth	growth	NN
cord-000248-zueoyesj	209	23	indicating	indicate	VBG
cord-000248-zueoyesj	209	24	that	that	IN
cord-000248-zueoyesj	209	25	SOX9	SOX9	NNP
cord-000248-zueoyesj	209	26	contributes	contribute	VBZ
cord-000248-zueoyesj	209	27	to	to	IN
cord-000248-zueoyesj	209	28	AR	AR	NNP
cord-000248-zueoyesj	209	29	regulation	regulation	NN
cord-000248-zueoyesj	209	30	and	and	CC
cord-000248-zueoyesj	209	31	decreased	decrease	VBD
cord-000248-zueoyesj	209	32	cellular	cellular	JJ
cord-000248-zueoyesj	209	33	proliferation	proliferation	NN
cord-000248-zueoyesj	209	34	.	.	.
cord-000248-zueoyesj	210	1	These	these	DT
cord-000248-zueoyesj	210	2	results	result	NNS
cord-000248-zueoyesj	210	3	indicate	indicate	VBP
cord-000248-zueoyesj	210	4	that	that	IN
cord-000248-zueoyesj	210	5	SOX9	SOX9	NNP
cord-000248-zueoyesj	210	6	in	in	IN
cord-000248-zueoyesj	210	7	prostate	prostate	NN
cord-000248-zueoyesj	210	8	basal	basal	NN
cord-000248-zueoyesj	210	9	cells	cell	NNS
cord-000248-zueoyesj	210	10	supports	support	VBZ
cord-000248-zueoyesj	210	11	the	the	DT
cord-000248-zueoyesj	210	12	development	development	NN
cord-000248-zueoyesj	210	13	and	and	CC
cord-000248-zueoyesj	210	14	maintenance	maintenance	NN
cord-000248-zueoyesj	210	15	of	of	IN
cord-000248-zueoyesj	210	16	the	the	DT
cord-000248-zueoyesj	210	17	luminal	luminal	JJ
cord-000248-zueoyesj	210	18	epithelium	epithelium	NN
cord-000248-zueoyesj	210	19	and	and	CC
cord-000248-zueoyesj	210	20	that	that	IN
cord-000248-zueoyesj	210	21	a	a	DT
cord-000248-zueoyesj	210	22	subset	subset	NN
cord-000248-zueoyesj	210	23	of	of	IN
cord-000248-zueoyesj	210	24	prostate	prostate	NN
cord-000248-zueoyesj	210	25	cancer	cancer	NN
cord-000248-zueoyesj	210	26	cells	cell	NNS
cord-000248-zueoyesj	210	27	may	may	MD
cord-000248-zueoyesj	210	28	escape	escape	VB
cord-000248-zueoyesj	210	29	basal	basal	NN
cord-000248-zueoyesj	210	30	cell	cell	NN
cord-000248-zueoyesj	210	31	requirements	requirement	NNS
cord-000248-zueoyesj	210	32	through	through	IN
cord-000248-zueoyesj	210	33	SOX9	SOX9	NNP
cord-000248-zueoyesj	210	34	expression	expression	NN
cord-000248-zueoyesj	210	35	.	.	.
cord-000248-zueoyesj	210	36	'	'	''
cord-000248-zueoyesj	210	37	'	'	''
cord-000248-zueoyesj	211	1	An	an	DT
cord-000248-zueoyesj	211	2	increased	increase	VBN
cord-000248-zueoyesj	211	3	value	value	NN
cord-000248-zueoyesj	211	4	of	of	IN
cord-000248-zueoyesj	211	5	SOX9	SOX9	NNP
cord-000248-zueoyesj	211	6	expression	expression	NN
cord-000248-zueoyesj	211	7	in	in	IN
cord-000248-zueoyesj	211	8	advanced	advanced	JJ
cord-000248-zueoyesj	211	9	prostate	prostate	NN
cord-000248-zueoyesj	211	10	cancer	cancer	NN
cord-000248-zueoyesj	211	11	has	have	VBZ
cord-000248-zueoyesj	211	12	been	be	VBN
cord-000248-zueoyesj	211	13	associated	associate	VBN
cord-000248-zueoyesj	211	14	to	to	IN
cord-000248-zueoyesj	211	15	tumor	tumor	NN
cord-000248-zueoyesj	211	16	progression	progression	NN
cord-000248-zueoyesj	211	17	and	and	CC
cord-000248-zueoyesj	211	18	the	the	DT
cord-000248-zueoyesj	211	19	epithelial	epithelial	NN
cord-000248-zueoyesj	211	20	-	-	HYPH
cord-000248-zueoyesj	211	21	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	211	22	transition	transition	NN
cord-000248-zueoyesj	211	23	[	[	-LRB-
cord-000248-zueoyesj	211	24	81	81	CD
cord-000248-zueoyesj	211	25	]	]	-RRB-
cord-000248-zueoyesj	211	26	.	.	.
cord-000248-zueoyesj	212	1	SOX9	SOX9	NNP
cord-000248-zueoyesj	212	2	expression	expression	NN
cord-000248-zueoyesj	212	3	has	have	VBZ
cord-000248-zueoyesj	212	4	been	be	VBN
cord-000248-zueoyesj	212	5	associated	associate	VBN
cord-000248-zueoyesj	212	6	with	with	IN
cord-000248-zueoyesj	212	7	a	a	DT
cord-000248-zueoyesj	212	8	putative	putative	JJ
cord-000248-zueoyesj	212	9	subgroup	subgroup	NN
cord-000248-zueoyesj	212	10	of	of	IN
cord-000248-zueoyesj	212	11	prostate	prostate	NN
cord-000248-zueoyesj	212	12	cancer	cancer	NN
cord-000248-zueoyesj	212	13	[	[	-LRB-
cord-000248-zueoyesj	212	14	82	82	CD
cord-000248-zueoyesj	212	15	]	]	-RRB-
cord-000248-zueoyesj	212	16	,	,	,
cord-000248-zueoyesj	212	17	associated	associate	VBN
cord-000248-zueoyesj	212	18	to	to	IN
cord-000248-zueoyesj	212	19	lymph	lymph	NN
cord-000248-zueoyesj	212	20	-	-	HYPH
cord-000248-zueoyesj	212	21	node	node	NN
cord-000248-zueoyesj	212	22	metastasis	metastasis	NN
cord-000248-zueoyesj	212	23	(	(	-LRB-
cord-000248-zueoyesj	212	24	as	as	RB
cord-000248-zueoyesj	212	25	seems	seem	VBZ
cord-000248-zueoyesj	212	26	to	to	TO
cord-000248-zueoyesj	212	27	be	be	VB
cord-000248-zueoyesj	212	28	the	the	DT
cord-000248-zueoyesj	212	29	case	case	NN
cord-000248-zueoyesj	212	30	in	in	IN
cord-000248-zueoyesj	212	31	this	this	DT
cord-000248-zueoyesj	212	32	dataset	dataset	NN
cord-000248-zueoyesj	212	33	)	)	-RRB-
cord-000248-zueoyesj	212	34	and	and	CC
cord-000248-zueoyesj	212	35	has	have	VBZ
cord-000248-zueoyesj	212	36	a	a	DT
cord-000248-zueoyesj	212	37	know	know	NN
cord-000248-zueoyesj	212	38	role	role	NN
cord-000248-zueoyesj	212	39	in	in	IN
cord-000248-zueoyesj	212	40	chondrogenic	chondrogenic	JJ
cord-000248-zueoyesj	212	41	differentiation	differentiation	NN
cord-000248-zueoyesj	212	42	processes	process	NNS
cord-000248-zueoyesj	212	43	[	[	-LRB-
cord-000248-zueoyesj	212	44	83	83	CD
cord-000248-zueoyesj	212	45	]	]	-RRB-
cord-000248-zueoyesj	212	46	.	.	.
cord-000248-zueoyesj	213	1	KLK3	KLK3	NNP
cord-000248-zueoyesj	213	2	/	/	SYM
cord-000248-zueoyesj	213	3	PSA	PSA	NNP
cord-000248-zueoyesj	213	4	-(Kallikrein	-(kallikrein	RB
cord-000248-zueoyesj	213	5	-	-	HYPH
cord-000248-zueoyesj	213	6	related	relate	VBN
cord-000248-zueoyesj	213	7	peptidase	peptidase	NN
cord-000248-zueoyesj	213	8	3)/Prostate	3)/prostate	CD
cord-000248-zueoyesj	213	9	Specific	specific	JJ
cord-000248-zueoyesj	213	10	Antigen	Antigen	NNP
cord-000248-zueoyesj	213	11	.	.	.
cord-000248-zueoyesj	214	1	To	to	TO
cord-000248-zueoyesj	214	2	finalize	finalize	VB
cord-000248-zueoyesj	214	3	our	-PRON-	PRP$
cord-000248-zueoyesj	214	4	initial	initial	JJ
cord-000248-zueoyesj	214	5	discussion	discussion	NN
cord-000248-zueoyesj	214	6	on	on	IN
cord-000248-zueoyesj	214	7	this	this	DT
cord-000248-zueoyesj	214	8	dataset	dataset	NN
cord-000248-zueoyesj	214	9	,	,	,
cord-000248-zueoyesj	214	10	we	-PRON-	PRP
cord-000248-zueoyesj	214	11	address	address	VBP
cord-000248-zueoyesj	214	12	KLK3	KLK3	NNP
cord-000248-zueoyesj	214	13	.	.	.
cord-000248-zueoyesj	215	1	The	the	DT
cord-000248-zueoyesj	215	2	high	high	JJ
cord-000248-zueoyesj	215	3	ranking	ranking	NN
cord-000248-zueoyesj	215	4	of	of	IN
cord-000248-zueoyesj	215	5	KLK3	KLK3	NNP
cord-000248-zueoyesj	215	6	/	/	SYM
cord-000248-zueoyesj	215	7	PSA	PSA	NNP
cord-000248-zueoyesj	215	8	in	in	IN
cord-000248-zueoyesj	215	9	our	-PRON-	PRP$
cord-000248-zueoyesj	215	10	list	list	NN
cord-000248-zueoyesj	215	11	is	be	VBZ
cord-000248-zueoyesj	215	12	perhaps	perhaps	RB
cord-000248-zueoyesj	215	13	one	one	CD
cord-000248-zueoyesj	215	14	of	of	IN
cord-000248-zueoyesj	215	15	the	the	DT
cord-000248-zueoyesj	215	16	most	most	RBS
cord-000248-zueoyesj	215	17	remarkable	remarkable	JJ
cord-000248-zueoyesj	215	18	retrodictive	retrodictive	JJ
cord-000248-zueoyesj	215	19	outcomes	outcome	NNS
cord-000248-zueoyesj	215	20	of	of	IN
cord-000248-zueoyesj	215	21	our	-PRON-	PRP$
cord-000248-zueoyesj	215	22	approach	approach	NN
cord-000248-zueoyesj	215	23	.	.	.
cord-000248-zueoyesj	216	1	KLK3	KLK3	NNP
cord-000248-zueoyesj	216	2	/	/	SYM
cord-000248-zueoyesj	216	3	PSA	PSA	NNP
cord-000248-zueoyesj	216	4	(	(	-LRB-
cord-000248-zueoyesj	216	5	also	also	RB
cord-000248-zueoyesj	216	6	known	know	VBN
cord-000248-zueoyesj	216	7	as	as	IN
cord-000248-zueoyesj	216	8	Prostate	Prostate	NNP
cord-000248-zueoyesj	216	9	Specific	Specific	NNP
cord-000248-zueoyesj	216	10	Antigen	Antigen	NNP
cord-000248-zueoyesj	216	11	)	)	-RRB-
cord-000248-zueoyesj	216	12	is	be	VBZ
cord-000248-zueoyesj	216	13	a	a	DT
cord-000248-zueoyesj	216	14	conspiquous	conspiquous	JJ
cord-000248-zueoyesj	216	15	member	member	NN
cord-000248-zueoyesj	216	16	of	of	IN
cord-000248-zueoyesj	216	17	our	-PRON-	PRP$
cord-000248-zueoyesj	216	18	top	top	JJ
cord-000248-zueoyesj	216	19	rank	rank	NN
cord-000248-zueoyesj	216	20	list	list	NN
cord-000248-zueoyesj	216	21	.	.	.
cord-000248-zueoyesj	217	1	It	-PRON-	PRP
cord-000248-zueoyesj	217	2	is	be	VBZ
cord-000248-zueoyesj	217	3	perhaps	perhaps	RB
cord-000248-zueoyesj	217	4	the	the	DT
cord-000248-zueoyesj	217	5	best	good	JJS
cord-000248-zueoyesj	217	6	blood	blood	NN
cord-000248-zueoyesj	217	7	biomarker	biomarker	NN
cord-000248-zueoyesj	217	8	for	for	IN
cord-000248-zueoyesj	217	9	prostate	prostate	NN
cord-000248-zueoyesj	217	10	cancer	cancer	NN
cord-000248-zueoyesj	217	11	screening	screening	NN
cord-000248-zueoyesj	217	12	.	.	.
cord-000248-zueoyesj	218	1	Its	-PRON-	PRP$
cord-000248-zueoyesj	218	2	relevance	relevance	NN
cord-000248-zueoyesj	218	3	and	and	CC
cord-000248-zueoyesj	218	4	popularity	popularity	NN
cord-000248-zueoyesj	218	5	as	as	IN
cord-000248-zueoyesj	218	6	a	a	DT
cord-000248-zueoyesj	218	7	target	target	NN
cord-000248-zueoyesj	218	8	of	of	IN
cord-000248-zueoyesj	218	9	studies	study	NNS
cord-000248-zueoyesj	218	10	is	be	VBZ
cord-000248-zueoyesj	218	11	so	so	RB
cord-000248-zueoyesj	218	12	wide	wide	JJ
cord-000248-zueoyesj	218	13	that	that	IN
cord-000248-zueoyesj	218	14	it	-PRON-	PRP
cord-000248-zueoyesj	218	15	makes	make	VBZ
cord-000248-zueoyesj	218	16	unfeasible	unfeasible	JJ
cord-000248-zueoyesj	218	17	any	any	DT
cord-000248-zueoyesj	218	18	serious	serious	JJ
cord-000248-zueoyesj	218	19	attempt	attempt	NN
cord-000248-zueoyesj	218	20	to	to	TO
cord-000248-zueoyesj	218	21	uncover	uncover	VB
cord-000248-zueoyesj	218	22	its	-PRON-	PRP$
cord-000248-zueoyesj	218	23	relevance	relevance	NN
cord-000248-zueoyesj	218	24	in	in	IN
cord-000248-zueoyesj	218	25	the	the	DT
cord-000248-zueoyesj	218	26	prostate	prostate	NN
cord-000248-zueoyesj	218	27	cancer	cancer	NN
cord-000248-zueoyesj	218	28	literature	literature	NN
cord-000248-zueoyesj	218	29	.	.	.
cord-000248-zueoyesj	219	1	A	a	DT
cord-000248-zueoyesj	219	2	search	search	NN
cord-000248-zueoyesj	219	3	using	use	VBG
cord-000248-zueoyesj	219	4	PubMed	PubMed	NNP
cord-000248-zueoyesj	219	5	using	use	VBG
cord-000248-zueoyesj	219	6	the	the	DT
cord-000248-zueoyesj	219	7	keyword	keyword	NN
cord-000248-zueoyesj	219	8	'	'	``
cord-000248-zueoyesj	219	9	KLK3	KLK3	NNP
cord-000248-zueoyesj	219	10	'	'	''
cord-000248-zueoyesj	219	11	(	(	-LRB-
cord-000248-zueoyesj	219	12	and	and	CC
cord-000248-zueoyesj	219	13	the	the	DT
cord-000248-zueoyesj	219	14	other	other	JJ
cord-000248-zueoyesj	219	15	alias	alias	NNP
cord-000248-zueoyesj	219	16	names	name	NNS
cord-000248-zueoyesj	219	17	of	of	IN
cord-000248-zueoyesj	219	18	this	this	DT
cord-000248-zueoyesj	219	19	gene	gene	NN
cord-000248-zueoyesj	219	20	)	)	-RRB-
cord-000248-zueoyesj	219	21	reveals	reveal	VBZ
cord-000248-zueoyesj	219	22	a	a	DT
cord-000248-zueoyesj	219	23	total	total	NN
cord-000248-zueoyesj	219	24	of	of	IN
cord-000248-zueoyesj	219	25	11,429	11,429	CD
cord-000248-zueoyesj	219	26	published	publish	VBN
cord-000248-zueoyesj	219	27	papers	paper	NNS
cord-000248-zueoyesj	219	28	.	.	.
cord-000248-zueoyesj	220	1	Of	of	RB
cord-000248-zueoyesj	220	2	course	course	RB
cord-000248-zueoyesj	220	3	,	,	,
cord-000248-zueoyesj	220	4	many	many	JJ
cord-000248-zueoyesj	220	5	of	of	IN
cord-000248-zueoyesj	220	6	these	these	DT
cord-000248-zueoyesj	220	7	publications	publication	NNS
cord-000248-zueoyesj	220	8	relate	relate	VBP
cord-000248-zueoyesj	220	9	to	to	IN
cord-000248-zueoyesj	220	10	its	-PRON-	PRP$
cord-000248-zueoyesj	220	11	role	role	NN
cord-000248-zueoyesj	220	12	for	for	IN
cord-000248-zueoyesj	220	13	early	early	JJ
cord-000248-zueoyesj	220	14	screening	screening	NN
cord-000248-zueoyesj	220	15	,	,	,
cord-000248-zueoyesj	220	16	but	but	CC
cord-000248-zueoyesj	220	17	in	in	IN
cord-000248-zueoyesj	220	18	this	this	DT
cord-000248-zueoyesj	220	19	study	study	NN
cord-000248-zueoyesj	220	20	we	-PRON-	PRP
cord-000248-zueoyesj	220	21	are	be	VBP
cord-000248-zueoyesj	220	22	uncovering	uncover	VBG
cord-000248-zueoyesj	220	23	its	-PRON-	PRP$
cord-000248-zueoyesj	220	24	role	role	NN
cord-000248-zueoyesj	220	25	as	as	IN
cord-000248-zueoyesj	220	26	a	a	DT
cord-000248-zueoyesj	220	27	tissue	tissue	NN
cord-000248-zueoyesj	220	28	biomarker	biomarker	NN
cord-000248-zueoyesj	220	29	.	.	.
cord-000248-zueoyesj	221	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	221	2	results	result	NNS
cord-000248-zueoyesj	221	3	echoes	echo	VBZ
cord-000248-zueoyesj	221	4	a	a	DT
cord-000248-zueoyesj	221	5	recent	recent	JJ
cord-000248-zueoyesj	221	6	contribution	contribution	NN
cord-000248-zueoyesj	221	7	by	by	IN
cord-000248-zueoyesj	221	8	S.	S.	NNP
cord-000248-zueoyesj	221	9	Miyano	Miyano	NNP
cord-000248-zueoyesj	221	10	's	's	POS
cord-000248-zueoyesj	221	11	and	and	CC
cord-000248-zueoyesj	221	12	his	-PRON-	PRP$
cord-000248-zueoyesj	221	13	collaborators	collaborator	NNS
cord-000248-zueoyesj	221	14	[	[	-LRB-
cord-000248-zueoyesj	221	15	84	84	CD
cord-000248-zueoyesj	221	16	]	]	-RRB-
cord-000248-zueoyesj	221	17	on	on	IN
cord-000248-zueoyesj	221	18	a	a	DT
cord-000248-zueoyesj	221	19	massive	massive	JJ
cord-000248-zueoyesj	221	20	meta	meta	NN
cord-000248-zueoyesj	221	21	-	-	HYPH
cord-000248-zueoyesj	221	22	analysis	analysis	NN
cord-000248-zueoyesj	221	23	of	of	IN
cord-000248-zueoyesj	221	24	microarray	microarray	NN
cord-000248-zueoyesj	221	25	datasets	dataset	NNS
cord-000248-zueoyesj	221	26	.	.	.
cord-000248-zueoyesj	222	1	It	-PRON-	PRP
cord-000248-zueoyesj	222	2	is	be	VBZ
cord-000248-zueoyesj	222	3	also	also	RB
cord-000248-zueoyesj	222	4	in	in	IN
cord-000248-zueoyesj	222	5	line	line	NN
cord-000248-zueoyesj	222	6	with	with	IN
cord-000248-zueoyesj	222	7	results	result	NNS
cord-000248-zueoyesj	222	8	from	from	IN
cord-000248-zueoyesj	222	9	clinical	clinical	JJ
cord-000248-zueoyesj	222	10	studies	study	NNS
cord-000248-zueoyesj	222	11	that	that	WDT
cord-000248-zueoyesj	222	12	indicate	indicate	VBP
cord-000248-zueoyesj	222	13	that	that	IN
cord-000248-zueoyesj	222	14	a	a	DT
cord-000248-zueoyesj	222	15	5-year	5-year	CD
cord-000248-zueoyesj	222	16	PSA	PSA	NNP
cord-000248-zueoyesj	222	17	value	value	NN
cord-000248-zueoyesj	222	18	is	be	VBZ
cord-000248-zueoyesj	222	19	useful	useful	JJ
cord-000248-zueoyesj	222	20	for	for	IN
cord-000248-zueoyesj	222	21	predicting	predict	VBG
cord-000248-zueoyesj	222	22	prostate	prostate	NN
cord-000248-zueoyesj	222	23	cancer	cancer	NN
cord-000248-zueoyesj	222	24	recurrence	recurrence	NN
cord-000248-zueoyesj	222	25	.	.	.
cord-000248-zueoyesj	223	1	[	[	-LRB-
cord-000248-zueoyesj	223	2	85	85	CD
cord-000248-zueoyesj	223	3	]	]	-RRB-
cord-000248-zueoyesj	223	4	.	.	.
cord-000248-zueoyesj	224	1	Certainly	certainly	RB
cord-000248-zueoyesj	224	2	the	the	DT
cord-000248-zueoyesj	224	3	dynamics	dynamic	NNS
cord-000248-zueoyesj	224	4	of	of	IN
cord-000248-zueoyesj	224	5	PSA	PSA	NNP
cord-000248-zueoyesj	224	6	,	,	,
cord-000248-zueoyesj	224	7	now	now	RB
cord-000248-zueoyesj	224	8	perhaps	perhaps	RB
cord-000248-zueoyesj	224	9	with	with	IN
cord-000248-zueoyesj	224	10	FOS	FOS	NNP
cord-000248-zueoyesj	224	11	and	and	CC
cord-000248-zueoyesj	224	12	SOX9	SOX9	NNP
cord-000248-zueoyesj	224	13	added	add	VBD
cord-000248-zueoyesj	224	14	to	to	IN
cord-000248-zueoyesj	224	15	the	the	DT
cord-000248-zueoyesj	224	16	set	set	NN
cord-000248-zueoyesj	224	17	of	of	IN
cord-000248-zueoyesj	224	18	biomarkers	biomarker	NNS
cord-000248-zueoyesj	224	19	of	of	IN
cord-000248-zueoyesj	224	20	interest	interest	NN
cord-000248-zueoyesj	224	21	,	,	,
cord-000248-zueoyesj	224	22	warrant	warrant	VBP
cord-000248-zueoyesj	224	23	further	further	JJ
cord-000248-zueoyesj	224	24	investigation	investigation	NN
cord-000248-zueoyesj	224	25	for	for	IN
cord-000248-zueoyesj	224	26	patient	patient	JJ
cord-000248-zueoyesj	224	27	population	population	NN
cord-000248-zueoyesj	224	28	stratification	stratification	NN
cord-000248-zueoyesj	224	29	after	after	IN
cord-000248-zueoyesj	224	30	initial	initial	JJ
cord-000248-zueoyesj	224	31	treatment	treatment	NN
cord-000248-zueoyesj	224	32	.	.	.
cord-000248-zueoyesj	225	1	The	the	DT
cord-000248-zueoyesj	225	2	biomarkers	biomarker	NNS
cord-000248-zueoyesj	225	3	discussed	discuss	VBN
cord-000248-zueoyesj	225	4	in	in	IN
cord-000248-zueoyesj	225	5	this	this	DT
cord-000248-zueoyesj	225	6	section	section	NN
cord-000248-zueoyesj	225	7	warrant	warrant	VBP
cord-000248-zueoyesj	225	8	further	further	JJ
cord-000248-zueoyesj	225	9	investigation	investigation	NN
cord-000248-zueoyesj	225	10	in	in	IN
cord-000248-zueoyesj	225	11	prediction	prediction	NN
cord-000248-zueoyesj	225	12	of	of	IN
cord-000248-zueoyesj	225	13	lymph	lymph	NN
cord-000248-zueoyesj	225	14	-	-	HYPH
cord-000248-zueoyesj	225	15	node	node	NN
cord-000248-zueoyesj	225	16	metastasis	metastasis	NN
cord-000248-zueoyesj	225	17	and	and	CC
cord-000248-zueoyesj	225	18	clinical	clinical	JJ
cord-000248-zueoyesj	225	19	management	management	NN
cord-000248-zueoyesj	225	20	of	of	IN
cord-000248-zueoyesj	225	21	prostate	prostate	NN
cord-000248-zueoyesj	225	22	cancer	cancer	NN
cord-000248-zueoyesj	225	23	[	[	-LRB-
cord-000248-zueoyesj	225	24	86	86	CD
cord-000248-zueoyesj	225	25	,	,	,
cord-000248-zueoyesj	225	26	87	87	CD
cord-000248-zueoyesj	225	27	,	,	,
cord-000248-zueoyesj	225	28	88	88	CD
cord-000248-zueoyesj	225	29	,	,	,
cord-000248-zueoyesj	225	30	89	89	CD
cord-000248-zueoyesj	225	31	,	,	,
cord-000248-zueoyesj	225	32	90	90	CD
cord-000248-zueoyesj	225	33	,	,	,
cord-000248-zueoyesj	225	34	91	91	CD
cord-000248-zueoyesj	225	35	,	,	,
cord-000248-zueoyesj	225	36	92	92	CD
cord-000248-zueoyesj	225	37	,	,	,
cord-000248-zueoyesj	225	38	93	93	CD
cord-000248-zueoyesj	225	39	,	,	,
cord-000248-zueoyesj	225	40	94	94	CD
cord-000248-zueoyesj	225	41	,	,	,
cord-000248-zueoyesj	225	42	95	95	CD
cord-000248-zueoyesj	225	43	,	,	,
cord-000248-zueoyesj	225	44	96	96	CD
cord-000248-zueoyesj	225	45	,	,	,
cord-000248-zueoyesj	225	46	97	97	CD
cord-000248-zueoyesj	225	47	,	,	,
cord-000248-zueoyesj	225	48	98	98	CD
cord-000248-zueoyesj	225	49	,	,	,
cord-000248-zueoyesj	225	50	99	99	CD
cord-000248-zueoyesj	225	51	,	,	,
cord-000248-zueoyesj	225	52	100	100	CD
cord-000248-zueoyesj	225	53	,	,	,
cord-000248-zueoyesj	225	54	101	101	CD
cord-000248-zueoyesj	225	55	,	,	,
cord-000248-zueoyesj	225	56	102	102	CD
cord-000248-zueoyesj	225	57	,	,	,
cord-000248-zueoyesj	225	58	103	103	CD
cord-000248-zueoyesj	225	59	,	,	,
cord-000248-zueoyesj	225	60	104	104	CD
cord-000248-zueoyesj	225	61	,	,	,
cord-000248-zueoyesj	225	62	105	105	CD
cord-000248-zueoyesj	225	63	,	,	,
cord-000248-zueoyesj	225	64	106	106	CD
cord-000248-zueoyesj	225	65	,	,	,
cord-000248-zueoyesj	225	66	107	107	CD
cord-000248-zueoyesj	225	67	,	,	,
cord-000248-zueoyesj	225	68	108	108	CD
cord-000248-zueoyesj	225	69	,	,	,
cord-000248-zueoyesj	225	70	109	109	CD
cord-000248-zueoyesj	225	71	]	]	-RRB-
cord-000248-zueoyesj	225	72	.	.	.
cord-000248-zueoyesj	226	1	We	-PRON-	PRP
cord-000248-zueoyesj	226	2	refer	refer	VBP
cord-000248-zueoyesj	226	3	the	the	DT
cord-000248-zueoyesj	226	4	reader	reader	NN
cord-000248-zueoyesj	226	5	to	to	IN
cord-000248-zueoyesj	226	6	the	the	DT
cord-000248-zueoyesj	226	7	Supplementary	Supplementary	NNP
cord-000248-zueoyesj	226	8	Material	Material	NNP
cord-000248-zueoyesj	226	9	to	to	TO
cord-000248-zueoyesj	226	10	have	have	VB
cord-000248-zueoyesj	226	11	a	a	DT
cord-000248-zueoyesj	226	12	complete	complete	JJ
cord-000248-zueoyesj	226	13	list	list	NN
cord-000248-zueoyesj	226	14	of	of	IN
cord-000248-zueoyesj	226	15	probes	probe	NNS
cord-000248-zueoyesj	226	16	and	and	CC
cord-000248-zueoyesj	226	17	their	-PRON-	PRP$
cord-000248-zueoyesj	226	18	correlations	correlation	NNS
cord-000248-zueoyesj	226	19	with	with	IN
cord-000248-zueoyesj	226	20	the	the	DT
cord-000248-zueoyesj	226	21	Information	Information	NNP
cord-000248-zueoyesj	226	22	Theory	Theory	NNP
cord-000248-zueoyesj	226	23	quantifiers	quantifier	NNS
cord-000248-zueoyesj	226	24	.	.	.
cord-000248-zueoyesj	227	1	The	the	DT
cord-000248-zueoyesj	227	2	following	following	JJ
cord-000248-zueoyesj	227	3	sections	section	NNS
cord-000248-zueoyesj	227	4	present	present	VBP
cord-000248-zueoyesj	227	5	the	the	DT
cord-000248-zueoyesj	227	6	results	result	NNS
cord-000248-zueoyesj	227	7	that	that	WDT
cord-000248-zueoyesj	227	8	we	-PRON-	PRP
cord-000248-zueoyesj	227	9	obtained	obtain	VBD
cord-000248-zueoyesj	227	10	with	with	IN
cord-000248-zueoyesj	227	11	a	a	DT
cord-000248-zueoyesj	227	12	melanoma	melanoma	NN
cord-000248-zueoyesj	227	13	dataset	dataset	NN
cord-000248-zueoyesj	227	14	.	.	.
cord-000248-zueoyesj	228	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	228	2	aim	aim	NN
cord-000248-zueoyesj	228	3	is	be	VBZ
cord-000248-zueoyesj	228	4	to	to	TO
cord-000248-zueoyesj	228	5	observe	observe	VB
cord-000248-zueoyesj	228	6	if	if	IN
cord-000248-zueoyesj	228	7	variations	variation	NNS
cord-000248-zueoyesj	228	8	of	of	IN
cord-000248-zueoyesj	228	9	the	the	DT
cord-000248-zueoyesj	228	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	228	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	228	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	228	13	and	and	CC
cord-000248-zueoyesj	228	14	the	the	DT
cord-000248-zueoyesj	228	15	statistical	statistical	JJ
cord-000248-zueoyesj	228	16	complexity	complexity	NN
cord-000248-zueoyesj	228	17	measures	measure	NNS
cord-000248-zueoyesj	228	18	,	,	,
cord-000248-zueoyesj	228	19	MPR	mpr	NN
cord-000248-zueoyesj	228	20	-	-	HYPH
cord-000248-zueoyesj	228	21	complexity	complexity	NN
cord-000248-zueoyesj	228	22	and	and	CC
cord-000248-zueoyesj	228	23	the	the	DT
cord-000248-zueoyesj	228	24	modified	modify	VBN
cord-000248-zueoyesj	228	25	forms	form	NNS
cord-000248-zueoyesj	228	26	M	M	NNP
cord-000248-zueoyesj	228	27	-	-	HYPH
cord-000248-zueoyesj	228	28	normal	normal	JJ
cord-000248-zueoyesj	228	29	and	and	CC
cord-000248-zueoyesj	228	30	M	m	NN
cord-000248-zueoyesj	228	31	-	-	HYPH
cord-000248-zueoyesj	228	32	metastases	metastasis	NNS
cord-000248-zueoyesj	228	33	,	,	,
cord-000248-zueoyesj	228	34	provide	provide	VB
cord-000248-zueoyesj	228	35	interesting	interesting	JJ
cord-000248-zueoyesj	228	36	results	result	NNS
cord-000248-zueoyesj	228	37	in	in	IN
cord-000248-zueoyesj	228	38	a	a	DT
cord-000248-zueoyesj	228	39	different	different	JJ
cord-000248-zueoyesj	228	40	disease	disease	NN
cord-000248-zueoyesj	228	41	and	and	CC
cord-000248-zueoyesj	228	42	experimental	experimental	JJ
cord-000248-zueoyesj	228	43	setting	setting	NN
cord-000248-zueoyesj	228	44	.	.	.
cord-000248-zueoyesj	229	1	In	in	IN
cord-000248-zueoyesj	229	2	this	this	DT
cord-000248-zueoyesj	229	3	case	case	NN
cord-000248-zueoyesj	229	4	we	-PRON-	PRP
cord-000248-zueoyesj	229	5	have	have	VBP
cord-000248-zueoyesj	229	6	selected	select	VBN
cord-000248-zueoyesj	229	7	a	a	DT
cord-000248-zueoyesj	229	8	gene	gene	NN
cord-000248-zueoyesj	229	9	expression	expression	NN
cord-000248-zueoyesj	229	10	dataset	dataset	NN
cord-000248-zueoyesj	229	11	from	from	IN
cord-000248-zueoyesj	229	12	Haqq	Haqq	NNP
cord-000248-zueoyesj	229	13	et	et	FW
cord-000248-zueoyesj	229	14	al	al	NNP
cord-000248-zueoyesj	229	15	.	.	.
cord-000248-zueoyesj	230	1	[	[	-LRB-
cord-000248-zueoyesj	230	2	110	110	CD
cord-000248-zueoyesj	230	3	]	]	-RRB-
cord-000248-zueoyesj	230	4	containing	contain	VBG
cord-000248-zueoyesj	230	5	information	information	NN
cord-000248-zueoyesj	230	6	of	of	IN
cord-000248-zueoyesj	230	7	14,772	14,772	CD
cord-000248-zueoyesj	230	8	cDNAs	cdna	NNS
cord-000248-zueoyesj	230	9	in	in	IN
cord-000248-zueoyesj	230	10	37	37	CD
cord-000248-zueoyesj	230	11	samples	sample	NNS
cord-000248-zueoyesj	230	12	(	(	-LRB-
cord-000248-zueoyesj	230	13	Figure	figure	VB
cord-000248-zueoyesj	230	14	two	two	CD
cord-000248-zueoyesj	230	15	from	from	IN
cord-000248-zueoyesj	230	16	the	the	DT
cord-000248-zueoyesj	230	17	[	[	-LRB-
cord-000248-zueoyesj	230	18	110	110	CD
cord-000248-zueoyesj	230	19	]	]	-RRB-
cord-000248-zueoyesj	230	20	)	)	-RRB-
cord-000248-zueoyesj	230	21	.	.	.
cord-000248-zueoyesj	231	1	The	the	DT
cord-000248-zueoyesj	231	2	37	37	CD
cord-000248-zueoyesj	231	3	samples	sample	NNS
cord-000248-zueoyesj	231	4	include	include	VBP
cord-000248-zueoyesj	231	5	3	3	CD
cord-000248-zueoyesj	231	6	normal	normal	JJ
cord-000248-zueoyesj	231	7	skin	skin	NN
cord-000248-zueoyesj	231	8	,	,	,
cord-000248-zueoyesj	231	9	9	9	CD
cord-000248-zueoyesj	231	10	nevi	nevus	NNS
cord-000248-zueoyesj	231	11	,	,	,
cord-000248-zueoyesj	231	12	6	6	CD
cord-000248-zueoyesj	231	13	primary	primary	JJ
cord-000248-zueoyesj	231	14	melanoma	melanoma	NN
cord-000248-zueoyesj	231	15	and	and	CC
cord-000248-zueoyesj	231	16	19	19	CD
cord-000248-zueoyesj	231	17	melanoma	melanoma	NN
cord-000248-zueoyesj	231	18	metastases	metastasis	NNS
cord-000248-zueoyesj	231	19	.	.	.
cord-000248-zueoyesj	232	1	This	this	DT
cord-000248-zueoyesj	232	2	datasets	dataset	NNS
cord-000248-zueoyesj	232	3	has	have	VBZ
cord-000248-zueoyesj	232	4	more	more	JJR
cord-000248-zueoyesj	232	5	phenotypical	phenotypical	JJ
cord-000248-zueoyesj	232	6	characteristics	characteristic	NNS
cord-000248-zueoyesj	232	7	for	for	IN
cord-000248-zueoyesj	232	8	the	the	DT
cord-000248-zueoyesj	232	9	group	group	NN
cord-000248-zueoyesj	232	10	of	of	IN
cord-000248-zueoyesj	232	11	samples	sample	NNS
cord-000248-zueoyesj	232	12	.	.	.
cord-000248-zueoyesj	233	1	After	after	IN
cord-000248-zueoyesj	233	2	an	an	DT
cord-000248-zueoyesj	233	3	initial	initial	JJ
cord-000248-zueoyesj	233	4	process	process	NN
cord-000248-zueoyesj	233	5	of	of	IN
cord-000248-zueoyesj	233	6	data	datum	NNS
cord-000248-zueoyesj	233	7	cleaning	cleaning	NN
cord-000248-zueoyesj	233	8	,	,	,
cord-000248-zueoyesj	233	9	we	-PRON-	PRP
cord-000248-zueoyesj	233	10	removed	remove	VBD
cord-000248-zueoyesj	233	11	35	35	CD
cord-000248-zueoyesj	233	12	probes	probe	NNS
cord-000248-zueoyesj	233	13	which	which	WDT
cord-000248-zueoyesj	233	14	had	have	VBD
cord-000248-zueoyesj	233	15	an	an	DT
cord-000248-zueoyesj	233	16	unsually	unsually	RB
cord-000248-zueoyesj	233	17	high	high	JJ
cord-000248-zueoyesj	233	18	expression	expression	NN
cord-000248-zueoyesj	233	19	value	value	NN
cord-000248-zueoyesj	233	20	on	on	IN
cord-000248-zueoyesj	233	21	only	only	RB
cord-000248-zueoyesj	233	22	a	a	DT
cord-000248-zueoyesj	233	23	few	few	JJ
cord-000248-zueoyesj	233	24	samples	sample	NNS
cord-000248-zueoyesj	233	25	,	,	,
cord-000248-zueoyesj	233	26	in	in	IN
cord-000248-zueoyesj	233	27	some	some	DT
cord-000248-zueoyesj	233	28	cases	case	NNS
cord-000248-zueoyesj	233	29	on	on	IN
cord-000248-zueoyesj	233	30	a	a	DT
cord-000248-zueoyesj	233	31	single	single	JJ
cord-000248-zueoyesj	233	32	one	one	CD
cord-000248-zueoyesj	233	33	.	.	.
cord-000248-zueoyesj	234	1	The	the	DT
cord-000248-zueoyesj	234	2	dataset	dataset	NN
cord-000248-zueoyesj	234	3	we	-PRON-	PRP
cord-000248-zueoyesj	234	4	work	work	VBP
cord-000248-zueoyesj	234	5	with	with	IN
cord-000248-zueoyesj	234	6	from	from	IN
cord-000248-zueoyesj	234	7	original	original	JJ
cord-000248-zueoyesj	234	8	contributed	contribute	VBN
cord-000248-zueoyesj	234	9	by	by	IN
cord-000248-zueoyesj	234	10	Haqq	Haqq	NNP
cord-000248-zueoyesj	234	11	et	et	FW
cord-000248-zueoyesj	234	12	al.consists	al.consists	NNP
cord-000248-zueoyesj	234	13	of	of	IN
cord-000248-zueoyesj	234	14	14,737	14,737	CD
cord-000248-zueoyesj	234	15	probes	probe	NNS
cord-000248-zueoyesj	234	16	.	.	.
cord-000248-zueoyesj	235	1	First	first	RB
cord-000248-zueoyesj	235	2	,	,	,
cord-000248-zueoyesj	235	3	we	-PRON-	PRP
cord-000248-zueoyesj	235	4	computed	compute	VBD
cord-000248-zueoyesj	235	5	the	the	DT
cord-000248-zueoyesj	235	6	Normalized	Normalized	NNP
cord-000248-zueoyesj	235	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	235	8	Entropy	Entropy	NNP
cord-000248-zueoyesj	235	9	and	and	CC
cord-000248-zueoyesj	235	10	the	the	DT
cord-000248-zueoyesj	235	11	MPR	MPR	NNP
cord-000248-zueoyesj	235	12	-	-	HYPH
cord-000248-zueoyesj	235	13	Statistical	Statistical	NNP
cord-000248-zueoyesj	235	14	Complexity	Complexity	NNP
cord-000248-zueoyesj	235	15	for	for	IN
cord-000248-zueoyesj	235	16	each	each	DT
cord-000248-zueoyesj	235	17	sample	sample	NN
cord-000248-zueoyesj	235	18	(	(	-LRB-
cord-000248-zueoyesj	235	19	refer	refer	VB
cord-000248-zueoyesj	235	20	to	to	IN
cord-000248-zueoyesj	235	21	the	the	DT
cord-000248-zueoyesj	235	22	'	'	``
cord-000248-zueoyesj	235	23	Materials	material	NNS
cord-000248-zueoyesj	235	24	and	and	CC
cord-000248-zueoyesj	235	25	Methods	Methods	NNPS
cord-000248-zueoyesj	235	26	'	'	POS
cord-000248-zueoyesj	235	27	section	section	NN
cord-000248-zueoyesj	235	28	for	for	IN
cord-000248-zueoyesj	235	29	a	a	DT
cord-000248-zueoyesj	235	30	detailed	detailed	JJ
cord-000248-zueoyesj	235	31	presentation	presentation	NN
cord-000248-zueoyesj	235	32	of	of	IN
cord-000248-zueoyesj	235	33	these	these	DT
cord-000248-zueoyesj	235	34	calculations	calculation	NNS
cord-000248-zueoyesj	235	35	)	)	-RRB-
cord-000248-zueoyesj	235	36	.	.	.
cord-000248-zueoyesj	236	1	Figure	figure	NN
cord-000248-zueoyesj	236	2	4	4	CD
cord-000248-zueoyesj	236	3	shows	show	VBZ
cord-000248-zueoyesj	236	4	the	the	DT
cord-000248-zueoyesj	236	5	values	value	NNS
cord-000248-zueoyesj	236	6	of	of	IN
cord-000248-zueoyesj	236	7	these	these	DT
cord-000248-zueoyesj	236	8	quantifiers	quantifier	NNS
cord-000248-zueoyesj	236	9	for	for	IN
cord-000248-zueoyesj	236	10	each	each	DT
cord-000248-zueoyesj	236	11	sample	sample	NN
cord-000248-zueoyesj	236	12	.	.	.
cord-000248-zueoyesj	237	1	We	-PRON-	PRP
cord-000248-zueoyesj	237	2	first	first	RB
cord-000248-zueoyesj	237	3	observe	observe	VBP
cord-000248-zueoyesj	237	4	an	an	DT
cord-000248-zueoyesj	237	5	important	important	JJ
cord-000248-zueoyesj	237	6	difference	difference	NN
cord-000248-zueoyesj	237	7	between	between	IN
cord-000248-zueoyesj	237	8	Figure	figure	NN
cord-000248-zueoyesj	237	9	1	1	CD
cord-000248-zueoyesj	237	10	and	and	CC
cord-000248-zueoyesj	237	11	Figure	Figure	NNP
cord-000248-zueoyesj	237	12	4	4	CD
cord-000248-zueoyesj	237	13	.	.	.
cord-000248-zueoyesj	238	1	In	in	IN
cord-000248-zueoyesj	238	2	this	this	DT
cord-000248-zueoyesj	238	3	melanoma	melanoma	NN
cord-000248-zueoyesj	238	4	dataset	dataset	NN
cord-000248-zueoyesj	238	5	,	,	,
cord-000248-zueoyesj	238	6	neither	neither	CC
cord-000248-zueoyesj	238	7	the	the	DT
cord-000248-zueoyesj	238	8	use	use	NN
cord-000248-zueoyesj	238	9	of	of	IN
cord-000248-zueoyesj	238	10	the	the	DT
cord-000248-zueoyesj	238	11	Normalized	Normalized	NNP
cord-000248-zueoyesj	238	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	238	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	238	14	nor	nor	CC
cord-000248-zueoyesj	238	15	the	the	DT
cord-000248-zueoyesj	238	16	MPR	MPR	NNP
cord-000248-zueoyesj	238	17	-	-	HYPH
cord-000248-zueoyesj	238	18	complexity	complexity	NN
cord-000248-zueoyesj	238	19	helps	help	VBZ
cord-000248-zueoyesj	238	20	to	to	TO
cord-000248-zueoyesj	238	21	discriminate	discriminate	VB
cord-000248-zueoyesj	238	22	between	between	IN
cord-000248-zueoyesj	238	23	normal	normal	JJ
cord-000248-zueoyesj	238	24	skin	skin	NN
cord-000248-zueoyesj	238	25	,	,	,
cord-000248-zueoyesj	238	26	nevi	nevus	NNS
cord-000248-zueoyesj	238	27	,	,	,
cord-000248-zueoyesj	238	28	primary	primary	JJ
cord-000248-zueoyesj	238	29	and	and	CC
cord-000248-zueoyesj	238	30	metastastic	metastastic	JJ
cord-000248-zueoyesj	238	31	melanomas	melanoma	NNS
cord-000248-zueoyesj	238	32	.	.	.
cord-000248-zueoyesj	239	1	Nevertheless	nevertheless	RB
cord-000248-zueoyesj	239	2	,	,	,
cord-000248-zueoyesj	239	3	we	-PRON-	PRP
cord-000248-zueoyesj	239	4	decided	decide	VBD
cord-000248-zueoyesj	239	5	to	to	TO
cord-000248-zueoyesj	239	6	present	present	VB
cord-000248-zueoyesj	239	7	this	this	DT
cord-000248-zueoyesj	239	8	figure	figure	NN
cord-000248-zueoyesj	239	9	for	for	IN
cord-000248-zueoyesj	239	10	methodological	methodological	JJ
cord-000248-zueoyesj	239	11	reasons	reason	NNS
cord-000248-zueoyesj	239	12	.	.	.
cord-000248-zueoyesj	240	1	We	-PRON-	PRP
cord-000248-zueoyesj	240	2	envision	envision	VBP
cord-000248-zueoyesj	240	3	that	that	IN
cord-000248-zueoyesj	240	4	some	some	DT
cord-000248-zueoyesj	240	5	researchers	researcher	NNS
cord-000248-zueoyesj	240	6	will	will	MD
cord-000248-zueoyesj	240	7	calculate	calculate	VB
cord-000248-zueoyesj	240	8	the	the	DT
cord-000248-zueoyesj	240	9	Normalized	Normalized	NNP
cord-000248-zueoyesj	240	10	Shannon	Shannon	NNP
cord-000248-zueoyesj	240	11	Entropy	Entropy	NNP
cord-000248-zueoyesj	240	12	and	and	CC
cord-000248-zueoyesj	240	13	MPR	MPR	NNP
cord-000248-zueoyesj	240	14	-	-	HYPH
cord-000248-zueoyesj	240	15	complexity	complexity	NN
cord-000248-zueoyesj	240	16	using	use	VBG
cord-000248-zueoyesj	240	17	all	all	PDT
cord-000248-zueoyesj	240	18	the	the	DT
cord-000248-zueoyesj	240	19	probes	probe	NNS
cord-000248-zueoyesj	240	20	.	.	.
cord-000248-zueoyesj	241	1	We	-PRON-	PRP
cord-000248-zueoyesj	241	2	note	note	VBP
cord-000248-zueoyesj	241	3	that	that	IN
cord-000248-zueoyesj	241	4	in	in	IN
cord-000248-zueoyesj	241	5	Figure	figure	NN
cord-000248-zueoyesj	241	6	one	one	CD
cord-000248-zueoyesj	241	7	of	of	IN
cord-000248-zueoyesj	241	8	Haqq	Haqq	NNP
cord-000248-zueoyesj	241	9	et	et	NNP
cord-000248-zueoyesj	241	10	al	al	NNP
cord-000248-zueoyesj	241	11	's	's	POS
cord-000248-zueoyesj	241	12	original	original	JJ
cord-000248-zueoyesj	241	13	paper	paper	NN
cord-000248-zueoyesj	241	14	,	,	,
cord-000248-zueoyesj	241	15	the	the	DT
cord-000248-zueoyesj	241	16	whole	whole	JJ
cord-000248-zueoyesj	241	17	probe	probe	NN
cord-000248-zueoyesj	241	18	set	set	NN
cord-000248-zueoyesj	241	19	was	be	VBD
cord-000248-zueoyesj	241	20	previously	previously	RB
cord-000248-zueoyesj	241	21	filtered	filter	VBN
cord-000248-zueoyesj	241	22	by	by	IN
cord-000248-zueoyesj	241	23	selecting	select	VBG
cord-000248-zueoyesj	241	24	those	those	DT
cord-000248-zueoyesj	241	25	which	which	WDT
cord-000248-zueoyesj	241	26	vary	vary	VBP
cord-000248-zueoyesj	241	27	across	across	IN
cord-000248-zueoyesj	241	28	samples	sample	NNS
cord-000248-zueoyesj	241	29	,	,	,
cord-000248-zueoyesj	241	30	thus	thus	RB
cord-000248-zueoyesj	241	31	indicating	indicate	VBG
cord-000248-zueoyesj	241	32	that	that	IN
cord-000248-zueoyesj	241	33	they	-PRON-	PRP
cord-000248-zueoyesj	241	34	may	may	MD
cord-000248-zueoyesj	241	35	have	have	VB
cord-000248-zueoyesj	241	36	information	information	NN
cord-000248-zueoyesj	241	37	about	about	IN
cord-000248-zueoyesj	241	38	disease	disease	NN
cord-000248-zueoyesj	241	39	subtypes	subtype	NNS
cord-000248-zueoyesj	241	40	(	(	-LRB-
cord-000248-zueoyesj	241	41	although	although	IN
cord-000248-zueoyesj	241	42	the	the	DT
cord-000248-zueoyesj	241	43	phenotypic	phenotypic	JJ
cord-000248-zueoyesj	241	44	types	type	NNS
cord-000248-zueoyesj	241	45	were	be	VBD
cord-000248-zueoyesj	241	46	not	not	RB
cord-000248-zueoyesj	241	47	biasing	bias	VBG
cord-000248-zueoyesj	241	48	the	the	DT
cord-000248-zueoyesj	241	49	selection	selection	NN
cord-000248-zueoyesj	241	50	)	)	-RRB-
cord-000248-zueoyesj	241	51	.	.	.
cord-000248-zueoyesj	242	1	In	in	IN
cord-000248-zueoyesj	242	2	this	this	DT
cord-000248-zueoyesj	242	3	case	case	NN
cord-000248-zueoyesj	242	4	we	-PRON-	PRP
cord-000248-zueoyesj	242	5	want	want	VBP
cord-000248-zueoyesj	242	6	to	to	TO
cord-000248-zueoyesj	242	7	illustrate	illustrate	VB
cord-000248-zueoyesj	242	8	both	both	CC
cord-000248-zueoyesj	242	9	the	the	DT
cord-000248-zueoyesj	242	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	242	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	242	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	242	13	and	and	CC
cord-000248-zueoyesj	242	14	MPR	MPR	NNP
cord-000248-zueoyesj	242	15	-	-	HYPH
cord-000248-zueoyesj	242	16	complexity	complexity	NN
cord-000248-zueoyesj	242	17	calculated	calculate	VBN
cord-000248-zueoyesj	242	18	using	use	VBG
cord-000248-zueoyesj	242	19	all	all	PDT
cord-000248-zueoyesj	242	20	the	the	DT
cord-000248-zueoyesj	242	21	probes	probe	NNS
cord-000248-zueoyesj	242	22	does	do	VBZ
cord-000248-zueoyesj	242	23	not	not	RB
cord-000248-zueoyesj	242	24	give	give	VB
cord-000248-zueoyesj	242	25	the	the	DT
cord-000248-zueoyesj	242	26	expected	expect	VBN
cord-000248-zueoyesj	242	27	benefits	benefit	NNS
cord-000248-zueoyesj	242	28	.	.	.
cord-000248-zueoyesj	243	1	We	-PRON-	PRP
cord-000248-zueoyesj	243	2	will	will	MD
cord-000248-zueoyesj	243	3	now	now	RB
cord-000248-zueoyesj	243	4	see	see	VB
cord-000248-zueoyesj	243	5	the	the	DT
cord-000248-zueoyesj	243	6	benefits	benefit	NNS
cord-000248-zueoyesj	243	7	of	of	IN
cord-000248-zueoyesj	243	8	using	use	VBG
cord-000248-zueoyesj	243	9	the	the	DT
cord-000248-zueoyesj	243	10	M	M	NNP
cord-000248-zueoyesj	243	11	-	-	HYPH
cord-000248-zueoyesj	243	12	complexities	complexity	NNS
cord-000248-zueoyesj	243	13	.	.	.
cord-000248-zueoyesj	244	1	As	as	IN
cord-000248-zueoyesj	244	2	we	-PRON-	PRP
cord-000248-zueoyesj	244	3	did	do	VBD
cord-000248-zueoyesj	244	4	for	for	IN
cord-000248-zueoyesj	244	5	prostate	prostate	NN
cord-000248-zueoyesj	244	6	cancer	cancer	NN
cord-000248-zueoyesj	244	7	(	(	-LRB-
cord-000248-zueoyesj	244	8	see	see	VB
cord-000248-zueoyesj	244	9	Figure	Figure	NNP
cord-000248-zueoyesj	244	10	2	2	CD
cord-000248-zueoyesj	244	11	)	)	-RRB-
cord-000248-zueoyesj	244	12	,	,	,
cord-000248-zueoyesj	244	13	we	-PRON-	PRP
cord-000248-zueoyesj	244	14	aim	aim	VBP
cord-000248-zueoyesj	244	15	at	at	IN
cord-000248-zueoyesj	244	16	identifying	identify	VBG
cord-000248-zueoyesj	244	17	if	if	IN
cord-000248-zueoyesj	244	18	the	the	DT
cord-000248-zueoyesj	244	19	use	use	NN
cord-000248-zueoyesj	244	20	of	of	IN
cord-000248-zueoyesj	244	21	the	the	DT
cord-000248-zueoyesj	244	22	modified	modify	VBN
cord-000248-zueoyesj	244	23	forms	form	NNS
cord-000248-zueoyesj	244	24	of	of	IN
cord-000248-zueoyesj	244	25	the	the	DT
cord-000248-zueoyesj	244	26	statistical	statistical	JJ
cord-000248-zueoyesj	244	27	complexity	complexity	NN
cord-000248-zueoyesj	244	28	(	(	-LRB-
cord-000248-zueoyesj	244	29	the	the	DT
cord-000248-zueoyesj	244	30	M	M	NNP
cord-000248-zueoyesj	244	31	-	-	HYPH
cord-000248-zueoyesj	244	32	complexities	complexity	NNS
cord-000248-zueoyesj	244	33	)	)	-RRB-
cord-000248-zueoyesj	244	34	could	could	MD
cord-000248-zueoyesj	244	35	give	give	VB
cord-000248-zueoyesj	244	36	some	some	DT
cord-000248-zueoyesj	244	37	insight	insight	NN
cord-000248-zueoyesj	244	38	where	where	WRB
cord-000248-zueoyesj	244	39	the	the	DT
cord-000248-zueoyesj	244	40	Normalized	Normalized	NNP
cord-000248-zueoyesj	244	41	Shannon	Shannon	NNP
cord-000248-zueoyesj	244	42	Entropy	Entropy	NNP
cord-000248-zueoyesj	244	43	and	and	CC
cord-000248-zueoyesj	244	44	MPR	MPR	NNP
cord-000248-zueoyesj	244	45	-	-	HYPH
cord-000248-zueoyesj	244	46	complexity	complexity	NN
cord-000248-zueoyesj	244	47	measures	measure	NNS
cord-000248-zueoyesj	244	48	fail	fail	VBP
cord-000248-zueoyesj	244	49	.	.	.
cord-000248-zueoyesj	245	1	To	to	TO
cord-000248-zueoyesj	245	2	compute	compute	VB
cord-000248-zueoyesj	245	3	the	the	DT
cord-000248-zueoyesj	245	4	M	M	NNP
cord-000248-zueoyesj	245	5	-	-	HYPH
cord-000248-zueoyesj	245	6	normal	normal	JJ
cord-000248-zueoyesj	245	7	measure	measure	NN
cord-000248-zueoyesj	245	8	,	,	,
cord-000248-zueoyesj	245	9	we	-PRON-	PRP
cord-000248-zueoyesj	245	10	need	need	VBP
cord-000248-zueoyesj	245	11	to	to	TO
cord-000248-zueoyesj	245	12	define	define	VB
cord-000248-zueoyesj	245	13	the	the	DT
cord-000248-zueoyesj	245	14	average	average	JJ
cord-000248-zueoyesj	245	15	gene	gene	NN
cord-000248-zueoyesj	245	16	expression	expression	NN
cord-000248-zueoyesj	245	17	profile	profile	NN
cord-000248-zueoyesj	245	18	for	for	IN
cord-000248-zueoyesj	245	19	a	a	DT
cord-000248-zueoyesj	245	20	normal	normal	JJ
cord-000248-zueoyesj	245	21	cell	cell	NN
cord-000248-zueoyesj	245	22	(	(	-LRB-
cord-000248-zueoyesj	245	23	which	which	WDT
cord-000248-zueoyesj	245	24	we	-PRON-	PRP
cord-000248-zueoyesj	245	25	call	call	VBP
cord-000248-zueoyesj	245	26	P	P	NNP
cord-000248-zueoyesj	245	27	ave	ave	NNP
cord-000248-zueoyesj	245	28	)	)	-RRB-
cord-000248-zueoyesj	245	29	.	.	.
cord-000248-zueoyesj	246	1	We	-PRON-	PRP
cord-000248-zueoyesj	246	2	thus	thus	RB
cord-000248-zueoyesj	246	3	resort	resort	VBP
cord-000248-zueoyesj	246	4	to	to	IN
cord-000248-zueoyesj	246	5	the	the	DT
cord-000248-zueoyesj	246	6	three	three	CD
cord-000248-zueoyesj	246	7	normal	normal	JJ
cord-000248-zueoyesj	246	8	skin	skin	NN
cord-000248-zueoyesj	246	9	profiles	profile	NNS
cord-000248-zueoyesj	246	10	and	and	CC
cord-000248-zueoyesj	246	11	we	-PRON-	PRP
cord-000248-zueoyesj	246	12	produce	produce	VBP
cord-000248-zueoyesj	246	13	the	the	DT
cord-000248-zueoyesj	246	14	average	average	NN
cord-000248-zueoyesj	246	15	based	base	VBN
cord-000248-zueoyesj	246	16	on	on	IN
cord-000248-zueoyesj	246	17	these	these	DT
cord-000248-zueoyesj	246	18	profiles	profile	NNS
cord-000248-zueoyesj	246	19	(	(	-LRB-
cord-000248-zueoyesj	246	20	details	detail	NNS
cord-000248-zueoyesj	246	21	for	for	IN
cord-000248-zueoyesj	246	22	computing	compute	VBG
cord-000248-zueoyesj	246	23	the	the	DT
cord-000248-zueoyesj	246	24	average	average	JJ
cord-000248-zueoyesj	246	25	profiles	profile	NNS
cord-000248-zueoyesj	246	26	are	be	VBP
cord-000248-zueoyesj	246	27	given	give	VBN
cord-000248-zueoyesj	246	28	in	in	IN
cord-000248-zueoyesj	246	29	the	the	DT
cord-000248-zueoyesj	246	30	'	'	``
cord-000248-zueoyesj	246	31	Materials	material	NNS
cord-000248-zueoyesj	246	32	and	and	CC
cord-000248-zueoyesj	246	33	Methods	Methods	NNPS
cord-000248-zueoyesj	246	34	'	'	POS
cord-000248-zueoyesj	246	35	section	section	NN
cord-000248-zueoyesj	246	36	)	)	-RRB-
cord-000248-zueoyesj	246	37	.	.	.
cord-000248-zueoyesj	247	1	We	-PRON-	PRP
cord-000248-zueoyesj	247	2	call	call	VBP
cord-000248-zueoyesj	247	3	M	M	NNP
cord-000248-zueoyesj	247	4	-	-	NN
cord-000248-zueoyesj	247	5	skin	skin	NN
cord-000248-zueoyesj	247	6	the	the	DT
cord-000248-zueoyesj	247	7	resulting	result	VBG
cord-000248-zueoyesj	247	8	measure	measure	NN
cord-000248-zueoyesj	247	9	that	that	WDT
cord-000248-zueoyesj	247	10	relies	rely	VBZ
cord-000248-zueoyesj	247	11	on	on	IN
cord-000248-zueoyesj	247	12	this	this	DT
cord-000248-zueoyesj	247	13	profile	profile	NN
cord-000248-zueoyesj	247	14	.	.	.
cord-000248-zueoyesj	248	1	Analogously	analogously	RB
cord-000248-zueoyesj	248	2	,	,	,
cord-000248-zueoyesj	248	3	we	-PRON-	PRP
cord-000248-zueoyesj	248	4	need	need	VBP
cord-000248-zueoyesj	248	5	to	to	TO
cord-000248-zueoyesj	248	6	compute	compute	VB
cord-000248-zueoyesj	248	7	a	a	DT
cord-000248-zueoyesj	248	8	pattern	pattern	NN
cord-000248-zueoyesj	248	9	for	for	IN
cord-000248-zueoyesj	248	10	M	m	NN
cord-000248-zueoyesj	248	11	-	-	HYPH
cord-000248-zueoyesj	248	12	metastasis	metastasis	NN
cord-000248-zueoyesj	248	13	,	,	,
cord-000248-zueoyesj	248	14	and	and	CC
cord-000248-zueoyesj	248	15	we	-PRON-	PRP
cord-000248-zueoyesj	248	16	proceed	proceed	VBP
cord-000248-zueoyesj	248	17	to	to	TO
cord-000248-zueoyesj	248	18	calculate	calculate	VB
cord-000248-zueoyesj	248	19	the	the	DT
cord-000248-zueoyesj	248	20	P	p	NN
cord-000248-zueoyesj	248	21	ave	ave	NNP
cord-000248-zueoyesj	248	22	profile	profile	NN
cord-000248-zueoyesj	248	23	averaging	average	VBG
cord-000248-zueoyesj	248	24	over	over	IN
cord-000248-zueoyesj	248	25	the	the	DT
cord-000248-zueoyesj	248	26	19	19	CD
cord-000248-zueoyesj	248	27	metastases	metastasis	NNS
cord-000248-zueoyesj	248	28	samples	sample	NNS
cord-000248-zueoyesj	248	29	.	.	.
cord-000248-zueoyesj	249	1	The	the	DT
cord-000248-zueoyesj	249	2	result	result	NN
cord-000248-zueoyesj	249	3	is	be	VBZ
cord-000248-zueoyesj	249	4	encouraging	encouraging	JJ
cord-000248-zueoyesj	249	5	,	,	,
cord-000248-zueoyesj	249	6	as	as	IN
cord-000248-zueoyesj	249	7	samples	sample	NNS
cord-000248-zueoyesj	249	8	plotted	plot	VBN
cord-000248-zueoyesj	249	9	in	in	IN
cord-000248-zueoyesj	249	10	the	the	DT
cord-000248-zueoyesj	249	11	(	(	-LRB-
cord-000248-zueoyesj	249	12	M	m	NN
cord-000248-zueoyesj	249	13	-	-	HYPH
cord-000248-zueoyesj	249	14	skin	skin	NN
cord-000248-zueoyesj	249	15	,	,	,
cord-000248-zueoyesj	249	16	M	M	NNP
cord-000248-zueoyesj	249	17	-	-	HYPH
cord-000248-zueoyesj	249	18	metastasis)-plane	metastasis)-plane	NNP
cord-000248-zueoyesj	249	19	cluster	cluster	NN
cord-000248-zueoyesj	249	20	in	in	IN
cord-000248-zueoyesj	249	21	groups	group	NNS
cord-000248-zueoyesj	249	22	,	,	,
cord-000248-zueoyesj	249	23	showing	show	VBG
cord-000248-zueoyesj	249	24	an	an	DT
cord-000248-zueoyesj	249	25	important	important	JJ
cord-000248-zueoyesj	249	26	M	m	NN
cord-000248-zueoyesj	249	27	-	-	HYPH
cord-000248-zueoyesj	249	28	skin	skin	NN
cord-000248-zueoyesj	249	29	complexity	complexity	NN
cord-000248-zueoyesj	249	30	transition	transition	NN
cord-000248-zueoyesj	249	31	between	between	IN
cord-000248-zueoyesj	249	32	normal	normal	JJ
cord-000248-zueoyesj	249	33	skin	skin	NN
cord-000248-zueoyesj	249	34	cells	cell	NNS
cord-000248-zueoyesj	249	35	and	and	CC
cord-000248-zueoyesj	249	36	nevi	nevus	NNS
cord-000248-zueoyesj	249	37	.	.	.
cord-000248-zueoyesj	250	1	Most	most	RBS
cord-000248-zueoyesj	250	2	importantly	importantly	RB
cord-000248-zueoyesj	250	3	,	,	,
cord-000248-zueoyesj	250	4	this	this	DT
cord-000248-zueoyesj	250	5	method	method	NN
cord-000248-zueoyesj	250	6	naturally	naturally	RB
cord-000248-zueoyesj	250	7	shows	show	VBZ
cord-000248-zueoyesj	250	8	that	that	IN
cord-000248-zueoyesj	250	9	some	some	DT
cord-000248-zueoyesj	250	10	of	of	IN
cord-000248-zueoyesj	250	11	the	the	DT
cord-000248-zueoyesj	250	12	metastatic	metastatic	JJ
cord-000248-zueoyesj	250	13	samples	sample	NNS
cord-000248-zueoyesj	250	14	have	have	VBP
cord-000248-zueoyesj	250	15	a	a	DT
cord-000248-zueoyesj	250	16	large	large	JJ
cord-000248-zueoyesj	250	17	value	value	NN
cord-000248-zueoyesj	250	18	of	of	IN
cord-000248-zueoyesj	250	19	M	m	NN
cord-000248-zueoyesj	250	20	-	-	HYPH
cord-000248-zueoyesj	250	21	skin	skin	NN
cord-000248-zueoyesj	250	22	complexity	complexity	NN
cord-000248-zueoyesj	250	23	,	,	,
cord-000248-zueoyesj	250	24	so	so	CC
cord-000248-zueoyesj	250	25	we	-PRON-	PRP
cord-000248-zueoyesj	250	26	present	present	VBP
cord-000248-zueoyesj	250	27	the	the	DT
cord-000248-zueoyesj	250	28	results	result	NNS
cord-000248-zueoyesj	250	29	of	of	IN
cord-000248-zueoyesj	250	30	another	another	DT
cord-000248-zueoyesj	250	31	experiment	experiment	NN
cord-000248-zueoyesj	250	32	,	,	,
cord-000248-zueoyesj	250	33	aimed	aim	VBN
cord-000248-zueoyesj	250	34	at	at	IN
cord-000248-zueoyesj	250	35	clarifying	clarify	VBG
cord-000248-zueoyesj	250	36	this	this	DT
cord-000248-zueoyesj	250	37	fact	fact	NN
cord-000248-zueoyesj	250	38	.	.	.
cord-000248-zueoyesj	251	1	In	in	IN
cord-000248-zueoyesj	251	2	their	-PRON-	PRP$
cord-000248-zueoyesj	251	3	original	original	JJ
cord-000248-zueoyesj	251	4	publication	publication	NN
cord-000248-zueoyesj	251	5	,	,	,
cord-000248-zueoyesj	251	6	Haqq	Haqq	NNP
cord-000248-zueoyesj	251	7	et	et	NNP
cord-000248-zueoyesj	251	8	al	al	NNP
cord-000248-zueoyesj	251	9	.	.	.
cord-000248-zueoyesj	251	10	classified	classify	VBD
cord-000248-zueoyesj	251	11	the	the	DT
cord-000248-zueoyesj	251	12	melanoma	melanoma	NN
cord-000248-zueoyesj	251	13	metastases	metastasis	NNS
cord-000248-zueoyesj	251	14	in	in	IN
cord-000248-zueoyesj	251	15	two	two	CD
cord-000248-zueoyesj	251	16	groups	group	NNS
cord-000248-zueoyesj	251	17	due	due	JJ
cord-000248-zueoyesj	251	18	to	to	IN
cord-000248-zueoyesj	251	19	their	-PRON-	PRP$
cord-000248-zueoyesj	251	20	molecular	molecular	JJ
cord-000248-zueoyesj	251	21	profiles	profile	NNS
cord-000248-zueoyesj	251	22	:	:	:
cord-000248-zueoyesj	251	23	five	five	CD
cord-000248-zueoyesj	251	24	samples	sample	NNS
cord-000248-zueoyesj	251	25	were	be	VBD
cord-000248-zueoyesj	251	26	classified	classify	VBN
cord-000248-zueoyesj	251	27	as	as	IN
cord-000248-zueoyesj	251	28	'	'	``
cord-000248-zueoyesj	251	29	Type	type	NN
cord-000248-zueoyesj	251	30	I	-PRON-	PRP
cord-000248-zueoyesj	251	31	'	'	''
cord-000248-zueoyesj	251	32	and	and	CC
cord-000248-zueoyesj	251	33	fourteen	fourteen	CD
cord-000248-zueoyesj	251	34	as	as	IN
cord-000248-zueoyesj	251	35	'	'	``
cord-000248-zueoyesj	251	36	Type	type	NN
cord-000248-zueoyesj	251	37	2	2	CD
cord-000248-zueoyesj	251	38	'	'	''
cord-000248-zueoyesj	251	39	based	base	VBN
cord-000248-zueoyesj	251	40	on	on	IN
cord-000248-zueoyesj	251	41	a	a	DT
cord-000248-zueoyesj	251	42	hierarchical	hierarchical	JJ
cord-000248-zueoyesj	251	43	clustering	clustering	NN
cord-000248-zueoyesj	251	44	approach	approach	NN
cord-000248-zueoyesj	251	45	.	.	.
cord-000248-zueoyesj	252	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	252	2	result	result	NN
cord-000248-zueoyesj	252	3	reinforced	reinforce	VBD
cord-000248-zueoyesj	252	4	the	the	DT
cord-000248-zueoyesj	252	5	view	view	NN
cord-000248-zueoyesj	252	6	that	that	IN
cord-000248-zueoyesj	252	7	the	the	DT
cord-000248-zueoyesj	252	8	Type	Type	NNP
cord-000248-zueoyesj	252	9	II	II	NNP
cord-000248-zueoyesj	252	10	melanomas	melanoma	NNS
cord-000248-zueoyesj	252	11	metastasis	metastasis	NN
cord-000248-zueoyesj	252	12	is	be	VBZ
cord-000248-zueoyesj	252	13	a	a	DT
cord-000248-zueoyesj	252	14	pretty	pretty	RB
cord-000248-zueoyesj	252	15	homogeneous	homogeneous	JJ
cord-000248-zueoyesj	252	16	group	group	NN
cord-000248-zueoyesj	252	17	,	,	,
cord-000248-zueoyesj	252	18	we	-PRON-	PRP
cord-000248-zueoyesj	252	19	will	will	MD
cord-000248-zueoyesj	252	20	present	present	VB
cord-000248-zueoyesj	252	21	the	the	DT
cord-000248-zueoyesj	252	22	results	result	NNS
cord-000248-zueoyesj	252	23	on	on	IN
cord-000248-zueoyesj	252	24	the	the	DT
cord-000248-zueoyesj	252	25	(	(	-LRB-
cord-000248-zueoyesj	252	26	Mskin	Mskin	NNP
cord-000248-zueoyesj	252	27	,	,	,
cord-000248-zueoyesj	252	28	M	M	NNP
cord-000248-zueoyesj	252	29	-	-	HYPH
cord-000248-zueoyesj	252	30	metastasis	metastasis	NN
cord-000248-zueoyesj	252	31	I)-plane	I)-plane	NNP
cord-000248-zueoyesj	252	32	.	.	.
cord-000248-zueoyesj	253	1	This	this	DT
cord-000248-zueoyesj	253	2	means	mean	VBZ
cord-000248-zueoyesj	253	3	that	that	IN
cord-000248-zueoyesj	253	4	now	now	RB
cord-000248-zueoyesj	253	5	the	the	DT
cord-000248-zueoyesj	253	6	P	P	NNP
cord-000248-zueoyesj	253	7	ave	ave	NNP
cord-000248-zueoyesj	253	8	profile	profile	NN
cord-000248-zueoyesj	253	9	will	will	MD
cord-000248-zueoyesj	253	10	not	not	RB
cord-000248-zueoyesj	253	11	be	be	VB
cord-000248-zueoyesj	253	12	obtained	obtain	VBN
cord-000248-zueoyesj	253	13	by	by	IN
cord-000248-zueoyesj	253	14	averaging	average	VBG
cord-000248-zueoyesj	253	15	over	over	IN
cord-000248-zueoyesj	253	16	the	the	DT
cord-000248-zueoyesj	253	17	19	19	CD
cord-000248-zueoyesj	253	18	metastases	metastasis	NNS
cord-000248-zueoyesj	253	19	samples	sample	NNS
cord-000248-zueoyesj	253	20	,	,	,
cord-000248-zueoyesj	253	21	but	but	CC
cord-000248-zueoyesj	253	22	instead	instead	RB
cord-000248-zueoyesj	253	23	using	use	VBG
cord-000248-zueoyesj	253	24	only	only	RB
cord-000248-zueoyesj	253	25	the	the	DT
cord-000248-zueoyesj	253	26	14	14	CD
cord-000248-zueoyesj	253	27	samples	sample	NNS
cord-000248-zueoyesj	253	28	which	which	WDT
cord-000248-zueoyesj	253	29	have	have	VBP
cord-000248-zueoyesj	253	30	been	be	VBN
cord-000248-zueoyesj	253	31	labelled	label	VBN
cord-000248-zueoyesj	253	32	as	as	IN
cord-000248-zueoyesj	253	33	'	'	``
cord-000248-zueoyesj	253	34	Type	Type	NNP
cord-000248-zueoyesj	253	35	II	II	NNP
cord-000248-zueoyesj	253	36	'	'	''
cord-000248-zueoyesj	253	37	.	.	.
cord-000248-zueoyesj	254	1	As	as	IN
cord-000248-zueoyesj	254	2	such	such	JJ
cord-000248-zueoyesj	254	3	,	,	,
cord-000248-zueoyesj	254	4	we	-PRON-	PRP
cord-000248-zueoyesj	254	5	aim	aim	VBP
cord-000248-zueoyesj	254	6	at	at	IN
cord-000248-zueoyesj	254	7	revealing	reveal	VBG
cord-000248-zueoyesj	254	8	if	if	IN
cord-000248-zueoyesj	254	9	Type	type	NN
cord-000248-zueoyesj	254	10	I	-PRON-	PRP
cord-000248-zueoyesj	254	11	samples	sample	NNS
cord-000248-zueoyesj	254	12	are	be	VBP
cord-000248-zueoyesj	254	13	indeed	indeed	RB
cord-000248-zueoyesj	254	14	different	different	JJ
cord-000248-zueoyesj	254	15	in	in	IN
cord-000248-zueoyesj	254	16	this	this	DT
cord-000248-zueoyesj	254	17	plane	plane	NN
cord-000248-zueoyesj	254	18	,	,	,
cord-000248-zueoyesj	254	19	and	and	CC
cord-000248-zueoyesj	254	20	if	if	IN
cord-000248-zueoyesj	254	21	other	other	JJ
cord-000248-zueoyesj	254	22	clusters	cluster	NNS
cord-000248-zueoyesj	254	23	are	be	VBP
cord-000248-zueoyesj	254	24	also	also	RB
cord-000248-zueoyesj	254	25	present	present	JJ
cord-000248-zueoyesj	254	26	.	.	.
cord-000248-zueoyesj	255	1	Figure	figure	NN
cord-000248-zueoyesj	255	2	5	5	CD
cord-000248-zueoyesj	255	3	presents	present	VBZ
cord-000248-zueoyesj	255	4	the	the	DT
cord-000248-zueoyesj	255	5	results	result	NNS
cord-000248-zueoyesj	255	6	.	.	.
cord-000248-zueoyesj	256	1	The	the	DT
cord-000248-zueoyesj	256	2	first	first	JJ
cord-000248-zueoyesj	256	3	fact	fact	NN
cord-000248-zueoyesj	256	4	worth	worth	JJ
cord-000248-zueoyesj	256	5	commenting	comment	VBG
cord-000248-zueoyesj	256	6	is	be	VBZ
cord-000248-zueoyesj	256	7	the	the	DT
cord-000248-zueoyesj	256	8	pronounced	pronounced	JJ
cord-000248-zueoyesj	256	9	gap	gap	NN
cord-000248-zueoyesj	256	10	between	between	IN
cord-000248-zueoyesj	256	11	normal	normal	JJ
cord-000248-zueoyesj	256	12	skin	skin	NN
cord-000248-zueoyesj	256	13	samples	sample	NNS
cord-000248-zueoyesj	256	14	and	and	CC
cord-000248-zueoyesj	256	15	the	the	DT
cord-000248-zueoyesj	256	16	nevi	nevus	NNS
cord-000248-zueoyesj	256	17	,	,	,
cord-000248-zueoyesj	256	18	primary	primary	JJ
cord-000248-zueoyesj	256	19	,	,	,
cord-000248-zueoyesj	256	20	and	and	CC
cord-000248-zueoyesj	256	21	metastatic	metastatic	JJ
cord-000248-zueoyesj	256	22	melanoma	melanoma	NN
cord-000248-zueoyesj	256	23	samples	sample	NNS
cord-000248-zueoyesj	256	24	as	as	IN
cord-000248-zueoyesj	256	25	revealed	reveal	VBN
cord-000248-zueoyesj	256	26	by	by	IN
cord-000248-zueoyesj	256	27	the	the	DT
cord-000248-zueoyesj	256	28	Mskin	Mskin	NNP
cord-000248-zueoyesj	256	29	measure	measure	NN
cord-000248-zueoyesj	256	30	.	.	.
cord-000248-zueoyesj	257	1	Note	note	VB
cord-000248-zueoyesj	257	2	also	also	RB
cord-000248-zueoyesj	257	3	that	that	IN
cord-000248-zueoyesj	257	4	the	the	DT
cord-000248-zueoyesj	257	5	M	M	NNP
cord-000248-zueoyesj	257	6	-	-	HYPH
cord-000248-zueoyesj	257	7	skin	skin	NN
cord-000248-zueoyesj	257	8	is	be	VBZ
cord-000248-zueoyesj	257	9	based	base	VBN
cord-000248-zueoyesj	257	10	on	on	IN
cord-000248-zueoyesj	257	11	the	the	DT
cord-000248-zueoyesj	257	12	average	average	JJ
cord-000248-zueoyesj	257	13	profile	profile	NN
cord-000248-zueoyesj	257	14	that	that	DT
cord-000248-zueoyesj	257	15	of	of	IN
cord-000248-zueoyesj	257	16	the	the	DT
cord-000248-zueoyesj	257	17	normal	normal	JJ
cord-000248-zueoyesj	257	18	samples	sample	NNS
cord-000248-zueoyesj	257	19	,	,	,
cord-000248-zueoyesj	257	20	which	which	WDT
cord-000248-zueoyesj	257	21	indicates	indicate	VBZ
cord-000248-zueoyesj	257	22	that	that	IN
cord-000248-zueoyesj	257	23	no	no	DT
cord-000248-zueoyesj	257	24	information	information	NN
cord-000248-zueoyesj	257	25	about	about	IN
cord-000248-zueoyesj	257	26	the	the	DT
cord-000248-zueoyesj	257	27	profiles	profile	NNS
cord-000248-zueoyesj	257	28	of	of	IN
cord-000248-zueoyesj	257	29	metastasis	metastasis	NN
cord-000248-zueoyesj	257	30	are	be	VBP
cord-000248-zueoyesj	257	31	used	use	VBN
cord-000248-zueoyesj	257	32	,	,	,
cord-000248-zueoyesj	257	33	yet	yet	CC
cord-000248-zueoyesj	257	34	M	m	NN
cord-000248-zueoyesj	257	35	-	-	HYPH
cord-000248-zueoyesj	257	36	skin	skin	NN
cord-000248-zueoyesj	257	37	reveals	reveal	VBZ
cord-000248-zueoyesj	257	38	that	that	IN
cord-000248-zueoyesj	257	39	increasing	increase	VBG
cord-000248-zueoyesj	257	40	values	value	NNS
cord-000248-zueoyesj	257	41	of	of	IN
cord-000248-zueoyesj	257	42	this	this	DT
cord-000248-zueoyesj	257	43	measure	measure	NN
cord-000248-zueoyesj	257	44	may	may	MD
cord-000248-zueoyesj	257	45	be	be	VB
cord-000248-zueoyesj	257	46	linked	link	VBN
cord-000248-zueoyesj	257	47	with	with	IN
cord-000248-zueoyesj	257	48	a	a	DT
cord-000248-zueoyesj	257	49	'	'	``
cord-000248-zueoyesj	257	50	progression	progression	NN
cord-000248-zueoyesj	257	51	'	'	''
cord-000248-zueoyesj	257	52	from	from	IN
cord-000248-zueoyesj	257	53	nevi	nevus	NNS
cord-000248-zueoyesj	257	54	to	to	IN
cord-000248-zueoyesj	257	55	primary	primary	JJ
cord-000248-zueoyesj	257	56	and	and	CC
cord-000248-zueoyesj	257	57	metastasis	metastasis	NN
cord-000248-zueoyesj	257	58	melanoma	melanoma	NN
cord-000248-zueoyesj	257	59	profiles	profile	NNS
cord-000248-zueoyesj	257	60	.	.	.
cord-000248-zueoyesj	258	1	We	-PRON-	PRP
cord-000248-zueoyesj	258	2	now	now	RB
cord-000248-zueoyesj	258	3	introduce	introduce	VBP
cord-000248-zueoyesj	258	4	another	another	DT
cord-000248-zueoyesj	258	5	useful	useful	JJ
cord-000248-zueoyesj	258	6	technique	technique	NN
cord-000248-zueoyesj	258	7	to	to	TO
cord-000248-zueoyesj	258	8	identify	identify	VB
cord-000248-zueoyesj	258	9	genes	gene	NNS
cord-000248-zueoyesj	258	10	which	which	WDT
cord-000248-zueoyesj	258	11	correlate	correlate	VBP
cord-000248-zueoyesj	258	12	with	with	IN
cord-000248-zueoyesj	258	13	the	the	DT
cord-000248-zueoyesj	258	14	transitions	transition	NNS
cord-000248-zueoyesj	258	15	.	.	.
cord-000248-zueoyesj	259	1	The	the	DT
cord-000248-zueoyesj	259	2	challenge	challenge	NN
cord-000248-zueoyesj	259	3	is	be	VBZ
cord-000248-zueoyesj	259	4	to	to	TO
cord-000248-zueoyesj	259	5	find	find	VB
cord-000248-zueoyesj	259	6	genes	gene	NNS
cord-000248-zueoyesj	259	7	which	which	WDT
cord-000248-zueoyesj	259	8	are	be	VBP
cord-000248-zueoyesj	259	9	related	relate	VBN
cord-000248-zueoyesj	259	10	with	with	IN
cord-000248-zueoyesj	259	11	the	the	DT
cord-000248-zueoyesj	259	12	progression	progression	NN
cord-000248-zueoyesj	259	13	towards	towards	IN
cord-000248-zueoyesj	259	14	metastases	metastasis	NNS
cord-000248-zueoyesj	259	15	profiles	profile	NNS
cord-000248-zueoyesj	259	16	,	,	,
cord-000248-zueoyesj	259	17	even	even	RB
cord-000248-zueoyesj	259	18	when	when	WRB
cord-000248-zueoyesj	259	19	we	-PRON-	PRP
cord-000248-zueoyesj	259	20	recognize	recognize	VBP
cord-000248-zueoyesj	259	21	that	that	IN
cord-000248-zueoyesj	259	22	there	there	RB
cord-000248-zueoyesj	259	23	the	the	DT
cord-000248-zueoyesj	259	24	group	group	NN
cord-000248-zueoyesj	259	25	of	of	IN
cord-000248-zueoyesj	259	26	metastasis	metastasis	NN
cord-000248-zueoyesj	259	27	samples	sample	NNS
cord-000248-zueoyesj	259	28	is	be	VBZ
cord-000248-zueoyesj	259	29	heterogeneous	heterogeneous	JJ
cord-000248-zueoyesj	259	30	(	(	-LRB-
cord-000248-zueoyesj	259	31	containing	contain	VBG
cord-000248-zueoyesj	259	32	at	at	RB
cord-000248-zueoyesj	259	33	least	least	RBS
cord-000248-zueoyesj	259	34	two	two	CD
cord-000248-zueoyesj	259	35	groups	group	NNS
cord-000248-zueoyesj	259	36	)	)	-RRB-
cord-000248-zueoyesj	259	37	.	.	.
cord-000248-zueoyesj	260	1	Since	since	IN
cord-000248-zueoyesj	260	2	the	the	DT
cord-000248-zueoyesj	260	3	final	final	JJ
cord-000248-zueoyesj	260	4	outcome	outcome	NN
cord-000248-zueoyesj	260	5	of	of	IN
cord-000248-zueoyesj	260	6	Figure	Figure	NNP
cord-000248-zueoyesj	260	7	4	4	CD
cord-000248-zueoyesj	260	8	and	and	CC
cord-000248-zueoyesj	260	9	Figure	Figure	NNP
cord-000248-zueoyesj	260	10	5	5	CD
cord-000248-zueoyesj	260	11	is	be	VBZ
cord-000248-zueoyesj	260	12	that	that	IN
cord-000248-zueoyesj	260	13	the	the	DT
cord-000248-zueoyesj	260	14	Normalized	Normalized	NNP
cord-000248-zueoyesj	260	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	260	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	260	17	does	do	VBZ
cord-000248-zueoyesj	260	18	not	not	RB
cord-000248-zueoyesj	260	19	help	help	VB
cord-000248-zueoyesj	260	20	much	much	JJ
cord-000248-zueoyesj	260	21	in	in	IN
cord-000248-zueoyesj	260	22	this	this	DT
cord-000248-zueoyesj	260	23	experimental	experimental	JJ
cord-000248-zueoyesj	260	24	scenario	scenario	NN
cord-000248-zueoyesj	260	25	,	,	,
cord-000248-zueoyesj	260	26	we	-PRON-	PRP
cord-000248-zueoyesj	260	27	will	will	MD
cord-000248-zueoyesj	260	28	concentrate	concentrate	VB
cord-000248-zueoyesj	260	29	only	only	RB
cord-000248-zueoyesj	260	30	on	on	IN
cord-000248-zueoyesj	260	31	one	one	CD
cord-000248-zueoyesj	260	32	of	of	IN
cord-000248-zueoyesj	260	33	the	the	DT
cord-000248-zueoyesj	260	34	multiplicative	multiplicative	JJ
cord-000248-zueoyesj	260	35	factors	factor	NNS
cord-000248-zueoyesj	260	36	of	of	IN
cord-000248-zueoyesj	260	37	the	the	DT
cord-000248-zueoyesj	260	38	Mcomplexities	Mcomplexities	NNPS
cord-000248-zueoyesj	260	39	,	,	,
cord-000248-zueoyesj	260	40	the	the	DT
cord-000248-zueoyesj	260	41	Jensen	Jensen	NNP
cord-000248-zueoyesj	260	42	-	-	HYPH
cord-000248-zueoyesj	260	43	Shannon	Shannon	NNP
cord-000248-zueoyesj	260	44	divergence	divergence	NN
cord-000248-zueoyesj	260	45	.	.	.
cord-000248-zueoyesj	261	1	We	-PRON-	PRP
cord-000248-zueoyesj	261	2	compute	compute	VBP
cord-000248-zueoyesj	261	3	two	two	CD
cord-000248-zueoyesj	261	4	P	p	NN
cord-000248-zueoyesj	261	5	ave	ave	NNP
cord-000248-zueoyesj	261	6	profiles	profile	NNS
cord-000248-zueoyesj	261	7	,	,	,
cord-000248-zueoyesj	261	8	one	one	CD
cord-000248-zueoyesj	261	9	with	with	IN
cord-000248-zueoyesj	261	10	the	the	DT
cord-000248-zueoyesj	261	11	normal	normal	JJ
cord-000248-zueoyesj	261	12	skin	skin	NN
cord-000248-zueoyesj	261	13	samples	sample	NNS
cord-000248-zueoyesj	261	14	only	only	RB
cord-000248-zueoyesj	261	15	,	,	,
cord-000248-zueoyesj	261	16	and	and	CC
cord-000248-zueoyesj	261	17	the	the	DT
cord-000248-zueoyesj	261	18	other	other	JJ
cord-000248-zueoyesj	261	19	with	with	IN
cord-000248-zueoyesj	261	20	all	all	PDT
cord-000248-zueoyesj	261	21	the	the	DT
cord-000248-zueoyesj	261	22	metastasis	metastasis	NN
cord-000248-zueoyesj	261	23	samples	sample	NNS
cord-000248-zueoyesj	261	24	(	(	-LRB-
cord-000248-zueoyesj	261	25	regardless	regardless	RB
cord-000248-zueoyesj	261	26	their	-PRON-	PRP$
cord-000248-zueoyesj	261	27	type	type	NN
cord-000248-zueoyesj	261	28	)	)	-RRB-
cord-000248-zueoyesj	261	29	.	.	.
cord-000248-zueoyesj	262	1	We	-PRON-	PRP
cord-000248-zueoyesj	262	2	will	will	MD
cord-000248-zueoyesj	262	3	call	call	VB
cord-000248-zueoyesj	262	4	the	the	DT
cord-000248-zueoyesj	262	5	two	two	CD
cord-000248-zueoyesj	262	6	divergences	divergence	NNS
cord-000248-zueoyesj	262	7	JSM0	JSM0	NNP
cord-000248-zueoyesj	262	8	and	and	CC
cord-000248-zueoyesj	262	9	JSM5	JSM5	NNP
cord-000248-zueoyesj	262	10	respectively	respectively	RB
cord-000248-zueoyesj	262	11	.	.	.
cord-000248-zueoyesj	263	1	We	-PRON-	PRP
cord-000248-zueoyesj	263	2	then	then	RB
cord-000248-zueoyesj	263	3	compute	compute	VBP
cord-000248-zueoyesj	263	4	the	the	DT
cord-000248-zueoyesj	263	5	Spearman	Spearman	NNP
cord-000248-zueoyesj	263	6	correlation	correlation	NN
cord-000248-zueoyesj	263	7	of	of	IN
cord-000248-zueoyesj	263	8	the	the	DT
cord-000248-zueoyesj	263	9	profile	profile	NN
cord-000248-zueoyesj	263	10	of	of	IN
cord-000248-zueoyesj	263	11	all	all	DT
cord-000248-zueoyesj	263	12	gene	gene	NN
cord-000248-zueoyesj	263	13	probes	probe	NNS
cord-000248-zueoyesj	263	14	in	in	IN
cord-000248-zueoyesj	263	15	the	the	DT
cord-000248-zueoyesj	263	16	array	array	NN
cord-000248-zueoyesj	263	17	across	across	IN
cord-000248-zueoyesj	263	18	the	the	DT
cord-000248-zueoyesj	263	19	37	37	CD
cord-000248-zueoyesj	263	20	samples	sample	NNS
cord-000248-zueoyesj	263	21	to	to	IN
cord-000248-zueoyesj	263	22	both	both	CC
cord-000248-zueoyesj	263	23	JSM0	JSM0	NNP
cord-000248-zueoyesj	263	24	and	and	CC
cord-000248-zueoyesj	263	25	JSM5	JSM5	NNP
cord-000248-zueoyesj	263	26	.	.	.
cord-000248-zueoyesj	264	1	We	-PRON-	PRP
cord-000248-zueoyesj	264	2	have	have	VBP
cord-000248-zueoyesj	264	3	listed	list	VBN
cord-000248-zueoyesj	264	4	all	all	DT
cord-000248-zueoyesj	264	5	probes	probe	NNS
cord-000248-zueoyesj	264	6	according	accord	VBG
cord-000248-zueoyesj	264	7	to	to	IN
cord-000248-zueoyesj	264	8	the	the	DT
cord-000248-zueoyesj	264	9	absolute	absolute	JJ
cord-000248-zueoyesj	264	10	value	value	NN
cord-000248-zueoyesj	264	11	of	of	IN
cord-000248-zueoyesj	264	12	the	the	DT
cord-000248-zueoyesj	264	13	difference	difference	NN
cord-000248-zueoyesj	264	14	of	of	IN
cord-000248-zueoyesj	264	15	these	these	DT
cord-000248-zueoyesj	264	16	correlations	correlation	NNS
cord-000248-zueoyesj	264	17	,	,	,
cord-000248-zueoyesj	264	18	i.e.	i.e.	FW
cord-000248-zueoyesj	264	19	Abs	abs	NN
cord-000248-zueoyesj	264	20	.	.	.
cord-000248-zueoyesj	265	1	Diff	diff	UH
cord-000248-zueoyesj	265	2	.	.	.
cord-000248-zueoyesj	266	1	(	(	-LRB-
cord-000248-zueoyesj	266	2	probe	probe	NN
cord-000248-zueoyesj	266	3	)	)	-RRB-
cord-000248-zueoyesj	266	4	=	=	NFP
cord-000248-zueoyesj	266	5	|JSM0(probe)2JSM5	|JSM0(probe)2JSM5	NNP
cord-000248-zueoyesj	267	1	(	(	-LRB-
cord-000248-zueoyesj	267	2	probe)|	probe)|	VBN
cord-000248-zueoyesj	267	3	in	in	IN
cord-000248-zueoyesj	267	4	decreasing	decrease	VBG
cord-000248-zueoyesj	267	5	order	order	NN
cord-000248-zueoyesj	267	6	.	.	.
cord-000248-zueoyesj	268	1	The	the	DT
cord-000248-zueoyesj	268	2	results	result	NNS
cord-000248-zueoyesj	268	3	are	be	VBP
cord-000248-zueoyesj	268	4	provided	provide	VBN
cord-000248-zueoyesj	268	5	as	as	IN
cord-000248-zueoyesj	268	6	Haqq-PLoSONE-SupFile.xls	Haqq-PLoSONE-SupFile.xls	NNP
cord-000248-zueoyesj	268	7	,	,	,
cord-000248-zueoyesj	268	8	in	in	IN
cord-000248-zueoyesj	268	9	the	the	DT
cord-000248-zueoyesj	268	10	sheet	sheet	NN
cord-000248-zueoyesj	268	11	labelled	label	VBN
cord-000248-zueoyesj	268	12	'	'	''
cord-000248-zueoyesj	268	13	Results	result	NNS
cord-000248-zueoyesj	268	14	-	-	HYPH
cord-000248-zueoyesj	268	15	correlation	correlation	NN
cord-000248-zueoyesj	268	16	'	'	''
cord-000248-zueoyesj	268	17	.	.	.
cord-000248-zueoyesj	269	1	The	the	DT
cord-000248-zueoyesj	269	2	rationale	rationale	NN
cord-000248-zueoyesj	269	3	is	be	VBZ
cord-000248-zueoyesj	269	4	to	to	TO
cord-000248-zueoyesj	269	5	identify	identify	VB
cord-000248-zueoyesj	269	6	those	those	DT
cord-000248-zueoyesj	269	7	probes	probe	NNS
cord-000248-zueoyesj	269	8	which	which	WDT
cord-000248-zueoyesj	269	9	are	be	VBP
cord-000248-zueoyesj	269	10	highly	highly	RB
cord-000248-zueoyesj	269	11	correlated	correlate	VBN
cord-000248-zueoyesj	269	12	(	(	-LRB-
cord-000248-zueoyesj	269	13	both	both	CC
cord-000248-zueoyesj	269	14	positively	positively	RB
cord-000248-zueoyesj	269	15	or	or	CC
cord-000248-zueoyesj	269	16	negatively	negatively	RB
cord-000248-zueoyesj	269	17	)	)	-RRB-
cord-000248-zueoyesj	269	18	with	with	IN
cord-000248-zueoyesj	269	19	the	the	DT
cord-000248-zueoyesj	269	20	Jensen	Jensen	NNP
cord-000248-zueoyesj	269	21	-	-	HYPH
cord-000248-zueoyesj	269	22	Shannon	Shannon	NNP
cord-000248-zueoyesj	269	23	divergence	divergence	NN
cord-000248-zueoyesj	269	24	of	of	IN
cord-000248-zueoyesj	269	25	the	the	DT
cord-000248-zueoyesj	269	26	normal	normal	JJ
cord-000248-zueoyesj	269	27	tissue	tissue	NN
cord-000248-zueoyesj	269	28	profile	profile	NN
cord-000248-zueoyesj	269	29	and	and	CC
cord-000248-zueoyesj	269	30	that	that	IN
cord-000248-zueoyesj	269	31	'	'	''
cord-000248-zueoyesj	269	32	'	'	``
cord-000248-zueoyesj	269	33	reverse	reverse	NN
cord-000248-zueoyesj	269	34	signs	sign	NNS
cord-000248-zueoyesj	269	35	'	'	''
cord-000248-zueoyesj	269	36	'	'	''
cord-000248-zueoyesj	269	37	.	.	.
cord-000248-zueoyesj	270	1	For	for	IN
cord-000248-zueoyesj	270	2	instance	instance	NN
cord-000248-zueoyesj	270	3	,	,	,
cord-000248-zueoyesj	270	4	a	a	DT
cord-000248-zueoyesj	270	5	probe	probe	NN
cord-000248-zueoyesj	270	6	for	for	IN
cord-000248-zueoyesj	270	7	the	the	DT
cord-000248-zueoyesj	270	8	TP63	TP63	NNP
cord-000248-zueoyesj	270	9	gene	gene	NN
cord-000248-zueoyesj	270	10	(	(	-LRB-
cord-000248-zueoyesj	270	11	Tumor	tumor	NN
cord-000248-zueoyesj	270	12	protein	protein	NN
cord-000248-zueoyesj	270	13	p63	p63	NN
cord-000248-zueoyesj	270	14	,	,	,
cord-000248-zueoyesj	270	15	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	270	16	transcription	transcription	NN
cord-000248-zueoyesj	270	17	factor	factor	NN
cord-000248-zueoyesj	270	18	KET	KET	NNP
cord-000248-zueoyesj	270	19	)	)	-RRB-
cord-000248-zueoyesj	270	20	,	,	,
cord-000248-zueoyesj	270	21	AA455929	aa455929	NN
cord-000248-zueoyesj	270	22	,	,	,
cord-000248-zueoyesj	270	23	is	be	VBZ
cord-000248-zueoyesj	270	24	ranked	rank	VBN
cord-000248-zueoyesj	270	25	in	in	IN
cord-000248-zueoyesj	270	26	the	the	DT
cord-000248-zueoyesj	270	27	third	third	JJ
cord-000248-zueoyesj	270	28	position	position	NN
cord-000248-zueoyesj	270	29	.	.	.
cord-000248-zueoyesj	271	1	Its	-PRON-	PRP$
cord-000248-zueoyesj	271	2	correlation	correlation	NN
cord-000248-zueoyesj	271	3	with	with	IN
cord-000248-zueoyesj	271	4	the	the	DT
cord-000248-zueoyesj	271	5	Jensen	Jensen	NNP
cord-000248-zueoyesj	271	6	-	-	HYPH
cord-000248-zueoyesj	271	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	271	8	divergence	divergence	NN
cord-000248-zueoyesj	271	9	of	of	IN
cord-000248-zueoyesj	271	10	the	the	DT
cord-000248-zueoyesj	271	11	normal	normal	JJ
cord-000248-zueoyesj	271	12	skin	skin	NN
cord-000248-zueoyesj	271	13	type	type	NN
cord-000248-zueoyesj	271	14	is	be	VBZ
cord-000248-zueoyesj	271	15	relatively	relatively	RB
cord-000248-zueoyesj	271	16	high	high	JJ
cord-000248-zueoyesj	271	17	and	and	CC
cord-000248-zueoyesj	271	18	negative	negative	JJ
cord-000248-zueoyesj	272	1	(	(	-LRB-
cord-000248-zueoyesj	272	2	JSM0	JSM0	NNP
cord-000248-zueoyesj	272	3	=	=	SYM
cord-000248-zueoyesj	272	4	20.63632	20.63632	CD
cord-000248-zueoyesj	272	5	)	)	-RRB-
cord-000248-zueoyesj	273	1	while	while	IN
cord-000248-zueoyesj	273	2	at	at	IN
cord-000248-zueoyesj	273	3	the	the	DT
cord-000248-zueoyesj	273	4	same	same	JJ
cord-000248-zueoyesj	273	5	time	time	NN
cord-000248-zueoyesj	273	6	is	be	VBZ
cord-000248-zueoyesj	273	7	has	have	VBZ
cord-000248-zueoyesj	273	8	a	a	DT
cord-000248-zueoyesj	273	9	positive	positive	JJ
cord-000248-zueoyesj	273	10	correlation	correlation	NN
cord-000248-zueoyesj	273	11	with	with	IN
cord-000248-zueoyesj	273	12	the	the	DT
cord-000248-zueoyesj	273	13	Jensen	Jensen	NNP
cord-000248-zueoyesj	273	14	-	-	HYPH
cord-000248-zueoyesj	273	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	273	16	divergence	divergence	NN
cord-000248-zueoyesj	273	17	of	of	IN
cord-000248-zueoyesj	273	18	the	the	DT
cord-000248-zueoyesj	273	19	metastasis	metastasis	NN
cord-000248-zueoyesj	273	20	profile	profile	NN
cord-000248-zueoyesj	273	21	(	(	-LRB-
cord-000248-zueoyesj	273	22	JSM5	JSM5	NNP
cord-000248-zueoyesj	273	23	=	=	SYM
cord-000248-zueoyesj	273	24	0.62138	0.62138	CD
cord-000248-zueoyesj	273	25	)	)	-RRB-
cord-000248-zueoyesj	273	26	.	.	.
cord-000248-zueoyesj	274	1	In	in	IN
cord-000248-zueoyesj	274	2	the	the	DT
cord-000248-zueoyesj	274	3	ranking	ranking	NN
cord-000248-zueoyesj	274	4	,	,	,
cord-000248-zueoyesj	274	5	the	the	DT
cord-000248-zueoyesj	274	6	first	first	JJ
cord-000248-zueoyesj	274	7	probe	probe	NN
cord-000248-zueoyesj	274	8	that	that	WDT
cord-000248-zueoyesj	274	9	presents	present	VBZ
cord-000248-zueoyesj	274	10	the	the	DT
cord-000248-zueoyesj	274	11	opposite	opposite	JJ
cord-000248-zueoyesj	274	12	behaviour	behaviour	NN
cord-000248-zueoyesj	274	13	is	be	VBZ
cord-000248-zueoyesj	274	14	one	one	CD
cord-000248-zueoyesj	274	15	for	for	IN
cord-000248-zueoyesj	274	16	ADA	ADA	NNP
cord-000248-zueoyesj	274	17	(	(	-LRB-
cord-000248-zueoyesj	274	18	Adenosine	adenosine	NN
cord-000248-zueoyesj	274	19	deaminase	deaminase	NNP
cord-000248-zueoyesj	274	20	)	)	-RRB-
cord-000248-zueoyesj	274	21	,	,	,
cord-000248-zueoyesj	274	22	AA683578	aa683578	NN
cord-000248-zueoyesj	274	23	.	.	.
cord-000248-zueoyesj	275	1	Figure	figure	NN
cord-000248-zueoyesj	275	2	6	6	CD
cord-000248-zueoyesj	275	3	helps	help	VBZ
cord-000248-zueoyesj	275	4	to	to	TO
cord-000248-zueoyesj	275	5	understand	understand	VB
cord-000248-zueoyesj	275	6	the	the	DT
cord-000248-zueoyesj	275	7	relationship	relationship	NN
cord-000248-zueoyesj	275	8	of	of	IN
cord-000248-zueoyesj	275	9	these	these	DT
cord-000248-zueoyesj	275	10	correlations	correlation	NNS
cord-000248-zueoyesj	275	11	with	with	IN
cord-000248-zueoyesj	275	12	expression	expression	NN
cord-000248-zueoyesj	275	13	.	.	.
cord-000248-zueoyesj	276	1	Not	not	RB
cord-000248-zueoyesj	276	2	only	only	RB
cord-000248-zueoyesj	276	3	are	be	VBP
cord-000248-zueoyesj	276	4	these	these	DT
cord-000248-zueoyesj	276	5	genes	gene	NNS
cord-000248-zueoyesj	276	6	well	well	RB
cord-000248-zueoyesj	276	7	correlated	correlate	VBN
cord-000248-zueoyesj	276	8	with	with	IN
cord-000248-zueoyesj	276	9	the	the	DT
cord-000248-zueoyesj	276	10	divergences	divergence	NNS
cord-000248-zueoyesj	276	11	,	,	,
cord-000248-zueoyesj	276	12	they	-PRON-	PRP
cord-000248-zueoyesj	276	13	also	also	RB
cord-000248-zueoyesj	276	14	seem	seem	VBP
cord-000248-zueoyesj	276	15	to	to	TO
cord-000248-zueoyesj	276	16	be	be	VB
cord-000248-zueoyesj	276	17	good	good	JJ
cord-000248-zueoyesj	276	18	markers	marker	NNS
cord-000248-zueoyesj	276	19	of	of	IN
cord-000248-zueoyesj	276	20	the	the	DT
cord-000248-zueoyesj	276	21	progression	progression	NN
cord-000248-zueoyesj	276	22	from	from	IN
cord-000248-zueoyesj	276	23	one	one	CD
cord-000248-zueoyesj	276	24	tissue	tissue	NN
cord-000248-zueoyesj	276	25	type	type	NN
cord-000248-zueoyesj	276	26	profile	profile	NN
cord-000248-zueoyesj	276	27	to	to	IN
cord-000248-zueoyesj	276	28	the	the	DT
cord-000248-zueoyesj	276	29	metastasis	metastasis	NN
cord-000248-zueoyesj	276	30	profile	profile	NN
cord-000248-zueoyesj	276	31	.	.	.
cord-000248-zueoyesj	277	1	We	-PRON-	PRP
cord-000248-zueoyesj	277	2	will	will	MD
cord-000248-zueoyesj	277	3	now	now	RB
cord-000248-zueoyesj	277	4	discuss	discuss	VB
cord-000248-zueoyesj	277	5	three	three	CD
cord-000248-zueoyesj	277	6	of	of	IN
cord-000248-zueoyesj	277	7	these	these	DT
cord-000248-zueoyesj	277	8	genes	gene	NNS
cord-000248-zueoyesj	277	9	in	in	IN
cord-000248-zueoyesj	277	10	the	the	DT
cord-000248-zueoyesj	277	11	context	context	NN
cord-000248-zueoyesj	277	12	of	of	IN
cord-000248-zueoyesj	277	13	current	current	JJ
cord-000248-zueoyesj	277	14	biological	biological	JJ
cord-000248-zueoyesj	277	15	knowledge	knowledge	NN
cord-000248-zueoyesj	277	16	on	on	IN
cord-000248-zueoyesj	277	17	melanoma	melanoma	NN
cord-000248-zueoyesj	277	18	drivers	driver	NNS
cord-000248-zueoyesj	277	19	and	and	CC
cord-000248-zueoyesj	277	20	metastatic	metastatic	JJ
cord-000248-zueoyesj	277	21	progression	progression	NN
cord-000248-zueoyesj	277	22	.	.	.
cord-000248-zueoyesj	278	1	We	-PRON-	PRP
cord-000248-zueoyesj	278	2	provide	provide	VBP
cord-000248-zueoyesj	278	3	many	many	JJ
cord-000248-zueoyesj	278	4	references	reference	NNS
cord-000248-zueoyesj	278	5	for	for	IN
cord-000248-zueoyesj	278	6	one	one	CD
cord-000248-zueoyesj	278	7	of	of	IN
cord-000248-zueoyesj	278	8	them	-PRON-	PRP
cord-000248-zueoyesj	278	9	,	,	,
cord-000248-zueoyesj	278	10	SPP1	SPP1	NNP
cord-000248-zueoyesj	278	11	(	(	-LRB-
cord-000248-zueoyesj	278	12	Secreted	secreted	NN
cord-000248-zueoyesj	278	13	phosphoprotein	phosphoprotein	NN
cord-000248-zueoyesj	278	14	1	1	CD
cord-000248-zueoyesj	278	15	or	or	CC
cord-000248-zueoyesj	278	16	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	278	17	)	)	-RRB-
cord-000248-zueoyesj	278	18	.	.	.
cord-000248-zueoyesj	279	1	The	the	DT
cord-000248-zueoyesj	279	2	discussion	discussion	NN
cord-000248-zueoyesj	279	3	on	on	IN
cord-000248-zueoyesj	279	4	this	this	DT
cord-000248-zueoyesj	279	5	gene	gene	NN
cord-000248-zueoyesj	279	6	will	will	MD
cord-000248-zueoyesj	279	7	be	be	VB
cord-000248-zueoyesj	279	8	left	leave	VBN
cord-000248-zueoyesj	279	9	for	for	IN
cord-000248-zueoyesj	279	10	later	later	RBR
cord-000248-zueoyesj	279	11	,	,	,
cord-000248-zueoyesj	279	12	when	when	WRB
cord-000248-zueoyesj	279	13	we	-PRON-	PRP
cord-000248-zueoyesj	279	14	will	will	MD
cord-000248-zueoyesj	279	15	discuss	discuss	VB
cord-000248-zueoyesj	279	16	specifc	specifc	JJ
cord-000248-zueoyesj	279	17	oncosystems	oncosystem	NNS
cord-000248-zueoyesj	279	18	related	relate	VBN
cord-000248-zueoyesj	279	19	to	to	IN
cord-000248-zueoyesj	279	20	cell	cell	NN
cord-000248-zueoyesj	279	21	proliferation	proliferation	NN
cord-000248-zueoyesj	279	22	,	,	,
cord-000248-zueoyesj	279	23	chemotaxis	chemotaxis	NN
cord-000248-zueoyesj	279	24	and	and	CC
cord-000248-zueoyesj	279	25	responses	response	NNS
cord-000248-zueoyesj	279	26	to	to	IN
cord-000248-zueoyesj	279	27	external	external	JJ
cord-000248-zueoyesj	279	28	simulus	simulus	NN
cord-000248-zueoyesj	279	29	.	.	.
cord-000248-zueoyesj	280	1	Figure	figure	NN
cord-000248-zueoyesj	280	2	7	7	CD
cord-000248-zueoyesj	280	3	shows	show	VBZ
cord-000248-zueoyesj	280	4	the	the	DT
cord-000248-zueoyesj	280	5	expression	expression	NN
cord-000248-zueoyesj	280	6	of	of	IN
cord-000248-zueoyesj	280	7	ADA	ADA	NNP
cord-000248-zueoyesj	280	8	(	(	-LRB-
cord-000248-zueoyesj	280	9	Adenosine	adenosine	NN
cord-000248-zueoyesj	280	10	deaminase	deaminase	NN
cord-000248-zueoyesj	280	11	,	,	,
cord-000248-zueoyesj	280	12	AA683578	aa683578	NN
cord-000248-zueoyesj	280	13	)	)	-RRB-
cord-000248-zueoyesj	280	14	as	as	IN
cord-000248-zueoyesj	280	15	a	a	DT
cord-000248-zueoyesj	280	16	function	function	NN
cord-000248-zueoyesj	280	17	of	of	IN
cord-000248-zueoyesj	280	18	TP63	TP63	NNP
cord-000248-zueoyesj	280	19	(	(	-LRB-
cord-000248-zueoyesj	280	20	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	280	21	transcription	transcription	NN
cord-000248-zueoyesj	280	22	factor	factor	NN
cord-000248-zueoyesj	280	23	KET	KET	NNP
cord-000248-zueoyesj	280	24	,	,	,
cord-000248-zueoyesj	280	25	AA455929	aa455929	NN
cord-000248-zueoyesj	280	26	)	)	-RRB-
cord-000248-zueoyesj	280	27	.	.	.
cord-000248-zueoyesj	281	1	All	all	DT
cord-000248-zueoyesj	281	2	normal	normal	JJ
cord-000248-zueoyesj	281	3	skin	skin	NN
cord-000248-zueoyesj	281	4	samples	sample	NNS
cord-000248-zueoyesj	281	5	,	,	,
cord-000248-zueoyesj	281	6	as	as	RB
cord-000248-zueoyesj	281	7	well	well	RB
cord-000248-zueoyesj	281	8	as	as	IN
cord-000248-zueoyesj	281	9	nevi	nevus	NNS
cord-000248-zueoyesj	281	10	and	and	CC
cord-000248-zueoyesj	281	11	a	a	DT
cord-000248-zueoyesj	281	12	couple	couple	NN
cord-000248-zueoyesj	281	13	of	of	IN
cord-000248-zueoyesj	281	14	primary	primary	JJ
cord-000248-zueoyesj	281	15	melanomas	melanoma	NNS
cord-000248-zueoyesj	281	16	have	have	VBP
cord-000248-zueoyesj	281	17	relatively	relatively	RB
cord-000248-zueoyesj	281	18	low	low	JJ
cord-000248-zueoyesj	281	19	values	value	NNS
cord-000248-zueoyesj	281	20	of	of	IN
cord-000248-zueoyesj	281	21	ADA	ADA	NNP
cord-000248-zueoyesj	281	22	but	but	CC
cord-000248-zueoyesj	281	23	they	-PRON-	PRP
cord-000248-zueoyesj	281	24	express	express	VBP
cord-000248-zueoyesj	281	25	TP63	TP63	NNP
cord-000248-zueoyesj	281	26	.	.	.
cord-000248-zueoyesj	282	1	There	there	EX
cord-000248-zueoyesj	282	2	is	be	VBZ
cord-000248-zueoyesj	282	3	a	a	DT
cord-000248-zueoyesj	282	4	change	change	NN
cord-000248-zueoyesj	282	5	of	of	IN
cord-000248-zueoyesj	282	6	roles	role	NNS
cord-000248-zueoyesj	282	7	in	in	IN
cord-000248-zueoyesj	282	8	metastatic	metastatic	JJ
cord-000248-zueoyesj	282	9	and	and	CC
cord-000248-zueoyesj	282	10	some	some	DT
cord-000248-zueoyesj	282	11	primary	primary	JJ
cord-000248-zueoyesj	282	12	melanomas	melanoma	NNS
cord-000248-zueoyesj	282	13	,	,	,
cord-000248-zueoyesj	282	14	which	which	WDT
cord-000248-zueoyesj	282	15	have	have	VBP
cord-000248-zueoyesj	282	16	reduced	reduce	VBN
cord-000248-zueoyesj	282	17	TP63	TP63	NNP
cord-000248-zueoyesj	282	18	expression	expression	NN
cord-000248-zueoyesj	282	19	but	but	CC
cord-000248-zueoyesj	282	20	increased	increase	VBN
cord-000248-zueoyesj	282	21	values	value	NNS
cord-000248-zueoyesj	282	22	of	of	IN
cord-000248-zueoyesj	282	23	expression	expression	NN
cord-000248-zueoyesj	282	24	of	of	IN
cord-000248-zueoyesj	282	25	ADA	ADA	NNP
cord-000248-zueoyesj	282	26	.	.	.
cord-000248-zueoyesj	283	1	As	as	IN
cord-000248-zueoyesj	283	2	we	-PRON-	PRP
cord-000248-zueoyesj	283	3	will	will	MD
cord-000248-zueoyesj	283	4	later	later	RB
cord-000248-zueoyesj	283	5	see	see	VB
cord-000248-zueoyesj	283	6	,	,	,
cord-000248-zueoyesj	283	7	these	these	DT
cord-000248-zueoyesj	283	8	events	event	NNS
cord-000248-zueoyesj	283	9	correlate	correlate	VBP
cord-000248-zueoyesj	283	10	with	with	IN
cord-000248-zueoyesj	283	11	other	other	JJ
cord-000248-zueoyesj	283	12	major	major	JJ
cord-000248-zueoyesj	283	13	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	283	14	modifications	modification	NNS
cord-000248-zueoyesj	283	15	which	which	WDT
cord-000248-zueoyesj	283	16	involve	involve	VBP
cord-000248-zueoyesj	283	17	dozens	dozen	NNS
cord-000248-zueoyesj	283	18	of	of	IN
cord-000248-zueoyesj	283	19	genes	gene	NNS
cord-000248-zueoyesj	283	20	and	and	CC
cord-000248-zueoyesj	283	21	that	that	IN
cord-000248-zueoyesj	283	22	we	-PRON-	PRP
cord-000248-zueoyesj	283	23	have	have	VBP
cord-000248-zueoyesj	283	24	been	be	VBN
cord-000248-zueoyesj	283	25	able	able	JJ
cord-000248-zueoyesj	283	26	to	to	TO
cord-000248-zueoyesj	283	27	map	map	VB
cord-000248-zueoyesj	283	28	thanks	thank	NNS
cord-000248-zueoyesj	283	29	to	to	IN
cord-000248-zueoyesj	283	30	functional	functional	JJ
cord-000248-zueoyesj	283	31	genomics	genomic	NNS
cord-000248-zueoyesj	283	32	bioinformatics	bioinformatics	NN
cord-000248-zueoyesj	283	33	tools	tool	NNS
cord-000248-zueoyesj	283	34	.	.	.
cord-000248-zueoyesj	284	1	The	the	DT
cord-000248-zueoyesj	284	2	role	role	NN
cord-000248-zueoyesj	284	3	of	of	IN
cord-000248-zueoyesj	284	4	SPP1	SPP1	NNP
cord-000248-zueoyesj	284	5	will	will	MD
cord-000248-zueoyesj	284	6	be	be	VB
cord-000248-zueoyesj	284	7	discussed	discuss	VBN
cord-000248-zueoyesj	284	8	in	in	IN
cord-000248-zueoyesj	284	9	that	that	DT
cord-000248-zueoyesj	284	10	context	context	NN
cord-000248-zueoyesj	284	11	after	after	IN
cord-000248-zueoyesj	284	12	some	some	DT
cord-000248-zueoyesj	284	13	references	reference	NNS
cord-000248-zueoyesj	284	14	to	to	IN
cord-000248-zueoyesj	284	15	TP63	TP63	NNP
cord-000248-zueoyesj	284	16	,	,	,
cord-000248-zueoyesj	284	17	ADA	ADA	NNP
cord-000248-zueoyesj	284	18	,	,	,
cord-000248-zueoyesj	284	19	and	and	CC
cord-000248-zueoyesj	284	20	PLK1	PLK1	NNP
cord-000248-zueoyesj	284	21	which	which	WDT
cord-000248-zueoyesj	284	22	follow	follow	VBP
cord-000248-zueoyesj	284	23	.	.	.
cord-000248-zueoyesj	285	1	TP63	TP63	NNP
cord-000248-zueoyesj	285	2	.	.	.
cord-000248-zueoyesj	286	1	The	the	DT
cord-000248-zueoyesj	286	2	product	product	NN
cord-000248-zueoyesj	286	3	of	of	IN
cord-000248-zueoyesj	286	4	this	this	DT
cord-000248-zueoyesj	286	5	gene	gene	NN
cord-000248-zueoyesj	286	6	[	[	-LRB-
cord-000248-zueoyesj	286	7	111	111	CD
cord-000248-zueoyesj	286	8	,	,	,
cord-000248-zueoyesj	286	9	112	112	CD
cord-000248-zueoyesj	286	10	]	]	-RRB-
cord-000248-zueoyesj	286	11	belongs	belong	VBZ
cord-000248-zueoyesj	286	12	to	to	IN
cord-000248-zueoyesj	286	13	the	the	DT
cord-000248-zueoyesj	286	14	same	same	JJ
cord-000248-zueoyesj	286	15	protein	protein	NN
cord-000248-zueoyesj	286	16	family	family	NN
cord-000248-zueoyesj	286	17	of	of	IN
cord-000248-zueoyesj	286	18	its	-PRON-	PRP$
cord-000248-zueoyesj	286	19	more	more	RBR
cord-000248-zueoyesj	286	20	famous	famous	JJ
cord-000248-zueoyesj	286	21	relative	relative	NN
cord-000248-zueoyesj	286	22	,	,	,
cord-000248-zueoyesj	286	23	TP53	TP53	NNP
cord-000248-zueoyesj	286	24	,	,	,
cord-000248-zueoyesj	286	25	a	a	DT
cord-000248-zueoyesj	286	26	gene	gene	NN
cord-000248-zueoyesj	286	27	that	that	WDT
cord-000248-zueoyesj	286	28	is	be	VBZ
cord-000248-zueoyesj	286	29	often	often	RB
cord-000248-zueoyesj	286	30	mutated	mutate	VBN
cord-000248-zueoyesj	286	31	in	in	IN
cord-000248-zueoyesj	286	32	human	human	JJ
cord-000248-zueoyesj	286	33	cancers	cancer	NNS
cord-000248-zueoyesj	286	34	[	[	-LRB-
cord-000248-zueoyesj	286	35	113	113	CD
cord-000248-zueoyesj	286	36	]	]	-RRB-
cord-000248-zueoyesj	286	37	and	and	CC
cord-000248-zueoyesj	286	38	highly	highly	RB
cord-000248-zueoyesj	286	39	regarded	regard	VBN
cord-000248-zueoyesj	286	40	as	as	IN
cord-000248-zueoyesj	286	41	a	a	DT
cord-000248-zueoyesj	286	42	key	key	NN
cord-000248-zueoyesj	286	43	'	'	''
cord-000248-zueoyesj	286	44	'	'	``
cord-000248-zueoyesj	286	45	tumor	tumor	NN
cord-000248-zueoyesj	286	46	suppressor	suppressor	NN
cord-000248-zueoyesj	286	47	'	'	''
cord-000248-zueoyesj	286	48	'	'	''
cord-000248-zueoyesj	286	49	.	.	.
cord-000248-zueoyesj	287	1	TP63	TP63	NNP
cord-000248-zueoyesj	287	2	's	's	POS
cord-000248-zueoyesj	287	3	product	product	NN
cord-000248-zueoyesj	287	4	,	,	,
cord-000248-zueoyesj	287	5	p63	p63	CD
cord-000248-zueoyesj	287	6	,	,	,
cord-000248-zueoyesj	287	7	is	be	VBZ
cord-000248-zueoyesj	287	8	a	a	DT
cord-000248-zueoyesj	287	9	homologous	homologous	JJ
cord-000248-zueoyesj	287	10	protein	protein	NN
cord-000248-zueoyesj	287	11	to	to	IN
cord-000248-zueoyesj	287	12	p53	p53	NN
cord-000248-zueoyesj	287	13	,	,	,
cord-000248-zueoyesj	287	14	which	which	WDT
cord-000248-zueoyesj	287	15	is	be	VBZ
cord-000248-zueoyesj	287	16	considered	consider	VBN
cord-000248-zueoyesj	287	17	to	to	TO
cord-000248-zueoyesj	287	18	be	be	VB
cord-000248-zueoyesj	287	19	phylogenetically	phylogenetically	RB
cord-000248-zueoyesj	287	20	newer	new	JJR
cord-000248-zueoyesj	287	21	[	[	-LRB-
cord-000248-zueoyesj	287	22	114	114	CD
cord-000248-zueoyesj	287	23	]	]	-RRB-
cord-000248-zueoyesj	287	24	and	and	CC
cord-000248-zueoyesj	287	25	also	also	RB
cord-000248-zueoyesj	287	26	regarded	regard	VBN
cord-000248-zueoyesj	287	27	as	as	IN
cord-000248-zueoyesj	287	28	an	an	DT
cord-000248-zueoyesj	287	29	important	important	JJ
cord-000248-zueoyesj	287	30	apoptotic	apoptotic	JJ
cord-000248-zueoyesj	287	31	and	and	CC
cord-000248-zueoyesj	287	32	cell	cell	NN
cord-000248-zueoyesj	287	33	-	-	HYPH
cord-000248-zueoyesj	287	34	cycle	cycle	NN
cord-000248-zueoyesj	287	35	arrest	arrest	NN
cord-000248-zueoyesj	287	36	protein	protein	NN
cord-000248-zueoyesj	287	37	.	.	.
cord-000248-zueoyesj	288	1	Mice	mouse	NNS
cord-000248-zueoyesj	288	2	that	that	WDT
cord-000248-zueoyesj	288	3	lack	lack	VBP
cord-000248-zueoyesj	289	1	TP53	TP53	NNS
cord-000248-zueoyesj	289	2	are	be	VBP
cord-000248-zueoyesj	289	3	born	bear	VBN
cord-000248-zueoyesj	289	4	alive	alive	JJ
cord-000248-zueoyesj	289	5	with	with	IN
cord-000248-zueoyesj	289	6	a	a	DT
cord-000248-zueoyesj	289	7	propensity	propensity	NN
cord-000248-zueoyesj	289	8	for	for	IN
cord-000248-zueoyesj	289	9	developing	develop	VBG
cord-000248-zueoyesj	289	10	tumours	tumour	NNS
cord-000248-zueoyesj	289	11	;	;	:
cord-000248-zueoyesj	289	12	mice	mouse	NNS
cord-000248-zueoyesj	289	13	that	that	WDT
cord-000248-zueoyesj	289	14	lack	lack	VBP
cord-000248-zueoyesj	289	15	TP63	TP63	NNP
cord-000248-zueoyesj	289	16	do	do	VBP
cord-000248-zueoyesj	289	17	not	not	RB
cord-000248-zueoyesj	289	18	appear	appear	VB
cord-000248-zueoyesj	289	19	to	to	TO
cord-000248-zueoyesj	289	20	be	be	VB
cord-000248-zueoyesj	289	21	tumour	tumour	NN
cord-000248-zueoyesj	289	22	prone	prone	JJ
cord-000248-zueoyesj	289	23	,	,	,
cord-000248-zueoyesj	289	24	although	although	IN
cord-000248-zueoyesj	289	25	,	,	,
cord-000248-zueoyesj	289	26	new	new	JJ
cord-000248-zueoyesj	289	27	results	result	NNS
cord-000248-zueoyesj	289	28	are	be	VBP
cord-000248-zueoyesj	289	29	partially	partially	RB
cord-000248-zueoyesj	289	30	contradicting	contradict	VBG
cord-000248-zueoyesj	289	31	earlier	early	JJR
cord-000248-zueoyesj	289	32	findings	finding	NNS
cord-000248-zueoyesj	289	33	[	[	-LRB-
cord-000248-zueoyesj	289	34	115	115	CD
cord-000248-zueoyesj	289	35	]	]	-RRB-
cord-000248-zueoyesj	289	36	.	.	.
cord-000248-zueoyesj	290	1	It	-PRON-	PRP
cord-000248-zueoyesj	290	2	appears	appear	VBZ
cord-000248-zueoyesj	290	3	that	that	IN
cord-000248-zueoyesj	290	4	the	the	DT
cord-000248-zueoyesj	290	5	diverse	diverse	JJ
cord-000248-zueoyesj	290	6	roles	role	NNS
cord-000248-zueoyesj	290	7	of	of	IN
cord-000248-zueoyesj	290	8	the	the	DT
cord-000248-zueoyesj	290	9	isoforms	isoform	NNS
cord-000248-zueoyesj	290	10	of	of	IN
cord-000248-zueoyesj	290	11	the	the	DT
cord-000248-zueoyesj	290	12	p63	p63	NNP
cord-000248-zueoyesj	290	13	family	family	NN
cord-000248-zueoyesj	290	14	reveal	reveal	VBP
cord-000248-zueoyesj	290	15	that	that	IN
cord-000248-zueoyesj	290	16	there	there	EX
cord-000248-zueoyesj	290	17	exists	exist	VBZ
cord-000248-zueoyesj	290	18	a	a	DT
cord-000248-zueoyesj	290	19	crosstalk	crosstalk	NN
cord-000248-zueoyesj	290	20	with	with	IN
cord-000248-zueoyesj	290	21	the	the	DT
cord-000248-zueoyesj	290	22	different	different	JJ
cord-000248-zueoyesj	290	23	isoforms	isoform	NNS
cord-000248-zueoyesj	290	24	of	of	IN
cord-000248-zueoyesj	290	25	the	the	DT
cord-000248-zueoyesj	290	26	p53	p53	NN
cord-000248-zueoyesj	290	27	family	family	NN
cord-000248-zueoyesj	290	28	that	that	WDT
cord-000248-zueoyesj	290	29	needs	need	VBZ
cord-000248-zueoyesj	290	30	to	to	TO
cord-000248-zueoyesj	290	31	be	be	VB
cord-000248-zueoyesj	290	32	systematically	systematically	RB
cord-000248-zueoyesj	290	33	investigated	investigate	VBN
cord-000248-zueoyesj	290	34	[	[	-LRB-
cord-000248-zueoyesj	290	35	116	116	CD
cord-000248-zueoyesj	290	36	]	]	-RRB-
cord-000248-zueoyesj	290	37	.	.	.
cord-000248-zueoyesj	291	1	It	-PRON-	PRP
cord-000248-zueoyesj	291	2	has	have	VBZ
cord-000248-zueoyesj	291	3	recently	recently	RB
cord-000248-zueoyesj	291	4	been	be	VBN
cord-000248-zueoyesj	291	5	shown	show	VBN
cord-000248-zueoyesj	291	6	that	that	IN
cord-000248-zueoyesj	291	7	p63	p63	NN
cord-000248-zueoyesj	291	8	is	be	VBZ
cord-000248-zueoyesj	291	9	a	a	DT
cord-000248-zueoyesj	291	10	key	key	JJ
cord-000248-zueoyesj	291	11	regulator	regulator	NN
cord-000248-zueoyesj	291	12	of	of	IN
cord-000248-zueoyesj	291	13	the	the	DT
cord-000248-zueoyesj	291	14	development	development	NN
cord-000248-zueoyesj	291	15	of	of	IN
cord-000248-zueoyesj	291	16	stratified	stratified	JJ
cord-000248-zueoyesj	291	17	epithelial	epithelial	JJ
cord-000248-zueoyesj	291	18	tissues	tissue	NNS
cord-000248-zueoyesj	291	19	[	[	-LRB-
cord-000248-zueoyesj	291	20	113	113	CD
cord-000248-zueoyesj	291	21	]	]	-RRB-
cord-000248-zueoyesj	291	22	and	and	CC
cord-000248-zueoyesj	291	23	that	that	IN
cord-000248-zueoyesj	291	24	its	-PRON-	PRP$
cord-000248-zueoyesj	291	25	deletion	deletion	NN
cord-000248-zueoyesj	291	26	results	result	NNS
cord-000248-zueoyesj	291	27	in	in	IN
cord-000248-zueoyesj	291	28	loss	loss	NN
cord-000248-zueoyesj	291	29	of	of	IN
cord-000248-zueoyesj	291	30	stratified	stratified	JJ
cord-000248-zueoyesj	291	31	epithelial	epithelial	NN
cord-000248-zueoyesj	291	32	and	and	CC
cord-000248-zueoyesj	291	33	of	of	IN
cord-000248-zueoyesj	291	34	all	all	DT
cord-000248-zueoyesj	291	35	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	291	36	[	[	-LRB-
cord-000248-zueoyesj	291	37	117	117	CD
cord-000248-zueoyesj	291	38	]	]	-RRB-
cord-000248-zueoyesj	291	39	.	.	.
cord-000248-zueoyesj	292	1	Melanocytes	melanocyte	NNS
cord-000248-zueoyesj	292	2	also	also	RB
cord-000248-zueoyesj	292	3	express	express	VBP
cord-000248-zueoyesj	292	4	two	two	CD
cord-000248-zueoyesj	292	5	isoforms	isoform	NNS
cord-000248-zueoyesj	292	6	of	of	IN
cord-000248-zueoyesj	292	7	p63	p63	CD
cord-000248-zueoyesj	292	8	[	[	-LRB-
cord-000248-zueoyesj	292	9	118	118	CD
cord-000248-zueoyesj	292	10	]	]	-RRB-
cord-000248-zueoyesj	292	11	,	,	,
cord-000248-zueoyesj	292	12	but	but	CC
cord-000248-zueoyesj	292	13	p63	p63	JJ
cord-000248-zueoyesj	292	14	expression	expression	NN
cord-000248-zueoyesj	292	15	is	be	VBZ
cord-000248-zueoyesj	292	16	not	not	RB
cord-000248-zueoyesj	292	17	reported	report	VBN
cord-000248-zueoyesj	292	18	in	in	IN
cord-000248-zueoyesj	292	19	57	57	CD
cord-000248-zueoyesj	292	20	out	out	IN
cord-000248-zueoyesj	292	21	of	of	IN
cord-000248-zueoyesj	292	22	59	59	CD
cord-000248-zueoyesj	292	23	tumors	tumor	NNS
cord-000248-zueoyesj	292	24	in	in	IN
cord-000248-zueoyesj	292	25	a	a	DT
cord-000248-zueoyesj	292	26	tissue	tissue	NN
cord-000248-zueoyesj	292	27	microarray	microarray	NN
cord-000248-zueoyesj	292	28	study	study	NN
cord-000248-zueoyesj	292	29	performed	perform	VBN
cord-000248-zueoyesj	292	30	by	by	IN
cord-000248-zueoyesj	292	31	Brinck	Brinck	NNP
cord-000248-zueoyesj	292	32	et	et	NNP
cord-000248-zueoyesj	292	33	al	al	NNP
cord-000248-zueoyesj	292	34	.	.	.
cord-000248-zueoyesj	293	1	[	[	-LRB-
cord-000248-zueoyesj	293	2	119	119	CD
cord-000248-zueoyesj	293	3	]	]	-RRB-
cord-000248-zueoyesj	293	4	.	.	.
cord-000248-zueoyesj	294	1	It	-PRON-	PRP
cord-000248-zueoyesj	294	2	is	be	VBZ
cord-000248-zueoyesj	294	3	clear	clear	JJ
cord-000248-zueoyesj	294	4	that	that	IN
cord-000248-zueoyesj	294	5	the	the	DT
cord-000248-zueoyesj	294	6	the	the	DT
cord-000248-zueoyesj	294	7	role	role	NN
cord-000248-zueoyesj	294	8	of	of	IN
cord-000248-zueoyesj	294	9	loss	loss	NN
cord-000248-zueoyesj	294	10	of	of	IN
cord-000248-zueoyesj	294	11	expression	expression	NN
cord-000248-zueoyesj	294	12	of	of	IN
cord-000248-zueoyesj	294	13	TP63	TP63	NNP
cord-000248-zueoyesj	294	14	in	in	IN
cord-000248-zueoyesj	294	15	melanoma	melanoma	NN
cord-000248-zueoyesj	294	16	warrants	warrant	NNS
cord-000248-zueoyesj	294	17	further	further	JJ
cord-000248-zueoyesj	294	18	investigation	investigation	NN
cord-000248-zueoyesj	294	19	.	.	.
cord-000248-zueoyesj	295	1	ADA	ADA	NNP
cord-000248-zueoyesj	295	2	-(Adenosine	-(Adenosine	NNP
cord-000248-zueoyesj	295	3	deaminase	deaminase	NNP
cord-000248-zueoyesj	295	4	)	)	-RRB-
cord-000248-zueoyesj	295	5	and	and	CC
cord-000248-zueoyesj	295	6	DPP4	DPP4	NNP
cord-000248-zueoyesj	295	7	/	/	SYM
cord-000248-zueoyesj	295	8	CD26	CD26	NNP
cord-000248-zueoyesj	295	9	(	(	-LRB-
cord-000248-zueoyesj	295	10	Dipeptidylpeptidase	Dipeptidylpeptidase	NNP
cord-000248-zueoyesj	295	11	4	4	CD
cord-000248-zueoyesj	295	12	,	,	,
cord-000248-zueoyesj	295	13	CD26	CD26	NNP
cord-000248-zueoyesj	295	14	,	,	,
cord-000248-zueoyesj	295	15	adenosine	adenosine	NN
cord-000248-zueoyesj	295	16	deaminase	deaminase	NN
cord-000248-zueoyesj	295	17	complexing	complexe	VBG
cord-000248-zueoyesj	295	18	protein	protein	NN
cord-000248-zueoyesj	295	19	2	2	CD
cord-000248-zueoyesj	295	20	)	)	-RRB-
cord-000248-zueoyesj	295	21	.	.	.
cord-000248-zueoyesj	296	1	A	a	DT
cord-000248-zueoyesj	296	2	link	link	NN
cord-000248-zueoyesj	296	3	between	between	IN
cord-000248-zueoyesj	296	4	TP63	TP63	NNP
cord-000248-zueoyesj	296	5	and	and	CC
cord-000248-zueoyesj	296	6	ADA	ADA	NNP
cord-000248-zueoyesj	296	7	has	have	VBZ
cord-000248-zueoyesj	296	8	already	already	RB
cord-000248-zueoyesj	296	9	been	be	VBN
cord-000248-zueoyesj	296	10	reported	report	VBN
cord-000248-zueoyesj	296	11	in	in	IN
cord-000248-zueoyesj	296	12	the	the	DT
cord-000248-zueoyesj	296	13	literature	literature	NN
cord-000248-zueoyesj	296	14	.	.	.
cord-000248-zueoyesj	297	1	ADA	ADA	NNP
cord-000248-zueoyesj	297	2	is	be	VBZ
cord-000248-zueoyesj	297	3	a	a	DT
cord-000248-zueoyesj	297	4	gene	gene	NN
cord-000248-zueoyesj	297	5	involved	involve	VBN
cord-000248-zueoyesj	297	6	in	in	IN
cord-000248-zueoyesj	297	7	cell	cell	NN
cord-000248-zueoyesj	297	8	division	division	NN
cord-000248-zueoyesj	297	9	and	and	CC
cord-000248-zueoyesj	297	10	proliferatation	proliferatation	NN
cord-000248-zueoyesj	297	11	[	[	-LRB-
cord-000248-zueoyesj	297	12	120	120	CD
cord-000248-zueoyesj	297	13	]	]	-RRB-
cord-000248-zueoyesj	297	14	and	and	CC
cord-000248-zueoyesj	297	15	it	-PRON-	PRP
cord-000248-zueoyesj	297	16	has	have	VBZ
cord-000248-zueoyesj	297	17	been	be	VBN
cord-000248-zueoyesj	297	18	suggested	suggest	VBN
cord-000248-zueoyesj	297	19	to	to	TO
cord-000248-zueoyesj	297	20	have	have	VB
cord-000248-zueoyesj	297	21	a	a	DT
cord-000248-zueoyesj	297	22	regulatory	regulatory	JJ
cord-000248-zueoyesj	297	23	role	role	NN
cord-000248-zueoyesj	297	24	in	in	IN
cord-000248-zueoyesj	297	25	dendritic	dendritic	JJ
cord-000248-zueoyesj	297	26	cell	cell	NN
cord-000248-zueoyesj	297	27	innate	innate	JJ
cord-000248-zueoyesj	297	28	immune	immune	JJ
cord-000248-zueoyesj	297	29	responses	response	NNS
cord-000248-zueoyesj	297	30	[	[	-LRB-
cord-000248-zueoyesj	297	31	121	121	CD
cord-000248-zueoyesj	297	32	]	]	-RRB-
cord-000248-zueoyesj	297	33	.Translational	.translational	JJ
cord-000248-zueoyesj	297	34	modification	modification	NN
cord-000248-zueoyesj	297	35	is	be	VBZ
cord-000248-zueoyesj	297	36	also	also	RB
cord-000248-zueoyesj	297	37	a	a	DT
cord-000248-zueoyesj	297	38	function	function	NN
cord-000248-zueoyesj	297	39	of	of	IN
cord-000248-zueoyesj	297	40	p63	p63	CD
cord-000248-zueoyesj	297	41	.	.	.
cord-000248-zueoyesj	298	1	Sbisa	Sbisa	NNP
cord-000248-zueoyesj	298	2	et	et	FW
cord-000248-zueoyesj	298	3	al	al	NNP
cord-000248-zueoyesj	298	4	.	.	NNP
cord-000248-zueoyesj	298	5	have	have	VBP
cord-000248-zueoyesj	298	6	proved	prove	VBN
cord-000248-zueoyesj	298	7	that	that	IN
cord-000248-zueoyesj	298	8	ADA	ADA	NNP
cord-000248-zueoyesj	298	9	is	be	VBZ
cord-000248-zueoyesj	298	10	a	a	DT
cord-000248-zueoyesj	298	11	direct	direct	JJ
cord-000248-zueoyesj	298	12	target	target	NN
cord-000248-zueoyesj	298	13	of	of	IN
cord-000248-zueoyesj	298	14	isoforms	isoform	NNS
cord-000248-zueoyesj	298	15	of	of	IN
cord-000248-zueoyesj	298	16	p63	p63	CD
cord-000248-zueoyesj	298	17	,	,	,
cord-000248-zueoyesj	298	18	which	which	WDT
cord-000248-zueoyesj	298	19	is	be	VBZ
cord-000248-zueoyesj	298	20	an	an	DT
cord-000248-zueoyesj	298	21	important	important	JJ
cord-000248-zueoyesj	298	22	discovery	discovery	NN
cord-000248-zueoyesj	298	23	as	as	IN
cord-000248-zueoyesj	298	24	ADA	ADA	NNP
cord-000248-zueoyesj	298	25	has	have	VBZ
cord-000248-zueoyesj	298	26	two	two	CD
cord-000248-zueoyesj	298	27	TP53	TP53	NNP
cord-000248-zueoyesj	298	28	binding	bind	VBG
cord-000248-zueoyesj	298	29	sites	site	NNS
cord-000248-zueoyesj	298	30	,	,	,
cord-000248-zueoyesj	298	31	leading	lead	VBG
cord-000248-zueoyesj	298	32	to	to	IN
cord-000248-zueoyesj	298	33	a	a	DT
cord-000248-zueoyesj	298	34	complex	complex	JJ
cord-000248-zueoyesj	298	35	metabolic	metabolic	JJ
cord-000248-zueoyesj	298	36	balance	balance	NN
cord-000248-zueoyesj	298	37	due	due	IN
cord-000248-zueoyesj	298	38	to	to	IN
cord-000248-zueoyesj	298	39	the	the	DT
cord-000248-zueoyesj	298	40	different	different	JJ
cord-000248-zueoyesj	298	41	relationships	relationship	NNS
cord-000248-zueoyesj	298	42	between	between	IN
cord-000248-zueoyesj	298	43	this	this	DT
cord-000248-zueoyesj	298	44	trio	trio	NN
cord-000248-zueoyesj	298	45	and	and	CC
cord-000248-zueoyesj	298	46	p21	p21	NN
cord-000248-zueoyesj	298	47	yet	yet	RB
cord-000248-zueoyesj	298	48	to	to	TO
cord-000248-zueoyesj	298	49	be	be	VB
cord-000248-zueoyesj	298	50	completely	completely	RB
cord-000248-zueoyesj	298	51	elicitated	elicitate	VBN
cord-000248-zueoyesj	298	52	[	[	-LRB-
cord-000248-zueoyesj	298	53	120	120	CD
cord-000248-zueoyesj	298	54	,	,	,
cord-000248-zueoyesj	298	55	122	122	CD
cord-000248-zueoyesj	298	56	]	]	-RRB-
cord-000248-zueoyesj	298	57	.	.	.
cord-000248-zueoyesj	299	1	Several	several	JJ
cord-000248-zueoyesj	299	2	studies	study	NNS
cord-000248-zueoyesj	299	3	indicate	indicate	VBP
cord-000248-zueoyesj	299	4	elevation	elevation	NN
cord-000248-zueoyesj	299	5	of	of	IN
cord-000248-zueoyesj	299	6	adenosine	adenosine	NN
cord-000248-zueoyesj	299	7	deaminase	deaminase	NNP
cord-000248-zueoyesj	299	8	levels	level	NNS
cord-000248-zueoyesj	299	9	in	in	IN
cord-000248-zueoyesj	299	10	sera	sera	NNP
cord-000248-zueoyesj	299	11	of	of	IN
cord-000248-zueoyesj	299	12	breast	breast	NN
cord-000248-zueoyesj	299	13	[	[	-LRB-
cord-000248-zueoyesj	299	14	123	123	CD
cord-000248-zueoyesj	299	15	]	]	-RRB-
cord-000248-zueoyesj	299	16	,	,	,
cord-000248-zueoyesj	299	17	head	head	NN
cord-000248-zueoyesj	299	18	and	and	CC
cord-000248-zueoyesj	299	19	neck	neck	NN
cord-000248-zueoyesj	299	20	[	[	-LRB-
cord-000248-zueoyesj	299	21	124	124	CD
cord-000248-zueoyesj	299	22	]	]	-RRB-
cord-000248-zueoyesj	299	23	,	,	,
cord-000248-zueoyesj	299	24	colorectal	colorectal	JJ
cord-000248-zueoyesj	299	25	[	[	-LRB-
cord-000248-zueoyesj	299	26	125	125	CD
cord-000248-zueoyesj	299	27	]	]	-RRB-
cord-000248-zueoyesj	299	28	,	,	,
cord-000248-zueoyesj	299	29	acute	acute	JJ
cord-000248-zueoyesj	299	30	lymphoblastic	lymphoblastic	JJ
cord-000248-zueoyesj	299	31	leukaemia	leukaemia	NN
cord-000248-zueoyesj	299	32	[	[	-LRB-
cord-000248-zueoyesj	299	33	126	126	CD
cord-000248-zueoyesj	299	34	]	]	-RRB-
cord-000248-zueoyesj	299	35	and	and	CC
cord-000248-zueoyesj	299	36	laryngeal	laryngeal	NN
cord-000248-zueoyesj	299	37	cancers	cancer	NNS
cord-000248-zueoyesj	299	38	[	[	-LRB-
cord-000248-zueoyesj	299	39	127	127	CD
cord-000248-zueoyesj	299	40	]	]	-RRB-
cord-000248-zueoyesj	299	41	.	.	.
cord-000248-zueoyesj	300	1	We	-PRON-	PRP
cord-000248-zueoyesj	300	2	observe	observe	VBP
cord-000248-zueoyesj	300	3	a	a	DT
cord-000248-zueoyesj	300	4	marked	marked	JJ
cord-000248-zueoyesj	300	5	increase	increase	NN
cord-000248-zueoyesj	300	6	of	of	IN
cord-000248-zueoyesj	300	7	expression	expression	NN
cord-000248-zueoyesj	300	8	of	of	IN
cord-000248-zueoyesj	300	9	a	a	DT
cord-000248-zueoyesj	300	10	probe	probe	NN
cord-000248-zueoyesj	300	11	for	for	IN
cord-000248-zueoyesj	300	12	ADA	ADA	NNP
cord-000248-zueoyesj	300	13	with	with	IN
cord-000248-zueoyesj	300	14	melanoma	melanoma	NN
cord-000248-zueoyesj	300	15	progression	progression	NN
cord-000248-zueoyesj	300	16	while	while	IN
cord-000248-zueoyesj	300	17	at	at	IN
cord-000248-zueoyesj	300	18	the	the	DT
cord-000248-zueoyesj	300	19	same	same	JJ
cord-000248-zueoyesj	300	20	time	time	NN
cord-000248-zueoyesj	300	21	we	-PRON-	PRP
cord-000248-zueoyesj	300	22	observe	observe	VBP
cord-000248-zueoyesj	300	23	a	a	DT
cord-000248-zueoyesj	300	24	loss	loss	NN
cord-000248-zueoyesj	300	25	of	of	IN
cord-000248-zueoyesj	300	26	expression	expression	NN
cord-000248-zueoyesj	300	27	of	of	IN
cord-000248-zueoyesj	300	28	a	a	DT
cord-000248-zueoyesj	300	29	probe	probe	NN
cord-000248-zueoyesj	300	30	corresponding	correspond	VBG
cord-000248-zueoyesj	300	31	to	to	IN
cord-000248-zueoyesj	300	32	DPP4	DPP4	NNP
cord-000248-zueoyesj	300	33	/	/	SYM
cord-000248-zueoyesj	300	34	CD26	CD26	NNP
cord-000248-zueoyesj	300	35	(	(	-LRB-
cord-000248-zueoyesj	300	36	Dipeptidylpeptidase	Dipeptidylpeptidase	NNP
cord-000248-zueoyesj	300	37	4	4	CD
cord-000248-zueoyesj	300	38	,	,	,
cord-000248-zueoyesj	300	39	CD26	CD26	NNP
cord-000248-zueoyesj	300	40	,	,	,
cord-000248-zueoyesj	300	41	adenosine	adenosine	NN
cord-000248-zueoyesj	300	42	deaminase	deaminase	NN
cord-000248-zueoyesj	300	43	complexing	complexe	VBG
cord-000248-zueoyesj	300	44	protein	protein	NN
cord-000248-zueoyesj	300	45	2	2	CD
cord-000248-zueoyesj	300	46	)	)	-RRB-
cord-000248-zueoyesj	300	47	,	,	,
cord-000248-zueoyesj	300	48	a	a	DT
cord-000248-zueoyesj	300	49	membrane	membrane	NN
cord-000248-zueoyesj	300	50	-	-	HYPH
cord-000248-zueoyesj	300	51	bound	bind	VBN
cord-000248-zueoyesj	300	52	,	,	,
cord-000248-zueoyesj	300	53	proline	proline	NN
cord-000248-zueoyesj	300	54	-	-	HYPH
cord-000248-zueoyesj	300	55	specific	specific	JJ
cord-000248-zueoyesj	300	56	serine	serine	NN
cord-000248-zueoyesj	300	57	protease	protease	NN
cord-000248-zueoyesj	300	58	[	[	-LRB-
cord-000248-zueoyesj	300	59	128	128	CD
cord-000248-zueoyesj	300	60	]	]	-RRB-
cord-000248-zueoyesj	300	61	that	that	WDT
cord-000248-zueoyesj	300	62	has	have	VBZ
cord-000248-zueoyesj	300	63	been	be	VBN
cord-000248-zueoyesj	300	64	attributed	attribute	VBN
cord-000248-zueoyesj	300	65	tumor	tumor	NN
cord-000248-zueoyesj	300	66	suppressor	suppressor	NN
cord-000248-zueoyesj	300	67	functions	function	NNS
cord-000248-zueoyesj	300	68	[	[	-LRB-
cord-000248-zueoyesj	300	69	129	129	CD
cord-000248-zueoyesj	300	70	]	]	-RRB-
cord-000248-zueoyesj	300	71	.	.	.
cord-000248-zueoyesj	301	1	It	-PRON-	PRP
cord-000248-zueoyesj	301	2	has	have	VBZ
cord-000248-zueoyesj	301	3	been	be	VBN
cord-000248-zueoyesj	301	4	previously	previously	RB
cord-000248-zueoyesj	301	5	reported	report	VBN
cord-000248-zueoyesj	301	6	that	that	IN
cord-000248-zueoyesj	301	7	loss	loss	NN
cord-000248-zueoyesj	301	8	of	of	IN
cord-000248-zueoyesj	301	9	DPP4	DPP4	NNP
cord-000248-zueoyesj	301	10	immunostaining	immunostaining	NN
cord-000248-zueoyesj	301	11	helps	help	VBZ
cord-000248-zueoyesj	301	12	to	to	TO
cord-000248-zueoyesj	301	13	discriminate	discriminate	VB
cord-000248-zueoyesj	301	14	malignant	malignant	JJ
cord-000248-zueoyesj	301	15	melanomas	melanoma	NNS
cord-000248-zueoyesj	301	16	from	from	IN
cord-000248-zueoyesj	301	17	deep	deep	JJ
cord-000248-zueoyesj	301	18	penetrating	penetrating	JJ
cord-000248-zueoyesj	301	19	nevi	nevus	NNS
cord-000248-zueoyesj	301	20	,	,	,
cord-000248-zueoyesj	301	21	a	a	DT
cord-000248-zueoyesj	301	22	variant	variant	NN
cord-000248-zueoyesj	301	23	of	of	IN
cord-000248-zueoyesj	301	24	benign	benign	JJ
cord-000248-zueoyesj	301	25	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	301	26	nevus	nevus	NN
cord-000248-zueoyesj	301	27	[	[	-LRB-
cord-000248-zueoyesj	301	28	130	130	CD
cord-000248-zueoyesj	301	29	]	]	-RRB-
cord-000248-zueoyesj	301	30	and	and	CC
cord-000248-zueoyesj	301	31	early	early	JJ
cord-000248-zueoyesj	301	32	reports	report	NNS
cord-000248-zueoyesj	301	33	of	of	IN
cord-000248-zueoyesj	301	34	their	-PRON-	PRP$
cord-000248-zueoyesj	301	35	absence	absence	NN
cord-000248-zueoyesj	301	36	in	in	IN
cord-000248-zueoyesj	301	37	metastatic	metastatic	JJ
cord-000248-zueoyesj	301	38	melanomas	melanoma	NNS
cord-000248-zueoyesj	301	39	exist	exist	VBP
cord-000248-zueoyesj	301	40	[	[	-LRB-
cord-000248-zueoyesj	301	41	131	131	CD
cord-000248-zueoyesj	301	42	,	,	,
cord-000248-zueoyesj	301	43	132	132	CD
cord-000248-zueoyesj	301	44	]	]	-RRB-
cord-000248-zueoyesj	301	45	.	.	.
cord-000248-zueoyesj	302	1	As	as	IN
cord-000248-zueoyesj	302	2	deep	deep	JJ
cord-000248-zueoyesj	302	3	penetrating	penetrate	VBG
cord-000248-zueoyesj	302	4	nevi	nevus	NNS
cord-000248-zueoyesj	302	5	can	can	MD
cord-000248-zueoyesj	302	6	mimic	mimic	VB
cord-000248-zueoyesj	302	7	the	the	DT
cord-000248-zueoyesj	302	8	vertical	vertical	JJ
cord-000248-zueoyesj	302	9	growth	growth	NN
cord-000248-zueoyesj	302	10	phase	phase	NN
cord-000248-zueoyesj	302	11	of	of	IN
cord-000248-zueoyesj	302	12	nodular	nodular	JJ
cord-000248-zueoyesj	302	13	malignant	malignant	JJ
cord-000248-zueoyesj	302	14	melanoma	melanoma	NN
cord-000248-zueoyesj	302	15	,	,	,
cord-000248-zueoyesj	302	16	and	and	CC
cord-000248-zueoyesj	302	17	ADA	ADA	NNP
cord-000248-zueoyesj	302	18	could	could	MD
cord-000248-zueoyesj	302	19	potentially	potentially	RB
cord-000248-zueoyesj	302	20	be	be	VB
cord-000248-zueoyesj	302	21	downregulat	downregulat	JJ
cord-000248-zueoyesj	302	22	-	-	:
cord-000248-zueoyesj	302	23	ing	e	VBG
cord-000248-zueoyesj	302	24	DPP4	DPP4	NNP
cord-000248-zueoyesj	302	25	[	[	-LRB-
cord-000248-zueoyesj	302	26	133	133	CD
cord-000248-zueoyesj	302	27	,	,	,
cord-000248-zueoyesj	302	28	134	134	CD
cord-000248-zueoyesj	302	29	]	]	-RRB-
cord-000248-zueoyesj	303	1	we	-PRON-	PRP
cord-000248-zueoyesj	303	2	believe	believe	VBP
cord-000248-zueoyesj	303	3	that	that	IN
cord-000248-zueoyesj	303	4	the	the	DT
cord-000248-zueoyesj	303	5	elicitation	elicitation	NN
cord-000248-zueoyesj	303	6	of	of	IN
cord-000248-zueoyesj	303	7	the	the	DT
cord-000248-zueoyesj	303	8	complementary	complementary	JJ
cord-000248-zueoyesj	303	9	role	role	NN
cord-000248-zueoyesj	303	10	of	of	IN
cord-000248-zueoyesj	303	11	these	these	DT
cord-000248-zueoyesj	303	12	two	two	CD
cord-000248-zueoyesj	303	13	biomarkers	biomarker	NNS
cord-000248-zueoyesj	303	14	to	to	TO
cord-000248-zueoyesj	303	15	distinguish	distinguish	VB
cord-000248-zueoyesj	303	16	these	these	DT
cord-000248-zueoyesj	303	17	two	two	CD
cord-000248-zueoyesj	303	18	entities	entity	NNS
cord-000248-zueoyesj	303	19	is	be	VBZ
cord-000248-zueoyesj	303	20	necessary	necessary	JJ
cord-000248-zueoyesj	303	21	and	and	CC
cord-000248-zueoyesj	303	22	also	also	RB
cord-000248-zueoyesj	303	23	warrants	warrant	VBZ
cord-000248-zueoyesj	303	24	further	further	JJ
cord-000248-zueoyesj	303	25	clinical	clinical	JJ
cord-000248-zueoyesj	303	26	studies	study	NNS
cord-000248-zueoyesj	303	27	.	.	.
cord-000248-zueoyesj	304	1	PLK1	PLK1	NNP
cord-000248-zueoyesj	304	2	(	(	-LRB-
cord-000248-zueoyesj	304	3	Polo	Polo	NNP
cord-000248-zueoyesj	304	4	-	-	HYPH
cord-000248-zueoyesj	304	5	like	like	JJ
cord-000248-zueoyesj	304	6	kinase	kinase	NN
cord-000248-zueoyesj	304	7	1	1	CD
cord-000248-zueoyesj	304	8	(	(	-LRB-
cord-000248-zueoyesj	304	9	Drosophila	Drosophila	NNP
cord-000248-zueoyesj	304	10	)	)	-RRB-
cord-000248-zueoyesj	304	11	)	)	-RRB-
cord-000248-zueoyesj	304	12	.	.	.
cord-000248-zueoyesj	305	1	Another	another	DT
cord-000248-zueoyesj	305	2	probe	probe	NN
cord-000248-zueoyesj	305	3	for	for	IN
cord-000248-zueoyesj	305	4	gene	gene	NN
cord-000248-zueoyesj	305	5	that	that	WDT
cord-000248-zueoyesj	305	6	ranks	rank	VBZ
cord-000248-zueoyesj	305	7	high	high	RB
cord-000248-zueoyesj	305	8	as	as	IN
cord-000248-zueoyesj	305	9	a	a	DT
cord-000248-zueoyesj	305	10	positive	positive	JJ
cord-000248-zueoyesj	305	11	marker	marker	NN
cord-000248-zueoyesj	305	12	of	of	IN
cord-000248-zueoyesj	305	13	metastasis	metastasis	NN
cord-000248-zueoyesj	305	14	is	be	VBZ
cord-000248-zueoyesj	305	15	PLK1	PLK1	NNP
cord-000248-zueoyesj	305	16	,	,	,
cord-000248-zueoyesj	305	17	Polo	Polo	NNP
cord-000248-zueoyesj	305	18	-	-	HYPH
cord-000248-zueoyesj	305	19	like	like	JJ
cord-000248-zueoyesj	305	20	kinase	kinase	NN
cord-000248-zueoyesj	305	21	1	1	CD
cord-000248-zueoyesj	305	22	,	,	,
cord-000248-zueoyesj	305	23	Serine	Serine	NNP
cord-000248-zueoyesj	305	24	/	/	SYM
cord-000248-zueoyesj	305	25	Threonine	Threonine	NNP
cord-000248-zueoyesj	305	26	protein	protein	NN
cord-000248-zueoyesj	305	27	kinase	kinase	VBD
cord-000248-zueoyesj	305	28	13	13	CD
cord-000248-zueoyesj	305	29	(	(	-LRB-
cord-000248-zueoyesj	305	30	AA629262	AA629262	NNP
cord-000248-zueoyesj	305	31	)	)	-RRB-
cord-000248-zueoyesj	305	32	.	.	.
cord-000248-zueoyesj	306	1	PLK1	PLK1	NNP
cord-000248-zueoyesj	306	2	is	be	VBZ
cord-000248-zueoyesj	306	3	a	a	DT
cord-000248-zueoyesj	306	4	centrosomal	centrosomal	JJ
cord-000248-zueoyesj	306	5	kinase	kinase	NN
cord-000248-zueoyesj	306	6	[	[	-LRB-
cord-000248-zueoyesj	306	7	135	135	CD
cord-000248-zueoyesj	306	8	]	]	-RRB-
cord-000248-zueoyesj	306	9	which	which	WDT
cord-000248-zueoyesj	306	10	is	be	VBZ
cord-000248-zueoyesj	306	11	Figure	Figure	NNP
cord-000248-zueoyesj	306	12	7	7	CD
cord-000248-zueoyesj	306	13	.	.	.
cord-000248-zueoyesj	307	1	Scatter	scatter	VB
cord-000248-zueoyesj	307	2	plot	plot	NN
cord-000248-zueoyesj	307	3	showing	show	VBG
cord-000248-zueoyesj	307	4	the	the	DT
cord-000248-zueoyesj	307	5	expression	expression	NN
cord-000248-zueoyesj	307	6	of	of	IN
cord-000248-zueoyesj	307	7	the	the	DT
cord-000248-zueoyesj	307	8	probe	probe	NN
cord-000248-zueoyesj	307	9	corresponding	correspond	VBG
cord-000248-zueoyesj	307	10	to	to	IN
cord-000248-zueoyesj	307	11	ADA	ADA	NNP
cord-000248-zueoyesj	307	12	(	(	-LRB-
cord-000248-zueoyesj	307	13	Adenosine	adenosine	NN
cord-000248-zueoyesj	307	14	deaminase	deaminase	NNP
cord-000248-zueoyesj	307	15	)	)	-RRB-
cord-000248-zueoyesj	307	16	,	,	,
cord-000248-zueoyesj	307	17	AA683578	AA683578	NNP
cord-000248-zueoyesj	307	18	(	(	-LRB-
cord-000248-zueoyesj	307	19	y	y	NN
cord-000248-zueoyesj	307	20	-	-	HYPH
cord-000248-zueoyesj	307	21	axis	axis	NN
cord-000248-zueoyesj	307	22	)	)	-RRB-
cord-000248-zueoyesj	308	1	and	and	CC
cord-000248-zueoyesj	308	2	TP63	TP63	NNP
cord-000248-zueoyesj	308	3	(	(	-LRB-
cord-000248-zueoyesj	308	4	Tumor	tumor	NN
cord-000248-zueoyesj	308	5	protein	protein	NN
cord-000248-zueoyesj	308	6	p63	p63	CD
cord-000248-zueoyesj	308	7	)	)	-RRB-
cord-000248-zueoyesj	308	8	,	,	,
cord-000248-zueoyesj	308	9	AA455929	AA455929	VBN
cord-000248-zueoyesj	308	10	(	(	-LRB-
cord-000248-zueoyesj	308	11	x	x	NN
cord-000248-zueoyesj	308	12	-	-	NN
cord-000248-zueoyesj	308	13	axis	axis	NN
cord-000248-zueoyesj	308	14	)	)	-RRB-
cord-000248-zueoyesj	308	15	.	.	.
cord-000248-zueoyesj	309	1	All	all	PDT
cord-000248-zueoyesj	309	2	the	the	DT
cord-000248-zueoyesj	309	3	samples	sample	NNS
cord-000248-zueoyesj	309	4	that	that	WDT
cord-000248-zueoyesj	309	5	have	have	VBP
cord-000248-zueoyesj	309	6	TP63	TP63	NNP
cord-000248-zueoyesj	309	7	expression	expression	NN
cord-000248-zueoyesj	309	8	are	be	VBP
cord-000248-zueoyesj	309	9	normal	normal	JJ
cord-000248-zueoyesj	309	10	or	or	CC
cord-000248-zueoyesj	309	11	nevi	nevus	NNS
cord-000248-zueoyesj	309	12	,	,	,
cord-000248-zueoyesj	309	13	with	with	IN
cord-000248-zueoyesj	309	14	two	two	CD
cord-000248-zueoyesj	309	15	primary	primary	JJ
cord-000248-zueoyesj	309	16	melanomas	melanoma	NNS
cord-000248-zueoyesj	309	17	still	still	RB
cord-000248-zueoyesj	309	18	preserving	preserve	VBG
cord-000248-zueoyesj	309	19	TP63	TP63	NNP
cord-000248-zueoyesj	309	20	expression	expression	NN
cord-000248-zueoyesj	309	21	but	but	CC
cord-000248-zueoyesj	309	22	with	with	IN
cord-000248-zueoyesj	309	23	higher	high	JJR
cord-000248-zueoyesj	309	24	ADA	ADA	NNP
cord-000248-zueoyesj	309	25	.	.	.
cord-000248-zueoyesj	310	1	The	the	DT
cord-000248-zueoyesj	310	2	trend	trend	NN
cord-000248-zueoyesj	310	3	reverses	reverse	VBZ
cord-000248-zueoyesj	310	4	for	for	IN
cord-000248-zueoyesj	310	5	the	the	DT
cord-000248-zueoyesj	310	6	rest	rest	NN
cord-000248-zueoyesj	310	7	of	of	IN
cord-000248-zueoyesj	310	8	the	the	DT
cord-000248-zueoyesj	310	9	primary	primary	JJ
cord-000248-zueoyesj	310	10	melanoma	melanoma	NN
cord-000248-zueoyesj	310	11	samples	sample	NNS
cord-000248-zueoyesj	310	12	and	and	CC
cord-000248-zueoyesj	310	13	the	the	DT
cord-000248-zueoyesj	310	14	metastatic	metastatic	JJ
cord-000248-zueoyesj	310	15	ones	one	NNS
cord-000248-zueoyesj	310	16	,	,	,
cord-000248-zueoyesj	310	17	which	which	WDT
cord-000248-zueoyesj	310	18	all	all	DT
cord-000248-zueoyesj	310	19	express	express	VBP
cord-000248-zueoyesj	310	20	ADA	ADA	NNP
cord-000248-zueoyesj	310	21	but	but	CC
cord-000248-zueoyesj	310	22	not	not	RB
cord-000248-zueoyesj	310	23	TP63	TP63	NNP
cord-000248-zueoyesj	310	24	.	.	.
cord-000248-zueoyesj	311	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	312	1	/journal.pone.0012262.g007	/journal.pone.0012262.g007	.
cord-000248-zueoyesj	313	1	Analogously	analogously	RB
cord-000248-zueoyesj	313	2	,	,	,
cord-000248-zueoyesj	313	3	we	-PRON-	PRP
cord-000248-zueoyesj	313	4	compute	compute	VBP
cord-000248-zueoyesj	313	5	the	the	DT
cord-000248-zueoyesj	313	6	Jensen	Jensen	NNP
cord-000248-zueoyesj	313	7	-	-	HYPH
cord-000248-zueoyesj	313	8	Shannon	Shannon	NNP
cord-000248-zueoyesj	313	9	divergence	divergence	NN
cord-000248-zueoyesj	313	10	of	of	IN
cord-000248-zueoyesj	313	11	each	each	DT
cord-000248-zueoyesj	313	12	sample	sample	NN
cord-000248-zueoyesj	313	13	with	with	IN
cord-000248-zueoyesj	313	14	the	the	DT
cord-000248-zueoyesj	313	15	average	average	JJ
cord-000248-zueoyesj	313	16	metastastic	metastastic	JJ
cord-000248-zueoyesj	313	17	profile	profile	NN
cord-000248-zueoyesj	313	18	and	and	CC
cord-000248-zueoyesj	313	19	we	-PRON-	PRP
cord-000248-zueoyesj	313	20	also	also	RB
cord-000248-zueoyesj	313	21	compute	compute	VBP
cord-000248-zueoyesj	313	22	the	the	DT
cord-000248-zueoyesj	313	23	correlation	correlation	NN
cord-000248-zueoyesj	313	24	of	of	IN
cord-000248-zueoyesj	313	25	each	each	DT
cord-000248-zueoyesj	313	26	probe	probe	NN
cord-000248-zueoyesj	313	27	with	with	IN
cord-000248-zueoyesj	313	28	this	this	DT
cord-000248-zueoyesj	313	29	measure	measure	NN
cord-000248-zueoyesj	313	30	(	(	-LRB-
cord-000248-zueoyesj	313	31	y	y	NN
cord-000248-zueoyesj	313	32	-	-	HYPH
cord-000248-zueoyesj	313	33	axis	axis	NN
cord-000248-zueoyesj	313	34	)	)	-RRB-
cord-000248-zueoyesj	313	35	.	.	.
cord-000248-zueoyesj	314	1	The	the	DT
cord-000248-zueoyesj	314	2	position	position	NN
cord-000248-zueoyesj	314	3	of	of	IN
cord-000248-zueoyesj	314	4	one	one	CD
cord-000248-zueoyesj	314	5	probe	probe	NN
cord-000248-zueoyesj	314	6	corresponding	correspond	VBG
cord-000248-zueoyesj	314	7	to	to	IN
cord-000248-zueoyesj	314	8	the	the	DT
cord-000248-zueoyesj	314	9	TP63	TP63	NNP
cord-000248-zueoyesj	314	10	gene	gene	NN
cord-000248-zueoyesj	314	11	(	(	-LRB-
cord-000248-zueoyesj	314	12	Tumor	tumor	NN
cord-000248-zueoyesj	314	13	protein	protein	NN
cord-000248-zueoyesj	314	14	p63	p63	NN
cord-000248-zueoyesj	314	15	,	,	,
cord-000248-zueoyesj	314	16	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	314	17	transcription	transcription	NN
cord-000248-zueoyesj	314	18	factor	factor	NN
cord-000248-zueoyesj	314	19	KET	KET	NNP
cord-000248-zueoyesj	314	20	)	)	-RRB-
cord-000248-zueoyesj	314	21	,	,	,
cord-000248-zueoyesj	314	22	AA455929	aa455929	NN
cord-000248-zueoyesj	314	23	,	,	,
cord-000248-zueoyesj	314	24	is	be	VBZ
cord-000248-zueoyesj	314	25	highlighted	highlight	VBN
cord-000248-zueoyesj	314	26	.	.	.
cord-000248-zueoyesj	315	1	The	the	DT
cord-000248-zueoyesj	315	2	expression	expression	NN
cord-000248-zueoyesj	315	3	of	of	IN
cord-000248-zueoyesj	315	4	this	this	DT
cord-000248-zueoyesj	315	5	probe	probe	NN
cord-000248-zueoyesj	315	6	has	have	VBZ
cord-000248-zueoyesj	315	7	a	a	DT
cord-000248-zueoyesj	315	8	relatively	relatively	RB
cord-000248-zueoyesj	315	9	high	high	JJ
cord-000248-zueoyesj	315	10	negative	negative	JJ
cord-000248-zueoyesj	315	11	correlation	correlation	NN
cord-000248-zueoyesj	315	12	with	with	IN
cord-000248-zueoyesj	315	13	the	the	DT
cord-000248-zueoyesj	315	14	Jensen	Jensen	NNP
cord-000248-zueoyesj	315	15	-	-	HYPH
cord-000248-zueoyesj	315	16	Shannon	Shannon	NNP
cord-000248-zueoyesj	315	17	divergence	divergence	NN
cord-000248-zueoyesj	315	18	of	of	IN
cord-000248-zueoyesj	315	19	the	the	DT
cord-000248-zueoyesj	315	20	normal	normal	JJ
cord-000248-zueoyesj	315	21	skin	skin	NN
cord-000248-zueoyesj	315	22	type	type	NN
cord-000248-zueoyesj	315	23	(	(	-LRB-
cord-000248-zueoyesj	315	24	JSM0-Spearman	JSM0-Spearman	NNP
cord-000248-zueoyesj	315	25	=	=	SYM
cord-000248-zueoyesj	315	26	20.63632	20.63632	CD
cord-000248-zueoyesj	315	27	)	)	-RRB-
cord-000248-zueoyesj	316	1	while	while	IN
cord-000248-zueoyesj	316	2	at	at	IN
cord-000248-zueoyesj	316	3	the	the	DT
cord-000248-zueoyesj	316	4	same	same	JJ
cord-000248-zueoyesj	316	5	time	time	NN
cord-000248-zueoyesj	316	6	is	be	VBZ
cord-000248-zueoyesj	316	7	has	have	VBZ
cord-000248-zueoyesj	316	8	a	a	DT
cord-000248-zueoyesj	316	9	positive	positive	JJ
cord-000248-zueoyesj	316	10	correlation	correlation	NN
cord-000248-zueoyesj	316	11	with	with	IN
cord-000248-zueoyesj	316	12	the	the	DT
cord-000248-zueoyesj	316	13	Jensen	Jensen	NNP
cord-000248-zueoyesj	316	14	-	-	HYPH
cord-000248-zueoyesj	316	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	316	16	divergence	divergence	NN
cord-000248-zueoyesj	316	17	of	of	IN
cord-000248-zueoyesj	316	18	the	the	DT
cord-000248-zueoyesj	316	19	metastasis	metastasis	NN
cord-000248-zueoyesj	316	20	profile	profile	NN
cord-000248-zueoyesj	316	21	(	(	-LRB-
cord-000248-zueoyesj	316	22	JSM5	JSM5	NNP
cord-000248-zueoyesj	316	23	=	=	SYM
cord-000248-zueoyesj	316	24	0.62138	0.62138	CD
cord-000248-zueoyesj	316	25	)	)	-RRB-
cord-000248-zueoyesj	316	26	.	.	.
cord-000248-zueoyesj	317	1	The	the	DT
cord-000248-zueoyesj	317	2	first	first	JJ
cord-000248-zueoyesj	317	3	probe	probe	NN
cord-000248-zueoyesj	317	4	that	that	WDT
cord-000248-zueoyesj	317	5	presents	present	VBZ
cord-000248-zueoyesj	317	6	an	an	DT
cord-000248-zueoyesj	317	7	opposite	opposite	JJ
cord-000248-zueoyesj	317	8	behaviour	behaviour	NN
cord-000248-zueoyesj	317	9	is	be	VBZ
cord-000248-zueoyesj	317	10	one	one	CD
cord-000248-zueoyesj	317	11	for	for	IN
cord-000248-zueoyesj	317	12	ADA	ADA	NNP
cord-000248-zueoyesj	317	13	(	(	-LRB-
cord-000248-zueoyesj	317	14	Adenosine	adenosine	NN
cord-000248-zueoyesj	317	15	deaminase	deaminase	NNP
cord-000248-zueoyesj	317	16	)	)	-RRB-
cord-000248-zueoyesj	317	17	,	,	,
cord-000248-zueoyesj	317	18	AA683578	aa683578	NN
cord-000248-zueoyesj	317	19	.	.	.
cord-000248-zueoyesj	318	1	Probes	probe	NNS
cord-000248-zueoyesj	318	2	for	for	IN
cord-000248-zueoyesj	318	3	SPP1	SPP1	NNS
cord-000248-zueoyesj	318	4	(	(	-LRB-
cord-000248-zueoyesj	318	5	Secreted	secreted	NN
cord-000248-zueoyesj	318	6	phosphoprotein	phosphoprotein	NN
cord-000248-zueoyesj	318	7	1	1	CD
cord-000248-zueoyesj	318	8	or	or	CC
cord-000248-zueoyesj	318	9	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	318	10	)	)	-RRB-
cord-000248-zueoyesj	318	11	and	and	CC
cord-000248-zueoyesj	318	12	PLK1	PLK1	NNP
cord-000248-zueoyesj	318	13	(	(	-LRB-
cord-000248-zueoyesj	318	14	Polo	Polo	NNP
cord-000248-zueoyesj	318	15	-	-	HYPH
cord-000248-zueoyesj	318	16	like	like	JJ
cord-000248-zueoyesj	318	17	kinase	kinase	NN
cord-000248-zueoyesj	318	18	1	1	CD
cord-000248-zueoyesj	318	19	or	or	CC
cord-000248-zueoyesj	318	20	Drosophila	Drosophila	NNP
cord-000248-zueoyesj	318	21	)	)	-RRB-
cord-000248-zueoyesj	318	22	are	be	VBP
cord-000248-zueoyesj	318	23	also	also	RB
cord-000248-zueoyesj	318	24	highlighted	highlight	VBN
cord-000248-zueoyesj	318	25	.	.	.
cord-000248-zueoyesj	319	1	While	while	IN
cord-000248-zueoyesj	319	2	PLK1	PLK1	NNP
cord-000248-zueoyesj	319	3	is	be	VBZ
cord-000248-zueoyesj	319	4	currently	currently	RB
cord-000248-zueoyesj	319	5	less	less	RBR
cord-000248-zueoyesj	319	6	recognized	recognize	VBN
cord-000248-zueoyesj	319	7	as	as	IN
cord-000248-zueoyesj	319	8	a	a	DT
cord-000248-zueoyesj	319	9	biomarker	biomarker	NN
cord-000248-zueoyesj	319	10	in	in	IN
cord-000248-zueoyesj	319	11	melanoma	melanoma	NN
cord-000248-zueoyesj	319	12	research	research	NN
cord-000248-zueoyesj	319	13	,	,	,
cord-000248-zueoyesj	319	14	the	the	DT
cord-000248-zueoyesj	319	15	importance	importance	NN
cord-000248-zueoyesj	319	16	of	of	IN
cord-000248-zueoyesj	319	17	SPP1	SPP1	NNS
cord-000248-zueoyesj	319	18	in	in	IN
cord-000248-zueoyesj	319	19	cutaneous	cutaneous	JJ
cord-000248-zueoyesj	319	20	pathology	pathology	NN
cord-000248-zueoyesj	319	21	[	[	-LRB-
cord-000248-zueoyesj	319	22	315	315	CD
cord-000248-zueoyesj	319	23	,	,	,
cord-000248-zueoyesj	319	24	318	318	CD
cord-000248-zueoyesj	319	25	,	,	,
cord-000248-zueoyesj	319	26	320	320	CD
cord-000248-zueoyesj	319	27	,	,	,
cord-000248-zueoyesj	319	28	321	321	CD
cord-000248-zueoyesj	319	29	]	]	-RRB-
cord-000248-zueoyesj	319	30	and	and	CC
cord-000248-zueoyesj	319	31	in	in	IN
cord-000248-zueoyesj	319	32	particular	particular	JJ
cord-000248-zueoyesj	319	33	in	in	IN
cord-000248-zueoyesj	319	34	melanoma	melanoma	NN
cord-000248-zueoyesj	319	35	[	[	-LRB-
cord-000248-zueoyesj	319	36	208	208	CD
cord-000248-zueoyesj	319	37	,	,	,
cord-000248-zueoyesj	319	38	209	209	CD
cord-000248-zueoyesj	319	39	,	,	,
cord-000248-zueoyesj	319	40	210	210	CD
cord-000248-zueoyesj	319	41	,	,	,
cord-000248-zueoyesj	319	42	211	211	CD
cord-000248-zueoyesj	319	43	,	,	,
cord-000248-zueoyesj	319	44	212	212	CD
cord-000248-zueoyesj	319	45	,	,	,
cord-000248-zueoyesj	319	46	214	214	CD
cord-000248-zueoyesj	319	47	,	,	,
cord-000248-zueoyesj	319	48	215	215	CD
cord-000248-zueoyesj	319	49	,	,	,
cord-000248-zueoyesj	319	50	216	216	CD
cord-000248-zueoyesj	319	51	,	,	,
cord-000248-zueoyesj	319	52	217	217	CD
cord-000248-zueoyesj	319	53	,	,	,
cord-000248-zueoyesj	319	54	218	218	CD
cord-000248-zueoyesj	319	55	,	,	,
cord-000248-zueoyesj	319	56	219	219	CD
cord-000248-zueoyesj	319	57	,	,	,
cord-000248-zueoyesj	319	58	222	222	CD
cord-000248-zueoyesj	319	59	,	,	,
cord-000248-zueoyesj	319	60	226	226	CD
cord-000248-zueoyesj	319	61	,	,	,
cord-000248-zueoyesj	319	62	264	264	CD
cord-000248-zueoyesj	319	63	,	,	,
cord-000248-zueoyesj	319	64	314	314	CD
cord-000248-zueoyesj	319	65	,	,	,
cord-000248-zueoyesj	319	66	315	315	CD
cord-000248-zueoyesj	319	67	,	,	,
cord-000248-zueoyesj	319	68	316	316	CD
cord-000248-zueoyesj	319	69	,	,	,
cord-000248-zueoyesj	319	70	317	317	CD
cord-000248-zueoyesj	319	71	,	,	,
cord-000248-zueoyesj	319	72	319	319	CD
cord-000248-zueoyesj	319	73	,	,	,
cord-000248-zueoyesj	319	74	322	322	CD
cord-000248-zueoyesj	319	75	,	,	,
cord-000248-zueoyesj	319	76	323	323	CD
cord-000248-zueoyesj	319	77	,	,	,
cord-000248-zueoyesj	319	78	324	324	CD
cord-000248-zueoyesj	319	79	,	,	,
cord-000248-zueoyesj	319	80	325	325	CD
cord-000248-zueoyesj	319	81	,	,	,
cord-000248-zueoyesj	319	82	326	326	CD
cord-000248-zueoyesj	319	83	,	,	,
cord-000248-zueoyesj	319	84	327	327	CD
cord-000248-zueoyesj	319	85	,	,	,
cord-000248-zueoyesj	319	86	328	328	CD
cord-000248-zueoyesj	319	87	,	,	,
cord-000248-zueoyesj	319	88	804	804	CD
cord-000248-zueoyesj	319	89	,	,	,
cord-000248-zueoyesj	319	90	805	805	CD
cord-000248-zueoyesj	319	91	,	,	,
cord-000248-zueoyesj	319	92	806	806	CD
cord-000248-zueoyesj	319	93	,	,	,
cord-000248-zueoyesj	319	94	807	807	CD
cord-000248-zueoyesj	319	95	,	,	,
cord-000248-zueoyesj	319	96	808	808	CD
cord-000248-zueoyesj	319	97	,	,	,
cord-000248-zueoyesj	319	98	809	809	CD
cord-000248-zueoyesj	319	99	]	]	-RRB-
cord-000248-zueoyesj	319	100	is	be	VBZ
cord-000248-zueoyesj	319	101	increasing	increase	VBG
cord-000248-zueoyesj	319	102	.	.	.
cord-000248-zueoyesj	320	1	Using	use	VBG
cord-000248-zueoyesj	320	2	a	a	DT
cord-000248-zueoyesj	320	3	5-biomarker	5-biomarker	CD
cord-000248-zueoyesj	320	4	panel	panel	NN
cord-000248-zueoyesj	320	5	that	that	WDT
cord-000248-zueoyesj	320	6	included	include	VBD
cord-000248-zueoyesj	320	7	SPP1	SPP1	NNP
cord-000248-zueoyesj	320	8	,	,	,
cord-000248-zueoyesj	320	9	Kashani	Kashani	NNP
cord-000248-zueoyesj	320	10	-	-	HYPH
cord-000248-zueoyesj	320	11	Sabet	Sabet	NNP
cord-000248-zueoyesj	320	12	et	et	NNP
cord-000248-zueoyesj	320	13	al	al	NNP
cord-000248-zueoyesj	320	14	.	.	.
cord-000248-zueoyesj	321	1	used	use	VBN
cord-000248-zueoyesj	321	2	tissue	tissue	NN
cord-000248-zueoyesj	321	3	microarrays	microarray	NNS
cord-000248-zueoyesj	321	4	on	on	IN
cord-000248-zueoyesj	321	5	693	693	CD
cord-000248-zueoyesj	321	6	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	321	7	neoplasms	neoplasm	NNS
cord-000248-zueoyesj	321	8	to	to	TO
cord-000248-zueoyesj	321	9	show	show	VB
cord-000248-zueoyesj	321	10	that	that	IN
cord-000248-zueoyesj	321	11	SPP1	SPP1	NNP
cord-000248-zueoyesj	321	12	expression	expression	NN
cord-000248-zueoyesj	321	13	collaborates	collaborate	VBZ
cord-000248-zueoyesj	321	14	significantly	significantly	RB
cord-000248-zueoyesj	321	15	improving	improve	VBG
cord-000248-zueoyesj	321	16	the	the	DT
cord-000248-zueoyesj	321	17	detection	detection	NN
cord-000248-zueoyesj	321	18	of	of	IN
cord-000248-zueoyesj	321	19	high	high	JJ
cord-000248-zueoyesj	321	20	percentage	percentage	NN
cord-000248-zueoyesj	321	21	of	of	IN
cord-000248-zueoyesj	321	22	melanomas	melanoma	NNS
cord-000248-zueoyesj	321	23	arising	arise	VBG
cord-000248-zueoyesj	321	24	in	in	IN
cord-000248-zueoyesj	321	25	a	a	DT
cord-000248-zueoyesj	321	26	nevus	nevus	NN
cord-000248-zueoyesj	321	27	,	,	,
cord-000248-zueoyesj	321	28	Spitz	Spitz	NNP
cord-000248-zueoyesj	321	29	nevi	nevus	NNS
cord-000248-zueoyesj	321	30	,	,	,
cord-000248-zueoyesj	321	31	dysplastic	dysplastic	JJ
cord-000248-zueoyesj	321	32	nevi	nevus	NNS
cord-000248-zueoyesj	321	33	and	and	CC
cord-000248-zueoyesj	321	34	misdiagnosed	misdiagnosed	JJ
cord-000248-zueoyesj	321	35	lesions	lesion	NNS
cord-000248-zueoyesj	321	36	[	[	-LRB-
cord-000248-zueoyesj	321	37	253	253	CD
cord-000248-zueoyesj	321	38	]	]	-RRB-
cord-000248-zueoyesj	321	39	.	.	.
cord-000248-zueoyesj	322	1	Like	like	IN
cord-000248-zueoyesj	322	2	in	in	IN
cord-000248-zueoyesj	322	3	the	the	DT
cord-000248-zueoyesj	322	4	case	case	NN
cord-000248-zueoyesj	322	5	of	of	IN
cord-000248-zueoyesj	322	6	prostate	prostate	NN
cord-000248-zueoyesj	322	7	cancer	cancer	NN
cord-000248-zueoyesj	322	8	(	(	-LRB-
cord-000248-zueoyesj	322	9	Figure	Figure	NNP
cord-000248-zueoyesj	322	10	3	3	CD
cord-000248-zueoyesj	322	11	,	,	,
cord-000248-zueoyesj	322	12	in	in	IN
cord-000248-zueoyesj	322	13	which	which	WDT
cord-000248-zueoyesj	322	14	KLK3	KLK3	NNP
cord-000248-zueoyesj	322	15	/	/	SYM
cord-000248-zueoyesj	322	16	PSA	PSA	NNP
cord-000248-zueoyesj	322	17	-Prostate	-Prostate	:
cord-000248-zueoyesj	322	18	Specific	specific	JJ
cord-000248-zueoyesj	322	19	Antigen	Antigen	NNP
cord-000248-zueoyesj	322	20	was	be	VBD
cord-000248-zueoyesj	322	21	highlighted	highlight	VBN
cord-000248-zueoyesj	322	22	)	)	-RRB-
cord-000248-zueoyesj	322	23	,	,	,
cord-000248-zueoyesj	322	24	our	-PRON-	PRP$
cord-000248-zueoyesj	322	25	method	method	NN
cord-000248-zueoyesj	322	26	allows	allow	VBZ
cord-000248-zueoyesj	322	27	the	the	DT
cord-000248-zueoyesj	322	28	detection	detection	NN
cord-000248-zueoyesj	322	29	of	of	IN
cord-000248-zueoyesj	322	30	important	important	JJ
cord-000248-zueoyesj	322	31	biomarkers	biomarker	NNS
cord-000248-zueoyesj	322	32	with	with	IN
cord-000248-zueoyesj	322	33	a	a	DT
cord-000248-zueoyesj	322	34	high	high	JJ
cord-000248-zueoyesj	322	35	degree	degree	NN
cord-000248-zueoyesj	322	36	of	of	IN
cord-000248-zueoyesj	322	37	concordance	concordance	NN
cord-000248-zueoyesj	322	38	with	with	IN
cord-000248-zueoyesj	322	39	current	current	JJ
cord-000248-zueoyesj	322	40	biological	biological	JJ
cord-000248-zueoyesj	322	41	understanding	understanding	NN
cord-000248-zueoyesj	322	42	of	of	IN
cord-000248-zueoyesj	322	43	metastatic	metastatic	JJ
cord-000248-zueoyesj	322	44	processes	process	NNS
cord-000248-zueoyesj	322	45	.	.	.
cord-000248-zueoyesj	323	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	323	2	/	/	SYM
cord-000248-zueoyesj	323	3	journal.pone.0012262.g006	journal.pone.0012262.g006	NNP
cord-000248-zueoyesj	323	4	regarded	regard	VBD
cord-000248-zueoyesj	323	5	as	as	IN
cord-000248-zueoyesj	323	6	being	be	VBG
cord-000248-zueoyesj	323	7	linked	link	VBN
cord-000248-zueoyesj	323	8	to	to	IN
cord-000248-zueoyesj	323	9	centrosome	centrosome	VB
cord-000248-zueoyesj	323	10	maturation	maturation	NN
cord-000248-zueoyesj	323	11	and	and	CC
cord-000248-zueoyesj	323	12	spindle	spindle	NN
cord-000248-zueoyesj	323	13	assembly	assembly	NN
cord-000248-zueoyesj	323	14	[	[	-LRB-
cord-000248-zueoyesj	323	15	135	135	CD
cord-000248-zueoyesj	323	16	]	]	-RRB-
cord-000248-zueoyesj	323	17	.	.	.
cord-000248-zueoyesj	324	1	PLK1	plk1	JJ
cord-000248-zueoyesj	324	2	expression	expression	NN
cord-000248-zueoyesj	324	3	has	have	VBZ
cord-000248-zueoyesj	324	4	also	also	RB
cord-000248-zueoyesj	324	5	been	be	VBN
cord-000248-zueoyesj	324	6	singled	single	VBN
cord-000248-zueoyesj	324	7	out	out	RP
cord-000248-zueoyesj	324	8	as	as	IN
cord-000248-zueoyesj	324	9	a	a	DT
cord-000248-zueoyesj	324	10	biomarker	biomarker	NN
cord-000248-zueoyesj	324	11	of	of	IN
cord-000248-zueoyesj	324	12	a	a	DT
cord-000248-zueoyesj	324	13	'	'	''
cord-000248-zueoyesj	324	14	'	'	''
cord-000248-zueoyesj	324	15	death	death	NN
cord-000248-zueoyesj	324	16	-	-	HYPH
cord-000248-zueoyesj	324	17	from	from	IN
cord-000248-zueoyesj	324	18	-	-	HYPH
cord-000248-zueoyesj	324	19	cancer	cancer	NN
cord-000248-zueoyesj	324	20	'	'	''
cord-000248-zueoyesj	324	21	'	'	''
cord-000248-zueoyesj	324	22	signature	signature	NN
cord-000248-zueoyesj	324	23	,	,	,
cord-000248-zueoyesj	324	24	sharing	share	VBG
cord-000248-zueoyesj	324	25	with	with	IN
cord-000248-zueoyesj	324	26	others	other	NNS
cord-000248-zueoyesj	324	27	the	the	DT
cord-000248-zueoyesj	324	28	function	function	NN
cord-000248-zueoyesj	324	29	of	of	IN
cord-000248-zueoyesj	324	30	being	be	VBG
cord-000248-zueoyesj	324	31	an	an	DT
cord-000248-zueoyesj	324	32	activator	activator	NN
cord-000248-zueoyesj	324	33	of	of	IN
cord-000248-zueoyesj	324	34	mitotic	mitotic	JJ
cord-000248-zueoyesj	324	35	spindle	spindle	NN
cord-000248-zueoyesj	324	36	check	check	NN
cord-000248-zueoyesj	324	37	point	point	NN
cord-000248-zueoyesj	324	38	proteins	protein	NNS
cord-000248-zueoyesj	324	39	.	.	.
cord-000248-zueoyesj	325	1	With	with	IN
cord-000248-zueoyesj	325	2	other	other	JJ
cord-000248-zueoyesj	325	3	proteins	protein	NNS
cord-000248-zueoyesj	325	4	it	-PRON-	PRP
cord-000248-zueoyesj	325	5	would	would	MD
cord-000248-zueoyesj	325	6	has	have	VBZ
cord-000248-zueoyesj	325	7	a	a	DT
cord-000248-zueoyesj	325	8	stem	stem	NN
cord-000248-zueoyesj	325	9	cell	cell	NN
cord-000248-zueoyesj	325	10	-	-	HYPH
cord-000248-zueoyesj	325	11	like	like	JJ
cord-000248-zueoyesj	325	12	expression	expression	NN
cord-000248-zueoyesj	325	13	profile	profile	NN
cord-000248-zueoyesj	325	14	phenotypically	phenotypically	RB
cord-000248-zueoyesj	325	15	characterized	characterize	VBN
cord-000248-zueoyesj	325	16	by	by	IN
cord-000248-zueoyesj	325	17	enabling	enable	VBG
cord-000248-zueoyesj	325	18	metastasis	metastasis	NN
cord-000248-zueoyesj	325	19	with	with	IN
cord-000248-zueoyesj	325	20	anoikis	anoikis	NN
cord-000248-zueoyesj	325	21	resistance	resistance	NN
cord-000248-zueoyesj	325	22	and	and	CC
cord-000248-zueoyesj	325	23	disregulated	disregulated	JJ
cord-000248-zueoyesj	325	24	cell	cell	NN
cord-000248-zueoyesj	325	25	-	-	HYPH
cord-000248-zueoyesj	325	26	cycle	cycle	NN
cord-000248-zueoyesj	325	27	control	control	NN
cord-000248-zueoyesj	325	28	[	[	-LRB-
cord-000248-zueoyesj	325	29	136	136	CD
cord-000248-zueoyesj	325	30	]	]	-RRB-
cord-000248-zueoyesj	325	31	.	.	.
cord-000248-zueoyesj	326	1	PLK1	plk1	JJ
cord-000248-zueoyesj	326	2	inhibition	inhibition	NN
cord-000248-zueoyesj	326	3	could	could	MD
cord-000248-zueoyesj	326	4	be	be	VB
cord-000248-zueoyesj	326	5	a	a	DT
cord-000248-zueoyesj	326	6	common	common	JJ
cord-000248-zueoyesj	326	7	target	target	NN
cord-000248-zueoyesj	326	8	for	for	IN
cord-000248-zueoyesj	326	9	gastric	gastric	JJ
cord-000248-zueoyesj	326	10	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	326	11	[	[	-LRB-
cord-000248-zueoyesj	326	12	137	137	CD
cord-000248-zueoyesj	326	13	]	]	-RRB-
cord-000248-zueoyesj	326	14	,	,	,
cord-000248-zueoyesj	326	15	bladder	bladder	NN
cord-000248-zueoyesj	326	16	cancer	cancer	NN
cord-000248-zueoyesj	326	17	[	[	-LRB-
cord-000248-zueoyesj	326	18	138	138	CD
cord-000248-zueoyesj	326	19	]	]	-RRB-
cord-000248-zueoyesj	326	20	,	,	,
cord-000248-zueoyesj	326	21	colon	colon	NN
cord-000248-zueoyesj	326	22	cancer	cancer	NN
cord-000248-zueoyesj	326	23	[	[	-LRB-
cord-000248-zueoyesj	326	24	139	139	CD
cord-000248-zueoyesj	326	25	,	,	,
cord-000248-zueoyesj	326	26	140	140	CD
cord-000248-zueoyesj	326	27	]	]	-RRB-
cord-000248-zueoyesj	326	28	,	,	,
cord-000248-zueoyesj	326	29	hepatocellular	hepatocellular	JJ
cord-000248-zueoyesj	326	30	carcinoma	carcinoma	NN
cord-000248-zueoyesj	326	31	[	[	-LRB-
cord-000248-zueoyesj	326	32	141	141	CD
cord-000248-zueoyesj	326	33	]	]	-RRB-
cord-000248-zueoyesj	326	34	,	,	,
cord-000248-zueoyesj	326	35	medullary	medullary	JJ
cord-000248-zueoyesj	326	36	thyroid	thyroid	NN
cord-000248-zueoyesj	326	37	carcinoma	carcinoma	NN
cord-000248-zueoyesj	326	38	[	[	-LRB-
cord-000248-zueoyesj	326	39	142	142	CD
cord-000248-zueoyesj	326	40	]	]	-RRB-
cord-000248-zueoyesj	326	41	,	,	,
cord-000248-zueoyesj	326	42	esophageal	esophageal	JJ
cord-000248-zueoyesj	326	43	cancer	cancer	NN
cord-000248-zueoyesj	326	44	[	[	-LRB-
cord-000248-zueoyesj	326	45	143	143	CD
cord-000248-zueoyesj	326	46	]	]	-RRB-
cord-000248-zueoyesj	326	47	,	,	,
cord-000248-zueoyesj	326	48	pancreatic	pancreatic	JJ
cord-000248-zueoyesj	326	49	cancer	cancer	NN
cord-000248-zueoyesj	326	50	[	[	-LRB-
cord-000248-zueoyesj	326	51	144	144	CD
cord-000248-zueoyesj	326	52	]	]	-RRB-
cord-000248-zueoyesj	327	1	and	and	CC
cord-000248-zueoyesj	327	2	in	in	IN
cord-000248-zueoyesj	327	3	some	some	DT
cord-000248-zueoyesj	327	4	types	type	NNS
cord-000248-zueoyesj	327	5	of	of	IN
cord-000248-zueoyesj	327	6	non	non	JJ
cord-000248-zueoyesj	327	7	-	-	JJ
cord-000248-zueoyesj	327	8	Hodgkin	Hodgkin	NNP
cord-000248-zueoyesj	327	9	lymphomas	lymphoma	NNS
cord-000248-zueoyesj	327	10	[	[	-LRB-
cord-000248-zueoyesj	327	11	145	145	CD
cord-000248-zueoyesj	327	12	]	]	-RRB-
cord-000248-zueoyesj	327	13	and	and	CC
cord-000248-zueoyesj	327	14	breast	breast	NN
cord-000248-zueoyesj	327	15	cancer	cancer	NN
cord-000248-zueoyesj	327	16	[	[	-LRB-
cord-000248-zueoyesj	327	17	146	146	CD
cord-000248-zueoyesj	327	18	]	]	-RRB-
cord-000248-zueoyesj	327	19	.	.	.
cord-000248-zueoyesj	328	1	PLK1	PLK1	NNP
cord-000248-zueoyesj	328	2	's	's	POS
cord-000248-zueoyesj	328	3	Spearman	Spearman	NNP
cord-000248-zueoyesj	328	4	correlation	correlation	NN
cord-000248-zueoyesj	328	5	with	with	IN
cord-000248-zueoyesj	328	6	the	the	DT
cord-000248-zueoyesj	328	7	values	value	NNS
cord-000248-zueoyesj	328	8	of	of	IN
cord-000248-zueoyesj	328	9	the	the	DT
cord-000248-zueoyesj	328	10	Jensen	Jensen	NNP
cord-000248-zueoyesj	328	11	-	-	HYPH
cord-000248-zueoyesj	328	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	328	13	divergence	divergence	NN
cord-000248-zueoyesj	328	14	of	of	IN
cord-000248-zueoyesj	328	15	samples	sample	NNS
cord-000248-zueoyesj	328	16	with	with	IN
cord-000248-zueoyesj	328	17	the	the	DT
cord-000248-zueoyesj	328	18	normal	normal	JJ
cord-000248-zueoyesj	328	19	skin	skin	NN
cord-000248-zueoyesj	328	20	profile	profile	NN
cord-000248-zueoyesj	328	21	is	be	VBZ
cord-000248-zueoyesj	328	22	relatively	relatively	RB
cord-000248-zueoyesj	328	23	high	high	JJ
cord-000248-zueoyesj	328	24	(	(	-LRB-
cord-000248-zueoyesj	328	25	0.5863	0.5863	CD
cord-000248-zueoyesj	328	26	)	)	-RRB-
cord-000248-zueoyesj	328	27	.	.	.
cord-000248-zueoyesj	329	1	PLK1	PLK1	NNP
cord-000248-zueoyesj	329	2	also	also	RB
cord-000248-zueoyesj	329	3	has	have	VBZ
cord-000248-zueoyesj	329	4	a	a	DT
cord-000248-zueoyesj	329	5	high	high	JJ
cord-000248-zueoyesj	329	6	value	value	NN
cord-000248-zueoyesj	329	7	of	of	IN
cord-000248-zueoyesj	329	8	(	(	-LRB-
cord-000248-zueoyesj	329	9	negative	negative	JJ
cord-000248-zueoyesj	329	10	)	)	-RRB-
cord-000248-zueoyesj	330	1	Spearman	spearman	NN
cord-000248-zueoyesj	330	2	correlation	correlation	NN
cord-000248-zueoyesj	330	3	with	with	IN
cord-000248-zueoyesj	330	4	the	the	DT
cord-000248-zueoyesj	330	5	values	value	NNS
cord-000248-zueoyesj	330	6	of	of	IN
cord-000248-zueoyesj	330	7	the	the	DT
cord-000248-zueoyesj	330	8	Jensen	Jensen	NNP
cord-000248-zueoyesj	330	9	-	-	HYPH
cord-000248-zueoyesj	330	10	Shannon	Shannon	NNP
cord-000248-zueoyesj	330	11	divergence	divergence	NN
cord-000248-zueoyesj	330	12	of	of	IN
cord-000248-zueoyesj	330	13	samples	sample	NNS
cord-000248-zueoyesj	330	14	with	with	IN
cord-000248-zueoyesj	330	15	the	the	DT
cord-000248-zueoyesj	330	16	average	average	JJ
cord-000248-zueoyesj	330	17	metastatic	metastatic	JJ
cord-000248-zueoyesj	330	18	profile	profile	NN
cord-000248-zueoyesj	330	19	(	(	-LRB-
cord-000248-zueoyesj	330	20	20.44571	20.44571	CD
cord-000248-zueoyesj	331	1	In	in	IN
cord-000248-zueoyesj	331	2	the	the	DT
cord-000248-zueoyesj	331	3	comparison	comparison	NN
cord-000248-zueoyesj	331	4	,	,	,
cord-000248-zueoyesj	331	5	it	-PRON-	PRP
cord-000248-zueoyesj	331	6	was	be	VBD
cord-000248-zueoyesj	331	7	found	find	VBN
cord-000248-zueoyesj	331	8	that	that	IN
cord-000248-zueoyesj	331	9	metastatic	metastatic	JJ
cord-000248-zueoyesj	331	10	malignant	malignant	JJ
cord-000248-zueoyesj	331	11	melanomas	melanoma	NNS
cord-000248-zueoyesj	331	12	with	with	IN
cord-000248-zueoyesj	331	13	expressed	express	VBN
cord-000248-zueoyesj	331	14	PLK1	PLK1	NNP
cord-000248-zueoyesj	331	15	at	at	IN
cord-000248-zueoyesj	331	16	markedly	markedly	RB
cord-000248-zueoyesj	331	17	elevated	elevate	VBN
cord-000248-zueoyesj	331	18	levels	level	NNS
cord-000248-zueoyesj	331	19	(	(	-LRB-
cord-000248-zueoyesj	331	20	median	median	NN
cord-000248-zueoyesj	331	21	,	,	,
cord-000248-zueoyesj	331	22	60.00	60.00	CD
cord-000248-zueoyesj	331	23	%	%	NN
cord-000248-zueoyesj	331	24	vs.	vs.	IN
cord-000248-zueoyesj	331	25	37.98	37.98	CD
cord-000248-zueoyesj	331	26	%	%	NN
cord-000248-zueoyesj	331	27	;	;	:
cord-000248-zueoyesj	331	28	p	p	NN
cord-000248-zueoyesj	331	29	-	-	HYPH
cord-000248-zueoyesj	331	30	value,0.000053	value,0.000053	NNP
cord-000248-zueoyesj	331	31	)	)	-RRB-
cord-000248-zueoyesj	331	32	,	,	,
cord-000248-zueoyesj	331	33	concluding	conclude	VBG
cord-000248-zueoyesj	331	34	that	that	IN
cord-000248-zueoyesj	331	35	PLK1	PLK1	NNP
cord-000248-zueoyesj	331	36	is	be	VBZ
cord-000248-zueoyesj	331	37	a	a	DT
cord-000248-zueoyesj	331	38	reliable	reliable	JJ
cord-000248-zueoyesj	331	39	biomarker	biomarker	NN
cord-000248-zueoyesj	331	40	for	for	IN
cord-000248-zueoyesj	331	41	patients	patient	NNS
cord-000248-zueoyesj	331	42	at	at	IN
cord-000248-zueoyesj	331	43	high	high	JJ
cord-000248-zueoyesj	331	44	risk	risk	NN
cord-000248-zueoyesj	331	45	of	of	IN
cord-000248-zueoyesj	331	46	metastases	metastasis	NNS
cord-000248-zueoyesj	331	47	,	,	,
cord-000248-zueoyesj	331	48	even	even	RB
cord-000248-zueoyesj	331	49	when	when	WRB
cord-000248-zueoyesj	331	50	the	the	DT
cord-000248-zueoyesj	331	51	most	most	RBS
cord-000248-zueoyesj	331	52	important	important	JJ
cord-000248-zueoyesj	331	53	prognostic	prognostic	JJ
cord-000248-zueoyesj	331	54	clinical	clinical	JJ
cord-000248-zueoyesj	331	55	factor	factor	NN
cord-000248-zueoyesj	331	56	(	(	-LRB-
cord-000248-zueoyesj	331	57	Breslow	Breslow	NNP
cord-000248-zueoyesj	331	58	's	's	POS
cord-000248-zueoyesj	331	59	maximum	maximum	JJ
cord-000248-zueoyesj	331	60	thickness	thickness	NN
cord-000248-zueoyesj	331	61	of	of	IN
cord-000248-zueoyesj	331	62	the	the	DT
cord-000248-zueoyesj	331	63	primary	primary	JJ
cord-000248-zueoyesj	331	64	malignant	malignant	JJ
cord-000248-zueoyesj	331	65	melanoma	melanoma	NN
cord-000248-zueoyesj	331	66	)	)	-RRB-
cord-000248-zueoyesj	331	67	indicates	indicate	VBZ
cord-000248-zueoyesj	331	68	the	the	DT
cord-000248-zueoyesj	331	69	contrary	contrary	JJ
cord-000248-zueoyesj	331	70	[	[	-LRB-
cord-000248-zueoyesj	331	71	147	147	CD
cord-000248-zueoyesj	331	72	]	]	-RRB-
cord-000248-zueoyesj	331	73	.	.	.
cord-000248-zueoyesj	332	1	We	-PRON-	PRP
cord-000248-zueoyesj	332	2	consider	consider	VBP
cord-000248-zueoyesj	332	3	this	this	DT
cord-000248-zueoyesj	332	4	an	an	DT
cord-000248-zueoyesj	332	5	important	important	JJ
cord-000248-zueoyesj	332	6	finding	finding	NN
cord-000248-zueoyesj	332	7	as	as	IN
cord-000248-zueoyesj	332	8	PLK1	PLK1	NNP
cord-000248-zueoyesj	332	9	silencing	silencing	NN
cord-000248-zueoyesj	332	10	is	be	VBZ
cord-000248-zueoyesj	332	11	already	already	RB
cord-000248-zueoyesj	332	12	part	part	NN
cord-000248-zueoyesj	332	13	of	of	IN
cord-000248-zueoyesj	332	14	an	an	DT
cord-000248-zueoyesj	332	15	integrated	integrated	JJ
cord-000248-zueoyesj	332	16	oncolytic	oncolytic	JJ
cord-000248-zueoyesj	332	17	adenovirus	adenovirus	NN
cord-000248-zueoyesj	332	18	approach	approach	NN
cord-000248-zueoyesj	332	19	currently	currently	RB
cord-000248-zueoyesj	332	20	being	be	VBG
cord-000248-zueoyesj	332	21	studied	study	VBN
cord-000248-zueoyesj	332	22	in	in	IN
cord-000248-zueoyesj	332	23	mice	mice	NN
cord-000248-zueoyesj	332	24	models	model	NNS
cord-000248-zueoyesj	332	25	of	of	IN
cord-000248-zueoyesj	332	26	orthotopic	orthotopic	JJ
cord-000248-zueoyesj	332	27	gastric	gastric	JJ
cord-000248-zueoyesj	332	28	carcinoma	carcinoma	NN
cord-000248-zueoyesj	332	29	[	[	-LRB-
cord-000248-zueoyesj	332	30	148	148	CD
cord-000248-zueoyesj	332	31	]	]	-RRB-
cord-000248-zueoyesj	332	32	and	and	CC
cord-000248-zueoyesj	332	33	has	have	VBZ
cord-000248-zueoyesj	332	34	promise	promise	NN
cord-000248-zueoyesj	332	35	due	due	IN
cord-000248-zueoyesj	332	36	to	to	IN
cord-000248-zueoyesj	332	37	the	the	DT
cord-000248-zueoyesj	332	38	lack	lack	NN
cord-000248-zueoyesj	332	39	of	of	IN
cord-000248-zueoyesj	332	40	a	a	DT
cord-000248-zueoyesj	332	41	reported	report	VBN
cord-000248-zueoyesj	332	42	measurable	measurable	JJ
cord-000248-zueoyesj	332	43	immune	immune	JJ
cord-000248-zueoyesj	332	44	response	response	NN
cord-000248-zueoyesj	332	45	of	of	IN
cord-000248-zueoyesj	332	46	siRNA	siRNA	NNP
cord-000248-zueoyesj	332	47	-	-	HYPH
cord-000248-zueoyesj	332	48	based	base	VBN
cord-000248-zueoyesj	332	49	therapeutics	therapeutic	NNS
cord-000248-zueoyesj	332	50	[	[	-LRB-
cord-000248-zueoyesj	332	51	149	149	CD
cord-000248-zueoyesj	332	52	]	]	-RRB-
cord-000248-zueoyesj	332	53	.	.	.
cord-000248-zueoyesj	333	1	Another	another	DT
cord-000248-zueoyesj	333	2	positive	positive	JJ
cord-000248-zueoyesj	333	3	note	note	NN
cord-000248-zueoyesj	333	4	is	be	VBZ
cord-000248-zueoyesj	333	5	the	the	DT
cord-000248-zueoyesj	333	6	less	less	JJR
cord-000248-zueoyesj	333	7	sensitivity	sensitivity	NN
cord-000248-zueoyesj	333	8	to	to	IN
cord-000248-zueoyesj	333	9	PLK1	plk1	JJ
cord-000248-zueoyesj	333	10	depletion	depletion	NN
cord-000248-zueoyesj	333	11	of	of	IN
cord-000248-zueoyesj	333	12	cells	cell	NNS
cord-000248-zueoyesj	333	13	with	with	IN
cord-000248-zueoyesj	333	14	a	a	DT
cord-000248-zueoyesj	333	15	functional	functional	JJ
cord-000248-zueoyesj	333	16	p53	p53	NN
cord-000248-zueoyesj	333	17	[	[	-LRB-
cord-000248-zueoyesj	333	18	150	150	CD
cord-000248-zueoyesj	333	19	,	,	,
cord-000248-zueoyesj	333	20	151	151	CD
cord-000248-zueoyesj	333	21	]	]	-RRB-
cord-000248-zueoyesj	333	22	,	,	,
cord-000248-zueoyesj	333	23	and	and	CC
cord-000248-zueoyesj	333	24	can	can	MD
cord-000248-zueoyesj	333	25	help	help	VB
cord-000248-zueoyesj	333	26	to	to	TO
cord-000248-zueoyesj	333	27	sensitize	sensitize	VB
cord-000248-zueoyesj	333	28	cells	cell	NNS
cord-000248-zueoyesj	333	29	to	to	IN
cord-000248-zueoyesj	333	30	chemotherapy	chemotherapy	NN
cord-000248-zueoyesj	333	31	(	(	-LRB-
cord-000248-zueoyesj	333	32	as	as	IN
cord-000248-zueoyesj	333	33	observed	observe	VBN
cord-000248-zueoyesj	333	34	in	in	IN
cord-000248-zueoyesj	333	35	lung	lung	NN
cord-000248-zueoyesj	333	36	cancer	cancer	NN
cord-000248-zueoyesj	333	37	[	[	-LRB-
cord-000248-zueoyesj	333	38	152	152	CD
cord-000248-zueoyesj	333	39	]	]	-RRB-
cord-000248-zueoyesj	333	40	)	)	-RRB-
cord-000248-zueoyesj	333	41	.	.	.
cord-000248-zueoyesj	334	1	This	this	DT
cord-000248-zueoyesj	334	2	constraint	constraint	NN
cord-000248-zueoyesj	334	3	of	of	IN
cord-000248-zueoyesj	334	4	aneuploid	aneuploid	JJ
cord-000248-zueoyesj	334	5	cancer	cancer	NN
cord-000248-zueoyesj	334	6	cells	cell	NNS
cord-000248-zueoyesj	334	7	to	to	IN
cord-000248-zueoyesj	334	8	PLK1	plk1	JJ
cord-000248-zueoyesj	334	9	expression	expression	NN
cord-000248-zueoyesj	334	10	,	,	,
cord-000248-zueoyesj	334	11	particularly	particularly	RB
cord-000248-zueoyesj	334	12	in	in	IN
cord-000248-zueoyesj	334	13	cells	cell	NNS
cord-000248-zueoyesj	334	14	with	with	IN
cord-000248-zueoyesj	334	15	inactivated	inactivate	VBN
cord-000248-zueoyesj	334	16	p53	p53	NN
cord-000248-zueoyesj	334	17	[	[	-LRB-
cord-000248-zueoyesj	334	18	153	153	CD
cord-000248-zueoyesj	334	19	]	]	-RRB-
cord-000248-zueoyesj	334	20	,	,	,
cord-000248-zueoyesj	334	21	could	could	MD
cord-000248-zueoyesj	334	22	be	be	VB
cord-000248-zueoyesj	334	23	exploited	exploit	VBN
cord-000248-zueoyesj	334	24	by	by	IN
cord-000248-zueoyesj	334	25	lentivirus	lentivirus	NN
cord-000248-zueoyesj	334	26	-	-	HYPH
cord-000248-zueoyesj	334	27	based	base	VBN
cord-000248-zueoyesj	334	28	RNA	RNA	NNP
cord-000248-zueoyesj	334	29	interference	interference	NN
cord-000248-zueoyesj	334	30	[	[	-LRB-
cord-000248-zueoyesj	334	31	154	154	CD
cord-000248-zueoyesj	334	32	]	]	-RRB-
cord-000248-zueoyesj	334	33	.	.	.
cord-000248-zueoyesj	335	1	Correlation	correlation	NN
cord-000248-zueoyesj	335	2	analysis	analysis	NN
cord-000248-zueoyesj	335	3	with	with	IN
cord-000248-zueoyesj	335	4	Jensen	Jensen	NNP
cord-000248-zueoyesj	335	5	-	-	HYPH
cord-000248-zueoyesj	335	6	Shannon	Shannon	NNP
cord-000248-zueoyesj	335	7	divergences	divergence	NNS
cord-000248-zueoyesj	335	8	reveals	reveal	VBZ
cord-000248-zueoyesj	335	9	biomarkers	biomarker	NNS
cord-000248-zueoyesj	335	10	for	for	IN
cord-000248-zueoyesj	335	11	loss	loss	NN
cord-000248-zueoyesj	335	12	of	of	IN
cord-000248-zueoyesj	335	13	cell	cell	NN
cord-000248-zueoyesj	335	14	adhesion	adhesion	NN
cord-000248-zueoyesj	335	15	,	,	,
cord-000248-zueoyesj	335	16	cell	cell	NN
cord-000248-zueoyesj	335	17	-	-	HYPH
cord-000248-zueoyesj	335	18	cell	cell	NN
cord-000248-zueoyesj	335	19	communication	communication	NN
cord-000248-zueoyesj	335	20	,	,	,
cord-000248-zueoyesj	335	21	impairment	impairment	NN
cord-000248-zueoyesj	335	22	of	of	IN
cord-000248-zueoyesj	335	23	tight	tight	JJ
cord-000248-zueoyesj	335	24	junction	junction	NN
cord-000248-zueoyesj	335	25	mechanisms	mechanism	NNS
cord-000248-zueoyesj	335	26	and	and	CC
cord-000248-zueoyesj	335	27	dysregulation	dysregulation	NN
cord-000248-zueoyesj	335	28	of	of	IN
cord-000248-zueoyesj	335	29	epithelial	epithelial	JJ
cord-000248-zueoyesj	335	30	cell	cell	NN
cord-000248-zueoyesj	335	31	polarity	polarity	NN
cord-000248-zueoyesj	335	32	.	.	.
cord-000248-zueoyesj	336	1	As	as	IN
cord-000248-zueoyesj	336	2	discussed	discuss	VBN
cord-000248-zueoyesj	336	3	before	before	RB
cord-000248-zueoyesj	336	4	,	,	,
cord-000248-zueoyesj	336	5	the	the	DT
cord-000248-zueoyesj	336	6	probe	probe	NN
cord-000248-zueoyesj	336	7	for	for	IN
cord-000248-zueoyesj	336	8	ADA	ADA	NNP
cord-000248-zueoyesj	336	9	(	(	-LRB-
cord-000248-zueoyesj	336	10	Adenosine	adenosine	NN
cord-000248-zueoyesj	336	11	deaminase	deaminase	NNP
cord-000248-zueoyesj	336	12	)	)	-RRB-
cord-000248-zueoyesj	336	13	is	be	VBZ
cord-000248-zueoyesj	336	14	the	the	DT
cord-000248-zueoyesj	336	15	first	first	JJ
cord-000248-zueoyesj	336	16	that	that	WDT
cord-000248-zueoyesj	336	17	has	have	VBZ
cord-000248-zueoyesj	336	18	a	a	DT
cord-000248-zueoyesj	336	19	different	different	JJ
cord-000248-zueoyesj	336	20	trend	trend	NN
cord-000248-zueoyesj	336	21	.	.	.
cord-000248-zueoyesj	337	1	Since	since	IN
cord-000248-zueoyesj	337	2	we	-PRON-	PRP
cord-000248-zueoyesj	337	3	put	put	VBP
cord-000248-zueoyesj	337	4	all	all	DT
cord-000248-zueoyesj	337	5	metastasis	metastasis	NN
cord-000248-zueoyesj	337	6	samples	sample	NNS
cord-000248-zueoyesj	337	7	together	together	RB
cord-000248-zueoyesj	337	8	in	in	IN
cord-000248-zueoyesj	337	9	the	the	DT
cord-000248-zueoyesj	337	10	same	same	JJ
cord-000248-zueoyesj	337	11	group	group	NN
cord-000248-zueoyesj	337	12	when	when	WRB
cord-000248-zueoyesj	337	13	we	-PRON-	PRP
cord-000248-zueoyesj	337	14	calculated	calculate	VBD
cord-000248-zueoyesj	337	15	the	the	DT
cord-000248-zueoyesj	337	16	average	average	JJ
cord-000248-zueoyesj	337	17	probability	probability	NN
cord-000248-zueoyesj	337	18	profile	profile	NN
cord-000248-zueoyesj	337	19	(	(	-LRB-
cord-000248-zueoyesj	337	20	and	and	CC
cord-000248-zueoyesj	337	21	we	-PRON-	PRP
cord-000248-zueoyesj	337	22	have	have	VBP
cord-000248-zueoyesj	337	23	a	a	DT
cord-000248-zueoyesj	337	24	heterogeneous	heterogeneous	JJ
cord-000248-zueoyesj	337	25	group	group	NN
cord-000248-zueoyesj	337	26	)	)	-RRB-
cord-000248-zueoyesj	338	1	we	-PRON-	PRP
cord-000248-zueoyesj	338	2	have	have	VBP
cord-000248-zueoyesj	338	3	on	on	IN
cord-000248-zueoyesj	338	4	our	-PRON-	PRP$
cord-000248-zueoyesj	338	5	ranking	ranking	JJ
cord-000248-zueoyesj	338	6	58	58	CD
cord-000248-zueoyesj	338	7	probes	probe	NNS
cord-000248-zueoyesj	338	8	that	that	WDT
cord-000248-zueoyesj	338	9	appear	appear	VBP
cord-000248-zueoyesj	338	10	before	before	IN
cord-000248-zueoyesj	338	11	ADA	ADA	NNP
cord-000248-zueoyesj	339	1	(	(	-LRB-
cord-000248-zueoyesj	339	2	we	-PRON-	PRP
cord-000248-zueoyesj	339	3	refer	refer	VBP
cord-000248-zueoyesj	339	4	to	to	IN
cord-000248-zueoyesj	339	5	the	the	DT
cord-000248-zueoyesj	339	6	Supplementary	Supplementary	NNP
cord-000248-zueoyesj	339	7	File	File	NNP
cord-000248-zueoyesj	339	8	Haqq-PLoSONE-SupFile.xls	Haqq-PLoSONE-SupFile.xls	NNP
cord-000248-zueoyesj	339	9	)	)	-RRB-
cord-000248-zueoyesj	339	10	.	.	.
cord-000248-zueoyesj	340	1	An	an	DT
cord-000248-zueoyesj	340	2	analysis	analysis	NN
cord-000248-zueoyesj	340	3	using	use	VBG
cord-000248-zueoyesj	340	4	GATHER	gather	VB
cord-000248-zueoyesj	340	5	(	(	-LRB-
cord-000248-zueoyesj	340	6	http://gather.genome.duke.edu/	http://gather.genome.duke.edu/	NNP
cord-000248-zueoyesj	340	7	)	)	-RRB-
cord-000248-zueoyesj	340	8	[	[	-LRB-
cord-000248-zueoyesj	340	9	155	155	CD
cord-000248-zueoyesj	340	10	]	]	-RRB-
cord-000248-zueoyesj	340	11	to	to	TO
cord-000248-zueoyesj	340	12	interpret	interpret	VB
cord-000248-zueoyesj	340	13	the	the	DT
cord-000248-zueoyesj	340	14	collective	collective	JJ
cord-000248-zueoyesj	340	15	influence	influence	NN
cord-000248-zueoyesj	340	16	of	of	IN
cord-000248-zueoyesj	340	17	the	the	DT
cord-000248-zueoyesj	340	18	lack	lack	NN
cord-000248-zueoyesj	340	19	of	of	IN
cord-000248-zueoyesj	340	20	expression	expression	NN
cord-000248-zueoyesj	340	21	of	of	IN
cord-000248-zueoyesj	340	22	all	all	PDT
cord-000248-zueoyesj	340	23	these	these	DT
cord-000248-zueoyesj	340	24	genes	gene	NNS
cord-000248-zueoyesj	340	25	in	in	IN
cord-000248-zueoyesj	340	26	the	the	DT
cord-000248-zueoyesj	340	27	metastasis	metastasis	NN
cord-000248-zueoyesj	340	28	samples	sample	NNS
cord-000248-zueoyesj	340	29	reveals	reveal	VBZ
cord-000248-zueoyesj	340	30	an	an	DT
cord-000248-zueoyesj	340	31	interesting	interesting	JJ
cord-000248-zueoyesj	340	32	new	new	JJ
cord-000248-zueoyesj	340	33	perspective	perspective	NN
cord-000248-zueoyesj	340	34	.	.	.
cord-000248-zueoyesj	341	1	Using	use	VBG
cord-000248-zueoyesj	341	2	Gene	Gene	NNP
cord-000248-zueoyesj	341	3	Ontology	Ontology	NNP
cord-000248-zueoyesj	341	4	,	,	,
cord-000248-zueoyesj	341	5	we	-PRON-	PRP
cord-000248-zueoyesj	341	6	found	find	VBD
cord-000248-zueoyesj	341	7	that	that	IN
cord-000248-zueoyesj	341	8	six	six	CD
cord-000248-zueoyesj	341	9	of	of	IN
cord-000248-zueoyesj	341	10	the	the	DT
cord-000248-zueoyesj	341	11	44	44	CD
cord-000248-zueoyesj	341	12	genes	gene	NNS
cord-000248-zueoyesj	341	13	identified	identify	VBN
cord-000248-zueoyesj	341	14	by	by	IN
cord-000248-zueoyesj	341	15	GATHER	GATHER	NNS
cord-000248-zueoyesj	341	16	are	be	VBP
cord-000248-zueoyesj	341	17	related	relate	VBN
cord-000248-zueoyesj	341	18	to	to	IN
cord-000248-zueoyesj	341	19	epidermis	epidermis	NN
cord-000248-zueoyesj	341	20	development	development	NN
cord-000248-zueoyesj	341	21	(	(	-LRB-
cord-000248-zueoyesj	341	22	CDSN	CDSN	NNP
cord-000248-zueoyesj	341	23	,	,	,
cord-000248-zueoyesj	341	24	DSP	DSP	NNP
cord-000248-zueoyesj	341	25	,	,	,
cord-000248-zueoyesj	341	26	EVPL	EVPL	NNP
cord-000248-zueoyesj	341	27	,	,	,
cord-000248-zueoyesj	341	28	GJB5	GJB5	NNP
cord-000248-zueoyesj	341	29	,	,	,
cord-000248-zueoyesj	341	30	KRT13	KRT13	NNPS
cord-000248-zueoyesj	341	31	,	,	,
cord-000248-zueoyesj	341	32	KRT5	KRT5	NNP
cord-000248-zueoyesj	341	33	)	)	-RRB-
cord-000248-zueoyesj	341	34	,	,	,
cord-000248-zueoyesj	341	35	p	p	NN
cord-000248-zueoyesj	341	36	-	-	HYPH
cord-000248-zueoyesj	341	37	value	value	NN
cord-000248-zueoyesj	341	38	,	,	,
cord-000248-zueoyesj	341	39	0.0001	0.0001	CD
cord-000248-zueoyesj	341	40	,	,	,
cord-000248-zueoyesj	341	41	Bayes	Bayes	NNP
cord-000248-zueoyesj	341	42	Factor	Factor	NNP
cord-000248-zueoyesj	341	43	16	16	CD
cord-000248-zueoyesj	341	44	,	,	,
cord-000248-zueoyesj	341	45	and	and	CC
cord-000248-zueoyesj	341	46	eight	eight	CD
cord-000248-zueoyesj	341	47	genes	gene	NNS
cord-000248-zueoyesj	341	48	are	be	VBP
cord-000248-zueoyesj	341	49	related	relate	VBN
cord-000248-zueoyesj	341	50	to	to	IN
cord-000248-zueoyesj	341	51	cell	cell	NN
cord-000248-zueoyesj	341	52	adhesion	adhesion	NN
cord-000248-zueoyesj	341	53	(	(	-LRB-
cord-000248-zueoyesj	341	54	CDSN	CDSN	NNP
cord-000248-zueoyesj	341	55	,	,	,
cord-000248-zueoyesj	341	56	CLDN1	cldn1	NN
cord-000248-zueoyesj	341	57	,	,	,
cord-000248-zueoyesj	341	58	DSG1	DSG1	NNP
cord-000248-zueoyesj	341	59	,	,	,
cord-000248-zueoyesj	341	60	DST	DST	NNP
cord-000248-zueoyesj	341	61	,	,	,
cord-000248-zueoyesj	341	62	LGALS7	LGALS7	NNP
cord-000248-zueoyesj	341	63	,	,	,
cord-000248-zueoyesj	341	64	LRIG3	LRIG3	NNP
cord-000248-zueoyesj	341	65	,	,	,
cord-000248-zueoyesj	341	66	PCDH21	PCDH21	NNP
cord-000248-zueoyesj	341	67	,	,	,
cord-000248-zueoyesj	341	68	PKP1	PKP1	NNP
cord-000248-zueoyesj	341	69	)	)	-RRB-
cord-000248-zueoyesj	341	70	,	,	,
cord-000248-zueoyesj	341	71	p	p	NN
cord-000248-zueoyesj	341	72	-	-	HYPH
cord-000248-zueoyesj	341	73	value,0.0001	value,0.0001	NNP
cord-000248-zueoyesj	341	74	,	,	,
cord-000248-zueoyesj	341	75	Bayes	Bayes	NNP
cord-000248-zueoyesj	341	76	Factor	Factor	NNP
cord-000248-zueoyesj	341	77	7	7	CD
cord-000248-zueoyesj	341	78	.	.	.
cord-000248-zueoyesj	342	1	ANK1	ank1	DT
cord-000248-zueoyesj	342	2	(	(	-LRB-
cord-000248-zueoyesj	342	3	Ankyrin	Ankyrin	NNP
cord-000248-zueoyesj	342	4	1	1	CD
cord-000248-zueoyesj	342	5	,	,	,
cord-000248-zueoyesj	342	6	erythrocytic	erythrocytic	NNP
cord-000248-zueoyesj	342	7	)	)	-RRB-
cord-000248-zueoyesj	342	8	,	,	,
cord-000248-zueoyesj	342	9	AA464755	AA464755	NNP
cord-000248-zueoyesj	342	10	was	be	VBD
cord-000248-zueoyesj	342	11	also	also	RB
cord-000248-zueoyesj	342	12	singled	single	VBN
cord-000248-zueoyesj	342	13	out	out	RP
cord-000248-zueoyesj	342	14	as	as	IN
cord-000248-zueoyesj	342	15	by	by	IN
cord-000248-zueoyesj	342	16	our	-PRON-	PRP$
cord-000248-zueoyesj	342	17	Gene	Gene	NNP
cord-000248-zueoyesj	342	18	Ontology	Ontology	NNP
cord-000248-zueoyesj	342	19	analysis	analysis	NN
cord-000248-zueoyesj	342	20	as	as	IN
cord-000248-zueoyesj	342	21	related	relate	VBN
cord-000248-zueoyesj	342	22	to	to	IN
cord-000248-zueoyesj	342	23	the	the	DT
cord-000248-zueoyesj	342	24	maintenance	maintenance	NN
cord-000248-zueoyesj	342	25	of	of	IN
cord-000248-zueoyesj	342	26	epithelial	epithelial	JJ
cord-000248-zueoyesj	342	27	cell	cell	NN
cord-000248-zueoyesj	342	28	polarity	polarity	NN
cord-000248-zueoyesj	342	29	(	(	-LRB-
cord-000248-zueoyesj	342	30	p	p	NN
cord-000248-zueoyesj	342	31	-	-	HYPH
cord-000248-zueoyesj	342	32	value	value	NN
cord-000248-zueoyesj	342	33	=	=	SYM
cord-000248-zueoyesj	342	34	0.002	0.002	CD
cord-000248-zueoyesj	342	35	,	,	,
cord-000248-zueoyesj	342	36	Bayes	Bayes	NNP
cord-000248-zueoyesj	342	37	Factor	Factor	NNP
cord-000248-zueoyesj	342	38	3	3	CD
cord-000248-zueoyesj	342	39	)	)	-RRB-
cord-000248-zueoyesj	342	40	.	.	.
cord-000248-zueoyesj	343	1	The	the	DT
cord-000248-zueoyesj	343	2	use	use	NN
cord-000248-zueoyesj	343	3	of	of	IN
cord-000248-zueoyesj	343	4	another	another	DT
cord-000248-zueoyesj	343	5	profiler	profiler	NN
cord-000248-zueoyesj	343	6	of	of	IN
cord-000248-zueoyesj	343	7	genome	genome	NN
cord-000248-zueoyesj	343	8	signatures	signature	NNS
cord-000248-zueoyesj	343	9	(	(	-LRB-
cord-000248-zueoyesj	343	10	g	g	NN
cord-000248-zueoyesj	343	11	:	:	:
cord-000248-zueoyesj	343	12	Profiler	profiler	NN
cord-000248-zueoyesj	343	13	,	,	,
cord-000248-zueoyesj	343	14	[	[	-LRB-
cord-000248-zueoyesj	343	15	156	156	CD
cord-000248-zueoyesj	343	16	]	]	-RRB-
cord-000248-zueoyesj	343	17	)	)	-RRB-
cord-000248-zueoyesj	343	18	also	also	RB
cord-000248-zueoyesj	343	19	reinforces	reinforce	VBZ
cord-000248-zueoyesj	343	20	the	the	DT
cord-000248-zueoyesj	343	21	view	view	NN
cord-000248-zueoyesj	343	22	that	that	IN
cord-000248-zueoyesj	343	23	many	many	JJ
cord-000248-zueoyesj	343	24	genes	gene	NNS
cord-000248-zueoyesj	343	25	that	that	WDT
cord-000248-zueoyesj	343	26	have	have	VBP
cord-000248-zueoyesj	343	27	lost	lose	VBN
cord-000248-zueoyesj	343	28	expression	expression	NN
cord-000248-zueoyesj	343	29	are	be	VBP
cord-000248-zueoyesj	343	30	related	relate	VBN
cord-000248-zueoyesj	343	31	to	to	IN
cord-000248-zueoyesj	343	32	'	'	``
cord-000248-zueoyesj	343	33	Epidermis	Epidermis	NNP
cord-000248-zueoyesj	343	34	Development	Development	NNP
cord-000248-zueoyesj	343	35	'	'	''
cord-000248-zueoyesj	343	36	(	(	-LRB-
cord-000248-zueoyesj	343	37	COL17A1	COL17A1	NNP
cord-000248-zueoyesj	343	38	,	,	,
cord-000248-zueoyesj	343	39	DSP	DSP	NNP
cord-000248-zueoyesj	343	40	,	,	,
cord-000248-zueoyesj	343	41	EVPL	EVPL	NNP
cord-000248-zueoyesj	343	42	,	,	,
cord-000248-zueoyesj	343	43	GJB5	GJB5	NNP
cord-000248-zueoyesj	343	44	,	,	,
cord-000248-zueoyesj	343	45	KRT13	KRT13	NNPS
cord-000248-zueoyesj	343	46	,	,	,
cord-000248-zueoyesj	343	47	KRT5	KRT5	NNP
cord-000248-zueoyesj	343	48	,	,	,
cord-000248-zueoyesj	343	49	LCE1C	LCE1C	NNS
cord-000248-zueoyesj	343	50	,	,	,
cord-000248-zueoyesj	343	51	MAFG	MAFG	NNP
cord-000248-zueoyesj	343	52	,	,	,
cord-000248-zueoyesj	343	53	TGM3	TGM3	NNP
cord-000248-zueoyesj	343	54	)	)	-RRB-
cord-000248-zueoyesj	343	55	with	with	IN
cord-000248-zueoyesj	343	56	p	p	NN
cord-000248-zueoyesj	343	57	-	-	HYPH
cord-000248-zueoyesj	343	58	value	value	NN
cord-000248-zueoyesj	343	59	=	=	NFP
cord-000248-zueoyesj	343	60	7.78E-11	7.78e-11	CD
cord-000248-zueoyesj	343	61	.	.	.
cord-000248-zueoyesj	344	1	Thirteen	thirteen	CD
cord-000248-zueoyesj	344	2	are	be	VBP
cord-000248-zueoyesj	344	3	associated	associate	VBN
cord-000248-zueoyesj	344	4	with	with	IN
cord-000248-zueoyesj	344	5	Gene	Gene	NNP
cord-000248-zueoyesj	344	6	Ontology	Ontology	NNP
cord-000248-zueoyesj	344	7	function	function	NN
cord-000248-zueoyesj	344	8	of	of	IN
cord-000248-zueoyesj	344	9	cell	cell	NN
cord-000248-zueoyesj	344	10	communication	communication	NN
cord-000248-zueoyesj	344	11	(	(	-LRB-
cord-000248-zueoyesj	344	12	ANK1	ANK1	NNP
cord-000248-zueoyesj	344	13	,	,	,
cord-000248-zueoyesj	344	14	CDSN	CDSN	NNP
cord-000248-zueoyesj	344	15	,	,	,
cord-000248-zueoyesj	344	16	CLDN1	CLDN1	NNP
cord-000248-zueoyesj	344	17	,	,	,
cord-000248-zueoyesj	344	18	DSG1	DSG1	NNP
cord-000248-zueoyesj	344	19	,	,	,
cord-000248-zueoyesj	344	20	DST	DST	NNP
cord-000248-zueoyesj	344	21	,	,	,
cord-000248-zueoyesj	344	22	GCHFR	GCHFR	NNP
cord-000248-zueoyesj	344	23	,	,	,
cord-000248-zueoyesj	344	24	GJB5	GJB5	NNP
cord-000248-zueoyesj	344	25	,	,	,
cord-000248-zueoyesj	344	26	GPR115	GPR115	NNP
cord-000248-zueoyesj	344	27	,	,	,
cord-000248-zueoyesj	344	28	LGALS7	LGALS7	NNP
cord-000248-zueoyesj	344	29	,	,	,
cord-000248-zueoyesj	344	30	LRIG3	LRIG3	NNP
cord-000248-zueoyesj	344	31	,	,	.
cord-000248-zueoyesj	345	1	PCDH21	PCDH21	NNP
cord-000248-zueoyesj	345	2	,	,	,
cord-000248-zueoyesj	345	3	PKP1	PKP1	NNP
cord-000248-zueoyesj	345	4	,	,	,
cord-000248-zueoyesj	345	5	PTGER3	PTGER3	NNP
cord-000248-zueoyesj	345	6	)	)	-RRB-
cord-000248-zueoyesj	345	7	,	,	,
cord-000248-zueoyesj	345	8	albeit	albeit	IN
cord-000248-zueoyesj	345	9	with	with	IN
cord-000248-zueoyesj	345	10	a	a	DT
cord-000248-zueoyesj	345	11	pvalue	pvalue	NN
cord-000248-zueoyesj	345	12	of	of	IN
cord-000248-zueoyesj	345	13	only	only	RB
cord-000248-zueoyesj	345	14	0.02	0.02	CD
cord-000248-zueoyesj	345	15	.	.	.
cord-000248-zueoyesj	346	1	GCHFR	GCHFR	NNP
cord-000248-zueoyesj	346	2	is	be	VBZ
cord-000248-zueoyesj	346	3	also	also	RB
cord-000248-zueoyesj	346	4	involved	involve	VBN
cord-000248-zueoyesj	346	5	in	in	IN
cord-000248-zueoyesj	346	6	nitric	nitric	JJ
cord-000248-zueoyesj	346	7	oxide	oxide	NN
cord-000248-zueoyesj	346	8	metabolism	metabolism	NN
cord-000248-zueoyesj	346	9	.	.	.
cord-000248-zueoyesj	347	1	If	if	IN
cord-000248-zueoyesj	347	2	we	-PRON-	PRP
cord-000248-zueoyesj	347	3	add	add	VBP
cord-000248-zueoyesj	347	4	to	to	IN
cord-000248-zueoyesj	347	5	the	the	DT
cord-000248-zueoyesj	347	6	list	list	NN
cord-000248-zueoyesj	347	7	of	of	IN
cord-000248-zueoyesj	347	8	44	44	CD
cord-000248-zueoyesj	347	9	genes	gene	NNS
cord-000248-zueoyesj	347	10	already	already	RB
cord-000248-zueoyesj	347	11	recognized	recognize	VBN
cord-000248-zueoyesj	347	12	by	by	IN
cord-000248-zueoyesj	347	13	GATHER	gather	VB
cord-000248-zueoyesj	347	14	the	the	DT
cord-000248-zueoyesj	347	15	other	other	JJ
cord-000248-zueoyesj	347	16	77	77	CD
cord-000248-zueoyesj	347	17	probes	probe	NNS
cord-000248-zueoyesj	347	18	that	that	WDT
cord-000248-zueoyesj	347	19	after	after	IN
cord-000248-zueoyesj	347	20	ADA	ADA	NNP
cord-000248-zueoyesj	347	21	in	in	IN
cord-000248-zueoyesj	347	22	this	this	DT
cord-000248-zueoyesj	347	23	ranking	ranking	NN
cord-000248-zueoyesj	347	24	have	have	VBP
cord-000248-zueoyesj	347	25	also	also	RB
cord-000248-zueoyesj	347	26	loss	loss	NN
cord-000248-zueoyesj	347	27	of	of	IN
cord-000248-zueoyesj	347	28	expression	expression	NN
cord-000248-zueoyesj	347	29	(	(	-LRB-
cord-000248-zueoyesj	347	30	until	until	IN
cord-000248-zueoyesj	347	31	we	-PRON-	PRP
cord-000248-zueoyesj	347	32	found	find	VBD
cord-000248-zueoyesj	347	33	PDXP	PDXP	NNP
cord-000248-zueoyesj	347	34	(	(	-LRB-
cord-000248-zueoyesj	347	35	Pyridoxal	Pyridoxal	NNP
cord-000248-zueoyesj	347	36	(	(	-LRB-
cord-000248-zueoyesj	347	37	pyridoxine	pyridoxine	NN
cord-000248-zueoyesj	347	38	,	,	,
cord-000248-zueoyesj	347	39	vitamin	vitamin	NN
cord-000248-zueoyesj	347	40	B6	b6	NN
cord-000248-zueoyesj	347	41	)	)	-RRB-
cord-000248-zueoyesj	347	42	phosphatase	phosphatase	NN
cord-000248-zueoyesj	347	43	)	)	-RRB-
cord-000248-zueoyesj	347	44	,	,	,
cord-000248-zueoyesj	347	45	the	the	DT
cord-000248-zueoyesj	347	46	evidence	evidence	NN
cord-000248-zueoyesj	347	47	is	be	VBZ
cord-000248-zueoyesj	347	48	stronger	strong	JJR
cord-000248-zueoyesj	347	49	,	,	,
cord-000248-zueoyesj	347	50	now	now	RB
cord-000248-zueoyesj	347	51	COL7A1	COL7A1	NNP
cord-000248-zueoyesj	347	52	,	,	,
cord-000248-zueoyesj	347	53	GJB5	GJB5	NNP
cord-000248-zueoyesj	347	54	,	,	,
cord-000248-zueoyesj	347	55	KLK4	KLK4	NNP
cord-000248-zueoyesj	347	56	,	,	,
cord-000248-zueoyesj	347	57	and	and	CC
cord-000248-zueoyesj	347	58	KRT1	KRT1	NNP
cord-000248-zueoyesj	347	59	also	also	RB
cord-000248-zueoyesj	347	60	is	be	VBZ
cord-000248-zueoyesj	347	61	in	in	IN
cord-000248-zueoyesj	347	62	this	this	DT
cord-000248-zueoyesj	347	63	group	group	NN
cord-000248-zueoyesj	347	64	(	(	-LRB-
cord-000248-zueoyesj	347	65	the	the	DT
cord-000248-zueoyesj	347	66	Bayes	Bayes	NNP
cord-000248-zueoyesj	347	67	factor	factor	NN
cord-000248-zueoyesj	347	68	of	of	IN
cord-000248-zueoyesj	347	69	this	this	DT
cord-000248-zueoyesj	347	70	association	association	NN
cord-000248-zueoyesj	347	71	returned	return	VBD
cord-000248-zueoyesj	347	72	by	by	IN
cord-000248-zueoyesj	347	73	Gather	Gather	NNP
cord-000248-zueoyesj	347	74	is	be	VBZ
cord-000248-zueoyesj	347	75	now	now	RB
cord-000248-zueoyesj	347	76	21	21	CD
cord-000248-zueoyesj	347	77	for	for	IN
cord-000248-zueoyesj	347	78	the	the	DT
cord-000248-zueoyesj	347	79	GO	GO	NNP
cord-000248-zueoyesj	347	80	term	term	NN
cord-000248-zueoyesj	347	81	'	'	``
cord-000248-zueoyesj	347	82	Epidermis	epidermis	NN
cord-000248-zueoyesj	347	83	development	development	NN
cord-000248-zueoyesj	347	84	'	'	''
cord-000248-zueoyesj	347	85	)	)	-RRB-
cord-000248-zueoyesj	347	86	.	.	.
cord-000248-zueoyesj	347	87	'	'	''
cord-000248-zueoyesj	348	1	Cell	cell	NN
cord-000248-zueoyesj	348	2	adhesion	adhesion	NN
cord-000248-zueoyesj	348	3	'	'	''
cord-000248-zueoyesj	348	4	has	have	VBZ
cord-000248-zueoyesj	348	5	now	now	RB
cord-000248-zueoyesj	348	6	13	13	CD
cord-000248-zueoyesj	348	7	genes	gene	NNS
cord-000248-zueoyesj	348	8	,	,	,
cord-000248-zueoyesj	348	9	CDSN	CDSN	NNP
cord-000248-zueoyesj	348	10	,	,	,
cord-000248-zueoyesj	348	11	CLDN1	cldn1	NN
cord-000248-zueoyesj	348	12	,	,	,
cord-000248-zueoyesj	348	13	COL7A1	COL7A1	NNP
cord-000248-zueoyesj	348	14	,	,	,
cord-000248-zueoyesj	348	15	DSC2	DSC2	NNP
cord-000248-zueoyesj	348	16	,	,	,
cord-000248-zueoyesj	348	17	DSG1	DSG1	NNP
cord-000248-zueoyesj	348	18	,	,	,
cord-000248-zueoyesj	348	19	DST	DST	NNP
cord-000248-zueoyesj	348	20	,	,	,
cord-000248-zueoyesj	348	21	JUP	JUP	NNP
cord-000248-zueoyesj	348	22	,	,	,
cord-000248-zueoyesj	348	23	LGALS7	LGALS7	NNP
cord-000248-zueoyesj	348	24	,	,	,
cord-000248-zueoyesj	348	25	LRIG3	LRIG3	NNP
cord-000248-zueoyesj	348	26	,	,	,
cord-000248-zueoyesj	348	27	PCDH21	PCDH21	NNP
cord-000248-zueoyesj	348	28	,	,	,
cord-000248-zueoyesj	348	29	PKP1	PKP1	NNP
cord-000248-zueoyesj	348	30	,	,	,
cord-000248-zueoyesj	349	1	SLIT3	SLIT3	.
cord-000248-zueoyesj	350	1	THBS3	THBS3	NNP
cord-000248-zueoyesj	351	1	(	(	-LRB-
cord-000248-zueoyesj	351	2	p	p	NN
cord-000248-zueoyesj	351	3	-	-	HYPH
cord-000248-zueoyesj	351	4	value,0.001	value,0.001	NNP
cord-000248-zueoyesj	351	5	,	,	,
cord-000248-zueoyesj	351	6	Bayes	Bayes	NNP
cord-000248-zueoyesj	351	7	factor	factor	NN
cord-000248-zueoyesj	351	8	10	10	CD
cord-000248-zueoyesj	351	9	)	)	-RRB-
cord-000248-zueoyesj	351	10	.	.	.
cord-000248-zueoyesj	352	1	These	these	DT
cord-000248-zueoyesj	352	2	results	result	NNS
cord-000248-zueoyesj	352	3	are	be	VBP
cord-000248-zueoyesj	352	4	considered	consider	VBN
cord-000248-zueoyesj	352	5	statistically	statistically	RB
cord-000248-zueoyesj	352	6	very	very	RB
cord-000248-zueoyesj	352	7	relevant	relevant	JJ
cord-000248-zueoyesj	352	8	as	as	IN
cord-000248-zueoyesj	352	9	identifiers	identifier	NNS
cord-000248-zueoyesj	352	10	of	of	IN
cord-000248-zueoyesj	352	11	a	a	DT
cord-000248-zueoyesj	352	12	particular	particular	JJ
cord-000248-zueoyesj	352	13	process	process	NN
cord-000248-zueoyesj	352	14	which	which	WDT
cord-000248-zueoyesj	352	15	seems	seem	VBZ
cord-000248-zueoyesj	352	16	to	to	TO
cord-000248-zueoyesj	352	17	be	be	VB
cord-000248-zueoyesj	352	18	undermined	undermine	VBN
cord-000248-zueoyesj	352	19	by	by	IN
cord-000248-zueoyesj	352	20	this	this	DT
cord-000248-zueoyesj	352	21	collective	collective	JJ
cord-000248-zueoyesj	352	22	loss	loss	NN
cord-000248-zueoyesj	352	23	of	of	IN
cord-000248-zueoyesj	352	24	expression	expression	NN
cord-000248-zueoyesj	352	25	.	.	.
cord-000248-zueoyesj	353	1	If	if	IN
cord-000248-zueoyesj	353	2	we	-PRON-	PRP
cord-000248-zueoyesj	353	3	put	put	VBP
cord-000248-zueoyesj	353	4	all	all	PDT
cord-000248-zueoyesj	353	5	this	this	DT
cord-000248-zueoyesj	353	6	information	information	NN
cord-000248-zueoyesj	353	7	together	together	RB
cord-000248-zueoyesj	353	8	,	,	,
cord-000248-zueoyesj	353	9	we	-PRON-	PRP
cord-000248-zueoyesj	353	10	clearly	clearly	RB
cord-000248-zueoyesj	353	11	observe	observe	VBP
cord-000248-zueoyesj	353	12	a	a	DT
cord-000248-zueoyesj	353	13	pattern	pattern	NN
cord-000248-zueoyesj	353	14	of	of	IN
cord-000248-zueoyesj	353	15	downregulation	downregulation	NN
cord-000248-zueoyesj	353	16	of	of	IN
cord-000248-zueoyesj	353	17	gene	gene	NN
cord-000248-zueoyesj	353	18	expression	expression	NN
cord-000248-zueoyesj	353	19	that	that	WDT
cord-000248-zueoyesj	353	20	is	be	VBZ
cord-000248-zueoyesj	353	21	associated	associate	VBN
cord-000248-zueoyesj	353	22	with	with	IN
cord-000248-zueoyesj	353	23	an	an	DT
cord-000248-zueoyesj	353	24	impairment	impairment	NN
cord-000248-zueoyesj	353	25	of	of	IN
cord-000248-zueoyesj	353	26	epidermis	epidermis	NN
cord-000248-zueoyesj	353	27	development	development	NN
cord-000248-zueoyesj	353	28	and	and	CC
cord-000248-zueoyesj	353	29	the	the	DT
cord-000248-zueoyesj	353	30	maintainance	maintainance	NN
cord-000248-zueoyesj	353	31	of	of	IN
cord-000248-zueoyesj	353	32	its	-PRON-	PRP$
cord-000248-zueoyesj	353	33	structure	structure	NN
cord-000248-zueoyesj	353	34	(	(	-LRB-
cord-000248-zueoyesj	353	35	Figure	Figure	NNP
cord-000248-zueoyesj	353	36	8	8	CD
cord-000248-zueoyesj	353	37	and	and	CC
cord-000248-zueoyesj	353	38	Table	Table	NNP
cord-000248-zueoyesj	353	39	1	1	CD
cord-000248-zueoyesj	353	40	)	)	-RRB-
cord-000248-zueoyesj	353	41	.	.	.
cord-000248-zueoyesj	354	1	This	this	DT
cord-000248-zueoyesj	354	2	is	be	VBZ
cord-000248-zueoyesj	354	3	,	,	,
cord-000248-zueoyesj	354	4	perhaps	perhaps	RB
cord-000248-zueoyesj	354	5	,	,	,
cord-000248-zueoyesj	354	6	an	an	DT
cord-000248-zueoyesj	354	7	instantiation	instantiation	NN
cord-000248-zueoyesj	354	8	of	of	IN
cord-000248-zueoyesj	354	9	one	one	CD
cord-000248-zueoyesj	354	10	of	of	IN
cord-000248-zueoyesj	354	11	the	the	DT
cord-000248-zueoyesj	354	12	'	'	''
cord-000248-zueoyesj	354	13	'	'	``
cord-000248-zueoyesj	354	14	extended	extend	VBN
cord-000248-zueoyesj	354	15	hallmarks	hallmark	NNS
cord-000248-zueoyesj	354	16	of	of	IN
cord-000248-zueoyesj	354	17	cancer	cancer	NN
cord-000248-zueoyesj	354	18	'	'	''
cord-000248-zueoyesj	354	19	'	'	''
cord-000248-zueoyesj	355	1	(	(	-LRB-
cord-000248-zueoyesj	355	2	that	that	DT
cord-000248-zueoyesj	355	3	of	of	IN
cord-000248-zueoyesj	355	4	'	'	``
cord-000248-zueoyesj	355	5	'	'	''
cord-000248-zueoyesj	355	6	tissue	tissue	NN
cord-000248-zueoyesj	355	7	dedifferentiation	dedifferentiation	NN
cord-000248-zueoyesj	355	8	'	'	''
cord-000248-zueoyesj	355	9	'	'	''
cord-000248-zueoyesj	355	10	)	)	-RRB-
cord-000248-zueoyesj	355	11	.	.	.
cord-000248-zueoyesj	356	1	This	this	DT
cord-000248-zueoyesj	356	2	process	process	NN
cord-000248-zueoyesj	356	3	includes	include	VBZ
cord-000248-zueoyesj	356	4	the	the	DT
cord-000248-zueoyesj	356	5	loss	loss	NN
cord-000248-zueoyesj	356	6	of	of	IN
cord-000248-zueoyesj	356	7	function	function	NN
cord-000248-zueoyesj	356	8	of	of	IN
cord-000248-zueoyesj	356	9	genes	gene	NNS
cord-000248-zueoyesj	356	10	that	that	WDT
cord-000248-zueoyesj	356	11	are	be	VBP
cord-000248-zueoyesj	356	12	essential	essential	JJ
cord-000248-zueoyesj	356	13	for	for	IN
cord-000248-zueoyesj	356	14	the	the	DT
cord-000248-zueoyesj	356	15	maitainance	maitainance	NN
cord-000248-zueoyesj	356	16	of	of	IN
cord-000248-zueoyesj	356	17	tight	tight	JJ
cord-000248-zueoyesj	356	18	junction	junction	NN
cord-000248-zueoyesj	356	19	and	and	CC
cord-000248-zueoyesj	356	20	epithelial	epithelial	JJ
cord-000248-zueoyesj	356	21	cell	cell	NN
cord-000248-zueoyesj	356	22	-	-	HYPH
cord-000248-zueoyesj	356	23	cell	cell	NN
cord-000248-zueoyesj	356	24	communication	communication	NN
cord-000248-zueoyesj	356	25	.	.	.
cord-000248-zueoyesj	357	1	While	while	IN
cord-000248-zueoyesj	357	2	loss	loss	NN
cord-000248-zueoyesj	357	3	of	of	IN
cord-000248-zueoyesj	357	4	epithelial	epithelial	JJ
cord-000248-zueoyesj	357	5	structure	structure	NN
cord-000248-zueoyesj	357	6	is	be	VBZ
cord-000248-zueoyesj	357	7	related	relate	VBN
cord-000248-zueoyesj	357	8	to	to	IN
cord-000248-zueoyesj	357	9	these	these	DT
cord-000248-zueoyesj	357	10	genes	gene	NNS
cord-000248-zueoyesj	357	11	,	,	,
cord-000248-zueoyesj	357	12	we	-PRON-	PRP
cord-000248-zueoyesj	357	13	observe	observe	VBP
cord-000248-zueoyesj	357	14	that	that	IN
cord-000248-zueoyesj	357	15	those	those	DT
cord-000248-zueoyesj	357	16	that	that	WDT
cord-000248-zueoyesj	357	17	increase	increase	VBP
cord-000248-zueoyesj	357	18	expression	expression	NN
cord-000248-zueoyesj	357	19	are	be	VBP
cord-000248-zueoyesj	357	20	associated	associate	VBN
cord-000248-zueoyesj	357	21	to	to	IN
cord-000248-zueoyesj	357	22	other	other	JJ
cord-000248-zueoyesj	357	23	developmental	developmental	JJ
cord-000248-zueoyesj	357	24	processes	process	NNS
cord-000248-zueoyesj	357	25	,	,	,
cord-000248-zueoyesj	357	26	not	not	RB
cord-000248-zueoyesj	357	27	necessarily	necessarily	RB
cord-000248-zueoyesj	357	28	concerted	concert	VBN
cord-000248-zueoyesj	357	29	in	in	IN
cord-000248-zueoyesj	357	30	this	this	DT
cord-000248-zueoyesj	357	31	panel	panel	NN
cord-000248-zueoyesj	357	32	.	.	.
cord-000248-zueoyesj	358	1	Instead	instead	RB
cord-000248-zueoyesj	358	2	they	-PRON-	PRP
cord-000248-zueoyesj	358	3	show	show	VBP
cord-000248-zueoyesj	358	4	a	a	DT
cord-000248-zueoyesj	358	5	pattern	pattern	NN
cord-000248-zueoyesj	358	6	of	of	IN
cord-000248-zueoyesj	358	7	increasing	increase	VBG
cord-000248-zueoyesj	358	8	cell	cell	NN
cord-000248-zueoyesj	358	9	motility	motility	NN
cord-000248-zueoyesj	358	10	,	,	,
cord-000248-zueoyesj	358	11	chemotaxis	chemotaxis	NN
cord-000248-zueoyesj	358	12	and	and	CC
cord-000248-zueoyesj	358	13	positive	positive	JJ
cord-000248-zueoyesj	358	14	regulation	regulation	NN
cord-000248-zueoyesj	358	15	of	of	IN
cord-000248-zueoyesj	358	16	cell	cell	NN
cord-000248-zueoyesj	358	17	proliferation	proliferation	NN
cord-000248-zueoyesj	358	18	.	.	.
cord-000248-zueoyesj	359	1	We	-PRON-	PRP
cord-000248-zueoyesj	359	2	will	will	MD
cord-000248-zueoyesj	359	3	first	first	RB
cord-000248-zueoyesj	359	4	discuss	discuss	VB
cord-000248-zueoyesj	359	5	the	the	DT
cord-000248-zueoyesj	359	6	processes	process	NNS
cord-000248-zueoyesj	359	7	related	relate	VBN
cord-000248-zueoyesj	359	8	to	to	IN
cord-000248-zueoyesj	359	9	the	the	DT
cord-000248-zueoyesj	359	10	loss	loss	NN
cord-000248-zueoyesj	359	11	of	of	IN
cord-000248-zueoyesj	359	12	adhesion	adhesion	NN
cord-000248-zueoyesj	359	13	,	,	,
cord-000248-zueoyesj	359	14	which	which	WDT
cord-000248-zueoyesj	359	15	could	could	MD
cord-000248-zueoyesj	359	16	be	be	VB
cord-000248-zueoyesj	359	17	linked	link	VBN
cord-000248-zueoyesj	359	18	to	to	IN
cord-000248-zueoyesj	359	19	an	an	DT
cord-000248-zueoyesj	359	20	increased	increase	VBN
cord-000248-zueoyesj	359	21	probability	probability	NN
cord-000248-zueoyesj	359	22	of	of	IN
cord-000248-zueoyesj	359	23	metastatic	metastatic	JJ
cord-000248-zueoyesj	359	24	potential	potential	NN
cord-000248-zueoyesj	359	25	of	of	IN
cord-000248-zueoyesj	359	26	these	these	DT
cord-000248-zueoyesj	359	27	cells	cell	NNS
cord-000248-zueoyesj	359	28	.	.	.
cord-000248-zueoyesj	360	1	The	the	DT
cord-000248-zueoyesj	360	2	loss	loss	NN
cord-000248-zueoyesj	360	3	of	of	IN
cord-000248-zueoyesj	360	4	expression	expression	NN
cord-000248-zueoyesj	360	5	of	of	IN
cord-000248-zueoyesj	360	6	Plakophilin	Plakophilin	NNP
cord-000248-zueoyesj	360	7	1	1	CD
cord-000248-zueoyesj	360	8	,	,	,
cord-000248-zueoyesj	360	9	Junction	Junction	NNP
cord-000248-zueoyesj	360	10	plakoglobin	plakoglobin	NN
cord-000248-zueoyesj	360	11	,	,	,
cord-000248-zueoyesj	360	12	Desmoplakin	Desmoplakin	NNP
cord-000248-zueoyesj	360	13	and	and	CC
cord-000248-zueoyesj	360	14	Desmoglein	Desmoglein	NNP
cord-000248-zueoyesj	360	15	1	1	CD
cord-000248-zueoyesj	360	16	indicate	indicate	VBP
cord-000248-zueoyesj	360	17	deficiencies	deficiency	NNS
cord-000248-zueoyesj	360	18	in	in	IN
cord-000248-zueoyesj	360	19	desmosome	desmosome	NN
cord-000248-zueoyesj	360	20	processes	process	NNS
cord-000248-zueoyesj	360	21	.	.	.
cord-000248-zueoyesj	361	1	In	in	IN
cord-000248-zueoyesj	361	2	general	general	JJ
cord-000248-zueoyesj	361	3	,	,	,
cord-000248-zueoyesj	361	4	this	this	DT
cord-000248-zueoyesj	361	5	panel	panel	NN
cord-000248-zueoyesj	361	6	is	be	VBZ
cord-000248-zueoyesj	361	7	composed	compose	VBN
cord-000248-zueoyesj	361	8	of	of	IN
cord-000248-zueoyesj	361	9	a	a	DT
cord-000248-zueoyesj	361	10	number	number	NN
cord-000248-zueoyesj	361	11	of	of	IN
cord-000248-zueoyesj	361	12	genes	gene	NNS
cord-000248-zueoyesj	361	13	that	that	WDT
cord-000248-zueoyesj	361	14	are	be	VBP
cord-000248-zueoyesj	361	15	losing	lose	VBG
cord-000248-zueoyesj	361	16	expression	expression	NN
cord-000248-zueoyesj	361	17	during	during	IN
cord-000248-zueoyesj	361	18	progression	progression	NN
cord-000248-zueoyesj	361	19	and	and	CC
cord-000248-zueoyesj	361	20	that	that	WDT
cord-000248-zueoyesj	361	21	have	have	VBP
cord-000248-zueoyesj	361	22	Gene	Gene	NNP
cord-000248-zueoyesj	361	23	Ontology	Ontology	NNP
cord-000248-zueoyesj	361	24	annotations	annotation	NNS
cord-000248-zueoyesj	361	25	related	relate	VBN
cord-000248-zueoyesj	361	26	to	to	IN
cord-000248-zueoyesj	361	27	tight	tight	JJ
cord-000248-zueoyesj	361	28	junctions	junction	NNS
cord-000248-zueoyesj	361	29	,	,	,
cord-000248-zueoyesj	361	30	gap	gap	NN
cord-000248-zueoyesj	361	31	junctions	junction	NNS
cord-000248-zueoyesj	361	32	,	,	,
cord-000248-zueoyesj	361	33	adherens	adheren	NNS
cord-000248-zueoyesj	361	34	junctions	junction	NNS
cord-000248-zueoyesj	361	35	and	and	CC
cord-000248-zueoyesj	361	36	desmosomes	desmosome	NNS
cord-000248-zueoyesj	361	37	,	,	,
cord-000248-zueoyesj	361	38	and	and	CC
cord-000248-zueoyesj	361	39	an	an	DT
cord-000248-zueoyesj	361	40	impaired	impaired	JJ
cord-000248-zueoyesj	361	41	set	set	NN
cord-000248-zueoyesj	361	42	of	of	IN
cord-000248-zueoyesj	361	43	processes	process	NNS
cord-000248-zueoyesj	361	44	that	that	WDT
cord-000248-zueoyesj	361	45	link	link	VBP
cord-000248-zueoyesj	361	46	,	,	,
cord-000248-zueoyesj	361	47	via	via	IN
cord-000248-zueoyesj	361	48	intercellular	intercellular	JJ
cord-000248-zueoyesj	361	49	channels	channel	NNS
cord-000248-zueoyesj	361	50	and	and	CC
cord-000248-zueoyesj	361	51	bridges	bridge	NNS
cord-000248-zueoyesj	361	52	,	,	,
cord-000248-zueoyesj	361	53	the	the	DT
cord-000248-zueoyesj	361	54	cells	cell	NNS
cord-000248-zueoyesj	361	55	of	of	IN
cord-000248-zueoyesj	361	56	the	the	DT
cord-000248-zueoyesj	361	57	epidermis	epidermis	NN
cord-000248-zueoyesj	361	58	.	.	.
cord-000248-zueoyesj	362	1	Mutations	mutation	NNS
cord-000248-zueoyesj	362	2	in	in	IN
cord-000248-zueoyesj	362	3	these	these	DT
cord-000248-zueoyesj	362	4	genes	gene	NNS
cord-000248-zueoyesj	362	5	are	be	VBP
cord-000248-zueoyesj	362	6	linked	link	VBN
cord-000248-zueoyesj	362	7	to	to	IN
cord-000248-zueoyesj	362	8	a	a	DT
cord-000248-zueoyesj	362	9	number	number	NN
cord-000248-zueoyesj	362	10	of	of	IN
cord-000248-zueoyesj	362	11	skin	skin	NN
cord-000248-zueoyesj	362	12	genetic	genetic	JJ
cord-000248-zueoyesj	362	13	diseases	disease	NNS
cord-000248-zueoyesj	362	14	[	[	-LRB-
cord-000248-zueoyesj	362	15	157	157	CD
cord-000248-zueoyesj	362	16	,	,	,
cord-000248-zueoyesj	362	17	158	158	CD
cord-000248-zueoyesj	362	18	,	,	,
cord-000248-zueoyesj	362	19	159	159	CD
cord-000248-zueoyesj	362	20	,	,	,
cord-000248-zueoyesj	362	21	160	160	CD
cord-000248-zueoyesj	362	22	,	,	,
cord-000248-zueoyesj	362	23	161	161	CD
cord-000248-zueoyesj	362	24	,	,	,
cord-000248-zueoyesj	362	25	162	162	CD
cord-000248-zueoyesj	362	26	,	,	,
cord-000248-zueoyesj	362	27	163	163	CD
cord-000248-zueoyesj	362	28	,	,	,
cord-000248-zueoyesj	362	29	164	164	CD
cord-000248-zueoyesj	362	30	,	,	,
cord-000248-zueoyesj	362	31	165	165	CD
cord-000248-zueoyesj	362	32	,	,	,
cord-000248-zueoyesj	362	33	166	166	CD
cord-000248-zueoyesj	362	34	,	,	,
cord-000248-zueoyesj	362	35	167	167	CD
cord-000248-zueoyesj	362	36	,	,	,
cord-000248-zueoyesj	362	37	168	168	CD
cord-000248-zueoyesj	362	38	,	,	,
cord-000248-zueoyesj	362	39	169	169	CD
cord-000248-zueoyesj	362	40	,	,	,
cord-000248-zueoyesj	362	41	170	170	CD
cord-000248-zueoyesj	362	42	]	]	-RRB-
cord-000248-zueoyesj	363	1	The	the	DT
cord-000248-zueoyesj	363	2	desmosome	desmosome	NN
cord-000248-zueoyesj	363	3	are	be	VBP
cord-000248-zueoyesj	363	4	cell	cell	NN
cord-000248-zueoyesj	363	5	-	-	HYPH
cord-000248-zueoyesj	363	6	cell	cell	NN
cord-000248-zueoyesj	363	7	adhesive	adhesive	NN
cord-000248-zueoyesj	363	8	junctions	junction	NNS
cord-000248-zueoyesj	363	9	which	which	WDT
cord-000248-zueoyesj	363	10	provide	provide	VBP
cord-000248-zueoyesj	363	11	a	a	DT
cord-000248-zueoyesj	363	12	mechanical	mechanical	JJ
cord-000248-zueoyesj	363	13	coupling	coupling	NN
cord-000248-zueoyesj	363	14	between	between	IN
cord-000248-zueoyesj	363	15	cells	cell	NNS
cord-000248-zueoyesj	363	16	.	.	.
cord-000248-zueoyesj	364	1	These	these	DT
cord-000248-zueoyesj	364	2	junctions	junction	NNS
cord-000248-zueoyesj	364	3	are	be	VBP
cord-000248-zueoyesj	364	4	found	find	VBN
cord-000248-zueoyesj	364	5	in	in	IN
cord-000248-zueoyesj	364	6	several	several	JJ
cord-000248-zueoyesj	364	7	epithelial	epithelial	JJ
cord-000248-zueoyesj	364	8	tissues	tissue	NNS
cord-000248-zueoyesj	364	9	and	and	CC
cord-000248-zueoyesj	364	10	the	the	DT
cord-000248-zueoyesj	364	11	decreased	decrease	VBN
cord-000248-zueoyesj	364	12	assembly	assembly	NN
cord-000248-zueoyesj	364	13	of	of	IN
cord-000248-zueoyesj	364	14	the	the	DT
cord-000248-zueoyesj	364	15	desmosome	desmosome	NN
cord-000248-zueoyesj	364	16	has	have	VBZ
cord-000248-zueoyesj	364	17	been	be	VBN
cord-000248-zueoyesj	364	18	shown	show	VBN
cord-000248-zueoyesj	364	19	to	to	TO
cord-000248-zueoyesj	364	20	be	be	VB
cord-000248-zueoyesj	364	21	a	a	DT
cord-000248-zueoyesj	364	22	common	common	JJ
cord-000248-zueoyesj	364	23	feature	feature	NN
cord-000248-zueoyesj	364	24	of	of	IN
cord-000248-zueoyesj	364	25	many	many	JJ
cord-000248-zueoyesj	364	26	epithelial	epithelial	JJ
cord-000248-zueoyesj	364	27	cancers	cancer	NNS
cord-000248-zueoyesj	364	28	[	[	-LRB-
cord-000248-zueoyesj	364	29	171	171	CD
cord-000248-zueoyesj	364	30	,	,	,
cord-000248-zueoyesj	364	31	172	172	CD
cord-000248-zueoyesj	364	32	]	]	-RRB-
cord-000248-zueoyesj	364	33	.	.	.
cord-000248-zueoyesj	365	1	Plakoglobin	Plakoglobin	NNP
cord-000248-zueoyesj	365	2	helps	help	VBZ
cord-000248-zueoyesj	365	3	to	to	TO
cord-000248-zueoyesj	365	4	connect	connect	VB
cord-000248-zueoyesj	365	5	transmembrane	transmembrane	JJ
cord-000248-zueoyesj	365	6	elements	element	NNS
cord-000248-zueoyesj	365	7	to	to	IN
cord-000248-zueoyesj	365	8	the	the	DT
cord-000248-zueoyesj	365	9	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	365	10	[	[	-LRB-
cord-000248-zueoyesj	365	11	173	173	CD
cord-000248-zueoyesj	365	12	]	]	-RRB-
cord-000248-zueoyesj	365	13	.	.	.
cord-000248-zueoyesj	366	1	Plakophilin	plakophilin	JJ
cord-000248-zueoyesj	366	2	1	1	CD
cord-000248-zueoyesj	366	3	[	[	-LRB-
cord-000248-zueoyesj	366	4	174	174	CD
cord-000248-zueoyesj	366	5	]	]	-RRB-
cord-000248-zueoyesj	366	6	(	(	-LRB-
cord-000248-zueoyesj	366	7	PKP1	PKP1	NNP
cord-000248-zueoyesj	366	8	,	,	,
cord-000248-zueoyesj	366	9	one	one	CD
cord-000248-zueoyesj	366	10	of	of	IN
cord-000248-zueoyesj	366	11	the	the	DT
cord-000248-zueoyesj	366	12	genes	gene	NNS
cord-000248-zueoyesj	366	13	in	in	IN
cord-000248-zueoyesj	366	14	our	-PRON-	PRP$
cord-000248-zueoyesj	366	15	panel	panel	NN
cord-000248-zueoyesj	366	16	above	above	RB
cord-000248-zueoyesj	366	17	)	)	-RRB-
cord-000248-zueoyesj	366	18	is	be	VBZ
cord-000248-zueoyesj	366	19	a	a	DT
cord-000248-zueoyesj	366	20	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	366	21	plaque	plaque	NN
cord-000248-zueoyesj	366	22	component	component	NN
cord-000248-zueoyesj	366	23	[	[	-LRB-
cord-000248-zueoyesj	366	24	175	175	CD
cord-000248-zueoyesj	366	25	]	]	-RRB-
cord-000248-zueoyesj	366	26	that	that	WDT
cord-000248-zueoyesj	366	27	stabilizes	stabilize	VBZ
cord-000248-zueoyesj	366	28	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	366	29	proteins	protein	NNS
cord-000248-zueoyesj	366	30	at	at	IN
cord-000248-zueoyesj	366	31	the	the	DT
cord-000248-zueoyesj	366	32	plasma	plasma	NN
cord-000248-zueoyesj	366	33	membrane	membrane	NN
cord-000248-zueoyesj	366	34	[	[	-LRB-
cord-000248-zueoyesj	366	35	176	176	CD
cord-000248-zueoyesj	366	36	,	,	,
cord-000248-zueoyesj	366	37	177	177	CD
cord-000248-zueoyesj	366	38	]	]	-RRB-
cord-000248-zueoyesj	367	1	and	and	CC
cord-000248-zueoyesj	367	2	,	,	,
cord-000248-zueoyesj	367	3	with	with	IN
cord-000248-zueoyesj	367	4	desmoplakin	desmoplakin	NNP
cord-000248-zueoyesj	367	5	[	[	-LRB-
cord-000248-zueoyesj	367	6	178	178	CD
cord-000248-zueoyesj	367	7	]	]	-RRB-
cord-000248-zueoyesj	367	8	,	,	,
cord-000248-zueoyesj	367	9	recruits	recruit	VBZ
cord-000248-zueoyesj	367	10	filaments	filament	NNS
cord-000248-zueoyesj	367	11	to	to	IN
cord-000248-zueoyesj	367	12	sites	site	NNS
cord-000248-zueoyesj	367	13	of	of	IN
cord-000248-zueoyesj	367	14	cell	cell	NN
cord-000248-zueoyesj	367	15	-	-	HYPH
cord-000248-zueoyesj	367	16	cell	cell	NN
cord-000248-zueoyesj	367	17	contacts	contact	NNS
cord-000248-zueoyesj	367	18	[	[	-LRB-
cord-000248-zueoyesj	367	19	179	179	CD
cord-000248-zueoyesj	367	20	]	]	-RRB-
cord-000248-zueoyesj	367	21	.	.	.
cord-000248-zueoyesj	368	1	As	as	IN
cord-000248-zueoyesj	368	2	a	a	DT
cord-000248-zueoyesj	368	3	consequence	consequence	NN
cord-000248-zueoyesj	368	4	,	,	,
cord-000248-zueoyesj	368	5	it	-PRON-	PRP
cord-000248-zueoyesj	368	6	has	have	VBZ
cord-000248-zueoyesj	368	7	been	be	VBN
cord-000248-zueoyesj	368	8	proposed	propose	VBN
cord-000248-zueoyesj	368	9	that	that	IN
cord-000248-zueoyesj	368	10	the	the	DT
cord-000248-zueoyesj	368	11	lack	lack	NN
cord-000248-zueoyesj	368	12	of	of	IN
cord-000248-zueoyesj	368	13	PKP1	PKP1	NNP
cord-000248-zueoyesj	368	14	increases	increase	VBZ
cord-000248-zueoyesj	368	15	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	368	16	migration	migration	NN
cord-000248-zueoyesj	368	17	[	[	-LRB-
cord-000248-zueoyesj	368	18	180	180	CD
cord-000248-zueoyesj	368	19	]	]	-RRB-
cord-000248-zueoyesj	368	20	and	and	CC
cord-000248-zueoyesj	368	21	loss	loss	NN
cord-000248-zueoyesj	368	22	of	of	IN
cord-000248-zueoyesj	368	23	PKP1	pkp1	JJ
cord-000248-zueoyesj	368	24	expression	expression	NN
cord-000248-zueoyesj	368	25	in	in	IN
cord-000248-zueoyesj	368	26	head	head	NN
cord-000248-zueoyesj	368	27	and	and	CC
cord-000248-zueoyesj	368	28	neck	neck	NN
cord-000248-zueoyesj	368	29	squamous	squamous	JJ
cord-000248-zueoyesj	368	30	cell	cell	NN
cord-000248-zueoyesj	368	31	carcinoma	carcinoma	NN
cord-000248-zueoyesj	368	32	and	and	CC
cord-000248-zueoyesj	368	33	in	in	IN
cord-000248-zueoyesj	368	34	esophageal	esophageal	JJ
cord-000248-zueoyesj	368	35	squamous	squamous	JJ
cord-000248-zueoyesj	368	36	cell	cell	NN
cord-000248-zueoyesj	368	37	carcinoma	carcinoma	NN
cord-000248-zueoyesj	368	38	may	may	MD
cord-000248-zueoyesj	368	39	contribute	contribute	VB
cord-000248-zueoyesj	368	40	to	to	IN
cord-000248-zueoyesj	368	41	an	an	DT
cord-000248-zueoyesj	368	42	invasive	invasive	JJ
cord-000248-zueoyesj	368	43	phenotypic	phenotypic	JJ
cord-000248-zueoyesj	368	44	behaviour	behaviour	NN
cord-000248-zueoyesj	368	45	[	[	-LRB-
cord-000248-zueoyesj	368	46	171	171	CD
cord-000248-zueoyesj	368	47	]	]	-RRB-
cord-000248-zueoyesj	368	48	,	,	,
cord-000248-zueoyesj	368	49	perhaps	perhaps	RB
cord-000248-zueoyesj	368	50	as	as	IN
cord-000248-zueoyesj	368	51	a	a	DT
cord-000248-zueoyesj	368	52	consequence	consequence	NN
cord-000248-zueoyesj	368	53	of	of	IN
cord-000248-zueoyesj	368	54	the	the	DT
cord-000248-zueoyesj	368	55	impaired	impaired	JJ
cord-000248-zueoyesj	368	56	recruitment	recruitment	NN
cord-000248-zueoyesj	368	57	of	of	IN
cord-000248-zueoyesj	368	58	desmoplakin	desmoplakin	NNP
cord-000248-zueoyesj	368	59	.	.	.
cord-000248-zueoyesj	369	1	The	the	DT
cord-000248-zueoyesj	369	2	desmoglein	desmoglein	NN
cord-000248-zueoyesj	369	3	-	-	HYPH
cord-000248-zueoyesj	369	4	specific	specific	JJ
cord-000248-zueoyesj	369	5	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	369	6	region	region	NN
cord-000248-zueoyesj	369	7	(	(	-LRB-
cord-000248-zueoyesj	369	8	DSCR	DSCR	NNP
cord-000248-zueoyesj	369	9	)	)	-RRB-
cord-000248-zueoyesj	369	10	is	be	VBZ
cord-000248-zueoyesj	369	11	the	the	DT
cord-000248-zueoyesj	369	12	site	site	NN
cord-000248-zueoyesj	369	13	of	of	IN
cord-000248-zueoyesj	369	14	caspase	caspase	NN
cord-000248-zueoyesj	369	15	cleavage	cleavage	NN
cord-000248-zueoyesj	369	16	during	during	IN
cord-000248-zueoyesj	369	17	apopotosis	apopotosis	NN
cord-000248-zueoyesj	369	18	and	and	CC
cord-000248-zueoyesj	369	19	is	be	VBZ
cord-000248-zueoyesj	369	20	a	a	DT
cord-000248-zueoyesj	369	21	conserved	conserved	JJ
cord-000248-zueoyesj	369	22	region	region	NN
cord-000248-zueoyesj	369	23	of	of	IN
cord-000248-zueoyesj	369	24	yet	yet	RB
cord-000248-zueoyesj	369	25	undefined	undefined	JJ
cord-000248-zueoyesj	369	26	function	function	NN
cord-000248-zueoyesj	369	27	and	and	CC
cord-000248-zueoyesj	369	28	unknown	unknown	JJ
cord-000248-zueoyesj	369	29	structure	structure	NN
cord-000248-zueoyesj	369	30	,	,	,
cord-000248-zueoyesj	369	31	but	but	CC
cord-000248-zueoyesj	369	32	it	-PRON-	PRP
cord-000248-zueoyesj	369	33	specifies	specify	VBZ
cord-000248-zueoyesj	369	34	the	the	DT
cord-000248-zueoyesj	369	35	function	function	NN
cord-000248-zueoyesj	369	36	of	of	IN
cord-000248-zueoyesj	369	37	the	the	DT
cord-000248-zueoyesj	369	38	desmoglein	desmoglein	NNP
cord-000248-zueoyesj	369	39	family	family	NN
cord-000248-zueoyesj	369	40	of	of	IN
cord-000248-zueoyesj	369	41	cell	cell	NN
cord-000248-zueoyesj	369	42	adhesion	adhesion	NN
cord-000248-zueoyesj	369	43	molecules	molecule	NNS
cord-000248-zueoyesj	369	44	(	(	-LRB-
cord-000248-zueoyesj	369	45	of	of	IN
cord-000248-zueoyesj	369	46	which	which	WDT
cord-000248-zueoyesj	369	47	DSG	DSG	NNP
cord-000248-zueoyesj	369	48	1	1	CD
cord-000248-zueoyesj	369	49	is	be	VBZ
cord-000248-zueoyesj	369	50	a	a	DT
cord-000248-zueoyesj	369	51	member	member	NN
cord-000248-zueoyesj	369	52	)	)	-RRB-
cord-000248-zueoyesj	369	53	.	.	.
cord-000248-zueoyesj	370	1	It	-PRON-	PRP
cord-000248-zueoyesj	370	2	has	have	VBZ
cord-000248-zueoyesj	370	3	been	be	VBN
cord-000248-zueoyesj	370	4	recently	recently	RB
cord-000248-zueoyesj	370	5	shown	show	VBN
cord-000248-zueoyesj	370	6	that	that	IN
cord-000248-zueoyesj	370	7	the	the	DT
cord-000248-zueoyesj	370	8	DSCR	DSCR	NNP
cord-000248-zueoyesj	370	9	has	have	VBZ
cord-000248-zueoyesj	370	10	a	a	DT
cord-000248-zueoyesj	370	11	weak	weak	JJ
cord-000248-zueoyesj	370	12	interaction	interaction	NN
cord-000248-zueoyesj	370	13	with	with	IN
cord-000248-zueoyesj	370	14	PKP1	PKP1	NNP
cord-000248-zueoyesj	370	15	,	,	,
cord-000248-zueoyesj	370	16	Plakophilin	Plakophilin	NNP
cord-000248-zueoyesj	370	17	1	1	CD
cord-000248-zueoyesj	370	18	(	(	-LRB-
cord-000248-zueoyesj	370	19	ectodermal	ectodermal	JJ
cord-000248-zueoyesj	370	20	dysplasia	dysplasia	NN
cord-000248-zueoyesj	370	21	/	/	SYM
cord-000248-zueoyesj	370	22	skin	skin	NN
cord-000248-zueoyesj	370	23	fragility	fragility	NN
cord-000248-zueoyesj	370	24	syndrome	syndrome	NN
cord-000248-zueoyesj	370	25	)	)	-RRB-
cord-000248-zueoyesj	370	26	and	and	CC
cord-000248-zueoyesj	370	27	the	the	DT
cord-000248-zueoyesj	370	28	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	370	29	domain	domain	NN
cord-000248-zueoyesj	370	30	of	of	IN
cord-000248-zueoyesj	370	31	Desmocollin	Desmocollin	NNP
cord-000248-zueoyesj	370	32	1	1	CD
cord-000248-zueoyesj	370	33	[	[	-LRB-
cord-000248-zueoyesj	370	34	181	181	CD
cord-000248-zueoyesj	370	35	]	]	-RRB-
cord-000248-zueoyesj	370	36	.	.	.
cord-000248-zueoyesj	371	1	Plakoglobin	Plakoglobin	NNP
cord-000248-zueoyesj	371	2	is	be	VBZ
cord-000248-zueoyesj	371	3	cleaved	cleave	VBN
cord-000248-zueoyesj	371	4	by	by	IN
cord-000248-zueoyesj	371	5	Caspase	Caspase	NNP
cord-000248-zueoyesj	371	6	3	3	CD
cord-000248-zueoyesj	371	7	during	during	IN
cord-000248-zueoyesj	371	8	apoptosis	apoptosis	NN
cord-000248-zueoyesj	371	9	[	[	-LRB-
cord-000248-zueoyesj	371	10	182	182	CD
cord-000248-zueoyesj	371	11	]	]	-RRB-
cord-000248-zueoyesj	371	12	.	.	.
cord-000248-zueoyesj	372	1	In	in	IN
cord-000248-zueoyesj	372	2	addition	addition	NN
cord-000248-zueoyesj	372	3	,	,	,
cord-000248-zueoyesj	372	4	Kami	Kami	NNP
cord-000248-zueoyesj	372	5	et	et	NNP
cord-000248-zueoyesj	372	6	al	al	NNP
cord-000248-zueoyesj	372	7	.	.	.
cord-000248-zueoyesj	373	1	in	in	IN
cord-000248-zueoyesj	373	2	Ref	ref	NN
cord-000248-zueoyesj	373	3	[	[	-LRB-
cord-000248-zueoyesj	373	4	181	181	CD
cord-000248-zueoyesj	373	5	]	]	-RRB-
cord-000248-zueoyesj	373	6	also	also	RB
cord-000248-zueoyesj	373	7	report	report	VBP
cord-000248-zueoyesj	373	8	and	and	CC
cord-000248-zueoyesj	373	9	conclude	conclude	VBP
cord-000248-zueoyesj	373	10	that	that	DT
cord-000248-zueoyesj	373	11	:	:	:
cord-000248-zueoyesj	373	12	'	'	''
cord-000248-zueoyesj	373	13	'	'	''
cord-000248-zueoyesj	373	14	desmoglein	desmoglein	NNP
cord-000248-zueoyesj	373	15	1	1	CD
cord-000248-zueoyesj	373	16	membrane	membrane	NN
cord-000248-zueoyesj	373	17	proximal	proximal	JJ
cord-000248-zueoyesj	373	18	region	region	NN
cord-000248-zueoyesj	373	19	also	also	RB
cord-000248-zueoyesj	373	20	interacts	interact	VBZ
cord-000248-zueoyesj	373	21	with	with	IN
cord-000248-zueoyesj	373	22	all	all	DT
cord-000248-zueoyesj	373	23	four	four	CD
cord-000248-zueoyesj	373	24	DSCR	DSCR	NNP
cord-000248-zueoyesj	373	25	ligands	ligand	NNS
cord-000248-zueoyesj	373	26	,	,	,
cord-000248-zueoyesj	373	27	strongly	strongly	RB
cord-000248-zueoyesj	373	28	with	with	IN
cord-000248-zueoyesj	373	29	plakoglobin	plakoglobin	NNP
cord-000248-zueoyesj	373	30	and	and	CC
cord-000248-zueoyesj	373	31	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	373	32	and	and	CC
cord-000248-zueoyesj	373	33	more	more	RBR
cord-000248-zueoyesj	373	34	weakly	weakly	RB
cord-000248-zueoyesj	373	35	with	with	IN
cord-000248-zueoyesj	373	36	desmoplakin	desmoplakin	NNP
cord-000248-zueoyesj	373	37	and	and	CC
cord-000248-zueoyesj	373	38	desmocollin	desmocollin	NNP
cord-000248-zueoyesj	373	39	1	1	CD
cord-000248-zueoyesj	373	40	.	.	.
cord-000248-zueoyesj	374	1	Thus	thus	RB
cord-000248-zueoyesj	374	2	,	,	,
cord-000248-zueoyesj	374	3	the	the	DT
cord-000248-zueoyesj	374	4	DSCR	DSCR	NNP
cord-000248-zueoyesj	374	5	is	be	VBZ
cord-000248-zueoyesj	374	6	an	an	DT
cord-000248-zueoyesj	374	7	intrinsically	intrinsically	RB
cord-000248-zueoyesj	374	8	disordered	disordered	JJ
cord-000248-zueoyesj	374	9	functional	functional	JJ
cord-000248-zueoyesj	374	10	domain	domain	NN
cord-000248-zueoyesj	374	11	with	with	IN
cord-000248-zueoyesj	374	12	an	an	DT
cord-000248-zueoyesj	374	13	inducible	inducible	JJ
cord-000248-zueoyesj	374	14	structure	structure	NN
cord-000248-zueoyesj	374	15	that	that	IN
cord-000248-zueoyesj	374	16	,	,	,
cord-000248-zueoyesj	374	17	along	along	IN
cord-000248-zueoyesj	374	18	with	with	IN
cord-000248-zueoyesj	374	19	the	the	DT
cord-000248-zueoyesj	374	20	membrane	membrane	NN
cord-000248-zueoyesj	374	21	proximal	proximal	JJ
cord-000248-zueoyesj	374	22	region	region	NN
cord-000248-zueoyesj	374	23	,	,	,
cord-000248-zueoyesj	374	24	forms	form	VBZ
cord-000248-zueoyesj	374	25	a	a	DT
cord-000248-zueoyesj	374	26	flexible	flexible	JJ
cord-000248-zueoyesj	374	27	scaffold	scaffold	NN
cord-000248-zueoyesj	374	28	for	for	IN
cord-000248-zueoyesj	374	29	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	374	30	assembly	assembly	NN
cord-000248-zueoyesj	374	31	at	at	IN
cord-000248-zueoyesj	374	32	the	the	DT
cord-000248-zueoyesj	374	33	desmosome	desmosome	NN
cord-000248-zueoyesj	374	34	'	'	''
cord-000248-zueoyesj	374	35	'	'	''
cord-000248-zueoyesj	374	36	.	.	.
cord-000248-zueoyesj	375	1	As	as	IN
cord-000248-zueoyesj	375	2	previously	previously	RB
cord-000248-zueoyesj	375	3	discussed	discuss	VBN
cord-000248-zueoyesj	375	4	,	,	,
cord-000248-zueoyesj	375	5	all	all	PDT
cord-000248-zueoyesj	375	6	these	these	DT
cord-000248-zueoyesj	375	7	genes	gene	NNS
cord-000248-zueoyesj	375	8	progress	progress	VBP
cord-000248-zueoyesj	375	9	towards	towards	IN
cord-000248-zueoyesj	375	10	a	a	DT
cord-000248-zueoyesj	375	11	loss	loss	NN
cord-000248-zueoyesj	375	12	of	of	IN
cord-000248-zueoyesj	375	13	expression	expression	NN
cord-000248-zueoyesj	375	14	,	,	,
cord-000248-zueoyesj	375	15	and	and	CC
cord-000248-zueoyesj	375	16	they	-PRON-	PRP
cord-000248-zueoyesj	375	17	are	be	VBP
cord-000248-zueoyesj	375	18	highly	highly	RB
cord-000248-zueoyesj	375	19	correlated	correlate	VBN
cord-000248-zueoyesj	375	20	.	.	.
cord-000248-zueoyesj	376	1	Figure	figure	NN
cord-000248-zueoyesj	376	2	9	9	CD
cord-000248-zueoyesj	376	3	shows	show	VBZ
cord-000248-zueoyesj	376	4	the	the	DT
cord-000248-zueoyesj	376	5	average	average	JJ
cord-000248-zueoyesj	376	6	expression	expression	NN
cord-000248-zueoyesj	376	7	of	of	IN
cord-000248-zueoyesj	376	8	PKP1	PKP1	NNP
cord-000248-zueoyesj	376	9	/	/	SYM
cord-000248-zueoyesj	376	10	Plakophilin	Plakophilin	NNP
cord-000248-zueoyesj	376	11	1	1	CD
cord-000248-zueoyesj	376	12	(	(	-LRB-
cord-000248-zueoyesj	376	13	ectodermal	ectodermal	NNS
cord-000248-zueoyesj	376	14	dysplasia/	dysplasia/	CD
cord-000248-zueoyesj	376	15	skin	skin	NN
cord-000248-zueoyesj	376	16	fragility	fragility	NN
cord-000248-zueoyesj	376	17	syndrome	syndrome	NN
cord-000248-zueoyesj	376	18	)	)	-RRB-
cord-000248-zueoyesj	376	19	,	,	,
cord-000248-zueoyesj	376	20	(	(	-LRB-
cord-000248-zueoyesj	376	21	NM_000299	NM_000299	NNP
cord-000248-zueoyesj	376	22	)	)	-RRB-
cord-000248-zueoyesj	376	23	and	and	CC
cord-000248-zueoyesj	376	24	JUP	JUP	NNP
cord-000248-zueoyesj	376	25	,	,	,
cord-000248-zueoyesj	376	26	Junction	Junction	NNP
cord-000248-zueoyesj	376	27	plakoglobin	plakoglobin	NNP
cord-000248-zueoyesj	376	28	,	,	,
cord-000248-zueoyesj	376	29	(	(	-LRB-
cord-000248-zueoyesj	376	30	BX648177	bx648177	NN
cord-000248-zueoyesj	376	31	)	)	-RRB-
cord-000248-zueoyesj	376	32	on	on	IN
cord-000248-zueoyesj	376	33	the	the	DT
cord-000248-zueoyesj	376	34	x	x	NN
cord-000248-zueoyesj	376	35	-	-	HYPH
cord-000248-zueoyesj	376	36	axis	axis	NN
cord-000248-zueoyesj	376	37	against	against	IN
cord-000248-zueoyesj	376	38	that	that	DT
cord-000248-zueoyesj	376	39	of	of	IN
cord-000248-zueoyesj	376	40	DSP	DSP	NNP
cord-000248-zueoyesj	376	41	,	,	,
cord-000248-zueoyesj	376	42	Desmoplakin	Desmoplakin	NNP
cord-000248-zueoyesj	376	43	(	(	-LRB-
cord-000248-zueoyesj	376	44	NM_004415	NM_004415	NNP
cord-000248-zueoyesj	376	45	Hs.519873	hs.519873	NN
cord-000248-zueoyesj	376	46	)	)	-RRB-
cord-000248-zueoyesj	376	47	on	on	IN
cord-000248-zueoyesj	376	48	the	the	DT
cord-000248-zueoyesj	376	49	y	y	NN
cord-000248-zueoyesj	376	50	-	-	HYPH
cord-000248-zueoyesj	376	51	axis	axis	NN
cord-000248-zueoyesj	376	52	.	.	.
cord-000248-zueoyesj	377	1	Again	again	RB
cord-000248-zueoyesj	377	2	,	,	,
cord-000248-zueoyesj	377	3	we	-PRON-	PRP
cord-000248-zueoyesj	377	4	see	see	VBP
cord-000248-zueoyesj	377	5	a	a	DT
cord-000248-zueoyesj	377	6	clear	clear	JJ
cord-000248-zueoyesj	377	7	pattern	pattern	NN
cord-000248-zueoyesj	377	8	of	of	IN
cord-000248-zueoyesj	377	9	progressive	progressive	JJ
cord-000248-zueoyesj	377	10	reduction	reduction	NN
cord-000248-zueoyesj	377	11	of	of	IN
cord-000248-zueoyesj	377	12	expression	expression	NN
cord-000248-zueoyesj	377	13	from	from	IN
cord-000248-zueoyesj	377	14	normal	normal	JJ
cord-000248-zueoyesj	377	15	skin	skin	NN
cord-000248-zueoyesj	377	16	and	and	CC
cord-000248-zueoyesj	377	17	nevi	nevus	NNS
cord-000248-zueoyesj	377	18	(	(	-LRB-
cord-000248-zueoyesj	377	19	green	green	JJ
cord-000248-zueoyesj	377	20	and	and	CC
cord-000248-zueoyesj	377	21	yellow	yellow	JJ
cord-000248-zueoyesj	377	22	,	,	,
cord-000248-zueoyesj	377	23	respectively	respectively	RB
cord-000248-zueoyesj	377	24	)	)	-RRB-
cord-000248-zueoyesj	377	25	,	,	,
cord-000248-zueoyesj	377	26	primary	primary	JJ
cord-000248-zueoyesj	377	27	melanomas	melanoma	NNS
cord-000248-zueoyesj	377	28	(	(	-LRB-
cord-000248-zueoyesj	377	29	in	in	IN
cord-000248-zueoyesj	377	30	orange	orange	NN
cord-000248-zueoyesj	377	31	)	)	-RRB-
cord-000248-zueoyesj	377	32	and	and	CC
cord-000248-zueoyesj	377	33	melanoma	melanoma	NN
cord-000248-zueoyesj	377	34	metastases	metastasis	NNS
cord-000248-zueoyesj	377	35	(	(	-LRB-
cord-000248-zueoyesj	377	36	red	red	JJ
cord-000248-zueoyesj	377	37	)	)	-RRB-
cord-000248-zueoyesj	377	38	.	.	.
cord-000248-zueoyesj	378	1	Joint	joint	JJ
cord-000248-zueoyesj	378	2	loss	loss	NN
cord-000248-zueoyesj	378	3	of	of	IN
cord-000248-zueoyesj	378	4	expression	expression	NN
cord-000248-zueoyesj	378	5	of	of	IN
cord-000248-zueoyesj	378	6	Claudin	Claudin	NNP
cord-000248-zueoyesj	378	7	1	1	CD
cord-000248-zueoyesj	378	8	and	and	CC
cord-000248-zueoyesj	378	9	members	member	NNS
cord-000248-zueoyesj	378	10	of	of	IN
cord-000248-zueoyesj	378	11	the	the	DT
cord-000248-zueoyesj	378	12	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	378	13	family	family	NN
cord-000248-zueoyesj	378	14	are	be	VBP
cord-000248-zueoyesj	378	15	also	also	RB
cord-000248-zueoyesj	378	16	linked	link	VBN
cord-000248-zueoyesj	378	17	to	to	IN
cord-000248-zueoyesj	378	18	a	a	DT
cord-000248-zueoyesj	378	19	transition	transition	NN
cord-000248-zueoyesj	378	20	to	to	IN
cord-000248-zueoyesj	378	21	a	a	DT
cord-000248-zueoyesj	378	22	more	more	RBR
cord-000248-zueoyesj	378	23	malignant	malignant	JJ
cord-000248-zueoyesj	378	24	phenotype	phenotype	NN
cord-000248-zueoyesj	378	25	We	-PRON-	PRP
cord-000248-zueoyesj	378	26	note	note	VBP
cord-000248-zueoyesj	378	27	however	however	RB
cord-000248-zueoyesj	378	28	,	,	,
cord-000248-zueoyesj	378	29	the	the	DT
cord-000248-zueoyesj	378	30	Gene	Gene	NNP
cord-000248-zueoyesj	378	31	Ontology	Ontology	NNP
cord-000248-zueoyesj	378	32	annotation	annotation	NN
cord-000248-zueoyesj	378	33	is	be	VBZ
cord-000248-zueoyesj	378	34	not	not	RB
cord-000248-zueoyesj	378	35	the	the	DT
cord-000248-zueoyesj	378	36	only	only	JJ
cord-000248-zueoyesj	378	37	way	way	NN
cord-000248-zueoyesj	378	38	that	that	WDT
cord-000248-zueoyesj	378	39	we	-PRON-	PRP
cord-000248-zueoyesj	378	40	can	can	MD
cord-000248-zueoyesj	378	41	make	make	VB
cord-000248-zueoyesj	378	42	sense	sense	NN
cord-000248-zueoyesj	378	43	of	of	IN
cord-000248-zueoyesj	378	44	this	this	DT
cord-000248-zueoyesj	378	45	information	information	NN
cord-000248-zueoyesj	378	46	.	.	.
cord-000248-zueoyesj	379	1	A	a	DT
cord-000248-zueoyesj	379	2	detailed	detailed	JJ
cord-000248-zueoyesj	379	3	analysis	analysis	NN
cord-000248-zueoyesj	379	4	of	of	IN
cord-000248-zueoyesj	379	5	that	that	DT
cord-000248-zueoyesj	379	6	list	list	NN
cord-000248-zueoyesj	379	7	of	of	IN
cord-000248-zueoyesj	379	8	58	58	CD
cord-000248-zueoyesj	379	9	genes	gene	NNS
cord-000248-zueoyesj	379	10	reveals	reveal	VBZ
cord-000248-zueoyesj	379	11	other	other	JJ
cord-000248-zueoyesj	379	12	proteins	protein	NNS
cord-000248-zueoyesj	379	13	involved	involve	VBN
cord-000248-zueoyesj	379	14	in	in	IN
cord-000248-zueoyesj	379	15	tight	tight	JJ
cord-000248-zueoyesj	379	16	junction	junction	NN
cord-000248-zueoyesj	379	17	,	,	,
cord-000248-zueoyesj	379	18	like	like	IN
cord-000248-zueoyesj	379	19	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	379	20	3	3	CD
cord-000248-zueoyesj	379	21	(	(	-LRB-
cord-000248-zueoyesj	379	22	AQP3	AQP3	NNP
cord-000248-zueoyesj	379	23	)	)	-RRB-
cord-000248-zueoyesj	379	24	.	.	.
cord-000248-zueoyesj	380	1	Probes	probe	NNS
cord-000248-zueoyesj	380	2	for	for	IN
cord-000248-zueoyesj	380	3	AQP3	AQP3	NNP
cord-000248-zueoyesj	380	4	and	and	CC
cord-000248-zueoyesj	380	5	Claudin	Claudin	NNP
cord-000248-zueoyesj	380	6	1	1	CD
cord-000248-zueoyesj	380	7	(	(	-LRB-
cord-000248-zueoyesj	380	8	CLDN1	CLDN1	NNP
cord-000248-zueoyesj	380	9	)	)	-RRB-
cord-000248-zueoyesj	380	10	have	have	VBP
cord-000248-zueoyesj	380	11	reduced	reduce	VBN
cord-000248-zueoyesj	380	12	expression	expression	NN
cord-000248-zueoyesj	380	13	with	with	IN
cord-000248-zueoyesj	380	14	the	the	DT
cord-000248-zueoyesj	380	15	progression	progression	NN
cord-000248-zueoyesj	380	16	of	of	IN
cord-000248-zueoyesj	380	17	the	the	DT
cord-000248-zueoyesj	380	18	disease	disease	NN
cord-000248-zueoyesj	380	19	as	as	IN
cord-000248-zueoyesj	380	20	shown	show	VBN
cord-000248-zueoyesj	380	21	in	in	IN
cord-000248-zueoyesj	380	22	Figure	Figure	NNP
cord-000248-zueoyesj	380	23	10	10	CD
cord-000248-zueoyesj	380	24	.	.	.
cord-000248-zueoyesj	381	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	382	1	(	(	-LRB-
cord-000248-zueoyesj	382	2	Gill	Gill	NNP
cord-000248-zueoyesj	382	3	blood	blood	NN
cord-000248-zueoyesj	382	4	group	group	NN
cord-000248-zueoyesj	382	5	)	)	-RRB-
cord-000248-zueoyesj	382	6	is	be	VBZ
cord-000248-zueoyesj	382	7	a	a	DT
cord-000248-zueoyesj	382	8	member	member	NN
cord-000248-zueoyesj	382	9	of	of	IN
cord-000248-zueoyesj	382	10	the	the	DT
cord-000248-zueoyesj	382	11	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	382	12	family	family	NN
cord-000248-zueoyesj	382	13	of	of	IN
cord-000248-zueoyesj	382	14	proteins	protein	NNS
cord-000248-zueoyesj	382	15	,	,	,
cord-000248-zueoyesj	382	16	and	and	CC
cord-000248-zueoyesj	382	17	currently	currently	RB
cord-000248-zueoyesj	382	18	is	be	VBZ
cord-000248-zueoyesj	382	19	recognized	recognize	VBN
cord-000248-zueoyesj	382	20	as	as	IN
cord-000248-zueoyesj	382	21	an	an	DT
cord-000248-zueoyesj	382	22	'	'	``
cord-000248-zueoyesj	382	23	aquaglyceroporin	aquaglyceroporin	FW
cord-000248-zueoyesj	382	24	'	'	''
cord-000248-zueoyesj	382	25	[	[	-LRB-
cord-000248-zueoyesj	382	26	183	183	CD
cord-000248-zueoyesj	382	27	]	]	-RRB-
cord-000248-zueoyesj	382	28	of	of	IN
cord-000248-zueoyesj	382	29	great	great	JJ
cord-000248-zueoyesj	382	30	importance	importance	NN
cord-000248-zueoyesj	382	31	to	to	TO
cord-000248-zueoyesj	382	32	maintain	maintain	VB
cord-000248-zueoyesj	382	33	skin	skin	NN
cord-000248-zueoyesj	382	34	hydration	hydration	NN
cord-000248-zueoyesj	382	35	of	of	IN
cord-000248-zueoyesj	382	36	mammals	mammal	NNS
cord-000248-zueoyesj	382	37	epidermis	epidermi	NNS
cord-000248-zueoyesj	382	38	[	[	-LRB-
cord-000248-zueoyesj	382	39	184	184	CD
cord-000248-zueoyesj	382	40	]	]	-RRB-
cord-000248-zueoyesj	382	41	.	.	.
cord-000248-zueoyesj	383	1	Three	three	CD
cord-000248-zueoyesj	383	2	proteins	protein	NNS
cord-000248-zueoyesj	383	3	of	of	IN
cord-000248-zueoyesj	383	4	this	this	DT
cord-000248-zueoyesj	383	5	family	family	NN
cord-000248-zueoyesj	383	6	(	(	-LRB-
cord-000248-zueoyesj	383	7	AQP1	AQP1	NNP
cord-000248-zueoyesj	383	8	,	,	,
cord-000248-zueoyesj	383	9	AQP3	AQP3	NNP
cord-000248-zueoyesj	383	10	,	,	,
cord-000248-zueoyesj	383	11	and	and	CC
cord-000248-zueoyesj	383	12	AQP9	AQP9	NNP
cord-000248-zueoyesj	383	13	)	)	-RRB-
cord-000248-zueoyesj	383	14	have	have	VBP
cord-000248-zueoyesj	383	15	probes	probe	NNS
cord-000248-zueoyesj	383	16	that	that	WDT
cord-000248-zueoyesj	383	17	seem	seem	VBP
cord-000248-zueoyesj	383	18	correlated	correlate	VBN
cord-000248-zueoyesj	383	19	with	with	IN
cord-000248-zueoyesj	383	20	melanoma	melanoma	NN
cord-000248-zueoyesj	383	21	progression	progression	NN
cord-000248-zueoyesj	383	22	,	,	,
cord-000248-zueoyesj	383	23	all	all	DT
cord-000248-zueoyesj	383	24	losing	lose	VBG
cord-000248-zueoyesj	383	25	their	-PRON-	PRP$
cord-000248-zueoyesj	383	26	expression	expression	NN
cord-000248-zueoyesj	383	27	in	in	IN
cord-000248-zueoyesj	383	28	the	the	DT
cord-000248-zueoyesj	383	29	process	process	NN
cord-000248-zueoyesj	383	30	of	of	IN
cord-000248-zueoyesj	383	31	going	go	VBG
cord-000248-zueoyesj	383	32	from	from	IN
cord-000248-zueoyesj	383	33	normal	normal	JJ
cord-000248-zueoyesj	383	34	skin	skin	NN
cord-000248-zueoyesj	383	35	to	to	IN
cord-000248-zueoyesj	383	36	metastatic	metastatic	JJ
cord-000248-zueoyesj	383	37	melanoma	melanoma	NN
cord-000248-zueoyesj	383	38	.	.	.
cord-000248-zueoyesj	384	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	384	2	water	water	NN
cord-000248-zueoyesj	384	3	channels	channel	NNS
cord-000248-zueoyesj	384	4	have	have	VBP
cord-000248-zueoyesj	384	5	been	be	VBN
cord-000248-zueoyesj	384	6	pointed	point	VBN
cord-000248-zueoyesj	384	7	out	out	RP
cord-000248-zueoyesj	384	8	as	as	IN
cord-000248-zueoyesj	384	9	an	an	DT
cord-000248-zueoyesj	384	10	essential	essential	JJ
cord-000248-zueoyesj	384	11	pathway	pathway	NN
cord-000248-zueoyesj	384	12	for	for	IN
cord-000248-zueoyesj	384	13	volume	volume	NN
cord-000248-zueoyesj	384	14	-	-	HYPH
cord-000248-zueoyesj	384	15	regulatory	regulatory	JJ
cord-000248-zueoyesj	384	16	water	water	NN
cord-000248-zueoyesj	384	17	transport	transport	NN
cord-000248-zueoyesj	384	18	in	in	IN
cord-000248-zueoyesj	384	19	human	human	JJ
cord-000248-zueoyesj	384	20	epithelial	epithelial	JJ
cord-000248-zueoyesj	384	21	cells	cell	NNS
cord-000248-zueoyesj	384	22	[	[	-LRB-
cord-000248-zueoyesj	384	23	185	185	CD
cord-000248-zueoyesj	384	24	]	]	-RRB-
cord-000248-zueoyesj	384	25	.	.	.
cord-000248-zueoyesj	385	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	385	2	is	be	VBZ
cord-000248-zueoyesj	385	3	also	also	RB
cord-000248-zueoyesj	385	4	selective	selective	JJ
cord-000248-zueoyesj	385	5	for	for	IN
cord-000248-zueoyesj	385	6	the	the	DT
cord-000248-zueoyesj	385	7	passage	passage	NN
cord-000248-zueoyesj	385	8	of	of	IN
cord-000248-zueoyesj	385	9	glycerol	glycerol	NN
cord-000248-zueoyesj	385	10	and	and	CC
cord-000248-zueoyesj	385	11	urea	urea	NN
cord-000248-zueoyesj	385	12	and	and	CC
cord-000248-zueoyesj	385	13	it	-PRON-	PRP
cord-000248-zueoyesj	385	14	has	have	VBZ
cord-000248-zueoyesj	385	15	been	be	VBN
cord-000248-zueoyesj	385	16	suggested	suggest	VBN
cord-000248-zueoyesj	385	17	that	that	IN
cord-000248-zueoyesj	385	18	osmotic	osmotic	JJ
cord-000248-zueoyesj	385	19	stress	stress	NN
cord-000248-zueoyesj	385	20	up	up	RB
cord-000248-zueoyesj	385	21	-	-	HYPH
cord-000248-zueoyesj	385	22	regulates	regulate	VBZ
cord-000248-zueoyesj	385	23	AQP3	AQP3	NNP
cord-000248-zueoyesj	385	24	gene	gene	NN
cord-000248-zueoyesj	385	25	expression	expression	NN
cord-000248-zueoyesj	385	26	in	in	IN
cord-000248-zueoyesj	385	27	cultured	cultured	JJ
cord-000248-zueoyesj	385	28	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	385	29	[	[	-LRB-
cord-000248-zueoyesj	385	30	186	186	CD
cord-000248-zueoyesj	385	31	]	]	-RRB-
cord-000248-zueoyesj	385	32	.	.	.
cord-000248-zueoyesj	386	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	386	2	was	be	VBD
cord-000248-zueoyesj	386	3	found	find	VBN
cord-000248-zueoyesj	386	4	to	to	TO
cord-000248-zueoyesj	386	5	be	be	VB
cord-000248-zueoyesj	386	6	the	the	DT
cord-000248-zueoyesj	386	7	predominant	predominant	JJ
cord-000248-zueoyesj	386	8	aquaporin	aquaporin	NN
cord-000248-zueoyesj	386	9	in	in	IN
cord-000248-zueoyesj	386	10	human	human	JJ
cord-000248-zueoyesj	386	11	skin	skin	NN
cord-000248-zueoyesj	386	12	which	which	WDT
cord-000248-zueoyesj	386	13	increased	increase	VBD
cord-000248-zueoyesj	386	14	expression	expression	NN
cord-000248-zueoyesj	386	15	and	and	CC
cord-000248-zueoyesj	386	16	altered	alter	VBN
cord-000248-zueoyesj	386	17	cellular	cellular	JJ
cord-000248-zueoyesj	386	18	distribution	distribution	NN
cord-000248-zueoyesj	386	19	of	of	IN
cord-000248-zueoyesj	386	20	AQP3	AQP3	NNP
cord-000248-zueoyesj	386	21	in	in	IN
cord-000248-zueoyesj	386	22	eczema	eczema	NN
cord-000248-zueoyesj	386	23	thus	thus	RB
cord-000248-zueoyesj	386	24	contributing	contribute	VBG
cord-000248-zueoyesj	386	25	to	to	IN
cord-000248-zueoyesj	386	26	water	water	NN
cord-000248-zueoyesj	386	27	loss	loss	NN
cord-000248-zueoyesj	386	28	[	[	-LRB-
cord-000248-zueoyesj	386	29	187	187	CD
cord-000248-zueoyesj	386	30	]	]	-RRB-
cord-000248-zueoyesj	386	31	.	.	.
cord-000248-zueoyesj	387	1	The	the	DT
cord-000248-zueoyesj	387	2	putative	putative	JJ
cord-000248-zueoyesj	387	3	involvement	involvement	NN
cord-000248-zueoyesj	387	4	of	of	IN
cord-000248-zueoyesj	387	5	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	387	6	in	in	IN
cord-000248-zueoyesj	387	7	the	the	DT
cord-000248-zueoyesj	387	8	progression	progression	NN
cord-000248-zueoyesj	387	9	of	of	IN
cord-000248-zueoyesj	387	10	melanoma	melanoma	NN
cord-000248-zueoyesj	387	11	,	,	,
cord-000248-zueoyesj	387	12	uncovered	uncover	VBN
cord-000248-zueoyesj	387	13	by	by	IN
cord-000248-zueoyesj	387	14	our	-PRON-	PRP$
cord-000248-zueoyesj	387	15	method	method	NN
cord-000248-zueoyesj	387	16	in	in	IN
cord-000248-zueoyesj	387	17	our	-PRON-	PRP$
cord-000248-zueoyesj	387	18	results	result	NNS
cord-000248-zueoyesj	387	19	,	,	,
cord-000248-zueoyesj	387	20	warrants	warrant	NNS
cord-000248-zueoyesj	387	21	further	further	JJ
cord-000248-zueoyesj	387	22	investigation	investigation	NN
cord-000248-zueoyesj	387	23	as	as	IN
cord-000248-zueoyesj	387	24	it	-PRON-	PRP
cord-000248-zueoyesj	387	25	has	have	VBZ
cord-000248-zueoyesj	387	26	been	be	VBN
cord-000248-zueoyesj	387	27	recently	recently	RB
cord-000248-zueoyesj	387	28	shown	show	VBN
cord-000248-zueoyesj	387	29	that	that	IN
cord-000248-zueoyesj	387	30	another	another	DT
cord-000248-zueoyesj	387	31	member	member	NN
cord-000248-zueoyesj	387	32	of	of	IN
cord-000248-zueoyesj	387	33	this	this	DT
cord-000248-zueoyesj	387	34	family	family	NN
cord-000248-zueoyesj	387	35	(	(	-LRB-
cord-000248-zueoyesj	387	36	AQP8	AQP8	NNP
cord-000248-zueoyesj	387	37	)	)	-RRB-
cord-000248-zueoyesj	387	38	also	also	RB
cord-000248-zueoyesj	387	39	facilitates	facilitate	VBZ
cord-000248-zueoyesj	387	40	hydrogen	hydrogen	NN
cord-000248-zueoyesj	387	41	peroxide	peroxide	NN
cord-000248-zueoyesj	387	42	diffusion	diffusion	NN
cord-000248-zueoyesj	387	43	across	across	IN
cord-000248-zueoyesj	387	44	membranes	membrane	NNS
cord-000248-zueoyesj	387	45	[	[	-LRB-
cord-000248-zueoyesj	387	46	188	188	CD
cord-000248-zueoyesj	387	47	]	]	-RRB-
cord-000248-zueoyesj	387	48	.	.	.
cord-000248-zueoyesj	388	1	It	-PRON-	PRP
cord-000248-zueoyesj	388	2	is	be	VBZ
cord-000248-zueoyesj	388	3	suspected	suspect	VBN
cord-000248-zueoyesj	388	4	that	that	IN
cord-000248-zueoyesj	388	5	AQP3	AQP3	NNP
cord-000248-zueoyesj	388	6	has	have	VBZ
cord-000248-zueoyesj	388	7	other	other	JJ
cord-000248-zueoyesj	388	8	functions	function	NNS
cord-000248-zueoyesj	388	9	with	with	IN
cord-000248-zueoyesj	388	10	a	a	DT
cord-000248-zueoyesj	388	11	suggestion	suggestion	NN
cord-000248-zueoyesj	388	12	that	that	IN
cord-000248-zueoyesj	388	13	it	-PRON-	PRP
cord-000248-zueoyesj	388	14	is	be	VBZ
cord-000248-zueoyesj	388	15	involved	involve	VBN
cord-000248-zueoyesj	388	16	in	in	IN
cord-000248-zueoyesj	388	17	ultraviolet	ultraviolet	JJ
cord-000248-zueoyesj	388	18	radiation	radiation	NN
cord-000248-zueoyesj	388	19	induced	induce	VBD
cord-000248-zueoyesj	388	20	skin	skin	NN
cord-000248-zueoyesj	388	21	dehydration	dehydration	NN
cord-000248-zueoyesj	388	22	[	[	-LRB-
cord-000248-zueoyesj	388	23	189	189	CD
cord-000248-zueoyesj	388	24	]	]	-RRB-
cord-000248-zueoyesj	388	25	.	.	.
cord-000248-zueoyesj	389	1	There	there	EX
cord-000248-zueoyesj	389	2	is	be	VBZ
cord-000248-zueoyesj	389	3	no	no	DT
cord-000248-zueoyesj	389	4	probe	probe	NN
cord-000248-zueoyesj	389	5	for	for	IN
cord-000248-zueoyesj	389	6	AQP8	AQP8	NNP
cord-000248-zueoyesj	389	7	in	in	IN
cord-000248-zueoyesj	389	8	Haqq	Haqq	NNP
cord-000248-zueoyesj	389	9	et	et	NNP
cord-000248-zueoyesj	389	10	al	al	NNP
cord-000248-zueoyesj	389	11	.	.	NNP
cord-000248-zueoyesj	389	12	's	's	POS
cord-000248-zueoyesj	389	13	dataset	dataset	NN
cord-000248-zueoyesj	389	14	that	that	IN
cord-000248-zueoyesj	389	15	we	-PRON-	PRP
cord-000248-zueoyesj	389	16	could	could	MD
cord-000248-zueoyesj	389	17	scrutinize	scrutinize	VB
cord-000248-zueoyesj	389	18	from	from	IN
cord-000248-zueoyesj	389	19	its	-PRON-	PRP$
cord-000248-zueoyesj	389	20	trend	trend	NN
cord-000248-zueoyesj	389	21	with	with	IN
cord-000248-zueoyesj	389	22	progression	progression	NN
cord-000248-zueoyesj	389	23	but	but	CC
cord-000248-zueoyesj	389	24	we	-PRON-	PRP
cord-000248-zueoyesj	389	25	note	note	VBP
cord-000248-zueoyesj	389	26	that	that	IN
cord-000248-zueoyesj	389	27	a	a	DT
cord-000248-zueoyesj	389	28	novel	novel	JJ
cord-000248-zueoyesj	389	29	strategy	strategy	NN
cord-000248-zueoyesj	389	30	for	for	IN
cord-000248-zueoyesj	389	31	drug	drug	NN
cord-000248-zueoyesj	389	32	development	development	NN
cord-000248-zueoyesj	389	33	for	for	IN
cord-000248-zueoyesj	389	34	melanoma	melanoma	NN
cord-000248-zueoyesj	389	35	(	(	-LRB-
cord-000248-zueoyesj	389	36	i.e.	i.e.	FW
cord-000248-zueoyesj	389	37	Elesclomol	Elesclomol	NNP
cord-000248-zueoyesj	389	38	)	)	-RRB-
cord-000248-zueoyesj	389	39	works	work	VBZ
cord-000248-zueoyesj	389	40	by	by	IN
cord-000248-zueoyesj	389	41	inducing	induce	VBG
cord-000248-zueoyesj	389	42	apoptosis	apoptosis	NN
cord-000248-zueoyesj	389	43	via	via	IN
cord-000248-zueoyesj	389	44	a	a	DT
cord-000248-zueoyesj	389	45	mechanism	mechanism	NN
cord-000248-zueoyesj	389	46	of	of	IN
cord-000248-zueoyesj	389	47	elevation	elevation	NN
cord-000248-zueoyesj	389	48	of	of	IN
cord-000248-zueoyesj	389	49	reactive	reactive	JJ
cord-000248-zueoyesj	389	50	oxygen	oxygen	NN
cord-000248-zueoyesj	389	51	species	specie	NNS
cord-000248-zueoyesj	389	52	(	(	-LRB-
cord-000248-zueoyesj	389	53	of	of	IN
cord-000248-zueoyesj	389	54	course	course	NN
cord-000248-zueoyesj	389	55	,	,	,
cord-000248-zueoyesj	389	56	including	include	VBG
cord-000248-zueoyesj	389	57	hydrogen	hydrogen	NN
cord-000248-zueoyesj	389	58	peroxide	peroxide	NN
cord-000248-zueoyesj	389	59	in	in	IN
cord-000248-zueoyesj	389	60	cancer	cancer	NN
cord-000248-zueoyesj	389	61	cells	cell	NNS
cord-000248-zueoyesj	389	62	)	)	-RRB-
cord-000248-zueoyesj	389	63	thus	thus	RB
cord-000248-zueoyesj	389	64	exploiting	exploit	VBG
cord-000248-zueoyesj	389	65	the	the	DT
cord-000248-zueoyesj	389	66	'	'	``
cord-000248-zueoyesj	389	67	'	'	``
cord-000248-zueoyesj	389	68	Achilles	Achilles	NNP
cord-000248-zueoyesj	389	69	hell	hell	NN
cord-000248-zueoyesj	389	70	of	of	IN
cord-000248-zueoyesj	389	71	cancer	cancer	NN
cord-000248-zueoyesj	389	72	metabolism	metabolism	NN
cord-000248-zueoyesj	389	73	'	'	''
cord-000248-zueoyesj	389	74	'	'	''
cord-000248-zueoyesj	389	75	[	[	-LRB-
cord-000248-zueoyesj	389	76	190	190	CD
cord-000248-zueoyesj	389	77	]	]	-RRB-
cord-000248-zueoyesj	389	78	.	.	.
cord-000248-zueoyesj	390	1	Claudin	Claudin	NNP
cord-000248-zueoyesj	390	2	1	1	CD
cord-000248-zueoyesj	390	3	,	,	,
cord-000248-zueoyesj	390	4	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	390	5	[	[	-LRB-
cord-000248-zueoyesj	390	6	191	191	CD
cord-000248-zueoyesj	390	7	]	]	-RRB-
cord-000248-zueoyesj	390	8	,	,	,
cord-000248-zueoyesj	390	9	a	a	DT
cord-000248-zueoyesj	390	10	gene	gene	NN
cord-000248-zueoyesj	390	11	which	which	WDT
cord-000248-zueoyesj	390	12	is	be	VBZ
cord-000248-zueoyesj	390	13	reported	report	VBN
cord-000248-zueoyesj	390	14	to	to	TO
cord-000248-zueoyesj	390	15	be	be	VB
cord-000248-zueoyesj	390	16	'	'	''
cord-000248-zueoyesj	390	17	'	'	''
cord-000248-zueoyesj	390	18	normally	normally	RB
cord-000248-zueoyesj	390	19	expressed	express	VBN
cord-000248-zueoyesj	390	20	in	in	IN
cord-000248-zueoyesj	390	21	all	all	PDT
cord-000248-zueoyesj	390	22	the	the	DT
cord-000248-zueoyesj	390	23	living	living	NN
cord-000248-zueoyesj	390	24	layers	layer	NNS
cord-000248-zueoyesj	390	25	of	of	IN
cord-000248-zueoyesj	390	26	the	the	DT
cord-000248-zueoyesj	390	27	epidermis	epidermis	NN
cord-000248-zueoyesj	390	28	'	'	''
cord-000248-zueoyesj	390	29	'	'	''
cord-000248-zueoyesj	390	30	[	[	-LRB-
cord-000248-zueoyesj	390	31	192	192	CD
cord-000248-zueoyesj	390	32	]	]	-RRB-
cord-000248-zueoyesj	390	33	,	,	,
cord-000248-zueoyesj	390	34	in	in	IN
cord-000248-zueoyesj	390	35	concert	concert	NN
cord-000248-zueoyesj	390	36	with	with	IN
cord-000248-zueoyesj	390	37	AQP3	AQP3	NNP
cord-000248-zueoyesj	390	38	,	,	,
cord-000248-zueoyesj	390	39	is	be	VBZ
cord-000248-zueoyesj	390	40	a	a	DT
cord-000248-zueoyesj	390	41	key	key	JJ
cord-000248-zueoyesj	390	42	component	component	NN
cord-000248-zueoyesj	390	43	of	of	IN
cord-000248-zueoyesj	390	44	the	the	DT
cord-000248-zueoyesj	390	45	tight	tight	JJ
cord-000248-zueoyesj	390	46	junction	junction	NN
cord-000248-zueoyesj	390	47	complexes	complex	NNS
cord-000248-zueoyesj	390	48	of	of	IN
cord-000248-zueoyesj	390	49	the	the	DT
cord-000248-zueoyesj	390	50	epidermis	epidermis	NN
cord-000248-zueoyesj	390	51	.	.	.
cord-000248-zueoyesj	391	1	Low	low	JJ
cord-000248-zueoyesj	391	2	CLDN1	cldn1	NN
cord-000248-zueoyesj	391	3	gene	gene	NN
cord-000248-zueoyesj	391	4	expression	expression	NN
cord-000248-zueoyesj	391	5	was	be	VBD
cord-000248-zueoyesj	391	6	correlated	correlate	VBN
cord-000248-zueoyesj	391	7	with	with	IN
cord-000248-zueoyesj	391	8	shorter	short	JJR
cord-000248-zueoyesj	391	9	overall	overall	JJ
cord-000248-zueoyesj	391	10	survival	survival	NN
cord-000248-zueoyesj	391	11	in	in	IN
cord-000248-zueoyesj	391	12	lung	lung	NN
cord-000248-zueoyesj	391	13	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	391	14	.	.	.
cord-000248-zueoyesj	392	1	Overexpression	overexpression	NN
cord-000248-zueoyesj	392	2	of	of	IN
cord-000248-zueoyesj	392	3	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	392	4	was	be	VBD
cord-000248-zueoyesj	392	5	correlated	correlate	VBN
cord-000248-zueoyesj	392	6	with	with	IN
cord-000248-zueoyesj	392	7	suppression	suppression	NN
cord-000248-zueoyesj	392	8	of	of	IN
cord-000248-zueoyesj	392	9	cancer	cancer	NN
cord-000248-zueoyesj	392	10	cell	cell	NN
cord-000248-zueoyesj	392	11	migration	migration	NN
cord-000248-zueoyesj	392	12	,	,	,
cord-000248-zueoyesj	392	13	invasion	invasion	NN
cord-000248-zueoyesj	392	14	and	and	CC
cord-000248-zueoyesj	392	15	metastasis	metastasis	NN
cord-000248-zueoyesj	392	16	[	[	-LRB-
cord-000248-zueoyesj	392	17	193	193	CD
cord-000248-zueoyesj	392	18	]	]	-RRB-
cord-000248-zueoyesj	392	19	.	.	.
cord-000248-zueoyesj	393	1	Hoevel	Hoevel	NNP
cord-000248-zueoyesj	393	2	et	et	NNP
cord-000248-zueoyesj	393	3	al	al	NNP
cord-000248-zueoyesj	393	4	.	.	.
cord-000248-zueoyesj	394	1	report	report	VB
cord-000248-zueoyesj	394	2	that	that	IN
cord-000248-zueoyesj	394	3	re	re	NN
cord-000248-zueoyesj	394	4	-	-	NN
cord-000248-zueoyesj	394	5	expression	expression	NN
cord-000248-zueoyesj	394	6	of	of	IN
cord-000248-zueoyesj	394	7	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	394	8	,	,	,
cord-000248-zueoyesj	394	9	in	in	IN
cord-000248-zueoyesj	394	10	breast	breast	NN
cord-000248-zueoyesj	394	11	tumor	tumor	NN
cord-000248-zueoyesj	394	12	spheroids	spheroid	NNS
cord-000248-zueoyesj	394	13	,	,	,
cord-000248-zueoyesj	394	14	induces	induce	VBZ
cord-000248-zueoyesj	394	15	apoptosis	apoptosis	NN
cord-000248-zueoyesj	394	16	and	and	CC
cord-000248-zueoyesj	394	17	they	-PRON-	PRP
cord-000248-zueoyesj	394	18	conclude	conclude	VBP
cord-000248-zueoyesj	394	19	:	:	:
cord-000248-zueoyesj	394	20	''	''	''
cord-000248-zueoyesj	395	1	These	these	DT
cord-000248-zueoyesj	395	2	findings	finding	NNS
cord-000248-zueoyesj	395	3	support	support	VBP
cord-000248-zueoyesj	395	4	a	a	DT
cord-000248-zueoyesj	395	5	potential	potential	JJ
cord-000248-zueoyesj	395	6	role	role	NN
cord-000248-zueoyesj	395	7	of	of	IN
cord-000248-zueoyesj	395	8	the	the	DT
cord-000248-zueoyesj	395	9	tight	tight	JJ
cord-000248-zueoyesj	395	10	junction	junction	NN
cord-000248-zueoyesj	395	11	protein	protein	NN
cord-000248-zueoyesj	395	12	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	395	13	in	in	IN
cord-000248-zueoyesj	395	14	restricting	restrict	VBG
cord-000248-zueoyesj	395	15	nutrient	nutrient	NN
cord-000248-zueoyesj	395	16	and	and	CC
cord-000248-zueoyesj	395	17	growth	growth	NN
cord-000248-zueoyesj	395	18	factor	factor	NN
cord-000248-zueoyesj	395	19	supplies	supply	NNS
cord-000248-zueoyesj	395	20	in	in	IN
cord-000248-zueoyesj	395	21	breast	breast	NN
cord-000248-zueoyesj	395	22	cancer	cancer	NN
cord-000248-zueoyesj	395	23	cells	cell	NNS
cord-000248-zueoyesj	395	24	,	,	,
cord-000248-zueoyesj	395	25	and	and	CC
cord-000248-zueoyesj	395	26	they	-PRON-	PRP
cord-000248-zueoyesj	395	27	indicate	indicate	VBP
cord-000248-zueoyesj	395	28	that	that	IN
cord-000248-zueoyesj	395	29	the	the	DT
cord-000248-zueoyesj	395	30	loss	loss	NN
cord-000248-zueoyesj	395	31	of	of	IN
cord-000248-zueoyesj	395	32	the	the	DT
cord-000248-zueoyesj	395	33	cell	cell	NN
cord-000248-zueoyesj	395	34	membrane	membrane	NN
cord-000248-zueoyesj	395	35	localization	localization	NN
cord-000248-zueoyesj	395	36	of	of	IN
cord-000248-zueoyesj	395	37	the	the	DT
cord-000248-zueoyesj	395	38	tight	tight	JJ
cord-000248-zueoyesj	395	39	junction	junction	NN
cord-000248-zueoyesj	395	40	protein	protein	NN
cord-000248-zueoyesj	395	41	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	395	42	in	in	IN
cord-000248-zueoyesj	395	43	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	395	44	may	may	MD
cord-000248-zueoyesj	395	45	be	be	VB
cord-000248-zueoyesj	395	46	a	a	DT
cord-000248-zueoyesj	395	47	crucial	crucial	JJ
cord-000248-zueoyesj	395	48	step	step	NN
cord-000248-zueoyesj	395	49	during	during	IN
cord-000248-zueoyesj	395	50	tumor	tumor	NN
cord-000248-zueoyesj	395	51	progression	progression	NN
cord-000248-zueoyesj	395	52	'	'	''
cord-000248-zueoyesj	395	53	'	'	''
cord-000248-zueoyesj	395	54	[	[	-LRB-
cord-000248-zueoyesj	395	55	194	194	CD
cord-000248-zueoyesj	395	56	]	]	-RRB-
cord-000248-zueoyesj	395	57	.	.	.
cord-000248-zueoyesj	396	1	Tokes	Tokes	NNP
cord-000248-zueoyesj	396	2	et	et	NNP
cord-000248-zueoyesj	396	3	al.also	al.also	NNP
cord-000248-zueoyesj	396	4	report	report	VBP
cord-000248-zueoyesj	396	5	that	that	IN
cord-000248-zueoyesj	396	6	malignant	malignant	JJ
cord-000248-zueoyesj	396	7	invasive	invasive	JJ
cord-000248-zueoyesj	396	8	breast	breast	NN
cord-000248-zueoyesj	396	9	tumors	tumor	NNS
cord-000248-zueoyesj	396	10	are	be	VBP
cord-000248-zueoyesj	396	11	negative	negative	JJ
cord-000248-zueoyesj	396	12	Table	table	NN
cord-000248-zueoyesj	396	13	1	1	CD
cord-000248-zueoyesj	396	14	.	.	.
cord-000248-zueoyesj	397	1	Gene	gene	NN
cord-000248-zueoyesj	397	2	names	name	NNS
cord-000248-zueoyesj	397	3	and	and	CC
cord-000248-zueoyesj	397	4	probe	probe	VBP
cord-000248-zueoyesj	397	5	accession	accession	NN
cord-000248-zueoyesj	397	6	number	number	NN
cord-000248-zueoyesj	397	7	of	of	IN
cord-000248-zueoyesj	397	8	the	the	DT
cord-000248-zueoyesj	397	9	27	27	CD
cord-000248-zueoyesj	397	10	probes	probe	NNS
cord-000248-zueoyesj	397	11	with	with	IN
cord-000248-zueoyesj	397	12	genes	gene	NNS
cord-000248-zueoyesj	397	13	annotated	annotate	VBN
cord-000248-zueoyesj	397	14	with	with	IN
cord-000248-zueoyesj	397	15	functions	function	NNS
cord-000248-zueoyesj	397	16	on	on	IN
cord-000248-zueoyesj	397	17	cell	cell	NN
cord-000248-zueoyesj	397	18	adhesion	adhesion	NN
cord-000248-zueoyesj	397	19	,	,	,
cord-000248-zueoyesj	397	20	cell	cell	NN
cord-000248-zueoyesj	397	21	-	-	HYPH
cord-000248-zueoyesj	397	22	cell	cell	NN
cord-000248-zueoyesj	397	23	communication	communication	NN
cord-000248-zueoyesj	397	24	,	,	,
cord-000248-zueoyesj	397	25	tight	tight	JJ
cord-000248-zueoyesj	397	26	junction	junction	NN
cord-000248-zueoyesj	397	27	mechanisms	mechanism	NNS
cord-000248-zueoyesj	397	28	and	and	CC
cord-000248-zueoyesj	397	29	epithelial	epithelial	JJ
cord-000248-zueoyesj	397	30	cell	cell	NN
cord-000248-zueoyesj	397	31	polarity	polarity	NN
cord-000248-zueoyesj	397	32	shown	show	VBN
cord-000248-zueoyesj	397	33	in	in	IN
cord-000248-zueoyesj	397	34	the	the	DT
cord-000248-zueoyesj	397	35	heat	heat	NN
cord-000248-zueoyesj	397	36	map	map	NN
cord-000248-zueoyesj	397	37	in	in	IN
cord-000248-zueoyesj	397	38	Figure	Figure	NNP
cord-000248-zueoyesj	397	39	8	8	CD
cord-000248-zueoyesj	397	40	.	.	.
cord-000248-zueoyesj	398	1	for	for	IN
cord-000248-zueoyesj	398	2	CLDN1	CLDN1	NNP
cord-000248-zueoyesj	398	3	[	[	-LRB-
cord-000248-zueoyesj	398	4	195	195	CD
cord-000248-zueoyesj	398	5	]	]	-RRB-
cord-000248-zueoyesj	398	6	.	.	.
cord-000248-zueoyesj	399	1	As	as	IN
cord-000248-zueoyesj	399	2	in	in	IN
cord-000248-zueoyesj	399	3	breast	breast	NN
cord-000248-zueoyesj	399	4	cancer	cancer	NN
cord-000248-zueoyesj	399	5	[	[	-LRB-
cord-000248-zueoyesj	399	6	196	196	CD
cord-000248-zueoyesj	399	7	]	]	-RRB-
cord-000248-zueoyesj	399	8	,	,	,
cord-000248-zueoyesj	399	9	in	in	IN
cord-000248-zueoyesj	399	10	which	which	WDT
cord-000248-zueoyesj	399	11	reduced	reduced	JJ
cord-000248-zueoyesj	399	12	expression	expression	NN
cord-000248-zueoyesj	399	13	correlated	correlate	VBN
cord-000248-zueoyesj	399	14	with	with	IN
cord-000248-zueoyesj	399	15	recurrence	recurrence	NN
cord-000248-zueoyesj	399	16	status	status	NN
cord-000248-zueoyesj	399	17	,	,	,
cord-000248-zueoyesj	399	18	the	the	DT
cord-000248-zueoyesj	399	19	low	low	JJ
cord-000248-zueoyesj	399	20	expression	expression	NN
cord-000248-zueoyesj	399	21	of	of	IN
cord-000248-zueoyesj	399	22	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	399	23	and	and	CC
cord-000248-zueoyesj	399	24	other	other	JJ
cord-000248-zueoyesj	399	25	tight	tight	JJ
cord-000248-zueoyesj	399	26	junction	junction	NN
cord-000248-zueoyesj	399	27	proteins	protein	NNS
cord-000248-zueoyesj	399	28	seems	seem	VBZ
cord-000248-zueoyesj	399	29	to	to	TO
cord-000248-zueoyesj	399	30	contribute	contribute	VB
cord-000248-zueoyesj	399	31	to	to	IN
cord-000248-zueoyesj	399	32	cellular	cellular	JJ
cord-000248-zueoyesj	399	33	detachment	detachment	NN
cord-000248-zueoyesj	399	34	.	.	.
cord-000248-zueoyesj	400	1	The	the	DT
cord-000248-zueoyesj	400	2	complementary	complementary	JJ
cord-000248-zueoyesj	400	3	set	set	NN
cord-000248-zueoyesj	400	4	of	of	IN
cord-000248-zueoyesj	400	5	correlations	correlation	NNS
cord-000248-zueoyesj	400	6	with	with	IN
cord-000248-zueoyesj	400	7	the	the	DT
cord-000248-zueoyesj	400	8	Jensen	Jensen	NNP
cord-000248-zueoyesj	400	9	-	-	HYPH
cord-000248-zueoyesj	400	10	Shannon	Shannon	NNP
cord-000248-zueoyesj	400	11	divergences	divergence	NNS
cord-000248-zueoyesj	400	12	unveils	unveil	VBZ
cord-000248-zueoyesj	400	13	biomarkers	biomarker	NNS
cord-000248-zueoyesj	400	14	for	for	IN
cord-000248-zueoyesj	400	15	cell	cell	NN
cord-000248-zueoyesj	400	16	proliferation	proliferation	NN
cord-000248-zueoyesj	400	17	,	,	,
cord-000248-zueoyesj	400	18	chemotaxis	chemotaxis	NN
cord-000248-zueoyesj	400	19	,	,	,
cord-000248-zueoyesj	400	20	and	and	CC
cord-000248-zueoyesj	400	21	responses	response	NNS
cord-000248-zueoyesj	400	22	to	to	IN
cord-000248-zueoyesj	400	23	external	external	JJ
cord-000248-zueoyesj	400	24	simulus	simulus	NN
cord-000248-zueoyesj	400	25	.	.	.
cord-000248-zueoyesj	401	1	If	if	IN
cord-000248-zueoyesj	401	2	the	the	DT
cord-000248-zueoyesj	401	3	use	use	NN
cord-000248-zueoyesj	401	4	of	of	IN
cord-000248-zueoyesj	401	5	Gene	Gene	NNP
cord-000248-zueoyesj	401	6	Ontology	Ontology	NNP
cord-000248-zueoyesj	401	7	has	have	VBZ
cord-000248-zueoyesj	401	8	produced	produce	VBN
cord-000248-zueoyesj	401	9	very	very	RB
cord-000248-zueoyesj	401	10	peculiar	peculiar	JJ
cord-000248-zueoyesj	401	11	results	result	NNS
cord-000248-zueoyesj	401	12	,	,	,
cord-000248-zueoyesj	401	13	helping	help	VBG
cord-000248-zueoyesj	401	14	us	-PRON-	PRP
cord-000248-zueoyesj	401	15	to	to	TO
cord-000248-zueoyesj	401	16	link	link	VB
cord-000248-zueoyesj	401	17	the	the	DT
cord-000248-zueoyesj	401	18	loss	loss	NN
cord-000248-zueoyesj	401	19	of	of	IN
cord-000248-zueoyesj	401	20	expression	expression	NN
cord-000248-zueoyesj	401	21	of	of	IN
cord-000248-zueoyesj	401	22	44	44	CD
cord-000248-zueoyesj	401	23	genes	gene	NNS
cord-000248-zueoyesj	401	24	with	with	IN
cord-000248-zueoyesj	401	25	a	a	DT
cord-000248-zueoyesj	401	26	significant	significant	JJ
cord-000248-zueoyesj	401	27	change	change	NN
cord-000248-zueoyesj	401	28	in	in	IN
cord-000248-zueoyesj	401	29	epithelial	epithelial	JJ
cord-000248-zueoyesj	401	30	structure	structure	NN
cord-000248-zueoyesj	401	31	and	and	CC
cord-000248-zueoyesj	401	32	development	development	NN
cord-000248-zueoyesj	401	33	.	.	.
cord-000248-zueoyesj	402	1	A	a	DT
cord-000248-zueoyesj	402	2	natural	natural	JJ
cord-000248-zueoyesj	402	3	question	question	NN
cord-000248-zueoyesj	402	4	arises	arise	VBZ
cord-000248-zueoyesj	402	5	:	:	:
cord-000248-zueoyesj	402	6	'	'	''
cord-000248-zueoyesj	402	7	'	'	''
cord-000248-zueoyesj	402	8	Which	which	WDT
cord-000248-zueoyesj	402	9	is	be	VBZ
cord-000248-zueoyesj	402	10	the	the	DT
cord-000248-zueoyesj	402	11	significance	significance	NN
cord-000248-zueoyesj	402	12	of	of	IN
cord-000248-zueoyesj	402	13	another	another	DT
cord-000248-zueoyesj	402	14	set	set	NN
cord-000248-zueoyesj	402	15	,	,	,
cord-000248-zueoyesj	402	16	now	now	RB
cord-000248-zueoyesj	402	17	arbitrarily	arbitrarily	RB
cord-000248-zueoyesj	402	18	chosen	choose	VBN
cord-000248-zueoyesj	402	19	to	to	TO
cord-000248-zueoyesj	402	20	be	be	VB
cord-000248-zueoyesj	402	21	also	also	RB
cord-000248-zueoyesj	402	22	of	of	IN
cord-000248-zueoyesj	402	23	the	the	DT
cord-000248-zueoyesj	402	24	same	same	JJ
cord-000248-zueoyesj	402	25	cardinality	cardinality	NN
cord-000248-zueoyesj	402	26	(	(	-LRB-
cord-000248-zueoyesj	402	27	i.e	i.e	NNP
cord-000248-zueoyesj	402	28	44	44	CD
cord-000248-zueoyesj	402	29	genes	gene	NNS
cord-000248-zueoyesj	402	30	)	)	-RRB-
cord-000248-zueoyesj	402	31	with	with	IN
cord-000248-zueoyesj	402	32	the	the	DT
cord-000248-zueoyesj	402	33	complementary	complementary	JJ
cord-000248-zueoyesj	402	34	behavioural	behavioural	JJ
cord-000248-zueoyesj	402	35	pattern	pattern	NN
cord-000248-zueoyesj	402	36	?	?	.
cord-000248-zueoyesj	402	37	'	'	''
cord-000248-zueoyesj	402	38	'	'	''
cord-000248-zueoyesj	402	39	We	-PRON-	PRP
cord-000248-zueoyesj	402	40	have	have	VBP
cord-000248-zueoyesj	402	41	now	now	RB
cord-000248-zueoyesj	402	42	listed	list	VBN
cord-000248-zueoyesj	402	43	all	all	PDT
cord-000248-zueoyesj	402	44	the	the	DT
cord-000248-zueoyesj	402	45	probes	probe	NNS
cord-000248-zueoyesj	402	46	according	accord	VBG
cord-000248-zueoyesj	402	47	to	to	IN
cord-000248-zueoyesj	402	48	Diff	Diff	NNP
cord-000248-zueoyesj	402	49	.	.	.
cord-000248-zueoyesj	403	1	(	(	-LRB-
cord-000248-zueoyesj	403	2	probe	probe	NN
cord-000248-zueoyesj	403	3	)	)	-RRB-
cord-000248-zueoyesj	404	1	=	=	SYM
cord-000248-zueoyesj	404	2	JSM0(probe)2JSM5(probe	JSM0(probe)2JSM5(probe	NNP
cord-000248-zueoyesj	404	3	)	)	-RRB-
cord-000248-zueoyesj	404	4	in	in	IN
cord-000248-zueoyesj	404	5	decreasing	decrease	VBG
cord-000248-zueoyesj	404	6	order	order	NN
cord-000248-zueoyesj	404	7	.	.	.
cord-000248-zueoyesj	405	1	The	the	DT
cord-000248-zueoyesj	405	2	results	result	NNS
cord-000248-zueoyesj	405	3	are	be	VBP
cord-000248-zueoyesj	405	4	provided	provide	VBN
cord-000248-zueoyesj	405	5	as	as	IN
cord-000248-zueoyesj	405	6	Haqq-PLoSONE-SupFile.xls	Haqq-PLoSONE-SupFile.xls	NNP
cord-000248-zueoyesj	405	7	(	(	-LRB-
cord-000248-zueoyesj	405	8	'	'	``
cord-000248-zueoyesj	405	9	Results	result	NNS
cord-000248-zueoyesj	405	10	-	-	HYPH
cord-000248-zueoyesj	405	11	correlation	correlation	NN
cord-000248-zueoyesj	405	12	'	'	''
cord-000248-zueoyesj	405	13	sheet	sheet	NN
cord-000248-zueoyesj	405	14	)	)	-RRB-
cord-000248-zueoyesj	405	15	.	.	.
cord-000248-zueoyesj	406	1	This	this	DT
cord-000248-zueoyesj	406	2	now	now	RB
cord-000248-zueoyesj	406	3	gives	give	VBZ
cord-000248-zueoyesj	406	4	ADA	ADA	NNP
cord-000248-zueoyesj	406	5	as	as	IN
cord-000248-zueoyesj	406	6	the	the	DT
cord-000248-zueoyesj	406	7	first	first	JJ
cord-000248-zueoyesj	406	8	ranked	ranked	JJ
cord-000248-zueoyesj	406	9	gene	gene	NN
cord-000248-zueoyesj	406	10	.	.	.
cord-000248-zueoyesj	407	1	Again	again	RB
cord-000248-zueoyesj	407	2	using	use	VBG
cord-000248-zueoyesj	407	3	GATHER	gather	VB
cord-000248-zueoyesj	407	4	[	[	-LRB-
cord-000248-zueoyesj	407	5	155	155	CD
cord-000248-zueoyesj	407	6	]	]	-RRB-
cord-000248-zueoyesj	407	7	on	on	IN
cord-000248-zueoyesj	407	8	the	the	DT
cord-000248-zueoyesj	407	9	first	first	JJ
cord-000248-zueoyesj	407	10	44	44	CD
cord-000248-zueoyesj	407	11	genes	gene	NNS
cord-000248-zueoyesj	407	12	recognized	recognize	VBN
cord-000248-zueoyesj	407	13	by	by	IN
cord-000248-zueoyesj	407	14	the	the	DT
cord-000248-zueoyesj	407	15	software	software	NN
cord-000248-zueoyesj	407	16	,	,	,
cord-000248-zueoyesj	407	17	and	and	CC
cord-000248-zueoyesj	407	18	again	again	RB
cord-000248-zueoyesj	407	19	using	use	VBG
cord-000248-zueoyesj	407	20	Gene	Gene	NNP
cord-000248-zueoyesj	407	21	Ontology	Ontology	NNP
cord-000248-zueoyesj	407	22	,	,	,
cord-000248-zueoyesj	407	23	we	-PRON-	PRP
cord-000248-zueoyesj	407	24	observe	observe	VBP
cord-000248-zueoyesj	407	25	as	as	IN
cord-000248-zueoyesj	407	26	most	most	RBS
cord-000248-zueoyesj	407	27	important	important	JJ
cord-000248-zueoyesj	407	28	common	common	JJ
cord-000248-zueoyesj	407	29	function	function	NN
cord-000248-zueoyesj	407	30	that	that	WDT
cord-000248-zueoyesj	407	31	of	of	IN
cord-000248-zueoyesj	407	32	cell	cell	NN
cord-000248-zueoyesj	407	33	motility	motility	NN
cord-000248-zueoyesj	407	34	(	(	-LRB-
cord-000248-zueoyesj	407	35	CCL3	CCL3	NNP
cord-000248-zueoyesj	407	36	,	,	,
cord-000248-zueoyesj	407	37	CXCL10	CXCL10	NNP
cord-000248-zueoyesj	407	38	,	,	,
cord-000248-zueoyesj	407	39	FPRL1	FPRL1	NNP
cord-000248-zueoyesj	407	40	,	,	,
cord-000248-zueoyesj	407	41	SEMA6A	SEMA6A	NNP
cord-000248-zueoyesj	407	42	,	,	,
cord-000248-zueoyesj	407	43	SPP1	SPP1	NNP
cord-000248-zueoyesj	407	44	)	)	-RRB-
cord-000248-zueoyesj	407	45	,	,	,
cord-000248-zueoyesj	407	46	p	p	NN
cord-000248-zueoyesj	407	47	-	-	HYPH
cord-000248-zueoyesj	407	48	value	value	NN
cord-000248-zueoyesj	407	49	=	=	SYM
cord-000248-zueoyesj	407	50	0.0002	0.0002	CD
cord-000248-zueoyesj	407	51	,	,	,
cord-000248-zueoyesj	407	52	Bayes	Bayes	NNP
cord-000248-zueoyesj	407	53	Factor	Factor	NNP
cord-000248-zueoyesj	407	54	5	5	CD
cord-000248-zueoyesj	407	55	,	,	,
cord-000248-zueoyesj	407	56	and	and	CC
cord-000248-zueoyesj	407	57	chemotaxis	chemotaxis	NN
cord-000248-zueoyesj	407	58	(	(	-LRB-
cord-000248-zueoyesj	407	59	CCL3	CCL3	NNP
cord-000248-zueoyesj	407	60	,	,	,
cord-000248-zueoyesj	407	61	CKLFSF7	cklfsf7	NN
cord-000248-zueoyesj	407	62	,	,	,
cord-000248-zueoyesj	407	63	CXCL10	CXCL10	NNP
cord-000248-zueoyesj	407	64	,	,	,
cord-000248-zueoyesj	407	65	FPRL1	FPRL1	NNS
cord-000248-zueoyesj	407	66	,	,	,
cord-000248-zueoyesj	407	67	SPP1	SPP1	NNP
cord-000248-zueoyesj	407	68	)	)	-RRB-
cord-000248-zueoyesj	407	69	,	,	,
cord-000248-zueoyesj	407	70	p	p	NN
cord-000248-zueoyesj	407	71	-	-	HYPH
cord-000248-zueoyesj	407	72	value,0.0001	value,0.0001	NNP
cord-000248-zueoyesj	407	73	,	,	,
cord-000248-zueoyesj	407	74	Bayes	Bayes	NNP
cord-000248-zueoyesj	407	75	Factor	Factor	NNP
cord-000248-zueoyesj	407	76	7	7	CD
cord-000248-zueoyesj	407	77	.	.	.
cord-000248-zueoyesj	408	1	The	the	DT
cord-000248-zueoyesj	408	2	genes	gene	NNS
cord-000248-zueoyesj	408	3	CXCL10	CXCL10	NNP
cord-000248-zueoyesj	408	4	,	,	,
cord-000248-zueoyesj	408	5	SPP1	SPP1	NNPS
cord-000248-zueoyesj	408	6	,	,	,
cord-000248-zueoyesj	408	7	and	and	CC
cord-000248-zueoyesj	408	8	WARS	war	NNS
cord-000248-zueoyesj	408	9	,	,	,
cord-000248-zueoyesj	408	10	together	together	RB
cord-000248-zueoyesj	408	11	with	with	IN
cord-000248-zueoyesj	408	12	another	another	DT
cord-000248-zueoyesj	408	13	gene	gene	NN
cord-000248-zueoyesj	408	14	that	that	WDT
cord-000248-zueoyesj	408	15	has	have	VBZ
cord-000248-zueoyesj	408	16	been	be	VBN
cord-000248-zueoyesj	408	17	annotated	annotate	VBN
cord-000248-zueoyesj	408	18	as	as	IN
cord-000248-zueoyesj	408	19	related	relate	VBN
cord-000248-zueoyesj	408	20	to	to	IN
cord-000248-zueoyesj	408	21	positive	positive	JJ
cord-000248-zueoyesj	408	22	regulation	regulation	NN
cord-000248-zueoyesj	408	23	of	of	IN
cord-000248-zueoyesj	408	24	mitosis	mitosis	NN
cord-000248-zueoyesj	408	25	(	(	-LRB-
cord-000248-zueoyesj	408	26	SCH1	SCH1	NNP
cord-000248-zueoyesj	408	27	)	)	-RRB-
cord-000248-zueoyesj	408	28	,	,	,
cord-000248-zueoyesj	408	29	have	have	VBP
cord-000248-zueoyesj	408	30	also	also	RB
cord-000248-zueoyesj	408	31	been	be	VBN
cord-000248-zueoyesj	408	32	annotated	annotate	VBN
cord-000248-zueoyesj	408	33	as	as	IN
cord-000248-zueoyesj	408	34	regulators	regulator	NNS
cord-000248-zueoyesj	408	35	of	of	IN
cord-000248-zueoyesj	408	36	cell	cell	NN
cord-000248-zueoyesj	408	37	proliferation	proliferation	NN
cord-000248-zueoyesj	408	38	(	(	-LRB-
cord-000248-zueoyesj	408	39	pvalue	pvalue	NNP
cord-000248-zueoyesj	408	40	=	=	SYM
cord-000248-zueoyesj	408	41	0.007	0.007	CD
cord-000248-zueoyesj	408	42	,	,	,
cord-000248-zueoyesj	408	43	Bayes	Bayes	NNP
cord-000248-zueoyesj	408	44	Factor	Factor	NNP
cord-000248-zueoyesj	408	45	2	2	CD
cord-000248-zueoyesj	408	46	)	)	-RRB-
cord-000248-zueoyesj	408	47	.	.	.
cord-000248-zueoyesj	409	1	Using	use	VBG
cord-000248-zueoyesj	409	2	the	the	DT
cord-000248-zueoyesj	409	3	g	g	NN
cord-000248-zueoyesj	409	4	:	:	:
cord-000248-zueoyesj	409	5	Profiler	profiler	NN
cord-000248-zueoyesj	409	6	software	software	NN
cord-000248-zueoyesj	409	7	[	[	-LRB-
cord-000248-zueoyesj	409	8	156	156	CD
cord-000248-zueoyesj	409	9	]	]	-RRB-
cord-000248-zueoyesj	409	10	,	,	,
cord-000248-zueoyesj	409	11	we	-PRON-	PRP
cord-000248-zueoyesj	409	12	obtain	obtain	VBP
cord-000248-zueoyesj	409	13	a	a	DT
cord-000248-zueoyesj	409	14	complementary	complementary	JJ
cord-000248-zueoyesj	409	15	information	information	NN
cord-000248-zueoyesj	409	16	.	.	.
cord-000248-zueoyesj	410	1	Sixteen	sixteen	CD
cord-000248-zueoyesj	410	2	genes	gene	NNS
cord-000248-zueoyesj	410	3	(	(	-LRB-
cord-000248-zueoyesj	410	4	including	include	VBG
cord-000248-zueoyesj	410	5	SPP1	SPP1	NNP
cord-000248-zueoyesj	410	6	,	,	,
cord-000248-zueoyesj	410	7	SEMA6A	SEMA6A	NNP
cord-000248-zueoyesj	410	8	,	,	,
cord-000248-zueoyesj	410	9	LEF1	LEF1	NNP
cord-000248-zueoyesj	410	10	[	[	-LRB-
cord-000248-zueoyesj	410	11	197	197	CD
cord-000248-zueoyesj	410	12	]	]	-RRB-
cord-000248-zueoyesj	410	13	,	,	,
cord-000248-zueoyesj	410	14	CD230	cd230	NN
cord-000248-zueoyesj	410	15	,	,	,
cord-000248-zueoyesj	410	16	ALS2CR2	als2cr2	CD
cord-000248-zueoyesj	410	17	,	,	,
cord-000248-zueoyesj	410	18	DKK1	DKK1	NNP
cord-000248-zueoyesj	410	19	,	,	,
cord-000248-zueoyesj	410	20	CYFIP2	CYFIP2	NNS
cord-000248-zueoyesj	410	21	,	,	,
cord-000248-zueoyesj	410	22	SHC1	SHC1	NNP
cord-000248-zueoyesj	410	23	,	,	,
cord-000248-zueoyesj	410	24	ANKRD7	ANKRD7	NNP
cord-000248-zueoyesj	410	25	,	,	,
cord-000248-zueoyesj	410	26	IFI6	IFI6	NNP
cord-000248-zueoyesj	410	27	,	,	,
cord-000248-zueoyesj	410	28	CITED1	cited1	NN
cord-000248-zueoyesj	410	29	,	,	,
cord-000248-zueoyesj	410	30	and	and	CC
cord-000248-zueoyesj	410	31	MID1	MID1	NNP
cord-000248-zueoyesj	410	32	)	)	-RRB-
cord-000248-zueoyesj	410	33	have	have	VBP
cord-000248-zueoyesj	410	34	been	be	VBN
cord-000248-zueoyesj	410	35	associated	associate	VBN
cord-000248-zueoyesj	410	36	to	to	IN
cord-000248-zueoyesj	410	37	the	the	DT
cord-000248-zueoyesj	410	38	Gene	Gene	NNP
cord-000248-zueoyesj	410	39	Ontology	Ontology	NNP
cord-000248-zueoyesj	410	40	term	term	NN
cord-000248-zueoyesj	410	41	of	of	IN
cord-000248-zueoyesj	410	42	'	'	``
cord-000248-zueoyesj	410	43	developmental	developmental	JJ
cord-000248-zueoyesj	410	44	process	process	NN
cord-000248-zueoyesj	410	45	'	'	''
cord-000248-zueoyesj	410	46	.	.	.
cord-000248-zueoyesj	411	1	SPP1	SPP1	NNP
cord-000248-zueoyesj	411	2	-Secreted	-Secreted	.
cord-000248-zueoyesj	412	1	phosphoprotein	phosphoprotein	NNP
cord-000248-zueoyesj	412	2	1	1	CD
cord-000248-zueoyesj	412	3	(	(	-LRB-
cord-000248-zueoyesj	412	4	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	412	5	)	)	-RRB-
cord-000248-zueoyesj	412	6	.	.	.
cord-000248-zueoyesj	413	1	SPP1	SPP1	NNP
cord-000248-zueoyesj	413	2	is	be	VBZ
cord-000248-zueoyesj	413	3	one	one	CD
cord-000248-zueoyesj	413	4	of	of	IN
cord-000248-zueoyesj	413	5	the	the	DT
cord-000248-zueoyesj	413	6	most	most	RBS
cord-000248-zueoyesj	413	7	conspicuous	conspicuous	JJ
cord-000248-zueoyesj	413	8	melanoma	melanoma	NN
cord-000248-zueoyesj	413	9	biomarkers	biomarker	NNS
cord-000248-zueoyesj	413	10	[	[	-LRB-
cord-000248-zueoyesj	413	11	198	198	CD
cord-000248-zueoyesj	413	12	,	,	,
cord-000248-zueoyesj	413	13	199	199	CD
cord-000248-zueoyesj	413	14	,	,	,
cord-000248-zueoyesj	413	15	200	200	CD
cord-000248-zueoyesj	413	16	,	,	,
cord-000248-zueoyesj	413	17	201	201	CD
cord-000248-zueoyesj	413	18	,	,	,
cord-000248-zueoyesj	413	19	202	202	CD
cord-000248-zueoyesj	413	20	,	,	,
cord-000248-zueoyesj	413	21	203	203	CD
cord-000248-zueoyesj	413	22	,	,	,
cord-000248-zueoyesj	413	23	204	204	CD
cord-000248-zueoyesj	413	24	,	,	,
cord-000248-zueoyesj	413	25	205	205	CD
cord-000248-zueoyesj	413	26	,	,	,
cord-000248-zueoyesj	413	27	206	206	CD
cord-000248-zueoyesj	413	28	,	,	,
cord-000248-zueoyesj	413	29	207	207	CD
cord-000248-zueoyesj	413	30	,	,	,
cord-000248-zueoyesj	413	31	208	208	CD
cord-000248-zueoyesj	413	32	,	,	,
cord-000248-zueoyesj	413	33	209	209	CD
cord-000248-zueoyesj	413	34	,	,	,
cord-000248-zueoyesj	413	35	210	210	CD
cord-000248-zueoyesj	413	36	,	,	,
cord-000248-zueoyesj	413	37	211	211	CD
cord-000248-zueoyesj	413	38	,	,	,
cord-000248-zueoyesj	413	39	212	212	CD
cord-000248-zueoyesj	413	40	,	,	,
cord-000248-zueoyesj	413	41	213	213	CD
cord-000248-zueoyesj	413	42	,	,	,
cord-000248-zueoyesj	413	43	214	214	CD
cord-000248-zueoyesj	413	44	,	,	,
cord-000248-zueoyesj	413	45	215	215	CD
cord-000248-zueoyesj	413	46	,	,	,
cord-000248-zueoyesj	413	47	216	216	CD
cord-000248-zueoyesj	413	48	,	,	,
cord-000248-zueoyesj	413	49	217	217	CD
cord-000248-zueoyesj	413	50	,	,	,
cord-000248-zueoyesj	413	51	218	218	CD
cord-000248-zueoyesj	413	52	,	,	,
cord-000248-zueoyesj	413	53	219	219	CD
cord-000248-zueoyesj	413	54	,	,	,
cord-000248-zueoyesj	413	55	220	220	CD
cord-000248-zueoyesj	413	56	,	,	,
cord-000248-zueoyesj	413	57	221	221	CD
cord-000248-zueoyesj	413	58	,	,	,
cord-000248-zueoyesj	413	59	222	222	CD
cord-000248-zueoyesj	413	60	]	]	-RRB-
cord-000248-zueoyesj	413	61	(	(	-LRB-
cord-000248-zueoyesj	413	62	see	see	VB
cord-000248-zueoyesj	413	63	also	also	RB
cord-000248-zueoyesj	413	64	the	the	DT
cord-000248-zueoyesj	413	65	references	reference	NNS
cord-000248-zueoyesj	413	66	cited	cite	VBN
cord-000248-zueoyesj	413	67	in	in	IN
cord-000248-zueoyesj	413	68	Figure	Figure	NNP
cord-000248-zueoyesj	413	69	6	6	CD
cord-000248-zueoyesj	413	70	and	and	CC
cord-000248-zueoyesj	413	71	note	note	VB
cord-000248-zueoyesj	413	72	its	-PRON-	PRP$
cord-000248-zueoyesj	413	73	eminent	eminent	JJ
cord-000248-zueoyesj	413	74	position	position	NN
cord-000248-zueoyesj	413	75	in	in	IN
cord-000248-zueoyesj	413	76	this	this	DT
cord-000248-zueoyesj	413	77	scatter	scatter	NN
cord-000248-zueoyesj	413	78	plot	plot	NN
cord-000248-zueoyesj	413	79	)	)	-RRB-
cord-000248-zueoyesj	413	80	.	.	.
cord-000248-zueoyesj	414	1	In	in	IN
cord-000248-zueoyesj	414	2	1990	1990	CD
cord-000248-zueoyesj	414	3	,	,	,
cord-000248-zueoyesj	414	4	Craig	Craig	NNP
cord-000248-zueoyesj	414	5	et	et	NNP
cord-000248-zueoyesj	414	6	al	al	NNP
cord-000248-zueoyesj	414	7	.	.	NNP
cord-000248-zueoyesj	414	8	reported	report	VBD
cord-000248-zueoyesj	414	9	that	that	IN
cord-000248-zueoyesj	414	10	SPP1	SPP1	NNP
cord-000248-zueoyesj	414	11	may	may	MD
cord-000248-zueoyesj	414	12	work	work	VB
cord-000248-zueoyesj	414	13	as	as	IN
cord-000248-zueoyesj	414	14	an	an	DT
cord-000248-zueoyesj	414	15	autocrine	autocrine	JJ
cord-000248-zueoyesj	414	16	adhesion	adhesion	NN
cord-000248-zueoyesj	414	17	factor	factor	NN
cord-000248-zueoyesj	414	18	for	for	IN
cord-000248-zueoyesj	414	19	tumor	tumor	NN
cord-000248-zueoyesj	414	20	cells	cell	NNS
cord-000248-zueoyesj	414	21	(	(	-LRB-
cord-000248-zueoyesj	414	22	see	see	VB
cord-000248-zueoyesj	414	23	also	also	RB
cord-000248-zueoyesj	414	24	[	[	-LRB-
cord-000248-zueoyesj	414	25	204	204	CD
cord-000248-zueoyesj	414	26	,	,	,
cord-000248-zueoyesj	414	27	223	223	CD
cord-000248-zueoyesj	414	28	,	,	,
cord-000248-zueoyesj	414	29	224	224	CD
cord-000248-zueoyesj	414	30	]	]	-RRB-
cord-000248-zueoyesj	414	31	)	)	-RRB-
cord-000248-zueoyesj	414	32	.	.	.
cord-000248-zueoyesj	415	1	They	-PRON-	PRP
cord-000248-zueoyesj	415	2	observed	observe	VBD
cord-000248-zueoyesj	415	3	that	that	DT
cord-000248-zueoyesj	415	4	''	''	''
cord-000248-zueoyesj	416	1	SPP1	SPP1	NNP
cord-000248-zueoyesj	416	2	mRNA	mRNA	NNP
cord-000248-zueoyesj	416	3	,	,	,
cord-000248-zueoyesj	416	4	which	which	WDT
cord-000248-zueoyesj	416	5	is	be	VBZ
cord-000248-zueoyesj	416	6	barely	barely	RB
cord-000248-zueoyesj	416	7	detectable	detectable	JJ
cord-000248-zueoyesj	416	8	in	in	IN
cord-000248-zueoyesj	416	9	normal	normal	JJ
cord-000248-zueoyesj	416	10	mouse	mouse	NN
cord-000248-zueoyesj	416	11	epidermis	epidermis	NN
cord-000248-zueoyesj	416	12	,	,	,
cord-000248-zueoyesj	416	13	was	be	VBD
cord-000248-zueoyesj	416	14	expressed	express	VBN
cord-000248-zueoyesj	416	15	at	at	IN
cord-000248-zueoyesj	416	16	moderate	moderate	JJ
cord-000248-zueoyesj	416	17	-	-	HYPH
cord-000248-zueoyesj	416	18	to	to	IN
cord-000248-zueoyesj	416	19	-	-	HYPH
cord-000248-zueoyesj	416	20	high	high	JJ
cord-000248-zueoyesj	416	21	levels	level	NNS
cord-000248-zueoyesj	416	22	in	in	IN
cord-000248-zueoyesj	416	23	2	2	CD
cord-000248-zueoyesj	416	24	of	of	IN
cord-000248-zueoyesj	416	25	3	3	CD
cord-000248-zueoyesj	416	26	epidermal	epidermal	JJ
cord-000248-zueoyesj	416	27	papillomas	papilloma	NNS
cord-000248-zueoyesj	416	28	and	and	CC
cord-000248-zueoyesj	416	29	at	at	IN
cord-000248-zueoyesj	416	30	consistently	consistently	RB
cord-000248-zueoyesj	416	31	high	high	JJ
cord-000248-zueoyesj	416	32	levels	level	NNS
cord-000248-zueoyesj	416	33	in	in	IN
cord-000248-zueoyesj	416	34	7	7	CD
cord-000248-zueoyesj	416	35	of	of	IN
cord-000248-zueoyesj	416	36	7	7	CD
cord-000248-zueoyesj	416	37	squamous	squamous	JJ
cord-000248-zueoyesj	416	38	-	-	HYPH
cord-000248-zueoyesj	416	39	cell	cell	NN
cord-000248-zueoyesj	416	40	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	416	41	induced	induce	VBN
cord-000248-zueoyesj	416	42	by	by	IN
cord-000248-zueoyesj	416	43	an	an	DT
cord-000248-zueoyesj	416	44	initiation	initiation	NN
cord-000248-zueoyesj	416	45	-	-	HYPH
cord-000248-zueoyesj	416	46	promotion	promotion	NN
cord-000248-zueoyesj	416	47	regimen	regimen	NN
cord-000248-zueoyesj	416	48	'	'	''
cord-000248-zueoyesj	416	49	'	'	''
cord-000248-zueoyesj	416	50	[	[	-LRB-
cord-000248-zueoyesj	416	51	225	225	CD
cord-000248-zueoyesj	416	52	]	]	-RRB-
cord-000248-zueoyesj	416	53	.	.	.
cord-000248-zueoyesj	417	1	The	the	DT
cord-000248-zueoyesj	417	2	evidence	evidence	NN
cord-000248-zueoyesj	417	3	is	be	VBZ
cord-000248-zueoyesj	417	4	being	be	VBG
cord-000248-zueoyesj	417	5	constantly	constantly	RB
cord-000248-zueoyesj	417	6	expanded	expand	VBN
cord-000248-zueoyesj	417	7	on	on	IN
cord-000248-zueoyesj	417	8	the	the	DT
cord-000248-zueoyesj	417	9	role	role	NN
cord-000248-zueoyesj	417	10	of	of	IN
cord-000248-zueoyesj	417	11	SPP1	SPP1	NNP
cord-000248-zueoyesj	417	12	as	as	IN
cord-000248-zueoyesj	417	13	a	a	DT
cord-000248-zueoyesj	417	14	molecular	molecular	JJ
cord-000248-zueoyesj	417	15	prognostic	prognostic	JJ
cord-000248-zueoyesj	417	16	biomarker	biomarker	NN
cord-000248-zueoyesj	417	17	in	in	IN
cord-000248-zueoyesj	417	18	melanoma	melanoma	NN
cord-000248-zueoyesj	417	19	[	[	-LRB-
cord-000248-zueoyesj	417	20	226	226	CD
cord-000248-zueoyesj	417	21	]	]	-RRB-
cord-000248-zueoyesj	417	22	.	.	.
cord-000248-zueoyesj	418	1	Activation	activation	NN
cord-000248-zueoyesj	418	2	of	of	IN
cord-000248-zueoyesj	418	3	SPP1	SPP1	NNPS
cord-000248-zueoyesj	418	4	may	may	MD
cord-000248-zueoyesj	418	5	be	be	VB
cord-000248-zueoyesj	418	6	an	an	DT
cord-000248-zueoyesj	418	7	important	important	JJ
cord-000248-zueoyesj	418	8	event	event	NN
cord-000248-zueoyesj	418	9	that	that	WDT
cord-000248-zueoyesj	418	10	allows	allow	VBZ
cord-000248-zueoyesj	418	11	the	the	DT
cord-000248-zueoyesj	418	12	transformed	transformed	JJ
cord-000248-zueoyesj	418	13	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	418	14	to	to	TO
cord-000248-zueoyesj	418	15	invade	invade	VB
cord-000248-zueoyesj	418	16	the	the	DT
cord-000248-zueoyesj	418	17	dermis	dermis	NN
cord-000248-zueoyesj	418	18	as	as	IN
cord-000248-zueoyesj	418	19	proposed	propose	VBN
cord-000248-zueoyesj	418	20	by	by	IN
cord-000248-zueoyesj	418	21	Geissinger	Geissinger	NNP
cord-000248-zueoyesj	418	22	et	et	NNP
cord-000248-zueoyesj	418	23	al	al	NNP
cord-000248-zueoyesj	418	24	.	.	.
cord-000248-zueoyesj	419	1	in	in	IN
cord-000248-zueoyesj	419	2	2002	2002	CD
cord-000248-zueoyesj	419	3	[	[	-LRB-
cord-000248-zueoyesj	419	4	208	208	CD
cord-000248-zueoyesj	419	5	]	]	-RRB-
cord-000248-zueoyesj	419	6	.	.	.
cord-000248-zueoyesj	420	1	This	this	DT
cord-000248-zueoyesj	420	2	causes	cause	VBZ
cord-000248-zueoyesj	420	3	SPP1	SPP1	NNS
cord-000248-zueoyesj	420	4	to	to	TO
cord-000248-zueoyesj	420	5	avoid	avoid	VB
cord-000248-zueoyesj	420	6	the	the	DT
cord-000248-zueoyesj	420	7	apoptotic	apoptotic	JJ
cord-000248-zueoyesj	420	8	stimulus	stimulus	NN
cord-000248-zueoyesj	420	9	,	,	,
cord-000248-zueoyesj	420	10	one	one	CD
cord-000248-zueoyesj	420	11	of	of	IN
cord-000248-zueoyesj	420	12	the	the	DT
cord-000248-zueoyesj	420	13	'	'	``
cord-000248-zueoyesj	420	14	'	'	``
cord-000248-zueoyesj	420	15	hallmarks	hallmark	NNS
cord-000248-zueoyesj	420	16	of	of	IN
cord-000248-zueoyesj	420	17	cancer	cancer	NN
cord-000248-zueoyesj	420	18	'	'	''
cord-000248-zueoyesj	420	19	'	'	''
cord-000248-zueoyesj	420	20	,	,	,
cord-000248-zueoyesj	420	21	which	which	WDT
cord-000248-zueoyesj	420	22	invasive	invasive	JJ
cord-000248-zueoyesj	420	23	cells	cell	NNS
cord-000248-zueoyesj	420	24	will	will	MD
cord-000248-zueoyesj	420	25	be	be	VB
cord-000248-zueoyesj	420	26	receiving	receive	VBG
cord-000248-zueoyesj	420	27	from	from	IN
cord-000248-zueoyesj	420	28	this	this	DT
cord-000248-zueoyesj	420	29	new	new	JJ
cord-000248-zueoyesj	420	30	tissue	tissue	NN
cord-000248-zueoyesj	420	31	.	.	.
cord-000248-zueoyesj	421	1	If	if	IN
cord-000248-zueoyesj	421	2	we	-PRON-	PRP
cord-000248-zueoyesj	421	3	extend	extend	VBP
cord-000248-zueoyesj	421	4	the	the	DT
cord-000248-zueoyesj	421	5	literature	literature	NN
cord-000248-zueoyesj	421	6	-	-	HYPH
cord-000248-zueoyesj	421	7	based	base	VBN
cord-000248-zueoyesj	421	8	search	search	NN
cord-000248-zueoyesj	421	9	so	so	IN
cord-000248-zueoyesj	421	10	that	that	IN
cord-000248-zueoyesj	421	11	we	-PRON-	PRP
cord-000248-zueoyesj	421	12	now	now	RB
cord-000248-zueoyesj	421	13	include	include	VBP
cord-000248-zueoyesj	421	14	the	the	DT
cord-000248-zueoyesj	421	15	first	first	JJ
cord-000248-zueoyesj	421	16	200	200	CD
cord-000248-zueoyesj	421	17	gene	gene	NN
cord-000248-zueoyesj	421	18	probes	probe	NNS
cord-000248-zueoyesj	421	19	recognized	recognize	VBN
cord-000248-zueoyesj	421	20	by	by	IN
cord-000248-zueoyesj	421	21	GATHER	gather	NN
cord-000248-zueoyesj	421	22	then	then	RB
cord-000248-zueoyesj	421	23	we	-PRON-	PRP
cord-000248-zueoyesj	421	24	have	have	VBP
cord-000248-zueoyesj	421	25	27	27	CD
cord-000248-zueoyesj	421	26	gene	gene	NN
cord-000248-zueoyesj	421	27	probes	probe	NNS
cord-000248-zueoyesj	421	28	associated	associate	VBN
cord-000248-zueoyesj	421	29	with	with	IN
cord-000248-zueoyesj	421	30	the	the	DT
cord-000248-zueoyesj	421	31	Gene	Gene	NNP
cord-000248-zueoyesj	421	32	Ontology	Ontology	NNP
cord-000248-zueoyesj	421	33	in	in	IN
cord-000248-zueoyesj	421	34	terms	term	NNS
cord-000248-zueoyesj	421	35	of	of	IN
cord-000248-zueoyesj	421	36	'	'	''
cord-000248-zueoyesj	421	37	'	'	''
cord-000248-zueoyesj	421	38	cell	cell	NN
cord-000248-zueoyesj	421	39	proliferation	proliferation	NN
cord-000248-zueoyesj	421	40	'	'	''
cord-000248-zueoyesj	421	41	'	'	''
cord-000248-zueoyesj	421	42	(	(	-LRB-
cord-000248-zueoyesj	421	43	p	p	NN
cord-000248-zueoyesj	421	44	-	-	HYPH
cord-000248-zueoyesj	421	45	value	value	NN
cord-000248-zueoyesj	421	46	=	=	SYM
cord-000248-zueoyesj	421	47	0.0002	0.0002	CD
cord-000248-zueoyesj	421	48	,	,	,
cord-000248-zueoyesj	421	49	Bayes	Bayes	NNP
cord-000248-zueoyesj	421	50	Factor	Factor	NNP
cord-000248-zueoyesj	421	51	5	5	CD
cord-000248-zueoyesj	421	52	)	)	-RRB-
cord-000248-zueoyesj	421	53	,	,	,
cord-000248-zueoyesj	421	54	and	and	CC
cord-000248-zueoyesj	421	55	'	'	``
cord-000248-zueoyesj	421	56	regulation	regulation	NN
cord-000248-zueoyesj	421	57	of	of	IN
cord-000248-zueoyesj	421	58	cell	cell	NN
cord-000248-zueoyesj	421	59	proliferation	proliferation	NN
cord-000248-zueoyesj	421	60	'	'	''
cord-000248-zueoyesj	421	61	,	,	,
cord-000248-zueoyesj	421	62	p	p	NN
cord-000248-zueoyesj	421	63	-	-	HYPH
cord-000248-zueoyesj	421	64	value	value	NN
cord-000248-zueoyesj	421	65	=	=	SYM
cord-000248-zueoyesj	421	66	0.003	0.003	CD
cord-000248-zueoyesj	421	67	,	,	,
cord-000248-zueoyesj	421	68	Bayes	Bayes	NNP
cord-000248-zueoyesj	421	69	factor	factor	NN
cord-000248-zueoyesj	421	70	3	3	CD
cord-000248-zueoyesj	421	71	)	)	-RRB-
cord-000248-zueoyesj	421	72	.	.	.
cord-000248-zueoyesj	422	1	However	however	RB
cord-000248-zueoyesj	422	2	,	,	,
cord-000248-zueoyesj	422	3	other	other	JJ
cord-000248-zueoyesj	422	4	partners	partner	NNS
cord-000248-zueoyesj	422	5	of	of	IN
cord-000248-zueoyesj	422	6	PLK1	PLK1	NNP
cord-000248-zueoyesj	422	7	appear	appear	VBP
cord-000248-zueoyesj	422	8	and	and	CC
cord-000248-zueoyesj	422	9	their	-PRON-	PRP$
cord-000248-zueoyesj	422	10	function	function	NN
cord-000248-zueoyesj	422	11	in	in	IN
cord-000248-zueoyesj	422	12	'	'	``
cord-000248-zueoyesj	422	13	mitotic	mitotic	JJ
cord-000248-zueoyesj	422	14	cell	cell	NN
cord-000248-zueoyesj	422	15	cycle	cycle	NN
cord-000248-zueoyesj	422	16	'	'	''
cord-000248-zueoyesj	422	17	(	(	-LRB-
cord-000248-zueoyesj	422	18	pvalue	pvalue	NNP
cord-000248-zueoyesj	422	19	=	=	SYM
cord-000248-zueoyesj	422	20	0.0003	0.0003	CD
cord-000248-zueoyesj	422	21	,	,	,
cord-000248-zueoyesj	422	22	Bayes	Bayes	NNP
cord-000248-zueoyesj	422	23	Factor	Factor	NNP
cord-000248-zueoyesj	422	24	5	5	CD
cord-000248-zueoyesj	422	25	)	)	-RRB-
cord-000248-zueoyesj	422	26	is	be	VBZ
cord-000248-zueoyesj	422	27	increasingly	increasingly	RB
cord-000248-zueoyesj	422	28	present	present	JJ
cord-000248-zueoyesj	422	29	(	(	-LRB-
cord-000248-zueoyesj	422	30	in	in	IN
cord-000248-zueoyesj	422	31	particular	particular	JJ
cord-000248-zueoyesj	422	32	,	,	,
cord-000248-zueoyesj	422	33	the	the	DT
cord-000248-zueoyesj	422	34	M	M	NNP
cord-000248-zueoyesj	422	35	phase	phase	NN
cord-000248-zueoyesj	422	36	of	of	IN
cord-000248-zueoyesj	422	37	the	the	DT
cord-000248-zueoyesj	422	38	mitotic	mitotic	JJ
cord-000248-zueoyesj	422	39	cell	cell	NN
cord-000248-zueoyesj	422	40	cycle	cycle	NN
cord-000248-zueoyesj	422	41	)	)	-RRB-
cord-000248-zueoyesj	422	42	.	.	.
cord-000248-zueoyesj	423	1	The	the	DT
cord-000248-zueoyesj	423	2	details	detail	NNS
cord-000248-zueoyesj	423	3	of	of	IN
cord-000248-zueoyesj	423	4	the	the	DT
cord-000248-zueoyesj	423	5	Gene	Gene	NNP
cord-000248-zueoyesj	423	6	Ontology	Ontology	NNP
cord-000248-zueoyesj	423	7	terms	term	NNS
cord-000248-zueoyesj	423	8	which	which	WDT
cord-000248-zueoyesj	423	9	are	be	VBP
cord-000248-zueoyesj	423	10	significant	significant	JJ
cord-000248-zueoyesj	423	11	and	and	CC
cord-000248-zueoyesj	423	12	the	the	DT
cord-000248-zueoyesj	423	13	genes	gene	NNS
cord-000248-zueoyesj	423	14	associated	associate	VBN
cord-000248-zueoyesj	423	15	to	to	IN
cord-000248-zueoyesj	423	16	them	-PRON-	PRP
cord-000248-zueoyesj	423	17	are	be	VBP
cord-000248-zueoyesj	423	18	listed	list	VBN
cord-000248-zueoyesj	423	19	in	in	IN
cord-000248-zueoyesj	423	20	Table	Table	NNP
cord-000248-zueoyesj	423	21	2	2	CD
cord-000248-zueoyesj	423	22	.	.	.
cord-000248-zueoyesj	424	1	The	the	DT
cord-000248-zueoyesj	424	2	analysis	analysis	NN
cord-000248-zueoyesj	424	3	using	use	VBG
cord-000248-zueoyesj	424	4	g	g	NN
cord-000248-zueoyesj	424	5	:	:	:
cord-000248-zueoyesj	424	6	Profiler	profiler	NN
cord-000248-zueoyesj	424	7	largely	largely	RB
cord-000248-zueoyesj	424	8	coincides	coincide	VBZ
cord-000248-zueoyesj	424	9	with	with	IN
cord-000248-zueoyesj	424	10	the	the	DT
cord-000248-zueoyesj	424	11	analysis	analysis	NN
cord-000248-zueoyesj	424	12	using	use	VBG
cord-000248-zueoyesj	424	13	GATHER	gather	VB
cord-000248-zueoyesj	424	14	,	,	,
cord-000248-zueoyesj	424	15	however	however	RB
cord-000248-zueoyesj	424	16	,	,	,
cord-000248-zueoyesj	424	17	it	-PRON-	PRP
cord-000248-zueoyesj	424	18	retrieves	retrieve	VBZ
cord-000248-zueoyesj	424	19	12	12	CD
cord-000248-zueoyesj	424	20	genes	gene	NNS
cord-000248-zueoyesj	424	21	associated	associate	VBN
cord-000248-zueoyesj	424	22	with	with	IN
cord-000248-zueoyesj	424	23	the	the	DT
cord-000248-zueoyesj	424	24	M	M	NNP
cord-000248-zueoyesj	424	25	phase	phase	NN
cord-000248-zueoyesj	424	26	of	of	IN
cord-000248-zueoyesj	424	27	mitotic	mitotic	JJ
cord-000248-zueoyesj	424	28	cell	cell	NN
cord-000248-zueoyesj	424	29	cycle	cycle	NN
cord-000248-zueoyesj	424	30	,	,	,
cord-000248-zueoyesj	424	31	namely	namely	RB
cord-000248-zueoyesj	424	32	:	:	:
cord-000248-zueoyesj	424	33	AURKA	AURKA	NNP
cord-000248-zueoyesj	424	34	and	and	CC
cord-000248-zueoyesj	424	35	AURKB	AURKB	NNP
cord-000248-zueoyesj	424	36	[	[	-LRB-
cord-000248-zueoyesj	424	37	227	227	CD
cord-000248-zueoyesj	424	38	,	,	,
cord-000248-zueoyesj	424	39	228	228	CD
cord-000248-zueoyesj	424	40	,	,	,
cord-000248-zueoyesj	424	41	229	229	CD
cord-000248-zueoyesj	424	42	]	]	-RRB-
cord-000248-zueoyesj	424	43	,	,	.
cord-000248-zueoyesj	425	1	BUB1	BUB1	NNP
cord-000248-zueoyesj	425	2	[	[	-LRB-
cord-000248-zueoyesj	425	3	230	230	CD
cord-000248-zueoyesj	425	4	,	,	,
cord-000248-zueoyesj	425	5	231	231	CD
cord-000248-zueoyesj	425	6	]	]	-RRB-
cord-000248-zueoyesj	425	7	,	,	,
cord-000248-zueoyesj	425	8	CDCA5A	CDCA5A	NNP
cord-000248-zueoyesj	425	9	/	/	SYM
cord-000248-zueoyesj	425	10	Sororin	Sororin	NNP
cord-000248-zueoyesj	425	11	/	/	SYM
cord-000248-zueoyesj	425	12	p35	p35	CD
cord-000248-zueoyesj	425	13	[	[	-LRB-
cord-000248-zueoyesj	425	14	232	232	CD
cord-000248-zueoyesj	425	15	]	]	-RRB-
cord-000248-zueoyesj	425	16	,	,	,
cord-000248-zueoyesj	425	17	CDC7	CDC7	NNP
cord-000248-zueoyesj	425	18	[	[	-LRB-
cord-000248-zueoyesj	425	19	233	233	CD
cord-000248-zueoyesj	425	20	,	,	,
cord-000248-zueoyesj	425	21	234	234	CD
cord-000248-zueoyesj	425	22	]	]	-RRB-
cord-000248-zueoyesj	425	23	,	,	,
cord-000248-zueoyesj	425	24	CHEK1	CHEK1	NNP
cord-000248-zueoyesj	425	25	[	[	-LRB-
cord-000248-zueoyesj	425	26	235	235	CD
cord-000248-zueoyesj	425	27	]	]	-RRB-
cord-000248-zueoyesj	425	28	,	,	,
cord-000248-zueoyesj	425	29	KIF23	KIF23	NNP
cord-000248-zueoyesj	425	30	/	/	SYM
cord-000248-zueoyesj	425	31	MKLP-1	MKLP-1	NNP
cord-000248-zueoyesj	425	32	[	[	-LRB-
cord-000248-zueoyesj	425	33	227	227	CD
cord-000248-zueoyesj	425	34	,	,	,
cord-000248-zueoyesj	425	35	236	236	CD
cord-000248-zueoyesj	425	36	,	,	,
cord-000248-zueoyesj	425	37	237	237	CD
cord-000248-zueoyesj	425	38	]	]	-RRB-
cord-000248-zueoyesj	425	39	,	,	,
cord-000248-zueoyesj	425	40	MAP9/	MAP9/	NNP
cord-000248-zueoyesj	426	1	ASAP	ASAP	NNP
cord-000248-zueoyesj	426	2	[	[	-LRB-
cord-000248-zueoyesj	426	3	238	238	CD
cord-000248-zueoyesj	426	4	,	,	,
cord-000248-zueoyesj	426	5	239	239	CD
cord-000248-zueoyesj	426	6	]	]	-RRB-
cord-000248-zueoyesj	426	7	,	,	,
cord-000248-zueoyesj	426	8	NCAPD3	ncapd3	CD
cord-000248-zueoyesj	426	9	,	,	,
cord-000248-zueoyesj	427	1	NCAPG2	ncapg2	UH
cord-000248-zueoyesj	428	1	[	[	-LRB-
cord-000248-zueoyesj	428	2	240	240	CD
cord-000248-zueoyesj	428	3	]	]	-RRB-
cord-000248-zueoyesj	428	4	,	,	.
cord-000248-zueoyesj	429	1	NEK6	NEK6	NNP
cord-000248-zueoyesj	429	2	[	[	-LRB-
cord-000248-zueoyesj	429	3	241	241	CD
cord-000248-zueoyesj	429	4	,	,	,
cord-000248-zueoyesj	429	5	242	242	CD
cord-000248-zueoyesj	429	6	,	,	,
cord-000248-zueoyesj	429	7	243	243	CD
cord-000248-zueoyesj	429	8	,	,	,
cord-000248-zueoyesj	429	9	244	244	CD
cord-000248-zueoyesj	429	10	]	]	-RRB-
cord-000248-zueoyesj	429	11	,	,	,
cord-000248-zueoyesj	429	12	PLK1	PLK1	NNP
cord-000248-zueoyesj	429	13	[	[	-LRB-
cord-000248-zueoyesj	429	14	147	147	CD
cord-000248-zueoyesj	429	15	,	,	,
cord-000248-zueoyesj	429	16	245	245	CD
cord-000248-zueoyesj	429	17	,	,	,
cord-000248-zueoyesj	429	18	246	246	CD
cord-000248-zueoyesj	429	19	]	]	-RRB-
cord-000248-zueoyesj	429	20	,	,	,
cord-000248-zueoyesj	429	21	PTTG1	PTTG1	NNS
cord-000248-zueoyesj	429	22	/	/	SYM
cord-000248-zueoyesj	429	23	Securin	Securin	NNP
cord-000248-zueoyesj	429	24	[	[	-LRB-
cord-000248-zueoyesj	429	25	247	247	CD
cord-000248-zueoyesj	429	26	]	]	-RRB-
cord-000248-zueoyesj	429	27	,	,	,
cord-000248-zueoyesj	429	28	SHC1	SHC1	NNP
cord-000248-zueoyesj	429	29	/	/	SYM
cord-000248-zueoyesj	429	30	p66	p66	XX
cord-000248-zueoyesj	429	31	[	[	-LRB-
cord-000248-zueoyesj	429	32	248	248	CD
cord-000248-zueoyesj	429	33	,	,	,
cord-000248-zueoyesj	429	34	249	249	CD
cord-000248-zueoyesj	429	35	,	,	,
cord-000248-zueoyesj	429	36	250	250	CD
cord-000248-zueoyesj	429	37	]	]	-RRB-
cord-000248-zueoyesj	430	1	(	(	-LRB-
cord-000248-zueoyesj	430	2	discussed	discuss	VBN
cord-000248-zueoyesj	430	3	in	in	IN
cord-000248-zueoyesj	430	4	the	the	DT
cord-000248-zueoyesj	430	5	context	context	NN
cord-000248-zueoyesj	430	6	of	of	IN
cord-000248-zueoyesj	430	7	SHC4	SHC4	NNP
cord-000248-zueoyesj	430	8	signalling	signalling	NN
cord-000248-zueoyesj	430	9	)	)	-RRB-
cord-000248-zueoyesj	430	10	,	,	,
cord-000248-zueoyesj	430	11	and	and	CC
cord-000248-zueoyesj	430	12	TFDP1	TFDP1	NNP
cord-000248-zueoyesj	430	13	/	/	SYM
cord-000248-zueoyesj	430	14	DP-1	DP-1	NNP
cord-000248-zueoyesj	430	15	[	[	-LRB-
cord-000248-zueoyesj	430	16	251	251	CD
cord-000248-zueoyesj	430	17	]	]	-RRB-
cord-000248-zueoyesj	430	18	.	.	.
cord-000248-zueoyesj	431	1	These	these	DT
cord-000248-zueoyesj	431	2	are	be	VBP
cord-000248-zueoyesj	431	3	a	a	DT
cord-000248-zueoyesj	431	4	significant	significant	JJ
cord-000248-zueoyesj	431	5	finding	finding	NN
cord-000248-zueoyesj	431	6	by	by	IN
cord-000248-zueoyesj	431	7	g	g	NN
cord-000248-zueoyesj	431	8	:	:	:
cord-000248-zueoyesj	431	9	Profiler	profiler	NN
cord-000248-zueoyesj	431	10	(	(	-LRB-
cord-000248-zueoyesj	431	11	p	p	NN
cord-000248-zueoyesj	431	12	-	-	HYPH
cord-000248-zueoyesj	431	13	value	value	NN
cord-000248-zueoyesj	431	14	=	=	SYM
cord-000248-zueoyesj	431	15	4.03E-07	4.03e-07	CD
cord-000248-zueoyesj	431	16	)	)	-RRB-
cord-000248-zueoyesj	431	17	.	.	.
cord-000248-zueoyesj	432	1	We	-PRON-	PRP
cord-000248-zueoyesj	432	2	have	have	VBP
cord-000248-zueoyesj	432	3	listed	list	VBN
cord-000248-zueoyesj	432	4	above	above	IN
cord-000248-zueoyesj	432	5	some	some	DT
cord-000248-zueoyesj	432	6	of	of	IN
cord-000248-zueoyesj	432	7	the	the	DT
cord-000248-zueoyesj	432	8	genes	gene	NNS
cord-000248-zueoyesj	432	9	gene	gene	NN
cord-000248-zueoyesj	432	10	associated	associate	VBN
cord-000248-zueoyesj	432	11	to	to	IN
cord-000248-zueoyesj	432	12	the	the	DT
cord-000248-zueoyesj	432	13	M	M	NNP
cord-000248-zueoyesj	432	14	phase	phase	NN
cord-000248-zueoyesj	432	15	of	of	IN
cord-000248-zueoyesj	432	16	mitotic	mitotic	JJ
cord-000248-zueoyesj	432	17	cell	cell	NN
cord-000248-zueoyesj	432	18	cycle	cycle	NN
cord-000248-zueoyesj	432	19	and	and	CC
cord-000248-zueoyesj	432	20	associated	associated	JJ
cord-000248-zueoyesj	432	21	references	reference	NNS
cord-000248-zueoyesj	432	22	which	which	WDT
cord-000248-zueoyesj	432	23	are	be	VBP
cord-000248-zueoyesj	432	24	either	either	DT
cord-000248-zueoyesj	432	25	to	to	IN
cord-000248-zueoyesj	432	26	current	current	JJ
cord-000248-zueoyesj	432	27	research	research	NN
cord-000248-zueoyesj	432	28	in	in	IN
cord-000248-zueoyesj	432	29	melanoma	melanoma	NN
cord-000248-zueoyesj	432	30	and/or	and/or	CC
cord-000248-zueoyesj	432	31	its	-PRON-	PRP$
cord-000248-zueoyesj	432	32	biological	biological	JJ
cord-000248-zueoyesj	432	33	function	function	NN
cord-000248-zueoyesj	432	34	.	.	.
cord-000248-zueoyesj	433	1	We	-PRON-	PRP
cord-000248-zueoyesj	433	2	now	now	RB
cord-000248-zueoyesj	433	3	list	list	VBP
cord-000248-zueoyesj	433	4	other	other	JJ
cord-000248-zueoyesj	433	5	genes	gene	NNS
cord-000248-zueoyesj	433	6	which	which	WDT
cord-000248-zueoyesj	433	7	have	have	VBP
cord-000248-zueoyesj	433	8	been	be	VBN
cord-000248-zueoyesj	433	9	associated	associate	VBN
cord-000248-zueoyesj	433	10	with	with	IN
cord-000248-zueoyesj	433	11	the	the	DT
cord-000248-zueoyesj	433	12	term	term	NN
cord-000248-zueoyesj	433	13	'	'	``
cord-000248-zueoyesj	433	14	cell	cell	NN
cord-000248-zueoyesj	433	15	proliferation	proliferation	NN
cord-000248-zueoyesj	433	16	'	'	''
cord-000248-zueoyesj	433	17	by	by	IN
cord-000248-zueoyesj	433	18	GATHER	gather	NN
cord-000248-zueoyesj	433	19	.	.	.
cord-000248-zueoyesj	434	1	These	these	DT
cord-000248-zueoyesj	434	2	genes	gene	NNS
cord-000248-zueoyesj	434	3	are	be	VBP
cord-000248-zueoyesj	434	4	:	:	:
cord-000248-zueoyesj	434	5	ARPC1B	ARPC1B	NNP
cord-000248-zueoyesj	434	6	[	[	-LRB-
cord-000248-zueoyesj	434	7	252	252	CD
cord-000248-zueoyesj	434	8	]	]	-RRB-
cord-000248-zueoyesj	434	9	,	,	,
cord-000248-zueoyesj	434	10	ARPC2	ARPC2	NNP
cord-000248-zueoyesj	434	11	(	(	-LRB-
cord-000248-zueoyesj	434	12	which	which	WDT
cord-000248-zueoyesj	434	13	,	,	,
cord-000248-zueoyesj	434	14	together	together	RB
cord-000248-zueoyesj	434	15	with	with	IN
cord-000248-zueoyesj	434	16	SPP1	SPP1	NNS
cord-000248-zueoyesj	434	17	,	,	,
cord-000248-zueoyesj	434	18	is	be	VBZ
cord-000248-zueoyesj	434	19	also	also	RB
cord-000248-zueoyesj	434	20	in	in	IN
cord-000248-zueoyesj	434	21	the	the	DT
cord-000248-zueoyesj	434	22	novel	novel	JJ
cord-000248-zueoyesj	434	23	5-biomarker	5-biomarker	CD
cord-000248-zueoyesj	434	24	panel	panel	NN
cord-000248-zueoyesj	434	25	of	of	IN
cord-000248-zueoyesj	434	26	Kashani	Kashani	NNP
cord-000248-zueoyesj	434	27	-	-	HYPH
cord-000248-zueoyesj	434	28	Sabet	Sabet	NNP
cord-000248-zueoyesj	434	29	et	et	NNP
cord-000248-zueoyesj	434	30	al	al	NNP
cord-000248-zueoyesj	434	31	.	.	.
cord-000248-zueoyesj	435	1	[	[	-LRB-
cord-000248-zueoyesj	435	2	253	253	CD
cord-000248-zueoyesj	435	3	]	]	-RRB-
cord-000248-zueoyesj	435	4	)	)	-RRB-
cord-000248-zueoyesj	435	5	,	,	,
cord-000248-zueoyesj	435	6	BCCIP	BCCIP	NNP
cord-000248-zueoyesj	435	7	(	(	-LRB-
cord-000248-zueoyesj	435	8	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	435	9	and	and	CC
cord-000248-zueoyesj	435	10	CDKN1A	cdkn1a	NN
cord-000248-zueoyesj	435	11	-	-	HYPH
cord-000248-zueoyesj	435	12	interacting	interact	VBG
cord-000248-zueoyesj	435	13	protein)/P21-and	protein)/p21-and	NN
cord-000248-zueoyesj	435	14	CDK-	CDK-	NNP
cord-000248-zueoyesj	435	15	Figure	Figure	NNP
cord-000248-zueoyesj	435	16	10	10	CD
cord-000248-zueoyesj	435	17	.	.	.
cord-000248-zueoyesj	436	1	Expression	expression	NN
cord-000248-zueoyesj	436	2	of	of	IN
cord-000248-zueoyesj	436	3	a	a	DT
cord-000248-zueoyesj	436	4	probe	probe	NN
cord-000248-zueoyesj	436	5	for	for	IN
cord-000248-zueoyesj	436	6	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	437	1	(	(	-LRB-
cord-000248-zueoyesj	437	2	Claudin	Claudin	NNP
cord-000248-zueoyesj	437	3	1	1	CD
cord-000248-zueoyesj	437	4	)	)	-RRB-
cord-000248-zueoyesj	437	5	(	(	-LRB-
cord-000248-zueoyesj	437	6	y	y	NN
cord-000248-zueoyesj	437	7	-	-	HYPH
cord-000248-zueoyesj	437	8	axis	axis	NN
cord-000248-zueoyesj	437	9	)	)	-RRB-
cord-000248-zueoyesj	437	10	as	as	IN
cord-000248-zueoyesj	437	11	a	a	DT
cord-000248-zueoyesj	437	12	function	function	NN
cord-000248-zueoyesj	437	13	of	of	IN
cord-000248-zueoyesj	437	14	a	a	DT
cord-000248-zueoyesj	437	15	probe	probe	NN
cord-000248-zueoyesj	437	16	for	for	IN
cord-000248-zueoyesj	437	17	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	437	18	3	3	CD
cord-000248-zueoyesj	437	19	(	(	-LRB-
cord-000248-zueoyesj	437	20	x	x	NN
cord-000248-zueoyesj	437	21	-	-	NN
cord-000248-zueoyesj	437	22	axis	axis	NN
cord-000248-zueoyesj	437	23	)	)	-RRB-
cord-000248-zueoyesj	437	24	.	.	.
cord-000248-zueoyesj	438	1	Other	other	JJ
cord-000248-zueoyesj	438	2	members	member	NNS
cord-000248-zueoyesj	438	3	of	of	IN
cord-000248-zueoyesj	438	4	the	the	DT
cord-000248-zueoyesj	438	5	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	438	6	family	family	NN
cord-000248-zueoyesj	438	7	of	of	IN
cord-000248-zueoyesj	438	8	proteins	protein	NNS
cord-000248-zueoyesj	438	9	have	have	VBP
cord-000248-zueoyesj	438	10	a	a	DT
cord-000248-zueoyesj	438	11	similar	similar	JJ
cord-000248-zueoyesj	438	12	behaviour	behaviour	NN
cord-000248-zueoyesj	438	13	.	.	.
cord-000248-zueoyesj	439	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	439	2	,	,	,
cord-000248-zueoyesj	439	3	together	together	RB
cord-000248-zueoyesj	439	4	with	with	IN
cord-000248-zueoyesj	439	5	CLDN1	CLDN1	NNS
cord-000248-zueoyesj	439	6	are	be	VBP
cord-000248-zueoyesj	439	7	key	key	JJ
cord-000248-zueoyesj	439	8	components	component	NNS
cord-000248-zueoyesj	439	9	of	of	IN
cord-000248-zueoyesj	439	10	the	the	DT
cord-000248-zueoyesj	439	11	tight	tight	JJ
cord-000248-zueoyesj	439	12	junction	junction	NN
cord-000248-zueoyesj	439	13	complexes	complex	NNS
cord-000248-zueoyesj	439	14	of	of	IN
cord-000248-zueoyesj	439	15	the	the	DT
cord-000248-zueoyesj	439	16	epidermis	epidermis	NN
cord-000248-zueoyesj	439	17	and	and	CC
cord-000248-zueoyesj	439	18	their	-PRON-	PRP$
cord-000248-zueoyesj	439	19	joint	joint	JJ
cord-000248-zueoyesj	439	20	loss	loss	NN
cord-000248-zueoyesj	439	21	of	of	IN
cord-000248-zueoyesj	439	22	expression	expression	NN
cord-000248-zueoyesj	439	23	seem	seem	VBP
cord-000248-zueoyesj	439	24	to	to	TO
cord-000248-zueoyesj	439	25	be	be	VB
cord-000248-zueoyesj	439	26	related	relate	VBN
cord-000248-zueoyesj	439	27	to	to	IN
cord-000248-zueoyesj	439	28	a	a	DT
cord-000248-zueoyesj	439	29	transition	transition	NN
cord-000248-zueoyesj	439	30	to	to	IN
cord-000248-zueoyesj	439	31	a	a	DT
cord-000248-zueoyesj	439	32	more	more	RBR
cord-000248-zueoyesj	439	33	malignant	malignant	JJ
cord-000248-zueoyesj	439	34	phenotype	phenotype	NN
cord-000248-zueoyesj	439	35	.	.	.
cord-000248-zueoyesj	440	1	We	-PRON-	PRP
cord-000248-zueoyesj	440	2	use	use	VBP
cord-000248-zueoyesj	440	3	the	the	DT
cord-000248-zueoyesj	440	4	same	same	JJ
cord-000248-zueoyesj	440	5	color	color	NN
cord-000248-zueoyesj	440	6	coding	coding	NN
cord-000248-zueoyesj	440	7	as	as	IN
cord-000248-zueoyesj	440	8	Figure	figure	NN
cord-000248-zueoyesj	440	9	9	9	CD
cord-000248-zueoyesj	440	10	.	.	.
cord-000248-zueoyesj	441	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	442	1	/journal.pone.0012262.g010	/journal.pone.0012262.g010	:
cord-000248-zueoyesj	442	2	associated	associated	JJ
cord-000248-zueoyesj	442	3	protein	protein	NN
cord-000248-zueoyesj	442	4	1	1	CD
cord-000248-zueoyesj	442	5	)	)	-RRB-
cord-000248-zueoyesj	442	6	[	[	-LRB-
cord-000248-zueoyesj	442	7	254	254	CD
cord-000248-zueoyesj	442	8	]	]	-RRB-
cord-000248-zueoyesj	442	9	,	,	.
cord-000248-zueoyesj	443	1	BST2	BST2	NNP
cord-000248-zueoyesj	443	2	/	/	SYM
cord-000248-zueoyesj	443	3	Bone	Bone	NNP
cord-000248-zueoyesj	443	4	marrow	marrow	NN
cord-000248-zueoyesj	443	5	stromal	stromal	NN
cord-000248-zueoyesj	443	6	antigen	antigen	NN
cord-000248-zueoyesj	443	7	2	2	CD
cord-000248-zueoyesj	443	8	/	/	SYM
cord-000248-zueoyesj	443	9	Tetherin	Tetherin	NNP
cord-000248-zueoyesj	443	10	[	[	-LRB-
cord-000248-zueoyesj	443	11	255	255	CD
cord-000248-zueoyesj	443	12	]	]	-RRB-
cord-000248-zueoyesj	443	13	,	,	.
cord-000248-zueoyesj	444	1	CCL3	CCL3	NNP
cord-000248-zueoyesj	444	2	/	/	SYM
cord-000248-zueoyesj	444	3	MIP-1alpha	MIP-1alpha	NNP
cord-000248-zueoyesj	444	4	[	[	-LRB-
cord-000248-zueoyesj	444	5	256	256	CD
cord-000248-zueoyesj	444	6	,	,	,
cord-000248-zueoyesj	444	7	257	257	CD
cord-000248-zueoyesj	444	8	,	,	,
cord-000248-zueoyesj	444	9	258	258	CD
cord-000248-zueoyesj	444	10	]	]	-RRB-
cord-000248-zueoyesj	445	1	,	,	,
cord-000248-zueoyesj	445	2	CCT4	CCT4	NNP
cord-000248-zueoyesj	445	3	,	,	,
cord-000248-zueoyesj	445	4	CDCA5	CDCA5	NNP
cord-000248-zueoyesj	445	5	/	/	SYM
cord-000248-zueoyesj	445	6	Sororin	Sororin	NNP
cord-000248-zueoyesj	445	7	[	[	-LRB-
cord-000248-zueoyesj	445	8	259	259	CD
cord-000248-zueoyesj	445	9	,	,	,
cord-000248-zueoyesj	445	10	260	260	CD
cord-000248-zueoyesj	445	11	,	,	,
cord-000248-zueoyesj	445	12	261	261	CD
cord-000248-zueoyesj	445	13	,	,	,
cord-000248-zueoyesj	445	14	262	262	CD
cord-000248-zueoyesj	445	15	,	,	,
cord-000248-zueoyesj	445	16	263	263	CD
cord-000248-zueoyesj	445	17	]	]	-RRB-
cord-000248-zueoyesj	445	18	,	,	.
cord-000248-zueoyesj	446	1	CENPF	CENPF	NNP
cord-000248-zueoyesj	446	2	/	/	SYM
cord-000248-zueoyesj	446	3	Mitosin	Mitosin	NNP
cord-000248-zueoyesj	446	4	[	[	-LRB-
cord-000248-zueoyesj	446	5	264	264	CD
cord-000248-zueoyesj	446	6	]	]	-RRB-
cord-000248-zueoyesj	446	7	,	,	,
cord-000248-zueoyesj	446	8	CXCL1	cxcl1	NN
cord-000248-zueoyesj	446	9	/	/	SYM
cord-000248-zueoyesj	446	10	chemokine	chemokine	NN
cord-000248-zueoyesj	446	11	(	(	-LRB-
cord-000248-zueoyesj	446	12	C	C	NNP
cord-000248-zueoyesj	446	13	-	-	HYPH
cord-000248-zueoyesj	446	14	X	x	NN
cord-000248-zueoyesj	446	15	-	-	HYPH
cord-000248-zueoyesj	446	16	C	c	NN
cord-000248-zueoyesj	446	17	motif	motif	NN
cord-000248-zueoyesj	446	18	)	)	-RRB-
cord-000248-zueoyesj	447	1	ligand	ligand	NNP
cord-000248-zueoyesj	447	2	1	1	CD
cord-000248-zueoyesj	447	3	(	(	-LRB-
cord-000248-zueoyesj	447	4	melanoma	melanoma	NN
cord-000248-zueoyesj	447	5	growth	growth	NN
cord-000248-zueoyesj	447	6	stimulating	stimulate	VBG
cord-000248-zueoyesj	447	7	activity	activity	NN
cord-000248-zueoyesj	447	8	,	,	,
cord-000248-zueoyesj	447	9	alpha	alpha	NN
cord-000248-zueoyesj	447	10	)	)	-RRB-
cord-000248-zueoyesj	447	11	[	[	-LRB-
cord-000248-zueoyesj	447	12	265	265	CD
cord-000248-zueoyesj	447	13	,	,	,
cord-000248-zueoyesj	447	14	266	266	CD
cord-000248-zueoyesj	447	15	,	,	,
cord-000248-zueoyesj	447	16	267	267	CD
cord-000248-zueoyesj	447	17	,	,	,
cord-000248-zueoyesj	447	18	268	268	CD
cord-000248-zueoyesj	447	19	,	,	,
cord-000248-zueoyesj	447	20	269	269	CD
cord-000248-zueoyesj	447	21	,	,	,
cord-000248-zueoyesj	447	22	270	270	CD
cord-000248-zueoyesj	447	23	,	,	,
cord-000248-zueoyesj	447	24	271	271	CD
cord-000248-zueoyesj	447	25	,	,	,
cord-000248-zueoyesj	447	26	272	272	CD
cord-000248-zueoyesj	447	27	,	,	,
cord-000248-zueoyesj	447	28	273	273	CD
cord-000248-zueoyesj	447	29	,	,	,
cord-000248-zueoyesj	447	30	274	274	CD
cord-000248-zueoyesj	447	31	,	,	,
cord-000248-zueoyesj	447	32	275	275	CD
cord-000248-zueoyesj	447	33	,	,	,
cord-000248-zueoyesj	447	34	276	276	CD
cord-000248-zueoyesj	447	35	,	,	,
cord-000248-zueoyesj	447	36	277	277	CD
cord-000248-zueoyesj	447	37	,	,	,
cord-000248-zueoyesj	447	38	278	278	CD
cord-000248-zueoyesj	447	39	,	,	,
cord-000248-zueoyesj	447	40	279	279	CD
cord-000248-zueoyesj	447	41	,	,	,
cord-000248-zueoyesj	447	42	280	280	CD
cord-000248-zueoyesj	447	43	,	,	,
cord-000248-zueoyesj	447	44	281	281	CD
cord-000248-zueoyesj	447	45	,	,	,
cord-000248-zueoyesj	447	46	282	282	CD
cord-000248-zueoyesj	447	47	,	,	,
cord-000248-zueoyesj	447	48	283	283	CD
cord-000248-zueoyesj	447	49	,	,	,
cord-000248-zueoyesj	447	50	284	284	CD
cord-000248-zueoyesj	447	51	,	,	,
cord-000248-zueoyesj	447	52	285	285	CD
cord-000248-zueoyesj	447	53	]	]	-RRB-
cord-000248-zueoyesj	447	54	(	(	-LRB-
cord-000248-zueoyesj	447	55	in	in	IN
cord-000248-zueoyesj	448	1	uveal	uveal	JJ
cord-000248-zueoyesj	448	2	melanoma	melanoma	NN
cord-000248-zueoyesj	448	3	see	see	VBP
cord-000248-zueoyesj	448	4	[	[	-LRB-
cord-000248-zueoyesj	448	5	286	286	CD
cord-000248-zueoyesj	448	6	]	]	-RRB-
cord-000248-zueoyesj	448	7	)	)	-RRB-
cord-000248-zueoyesj	448	8	,	,	.
cord-000248-zueoyesj	449	1	CXCL10	CXCL10	NNP
cord-000248-zueoyesj	449	2	[	[	-LRB-
cord-000248-zueoyesj	449	3	256	256	CD
cord-000248-zueoyesj	449	4	]	]	-RRB-
cord-000248-zueoyesj	449	5	,	,	.
cord-000248-zueoyesj	450	1	FLT1	FLT1	NNP
cord-000248-zueoyesj	450	2	/	/	SYM
cord-000248-zueoyesj	450	3	VEGFR1	VEGFR1	NNP
cord-000248-zueoyesj	450	4	[	[	-LRB-
cord-000248-zueoyesj	450	5	287	287	CD
cord-000248-zueoyesj	450	6	,	,	,
cord-000248-zueoyesj	450	7	288	288	CD
cord-000248-zueoyesj	450	8	,	,	,
cord-000248-zueoyesj	450	9	289	289	CD
cord-000248-zueoyesj	450	10	,	,	,
cord-000248-zueoyesj	450	11	290	290	CD
cord-000248-zueoyesj	450	12	,	,	,
cord-000248-zueoyesj	450	13	291	291	CD
cord-000248-zueoyesj	450	14	,	,	,
cord-000248-zueoyesj	450	15	292	292	CD
cord-000248-zueoyesj	450	16	,	,	,
cord-000248-zueoyesj	450	17	293	293	CD
cord-000248-zueoyesj	450	18	,	,	,
cord-000248-zueoyesj	450	19	294	294	CD
cord-000248-zueoyesj	450	20	,	,	,
cord-000248-zueoyesj	450	21	295	295	CD
cord-000248-zueoyesj	450	22	,	,	,
cord-000248-zueoyesj	450	23	296	296	CD
cord-000248-zueoyesj	450	24	,	,	,
cord-000248-zueoyesj	450	25	297	297	CD
cord-000248-zueoyesj	450	26	,	,	,
cord-000248-zueoyesj	450	27	298	298	CD
cord-000248-zueoyesj	450	28	,	,	,
cord-000248-zueoyesj	450	29	299	299	CD
cord-000248-zueoyesj	450	30	]	]	-RRB-
cord-000248-zueoyesj	450	31	,	,	,
cord-000248-zueoyesj	450	32	FTH1	FTH1	NNP
cord-000248-zueoyesj	450	33	/	/	SYM
cord-000248-zueoyesj	450	34	Ferritin	Ferritin	NNP
cord-000248-zueoyesj	450	35	Heavy	Heavy	NNP
cord-000248-zueoyesj	450	36	Chain	Chain	NNP
cord-000248-zueoyesj	450	37	[	[	-LRB-
cord-000248-zueoyesj	450	38	300	300	CD
cord-000248-zueoyesj	450	39	,	,	,
cord-000248-zueoyesj	450	40	301	301	CD
cord-000248-zueoyesj	450	41	,	,	,
cord-000248-zueoyesj	450	42	302	302	CD
cord-000248-zueoyesj	450	43	]	]	-RRB-
cord-000248-zueoyesj	450	44	(	(	-LRB-
cord-000248-zueoyesj	450	45	which	which	WDT
cord-000248-zueoyesj	450	46	may	may	MD
cord-000248-zueoyesj	450	47	indicate	indicate	VB
cord-000248-zueoyesj	450	48	a	a	DT
cord-000248-zueoyesj	450	49	necessary	necessary	JJ
cord-000248-zueoyesj	450	50	condition	condition	NN
cord-000248-zueoyesj	450	51	for	for	IN
cord-000248-zueoyesj	450	52	the	the	DT
cord-000248-zueoyesj	450	53	mainainance	mainainance	NN
cord-000248-zueoyesj	450	54	of	of	IN
cord-000248-zueoyesj	450	55	iron	iron	NN
cord-000248-zueoyesj	450	56	sequestration	sequestration	NN
cord-000248-zueoyesj	450	57	and	and	CC
cord-000248-zueoyesj	450	58	suppression	suppression	NN
cord-000248-zueoyesj	450	59	of	of	IN
cord-000248-zueoyesj	450	60	reactive	reactive	JJ
cord-000248-zueoyesj	450	61	oxygen	oxygen	NN
cord-000248-zueoyesj	450	62	species	species	NN
cord-000248-zueoyesj	450	63	accumulation	accumulation	NN
cord-000248-zueoyesj	450	64	[	[	-LRB-
cord-000248-zueoyesj	450	65	303	303	CD
cord-000248-zueoyesj	450	66	]	]	-RRB-
cord-000248-zueoyesj	450	67	)	)	-RRB-
cord-000248-zueoyesj	450	68	,	,	,
cord-000248-zueoyesj	450	69	FPRL1	FPRL1	NNP
cord-000248-zueoyesj	450	70	,	,	,
cord-000248-zueoyesj	450	71	LIG3	LIG3	NNP
cord-000248-zueoyesj	450	72	/	/	SYM
cord-000248-zueoyesj	450	73	DNA	DNA	NNP
cord-000248-zueoyesj	450	74	Ligase	Ligase	NNP
cord-000248-zueoyesj	450	75	3	3	CD
cord-000248-zueoyesj	450	76	[	[	-LRB-
cord-000248-zueoyesj	450	77	304	304	CD
cord-000248-zueoyesj	450	78	]	]	-RRB-
cord-000248-zueoyesj	450	79	(	(	-LRB-
cord-000248-zueoyesj	451	1	which	which	WDT
cord-000248-zueoyesj	451	2	,	,	,
cord-000248-zueoyesj	451	3	together	together	RB
cord-000248-zueoyesj	451	4	with	with	IN
cord-000248-zueoyesj	451	5	XPA	XPA	NNP
cord-000248-zueoyesj	451	6	and	and	CC
cord-000248-zueoyesj	451	7	ERCC5	ERCC5	NNP
cord-000248-zueoyesj	451	8	is	be	VBZ
cord-000248-zueoyesj	451	9	associated	associate	VBN
cord-000248-zueoyesj	451	10	to	to	IN
cord-000248-zueoyesj	451	11	DNA	dna	NN
cord-000248-zueoyesj	451	12	repair	repair	NN
cord-000248-zueoyesj	451	13	in	in	IN
cord-000248-zueoyesj	451	14	ionizing	ionize	VBG
cord-000248-zueoyesj	451	15	radition	radition	NN
cord-000248-zueoyesj	451	16	studies	study	NNS
cord-000248-zueoyesj	451	17	[	[	-LRB-
cord-000248-zueoyesj	451	18	305	305	CD
cord-000248-zueoyesj	451	19	]	]	-RRB-
cord-000248-zueoyesj	451	20	)	)	-RRB-
cord-000248-zueoyesj	451	21	,	,	,
cord-000248-zueoyesj	451	22	MCMDC1	mcmdc1	NN
cord-000248-zueoyesj	451	23	,	,	,
cord-000248-zueoyesj	451	24	PSEN2	psen2	FW
cord-000248-zueoyesj	451	25	,	,	,
cord-000248-zueoyesj	452	1	NRP2	NRP2	NNP
cord-000248-zueoyesj	452	2	/	/	SYM
cord-000248-zueoyesj	452	3	Neuropilin	Neuropilin	NNP
cord-000248-zueoyesj	452	4	2	2	CD
cord-000248-zueoyesj	452	5	/	/	SYM
cord-000248-zueoyesj	452	6	Vascular	vascular	JJ
cord-000248-zueoyesj	452	7	endothelial	endothelial	JJ
cord-000248-zueoyesj	452	8	cell	cell	NN
cord-000248-zueoyesj	452	9	growth	growth	NN
cord-000248-zueoyesj	452	10	factor	factor	NN
cord-000248-zueoyesj	452	11	165	165	CD
cord-000248-zueoyesj	452	12	receptor	receptor	NN
cord-000248-zueoyesj	452	13	2	2	CD
cord-000248-zueoyesj	452	14	[	[	-LRB-
cord-000248-zueoyesj	452	15	306	306	CD
cord-000248-zueoyesj	452	16	,	,	,
cord-000248-zueoyesj	452	17	307	307	CD
cord-000248-zueoyesj	452	18	,	,	,
cord-000248-zueoyesj	452	19	308	308	CD
cord-000248-zueoyesj	452	20	]	]	-RRB-
cord-000248-zueoyesj	452	21	,	,	,
cord-000248-zueoyesj	452	22	SEMA6A	SEMA6A	NNP
cord-000248-zueoyesj	452	23	(	(	-LRB-
cord-000248-zueoyesj	452	24	a	a	DT
cord-000248-zueoyesj	452	25	member	member	NN
cord-000248-zueoyesj	452	26	of	of	IN
cord-000248-zueoyesj	452	27	the	the	DT
cord-000248-zueoyesj	452	28	Semaphorin	Semaphorin	NNP
cord-000248-zueoyesj	452	29	family	family	NN
cord-000248-zueoyesj	452	30	,	,	,
cord-000248-zueoyesj	452	31	of	of	IN
cord-000248-zueoyesj	452	32	increasing	increase	VBG
cord-000248-zueoyesj	452	33	importance	importance	NN
cord-000248-zueoyesj	452	34	in	in	IN
cord-000248-zueoyesj	452	35	cancer	cancer	NN
cord-000248-zueoyesj	452	36	research	research	NN
cord-000248-zueoyesj	452	37	[	[	-LRB-
cord-000248-zueoyesj	452	38	309	309	CD
cord-000248-zueoyesj	452	39	,	,	,
cord-000248-zueoyesj	452	40	310	310	CD
cord-000248-zueoyesj	452	41	,	,	,
cord-000248-zueoyesj	452	42	311	311	CD
cord-000248-zueoyesj	452	43	]	]	-RRB-
cord-000248-zueoyesj	452	44	and	and	CC
cord-000248-zueoyesj	453	1	in	in	IN
cord-000248-zueoyesj	453	2	particular	particular	JJ
cord-000248-zueoyesj	453	3	due	due	IN
cord-000248-zueoyesj	453	4	to	to	IN
cord-000248-zueoyesj	453	5	its	-PRON-	PRP$
cord-000248-zueoyesj	453	6	observed	observed	JJ
cord-000248-zueoyesj	453	7	upregulation	upregulation	NN
cord-000248-zueoyesj	453	8	in	in	IN
cord-000248-zueoyesj	453	9	undifferentiated	undifferentiated	JJ
cord-000248-zueoyesj	453	10	embryonic	embryonic	JJ
cord-000248-zueoyesj	453	11	stem	stem	NN
cord-000248-zueoyesj	453	12	cells	cell	NNS
cord-000248-zueoyesj	453	13	[	[	-LRB-
cord-000248-zueoyesj	453	14	312	312	CD
cord-000248-zueoyesj	453	15	]	]	-RRB-
cord-000248-zueoyesj	453	16	)	)	-RRB-
cord-000248-zueoyesj	453	17	,	,	,
cord-000248-zueoyesj	453	18	SLAMF1	slamf1	NN
cord-000248-zueoyesj	453	19	/	/	SYM
cord-000248-zueoyesj	453	20	CD150	cd150	NN
cord-000248-zueoyesj	453	21	(	(	-LRB-
cord-000248-zueoyesj	453	22	a	a	DT
cord-000248-zueoyesj	453	23	marker	marker	NN
cord-000248-zueoyesj	453	24	associated	associate	VBN
cord-000248-zueoyesj	453	25	with	with	IN
cord-000248-zueoyesj	453	26	hematopoietic	hematopoietic	JJ
cord-000248-zueoyesj	453	27	stem	stem	NN
cord-000248-zueoyesj	453	28	cells	cell	NNS
cord-000248-zueoyesj	453	29	[	[	-LRB-
cord-000248-zueoyesj	453	30	313	313	CD
cord-000248-zueoyesj	453	31	]	]	-RRB-
cord-000248-zueoyesj	453	32	)	)	-RRB-
cord-000248-zueoyesj	453	33	,	,	,
cord-000248-zueoyesj	453	34	SPP1	SPP1	NNP
cord-000248-zueoyesj	453	35	/	/	SYM
cord-000248-zueoyesj	453	36	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	453	37	(	(	-LRB-
cord-000248-zueoyesj	453	38	which	which	WDT
cord-000248-zueoyesj	453	39	,	,	,
cord-000248-zueoyesj	453	40	together	together	RB
cord-000248-zueoyesj	453	41	with	with	IN
cord-000248-zueoyesj	453	42	ARPC2	arpc2	NN
cord-000248-zueoyesj	453	43	,	,	,
cord-000248-zueoyesj	453	44	is	be	VBZ
cord-000248-zueoyesj	453	45	also	also	RB
cord-000248-zueoyesj	453	46	in	in	IN
cord-000248-zueoyesj	453	47	the	the	DT
cord-000248-zueoyesj	453	48	novel	novel	JJ
cord-000248-zueoyesj	453	49	5-biomarker	5-biomarker	CD
cord-000248-zueoyesj	453	50	panel	panel	NN
cord-000248-zueoyesj	453	51	of	of	IN
cord-000248-zueoyesj	453	52	Kashani	Kashani	NNP
cord-000248-zueoyesj	453	53	-	-	HYPH
cord-000248-zueoyesj	453	54	Sabet	Sabet	NNP
cord-000248-zueoyesj	453	55	et	et	NNP
cord-000248-zueoyesj	453	56	al	al	NNP
cord-000248-zueoyesj	453	57	.	.	.
cord-000248-zueoyesj	454	1	[	[	-LRB-
cord-000248-zueoyesj	454	2	253	253	CD
cord-000248-zueoyesj	454	3	]	]	-RRB-
cord-000248-zueoyesj	454	4	)	)	-RRB-
cord-000248-zueoyesj	455	1	[	[	-LRB-
cord-000248-zueoyesj	455	2	206	206	CD
cord-000248-zueoyesj	455	3	,	,	,
cord-000248-zueoyesj	455	4	207	207	CD
cord-000248-zueoyesj	455	5	,	,	,
cord-000248-zueoyesj	455	6	208	208	CD
cord-000248-zueoyesj	455	7	,	,	,
cord-000248-zueoyesj	455	8	209	209	CD
cord-000248-zueoyesj	455	9	,	,	,
cord-000248-zueoyesj	455	10	210	210	CD
cord-000248-zueoyesj	455	11	,	,	,
cord-000248-zueoyesj	455	12	211	211	CD
cord-000248-zueoyesj	455	13	,	,	,
cord-000248-zueoyesj	455	14	212	212	CD
cord-000248-zueoyesj	455	15	]	]	-RRB-
cord-000248-zueoyesj	456	1	[	[	-LRB-
cord-000248-zueoyesj	456	2	206,207,208,209,210	206,207,208,209,210	CD
cord-000248-zueoyesj	456	3	,	,	,
cord-000248-zueoyesj	456	4	211,212,214,215,216,217,218,219,220,221,222,226,314,315,316,-317,318,319,320,321,322,323,324,325,326,327,328,329	211,212,214,215,216,217,218,219,220,221,222,226,314,315,316,-317,318,319,320,321,322,323,324,325,326,327,328,329	CD
cord-000248-zueoyesj	456	5	]	]	-RRB-
cord-000248-zueoyesj	457	1	,	,	,
cord-000248-zueoyesj	457	2	STK6	STK6	NNP
cord-000248-zueoyesj	457	3	[	[	-LRB-
cord-000248-zueoyesj	457	4	230	230	CD
cord-000248-zueoyesj	457	5	,	,	,
cord-000248-zueoyesj	457	6	330	330	CD
cord-000248-zueoyesj	457	7	]	]	-RRB-
cord-000248-zueoyesj	457	8	,	,	,
cord-000248-zueoyesj	457	9	and	and	CC
cord-000248-zueoyesj	457	10	WARS	war	NNS
cord-000248-zueoyesj	457	11	/	/	SYM
cord-000248-zueoyesj	457	12	Tryptophanyl	Tryptophanyl	NNP
cord-000248-zueoyesj	457	13	-	-	HYPH
cord-000248-zueoyesj	457	14	tRNA	trna	NN
cord-000248-zueoyesj	457	15	synthetise	synthetise	NN
cord-000248-zueoyesj	457	16	[	[	-LRB-
cord-000248-zueoyesj	457	17	331	331	CD
cord-000248-zueoyesj	457	18	]	]	-RRB-
cord-000248-zueoyesj	457	19	.	.	.
cord-000248-zueoyesj	458	1	Figure	figure	NN
cord-000248-zueoyesj	458	2	11	11	CD
cord-000248-zueoyesj	458	3	shows	show	VBZ
cord-000248-zueoyesj	458	4	a	a	DT
cord-000248-zueoyesj	458	5	heat	heat	NN
cord-000248-zueoyesj	458	6	map	map	NN
cord-000248-zueoyesj	458	7	of	of	IN
cord-000248-zueoyesj	458	8	discussed	discuss	VBN
cord-000248-zueoyesj	458	9	gene	gene	NN
cord-000248-zueoyesj	458	10	probes	probe	NNS
cord-000248-zueoyesj	458	11	annotated	annotate	VBN
cord-000248-zueoyesj	458	12	with	with	IN
cord-000248-zueoyesj	458	13	functions	function	NNS
cord-000248-zueoyesj	458	14	on	on	IN
cord-000248-zueoyesj	458	15	cell	cell	NN
cord-000248-zueoyesj	458	16	proliferation	proliferation	NN
cord-000248-zueoyesj	458	17	.	.	.
cord-000248-zueoyesj	459	1	The	the	DT
cord-000248-zueoyesj	459	2	references	reference	NNS
cord-000248-zueoyesj	459	3	provided	provide	VBN
cord-000248-zueoyesj	459	4	next	next	RB
cord-000248-zueoyesj	459	5	to	to	IN
cord-000248-zueoyesj	459	6	each	each	DT
cord-000248-zueoyesj	459	7	gene	gene	NN
cord-000248-zueoyesj	459	8	help	help	NN
cord-000248-zueoyesj	459	9	to	to	IN
cord-000248-zueoyesj	459	10	related	relate	VBN
cord-000248-zueoyesj	459	11	these	these	DT
cord-000248-zueoyesj	459	12	upregulated	upregulate	VBN
cord-000248-zueoyesj	459	13	genes	gene	NNS
cord-000248-zueoyesj	459	14	in	in	IN
cord-000248-zueoyesj	459	15	the	the	DT
cord-000248-zueoyesj	459	16	context	context	NN
cord-000248-zueoyesj	459	17	of	of	IN
cord-000248-zueoyesj	459	18	current	current	JJ
cord-000248-zueoyesj	459	19	research	research	NN
cord-000248-zueoyesj	459	20	in	in	IN
cord-000248-zueoyesj	459	21	melanoma	melanoma	NN
cord-000248-zueoyesj	459	22	or	or	CC
cord-000248-zueoyesj	459	23	with	with	IN
cord-000248-zueoyesj	459	24	the	the	DT
cord-000248-zueoyesj	459	25	M	M	NNP
cord-000248-zueoyesj	459	26	phase	phase	NN
cord-000248-zueoyesj	459	27	of	of	IN
cord-000248-zueoyesj	459	28	mitotic	mitotic	JJ
cord-000248-zueoyesj	459	29	cell	cell	NN
cord-000248-zueoyesj	459	30	cycle	cycle	NN
cord-000248-zueoyesj	459	31	,	,	,
cord-000248-zueoyesj	459	32	showing	show	VBG
cord-000248-zueoyesj	459	33	a	a	DT
cord-000248-zueoyesj	459	34	high	high	JJ
cord-000248-zueoyesj	459	35	degree	degree	NN
cord-000248-zueoyesj	459	36	of	of	IN
cord-000248-zueoyesj	459	37	correlation	correlation	NN
cord-000248-zueoyesj	459	38	between	between	IN
cord-000248-zueoyesj	459	39	our	-PRON-	PRP$
cord-000248-zueoyesj	459	40	results	result	NNS
cord-000248-zueoyesj	459	41	and	and	CC
cord-000248-zueoyesj	459	42	with	with	IN
cord-000248-zueoyesj	459	43	published	publish	VBN
cord-000248-zueoyesj	459	44	literature	literature	NN
cord-000248-zueoyesj	459	45	.	.	.
cord-000248-zueoyesj	460	1	Another	another	DT
cord-000248-zueoyesj	460	2	microarray	microarray	NN
cord-000248-zueoyesj	460	3	dataset	dataset	NN
cord-000248-zueoyesj	460	4	we	-PRON-	PRP
cord-000248-zueoyesj	460	5	have	have	VBP
cord-000248-zueoyesj	460	6	selected	select	VBN
cord-000248-zueoyesj	460	7	to	to	TO
cord-000248-zueoyesj	460	8	evaluate	evaluate	VB
cord-000248-zueoyesj	460	9	for	for	IN
cord-000248-zueoyesj	460	10	the	the	DT
cord-000248-zueoyesj	460	11	relevance	relevance	NN
cord-000248-zueoyesj	460	12	of	of	IN
cord-000248-zueoyesj	460	13	transitions	transition	NNS
cord-000248-zueoyesj	460	14	of	of	IN
cord-000248-zueoyesj	460	15	Normalized	Normalized	NNP
cord-000248-zueoyesj	460	16	Shannon	Shannon	NNP
cord-000248-zueoyesj	460	17	Entropy	Entropy	NNP
cord-000248-zueoyesj	460	18	and	and	CC
cord-000248-zueoyesj	460	19	Statistical	Statistical	NNP
cord-000248-zueoyesj	460	20	Complexity	Complexity	NNP
cord-000248-zueoyesj	460	21	was	be	VBD
cord-000248-zueoyesj	460	22	contributed	contribute	VBN
cord-000248-zueoyesj	460	23	by	by	IN
cord-000248-zueoyesj	460	24	True	True	NNP
cord-000248-zueoyesj	460	25	et	et	NNP
cord-000248-zueoyesj	460	26	al	al	NNP
cord-000248-zueoyesj	460	27	.	.	.
cord-000248-zueoyesj	461	1	[	[	-LRB-
cord-000248-zueoyesj	461	2	332	332	CD
cord-000248-zueoyesj	461	3	]	]	-RRB-
cord-000248-zueoyesj	461	4	in	in	IN
cord-000248-zueoyesj	461	5	2006	2006	CD
cord-000248-zueoyesj	461	6	.	.	.
cord-000248-zueoyesj	462	1	The	the	DT
cord-000248-zueoyesj	462	2	original	original	JJ
cord-000248-zueoyesj	462	3	goal	goal	NN
cord-000248-zueoyesj	462	4	of	of	IN
cord-000248-zueoyesj	462	5	True	True	NNP
cord-000248-zueoyesj	462	6	et	et	NNP
cord-000248-zueoyesj	462	7	al	al	NNP
cord-000248-zueoyesj	462	8	.	.	NNP
cord-000248-zueoyesj	462	9	was	be	VBD
cord-000248-zueoyesj	462	10	to	to	TO
cord-000248-zueoyesj	462	11	identify	identify	VB
cord-000248-zueoyesj	462	12	a	a	DT
cord-000248-zueoyesj	462	13	molecular	molecular	JJ
cord-000248-zueoyesj	462	14	correlate	correlate	NN
cord-000248-zueoyesj	462	15	for	for	IN
cord-000248-zueoyesj	462	16	Gleason	Gleason	NNP
cord-000248-zueoyesj	462	17	patterns	pattern	NNS
cord-000248-zueoyesj	462	18	3	3	CD
cord-000248-zueoyesj	462	19	and	and	CC
cord-000248-zueoyesj	462	20	,	,	,
cord-000248-zueoyesj	462	21	if	if	IN
cord-000248-zueoyesj	462	22	possible	possible	JJ
cord-000248-zueoyesj	462	23	,	,	,
cord-000248-zueoyesj	462	24	the	the	DT
cord-000248-zueoyesj	462	25	clinically	clinically	RB
cord-000248-zueoyesj	462	26	most	most	RBS
cord-000248-zueoyesj	462	27	worrisome	worrisome	JJ
cord-000248-zueoyesj	462	28	patterns	pattern	NNS
cord-000248-zueoyesj	462	29	4	4	CD
cord-000248-zueoyesj	462	30	and	and	CC
cord-000248-zueoyesj	462	31	5	5	CD
cord-000248-zueoyesj	462	32	.	.	.
cord-000248-zueoyesj	463	1	They	-PRON-	PRP
cord-000248-zueoyesj	463	2	partially	partially	RB
cord-000248-zueoyesj	463	3	succeeded	succeed	VBN
cord-000248-zueoyesj	463	4	by	by	IN
cord-000248-zueoyesj	463	5	linking	link	VBG
cord-000248-zueoyesj	463	6	the	the	DT
cord-000248-zueoyesj	463	7	expression	expression	NN
cord-000248-zueoyesj	463	8	of	of	IN
cord-000248-zueoyesj	463	9	only	only	RB
cord-000248-zueoyesj	463	10	86	86	CD
cord-000248-zueoyesj	463	11	genes	gene	NNS
cord-000248-zueoyesj	463	12	with	with	IN
cord-000248-zueoyesj	463	13	Gleason	Gleason	NNP
cord-000248-zueoyesj	463	14	pattern	pattern	NN
cord-000248-zueoyesj	463	15	3	3	CD
cord-000248-zueoyesj	463	16	[	[	-LRB-
cord-000248-zueoyesj	463	17	332	332	CD
cord-000248-zueoyesj	463	18	]	]	-RRB-
cord-000248-zueoyesj	463	19	using	use	VBG
cord-000248-zueoyesj	463	20	a	a	DT
cord-000248-zueoyesj	463	21	standard	standard	JJ
cord-000248-zueoyesj	463	22	statistical	statistical	JJ
cord-000248-zueoyesj	463	23	analysis	analysis	NN
cord-000248-zueoyesj	463	24	.	.	.
cord-000248-zueoyesj	464	1	In	in	IN
cord-000248-zueoyesj	464	2	this	this	DT
cord-000248-zueoyesj	464	3	study	study	NN
cord-000248-zueoyesj	464	4	,	,	,
cord-000248-zueoyesj	464	5	we	-PRON-	PRP
cord-000248-zueoyesj	464	6	eliminated	eliminate	VBD
cord-000248-zueoyesj	464	7	sample	sample	NN
cord-000248-zueoyesj	464	8	02	02	CD
cord-000248-zueoyesj	464	9	-	-	SYM
cord-000248-zueoyesj	464	10	209C	209c	CD
cord-000248-zueoyesj	464	11	since	since	IN
cord-000248-zueoyesj	464	12	data	datum	NNS
cord-000248-zueoyesj	464	13	was	be	VBD
cord-000248-zueoyesj	464	14	acquired	acquire	VBN
cord-000248-zueoyesj	464	15	using	use	VBG
cord-000248-zueoyesj	464	16	a	a	DT
cord-000248-zueoyesj	464	17	different	different	JJ
cord-000248-zueoyesj	464	18	platform	platform	NN
cord-000248-zueoyesj	464	19	and	and	CC
cord-000248-zueoyesj	464	20	would	would	MD
cord-000248-zueoyesj	464	21	not	not	RB
cord-000248-zueoyesj	464	22	be	be	VB
cord-000248-zueoyesj	464	23	useful	useful	JJ
cord-000248-zueoyesj	464	24	for	for	IN
cord-000248-zueoyesj	464	25	our	-PRON-	PRP$
cord-000248-zueoyesj	464	26	analysis	analysis	NN
cord-000248-zueoyesj	464	27	.	.	.
cord-000248-zueoyesj	465	1	The	the	DT
cord-000248-zueoyesj	465	2	remaining	remain	VBG
cord-000248-zueoyesj	465	3	thirty	thirty	CD
cord-000248-zueoyesj	465	4	one	one	CD
cord-000248-zueoyesj	465	5	(	(	-LRB-
cord-000248-zueoyesj	465	6	31	31	CD
cord-000248-zueoyesj	465	7	)	)	-RRB-
cord-000248-zueoyesj	465	8	samples	sample	NNS
cord-000248-zueoyesj	465	9	were	be	VBD
cord-000248-zueoyesj	465	10	assayed	assay	VBN
cord-000248-zueoyesj	465	11	with	with	IN
cord-000248-zueoyesj	465	12	the	the	DT
cord-000248-zueoyesj	465	13	GPL3834	GPL3834	NNPS
cord-000248-zueoyesj	465	14	(	(	-LRB-
cord-000248-zueoyesj	465	15	FHCRC	FHCRC	NNP
cord-000248-zueoyesj	465	16	Human	Human	NNP
cord-000248-zueoyesj	465	17	Prostate	Prostate	NNP
cord-000248-zueoyesj	465	18	PEDB	PEDB	NNP
cord-000248-zueoyesj	465	19	cDNA	cdna	NN
cord-000248-zueoyesj	465	20	Array	Array	NNP
cord-000248-zueoyesj	465	21	v4	v4	NNP
cord-000248-zueoyesj	465	22	)	)	-RRB-
cord-000248-zueoyesj	465	23	platform	platform	NN
cord-000248-zueoyesj	465	24	using	use	VBG
cord-000248-zueoyesj	465	25	15,488	15,488	CD
cord-000248-zueoyesj	465	26	probes	probe	NNS
cord-000248-zueoyesj	465	27	.	.	.
cord-000248-zueoyesj	466	1	We	-PRON-	PRP
cord-000248-zueoyesj	466	2	also	also	RB
cord-000248-zueoyesj	466	3	eliminated	eliminate	VBD
cord-000248-zueoyesj	466	4	all	all	PDT
cord-000248-zueoyesj	466	5	the	the	DT
cord-000248-zueoyesj	466	6	probes	probe	NNS
cord-000248-zueoyesj	466	7	with	with	IN
cord-000248-zueoyesj	466	8	missing	miss	VBG
cord-000248-zueoyesj	466	9	values	value	NNS
cord-000248-zueoyesj	466	10	,	,	,
cord-000248-zueoyesj	466	11	remaining	remain	VBG
cord-000248-zueoyesj	466	12	13,188	13,188	CD
cord-000248-zueoyesj	466	13	probes	probe	NNS
cord-000248-zueoyesj	466	14	.	.	.
cord-000248-zueoyesj	467	1	We	-PRON-	PRP
cord-000248-zueoyesj	467	2	have	have	VBP
cord-000248-zueoyesj	467	3	first	first	RB
cord-000248-zueoyesj	467	4	plotted	plot	VBN
cord-000248-zueoyesj	467	5	the	the	DT
cord-000248-zueoyesj	467	6	samples	sample	NNS
cord-000248-zueoyesj	467	7	on	on	IN
cord-000248-zueoyesj	467	8	the	the	DT
cord-000248-zueoyesj	467	9	(	(	-LRB-
cord-000248-zueoyesj	467	10	Normalized	normalize	VBN
cord-000248-zueoyesj	467	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	467	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	467	13	,	,	,
cord-000248-zueoyesj	467	14	MPR	MPR	NNP
cord-000248-zueoyesj	467	15	-	-	HYPH
cord-000248-zueoyesj	467	16	Statistical	Statistical	NNP
cord-000248-zueoyesj	467	17	Complexity	Complexity	NNP
cord-000248-zueoyesj	467	18	)	)	-RRB-
cord-000248-zueoyesj	467	19	plane	plane	NN
cord-000248-zueoyesj	467	20	(	(	-LRB-
cord-000248-zueoyesj	467	21	Figure	figure	NN
cord-000248-zueoyesj	467	22	12	12	CD
cord-000248-zueoyesj	467	23	)	)	-RRB-
cord-000248-zueoyesj	467	24	.	.	.
cord-000248-zueoyesj	468	1	It	-PRON-	PRP
cord-000248-zueoyesj	468	2	was	be	VBD
cord-000248-zueoyesj	468	3	interesting	interesting	JJ
cord-000248-zueoyesj	468	4	to	to	TO
cord-000248-zueoyesj	468	5	observe	observe	VB
cord-000248-zueoyesj	468	6	that	that	IN
cord-000248-zueoyesj	468	7	there	there	EX
cord-000248-zueoyesj	468	8	exists	exist	VBZ
cord-000248-zueoyesj	468	9	a	a	DT
cord-000248-zueoyesj	468	10	high	high	JJ
cord-000248-zueoyesj	468	11	correlation	correlation	NN
cord-000248-zueoyesj	468	12	between	between	IN
cord-000248-zueoyesj	468	13	the	the	DT
cord-000248-zueoyesj	468	14	two	two	CD
cord-000248-zueoyesj	468	15	measures	measure	NNS
cord-000248-zueoyesj	468	16	.	.	.
cord-000248-zueoyesj	469	1	Samples	sample	NNS
cord-000248-zueoyesj	469	2	that	that	WDT
cord-000248-zueoyesj	469	3	are	be	VBP
cord-000248-zueoyesj	469	4	entirely	entirely	RB
cord-000248-zueoyesj	469	5	composed	compose	VBN
cord-000248-zueoyesj	469	6	of	of	IN
cord-000248-zueoyesj	469	7	Gleason	Gleason	NNP
cord-000248-zueoyesj	469	8	pattern	pattern	NN
cord-000248-zueoyesj	469	9	3	3	CD
cord-000248-zueoyesj	469	10	tend	tend	VBP
cord-000248-zueoyesj	469	11	to	to	TO
cord-000248-zueoyesj	469	12	have	have	VB
cord-000248-zueoyesj	469	13	a	a	DT
cord-000248-zueoyesj	469	14	greater	great	JJR
cord-000248-zueoyesj	469	15	value	value	NN
cord-000248-zueoyesj	469	16	of	of	IN
cord-000248-zueoyesj	469	17	Normalized	Normalized	NNP
cord-000248-zueoyesj	469	18	Shannon	Shannon	NNP
cord-000248-zueoyesj	469	19	Entropy	Entropy	NNP
cord-000248-zueoyesj	469	20	than	than	IN
cord-000248-zueoyesj	469	21	0.985	0.985	CD
cord-000248-zueoyesj	469	22	.	.	.
cord-000248-zueoyesj	470	1	We	-PRON-	PRP
cord-000248-zueoyesj	470	2	can	can	MD
cord-000248-zueoyesj	470	3	also	also	RB
cord-000248-zueoyesj	470	4	identify	identify	VB
cord-000248-zueoyesj	470	5	a	a	DT
cord-000248-zueoyesj	470	6	cluster	cluster	NN
cord-000248-zueoyesj	470	7	of	of	IN
cord-000248-zueoyesj	470	8	samples	sample	NNS
cord-000248-zueoyesj	470	9	that	that	WDT
cord-000248-zueoyesj	470	10	present	present	VBP
cord-000248-zueoyesj	470	11	Gleason	Gleason	NNP
cord-000248-zueoyesj	470	12	patterns	pattern	NNS
cord-000248-zueoyesj	470	13	which	which	WDT
cord-000248-zueoyesj	470	14	are	be	VBP
cord-000248-zueoyesj	470	15	either	either	DT
cord-000248-zueoyesj	470	16	4	4	CD
cord-000248-zueoyesj	470	17	or	or	CC
cord-000248-zueoyesj	470	18	5	5	CD
cord-000248-zueoyesj	470	19	.	.	.
cord-000248-zueoyesj	471	1	Note	note	VB
cord-000248-zueoyesj	471	2	that	that	IN
cord-000248-zueoyesj	471	3	there	there	EX
cord-000248-zueoyesj	471	4	seems	seem	VBZ
cord-000248-zueoyesj	471	5	to	to	TO
cord-000248-zueoyesj	471	6	be	be	VB
cord-000248-zueoyesj	471	7	two	two	CD
cord-000248-zueoyesj	471	8	outliers	outlier	NNS
cord-000248-zueoyesj	471	9	(	(	-LRB-
cord-000248-zueoyesj	471	10	02_003E	02_003e	CD
cord-000248-zueoyesj	471	11	and	and	CC
cord-000248-zueoyesj	471	12	03_063	03_063	LS
cord-000248-zueoyesj	471	13	)	)	-RRB-
cord-000248-zueoyesj	471	14	to	to	IN
cord-000248-zueoyesj	471	15	the	the	DT
cord-000248-zueoyesj	471	16	generic	generic	JJ
cord-000248-zueoyesj	471	17	trend	trend	NN
cord-000248-zueoyesj	471	18	of	of	IN
cord-000248-zueoyesj	471	19	the	the	DT
cord-000248-zueoyesj	471	20	other	other	JJ
cord-000248-zueoyesj	471	21	29	29	CD
cord-000248-zueoyesj	471	22	samples	sample	NNS
cord-000248-zueoyesj	471	23	.	.	.
cord-000248-zueoyesj	472	1	The	the	DT
cord-000248-zueoyesj	472	2	two	two	CD
cord-000248-zueoyesj	472	3	outliers	outlier	NNS
cord-000248-zueoyesj	472	4	are	be	VBP
cord-000248-zueoyesj	472	5	samples	sample	NNS
cord-000248-zueoyesj	472	6	that	that	WDT
cord-000248-zueoyesj	472	7	correspond	correspond	VBP
cord-000248-zueoyesj	472	8	to	to	IN
cord-000248-zueoyesj	472	9	samples	sample	NNS
cord-000248-zueoyesj	472	10	labelled	label	VBN
cord-000248-zueoyesj	472	11	as	as	IN
cord-000248-zueoyesj	472	12	having	have	VBG
cord-000248-zueoyesj	472	13	Gleason	Gleason	NNP
cord-000248-zueoyesj	472	14	3	3	CD
cord-000248-zueoyesj	472	15	patterns	pattern	NNS
cord-000248-zueoyesj	472	16	and	and	CC
cord-000248-zueoyesj	472	17	both	both	DT
cord-000248-zueoyesj	472	18	have	have	VBP
cord-000248-zueoyesj	472	19	unusually	unusually	RB
cord-000248-zueoyesj	472	20	low	low	JJ
cord-000248-zueoyesj	472	21	values	value	NNS
cord-000248-zueoyesj	472	22	of	of	IN
cord-000248-zueoyesj	472	23	Normalized	Normalized	NNP
cord-000248-zueoyesj	472	24	Shannon	Shannon	NNP
cord-000248-zueoyesj	472	25	Entropy	Entropy	NNP
cord-000248-zueoyesj	472	26	that	that	WDT
cord-000248-zueoyesj	472	27	are	be	VBP
cord-000248-zueoyesj	472	28	well	well	RB
cord-000248-zueoyesj	472	29	below	below	IN
cord-000248-zueoyesj	472	30	the	the	DT
cord-000248-zueoyesj	472	31	values	value	NNS
cord-000248-zueoyesj	472	32	of	of	IN
cord-000248-zueoyesj	472	33	the	the	DT
cord-000248-zueoyesj	472	34	rest	rest	NN
cord-000248-zueoyesj	472	35	of	of	IN
cord-000248-zueoyesj	472	36	the	the	DT
cord-000248-zueoyesj	472	37	group	group	NN
cord-000248-zueoyesj	472	38	.	.	.
cord-000248-zueoyesj	473	1	This	this	DT
cord-000248-zueoyesj	473	2	raised	raise	VBD
cord-000248-zueoyesj	473	3	a	a	DT
cord-000248-zueoyesj	473	4	suspicion	suspicion	NN
cord-000248-zueoyesj	473	5	about	about	IN
cord-000248-zueoyesj	473	6	the	the	DT
cord-000248-zueoyesj	473	7	true	true	JJ
cord-000248-zueoyesj	473	8	nature	nature	NN
cord-000248-zueoyesj	473	9	of	of	IN
cord-000248-zueoyesj	473	10	this	this	DT
cord-000248-zueoyesj	473	11	phenomenon	phenomenon	NN
cord-000248-zueoyesj	473	12	.	.	.
cord-000248-zueoyesj	474	1	If	if	IN
cord-000248-zueoyesj	474	2	the	the	DT
cord-000248-zueoyesj	474	3	labelling	labelling	NN
cord-000248-zueoyesj	474	4	is	be	VBZ
cord-000248-zueoyesj	474	5	correct	correct	JJ
cord-000248-zueoyesj	474	6	,	,	,
cord-000248-zueoyesj	474	7	this	this	DT
cord-000248-zueoyesj	474	8	may	may	MD
cord-000248-zueoyesj	474	9	indicate	indicate	VB
cord-000248-zueoyesj	474	10	a	a	DT
cord-000248-zueoyesj	474	11	subsampled	subsampled	JJ
cord-000248-zueoyesj	474	12	group	group	NN
cord-000248-zueoyesj	474	13	of	of	IN
cord-000248-zueoyesj	474	14	prostate	prostate	NN
cord-000248-zueoyesj	474	15	cancer	cancer	NN
cord-000248-zueoyesj	474	16	that	that	WDT
cord-000248-zueoyesj	474	17	has	have	VBZ
cord-000248-zueoyesj	474	18	Gleason	Gleason	NNP
cord-000248-zueoyesj	474	19	3	3	CD
cord-000248-zueoyesj	474	20	pattern	pattern	NN
cord-000248-zueoyesj	474	21	characteristics	characteristic	NNS
cord-000248-zueoyesj	474	22	but	but	CC
cord-000248-zueoyesj	474	23	very	very	RB
cord-000248-zueoyesj	474	24	low	low	JJ
cord-000248-zueoyesj	474	25	entropy	entropy	NN
cord-000248-zueoyesj	474	26	.	.	.
cord-000248-zueoyesj	475	1	Alternatively	alternatively	RB
cord-000248-zueoyesj	475	2	,	,	,
cord-000248-zueoyesj	475	3	it	-PRON-	PRP
cord-000248-zueoyesj	475	4	may	may	MD
cord-000248-zueoyesj	475	5	indicate	indicate	VB
cord-000248-zueoyesj	475	6	an	an	DT
cord-000248-zueoyesj	475	7	experimental	experimental	JJ
cord-000248-zueoyesj	475	8	bias	bias	NN
cord-000248-zueoyesj	475	9	for	for	IN
cord-000248-zueoyesj	475	10	reasons	reason	NNS
cord-000248-zueoyesj	475	11	we	-PRON-	PRP
cord-000248-zueoyesj	475	12	can	can	MD
cord-000248-zueoyesj	475	13	not	not	RB
cord-000248-zueoyesj	475	14	explain	explain	VB
cord-000248-zueoyesj	475	15	with	with	IN
cord-000248-zueoyesj	475	16	the	the	DT
cord-000248-zueoyesj	475	17	available	available	JJ
cord-000248-zueoyesj	475	18	clinical	clinical	JJ
cord-000248-zueoyesj	475	19	information	information	NN
cord-000248-zueoyesj	475	20	.	.	.
cord-000248-zueoyesj	476	1	In	in	IN
cord-000248-zueoyesj	476	2	order	order	NN
cord-000248-zueoyesj	476	3	to	to	TO
cord-000248-zueoyesj	476	4	clarify	clarify	VB
cord-000248-zueoyesj	476	5	the	the	DT
cord-000248-zueoyesj	476	6	situation	situation	NN
cord-000248-zueoyesj	476	7	,	,	,
cord-000248-zueoyesj	476	8	and	and	CC
cord-000248-zueoyesj	476	9	see	see	VB
cord-000248-zueoyesj	476	10	if	if	IN
cord-000248-zueoyesj	476	11	we	-PRON-	PRP
cord-000248-zueoyesj	476	12	can	can	MD
cord-000248-zueoyesj	476	13	declare	declare	VB
cord-000248-zueoyesj	476	14	these	these	DT
cord-000248-zueoyesj	476	15	two	two	CD
cord-000248-zueoyesj	476	16	samples	sample	NNS
cord-000248-zueoyesj	476	17	as	as	IN
cord-000248-zueoyesj	476	18	outliers	outlier	NNS
cord-000248-zueoyesj	476	19	of	of	IN
cord-000248-zueoyesj	476	20	the	the	DT
cord-000248-zueoyesj	476	21	other	other	JJ
cord-000248-zueoyesj	476	22	group	group	NN
cord-000248-zueoyesj	476	23	,	,	,
cord-000248-zueoyesj	476	24	we	-PRON-	PRP
cord-000248-zueoyesj	476	25	performed	perform	VBD
cord-000248-zueoyesj	476	26	another	another	DT
cord-000248-zueoyesj	476	27	experiment	experiment	NN
cord-000248-zueoyesj	476	28	.	.	.
cord-000248-zueoyesj	477	1	We	-PRON-	PRP
cord-000248-zueoyesj	477	2	have	have	VBP
cord-000248-zueoyesj	477	3	now	now	RB
cord-000248-zueoyesj	477	4	computed	compute	VBN
cord-000248-zueoyesj	477	5	two	two	CD
cord-000248-zueoyesj	477	6	modified	modify	VBN
cord-000248-zueoyesj	477	7	complexities	complexity	NNS
cord-000248-zueoyesj	477	8	,	,	,
cord-000248-zueoyesj	477	9	which	which	WDT
cord-000248-zueoyesj	477	10	we	-PRON-	PRP
cord-000248-zueoyesj	477	11	will	will	MD
cord-000248-zueoyesj	477	12	call	call	VB
cord-000248-zueoyesj	477	13	M-	M-	NNP
cord-000248-zueoyesj	477	14	Gleason	Gleason	NNP
cord-000248-zueoyesj	477	15	3	3	CD
cord-000248-zueoyesj	477	16	and	and	CC
cord-000248-zueoyesj	477	17	M	M	NNP
cord-000248-zueoyesj	477	18	-	-	HYPH
cord-000248-zueoyesj	477	19	Gleason	Gleason	NNP
cord-000248-zueoyesj	477	20	5	5	CD
cord-000248-zueoyesj	477	21	(	(	-LRB-
cord-000248-zueoyesj	477	22	Figure	Figure	NNP
cord-000248-zueoyesj	477	23	13	13	CD
cord-000248-zueoyesj	477	24	)	)	-RRB-
cord-000248-zueoyesj	477	25	.	.	.
cord-000248-zueoyesj	478	1	The	the	DT
cord-000248-zueoyesj	478	2	names	name	NNS
cord-000248-zueoyesj	478	3	are	be	VBP
cord-000248-zueoyesj	478	4	probably	probably	RB
cord-000248-zueoyesj	478	5	selfexplanatory	selfexplanatory	JJ
cord-000248-zueoyesj	478	6	,	,	,
cord-000248-zueoyesj	478	7	but	but	CC
cord-000248-zueoyesj	478	8	a	a	DT
cord-000248-zueoyesj	478	9	brief	brief	JJ
cord-000248-zueoyesj	478	10	reminder	reminder	NN
cord-000248-zueoyesj	478	11	follows	follow	VBZ
cord-000248-zueoyesj	478	12	.	.	.
cord-000248-zueoyesj	479	1	To	to	TO
cord-000248-zueoyesj	479	2	calculate	calculate	VB
cord-000248-zueoyesj	479	3	the	the	DT
cord-000248-zueoyesj	479	4	MPR	MPR	NNP
cord-000248-zueoyesj	479	5	-	-	HYPH
cord-000248-zueoyesj	479	6	Complexity	Complexity	NNP
cord-000248-zueoyesj	479	7	,	,	,
cord-000248-zueoyesj	479	8	by	by	IN
cord-000248-zueoyesj	479	9	definition	definition	NN
cord-000248-zueoyesj	479	10	,	,	,
cord-000248-zueoyesj	479	11	we	-PRON-	PRP
cord-000248-zueoyesj	479	12	have	have	VBP
cord-000248-zueoyesj	479	13	used	use	VBN
cord-000248-zueoyesj	479	14	the	the	DT
cord-000248-zueoyesj	479	15	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	479	16	distribution	distribution	NN
cord-000248-zueoyesj	479	17	as	as	IN
cord-000248-zueoyesj	479	18	our	-PRON-	PRP$
cord-000248-zueoyesj	479	19	probability	probability	NN
cord-000248-zueoyesj	479	20	distribution	distribution	NN
cord-000248-zueoyesj	479	21	of	of	IN
cord-000248-zueoyesj	479	22	reference	reference	NN
cord-000248-zueoyesj	479	23	(	(	-LRB-
cord-000248-zueoyesj	479	24	for	for	IN
cord-000248-zueoyesj	479	25	the	the	DT
cord-000248-zueoyesj	479	26	computation	computation	NN
cord-000248-zueoyesj	479	27	of	of	IN
cord-000248-zueoyesj	479	28	the	the	DT
cord-000248-zueoyesj	479	29	Jensen	Jensen	NNP
cord-000248-zueoyesj	479	30	-	-	HYPH
cord-000248-zueoyesj	479	31	Shannon	Shannon	NNP
cord-000248-zueoyesj	479	32	Divergence	Divergence	NNP
cord-000248-zueoyesj	479	33	of	of	IN
cord-000248-zueoyesj	479	34	the	the	DT
cord-000248-zueoyesj	479	35	gene	gene	NN
cord-000248-zueoyesj	479	36	expression	expression	NN
cord-000248-zueoyesj	479	37	profile	profile	NN
cord-000248-zueoyesj	479	38	to	to	IN
cord-000248-zueoyesj	479	39	this	this	DT
cord-000248-zueoyesj	479	40	distribution	distribution	NN
cord-000248-zueoyesj	479	41	)	)	-RRB-
cord-000248-zueoyesj	479	42	.	.	.
cord-000248-zueoyesj	480	1	In	in	IN
cord-000248-zueoyesj	480	2	the	the	DT
cord-000248-zueoyesj	480	3	case	case	NN
cord-000248-zueoyesj	480	4	of	of	IN
cord-000248-zueoyesj	480	5	the	the	DT
cord-000248-zueoyesj	480	6	M	M	NNP
cord-000248-zueoyesj	480	7	-	-	HYPH
cord-000248-zueoyesj	480	8	Gleason	Gleason	NNP
cord-000248-zueoyesj	480	9	3	3	CD
cord-000248-zueoyesj	480	10	,	,	,
cord-000248-zueoyesj	480	11	the	the	DT
cord-000248-zueoyesj	480	12	probability	probability	NN
cord-000248-zueoyesj	480	13	distribution	distribution	NN
cord-000248-zueoyesj	480	14	of	of	IN
cord-000248-zueoyesj	480	15	the	the	DT
cord-000248-zueoyesj	480	16	reference	reference	NN
cord-000248-zueoyesj	480	17	is	be	VBZ
cord-000248-zueoyesj	480	18	obtained	obtain	VBN
cord-000248-zueoyesj	480	19	averaging	average	VBG
cord-000248-zueoyesj	480	20	all	all	PDT
cord-000248-zueoyesj	480	21	the	the	DT
cord-000248-zueoyesj	480	22	probability	probability	NN
cord-000248-zueoyesj	480	23	distributions	distribution	NNS
cord-000248-zueoyesj	480	24	of	of	IN
cord-000248-zueoyesj	480	25	the	the	DT
cord-000248-zueoyesj	480	26	samples	sample	NNS
cord-000248-zueoyesj	480	27	that	that	WDT
cord-000248-zueoyesj	480	28	have	have	VBP
cord-000248-zueoyesj	480	29	been	be	VBN
cord-000248-zueoyesj	480	30	labelled	label	VBN
cord-000248-zueoyesj	480	31	as	as	IN
cord-000248-zueoyesj	480	32	Gleason	Gleason	NNP
cord-000248-zueoyesj	480	33	3	3	CD
cord-000248-zueoyesj	480	34	(	(	-LRB-
cord-000248-zueoyesj	480	35	analogously	analogously	RB
cord-000248-zueoyesj	480	36	,	,	,
cord-000248-zueoyesj	480	37	we	-PRON-	PRP
cord-000248-zueoyesj	480	38	calculated	calculate	VBD
cord-000248-zueoyesj	480	39	M-	M-	NNP
cord-000248-zueoyesj	480	40	Gleason	Gleason	NNP
cord-000248-zueoyesj	480	41	5	5	CD
cord-000248-zueoyesj	480	42	)	)	-RRB-
cord-000248-zueoyesj	480	43	.	.	.
cord-000248-zueoyesj	481	1	Samples	sample	NNS
cord-000248-zueoyesj	481	2	that	that	WDT
cord-000248-zueoyesj	481	3	have	have	VBP
cord-000248-zueoyesj	481	4	Gleason	Gleason	NNP
cord-000248-zueoyesj	481	5	pattern	pattern	NN
cord-000248-zueoyesj	481	6	3	3	CD
cord-000248-zueoyesj	481	7	and	and	CC
cord-000248-zueoyesj	481	8	5	5	CD
cord-000248-zueoyesj	481	9	appear	appear	VBP
cord-000248-zueoyesj	481	10	as	as	IN
cord-000248-zueoyesj	481	11	separate	separate	JJ
cord-000248-zueoyesj	481	12	clusters	cluster	NNS
cord-000248-zueoyesj	481	13	in	in	IN
cord-000248-zueoyesj	481	14	the	the	DT
cord-000248-zueoyesj	481	15	(	(	-LRB-
cord-000248-zueoyesj	481	16	M	M	NNP
cord-000248-zueoyesj	481	17	-	-	HYPH
cord-000248-zueoyesj	481	18	Gleason	Gleason	NNP
cord-000248-zueoyesj	481	19	3	3	CD
cord-000248-zueoyesj	481	20	,	,	,
cord-000248-zueoyesj	481	21	M	M	NNP
cord-000248-zueoyesj	481	22	-	-	HYPH
cord-000248-zueoyesj	481	23	Gleason	Gleason	NNP
cord-000248-zueoyesj	481	24	5	5	CD
cord-000248-zueoyesj	481	25	)	)	-RRB-
cord-000248-zueoyesj	481	26	plane	plane	NN
cord-000248-zueoyesj	481	27	with	with	IN
cord-000248-zueoyesj	481	28	the	the	DT
cord-000248-zueoyesj	481	29	two	two	CD
cord-000248-zueoyesj	481	30	putative	putative	JJ
cord-000248-zueoyesj	481	31	outliers	outlier	NNS
cord-000248-zueoyesj	481	32	of	of	IN
cord-000248-zueoyesj	481	33	the	the	DT
cord-000248-zueoyesj	481	34	general	general	JJ
cord-000248-zueoyesj	481	35	trend	trend	NN
cord-000248-zueoyesj	481	36	far	far	RB
cord-000248-zueoyesj	481	37	apart	apart	RB
cord-000248-zueoyesj	481	38	(	(	-LRB-
cord-000248-zueoyesj	481	39	even	even	RB
cord-000248-zueoyesj	481	40	if	if	IN
cord-000248-zueoyesj	481	41	they	-PRON-	PRP
cord-000248-zueoyesj	481	42	have	have	VBP
cord-000248-zueoyesj	481	43	been	be	VBN
cord-000248-zueoyesj	481	44	used	use	VBN
cord-000248-zueoyesj	481	45	to	to	TO
cord-000248-zueoyesj	481	46	calculate	calculate	VB
cord-000248-zueoyesj	481	47	the	the	DT
cord-000248-zueoyesj	481	48	average	average	JJ
cord-000248-zueoyesj	481	49	probability	probability	NN
cord-000248-zueoyesj	481	50	distribution	distribution	NN
cord-000248-zueoyesj	481	51	function	function	NN
cord-000248-zueoyesj	481	52	of	of	IN
cord-000248-zueoyesj	481	53	the	the	DT
cord-000248-zueoyesj	481	54	Gleason	Gleason	NNP
cord-000248-zueoyesj	481	55	3	3	CD
cord-000248-zueoyesj	481	56	pattern	pattern	NN
cord-000248-zueoyesj	481	57	)	)	-RRB-
cord-000248-zueoyesj	481	58	.	.	.
cord-000248-zueoyesj	482	1	Even	even	RB
cord-000248-zueoyesj	482	2	samples	sample	NNS
cord-000248-zueoyesj	482	3	with	with	IN
cord-000248-zueoyesj	482	4	Gleason	Gleason	NNP
cord-000248-zueoyesj	482	5	4	4	CD
cord-000248-zueoyesj	482	6	pattern	pattern	NN
cord-000248-zueoyesj	482	7	are	be	VBP
cord-000248-zueoyesj	482	8	located	locate	VBN
cord-000248-zueoyesj	482	9	closer	close	RBR
cord-000248-zueoyesj	482	10	to	to	IN
cord-000248-zueoyesj	482	11	samples	sample	NNS
cord-000248-zueoyesj	482	12	of	of	IN
cord-000248-zueoyesj	482	13	Gleason	Gleason	NNP
cord-000248-zueoyesj	482	14	patterns	pattern	NNS
cord-000248-zueoyesj	482	15	3	3	CD
cord-000248-zueoyesj	482	16	,	,	,
cord-000248-zueoyesj	482	17	and	and	CC
cord-000248-zueoyesj	482	18	5	5	CD
cord-000248-zueoyesj	482	19	,	,	,
cord-000248-zueoyesj	482	20	indicating	indicate	VBG
cord-000248-zueoyesj	482	21	that	that	IN
cord-000248-zueoyesj	482	22	,	,	,
cord-000248-zueoyesj	482	23	perhaps	perhaps	RB
cord-000248-zueoyesj	482	24	,	,	,
cord-000248-zueoyesj	482	25	there	there	EX
cord-000248-zueoyesj	482	26	exists	exist	VBZ
cord-000248-zueoyesj	482	27	a	a	DT
cord-000248-zueoyesj	482	28	subsampled	subsampled	JJ
cord-000248-zueoyesj	482	29	subtype	subtype	NN
cord-000248-zueoyesj	482	30	of	of	IN
cord-000248-zueoyesj	482	31	prostate	prostate	NN
cord-000248-zueoyesj	482	32	cancer	cancer	NN
cord-000248-zueoyesj	482	33	or	or	CC
cord-000248-zueoyesj	482	34	there	there	EX
cord-000248-zueoyesj	482	35	might	may	MD
cord-000248-zueoyesj	482	36	be	be	VB
cord-000248-zueoyesj	482	37	another	another	DT
cord-000248-zueoyesj	482	38	experimental	experimental	JJ
cord-000248-zueoyesj	482	39	bias	bias	NN
cord-000248-zueoyesj	482	40	or	or	CC
cord-000248-zueoyesj	482	41	factor	factor	NN
cord-000248-zueoyesj	482	42	that	that	IN
cord-000248-zueoyesj	482	43	at	at	IN
cord-000248-zueoyesj	482	44	present	present	NN
cord-000248-zueoyesj	482	45	we	-PRON-	PRP
cord-000248-zueoyesj	482	46	can	can	MD
cord-000248-zueoyesj	482	47	not	not	RB
cord-000248-zueoyesj	482	48	resolve	resolve	VB
cord-000248-zueoyesj	482	49	with	with	IN
cord-000248-zueoyesj	482	50	the	the	DT
cord-000248-zueoyesj	482	51	information	information	NN
cord-000248-zueoyesj	482	52	we	-PRON-	PRP
cord-000248-zueoyesj	482	53	have	have	VBP
cord-000248-zueoyesj	482	54	for	for	IN
cord-000248-zueoyesj	482	55	these	these	DT
cord-000248-zueoyesj	482	56	samples	sample	NNS
cord-000248-zueoyesj	482	57	.	.	.
cord-000248-zueoyesj	483	1	Consequently	consequently	RB
cord-000248-zueoyesj	483	2	,	,	,
cord-000248-zueoyesj	483	3	we	-PRON-	PRP
cord-000248-zueoyesj	483	4	have	have	VBP
cord-000248-zueoyesj	483	5	decided	decide	VBN
cord-000248-zueoyesj	483	6	to	to	TO
cord-000248-zueoyesj	483	7	eliminate	eliminate	VB
cord-000248-zueoyesj	483	8	both	both	DT
cord-000248-zueoyesj	483	9	samples	sample	NNS
cord-000248-zueoyesj	483	10	(	(	-LRB-
cord-000248-zueoyesj	483	11	02	02	CD
cord-000248-zueoyesj	483	12	-	-	SYM
cord-000248-zueoyesj	483	13	003E	003e	CD
cord-000248-zueoyesj	483	14	and	and	CC
cord-000248-zueoyesj	483	15	PNA_03	PNA_03	NNP
cord-000248-zueoyesj	483	16	-	-	HYPH
cord-000248-zueoyesj	483	17	063A	063a	CD
cord-000248-zueoyesj	483	18	)	)	-RRB-
cord-000248-zueoyesj	483	19	from	from	IN
cord-000248-zueoyesj	483	20	further	further	JJ
cord-000248-zueoyesj	483	21	calculations	calculation	NNS
cord-000248-zueoyesj	483	22	.	.	.
cord-000248-zueoyesj	484	1	With	with	IN
cord-000248-zueoyesj	484	2	these	these	DT
cord-000248-zueoyesj	484	3	considerations	consideration	NNS
cord-000248-zueoyesj	484	4	,	,	,
cord-000248-zueoyesj	484	5	we	-PRON-	PRP
cord-000248-zueoyesj	484	6	now	now	RB
cord-000248-zueoyesj	484	7	have	have	VBP
cord-000248-zueoyesj	484	8	a	a	DT
cord-000248-zueoyesj	484	9	dataset	dataset	NN
cord-000248-zueoyesj	484	10	with	with	IN
cord-000248-zueoyesj	484	11	13,188	13,188	CD
cord-000248-zueoyesj	484	12	probes	probe	NNS
cord-000248-zueoyesj	484	13	and	and	CC
cord-000248-zueoyesj	484	14	29	29	CD
cord-000248-zueoyesj	484	15	samples	sample	NNS
cord-000248-zueoyesj	484	16	as	as	IN
cord-000248-zueoyesj	484	17	our	-PRON-	PRP$
cord-000248-zueoyesj	484	18	dataset	dataset	NN
cord-000248-zueoyesj	484	19	for	for	IN
cord-000248-zueoyesj	484	20	further	further	JJ
cord-000248-zueoyesj	484	21	analysis	analysis	NN
cord-000248-zueoyesj	484	22	.	.	.
cord-000248-zueoyesj	485	1	Figure	figure	NN
cord-000248-zueoyesj	485	2	14	14	CD
cord-000248-zueoyesj	485	3	shows	show	VBZ
cord-000248-zueoyesj	485	4	the	the	DT
cord-000248-zueoyesj	485	5	distribution	distribution	NN
cord-000248-zueoyesj	485	6	of	of	IN
cord-000248-zueoyesj	485	7	the	the	DT
cord-000248-zueoyesj	485	8	samples	sample	NNS
cord-000248-zueoyesj	485	9	using	use	VBG
cord-000248-zueoyesj	485	10	the	the	DT
cord-000248-zueoyesj	485	11	Normalized	Normalized	NNP
cord-000248-zueoyesj	485	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	485	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	485	14	and	and	CC
cord-000248-zueoyesj	485	15	the	the	DT
cord-000248-zueoyesj	485	16	MPR	mpr	NN
cord-000248-zueoyesj	485	17	-	-	HYPH
cord-000248-zueoyesj	485	18	complexity	complexity	NN
cord-000248-zueoyesj	485	19	.	.	.
cord-000248-zueoyesj	486	1	By	by	IN
cord-000248-zueoyesj	486	2	definition	definition	NN
cord-000248-zueoyesj	486	3	,	,	,
cord-000248-zueoyesj	486	4	the	the	DT
cord-000248-zueoyesj	486	5	positions	position	NNS
cord-000248-zueoyesj	486	6	of	of	IN
cord-000248-zueoyesj	486	7	the	the	DT
cord-000248-zueoyesj	486	8	29	29	CD
cord-000248-zueoyesj	486	9	samples	sample	NNS
cord-000248-zueoyesj	486	10	in	in	IN
cord-000248-zueoyesj	486	11	the	the	DT
cord-000248-zueoyesj	486	12	plane	plane	NN
cord-000248-zueoyesj	486	13	do	do	VBP
cord-000248-zueoyesj	486	14	not	not	RB
cord-000248-zueoyesj	486	15	change	change	VB
cord-000248-zueoyesj	486	16	(	(	-LRB-
cord-000248-zueoyesj	486	17	this	this	DT
cord-000248-zueoyesj	486	18	figure	figure	NN
cord-000248-zueoyesj	486	19	is	be	VBZ
cord-000248-zueoyesj	486	20	basically	basically	RB
cord-000248-zueoyesj	486	21	'	'	''
cord-000248-zueoyesj	486	22	'	'	``
cord-000248-zueoyesj	486	23	zooming	zoom	VBG
cord-000248-zueoyesj	486	24	in	in	RP
cord-000248-zueoyesj	486	25	'	'	''
cord-000248-zueoyesj	486	26	'	'	''
cord-000248-zueoyesj	487	1	one	one	CD
cord-000248-zueoyesj	487	2	region	region	NN
cord-000248-zueoyesj	487	3	of	of	IN
cord-000248-zueoyesj	487	4	Figure	figure	NN
cord-000248-zueoyesj	487	5	12	12	CD
cord-000248-zueoyesj	487	6	that	that	WDT
cord-000248-zueoyesj	487	7	contains	contain	VBZ
cord-000248-zueoyesj	487	8	these	these	DT
cord-000248-zueoyesj	487	9	samples	sample	NNS
cord-000248-zueoyesj	487	10	)	)	-RRB-
cord-000248-zueoyesj	487	11	.	.	.
cord-000248-zueoyesj	488	1	We	-PRON-	PRP
cord-000248-zueoyesj	488	2	note	note	VBP
cord-000248-zueoyesj	488	3	again	again	RB
cord-000248-zueoyesj	488	4	,	,	,
cord-000248-zueoyesj	488	5	however	however	RB
cord-000248-zueoyesj	488	6	,	,	,
cord-000248-zueoyesj	488	7	that	that	IN
cord-000248-zueoyesj	488	8	the	the	DT
cord-000248-zueoyesj	488	9	29	29	CD
cord-000248-zueoyesj	488	10	samples	sample	NNS
cord-000248-zueoyesj	488	11	seem	seem	VBP
cord-000248-zueoyesj	488	12	to	to	TO
cord-000248-zueoyesj	488	13	be	be	VB
cord-000248-zueoyesj	488	14	separating	separate	VBG
cord-000248-zueoyesj	488	15	in	in	IN
cord-000248-zueoyesj	488	16	three	three	CD
cord-000248-zueoyesj	488	17	different	different	JJ
cord-000248-zueoyesj	488	18	clusters	cluster	NNS
cord-000248-zueoyesj	488	19	.	.	.
cord-000248-zueoyesj	489	1	Whether	whether	IN
cord-000248-zueoyesj	489	2	we	-PRON-	PRP
cord-000248-zueoyesj	489	3	can	can	MD
cord-000248-zueoyesj	489	4	argue	argue	VB
cord-000248-zueoyesj	489	5	about	about	IN
cord-000248-zueoyesj	489	6	the	the	DT
cord-000248-zueoyesj	489	7	existence	existence	NN
cord-000248-zueoyesj	489	8	or	or	CC
cord-000248-zueoyesj	489	9	not	not	RB
cord-000248-zueoyesj	489	10	of	of	IN
cord-000248-zueoyesj	489	11	these	these	DT
cord-000248-zueoyesj	489	12	gaps	gap	NNS
cord-000248-zueoyesj	489	13	in	in	IN
cord-000248-zueoyesj	489	14	Normalized	Normalized	NNP
cord-000248-zueoyesj	489	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	489	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	489	17	,	,	,
cord-000248-zueoyesj	489	18	it	-PRON-	PRP
cord-000248-zueoyesj	489	19	is	be	VBZ
cord-000248-zueoyesj	489	20	clear	clear	JJ
cord-000248-zueoyesj	489	21	that	that	IN
cord-000248-zueoyesj	489	22	there	there	EX
cord-000248-zueoyesj	489	23	seems	seem	VBZ
cord-000248-zueoyesj	489	24	to	to	TO
cord-000248-zueoyesj	489	25	be	be	VB
cord-000248-zueoyesj	489	26	a	a	DT
cord-000248-zueoyesj	489	27	progression	progression	NN
cord-000248-zueoyesj	489	28	as	as	IN
cord-000248-zueoyesj	489	29	we	-PRON-	PRP
cord-000248-zueoyesj	489	30	have	have	VBP
cord-000248-zueoyesj	489	31	seen	see	VBN
cord-000248-zueoyesj	489	32	with	with	IN
cord-000248-zueoyesj	489	33	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	489	34	et	et	FW
cord-000248-zueoyesj	489	35	al	al	NNP
cord-000248-zueoyesj	489	36	's	's	POS
cord-000248-zueoyesj	489	37	dataset	dataset	NN
cord-000248-zueoyesj	489	38	.	.	.
cord-000248-zueoyesj	490	1	There	there	EX
cord-000248-zueoyesj	490	2	is	be	VBZ
cord-000248-zueoyesj	490	3	a	a	DT
cord-000248-zueoyesj	490	4	group	group	NN
cord-000248-zueoyesj	490	5	of	of	IN
cord-000248-zueoyesj	490	6	three	three	CD
cord-000248-zueoyesj	490	7	samples	sample	NNS
cord-000248-zueoyesj	490	8	with	with	IN
cord-000248-zueoyesj	490	9	Gleason	Gleason	NNP
cord-000248-zueoyesj	490	10	pattern	pattern	NN
cord-000248-zueoyesj	490	11	3	3	CD
cord-000248-zueoyesj	490	12	that	that	WDT
cord-000248-zueoyesj	490	13	seem	seem	VBP
cord-000248-zueoyesj	490	14	to	to	TO
cord-000248-zueoyesj	490	15	have	have	VB
cord-000248-zueoyesj	490	16	the	the	DT
cord-000248-zueoyesj	490	17	the	the	DT
cord-000248-zueoyesj	490	18	largest	large	JJS
cord-000248-zueoyesj	490	19	Normalized	Normalized	NNP
cord-000248-zueoyesj	490	20	Shannon	Shannon	NNP
cord-000248-zueoyesj	490	21	Entropy	Entropy	NNP
cord-000248-zueoyesj	490	22	values	value	NNS
cord-000248-zueoyesj	490	23	.	.	.
cord-000248-zueoyesj	491	1	There	there	EX
cord-000248-zueoyesj	491	2	is	be	VBZ
cord-000248-zueoyesj	491	3	also	also	RB
cord-000248-zueoyesj	491	4	a	a	DT
cord-000248-zueoyesj	491	5	cluster	cluster	NN
cord-000248-zueoyesj	491	6	that	that	WDT
cord-000248-zueoyesj	491	7	only	only	RB
cord-000248-zueoyesj	491	8	contains	contain	VBZ
cord-000248-zueoyesj	491	9	samples	sample	NNS
cord-000248-zueoyesj	491	10	of	of	IN
cord-000248-zueoyesj	491	11	either	either	CC
cord-000248-zueoyesj	491	12	Gleason	Gleason	NNP
cord-000248-zueoyesj	491	13	pattern	pattern	NN
cord-000248-zueoyesj	491	14	4	4	CD
cord-000248-zueoyesj	491	15	and	and	CC
cord-000248-zueoyesj	491	16	5	5	CD
cord-000248-zueoyesj	491	17	,	,	,
cord-000248-zueoyesj	491	18	all	all	DT
cord-000248-zueoyesj	491	19	with	with	IN
cord-000248-zueoyesj	491	20	Normalized	Normalized	NNP
cord-000248-zueoyesj	491	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	491	22	Entropy	Entropy	NNP
cord-000248-zueoyesj	491	23	values	value	VBZ
cord-000248-zueoyesj	491	24	smaller	small	JJR
cord-000248-zueoyesj	491	25	than	than	IN
cord-000248-zueoyesj	491	26	0.985	0.985	CD
cord-000248-zueoyesj	491	27	.	.	.
cord-000248-zueoyesj	492	1	There	there	EX
cord-000248-zueoyesj	492	2	is	be	VBZ
cord-000248-zueoyesj	492	3	also	also	RB
cord-000248-zueoyesj	492	4	very	very	RB
cord-000248-zueoyesj	492	5	little	little	JJ
cord-000248-zueoyesj	492	6	variation	variation	NN
cord-000248-zueoyesj	492	7	(	(	-LRB-
cord-000248-zueoyesj	492	8	see	see	VB
cord-000248-zueoyesj	492	9	Figure	Figure	NNP
cord-000248-zueoyesj	492	10	15	15	CD
cord-000248-zueoyesj	492	11	)	)	-RRB-
cord-000248-zueoyesj	492	12	of	of	IN
cord-000248-zueoyesj	492	13	the	the	DT
cord-000248-zueoyesj	492	14	positions	position	NNS
cord-000248-zueoyesj	492	15	of	of	IN
cord-000248-zueoyesj	492	16	the	the	DT
cord-000248-zueoyesj	492	17	29	29	CD
cord-000248-zueoyesj	492	18	samples	sample	NNS
cord-000248-zueoyesj	492	19	on	on	IN
cord-000248-zueoyesj	492	20	the	the	DT
cord-000248-zueoyesj	492	21	(	(	-LRB-
cord-000248-zueoyesj	492	22	M	M	NNP
cord-000248-zueoyesj	492	23	-	-	HYPH
cord-000248-zueoyesj	492	24	Gleason	Gleason	NNP
cord-000248-zueoyesj	492	25	3	3	CD
cord-000248-zueoyesj	492	26	,	,	,
cord-000248-zueoyesj	492	27	M	M	NNP
cord-000248-zueoyesj	492	28	-	-	HYPH
cord-000248-zueoyesj	492	29	Gleason	Gleason	NNP
cord-000248-zueoyesj	492	30	5)-plane	5)-plane	CD
cord-000248-zueoyesj	492	31	,	,	,
cord-000248-zueoyesj	492	32	indicating	indicate	VBG
cord-000248-zueoyesj	492	33	a	a	DT
cord-000248-zueoyesj	492	34	degree	degree	NN
cord-000248-zueoyesj	492	35	of	of	IN
cord-000248-zueoyesj	492	36	robustness	robustness	NN
cord-000248-zueoyesj	492	37	that	that	IN
cord-000248-zueoyesj	492	38	the	the	DT
cord-000248-zueoyesj	492	39	computation	computation	NN
cord-000248-zueoyesj	492	40	of	of	IN
cord-000248-zueoyesj	492	41	these	these	DT
cord-000248-zueoyesj	492	42	modified	modify	VBN
cord-000248-zueoyesj	492	43	complexities	complexity	NNS
cord-000248-zueoyesj	492	44	have	have	VBP
cord-000248-zueoyesj	492	45	,	,	,
cord-000248-zueoyesj	492	46	even	even	RB
cord-000248-zueoyesj	492	47	in	in	IN
cord-000248-zueoyesj	492	48	the	the	DT
cord-000248-zueoyesj	492	49	presence	presence	NN
cord-000248-zueoyesj	492	50	of	of	IN
cord-000248-zueoyesj	492	51	some	some	DT
cord-000248-zueoyesj	492	52	outliers	outlier	NNS
cord-000248-zueoyesj	492	53	.	.	.
cord-000248-zueoyesj	493	1	After	after	IN
cord-000248-zueoyesj	493	2	observing	observe	VBG
cord-000248-zueoyesj	493	3	that	that	DT
cord-000248-zueoyesj	493	4	Figure	figure	NN
cord-000248-zueoyesj	493	5	14	14	CD
cord-000248-zueoyesj	493	6	shows	show	VBZ
cord-000248-zueoyesj	493	7	a	a	DT
cord-000248-zueoyesj	493	8	correlation	correlation	NN
cord-000248-zueoyesj	493	9	of	of	IN
cord-000248-zueoyesj	493	10	Gleason	Gleason	NNP
cord-000248-zueoyesj	493	11	pattern	pattern	NN
cord-000248-zueoyesj	493	12	score	score	NN
cord-000248-zueoyesj	493	13	with	with	IN
cord-000248-zueoyesj	493	14	Normalized	Normalized	NNP
cord-000248-zueoyesj	493	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	493	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	493	17	,	,	,
cord-000248-zueoyesj	493	18	we	-PRON-	PRP
cord-000248-zueoyesj	493	19	asked	ask	VBD
cord-000248-zueoyesj	493	20	ourselves	-PRON-	PRP
cord-000248-zueoyesj	493	21	:	:	:
cord-000248-zueoyesj	493	22	'	'	''
cord-000248-zueoyesj	493	23	which	which	WDT
cord-000248-zueoyesj	493	24	are	be	VBP
cord-000248-zueoyesj	493	25	the	the	DT
cord-000248-zueoyesj	493	26	genes	gene	NNS
cord-000248-zueoyesj	493	27	that	that	WDT
cord-000248-zueoyesj	493	28	most	most	RBS
cord-000248-zueoyesj	493	29	positively	positively	RB
cord-000248-zueoyesj	493	30	and	and	CC
cord-000248-zueoyesj	493	31	negatively	negatively	RB
cord-000248-zueoyesj	493	32	correlate	correlate	VB
cord-000248-zueoyesj	493	33	with	with	IN
cord-000248-zueoyesj	493	34	the	the	DT
cord-000248-zueoyesj	493	35	transitions	transition	NNS
cord-000248-zueoyesj	493	36	of	of	IN
cord-000248-zueoyesj	493	37	Normalized	Normalized	NNP
cord-000248-zueoyesj	493	38	Shannon	Shannon	NNP
cord-000248-zueoyesj	493	39	Entropy	Entropy	NNP
cord-000248-zueoyesj	493	40	?	?	.
cord-000248-zueoyesj	493	41	'	'	''
cord-000248-zueoyesj	494	1	We	-PRON-	PRP
cord-000248-zueoyesj	494	2	have	have	VBP
cord-000248-zueoyesj	494	3	plotted	plot	VBN
cord-000248-zueoyesj	494	4	Spearman	Spearman	NNP
cord-000248-zueoyesj	494	5	versus	versus	IN
cord-000248-zueoyesj	494	6	Pearson	Pearson	NNP
cord-000248-zueoyesj	494	7	correlation	correlation	NN
cord-000248-zueoyesj	494	8	values	value	NNS
cord-000248-zueoyesj	494	9	of	of	IN
cord-000248-zueoyesj	494	10	probe	probe	NN
cord-000248-zueoyesj	494	11	expressions	expression	NNS
cord-000248-zueoyesj	494	12	to	to	TO
cord-000248-zueoyesj	494	13	attempt	attempt	VB
cord-000248-zueoyesj	494	14	to	to	TO
cord-000248-zueoyesj	494	15	find	find	VB
cord-000248-zueoyesj	494	16	those	those	DT
cord-000248-zueoyesj	494	17	that	that	WDT
cord-000248-zueoyesj	494	18	best	well	RBS
cord-000248-zueoyesj	494	19	correlate	correlate	VBP
cord-000248-zueoyesj	494	20	,	,	,
cord-000248-zueoyesj	494	21	either	either	CC
cord-000248-zueoyesj	494	22	positively	positively	RB
cord-000248-zueoyesj	494	23	or	or	CC
cord-000248-zueoyesj	494	24	negatively	negatively	RB
cord-000248-zueoyesj	494	25	,	,	,
cord-000248-zueoyesj	494	26	with	with	IN
cord-000248-zueoyesj	494	27	the	the	DT
cord-000248-zueoyesj	494	28	Normalized	Normalized	NNP
cord-000248-zueoyesj	494	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	494	30	Entropy	Entropy	NNP
cord-000248-zueoyesj	494	31	values	value	NNS
cord-000248-zueoyesj	494	32	of	of	IN
cord-000248-zueoyesj	494	33	the	the	DT
cord-000248-zueoyesj	494	34	samples	sample	NNS
cord-000248-zueoyesj	494	35	.	.	.
cord-000248-zueoyesj	495	1	The	the	DT
cord-000248-zueoyesj	495	2	results	result	NNS
cord-000248-zueoyesj	495	3	have	have	VBP
cord-000248-zueoyesj	495	4	revealed	reveal	VBN
cord-000248-zueoyesj	495	5	some	some	DT
cord-000248-zueoyesj	495	6	of	of	IN
cord-000248-zueoyesj	495	7	the	the	DT
cord-000248-zueoyesj	495	8	most	most	RBS
cord-000248-zueoyesj	495	9	relevant	relevant	JJ
cord-000248-zueoyesj	495	10	biomarkers	biomarker	NNS
cord-000248-zueoyesj	495	11	of	of	IN
cord-000248-zueoyesj	495	12	progression	progression	NN
cord-000248-zueoyesj	495	13	,	,	,
cord-000248-zueoyesj	495	14	and	and	CC
cord-000248-zueoyesj	495	15	some	some	DT
cord-000248-zueoyesj	495	16	unexpected	unexpected	JJ
cord-000248-zueoyesj	495	17	newcomers	newcomer	NNS
cord-000248-zueoyesj	495	18	.	.	.
cord-000248-zueoyesj	496	1	Figure	figure	NN
cord-000248-zueoyesj	496	2	16	16	CD
cord-000248-zueoyesj	496	3	shows	show	VBZ
cord-000248-zueoyesj	496	4	the	the	DT
cord-000248-zueoyesj	496	5	Pearson	Pearson	NNP
cord-000248-zueoyesj	496	6	and	and	CC
cord-000248-zueoyesj	496	7	Spearman	Spearman	NNP
cord-000248-zueoyesj	496	8	correlations	correlation	NNS
cord-000248-zueoyesj	496	9	of	of	IN
cord-000248-zueoyesj	496	10	all	all	PDT
cord-000248-zueoyesj	496	11	the	the	DT
cord-000248-zueoyesj	496	12	13,188	13,188	CD
cord-000248-zueoyesj	496	13	probes	probe	NNS
cord-000248-zueoyesj	496	14	in	in	IN
cord-000248-zueoyesj	496	15	the	the	DT
cord-000248-zueoyesj	496	16	dataset	dataset	NN
cord-000248-zueoyesj	496	17	with	with	IN
cord-000248-zueoyesj	496	18	the	the	DT
cord-000248-zueoyesj	496	19	Normalized	Normalized	NNP
cord-000248-zueoyesj	496	20	Shannon	Shannon	NNP
cord-000248-zueoyesj	496	21	Entropy	Entropy	NNP
cord-000248-zueoyesj	496	22	values	value	NNS
cord-000248-zueoyesj	496	23	of	of	IN
cord-000248-zueoyesj	496	24	the	the	DT
cord-000248-zueoyesj	496	25	samples	sample	NNS
cord-000248-zueoyesj	496	26	.	.	.
cord-000248-zueoyesj	497	1	We	-PRON-	PRP
cord-000248-zueoyesj	497	2	have	have	VBP
cord-000248-zueoyesj	497	3	highlighted	highlight	VBN
cord-000248-zueoyesj	497	4	some	some	DT
cord-000248-zueoyesj	497	5	particular	particular	JJ
cord-000248-zueoyesj	497	6	genes	gene	NNS
cord-000248-zueoyesj	497	7	that	that	WDT
cord-000248-zueoyesj	497	8	are	be	VBP
cord-000248-zueoyesj	497	9	discussed	discuss	VBN
cord-000248-zueoyesj	497	10	below	below	RB
cord-000248-zueoyesj	497	11	.	.	.
cord-000248-zueoyesj	498	1	CDKN2C	CDKN2C	NNP
cord-000248-zueoyesj	499	1	(	(	-LRB-
cord-000248-zueoyesj	499	2	cyclin	cyclin	NN
cord-000248-zueoyesj	499	3	-	-	HYPH
cord-000248-zueoyesj	499	4	dependent	dependent	JJ
cord-000248-zueoyesj	499	5	kinase	kinase	NN
cord-000248-zueoyesj	499	6	inhibitor	inhibitor	NN
cord-000248-zueoyesj	499	7	2C	2C	NNP
cord-000248-zueoyesj	499	8	(	(	-LRB-
cord-000248-zueoyesj	499	9	p18	p18	NN
cord-000248-zueoyesj	499	10	,	,	,
cord-000248-zueoyesj	499	11	inhibits	inhibit	VBZ
cord-000248-zueoyesj	499	12	CDK4	CDK4	NNP
cord-000248-zueoyesj	499	13	)	)	-RRB-
cord-000248-zueoyesj	499	14	.	.	.
cord-000248-zueoyesj	500	1	When	when	WRB
cord-000248-zueoyesj	500	2	we	-PRON-	PRP
cord-000248-zueoyesj	500	3	compute	compute	VBP
cord-000248-zueoyesj	500	4	the	the	DT
cord-000248-zueoyesj	500	5	correlations	correlation	NNS
cord-000248-zueoyesj	500	6	of	of	IN
cord-000248-zueoyesj	500	7	the	the	DT
cord-000248-zueoyesj	500	8	probes	probe	NNS
cord-000248-zueoyesj	500	9	expressions	expression	NNS
cord-000248-zueoyesj	500	10	with	with	IN
cord-000248-zueoyesj	500	11	the	the	DT
cord-000248-zueoyesj	500	12	Normalized	Normalized	NNP
cord-000248-zueoyesj	500	13	Shannon	Shannon	NNP
cord-000248-zueoyesj	500	14	Entropy	Entropy	NNP
cord-000248-zueoyesj	500	15	values	value	NNS
cord-000248-zueoyesj	500	16	of	of	IN
cord-000248-zueoyesj	500	17	the	the	DT
cord-000248-zueoyesj	500	18	samples	sample	NNS
cord-000248-zueoyesj	500	19	,	,	,
cord-000248-zueoyesj	500	20	the	the	DT
cord-000248-zueoyesj	500	21	gene	gene	NN
cord-000248-zueoyesj	500	22	that	that	WDT
cord-000248-zueoyesj	500	23	has	have	VBZ
cord-000248-zueoyesj	500	24	the	the	DT
cord-000248-zueoyesj	500	25	most	most	RBS
cord-000248-zueoyesj	500	26	negative	negative	JJ
cord-000248-zueoyesj	500	27	correlations	correlation	NNS
cord-000248-zueoyesj	500	28	is	be	VBZ
cord-000248-zueoyesj	500	29	CDKN2C	cdkn2c	JJ
cord-000248-zueoyesj	500	30	(	(	-LRB-
cord-000248-zueoyesj	500	31	cyclin	cyclin	NN
cord-000248-zueoyesj	500	32	-	-	HYPH
cord-000248-zueoyesj	500	33	dependent	dependent	JJ
cord-000248-zueoyesj	500	34	kinase	kinase	NN
cord-000248-zueoyesj	500	35	inhibitor	inhibitor	NN
cord-000248-zueoyesj	500	36	2C	2C	NNP
cord-000248-zueoyesj	500	37	-p18	-p18	NNP
cord-000248-zueoyesj	500	38	,	,	,
cord-000248-zueoyesj	500	39	inhibits	inhibit	VBZ
cord-000248-zueoyesj	500	40	CDK4	CDK4	NNP
cord-000248-zueoyesj	500	41	-NM_078626	-NM_078626	NNS
cord-000248-zueoyesj	500	42	)	)	-RRB-
cord-000248-zueoyesj	500	43	,	,	,
cord-000248-zueoyesj	500	44	which	which	WDT
cord-000248-zueoyesj	500	45	has	have	VBZ
cord-000248-zueoyesj	500	46	been	be	VBN
cord-000248-zueoyesj	500	47	previously	previously	RB
cord-000248-zueoyesj	500	48	associated	associate	VBN
cord-000248-zueoyesj	500	49	with	with	IN
cord-000248-zueoyesj	500	50	the	the	DT
cord-000248-zueoyesj	500	51	transition	transition	NN
cord-000248-zueoyesj	500	52	from	from	IN
cord-000248-zueoyesj	500	53	prostatic	prostatic	JJ
cord-000248-zueoyesj	500	54	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	500	55	neoplasia	neoplasia	NN
cord-000248-zueoyesj	500	56	(	(	-LRB-
cord-000248-zueoyesj	500	57	PIN	pin	NN
cord-000248-zueoyesj	500	58	)	)	-RRB-
cord-000248-zueoyesj	500	59	to	to	IN
cord-000248-zueoyesj	500	60	prostate	prostate	NN
cord-000248-zueoyesj	500	61	cancer	cancer	NN
cord-000248-zueoyesj	501	1	[	[	-LRB-
cord-000248-zueoyesj	501	2	68	68	CD
cord-000248-zueoyesj	501	3	]	]	-RRB-
cord-000248-zueoyesj	501	4	Figure	figure	NN
cord-000248-zueoyesj	501	5	12	12	CD
cord-000248-zueoyesj	501	6	.	.	.
cord-000248-zueoyesj	502	1	We	-PRON-	PRP
cord-000248-zueoyesj	502	2	plot	plot	VBP
cord-000248-zueoyesj	502	3	the	the	DT
cord-000248-zueoyesj	502	4	values	value	NNS
cord-000248-zueoyesj	502	5	of	of	IN
cord-000248-zueoyesj	502	6	two	two	CD
cord-000248-zueoyesj	502	7	modified	modify	VBN
cord-000248-zueoyesj	502	8	statistical	statistical	JJ
cord-000248-zueoyesj	502	9	complexities	complexity	NNS
cord-000248-zueoyesj	502	10	,	,	,
cord-000248-zueoyesj	502	11	which	which	WDT
cord-000248-zueoyesj	502	12	we	-PRON-	PRP
cord-000248-zueoyesj	502	13	will	will	MD
cord-000248-zueoyesj	502	14	call	call	VB
cord-000248-zueoyesj	502	15	M	M	NNP
cord-000248-zueoyesj	502	16	-	-	HYPH
cord-000248-zueoyesj	502	17	Gleason	Gleason	NNP
cord-000248-zueoyesj	502	18	3	3	CD
cord-000248-zueoyesj	502	19	and	and	CC
cord-000248-zueoyesj	502	20	M-	M-	NNP
cord-000248-zueoyesj	502	21	Gleason	Gleason	NNP
cord-000248-zueoyesj	502	22	5	5	CD
cord-000248-zueoyesj	502	23	.	.	.
cord-000248-zueoyesj	503	1	Instead	instead	RB
cord-000248-zueoyesj	503	2	of	of	IN
cord-000248-zueoyesj	503	3	using	use	VBG
cord-000248-zueoyesj	503	4	the	the	DT
cord-000248-zueoyesj	503	5	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	503	6	distribution	distribution	NN
cord-000248-zueoyesj	503	7	as	as	IN
cord-000248-zueoyesj	503	8	our	-PRON-	PRP$
cord-000248-zueoyesj	503	9	probability	probability	NN
cord-000248-zueoyesj	503	10	distribution	distribution	NN
cord-000248-zueoyesj	503	11	of	of	IN
cord-000248-zueoyesj	503	12	reference	reference	NN
cord-000248-zueoyesj	503	13	(	(	-LRB-
cord-000248-zueoyesj	503	14	for	for	IN
cord-000248-zueoyesj	503	15	the	the	DT
cord-000248-zueoyesj	503	16	computation	computation	NN
cord-000248-zueoyesj	503	17	of	of	IN
cord-000248-zueoyesj	503	18	the	the	DT
cord-000248-zueoyesj	503	19	Jensen	Jensen	NNP
cord-000248-zueoyesj	503	20	-	-	HYPH
cord-000248-zueoyesj	503	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	503	22	Divergence	Divergence	NNP
cord-000248-zueoyesj	503	23	of	of	IN
cord-000248-zueoyesj	503	24	the	the	DT
cord-000248-zueoyesj	503	25	gene	gene	NN
cord-000248-zueoyesj	503	26	expression	expression	NN
cord-000248-zueoyesj	503	27	profile	profile	NN
cord-000248-zueoyesj	503	28	to	to	IN
cord-000248-zueoyesj	503	29	this	this	DT
cord-000248-zueoyesj	503	30	distribution	distribution	NN
cord-000248-zueoyesj	503	31	)	)	-RRB-
cord-000248-zueoyesj	503	32	,	,	,
cord-000248-zueoyesj	503	33	as	as	IN
cord-000248-zueoyesj	503	34	required	require	VBN
cord-000248-zueoyesj	503	35	for	for	IN
cord-000248-zueoyesj	503	36	the	the	DT
cord-000248-zueoyesj	503	37	MPR	MPR	NNP
cord-000248-zueoyesj	503	38	-	-	HYPH
cord-000248-zueoyesj	503	39	Statistical	Statistical	NNP
cord-000248-zueoyesj	503	40	Complexity	Complexity	NNP
cord-000248-zueoyesj	503	41	calculation	calculation	NN
cord-000248-zueoyesj	503	42	,	,	,
cord-000248-zueoyesj	503	43	we	-PRON-	PRP
cord-000248-zueoyesj	503	44	used	use	VBD
cord-000248-zueoyesj	503	45	a	a	DT
cord-000248-zueoyesj	503	46	different	different	JJ
cord-000248-zueoyesj	503	47	one	one	CD
cord-000248-zueoyesj	503	48	.	.	.
cord-000248-zueoyesj	504	1	For	for	IN
cord-000248-zueoyesj	504	2	the	the	DT
cord-000248-zueoyesj	504	3	M	M	NNP
cord-000248-zueoyesj	504	4	-	-	HYPH
cord-000248-zueoyesj	504	5	Gleason	Gleason	NNP
cord-000248-zueoyesj	504	6	3	3	CD
cord-000248-zueoyesj	504	7	,	,	,
cord-000248-zueoyesj	504	8	the	the	DT
cord-000248-zueoyesj	504	9	probability	probability	NN
cord-000248-zueoyesj	504	10	distribution	distribution	NN
cord-000248-zueoyesj	504	11	of	of	IN
cord-000248-zueoyesj	504	12	the	the	DT
cord-000248-zueoyesj	504	13	reference	reference	NN
cord-000248-zueoyesj	504	14	is	be	VBZ
cord-000248-zueoyesj	504	15	obtained	obtain	VBN
cord-000248-zueoyesj	504	16	averaging	average	VBG
cord-000248-zueoyesj	504	17	all	all	PDT
cord-000248-zueoyesj	504	18	the	the	DT
cord-000248-zueoyesj	504	19	probability	probability	NN
cord-000248-zueoyesj	504	20	distributions	distribution	NNS
cord-000248-zueoyesj	504	21	of	of	IN
cord-000248-zueoyesj	504	22	the	the	DT
cord-000248-zueoyesj	504	23	samples	sample	NNS
cord-000248-zueoyesj	504	24	that	that	WDT
cord-000248-zueoyesj	504	25	have	have	VBP
cord-000248-zueoyesj	504	26	been	be	VBN
cord-000248-zueoyesj	504	27	labelled	label	VBN
cord-000248-zueoyesj	504	28	as	as	IN
cord-000248-zueoyesj	504	29	Gleason	Gleason	NNP
cord-000248-zueoyesj	504	30	3	3	CD
cord-000248-zueoyesj	504	31	(	(	-LRB-
cord-000248-zueoyesj	504	32	analogously	analogously	RB
cord-000248-zueoyesj	504	33	,	,	,
cord-000248-zueoyesj	504	34	we	-PRON-	PRP
cord-000248-zueoyesj	504	35	calculated	calculate	VBD
cord-000248-zueoyesj	504	36	M-	M-	NNP
cord-000248-zueoyesj	504	37	Gleason	Gleason	NNP
cord-000248-zueoyesj	504	38	5	5	CD
cord-000248-zueoyesj	504	39	)	)	-RRB-
cord-000248-zueoyesj	504	40	.	.	.
cord-000248-zueoyesj	505	1	This	this	DT
cord-000248-zueoyesj	505	2	is	be	VBZ
cord-000248-zueoyesj	505	3	analogous	analogous	JJ
cord-000248-zueoyesj	505	4	to	to	IN
cord-000248-zueoyesj	505	5	our	-PRON-	PRP$
cord-000248-zueoyesj	505	6	approach	approach	NN
cord-000248-zueoyesj	505	7	in	in	IN
cord-000248-zueoyesj	505	8	melanoma	melanoma	NN
cord-000248-zueoyesj	505	9	(	(	-LRB-
cord-000248-zueoyesj	505	10	Figure	figure	NN
cord-000248-zueoyesj	505	11	5	5	CD
cord-000248-zueoyesj	505	12	)	)	-RRB-
cord-000248-zueoyesj	505	13	in	in	IN
cord-000248-zueoyesj	505	14	which	which	WDT
cord-000248-zueoyesj	505	15	we	-PRON-	PRP
cord-000248-zueoyesj	505	16	used	use	VBD
cord-000248-zueoyesj	505	17	normal	normal	JJ
cord-000248-zueoyesj	505	18	and	and	CC
cord-000248-zueoyesj	505	19	metastatic	metastatic	JJ
cord-000248-zueoyesj	505	20	samples	sample	NNS
cord-000248-zueoyesj	505	21	as	as	IN
cord-000248-zueoyesj	505	22	reference	reference	NN
cord-000248-zueoyesj	505	23	sets	set	NNS
cord-000248-zueoyesj	505	24	for	for	IN
cord-000248-zueoyesj	505	25	a	a	DT
cord-000248-zueoyesj	505	26	modified	modify	VBN
cord-000248-zueoyesj	505	27	statistical	statistical	JJ
cord-000248-zueoyesj	505	28	complexity	complexity	NN
cord-000248-zueoyesj	505	29	.	.	.
cord-000248-zueoyesj	506	1	We	-PRON-	PRP
cord-000248-zueoyesj	506	2	observe	observe	VBP
cord-000248-zueoyesj	506	3	that	that	IN
cord-000248-zueoyesj	506	4	,	,	,
cord-000248-zueoyesj	506	5	even	even	RB
cord-000248-zueoyesj	506	6	in	in	IN
cord-000248-zueoyesj	506	7	this	this	DT
cord-000248-zueoyesj	506	8	case	case	NN
cord-000248-zueoyesj	506	9	,	,	,
cord-000248-zueoyesj	506	10	02_003E	02_003e	CD
cord-000248-zueoyesj	506	11	and	and	CC
cord-000248-zueoyesj	506	12	03_063	03_063	LS
cord-000248-zueoyesj	506	13	continue	continue	VB
cord-000248-zueoyesj	506	14	to	to	TO
cord-000248-zueoyesj	506	15	appear	appear	VB
cord-000248-zueoyesj	506	16	as	as	IN
cord-000248-zueoyesj	506	17	outliers	outlier	NNS
cord-000248-zueoyesj	506	18	.	.	.
cord-000248-zueoyesj	507	1	In	in	IN
cord-000248-zueoyesj	507	2	addition	addition	NN
cord-000248-zueoyesj	507	3	to	to	IN
cord-000248-zueoyesj	507	4	the	the	DT
cord-000248-zueoyesj	507	5	evidence	evidence	NN
cord-000248-zueoyesj	507	6	,	,	,
cord-000248-zueoyesj	507	7	we	-PRON-	PRP
cord-000248-zueoyesj	507	8	have	have	VBP
cord-000248-zueoyesj	507	9	observed	observe	VBN
cord-000248-zueoyesj	507	10	that	that	IN
cord-000248-zueoyesj	507	11	the	the	DT
cord-000248-zueoyesj	507	12	deletion	deletion	NN
cord-000248-zueoyesj	507	13	of	of	IN
cord-000248-zueoyesj	507	14	these	these	DT
cord-000248-zueoyesj	507	15	two	two	CD
cord-000248-zueoyesj	507	16	samples	sample	NNS
cord-000248-zueoyesj	507	17	did	do	VBD
cord-000248-zueoyesj	507	18	not	not	RB
cord-000248-zueoyesj	507	19	significantly	significantly	RB
cord-000248-zueoyesj	507	20	alter	alter	VB
cord-000248-zueoyesj	507	21	the	the	DT
cord-000248-zueoyesj	507	22	identification	identification	NN
cord-000248-zueoyesj	507	23	of	of	IN
cord-000248-zueoyesj	507	24	biomarkers	biomarker	NNS
cord-000248-zueoyesj	507	25	.	.	.
cord-000248-zueoyesj	508	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	509	1	/journal.pone.0012262.g013	/journal.pone.0012262.g013	.
cord-000248-zueoyesj	509	2	Samples	sample	NNS
cord-000248-zueoyesj	509	3	02_003E	02_003e	CD
cord-000248-zueoyesj	509	4	and	and	CC
cord-000248-zueoyesj	509	5	03_063	03_063	LS
cord-000248-zueoyesj	509	6	seem	seem	VB
cord-000248-zueoyesj	509	7	to	to	TO
cord-000248-zueoyesj	509	8	be	be	VB
cord-000248-zueoyesj	509	9	outliers	outlier	NNS
cord-000248-zueoyesj	509	10	to	to	IN
cord-000248-zueoyesj	509	11	this	this	DT
cord-000248-zueoyesj	509	12	trend	trend	NN
cord-000248-zueoyesj	509	13	,	,	,
cord-000248-zueoyesj	509	14	and	and	CC
cord-000248-zueoyesj	509	15	in	in	IN
cord-000248-zueoyesj	509	16	the	the	DT
cord-000248-zueoyesj	509	17	case	case	NN
cord-000248-zueoyesj	509	18	of	of	IN
cord-000248-zueoyesj	509	19	03_063	03_063	NFP
cord-000248-zueoyesj	509	20	the	the	DT
cord-000248-zueoyesj	509	21	sample	sample	NN
cord-000248-zueoyesj	509	22	is	be	VBZ
cord-000248-zueoyesj	509	23	not	not	RB
cord-000248-zueoyesj	509	24	even	even	RB
cord-000248-zueoyesj	509	25	close	close	JJ
cord-000248-zueoyesj	509	26	to	to	IN
cord-000248-zueoyesj	509	27	a	a	DT
cord-000248-zueoyesj	509	28	hypothetical	hypothetical	JJ
cord-000248-zueoyesj	509	29	linear	linear	JJ
cord-000248-zueoyesj	509	30	fit	fit	NN
cord-000248-zueoyesj	509	31	which	which	WDT
cord-000248-zueoyesj	509	32	seems	seem	VBZ
cord-000248-zueoyesj	509	33	to	to	TO
cord-000248-zueoyesj	509	34	be	be	VB
cord-000248-zueoyesj	509	35	the	the	DT
cord-000248-zueoyesj	509	36	norm	norm	NN
cord-000248-zueoyesj	509	37	for	for	IN
cord-000248-zueoyesj	509	38	all	all	PDT
cord-000248-zueoyesj	509	39	the	the	DT
cord-000248-zueoyesj	509	40	samples	sample	NNS
cord-000248-zueoyesj	509	41	.	.	.
cord-000248-zueoyesj	510	1	Figure	figure	NN
cord-000248-zueoyesj	510	2	13	13	CD
cord-000248-zueoyesj	510	3	will	will	MD
cord-000248-zueoyesj	510	4	provide	provide	VB
cord-000248-zueoyesj	510	5	further	further	JJ
cord-000248-zueoyesj	510	6	evidence	evidence	NN
cord-000248-zueoyesj	510	7	that	that	WDT
cord-000248-zueoyesj	510	8	may	may	MD
cord-000248-zueoyesj	510	9	indicate	indicate	VB
cord-000248-zueoyesj	510	10	that	that	IN
cord-000248-zueoyesj	510	11	these	these	DT
cord-000248-zueoyesj	510	12	two	two	CD
cord-000248-zueoyesj	510	13	samples	sample	NNS
cord-000248-zueoyesj	510	14	are	be	VBP
cord-000248-zueoyesj	510	15	outliers	outlier	NNS
cord-000248-zueoyesj	510	16	or	or	CC
cord-000248-zueoyesj	510	17	not	not	RB
cord-000248-zueoyesj	510	18	to	to	IN
cord-000248-zueoyesj	510	19	the	the	DT
cord-000248-zueoyesj	510	20	overall	overall	JJ
cord-000248-zueoyesj	510	21	trend	trend	NN
cord-000248-zueoyesj	510	22	.	.	.
cord-000248-zueoyesj	511	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	512	1	/journal.pone.0012262.g012	/journal.pone.0012262.g012	NFP
cord-000248-zueoyesj	512	2	with	with	IN
cord-000248-zueoyesj	512	3	the	the	DT
cord-000248-zueoyesj	512	4	dedifferentiation	dedifferentiation	NN
cord-000248-zueoyesj	512	5	process	process	NN
cord-000248-zueoyesj	512	6	,	,	,
cord-000248-zueoyesj	512	7	with	with	IN
cord-000248-zueoyesj	512	8	preoperative	preoperative	JJ
cord-000248-zueoyesj	512	9	PSA	PSA	NNP
cord-000248-zueoyesj	512	10	levels	level	NNS
cord-000248-zueoyesj	512	11	and	and	CC
cord-000248-zueoyesj	512	12	the	the	DT
cord-000248-zueoyesj	512	13	percent	percent	NN
cord-000248-zueoyesj	512	14	of	of	IN
cord-000248-zueoyesj	512	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	512	16	4	4	CD
cord-000248-zueoyesj	512	17	and	and	CC
cord-000248-zueoyesj	512	18	5	5	CD
cord-000248-zueoyesj	512	19	cancers	cancer	NNS
cord-000248-zueoyesj	512	20	[	[	-LRB-
cord-000248-zueoyesj	512	21	338	338	CD
cord-000248-zueoyesj	512	22	]	]	-RRB-
cord-000248-zueoyesj	512	23	.	.	.
cord-000248-zueoyesj	513	1	AMACR	AMACR	NNP
cord-000248-zueoyesj	513	2	,	,	,
cord-000248-zueoyesj	513	3	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	513	4	G2	G2	NNP
cord-000248-zueoyesj	513	5	,	,	,
cord-000248-zueoyesj	513	6	CDK4	CDK4	NNP
cord-000248-zueoyesj	513	7	and	and	CC
cord-000248-zueoyesj	513	8	CDK7	CDK7	NNP
cord-000248-zueoyesj	513	9	.	.	.
cord-000248-zueoyesj	514	1	Other	other	JJ
cord-000248-zueoyesj	514	2	probes	probe	NNS
cord-000248-zueoyesj	514	3	that	that	WDT
cord-000248-zueoyesj	514	4	also	also	RB
cord-000248-zueoyesj	514	5	have	have	VBP
cord-000248-zueoyesj	514	6	high	high	JJ
cord-000248-zueoyesj	514	7	negative	negative	JJ
cord-000248-zueoyesj	514	8	correlations	correlation	NNS
cord-000248-zueoyesj	514	9	with	with	IN
cord-000248-zueoyesj	514	10	the	the	DT
cord-000248-zueoyesj	514	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	514	12	Normalized	Normalized	NNP
cord-000248-zueoyesj	514	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	514	14	correspond	correspond	VBP
cord-000248-zueoyesj	514	15	to	to	IN
cord-000248-zueoyesj	514	16	CCNG2	ccng2	XX
cord-000248-zueoyesj	515	1	(	(	-LRB-
cord-000248-zueoyesj	515	2	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	515	3	G2	G2	NNP
cord-000248-zueoyesj	515	4	)	)	-RRB-
cord-000248-zueoyesj	515	5	CR598707	CR598707	NNP
cord-000248-zueoyesj	515	6	,	,	,
cord-000248-zueoyesj	515	7	CDK4	CDK4	NNP
cord-000248-zueoyesj	515	8	(	(	-LRB-
cord-000248-zueoyesj	515	9	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	515	10	-	-	HYPH
cord-000248-zueoyesj	515	11	dependent	dependent	JJ
cord-000248-zueoyesj	515	12	kinase	kinase	NN
cord-000248-zueoyesj	515	13	4	4	CD
cord-000248-zueoyesj	515	14	)	)	-RRB-
cord-000248-zueoyesj	515	15	,	,	,
cord-000248-zueoyesj	515	16	CDK7	CDK7	NNP
cord-000248-zueoyesj	516	1	(	(	-LRB-
cord-000248-zueoyesj	516	2	Cyclin	Cyclin	NNP
cord-000248-zueoyesj	516	3	-	-	HYPH
cord-000248-zueoyesj	516	4	dependent	dependent	JJ
cord-000248-zueoyesj	516	5	kinase	kinase	NN
cord-000248-zueoyesj	516	6	7	7	CD
cord-000248-zueoyesj	516	7	,	,	,
cord-000248-zueoyesj	516	8	TFIIH	TFIIH	NNP
cord-000248-zueoyesj	516	9	basal	basal	NN
cord-000248-zueoyesj	516	10	transcription	transcription	NN
cord-000248-zueoyesj	516	11	factor	factor	NN
cord-000248-zueoyesj	516	12	complex	complex	NN
cord-000248-zueoyesj	516	13	kinase	kinase	NN
cord-000248-zueoyesj	516	14	subunit	subunit	NN
cord-000248-zueoyesj	516	15	)	)	-RRB-
cord-000248-zueoyesj	516	16	[	[	-LRB-
cord-000248-zueoyesj	516	17	339	339	CD
cord-000248-zueoyesj	516	18	]	]	-RRB-
cord-000248-zueoyesj	516	19	,	,	,
cord-000248-zueoyesj	516	20	and	and	CC
cord-000248-zueoyesj	516	21	AMACR	AMACR	NNP
cord-000248-zueoyesj	516	22	(	(	-LRB-
cord-000248-zueoyesj	516	23	Alpha	alpha	NN
cord-000248-zueoyesj	516	24	-	-	HYPH
cord-000248-zueoyesj	516	25	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	516	26	-	-	HYPH
cord-000248-zueoyesj	516	27	CoA	coa	NN
cord-000248-zueoyesj	516	28	racemase	racemase	NN
cord-000248-zueoyesj	516	29	)	)	-RRB-
cord-000248-zueoyesj	516	30	,	,	,
cord-000248-zueoyesj	516	31	an	an	DT
cord-000248-zueoyesj	516	32	'	'	``
cord-000248-zueoyesj	516	33	'	'	``
cord-000248-zueoyesj	516	34	obscure	obscure	JJ
cord-000248-zueoyesj	516	35	metabolic	metabolic	JJ
cord-000248-zueoyesj	516	36	enzyme	enzyme	NN
cord-000248-zueoyesj	516	37	(	(	-LRB-
cord-000248-zueoyesj	516	38	that	that	DT
cord-000248-zueoyesj	516	39	has	have	VBZ
cord-000248-zueoyesj	516	40	taken	take	VBN
cord-000248-zueoyesj	516	41	)	)	-RRB-
cord-000248-zueoyesj	516	42	centre	centre	NN
cord-000248-zueoyesj	516	43	stage	stage	NN
cord-000248-zueoyesj	516	44	'	'	''
cord-000248-zueoyesj	516	45	'	'	''
cord-000248-zueoyesj	516	46	[	[	-LRB-
cord-000248-zueoyesj	516	47	340	340	CD
cord-000248-zueoyesj	516	48	]	]	-RRB-
cord-000248-zueoyesj	516	49	as	as	IN
cord-000248-zueoyesj	516	50	judged	judge	VBN
cord-000248-zueoyesj	516	51	by	by	IN
cord-000248-zueoyesj	516	52	the	the	DT
cord-000248-zueoyesj	516	53	extraordinary	extraordinary	JJ
cord-000248-zueoyesj	516	54	convergence	convergence	NN
cord-000248-zueoyesj	516	55	to	to	IN
cord-000248-zueoyesj	516	56	this	this	DT
cord-000248-zueoyesj	516	57	biomarker	biomarker	NN
cord-000248-zueoyesj	516	58	in	in	IN
cord-000248-zueoyesj	516	59	prostate	prostate	NN
cord-000248-zueoyesj	516	60	.	.	.
cord-000248-zueoyesj	517	1	We	-PRON-	PRP
cord-000248-zueoyesj	517	2	believe	believe	VBP
cord-000248-zueoyesj	517	3	that	that	IN
cord-000248-zueoyesj	517	4	our	-PRON-	PRP$
cord-000248-zueoyesj	517	5	result	result	NN
cord-000248-zueoyesj	517	6	is	be	VBZ
cord-000248-zueoyesj	517	7	an	an	DT
cord-000248-zueoyesj	517	8	important	important	JJ
cord-000248-zueoyesj	517	9	finding	finding	NN
cord-000248-zueoyesj	517	10	.	.	.
cord-000248-zueoyesj	518	1	AMACR	AMACR	NNP
cord-000248-zueoyesj	518	2	was	be	VBD
cord-000248-zueoyesj	518	3	not	not	RB
cord-000248-zueoyesj	518	4	judged	judge	VBN
cord-000248-zueoyesj	518	5	of	of	IN
cord-000248-zueoyesj	518	6	importance	importance	NN
cord-000248-zueoyesj	518	7	according	accord	VBG
cord-000248-zueoyesj	518	8	to	to	IN
cord-000248-zueoyesj	518	9	the	the	DT
cord-000248-zueoyesj	518	10	methodology	methodology	NN
cord-000248-zueoyesj	518	11	used	use	VBN
cord-000248-zueoyesj	518	12	in	in	IN
cord-000248-zueoyesj	518	13	[	[	-LRB-
cord-000248-zueoyesj	518	14	332	332	CD
cord-000248-zueoyesj	518	15	]	]	-RRB-
cord-000248-zueoyesj	518	16	and	and	CC
cord-000248-zueoyesj	518	17	it	-PRON-	PRP
cord-000248-zueoyesj	518	18	was	be	VBD
cord-000248-zueoyesj	518	19	barely	barely	RB
cord-000248-zueoyesj	518	20	cited	cite	VBN
cord-000248-zueoyesj	518	21	in	in	IN
cord-000248-zueoyesj	518	22	that	that	DT
cord-000248-zueoyesj	518	23	manuscript	manuscript	NN
cord-000248-zueoyesj	518	24	.	.	.
cord-000248-zueoyesj	519	1	Here	here	RB
cord-000248-zueoyesj	519	2	we	-PRON-	PRP
cord-000248-zueoyesj	519	3	present	present	VBP
cord-000248-zueoyesj	519	4	results	result	NNS
cord-000248-zueoyesj	519	5	,	,	,
cord-000248-zueoyesj	519	6	from	from	IN
cord-000248-zueoyesj	519	7	an	an	DT
cord-000248-zueoyesj	519	8	unifying	unify	VBG
cord-000248-zueoyesj	519	9	biological	biological	JJ
cord-000248-zueoyesj	519	10	and	and	CC
cord-000248-zueoyesj	519	11	informational	informational	JJ
cord-000248-zueoyesj	519	12	principle	principle	NN
cord-000248-zueoyesj	519	13	,	,	,
cord-000248-zueoyesj	519	14	which	which	WDT
cord-000248-zueoyesj	519	15	allows	allow	VBZ
cord-000248-zueoyesj	519	16	(	(	-LRB-
cord-000248-zueoyesj	519	17	using	use	VBG
cord-000248-zueoyesj	519	18	Ref	Ref	NNP
cord-000248-zueoyesj	519	19	.	.	.
cord-000248-zueoyesj	520	1	[	[	-LRB-
cord-000248-zueoyesj	520	2	332	332	CD
cord-000248-zueoyesj	520	3	]	]	-RRB-
cord-000248-zueoyesj	520	4	's	's	POS
cord-000248-zueoyesj	520	5	own	own	JJ
cord-000248-zueoyesj	520	6	data	datum	NNS
cord-000248-zueoyesj	520	7	)	)	-RRB-
cord-000248-zueoyesj	521	1	the	the	DT
cord-000248-zueoyesj	521	2	identification	identification	NN
cord-000248-zueoyesj	521	3	of	of	IN
cord-000248-zueoyesj	521	4	the	the	DT
cord-000248-zueoyesj	521	5	most	most	RBS
cord-000248-zueoyesj	521	6	central	central	JJ
cord-000248-zueoyesj	521	7	current	current	JJ
cord-000248-zueoyesj	521	8	biomarker	biomarker	NN
cord-000248-zueoyesj	521	9	with	with	IN
cord-000248-zueoyesj	521	10	a	a	DT
cord-000248-zueoyesj	521	11	truly	truly	RB
cord-000248-zueoyesj	521	12	compelling	compelling	JJ
cord-000248-zueoyesj	521	13	body	body	NN
cord-000248-zueoyesj	521	14	of	of	IN
cord-000248-zueoyesj	521	15	support	support	NN
cord-000248-zueoyesj	521	16	in	in	IN
cord-000248-zueoyesj	521	17	independent	independent	JJ
cord-000248-zueoyesj	521	18	studies	study	NNS
cord-000248-zueoyesj	521	19	[	[	-LRB-
cord-000248-zueoyesj	521	20	[	[	-LRB-
cord-000248-zueoyesj	521	21	490	490	CD
cord-000248-zueoyesj	521	22	,	,	,
cord-000248-zueoyesj	521	23	491	491	CD
cord-000248-zueoyesj	521	24	]	]	-RRB-
cord-000248-zueoyesj	521	25	.	.	.
cord-000248-zueoyesj	522	1	Knockdown	knockdown	NN
cord-000248-zueoyesj	522	2	of	of	IN
cord-000248-zueoyesj	522	3	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	522	4	results	result	NNS
cord-000248-zueoyesj	522	5	in	in	IN
cord-000248-zueoyesj	522	6	the	the	DT
cord-000248-zueoyesj	522	7	accumulation	accumulation	NN
cord-000248-zueoyesj	522	8	of	of	IN
cord-000248-zueoyesj	522	9	multinucleated	multinucleated	JJ
cord-000248-zueoyesj	522	10	cells	cell	NNS
cord-000248-zueoyesj	522	11	,	,	,
cord-000248-zueoyesj	522	12	indicating	indicate	VBG
cord-000248-zueoyesj	522	13	that	that	IN
cord-000248-zueoyesj	522	14	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	522	15	regulates	regulate	VBZ
cord-000248-zueoyesj	522	16	gene	gene	NN
cord-000248-zueoyesj	522	17	expression	expression	NN
cord-000248-zueoyesj	522	18	of	of	IN
cord-000248-zueoyesj	522	19	an	an	DT
cord-000248-zueoyesj	522	20	orderly	orderly	JJ
cord-000248-zueoyesj	522	21	progression	progression	NN
cord-000248-zueoyesj	522	22	during	during	IN
cord-000248-zueoyesj	522	23	mitosis	mitosis	NN
cord-000248-zueoyesj	522	24	[	[	-LRB-
cord-000248-zueoyesj	522	25	492	492	CD
cord-000248-zueoyesj	522	26	]	]	-RRB-
cord-000248-zueoyesj	522	27	,	,	,
cord-000248-zueoyesj	522	28	preserving	preserve	VBG
cord-000248-zueoyesj	522	29	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	522	30	stability	stability	NN
cord-000248-zueoyesj	522	31	[	[	-LRB-
cord-000248-zueoyesj	522	32	490	490	CD
cord-000248-zueoyesj	522	33	]	]	-RRB-
cord-000248-zueoyesj	522	34	.	.	.
cord-000248-zueoyesj	523	1	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	523	2	showed	show	VBD
cord-000248-zueoyesj	523	3	decreased	decreased	JJ
cord-000248-zueoyesj	523	4	expression	expression	NN
cord-000248-zueoyesj	523	5	in	in	IN
cord-000248-zueoyesj	523	6	a	a	DT
cord-000248-zueoyesj	523	7	study	study	NN
cord-000248-zueoyesj	523	8	involving	involve	VBG
cord-000248-zueoyesj	523	9	immortalized	immortalize	VBN
cord-000248-zueoyesj	523	10	prostate	prostate	NN
cord-000248-zueoyesj	523	11	epithelial	epithelial	JJ
cord-000248-zueoyesj	523	12	cells	cell	NNS
cord-000248-zueoyesj	523	13	before	before	IN
cord-000248-zueoyesj	523	14	and	and	CC
cord-000248-zueoyesj	523	15	after	after	IN
cord-000248-zueoyesj	523	16	their	-PRON-	PRP$
cord-000248-zueoyesj	523	17	conversion	conversion	NN
cord-000248-zueoyesj	523	18	to	to	IN
cord-000248-zueoyesj	523	19	tumorigenicity	tumorigenicity	NN
cord-000248-zueoyesj	523	20	[	[	-LRB-
cord-000248-zueoyesj	523	21	493	493	CD
cord-000248-zueoyesj	523	22	]	]	-RRB-
cord-000248-zueoyesj	523	23	.	.	.
cord-000248-zueoyesj	524	1	Lack	lack	NN
cord-000248-zueoyesj	524	2	of	of	IN
cord-000248-zueoyesj	524	3	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	524	4	function	function	NN
cord-000248-zueoyesj	524	5	may	may	MD
cord-000248-zueoyesj	524	6	impair	impair	VB
cord-000248-zueoyesj	524	7	activation	activation	NN
cord-000248-zueoyesj	524	8	of	of	IN
cord-000248-zueoyesj	524	9	STAT3	STAT3	NNP
cord-000248-zueoyesj	524	10	[	[	-LRB-
cord-000248-zueoyesj	524	11	494	494	CD
cord-000248-zueoyesj	524	12	]	]	-RRB-
cord-000248-zueoyesj	524	13	.	.	.
cord-000248-zueoyesj	525	1	Inactivation	inactivation	NN
cord-000248-zueoyesj	525	2	of	of	IN
cord-000248-zueoyesj	525	3	TP53	TP53	NNP
cord-000248-zueoyesj	525	4	by	by	IN
cord-000248-zueoyesj	525	5	somatic	somatic	JJ
cord-000248-zueoyesj	525	6	mutations	mutation	NNS
cord-000248-zueoyesj	525	7	is	be	VBZ
cord-000248-zueoyesj	525	8	also	also	RB
cord-000248-zueoyesj	525	9	associated	associate	VBN
cord-000248-zueoyesj	525	10	to	to	IN
cord-000248-zueoyesj	525	11	the	the	DT
cord-000248-zueoyesj	525	12	panel	panel	NN
cord-000248-zueoyesj	525	13	of	of	IN
cord-000248-zueoyesj	525	14	disruptions	disruption	NNS
cord-000248-zueoyesj	525	15	which	which	WDT
cord-000248-zueoyesj	525	16	are	be	VBP
cord-000248-zueoyesj	525	17	common	common	JJ
cord-000248-zueoyesj	525	18	for	for	IN
cord-000248-zueoyesj	525	19	this	this	DT
cord-000248-zueoyesj	525	20	'	'	''
cord-000248-zueoyesj	525	21	'	'	``
cord-000248-zueoyesj	525	22	tumor	tumor	NN
cord-000248-zueoyesj	525	23	suppressor	suppressor	NN
cord-000248-zueoyesj	525	24	'	'	''
cord-000248-zueoyesj	525	25	'	'	''
cord-000248-zueoyesj	525	26	[	[	-LRB-
cord-000248-zueoyesj	525	27	113	113	CD
cord-000248-zueoyesj	525	28	]	]	-RRB-
cord-000248-zueoyesj	525	29	.	.	.
cord-000248-zueoyesj	526	1	One	one	CD
cord-000248-zueoyesj	526	2	possible	possible	JJ
cord-000248-zueoyesj	526	3	mechanism	mechanism	NN
cord-000248-zueoyesj	526	4	for	for	IN
cord-000248-zueoyesj	526	5	gene	gene	NN
cord-000248-zueoyesj	526	6	silencing	silencing	NN
cord-000248-zueoyesj	526	7	is	be	VBZ
cord-000248-zueoyesj	526	8	CpG	CpG	NNP
cord-000248-zueoyesj	526	9	island	island	NNP
cord-000248-zueoyesj	526	10	methylation	methylation	NNP
cord-000248-zueoyesj	526	11	.	.	.
cord-000248-zueoyesj	527	1	Rabiau	Rabiau	NNP
cord-000248-zueoyesj	527	2	et	et	IN
cord-000248-zueoyesj	527	3	al.show	al.show	NN
cord-000248-zueoyesj	527	4	in	in	IN
cord-000248-zueoyesj	527	5	[	[	-LRB-
cord-000248-zueoyesj	527	6	495	495	CD
cord-000248-zueoyesj	527	7	]	]	-RRB-
cord-000248-zueoyesj	527	8	that	that	IN
cord-000248-zueoyesj	527	9	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	527	10	,	,	,
cord-000248-zueoyesj	527	11	RASSF1	RASSF1	NNS
cord-000248-zueoyesj	527	12	,	,	,
cord-000248-zueoyesj	527	13	GSTP1	GSTP1	NNP
cord-000248-zueoyesj	527	14	and	and	CC
cord-000248-zueoyesj	527	15	EPHB2	ephb2	NN
cord-000248-zueoyesj	528	1	promoter	promoter	NN
cord-000248-zueoyesj	528	2	methylation	methylation	NNP
cord-000248-zueoyesj	528	3	is	be	VBZ
cord-000248-zueoyesj	528	4	common	common	JJ
cord-000248-zueoyesj	528	5	in	in	IN
cord-000248-zueoyesj	528	6	prostate	prostate	NN
cord-000248-zueoyesj	528	7	biopsy	biopsy	NN
cord-000248-zueoyesj	528	8	samples	sample	NNS
cord-000248-zueoyesj	528	9	.	.	.
cord-000248-zueoyesj	529	1	Mannicia	Mannicia	NNP
cord-000248-zueoyesj	529	2	et	et	NNP
cord-000248-zueoyesj	529	3	al	al	NNP
cord-000248-zueoyesj	529	4	.	.	.
cord-000248-zueoyesj	530	1	suggest	suggest	VBP
cord-000248-zueoyesj	530	2	that	that	IN
cord-000248-zueoyesj	530	3	the	the	DT
cord-000248-zueoyesj	530	4	mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	530	5	localization	localization	NN
cord-000248-zueoyesj	530	6	of	of	IN
cord-000248-zueoyesj	530	7	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	530	8	proteins	protein	NNS
cord-000248-zueoyesj	530	9	may	may	MD
cord-000248-zueoyesj	530	10	be	be	VB
cord-000248-zueoyesj	530	11	a	a	DT
cord-000248-zueoyesj	530	12	significant	significant	JJ
cord-000248-zueoyesj	530	13	factor	factor	NN
cord-000248-zueoyesj	530	14	in	in	IN
cord-000248-zueoyesj	530	15	regulating	regulate	VBG
cord-000248-zueoyesj	530	16	the	the	DT
cord-000248-zueoyesj	530	17	mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	530	18	DNA	dna	NN
cord-000248-zueoyesj	530	19	damage	damage	NN
cord-000248-zueoyesj	530	20	[	[	-LRB-
cord-000248-zueoyesj	530	21	5	5	CD
cord-000248-zueoyesj	530	22	]	]	-RRB-
cord-000248-zueoyesj	530	23	.	.	.
cord-000248-zueoyesj	531	1	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	531	2	-(Polypyrimidine	-(polypyrimidine	NN
cord-000248-zueoyesj	531	3	tract	tract	NN
cord-000248-zueoyesj	531	4	-	-	HYPH
cord-000248-zueoyesj	531	5	binding	bind	VBG
cord-000248-zueoyesj	531	6	protein	protein	NN
cord-000248-zueoyesj	531	7	-	-	HYPH
cord-000248-zueoyesj	531	8	associated	associate	VBN
cord-000248-zueoyesj	531	9	splicing	splicing	NN
cord-000248-zueoyesj	531	10	factor	factor	NN
cord-000248-zueoyesj	531	11	)	)	-RRB-
cord-000248-zueoyesj	531	12	.	.	.
cord-000248-zueoyesj	532	1	The	the	DT
cord-000248-zueoyesj	532	2	most	most	RBS
cord-000248-zueoyesj	532	3	positively	positively	RB
cord-000248-zueoyesj	532	4	correlated	correlate	VBN
cord-000248-zueoyesj	532	5	gene	gene	NN
cord-000248-zueoyesj	532	6	with	with	IN
cord-000248-zueoyesj	532	7	the	the	DT
cord-000248-zueoyesj	532	8	loss	loss	NN
cord-000248-zueoyesj	532	9	of	of	IN
cord-000248-zueoyesj	532	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	532	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	532	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	532	13	is	be	VBZ
cord-000248-zueoyesj	532	14	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	532	15	/	/	SYM
cord-000248-zueoyesj	532	16	PSF	PSF	NNP
cord-000248-zueoyesj	532	17	(	(	-LRB-
cord-000248-zueoyesj	532	18	Polypyrimidine	polypyrimidine	JJ
cord-000248-zueoyesj	532	19	tract	tract	NN
cord-000248-zueoyesj	532	20	-	-	HYPH
cord-000248-zueoyesj	532	21	binding	bind	VBG
cord-000248-zueoyesj	532	22	protein	protein	NN
cord-000248-zueoyesj	532	23	-	-	HYPH
cord-000248-zueoyesj	532	24	associated	associate	VBN
cord-000248-zueoyesj	532	25	splicing	splicing	NN
cord-000248-zueoyesj	532	26	factor	factor	NN
cord-000248-zueoyesj	532	27	)	)	-RRB-
cord-000248-zueoyesj	532	28	(	(	-LRB-
cord-000248-zueoyesj	532	29	Spearman	Spearman	NNP
cord-000248-zueoyesj	532	30	correlation	correlation	NN
cord-000248-zueoyesj	532	31	of	of	IN
cord-000248-zueoyesj	532	32	0.7902	0.7902	CD
cord-000248-zueoyesj	532	33	)	)	-RRB-
cord-000248-zueoyesj	532	34	,	,	,
cord-000248-zueoyesj	532	35	a	a	DT
cord-000248-zueoyesj	532	36	multifaceted	multifaceted	JJ
cord-000248-zueoyesj	532	37	nuclear	nuclear	JJ
cord-000248-zueoyesj	532	38	factor	factor	NN
cord-000248-zueoyesj	532	39	[	[	-LRB-
cord-000248-zueoyesj	532	40	496	496	CD
cord-000248-zueoyesj	532	41	,	,	,
cord-000248-zueoyesj	532	42	497	497	CD
cord-000248-zueoyesj	532	43	]	]	-RRB-
cord-000248-zueoyesj	532	44	which	which	WDT
cord-000248-zueoyesj	532	45	is	be	VBZ
cord-000248-zueoyesj	532	46	also	also	RB
cord-000248-zueoyesj	532	47	a	a	DT
cord-000248-zueoyesj	532	48	putative	putative	JJ
cord-000248-zueoyesj	532	49	regulator	regulator	NN
cord-000248-zueoyesj	532	50	of	of	IN
cord-000248-zueoyesj	532	51	growth	growth	NN
cord-000248-zueoyesj	532	52	factor	factor	NN
cord-000248-zueoyesj	532	53	-	-	HYPH
cord-000248-zueoyesj	532	54	stimulated	stimulate	VBN
cord-000248-zueoyesj	532	55	gene	gene	NN
cord-000248-zueoyesj	532	56	expression	expression	NN
cord-000248-zueoyesj	532	57	[	[	-LRB-
cord-000248-zueoyesj	532	58	498	498	CD
cord-000248-zueoyesj	532	59	]	]	-RRB-
cord-000248-zueoyesj	532	60	.	.	.
cord-000248-zueoyesj	533	1	This	this	DT
cord-000248-zueoyesj	533	2	is	be	VBZ
cord-000248-zueoyesj	533	3	extremely	extremely	RB
cord-000248-zueoyesj	533	4	interesting	interesting	JJ
cord-000248-zueoyesj	533	5	as	as	IN
cord-000248-zueoyesj	533	6	it	-PRON-	PRP
cord-000248-zueoyesj	533	7	has	have	VBZ
cord-000248-zueoyesj	533	8	been	be	VBN
cord-000248-zueoyesj	533	9	recently	recently	RB
cord-000248-zueoyesj	533	10	shown	show	VBN
cord-000248-zueoyesj	533	11	that	that	IN
cord-000248-zueoyesj	533	12	the	the	DT
cord-000248-zueoyesj	533	13	AR	AR	NNP
cord-000248-zueoyesj	533	14	/	/	SYM
cord-000248-zueoyesj	533	15	PSF	PSF	NNP
cord-000248-zueoyesj	533	16	complex	complex	NN
cord-000248-zueoyesj	533	17	interacts	interact	VBZ
cord-000248-zueoyesj	533	18	with	with	IN
cord-000248-zueoyesj	533	19	human	human	JJ
cord-000248-zueoyesj	533	20	PSA	PSA	NNP
cord-000248-zueoyesj	533	21	gene	gene	NN
cord-000248-zueoyesj	533	22	and	and	CC
cord-000248-zueoyesj	533	23	that	that	IN
cord-000248-zueoyesj	533	24	PSF	PSF	NNP
cord-000248-zueoyesj	533	25	inhibits	inhibit	VBZ
cord-000248-zueoyesj	533	26	AR	AR	NNP
cord-000248-zueoyesj	533	27	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	533	28	activity	activity	NN
cord-000248-zueoyesj	533	29	[	[	-LRB-
cord-000248-zueoyesj	533	30	499	499	CD
cord-000248-zueoyesj	533	31	]	]	-RRB-
cord-000248-zueoyesj	533	32	.	.	.
cord-000248-zueoyesj	534	1	The	the	DT
cord-000248-zueoyesj	534	2	loss	loss	NN
cord-000248-zueoyesj	534	3	of	of	IN
cord-000248-zueoyesj	534	4	expression	expression	NN
cord-000248-zueoyesj	534	5	of	of	IN
cord-000248-zueoyesj	534	6	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	534	7	and	and	CC
cord-000248-zueoyesj	534	8	other	other	JJ
cord-000248-zueoyesj	534	9	proteins	protein	NNS
cord-000248-zueoyesj	534	10	that	that	WDT
cord-000248-zueoyesj	534	11	together	together	RB
cord-000248-zueoyesj	534	12	regulate	regulate	VBP
cord-000248-zueoyesj	534	13	androgen	androgen	NN
cord-000248-zueoyesj	534	14	receptor	receptor	NN
cord-000248-zueoyesj	534	15	-	-	HYPH
cord-000248-zueoyesj	534	16	mediated	mediate	VBN
cord-000248-zueoyesj	534	17	gene	gene	NN
cord-000248-zueoyesj	534	18	transcription	transcription	NN
cord-000248-zueoyesj	534	19	[	[	-LRB-
cord-000248-zueoyesj	534	20	500	500	CD
cord-000248-zueoyesj	534	21	]	]	-RRB-
cord-000248-zueoyesj	535	1	(	(	-LRB-
cord-000248-zueoyesj	535	2	see	see	VB
cord-000248-zueoyesj	535	3	also	also	RB
cord-000248-zueoyesj	535	4	[	[	-LRB-
cord-000248-zueoyesj	535	5	501	501	CD
cord-000248-zueoyesj	535	6	,	,	,
cord-000248-zueoyesj	535	7	502	502	CD
cord-000248-zueoyesj	535	8	]	]	-RRB-
cord-000248-zueoyesj	535	9	)	)	-RRB-
cord-000248-zueoyesj	535	10	may	may	MD
cord-000248-zueoyesj	535	11	indicate	indicate	VB
cord-000248-zueoyesj	535	12	they	-PRON-	PRP
cord-000248-zueoyesj	535	13	have	have	VBP
cord-000248-zueoyesj	535	14	a	a	DT
cord-000248-zueoyesj	535	15	role	role	NN
cord-000248-zueoyesj	535	16	not	not	RB
cord-000248-zueoyesj	535	17	only	only	RB
cord-000248-zueoyesj	535	18	as	as	IN
cord-000248-zueoyesj	535	19	a	a	DT
cord-000248-zueoyesj	535	20	biomarker	biomarker	NN
cord-000248-zueoyesj	535	21	of	of	IN
cord-000248-zueoyesj	535	22	the	the	DT
cord-000248-zueoyesj	535	23	progression	progression	NN
cord-000248-zueoyesj	535	24	and	and	CC
cord-000248-zueoyesj	535	25	well	well	UH
cord-000248-zueoyesj	535	26	as	as	IN
cord-000248-zueoyesj	535	27	transitions	transition	NNS
cord-000248-zueoyesj	535	28	of	of	IN
cord-000248-zueoyesj	535	29	the	the	DT
cord-000248-zueoyesj	535	30	disease	disease	NN
cord-000248-zueoyesj	535	31	to	to	IN
cord-000248-zueoyesj	535	32	androgen	androgen	NN
cord-000248-zueoyesj	535	33	independence	independence	NN
cord-000248-zueoyesj	535	34	.	.	.
cord-000248-zueoyesj	536	1	In	in	IN
cord-000248-zueoyesj	536	2	a	a	DT
cord-000248-zueoyesj	536	3	study	study	NN
cord-000248-zueoyesj	536	4	of	of	IN
cord-000248-zueoyesj	536	5	human	human	JJ
cord-000248-zueoyesj	536	6	labor	labor	NN
cord-000248-zueoyesj	536	7	,	,	,
cord-000248-zueoyesj	536	8	Dong	Dong	NNP
cord-000248-zueoyesj	536	9	et	et	FW
cord-000248-zueoyesj	536	10	al	al	NNP
cord-000248-zueoyesj	536	11	.	.	NNP
cord-000248-zueoyesj	536	12	,	,	,
cord-000248-zueoyesj	536	13	also	also	RB
cord-000248-zueoyesj	536	14	showed	show	VBD
cord-000248-zueoyesj	536	15	that	that	IN
cord-000248-zueoyesj	536	16	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	536	17	acts	act	VBZ
cord-000248-zueoyesj	536	18	as	as	IN
cord-000248-zueoyesj	536	19	a	a	DT
cord-000248-zueoyesj	536	20	Progesterone	Progesterone	NNP
cord-000248-zueoyesj	536	21	Receptor	receptor	NN
cord-000248-zueoyesj	536	22	corepressor	corepressor	NN
cord-000248-zueoyesj	536	23	,	,	,
cord-000248-zueoyesj	536	24	thus	thus	RB
cord-000248-zueoyesj	536	25	putatively	putatively	RB
cord-000248-zueoyesj	536	26	contributing	contribute	VBG
cord-000248-zueoyesj	536	27	to	to	IN
cord-000248-zueoyesj	536	28	the	the	DT
cord-000248-zueoyesj	536	29	functional	functional	JJ
cord-000248-zueoyesj	536	30	withdrawal	withdrawal	NN
cord-000248-zueoyesj	536	31	of	of	IN
cord-000248-zueoyesj	536	32	progesterone	progesterone	NN
cord-000248-zueoyesj	536	33	[	[	-LRB-
cord-000248-zueoyesj	536	34	503	503	CD
cord-000248-zueoyesj	536	35	]	]	-RRB-
cord-000248-zueoyesj	536	36	.	.	.
cord-000248-zueoyesj	537	1	We	-PRON-	PRP
cord-000248-zueoyesj	537	2	will	will	MD
cord-000248-zueoyesj	537	3	return	return	VB
cord-000248-zueoyesj	537	4	to	to	IN
cord-000248-zueoyesj	537	5	this	this	DT
cord-000248-zueoyesj	537	6	particular	particular	JJ
cord-000248-zueoyesj	537	7	gene	gene	NN
cord-000248-zueoyesj	537	8	later	later	RB
cord-000248-zueoyesj	537	9	on	on	IN
cord-000248-zueoyesj	537	10	the	the	DT
cord-000248-zueoyesj	537	11	'	'	``
cord-000248-zueoyesj	537	12	Discussion	discussion	NN
cord-000248-zueoyesj	537	13	'	'	''
cord-000248-zueoyesj	537	14	section	section	NN
cord-000248-zueoyesj	537	15	as	as	IN
cord-000248-zueoyesj	537	16	new	new	JJ
cord-000248-zueoyesj	537	17	evidence	evidence	NN
cord-000248-zueoyesj	537	18	of	of	IN
cord-000248-zueoyesj	537	19	its	-PRON-	PRP$
cord-000248-zueoyesj	537	20	role	role	NN
cord-000248-zueoyesj	537	21	in	in	IN
cord-000248-zueoyesj	537	22	nuclear	nuclear	JJ
cord-000248-zueoyesj	537	23	organization	organization	NN
cord-000248-zueoyesj	537	24	has	have	VBZ
cord-000248-zueoyesj	537	25	been	be	VBN
cord-000248-zueoyesj	537	26	documented	document	VBN
cord-000248-zueoyesj	537	27	.	.	.
cord-000248-zueoyesj	538	1	CD40	CD40	NNP
cord-000248-zueoyesj	538	2	-(TNFRSF5	-(TNFRSF5	NNP
cord-000248-zueoyesj	538	3	,	,	,
cord-000248-zueoyesj	538	4	B	b	NN
cord-000248-zueoyesj	538	5	-	-	HYPH
cord-000248-zueoyesj	538	6	cell	cell	NN
cord-000248-zueoyesj	538	7	surface	surface	NN
cord-000248-zueoyesj	538	8	antigen	antigen	NN
cord-000248-zueoyesj	538	9	CD40	CD40	NNP
cord-000248-zueoyesj	538	10	)	)	-RRB-
cord-000248-zueoyesj	538	11	.	.	.
cord-000248-zueoyesj	539	1	The	the	DT
cord-000248-zueoyesj	539	2	loss	loss	NN
cord-000248-zueoyesj	539	3	of	of	IN
cord-000248-zueoyesj	539	4	Normalized	Normalized	NNP
cord-000248-zueoyesj	539	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	539	6	Entropy	Entropy	NNP
cord-000248-zueoyesj	539	7	gives	give	VBZ
cord-000248-zueoyesj	539	8	us	-PRON-	PRP
cord-000248-zueoyesj	539	9	several	several	JJ
cord-000248-zueoyesj	539	10	markers	marker	NNS
cord-000248-zueoyesj	539	11	that	that	WDT
cord-000248-zueoyesj	539	12	indicate	indicate	VBP
cord-000248-zueoyesj	539	13	a	a	DT
cord-000248-zueoyesj	539	14	de	de	NN
cord-000248-zueoyesj	539	15	-	-	NN
cord-000248-zueoyesj	539	16	differentiation	differentiation	NN
cord-000248-zueoyesj	539	17	from	from	IN
cord-000248-zueoyesj	539	18	a	a	DT
cord-000248-zueoyesj	539	19	epithelial	epithelial	JJ
cord-000248-zueoyesj	539	20	basal	basal	NN
cord-000248-zueoyesj	539	21	phenotype	phenotype	NN
cord-000248-zueoyesj	539	22	and	and	CC
cord-000248-zueoyesj	539	23	an	an	DT
cord-000248-zueoyesj	539	24	increasing	increase	VBG
cord-000248-zueoyesj	539	25	loss	loss	NN
cord-000248-zueoyesj	539	26	of	of	IN
cord-000248-zueoyesj	539	27	control	control	NN
cord-000248-zueoyesj	539	28	of	of	IN
cord-000248-zueoyesj	539	29	cell	cell	NN
cord-000248-zueoyesj	539	30	cycle	cycle	NN
cord-000248-zueoyesj	539	31	regulation	regulation	NN
cord-000248-zueoyesj	539	32	(	(	-LRB-
cord-000248-zueoyesj	539	33	due	due	IN
cord-000248-zueoyesj	539	34	to	to	IN
cord-000248-zueoyesj	539	35	uncoordinated	uncoordinated	JJ
cord-000248-zueoyesj	539	36	upregulation	upregulation	NN
cord-000248-zueoyesj	539	37	of	of	IN
cord-000248-zueoyesj	539	38	CDK4	CDK4	NNP
cord-000248-zueoyesj	539	39	,	,	,
cord-000248-zueoyesj	539	40	CDK7	CDK7	NNP
cord-000248-zueoyesj	539	41	,	,	,
cord-000248-zueoyesj	539	42	CCNG2	ccng2	IN
cord-000248-zueoyesj	539	43	with	with	IN
cord-000248-zueoyesj	539	44	their	-PRON-	PRP$
cord-000248-zueoyesj	539	45	functional	functional	JJ
cord-000248-zueoyesj	539	46	partners	partner	NNS
cord-000248-zueoyesj	539	47	)	)	-RRB-
cord-000248-zueoyesj	539	48	.	.	.
cord-000248-zueoyesj	540	1	This	this	DT
cord-000248-zueoyesj	540	2	poses	pose	VBZ
cord-000248-zueoyesj	540	3	the	the	DT
cord-000248-zueoyesj	540	4	question	question	NN
cord-000248-zueoyesj	540	5	:	:	:
cord-000248-zueoyesj	540	6	What	what	WP
cord-000248-zueoyesj	540	7	can	can	MD
cord-000248-zueoyesj	540	8	we	-PRON-	PRP
cord-000248-zueoyesj	540	9	observe	observe	VB
cord-000248-zueoyesj	540	10	while	while	IN
cord-000248-zueoyesj	540	11	looking	look	VBG
cord-000248-zueoyesj	540	12	at	at	IN
cord-000248-zueoyesj	540	13	the	the	DT
cord-000248-zueoyesj	540	14	genes	gene	NNS
cord-000248-zueoyesj	540	15	that	that	WDT
cord-000248-zueoyesj	540	16	most	most	RBS
cord-000248-zueoyesj	540	17	positively	positively	RB
cord-000248-zueoyesj	540	18	correlate	correlate	VBP
cord-000248-zueoyesj	540	19	with	with	IN
cord-000248-zueoyesj	540	20	the	the	DT
cord-000248-zueoyesj	540	21	loss	loss	NN
cord-000248-zueoyesj	540	22	of	of	IN
cord-000248-zueoyesj	540	23	Normalized	Normalized	NNP
cord-000248-zueoyesj	540	24	Shannon	Shannon	NNP
cord-000248-zueoyesj	540	25	Entropy	Entropy	NNP
cord-000248-zueoyesj	540	26	?	?	.
cord-000248-zueoyesj	541	1	We	-PRON-	PRP
cord-000248-zueoyesj	541	2	observe	observe	VBP
cord-000248-zueoyesj	541	3	,	,	,
cord-000248-zueoyesj	541	4	second	second	RB
cord-000248-zueoyesj	541	5	on	on	IN
cord-000248-zueoyesj	541	6	the	the	DT
cord-000248-zueoyesj	541	7	ranking	ranking	NN
cord-000248-zueoyesj	541	8	of	of	IN
cord-000248-zueoyesj	541	9	all	all	DT
cord-000248-zueoyesj	541	10	samples	sample	NNS
cord-000248-zueoyesj	541	11	,	,	,
cord-000248-zueoyesj	541	12	a	a	DT
cord-000248-zueoyesj	541	13	probe	probe	NN
cord-000248-zueoyesj	541	14	for	for	IN
cord-000248-zueoyesj	541	15	CD40	CD40	NNP
cord-000248-zueoyesj	541	16	(	(	-LRB-
cord-000248-zueoyesj	541	17	TNFRSF5	tnfrsf5	XX
cord-000248-zueoyesj	541	18	,	,	,
cord-000248-zueoyesj	541	19	B	b	NN
cord-000248-zueoyesj	541	20	-	-	HYPH
cord-000248-zueoyesj	541	21	cell	cell	NN
cord-000248-zueoyesj	541	22	surface	surface	NN
cord-000248-zueoyesj	541	23	antigen	antigen	NN
cord-000248-zueoyesj	541	24	CD40	CD40	NNP
cord-000248-zueoyesj	541	25	)	)	-RRB-
cord-000248-zueoyesj	541	26	,	,	,
cord-000248-zueoyesj	541	27	BX381481	BX381481	NNP
cord-000248-zueoyesj	541	28	with	with	IN
cord-000248-zueoyesj	541	29	a	a	DT
cord-000248-zueoyesj	541	30	Spearman	Spearman	NNP
cord-000248-zueoyesj	541	31	correlation	correlation	NN
cord-000248-zueoyesj	541	32	of	of	IN
cord-000248-zueoyesj	541	33	0.7616	0.7616	CD
cord-000248-zueoyesj	541	34	.	.	.
cord-000248-zueoyesj	542	1	Loss	loss	NN
cord-000248-zueoyesj	542	2	of	of	IN
cord-000248-zueoyesj	542	3	CD40	CD40	NNP
cord-000248-zueoyesj	542	4	expression	expression	NN
cord-000248-zueoyesj	542	5	has	have	VBZ
cord-000248-zueoyesj	542	6	been	be	VBN
cord-000248-zueoyesj	542	7	previously	previously	RB
cord-000248-zueoyesj	542	8	reported	report	VBN
cord-000248-zueoyesj	542	9	in	in	IN
cord-000248-zueoyesj	542	10	prostate	prostate	NN
cord-000248-zueoyesj	542	11	cancer	cancer	NN
cord-000248-zueoyesj	542	12	and	and	CC
cord-000248-zueoyesj	542	13	it	-PRON-	PRP
cord-000248-zueoyesj	542	14	is	be	VBZ
cord-000248-zueoyesj	542	15	the	the	DT
cord-000248-zueoyesj	542	16	object	object	NN
cord-000248-zueoyesj	542	17	of	of	IN
cord-000248-zueoyesj	542	18	a	a	DT
cord-000248-zueoyesj	542	19	study	study	NN
cord-000248-zueoyesj	542	20	that	that	WDT
cord-000248-zueoyesj	542	21	attempts	attempt	VBZ
cord-000248-zueoyesj	542	22	to	to	TO
cord-000248-zueoyesj	542	23	establish	establish	VB
cord-000248-zueoyesj	542	24	dendritic	dendritic	JJ
cord-000248-zueoyesj	542	25	cell	cell	NN
cord-000248-zueoyesj	542	26	gene	gene	NN
cord-000248-zueoyesj	542	27	therapies	therapy	NNS
cord-000248-zueoyesj	542	28	[	[	-LRB-
cord-000248-zueoyesj	542	29	504	504	CD
cord-000248-zueoyesj	542	30	,	,	,
cord-000248-zueoyesj	542	31	505	505	CD
cord-000248-zueoyesj	542	32	,	,	,
cord-000248-zueoyesj	542	33	506	506	CD
cord-000248-zueoyesj	542	34	,	,	,
cord-000248-zueoyesj	542	35	507	507	CD
cord-000248-zueoyesj	542	36	,	,	,
cord-000248-zueoyesj	542	37	508	508	CD
cord-000248-zueoyesj	542	38	,	,	,
cord-000248-zueoyesj	542	39	509	509	CD
cord-000248-zueoyesj	542	40	,	,	,
cord-000248-zueoyesj	542	41	510	510	CD
cord-000248-zueoyesj	542	42	,	,	,
cord-000248-zueoyesj	542	43	511	511	CD
cord-000248-zueoyesj	542	44	,	,	,
cord-000248-zueoyesj	542	45	512	512	CD
cord-000248-zueoyesj	542	46	,	,	,
cord-000248-zueoyesj	542	47	513	513	CD
cord-000248-zueoyesj	542	48	,	,	,
cord-000248-zueoyesj	542	49	514	514	CD
cord-000248-zueoyesj	542	50	,	,	,
cord-000248-zueoyesj	542	51	515	515	CD
cord-000248-zueoyesj	542	52	,	,	,
cord-000248-zueoyesj	542	53	516	516	CD
cord-000248-zueoyesj	542	54	,	,	,
cord-000248-zueoyesj	542	55	517	517	CD
cord-000248-zueoyesj	542	56	,	,	,
cord-000248-zueoyesj	542	57	518	518	CD
cord-000248-zueoyesj	542	58	,	,	,
cord-000248-zueoyesj	542	59	519	519	CD
cord-000248-zueoyesj	542	60	,	,	,
cord-000248-zueoyesj	542	61	520	520	CD
cord-000248-zueoyesj	542	62	,	,	,
cord-000248-zueoyesj	542	63	521	521	CD
cord-000248-zueoyesj	542	64	,	,	,
cord-000248-zueoyesj	542	65	522	522	CD
cord-000248-zueoyesj	542	66	]	]	-RRB-
cord-000248-zueoyesj	542	67	.	.	.
cord-000248-zueoyesj	543	1	We	-PRON-	PRP
cord-000248-zueoyesj	543	2	will	will	MD
cord-000248-zueoyesj	543	3	continue	continue	VB
cord-000248-zueoyesj	543	4	discussing	discuss	VBG
cord-000248-zueoyesj	543	5	CD40	CD40	NNP
cord-000248-zueoyesj	543	6	in	in	IN
cord-000248-zueoyesj	543	7	the	the	DT
cord-000248-zueoyesj	543	8	following	follow	VBG
cord-000248-zueoyesj	543	9	subsection	subsection	NN
cord-000248-zueoyesj	543	10	in	in	IN
cord-000248-zueoyesj	543	11	concert	concert	NN
cord-000248-zueoyesj	543	12	with	with	IN
cord-000248-zueoyesj	543	13	other	other	JJ
cord-000248-zueoyesj	543	14	genes	gene	NNS
cord-000248-zueoyesj	543	15	.	.	.
cord-000248-zueoyesj	544	1	Another	another	DT
cord-000248-zueoyesj	544	2	natural	natural	JJ
cord-000248-zueoyesj	544	3	question	question	NN
cord-000248-zueoyesj	544	4	can	can	MD
cord-000248-zueoyesj	544	5	be	be	VB
cord-000248-zueoyesj	544	6	asked	ask	VBN
cord-000248-zueoyesj	544	7	:	:	:
cord-000248-zueoyesj	544	8	Which	which	WDT
cord-000248-zueoyesj	544	9	is	be	VBZ
cord-000248-zueoyesj	544	10	the	the	DT
cord-000248-zueoyesj	544	11	extra	extra	JJ
cord-000248-zueoyesj	544	12	information	information	NN
cord-000248-zueoyesj	544	13	that	that	WDT
cord-000248-zueoyesj	544	14	we	-PRON-	PRP
cord-000248-zueoyesj	544	15	can	can	MD
cord-000248-zueoyesj	544	16	obtain	obtain	VB
cord-000248-zueoyesj	544	17	the	the	DT
cord-000248-zueoyesj	544	18	by	by	IN
cord-000248-zueoyesj	544	19	analysing	analyse	VBG
cord-000248-zueoyesj	544	20	the	the	DT
cord-000248-zueoyesj	544	21	correlations	correlation	NNS
cord-000248-zueoyesj	544	22	with	with	IN
cord-000248-zueoyesj	544	23	the	the	DT
cord-000248-zueoyesj	544	24	MPR	MPR	NNP
cord-000248-zueoyesj	544	25	-	-	HYPH
cord-000248-zueoyesj	544	26	Statistical	Statistical	NNP
cord-000248-zueoyesj	544	27	Complexity	Complexity	NNP
cord-000248-zueoyesj	544	28	in	in	IN
cord-000248-zueoyesj	544	29	this	this	DT
cord-000248-zueoyesj	544	30	case	case	NN
cord-000248-zueoyesj	544	31	?	?	.
cord-000248-zueoyesj	545	1	As	as	IN
cord-000248-zueoyesj	545	2	we	-PRON-	PRP
cord-000248-zueoyesj	545	3	have	have	VBP
cord-000248-zueoyesj	545	4	discussed	discuss	VBN
cord-000248-zueoyesj	545	5	before	before	RB
cord-000248-zueoyesj	545	6	,	,	,
cord-000248-zueoyesj	545	7	and	and	CC
cord-000248-zueoyesj	545	8	can	can	MD
cord-000248-zueoyesj	545	9	be	be	VB
cord-000248-zueoyesj	545	10	appreciated	appreciate	VBN
cord-000248-zueoyesj	545	11	from	from	IN
cord-000248-zueoyesj	545	12	Figure	Figure	NNP
cord-000248-zueoyesj	545	13	14	14	CD
cord-000248-zueoyesj	545	14	,	,	,
cord-000248-zueoyesj	545	15	there	there	EX
cord-000248-zueoyesj	545	16	is	be	VBZ
cord-000248-zueoyesj	545	17	a	a	DT
cord-000248-zueoyesj	545	18	strong	strong	JJ
cord-000248-zueoyesj	545	19	correlation	correlation	NN
cord-000248-zueoyesj	545	20	between	between	IN
cord-000248-zueoyesj	545	21	the	the	DT
cord-000248-zueoyesj	545	22	MPR	MPR	NNP
cord-000248-zueoyesj	545	23	-	-	HYPH
cord-000248-zueoyesj	545	24	Statistical	Statistical	NNP
cord-000248-zueoyesj	545	25	Complexity	Complexity	NNP
cord-000248-zueoyesj	545	26	and	and	CC
cord-000248-zueoyesj	545	27	the	the	DT
cord-000248-zueoyesj	545	28	value	value	NN
cord-000248-zueoyesj	545	29	of	of	IN
cord-000248-zueoyesj	545	30	the	the	DT
cord-000248-zueoyesj	545	31	Normalized	Normalized	NNP
cord-000248-zueoyesj	545	32	Shannon	Shannon	NNP
cord-000248-zueoyesj	545	33	Entropy	Entropy	NNP
cord-000248-zueoyesj	545	34	.	.	.
cord-000248-zueoyesj	546	1	It	-PRON-	PRP
cord-000248-zueoyesj	546	2	appears	appear	VBZ
cord-000248-zueoyesj	546	3	in	in	IN
cord-000248-zueoyesj	546	4	prostate	prostate	NN
cord-000248-zueoyesj	546	5	cancer	cancer	NN
cord-000248-zueoyesj	546	6	,	,	,
cord-000248-zueoyesj	546	7	as	as	IN
cord-000248-zueoyesj	546	8	in	in	IN
cord-000248-zueoyesj	546	9	this	this	DT
cord-000248-zueoyesj	546	10	gene	gene	NN
cord-000248-zueoyesj	546	11	expression	expression	NN
cord-000248-zueoyesj	546	12	dataset	dataset	NN
cord-000248-zueoyesj	546	13	,	,	,
cord-000248-zueoyesj	546	14	the	the	DT
cord-000248-zueoyesj	546	15	reduction	reduction	NN
cord-000248-zueoyesj	546	16	of	of	IN
cord-000248-zueoyesj	546	17	Entropy	Entropy	NNP
cord-000248-zueoyesj	546	18	is	be	VBZ
cord-000248-zueoyesj	546	19	not	not	RB
cord-000248-zueoyesj	546	20	the	the	DT
cord-000248-zueoyesj	546	21	major	major	JJ
cord-000248-zueoyesj	546	22	factor	factor	NN
cord-000248-zueoyesj	546	23	responsible	responsible	JJ
cord-000248-zueoyesj	546	24	for	for	IN
cord-000248-zueoyesj	546	25	the	the	DT
cord-000248-zueoyesj	546	26	increase	increase	NN
cord-000248-zueoyesj	546	27	in	in	IN
cord-000248-zueoyesj	546	28	MPR	MPR	NNP
cord-000248-zueoyesj	546	29	-	-	HYPH
cord-000248-zueoyesj	546	30	Statistical	Statistical	NNP
cord-000248-zueoyesj	546	31	Complexity	Complexity	NNP
cord-000248-zueoyesj	546	32	.	.	.
cord-000248-zueoyesj	547	1	Again	again	RB
cord-000248-zueoyesj	547	2	,	,	,
cord-000248-zueoyesj	547	3	it	-PRON-	PRP
cord-000248-zueoyesj	547	4	is	be	VBZ
cord-000248-zueoyesj	547	5	perhaps	perhaps	RB
cord-000248-zueoyesj	547	6	better	well	JJR
cord-000248-zueoyesj	547	7	to	to	TO
cord-000248-zueoyesj	547	8	now	now	RB
cord-000248-zueoyesj	547	9	look	look	VB
cord-000248-zueoyesj	547	10	at	at	IN
cord-000248-zueoyesj	547	11	one	one	CD
cord-000248-zueoyesj	547	12	of	of	IN
cord-000248-zueoyesj	547	13	the	the	DT
cord-000248-zueoyesj	547	14	multiplicative	multiplicative	JJ
cord-000248-zueoyesj	547	15	factors	factor	NNS
cord-000248-zueoyesj	547	16	of	of	IN
cord-000248-zueoyesj	547	17	the	the	DT
cord-000248-zueoyesj	547	18	statistical	statistical	JJ
cord-000248-zueoyesj	547	19	complexity	complexity	NN
cord-000248-zueoyesj	547	20	measure	measure	NN
cord-000248-zueoyesj	547	21	,	,	,
cord-000248-zueoyesj	547	22	the	the	DT
cord-000248-zueoyesj	547	23	Jensen	Jensen	NNP
cord-000248-zueoyesj	547	24	-	-	HYPH
cord-000248-zueoyesj	547	25	Shannon	Shannon	NNP
cord-000248-zueoyesj	547	26	divergence	divergence	NN
cord-000248-zueoyesj	547	27	to	to	IN
cord-000248-zueoyesj	547	28	the	the	DT
cord-000248-zueoyesj	547	29	equiprobability	equiprobability	NN
cord-000248-zueoyesj	547	30	distribution	distribution	NN
cord-000248-zueoyesj	547	31	,	,	,
cord-000248-zueoyesj	547	32	as	as	IN
cord-000248-zueoyesj	547	33	this	this	DT
cord-000248-zueoyesj	547	34	is	be	VBZ
cord-000248-zueoyesj	547	35	increasing	increase	VBG
cord-000248-zueoyesj	547	36	the	the	DT
cord-000248-zueoyesj	547	37	MPR	mpr	NN
cord-000248-zueoyesj	547	38	-	-	NN
cord-000248-zueoyesj	547	39	complexity	complexity	NN
cord-000248-zueoyesj	547	40	.	.	.
cord-000248-zueoyesj	548	1	CD40	CD40	NNP
cord-000248-zueoyesj	548	2	.	.	.
cord-000248-zueoyesj	549	1	We	-PRON-	PRP
cord-000248-zueoyesj	549	2	present	present	VBP
cord-000248-zueoyesj	549	3	more	more	JJR
cord-000248-zueoyesj	549	4	evidence	evidence	NN
cord-000248-zueoyesj	549	5	of	of	IN
cord-000248-zueoyesj	549	6	the	the	DT
cord-000248-zueoyesj	549	7	case	case	NN
cord-000248-zueoyesj	549	8	of	of	IN
cord-000248-zueoyesj	549	9	CD40	CD40	NNP
cord-000248-zueoyesj	549	10	as	as	IN
cord-000248-zueoyesj	549	11	a	a	DT
cord-000248-zueoyesj	549	12	biomarker	biomarker	NN
cord-000248-zueoyesj	549	13	,	,	,
cord-000248-zueoyesj	549	14	since	since	IN
cord-000248-zueoyesj	549	15	a	a	DT
cord-000248-zueoyesj	549	16	probe	probe	NN
cord-000248-zueoyesj	549	17	for	for	IN
cord-000248-zueoyesj	549	18	CD40	CD40	NNP
cord-000248-zueoyesj	549	19	(	(	-LRB-
cord-000248-zueoyesj	549	20	BX381481	BX381481	NNP
cord-000248-zueoyesj	549	21	)	)	-RRB-
cord-000248-zueoyesj	549	22	ranks	rank	VBZ
cord-000248-zueoyesj	549	23	6	6	CD
cord-000248-zueoyesj	549	24	th	th	XX
cord-000248-zueoyesj	550	1	(	(	-LRB-
cord-000248-zueoyesj	550	2	the	the	DT
cord-000248-zueoyesj	550	3	Spearman	Spearman	NNP
cord-000248-zueoyesj	550	4	correlation	correlation	NN
cord-000248-zueoyesj	550	5	of	of	IN
cord-000248-zueoyesj	550	6	the	the	DT
cord-000248-zueoyesj	550	7	probe	probe	NN
cord-000248-zueoyesj	550	8	expression	expression	NN
cord-000248-zueoyesj	550	9	with	with	IN
cord-000248-zueoyesj	550	10	the	the	DT
cord-000248-zueoyesj	550	11	Jensen	Jensen	NNP
cord-000248-zueoyesj	550	12	-	-	HYPH
cord-000248-zueoyesj	550	13	Shannon	Shannon	NNP
cord-000248-zueoyesj	550	14	divergence	divergence	NN
cord-000248-zueoyesj	550	15	from	from	IN
cord-000248-zueoyesj	550	16	the	the	DT
cord-000248-zueoyesj	550	17	equiprobability	equiprobability	NN
cord-000248-zueoyesj	550	18	distribution	distribution	NN
cord-000248-zueoyesj	550	19	is	be	VBZ
cord-000248-zueoyesj	550	20	20.5764	20.5764	CD
cord-000248-zueoyesj	550	21	)	)	-RRB-
cord-000248-zueoyesj	550	22	.	.	.
cord-000248-zueoyesj	551	1	CD40	CD40	NNP
cord-000248-zueoyesj	551	2	is	be	VBZ
cord-000248-zueoyesj	551	3	a	a	DT
cord-000248-zueoyesj	551	4	member	member	NN
cord-000248-zueoyesj	551	5	of	of	IN
cord-000248-zueoyesj	551	6	the	the	DT
cord-000248-zueoyesj	551	7	TNF	TNF	NNP
cord-000248-zueoyesj	551	8	receptor	receptor	NN
cord-000248-zueoyesj	551	9	superfamily	superfamily	NN
cord-000248-zueoyesj	551	10	.	.	.
cord-000248-zueoyesj	552	1	Notably	notably	RB
cord-000248-zueoyesj	552	2	,	,	,
cord-000248-zueoyesj	552	3	in	in	IN
cord-000248-zueoyesj	552	4	56	56	CD
cord-000248-zueoyesj	552	5	out	out	IN
cord-000248-zueoyesj	552	6	of	of	IN
cord-000248-zueoyesj	552	7	57	57	CD
cord-000248-zueoyesj	552	8	archival	archival	JJ
cord-000248-zueoyesj	552	9	prostate	prostate	NN
cord-000248-zueoyesj	552	10	cancer	cancer	NN
cord-000248-zueoyesj	552	11	samples	sample	NNS
cord-000248-zueoyesj	552	12	Palmer	Palmer	NNP
cord-000248-zueoyesj	552	13	et	et	NNP
cord-000248-zueoyesj	552	14	al	al	NNP
cord-000248-zueoyesj	552	15	.	.	NNP
cord-000248-zueoyesj	552	16	have	have	VBP
cord-000248-zueoyesj	552	17	reported	report	VBN
cord-000248-zueoyesj	552	18	no	no	DT
cord-000248-zueoyesj	552	19	CD40	CD40	NNP
cord-000248-zueoyesj	552	20	expression	expression	NN
cord-000248-zueoyesj	552	21	[	[	-LRB-
cord-000248-zueoyesj	552	22	518	518	CD
cord-000248-zueoyesj	552	23	]	]	-RRB-
cord-000248-zueoyesj	552	24	.	.	.
cord-000248-zueoyesj	553	1	However	however	RB
cord-000248-zueoyesj	553	2	,	,	,
cord-000248-zueoyesj	553	3	CD40	cd40	JJ
cord-000248-zueoyesj	553	4	expression	expression	NN
cord-000248-zueoyesj	553	5	was	be	VBD
cord-000248-zueoyesj	553	6	present	present	JJ
cord-000248-zueoyesj	553	7	in	in	IN
cord-000248-zueoyesj	553	8	normal	normal	JJ
cord-000248-zueoyesj	553	9	prostatic	prostatic	JJ
cord-000248-zueoyesj	553	10	acini	acinus	NNS
cord-000248-zueoyesj	553	11	,	,	,
cord-000248-zueoyesj	553	12	so	so	RB
cord-000248-zueoyesj	553	13	they	-PRON-	PRP
cord-000248-zueoyesj	553	14	proposed	propose	VBD
cord-000248-zueoyesj	553	15	that	that	IN
cord-000248-zueoyesj	553	16	'	'	``
cord-000248-zueoyesj	553	17	'	'	``
cord-000248-zueoyesj	553	18	invasive	invasive	JJ
cord-000248-zueoyesj	553	19	prostate	prostate	NN
cord-000248-zueoyesj	553	20	cancer	cancer	NN
cord-000248-zueoyesj	553	21	is	be	VBZ
cord-000248-zueoyesj	553	22	a	a	DT
cord-000248-zueoyesj	553	23	CD40-negative	CD40-negative	NNP
cord-000248-zueoyesj	553	24	tumour	tumour	NN
cord-000248-zueoyesj	553	25	'	'	''
cord-000248-zueoyesj	553	26	'	'	''
cord-000248-zueoyesj	554	1	(	(	-LRB-
cord-000248-zueoyesj	554	2	see	see	VB
cord-000248-zueoyesj	554	3	the	the	DT
cord-000248-zueoyesj	554	4	previous	previous	JJ
cord-000248-zueoyesj	554	5	results	result	NNS
cord-000248-zueoyesj	554	6	of	of	IN
cord-000248-zueoyesj	554	7	Moghaddami	Moghaddami	NNP
cord-000248-zueoyesj	554	8	et	et	NNP
cord-000248-zueoyesj	554	9	.	.	.
cord-000248-zueoyesj	555	1	al	al	NNP
cord-000248-zueoyesj	555	2	.	.	.
cord-000248-zueoyesj	556	1	[	[	-LRB-
cord-000248-zueoyesj	556	2	514	514	CD
cord-000248-zueoyesj	556	3	]	]	-RRB-
cord-000248-zueoyesj	556	4	)	)	-RRB-
cord-000248-zueoyesj	556	5	.	.	.
cord-000248-zueoyesj	557	1	Matching	match	VBG
cord-000248-zueoyesj	557	2	our	-PRON-	PRP$
cord-000248-zueoyesj	557	3	observations	observation	NNS
cord-000248-zueoyesj	557	4	,	,	,
cord-000248-zueoyesj	557	5	they	-PRON-	PRP
cord-000248-zueoyesj	557	6	proposed	propose	VBD
cord-000248-zueoyesj	557	7	that	that	IN
cord-000248-zueoyesj	557	8	CD40	CD40	NNP
cord-000248-zueoyesj	557	9	provides	provide	VBZ
cord-000248-zueoyesj	557	10	'	'	``
cord-000248-zueoyesj	557	11	'	'	``
cord-000248-zueoyesj	557	12	insight	insight	NN
cord-000248-zueoyesj	557	13	into	into	IN
cord-000248-zueoyesj	557	14	progression	progression	NN
cord-000248-zueoyesj	557	15	of	of	IN
cord-000248-zueoyesj	557	16	cancer	cancer	NN
cord-000248-zueoyesj	557	17	from	from	IN
cord-000248-zueoyesj	557	18	normal	normal	JJ
cord-000248-zueoyesj	557	19	epithelium	epithelium	NN
cord-000248-zueoyesj	557	20	'	'	''
cord-000248-zueoyesj	557	21	'	'	''
cord-000248-zueoyesj	557	22	;	;	:
cord-000248-zueoyesj	557	23	our	-PRON-	PRP$
cord-000248-zueoyesj	557	24	proposed	propose	VBN
cord-000248-zueoyesj	557	25	methodology	methodology	NN
cord-000248-zueoyesj	557	26	is	be	VBZ
cord-000248-zueoyesj	557	27	revealing	reveal	VBG
cord-000248-zueoyesj	557	28	this	this	DT
cord-000248-zueoyesj	557	29	fact	fact	NN
cord-000248-zueoyesj	557	30	as	as	RB
cord-000248-zueoyesj	557	31	well	well	RB
cord-000248-zueoyesj	557	32	.	.	.
cord-000248-zueoyesj	558	1	Depletion	depletion	NN
cord-000248-zueoyesj	558	2	of	of	IN
cord-000248-zueoyesj	558	3	CD40	CD40	NNP
cord-000248-zueoyesj	558	4	in	in	IN
cord-000248-zueoyesj	558	5	the	the	DT
cord-000248-zueoyesj	558	6	tumour	tumour	NN
cord-000248-zueoyesj	558	7	microenvironment	microenvironment	NN
cord-000248-zueoyesj	558	8	may	may	MD
cord-000248-zueoyesj	558	9	be	be	VB
cord-000248-zueoyesj	558	10	central	central	JJ
cord-000248-zueoyesj	558	11	in	in	IN
cord-000248-zueoyesj	558	12	avoiding	avoid	VBG
cord-000248-zueoyesj	558	13	the	the	DT
cord-000248-zueoyesj	558	14	action	action	NN
cord-000248-zueoyesj	558	15	of	of	IN
cord-000248-zueoyesj	558	16	the	the	DT
cord-000248-zueoyesj	558	17	immune	immune	JJ
cord-000248-zueoyesj	558	18	system	system	NN
cord-000248-zueoyesj	558	19	[	[	-LRB-
cord-000248-zueoyesj	558	20	506	506	CD
cord-000248-zueoyesj	558	21	]	]	-RRB-
cord-000248-zueoyesj	558	22	,	,	,
cord-000248-zueoyesj	558	23	as	as	IN
cord-000248-zueoyesj	558	24	prostate	prostate	NN
cord-000248-zueoyesj	558	25	cancer	cancer	NN
cord-000248-zueoyesj	558	26	induces	induce	VBZ
cord-000248-zueoyesj	558	27	a	a	DT
cord-000248-zueoyesj	558	28	progressive	progressive	JJ
cord-000248-zueoyesj	558	29	suppression	suppression	NN
cord-000248-zueoyesj	558	30	of	of	IN
cord-000248-zueoyesj	558	31	the	the	DT
cord-000248-zueoyesj	558	32	dendritic	dendritic	JJ
cord-000248-zueoyesj	558	33	cell	cell	NN
cord-000248-zueoyesj	558	34	system	system	NN
cord-000248-zueoyesj	558	35	[	[	-LRB-
cord-000248-zueoyesj	558	36	520	520	CD
cord-000248-zueoyesj	558	37	]	]	-RRB-
cord-000248-zueoyesj	558	38	.	.	.
cord-000248-zueoyesj	559	1	It	-PRON-	PRP
cord-000248-zueoyesj	559	2	is	be	VBZ
cord-000248-zueoyesj	559	3	perhaps	perhaps	RB
cord-000248-zueoyesj	559	4	a	a	DT
cord-000248-zueoyesj	559	5	central	central	JJ
cord-000248-zueoyesj	559	6	piece	piece	NN
cord-000248-zueoyesj	559	7	which	which	WDT
cord-000248-zueoyesj	559	8	should	should	MD
cord-000248-zueoyesj	559	9	be	be	VB
cord-000248-zueoyesj	559	10	put	put	VBN
cord-000248-zueoyesj	559	11	together	together	RB
cord-000248-zueoyesj	559	12	in	in	IN
cord-000248-zueoyesj	559	13	the	the	DT
cord-000248-zueoyesj	559	14	context	context	NN
cord-000248-zueoyesj	559	15	of	of	IN
cord-000248-zueoyesj	559	16	other	other	JJ
cord-000248-zueoyesj	559	17	pieces	piece	NNS
cord-000248-zueoyesj	559	18	of	of	IN
cord-000248-zueoyesj	559	19	information	information	NN
cord-000248-zueoyesj	559	20	coming	come	VBG
cord-000248-zueoyesj	559	21	from	from	IN
cord-000248-zueoyesj	559	22	immunotherapy	immunotherapy	NN
cord-000248-zueoyesj	559	23	[	[	-LRB-
cord-000248-zueoyesj	559	24	508	508	CD
cord-000248-zueoyesj	559	25	,	,	,
cord-000248-zueoyesj	559	26	512	512	CD
cord-000248-zueoyesj	559	27	,	,	,
cord-000248-zueoyesj	559	28	513	513	CD
cord-000248-zueoyesj	559	29	,	,	,
cord-000248-zueoyesj	559	30	516	516	CD
cord-000248-zueoyesj	559	31	]	]	-RRB-
cord-000248-zueoyesj	559	32	and	and	CC
cord-000248-zueoyesj	559	33	pharmacological	pharmacological	JJ
cord-000248-zueoyesj	559	34	studies	study	NNS
cord-000248-zueoyesj	559	35	[	[	-LRB-
cord-000248-zueoyesj	559	36	507	507	CD
cord-000248-zueoyesj	559	37	]	]	-RRB-
cord-000248-zueoyesj	559	38	that	that	WDT
cord-000248-zueoyesj	559	39	warrant	warrant	VBP
cord-000248-zueoyesj	559	40	serious	serious	JJ
cord-000248-zueoyesj	559	41	investigation	investigation	NN
cord-000248-zueoyesj	559	42	towards	towards	IN
cord-000248-zueoyesj	559	43	the	the	DT
cord-000248-zueoyesj	559	44	design	design	NN
cord-000248-zueoyesj	559	45	of	of	IN
cord-000248-zueoyesj	559	46	new	new	JJ
cord-000248-zueoyesj	559	47	and	and	CC
cord-000248-zueoyesj	559	48	improved	improved	JJ
cord-000248-zueoyesj	559	49	clinical	clinical	JJ
cord-000248-zueoyesj	559	50	studies	study	NNS
cord-000248-zueoyesj	559	51	[	[	-LRB-
cord-000248-zueoyesj	559	52	508	508	CD
cord-000248-zueoyesj	559	53	,	,	,
cord-000248-zueoyesj	559	54	517	517	CD
cord-000248-zueoyesj	559	55	]	]	-RRB-
cord-000248-zueoyesj	559	56	.	.	.
cord-000248-zueoyesj	560	1	CD59	CD59	NNP
cord-000248-zueoyesj	560	2	molecule	molecule	NN
cord-000248-zueoyesj	560	3	,	,	,
cord-000248-zueoyesj	560	4	complement	complement	VB
cord-000248-zueoyesj	560	5	regulatory	regulatory	JJ
cord-000248-zueoyesj	560	6	protein	protein	NN
cord-000248-zueoyesj	560	7	.	.	.
cord-000248-zueoyesj	561	1	Four	four	CD
cord-000248-zueoyesj	561	2	probes	probe	NNS
cord-000248-zueoyesj	561	3	for	for	IN
cord-000248-zueoyesj	561	4	protectin	protectin	NNP
cord-000248-zueoyesj	561	5	[	[	-LRB-
cord-000248-zueoyesj	561	6	335	335	CD
cord-000248-zueoyesj	561	7	,	,	,
cord-000248-zueoyesj	561	8	523	523	CD
cord-000248-zueoyesj	561	9	,	,	,
cord-000248-zueoyesj	561	10	524	524	CD
cord-000248-zueoyesj	561	11	]	]	-RRB-
cord-000248-zueoyesj	561	12	,	,	,
cord-000248-zueoyesj	561	13	CD59	CD59	NNP
cord-000248-zueoyesj	561	14	,	,	,
cord-000248-zueoyesj	561	15	with	with	IN
cord-000248-zueoyesj	561	16	Spearman	Spearman	NNP
cord-000248-zueoyesj	561	17	correlations	correlation	NNS
cord-000248-zueoyesj	561	18	with	with	IN
cord-000248-zueoyesj	561	19	the	the	DT
cord-000248-zueoyesj	561	20	Jensen	Jensen	NNP
cord-000248-zueoyesj	561	21	-	-	HYPH
cord-000248-zueoyesj	561	22	Shannon	Shannon	NNP
cord-000248-zueoyesj	561	23	divergence	divergence	NN
cord-000248-zueoyesj	561	24	from	from	IN
cord-000248-zueoyesj	561	25	the	the	DT
cord-000248-zueoyesj	561	26	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	561	27	distribution	distribution	NN
cord-000248-zueoyesj	561	28	,	,	,
cord-000248-zueoyesj	561	29	ranging	range	VBG
cord-000248-zueoyesj	561	30	from	from	IN
cord-000248-zueoyesj	561	31	20.61823	20.61823	CD
cord-000248-zueoyesj	561	32	to	to	IN
cord-000248-zueoyesj	561	33	20.5089	20.5089	CD
cord-000248-zueoyesj	561	34	,	,	,
cord-000248-zueoyesj	561	35	rank	rank	VBP
cord-000248-zueoyesj	561	36	between	between	IN
cord-000248-zueoyesj	561	37	the	the	DT
cord-000248-zueoyesj	561	38	1	1	CD
cord-000248-zueoyesj	561	39	st	st	NNP
cord-000248-zueoyesj	561	40	and	and	CC
cord-000248-zueoyesj	561	41	39	39	CD
cord-000248-zueoyesj	561	42	th	th	XX
cord-000248-zueoyesj	561	43	position	position	NN
cord-000248-zueoyesj	561	44	(	(	-LRB-
cord-000248-zueoyesj	561	45	when	when	WRB
cord-000248-zueoyesj	561	46	we	-PRON-	PRP
cord-000248-zueoyesj	561	47	rank	rank	VBP
cord-000248-zueoyesj	561	48	genes	gene	NNS
cord-000248-zueoyesj	561	49	according	accord	VBG
cord-000248-zueoyesj	561	50	to	to	IN
cord-000248-zueoyesj	561	51	this	this	DT
cord-000248-zueoyesj	561	52	correlation	correlation	NN
cord-000248-zueoyesj	561	53	in	in	IN
cord-000248-zueoyesj	561	54	ascending	ascend	VBG
cord-000248-zueoyesj	561	55	order	order	NN
cord-000248-zueoyesj	561	56	)	)	-RRB-
cord-000248-zueoyesj	561	57	.	.	.
cord-000248-zueoyesj	562	1	CD59	CD59	NNP
cord-000248-zueoyesj	562	2	is	be	VBZ
cord-000248-zueoyesj	562	3	an	an	DT
cord-000248-zueoyesj	562	4	interesting	interesting	JJ
cord-000248-zueoyesj	562	5	gene	gene	NN
cord-000248-zueoyesj	562	6	as	as	IN
cord-000248-zueoyesj	562	7	'	'	''
cord-000248-zueoyesj	562	8	'	'	''
cord-000248-zueoyesj	562	9	a	a	DT
cord-000248-zueoyesj	562	10	comprehensive	comprehensive	JJ
cord-000248-zueoyesj	562	11	investigation	investigation	NN
cord-000248-zueoyesj	562	12	of	of	IN
cord-000248-zueoyesj	562	13	CD59	CD59	NNP
cord-000248-zueoyesj	562	14	expression	expression	NN
cord-000248-zueoyesj	562	15	in	in	IN
cord-000248-zueoyesj	562	16	prostate	prostate	NN
cord-000248-zueoyesj	562	17	cancer	cancer	NN
cord-000248-zueoyesj	562	18	has	have	VBZ
cord-000248-zueoyesj	562	19	not	not	RB
cord-000248-zueoyesj	562	20	been	be	VBN
cord-000248-zueoyesj	562	21	conducted	conduct	VBN
cord-000248-zueoyesj	562	22	yet	yet	RB
cord-000248-zueoyesj	562	23	'	'	''
cord-000248-zueoyesj	562	24	'	'	''
cord-000248-zueoyesj	562	25	[	[	-LRB-
cord-000248-zueoyesj	562	26	524	524	CD
cord-000248-zueoyesj	562	27	]	]	-RRB-
cord-000248-zueoyesj	562	28	.	.	.
cord-000248-zueoyesj	563	1	Like	like	IN
cord-000248-zueoyesj	563	2	LMNA	LMNA	NNP
cord-000248-zueoyesj	563	3	(	(	-LRB-
cord-000248-zueoyesj	563	4	which	which	WDT
cord-000248-zueoyesj	563	5	is	be	VBZ
cord-000248-zueoyesj	563	6	ranked	rank	VBN
cord-000248-zueoyesj	563	7	third	third	RB
cord-000248-zueoyesj	563	8	and	and	CC
cord-000248-zueoyesj	563	9	will	will	MD
cord-000248-zueoyesj	563	10	be	be	VB
cord-000248-zueoyesj	563	11	discussed	discuss	VBN
cord-000248-zueoyesj	563	12	later	later	RB
cord-000248-zueoyesj	563	13	)	)	-RRB-
cord-000248-zueoyesj	564	1	the	the	DT
cord-000248-zueoyesj	564	2	rank	rank	NN
cord-000248-zueoyesj	564	3	of	of	IN
cord-000248-zueoyesj	564	4	CD59/	CD59/	NNP
cord-000248-zueoyesj	564	5	protectin	protectin	NNP
cord-000248-zueoyesj	564	6	means	mean	VBZ
cord-000248-zueoyesj	564	7	that	that	IN
cord-000248-zueoyesj	564	8	these	these	DT
cord-000248-zueoyesj	564	9	genes	gene	NNS
cord-000248-zueoyesj	564	10	progressively	progressively	RB
cord-000248-zueoyesj	564	11	loose	loose	JJ
cord-000248-zueoyesj	564	12	expression	expression	NN
cord-000248-zueoyesj	564	13	of	of	IN
cord-000248-zueoyesj	564	14	these	these	DT
cord-000248-zueoyesj	564	15	probes	probe	NNS
cord-000248-zueoyesj	564	16	.	.	.
cord-000248-zueoyesj	565	1	CD59	CD59	NNP
cord-000248-zueoyesj	565	2	is	be	VBZ
cord-000248-zueoyesj	565	3	expressed	express	VBN
cord-000248-zueoyesj	565	4	in	in	IN
cord-000248-zueoyesj	565	5	the	the	DT
cord-000248-zueoyesj	565	6	prostatic	prostatic	JJ
cord-000248-zueoyesj	565	7	epithelium	epithelium	NN
cord-000248-zueoyesj	565	8	[	[	-LRB-
cord-000248-zueoyesj	565	9	525	525	CD
cord-000248-zueoyesj	565	10	]	]	-RRB-
cord-000248-zueoyesj	565	11	and	and	CC
cord-000248-zueoyesj	565	12	in	in	IN
cord-000248-zueoyesj	565	13	prostasomes	prostasome	NNS
cord-000248-zueoyesj	565	14	[	[	-LRB-
cord-000248-zueoyesj	565	15	526	526	CD
cord-000248-zueoyesj	565	16	]	]	-RRB-
cord-000248-zueoyesj	565	17	;	;	:
cord-000248-zueoyesj	565	18	secretory	secretory	JJ
cord-000248-zueoyesj	565	19	granules	granule	NNS
cord-000248-zueoyesj	565	20	which	which	WDT
cord-000248-zueoyesj	565	21	are	be	VBP
cord-000248-zueoyesj	565	22	produced	produce	VBN
cord-000248-zueoyesj	565	23	,	,	,
cord-000248-zueoyesj	565	24	stored	store	VBN
cord-000248-zueoyesj	565	25	and	and	CC
cord-000248-zueoyesj	565	26	released	release	VBN
cord-000248-zueoyesj	565	27	by	by	IN
cord-000248-zueoyesj	565	28	the	the	DT
cord-000248-zueoyesj	565	29	glandular	glandular	JJ
cord-000248-zueoyesj	565	30	epithelial	epithelial	JJ
cord-000248-zueoyesj	565	31	cells	cell	NNS
cord-000248-zueoyesj	565	32	of	of	IN
cord-000248-zueoyesj	565	33	the	the	DT
cord-000248-zueoyesj	565	34	prostate	prostate	NN
cord-000248-zueoyesj	565	35	[	[	-LRB-
cord-000248-zueoyesj	565	36	527	527	CD
cord-000248-zueoyesj	565	37	]	]	-RRB-
cord-000248-zueoyesj	565	38	.	.	.
cord-000248-zueoyesj	566	1	Babiker	Babiker	NNP
cord-000248-zueoyesj	566	2	et	et	NNP
cord-000248-zueoyesj	566	3	al	al	NNP
cord-000248-zueoyesj	566	4	.	.	NNP
cord-000248-zueoyesj	566	5	concluded	conclude	VBD
cord-000248-zueoyesj	566	6	in	in	IN
cord-000248-zueoyesj	566	7	[	[	-LRB-
cord-000248-zueoyesj	566	8	335	335	CD
cord-000248-zueoyesj	566	9	]	]	-RRB-
cord-000248-zueoyesj	566	10	that	that	IN
cord-000248-zueoyesj	566	11	prostasomes	prostasome	NNS
cord-000248-zueoyesj	566	12	(	(	-LRB-
cord-000248-zueoyesj	566	13	via	via	IN
cord-000248-zueoyesj	566	14	expression	expression	NN
cord-000248-zueoyesj	566	15	CD59	CD59	NNP
cord-000248-zueoyesj	566	16	)	)	-RRB-
cord-000248-zueoyesj	566	17	contribute	contribute	VB
cord-000248-zueoyesj	566	18	to	to	IN
cord-000248-zueoyesj	566	19	the	the	DT
cord-000248-zueoyesj	566	20	protection	protection	NN
cord-000248-zueoyesj	566	21	of	of	IN
cord-000248-zueoyesj	566	22	malignant	malignant	JJ
cord-000248-zueoyesj	566	23	cells	cell	NNS
cord-000248-zueoyesj	566	24	from	from	IN
cord-000248-zueoyesj	566	25	complement	complement	JJ
cord-000248-zueoyesj	566	26	attack	attack	NN
cord-000248-zueoyesj	566	27	.	.	.
cord-000248-zueoyesj	567	1	We	-PRON-	PRP
cord-000248-zueoyesj	567	2	now	now	RB
cord-000248-zueoyesj	567	3	investigate	investigate	VBP
cord-000248-zueoyesj	567	4	if	if	IN
cord-000248-zueoyesj	567	5	the	the	DT
cord-000248-zueoyesj	567	6	ratio	ratio	NN
cord-000248-zueoyesj	567	7	of	of	IN
cord-000248-zueoyesj	567	8	deltacatenin	deltacatenin	NN
cord-000248-zueoyesj	567	9	to	to	IN
cord-000248-zueoyesj	567	10	CD59	CD59	NNP
cord-000248-zueoyesj	567	11	can	can	MD
cord-000248-zueoyesj	567	12	is	be	VBZ
cord-000248-zueoyesj	567	13	a	a	DT
cord-000248-zueoyesj	567	14	more	more	RBR
cord-000248-zueoyesj	567	15	robust	robust	JJ
cord-000248-zueoyesj	567	16	biomarker	biomarker	NN
cord-000248-zueoyesj	567	17	for	for	IN
cord-000248-zueoyesj	567	18	non	non	JJ
cord-000248-zueoyesj	567	19	-	-	JJ
cord-000248-zueoyesj	567	20	invasive	invasive	JJ
cord-000248-zueoyesj	567	21	prostate	prostate	NN
cord-000248-zueoyesj	567	22	cancer	cancer	NN
cord-000248-zueoyesj	567	23	detection	detection	NN
cord-000248-zueoyesj	567	24	,	,	,
cord-000248-zueoyesj	567	25	particularly	particularly	RB
cord-000248-zueoyesj	567	26	after	after	IN
cord-000248-zueoyesj	567	27	the	the	DT
cord-000248-zueoyesj	567	28	results	result	NNS
cord-000248-zueoyesj	567	29	presented	present	VBN
cord-000248-zueoyesj	567	30	in	in	IN
cord-000248-zueoyesj	567	31	[	[	-LRB-
cord-000248-zueoyesj	567	32	528	528	CD
cord-000248-zueoyesj	567	33	]	]	-RRB-
cord-000248-zueoyesj	567	34	.	.	.
cord-000248-zueoyesj	568	1	We	-PRON-	PRP
cord-000248-zueoyesj	568	2	also	also	RB
cord-000248-zueoyesj	568	3	note	note	VBP
cord-000248-zueoyesj	568	4	that	that	IN
cord-000248-zueoyesj	568	5	CD59	CD59	NNP
cord-000248-zueoyesj	568	6	may	may	MD
cord-000248-zueoyesj	568	7	be	be	VB
cord-000248-zueoyesj	568	8	also	also	RB
cord-000248-zueoyesj	568	9	relevant	relevant	JJ
cord-000248-zueoyesj	568	10	to	to	TO
cord-000248-zueoyesj	568	11	reveal	reveal	VB
cord-000248-zueoyesj	568	12	the	the	DT
cord-000248-zueoyesj	568	13	heterogeneous	heterogeneous	JJ
cord-000248-zueoyesj	568	14	nature	nature	NN
cord-000248-zueoyesj	568	15	of	of	IN
cord-000248-zueoyesj	568	16	prostate	prostate	NN
cord-000248-zueoyesj	568	17	cancer	cancer	NN
cord-000248-zueoyesj	568	18	.	.	.
cord-000248-zueoyesj	569	1	Its	-PRON-	PRP$
cord-000248-zueoyesj	569	2	correlation	correlation	NN
cord-000248-zueoyesj	569	3	was	be	VBD
cord-000248-zueoyesj	569	4	good	good	JJ
cord-000248-zueoyesj	569	5	,	,	,
cord-000248-zueoyesj	569	6	but	but	CC
cord-000248-zueoyesj	569	7	is	be	VBZ
cord-000248-zueoyesj	569	8	not	not	RB
cord-000248-zueoyesj	569	9	lower	low	JJR
cord-000248-zueoyesj	569	10	than	than	IN
cord-000248-zueoyesj	569	11	20.62	20.62	CD
cord-000248-zueoyesj	569	12	,	,	,
cord-000248-zueoyesj	569	13	which	which	WDT
cord-000248-zueoyesj	569	14	in	in	IN
cord-000248-zueoyesj	569	15	our	-PRON-	PRP$
cord-000248-zueoyesj	569	16	experience	experience	NN
cord-000248-zueoyesj	569	17	,	,	,
cord-000248-zueoyesj	569	18	indicates	indicate	VBZ
cord-000248-zueoyesj	569	19	that	that	IN
cord-000248-zueoyesj	569	20	we	-PRON-	PRP
cord-000248-zueoyesj	569	21	may	may	MD
cord-000248-zueoyesj	569	22	be	be	VB
cord-000248-zueoyesj	569	23	dealing	deal	VBG
cord-000248-zueoyesj	569	24	with	with	IN
cord-000248-zueoyesj	569	25	at	at	RB
cord-000248-zueoyesj	569	26	least	least	RBS
cord-000248-zueoyesj	569	27	two	two	CD
cord-000248-zueoyesj	569	28	types	type	NNS
cord-000248-zueoyesj	569	29	tumors	tumor	NNS
cord-000248-zueoyesj	569	30	in	in	IN
cord-000248-zueoyesj	569	31	this	this	DT
cord-000248-zueoyesj	569	32	dataset	dataset	NN
cord-000248-zueoyesj	569	33	.	.	.
cord-000248-zueoyesj	570	1	Indeed	indeed	RB
cord-000248-zueoyesj	570	2	,	,	,
cord-000248-zueoyesj	570	3	Xu	Xu	NNP
cord-000248-zueoyesj	570	4	et	et	NNP
cord-000248-zueoyesj	570	5	al	al	NNP
cord-000248-zueoyesj	570	6	.	.	.
cord-000248-zueoyesj	571	1	obtained	obtain	VBN
cord-000248-zueoyesj	572	1	CD59	CD59	NNP
cord-000248-zueoyesj	572	2	mRNA	mRNA	NNP
cord-000248-zueoyesj	572	3	levels	level	NNS
cord-000248-zueoyesj	572	4	were	be	VBD
cord-000248-zueoyesj	572	5	determined	determine	VBN
cord-000248-zueoyesj	572	6	by	by	IN
cord-000248-zueoyesj	572	7	real	real	JJ
cord-000248-zueoyesj	572	8	-	-	HYPH
cord-000248-zueoyesj	572	9	time	time	NN
cord-000248-zueoyesj	572	10	PCR	PCR	NNP
cord-000248-zueoyesj	572	11	in	in	IN
cord-000248-zueoyesj	572	12	matched	match	VBN
cord-000248-zueoyesj	572	13	(	(	-LRB-
cord-000248-zueoyesj	572	14	tumor	tumor	NN
cord-000248-zueoyesj	572	15	/	/	SYM
cord-000248-zueoyesj	572	16	normal	normal	JJ
cord-000248-zueoyesj	572	17	)	)	-RRB-
cord-000248-zueoyesj	572	18	microdissected	microdissected	JJ
cord-000248-zueoyesj	572	19	tissues	tissue	NNS
cord-000248-zueoyesj	572	20	from	from	IN
cord-000248-zueoyesj	572	21	26	26	CD
cord-000248-zueoyesj	572	22	cases	case	NNS
cord-000248-zueoyesj	572	23	and	and	CC
cord-000248-zueoyesj	572	24	they	-PRON-	PRP
cord-000248-zueoyesj	572	25	found	find	VBD
cord-000248-zueoyesj	572	26	that	that	DT
cord-000248-zueoyesj	572	27	:	:	:
cord-000248-zueoyesj	572	28	'	'	''
cord-000248-zueoyesj	572	29	'	'	''
cord-000248-zueoyesj	572	30	High	high	JJ
cord-000248-zueoyesj	572	31	rates	rate	NNS
cord-000248-zueoyesj	572	32	of	of	IN
cord-000248-zueoyesj	572	33	CD59	CD59	NNP
cord-000248-zueoyesj	572	34	expression	expression	NN
cord-000248-zueoyesj	572	35	were	be	VBD
cord-000248-zueoyesj	572	36	noted	note	VBN
cord-000248-zueoyesj	572	37	in	in	IN
cord-000248-zueoyesj	572	38	36	36	CD
cord-000248-zueoyesj	572	39	%	%	NN
cord-000248-zueoyesj	572	40	of	of	IN
cord-000248-zueoyesj	572	41	prostate	prostate	NN
cord-000248-zueoyesj	572	42	cancer	cancer	NN
cord-000248-zueoyesj	572	43	cases	case	NNS
cord-000248-zueoyesj	572	44	and	and	CC
cord-000248-zueoyesj	572	45	were	be	VBD
cord-000248-zueoyesj	572	46	significantly	significantly	RB
cord-000248-zueoyesj	572	47	associated	associate	VBN
cord-000248-zueoyesj	572	48	with	with	IN
cord-000248-zueoyesj	572	49	tumor	tumor	NN
cord-000248-zueoyesj	572	50	pT	pt	JJ
cord-000248-zueoyesj	572	51	stage	stage	NN
cord-000248-zueoyesj	573	1	(	(	-LRB-
cord-000248-zueoyesj	573	2	P	p	NN
cord-000248-zueoyesj	573	3	=	=	SYM
cord-000248-zueoyesj	573	4	0.043	0.043	CD
cord-000248-zueoyesj	573	5	)	)	-RRB-
cord-000248-zueoyesj	573	6	,	,	,
cord-000248-zueoyesj	573	7	Gleason	Gleason	NNP
cord-000248-zueoyesj	573	8	grade	grade	NN
cord-000248-zueoyesj	573	9	(	(	-LRB-
cord-000248-zueoyesj	573	10	P	p	NN
cord-000248-zueoyesj	573	11	=	=	SYM
cord-000248-zueoyesj	573	12	0.013	0.013	CD
cord-000248-zueoyesj	573	13	)	)	-RRB-
cord-000248-zueoyesj	573	14	and	and	CC
cord-000248-zueoyesj	573	15	earlier	early	JJR
cord-000248-zueoyesj	573	16	biochemical	biochemical	JJ
cord-000248-zueoyesj	573	17	(	(	-LRB-
cord-000248-zueoyesj	573	18	PSA	PSA	NNP
cord-000248-zueoyesj	573	19	)	)	-RRB-
cord-000248-zueoyesj	573	20	relapse	relapse	NN
cord-000248-zueoyesj	573	21	in	in	IN
cord-000248-zueoyesj	573	22	Kaplan	Kaplan	NNP
cord-000248-zueoyesj	573	23	-	-	HYPH
cord-000248-zueoyesj	573	24	Meier	Meier	NNP
cord-000248-zueoyesj	573	25	analysis	analysis	NN
cord-000248-zueoyesj	574	1	(	(	-LRB-
cord-000248-zueoyesj	574	2	P	p	NN
cord-000248-zueoyesj	574	3	=	=	SYM
cord-000248-zueoyesj	574	4	0.0013	0.0013	CD
cord-000248-zueoyesj	574	5	)	)	-RRB-
cord-000248-zueoyesj	574	6	.	.	.
cord-000248-zueoyesj	575	1	On	on	IN
cord-000248-zueoyesj	575	2	RNA	RNA	NNP
cord-000248-zueoyesj	575	3	level	level	NN
cord-000248-zueoyesj	575	4	,	,	,
cord-000248-zueoyesj	575	5	we	-PRON-	PRP
cord-000248-zueoyesj	575	6	found	find	VBD
cord-000248-zueoyesj	575	7	an	an	DT
cord-000248-zueoyesj	575	8	upregulation	upregulation	NN
cord-000248-zueoyesj	575	9	in	in	IN
cord-000248-zueoyesj	575	10	19.2	19.2	CD
cord-000248-zueoyesj	575	11	%	%	NN
cord-000248-zueoyesj	575	12	(	(	-LRB-
cord-000248-zueoyesj	575	13	five	five	CD
cord-000248-zueoyesj	575	14	cases	case	NNS
cord-000248-zueoyesj	575	15	)	)	-RRB-
cord-000248-zueoyesj	575	16	,	,	,
cord-000248-zueoyesj	575	17	although	although	IN
cord-000248-zueoyesj	575	18	the	the	DT
cord-000248-zueoyesj	575	19	general	general	JJ
cord-000248-zueoyesj	575	20	rate	rate	NN
cord-000248-zueoyesj	575	21	of	of	IN
cord-000248-zueoyesj	575	22	CD59	CD59	NNP
cord-000248-zueoyesj	575	23	transcript	transcript	NN
cord-000248-zueoyesj	575	24	was	be	VBD
cord-000248-zueoyesj	575	25	significantly	significantly	RB
cord-000248-zueoyesj	575	26	lower	low	JJR
cord-000248-zueoyesj	575	27	in	in	IN
cord-000248-zueoyesj	575	28	tumor	tumor	NN
cord-000248-zueoyesj	575	29	tissue	tissue	NN
cord-000248-zueoyesj	575	30	(	(	-LRB-
cord-000248-zueoyesj	575	31	P	p	NN
cord-000248-zueoyesj	575	32	=	=	SYM
cord-000248-zueoyesj	575	33	0.03	0.03	CD
cord-000248-zueoyesj	575	34	)	)	-RRB-
cord-000248-zueoyesj	575	35	'	'	''
cord-000248-zueoyesj	575	36	'	'	''
cord-000248-zueoyesj	575	37	[	[	-LRB-
cord-000248-zueoyesj	575	38	524	524	CD
cord-000248-zueoyesj	575	39	]	]	-RRB-
cord-000248-zueoyesj	575	40	.	.	.
cord-000248-zueoyesj	576	1	They	-PRON-	PRP
cord-000248-zueoyesj	576	2	concluded	conclude	VBD
cord-000248-zueoyesj	576	3	that	that	DT
cord-000248-zueoyesj	576	4	:	:	:
cord-000248-zueoyesj	576	5	'	'	''
cord-000248-zueoyesj	576	6	'	'	''
cord-000248-zueoyesj	576	7	CD59	CD59	NNP
cord-000248-zueoyesj	576	8	protein	protein	NN
cord-000248-zueoyesj	576	9	is	be	VBZ
cord-000248-zueoyesj	576	10	strongly	strongly	RB
cord-000248-zueoyesj	576	11	expressed	express	VBN
cord-000248-zueoyesj	576	12	in	in	IN
cord-000248-zueoyesj	576	13	36	36	CD
cord-000248-zueoyesj	576	14	%	%	NN
cord-000248-zueoyesj	576	15	of	of	IN
cord-000248-zueoyesj	576	16	adenocarcinomas	adenocarcinomas	NNP
cord-000248-zueoyesj	576	17	of	of	IN
cord-000248-zueoyesj	576	18	the	the	DT
cord-000248-zueoyesj	576	19	prostate	prostate	NN
cord-000248-zueoyesj	576	20	and	and	CC
cord-000248-zueoyesj	576	21	and	and	CC
cord-000248-zueoyesj	576	22	is	be	VBZ
cord-000248-zueoyesj	576	23	associated	associate	VBN
cord-000248-zueoyesj	576	24	with	with	IN
cord-000248-zueoyesj	576	25	disease	disease	NN
cord-000248-zueoyesj	576	26	progression	progression	NN
cord-000248-zueoyesj	576	27	and	and	CC
cord-000248-zueoyesj	576	28	adverse	adverse	JJ
cord-000248-zueoyesj	576	29	patient	patient	NN
cord-000248-zueoyesj	576	30	prognosis	prognosis	NN
cord-000248-zueoyesj	576	31	'	'	''
cord-000248-zueoyesj	576	32	'	'	''
cord-000248-zueoyesj	576	33	[	[	-LRB-
cord-000248-zueoyesj	576	34	524	524	CD
cord-000248-zueoyesj	576	35	]	]	-RRB-
cord-000248-zueoyesj	576	36	.	.	.
cord-000248-zueoyesj	577	1	Jarvis	Jarvis	NNP
cord-000248-zueoyesj	577	2	et	et	NNP
cord-000248-zueoyesj	577	3	al	al	NNP
cord-000248-zueoyesj	577	4	.	.	NNP
cord-000248-zueoyesj	577	5	have	have	VBP
cord-000248-zueoyesj	577	6	previously	previously	RB
cord-000248-zueoyesj	577	7	hypothesized	hypothesize	VBN
cord-000248-zueoyesj	577	8	that	that	IN
cord-000248-zueoyesj	577	9	CD59	CD59	NNP
cord-000248-zueoyesj	577	10	expression	expression	NN
cord-000248-zueoyesj	577	11	,	,	,
cord-000248-zueoyesj	577	12	in	in	IN
cord-000248-zueoyesj	577	13	some	some	DT
cord-000248-zueoyesj	577	14	cancer	cancer	NN
cord-000248-zueoyesj	577	15	cells	cell	NNS
cord-000248-zueoyesj	577	16	,	,	,
cord-000248-zueoyesj	577	17	may	may	MD
cord-000248-zueoyesj	577	18	help	help	VB
cord-000248-zueoyesj	577	19	to	to	TO
cord-000248-zueoyesj	577	20	regulate	regulate	VB
cord-000248-zueoyesj	577	21	the	the	DT
cord-000248-zueoyesj	577	22	immunological	immunological	JJ
cord-000248-zueoyesj	577	23	response	response	NN
cord-000248-zueoyesj	577	24	,	,	,
cord-000248-zueoyesj	577	25	protecting	protect	VBG
cord-000248-zueoyesj	577	26	them	-PRON-	PRP
cord-000248-zueoyesj	577	27	from	from	IN
cord-000248-zueoyesj	577	28	the	the	DT
cord-000248-zueoyesj	577	29	cytolytic	cytolytic	JJ
cord-000248-zueoyesj	577	30	activity	activity	NN
cord-000248-zueoyesj	577	31	of	of	IN
cord-000248-zueoyesj	577	32	complement	complement	NN
cord-000248-zueoyesj	577	33	[	[	-LRB-
cord-000248-zueoyesj	577	34	523	523	CD
cord-000248-zueoyesj	577	35	]	]	-RRB-
cord-000248-zueoyesj	577	36	(	(	-LRB-
cord-000248-zueoyesj	577	37	see	see	VB
cord-000248-zueoyesj	577	38	also	also	RB
cord-000248-zueoyesj	577	39	[	[	-LRB-
cord-000248-zueoyesj	577	40	529	529	CD
cord-000248-zueoyesj	577	41	,	,	,
cord-000248-zueoyesj	577	42	530	530	CD
cord-000248-zueoyesj	577	43	]	]	-RRB-
cord-000248-zueoyesj	577	44	)	)	-RRB-
cord-000248-zueoyesj	577	45	.	.	.
cord-000248-zueoyesj	578	1	LMNA	LMNA	NNP
cord-000248-zueoyesj	579	1	(	(	-LRB-
cord-000248-zueoyesj	579	2	Lamin	Lamin	NNP
cord-000248-zueoyesj	579	3	A	A	NNP
cord-000248-zueoyesj	579	4	/	/	SYM
cord-000248-zueoyesj	579	5	C	C	NNP
cord-000248-zueoyesj	579	6	)	)	-RRB-
cord-000248-zueoyesj	579	7	.	.	.
cord-000248-zueoyesj	580	1	The	the	DT
cord-000248-zueoyesj	580	2	third	third	JJ
cord-000248-zueoyesj	580	3	probe	probe	NN
cord-000248-zueoyesj	580	4	in	in	IN
cord-000248-zueoyesj	580	5	the	the	DT
cord-000248-zueoyesj	580	6	ranking	ranking	NN
cord-000248-zueoyesj	580	7	corresponds	correspond	VBZ
cord-000248-zueoyesj	580	8	to	to	IN
cord-000248-zueoyesj	580	9	a	a	DT
cord-000248-zueoyesj	580	10	LMNA	LMNA	NNP
cord-000248-zueoyesj	581	1	(	(	-LRB-
cord-000248-zueoyesj	581	2	Lamin	Lamin	NNP
cord-000248-zueoyesj	581	3	A	A	NNP
cord-000248-zueoyesj	581	4	/	/	SYM
cord-000248-zueoyesj	581	5	C	C	NNP
cord-000248-zueoyesj	581	6	)	)	-RRB-
cord-000248-zueoyesj	581	7	,	,	,
cord-000248-zueoyesj	581	8	AY528714	AY528714	NNP
cord-000248-zueoyesj	581	9	.	.	.
cord-000248-zueoyesj	582	1	Mutations	mutation	NNS
cord-000248-zueoyesj	582	2	on	on	IN
cord-000248-zueoyesj	582	3	LMNA	LMNA	NNP
cord-000248-zueoyesj	582	4	have	have	VBP
cord-000248-zueoyesj	582	5	been	be	VBN
cord-000248-zueoyesj	582	6	linked	link	VBN
cord-000248-zueoyesj	582	7	at	at	IN
cord-000248-zueoyesj	582	8	10	10	CD
cord-000248-zueoyesj	582	9	different	different	JJ
cord-000248-zueoyesj	582	10	human	human	JJ
cord-000248-zueoyesj	582	11	diseases	disease	NNS
cord-000248-zueoyesj	582	12	[	[	-LRB-
cord-000248-zueoyesj	582	13	531	531	CD
cord-000248-zueoyesj	582	14	,	,	,
cord-000248-zueoyesj	582	15	532	532	CD
cord-000248-zueoyesj	582	16	]	]	-RRB-
cord-000248-zueoyesj	582	17	.	.	.
cord-000248-zueoyesj	583	1	LMNA	LMNA	NNP
cord-000248-zueoyesj	583	2	,	,	,
cord-000248-zueoyesj	583	3	due	due	IN
cord-000248-zueoyesj	583	4	to	to	IN
cord-000248-zueoyesj	583	5	its	-PRON-	PRP$
cord-000248-zueoyesj	583	6	functions	function	NNS
cord-000248-zueoyesj	583	7	,	,	,
cord-000248-zueoyesj	583	8	could	could	MD
cord-000248-zueoyesj	583	9	be	be	VB
cord-000248-zueoyesj	583	10	involved	involve	VBN
cord-000248-zueoyesj	583	11	in	in	IN
cord-000248-zueoyesj	583	12	important	important	JJ
cord-000248-zueoyesj	583	13	cell	cell	NN
cord-000248-zueoyesj	583	14	fate	fate	NN
cord-000248-zueoyesj	583	15	decisions	decision	NNS
cord-000248-zueoyesj	583	16	as	as	IN
cord-000248-zueoyesj	583	17	lamins	lamin	NNS
cord-000248-zueoyesj	583	18	are	be	VBP
cord-000248-zueoyesj	583	19	involved	involve	VBN
cord-000248-zueoyesj	583	20	in	in	IN
cord-000248-zueoyesj	583	21	the	the	DT
cord-000248-zueoyesj	583	22	organization	organization	NN
cord-000248-zueoyesj	583	23	of	of	IN
cord-000248-zueoyesj	583	24	the	the	DT
cord-000248-zueoyesj	583	25	functional	functional	JJ
cord-000248-zueoyesj	583	26	state	state	NN
cord-000248-zueoyesj	583	27	(	(	-LRB-
cord-000248-zueoyesj	583	28	and	and	CC
cord-000248-zueoyesj	583	29	position	position	NN
cord-000248-zueoyesj	583	30	)	)	-RRB-
cord-000248-zueoyesj	583	31	of	of	IN
cord-000248-zueoyesj	583	32	interphase	interphase	NN
cord-000248-zueoyesj	583	33	chromosome	chromosome	NN
cord-000248-zueoyesj	583	34	[	[	-LRB-
cord-000248-zueoyesj	583	35	531	531	CD
cord-000248-zueoyesj	583	36	]	]	-RRB-
cord-000248-zueoyesj	583	37	.	.	.
cord-000248-zueoyesj	584	1	Lamins	lamin	NNS
cord-000248-zueoyesj	584	2	are	be	VBP
cord-000248-zueoyesj	584	3	'	'	``
cord-000248-zueoyesj	584	4	'	'	``
cord-000248-zueoyesj	584	5	scaffolders	scaffolder	NNS
cord-000248-zueoyesj	584	6	'	'	''
cord-000248-zueoyesj	584	7	'	'	''
cord-000248-zueoyesj	584	8	for	for	IN
cord-000248-zueoyesj	584	9	the	the	DT
cord-000248-zueoyesj	584	10	function	function	NN
cord-000248-zueoyesj	584	11	of	of	IN
cord-000248-zueoyesj	584	12	nuclear	nuclear	JJ
cord-000248-zueoyesj	584	13	processes	process	NNS
cord-000248-zueoyesj	584	14	such	such	JJ
cord-000248-zueoyesj	584	15	as	as	IN
cord-000248-zueoyesj	584	16	chromatin	chromatin	NN
cord-000248-zueoyesj	584	17	organization	organization	NN
cord-000248-zueoyesj	584	18	,	,	,
cord-000248-zueoyesj	584	19	DNA	dna	NN
cord-000248-zueoyesj	584	20	replication	replication	NN
cord-000248-zueoyesj	584	21	,	,	,
cord-000248-zueoyesj	584	22	cellular	cellular	JJ
cord-000248-zueoyesj	584	23	integrity	integrity	NN
cord-000248-zueoyesj	584	24	and	and	CC
cord-000248-zueoyesj	584	25	transcription	transcription	NN
cord-000248-zueoyesj	584	26	[	[	-LRB-
cord-000248-zueoyesj	584	27	532	532	CD
cord-000248-zueoyesj	584	28	]	]	-RRB-
cord-000248-zueoyesj	584	29	.	.	.
cord-000248-zueoyesj	585	1	As	as	IN
cord-000248-zueoyesj	585	2	a	a	DT
cord-000248-zueoyesj	585	3	consequence	consequence	NN
cord-000248-zueoyesj	585	4	Lamins	lamin	NNS
cord-000248-zueoyesj	585	5	are	be	VBP
cord-000248-zueoyesj	585	6	involved	involve	VBN
cord-000248-zueoyesj	585	7	in	in	IN
cord-000248-zueoyesj	585	8	several	several	JJ
cord-000248-zueoyesj	585	9	clinical	clinical	JJ
cord-000248-zueoyesj	585	10	syndromes	syndrome	NNS
cord-000248-zueoyesj	585	11	[	[	-LRB-
cord-000248-zueoyesj	585	12	533	533	CD
cord-000248-zueoyesj	585	13	,	,	,
cord-000248-zueoyesj	585	14	534	534	CD
cord-000248-zueoyesj	585	15	,	,	,
cord-000248-zueoyesj	585	16	535	535	CD
cord-000248-zueoyesj	585	17	]	]	-RRB-
cord-000248-zueoyesj	585	18	.	.	.
cord-000248-zueoyesj	586	1	Among	among	IN
cord-000248-zueoyesj	586	2	the	the	DT
cord-000248-zueoyesj	586	3	recent	recent	JJ
cord-000248-zueoyesj	586	4	functions	function	NNS
cord-000248-zueoyesj	586	5	attributed	attribute	VBN
cord-000248-zueoyesj	586	6	to	to	IN
cord-000248-zueoyesj	586	7	LMNA	LMNA	NNP
cord-000248-zueoyesj	586	8	is	be	VBZ
cord-000248-zueoyesj	586	9	as	as	IN
cord-000248-zueoyesj	586	10	an	an	DT
cord-000248-zueoyesj	586	11	intrinsic	intrinsic	JJ
cord-000248-zueoyesj	586	12	modulator	modulator	NN
cord-000248-zueoyesj	586	13	of	of	IN
cord-000248-zueoyesj	586	14	ageing	age	VBG
cord-000248-zueoyesj	586	15	within	within	IN
cord-000248-zueoyesj	586	16	adult	adult	NN
cord-000248-zueoyesj	586	17	stem	stem	NN
cord-000248-zueoyesj	586	18	cells	cell	NNS
cord-000248-zueoyesj	586	19	via	via	IN
cord-000248-zueoyesj	586	20	a	a	DT
cord-000248-zueoyesj	586	21	mechanism	mechanism	NN
cord-000248-zueoyesj	586	22	where	where	WRB
cord-000248-zueoyesj	586	23	LMNA	LMNA	NNP
cord-000248-zueoyesj	586	24	act	act	NNP
cord-000248-zueoyesj	586	25	as	as	IN
cord-000248-zueoyesj	586	26	signalling	signal	VBG
cord-000248-zueoyesj	586	27	receptors	receptor	NNS
cord-000248-zueoyesj	586	28	in	in	IN
cord-000248-zueoyesj	586	29	the	the	DT
cord-000248-zueoyesj	586	30	nucleus	nucleus	NN
cord-000248-zueoyesj	586	31	.	.	.
cord-000248-zueoyesj	587	1	These	these	DT
cord-000248-zueoyesj	587	2	observations	observation	NNS
cord-000248-zueoyesj	587	3	correspond	correspond	VBP
cord-000248-zueoyesj	587	4	to	to	IN
cord-000248-zueoyesj	587	5	Pekovic	Pekovic	NNP
cord-000248-zueoyesj	587	6	and	and	CC
cord-000248-zueoyesj	587	7	Hutchinson	Hutchinson	NNP
cord-000248-zueoyesj	587	8	who	who	WP
cord-000248-zueoyesj	587	9	observed	observe	VBD
cord-000248-zueoyesj	587	10	that	that	IN
cord-000248-zueoyesj	587	11	dysfunction	dysfunction	NN
cord-000248-zueoyesj	587	12	of	of	IN
cord-000248-zueoyesj	587	13	LMNA	LMNA	NNP
cord-000248-zueoyesj	587	14	leads	lead	VBZ
cord-000248-zueoyesj	587	15	to	to	IN
cord-000248-zueoyesj	587	16	inappropriate	inappropriate	JJ
cord-000248-zueoyesj	587	17	activation	activation	NN
cord-000248-zueoyesj	587	18	of	of	IN
cord-000248-zueoyesj	587	19	self	self	NN
cord-000248-zueoyesj	587	20	-	-	HYPH
cord-000248-zueoyesj	587	21	renewal	renewal	NN
cord-000248-zueoyesj	587	22	pathways	pathway	NNS
cord-000248-zueoyesj	587	23	and	and	CC
cord-000248-zueoyesj	587	24	initiation	initiation	NN
cord-000248-zueoyesj	587	25	of	of	IN
cord-000248-zueoyesj	587	26	stress	stress	NN
cord-000248-zueoyesj	587	27	-	-	HYPH
cord-000248-zueoyesj	587	28	induced	induce	VBN
cord-000248-zueoyesj	587	29	senescense	senescense	NN
cord-000248-zueoyesj	587	30	[	[	-LRB-
cord-000248-zueoyesj	587	31	536	536	CD
cord-000248-zueoyesj	587	32	]	]	-RRB-
cord-000248-zueoyesj	587	33	.	.	.
cord-000248-zueoyesj	588	1	In	in	IN
cord-000248-zueoyesj	588	2	lmna	lmna	NN
cord-000248-zueoyesj	588	3	-	-	HYPH
cord-000248-zueoyesj	588	4	deficient	deficient	JJ
cord-000248-zueoyesj	588	5	mouse	mouse	NN
cord-000248-zueoyesj	588	6	embryonic	embryonic	JJ
cord-000248-zueoyesj	588	7	fibroblasts	fibroblast	NNS
cord-000248-zueoyesj	588	8	(	(	-LRB-
cord-000248-zueoyesj	588	9	lmna(2/2	lmna(2/2	VBN
cord-000248-zueoyesj	588	10	)	)	-RRB-
cord-000248-zueoyesj	588	11	MEFs	MEFs	NNP
cord-000248-zueoyesj	588	12	)	)	-RRB-
cord-000248-zueoyesj	588	13	,	,	,
cord-000248-zueoyesj	588	14	the	the	DT
cord-000248-zueoyesj	588	15	loss	loss	NN
cord-000248-zueoyesj	588	16	of	of	IN
cord-000248-zueoyesj	588	17	lmna''dramatically	lmna''dramatically	RB
cord-000248-zueoyesj	588	18	affects	affect	VBZ
cord-000248-zueoyesj	588	19	the	the	DT
cord-000248-zueoyesj	588	20	micromechanical	micromechanical	JJ
cord-000248-zueoyesj	588	21	properties	property	NNS
cord-000248-zueoyesj	588	22	of	of	IN
cord-000248-zueoyesj	588	23	the	the	DT
cord-000248-zueoyesj	588	24	cytoplasm	cytoplasm	NN
cord-000248-zueoyesj	588	25	'	'	''
cord-000248-zueoyesj	588	26	'	'	''
cord-000248-zueoyesj	588	27	,	,	,
cord-000248-zueoyesj	588	28	since	since	IN
cord-000248-zueoyesj	588	29	'	'	''
cord-000248-zueoyesj	588	30	'	'	''
cord-000248-zueoyesj	588	31	Both	both	CC
cord-000248-zueoyesj	588	32	the	the	DT
cord-000248-zueoyesj	588	33	elasticity	elasticity	NN
cord-000248-zueoyesj	588	34	(	(	-LRB-
cord-000248-zueoyesj	588	35	stretchiness	stretchiness	NN
cord-000248-zueoyesj	588	36	)	)	-RRB-
cord-000248-zueoyesj	588	37	and	and	CC
cord-000248-zueoyesj	588	38	the	the	DT
cord-000248-zueoyesj	588	39	viscosity	viscosity	NN
cord-000248-zueoyesj	588	40	(	(	-LRB-
cord-000248-zueoyesj	588	41	propensity	propensity	NN
cord-000248-zueoyesj	588	42	of	of	IN
cord-000248-zueoyesj	588	43	a	a	DT
cord-000248-zueoyesj	588	44	material	material	NN
cord-000248-zueoyesj	588	45	to	to	TO
cord-000248-zueoyesj	588	46	flow	flow	VB
cord-000248-zueoyesj	588	47	)	)	-RRB-
cord-000248-zueoyesj	588	48	of	of	IN
cord-000248-zueoyesj	588	49	the	the	DT
cord-000248-zueoyesj	588	50	cytoplasm	cytoplasm	NN
cord-000248-zueoyesj	588	51	in	in	IN
cord-000248-zueoyesj	588	52	Lmna(2/2	Lmna(2/2	NNP
cord-000248-zueoyesj	588	53	)	)	-RRB-
cord-000248-zueoyesj	588	54	MEFs	mef	NNS
cord-000248-zueoyesj	588	55	are	be	VBP
cord-000248-zueoyesj	588	56	significantly	significantly	RB
cord-000248-zueoyesj	588	57	reduced	reduce	VBN
cord-000248-zueoyesj	588	58	'	'	''
cord-000248-zueoyesj	588	59	'	'	''
cord-000248-zueoyesj	588	60	[	[	-LRB-
cord-000248-zueoyesj	588	61	537	537	CD
cord-000248-zueoyesj	588	62	]	]	-RRB-
cord-000248-zueoyesj	588	63	.	.	.
cord-000248-zueoyesj	589	1	Using	use	VBG
cord-000248-zueoyesj	589	2	ballistic	ballistic	JJ
cord-000248-zueoyesj	589	3	intracellular	intracellular	JJ
cord-000248-zueoyesj	589	4	nanorheology	nanorheology	NN
cord-000248-zueoyesj	589	5	to	to	TO
cord-000248-zueoyesj	589	6	evaluate	evaluate	VB
cord-000248-zueoyesj	589	7	the	the	DT
cord-000248-zueoyesj	589	8	micromechanical	micromechanical	JJ
cord-000248-zueoyesj	589	9	properties	property	NNS
cord-000248-zueoyesj	589	10	of	of	IN
cord-000248-zueoyesj	589	11	the	the	DT
cord-000248-zueoyesj	589	12	cytoplasm	cytoplasm	NN
cord-000248-zueoyesj	589	13	of	of	IN
cord-000248-zueoyesj	589	14	these	these	DT
cord-000248-zueoyesj	589	15	cells	cell	NNS
cord-000248-zueoyesj	589	16	,	,	,
cord-000248-zueoyesj	589	17	Lee	Lee	NNP
cord-000248-zueoyesj	589	18	et	et	NNP
cord-000248-zueoyesj	589	19	al	al	NNP
cord-000248-zueoyesj	589	20	.	.	.
cord-000248-zueoyesj	590	1	conclude	conclude	VB
cord-000248-zueoyesj	590	2	:	:	:
cord-000248-zueoyesj	590	3	''	''	''
cord-000248-zueoyesj	591	1	Together	together	RB
cord-000248-zueoyesj	591	2	these	these	DT
cord-000248-zueoyesj	591	3	results	result	NNS
cord-000248-zueoyesj	591	4	show	show	VBP
cord-000248-zueoyesj	591	5	that	that	IN
cord-000248-zueoyesj	591	6	both	both	CC
cord-000248-zueoyesj	591	7	the	the	DT
cord-000248-zueoyesj	591	8	mechanical	mechanical	JJ
cord-000248-zueoyesj	591	9	properties	property	NNS
cord-000248-zueoyesj	591	10	of	of	IN
cord-000248-zueoyesj	591	11	the	the	DT
cord-000248-zueoyesj	591	12	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	591	13	and	and	CC
cord-000248-zueoyesj	591	14	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	591	15	-	-	HYPH
cord-000248-zueoyesj	591	16	based	base	VBN
cord-000248-zueoyesj	591	17	processes	process	NNS
cord-000248-zueoyesj	591	18	,	,	,
cord-000248-zueoyesj	591	19	including	include	VBG
cord-000248-zueoyesj	591	20	cell	cell	NN
cord-000248-zueoyesj	591	21	motility	motility	NN
cord-000248-zueoyesj	591	22	,	,	,
cord-000248-zueoyesj	591	23	coupled	couple	VBN
cord-000248-zueoyesj	591	24	MTOC	MTOC	NNP
cord-000248-zueoyesj	591	25	and	and	CC
cord-000248-zueoyesj	591	26	nucleus	nucleus	NN
cord-000248-zueoyesj	591	27	dynamics	dynamic	NNS
cord-000248-zueoyesj	591	28	,	,	,
cord-000248-zueoyesj	591	29	and	and	CC
cord-000248-zueoyesj	591	30	cell	cell	NN
cord-000248-zueoyesj	591	31	polarization	polarization	NN
cord-000248-zueoyesj	591	32	,	,	,
cord-000248-zueoyesj	591	33	depend	depend	VB
cord-000248-zueoyesj	591	34	critically	critically	RB
cord-000248-zueoyesj	591	35	on	on	IN
cord-000248-zueoyesj	591	36	the	the	DT
cord-000248-zueoyesj	591	37	integrity	integrity	NN
cord-000248-zueoyesj	591	38	of	of	IN
cord-000248-zueoyesj	591	39	the	the	DT
cord-000248-zueoyesj	591	40	nuclear	nuclear	JJ
cord-000248-zueoyesj	591	41	lamina	lamina	NN
cord-000248-zueoyesj	591	42	,	,	,
cord-000248-zueoyesj	591	43	which	which	WDT
cord-000248-zueoyesj	591	44	suggest	suggest	VBP
cord-000248-zueoyesj	591	45	the	the	DT
cord-000248-zueoyesj	591	46	existence	existence	NN
cord-000248-zueoyesj	591	47	of	of	IN
cord-000248-zueoyesj	591	48	a	a	DT
cord-000248-zueoyesj	591	49	functional	functional	JJ
cord-000248-zueoyesj	591	50	mechanical	mechanical	JJ
cord-000248-zueoyesj	591	51	connection	connection	NN
cord-000248-zueoyesj	591	52	between	between	IN
cord-000248-zueoyesj	591	53	the	the	DT
cord-000248-zueoyesj	591	54	nucleus	nucleus	NN
cord-000248-zueoyesj	591	55	and	and	CC
cord-000248-zueoyesj	591	56	the	the	DT
cord-000248-zueoyesj	591	57	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	591	58	.	.	.
cord-000248-zueoyesj	592	1	These	these	DT
cord-000248-zueoyesj	592	2	results	result	NNS
cord-000248-zueoyesj	592	3	also	also	RB
cord-000248-zueoyesj	592	4	suggest	suggest	VBP
cord-000248-zueoyesj	592	5	that	that	IN
cord-000248-zueoyesj	592	6	cell	cell	NN
cord-000248-zueoyesj	592	7	polarization	polarization	NN
cord-000248-zueoyesj	592	8	during	during	IN
cord-000248-zueoyesj	592	9	cell	cell	NN
cord-000248-zueoyesj	592	10	migration	migration	NN
cord-000248-zueoyesj	592	11	requires	require	VBZ
cord-000248-zueoyesj	592	12	tight	tight	JJ
cord-000248-zueoyesj	592	13	mechanical	mechanical	JJ
cord-000248-zueoyesj	592	14	coupling	coupling	NN
cord-000248-zueoyesj	592	15	between	between	IN
cord-000248-zueoyesj	592	16	MTOC	MTOC	NNP
cord-000248-zueoyesj	592	17	and	and	CC
cord-000248-zueoyesj	592	18	nucleus	nucleus	NN
cord-000248-zueoyesj	592	19	,	,	,
cord-000248-zueoyesj	592	20	which	which	WDT
cord-000248-zueoyesj	592	21	is	be	VBZ
cord-000248-zueoyesj	592	22	mediated	mediate	VBN
cord-000248-zueoyesj	592	23	by	by	IN
cord-000248-zueoyesj	592	24	lamin	lamin	NNP
cord-000248-zueoyesj	592	25	A	A	NNP
cord-000248-zueoyesj	592	26	/	/	SYM
cord-000248-zueoyesj	592	27	C	C	NNP
cord-000248-zueoyesj	592	28	'	'	''
cord-000248-zueoyesj	592	29	'	'	''
cord-000248-zueoyesj	592	30	[	[	-LRB-
cord-000248-zueoyesj	592	31	537	537	CD
cord-000248-zueoyesj	592	32	]	]	-RRB-
cord-000248-zueoyesj	592	33	(	(	-LRB-
cord-000248-zueoyesj	592	34	see	see	VB
cord-000248-zueoyesj	592	35	also	also	RB
cord-000248-zueoyesj	592	36	[	[	-LRB-
cord-000248-zueoyesj	592	37	538	538	CD
cord-000248-zueoyesj	592	38	,	,	,
cord-000248-zueoyesj	592	39	539	539	CD
cord-000248-zueoyesj	592	40	]	]	-RRB-
cord-000248-zueoyesj	592	41	)	)	-RRB-
cord-000248-zueoyesj	592	42	.	.	.
cord-000248-zueoyesj	593	1	In	in	IN
cord-000248-zueoyesj	593	2	addition	addition	NN
cord-000248-zueoyesj	593	3	to	to	IN
cord-000248-zueoyesj	593	4	these	these	DT
cord-000248-zueoyesj	593	5	very	very	RB
cord-000248-zueoyesj	593	6	interesting	interesting	JJ
cord-000248-zueoyesj	593	7	findings	finding	NNS
cord-000248-zueoyesj	593	8	,	,	,
cord-000248-zueoyesj	593	9	a	a	DT
cord-000248-zueoyesj	593	10	functional	functional	JJ
cord-000248-zueoyesj	593	11	association	association	NN
cord-000248-zueoyesj	593	12	of	of	IN
cord-000248-zueoyesj	593	13	LMNA	LMNA	NNP
cord-000248-zueoyesj	593	14	and	and	CC
cord-000248-zueoyesj	593	15	the	the	DT
cord-000248-zueoyesj	593	16	retinoblastoma	retinoblastoma	NN
cord-000248-zueoyesj	593	17	protein	protein	NN
cord-000248-zueoyesj	593	18	(	(	-LRB-
cord-000248-zueoyesj	593	19	pRB	pRB	NNP
cord-000248-zueoyesj	593	20	)	)	-RRB-
cord-000248-zueoyesj	593	21	exists	exist	VBZ
cord-000248-zueoyesj	593	22	.	.	.
cord-000248-zueoyesj	594	1	Nitta	Nitta	NNP
cord-000248-zueoyesj	594	2	et	et	NNP
cord-000248-zueoyesj	594	3	al	al	NNP
cord-000248-zueoyesj	594	4	.	.	NNP
cord-000248-zueoyesj	594	5	have	have	VBP
cord-000248-zueoyesj	594	6	shown	show	VBN
cord-000248-zueoyesj	594	7	that	that	IN
cord-000248-zueoyesj	594	8	pRB	prb	NN
cord-000248-zueoyesj	594	9	needs	need	VBZ
cord-000248-zueoyesj	594	10	to	to	TO
cord-000248-zueoyesj	594	11	be	be	VB
cord-000248-zueoyesj	594	12	stabilized	stabilize	VBN
cord-000248-zueoyesj	594	13	by	by	IN
cord-000248-zueoyesj	594	14	LMNA	LMNA	NNP
cord-000248-zueoyesj	594	15	for	for	IN
cord-000248-zueoyesj	594	16	INK4A	INK4A	NNP
cord-000248-zueoyesj	594	17	-	-	HYPH
cord-000248-zueoyesj	594	18	mediated	mediate	VBN
cord-000248-zueoyesj	594	19	cell	cell	NN
cord-000248-zueoyesj	594	20	cycle	cycle	NN
cord-000248-zueoyesj	594	21	arrest	arrest	NN
cord-000248-zueoyesj	594	22	and	and	CC
cord-000248-zueoyesj	594	23	that	that	IN
cord-000248-zueoyesj	594	24	somatic	somatic	JJ
cord-000248-zueoyesj	594	25	mutations	mutation	NNS
cord-000248-zueoyesj	594	26	in	in	IN
cord-000248-zueoyesj	594	27	LMNA	LMNA	NNP
cord-000248-zueoyesj	594	28	may	may	MD
cord-000248-zueoyesj	594	29	also	also	RB
cord-000248-zueoyesj	594	30	have	have	VB
cord-000248-zueoyesj	594	31	a	a	DT
cord-000248-zueoyesj	594	32	role	role	NN
cord-000248-zueoyesj	594	33	in	in	IN
cord-000248-zueoyesj	594	34	tumor	tumor	NN
cord-000248-zueoyesj	594	35	progression	progression	NN
cord-000248-zueoyesj	594	36	[	[	-LRB-
cord-000248-zueoyesj	594	37	540	540	CD
cord-000248-zueoyesj	594	38	]	]	-RRB-
cord-000248-zueoyesj	594	39	.	.	.
cord-000248-zueoyesj	595	1	In	in	IN
cord-000248-zueoyesj	595	2	mammalian	mammalian	JJ
cord-000248-zueoyesj	595	3	cells	cell	NNS
cord-000248-zueoyesj	595	4	,	,	,
cord-000248-zueoyesj	595	5	LMNA	LMNA	NNP
cord-000248-zueoyesj	595	6	a	a	LS
cord-000248-zueoyesj	595	7	)	)	-RRB-
cord-000248-zueoyesj	595	8	colocalizes	colocalizes	NNP
cord-000248-zueoyesj	595	9	with	with	IN
cord-000248-zueoyesj	595	10	c	c	NNP
cord-000248-zueoyesj	595	11	-	-	HYPH
cord-000248-zueoyesj	595	12	FOS	FOS	NNP
cord-000248-zueoyesj	595	13	at	at	IN
cord-000248-zueoyesj	595	14	the	the	DT
cord-000248-zueoyesj	595	15	nuclear	nuclear	JJ
cord-000248-zueoyesj	595	16	envelope	envelope	NN
cord-000248-zueoyesj	595	17	,	,	,
cord-000248-zueoyesj	595	18	b	b	LS
cord-000248-zueoyesj	595	19	)	)	-RRB-
cord-000248-zueoyesj	595	20	suppresses	suppress	VBZ
cord-000248-zueoyesj	595	21	AP-1	AP-1	NNP
cord-000248-zueoyesj	595	22	through	through	IN
cord-000248-zueoyesj	595	23	a	a	DT
cord-000248-zueoyesj	595	24	direct	direct	JJ
cord-000248-zueoyesj	595	25	interaction	interaction	NN
cord-000248-zueoyesj	595	26	with	with	IN
cord-000248-zueoyesj	595	27	c	c	NN
cord-000248-zueoyesj	595	28	-	-	:
cord-000248-zueoyesj	595	29	FOS	FOS	NNP
cord-000248-zueoyesj	595	30	and	and	CC
cord-000248-zueoyesj	595	31	,	,	,
cord-000248-zueoyesj	595	32	in	in	IN
cord-000248-zueoyesj	595	33	LMNA	LMNA	NNP
cord-000248-zueoyesj	595	34	-	-	HYPH
cord-000248-zueoyesj	595	35	null	null	NN
cord-000248-zueoyesj	595	36	cells	cell	NNS
cord-000248-zueoyesj	595	37	perinuclear	perinuclear	NNP
cord-000248-zueoyesj	595	38	localization	localization	NN
cord-000248-zueoyesj	595	39	of	of	IN
cord-000248-zueoyesj	595	40	c	c	NNP
cord-000248-zueoyesj	595	41	-	-	:
cord-000248-zueoyesj	595	42	FOS	FOS	NNP
cord-000248-zueoyesj	595	43	is	be	VBZ
cord-000248-zueoyesj	595	44	absent	absent	JJ
cord-000248-zueoyesj	596	1	(	(	-LRB-
cord-000248-zueoyesj	596	2	but	but	CC
cord-000248-zueoyesj	596	3	it	-PRON-	PRP
cord-000248-zueoyesj	596	4	is	be	VBZ
cord-000248-zueoyesj	596	5	restored	restore	VBN
cord-000248-zueoyesj	596	6	when	when	WRB
cord-000248-zueoyesj	596	7	it	-PRON-	PRP
cord-000248-zueoyesj	596	8	is	be	VBZ
cord-000248-zueoyesj	596	9	overexpressed	overexpresse	VBN
cord-000248-zueoyesj	597	1	,	,	,
cord-000248-zueoyesj	597	2	c	c	LS
cord-000248-zueoyesj	597	3	)	)	-RRB-
cord-000248-zueoyesj	597	4	LMNA	LMNA	NNP
cord-000248-zueoyesj	597	5	-	-	HYPH
cord-000248-zueoyesj	597	6	null	null	NN
cord-000248-zueoyesj	597	7	cells	cell	NNS
cord-000248-zueoyesj	597	8	have	have	VBP
cord-000248-zueoyesj	597	9	enhanced	enhance	VBN
cord-000248-zueoyesj	597	10	proliferation	proliferation	NN
cord-000248-zueoyesj	597	11	[	[	-LRB-
cord-000248-zueoyesj	597	12	74	74	CD
cord-000248-zueoyesj	597	13	]	]	-RRB-
cord-000248-zueoyesj	597	14	.	.	.
cord-000248-zueoyesj	598	1	These	these	DT
cord-000248-zueoyesj	598	2	results	result	NNS
cord-000248-zueoyesj	598	3	obtained	obtain	VBN
cord-000248-zueoyesj	598	4	by	by	IN
cord-000248-zueoyesj	598	5	Ivorra	Ivorra	NNP
cord-000248-zueoyesj	598	6	et	et	NNP
cord-000248-zueoyesj	598	7	al	al	NNP
cord-000248-zueoyesj	598	8	.	.	NNP
cord-000248-zueoyesj	598	9	are	be	VBP
cord-000248-zueoyesj	598	10	giving	give	VBG
cord-000248-zueoyesj	598	11	the	the	DT
cord-000248-zueoyesj	598	12	indication	indication	NN
cord-000248-zueoyesj	598	13	that	that	IN
cord-000248-zueoyesj	598	14	of	of	IN
cord-000248-zueoyesj	598	15	yet	yet	RB
cord-000248-zueoyesj	598	16	another	another	DT
cord-000248-zueoyesj	598	17	mechanism	mechanism	NN
cord-000248-zueoyesj	598	18	of	of	IN
cord-000248-zueoyesj	598	19	cell	cell	NN
cord-000248-zueoyesj	598	20	cycle	cycle	NN
cord-000248-zueoyesj	598	21	and	and	CC
cord-000248-zueoyesj	598	22	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	598	23	control	control	NN
cord-000248-zueoyesj	598	24	mediated	mediate	VBN
cord-000248-zueoyesj	598	25	by	by	IN
cord-000248-zueoyesj	598	26	LMNA	LMNA	NNP
cord-000248-zueoyesj	598	27	[	[	-LRB-
cord-000248-zueoyesj	598	28	74	74	CD
cord-000248-zueoyesj	598	29	]	]	-RRB-
cord-000248-zueoyesj	598	30	(	(	-LRB-
cord-000248-zueoyesj	598	31	see	see	VB
cord-000248-zueoyesj	598	32	also	also	RB
cord-000248-zueoyesj	598	33	[	[	-LRB-
cord-000248-zueoyesj	598	34	541	541	CD
cord-000248-zueoyesj	598	35	]	]	-RRB-
cord-000248-zueoyesj	598	36	)	)	-RRB-
cord-000248-zueoyesj	598	37	.	.	.
cord-000248-zueoyesj	599	1	LMNA	LMNA	NNP
cord-000248-zueoyesj	599	2	has	have	VBZ
cord-000248-zueoyesj	599	3	also	also	RB
cord-000248-zueoyesj	599	4	been	be	VBN
cord-000248-zueoyesj	599	5	proposed	propose	VBN
cord-000248-zueoyesj	599	6	as	as	IN
cord-000248-zueoyesj	599	7	an	an	DT
cord-000248-zueoyesj	599	8	inhibitor	inhibitor	NN
cord-000248-zueoyesj	599	9	of	of	IN
cord-000248-zueoyesj	599	10	adipocyte	adipocyte	JJ
cord-000248-zueoyesj	599	11	differentiation	differentiation	NN
cord-000248-zueoyesj	599	12	[	[	-LRB-
cord-000248-zueoyesj	599	13	542	542	CD
cord-000248-zueoyesj	599	14	]	]	-RRB-
cord-000248-zueoyesj	599	15	.	.	.
cord-000248-zueoyesj	600	1	Hutchingson	Hutchingson	NNP
cord-000248-zueoyesj	600	2	et	et	NNP
cord-000248-zueoyesj	600	3	al	al	NNP
cord-000248-zueoyesj	600	4	.	.	NNP
cord-000248-zueoyesj	600	5	have	have	VBP
cord-000248-zueoyesj	600	6	proposed	propose	VBN
cord-000248-zueoyesj	600	7	the	the	DT
cord-000248-zueoyesj	600	8	alias	alias	NN
cord-000248-zueoyesj	600	9	of	of	IN
cord-000248-zueoyesj	600	10	'	'	``
cord-000248-zueoyesj	600	11	'	'	''
cord-000248-zueoyesj	600	12	guardian	guardian	NN
cord-000248-zueoyesj	600	13	of	of	IN
cord-000248-zueoyesj	600	14	the	the	DT
cord-000248-zueoyesj	600	15	soma	soma	NNP
cord-000248-zueoyesj	600	16	'	'	''
cord-000248-zueoyesj	600	17	'	'	''
cord-000248-zueoyesj	600	18	for	for	IN
cord-000248-zueoyesj	600	19	lamins	lamins	NNPS
cord-000248-zueoyesj	600	20	A	A	NNP
cord-000248-zueoyesj	600	21	and	and	CC
cord-000248-zueoyesj	600	22	C	C	NNP
cord-000248-zueoyesj	600	23	as	as	IN
cord-000248-zueoyesj	600	24	they	-PRON-	PRP
cord-000248-zueoyesj	600	25	seem	seem	VBP
cord-000248-zueoyesj	600	26	to	to	TO
cord-000248-zueoyesj	600	27	have	have	VB
cord-000248-zueoyesj	600	28	'	'	``
cord-000248-zueoyesj	600	29	'	'	``
cord-000248-zueoyesj	600	30	essential	essential	JJ
cord-000248-zueoyesj	600	31	functions	function	NNS
cord-000248-zueoyesj	600	32	in	in	IN
cord-000248-zueoyesj	600	33	protecting	protect	VBG
cord-000248-zueoyesj	600	34	cells	cell	NNS
cord-000248-zueoyesj	600	35	from	from	IN
cord-000248-zueoyesj	600	36	physical	physical	JJ
cord-000248-zueoyesj	600	37	damage	damage	NN
cord-000248-zueoyesj	600	38	,	,	,
cord-000248-zueoyesj	600	39	as	as	RB
cord-000248-zueoyesj	600	40	well	well	RB
cord-000248-zueoyesj	600	41	as	as	IN
cord-000248-zueoyesj	600	42	in	in	IN
cord-000248-zueoyesj	600	43	maintaining	maintain	VBG
cord-000248-zueoyesj	600	44	the	the	DT
cord-000248-zueoyesj	600	45	function	function	NN
cord-000248-zueoyesj	600	46	of	of	IN
cord-000248-zueoyesj	600	47	transcription	transcription	NN
cord-000248-zueoyesj	600	48	factors	factor	NNS
cord-000248-zueoyesj	600	49	required	require	VBN
cord-000248-zueoyesj	600	50	for	for	IN
cord-000248-zueoyesj	600	51	the	the	DT
cord-000248-zueoyesj	600	52	differentiation	differentiation	NN
cord-000248-zueoyesj	600	53	of	of	IN
cord-000248-zueoyesj	600	54	adult	adult	NN
cord-000248-zueoyesj	600	55	stem	stem	NN
cord-000248-zueoyesj	600	56	cells	cell	NNS
cord-000248-zueoyesj	600	57	'	'	POS
cord-000248-zueoyesj	600	58	'	'	''
cord-000248-zueoyesj	600	59	[	[	-LRB-
cord-000248-zueoyesj	600	60	543	543	CD
cord-000248-zueoyesj	600	61	]	]	-RRB-
cord-000248-zueoyesj	600	62	.	.	.
cord-000248-zueoyesj	601	1	From	from	IN
cord-000248-zueoyesj	601	2	our	-PRON-	PRP$
cord-000248-zueoyesj	601	3	results	result	NNS
cord-000248-zueoyesj	601	4	,	,	,
cord-000248-zueoyesj	601	5	we	-PRON-	PRP
cord-000248-zueoyesj	601	6	can	can	MD
cord-000248-zueoyesj	601	7	not	not	RB
cord-000248-zueoyesj	601	8	completely	completely	RB
cord-000248-zueoyesj	601	9	establish	establish	VB
cord-000248-zueoyesj	601	10	if	if	IN
cord-000248-zueoyesj	601	11	the	the	DT
cord-000248-zueoyesj	601	12	downregulation	downregulation	NN
cord-000248-zueoyesj	601	13	of	of	IN
cord-000248-zueoyesj	601	14	CD40	CD40	NNP
cord-000248-zueoyesj	601	15	and	and	CC
cord-000248-zueoyesj	601	16	CD59	CD59	NNP
cord-000248-zueoyesj	601	17	are	be	VBP
cord-000248-zueoyesj	601	18	enough	enough	JJ
cord-000248-zueoyesj	601	19	to	to	TO
cord-000248-zueoyesj	601	20	pinpoint	pinpoint	VB
cord-000248-zueoyesj	601	21	an	an	DT
cord-000248-zueoyesj	601	22	impaired	impaired	JJ
cord-000248-zueoyesj	601	23	or	or	CC
cord-000248-zueoyesj	601	24	abnormal	abnormal	JJ
cord-000248-zueoyesj	601	25	immune	immune	JJ
cord-000248-zueoyesj	601	26	response	response	NN
cord-000248-zueoyesj	601	27	.	.	.
cord-000248-zueoyesj	602	1	If	if	IN
cord-000248-zueoyesj	602	2	we	-PRON-	PRP
cord-000248-zueoyesj	602	3	continue	continue	VBP
cord-000248-zueoyesj	602	4	the	the	DT
cord-000248-zueoyesj	602	5	inspection	inspection	NN
cord-000248-zueoyesj	602	6	of	of	IN
cord-000248-zueoyesj	602	7	the	the	DT
cord-000248-zueoyesj	602	8	list	list	NN
cord-000248-zueoyesj	602	9	,	,	,
cord-000248-zueoyesj	602	10	the	the	DT
cord-000248-zueoyesj	602	11	first	first	JJ
cord-000248-zueoyesj	602	12	20	20	CD
cord-000248-zueoyesj	602	13	probes	probe	NNS
cord-000248-zueoyesj	602	14	give	give	VBP
cord-000248-zueoyesj	602	15	us	-PRON-	PRP
cord-000248-zueoyesj	602	16	more	more	RBR
cord-000248-zueoyesj	602	17	supporting	supporting	JJ
cord-000248-zueoyesj	602	18	evidence	evidence	NN
cord-000248-zueoyesj	602	19	.	.	.
cord-000248-zueoyesj	603	1	The	the	DT
cord-000248-zueoyesj	603	2	20	20	CD
cord-000248-zueoyesj	603	3	probes	probe	NNS
cord-000248-zueoyesj	603	4	correspond	correspond	VBP
cord-000248-zueoyesj	603	5	to	to	IN
cord-000248-zueoyesj	603	6	13	13	CD
cord-000248-zueoyesj	603	7	different	different	JJ
cord-000248-zueoyesj	603	8	genes	gene	NNS
cord-000248-zueoyesj	603	9	.	.	.
cord-000248-zueoyesj	604	1	Five	five	CD
cord-000248-zueoyesj	604	2	of	of	IN
cord-000248-zueoyesj	604	3	these	these	DT
cord-000248-zueoyesj	604	4	13	13	CD
cord-000248-zueoyesj	604	5	genes	gene	NNS
cord-000248-zueoyesj	604	6	have	have	VBP
cord-000248-zueoyesj	604	7	Genome	Genome	NNP
cord-000248-zueoyesj	604	8	Ontology	Ontology	NNP
cord-000248-zueoyesj	604	9	information	information	NN
cord-000248-zueoyesj	604	10	annotated	annotate	VBN
cord-000248-zueoyesj	604	11	as	as	IN
cord-000248-zueoyesj	604	12	'	'	''
cord-000248-zueoyesj	604	13	'	'	''
cord-000248-zueoyesj	604	14	defense	defense	NN
cord-000248-zueoyesj	604	15	response	response	NN
cord-000248-zueoyesj	604	16	'	'	''
cord-000248-zueoyesj	604	17	'	'	''
cord-000248-zueoyesj	604	18	,	,	,
cord-000248-zueoyesj	604	19	the	the	DT
cord-000248-zueoyesj	604	20	above	above	RB
cord-000248-zueoyesj	604	21	mentioned	mention	VBD
cord-000248-zueoyesj	604	22	CD59	CD59	NNP
cord-000248-zueoyesj	604	23	and	and	CC
cord-000248-zueoyesj	604	24	CD40	CD40	NNP
cord-000248-zueoyesj	604	25	as	as	RB
cord-000248-zueoyesj	604	26	well	well	RB
cord-000248-zueoyesj	604	27	as	as	IN
cord-000248-zueoyesj	604	28	IL4R	il4r	NN
cord-000248-zueoyesj	604	29	(	(	-LRB-
cord-000248-zueoyesj	604	30	interleukin	interleukin	NN
cord-000248-zueoyesj	604	31	4	4	CD
cord-000248-zueoyesj	604	32	receptor	receptor	NN
cord-000248-zueoyesj	604	33	,	,	,
cord-000248-zueoyesj	604	34	CR616481	CR616481	NNP
cord-000248-zueoyesj	604	35	)	)	-RRB-
cord-000248-zueoyesj	604	36	,	,	.
cord-000248-zueoyesj	605	1	XBP1	XBP1	NNP
cord-000248-zueoyesj	605	2	(	(	-LRB-
cord-000248-zueoyesj	605	3	X	x	NN
cord-000248-zueoyesj	605	4	-	-	HYPH
cord-000248-zueoyesj	605	5	box	box	NN
cord-000248-zueoyesj	605	6	binding	bind	VBG
cord-000248-zueoyesj	605	7	protein	protein	NN
cord-000248-zueoyesj	605	8	1	1	CD
cord-000248-zueoyesj	605	9	,	,	,
cord-000248-zueoyesj	605	10	AK093842	ak093842	NN
cord-000248-zueoyesj	605	11	)	)	-RRB-
cord-000248-zueoyesj	605	12	and	and	CC
cord-000248-zueoyesj	605	13	HLA	HLA	NNP
cord-000248-zueoyesj	605	14	-	-	HYPH
cord-000248-zueoyesj	605	15	A	A	NNP
cord-000248-zueoyesj	605	16	(	(	-LRB-
cord-000248-zueoyesj	605	17	major	major	JJ
cord-000248-zueoyesj	605	18	histocompatibility	histocompatibility	NN
cord-000248-zueoyesj	605	19	complex	complex	JJ
cord-000248-zueoyesj	605	20	class	class	NN
cord-000248-zueoyesj	606	1	I	-PRON-	PRP
cord-000248-zueoyesj	606	2	HLA	HLA	NNP
cord-000248-zueoyesj	606	3	-	-	HYPH
cord-000248-zueoyesj	606	4	A29.1	A29.1	NNP
cord-000248-zueoyesj	606	5	,	,	,
cord-000248-zueoyesj	606	6	BU075230	BU075230	NNP
cord-000248-zueoyesj	606	7	)	)	-RRB-
cord-000248-zueoyesj	606	8	.	.	.
cord-000248-zueoyesj	607	1	Takahashi	Takahashi	NNP
cord-000248-zueoyesj	607	2	et	et	NNP
cord-000248-zueoyesj	607	3	al	al	NNP
cord-000248-zueoyesj	607	4	.	.	.
cord-000248-zueoyesj	608	1	[	[	-LRB-
cord-000248-zueoyesj	608	2	544	544	CD
cord-000248-zueoyesj	608	3	]	]	-RRB-
cord-000248-zueoyesj	608	4	report	report	VBP
cord-000248-zueoyesj	608	5	an	an	DT
cord-000248-zueoyesj	608	6	inverse	inverse	JJ
cord-000248-zueoyesj	608	7	correlation	correlation	NN
cord-000248-zueoyesj	608	8	between	between	IN
cord-000248-zueoyesj	608	9	XBP1	XBP1	NNP
cord-000248-zueoyesj	608	10	expression	expression	NN
cord-000248-zueoyesj	608	11	and	and	CC
cord-000248-zueoyesj	608	12	histological	histological	JJ
cord-000248-zueoyesj	608	13	differentiation	differentiation	NN
cord-000248-zueoyesj	608	14	in	in	IN
cord-000248-zueoyesj	608	15	a	a	DT
cord-000248-zueoyesj	608	16	series	series	NN
cord-000248-zueoyesj	608	17	of	of	IN
cord-000248-zueoyesj	608	18	prostate	prostate	NN
cord-000248-zueoyesj	608	19	cancers	cancer	NNS
cord-000248-zueoyesj	608	20	without	without	IN
cord-000248-zueoyesj	608	21	hormonal	hormonal	JJ
cord-000248-zueoyesj	608	22	therapy	therapy	NN
cord-000248-zueoyesj	608	23	,	,	,
cord-000248-zueoyesj	608	24	the	the	DT
cord-000248-zueoyesj	608	25	expression	expression	NN
cord-000248-zueoyesj	608	26	of	of	IN
cord-000248-zueoyesj	608	27	XBP1	XBP1	NNP
cord-000248-zueoyesj	608	28	was	be	VBD
cord-000248-zueoyesj	608	29	localized	localize	VBN
cord-000248-zueoyesj	608	30	in	in	IN
cord-000248-zueoyesj	608	31	epithelial	epithelial	JJ
cord-000248-zueoyesj	608	32	and	and	CC
cord-000248-zueoyesj	608	33	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	608	34	cells	cell	NNS
cord-000248-zueoyesj	608	35	of	of	IN
cord-000248-zueoyesj	608	36	the	the	DT
cord-000248-zueoyesj	608	37	prostate	prostate	NN
cord-000248-zueoyesj	608	38	and	and	CC
cord-000248-zueoyesj	608	39	the	the	DT
cord-000248-zueoyesj	608	40	majority	majority	NN
cord-000248-zueoyesj	608	41	of	of	IN
cord-000248-zueoyesj	608	42	refractory	refractory	JJ
cord-000248-zueoyesj	608	43	cancer	cancer	NN
cord-000248-zueoyesj	608	44	cases	case	NNS
cord-000248-zueoyesj	608	45	exhibited	exhibit	VBD
cord-000248-zueoyesj	608	46	weak	weak	JJ
cord-000248-zueoyesj	608	47	XBP1	XBP1	NNP
cord-000248-zueoyesj	608	48	expression	expression	NN
cord-000248-zueoyesj	608	49	)	)	-RRB-
cord-000248-zueoyesj	609	1	,	,	,
cord-000248-zueoyesj	609	2	MST1	MST1	NNP
cord-000248-zueoyesj	609	3	/	/	SYM
cord-000248-zueoyesj	609	4	STK4	STK4	NNP
cord-000248-zueoyesj	609	5	(	(	-LRB-
cord-000248-zueoyesj	609	6	along	along	IN
cord-000248-zueoyesj	609	7	with	with	IN
cord-000248-zueoyesj	609	8	MST2	MST2	NNP
cord-000248-zueoyesj	609	9	/	/	SYM
cord-000248-zueoyesj	609	10	STK3	STK3	NNP
cord-000248-zueoyesj	609	11	)	)	-RRB-
cord-000248-zueoyesj	609	12	act	act	VBP
cord-000248-zueoyesj	609	13	as	as	IN
cord-000248-zueoyesj	609	14	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	609	15	of	of	IN
cord-000248-zueoyesj	609	16	endogenous	endogenous	JJ
cord-000248-zueoyesj	609	17	AKT1	AKT1	NNP
cord-000248-zueoyesj	609	18	,	,	,
cord-000248-zueoyesj	609	19	a	a	DT
cord-000248-zueoyesj	609	20	mediator	mediator	NN
cord-000248-zueoyesj	609	21	of	of	IN
cord-000248-zueoyesj	609	22	cell	cell	NN
cord-000248-zueoyesj	609	23	growth	growth	NN
cord-000248-zueoyesj	609	24	and	and	CC
cord-000248-zueoyesj	609	25	survival	survival	NN
cord-000248-zueoyesj	609	26	[	[	-LRB-
cord-000248-zueoyesj	609	27	545	545	CD
cord-000248-zueoyesj	609	28	]	]	-RRB-
cord-000248-zueoyesj	609	29	.	.	.
cord-000248-zueoyesj	610	1	We	-PRON-	PRP
cord-000248-zueoyesj	610	2	can	can	MD
cord-000248-zueoyesj	610	3	not	not	RB
cord-000248-zueoyesj	610	4	yet	yet	RB
cord-000248-zueoyesj	610	5	know	know	VB
cord-000248-zueoyesj	610	6	what	what	WP
cord-000248-zueoyesj	610	7	reason	reason	NN
cord-000248-zueoyesj	610	8	is	be	VBZ
cord-000248-zueoyesj	610	9	behind	behind	IN
cord-000248-zueoyesj	610	10	their	-PRON-	PRP$
cord-000248-zueoyesj	610	11	joint	joint	JJ
cord-000248-zueoyesj	610	12	downregulation	downregulation	NN
cord-000248-zueoyesj	610	13	,	,	,
cord-000248-zueoyesj	610	14	but	but	CC
cord-000248-zueoyesj	610	15	another	another	DT
cord-000248-zueoyesj	610	16	interesting	interesting	JJ
cord-000248-zueoyesj	610	17	common	common	JJ
cord-000248-zueoyesj	610	18	denominator	denominator	NN
cord-000248-zueoyesj	610	19	is	be	VBZ
cord-000248-zueoyesj	610	20	that	that	IN
cord-000248-zueoyesj	610	21	12	12	CD
cord-000248-zueoyesj	610	22	out	out	IN
cord-000248-zueoyesj	610	23	of	of	IN
cord-000248-zueoyesj	610	24	13	13	CD
cord-000248-zueoyesj	610	25	genes	gene	NNS
cord-000248-zueoyesj	610	26	share	share	VBP
cord-000248-zueoyesj	610	27	a	a	DT
cord-000248-zueoyesj	610	28	regulatory	regulatory	JJ
cord-000248-zueoyesj	610	29	motif	motif	NN
cord-000248-zueoyesj	610	30	for	for	IN
cord-000248-zueoyesj	610	31	NF	NF	NNP
cord-000248-zueoyesj	610	32	-	-	HYPH
cord-000248-zueoyesj	610	33	kappaB	kappaB	NNP
cord-000248-zueoyesj	610	34	(	(	-LRB-
cord-000248-zueoyesj	610	35	according	accord	VBG
cord-000248-zueoyesj	610	36	to	to	IN
cord-000248-zueoyesj	610	37	TRANSFAC	TRANSFAC	NNP
cord-000248-zueoyesj	610	38	,	,	,
cord-000248-zueoyesj	610	39	V$NFKB_Q6_01	V$NFKB_Q6_01	NNP
cord-000248-zueoyesj	610	40	)	)	-RRB-
cord-000248-zueoyesj	610	41	.	.	.
cord-000248-zueoyesj	611	1	A	a	DT
cord-000248-zueoyesj	611	2	putative	putative	JJ
cord-000248-zueoyesj	611	3	role	role	NN
cord-000248-zueoyesj	611	4	for	for	IN
cord-000248-zueoyesj	611	5	NF	NF	NNP
cord-000248-zueoyesj	611	6	-	-	HYPH
cord-000248-zueoyesj	611	7	kappaB	kappaB	NNP
cord-000248-zueoyesj	611	8	in	in	IN
cord-000248-zueoyesj	611	9	prostate	prostate	NN
cord-000248-zueoyesj	611	10	cancer	cancer	NN
cord-000248-zueoyesj	611	11	has	have	VBZ
cord-000248-zueoyesj	611	12	been	be	VBN
cord-000248-zueoyesj	611	13	reported	report	VBN
cord-000248-zueoyesj	611	14	based	base	VBN
cord-000248-zueoyesj	611	15	on	on	IN
cord-000248-zueoyesj	611	16	the	the	DT
cord-000248-zueoyesj	611	17	observation	observation	NN
cord-000248-zueoyesj	611	18	of	of	IN
cord-000248-zueoyesj	611	19	the	the	DT
cord-000248-zueoyesj	611	20	centrality	centrality	NN
cord-000248-zueoyesj	611	21	of	of	IN
cord-000248-zueoyesj	611	22	NFKB	NFKB	NNP
cord-000248-zueoyesj	611	23	on	on	IN
cord-000248-zueoyesj	611	24	two	two	CD
cord-000248-zueoyesj	611	25	up	up	RB
cord-000248-zueoyesj	611	26	-	-	:
cord-000248-zueoyesj	611	27	and	and	CC
cord-000248-zueoyesj	611	28	downregulated	downregulated	JJ
cord-000248-zueoyesj	611	29	networks	network	NNS
cord-000248-zueoyesj	611	30	compairing	compaire	VBG
cord-000248-zueoyesj	611	31	prostate	prostate	NN
cord-000248-zueoyesj	611	32	tumors	tumor	NNS
cord-000248-zueoyesj	611	33	and	and	CC
cord-000248-zueoyesj	611	34	healthy	healthy	JJ
cord-000248-zueoyesj	611	35	tissue	tissue	NN
cord-000248-zueoyesj	611	36	[	[	-LRB-
cord-000248-zueoyesj	611	37	546	546	CD
cord-000248-zueoyesj	611	38	]	]	-RRB-
cord-000248-zueoyesj	611	39	and	and	CC
cord-000248-zueoyesj	611	40	in	in	IN
cord-000248-zueoyesj	611	41	a	a	DT
cord-000248-zueoyesj	611	42	larger	large	JJR
cord-000248-zueoyesj	611	43	study	study	NN
cord-000248-zueoyesj	611	44	by	by	IN
cord-000248-zueoyesj	611	45	McDonnel	McDonnel	NNP
cord-000248-zueoyesj	611	46	et	et	NNP
cord-000248-zueoyesj	611	47	al	al	NNP
cord-000248-zueoyesj	611	48	.	.	.
cord-000248-zueoyesj	612	1	[	[	-LRB-
cord-000248-zueoyesj	612	2	547	547	CD
cord-000248-zueoyesj	612	3	]	]	-RRB-
cord-000248-zueoyesj	612	4	(	(	-LRB-
cord-000248-zueoyesj	612	5	255	255	CD
cord-000248-zueoyesj	612	6	core	core	NN
cord-000248-zueoyesj	612	7	prostate	prostate	NN
cord-000248-zueoyesj	612	8	cancer	cancer	NN
cord-000248-zueoyesj	612	9	tissue	tissue	NN
cord-000248-zueoyesj	612	10	microarrays	microarray	NNS
cord-000248-zueoyesj	612	11	from	from	IN
cord-000248-zueoyesj	612	12	47	47	CD
cord-000248-zueoyesj	612	13	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	612	14	specimens	specimen	NNS
cord-000248-zueoyesj	612	15	)	)	-RRB-
cord-000248-zueoyesj	612	16	.	.	.
cord-000248-zueoyesj	613	1	Several	several	JJ
cord-000248-zueoyesj	613	2	other	other	JJ
cord-000248-zueoyesj	613	3	researchers	researcher	NNS
cord-000248-zueoyesj	613	4	are	be	VBP
cord-000248-zueoyesj	613	5	currently	currently	RB
cord-000248-zueoyesj	613	6	investigating	investigate	VBG
cord-000248-zueoyesj	613	7	different	different	JJ
cord-000248-zueoyesj	613	8	roles	role	NNS
cord-000248-zueoyesj	613	9	of	of	IN
cord-000248-zueoyesj	613	10	the	the	DT
cord-000248-zueoyesj	613	11	NFKB	NFKB	NNP
cord-000248-zueoyesj	613	12	family	family	NN
cord-000248-zueoyesj	613	13	in	in	IN
cord-000248-zueoyesj	613	14	prostate	prostate	NN
cord-000248-zueoyesj	613	15	cancer	cancer	NN
cord-000248-zueoyesj	613	16	[	[	-LRB-
cord-000248-zueoyesj	613	17	548	548	CD
cord-000248-zueoyesj	613	18	,	,	,
cord-000248-zueoyesj	613	19	549	549	CD
cord-000248-zueoyesj	613	20	,	,	,
cord-000248-zueoyesj	613	21	550	550	CD
cord-000248-zueoyesj	613	22	,	,	,
cord-000248-zueoyesj	613	23	551	551	CD
cord-000248-zueoyesj	613	24	,	,	,
cord-000248-zueoyesj	613	25	552	552	CD
cord-000248-zueoyesj	613	26	,	,	,
cord-000248-zueoyesj	613	27	553	553	CD
cord-000248-zueoyesj	613	28	,	,	,
cord-000248-zueoyesj	613	29	554	554	CD
cord-000248-zueoyesj	613	30	,	,	,
cord-000248-zueoyesj	613	31	555	555	CD
cord-000248-zueoyesj	613	32	]	]	-RRB-
cord-000248-zueoyesj	613	33	and	and	CC
cord-000248-zueoyesj	613	34	it	-PRON-	PRP
cord-000248-zueoyesj	613	35	could	could	MD
cord-000248-zueoyesj	613	36	be	be	VB
cord-000248-zueoyesj	613	37	a	a	DT
cord-000248-zueoyesj	613	38	promising	promising	JJ
cord-000248-zueoyesj	613	39	target	target	NN
cord-000248-zueoyesj	613	40	for	for	IN
cord-000248-zueoyesj	613	41	intervention	intervention	NN
cord-000248-zueoyesj	613	42	[	[	-LRB-
cord-000248-zueoyesj	613	43	555	555	CD
cord-000248-zueoyesj	613	44	,	,	,
cord-000248-zueoyesj	613	45	556	556	CD
cord-000248-zueoyesj	613	46	,	,	,
cord-000248-zueoyesj	613	47	557	557	CD
cord-000248-zueoyesj	613	48	,	,	,
cord-000248-zueoyesj	613	49	558	558	CD
cord-000248-zueoyesj	613	50	,	,	,
cord-000248-zueoyesj	613	51	559	559	CD
cord-000248-zueoyesj	613	52	,	,	,
cord-000248-zueoyesj	613	53	560	560	CD
cord-000248-zueoyesj	613	54	,	,	,
cord-000248-zueoyesj	613	55	561	561	CD
cord-000248-zueoyesj	613	56	,	,	,
cord-000248-zueoyesj	613	57	562	562	CD
cord-000248-zueoyesj	613	58	,	,	,
cord-000248-zueoyesj	613	59	563	563	CD
cord-000248-zueoyesj	613	60	,	,	,
cord-000248-zueoyesj	613	61	564	564	CD
cord-000248-zueoyesj	613	62	,	,	,
cord-000248-zueoyesj	613	63	565	565	CD
cord-000248-zueoyesj	613	64	,	,	,
cord-000248-zueoyesj	613	65	566	566	CD
cord-000248-zueoyesj	613	66	,	,	,
cord-000248-zueoyesj	613	67	567	567	CD
cord-000248-zueoyesj	613	68	,	,	,
cord-000248-zueoyesj	613	69	568	568	CD
cord-000248-zueoyesj	613	70	,	,	,
cord-000248-zueoyesj	613	71	569	569	CD
cord-000248-zueoyesj	613	72	,	,	,
cord-000248-zueoyesj	613	73	570	570	CD
cord-000248-zueoyesj	613	74	,	,	,
cord-000248-zueoyesj	613	75	571	571	CD
cord-000248-zueoyesj	613	76	]	]	-RRB-
cord-000248-zueoyesj	613	77	.	.	.
cord-000248-zueoyesj	614	1	If	if	IN
cord-000248-zueoyesj	614	2	we	-PRON-	PRP
cord-000248-zueoyesj	614	3	include	include	VBP
cord-000248-zueoyesj	614	4	other	other	JJ
cord-000248-zueoyesj	614	5	genes	gene	NNS
cord-000248-zueoyesj	614	6	following	follow	VBG
cord-000248-zueoyesj	614	7	the	the	DT
cord-000248-zueoyesj	614	8	ranking	ranking	JJ
cord-000248-zueoyesj	614	9	order	order	NN
cord-000248-zueoyesj	614	10	,	,	,
cord-000248-zueoyesj	614	11	the	the	DT
cord-000248-zueoyesj	614	12	first	first	JJ
cord-000248-zueoyesj	614	13	38	38	CD
cord-000248-zueoyesj	614	14	genes	gene	NNS
cord-000248-zueoyesj	614	15	in	in	IN
cord-000248-zueoyesj	614	16	the	the	DT
cord-000248-zueoyesj	614	17	ranking	ranking	NN
cord-000248-zueoyesj	614	18	include	include	VBP
cord-000248-zueoyesj	614	19	33	33	CD
cord-000248-zueoyesj	614	20	that	that	WDT
cord-000248-zueoyesj	614	21	have	have	VBP
cord-000248-zueoyesj	614	22	the	the	DT
cord-000248-zueoyesj	614	23	regulatory	regulatory	JJ
cord-000248-zueoyesj	614	24	motif	motif	NN
cord-000248-zueoyesj	614	25	V$NFKB_Q6_01	V$NFKB_Q6_01	NNP
cord-000248-zueoyesj	615	1	(	(	-LRB-
cord-000248-zueoyesj	615	2	GATHER	gather	VB
cord-000248-zueoyesj	615	3	reports	report	NNS
cord-000248-zueoyesj	615	4	for	for	IN
cord-000248-zueoyesj	615	5	this	this	DT
cord-000248-zueoyesj	615	6	list	list	NN
cord-000248-zueoyesj	615	7	a	a	DT
cord-000248-zueoyesj	615	8	p	p	NN
cord-000248-zueoyesj	615	9	-	-	HYPH
cord-000248-zueoyesj	615	10	value	value	NN
cord-000248-zueoyesj	615	11	of	of	IN
cord-000248-zueoyesj	615	12	0.0006	0.0006	CD
cord-000248-zueoyesj	615	13	)	)	-RRB-
cord-000248-zueoyesj	615	14	.	.	.
cord-000248-zueoyesj	616	1	Even	even	RB
cord-000248-zueoyesj	616	2	when	when	WRB
cord-000248-zueoyesj	616	3	we	-PRON-	PRP
cord-000248-zueoyesj	616	4	double	double	VBP
cord-000248-zueoyesj	616	5	the	the	DT
cord-000248-zueoyesj	616	6	list	list	NN
cord-000248-zueoyesj	616	7	to	to	IN
cord-000248-zueoyesj	616	8	the	the	DT
cord-000248-zueoyesj	616	9	probes	probe	NNS
cord-000248-zueoyesj	616	10	that	that	WDT
cord-000248-zueoyesj	616	11	correspond	correspond	VBP
cord-000248-zueoyesj	616	12	to	to	IN
cord-000248-zueoyesj	616	13	the	the	DT
cord-000248-zueoyesj	616	14	first	first	JJ
cord-000248-zueoyesj	616	15	76	76	CD
cord-000248-zueoyesj	616	16	different	different	JJ
cord-000248-zueoyesj	616	17	genes	gene	NNS
cord-000248-zueoyesj	616	18	recognized	recognize	VBN
cord-000248-zueoyesj	616	19	by	by	IN
cord-000248-zueoyesj	616	20	GATHER	gather	NN
cord-000248-zueoyesj	616	21	,	,	,
cord-000248-zueoyesj	616	22	58	58	CD
cord-000248-zueoyesj	616	23	of	of	IN
cord-000248-zueoyesj	616	24	them	-PRON-	PRP
cord-000248-zueoyesj	616	25	have	have	VBP
cord-000248-zueoyesj	616	26	the	the	DT
cord-000248-zueoyesj	616	27	regulatory	regulatory	JJ
cord-000248-zueoyesj	616	28	motif	motif	NN
cord-000248-zueoyesj	617	1	V$NFKB_Q6_01	V$NFKB_Q6_01	NNP
cord-000248-zueoyesj	617	2	,	,	,
cord-000248-zueoyesj	617	3	with	with	IN
cord-000248-zueoyesj	617	4	p	p	NN
cord-000248-zueoyesj	617	5	-	-	HYPH
cord-000248-zueoyesj	617	6	value	value	NN
cord-000248-zueoyesj	617	7	=	=	SYM
cord-000248-zueoyesj	617	8	0.003	0.003	CD
cord-000248-zueoyesj	618	1	(	(	-LRB-
cord-000248-zueoyesj	618	2	ATP6AP2	atp6ap2	UH
cord-000248-zueoyesj	618	3	,	,	,
cord-000248-zueoyesj	618	4	BCAT1	BCAT1	NNP
cord-000248-zueoyesj	618	5	,	,	,
cord-000248-zueoyesj	618	6	BTG2	BTG2	NNP
cord-000248-zueoyesj	618	7	[	[	-LRB-
cord-000248-zueoyesj	618	8	572	572	CD
cord-000248-zueoyesj	618	9	,	,	,
cord-000248-zueoyesj	618	10	573	573	CD
cord-000248-zueoyesj	618	11	,	,	,
cord-000248-zueoyesj	618	12	574	574	CD
cord-000248-zueoyesj	618	13	,	,	,
cord-000248-zueoyesj	618	14	575	575	CD
cord-000248-zueoyesj	618	15	,	,	,
cord-000248-zueoyesj	618	16	576	576	CD
cord-000248-zueoyesj	618	17	,	,	,
cord-000248-zueoyesj	618	18	577	577	CD
cord-000248-zueoyesj	618	19	,	,	,
cord-000248-zueoyesj	618	20	578	578	CD
cord-000248-zueoyesj	618	21	]	]	-RRB-
cord-000248-zueoyesj	618	22	,	,	.
cord-000248-zueoyesj	619	1	C14orf123	C14orf123	NNPS
cord-000248-zueoyesj	619	2	,	,	,
cord-000248-zueoyesj	619	3	C18orf45	C18orf45	NNP
cord-000248-zueoyesj	619	4	,	,	,
cord-000248-zueoyesj	619	5	CCL2	CCL2	NNP
cord-000248-zueoyesj	619	6	,	,	,
cord-000248-zueoyesj	619	7	CD302	CD302	NNP
cord-000248-zueoyesj	619	8	,	,	,
cord-000248-zueoyesj	619	9	CD40	CD40	NNP
cord-000248-zueoyesj	619	10	(	(	-LRB-
cord-000248-zueoyesj	619	11	already	already	RB
cord-000248-zueoyesj	619	12	discussed	discuss	VBN
cord-000248-zueoyesj	619	13	)	)	-RRB-
cord-000248-zueoyesj	619	14	,	,	,
cord-000248-zueoyesj	619	15	CD59	CD59	NNP
cord-000248-zueoyesj	619	16	(	(	-LRB-
cord-000248-zueoyesj	619	17	already	already	RB
cord-000248-zueoyesj	619	18	discussed	discuss	VBN
cord-000248-zueoyesj	619	19	)	)	-RRB-
cord-000248-zueoyesj	619	20	,	,	,
cord-000248-zueoyesj	619	21	CHI3L1	CHI3L1	NNP
cord-000248-zueoyesj	619	22	,	,	,
cord-000248-zueoyesj	619	23	COL16A1	COL16A1	NNP
cord-000248-zueoyesj	619	24	,	,	,
cord-000248-zueoyesj	619	25	COMMD6	COMMD6	NNP
cord-000248-zueoyesj	619	26	,	,	,
cord-000248-zueoyesj	619	27	CRABP2	CRABP2	NNP
cord-000248-zueoyesj	619	28	,	,	,
cord-000248-zueoyesj	619	29	CSRP1	CSRP1	NNP
cord-000248-zueoyesj	619	30	,	,	,
cord-000248-zueoyesj	619	31	CTBP2	CTBP2	NNP
cord-000248-zueoyesj	619	32	,	,	,
cord-000248-zueoyesj	619	33	CTGF	CTGF	NNP
cord-000248-zueoyesj	619	34	(	(	-LRB-
cord-000248-zueoyesj	619	35	Connective	connective	JJ
cord-000248-zueoyesj	619	36	tissue	tissue	NN
cord-000248-zueoyesj	619	37	growth	growth	NN
cord-000248-zueoyesj	619	38	factor	factor	NN
cord-000248-zueoyesj	619	39	,	,	,
cord-000248-zueoyesj	619	40	[	[	-LRB-
cord-000248-zueoyesj	619	41	579	579	CD
cord-000248-zueoyesj	619	42	,	,	,
cord-000248-zueoyesj	619	43	580	580	CD
cord-000248-zueoyesj	619	44	,	,	,
cord-000248-zueoyesj	619	45	581	581	CD
cord-000248-zueoyesj	619	46	,	,	,
cord-000248-zueoyesj	619	47	582	582	CD
cord-000248-zueoyesj	619	48	]	]	-RRB-
cord-000248-zueoyesj	619	49	)	)	-RRB-
cord-000248-zueoyesj	620	1	,	,	,
cord-000248-zueoyesj	620	2	DES	DES	NNP
cord-000248-zueoyesj	620	3	,	,	,
cord-000248-zueoyesj	620	4	DMN	DMN	NNP
cord-000248-zueoyesj	620	5	,	,	,
cord-000248-zueoyesj	620	6	DNAJB1	dnajb1	NN
cord-000248-zueoyesj	620	7	,	,	,
cord-000248-zueoyesj	620	8	EGF	EGF	NNP
cord-000248-zueoyesj	620	9	,	,	,
cord-000248-zueoyesj	620	10	EMP1	EMP1	NNP
cord-000248-zueoyesj	620	11	,	,	,
cord-000248-zueoyesj	620	12	FHL2	FHL2	NNP
cord-000248-zueoyesj	620	13	[	[	-LRB-
cord-000248-zueoyesj	620	14	583	583	CD
cord-000248-zueoyesj	620	15	,	,	,
cord-000248-zueoyesj	620	16	584	584	CD
cord-000248-zueoyesj	620	17	,	,	,
cord-000248-zueoyesj	620	18	585	585	CD
cord-000248-zueoyesj	620	19	,	,	,
cord-000248-zueoyesj	620	20	586	586	CD
cord-000248-zueoyesj	620	21	,	,	,
cord-000248-zueoyesj	620	22	587	587	CD
cord-000248-zueoyesj	620	23	,	,	,
cord-000248-zueoyesj	620	24	588	588	CD
cord-000248-zueoyesj	620	25	]	]	-RRB-
cord-000248-zueoyesj	620	26	,	,	,
cord-000248-zueoyesj	620	27	GRIPAP1	gripap1	RB
cord-000248-zueoyesj	620	28	,	,	,
cord-000248-zueoyesj	620	29	GSTM1	GSTM1	NNP
cord-000248-zueoyesj	620	30	[	[	-LRB-
cord-000248-zueoyesj	620	31	589	589	CD
cord-000248-zueoyesj	620	32	,	,	,
cord-000248-zueoyesj	620	33	590	590	CD
cord-000248-zueoyesj	620	34	]	]	-RRB-
cord-000248-zueoyesj	620	35	,	,	,
cord-000248-zueoyesj	620	36	HBEGF	HBEGF	NNP
cord-000248-zueoyesj	620	37	,	,	,
cord-000248-zueoyesj	620	38	IL4R	IL4R	NNP
cord-000248-zueoyesj	620	39	,	,	,
cord-000248-zueoyesj	620	40	ITGA3	ITGA3	''
cord-000248-zueoyesj	620	41	,	,	,
cord-000248-zueoyesj	620	42	ITGA7	itga7	CD
cord-000248-zueoyesj	620	43	,	,	,
cord-000248-zueoyesj	620	44	JUNB	JUNB	NNP
cord-000248-zueoyesj	620	45	[	[	-LRB-
cord-000248-zueoyesj	620	46	591	591	CD
cord-000248-zueoyesj	620	47	,	,	,
cord-000248-zueoyesj	620	48	592	592	CD
cord-000248-zueoyesj	620	49	]	]	-RRB-
cord-000248-zueoyesj	620	50	,	,	,
cord-000248-zueoyesj	620	51	KIAA0152	KIAA0152	NNP
cord-000248-zueoyesj	620	52	,	,	,
cord-000248-zueoyesj	620	53	KIAA1191	KIAA1191	NNP
cord-000248-zueoyesj	620	54	,	,	,
cord-000248-zueoyesj	620	55	KIAA1324	KIAA1324	NNP
cord-000248-zueoyesj	620	56	,	,	,
cord-000248-zueoyesj	620	57	KLF6	KLF6	NNP
cord-000248-zueoyesj	620	58	,	,	,
cord-000248-zueoyesj	620	59	LAMB2	LAMB2	NNP
cord-000248-zueoyesj	620	60	,	,	,
cord-000248-zueoyesj	620	61	LMNA	LMNA	NNP
cord-000248-zueoyesj	620	62	(	(	-LRB-
cord-000248-zueoyesj	620	63	already	already	RB
cord-000248-zueoyesj	620	64	discussed	discuss	VBN
cord-000248-zueoyesj	620	65	)	)	-RRB-
cord-000248-zueoyesj	620	66	,	,	,
cord-000248-zueoyesj	620	67	NFATC1	nfatc1	UH
cord-000248-zueoyesj	620	68	,	,	,
cord-000248-zueoyesj	620	69	NFKB2	NFKB2	NNP
cord-000248-zueoyesj	620	70	,	,	,
cord-000248-zueoyesj	620	71	NUDC	NUDC	NNP
cord-000248-zueoyesj	620	72	[	[	-LRB-
cord-000248-zueoyesj	620	73	593	593	CD
cord-000248-zueoyesj	620	74	]	]	-RRB-
cord-000248-zueoyesj	620	75	,	,	,
cord-000248-zueoyesj	620	76	P4HB	P4HB	NNP
cord-000248-zueoyesj	620	77	,	,	,
cord-000248-zueoyesj	620	78	PDK2	PDK2	NNP
cord-000248-zueoyesj	620	79	,	,	,
cord-000248-zueoyesj	620	80	PIM1	PIM1	NNP
cord-000248-zueoyesj	620	81	,	,	,
cord-000248-zueoyesj	620	82	PISD	PISD	NNP
cord-000248-zueoyesj	620	83	,	,	,
cord-000248-zueoyesj	620	84	PXN	PXN	NNP
cord-000248-zueoyesj	620	85	,	,	,
cord-000248-zueoyesj	620	86	RAP1B	rap1b	NN
cord-000248-zueoyesj	620	87	,	,	,
cord-000248-zueoyesj	620	88	RNF40	RNF40	NNP
cord-000248-zueoyesj	620	89	,	,	,
cord-000248-zueoyesj	620	90	SARA1	SARA1	NNP
cord-000248-zueoyesj	620	91	,	,	,
cord-000248-zueoyesj	620	92	SEC61A1	sec61a1	NN
cord-000248-zueoyesj	620	93	,	,	,
cord-000248-zueoyesj	620	94	SGTA	SGTA	NNP
cord-000248-zueoyesj	620	95	[	[	-LRB-
cord-000248-zueoyesj	620	96	594	594	CD
cord-000248-zueoyesj	620	97	]	]	-RRB-
cord-000248-zueoyesj	620	98	,	,	,
cord-000248-zueoyesj	620	99	SLC12A2	SLC12A2	NNP
cord-000248-zueoyesj	620	100	,	,	,
cord-000248-zueoyesj	620	101	SRD5A2	SRD5A2	NNP
cord-000248-zueoyesj	620	102	,	,	,
cord-000248-zueoyesj	621	1	STAT6	STAT6	NNS
cord-000248-zueoyesj	622	1	[	[	-LRB-
cord-000248-zueoyesj	622	2	595	595	CD
cord-000248-zueoyesj	622	3	,	,	,
cord-000248-zueoyesj	622	4	596	596	CD
cord-000248-zueoyesj	622	5	]	]	-RRB-
cord-000248-zueoyesj	622	6	,	,	,
cord-000248-zueoyesj	622	7	TACSTD2	TACSTD2	NNP
cord-000248-zueoyesj	622	8	,	,	,
cord-000248-zueoyesj	622	9	TBX1	TBX1	NNP
cord-000248-zueoyesj	622	10	,	,	,
cord-000248-zueoyesj	622	11	TMED3	TMED3	NNP
cord-000248-zueoyesj	622	12	,	,	,
cord-000248-zueoyesj	622	13	VPS39	vps39	NN
cord-000248-zueoyesj	622	14	,	,	,
cord-000248-zueoyesj	622	15	WDFY3	WDFY3	NNP
cord-000248-zueoyesj	622	16	,	,	,
cord-000248-zueoyesj	622	17	XBP1	XBP1	NNP
cord-000248-zueoyesj	623	1	[	[	-LRB-
cord-000248-zueoyesj	623	2	544	544	CD
cord-000248-zueoyesj	623	3	]	]	-RRB-
cord-000248-zueoyesj	623	4	,	,	,
cord-000248-zueoyesj	623	5	ZAK	ZAK	NNP
cord-000248-zueoyesj	623	6	)	)	-RRB-
cord-000248-zueoyesj	623	7	.	.	.
cord-000248-zueoyesj	624	1	This	this	DT
cord-000248-zueoyesj	624	2	result	result	NN
cord-000248-zueoyesj	624	3	indicates	indicate	VBZ
cord-000248-zueoyesj	624	4	that	that	IN
cord-000248-zueoyesj	624	5	our	-PRON-	PRP$
cord-000248-zueoyesj	624	6	results	result	NNS
cord-000248-zueoyesj	624	7	support	support	VBP
cord-000248-zueoyesj	624	8	the	the	DT
cord-000248-zueoyesj	624	9	importance	importance	NN
cord-000248-zueoyesj	624	10	of	of	IN
cord-000248-zueoyesj	624	11	NFkappa	NFkappa	NNP
cord-000248-zueoyesj	624	12	-	-	HYPH
cord-000248-zueoyesj	624	13	B	B	NNP
cord-000248-zueoyesj	624	14	and	and	CC
cord-000248-zueoyesj	624	15	the	the	DT
cord-000248-zueoyesj	624	16	huge	huge	JJ
cord-000248-zueoyesj	624	17	amount	amount	NN
cord-000248-zueoyesj	624	18	of	of	IN
cord-000248-zueoyesj	624	19	research	research	NN
cord-000248-zueoyesj	624	20	effort	effort	NN
cord-000248-zueoyesj	624	21	to	to	TO
cord-000248-zueoyesj	624	22	understand	understand	VB
cord-000248-zueoyesj	624	23	the	the	DT
cord-000248-zueoyesj	624	24	role	role	NN
cord-000248-zueoyesj	624	25	of	of	IN
cord-000248-zueoyesj	624	26	the	the	DT
cord-000248-zueoyesj	624	27	NFkappa	NFkappa	NNP
cord-000248-zueoyesj	624	28	-	-	HYPH
cord-000248-zueoyesj	624	29	B	B	NNP
cord-000248-zueoyesj	624	30	activity	activity	NN
cord-000248-zueoyesj	624	31	and	and	CC
cord-000248-zueoyesj	624	32	its	-PRON-	PRP$
cord-000248-zueoyesj	624	33	potential	potential	NN
cord-000248-zueoyesj	624	34	as	as	IN
cord-000248-zueoyesj	624	35	a	a	DT
cord-000248-zueoyesj	624	36	target	target	NN
cord-000248-zueoyesj	624	37	for	for	IN
cord-000248-zueoyesj	624	38	intervention	intervention	NN
cord-000248-zueoyesj	624	39	in	in	IN
cord-000248-zueoyesj	624	40	prostate	prostate	NN
cord-000248-zueoyesj	624	41	cancer	cancer	NN
cord-000248-zueoyesj	624	42	(	(	-LRB-
cord-000248-zueoyesj	624	43	File	File	NNP
cord-000248-zueoyesj	624	44	S4	S4	NNP
cord-000248-zueoyesj	624	45	)	)	-RRB-
cord-000248-zueoyesj	624	46	.	.	.
cord-000248-zueoyesj	625	1	The	the	DT
cord-000248-zueoyesj	625	2	group	group	NN
cord-000248-zueoyesj	625	3	of	of	IN
cord-000248-zueoyesj	625	4	58	58	CD
cord-000248-zueoyesj	625	5	biomarkers	biomarker	NNS
cord-000248-zueoyesj	625	6	contains	contain	VBZ
cord-000248-zueoyesj	625	7	one	one	CD
cord-000248-zueoyesj	625	8	of	of	IN
cord-000248-zueoyesj	625	9	particular	particular	JJ
cord-000248-zueoyesj	625	10	interest	interest	NN
cord-000248-zueoyesj	625	11	,	,	,
cord-000248-zueoyesj	625	12	STAT6	stat6	XX
cord-000248-zueoyesj	625	13	.	.	.
cord-000248-zueoyesj	626	1	This	this	DT
cord-000248-zueoyesj	626	2	gene	gene	NN
cord-000248-zueoyesj	626	3	is	be	VBZ
cord-000248-zueoyesj	626	4	considered	consider	VBN
cord-000248-zueoyesj	626	5	a	a	DT
cord-000248-zueoyesj	626	6	survival	survival	NN
cord-000248-zueoyesj	626	7	factor	factor	NN
cord-000248-zueoyesj	626	8	in	in	IN
cord-000248-zueoyesj	626	9	prostate	prostate	NN
cord-000248-zueoyesj	626	10	cancer	cancer	NN
cord-000248-zueoyesj	626	11	and	and	CC
cord-000248-zueoyesj	626	12	a	a	DT
cord-000248-zueoyesj	626	13	key	key	JJ
cord-000248-zueoyesj	626	14	regulator	regulator	NN
cord-000248-zueoyesj	626	15	of	of	IN
cord-000248-zueoyesj	626	16	the	the	DT
cord-000248-zueoyesj	626	17	genetic	genetic	JJ
cord-000248-zueoyesj	626	18	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	626	19	program	program	NN
cord-000248-zueoyesj	626	20	responsible	responsible	JJ
cord-000248-zueoyesj	626	21	for	for	IN
cord-000248-zueoyesj	626	22	progression	progression	NN
cord-000248-zueoyesj	626	23	[	[	-LRB-
cord-000248-zueoyesj	626	24	595	595	CD
cord-000248-zueoyesj	626	25	]	]	-RRB-
cord-000248-zueoyesj	626	26	.	.	.
cord-000248-zueoyesj	627	1	STAT6	STAT6	NNP
cord-000248-zueoyesj	627	2	has	have	VBZ
cord-000248-zueoyesj	627	3	been	be	VBN
cord-000248-zueoyesj	627	4	recently	recently	RB
cord-000248-zueoyesj	627	5	linked	link	VBN
cord-000248-zueoyesj	627	6	to	to	IN
cord-000248-zueoyesj	627	7	HPN	HPN	NNP
cord-000248-zueoyesj	627	8	as	as	IN
cord-000248-zueoyesj	627	9	one	one	CD
cord-000248-zueoyesj	627	10	of	of	IN
cord-000248-zueoyesj	627	11	the	the	DT
cord-000248-zueoyesj	627	12	most	most	RBS
cord-000248-zueoyesj	627	13	robust	robust	JJ
cord-000248-zueoyesj	627	14	pair	pair	NN
cord-000248-zueoyesj	627	15	of	of	IN
cord-000248-zueoyesj	627	16	biomarkers	biomarker	NNS
cord-000248-zueoyesj	627	17	for	for	IN
cord-000248-zueoyesj	627	18	prostate	prostate	NN
cord-000248-zueoyesj	627	19	cancer	cancer	NN
cord-000248-zueoyesj	627	20	using	use	VBG
cord-000248-zueoyesj	627	21	an	an	DT
cord-000248-zueoyesj	627	22	integrative	integrative	JJ
cord-000248-zueoyesj	627	23	approach	approach	NN
cord-000248-zueoyesj	627	24	that	that	WDT
cord-000248-zueoyesj	627	25	linked	link	VBD
cord-000248-zueoyesj	627	26	several	several	JJ
cord-000248-zueoyesj	627	27	microarray	microarray	NN
cord-000248-zueoyesj	627	28	datasets	dataset	NNS
cord-000248-zueoyesj	627	29	[	[	-LRB-
cord-000248-zueoyesj	627	30	596	596	CD
cord-000248-zueoyesj	627	31	]	]	-RRB-
cord-000248-zueoyesj	627	32	.	.	.
cord-000248-zueoyesj	628	1	Analysis	analysis	NN
cord-000248-zueoyesj	628	2	using	use	VBG
cord-000248-zueoyesj	628	3	GATHER	gather	NN
cord-000248-zueoyesj	628	4	of	of	IN
cord-000248-zueoyesj	628	5	this	this	DT
cord-000248-zueoyesj	628	6	group	group	NN
cord-000248-zueoyesj	628	7	reveals	reveal	VBZ
cord-000248-zueoyesj	628	8	that	that	IN
cord-000248-zueoyesj	628	9	six	six	CD
cord-000248-zueoyesj	628	10	of	of	IN
cord-000248-zueoyesj	628	11	these	these	DT
cord-000248-zueoyesj	628	12	58	58	CD
cord-000248-zueoyesj	628	13	genes	gene	NNS
cord-000248-zueoyesj	628	14	are	be	VBP
cord-000248-zueoyesj	628	15	in	in	IN
cord-000248-zueoyesj	628	16	KEGG	KEGG	NNP
cord-000248-zueoyesj	628	17	pathway	pathway	NN
cord-000248-zueoyesj	628	18	path	path	NN
cord-000248-zueoyesj	628	19	:	:	:
cord-000248-zueoyesj	629	1	hsa04510	hsa04510	NNP
cord-000248-zueoyesj	629	2	,	,	,
cord-000248-zueoyesj	629	3	Focal	focal	JJ
cord-000248-zueoyesj	629	4	adhesion	adhesion	NN
cord-000248-zueoyesj	629	5	(	(	-LRB-
cord-000248-zueoyesj	629	6	EGF	EGF	NNP
cord-000248-zueoyesj	629	7	,	,	,
cord-000248-zueoyesj	629	8	ITGA3	ITGA3	''
cord-000248-zueoyesj	629	9	,	,	,
cord-000248-zueoyesj	629	10	ITGA7	itga7	FW
cord-000248-zueoyesj	629	11	,	,	,
cord-000248-zueoyesj	630	1	LAMB2	LAMB2	NNP
cord-000248-zueoyesj	630	2	,	,	,
cord-000248-zueoyesj	630	3	PXN	PXN	NNP
cord-000248-zueoyesj	630	4	,	,	,
cord-000248-zueoyesj	630	5	RAP1B	rap1b	NN
cord-000248-zueoyesj	630	6	,	,	,
cord-000248-zueoyesj	630	7	p	p	NN
cord-000248-zueoyesj	630	8	-	-	HYPH
cord-000248-zueoyesj	630	9	value,0.0007	value,0.0007	NNP
cord-000248-zueoyesj	630	10	)	)	-RRB-
cord-000248-zueoyesj	631	1	and	and	CC
cord-000248-zueoyesj	631	2	from	from	IN
cord-000248-zueoyesj	631	3	these	these	DT
cord-000248-zueoyesj	631	4	there	there	EX
cord-000248-zueoyesj	631	5	are	be	VBP
cord-000248-zueoyesj	631	6	three	three	CD
cord-000248-zueoyesj	631	7	in	in	IN
cord-000248-zueoyesj	631	8	pathway	pathway	NN
cord-000248-zueoyesj	631	9	:	:	:
cord-000248-zueoyesj	632	1	hsa045122	hsa045122	NNP
cord-000248-zueoyesj	632	2	,	,	,
cord-000248-zueoyesj	632	3	ECM	ECM	NNP
cord-000248-zueoyesj	632	4	-	-	HYPH
cord-000248-zueoyesj	632	5	receptor	receptor	NN
cord-000248-zueoyesj	632	6	interaction	interaction	NN
cord-000248-zueoyesj	632	7	(	(	-LRB-
cord-000248-zueoyesj	632	8	ITGA3	ITGA3	''
cord-000248-zueoyesj	632	9	,	,	,
cord-000248-zueoyesj	632	10	ITGA7	itga7	CD
cord-000248-zueoyesj	632	11	,	,	,
cord-000248-zueoyesj	632	12	LAMB2	LAMB2	NNP
cord-000248-zueoyesj	632	13	,	,	,
cord-000248-zueoyesj	632	14	p	p	NN
cord-000248-zueoyesj	632	15	-	-	HYPH
cord-000248-zueoyesj	632	16	value,0.005	value,0.005	NNP
cord-000248-zueoyesj	632	17	)	)	-RRB-
cord-000248-zueoyesj	632	18	while	while	IN
cord-000248-zueoyesj	632	19	four	four	CD
cord-000248-zueoyesj	632	20	of	of	IN
cord-000248-zueoyesj	632	21	these	these	DT
cord-000248-zueoyesj	632	22	six	six	CD
cord-000248-zueoyesj	632	23	are	be	VBP
cord-000248-zueoyesj	632	24	also	also	RB
cord-000248-zueoyesj	632	25	in	in	IN
cord-000248-zueoyesj	632	26	path	path	NN
cord-000248-zueoyesj	632	27	:	:	:
cord-000248-zueoyesj	633	1	hsa04810	hsa04810	NNP
cord-000248-zueoyesj	633	2	:	:	:
cord-000248-zueoyesj	633	3	Regulation	regulation	NN
cord-000248-zueoyesj	633	4	of	of	IN
cord-000248-zueoyesj	633	5	actin	actin	NN
cord-000248-zueoyesj	633	6	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	633	7	,	,	,
cord-000248-zueoyesj	633	8	(	(	-LRB-
cord-000248-zueoyesj	633	9	EGF	EGF	NNP
cord-000248-zueoyesj	633	10	,	,	,
cord-000248-zueoyesj	633	11	ITGA3	ITGA3	''
cord-000248-zueoyesj	633	12	,	,	,
cord-000248-zueoyesj	633	13	ITGA7	itga7	CD
cord-000248-zueoyesj	633	14	,	,	,
cord-000248-zueoyesj	633	15	PXN	PXN	NNP
cord-000248-zueoyesj	633	16	,	,	,
cord-000248-zueoyesj	633	17	p	p	NN
cord-000248-zueoyesj	633	18	-	-	HYPH
cord-000248-zueoyesj	633	19	value,0.01	value,0.01	NN
cord-000248-zueoyesj	633	20	)	)	-RRB-
cord-000248-zueoyesj	633	21	.	.	.
cord-000248-zueoyesj	634	1	LAMB2	LAMB2	NNP
cord-000248-zueoyesj	634	2	.	.	.
cord-000248-zueoyesj	635	1	Alterations	alteration	NNS
cord-000248-zueoyesj	635	2	of	of	IN
cord-000248-zueoyesj	635	3	the	the	DT
cord-000248-zueoyesj	635	4	gene	gene	NN
cord-000248-zueoyesj	635	5	profile	profile	NN
cord-000248-zueoyesj	635	6	of	of	IN
cord-000248-zueoyesj	635	7	LAMB2	LAMB2	NNP
cord-000248-zueoyesj	635	8	and	and	CC
cord-000248-zueoyesj	635	9	CDKN2C	CDKN2C	NNP
cord-000248-zueoyesj	635	10	/	/	SYM
cord-000248-zueoyesj	635	11	p18(Ink4c	p18(ink4c	NN
cord-000248-zueoyesj	635	12	)	)	-RRB-
cord-000248-zueoyesj	635	13	,	,	,
cord-000248-zueoyesj	635	14	a	a	DT
cord-000248-zueoyesj	635	15	CDK4	CDK4	NNP
cord-000248-zueoyesj	635	16	inhibitor	inhibitor	NN
cord-000248-zueoyesj	635	17	,	,	,
cord-000248-zueoyesj	635	18	have	have	VBP
cord-000248-zueoyesj	635	19	been	be	VBN
cord-000248-zueoyesj	635	20	reported	report	VBN
cord-000248-zueoyesj	635	21	on	on	IN
cord-000248-zueoyesj	635	22	the	the	DT
cord-000248-zueoyesj	635	23	transition	transition	NN
cord-000248-zueoyesj	635	24	from	from	IN
cord-000248-zueoyesj	635	25	prostatic	prostatic	JJ
cord-000248-zueoyesj	635	26	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	635	27	neoplasia	neoplasia	NN
cord-000248-zueoyesj	635	28	(	(	-LRB-
cord-000248-zueoyesj	635	29	PIN	pin	NN
cord-000248-zueoyesj	635	30	)	)	-RRB-
cord-000248-zueoyesj	635	31	to	to	IN
cord-000248-zueoyesj	635	32	prostate	prostate	NN
cord-000248-zueoyesj	635	33	cancer	cancer	NN
cord-000248-zueoyesj	635	34	[	[	-LRB-
cord-000248-zueoyesj	635	35	597	597	CD
cord-000248-zueoyesj	635	36	]	]	-RRB-
cord-000248-zueoyesj	635	37	(	(	-LRB-
cord-000248-zueoyesj	635	38	see	see	VB
cord-000248-zueoyesj	635	39	also	also	RB
cord-000248-zueoyesj	635	40	[	[	-LRB-
cord-000248-zueoyesj	635	41	333	333	CD
cord-000248-zueoyesj	635	42	]	]	-RRB-
cord-000248-zueoyesj	635	43	)	)	-RRB-
cord-000248-zueoyesj	635	44	.	.	.
cord-000248-zueoyesj	636	1	3	3	LS
cord-000248-zueoyesj	636	2	)	)	-RRB-
cord-000248-zueoyesj	636	3	.	.	.
cord-000248-zueoyesj	637	1	The	the	DT
cord-000248-zueoyesj	637	2	contribution	contribution	NN
cord-000248-zueoyesj	637	3	of	of	IN
cord-000248-zueoyesj	637	4	the	the	DT
cord-000248-zueoyesj	637	5	loss	loss	NN
cord-000248-zueoyesj	637	6	of	of	IN
cord-000248-zueoyesj	637	7	these	these	DT
cord-000248-zueoyesj	637	8	integrins	integrin	NNS
cord-000248-zueoyesj	637	9	and	and	CC
cord-000248-zueoyesj	637	10	the	the	DT
cord-000248-zueoyesj	637	11	subsequent	subsequent	JJ
cord-000248-zueoyesj	637	12	derived	derive	VBN
cord-000248-zueoyesj	637	13	impairment	impairment	NN
cord-000248-zueoyesj	637	14	on	on	IN
cord-000248-zueoyesj	637	15	cell	cell	NN
cord-000248-zueoyesj	637	16	adhesion	adhesion	NN
cord-000248-zueoyesj	637	17	has	have	VBZ
cord-000248-zueoyesj	637	18	been	be	VBN
cord-000248-zueoyesj	637	19	reported	report	VBN
cord-000248-zueoyesj	637	20	in	in	IN
cord-000248-zueoyesj	637	21	several	several	JJ
cord-000248-zueoyesj	637	22	tumours	tumour	NNS
cord-000248-zueoyesj	637	23	.	.	.
cord-000248-zueoyesj	638	1	Ren	Ren	NNP
cord-000248-zueoyesj	638	2	et	et	NNP
cord-000248-zueoyesj	638	3	al	al	NNP
cord-000248-zueoyesj	638	4	.	.	.
cord-000248-zueoyesj	639	1	in	in	IN
cord-000248-zueoyesj	639	2	[	[	-LRB-
cord-000248-zueoyesj	639	3	598	598	CD
cord-000248-zueoyesj	639	4	]	]	-RRB-
cord-000248-zueoyesj	639	5	report	report	NN
cord-000248-zueoyesj	639	6	that	that	IN
cord-000248-zueoyesj	639	7	'	'	''
cord-000248-zueoyesj	639	8	'	'	``
cord-000248-zueoyesj	639	9	Focal	focal	JJ
cord-000248-zueoyesj	639	10	or	or	CC
cord-000248-zueoyesj	639	11	no	no	DT
cord-000248-zueoyesj	639	12	integrin	integrin	RB
cord-000248-zueoyesj	639	13	alpha	alpha	NN
cord-000248-zueoyesj	639	14	7	7	CD
cord-000248-zueoyesj	639	15	eexpression	eexpression	NN
cord-000248-zueoyesj	639	16	in	in	IN
cord-000248-zueoyesj	639	17	human	human	JJ
cord-000248-zueoyesj	639	18	prostate	prostate	NN
cord-000248-zueoyesj	639	19	cancer	cancer	NN
cord-000248-zueoyesj	639	20	and	and	CC
cord-000248-zueoyesj	639	21	soft	soft	JJ
cord-000248-zueoyesj	639	22	tissue	tissue	NN
cord-000248-zueoyesj	639	23	leiomyosarcoma	leiomyosarcoma	NNP
cord-000248-zueoyesj	639	24	was	be	VBD
cord-000248-zueoyesj	639	25	associated	associate	VBN
cord-000248-zueoyesj	639	26	with	with	IN
cord-000248-zueoyesj	639	27	a	a	DT
cord-000248-zueoyesj	639	28	reduction	reduction	NN
cord-000248-zueoyesj	639	29	of	of	IN
cord-000248-zueoyesj	639	30	metastasis	metastasis	NN
cord-000248-zueoyesj	639	31	-	-	HYPH
cord-000248-zueoyesj	639	32	free	free	JJ
cord-000248-zueoyesj	639	33	survival	survival	NN
cord-000248-zueoyesj	639	34	(	(	-LRB-
cord-000248-zueoyesj	639	35	for	for	IN
cord-000248-zueoyesj	639	36	example	example	NN
cord-000248-zueoyesj	639	37	,	,	,
cord-000248-zueoyesj	639	38	for	for	IN
cord-000248-zueoyesj	639	39	prostate	prostate	NN
cord-000248-zueoyesj	639	40	cancer	cancer	NN
cord-000248-zueoyesj	639	41	with	with	IN
cord-000248-zueoyesj	639	42	focal	focal	JJ
cord-000248-zueoyesj	639	43	or	or	CC
cord-000248-zueoyesj	639	44	no	no	DT
cord-000248-zueoyesj	639	45	expression	expression	NN
cord-000248-zueoyesj	639	46	,	,	,
cord-000248-zueoyesj	639	47	5-year	5-year	CD
cord-000248-zueoyesj	639	48	metastasis	metastasis	NN
cord-000248-zueoyesj	639	49	-	-	HYPH
cord-000248-zueoyesj	639	50	free	free	JJ
cord-000248-zueoyesj	639	51	survival	survival	NN
cord-000248-zueoyesj	639	52	was	be	VBD
cord-000248-zueoyesj	639	53	32	32	CD
cord-000248-zueoyesj	639	54	%	%	NN
cord-000248-zueoyesj	639	55	,	,	,
cord-000248-zueoyesj	639	56	95	95	CD
cord-000248-zueoyesj	639	57	%	%	NN
cord-000248-zueoyesj	639	58	CI	ci	NN
cord-000248-zueoyesj	639	59	=	=	SYM
cord-000248-zueoyesj	639	60	24.4	24.4	CD
cord-000248-zueoyesj	639	61	%	%	NN
cord-000248-zueoyesj	639	62	to	to	IN
cord-000248-zueoyesj	639	63	40.3	40.3	CD
cord-000248-zueoyesj	639	64	%	%	NN
cord-000248-zueoyesj	639	65	,	,	,
cord-000248-zueoyesj	639	66	and	and	CC
cord-000248-zueoyesj	639	67	for	for	IN
cord-000248-zueoyesj	639	68	prostate	prostate	NN
cord-000248-zueoyesj	639	69	cancer	cancer	NN
cord-000248-zueoyesj	639	70	with	with	IN
cord-000248-zueoyesj	639	71	at	at	IN
cord-000248-zueoyesj	639	72	least	least	JJS
cord-000248-zueoyesj	639	73	weak	weak	JJ
cord-000248-zueoyesj	639	74	expression	expression	NN
cord-000248-zueoyesj	639	75	,	,	,
cord-000248-zueoyesj	639	76	it	-PRON-	PRP
cord-000248-zueoyesj	639	77	was	be	VBD
cord-000248-zueoyesj	639	78	85	85	CD
cord-000248-zueoyesj	639	79	%	%	NN
cord-000248-zueoyesj	639	80	,	,	,
cord-000248-zueoyesj	639	81	95	95	CD
cord-000248-zueoyesj	639	82	%	%	NN
cord-000248-zueoyesj	639	83	CI	ci	NN
cord-000248-zueoyesj	639	84	=	=	SYM
cord-000248-zueoyesj	639	85	79	79	CD
cord-000248-zueoyesj	639	86	%	%	NN
cord-000248-zueoyesj	639	87	to	to	IN
cord-000248-zueoyesj	639	88	91	91	CD
cord-000248-zueoyesj	639	89	%	%	NN
cord-000248-zueoyesj	639	90	;	;	:
cord-000248-zueoyesj	639	91	p	p	NN
cord-000248-zueoyesj	639	92	-	-	HYPH
cord-000248-zueoyesj	639	93	value,.001	value,.001	JJ
cord-000248-zueoyesj	639	94	)	)	-RRB-
cord-000248-zueoyesj	639	95	'	'	''
cord-000248-zueoyesj	639	96	'	'	''
cord-000248-zueoyesj	639	97	.	.	.
cord-000248-zueoyesj	639	98	''	''	''
cord-000248-zueoyesj	640	1	Any	any	DT
cord-000248-zueoyesj	640	2	method	method	NN
cord-000248-zueoyesj	640	3	involving	involve	VBG
cord-000248-zueoyesj	640	4	the	the	DT
cord-000248-zueoyesj	640	5	notion	notion	NN
cord-000248-zueoyesj	640	6	of	of	IN
cord-000248-zueoyesj	640	7	entropy	entropy	NN
cord-000248-zueoyesj	640	8	,	,	,
cord-000248-zueoyesj	640	9	the	the	DT
cord-000248-zueoyesj	640	10	very	very	JJ
cord-000248-zueoyesj	640	11	existence	existence	NN
cord-000248-zueoyesj	640	12	of	of	IN
cord-000248-zueoyesj	640	13	which	which	WDT
cord-000248-zueoyesj	640	14	depends	depend	VBZ
cord-000248-zueoyesj	640	15	on	on	IN
cord-000248-zueoyesj	640	16	the	the	DT
cord-000248-zueoyesj	640	17	second	second	JJ
cord-000248-zueoyesj	640	18	law	law	NN
cord-000248-zueoyesj	640	19	of	of	IN
cord-000248-zueoyesj	640	20	thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	640	21	,	,	,
cord-000248-zueoyesj	640	22	will	will	MD
cord-000248-zueoyesj	640	23	doubtless	doubtless	RB
cord-000248-zueoyesj	640	24	seem	seem	VB
cord-000248-zueoyesj	640	25	to	to	IN
cord-000248-zueoyesj	640	26	many	many	JJ
cord-000248-zueoyesj	640	27	far	far	RB
cord-000248-zueoyesj	640	28	-	-	HYPH
cord-000248-zueoyesj	640	29	fetched	fetch	VBN
cord-000248-zueoyesj	640	30	,	,	,
cord-000248-zueoyesj	640	31	and	and	CC
cord-000248-zueoyesj	640	32	may	may	MD
cord-000248-zueoyesj	640	33	repel	repel	VB
cord-000248-zueoyesj	640	34	beginners	beginner	NNS
cord-000248-zueoyesj	640	35	as	as	IN
cord-000248-zueoyesj	640	36	obscure	obscure	JJ
cord-000248-zueoyesj	640	37	and	and	CC
cord-000248-zueoyesj	640	38	difficult	difficult	JJ
cord-000248-zueoyesj	640	39	of	of	IN
cord-000248-zueoyesj	640	40	comprehension	comprehension	NN
cord-000248-zueoyesj	640	41	.	.	.
cord-000248-zueoyesj	640	42	'	'	''
cord-000248-zueoyesj	640	43	'	'	''
cord-000248-zueoyesj	641	1	Willard	Willard	NNP
cord-000248-zueoyesj	641	2	Gibbs	Gibbs	NNP
cord-000248-zueoyesj	641	3	,	,	,
cord-000248-zueoyesj	641	4	Graphical	Graphical	NNP
cord-000248-zueoyesj	641	5	Methods	Methods	NNPS
cord-000248-zueoyesj	641	6	in	in	IN
cord-000248-zueoyesj	641	7	the	the	DT
cord-000248-zueoyesj	641	8	Thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	641	9	of	of	IN
cord-000248-zueoyesj	641	10	Fluids	fluid	NNS
cord-000248-zueoyesj	641	11	,	,	,
cord-000248-zueoyesj	641	12	(	(	-LRB-
cord-000248-zueoyesj	641	13	1873	1873	CD
cord-000248-zueoyesj	641	14	)	)	-RRB-
cord-000248-zueoyesj	642	1	The	the	DT
cord-000248-zueoyesj	642	2	changes	change	NNS
cord-000248-zueoyesj	642	3	of	of	IN
cord-000248-zueoyesj	642	4	the	the	DT
cord-000248-zueoyesj	642	5	Normalized	Normalized	NNP
cord-000248-zueoyesj	642	6	Shannon	Shannon	NNP
cord-000248-zueoyesj	642	7	Entropy	Entropy	NNP
cord-000248-zueoyesj	642	8	and	and	CC
cord-000248-zueoyesj	642	9	Statistical	Statistical	NNP
cord-000248-zueoyesj	642	10	Complexity	Complexity	NNP
cord-000248-zueoyesj	642	11	of	of	IN
cord-000248-zueoyesj	642	12	the	the	DT
cord-000248-zueoyesj	642	13	gene	gene	NN
cord-000248-zueoyesj	642	14	expression	expression	NN
cord-000248-zueoyesj	642	15	profile	profile	NN
cord-000248-zueoyesj	642	16	of	of	IN
cord-000248-zueoyesj	642	17	a	a	DT
cord-000248-zueoyesj	642	18	cancer	cancer	NN
cord-000248-zueoyesj	642	19	cell	cell	NN
cord-000248-zueoyesj	642	20	are	be	VBP
cord-000248-zueoyesj	642	21	associated	associate	VBN
cord-000248-zueoyesj	642	22	with	with	IN
cord-000248-zueoyesj	642	23	the	the	DT
cord-000248-zueoyesj	642	24	gradual	gradual	JJ
cord-000248-zueoyesj	642	25	deterioration	deterioration	NN
cord-000248-zueoyesj	642	26	of	of	IN
cord-000248-zueoyesj	642	27	genome	genome	NN
cord-000248-zueoyesj	642	28	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	642	29	information	information	NN
cord-000248-zueoyesj	642	30	content	content	NN
cord-000248-zueoyesj	642	31	due	due	IN
cord-000248-zueoyesj	642	32	to	to	IN
cord-000248-zueoyesj	642	33	the	the	DT
cord-000248-zueoyesj	642	34	modification	modification	NN
cord-000248-zueoyesj	642	35	of	of	IN
cord-000248-zueoyesj	642	36	its	-PRON-	PRP$
cord-000248-zueoyesj	642	37	structural	structural	JJ
cord-000248-zueoyesj	642	38	and	and	CC
cord-000248-zueoyesj	642	39	functional	functional	JJ
cord-000248-zueoyesj	642	40	integrity	integrity	NN
cord-000248-zueoyesj	642	41	during	during	IN
cord-000248-zueoyesj	642	42	disease	disease	NN
cord-000248-zueoyesj	642	43	progression	progression	NN
cord-000248-zueoyesj	642	44	.	.	.
cord-000248-zueoyesj	643	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	643	2	results	result	NNS
cord-000248-zueoyesj	643	3	clearly	clearly	RB
cord-000248-zueoyesj	643	4	suggest	suggest	VBP
cord-000248-zueoyesj	643	5	that	that	IN
cord-000248-zueoyesj	643	6	we	-PRON-	PRP
cord-000248-zueoyesj	643	7	can	can	MD
cord-000248-zueoyesj	643	8	track	track	VB
cord-000248-zueoyesj	643	9	the	the	DT
cord-000248-zueoyesj	643	10	cancer	cancer	NN
cord-000248-zueoyesj	643	11	cell	cell	NN
cord-000248-zueoyesj	643	12	's	's	POS
cord-000248-zueoyesj	643	13	progression	progression	NN
cord-000248-zueoyesj	643	14	by	by	IN
cord-000248-zueoyesj	643	15	following	follow	VBG
cord-000248-zueoyesj	643	16	observable	observable	JJ
cord-000248-zueoyesj	643	17	changes	change	NNS
cord-000248-zueoyesj	643	18	in	in	IN
cord-000248-zueoyesj	643	19	the	the	DT
cord-000248-zueoyesj	643	20	Shannon	Shannon	NNP
cord-000248-zueoyesj	643	21	Entropy	Entropy	NNP
cord-000248-zueoyesj	643	22	and	and	CC
cord-000248-zueoyesj	643	23	,	,	,
cord-000248-zueoyesj	643	24	in	in	IN
cord-000248-zueoyesj	643	25	particular	particular	JJ
cord-000248-zueoyesj	643	26	,	,	,
cord-000248-zueoyesj	643	27	by	by	IN
cord-000248-zueoyesj	643	28	employing	employ	VBG
cord-000248-zueoyesj	643	29	the	the	DT
cord-000248-zueoyesj	643	30	Jensen	Jensen	NNP
cord-000248-zueoyesj	643	31	-	-	HYPH
cord-000248-zueoyesj	643	32	Shannon	Shannon	NNP
cord-000248-zueoyesj	643	33	Divergence	Divergence	NNP
cord-000248-zueoyesj	643	34	of	of	IN
cord-000248-zueoyesj	643	35	the	the	DT
cord-000248-zueoyesj	643	36	gene	gene	NN
cord-000248-zueoyesj	643	37	expression	expression	NN
cord-000248-zueoyesj	643	38	profile	profile	NN
cord-000248-zueoyesj	643	39	of	of	IN
cord-000248-zueoyesj	643	40	a	a	DT
cord-000248-zueoyesj	643	41	sample	sample	NN
cord-000248-zueoyesj	643	42	to	to	IN
cord-000248-zueoyesj	643	43	the	the	DT
cord-000248-zueoyesj	643	44	normal	normal	JJ
cord-000248-zueoyesj	643	45	expression	expression	NN
cord-000248-zueoyesj	643	46	profile	profile	NN
cord-000248-zueoyesj	643	47	.	.	.
cord-000248-zueoyesj	644	1	We	-PRON-	PRP
cord-000248-zueoyesj	644	2	have	have	VBP
cord-000248-zueoyesj	644	3	also	also	RB
cord-000248-zueoyesj	644	4	shown	show	VBN
cord-000248-zueoyesj	644	5	if	if	IN
cord-000248-zueoyesj	644	6	an	an	DT
cord-000248-zueoyesj	644	7	average	average	JJ
cord-000248-zueoyesj	644	8	expression	expression	NN
cord-000248-zueoyesj	644	9	profile	profile	NN
cord-000248-zueoyesj	644	10	of	of	IN
cord-000248-zueoyesj	644	11	some	some	DT
cord-000248-zueoyesj	644	12	state	state	NN
cord-000248-zueoyesj	644	13	of	of	IN
cord-000248-zueoyesj	644	14	interest	interest	NN
cord-000248-zueoyesj	644	15	can	can	MD
cord-000248-zueoyesj	644	16	be	be	VB
cord-000248-zueoyesj	644	17	properly	properly	RB
cord-000248-zueoyesj	644	18	defined	define	VBN
cord-000248-zueoyesj	644	19	(	(	-LRB-
cord-000248-zueoyesj	644	20	i.e.	i.e.	FW
cord-000248-zueoyesj	644	21	distant	distant	JJ
cord-000248-zueoyesj	644	22	metastasis	metastasis	NN
cord-000248-zueoyesj	644	23	)	)	-RRB-
cord-000248-zueoyesj	645	1	then	then	RB
cord-000248-zueoyesj	645	2	the	the	DT
cord-000248-zueoyesj	645	3	Jensen	Jensen	NNP
cord-000248-zueoyesj	645	4	-	-	HYPH
cord-000248-zueoyesj	645	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	645	6	Divergence	Divergence	NNP
cord-000248-zueoyesj	645	7	can	can	MD
cord-000248-zueoyesj	645	8	help	help	VB
cord-000248-zueoyesj	645	9	us	-PRON-	PRP
cord-000248-zueoyesj	645	10	to	to	TO
cord-000248-zueoyesj	645	11	identify	identify	VB
cord-000248-zueoyesj	645	12	which	which	WDT
cord-000248-zueoyesj	645	13	probes	probe	NNS
cord-000248-zueoyesj	645	14	best	well	RBS
cord-000248-zueoyesj	645	15	correlate	correlate	VB
cord-000248-zueoyesj	645	16	with	with	IN
cord-000248-zueoyesj	645	17	these	these	DT
cord-000248-zueoyesj	645	18	measures	measure	NNS
cord-000248-zueoyesj	645	19	resulting	result	VBG
cord-000248-zueoyesj	645	20	in	in	IN
cord-000248-zueoyesj	645	21	useful	useful	JJ
cord-000248-zueoyesj	645	22	biomarkers	biomarker	NNS
cord-000248-zueoyesj	645	23	.	.	.
cord-000248-zueoyesj	646	1	Before	before	IN
cord-000248-zueoyesj	646	2	any	any	DT
cord-000248-zueoyesj	646	3	thermodynamical	thermodynamical	JJ
cord-000248-zueoyesj	646	4	consideration	consideration	NN
cord-000248-zueoyesj	646	5	could	could	MD
cord-000248-zueoyesj	646	6	be	be	VB
cord-000248-zueoyesj	646	7	discussed	discuss	VBN
cord-000248-zueoyesj	646	8	,	,	,
cord-000248-zueoyesj	646	9	we	-PRON-	PRP
cord-000248-zueoyesj	646	10	note	note	VBP
cord-000248-zueoyesj	646	11	that	that	IN
cord-000248-zueoyesj	646	12	there	there	EX
cord-000248-zueoyesj	646	13	is	be	VBZ
cord-000248-zueoyesj	646	14	a	a	DT
cord-000248-zueoyesj	646	15	clear	clear	JJ
cord-000248-zueoyesj	646	16	and	and	CC
cord-000248-zueoyesj	646	17	objective	objective	JJ
cord-000248-zueoyesj	646	18	informational	informational	JJ
cord-000248-zueoyesj	646	19	perspective	perspective	NN
cord-000248-zueoyesj	646	20	that	that	WDT
cord-000248-zueoyesj	646	21	our	-PRON-	PRP$
cord-000248-zueoyesj	646	22	study	study	NN
cord-000248-zueoyesj	646	23	delivers	deliver	VBZ
cord-000248-zueoyesj	646	24	.	.	.
cord-000248-zueoyesj	647	1	In	in	IN
cord-000248-zueoyesj	647	2	this	this	DT
cord-000248-zueoyesj	647	3	study	study	NN
cord-000248-zueoyesj	647	4	we	-PRON-	PRP
cord-000248-zueoyesj	647	5	have	have	VBP
cord-000248-zueoyesj	647	6	chosen	choose	VBN
cord-000248-zueoyesj	647	7	to	to	TO
cord-000248-zueoyesj	647	8	position	position	VB
cord-000248-zueoyesj	647	9	ourselves	-PRON-	PRP
cord-000248-zueoyesj	647	10	as	as	IN
cord-000248-zueoyesj	647	11	the	the	DT
cord-000248-zueoyesj	647	12	'	'	``
cord-000248-zueoyesj	647	13	receivers	receiver	NNS
cord-000248-zueoyesj	647	14	'	'	POS
cord-000248-zueoyesj	647	15	of	of	IN
cord-000248-zueoyesj	647	16	a	a	DT
cord-000248-zueoyesj	647	17	'	'	``
cord-000248-zueoyesj	647	18	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	647	19	message	message	NN
cord-000248-zueoyesj	647	20	'	'	''
cord-000248-zueoyesj	647	21	.	.	.
cord-000248-zueoyesj	648	1	In	in	IN
cord-000248-zueoyesj	648	2	this	this	DT
cord-000248-zueoyesj	648	3	experimental	experimental	JJ
cord-000248-zueoyesj	648	4	perspective	perspective	NN
cord-000248-zueoyesj	648	5	the	the	DT
cord-000248-zueoyesj	648	6	tumor	tumor	NN
cord-000248-zueoyesj	648	7	tissue	tissue	NN
cord-000248-zueoyesj	648	8	is	be	VBZ
cord-000248-zueoyesj	648	9	the	the	DT
cord-000248-zueoyesj	648	10	'	'	``
cord-000248-zueoyesj	648	11	sender	sender	NN
cord-000248-zueoyesj	648	12	'	'	''
cord-000248-zueoyesj	648	13	(	(	-LRB-
cord-000248-zueoyesj	648	14	the	the	DT
cord-000248-zueoyesj	648	15	source	source	NN
cord-000248-zueoyesj	648	16	of	of	IN
cord-000248-zueoyesj	648	17	information	information	NN
cord-000248-zueoyesj	648	18	)	)	-RRB-
cord-000248-zueoyesj	648	19	and	and	CC
cord-000248-zueoyesj	648	20	the	the	DT
cord-000248-zueoyesj	648	21	high	high	JJ
cord-000248-zueoyesj	648	22	-	-	HYPH
cord-000248-zueoyesj	648	23	throughput	throughput	NN
cord-000248-zueoyesj	648	24	technology	technology	NN
cord-000248-zueoyesj	648	25	(	(	-LRB-
cord-000248-zueoyesj	648	26	gene	gene	NN
cord-000248-zueoyesj	648	27	expression	expression	NN
cord-000248-zueoyesj	648	28	microarrays	microarray	NNS
cord-000248-zueoyesj	648	29	in	in	IN
cord-000248-zueoyesj	648	30	this	this	DT
cord-000248-zueoyesj	648	31	case	case	NN
cord-000248-zueoyesj	648	32	)	)	-RRB-
cord-000248-zueoyesj	648	33	can	can	MD
cord-000248-zueoyesj	648	34	be	be	VB
cord-000248-zueoyesj	648	35	regarded	regard	VBN
cord-000248-zueoyesj	648	36	as	as	IN
cord-000248-zueoyesj	648	37	the	the	DT
cord-000248-zueoyesj	648	38	transmission	transmission	NN
cord-000248-zueoyesj	648	39	medium	medium	NN
cord-000248-zueoyesj	648	40	(	(	-LRB-
cord-000248-zueoyesj	648	41	providing	provide	VBG
cord-000248-zueoyesj	648	42	noise	noise	NN
cord-000248-zueoyesj	648	43	and	and	CC
cord-000248-zueoyesj	648	44	distortion	distortion	NN
cord-000248-zueoyesj	648	45	)	)	-RRB-
cord-000248-zueoyesj	648	46	.	.	.
cord-000248-zueoyesj	649	1	As	as	IN
cord-000248-zueoyesj	649	2	we	-PRON-	PRP
cord-000248-zueoyesj	649	3	explain	explain	VBP
cord-000248-zueoyesj	649	4	in	in	IN
cord-000248-zueoyesj	649	5	the	the	DT
cord-000248-zueoyesj	649	6	'	'	``
cord-000248-zueoyesj	649	7	Materials	Materials	NNPS
cord-000248-zueoyesj	649	8	and	and	CC
cord-000248-zueoyesj	649	9	Methods	Methods	NNPS
cord-000248-zueoyesj	649	10	'	'	POS
cord-000248-zueoyesj	649	11	section	section	NN
cord-000248-zueoyesj	649	12	,	,	,
cord-000248-zueoyesj	649	13	the	the	DT
cord-000248-zueoyesj	649	14	Shannon	Shannon	NNP
cord-000248-zueoyesj	649	15	Entropy	Entropy	NNP
cord-000248-zueoyesj	649	16	of	of	IN
cord-000248-zueoyesj	649	17	a	a	DT
cord-000248-zueoyesj	649	18	gene	gene	NN
cord-000248-zueoyesj	649	19	expression	expression	NN
cord-000248-zueoyesj	649	20	profile	profile	NN
cord-000248-zueoyesj	649	21	is	be	VBZ
cord-000248-zueoyesj	649	22	the	the	DT
cord-000248-zueoyesj	649	23	average	average	JJ
cord-000248-zueoyesj	649	24	expected	expect	VBN
cord-000248-zueoyesj	649	25	surprisal	surprisal	NN
cord-000248-zueoyesj	649	26	of	of	IN
cord-000248-zueoyesj	649	27	that	that	DT
cord-000248-zueoyesj	649	28	profile	profile	NN
cord-000248-zueoyesj	649	29	understood	understand	VBD
cord-000248-zueoyesj	649	30	as	as	IN
cord-000248-zueoyesj	649	31	a	a	DT
cord-000248-zueoyesj	649	32	message	message	NN
cord-000248-zueoyesj	649	33	.	.	.
cord-000248-zueoyesj	650	1	The	the	DT
cord-000248-zueoyesj	650	2	Normalized	Normalized	NNP
cord-000248-zueoyesj	650	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	650	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	650	5	makes	make	VBZ
cord-000248-zueoyesj	650	6	this	this	DT
cord-000248-zueoyesj	650	7	surprisal	surprisal	NN
cord-000248-zueoyesj	650	8	an	an	DT
cord-000248-zueoyesj	650	9	intensive	intensive	JJ
cord-000248-zueoyesj	650	10	measure	measure	NN
cord-000248-zueoyesj	650	11	and	and	CC
cord-000248-zueoyesj	650	12	the	the	DT
cord-000248-zueoyesj	650	13	correlation	correlation	NN
cord-000248-zueoyesj	650	14	of	of	IN
cord-000248-zueoyesj	650	15	the	the	DT
cord-000248-zueoyesj	650	16	gene	gene	NN
cord-000248-zueoyesj	650	17	expression	expression	NN
cord-000248-zueoyesj	650	18	patterns	pattern	NNS
cord-000248-zueoyesj	650	19	across	across	IN
cord-000248-zueoyesj	650	20	samples	sample	NNS
cord-000248-zueoyesj	650	21	with	with	IN
cord-000248-zueoyesj	650	22	this	this	DT
cord-000248-zueoyesj	650	23	measure	measure	NN
cord-000248-zueoyesj	650	24	can	can	MD
cord-000248-zueoyesj	650	25	deliver	deliver	VB
cord-000248-zueoyesj	650	26	useful	useful	JJ
cord-000248-zueoyesj	650	27	biomarkers	biomarker	NNS
cord-000248-zueoyesj	650	28	to	to	TO
cord-000248-zueoyesj	650	29	track	track	VB
cord-000248-zueoyesj	650	30	the	the	DT
cord-000248-zueoyesj	650	31	progression	progression	NN
cord-000248-zueoyesj	650	32	of	of	IN
cord-000248-zueoyesj	650	33	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	650	34	change	change	NN
cord-000248-zueoyesj	650	35	.	.	.
cord-000248-zueoyesj	651	1	After	after	IN
cord-000248-zueoyesj	651	2	normalization	normalization	NN
cord-000248-zueoyesj	651	3	,	,	,
cord-000248-zueoyesj	651	4	we	-PRON-	PRP
cord-000248-zueoyesj	651	5	have	have	VBP
cord-000248-zueoyesj	651	6	a	a	DT
cord-000248-zueoyesj	651	7	measure	measure	NN
cord-000248-zueoyesj	651	8	that	that	WDT
cord-000248-zueoyesj	651	9	does	do	VBZ
cord-000248-zueoyesj	651	10	not	not	RB
cord-000248-zueoyesj	651	11	depend	depend	VB
cord-000248-zueoyesj	651	12	of	of	IN
cord-000248-zueoyesj	651	13	the	the	DT
cord-000248-zueoyesj	651	14	number	number	NN
cord-000248-zueoyesj	651	15	of	of	IN
cord-000248-zueoyesj	651	16	probes	probe	NNS
cord-000248-zueoyesj	651	17	of	of	IN
cord-000248-zueoyesj	651	18	the	the	DT
cord-000248-zueoyesj	651	19	high	high	JJ
cord-000248-zueoyesj	651	20	-	-	HYPH
cord-000248-zueoyesj	651	21	throughput	throughput	NN
cord-000248-zueoyesj	651	22	technology	technology	NN
cord-000248-zueoyesj	651	23	,	,	,
cord-000248-zueoyesj	651	24	although	although	RB
cord-000248-zueoyesj	651	25	,	,	,
cord-000248-zueoyesj	651	26	it	-PRON-	PRP
cord-000248-zueoyesj	651	27	obviously	obviously	RB
cord-000248-zueoyesj	651	28	does	do	VBZ
cord-000248-zueoyesj	651	29	depend	depend	VB
cord-000248-zueoyesj	651	30	on	on	IN
cord-000248-zueoyesj	651	31	the	the	DT
cord-000248-zueoyesj	651	32	type	type	NN
cord-000248-zueoyesj	651	33	of	of	IN
cord-000248-zueoyesj	651	34	probes	probe	NNS
cord-000248-zueoyesj	651	35	used	use	VBN
cord-000248-zueoyesj	651	36	.	.	.
cord-000248-zueoyesj	652	1	We	-PRON-	PRP
cord-000248-zueoyesj	652	2	believe	believe	VBP
cord-000248-zueoyesj	652	3	that	that	IN
cord-000248-zueoyesj	652	4	the	the	DT
cord-000248-zueoyesj	652	5	readers	reader	NNS
cord-000248-zueoyesj	652	6	may	may	MD
cord-000248-zueoyesj	652	7	have	have	VB
cord-000248-zueoyesj	652	8	already	already	RB
cord-000248-zueoyesj	652	9	noticed	notice	VBN
cord-000248-zueoyesj	652	10	an	an	DT
cord-000248-zueoyesj	652	11	apparent	apparent	JJ
cord-000248-zueoyesj	652	12	paradox	paradox	NN
cord-000248-zueoyesj	652	13	.	.	.
cord-000248-zueoyesj	653	1	While	while	IN
cord-000248-zueoyesj	653	2	some	some	DT
cord-000248-zueoyesj	653	3	researchers	researcher	NNS
cord-000248-zueoyesj	653	4	understand	understand	VBP
cord-000248-zueoyesj	653	5	cancer	cancer	NN
cord-000248-zueoyesj	653	6	progression	progression	NN
cord-000248-zueoyesj	653	7	as	as	IN
cord-000248-zueoyesj	653	8	a	a	DT
cord-000248-zueoyesj	653	9	mechanism	mechanism	NN
cord-000248-zueoyesj	653	10	that	that	WDT
cord-000248-zueoyesj	653	11	increases	increase	VBZ
cord-000248-zueoyesj	653	12	entropy	entropy	NN
cord-000248-zueoyesj	653	13	,	,	,
cord-000248-zueoyesj	653	14	we	-PRON-	PRP
cord-000248-zueoyesj	653	15	actually	actually	RB
cord-000248-zueoyesj	653	16	observe	observe	VBP
cord-000248-zueoyesj	653	17	a	a	DT
cord-000248-zueoyesj	653	18	reduction	reduction	NN
cord-000248-zueoyesj	653	19	of	of	IN
cord-000248-zueoyesj	653	20	Normalized	Normalized	NNP
cord-000248-zueoyesj	653	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	653	22	Entropy	Entropy	NNP
cord-000248-zueoyesj	653	23	in	in	IN
cord-000248-zueoyesj	653	24	this	this	DT
cord-000248-zueoyesj	653	25	work	work	NN
cord-000248-zueoyesj	653	26	.	.	.
cord-000248-zueoyesj	654	1	This	this	DT
cord-000248-zueoyesj	654	2	means	mean	VBZ
cord-000248-zueoyesj	654	3	that	that	IN
cord-000248-zueoyesj	654	4	our	-PRON-	PRP$
cord-000248-zueoyesj	654	5	normalized	normalized	JJ
cord-000248-zueoyesj	654	6	average	average	NN
cord-000248-zueoyesj	654	7	expected	expect	VBN
cord-000248-zueoyesj	654	8	surprisal	surprisal	NNP
cord-000248-zueoyesj	654	9	,	,	,
cord-000248-zueoyesj	654	10	as	as	IN
cord-000248-zueoyesj	654	11	receivers	receiver	NNS
cord-000248-zueoyesj	654	12	of	of	IN
cord-000248-zueoyesj	654	13	the	the	DT
cord-000248-zueoyesj	654	14	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	654	15	message	message	NN
cord-000248-zueoyesj	654	16	,	,	,
cord-000248-zueoyesj	654	17	is	be	VBZ
cord-000248-zueoyesj	654	18	smaller	small	JJR
cord-000248-zueoyesj	654	19	.	.	.
cord-000248-zueoyesj	655	1	We	-PRON-	PRP
cord-000248-zueoyesj	655	2	must	must	MD
cord-000248-zueoyesj	655	3	then	then	RB
cord-000248-zueoyesj	655	4	discuss	discuss	VB
cord-000248-zueoyesj	655	5	the	the	DT
cord-000248-zueoyesj	655	6	physical	physical	JJ
cord-000248-zueoyesj	655	7	meaning	meaning	NN
cord-000248-zueoyesj	655	8	of	of	IN
cord-000248-zueoyesj	655	9	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	655	10	entropy	entropy	NN
cord-000248-zueoyesj	655	11	,	,	,
cord-000248-zueoyesj	655	12	its	-PRON-	PRP$
cord-000248-zueoyesj	655	13	current	current	JJ
cord-000248-zueoyesj	655	14	use	use	NN
cord-000248-zueoyesj	655	15	in	in	IN
cord-000248-zueoyesj	655	16	systems	system	NNS
cord-000248-zueoyesj	655	17	biology	biology	NN
cord-000248-zueoyesj	655	18	and	and	CC
cord-000248-zueoyesj	655	19	cancer	cancer	NN
cord-000248-zueoyesj	655	20	research	research	NN
cord-000248-zueoyesj	655	21	genetics	genetic	NNS
cord-000248-zueoyesj	655	22	and	and	CC
cord-000248-zueoyesj	655	23	the	the	DT
cord-000248-zueoyesj	655	24	informational	informational	JJ
cord-000248-zueoyesj	655	25	measure	measure	NN
cord-000248-zueoyesj	655	26	we	-PRON-	PRP
cord-000248-zueoyesj	655	27	use	use	VBP
cord-000248-zueoyesj	655	28	in	in	IN
cord-000248-zueoyesj	655	29	this	this	DT
cord-000248-zueoyesj	655	30	paper	paper	NN
cord-000248-zueoyesj	655	31	to	to	TO
cord-000248-zueoyesj	655	32	clarify	clarify	VB
cord-000248-zueoyesj	655	33	these	these	DT
cord-000248-zueoyesj	655	34	notions	notion	NNS
cord-000248-zueoyesj	655	35	in	in	IN
cord-000248-zueoyesj	655	36	this	this	DT
cord-000248-zueoyesj	655	37	context	context	NN
cord-000248-zueoyesj	655	38	.	.	.
cord-000248-zueoyesj	656	1	In	in	IN
cord-000248-zueoyesj	656	2	biomedical	biomedical	JJ
cord-000248-zueoyesj	656	3	research	research	NN
cord-000248-zueoyesj	656	4	there	there	EX
cord-000248-zueoyesj	656	5	exists	exist	VBZ
cord-000248-zueoyesj	656	6	a	a	DT
cord-000248-zueoyesj	656	7	certain	certain	JJ
cord-000248-zueoyesj	656	8	consensus	consensus	NN
cord-000248-zueoyesj	656	9	among	among	IN
cord-000248-zueoyesj	656	10	cancer	cancer	NN
cord-000248-zueoyesj	656	11	researchers	researcher	NNS
cord-000248-zueoyesj	656	12	that	that	IN
cord-000248-zueoyesj	656	13	genetic	genetic	JJ
cord-000248-zueoyesj	656	14	instability	instability	NN
cord-000248-zueoyesj	656	15	or	or	CC
cord-000248-zueoyesj	656	16	'	'	''
cord-000248-zueoyesj	656	17	'	'	``
cord-000248-zueoyesj	656	18	mutability	mutability	NN
cord-000248-zueoyesj	656	19	'	'	''
cord-000248-zueoyesj	656	20	'	'	''
cord-000248-zueoyesj	656	21	is	be	VBZ
cord-000248-zueoyesj	656	22	a	a	DT
cord-000248-zueoyesj	656	23	major	major	JJ
cord-000248-zueoyesj	656	24	critical	critical	JJ
cord-000248-zueoyesj	656	25	force	force	NN
cord-000248-zueoyesj	656	26	of	of	IN
cord-000248-zueoyesj	656	27	cancer	cancer	NN
cord-000248-zueoyesj	656	28	progression	progression	NN
cord-000248-zueoyesj	656	29	,	,	,
cord-000248-zueoyesj	656	30	but	but	CC
cord-000248-zueoyesj	656	31	it	-PRON-	PRP
cord-000248-zueoyesj	656	32	is	be	VBZ
cord-000248-zueoyesj	656	33	not	not	RB
cord-000248-zueoyesj	656	34	the	the	DT
cord-000248-zueoyesj	656	35	only	only	JJ
cord-000248-zueoyesj	656	36	one	one	CD
cord-000248-zueoyesj	656	37	to	to	TO
cord-000248-zueoyesj	656	38	consider	consider	VB
cord-000248-zueoyesj	656	39	.	.	.
cord-000248-zueoyesj	657	1	It	-PRON-	PRP
cord-000248-zueoyesj	657	2	is	be	VBZ
cord-000248-zueoyesj	657	3	clear	clear	JJ
cord-000248-zueoyesj	657	4	that	that	IN
cord-000248-zueoyesj	657	5	the	the	DT
cord-000248-zueoyesj	657	6	mutational	mutational	JJ
cord-000248-zueoyesj	657	7	damage	damage	NN
cord-000248-zueoyesj	657	8	of	of	IN
cord-000248-zueoyesj	657	9	key	key	JJ
cord-000248-zueoyesj	657	10	genes	gene	NNS
cord-000248-zueoyesj	657	11	(	(	-LRB-
cord-000248-zueoyesj	657	12	like	like	IN
cord-000248-zueoyesj	657	13	TP53	TP53	NNP
cord-000248-zueoyesj	657	14	,	,	,
cord-000248-zueoyesj	657	15	TERT	TERT	NNP
cord-000248-zueoyesj	657	16	,	,	,
cord-000248-zueoyesj	657	17	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	657	18	,	,	,
cord-000248-zueoyesj	657	19	RB1	RB1	NNP
cord-000248-zueoyesj	657	20	,	,	,
cord-000248-zueoyesj	657	21	etc	etc	FW
cord-000248-zueoyesj	657	22	.	.	.
cord-000248-zueoyesj	657	23	)	)	-RRB-
cord-000248-zueoyesj	657	24	,	,	,
cord-000248-zueoyesj	657	25	and	and	CC
cord-000248-zueoyesj	657	26	the	the	DT
cord-000248-zueoyesj	657	27	collective	collective	JJ
cord-000248-zueoyesj	657	28	damage	damage	NN
cord-000248-zueoyesj	657	29	inflicted	inflict	VBN
cord-000248-zueoyesj	657	30	on	on	IN
cord-000248-zueoyesj	657	31	key	key	JJ
cord-000248-zueoyesj	657	32	DNA	dna	NN
cord-000248-zueoyesj	657	33	repair	repair	NN
cord-000248-zueoyesj	657	34	mechanisms	mechanism	NNS
cord-000248-zueoyesj	657	35	(	(	-LRB-
cord-000248-zueoyesj	657	36	like	like	IN
cord-000248-zueoyesj	657	37	Nucleotide	nucleotide	NN
cord-000248-zueoyesj	657	38	-	-	HYPH
cord-000248-zueoyesj	657	39	excision	excision	NN
cord-000248-zueoyesj	657	40	repair	repair	NN
cord-000248-zueoyesj	657	41	and	and	CC
cord-000248-zueoyesj	657	42	Base	base	NN
cord-000248-zueoyesj	657	43	-	-	HYPH
cord-000248-zueoyesj	657	44	excision	excision	NN
cord-000248-zueoyesj	657	45	repair	repair	NN
cord-000248-zueoyesj	657	46	)	)	-RRB-
cord-000248-zueoyesj	657	47	collaborate	collaborate	VBP
cord-000248-zueoyesj	657	48	for	for	IN
cord-000248-zueoyesj	657	49	an	an	DT
cord-000248-zueoyesj	657	50	increasing	increase	VBG
cord-000248-zueoyesj	657	51	acceleration	acceleration	NN
cord-000248-zueoyesj	657	52	of	of	IN
cord-000248-zueoyesj	657	53	the	the	DT
cord-000248-zueoyesj	657	54	number	number	NN
cord-000248-zueoyesj	657	55	of	of	IN
cord-000248-zueoyesj	657	56	genomic	genomic	JJ
cord-000248-zueoyesj	657	57	changes	change	NNS
cord-000248-zueoyesj	657	58	.	.	.
cord-000248-zueoyesj	658	1	Sub	sub	JJ
cord-000248-zueoyesj	658	2	-	-	HYPH
cord-000248-zueoyesj	658	3	microscopic	microscopic	JJ
cord-000248-zueoyesj	658	4	alterations	alteration	NNS
cord-000248-zueoyesj	658	5	of	of	IN
cord-000248-zueoyesj	658	6	the	the	DT
cord-000248-zueoyesj	658	7	genome	genome	NN
cord-000248-zueoyesj	658	8	accumulate	accumulate	VBP
cord-000248-zueoyesj	658	9	in	in	IN
cord-000248-zueoyesj	658	10	cancer	cancer	NN
cord-000248-zueoyesj	658	11	progression	progression	NN
cord-000248-zueoyesj	658	12	in	in	IN
cord-000248-zueoyesj	658	13	an	an	DT
cord-000248-zueoyesj	658	14	irreversible	irreversible	JJ
cord-000248-zueoyesj	658	15	way	way	NN
cord-000248-zueoyesj	658	16	and	and	CC
cord-000248-zueoyesj	658	17	'	'	''
cord-000248-zueoyesj	658	18	'	'	''
cord-000248-zueoyesj	658	19	are	be	VBP
cord-000248-zueoyesj	658	20	compounded	compound	VBN
cord-000248-zueoyesj	658	21	by	by	IN
cord-000248-zueoyesj	658	22	the	the	DT
cord-000248-zueoyesj	658	23	widespread	widespread	JJ
cord-000248-zueoyesj	658	24	scrambling	scrambling	NN
cord-000248-zueoyesj	658	25	of	of	IN
cord-000248-zueoyesj	658	26	the	the	DT
cord-000248-zueoyesj	658	27	chromosome	chromosome	NN
cord-000248-zueoyesj	658	28	structure	structure	NN
cord-000248-zueoyesj	658	29	,	,	,
cord-000248-zueoyesj	658	30	and	and	CC
cord-000248-zueoyesj	658	31	thus	thus	RB
cord-000248-zueoyesj	658	32	the	the	DT
cord-000248-zueoyesj	658	33	karyotype	karyotype	NN
cord-000248-zueoyesj	658	34	,	,	,
cord-000248-zueoyesj	658	35	found	find	VBN
cord-000248-zueoyesj	658	36	in	in	IN
cord-000248-zueoyesj	658	37	cells	cell	NNS
cord-000248-zueoyesj	658	38	from	from	IN
cord-000248-zueoyesj	658	39	the	the	DT
cord-000248-zueoyesj	658	40	great	great	JJ
cord-000248-zueoyesj	658	41	majority	majority	NN
cord-000248-zueoyesj	658	42	of	of	IN
cord-000248-zueoyesj	658	43	solid	solid	JJ
cord-000248-zueoyesj	658	44	tumours	tumour	NNS
cord-000248-zueoyesj	658	45	'	'	POS
cord-000248-zueoyesj	658	46	'	'	''
cord-000248-zueoyesj	658	47	[	[	-LRB-
cord-000248-zueoyesj	658	48	599	599	CD
cord-000248-zueoyesj	658	49	]	]	-RRB-
cord-000248-zueoyesj	658	50	.	.	.
cord-000248-zueoyesj	659	1	In	in	IN
cord-000248-zueoyesj	659	2	Weinberg	Weinberg	NNP
cord-000248-zueoyesj	659	3	's	's	POS
cord-000248-zueoyesj	659	4	own	own	JJ
cord-000248-zueoyesj	659	5	words	word	NNS
cord-000248-zueoyesj	659	6	[	[	-LRB-
cord-000248-zueoyesj	659	7	599	599	CD
cord-000248-zueoyesj	659	8	]	]	-RRB-
cord-000248-zueoyesj	659	9	:	:	:
cord-000248-zueoyesj	659	10	'	'	''
cord-000248-zueoyesj	659	11	'	'	''
cord-000248-zueoyesj	659	12	we	-PRON-	PRP
cord-000248-zueoyesj	659	13	learned	learn	VBD
cord-000248-zueoyesj	659	14	that	that	IN
cord-000248-zueoyesj	659	15	this	this	DT
cord-000248-zueoyesj	659	16	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	659	17	chaos	chaos	NN
cord-000248-zueoyesj	659	18	also	also	RB
cord-000248-zueoyesj	659	19	contributes	contribute	VBZ
cord-000248-zueoyesj	659	20	this	this	DT
cord-000248-zueoyesj	659	21	progression	progression	NN
cord-000248-zueoyesj	659	22	forward	forward	RB
cord-000248-zueoyesj	659	23	'	'	''
cord-000248-zueoyesj	659	24	'	'	''
cord-000248-zueoyesj	659	25	.	.	.
cord-000248-zueoyesj	660	1	This	this	DT
cord-000248-zueoyesj	660	2	'	'	``
cord-000248-zueoyesj	660	3	'	'	``
cord-000248-zueoyesj	660	4	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	660	5	chaos	chaos	NN
cord-000248-zueoyesj	660	6	'	'	''
cord-000248-zueoyesj	660	7	'	'	''
cord-000248-zueoyesj	660	8	[	[	-LRB-
cord-000248-zueoyesj	660	9	600	600	CD
cord-000248-zueoyesj	660	10	]	]	-RRB-
cord-000248-zueoyesj	660	11	or	or	CC
cord-000248-zueoyesj	660	12	'	'	''
cord-000248-zueoyesj	660	13	'	'	''
cord-000248-zueoyesj	660	14	cancer	cancer	NN
cord-000248-zueoyesj	660	15	as	as	IN
cord-000248-zueoyesj	660	16	a	a	DT
cord-000248-zueoyesj	660	17	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	660	18	disease	disease	NN
cord-000248-zueoyesj	660	19	'	'	''
cord-000248-zueoyesj	660	20	'	'	''
cord-000248-zueoyesj	660	21	perspective	perspective	NN
cord-000248-zueoyesj	660	22	is	be	VBZ
cord-000248-zueoyesj	660	23	viewed	view	VBN
cord-000248-zueoyesj	660	24	by	by	IN
cord-000248-zueoyesj	660	25	some	some	DT
cord-000248-zueoyesj	660	26	researchers	researcher	NNS
cord-000248-zueoyesj	660	27	not	not	RB
cord-000248-zueoyesj	660	28	as	as	IN
cord-000248-zueoyesj	660	29	just	just	RB
cord-000248-zueoyesj	660	30	a	a	DT
cord-000248-zueoyesj	660	31	side	side	JJ
cord-000248-zueoyesj	660	32	consequence	consequence	NN
cord-000248-zueoyesj	660	33	of	of	IN
cord-000248-zueoyesj	660	34	mutational	mutational	JJ
cord-000248-zueoyesj	660	35	damage	damage	NN
cord-000248-zueoyesj	660	36	,	,	,
cord-000248-zueoyesj	660	37	but	but	CC
cord-000248-zueoyesj	660	38	as	as	IN
cord-000248-zueoyesj	660	39	the	the	DT
cord-000248-zueoyesj	660	40	main	main	JJ
cord-000248-zueoyesj	660	41	core	core	NN
cord-000248-zueoyesj	660	42	theme	theme	NN
cord-000248-zueoyesj	660	43	to	to	TO
cord-000248-zueoyesj	660	44	understand	understand	VB
cord-000248-zueoyesj	660	45	a	a	DT
cord-000248-zueoyesj	660	46	number	number	NN
cord-000248-zueoyesj	660	47	of	of	IN
cord-000248-zueoyesj	660	48	unexplained	unexplained	JJ
cord-000248-zueoyesj	660	49	issues	issue	NNS
cord-000248-zueoyesj	660	50	in	in	IN
cord-000248-zueoyesj	660	51	cancer	cancer	NN
cord-000248-zueoyesj	660	52	progression	progression	NN
cord-000248-zueoyesj	660	53	.	.	.
cord-000248-zueoyesj	660	54	''	''	''
cord-000248-zueoyesj	661	1	In	in	IN
cord-000248-zueoyesj	661	2	sum	sum	NN
cord-000248-zueoyesj	661	3	,	,	,
cord-000248-zueoyesj	661	4	cancer	cancer	NN
cord-000248-zueoyesj	661	5	is	be	VBZ
cord-000248-zueoyesj	661	6	caused	cause	VBN
cord-000248-zueoyesj	661	7	by	by	IN
cord-000248-zueoyesj	661	8	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	661	9	disorganization	disorganization	NN
cord-000248-zueoyesj	661	10	,	,	,
cord-000248-zueoyesj	661	11	which	which	WDT
cord-000248-zueoyesj	661	12	increases	increase	VBZ
cord-000248-zueoyesj	661	13	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	661	14	entropy	entropy	NNP
cord-000248-zueoyesj	661	15	'	'	''
cord-000248-zueoyesj	661	16	'	'	''
cord-000248-zueoyesj	662	1	[	[	-LRB-
cord-000248-zueoyesj	662	2	601	601	CD
cord-000248-zueoyesj	662	3	]	]	-RRB-
cord-000248-zueoyesj	662	4	.	.	.
cord-000248-zueoyesj	663	1	Regarding	regard	VBG
cord-000248-zueoyesj	663	2	the	the	DT
cord-000248-zueoyesj	663	3	cancer	cancer	NN
cord-000248-zueoyesj	663	4	types	type	NNS
cord-000248-zueoyesj	663	5	studied	study	VBN
cord-000248-zueoyesj	663	6	in	in	IN
cord-000248-zueoyesj	663	7	this	this	DT
cord-000248-zueoyesj	663	8	paper	paper	NN
cord-000248-zueoyesj	663	9	,	,	,
cord-000248-zueoyesj	663	10	one	one	CD
cord-000248-zueoyesj	663	11	particular	particular	JJ
cord-000248-zueoyesj	663	12	'	'	''
cord-000248-zueoyesj	663	13	'	'	``
cord-000248-zueoyesj	663	14	measure	measure	NN
cord-000248-zueoyesj	663	15	of	of	IN
cord-000248-zueoyesj	663	16	disorder	disorder	NN
cord-000248-zueoyesj	663	17	of	of	IN
cord-000248-zueoyesj	663	18	a	a	DT
cord-000248-zueoyesj	663	19	system	system	NN
cord-000248-zueoyesj	663	20	'	'	''
cord-000248-zueoyesj	663	21	'	'	''
cord-000248-zueoyesj	663	22	,	,	,
cord-000248-zueoyesj	663	23	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	663	24	,	,	,
cord-000248-zueoyesj	663	25	has	have	VBZ
cord-000248-zueoyesj	663	26	been	be	VBN
cord-000248-zueoyesj	663	27	observed	observe	VBN
cord-000248-zueoyesj	663	28	in	in	IN
cord-000248-zueoyesj	663	29	poorly	poorly	RB
cord-000248-zueoyesj	663	30	-	-	HYPH
cord-000248-zueoyesj	663	31	differentiated	differentiate	VBN
cord-000248-zueoyesj	663	32	prostate	prostate	NN
cord-000248-zueoyesj	663	33	cancer	cancer	NN
cord-000248-zueoyesj	663	34	cells	cell	NNS
cord-000248-zueoyesj	663	35	and	and	CC
cord-000248-zueoyesj	663	36	it	-PRON-	PRP
cord-000248-zueoyesj	663	37	is	be	VBZ
cord-000248-zueoyesj	663	38	often	often	RB
cord-000248-zueoyesj	663	39	associated	associate	VBN
cord-000248-zueoyesj	663	40	with	with	IN
cord-000248-zueoyesj	663	41	a	a	DT
cord-000248-zueoyesj	663	42	more	more	RBR
cord-000248-zueoyesj	663	43	agreessive	agreessive	JJ
cord-000248-zueoyesj	663	44	phenotype	phenotype	NN
cord-000248-zueoyesj	663	45	[	[	-LRB-
cord-000248-zueoyesj	663	46	602	602	CD
cord-000248-zueoyesj	663	47	,	,	,
cord-000248-zueoyesj	663	48	603	603	CD
cord-000248-zueoyesj	663	49	]	]	-RRB-
cord-000248-zueoyesj	663	50	,	,	,
cord-000248-zueoyesj	663	51	increased	increase	VBD
cord-000248-zueoyesj	663	52	PSA	PSA	NNP
cord-000248-zueoyesj	663	53	levels	level	NNS
cord-000248-zueoyesj	663	54	[	[	-LRB-
cord-000248-zueoyesj	663	55	604	604	CD
cord-000248-zueoyesj	663	56	,	,	,
cord-000248-zueoyesj	663	57	605	605	CD
cord-000248-zueoyesj	663	58	]	]	-RRB-
cord-000248-zueoyesj	663	59	,	,	,
cord-000248-zueoyesj	663	60	and	and	CC
cord-000248-zueoyesj	663	61	correlate	correlate	VB
cord-000248-zueoyesj	663	62	with	with	IN
cord-000248-zueoyesj	663	63	Gleason	Gleason	NNP
cord-000248-zueoyesj	663	64	score	score	NN
cord-000248-zueoyesj	663	65	[	[	-LRB-
cord-000248-zueoyesj	663	66	606	606	CD
cord-000248-zueoyesj	663	67	,	,	,
cord-000248-zueoyesj	663	68	607	607	CD
cord-000248-zueoyesj	663	69	,	,	,
cord-000248-zueoyesj	663	70	608	608	CD
cord-000248-zueoyesj	663	71	]	]	-RRB-
cord-000248-zueoyesj	663	72	.	.	.
cord-000248-zueoyesj	664	1	Gene	gene	NN
cord-000248-zueoyesj	664	2	fusions	fusion	NNS
cord-000248-zueoyesj	664	3	and	and	CC
cord-000248-zueoyesj	664	4	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	664	5	rearrangements	rearrangement	NNS
cord-000248-zueoyesj	664	6	are	be	VBP
cord-000248-zueoyesj	664	7	other	other	JJ
cord-000248-zueoyesj	664	8	source	source	NN
cord-000248-zueoyesj	664	9	of	of	IN
cord-000248-zueoyesj	664	10	increase	increase	NN
cord-000248-zueoyesj	664	11	in	in	IN
cord-000248-zueoyesj	664	12	the	the	DT
cord-000248-zueoyesj	664	13	'	'	''
cord-000248-zueoyesj	664	14	'	'	``
cord-000248-zueoyesj	664	15	disorder	disorder	NN
cord-000248-zueoyesj	664	16	'	'	''
cord-000248-zueoyesj	664	17	'	'	''
cord-000248-zueoyesj	664	18	of	of	IN
cord-000248-zueoyesj	664	19	the	the	DT
cord-000248-zueoyesj	664	20	genome	genome	NN
cord-000248-zueoyesj	664	21	organization	organization	NN
cord-000248-zueoyesj	664	22	and	and	CC
cord-000248-zueoyesj	664	23	they	-PRON-	PRP
cord-000248-zueoyesj	664	24	are	be	VBP
cord-000248-zueoyesj	664	25	increasingly	increasingly	RB
cord-000248-zueoyesj	664	26	being	be	VBG
cord-000248-zueoyesj	664	27	recognized	recognize	VBN
cord-000248-zueoyesj	664	28	as	as	IN
cord-000248-zueoyesj	664	29	a	a	DT
cord-000248-zueoyesj	664	30	major	major	JJ
cord-000248-zueoyesj	664	31	player	player	NN
cord-000248-zueoyesj	664	32	in	in	IN
cord-000248-zueoyesj	664	33	prostate	prostate	NN
cord-000248-zueoyesj	664	34	cancer	cancer	NN
cord-000248-zueoyesj	664	35	progression	progression	NN
cord-000248-zueoyesj	664	36	[	[	-LRB-
cord-000248-zueoyesj	664	37	609	609	CD
cord-000248-zueoyesj	664	38	]	]	-RRB-
cord-000248-zueoyesj	664	39	.	.	.
cord-000248-zueoyesj	665	1	The	the	DT
cord-000248-zueoyesj	665	2	increase	increase	NN
cord-000248-zueoyesj	665	3	in	in	IN
cord-000248-zueoyesj	665	4	'	'	''
cord-000248-zueoyesj	665	5	'	'	``
cord-000248-zueoyesj	665	6	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	665	7	complexity	complexity	NN
cord-000248-zueoyesj	665	8	'	'	''
cord-000248-zueoyesj	665	9	'	'	''
cord-000248-zueoyesj	665	10	and	and	CC
cord-000248-zueoyesj	665	11	'	'	''
cord-000248-zueoyesj	665	12	'	'	''
cord-000248-zueoyesj	665	13	extended	extended	JJ
cord-000248-zueoyesj	665	14	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	665	15	and	and	CC
cord-000248-zueoyesj	665	16	heteroploidy	heteroploidy	NNP
cord-000248-zueoyesj	665	17	'	'	''
cord-000248-zueoyesj	665	18	'	'	''
cord-000248-zueoyesj	665	19	may	may	MD
cord-000248-zueoyesj	665	20	be	be	VB
cord-000248-zueoyesj	665	21	already	already	RB
cord-000248-zueoyesj	665	22	enough	enough	JJ
cord-000248-zueoyesj	665	23	to	to	TO
cord-000248-zueoyesj	665	24	develop	develop	VB
cord-000248-zueoyesj	665	25	a	a	DT
cord-000248-zueoyesj	665	26	malignant	malignant	JJ
cord-000248-zueoyesj	665	27	melanoma	melanoma	NN
cord-000248-zueoyesj	665	28	phenotype	phenotype	NN
cord-000248-zueoyesj	665	29	,	,	,
cord-000248-zueoyesj	665	30	as	as	IN
cord-000248-zueoyesj	665	31	the	the	DT
cord-000248-zueoyesj	665	32	report	report	NN
cord-000248-zueoyesj	665	33	of	of	IN
cord-000248-zueoyesj	665	34	Gagos	Gagos	NNP
cord-000248-zueoyesj	665	35	et	et	NNP
cord-000248-zueoyesj	665	36	al	al	NNP
cord-000248-zueoyesj	665	37	.	.	.
cord-000248-zueoyesj	666	1	indicate	indicate	VBP
cord-000248-zueoyesj	666	2	[	[	-LRB-
cord-000248-zueoyesj	666	3	610	610	CD
cord-000248-zueoyesj	666	4	]	]	-RRB-
cord-000248-zueoyesj	666	5	.	.	.
cord-000248-zueoyesj	667	1	The	the	DT
cord-000248-zueoyesj	667	2	observed	observed	JJ
cord-000248-zueoyesj	667	3	finding	finding	NN
cord-000248-zueoyesj	667	4	of	of	IN
cord-000248-zueoyesj	667	5	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	667	6	in	in	IN
cord-000248-zueoyesj	667	7	melanoma	melanoma	NN
cord-000248-zueoyesj	667	8	(	(	-LRB-
cord-000248-zueoyesj	667	9	also	also	RB
cord-000248-zueoyesj	667	10	including	include	VBG
cord-000248-zueoyesj	667	11	uveal	uveal	JJ
cord-000248-zueoyesj	667	12	melanoma	melanoma	NN
cord-000248-zueoyesj	667	13	)	)	-RRB-
cord-000248-zueoyesj	667	14	is	be	VBZ
cord-000248-zueoyesj	667	15	also	also	RB
cord-000248-zueoyesj	667	16	increasingly	increasingly	RB
cord-000248-zueoyesj	667	17	important	important	JJ
cord-000248-zueoyesj	667	18	due	due	IN
cord-000248-zueoyesj	667	19	to	to	IN
cord-000248-zueoyesj	667	20	a	a	DT
cord-000248-zueoyesj	667	21	number	number	NN
cord-000248-zueoyesj	667	22	of	of	IN
cord-000248-zueoyesj	667	23	different	different	JJ
cord-000248-zueoyesj	667	24	independent	independent	JJ
cord-000248-zueoyesj	667	25	observations	observation	NNS
cord-000248-zueoyesj	667	26	[	[	-LRB-
cord-000248-zueoyesj	667	27	247	247	CD
cord-000248-zueoyesj	667	28	,	,	,
cord-000248-zueoyesj	667	29	611	611	CD
cord-000248-zueoyesj	667	30	,	,	,
cord-000248-zueoyesj	667	31	612	612	CD
cord-000248-zueoyesj	667	32	,	,	,
cord-000248-zueoyesj	667	33	613	613	CD
cord-000248-zueoyesj	667	34	,	,	,
cord-000248-zueoyesj	667	35	614	614	CD
cord-000248-zueoyesj	667	36	,	,	,
cord-000248-zueoyesj	667	37	615	615	CD
cord-000248-zueoyesj	667	38	,	,	,
cord-000248-zueoyesj	667	39	616	616	CD
cord-000248-zueoyesj	667	40	,	,	,
cord-000248-zueoyesj	667	41	617	617	CD
cord-000248-zueoyesj	667	42	,	,	,
cord-000248-zueoyesj	667	43	618	618	CD
cord-000248-zueoyesj	667	44	]	]	-RRB-
cord-000248-zueoyesj	667	45	.	.	.
cord-000248-zueoyesj	668	1	It	-PRON-	PRP
cord-000248-zueoyesj	668	2	is	be	VBZ
cord-000248-zueoyesj	668	3	in	in	IN
cord-000248-zueoyesj	668	4	this	this	DT
cord-000248-zueoyesj	668	5	context	context	NN
cord-000248-zueoyesj	668	6	that	that	IN
cord-000248-zueoyesj	668	7	the	the	DT
cord-000248-zueoyesj	668	8	word	word	NN
cord-000248-zueoyesj	668	9	'	'	``
cord-000248-zueoyesj	668	10	entropy	entropy	NN
cord-000248-zueoyesj	668	11	'	'	''
cord-000248-zueoyesj	668	12	has	have	VBZ
cord-000248-zueoyesj	668	13	been	be	VBN
cord-000248-zueoyesj	668	14	used	use	VBN
cord-000248-zueoyesj	668	15	.	.	.
cord-000248-zueoyesj	669	1	The	the	DT
cord-000248-zueoyesj	669	2	magnitude	magnitude	NN
cord-000248-zueoyesj	669	3	of	of	IN
cord-000248-zueoyesj	669	4	the	the	DT
cord-000248-zueoyesj	669	5	'	'	``
cord-000248-zueoyesj	669	6	'	'	``
cord-000248-zueoyesj	669	7	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	669	8	chaos	chaos	NN
cord-000248-zueoyesj	669	9	'	'	''
cord-000248-zueoyesj	669	10	'	'	''
cord-000248-zueoyesj	669	11	is	be	VBZ
cord-000248-zueoyesj	669	12	also	also	RB
cord-000248-zueoyesj	669	13	evident	evident	JJ
cord-000248-zueoyesj	669	14	from	from	IN
cord-000248-zueoyesj	669	15	comparative	comparative	JJ
cord-000248-zueoyesj	669	16	genomic	genomic	JJ
cord-000248-zueoyesj	669	17	hybridization	hybridization	NN
cord-000248-zueoyesj	669	18	(	(	-LRB-
cord-000248-zueoyesj	669	19	CGH	CGH	NNP
cord-000248-zueoyesj	669	20	)	)	-RRB-
cord-000248-zueoyesj	669	21	studies	study	NNS
cord-000248-zueoyesj	669	22	which	which	WDT
cord-000248-zueoyesj	669	23	show	show	VBP
cord-000248-zueoyesj	669	24	significant	significant	JJ
cord-000248-zueoyesj	669	25	variations	variation	NNS
cord-000248-zueoyesj	669	26	in	in	IN
cord-000248-zueoyesj	669	27	the	the	DT
cord-000248-zueoyesj	669	28	copy	copy	NN
cord-000248-zueoyesj	669	29	number	number	NN
cord-000248-zueoyesj	669	30	of	of	IN
cord-000248-zueoyesj	669	31	individual	individual	JJ
cord-000248-zueoyesj	669	32	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	669	33	segments	segment	NNS
cord-000248-zueoyesj	669	34	.	.	.
cord-000248-zueoyesj	669	35	'	'	''
cord-000248-zueoyesj	670	1	Chaos	chaos	NN
cord-000248-zueoyesj	670	2	'	'	''
cord-000248-zueoyesj	670	3	is	be	VBZ
cord-000248-zueoyesj	670	4	really	really	RB
cord-000248-zueoyesj	670	5	a	a	DT
cord-000248-zueoyesj	670	6	very	very	RB
cord-000248-zueoyesj	670	7	appropriate	appropriate	JJ
cord-000248-zueoyesj	670	8	word	word	NN
cord-000248-zueoyesj	670	9	to	to	TO
cord-000248-zueoyesj	670	10	describe	describe	VB
cord-000248-zueoyesj	670	11	what	what	WP
cord-000248-zueoyesj	670	12	we	-PRON-	PRP
cord-000248-zueoyesj	670	13	observe	observe	VBP
cord-000248-zueoyesj	670	14	from	from	IN
cord-000248-zueoyesj	670	15	CGH	CGH	NNP
cord-000248-zueoyesj	670	16	data	datum	NNS
cord-000248-zueoyesj	670	17	.	.	.
cord-000248-zueoyesj	671	1	The	the	DT
cord-000248-zueoyesj	671	2	genomic	genomic	JJ
cord-000248-zueoyesj	671	3	changes	change	NNS
cord-000248-zueoyesj	671	4	are	be	VBP
cord-000248-zueoyesj	671	5	not	not	RB
cord-000248-zueoyesj	671	6	distributed	distribute	VBN
cord-000248-zueoyesj	671	7	uniformly	uniformly	RB
cord-000248-zueoyesj	671	8	at	at	IN
cord-000248-zueoyesj	671	9	random	random	JJ
cord-000248-zueoyesj	671	10	.	.	.
cord-000248-zueoyesj	671	11	'	'	''
cord-000248-zueoyesj	672	1	Chaos	chaos	NN
cord-000248-zueoyesj	672	2	'	'	''
cord-000248-zueoyesj	672	3	has	have	VBZ
cord-000248-zueoyesj	672	4	been	be	VBN
cord-000248-zueoyesj	672	5	described	describe	VBN
cord-000248-zueoyesj	672	6	by	by	IN
cord-000248-zueoyesj	672	7	some	some	DT
cord-000248-zueoyesj	672	8	researchers	researcher	NNS
cord-000248-zueoyesj	672	9	as	as	IN
cord-000248-zueoyesj	672	10	'	'	''
cord-000248-zueoyesj	672	11	'	'	''
cord-000248-zueoyesj	672	12	a	a	DT
cord-000248-zueoyesj	672	13	kind	kind	NN
cord-000248-zueoyesj	672	14	of	of	IN
cord-000248-zueoyesj	672	15	order	order	NN
cord-000248-zueoyesj	672	16	without	without	IN
cord-000248-zueoyesj	672	17	any	any	DT
cord-000248-zueoyesj	672	18	periodicity	periodicity	NN
cord-000248-zueoyesj	672	19	'	'	''
cord-000248-zueoyesj	672	20	'	'	''
cord-000248-zueoyesj	672	21	.	.	.
cord-000248-zueoyesj	673	1	Some	some	DT
cord-000248-zueoyesj	673	2	common	common	JJ
cord-000248-zueoyesj	673	3	changes	change	NNS
cord-000248-zueoyesj	673	4	seem	seem	VBP
cord-000248-zueoyesj	673	5	to	to	TO
cord-000248-zueoyesj	673	6	consistently	consistently	RB
cord-000248-zueoyesj	673	7	appear	appear	VB
cord-000248-zueoyesj	673	8	in	in	IN
cord-000248-zueoyesj	673	9	several	several	JJ
cord-000248-zueoyesj	673	10	independently	independently	RB
cord-000248-zueoyesj	673	11	arising	arise	VBG
cord-000248-zueoyesj	673	12	tumours	tumour	NNS
cord-000248-zueoyesj	673	13	of	of	IN
cord-000248-zueoyesj	673	14	the	the	DT
cord-000248-zueoyesj	673	15	same	same	JJ
cord-000248-zueoyesj	673	16	type	type	NN
cord-000248-zueoyesj	673	17	,	,	,
cord-000248-zueoyesj	673	18	and	and	CC
cord-000248-zueoyesj	673	19	sometimes	sometimes	RB
cord-000248-zueoyesj	673	20	the	the	DT
cord-000248-zueoyesj	673	21	researchers	researcher	NNS
cord-000248-zueoyesj	673	22	suggest	suggest	VBP
cord-000248-zueoyesj	673	23	common	common	JJ
cord-000248-zueoyesj	673	24	links	link	NNS
cord-000248-zueoyesj	673	25	[	[	-LRB-
cord-000248-zueoyesj	673	26	619	619	CD
cord-000248-zueoyesj	673	27	]	]	-RRB-
cord-000248-zueoyesj	673	28	.	.	.
cord-000248-zueoyesj	674	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	674	2	work	work	NN
cord-000248-zueoyesj	674	3	has	have	VBZ
cord-000248-zueoyesj	674	4	addressed	address	VBN
cord-000248-zueoyesj	674	5	,	,	,
cord-000248-zueoyesj	674	6	in	in	IN
cord-000248-zueoyesj	674	7	part	part	NN
cord-000248-zueoyesj	674	8	,	,	,
cord-000248-zueoyesj	674	9	this	this	DT
cord-000248-zueoyesj	674	10	question	question	NN
cord-000248-zueoyesj	674	11	:	:	:
cord-000248-zueoyesj	674	12	''	''	''
cord-000248-zueoyesj	675	1	Can	Can	MD
cord-000248-zueoyesj	675	2	we	-PRON-	PRP
cord-000248-zueoyesj	675	3	quantify	quantify	VB
cord-000248-zueoyesj	675	4	the	the	DT
cord-000248-zueoyesj	675	5	chaos	chaos	NN
cord-000248-zueoyesj	675	6	observed	observe	VBN
cord-000248-zueoyesj	675	7	in	in	IN
cord-000248-zueoyesj	675	8	the	the	DT
cord-000248-zueoyesj	675	9	genome	genome	NN
cord-000248-zueoyesj	675	10	from	from	IN
cord-000248-zueoyesj	675	11	the	the	DT
cord-000248-zueoyesj	675	12	increasingly	increasingly	RB
cord-000248-zueoyesj	675	13	available	available	JJ
cord-000248-zueoyesj	675	14	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	675	15	data	datum	NNS
cord-000248-zueoyesj	675	16	and	and	CC
cord-000248-zueoyesj	675	17	relate	relate	VBP
cord-000248-zueoyesj	675	18	it	-PRON-	PRP
cord-000248-zueoyesj	675	19	to	to	TO
cord-000248-zueoyesj	675	20	tumour	tumour	VB
cord-000248-zueoyesj	675	21	progression	progression	NN
cord-000248-zueoyesj	675	22	?	?	.
cord-000248-zueoyesj	675	23	'	'	''
cord-000248-zueoyesj	675	24	'	'	''
cord-000248-zueoyesj	676	1	If	if	IN
cord-000248-zueoyesj	676	2	no	no	DT
cord-000248-zueoyesj	676	3	commonalities	commonality	NNS
cord-000248-zueoyesj	676	4	were	be	VBD
cord-000248-zueoyesj	676	5	observed	observe	VBN
cord-000248-zueoyesj	676	6	,	,	,
cord-000248-zueoyesj	676	7	we	-PRON-	PRP
cord-000248-zueoyesj	676	8	would	would	MD
cord-000248-zueoyesj	676	9	not	not	RB
cord-000248-zueoyesj	676	10	have	have	VB
cord-000248-zueoyesj	676	11	found	find	VBN
cord-000248-zueoyesj	676	12	interesting	interesting	JJ
cord-000248-zueoyesj	676	13	biomarkers	biomarker	NNS
cord-000248-zueoyesj	676	14	that	that	WDT
cord-000248-zueoyesj	676	15	seem	seem	VBP
cord-000248-zueoyesj	676	16	that	that	IN
cord-000248-zueoyesj	676	17	strongly	strongly	RB
cord-000248-zueoyesj	676	18	correlate	correlate	VB
cord-000248-zueoyesj	676	19	with	with	IN
cord-000248-zueoyesj	676	20	the	the	DT
cord-000248-zueoyesj	676	21	divergences	divergence	NNS
cord-000248-zueoyesj	676	22	from	from	IN
cord-000248-zueoyesj	676	23	normal	normal	JJ
cord-000248-zueoyesj	676	24	tissue	tissue	NN
cord-000248-zueoyesj	676	25	types	type	NNS
cord-000248-zueoyesj	676	26	.	.	.
cord-000248-zueoyesj	677	1	We	-PRON-	PRP
cord-000248-zueoyesj	677	2	know	know	VBP
cord-000248-zueoyesj	677	3	from	from	IN
cord-000248-zueoyesj	677	4	our	-PRON-	PRP$
cord-000248-zueoyesj	677	5	results	result	NNS
cord-000248-zueoyesj	677	6	that	that	IN
cord-000248-zueoyesj	677	7	these	these	DT
cord-000248-zueoyesj	677	8	commonalities	commonality	NNS
cord-000248-zueoyesj	677	9	do	do	VBP
cord-000248-zueoyesj	677	10	occur	occur	VB
cord-000248-zueoyesj	677	11	.	.	.
cord-000248-zueoyesj	678	1	We	-PRON-	PRP
cord-000248-zueoyesj	678	2	need	need	VBP
cord-000248-zueoyesj	678	3	to	to	TO
cord-000248-zueoyesj	678	4	go	go	VB
cord-000248-zueoyesj	678	5	back	back	RB
cord-000248-zueoyesj	678	6	to	to	IN
cord-000248-zueoyesj	678	7	basics	basic	NNS
cord-000248-zueoyesj	678	8	to	to	TO
cord-000248-zueoyesj	678	9	explain	explain	VB
cord-000248-zueoyesj	678	10	these	these	DT
cord-000248-zueoyesj	678	11	evolving	evolve	VBG
cord-000248-zueoyesj	678	12	concepts	concept	NNS
cord-000248-zueoyesj	678	13	and	and	CC
cord-000248-zueoyesj	678	14	resolve	resolve	VB
cord-000248-zueoyesj	678	15	this	this	DT
cord-000248-zueoyesj	678	16	apparent	apparent	JJ
cord-000248-zueoyesj	678	17	paradox	paradox	NN
cord-000248-zueoyesj	678	18	.	.	.
cord-000248-zueoyesj	679	1	The	the	DT
cord-000248-zueoyesj	679	2	phrase	phrase	NN
cord-000248-zueoyesj	679	3	'	'	''
cord-000248-zueoyesj	679	4	'	'	``
cord-000248-zueoyesj	679	5	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	679	6	entropy	entropy	NNP
cord-000248-zueoyesj	679	7	'	'	''
cord-000248-zueoyesj	679	8	'	'	''
cord-000248-zueoyesj	679	9	has	have	VBZ
cord-000248-zueoyesj	679	10	been	be	VBN
cord-000248-zueoyesj	679	11	used	use	VBN
cord-000248-zueoyesj	679	12	in	in	IN
cord-000248-zueoyesj	679	13	the	the	DT
cord-000248-zueoyesj	679	14	past	past	NN
cord-000248-zueoyesj	679	15	to	to	TO
cord-000248-zueoyesj	679	16	define	define	VB
cord-000248-zueoyesj	679	17	what	what	WP
cord-000248-zueoyesj	679	18	is	be	VBZ
cord-000248-zueoyesj	679	19	actually	actually	RB
cord-000248-zueoyesj	679	20	a	a	DT
cord-000248-zueoyesj	679	21	divergence	divergence	NN
cord-000248-zueoyesj	679	22	from	from	IN
cord-000248-zueoyesj	679	23	the	the	DT
cord-000248-zueoyesj	679	24	normal	normal	JJ
cord-000248-zueoyesj	679	25	chromosome	chromosome	NN
cord-000248-zueoyesj	679	26	structure	structure	NN
cord-000248-zueoyesj	679	27	and	and	CC
cord-000248-zueoyesj	679	28	it	-PRON-	PRP
cord-000248-zueoyesj	679	29	genomic	genomic	JJ
cord-000248-zueoyesj	679	30	organization	organization	NN
cord-000248-zueoyesj	679	31	.	.	.
cord-000248-zueoyesj	680	1	This	this	DT
cord-000248-zueoyesj	680	2	denomination	denomination	NN
cord-000248-zueoyesj	680	3	has	have	VBZ
cord-000248-zueoyesj	680	4	also	also	RB
cord-000248-zueoyesj	680	5	been	be	VBN
cord-000248-zueoyesj	680	6	employed	employ	VBN
cord-000248-zueoyesj	680	7	by	by	IN
cord-000248-zueoyesj	680	8	several	several	JJ
cord-000248-zueoyesj	680	9	authors	author	NNS
cord-000248-zueoyesj	680	10	,	,	,
cord-000248-zueoyesj	680	11	notably	notably	RB
cord-000248-zueoyesj	680	12	[	[	-LRB-
cord-000248-zueoyesj	680	13	601	601	CD
cord-000248-zueoyesj	680	14	]	]	-RRB-
cord-000248-zueoyesj	680	15	,	,	,
cord-000248-zueoyesj	680	16	but	but	CC
cord-000248-zueoyesj	680	17	it	-PRON-	PRP
cord-000248-zueoyesj	680	18	has	have	VBZ
cord-000248-zueoyesj	680	19	also	also	RB
cord-000248-zueoyesj	680	20	been	be	VBN
cord-000248-zueoyesj	680	21	used	use	VBN
cord-000248-zueoyesj	680	22	in	in	IN
cord-000248-zueoyesj	680	23	at	at	RB
cord-000248-zueoyesj	680	24	least	least	RBS
cord-000248-zueoyesj	680	25	two	two	CD
cord-000248-zueoyesj	680	26	other	other	JJ
cord-000248-zueoyesj	680	27	publications	publication	NNS
cord-000248-zueoyesj	680	28	[	[	-LRB-
cord-000248-zueoyesj	680	29	620	620	CD
cord-000248-zueoyesj	680	30	,	,	,
cord-000248-zueoyesj	680	31	621	621	CD
cord-000248-zueoyesj	680	32	]	]	-RRB-
cord-000248-zueoyesj	680	33	.	.	.
cord-000248-zueoyesj	681	1	These	these	DT
cord-000248-zueoyesj	681	2	works	work	NNS
cord-000248-zueoyesj	681	3	have	have	VBP
cord-000248-zueoyesj	681	4	in	in	IN
cord-000248-zueoyesj	681	5	common	common	JJ
cord-000248-zueoyesj	681	6	the	the	DT
cord-000248-zueoyesj	681	7	use	use	NN
cord-000248-zueoyesj	681	8	of	of	IN
cord-000248-zueoyesj	681	9	this	this	DT
cord-000248-zueoyesj	681	10	term	term	NN
cord-000248-zueoyesj	681	11	to	to	TO
cord-000248-zueoyesj	681	12	refer	refer	VB
cord-000248-zueoyesj	681	13	to	to	IN
cord-000248-zueoyesj	681	14	a	a	DT
cord-000248-zueoyesj	681	15	'	'	''
cord-000248-zueoyesj	681	16	'	'	``
cord-000248-zueoyesj	681	17	disorder	disorder	NN
cord-000248-zueoyesj	681	18	'	'	''
cord-000248-zueoyesj	681	19	'	'	''
cord-000248-zueoyesj	681	20	,	,	,
cord-000248-zueoyesj	681	21	fuelled	fuel	VBN
cord-000248-zueoyesj	681	22	by	by	IN
cord-000248-zueoyesj	681	23	the	the	DT
cord-000248-zueoyesj	681	24	undergraduate	undergraduate	JJ
cord-000248-zueoyesj	681	25	textbooks	textbook	NNS
cord-000248-zueoyesj	681	26	indoctrination	indoctrination	NN
cord-000248-zueoyesj	681	27	of	of	IN
cord-000248-zueoyesj	681	28	associating	associate	VBG
cord-000248-zueoyesj	681	29	increase	increase	NN
cord-000248-zueoyesj	681	30	of	of	IN
cord-000248-zueoyesj	681	31	entropy	entropy	NN
cord-000248-zueoyesj	681	32	in	in	IN
cord-000248-zueoyesj	681	33	natural	natural	JJ
cord-000248-zueoyesj	681	34	spontaneous	spontaneous	JJ
cord-000248-zueoyesj	681	35	processes	process	NNS
cord-000248-zueoyesj	681	36	with	with	IN
cord-000248-zueoyesj	681	37	the	the	DT
cord-000248-zueoyesj	681	38	increase	increase	NN
cord-000248-zueoyesj	681	39	of	of	IN
cord-000248-zueoyesj	681	40	'	'	''
cord-000248-zueoyesj	681	41	'	'	''
cord-000248-zueoyesj	681	42	observed	observed	JJ
cord-000248-zueoyesj	681	43	disorder	disorder	NN
cord-000248-zueoyesj	681	44	'	'	''
cord-000248-zueoyesj	681	45	'	'	''
cord-000248-zueoyesj	681	46	in	in	IN
cord-000248-zueoyesj	681	47	the	the	DT
cord-000248-zueoyesj	681	48	system	system	NN
cord-000248-zueoyesj	681	49	.	.	.
cord-000248-zueoyesj	682	1	We	-PRON-	PRP
cord-000248-zueoyesj	682	2	propose	propose	VBP
cord-000248-zueoyesj	682	3	that	that	IN
cord-000248-zueoyesj	682	4	the	the	DT
cord-000248-zueoyesj	682	5	use	use	NN
cord-000248-zueoyesj	682	6	of	of	IN
cord-000248-zueoyesj	682	7	a	a	DT
cord-000248-zueoyesj	682	8	natural	natural	JJ
cord-000248-zueoyesj	682	9	measure	measure	NN
cord-000248-zueoyesj	682	10	of	of	IN
cord-000248-zueoyesj	682	11	divergence	divergence	NN
cord-000248-zueoyesj	682	12	,	,	,
cord-000248-zueoyesj	682	13	the	the	DT
cord-000248-zueoyesj	682	14	Jensen	Jensen	NNP
cord-000248-zueoyesj	682	15	-	-	HYPH
cord-000248-zueoyesj	682	16	Shannon	Shannon	NNP
cord-000248-zueoyesj	682	17	divergence	divergence	NN
cord-000248-zueoyesj	682	18	,	,	,
cord-000248-zueoyesj	682	19	could	could	MD
cord-000248-zueoyesj	682	20	not	not	RB
cord-000248-zueoyesj	682	21	only	only	RB
cord-000248-zueoyesj	682	22	be	be	VB
cord-000248-zueoyesj	682	23	a	a	DT
cord-000248-zueoyesj	682	24	more	more	RBR
cord-000248-zueoyesj	682	25	formal	formal	JJ
cord-000248-zueoyesj	682	26	,	,	,
cord-000248-zueoyesj	682	27	but	but	CC
cord-000248-zueoyesj	682	28	also	also	RB
cord-000248-zueoyesj	682	29	more	more	RBR
cord-000248-zueoyesj	682	30	appropriate	appropriate	JJ
cord-000248-zueoyesj	682	31	modelling	modelling	NN
cord-000248-zueoyesj	682	32	approach	approach	NN
cord-000248-zueoyesj	682	33	.	.	.
cord-000248-zueoyesj	683	1	As	as	IN
cord-000248-zueoyesj	683	2	such	such	JJ
cord-000248-zueoyesj	683	3	,	,	,
cord-000248-zueoyesj	683	4	we	-PRON-	PRP
cord-000248-zueoyesj	683	5	propose	propose	VBP
cord-000248-zueoyesj	683	6	to	to	TO
cord-000248-zueoyesj	683	7	introduce	introduce	VB
cord-000248-zueoyesj	683	8	the	the	DT
cord-000248-zueoyesj	683	9	term	term	NN
cord-000248-zueoyesj	683	10	'	'	``
cord-000248-zueoyesj	683	11	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	683	12	divergence	divergence	NNP
cord-000248-zueoyesj	683	13	'	'	''
cord-000248-zueoyesj	683	14	or	or	CC
cord-000248-zueoyesj	683	15	'	'	``
cord-000248-zueoyesj	683	16	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	683	17	Jensen	Jensen	NNP
cord-000248-zueoyesj	683	18	-	-	HYPH
cord-000248-zueoyesj	683	19	Shannon	Shannon	NNP
cord-000248-zueoyesj	683	20	divergence	divergence	NN
cord-000248-zueoyesj	683	21	'	'	''
cord-000248-zueoyesj	683	22	to	to	TO
cord-000248-zueoyesj	683	23	replace	replace	VB
cord-000248-zueoyesj	683	24	this	this	DT
cord-000248-zueoyesj	683	25	concept	concept	NN
cord-000248-zueoyesj	683	26	and	and	CC
cord-000248-zueoyesj	683	27	to	to	TO
cord-000248-zueoyesj	683	28	avoid	avoid	VB
cord-000248-zueoyesj	683	29	a	a	DT
cord-000248-zueoyesj	683	30	subjective	subjective	JJ
cord-000248-zueoyesj	683	31	approach	approach	NN
cord-000248-zueoyesj	683	32	.	.	.
cord-000248-zueoyesj	684	1	Why	why	WRB
cord-000248-zueoyesj	684	2	is	be	VBZ
cord-000248-zueoyesj	684	3	it	-PRON-	PRP
cord-000248-zueoyesj	684	4	the	the	DT
cord-000248-zueoyesj	684	5	case	case	NN
cord-000248-zueoyesj	684	6	that	that	IN
cord-000248-zueoyesj	684	7	we	-PRON-	PRP
cord-000248-zueoyesj	684	8	observe	observe	VBP
cord-000248-zueoyesj	684	9	the	the	DT
cord-000248-zueoyesj	684	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	684	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	684	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	684	13	of	of	IN
cord-000248-zueoyesj	684	14	the	the	DT
cord-000248-zueoyesj	684	15	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	684	16	profile	profile	NN
cord-000248-zueoyesj	684	17	decreasing	decrease	VBG
cord-000248-zueoyesj	684	18	with	with	IN
cord-000248-zueoyesj	684	19	cancer	cancer	NN
cord-000248-zueoyesj	684	20	progression	progression	NN
cord-000248-zueoyesj	684	21	when	when	WRB
cord-000248-zueoyesj	684	22	intuitively	intuitively	RB
cord-000248-zueoyesj	684	23	our	-PRON-	PRP$
cord-000248-zueoyesj	684	24	average	average	JJ
cord-000248-zueoyesj	684	25	expected	expect	VBN
cord-000248-zueoyesj	684	26	surprisal	surprisal	NNP
cord-000248-zueoyesj	684	27	(	(	-LRB-
cord-000248-zueoyesj	684	28	Shannon	Shannon	NNP
cord-000248-zueoyesj	684	29	Entropy	Entropy	NNP
cord-000248-zueoyesj	684	30	)	)	-RRB-
cord-000248-zueoyesj	684	31	should	should	MD
cord-000248-zueoyesj	684	32	increase	increase	VB
cord-000248-zueoyesj	684	33	with	with	IN
cord-000248-zueoyesj	684	34	progression	progression	NN
cord-000248-zueoyesj	684	35	?	?	.
cord-000248-zueoyesj	685	1	Arieh	Arieh	NNP
cord-000248-zueoyesj	685	2	Ben	Ben	NNP
cord-000248-zueoyesj	685	3	-	-	HYPH
cord-000248-zueoyesj	685	4	Naim	Naim	NNP
cord-000248-zueoyesj	685	5	in	in	IN
cord-000248-zueoyesj	685	6	his	-PRON-	PRP$
cord-000248-zueoyesj	685	7	recent	recent	JJ
cord-000248-zueoyesj	685	8	book	book	NN
cord-000248-zueoyesj	685	9	'	'	''
cord-000248-zueoyesj	685	10	'	'	''
cord-000248-zueoyesj	685	11	A	a	DT
cord-000248-zueoyesj	685	12	farewell	farewell	NN
cord-000248-zueoyesj	685	13	to	to	IN
cord-000248-zueoyesj	685	14	Entropy	entropy	NN
cord-000248-zueoyesj	685	15	:	:	:
cord-000248-zueoyesj	685	16	Statistical	Statistical	NNP
cord-000248-zueoyesj	685	17	Thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	685	18	based	base	VBN
cord-000248-zueoyesj	685	19	on	on	IN
cord-000248-zueoyesj	685	20	Information	Information	NNP
cord-000248-zueoyesj	685	21	'	'	''
cord-000248-zueoyesj	685	22	'	'	''
cord-000248-zueoyesj	685	23	[	[	-LRB-
cord-000248-zueoyesj	685	24	622	622	CD
cord-000248-zueoyesj	685	25	]	]	-RRB-
cord-000248-zueoyesj	686	1	comments:''It	comments:''It	NNP
cord-000248-zueoyesj	686	2	is	be	VBZ
cord-000248-zueoyesj	686	3	interesting	interesting	JJ
cord-000248-zueoyesj	686	4	to	to	TO
cord-000248-zueoyesj	686	5	note	note	VB
cord-000248-zueoyesj	686	6	that	that	IN
cord-000248-zueoyesj	686	7	Landsberg	Landsberg	NNP
cord-000248-zueoyesj	686	8	(	(	-LRB-
cord-000248-zueoyesj	686	9	1978	1978	CD
cord-000248-zueoyesj	686	10	)	)	-RRB-
cord-000248-zueoyesj	686	11	not	not	RB
cord-000248-zueoyesj	686	12	only	only	RB
cord-000248-zueoyesj	686	13	contended	contend	VBD
cord-000248-zueoyesj	686	14	that	that	IN
cord-000248-zueoyesj	686	15	disorder	disorder	NN
cord-000248-zueoyesj	686	16	is	be	VBZ
cord-000248-zueoyesj	686	17	an	an	DT
cord-000248-zueoyesj	686	18	ill	ill	RB
cord-000248-zueoyesj	686	19	-	-	HYPH
cord-000248-zueoyesj	686	20	defined	define	VBN
cord-000248-zueoyesj	686	21	concept	concept	NN
cord-000248-zueoyesj	686	22	,	,	,
cord-000248-zueoyesj	686	23	but	but	CC
cord-000248-zueoyesj	686	24	actually	actually	RB
cord-000248-zueoyesj	686	25	made	make	VBD
cord-000248-zueoyesj	686	26	the	the	DT
cord-000248-zueoyesj	686	27	assertion	assertion	NN
cord-000248-zueoyesj	686	28	that	that	IN
cord-000248-zueoyesj	686	29	'	'	``
cord-000248-zueoyesj	686	30	it	-PRON-	PRP
cord-000248-zueoyesj	686	31	is	be	VBZ
cord-000248-zueoyesj	686	32	reasonable	reasonable	JJ
cord-000248-zueoyesj	686	33	to	to	TO
cord-000248-zueoyesj	686	34	expect	expect	VB
cord-000248-zueoyesj	686	35	'	'	``
cord-000248-zueoyesj	686	36	disorder	disorder	NN
cord-000248-zueoyesj	686	37	'	'	''
cord-000248-zueoyesj	686	38	to	to	TO
cord-000248-zueoyesj	686	39	be	be	VB
cord-000248-zueoyesj	686	40	an	an	DT
cord-000248-zueoyesj	686	41	intensive	intensive	JJ
cord-000248-zueoyesj	686	42	variable	variable	NN
cord-000248-zueoyesj	686	43	'	'	''
cord-000248-zueoyesj	686	44	'	'	''
cord-000248-zueoyesj	686	45	'	'	''
cord-000248-zueoyesj	686	46	.	.	.
cord-000248-zueoyesj	687	1	Ben	Ben	NNP
cord-000248-zueoyesj	687	2	-	-	HYPH
cord-000248-zueoyesj	687	3	Naim	Naim	NNP
cord-000248-zueoyesj	687	4	also	also	RB
cord-000248-zueoyesj	687	5	states	state	VBZ
cord-000248-zueoyesj	687	6	:	:	:
cord-000248-zueoyesj	687	7	''	''	''
cord-000248-zueoyesj	688	1	In	in	IN
cord-000248-zueoyesj	688	2	my	-PRON-	PRP$
cord-000248-zueoyesj	688	3	view	view	NN
cord-000248-zueoyesj	688	4	,	,	,
cord-000248-zueoyesj	688	5	it	-PRON-	PRP
cord-000248-zueoyesj	688	6	does	do	VBZ
cord-000248-zueoyesj	688	7	not	not	RB
cord-000248-zueoyesj	688	8	make	make	VB
cord-000248-zueoyesj	688	9	any	any	DT
cord-000248-zueoyesj	688	10	difference	difference	NN
cord-000248-zueoyesj	688	11	if	if	IN
cord-000248-zueoyesj	688	12	you	-PRON-	PRP
cord-000248-zueoyesj	688	13	refer	refer	VBP
cord-000248-zueoyesj	688	14	to	to	IN
cord-000248-zueoyesj	688	15	information	information	NN
cord-000248-zueoyesj	688	16	or	or	CC
cord-000248-zueoyesj	688	17	to	to	IN
cord-000248-zueoyesj	688	18	disorder	disorder	NN
cord-000248-zueoyesj	688	19	,	,	,
cord-000248-zueoyesj	688	20	as	as	IN
cord-000248-zueoyesj	688	21	subjective	subjective	JJ
cord-000248-zueoyesj	688	22	or	or	CC
cord-000248-zueoyesj	688	23	objective	objective	JJ
cord-000248-zueoyesj	688	24	.	.	.
cord-000248-zueoyesj	689	1	What	what	WP
cord-000248-zueoyesj	689	2	matters	matter	VBZ
cord-000248-zueoyesj	689	3	is	be	VBZ
cord-000248-zueoyesj	689	4	that	that	DT
cord-000248-zueoyesj	689	5	order	order	NN
cord-000248-zueoyesj	689	6	and	and	CC
cord-000248-zueoyesj	689	7	disorder	disorder	NN
cord-000248-zueoyesj	689	8	are	be	VBP
cord-000248-zueoyesj	689	9	not	not	RB
cord-000248-zueoyesj	689	10	well	well	RB
cord-000248-zueoyesj	689	11	-	-	HYPH
cord-000248-zueoyesj	689	12	defined	define	VBN
cord-000248-zueoyesj	689	13	scientific	scientific	JJ
cord-000248-zueoyesj	689	14	concepts	concept	NNS
cord-000248-zueoyesj	689	15	.	.	.
cord-000248-zueoyesj	690	1	On	on	IN
cord-000248-zueoyesj	690	2	the	the	DT
cord-000248-zueoyesj	690	3	other	other	JJ
cord-000248-zueoyesj	690	4	hand	hand	NN
cord-000248-zueoyesj	690	5	,	,	,
cord-000248-zueoyesj	690	6	information	information	NN
cord-000248-zueoyesj	690	7	is	be	VBZ
cord-000248-zueoyesj	690	8	a	a	DT
cord-000248-zueoyesj	690	9	well	well	RB
cord-000248-zueoyesj	690	10	-	-	HYPH
cord-000248-zueoyesj	690	11	defined	define	VBN
cord-000248-zueoyesj	690	12	scientific	scientific	JJ
cord-000248-zueoyesj	690	13	quantity	quantity	NN
cord-000248-zueoyesj	690	14	,	,	,
cord-000248-zueoyesj	690	15	as	as	RB
cord-000248-zueoyesj	690	16	much	much	RB
cord-000248-zueoyesj	690	17	as	as	IN
cord-000248-zueoyesj	690	18	a	a	DT
cord-000248-zueoyesj	690	19	point	point	NN
cord-000248-zueoyesj	690	20	or	or	CC
cord-000248-zueoyesj	690	21	a	a	DT
cord-000248-zueoyesj	690	22	line	line	NN
cord-000248-zueoyesj	690	23	are	be	VBP
cord-000248-zueoyesj	690	24	scientific	scientific	JJ
cord-000248-zueoyesj	690	25	in	in	IN
cord-000248-zueoyesj	690	26	geometry	geometry	NN
cord-000248-zueoyesj	690	27	,	,	,
cord-000248-zueoyesj	690	28	or	or	CC
cord-000248-zueoyesj	690	29	mass	mass	NN
cord-000248-zueoyesj	690	30	or	or	CC
cord-000248-zueoyesj	690	31	charge	charge	NN
cord-000248-zueoyesj	690	32	of	of	IN
cord-000248-zueoyesj	690	33	a	a	DT
cord-000248-zueoyesj	690	34	particle	particle	NN
cord-000248-zueoyesj	690	35	are	be	VBP
cord-000248-zueoyesj	690	36	scientific	scientific	JJ
cord-000248-zueoyesj	690	37	in	in	IN
cord-000248-zueoyesj	690	38	physics	physics	NN
cord-000248-zueoyesj	690	39	.	.	.
cord-000248-zueoyesj	690	40	'	'	''
cord-000248-zueoyesj	690	41	'	'	''
cord-000248-zueoyesj	691	1	However	however	RB
cord-000248-zueoyesj	691	2	,	,	,
cord-000248-zueoyesj	691	3	in	in	IN
cord-000248-zueoyesj	691	4	a	a	DT
cord-000248-zueoyesj	691	5	manuscript	manuscript	NN
cord-000248-zueoyesj	691	6	entitled	entitle	VBN
cord-000248-zueoyesj	691	7	'	'	``
cord-000248-zueoyesj	691	8	'	'	``
cord-000248-zueoyesj	691	9	Can	Can	MD
cord-000248-zueoyesj	691	10	Entropy	entropy	VB
cord-000248-zueoyesj	691	11	and	and	CC
cord-000248-zueoyesj	691	12	'	'	``
cord-000248-zueoyesj	691	13	order	order	NN
cord-000248-zueoyesj	691	14	'	'	''
cord-000248-zueoyesj	691	15	increase	increase	NN
cord-000248-zueoyesj	691	16	together	together	RB
cord-000248-zueoyesj	691	17	?	?	.
cord-000248-zueoyesj	691	18	''	''	''
cord-000248-zueoyesj	692	1	Landberg	Landberg	NNP
cord-000248-zueoyesj	692	2	defines	define	VBZ
cord-000248-zueoyesj	692	3	(	(	-LRB-
cord-000248-zueoyesj	692	4	in	in	IN
cord-000248-zueoyesj	692	5	an	an	DT
cord-000248-zueoyesj	692	6	attempt	attempt	NN
cord-000248-zueoyesj	692	7	to	to	TO
cord-000248-zueoyesj	692	8	decouple	decouple	VB
cord-000248-zueoyesj	692	9	the	the	DT
cord-000248-zueoyesj	692	10	notions	notion	NNS
cord-000248-zueoyesj	692	11	of	of	IN
cord-000248-zueoyesj	692	12	order	order	NN
cord-000248-zueoyesj	692	13	and	and	CC
cord-000248-zueoyesj	692	14	entropy	entropy	NN
cord-000248-zueoyesj	692	15	)	)	-RRB-
cord-000248-zueoyesj	692	16	,	,	,
cord-000248-zueoyesj	692	17	for	for	IN
cord-000248-zueoyesj	692	18	a	a	DT
cord-000248-zueoyesj	692	19	thermodynamical	thermodynamical	JJ
cord-000248-zueoyesj	692	20	system	system	NN
cord-000248-zueoyesj	692	21	that	that	WDT
cord-000248-zueoyesj	692	22	can	can	MD
cord-000248-zueoyesj	692	23	be	be	VB
cord-000248-zueoyesj	692	24	on	on	IN
cord-000248-zueoyesj	692	25	N	n	CD
cord-000248-zueoyesj	692	26	states	state	VBZ
cord-000248-zueoyesj	692	27	the	the	DT
cord-000248-zueoyesj	692	28	'	'	``
cord-000248-zueoyesj	692	29	disorder	disorder	NN
cord-000248-zueoyesj	692	30	'	'	''
cord-000248-zueoyesj	692	31	D(N	d(n	NN
cord-000248-zueoyesj	692	32	)	)	-RRB-
cord-000248-zueoyesj	692	33	to	to	TO
cord-000248-zueoyesj	692	34	be	be	VB
cord-000248-zueoyesj	692	35	the	the	DT
cord-000248-zueoyesj	692	36	Normalized	Normalized	NNP
cord-000248-zueoyesj	692	37	Entropy	Entropy	NNP
cord-000248-zueoyesj	692	38	(	(	-LRB-
cord-000248-zueoyesj	692	39	which	which	WDT
cord-000248-zueoyesj	692	40	is	be	VBZ
cord-000248-zueoyesj	692	41	a	a	DT
cord-000248-zueoyesj	692	42	function	function	NN
cord-000248-zueoyesj	692	43	of	of	IN
cord-000248-zueoyesj	692	44	N	n	NN
cord-000248-zueoyesj	692	45	)	)	-RRB-
cord-000248-zueoyesj	692	46	divided	divide	VBN
cord-000248-zueoyesj	692	47	by	by	IN
cord-000248-zueoyesj	692	48	Boltzmann	Boltzmann	NNP
cord-000248-zueoyesj	692	49	's	's	POS
cord-000248-zueoyesj	692	50	constant	constant	JJ
cord-000248-zueoyesj	692	51	[	[	-LRB-
cord-000248-zueoyesj	692	52	623	623	CD
cord-000248-zueoyesj	692	53	]	]	-RRB-
cord-000248-zueoyesj	692	54	.	.	.
cord-000248-zueoyesj	692	55	'	'	''
cord-000248-zueoyesj	693	1	Disorder	disorder	NN
cord-000248-zueoyesj	693	2	'	'	''
cord-000248-zueoyesj	693	3	then	then	RB
cord-000248-zueoyesj	693	4	is	be	VBZ
cord-000248-zueoyesj	693	5	an	an	DT
cord-000248-zueoyesj	693	6	intensive	intensive	JJ
cord-000248-zueoyesj	693	7	magnitude	magnitude	NN
cord-000248-zueoyesj	693	8	bounded	bound	VBN
cord-000248-zueoyesj	693	9	by	by	IN
cord-000248-zueoyesj	693	10	0	0	CD
cord-000248-zueoyesj	693	11	and	and	CC
cord-000248-zueoyesj	693	12	1	1	CD
cord-000248-zueoyesj	693	13	,	,	,
cord-000248-zueoyesj	693	14	and	and	CC
cord-000248-zueoyesj	693	15	'	'	``
cord-000248-zueoyesj	693	16	order	order	NN
cord-000248-zueoyesj	693	17	'	'	''
cord-000248-zueoyesj	693	18	is	be	VBZ
cord-000248-zueoyesj	693	19	defined	define	VBN
cord-000248-zueoyesj	693	20	as	as	IN
cord-000248-zueoyesj	693	21	1-D(N	1-d(n	CD
cord-000248-zueoyesj	693	22	)	)	-RRB-
cord-000248-zueoyesj	693	23	.	.	.
cord-000248-zueoyesj	694	1	While	while	IN
cord-000248-zueoyesj	694	2	Landberg	Landberg	NNP
cord-000248-zueoyesj	694	3	's	's	POS
cord-000248-zueoyesj	694	4	decoupling	decouple	VBG
cord-000248-zueoyesj	694	5	argument	argument	NN
cord-000248-zueoyesj	694	6	between	between	IN
cord-000248-zueoyesj	694	7	order	order	NN
cord-000248-zueoyesj	694	8	and	and	CC
cord-000248-zueoyesj	694	9	entropy	entropy	NN
cord-000248-zueoyesj	694	10	[	[	-LRB-
cord-000248-zueoyesj	694	11	623	623	CD
cord-000248-zueoyesj	694	12	]	]	-RRB-
cord-000248-zueoyesj	694	13	may	may	MD
cord-000248-zueoyesj	694	14	still	still	RB
cord-000248-zueoyesj	694	15	be	be	VB
cord-000248-zueoyesj	694	16	controversial	controversial	JJ
cord-000248-zueoyesj	694	17	in	in	IN
cord-000248-zueoyesj	694	18	Physics	Physics	NNP
cord-000248-zueoyesj	694	19	,	,	,
cord-000248-zueoyesj	694	20	the	the	DT
cord-000248-zueoyesj	694	21	question	question	NN
cord-000248-zueoyesj	694	22	is	be	VBZ
cord-000248-zueoyesj	694	23	pertinent	pertinent	JJ
cord-000248-zueoyesj	694	24	for	for	IN
cord-000248-zueoyesj	694	25	our	-PRON-	PRP$
cord-000248-zueoyesj	694	26	apparent	apparent	JJ
cord-000248-zueoyesj	694	27	paradox	paradox	NN
cord-000248-zueoyesj	694	28	(	(	-LRB-
cord-000248-zueoyesj	694	29	the	the	DT
cord-000248-zueoyesj	694	30	question	question	NN
cord-000248-zueoyesj	694	31	that	that	WDT
cord-000248-zueoyesj	694	32	motivates	motivate	VBZ
cord-000248-zueoyesj	694	33	this	this	DT
cord-000248-zueoyesj	694	34	subsection	subsection	NN
cord-000248-zueoyesj	694	35	)	)	-RRB-
cord-000248-zueoyesj	694	36	.	.	.
cord-000248-zueoyesj	695	1	Borrowing	borrow	VBG
cord-000248-zueoyesj	695	2	from	from	IN
cord-000248-zueoyesj	695	3	the	the	DT
cord-000248-zueoyesj	695	4	title	title	NN
cord-000248-zueoyesj	695	5	of	of	IN
cord-000248-zueoyesj	695	6	his	-PRON-	PRP$
cord-000248-zueoyesj	695	7	paper	paper	NN
cord-000248-zueoyesj	695	8	we	-PRON-	PRP
cord-000248-zueoyesj	695	9	could	could	MD
cord-000248-zueoyesj	695	10	now	now	RB
cord-000248-zueoyesj	695	11	state	state	VB
cord-000248-zueoyesj	695	12	the	the	DT
cord-000248-zueoyesj	695	13	central	central	JJ
cord-000248-zueoyesj	695	14	question	question	NN
cord-000248-zueoyesj	695	15	as	as	IN
cord-000248-zueoyesj	695	16	''	''	''
cord-000248-zueoyesj	696	1	Can	Can	MD
cord-000248-zueoyesj	696	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	696	3	Entropy	Entropy	NNP
cord-000248-zueoyesj	696	4	increase	increase	VB
cord-000248-zueoyesj	696	5	while	while	IN
cord-000248-zueoyesj	696	6	the	the	DT
cord-000248-zueoyesj	696	7	Normalized	Normalized	NNP
cord-000248-zueoyesj	696	8	Shannon	Shannon	NNP
cord-000248-zueoyesj	696	9	Entropy	Entropy	NNP
cord-000248-zueoyesj	696	10	decrease	decrease	NN
cord-000248-zueoyesj	696	11	?	?	.
cord-000248-zueoyesj	696	12	'	'	''
cord-000248-zueoyesj	696	13	'	'	''
cord-000248-zueoyesj	697	1	The	the	DT
cord-000248-zueoyesj	697	2	solution	solution	NN
cord-000248-zueoyesj	697	3	of	of	IN
cord-000248-zueoyesj	697	4	this	this	DT
cord-000248-zueoyesj	697	5	apparent	apparent	JJ
cord-000248-zueoyesj	697	6	paradox	paradox	NN
cord-000248-zueoyesj	697	7	is	be	VBZ
cord-000248-zueoyesj	697	8	a	a	DT
cord-000248-zueoyesj	697	9	trick	trick	NN
cord-000248-zueoyesj	697	10	of	of	IN
cord-000248-zueoyesj	697	11	escapologism	escapologism	NN
cord-000248-zueoyesj	697	12	,	,	,
cord-000248-zueoyesj	697	13	perhaps	perhaps	RB
cord-000248-zueoyesj	697	14	also	also	RB
cord-000248-zueoyesj	697	15	paralleled	parallel	VBN
cord-000248-zueoyesj	697	16	by	by	IN
cord-000248-zueoyesj	697	17	what	what	WP
cord-000248-zueoyesj	697	18	a	a	DT
cord-000248-zueoyesj	697	19	cancer	cancer	NN
cord-000248-zueoyesj	697	20	cell	cell	NN
cord-000248-zueoyesj	697	21	may	may	MD
cord-000248-zueoyesj	697	22	be	be	VB
cord-000248-zueoyesj	697	23	experiencing	experience	VBG
cord-000248-zueoyesj	697	24	(	(	-LRB-
cord-000248-zueoyesj	697	25	or	or	CC
cord-000248-zueoyesj	697	26	'	'	''
cord-000248-zueoyesj	697	27	'	'	''
cord-000248-zueoyesj	697	28	reacting	react	VBG
cord-000248-zueoyesj	697	29	'	'	''
cord-000248-zueoyesj	697	30	'	'	''
cord-000248-zueoyesj	698	1	in	in	IN
cord-000248-zueoyesj	698	2	response	response	NN
cord-000248-zueoyesj	698	3	to	to	IN
cord-000248-zueoyesj	698	4	increased	increase	VBN
cord-000248-zueoyesj	698	5	sources	source	NNS
cord-000248-zueoyesj	698	6	of	of	IN
cord-000248-zueoyesj	698	7	stresses	stress	NNS
cord-000248-zueoyesj	698	8	)	)	-RRB-
cord-000248-zueoyesj	698	9	,	,	,
cord-000248-zueoyesj	698	10	and	and	CC
cord-000248-zueoyesj	698	11	it	-PRON-	PRP
cord-000248-zueoyesj	698	12	is	be	VBZ
cord-000248-zueoyesj	698	13	worth	worth	JJ
cord-000248-zueoyesj	698	14	discussing	discuss	VBG
cord-000248-zueoyesj	698	15	in	in	IN
cord-000248-zueoyesj	698	16	this	this	DT
cord-000248-zueoyesj	698	17	context	context	NN
cord-000248-zueoyesj	698	18	.	.	.
cord-000248-zueoyesj	699	1	Let	let	VB
cord-000248-zueoyesj	699	2	H[X	H[X	NNP
cord-000248-zueoyesj	699	3	]	]	-RRB-
cord-000248-zueoyesj	699	4	be	be	VB
cord-000248-zueoyesj	699	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	699	6	Entropy	Entropy	NNP
cord-000248-zueoyesj	699	7	for	for	IN
cord-000248-zueoyesj	699	8	an	an	DT
cord-000248-zueoyesj	699	9	ensamble	ensamble	NN
cord-000248-zueoyesj	699	10	X	x	NN
cord-000248-zueoyesj	699	11	with	with	IN
cord-000248-zueoyesj	699	12	N	n	CD
cord-000248-zueoyesj	699	13	different	different	JJ
cord-000248-zueoyesj	699	14	values	value	NNS
cord-000248-zueoyesj	699	15	.	.	.
cord-000248-zueoyesj	700	1	We	-PRON-	PRP
cord-000248-zueoyesj	700	2	will	will	MD
cord-000248-zueoyesj	700	3	now	now	RB
cord-000248-zueoyesj	700	4	assume	assume	VB
cord-000248-zueoyesj	700	5	,	,	,
cord-000248-zueoyesj	700	6	and	and	CC
cord-000248-zueoyesj	700	7	here	here	RB
cord-000248-zueoyesj	700	8	is	be	VBZ
cord-000248-zueoyesj	700	9	the	the	DT
cord-000248-zueoyesj	700	10	trick	trick	NN
cord-000248-zueoyesj	700	11	,	,	,
cord-000248-zueoyesj	700	12	that	that	IN
cord-000248-zueoyesj	700	13	N	n	NN
cord-000248-zueoyesj	700	14	is	be	VBZ
cord-000248-zueoyesj	700	15	not	not	RB
cord-000248-zueoyesj	700	16	a	a	DT
cord-000248-zueoyesj	700	17	constant	constant	JJ
cord-000248-zueoyesj	700	18	,	,	,
cord-000248-zueoyesj	700	19	but	but	CC
cord-000248-zueoyesj	700	20	a	a	DT
cord-000248-zueoyesj	700	21	function	function	NN
cord-000248-zueoyesj	700	22	of	of	IN
cord-000248-zueoyesj	700	23	time	time	NN
cord-000248-zueoyesj	700	24	N(t	N(t	NNP
cord-000248-zueoyesj	700	25	)	)	-RRB-
cord-000248-zueoyesj	700	26	.	.	.
cord-000248-zueoyesj	701	1	Let	let	VB
cord-000248-zueoyesj	701	2	D(X	D(X	NNP
cord-000248-zueoyesj	701	3	(	(	-LRB-
cord-000248-zueoyesj	701	4	N(t	N(t	NNP
cord-000248-zueoyesj	701	5	)	)	-RRB-
cord-000248-zueoyesj	701	6	)	)	-RRB-
cord-000248-zueoyesj	701	7	)	)	-RRB-
cord-000248-zueoyesj	701	8	be	be	VB
cord-000248-zueoyesj	701	9	the	the	DT
cord-000248-zueoyesj	701	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	701	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	701	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	701	13	.	.	.
cord-000248-zueoyesj	702	1	By	by	IN
cord-000248-zueoyesj	702	2	definition	definition	NN
cord-000248-zueoyesj	702	3	D(X(N(t	D(X(N(t	NNP
cord-000248-zueoyesj	702	4	)	)	-RRB-
cord-000248-zueoyesj	702	5	)	)	-RRB-
cord-000248-zueoyesj	702	6	)	)	-RRB-
cord-000248-zueoyesj	703	1	=	=	NFP
cord-000248-zueoyesj	704	1	H(X(N(t)))/log	h(x(n(t)))/log	RB
cord-000248-zueoyesj	704	2	2	2	CD
cord-000248-zueoyesj	704	3	(	(	-LRB-
cord-000248-zueoyesj	704	4	N(t	N(t	NNP
cord-000248-zueoyesj	704	5	)	)	-RRB-
cord-000248-zueoyesj	704	6	)	)	-RRB-
cord-000248-zueoyesj	704	7	.	.	.
cord-000248-zueoyesj	705	1	Then	then	RB
cord-000248-zueoyesj	705	2	,	,	,
cord-000248-zueoyesj	705	3	just	just	RB
cord-000248-zueoyesj	705	4	by	by	IN
cord-000248-zueoyesj	705	5	taking	take	VBG
cord-000248-zueoyesj	705	6	the	the	DT
cord-000248-zueoyesj	705	7	time	time	NN
cord-000248-zueoyesj	705	8	derivatives	derivative	NNS
cord-000248-zueoyesj	705	9	it	-PRON-	PRP
cord-000248-zueoyesj	705	10	can	can	MD
cord-000248-zueoyesj	705	11	be	be	VB
cord-000248-zueoyesj	705	12	shown	show	VBN
cord-000248-zueoyesj	705	13	that	that	IN
cord-000248-zueoyesj	705	14	the	the	DT
cord-000248-zueoyesj	705	15	time	time	NN
cord-000248-zueoyesj	705	16	variation	variation	NN
cord-000248-zueoyesj	705	17	of	of	IN
cord-000248-zueoyesj	705	18	D(X(N(t	D(X(N(t	NNP
cord-000248-zueoyesj	705	19	)	)	-RRB-
cord-000248-zueoyesj	705	20	)	)	-RRB-
cord-000248-zueoyesj	705	21	)	)	-RRB-
cord-000248-zueoyesj	705	22	can	can	MD
cord-000248-zueoyesj	705	23	be	be	VB
cord-000248-zueoyesj	705	24	negative	negative	JJ
cord-000248-zueoyesj	705	25	,	,	,
cord-000248-zueoyesj	705	26	although	although	IN
cord-000248-zueoyesj	705	27	the	the	DT
cord-000248-zueoyesj	705	28	time	time	NN
cord-000248-zueoyesj	705	29	rate	rate	NN
cord-000248-zueoyesj	705	30	of	of	IN
cord-000248-zueoyesj	705	31	H[X	H[X	NNP
cord-000248-zueoyesj	705	32	]	]	-RRB-
cord-000248-zueoyesj	705	33	can	can	MD
cord-000248-zueoyesj	705	34	be	be	VB
cord-000248-zueoyesj	705	35	positive	positive	JJ
cord-000248-zueoyesj	705	36	.	.	.
cord-000248-zueoyesj	706	1	where	where	WRB
cord-000248-zueoyesj	706	2	k	k	NNP
cord-000248-zueoyesj	706	3	is	be	VBZ
cord-000248-zueoyesj	706	4	a	a	DT
cord-000248-zueoyesj	706	5	constant	constant	NN
cord-000248-zueoyesj	706	6	.	.	.
cord-000248-zueoyesj	707	1	The	the	DT
cord-000248-zueoyesj	707	2	escape	escape	NN
cord-000248-zueoyesj	707	3	to	to	IN
cord-000248-zueoyesj	707	4	our	-PRON-	PRP$
cord-000248-zueoyesj	707	5	paradox	paradox	NN
cord-000248-zueoyesj	707	6	is	be	VBZ
cord-000248-zueoyesj	707	7	'	'	``
cord-000248-zueoyesj	707	8	'	'	``
cord-000248-zueoyesj	707	9	achieved	achieve	VBN
cord-000248-zueoyesj	707	10	'	'	''
cord-000248-zueoyesj	707	11	'	'	''
cord-000248-zueoyesj	707	12	via	via	IN
cord-000248-zueoyesj	707	13	making	make	VBG
cord-000248-zueoyesj	707	14	explicit	explicit	JJ
cord-000248-zueoyesj	707	15	the	the	DT
cord-000248-zueoyesj	707	16	time	time	NN
cord-000248-zueoyesj	707	17	variability	variability	NN
cord-000248-zueoyesj	707	18	of	of	IN
cord-000248-zueoyesj	707	19	N(t	N(t	NNP
cord-000248-zueoyesj	707	20	)	)	-RRB-
cord-000248-zueoyesj	707	21	.	.	.
cord-000248-zueoyesj	708	1	Landberg	Landberg	NNP
cord-000248-zueoyesj	708	2	explicitly	explicitly	RB
cord-000248-zueoyesj	708	3	mentions	mention	VBZ
cord-000248-zueoyesj	708	4	that	that	IN
cord-000248-zueoyesj	708	5	biological	biological	JJ
cord-000248-zueoyesj	708	6	systems	system	NNS
cord-000248-zueoyesj	708	7	are	be	VBP
cord-000248-zueoyesj	708	8	examples	example	NNS
cord-000248-zueoyesj	708	9	where	where	WRB
cord-000248-zueoyesj	708	10	growth	growth	NN
cord-000248-zueoyesj	708	11	processes	process	NNS
cord-000248-zueoyesj	708	12	increase	increase	VBP
cord-000248-zueoyesj	708	13	N(t	N(t	NNP
cord-000248-zueoyesj	708	14	)	)	-RRB-
cord-000248-zueoyesj	708	15	,	,	,
cord-000248-zueoyesj	708	16	and	and	CC
cord-000248-zueoyesj	708	17	perhaps	perhaps	RB
cord-000248-zueoyesj	708	18	the	the	DT
cord-000248-zueoyesj	708	19	increased	increase	VBN
cord-000248-zueoyesj	708	20	diversity	diversity	NN
cord-000248-zueoyesj	708	21	in	in	IN
cord-000248-zueoyesj	708	22	the	the	DT
cord-000248-zueoyesj	708	23	transcriptome	transcriptome	NN
cord-000248-zueoyesj	708	24	of	of	IN
cord-000248-zueoyesj	708	25	a	a	DT
cord-000248-zueoyesj	708	26	cancer	cancer	NN
cord-000248-zueoyesj	708	27	cell	cell	NN
cord-000248-zueoyesj	708	28	during	during	IN
cord-000248-zueoyesj	708	29	progression	progression	NN
cord-000248-zueoyesj	708	30	is	be	VBZ
cord-000248-zueoyesj	708	31	one	one	CD
cord-000248-zueoyesj	708	32	of	of	IN
cord-000248-zueoyesj	708	33	such	such	JJ
cord-000248-zueoyesj	708	34	examples	example	NNS
cord-000248-zueoyesj	708	35	.	.	.
cord-000248-zueoyesj	709	1	This	this	DT
cord-000248-zueoyesj	709	2	discussion	discussion	NN
cord-000248-zueoyesj	709	3	somehow	somehow	RB
cord-000248-zueoyesj	709	4	resolves	resolve	VBZ
cord-000248-zueoyesj	709	5	the	the	DT
cord-000248-zueoyesj	709	6	apparent	apparent	JJ
cord-000248-zueoyesj	709	7	disassociations	disassociation	NNS
cord-000248-zueoyesj	709	8	due	due	JJ
cord-000248-zueoyesj	709	9	to	to	IN
cord-000248-zueoyesj	709	10	language	language	NN
cord-000248-zueoyesj	709	11	barriers	barrier	NNS
cord-000248-zueoyesj	709	12	that	that	WDT
cord-000248-zueoyesj	709	13	may	may	MD
cord-000248-zueoyesj	709	14	exist	exist	VB
cord-000248-zueoyesj	709	15	between	between	IN
cord-000248-zueoyesj	709	16	the	the	DT
cord-000248-zueoyesj	709	17	different	different	JJ
cord-000248-zueoyesj	709	18	disciplines	discipline	NNS
cord-000248-zueoyesj	709	19	(	(	-LRB-
cord-000248-zueoyesj	709	20	physics	physics	NN
cord-000248-zueoyesj	709	21	,	,	,
cord-000248-zueoyesj	709	22	information	information	NN
cord-000248-zueoyesj	709	23	theory	theory	NN
cord-000248-zueoyesj	709	24	,	,	,
cord-000248-zueoyesj	709	25	molecular	molecular	JJ
cord-000248-zueoyesj	709	26	biology	biology	NN
cord-000248-zueoyesj	709	27	and	and	CC
cord-000248-zueoyesj	709	28	oncology	oncology	NN
cord-000248-zueoyesj	709	29	)	)	-RRB-
cord-000248-zueoyesj	709	30	.	.	.
cord-000248-zueoyesj	710	1	A	a	DT
cord-000248-zueoyesj	710	2	biologist	biologist	NN
cord-000248-zueoyesj	710	3	may	may	MD
cord-000248-zueoyesj	710	4	regard	regard	VB
cord-000248-zueoyesj	710	5	a	a	DT
cord-000248-zueoyesj	710	6	cancer	cancer	NN
cord-000248-zueoyesj	710	7	cell	cell	NN
cord-000248-zueoyesj	710	8	as	as	IN
cord-000248-zueoyesj	710	9	an	an	DT
cord-000248-zueoyesj	710	10	entity	entity	NN
cord-000248-zueoyesj	710	11	that	that	WDT
cord-000248-zueoyesj	710	12	,	,	,
cord-000248-zueoyesj	710	13	during	during	IN
cord-000248-zueoyesj	710	14	progression	progression	NN
cord-000248-zueoyesj	710	15	,	,	,
cord-000248-zueoyesj	710	16	may	may	MD
cord-000248-zueoyesj	710	17	'	'	''
cord-000248-zueoyesj	710	18	'	'	``
cord-000248-zueoyesj	710	19	spread	spread	VB
cord-000248-zueoyesj	710	20	'	'	''
cord-000248-zueoyesj	710	21	'	'	''
cord-000248-zueoyesj	710	22	its	-PRON-	PRP$
cord-000248-zueoyesj	710	23	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	710	24	profile	profile	NN
cord-000248-zueoyesj	710	25	,	,	,
cord-000248-zueoyesj	710	26	including	include	VBG
cord-000248-zueoyesj	710	27	the	the	DT
cord-000248-zueoyesj	710	28	generation	generation	NN
cord-000248-zueoyesj	710	29	of	of	IN
cord-000248-zueoyesj	710	30	a	a	DT
cord-000248-zueoyesj	710	31	large	large	JJ
cord-000248-zueoyesj	710	32	number	number	NN
cord-000248-zueoyesj	710	33	of	of	IN
cord-000248-zueoyesj	710	34	novel	novel	JJ
cord-000248-zueoyesj	710	35	molecular	molecular	JJ
cord-000248-zueoyesj	710	36	species	specie	NNS
cord-000248-zueoyesj	710	37	(	(	-LRB-
cord-000248-zueoyesj	710	38	due	due	IN
cord-000248-zueoyesj	710	39	to	to	IN
cord-000248-zueoyesj	710	40	adquired	adquire	VBN
cord-000248-zueoyesj	710	41	characteristics	characteristic	NNS
cord-000248-zueoyesj	710	42	during	during	IN
cord-000248-zueoyesj	710	43	its	-PRON-	PRP$
cord-000248-zueoyesj	710	44	'	'	``
cord-000248-zueoyesj	710	45	'	'	``
cord-000248-zueoyesj	710	46	devolution	devolution	NN
cord-000248-zueoyesj	710	47	'	'	''
cord-000248-zueoyesj	710	48	'	'	''
cord-000248-zueoyesj	710	49	from	from	IN
cord-000248-zueoyesj	710	50	the	the	DT
cord-000248-zueoyesj	710	51	normal	normal	JJ
cord-000248-zueoyesj	710	52	type	type	NN
cord-000248-zueoyesj	710	53	)	)	-RRB-
cord-000248-zueoyesj	710	54	.	.	.
cord-000248-zueoyesj	711	1	In	in	IN
cord-000248-zueoyesj	711	2	our	-PRON-	PRP$
cord-000248-zueoyesj	711	3	informational	informational	JJ
cord-000248-zueoyesj	711	4	perspective	perspective	NN
cord-000248-zueoyesj	711	5	,	,	,
cord-000248-zueoyesj	711	6	this	this	DT
cord-000248-zueoyesj	711	7	would	would	MD
cord-000248-zueoyesj	711	8	be	be	VB
cord-000248-zueoyesj	711	9	analogous	analogous	JJ
cord-000248-zueoyesj	711	10	to	to	IN
cord-000248-zueoyesj	711	11	a	a	DT
cord-000248-zueoyesj	711	12	situation	situation	NN
cord-000248-zueoyesj	711	13	in	in	IN
cord-000248-zueoyesj	711	14	which	which	WDT
cord-000248-zueoyesj	711	15	the	the	DT
cord-000248-zueoyesj	711	16	sender	sender	NN
cord-000248-zueoyesj	711	17	of	of	IN
cord-000248-zueoyesj	711	18	a	a	DT
cord-000248-zueoyesj	711	19	message	message	NN
cord-000248-zueoyesj	711	20	,	,	,
cord-000248-zueoyesj	711	21	after	after	IN
cord-000248-zueoyesj	711	22	some	some	DT
cord-000248-zueoyesj	711	23	time	time	NN
cord-000248-zueoyesj	711	24	,	,	,
cord-000248-zueoyesj	711	25	decides	decide	VBZ
cord-000248-zueoyesj	711	26	to	to	TO
cord-000248-zueoyesj	711	27	increase	increase	VB
cord-000248-zueoyesj	711	28	the	the	DT
cord-000248-zueoyesj	711	29	size	size	NN
cord-000248-zueoyesj	711	30	of	of	IN
cord-000248-zueoyesj	711	31	the	the	DT
cord-000248-zueoyesj	711	32	alphabet	alphabet	NN
cord-000248-zueoyesj	711	33	of	of	IN
cord-000248-zueoyesj	711	34	transmitted	transmit	VBN
cord-000248-zueoyesj	711	35	symbols	symbol	NNS
cord-000248-zueoyesj	711	36	.	.	.
cord-000248-zueoyesj	712	1	Clearly	clearly	RB
cord-000248-zueoyesj	712	2	,	,	,
cord-000248-zueoyesj	712	3	it	-PRON-	PRP
cord-000248-zueoyesj	712	4	is	be	VBZ
cord-000248-zueoyesj	712	5	intuitive	intuitive	JJ
cord-000248-zueoyesj	712	6	to	to	TO
cord-000248-zueoyesj	712	7	think	think	VB
cord-000248-zueoyesj	712	8	that	that	IN
cord-000248-zueoyesj	712	9	the	the	DT
cord-000248-zueoyesj	712	10	receiver	receiver	NN
cord-000248-zueoyesj	712	11	would	would	MD
cord-000248-zueoyesj	712	12	be	be	VB
cord-000248-zueoyesj	712	13	in	in	IN
cord-000248-zueoyesj	712	14	a	a	DT
cord-000248-zueoyesj	712	15	situation	situation	NN
cord-000248-zueoyesj	712	16	of	of	IN
cord-000248-zueoyesj	712	17	increased	increase	VBN
cord-000248-zueoyesj	712	18	Shannon	Shannon	NNP
cord-000248-zueoyesj	712	19	Entropy	Entropy	NNP
cord-000248-zueoyesj	712	20	.	.	.
cord-000248-zueoyesj	713	1	However	however	RB
cord-000248-zueoyesj	713	2	,	,	,
cord-000248-zueoyesj	713	3	if	if	IN
cord-000248-zueoyesj	713	4	the	the	DT
cord-000248-zueoyesj	713	5	receiver	receiver	NN
cord-000248-zueoyesj	713	6	is	be	VBZ
cord-000248-zueoyesj	713	7	not	not	RB
cord-000248-zueoyesj	713	8	aware	aware	JJ
cord-000248-zueoyesj	713	9	of	of	IN
cord-000248-zueoyesj	713	10	the	the	DT
cord-000248-zueoyesj	713	11	new	new	JJ
cord-000248-zueoyesj	713	12	symbols	symbol	NNS
cord-000248-zueoyesj	713	13	(	(	-LRB-
cord-000248-zueoyesj	713	14	or	or	CC
cord-000248-zueoyesj	713	15	is	be	VBZ
cord-000248-zueoyesj	713	16	not	not	RB
cord-000248-zueoyesj	713	17	able	able	JJ
cord-000248-zueoyesj	713	18	to	to	TO
cord-000248-zueoyesj	713	19	detect	detect	VB
cord-000248-zueoyesj	713	20	them	-PRON-	PRP
cord-000248-zueoyesj	713	21	)	)	-RRB-
cord-000248-zueoyesj	713	22	and	and	CC
cord-000248-zueoyesj	713	23	some	some	DT
cord-000248-zueoyesj	713	24	of	of	IN
cord-000248-zueoyesj	713	25	the	the	DT
cord-000248-zueoyesj	713	26	symbols	symbol	NNS
cord-000248-zueoyesj	713	27	of	of	IN
cord-000248-zueoyesj	713	28	the	the	DT
cord-000248-zueoyesj	713	29	previous	previous	JJ
cord-000248-zueoyesj	713	30	alphabet	alphabet	NN
cord-000248-zueoyesj	713	31	are	be	VBP
cord-000248-zueoyesj	713	32	no	no	RB
cord-000248-zueoyesj	713	33	longer	long	RBR
cord-000248-zueoyesj	713	34	used	use	VBN
cord-000248-zueoyesj	713	35	,	,	,
cord-000248-zueoyesj	713	36	the	the	DT
cord-000248-zueoyesj	713	37	receiver	receiver	NN
cord-000248-zueoyesj	713	38	would	would	MD
cord-000248-zueoyesj	713	39	now	now	RB
cord-000248-zueoyesj	713	40	perceive	perceive	VB
cord-000248-zueoyesj	713	41	a	a	DT
cord-000248-zueoyesj	713	42	reduction	reduction	NN
cord-000248-zueoyesj	713	43	of	of	IN
cord-000248-zueoyesj	713	44	Normalized	Normalized	NNP
cord-000248-zueoyesj	713	45	Shannon	Shannon	NNP
cord-000248-zueoyesj	713	46	Entropy	Entropy	NNP
cord-000248-zueoyesj	713	47	,	,	,
cord-000248-zueoyesj	713	48	observing	observe	VBG
cord-000248-zueoyesj	713	49	an	an	DT
cord-000248-zueoyesj	713	50	increasing	increase	VBG
cord-000248-zueoyesj	713	51	order	order	NN
cord-000248-zueoyesj	713	52	.	.	.
cord-000248-zueoyesj	714	1	We	-PRON-	PRP
cord-000248-zueoyesj	714	2	now	now	RB
cord-000248-zueoyesj	714	3	borrow	borrow	VBP
cord-000248-zueoyesj	714	4	an	an	DT
cord-000248-zueoyesj	714	5	illustrative	illustrative	JJ
cord-000248-zueoyesj	714	6	example	example	NN
cord-000248-zueoyesj	714	7	from	from	IN
cord-000248-zueoyesj	714	8	Landberg	Landberg	NNP
cord-000248-zueoyesj	714	9	[	[	-LRB-
cord-000248-zueoyesj	714	10	623	623	CD
cord-000248-zueoyesj	714	11	]	]	-RRB-
cord-000248-zueoyesj	714	12	,	,	,
cord-000248-zueoyesj	714	13	but	but	CC
cord-000248-zueoyesj	714	14	we	-PRON-	PRP
cord-000248-zueoyesj	714	15	add	add	VBP
cord-000248-zueoyesj	714	16	a	a	DT
cord-000248-zueoyesj	714	17	twist	twist	NN
cord-000248-zueoyesj	714	18	to	to	IN
cord-000248-zueoyesj	714	19	this	this	DT
cord-000248-zueoyesj	714	20	argument	argument	NN
cord-000248-zueoyesj	714	21	for	for	IN
cord-000248-zueoyesj	714	22	the	the	DT
cord-000248-zueoyesj	714	23	purpose	purpose	NN
cord-000248-zueoyesj	714	24	of	of	IN
cord-000248-zueoyesj	714	25	illustrating	illustrate	VBG
cord-000248-zueoyesj	714	26	this	this	DT
cord-000248-zueoyesj	714	27	discussion	discussion	NN
cord-000248-zueoyesj	714	28	.	.	.
cord-000248-zueoyesj	715	1	Suppose	suppose	VB
cord-000248-zueoyesj	715	2	we	-PRON-	PRP
cord-000248-zueoyesj	715	3	have	have	VBP
cord-000248-zueoyesj	715	4	a	a	DT
cord-000248-zueoyesj	715	5	sender	sender	NN
cord-000248-zueoyesj	715	6	transmitting	transmit	VBG
cord-000248-zueoyesj	715	7	only	only	RB
cord-000248-zueoyesj	715	8	two	two	CD
cord-000248-zueoyesj	715	9	possible	possible	JJ
cord-000248-zueoyesj	715	10	symbols	symbol	NNS
cord-000248-zueoyesj	715	11	(	(	-LRB-
cord-000248-zueoyesj	715	12	N	n	NN
cord-000248-zueoyesj	715	13	=	=	SYM
cord-000248-zueoyesj	715	14	2	2	CD
cord-000248-zueoyesj	715	15	)	)	-RRB-
cord-000248-zueoyesj	715	16	,	,	,
cord-000248-zueoyesj	715	17	and	and	CC
cord-000248-zueoyesj	715	18	we	-PRON-	PRP
cord-000248-zueoyesj	715	19	will	will	MD
cord-000248-zueoyesj	715	20	assume	assume	VB
cord-000248-zueoyesj	715	21	that	that	IN
cord-000248-zueoyesj	715	22	we	-PRON-	PRP
cord-000248-zueoyesj	715	23	have	have	VBP
cord-000248-zueoyesj	715	24	the	the	DT
cord-000248-zueoyesj	715	25	same	same	JJ
cord-000248-zueoyesj	715	26	probability	probability	NN
cord-000248-zueoyesj	715	27	,	,	,
cord-000248-zueoyesj	715	28	let	let	VB
cord-000248-zueoyesj	715	29	's	-PRON-	PRP
cord-000248-zueoyesj	715	30	denote	denote	VB
cord-000248-zueoyesj	715	31	this	this	DT
cord-000248-zueoyesj	715	32	as	as	IN
cord-000248-zueoyesj	715	33	(	(	-LRB-
cord-000248-zueoyesj	715	34	1/2	1/2	CD
cord-000248-zueoyesj	715	35	,	,	,
cord-000248-zueoyesj	715	36	1/2	1/2	CD
cord-000248-zueoyesj	715	37	)	)	-RRB-
cord-000248-zueoyesj	715	38	.	.	.
cord-000248-zueoyesj	716	1	Then	then	RB
cord-000248-zueoyesj	716	2	the	the	DT
cord-000248-zueoyesj	716	3	average	average	JJ
cord-000248-zueoyesj	716	4	expected	expect	VBN
cord-000248-zueoyesj	716	5	surprisal	surprisal	NNP
cord-000248-zueoyesj	716	6	(	(	-LRB-
cord-000248-zueoyesj	716	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	716	8	Entropy	Entropy	NNP
cord-000248-zueoyesj	716	9	)	)	-RRB-
cord-000248-zueoyesj	716	10	,	,	,
cord-000248-zueoyesj	716	11	is	be	VBZ
cord-000248-zueoyesj	716	12	H(X	H(X	NNP
cord-000248-zueoyesj	716	13	)	)	-RRB-
cord-000248-zueoyesj	716	14	=	=	.
cord-000248-zueoyesj	717	1	1	1	CD
cord-000248-zueoyesj	717	2	,	,	,
cord-000248-zueoyesj	717	3	and	and	CC
cord-000248-zueoyesj	717	4	the	the	DT
cord-000248-zueoyesj	717	5	Normalized	Normalized	NNP
cord-000248-zueoyesj	717	6	Shannon	Shannon	NNP
cord-000248-zueoyesj	717	7	Entropy	Entropy	NNP
cord-000248-zueoyesj	717	8	is	be	VBZ
cord-000248-zueoyesj	717	9	also	also	RB
cord-000248-zueoyesj	717	10	equal	equal	JJ
cord-000248-zueoyesj	717	11	to	to	IN
cord-000248-zueoyesj	717	12	one	one	CD
cord-000248-zueoyesj	717	13	.	.	.
cord-000248-zueoyesj	718	1	Assume	assume	VB
cord-000248-zueoyesj	718	2	now	now	RB
cord-000248-zueoyesj	718	3	that	that	IN
cord-000248-zueoyesj	718	4	now	now	RB
cord-000248-zueoyesj	718	5	our	-PRON-	PRP$
cord-000248-zueoyesj	718	6	sender	sender	NN
cord-000248-zueoyesj	718	7	starts	start	VBZ
cord-000248-zueoyesj	718	8	to	to	TO
cord-000248-zueoyesj	718	9	transmit	transmit	VB
cord-000248-zueoyesj	718	10	using	use	VBG
cord-000248-zueoyesj	718	11	another	another	DT
cord-000248-zueoyesj	718	12	symbol	symbol	NN
cord-000248-zueoyesj	718	13	,	,	,
cord-000248-zueoyesj	718	14	so	so	IN
cord-000248-zueoyesj	718	15	that	that	IN
cord-000248-zueoyesj	718	16	we	-PRON-	PRP
cord-000248-zueoyesj	718	17	now	now	RB
cord-000248-zueoyesj	718	18	have	have	VBP
cord-000248-zueoyesj	718	19	theoretical	theoretical	JJ
cord-000248-zueoyesj	718	20	probabilities	probability	NNS
cord-000248-zueoyesj	718	21	of	of	IN
cord-000248-zueoyesj	718	22	(	(	-LRB-
cord-000248-zueoyesj	718	23	0.5	0.5	CD
cord-000248-zueoyesj	718	24	,	,	,
cord-000248-zueoyesj	718	25	0.25	0.25	CD
cord-000248-zueoyesj	718	26	,	,	,
cord-000248-zueoyesj	718	27	0.25	0.25	CD
cord-000248-zueoyesj	718	28	)	)	-RRB-
cord-000248-zueoyesj	718	29	.	.	.
cord-000248-zueoyesj	719	1	Then	then	RB
cord-000248-zueoyesj	719	2	N	n	NN
cord-000248-zueoyesj	719	3	=	=	SYM
cord-000248-zueoyesj	719	4	3	3	CD
cord-000248-zueoyesj	719	5	,	,	,
cord-000248-zueoyesj	719	6	and	and	CC
cord-000248-zueoyesj	719	7	the	the	DT
cord-000248-zueoyesj	719	8	average	average	JJ
cord-000248-zueoyesj	719	9	expected	expect	VBN
cord-000248-zueoyesj	719	10	surprisal	surprisal	NNP
cord-000248-zueoyesj	719	11	increases	increase	VBZ
cord-000248-zueoyesj	719	12	to	to	IN
cord-000248-zueoyesj	719	13	H(X9	H(X9	NNP
cord-000248-zueoyesj	719	14	)	)	-RRB-
cord-000248-zueoyesj	719	15	=	=	NFP
cord-000248-zueoyesj	720	1	1.5	1.5	CD
cord-000248-zueoyesj	721	1	the	the	DT
cord-000248-zueoyesj	721	2	Normalized	Normalized	NNP
cord-000248-zueoyesj	721	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	721	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	721	5	is	be	VBZ
cord-000248-zueoyesj	721	6	now	now	RB
cord-000248-zueoyesj	721	7	1.5	1.5	CD
cord-000248-zueoyesj	721	8	/	/	SYM
cord-000248-zueoyesj	721	9	log	log	NN
cord-000248-zueoyesj	721	10	2	2	CD
cord-000248-zueoyesj	721	11	(	(	-LRB-
cord-000248-zueoyesj	721	12	3	3	CD
cord-000248-zueoyesj	721	13	)	)	-RRB-
cord-000248-zueoyesj	721	14	=	=	SYM
cord-000248-zueoyesj	721	15	0.946	0.946	CD
cord-000248-zueoyesj	721	16	…	…	NFP
cord-000248-zueoyesj	721	17	(	(	-LRB-
cord-000248-zueoyesj	721	18	a	a	DT
cord-000248-zueoyesj	721	19	reduction	reduction	NN
cord-000248-zueoyesj	721	20	)	)	-RRB-
cord-000248-zueoyesj	721	21	.	.	.
cord-000248-zueoyesj	722	1	This	this	DT
cord-000248-zueoyesj	722	2	'	'	``
cord-000248-zueoyesj	722	3	third	third	JJ
cord-000248-zueoyesj	722	4	symbol	symbol	NN
cord-000248-zueoyesj	722	5	'	'	''
cord-000248-zueoyesj	722	6	could	could	MD
cord-000248-zueoyesj	722	7	actually	actually	RB
cord-000248-zueoyesj	722	8	represent	represent	VB
cord-000248-zueoyesj	722	9	a	a	DT
cord-000248-zueoyesj	722	10	new	new	JJ
cord-000248-zueoyesj	722	11	'	'	''
cord-000248-zueoyesj	722	12	'	'	''
cord-000248-zueoyesj	722	13	molecular	molecular	JJ
cord-000248-zueoyesj	722	14	species	specie	NNS
cord-000248-zueoyesj	722	15	'	'	''
cord-000248-zueoyesj	722	16	'	'	''
cord-000248-zueoyesj	722	17	or	or	CC
cord-000248-zueoyesj	722	18	a	a	DT
cord-000248-zueoyesj	722	19	protein	protein	NN
cord-000248-zueoyesj	722	20	isoform	isoform	NN
cord-000248-zueoyesj	722	21	that	that	WDT
cord-000248-zueoyesj	722	22	would	would	MD
cord-000248-zueoyesj	722	23	not	not	RB
cord-000248-zueoyesj	722	24	be	be	VB
cord-000248-zueoyesj	722	25	normally	normally	RB
cord-000248-zueoyesj	722	26	expressed	express	VBN
cord-000248-zueoyesj	722	27	in	in	IN
cord-000248-zueoyesj	722	28	that	that	DT
cord-000248-zueoyesj	722	29	tissue	tissue	NN
cord-000248-zueoyesj	722	30	type	type	NN
cord-000248-zueoyesj	722	31	[	[	-LRB-
cord-000248-zueoyesj	722	32	624	624	CD
cord-000248-zueoyesj	722	33	]	]	-RRB-
cord-000248-zueoyesj	722	34	,	,	,
cord-000248-zueoyesj	722	35	or	or	CC
cord-000248-zueoyesj	722	36	even	even	RB
cord-000248-zueoyesj	722	37	something	something	NN
cord-000248-zueoyesj	722	38	entirely	entirely	RB
cord-000248-zueoyesj	722	39	new	new	JJ
cord-000248-zueoyesj	722	40	,	,	,
cord-000248-zueoyesj	722	41	product	product	NN
cord-000248-zueoyesj	722	42	of	of	IN
cord-000248-zueoyesj	722	43	a	a	DT
cord-000248-zueoyesj	722	44	mutational	mutational	JJ
cord-000248-zueoyesj	722	45	/	/	SYM
cord-000248-zueoyesj	722	46	deletional	deletional	JJ
cord-000248-zueoyesj	722	47	event	event	NN
cord-000248-zueoyesj	722	48	.	.	.
cord-000248-zueoyesj	723	1	If	if	IN
cord-000248-zueoyesj	723	2	our	-PRON-	PRP$
cord-000248-zueoyesj	723	3	hypothetical	hypothetical	JJ
cord-000248-zueoyesj	723	4	high	high	JJ
cord-000248-zueoyesj	723	5	-	-	HYPH
cord-000248-zueoyesj	723	6	throughput	throughput	NN
cord-000248-zueoyesj	723	7	technology	technology	NN
cord-000248-zueoyesj	723	8	can	can	MD
cord-000248-zueoyesj	723	9	only	only	RB
cord-000248-zueoyesj	723	10	be	be	VB
cord-000248-zueoyesj	723	11	detecting	detect	VBG
cord-000248-zueoyesj	723	12	the	the	DT
cord-000248-zueoyesj	723	13	first	first	JJ
cord-000248-zueoyesj	723	14	two	two	CD
cord-000248-zueoyesj	723	15	symbols	symbol	NNS
cord-000248-zueoyesj	723	16	,	,	,
cord-000248-zueoyesj	723	17	and	and	CC
cord-000248-zueoyesj	723	18	following	follow	VBG
cord-000248-zueoyesj	723	19	the	the	DT
cord-000248-zueoyesj	723	20	conventions	convention	NNS
cord-000248-zueoyesj	723	21	we	-PRON-	PRP
cord-000248-zueoyesj	723	22	established	establish	VBD
cord-000248-zueoyesj	723	23	in	in	IN
cord-000248-zueoyesj	723	24	the	the	DT
cord-000248-zueoyesj	723	25	'	'	``
cord-000248-zueoyesj	723	26	Materials	Materials	NNPS
cord-000248-zueoyesj	723	27	and	and	CC
cord-000248-zueoyesj	723	28	Methods	Methods	NNPS
cord-000248-zueoyesj	723	29	'	'	POS
cord-000248-zueoyesj	723	30	section	section	NN
cord-000248-zueoyesj	723	31	,	,	,
cord-000248-zueoyesj	723	32	we	-PRON-	PRP
cord-000248-zueoyesj	723	33	would	would	MD
cord-000248-zueoyesj	723	34	be	be	VB
cord-000248-zueoyesj	723	35	'	'	``
cord-000248-zueoyesj	723	36	'	'	``
cord-000248-zueoyesj	723	37	observing	observe	VBG
cord-000248-zueoyesj	723	38	'	'	''
cord-000248-zueoyesj	723	39	'	'	''
cord-000248-zueoyesj	723	40	frequencies	frequency	NNS
cord-000248-zueoyesj	723	41	of	of	IN
cord-000248-zueoyesj	723	42	(	(	-LRB-
cord-000248-zueoyesj	723	43	2/3,1/	2/3,1/	CD
cord-000248-zueoyesj	723	44	3	3	CD
cord-000248-zueoyesj	723	45	)	)	-RRB-
cord-000248-zueoyesj	723	46	since	since	IN
cord-000248-zueoyesj	723	47	the	the	DT
cord-000248-zueoyesj	723	48	other	other	JJ
cord-000248-zueoyesj	723	49	events	event	NNS
cord-000248-zueoyesj	723	50	would	would	MD
cord-000248-zueoyesj	723	51	not	not	RB
cord-000248-zueoyesj	723	52	be	be	VB
cord-000248-zueoyesj	723	53	detected	detect	VBN
cord-000248-zueoyesj	723	54	with	with	IN
cord-000248-zueoyesj	723	55	our	-PRON-	PRP$
cord-000248-zueoyesj	723	56	equipment	equipment	NN
cord-000248-zueoyesj	723	57	.	.	.
cord-000248-zueoyesj	724	1	As	as	IN
cord-000248-zueoyesj	724	2	a	a	DT
cord-000248-zueoyesj	724	3	consequence	consequence	NN
cord-000248-zueoyesj	724	4	,	,	,
cord-000248-zueoyesj	724	5	the	the	DT
cord-000248-zueoyesj	724	6	both	both	PDT
cord-000248-zueoyesj	724	7	the	the	DT
cord-000248-zueoyesj	724	8	log	log	NN
cord-000248-zueoyesj	724	9	2	2	CD
cord-000248-zueoyesj	724	10	(	(	-LRB-
cord-000248-zueoyesj	724	11	2	2	CD
cord-000248-zueoyesj	724	12	)	)	-RRB-
cord-000248-zueoyesj	724	13	=	=	SYM
cord-000248-zueoyesj	724	14	1	1	CD
cord-000248-zueoyesj	724	15	,	,	,
cord-000248-zueoyesj	724	16	Shannon	Shannon	NNP
cord-000248-zueoyesj	724	17	Entropy	Entropy	NNP
cord-000248-zueoyesj	724	18	and	and	CC
cord-000248-zueoyesj	724	19	the	the	DT
cord-000248-zueoyesj	724	20	Normalized	Normalized	NNP
cord-000248-zueoyesj	724	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	724	22	Entropy	Entropy	NNP
cord-000248-zueoyesj	724	23	are	be	VBP
cord-000248-zueoyesj	724	24	both	both	RB
cord-000248-zueoyesj	724	25	reduced	reduce	VBN
cord-000248-zueoyesj	724	26	to	to	IN
cord-000248-zueoyesj	724	27	0.918293	0.918293	CD
cord-000248-zueoyesj	724	28	.	.	.
cord-000248-zueoyesj	725	1	Obviously	obviously	RB
cord-000248-zueoyesj	725	2	,	,	,
cord-000248-zueoyesj	725	3	we	-PRON-	PRP
cord-000248-zueoyesj	725	4	can	can	MD
cord-000248-zueoyesj	725	5	not	not	RB
cord-000248-zueoyesj	725	6	count	count	VB
cord-000248-zueoyesj	725	7	what	what	WP
cord-000248-zueoyesj	725	8	we	-PRON-	PRP
cord-000248-zueoyesj	725	9	can	can	MD
cord-000248-zueoyesj	725	10	not	not	RB
cord-000248-zueoyesj	725	11	observe	observe	VB
cord-000248-zueoyesj	725	12	.	.	.
cord-000248-zueoyesj	726	1	As	as	IN
cord-000248-zueoyesj	726	2	a	a	DT
cord-000248-zueoyesj	726	3	consequence	consequence	NN
cord-000248-zueoyesj	726	4	,	,	,
cord-000248-zueoyesj	726	5	a	a	DT
cord-000248-zueoyesj	726	6	degenerating	degenerate	VBG
cord-000248-zueoyesj	726	7	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	726	8	profile	profile	NN
cord-000248-zueoyesj	726	9	that	that	WDT
cord-000248-zueoyesj	726	10	produces	produce	VBZ
cord-000248-zueoyesj	726	11	novel	novel	JJ
cord-000248-zueoyesj	726	12	molecular	molecular	JJ
cord-000248-zueoyesj	726	13	species	specie	NNS
cord-000248-zueoyesj	726	14	,	,	,
cord-000248-zueoyesj	726	15	and	and	CC
cord-000248-zueoyesj	726	16	at	at	IN
cord-000248-zueoyesj	726	17	the	the	DT
cord-000248-zueoyesj	726	18	same	same	JJ
cord-000248-zueoyesj	726	19	time	time	NN
cord-000248-zueoyesj	726	20	reduces	reduce	VBZ
cord-000248-zueoyesj	726	21	those	those	DT
cord-000248-zueoyesj	726	22	which	which	WDT
cord-000248-zueoyesj	726	23	we	-PRON-	PRP
cord-000248-zueoyesj	726	24	can	can	MD
cord-000248-zueoyesj	726	25	not	not	RB
cord-000248-zueoyesj	726	26	measure	measure	VB
cord-000248-zueoyesj	726	27	with	with	IN
cord-000248-zueoyesj	726	28	a	a	DT
cord-000248-zueoyesj	726	29	particular	particular	JJ
cord-000248-zueoyesj	726	30	technology	technology	NN
cord-000248-zueoyesj	726	31	,	,	,
cord-000248-zueoyesj	726	32	would	would	MD
cord-000248-zueoyesj	726	33	look	look	VB
cord-000248-zueoyesj	726	34	increasingly	increasingly	RB
cord-000248-zueoyesj	726	35	more	more	RBR
cord-000248-zueoyesj	726	36	ordered	order	VBN
cord-000248-zueoyesj	726	37	.	.	.
cord-000248-zueoyesj	727	1	We	-PRON-	PRP
cord-000248-zueoyesj	727	2	envision	envision	VBP
cord-000248-zueoyesj	727	3	that	that	IN
cord-000248-zueoyesj	727	4	physicists	physicist	NNS
cord-000248-zueoyesj	727	5	may	may	MD
cord-000248-zueoyesj	727	6	find	find	VB
cord-000248-zueoyesj	727	7	here	here	RB
cord-000248-zueoyesj	727	8	a	a	DT
cord-000248-zueoyesj	727	9	fertile	fertile	JJ
cord-000248-zueoyesj	727	10	ground	ground	NN
cord-000248-zueoyesj	727	11	to	to	TO
cord-000248-zueoyesj	727	12	explore	explore	VB
cord-000248-zueoyesj	727	13	new	new	JJ
cord-000248-zueoyesj	727	14	ideas	idea	NNS
cord-000248-zueoyesj	727	15	and	and	CC
cord-000248-zueoyesj	727	16	attempt	attempt	VB
cord-000248-zueoyesj	727	17	novel	novel	JJ
cord-000248-zueoyesj	727	18	mathematical	mathematical	JJ
cord-000248-zueoyesj	727	19	formalisms	formalism	NNS
cord-000248-zueoyesj	727	20	for	for	IN
cord-000248-zueoyesj	727	21	cancer	cancer	NN
cord-000248-zueoyesj	727	22	progression	progression	NN
cord-000248-zueoyesj	727	23	from	from	IN
cord-000248-zueoyesj	727	24	the	the	DT
cord-000248-zueoyesj	727	25	realm	realm	NN
cord-000248-zueoyesj	727	26	of	of	IN
cord-000248-zueoyesj	727	27	finite	finite	JJ
cord-000248-zueoyesj	727	28	-	-	HYPH
cord-000248-zueoyesj	727	29	state	state	NN
cord-000248-zueoyesj	727	30	thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	727	31	[	[	-LRB-
cord-000248-zueoyesj	727	32	625	625	CD
cord-000248-zueoyesj	727	33	]	]	-RRB-
cord-000248-zueoyesj	727	34	and	and	CC
cord-000248-zueoyesj	727	35	in	in	IN
cord-000248-zueoyesj	727	36	particular	particular	JJ
cord-000248-zueoyesj	727	37	endorevesible	endorevesible	JJ
cord-000248-zueoyesj	727	38	processes	process	NNS
cord-000248-zueoyesj	727	39	[	[	-LRB-
cord-000248-zueoyesj	727	40	626	626	CD
cord-000248-zueoyesj	727	41	]	]	-RRB-
cord-000248-zueoyesj	727	42	and	and	CC
cord-000248-zueoyesj	727	43	endoreversible	endoreversible	JJ
cord-000248-zueoyesj	727	44	thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	727	45	[	[	-LRB-
cord-000248-zueoyesj	727	46	627	627	CD
cord-000248-zueoyesj	727	47	]	]	-RRB-
cord-000248-zueoyesj	727	48	.	.	.
cord-000248-zueoyesj	728	1	Some	some	DT
cord-000248-zueoyesj	728	2	molecular	molecular	JJ
cord-000248-zueoyesj	728	3	alterations	alteration	NNS
cord-000248-zueoyesj	728	4	would	would	MD
cord-000248-zueoyesj	728	5	then	then	RB
cord-000248-zueoyesj	728	6	be	be	VB
cord-000248-zueoyesj	728	7	part	part	NN
cord-000248-zueoyesj	728	8	of	of	IN
cord-000248-zueoyesj	728	9	the	the	DT
cord-000248-zueoyesj	728	10	set	set	NN
cord-000248-zueoyesj	728	11	of	of	IN
cord-000248-zueoyesj	728	12	revesible	revesible	JJ
cord-000248-zueoyesj	728	13	processes	process	NNS
cord-000248-zueoyesj	728	14	that	that	WDT
cord-000248-zueoyesj	728	15	could	could	MD
cord-000248-zueoyesj	728	16	occur	occur	VB
cord-000248-zueoyesj	728	17	in	in	IN
cord-000248-zueoyesj	728	18	a	a	DT
cord-000248-zueoyesj	728	19	cancer	cancer	NN
cord-000248-zueoyesj	728	20	cell	cell	NN
cord-000248-zueoyesj	728	21	,	,	,
cord-000248-zueoyesj	728	22	while	while	IN
cord-000248-zueoyesj	728	23	other	other	JJ
cord-000248-zueoyesj	728	24	processes	process	NNS
cord-000248-zueoyesj	728	25	like	like	IN
cord-000248-zueoyesj	728	26	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	728	27	or	or	CC
cord-000248-zueoyesj	728	28	gene	gene	NN
cord-000248-zueoyesj	728	29	fusions	fusion	NNS
cord-000248-zueoyesj	728	30	could	could	MD
cord-000248-zueoyesj	728	31	be	be	VB
cord-000248-zueoyesj	728	32	truly	truly	RB
cord-000248-zueoyesj	728	33	'	'	``
cord-000248-zueoyesj	728	34	'	'	``
cord-000248-zueoyesj	728	35	irreversible	irreversible	JJ
cord-000248-zueoyesj	728	36	genetic	genetic	JJ
cord-000248-zueoyesj	728	37	switches	switch	NNS
cord-000248-zueoyesj	728	38	'	'	POS
cord-000248-zueoyesj	728	39	'	'	''
cord-000248-zueoyesj	728	40	associated	associate	VBN
cord-000248-zueoyesj	728	41	with	with	IN
cord-000248-zueoyesj	728	42	cancer	cancer	NN
cord-000248-zueoyesj	728	43	progression	progression	NN
cord-000248-zueoyesj	728	44	[	[	-LRB-
cord-000248-zueoyesj	728	45	628	628	CD
cord-000248-zueoyesj	728	46	]	]	-RRB-
cord-000248-zueoyesj	728	47	.	.	.
cord-000248-zueoyesj	729	1	If	if	IN
cord-000248-zueoyesj	729	2	we	-PRON-	PRP
cord-000248-zueoyesj	729	3	assume	assume	VBP
cord-000248-zueoyesj	729	4	that	that	IN
cord-000248-zueoyesj	729	5	the	the	DT
cord-000248-zueoyesj	729	6	process	process	NN
cord-000248-zueoyesj	729	7	is	be	VBZ
cord-000248-zueoyesj	729	8	slow	slow	JJ
cord-000248-zueoyesj	729	9	(	(	-LRB-
cord-000248-zueoyesj	729	10	i.e.	i.e.	FW
cord-000248-zueoyesj	729	11	the	the	DT
cord-000248-zueoyesj	729	12	times	time	NNS
cord-000248-zueoyesj	729	13	required	require	VBN
cord-000248-zueoyesj	729	14	for	for	IN
cord-000248-zueoyesj	729	15	significant	significant	JJ
cord-000248-zueoyesj	729	16	variations	variation	NNS
cord-000248-zueoyesj	729	17	of	of	IN
cord-000248-zueoyesj	729	18	the	the	DT
cord-000248-zueoyesj	729	19	transcriptome	transcriptome	NN
cord-000248-zueoyesj	729	20	's	's	POS
cord-000248-zueoyesj	729	21	profile	profile	NN
cord-000248-zueoyesj	729	22	is	be	VBZ
cord-000248-zueoyesj	729	23	large	large	JJ
cord-000248-zueoyesj	729	24	in	in	IN
cord-000248-zueoyesj	729	25	comparison	comparison	NN
cord-000248-zueoyesj	729	26	with	with	IN
cord-000248-zueoyesj	729	27	the	the	DT
cord-000248-zueoyesj	729	28	cell	cell	NN
cord-000248-zueoyesj	729	29	's	's	POS
cord-000248-zueoyesj	729	30	processes	process	NNS
cord-000248-zueoyesj	729	31	time	time	NN
cord-000248-zueoyesj	729	32	scales	scale	NNS
cord-000248-zueoyesj	729	33	)	)	-RRB-
cord-000248-zueoyesj	729	34	,	,	,
cord-000248-zueoyesj	729	35	and	and	CC
cord-000248-zueoyesj	729	36	follwing	follwe	VBG
cord-000248-zueoyesj	729	37	the	the	DT
cord-000248-zueoyesj	729	38	results	result	NNS
cord-000248-zueoyesj	729	39	of	of	IN
cord-000248-zueoyesj	729	40	Spirkl	Spirkl	NNP
cord-000248-zueoyesj	729	41	and	and	CC
cord-000248-zueoyesj	729	42	Reis	Reis	NNP
cord-000248-zueoyesj	729	43	[	[	-LRB-
cord-000248-zueoyesj	729	44	626	626	CD
cord-000248-zueoyesj	729	45	]	]	-RRB-
cord-000248-zueoyesj	729	46	,	,	,
cord-000248-zueoyesj	729	47	it	-PRON-	PRP
cord-000248-zueoyesj	729	48	may	may	MD
cord-000248-zueoyesj	729	49	be	be	VB
cord-000248-zueoyesj	729	50	possible	possible	JJ
cord-000248-zueoyesj	729	51	that	that	IN
cord-000248-zueoyesj	729	52	we	-PRON-	PRP
cord-000248-zueoyesj	729	53	have	have	VBP
cord-000248-zueoyesj	729	54	a	a	DT
cord-000248-zueoyesj	729	55	constant	constant	JJ
cord-000248-zueoyesj	729	56	entropy	entropy	NN
cord-000248-zueoyesj	729	57	production	production	NN
cord-000248-zueoyesj	729	58	rate	rate	NN
cord-000248-zueoyesj	729	59	exists	exist	VBZ
cord-000248-zueoyesj	729	60	during	during	IN
cord-000248-zueoyesj	729	61	cancer	cancer	NN
cord-000248-zueoyesj	729	62	progression	progression	NN
cord-000248-zueoyesj	729	63	leading	lead	VBG
cord-000248-zueoyesj	729	64	to	to	IN
cord-000248-zueoyesj	729	65	Hauptmann	Hauptmann	NNP
cord-000248-zueoyesj	729	66	's	's	POS
cord-000248-zueoyesj	729	67	'	'	``
cord-000248-zueoyesj	729	68	'	'	``
cord-000248-zueoyesj	729	69	entropic	entropic	JJ
cord-000248-zueoyesj	729	70	devolution	devolution	NN
cord-000248-zueoyesj	729	71	'	'	''
cord-000248-zueoyesj	729	72	'	'	''
cord-000248-zueoyesj	729	73	[	[	-LRB-
cord-000248-zueoyesj	729	74	629	629	CD
cord-000248-zueoyesj	729	75	]	]	-RRB-
cord-000248-zueoyesj	729	76	.	.	.
cord-000248-zueoyesj	730	1	Hauptmann	Hauptmann	NNP
cord-000248-zueoyesj	730	2	sees	see	VBZ
cord-000248-zueoyesj	730	3	a	a	DT
cord-000248-zueoyesj	730	4	malignant	malignant	JJ
cord-000248-zueoyesj	730	5	tumour	tumour	NN
cord-000248-zueoyesj	730	6	as	as	IN
cord-000248-zueoyesj	730	7	'	'	''
cord-000248-zueoyesj	730	8	'	'	''
cord-000248-zueoyesj	730	9	a	a	DT
cord-000248-zueoyesj	730	10	dissipative	dissipative	JJ
cord-000248-zueoyesj	730	11	structure	structure	NN
cord-000248-zueoyesj	730	12	arising	arise	VBG
cord-000248-zueoyesj	730	13	within	within	IN
cord-000248-zueoyesj	730	14	the	the	DT
cord-000248-zueoyesj	730	15	thermodynamical	thermodynamical	JJ
cord-000248-zueoyesj	730	16	open	open	JJ
cord-000248-zueoyesj	730	17	system	system	NN
cord-000248-zueoyesj	730	18	of	of	IN
cord-000248-zueoyesj	730	19	the	the	DT
cord-000248-zueoyesj	730	20	human	human	JJ
cord-000248-zueoyesj	730	21	body	body	NN
cord-000248-zueoyesj	730	22	'	'	''
cord-000248-zueoyesj	730	23	'	'	''
cord-000248-zueoyesj	730	24	that	that	WDT
cord-000248-zueoyesj	730	25	starts	start	VBZ
cord-000248-zueoyesj	730	26	when	when	WRB
cord-000248-zueoyesj	730	27	'	'	''
cord-000248-zueoyesj	730	28	'	'	''
cord-000248-zueoyesj	730	29	a	a	DT
cord-000248-zueoyesj	730	30	localized	localized	JJ
cord-000248-zueoyesj	730	31	surplus	surplus	NN
cord-000248-zueoyesj	730	32	of	of	IN
cord-000248-zueoyesj	730	33	energy	energy	NN
cord-000248-zueoyesj	730	34	exists	exist	VBZ
cord-000248-zueoyesj	730	35	and	and	CC
cord-000248-zueoyesj	730	36	there	there	EX
cord-000248-zueoyesj	730	37	is	be	VBZ
cord-000248-zueoyesj	730	38	no	no	DT
cord-000248-zueoyesj	730	39	possibility	possibility	NN
cord-000248-zueoyesj	730	40	to	to	TO
cord-000248-zueoyesj	730	41	export	export	NN
cord-000248-zueoyesj	730	42	entropy	entropy	NN
cord-000248-zueoyesj	730	43	.	.	.
cord-000248-zueoyesj	731	1	An	an	DT
cord-000248-zueoyesj	731	2	energetic	energetic	JJ
cord-000248-zueoyesj	731	3	overload	overload	NN
cord-000248-zueoyesj	731	4	in	in	IN
cord-000248-zueoyesj	731	5	most	most	JJS
cord-000248-zueoyesj	731	6	malignant	malignant	JJ
cord-000248-zueoyesj	731	7	cells	cell	NNS
cord-000248-zueoyesj	731	8	is	be	VBZ
cord-000248-zueoyesj	731	9	indicated	indicate	VBN
cord-000248-zueoyesj	731	10	by	by	IN
cord-000248-zueoyesj	731	11	their	-PRON-	PRP$
cord-000248-zueoyesj	731	12	abnormally	abnormally	RB
cord-000248-zueoyesj	731	13	high	high	JJ
cord-000248-zueoyesj	731	14	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	731	15	state	state	NN
cord-000248-zueoyesj	731	16	.	.	.
cord-000248-zueoyesj	731	17	'	'	''
cord-000248-zueoyesj	731	18	'	'	''
cord-000248-zueoyesj	732	1	His	-PRON-	PRP$
cord-000248-zueoyesj	732	2	perspective	perspective	NN
cord-000248-zueoyesj	732	3	,	,	,
cord-000248-zueoyesj	732	4	preceeded	preceede	VBN
cord-000248-zueoyesj	732	5	in	in	IN
cord-000248-zueoyesj	732	6	part	part	NN
cord-000248-zueoyesj	732	7	by	by	IN
cord-000248-zueoyesj	732	8	Dimitrov	Dimitrov	NNP
cord-000248-zueoyesj	732	9	[	[	-LRB-
cord-000248-zueoyesj	732	10	630	630	CD
cord-000248-zueoyesj	732	11	]	]	-RRB-
cord-000248-zueoyesj	732	12	,	,	,
cord-000248-zueoyesj	732	13	Klimek	Klimek	NNP
cord-000248-zueoyesj	732	14	[	[	-LRB-
cord-000248-zueoyesj	732	15	631	631	CD
cord-000248-zueoyesj	732	16	,	,	,
cord-000248-zueoyesj	732	17	632	632	CD
cord-000248-zueoyesj	732	18	]	]	-RRB-
cord-000248-zueoyesj	732	19	and	and	CC
cord-000248-zueoyesj	732	20	Marinescu	Marinescu	NNP
cord-000248-zueoyesj	732	21	and	and	CC
cord-000248-zueoyesj	732	22	Viculetz	Viculetz	NNP
cord-000248-zueoyesj	732	23	[	[	-LRB-
cord-000248-zueoyesj	732	24	633	633	CD
cord-000248-zueoyesj	732	25	]	]	-RRB-
cord-000248-zueoyesj	732	26	might	may	MD
cord-000248-zueoyesj	732	27	then	then	RB
cord-000248-zueoyesj	732	28	fit	fit	VB
cord-000248-zueoyesj	732	29	well	well	RB
cord-000248-zueoyesj	732	30	an	an	DT
cord-000248-zueoyesj	732	31	endoreversible	endoreversible	JJ
cord-000248-zueoyesj	732	32	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	732	33	formalism	formalism	NN
cord-000248-zueoyesj	732	34	.	.	.
cord-000248-zueoyesj	733	1	Hauptmann	Hauptmann	NNP
cord-000248-zueoyesj	733	2	says	say	VBZ
cord-000248-zueoyesj	733	3	in	in	IN
cord-000248-zueoyesj	733	4	[	[	-LRB-
cord-000248-zueoyesj	733	5	629	629	CD
cord-000248-zueoyesj	733	6	]	]	-RRB-
cord-000248-zueoyesj	733	7	''	''	''
cord-000248-zueoyesj	734	1	I	-PRON-	PRP
cord-000248-zueoyesj	734	2	believe	believe	VBP
cord-000248-zueoyesj	734	3	that	that	IN
cord-000248-zueoyesj	734	4	cancer	cancer	NN
cord-000248-zueoyesj	734	5	is	be	VBZ
cord-000248-zueoyesj	734	6	a	a	DT
cord-000248-zueoyesj	734	7	special	special	JJ
cord-000248-zueoyesj	734	8	kind	kind	NN
cord-000248-zueoyesj	734	9	of	of	IN
cord-000248-zueoyesj	734	10	adaptation	adaptation	NN
cord-000248-zueoyesj	734	11	to	to	IN
cord-000248-zueoyesj	734	12	energetic	energetic	JJ
cord-000248-zueoyesj	734	13	overload	overload	NN
cord-000248-zueoyesj	734	14	,	,	,
cord-000248-zueoyesj	734	15	characterized	characterize	VBN
cord-000248-zueoyesj	734	16	by	by	IN
cord-000248-zueoyesj	734	17	multiplication	multiplication	NN
cord-000248-zueoyesj	734	18	and	and	CC
cord-000248-zueoyesj	734	19	mutation	mutation	NN
cord-000248-zueoyesj	734	20	of	of	IN
cord-000248-zueoyesj	734	21	genomic	genomic	JJ
cord-000248-zueoyesj	734	22	DNA	dna	NN
cord-000248-zueoyesj	734	23	(	(	-LRB-
cord-000248-zueoyesj	734	24	generation	generation	NN
cord-000248-zueoyesj	734	25	of	of	IN
cord-000248-zueoyesj	734	26	new	new	JJ
cord-000248-zueoyesj	734	27	biomolecules	biomolecule	NNS
cord-000248-zueoyesj	734	28	which	which	WDT
cord-000248-zueoyesj	734	29	enhance	enhance	VBP
cord-000248-zueoyesj	734	30	the	the	DT
cord-000248-zueoyesj	734	31	probability	probability	NN
cord-000248-zueoyesj	734	32	of	of	IN
cord-000248-zueoyesj	734	33	survival	survival	NN
cord-000248-zueoyesj	734	34	under	under	IN
cord-000248-zueoyesj	734	35	harmful	harmful	JJ
cord-000248-zueoyesj	734	36	conditions	condition	NNS
cord-000248-zueoyesj	734	37	)	)	-RRB-
cord-000248-zueoyesj	734	38	,	,	,
cord-000248-zueoyesj	734	39	and	and	CC
cord-000248-zueoyesj	734	40	by	by	IN
cord-000248-zueoyesj	734	41	chiral	chiral	JJ
cord-000248-zueoyesj	734	42	alterations	alteration	NNS
cord-000248-zueoyesj	734	43	(	(	-LRB-
cord-000248-zueoyesj	734	44	reduction	reduction	NN
cord-000248-zueoyesj	734	45	of	of	IN
cord-000248-zueoyesj	734	46	entropy	entropy	NN
cord-000248-zueoyesj	734	47	by	by	IN
cord-000248-zueoyesj	734	48	entrapping	entrap	VBG
cord-000248-zueoyesj	734	49	energy	energy	NN
cord-000248-zueoyesj	734	50	)	)	-RRB-
cord-000248-zueoyesj	734	51	leading	lead	VBG
cord-000248-zueoyesj	734	52	to	to	IN
cord-000248-zueoyesj	734	53	abnormal	abnormal	JJ
cord-000248-zueoyesj	734	54	configurated	configurated	JJ
cord-000248-zueoyesj	734	55	biomolecules	biomolecule	NNS
cord-000248-zueoyesj	734	56	.	.	.
cord-000248-zueoyesj	735	1	In	in	IN
cord-000248-zueoyesj	735	2	this	this	DT
cord-000248-zueoyesj	735	3	regard	regard	NN
cord-000248-zueoyesj	735	4	the	the	DT
cord-000248-zueoyesj	735	5	genetic	genetic	JJ
cord-000248-zueoyesj	735	6	alterations	alteration	NNS
cord-000248-zueoyesj	735	7	are	be	VBP
cord-000248-zueoyesj	735	8	probably	probably	RB
cord-000248-zueoyesj	735	9	secondary	secondary	JJ
cord-000248-zueoyesj	735	10	changes	change	NNS
cord-000248-zueoyesj	735	11	.	.	.
cord-000248-zueoyesj	736	1	Cancer	cancer	NN
cord-000248-zueoyesj	736	2	serves	serve	VBZ
cord-000248-zueoyesj	736	3	to	to	TO
cord-000248-zueoyesj	736	4	dissipate	dissipate	VB
cord-000248-zueoyesj	736	5	energy	energy	NN
cord-000248-zueoyesj	736	6	in	in	IN
cord-000248-zueoyesj	736	7	a	a	DT
cord-000248-zueoyesj	736	8	type	type	NN
cord-000248-zueoyesj	736	9	of	of	IN
cord-000248-zueoyesj	736	10	developmental	developmental	JJ
cord-000248-zueoyesj	736	11	process	process	NN
cord-000248-zueoyesj	736	12	but	but	CC
cord-000248-zueoyesj	736	13	one	one	CD
cord-000248-zueoyesj	736	14	in	in	IN
cord-000248-zueoyesj	736	15	which	which	WDT
cord-000248-zueoyesj	736	16	the	the	DT
cord-000248-zueoyesj	736	17	results	result	NNS
cord-000248-zueoyesj	736	18	are	be	VBP
cord-000248-zueoyesj	736	19	harmful	harmful	JJ
cord-000248-zueoyesj	736	20	to	to	IN
cord-000248-zueoyesj	736	21	the	the	DT
cord-000248-zueoyesj	736	22	whole	whole	JJ
cord-000248-zueoyesj	736	23	organism	organism	NN
cord-000248-zueoyesj	736	24	:	:	:
cord-000248-zueoyesj	736	25	an	an	DT
cord-000248-zueoyesj	736	26	entropic	entropic	JJ
cord-000248-zueoyesj	736	27	devolution	devolution	NN
cord-000248-zueoyesj	736	28	.	.	.
cord-000248-zueoyesj	736	29	'	'	''
cord-000248-zueoyesj	736	30	'	'	''
cord-000248-zueoyesj	737	1	This	this	DT
cord-000248-zueoyesj	737	2	thermodynamical	thermodynamical	JJ
cord-000248-zueoyesj	737	3	perspective	perspective	NN
cord-000248-zueoyesj	737	4	is	be	VBZ
cord-000248-zueoyesj	737	5	now	now	RB
cord-000248-zueoyesj	737	6	worth	worth	JJ
cord-000248-zueoyesj	737	7	exploring	explore	VBG
cord-000248-zueoyesj	737	8	and	and	CC
cord-000248-zueoyesj	737	9	we	-PRON-	PRP
cord-000248-zueoyesj	737	10	will	will	MD
cord-000248-zueoyesj	737	11	discuss	discuss	VB
cord-000248-zueoyesj	737	12	it	-PRON-	PRP
cord-000248-zueoyesj	737	13	in	in	IN
cord-000248-zueoyesj	737	14	this	this	DT
cord-000248-zueoyesj	737	15	context	context	NN
cord-000248-zueoyesj	737	16	.	.	.
cord-000248-zueoyesj	738	1	Assuming	assume	VBG
cord-000248-zueoyesj	738	2	that	that	IN
cord-000248-zueoyesj	738	3	a	a	DT
cord-000248-zueoyesj	738	4	cancer	cancer	NN
cord-000248-zueoyesj	738	5	cell	cell	NN
cord-000248-zueoyesj	738	6	is	be	VBZ
cord-000248-zueoyesj	738	7	in	in	IN
cord-000248-zueoyesj	738	8	a	a	DT
cord-000248-zueoyesj	738	9	state	state	NN
cord-000248-zueoyesj	738	10	of	of	IN
cord-000248-zueoyesj	738	11	'	'	``
cord-000248-zueoyesj	738	12	'	'	``
cord-000248-zueoyesj	738	13	energy	energy	NN
cord-000248-zueoyesj	738	14	overload	overload	NN
cord-000248-zueoyesj	738	15	'	'	''
cord-000248-zueoyesj	738	16	'	'	''
cord-000248-zueoyesj	738	17	,	,	,
cord-000248-zueoyesj	738	18	without	without	IN
cord-000248-zueoyesj	738	19	''	''	''
cord-000248-zueoyesj	739	1	the	the	DT
cord-000248-zueoyesj	739	2	possibility	possibility	NN
cord-000248-zueoyesj	739	3	of	of	IN
cord-000248-zueoyesj	739	4	exporting	export	VBG
cord-000248-zueoyesj	739	5	entropy	entropy	NN
cord-000248-zueoyesj	739	6	'	'	''
cord-000248-zueoyesj	739	7	'	'	''
cord-000248-zueoyesj	739	8	,	,	,
cord-000248-zueoyesj	739	9	could	could	MD
cord-000248-zueoyesj	739	10	it	-PRON-	PRP
cord-000248-zueoyesj	739	11	lead	lead	VB
cord-000248-zueoyesj	739	12	to	to	IN
cord-000248-zueoyesj	739	13	some	some	DT
cord-000248-zueoyesj	739	14	type	type	NN
cord-000248-zueoyesj	739	15	of	of	IN
cord-000248-zueoyesj	739	16	'	'	''
cord-000248-zueoyesj	739	17	'	'	``
cord-000248-zueoyesj	739	18	genetic	genetic	JJ
cord-000248-zueoyesj	739	19	alterations	alteration	NNS
cord-000248-zueoyesj	739	20	'	'	''
cord-000248-zueoyesj	739	21	'	'	''
cord-000248-zueoyesj	739	22	?	?	.
cord-000248-zueoyesj	740	1	Which	which	WDT
cord-000248-zueoyesj	740	2	key	key	NN
cord-000248-zueoyesj	740	3	mechanisms	mechanism	NNS
cord-000248-zueoyesj	740	4	might	may	MD
cord-000248-zueoyesj	740	5	be	be	VB
cord-000248-zueoyesj	740	6	impaired	impair	VBN
cord-000248-zueoyesj	740	7	?	?	.
cord-000248-zueoyesj	741	1	What	what	WDT
cord-000248-zueoyesj	741	2	consequences	consequence	NNS
cord-000248-zueoyesj	741	3	is	be	VBZ
cord-000248-zueoyesj	741	4	this	this	DT
cord-000248-zueoyesj	741	5	'	'	``
cord-000248-zueoyesj	741	6	'	'	``
cord-000248-zueoyesj	741	7	system	system	NN
cord-000248-zueoyesj	741	8	'	'	''
cord-000248-zueoyesj	741	9	'	'	''
cord-000248-zueoyesj	741	10	delivering	delivering	NN
cord-000248-zueoyesj	741	11	?	?	.
cord-000248-zueoyesj	742	1	Could	Could	MD
cord-000248-zueoyesj	742	2	this	this	DT
cord-000248-zueoyesj	742	3	be	be	VB
cord-000248-zueoyesj	742	4	another	another	DT
cord-000248-zueoyesj	742	5	hallmark	hallmark	NN
cord-000248-zueoyesj	742	6	for	for	IN
cord-000248-zueoyesj	742	7	oncosystems	oncosystem	NNS
cord-000248-zueoyesj	742	8	indentification	indentification	NNP
cord-000248-zueoyesj	742	9	?	?	.
cord-000248-zueoyesj	743	1	In	in	IN
cord-000248-zueoyesj	743	2	1871	1871	CD
cord-000248-zueoyesj	743	3	,	,	,
cord-000248-zueoyesj	743	4	in	in	IN
cord-000248-zueoyesj	743	5	this	this	DT
cord-000248-zueoyesj	743	6	book	book	NN
cord-000248-zueoyesj	743	7	called	call	VBD
cord-000248-zueoyesj	743	8	'	'	''
cord-000248-zueoyesj	743	9	'	'	''
cord-000248-zueoyesj	743	10	Theory	Theory	NNP
cord-000248-zueoyesj	743	11	of	of	IN
cord-000248-zueoyesj	743	12	Heat	Heat	NNP
cord-000248-zueoyesj	743	13	'	'	''
cord-000248-zueoyesj	743	14	'	'	''
cord-000248-zueoyesj	743	15	,	,	,
cord-000248-zueoyesj	743	16	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	743	17	speculated	speculate	VBD
cord-000248-zueoyesj	743	18	the	the	DT
cord-000248-zueoyesj	743	19	idea	idea	NN
cord-000248-zueoyesj	743	20	of	of	IN
cord-000248-zueoyesj	743	21	'	'	``
cord-000248-zueoyesj	743	22	'	'	''
cord-000248-zueoyesj	743	23	a	a	DT
cord-000248-zueoyesj	743	24	being	being	NN
cord-000248-zueoyesj	743	25	,	,	,
cord-000248-zueoyesj	743	26	who	who	WP
cord-000248-zueoyesj	743	27	can	can	MD
cord-000248-zueoyesj	743	28	see	see	VB
cord-000248-zueoyesj	743	29	the	the	DT
cord-000248-zueoyesj	743	30	individual	individual	JJ
cord-000248-zueoyesj	743	31	molecules	molecule	NNS
cord-000248-zueoyesj	743	32	'	'	''
cord-000248-zueoyesj	743	33	'	'	''
cord-000248-zueoyesj	743	34	and	and	CC
cord-000248-zueoyesj	743	35	who	who	WP
cord-000248-zueoyesj	743	36	has	have	VBZ
cord-000248-zueoyesj	743	37	enough	enough	JJ
cord-000248-zueoyesj	743	38	reactive	reactive	JJ
cord-000248-zueoyesj	743	39	intelligence	intelligence	NN
cord-000248-zueoyesj	743	40	to	to	TO
cord-000248-zueoyesj	743	41	open	open	VB
cord-000248-zueoyesj	743	42	and	and	CC
cord-000248-zueoyesj	743	43	close	close	VB
cord-000248-zueoyesj	743	44	a	a	DT
cord-000248-zueoyesj	743	45	unique	unique	JJ
cord-000248-zueoyesj	743	46	small	small	JJ
cord-000248-zueoyesj	743	47	hole	hole	NN
cord-000248-zueoyesj	743	48	existing	exist	VBG
cord-000248-zueoyesj	743	49	between	between	IN
cord-000248-zueoyesj	743	50	two	two	CD
cord-000248-zueoyesj	743	51	communicating	communicate	VBG
cord-000248-zueoyesj	743	52	vessels	vessel	NNS
cord-000248-zueoyesj	743	53	(	(	-LRB-
cord-000248-zueoyesj	743	54	called	call	VBN
cord-000248-zueoyesj	743	55	'	'	``
cord-000248-zueoyesj	743	56	A	a	NN
cord-000248-zueoyesj	743	57	'	'	''
cord-000248-zueoyesj	743	58	and	and	CC
cord-000248-zueoyesj	743	59	'	'	``
cord-000248-zueoyesj	743	60	B	b	NN
cord-000248-zueoyesj	743	61	'	'	''
cord-000248-zueoyesj	743	62	)	)	-RRB-
cord-000248-zueoyesj	743	63	.	.	.
cord-000248-zueoyesj	744	1	An	an	DT
cord-000248-zueoyesj	744	2	ideal	ideal	JJ
cord-000248-zueoyesj	744	3	gas	gas	NN
cord-000248-zueoyesj	744	4	filled	fill	VBD
cord-000248-zueoyesj	744	5	both	both	DT
cord-000248-zueoyesj	744	6	vessels	vessel	NNS
cord-000248-zueoyesj	744	7	,	,	,
cord-000248-zueoyesj	744	8	so	so	IN
cord-000248-zueoyesj	744	9	that	that	IN
cord-000248-zueoyesj	744	10	starting	start	VBG
cord-000248-zueoyesj	744	11	at	at	IN
cord-000248-zueoyesj	744	12	uniform	uniform	JJ
cord-000248-zueoyesj	744	13	temperature	temperature	NN
cord-000248-zueoyesj	744	14	the	the	DT
cord-000248-zueoyesj	744	15	intelligent	intelligent	JJ
cord-000248-zueoyesj	744	16	being	being	NN
cord-000248-zueoyesj	744	17	could	could	MD
cord-000248-zueoyesj	744	18	observe	observe	VB
cord-000248-zueoyesj	744	19	the	the	DT
cord-000248-zueoyesj	744	20	molecules	molecule	NNS
cord-000248-zueoyesj	744	21	and	and	CC
cord-000248-zueoyesj	744	22	close	close	VB
cord-000248-zueoyesj	744	23	and	and	CC
cord-000248-zueoyesj	744	24	open	open	VB
cord-000248-zueoyesj	744	25	the	the	DT
cord-000248-zueoyesj	744	26	hole	hole	NN
cord-000248-zueoyesj	744	27	accordingly	accordingly	RB
cord-000248-zueoyesj	744	28	to	to	IN
cord-000248-zueoyesj	744	29	a	a	DT
cord-000248-zueoyesj	744	30	mission	mission	NN
cord-000248-zueoyesj	744	31	:	:	:
cord-000248-zueoyesj	744	32	'	'	''
cord-000248-zueoyesj	744	33	'	'	''
cord-000248-zueoyesj	744	34	to	to	TO
cord-000248-zueoyesj	744	35	allow	allow	VB
cord-000248-zueoyesj	744	36	only	only	RB
cord-000248-zueoyesj	744	37	the	the	DT
cord-000248-zueoyesj	744	38	swifter	swift	JJR
cord-000248-zueoyesj	744	39	molecules	molecule	NNS
cord-000248-zueoyesj	744	40	to	to	TO
cord-000248-zueoyesj	744	41	pass	pass	VB
cord-000248-zueoyesj	744	42	from	from	IN
cord-000248-zueoyesj	744	43	A	a	NN
cord-000248-zueoyesj	744	44	to	to	IN
cord-000248-zueoyesj	744	45	B	b	NN
cord-000248-zueoyesj	744	46	,	,	,
cord-000248-zueoyesj	744	47	and	and	CC
cord-000248-zueoyesj	744	48	only	only	RB
cord-000248-zueoyesj	744	49	the	the	DT
cord-000248-zueoyesj	744	50	slower	slow	JJR
cord-000248-zueoyesj	744	51	ones	one	NNS
cord-000248-zueoyesj	744	52	pass	pass	VBP
cord-000248-zueoyesj	744	53	from	from	IN
cord-000248-zueoyesj	744	54	B	b	NN
cord-000248-zueoyesj	744	55	to	to	IN
cord-000248-zueoyesj	744	56	A.	a.	NN
cord-000248-zueoyesj	744	57	'	'	''
cord-000248-zueoyesj	744	58	'	'	''
cord-000248-zueoyesj	745	1	The	the	DT
cord-000248-zueoyesj	745	2	being	being	NN
cord-000248-zueoyesj	745	3	,	,	,
cord-000248-zueoyesj	745	4	'	'	''
cord-000248-zueoyesj	745	5	'	'	''
cord-000248-zueoyesj	745	6	without	without	IN
cord-000248-zueoyesj	745	7	expenditure	expenditure	NN
cord-000248-zueoyesj	745	8	of	of	IN
cord-000248-zueoyesj	745	9	work	work	NN
cord-000248-zueoyesj	745	10	raise	raise	VBP
cord-000248-zueoyesj	745	11	the	the	DT
cord-000248-zueoyesj	745	12	temperature	temperature	NN
cord-000248-zueoyesj	745	13	of	of	IN
cord-000248-zueoyesj	745	14	B	b	NN
cord-000248-zueoyesj	745	15	and	and	CC
cord-000248-zueoyesj	745	16	lower	lower	VB
cord-000248-zueoyesj	745	17	that	that	DT
cord-000248-zueoyesj	745	18	of	of	IN
cord-000248-zueoyesj	745	19	A	a	DT
cord-000248-zueoyesj	745	20	in	in	IN
cord-000248-zueoyesj	745	21	contradiction	contradiction	NN
cord-000248-zueoyesj	745	22	to	to	IN
cord-000248-zueoyesj	745	23	the	the	DT
cord-000248-zueoyesj	745	24	second	second	JJ
cord-000248-zueoyesj	745	25	law	law	NN
cord-000248-zueoyesj	745	26	of	of	IN
cord-000248-zueoyesj	745	27	thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	745	28	.	.	.
cord-000248-zueoyesj	745	29	'	'	''
cord-000248-zueoyesj	746	1	'	'	''
cord-000248-zueoyesj	747	1	The	the	DT
cord-000248-zueoyesj	747	2	ability	ability	NN
cord-000248-zueoyesj	747	3	of	of	IN
cord-000248-zueoyesj	747	4	the	the	DT
cord-000248-zueoyesj	747	5	'	'	``
cord-000248-zueoyesj	747	6	'	'	''
cord-000248-zueoyesj	747	7	being	be	VBG
cord-000248-zueoyesj	747	8	'	'	''
cord-000248-zueoyesj	747	9	'	'	''
cord-000248-zueoyesj	747	10	to	to	TO
cord-000248-zueoyesj	747	11	use	use	VB
cord-000248-zueoyesj	747	12	observable	observable	JJ
cord-000248-zueoyesj	747	13	information	information	NN
cord-000248-zueoyesj	747	14	about	about	IN
cord-000248-zueoyesj	747	15	the	the	DT
cord-000248-zueoyesj	747	16	system	system	NN
cord-000248-zueoyesj	747	17	to	to	TO
cord-000248-zueoyesj	747	18	lower	lower	VB
cord-000248-zueoyesj	747	19	the	the	DT
cord-000248-zueoyesj	747	20	thermodynamical	thermodynamical	JJ
cord-000248-zueoyesj	747	21	entropy	entropy	NN
cord-000248-zueoyesj	747	22	has	have	VBZ
cord-000248-zueoyesj	747	23	motivated	motivate	VBN
cord-000248-zueoyesj	747	24	many	many	JJ
cord-000248-zueoyesj	747	25	articles	article	NNS
cord-000248-zueoyesj	747	26	in	in	IN
cord-000248-zueoyesj	747	27	physics	physics	NN
cord-000248-zueoyesj	747	28	and	and	CC
cord-000248-zueoyesj	747	29	fuelled	fuel	VBD
cord-000248-zueoyesj	747	30	the	the	DT
cord-000248-zueoyesj	747	31	imagination	imagination	NN
cord-000248-zueoyesj	747	32	of	of	IN
cord-000248-zueoyesj	747	33	many	many	JJ
cord-000248-zueoyesj	747	34	since	since	IN
cord-000248-zueoyesj	747	35	it	-PRON-	PRP
cord-000248-zueoyesj	747	36	was	be	VBD
cord-000248-zueoyesj	747	37	originally	originally	RB
cord-000248-zueoyesj	747	38	introduced	introduce	VBN
cord-000248-zueoyesj	747	39	by	by	IN
cord-000248-zueoyesj	747	40	Mawell	Mawell	NNP
cord-000248-zueoyesj	747	41	,	,	,
cord-000248-zueoyesj	747	42	and	and	CC
cord-000248-zueoyesj	747	43	named	name	VBN
cord-000248-zueoyesj	747	44	as	as	IN
cord-000248-zueoyesj	747	45	'	'	``
cord-000248-zueoyesj	747	46	'	'	``
cord-000248-zueoyesj	747	47	demon	demon	NN
cord-000248-zueoyesj	747	48	'	'	''
cord-000248-zueoyesj	747	49	'	'	''
cord-000248-zueoyesj	747	50	by	by	IN
cord-000248-zueoyesj	747	51	Thomson	Thomson	NNP
cord-000248-zueoyesj	747	52	three	three	CD
cord-000248-zueoyesj	747	53	years	year	NNS
cord-000248-zueoyesj	747	54	later	later	RB
cord-000248-zueoyesj	747	55	[	[	-LRB-
cord-000248-zueoyesj	747	56	622	622	CD
cord-000248-zueoyesj	747	57	]	]	-RRB-
cord-000248-zueoyesj	747	58	.	.	.
cord-000248-zueoyesj	748	1	An	an	DT
cord-000248-zueoyesj	748	2	excellent	excellent	JJ
cord-000248-zueoyesj	748	3	collection	collection	NN
cord-000248-zueoyesj	748	4	of	of	IN
cord-000248-zueoyesj	748	5	articles	article	NNS
cord-000248-zueoyesj	748	6	until	until	IN
cord-000248-zueoyesj	748	7	1990	1990	CD
cord-000248-zueoyesj	748	8	[	[	-LRB-
cord-000248-zueoyesj	748	9	634	634	CD
cord-000248-zueoyesj	748	10	,	,	,
cord-000248-zueoyesj	748	11	635	635	CD
cord-000248-zueoyesj	748	12	,	,	,
cord-000248-zueoyesj	748	13	636	636	CD
cord-000248-zueoyesj	748	14	,	,	,
cord-000248-zueoyesj	748	15	637	637	CD
cord-000248-zueoyesj	748	16	,	,	,
cord-000248-zueoyesj	748	17	638	638	CD
cord-000248-zueoyesj	748	18	,	,	,
cord-000248-zueoyesj	748	19	639	639	CD
cord-000248-zueoyesj	748	20	,	,	,
cord-000248-zueoyesj	748	21	640	640	CD
cord-000248-zueoyesj	748	22	,	,	,
cord-000248-zueoyesj	748	23	641	641	CD
cord-000248-zueoyesj	748	24	,	,	,
cord-000248-zueoyesj	748	25	642	642	CD
cord-000248-zueoyesj	748	26	,	,	,
cord-000248-zueoyesj	748	27	643	643	CD
cord-000248-zueoyesj	748	28	,	,	,
cord-000248-zueoyesj	748	29	644	644	CD
cord-000248-zueoyesj	748	30	]	]	-RRB-
cord-000248-zueoyesj	748	31	was	be	VBD
cord-000248-zueoyesj	748	32	edited	edit	VBN
cord-000248-zueoyesj	748	33	by	by	IN
cord-000248-zueoyesj	748	34	Leff	Leff	NNP
cord-000248-zueoyesj	748	35	and	and	CC
cord-000248-zueoyesj	748	36	Rex	Rex	NNP
cord-000248-zueoyesj	748	37	[	[	-LRB-
cord-000248-zueoyesj	748	38	645	645	CD
cord-000248-zueoyesj	748	39	]	]	-RRB-
cord-000248-zueoyesj	748	40	.	.	.
cord-000248-zueoyesj	749	1	The	the	DT
cord-000248-zueoyesj	749	2	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	749	3	'	'	POS
cord-000248-zueoyesj	749	4	'	'	``
cord-000248-zueoyesj	749	5	demon	demon	NN
cord-000248-zueoyesj	749	6	'	'	''
cord-000248-zueoyesj	749	7	'	'	''
cord-000248-zueoyesj	749	8	,	,	,
cord-000248-zueoyesj	749	9	far	far	RB
cord-000248-zueoyesj	749	10	from	from	IN
cord-000248-zueoyesj	749	11	being	be	VBG
cord-000248-zueoyesj	749	12	'	'	``
cord-000248-zueoyesj	749	13	'	'	``
cord-000248-zueoyesj	749	14	exorcised	exorcise	VBN
cord-000248-zueoyesj	749	15	'	'	''
cord-000248-zueoyesj	749	16	'	'	''
cord-000248-zueoyesj	749	17	from	from	IN
cord-000248-zueoyesj	749	18	Physics	Physics	NNP
cord-000248-zueoyesj	749	19	,	,	,
cord-000248-zueoyesj	749	20	still	still	RB
cord-000248-zueoyesj	749	21	inspires	inspire	VBZ
cord-000248-zueoyesj	749	22	interesting	interesting	JJ
cord-000248-zueoyesj	749	23	new	new	JJ
cord-000248-zueoyesj	749	24	perspectives	perspective	NNS
cord-000248-zueoyesj	749	25	[	[	-LRB-
cord-000248-zueoyesj	749	26	634,635,636,637,638,639,640,641,642,643,644,646,647	634,635,636,637,638,639,640,641,642,643,644,646,647	NNP
cord-000248-zueoyesj	749	27	]	]	-RRB-
cord-000248-zueoyesj	749	28	.	.	.
cord-000248-zueoyesj	750	1	In	in	IN
cord-000248-zueoyesj	750	2	a	a	DT
cord-000248-zueoyesj	750	3	letter	letter	NN
cord-000248-zueoyesj	750	4	to	to	IN
cord-000248-zueoyesj	750	5	Peter	Peter	NNP
cord-000248-zueoyesj	750	6	Guthrie	Guthrie	NNP
cord-000248-zueoyesj	750	7	Tait	Tait	NNP
cord-000248-zueoyesj	750	8	,	,	,
cord-000248-zueoyesj	750	9	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	750	10	writes	write	VBZ
cord-000248-zueoyesj	750	11	about	about	IN
cord-000248-zueoyesj	750	12	the	the	DT
cord-000248-zueoyesj	750	13	'	'	``
cord-000248-zueoyesj	750	14	'	'	``
cord-000248-zueoyesj	750	15	demons	demon	NNS
cord-000248-zueoyesj	750	16	'	'	''
cord-000248-zueoyesj	750	17	'	'	''
cord-000248-zueoyesj	750	18	:	:	:
cord-000248-zueoyesj	750	19	'	'	''
cord-000248-zueoyesj	750	20	'	'	''
cord-000248-zueoyesj	750	21	Is	be	VBZ
cord-000248-zueoyesj	750	22	the	the	DT
cord-000248-zueoyesj	750	23	production	production	NN
cord-000248-zueoyesj	750	24	of	of	IN
cord-000248-zueoyesj	750	25	an	an	DT
cord-000248-zueoyesj	750	26	inequality	inequality	NN
cord-000248-zueoyesj	750	27	of	of	IN
cord-000248-zueoyesj	750	28	temperature	temperature	NN
cord-000248-zueoyesj	750	29	their	-PRON-	PRP$
cord-000248-zueoyesj	750	30	only	only	JJ
cord-000248-zueoyesj	750	31	occupation	occupation	NN
cord-000248-zueoyesj	750	32	?	?	.
cord-000248-zueoyesj	751	1	No	no	UH
cord-000248-zueoyesj	751	2	,	,	,
cord-000248-zueoyesj	751	3	for	for	IN
cord-000248-zueoyesj	751	4	less	less	RBR
cord-000248-zueoyesj	751	5	intelligent	intelligent	JJ
cord-000248-zueoyesj	751	6	demons	demon	NNS
cord-000248-zueoyesj	751	7	can	can	MD
cord-000248-zueoyesj	751	8	produce	produce	VB
cord-000248-zueoyesj	751	9	a	a	DT
cord-000248-zueoyesj	751	10	difference	difference	NN
cord-000248-zueoyesj	751	11	in	in	IN
cord-000248-zueoyesj	751	12	pressure	pressure	NN
cord-000248-zueoyesj	751	13	as	as	RB
cord-000248-zueoyesj	751	14	well	well	RB
cord-000248-zueoyesj	751	15	as	as	IN
cord-000248-zueoyesj	751	16	temperature	temperature	NN
cord-000248-zueoyesj	751	17	by	by	IN
cord-000248-zueoyesj	751	18	merely	merely	RB
cord-000248-zueoyesj	751	19	allowing	allow	VBG
cord-000248-zueoyesj	751	20	all	all	DT
cord-000248-zueoyesj	751	21	particles	particle	NNS
cord-000248-zueoyesj	751	22	going	go	VBG
cord-000248-zueoyesj	751	23	in	in	IN
cord-000248-zueoyesj	751	24	one	one	CD
cord-000248-zueoyesj	751	25	direction	direction	NN
cord-000248-zueoyesj	751	26	while	while	IN
cord-000248-zueoyesj	751	27	stopping	stop	VBG
cord-000248-zueoyesj	751	28	all	all	PDT
cord-000248-zueoyesj	751	29	those	those	DT
cord-000248-zueoyesj	751	30	going	go	VBG
cord-000248-zueoyesj	751	31	the	the	DT
cord-000248-zueoyesj	751	32	other	other	JJ
cord-000248-zueoyesj	751	33	way	way	NN
cord-000248-zueoyesj	751	34	.	.	.
cord-000248-zueoyesj	752	1	This	this	DT
cord-000248-zueoyesj	752	2	reduces	reduce	VBZ
cord-000248-zueoyesj	752	3	the	the	DT
cord-000248-zueoyesj	752	4	demon	demon	NN
cord-000248-zueoyesj	752	5	to	to	IN
cord-000248-zueoyesj	752	6	a	a	DT
cord-000248-zueoyesj	752	7	valve	valve	NN
cord-000248-zueoyesj	752	8	.	.	.
cord-000248-zueoyesj	753	1	As	as	IN
cord-000248-zueoyesj	753	2	such	such	JJ
cord-000248-zueoyesj	753	3	value	value	NN
cord-000248-zueoyesj	753	4	him	-PRON-	PRP
cord-000248-zueoyesj	753	5	.	.	.
cord-000248-zueoyesj	754	1	Call	call	VB
cord-000248-zueoyesj	754	2	him	-PRON-	PRP
cord-000248-zueoyesj	754	3	no	no	RB
cord-000248-zueoyesj	754	4	more	more	RBR
cord-000248-zueoyesj	754	5	a	a	DT
cord-000248-zueoyesj	754	6	demon	demon	NN
cord-000248-zueoyesj	754	7	but	but	CC
cord-000248-zueoyesj	754	8	a	a	DT
cord-000248-zueoyesj	754	9	valve	valve	NN
cord-000248-zueoyesj	754	10	like	like	IN
cord-000248-zueoyesj	754	11	that	that	DT
cord-000248-zueoyesj	754	12	of	of	IN
cord-000248-zueoyesj	754	13	the	the	DT
cord-000248-zueoyesj	754	14	hydraulic	hydraulic	JJ
cord-000248-zueoyesj	754	15	ram	ram	NN
cord-000248-zueoyesj	754	16	,	,	,
cord-000248-zueoyesj	754	17	suppose	suppose	VB
cord-000248-zueoyesj	754	18	.	.	.
cord-000248-zueoyesj	754	19	'	'	''
cord-000248-zueoyesj	754	20	'	'	''
cord-000248-zueoyesj	755	1	(	(	-LRB-
cord-000248-zueoyesj	755	2	from	from	IN
cord-000248-zueoyesj	755	3	[	[	-LRB-
cord-000248-zueoyesj	755	4	645	645	CD
cord-000248-zueoyesj	755	5	]	]	-RRB-
cord-000248-zueoyesj	755	6	,	,	,
cord-000248-zueoyesj	755	7	p.	p.	NN
cord-000248-zueoyesj	755	8	6	6	CD
cord-000248-zueoyesj	755	9	)	)	-RRB-
cord-000248-zueoyesj	755	10	.	.	.
cord-000248-zueoyesj	756	1	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	756	2	gives	give	VBZ
cord-000248-zueoyesj	756	3	again	again	RB
cord-000248-zueoyesj	756	4	here	here	RB
cord-000248-zueoyesj	756	5	a	a	DT
cord-000248-zueoyesj	756	6	sign	sign	NN
cord-000248-zueoyesj	756	7	of	of	IN
cord-000248-zueoyesj	756	8	his	-PRON-	PRP$
cord-000248-zueoyesj	756	9	brilliant	brilliant	JJ
cord-000248-zueoyesj	756	10	mind	mind	NN
cord-000248-zueoyesj	756	11	,	,	,
cord-000248-zueoyesj	756	12	'	'	''
cord-000248-zueoyesj	756	13	'	'	``
cord-000248-zueoyesj	756	14	degrading	degrade	VBG
cord-000248-zueoyesj	756	15	'	'	''
cord-000248-zueoyesj	756	16	'	'	''
cord-000248-zueoyesj	756	17	the	the	DT
cord-000248-zueoyesj	756	18	demon	demon	NN
cord-000248-zueoyesj	756	19	to	to	IN
cord-000248-zueoyesj	756	20	a	a	DT
cord-000248-zueoyesj	756	21	valve	valve	NN
cord-000248-zueoyesj	756	22	,	,	,
cord-000248-zueoyesj	756	23	but	but	CC
cord-000248-zueoyesj	756	24	also	also	RB
cord-000248-zueoyesj	756	25	offering	offer	VBG
cord-000248-zueoyesj	756	26	an	an	DT
cord-000248-zueoyesj	756	27	inspiring	inspiring	JJ
cord-000248-zueoyesj	756	28	perspective	perspective	NN
cord-000248-zueoyesj	756	29	to	to	IN
cord-000248-zueoyesj	756	30	oncosystems	oncosystem	VBZ
cord-000248-zueoyesj	756	31	research	research	NN
cord-000248-zueoyesj	756	32	.	.	.
cord-000248-zueoyesj	757	1	Which	which	WDT
cord-000248-zueoyesj	757	2	types	type	NNS
cord-000248-zueoyesj	757	3	of	of	IN
cord-000248-zueoyesj	757	4	mechanisms	mechanism	NNS
cord-000248-zueoyesj	757	5	exist	exist	VBP
cord-000248-zueoyesj	757	6	in	in	IN
cord-000248-zueoyesj	757	7	biological	biological	JJ
cord-000248-zueoyesj	757	8	systems	system	NNS
cord-000248-zueoyesj	757	9	,	,	,
cord-000248-zueoyesj	757	10	and	and	CC
cord-000248-zueoyesj	757	11	particularly	particularly	RB
cord-000248-zueoyesj	757	12	in	in	IN
cord-000248-zueoyesj	757	13	individual	individual	JJ
cord-000248-zueoyesj	757	14	cells	cell	NNS
cord-000248-zueoyesj	757	15	,	,	,
cord-000248-zueoyesj	757	16	to	to	TO
cord-000248-zueoyesj	757	17	control	control	VB
cord-000248-zueoyesj	757	18	these	these	DT
cord-000248-zueoyesj	757	19	differential	differential	JJ
cord-000248-zueoyesj	757	20	values	value	NNS
cord-000248-zueoyesj	757	21	in	in	IN
cord-000248-zueoyesj	757	22	key	key	JJ
cord-000248-zueoyesj	757	23	parameters	parameter	NNS
cord-000248-zueoyesj	757	24	?	?	.
cord-000248-zueoyesj	758	1	Could	Could	MD
cord-000248-zueoyesj	758	2	changes	change	NNS
cord-000248-zueoyesj	758	3	of	of	IN
cord-000248-zueoyesj	758	4	key	key	JJ
cord-000248-zueoyesj	758	5	physical	physical	JJ
cord-000248-zueoyesj	758	6	parameters	parameter	NNS
cord-000248-zueoyesj	758	7	for	for	IN
cord-000248-zueoyesj	758	8	metabolic	metabolic	JJ
cord-000248-zueoyesj	758	9	processes	process	NNS
cord-000248-zueoyesj	758	10	of	of	IN
cord-000248-zueoyesj	758	11	the	the	DT
cord-000248-zueoyesj	758	12	cytoplasm	cytoplasm	NN
cord-000248-zueoyesj	758	13	and	and	CC
cord-000248-zueoyesj	758	14	cell	cell	NN
cord-000248-zueoyesj	758	15	's	's	POS
cord-000248-zueoyesj	758	16	organelles	organelle	NNS
cord-000248-zueoyesj	758	17	like	like	IN
cord-000248-zueoyesj	758	18	temperature	temperature	NN
cord-000248-zueoyesj	758	19	,	,	,
cord-000248-zueoyesj	758	20	volume	volume	NN
cord-000248-zueoyesj	758	21	,	,	,
cord-000248-zueoyesj	758	22	pH	ph	NN
cord-000248-zueoyesj	758	23	or	or	CC
cord-000248-zueoyesj	758	24	electrochemical	electrochemical	JJ
cord-000248-zueoyesj	758	25	potentials	potential	NNS
cord-000248-zueoyesj	758	26	be	be	VB
cord-000248-zueoyesj	758	27	also	also	RB
cord-000248-zueoyesj	758	28	implicated	implicate	VBN
cord-000248-zueoyesj	758	29	in	in	IN
cord-000248-zueoyesj	758	30	cancer	cancer	NN
cord-000248-zueoyesj	758	31	progression	progression	NN
cord-000248-zueoyesj	758	32	?	?	.
cord-000248-zueoyesj	759	1	The	the	DT
cord-000248-zueoyesj	759	2	influence	influence	NN
cord-000248-zueoyesj	759	3	of	of	IN
cord-000248-zueoyesj	759	4	temperature	temperature	NN
cord-000248-zueoyesj	759	5	may	may	MD
cord-000248-zueoyesj	759	6	be	be	VB
cord-000248-zueoyesj	759	7	giving	give	VBG
cord-000248-zueoyesj	759	8	an	an	DT
cord-000248-zueoyesj	759	9	interesting	interesting	JJ
cord-000248-zueoyesj	759	10	working	working	NN
cord-000248-zueoyesj	759	11	hypothesis	hypothesis	NN
cord-000248-zueoyesj	759	12	for	for	IN
cord-000248-zueoyesj	759	13	further	further	JJ
cord-000248-zueoyesj	759	14	research	research	NN
cord-000248-zueoyesj	759	15	.	.	.
cord-000248-zueoyesj	760	1	What	what	WP
cord-000248-zueoyesj	760	2	are	be	VBP
cord-000248-zueoyesj	760	3	the	the	DT
cord-000248-zueoyesj	760	4	consequences	consequence	NNS
cord-000248-zueoyesj	760	5	if	if	IN
cord-000248-zueoyesj	760	6	cancer	cancer	NN
cord-000248-zueoyesj	760	7	cells	cell	NNS
cord-000248-zueoyesj	760	8	are	be	VBP
cord-000248-zueoyesj	760	9	a	a	DT
cord-000248-zueoyesj	760	10	different	different	JJ
cord-000248-zueoyesj	760	11	type	type	NN
cord-000248-zueoyesj	760	12	of	of	IN
cord-000248-zueoyesj	760	13	open	open	JJ
cord-000248-zueoyesj	760	14	system	system	NN
cord-000248-zueoyesj	760	15	which	which	WDT
cord-000248-zueoyesj	760	16	also	also	RB
cord-000248-zueoyesj	760	17	operates	operate	VBZ
cord-000248-zueoyesj	760	18	at	at	IN
cord-000248-zueoyesj	760	19	a	a	DT
cord-000248-zueoyesj	760	20	different	different	JJ
cord-000248-zueoyesj	760	21	temperature	temperature	NN
cord-000248-zueoyesj	760	22	than	than	IN
cord-000248-zueoyesj	760	23	a	a	DT
cord-000248-zueoyesj	760	24	normal	normal	JJ
cord-000248-zueoyesj	760	25	cell	cell	NN
cord-000248-zueoyesj	760	26	?	?	.
cord-000248-zueoyesj	761	1	Butler	Butler	NNP
cord-000248-zueoyesj	761	2	et	et	NNP
cord-000248-zueoyesj	761	3	al	al	NNP
cord-000248-zueoyesj	761	4	.	.	NNP
cord-000248-zueoyesj	761	5	have	have	VBP
cord-000248-zueoyesj	761	6	studied	study	VBN
cord-000248-zueoyesj	761	7	p53	p53	NN
cord-000248-zueoyesj	761	8	and	and	CC
cord-000248-zueoyesj	761	9	they	-PRON-	PRP
cord-000248-zueoyesj	761	10	argue	argue	VBP
cord-000248-zueoyesj	761	11	that	that	IN
cord-000248-zueoyesj	761	12	at	at	IN
cord-000248-zueoyesj	761	13	temperatures	temperature	NNS
cord-000248-zueoyesj	761	14	above	above	IN
cord-000248-zueoyesj	761	15	37	37	CD
cord-000248-zueoyesj	761	16	degrees	degree	NNS
cord-000248-zueoyesj	761	17	centigrades	centigrade	NNS
cord-000248-zueoyesj	762	1	wild	wild	JJ
cord-000248-zueoyesj	762	2	-	-	HYPH
cord-000248-zueoyesj	762	3	type	type	NN
cord-000248-zueoyesj	762	4	p53	p53	NN
cord-000248-zueoyesj	762	5	spontaneously	spontaneously	RB
cord-000248-zueoyesj	762	6	loses	lose	VBZ
cord-000248-zueoyesj	762	7	DNA	dna	NN
cord-000248-zueoyesj	762	8	binding	binding	NN
cord-000248-zueoyesj	762	9	activity	activity	NN
cord-000248-zueoyesj	762	10	.	.	.
cord-000248-zueoyesj	763	1	While	while	IN
cord-000248-zueoyesj	763	2	folding	fold	VBG
cord-000248-zueoyesj	763	3	kinetics	kinetic	NNS
cord-000248-zueoyesj	763	4	do	do	VBP
cord-000248-zueoyesj	763	5	not	not	RB
cord-000248-zueoyesj	763	6	show	show	VB
cord-000248-zueoyesj	763	7	important	important	JJ
cord-000248-zueoyesj	763	8	changes	change	NNS
cord-000248-zueoyesj	763	9	in	in	IN
cord-000248-zueoyesj	763	10	a	a	DT
cord-000248-zueoyesj	763	11	range	range	NN
cord-000248-zueoyesj	763	12	from	from	IN
cord-000248-zueoyesj	763	13	5	5	CD
cord-000248-zueoyesj	763	14	to	to	TO
cord-000248-zueoyesj	763	15	35	35	CD
cord-000248-zueoyesj	763	16	degrees	degree	NNS
cord-000248-zueoyesj	763	17	C	c	NN
cord-000248-zueoyesj	763	18	,	,	,
cord-000248-zueoyesj	763	19	the	the	DT
cord-000248-zueoyesj	763	20	unfolding	unfold	VBG
cord-000248-zueoyesj	763	21	rates	rate	NNS
cord-000248-zueoyesj	763	22	accelerate	accelerate	VBP
cord-000248-zueoyesj	763	23	10,000-fold	10,000-fold	CD
cord-000248-zueoyesj	763	24	.	.	.
cord-000248-zueoyesj	764	1	This	this	DT
cord-000248-zueoyesj	764	2	leads	lead	VBZ
cord-000248-zueoyesj	764	3	to	to	IN
cord-000248-zueoyesj	764	4	a	a	DT
cord-000248-zueoyesj	764	5	somewhat	somewhat	RB
cord-000248-zueoyesj	764	6	unexpected	unexpected	JJ
cord-000248-zueoyesj	764	7	mechanism	mechanism	NN
cord-000248-zueoyesj	764	8	of	of	IN
cord-000248-zueoyesj	764	9	p53	p53	NN
cord-000248-zueoyesj	764	10	inactivation	inactivation	NN
cord-000248-zueoyesj	764	11	.	.	.
cord-000248-zueoyesj	765	1	It	-PRON-	PRP
cord-000248-zueoyesj	765	2	could	could	MD
cord-000248-zueoyesj	765	3	be	be	VB
cord-000248-zueoyesj	765	4	the	the	DT
cord-000248-zueoyesj	765	5	case	case	NN
cord-000248-zueoyesj	765	6	that	that	IN
cord-000248-zueoyesj	765	7	a	a	DT
cord-000248-zueoyesj	765	8	fraction	fraction	NN
cord-000248-zueoyesj	765	9	of	of	IN
cord-000248-zueoyesj	765	10	p53	p53	NN
cord-000248-zueoyesj	765	11	molecules	molecule	NNS
cord-000248-zueoyesj	765	12	become	become	VBP
cord-000248-zueoyesj	765	13	trapped	trap	VBN
cord-000248-zueoyesj	765	14	in	in	IN
cord-000248-zueoyesj	765	15	misfolded	misfolded	JJ
cord-000248-zueoyesj	765	16	conformations	conformation	NNS
cord-000248-zueoyesj	765	17	with	with	IN
cord-000248-zueoyesj	765	18	each	each	DT
cord-000248-zueoyesj	765	19	folding	folding	NN
cord-000248-zueoyesj	765	20	-	-	HYPH
cord-000248-zueoyesj	765	21	unfolding	unfold	VBG
cord-000248-zueoyesj	765	22	cycle	cycle	NN
cord-000248-zueoyesj	765	23	due	due	IN
cord-000248-zueoyesj	765	24	to	to	IN
cord-000248-zueoyesj	765	25	the	the	DT
cord-000248-zueoyesj	765	26	increased	increase	VBN
cord-000248-zueoyesj	765	27	frequency	frequency	NN
cord-000248-zueoyesj	765	28	of	of	IN
cord-000248-zueoyesj	765	29	cycling	cycling	NN
cord-000248-zueoyesj	765	30	.	.	.
cord-000248-zueoyesj	766	1	The	the	DT
cord-000248-zueoyesj	766	2	occurrence	occurrence	NN
cord-000248-zueoyesj	766	3	of	of	IN
cord-000248-zueoyesj	766	4	misfolded	misfolde	VBN
cord-000248-zueoyesj	766	5	p53	p53	NN
cord-000248-zueoyesj	766	6	proteins	protein	NNS
cord-000248-zueoyesj	766	7	can	can	MD
cord-000248-zueoyesj	766	8	lead	lead	VB
cord-000248-zueoyesj	766	9	to	to	IN
cord-000248-zueoyesj	766	10	aggregation	aggregation	NN
cord-000248-zueoyesj	766	11	and	and	CC
cord-000248-zueoyesj	766	12	subsequent	subsequent	JJ
cord-000248-zueoyesj	766	13	ubiquitination	ubiquitination	NN
cord-000248-zueoyesj	766	14	in	in	IN
cord-000248-zueoyesj	766	15	the	the	DT
cord-000248-zueoyesj	766	16	cell	cell	NN
cord-000248-zueoyesj	766	17	,	,	,
cord-000248-zueoyesj	766	18	leading	lead	VBG
cord-000248-zueoyesj	766	19	to	to	IN
cord-000248-zueoyesj	766	20	p53	p53	NN
cord-000248-zueoyesj	766	21	inactivation	inactivation	NN
cord-000248-zueoyesj	766	22	[	[	-LRB-
cord-000248-zueoyesj	766	23	648	648	CD
cord-000248-zueoyesj	766	24	,	,	,
cord-000248-zueoyesj	766	25	649	649	CD
cord-000248-zueoyesj	766	26	]	]	-RRB-
cord-000248-zueoyesj	766	27	.	.	.
cord-000248-zueoyesj	767	1	If	if	IN
cord-000248-zueoyesj	767	2	a	a	DT
cord-000248-zueoyesj	767	3	key	key	NN
cord-000248-zueoyesj	767	4	'	'	''
cord-000248-zueoyesj	767	5	'	'	''
cord-000248-zueoyesj	767	6	guardian	guardian	NN
cord-000248-zueoyesj	767	7	of	of	IN
cord-000248-zueoyesj	767	8	the	the	DT
cord-000248-zueoyesj	767	9	genome	genome	NN
cord-000248-zueoyesj	767	10	integrity	integrity	NN
cord-000248-zueoyesj	767	11	'	'	''
cord-000248-zueoyesj	767	12	'	'	''
cord-000248-zueoyesj	767	13	[	[	-LRB-
cord-000248-zueoyesj	767	14	650	650	CD
cord-000248-zueoyesj	767	15	,	,	,
cord-000248-zueoyesj	767	16	651	651	CD
cord-000248-zueoyesj	767	17	]	]	-RRB-
cord-000248-zueoyesj	767	18	and	and	CC
cord-000248-zueoyesj	767	19	its	-PRON-	PRP$
cord-000248-zueoyesj	767	20	remarkable	remarkable	JJ
cord-000248-zueoyesj	767	21	conformational	conformational	JJ
cord-000248-zueoyesj	767	22	flexibility	flexibility	NN
cord-000248-zueoyesj	767	23	[	[	-LRB-
cord-000248-zueoyesj	767	24	652	652	CD
cord-000248-zueoyesj	767	25	]	]	-RRB-
cord-000248-zueoyesj	767	26	is	be	VBZ
cord-000248-zueoyesj	767	27	challenged	challenge	VBN
cord-000248-zueoyesj	767	28	by	by	IN
cord-000248-zueoyesj	767	29	an	an	DT
cord-000248-zueoyesj	767	30	increase	increase	NN
cord-000248-zueoyesj	767	31	of	of	IN
cord-000248-zueoyesj	767	32	temperature	temperature	NN
cord-000248-zueoyesj	767	33	[	[	-LRB-
cord-000248-zueoyesj	767	34	653	653	CD
cord-000248-zueoyesj	767	35	]	]	-RRB-
cord-000248-zueoyesj	767	36	,	,	,
cord-000248-zueoyesj	767	37	its	-PRON-	PRP$
cord-000248-zueoyesj	767	38	role	role	NN
cord-000248-zueoyesj	767	39	in	in	IN
cord-000248-zueoyesj	767	40	genotoxic	genotoxic	JJ
cord-000248-zueoyesj	767	41	damage	damage	NN
cord-000248-zueoyesj	767	42	and	and	CC
cord-000248-zueoyesj	767	43	adaptive	adaptive	JJ
cord-000248-zueoyesj	767	44	response	response	NN
cord-000248-zueoyesj	767	45	(	(	-LRB-
cord-000248-zueoyesj	767	46	like	like	IN
cord-000248-zueoyesj	767	47	that	that	DT
cord-000248-zueoyesj	767	48	of	of	IN
cord-000248-zueoyesj	767	49	the	the	DT
cord-000248-zueoyesj	767	50	skin	skin	NN
cord-000248-zueoyesj	767	51	to	to	IN
cord-000248-zueoyesj	767	52	UVB	uvb	NN
cord-000248-zueoyesj	767	53	damage	damage	NN
cord-000248-zueoyesj	767	54	[	[	-LRB-
cord-000248-zueoyesj	767	55	654	654	CD
cord-000248-zueoyesj	767	56	]	]	-RRB-
cord-000248-zueoyesj	767	57	)	)	-RRB-
cord-000248-zueoyesj	767	58	may	may	MD
cord-000248-zueoyesj	767	59	be	be	VB
cord-000248-zueoyesj	767	60	impaired	impair	VBN
cord-000248-zueoyesj	767	61	.	.	.
cord-000248-zueoyesj	768	1	The	the	DT
cord-000248-zueoyesj	768	2	same	same	JJ
cord-000248-zueoyesj	768	3	may	may	MD
cord-000248-zueoyesj	768	4	occur	occur	VB
cord-000248-zueoyesj	768	5	for	for	IN
cord-000248-zueoyesj	768	6	other	other	JJ
cord-000248-zueoyesj	768	7	members	member	NNS
cord-000248-zueoyesj	768	8	of	of	IN
cord-000248-zueoyesj	768	9	the	the	DT
cord-000248-zueoyesj	768	10	DNA	dna	NN
cord-000248-zueoyesj	768	11	damage	damage	NN
cord-000248-zueoyesj	768	12	response	response	NN
cord-000248-zueoyesj	768	13	.	.	.
cord-000248-zueoyesj	769	1	An	an	DT
cord-000248-zueoyesj	769	2	increment	increment	NN
cord-000248-zueoyesj	769	3	in	in	IN
cord-000248-zueoyesj	769	4	temperature	temperature	NN
cord-000248-zueoyesj	769	5	has	have	VBZ
cord-000248-zueoyesj	769	6	already	already	RB
cord-000248-zueoyesj	769	7	been	be	VBN
cord-000248-zueoyesj	769	8	linked	link	VBN
cord-000248-zueoyesj	769	9	to	to	IN
cord-000248-zueoyesj	769	10	skin	skin	NN
cord-000248-zueoyesj	769	11	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	769	12	.	.	.
cord-000248-zueoyesj	770	1	Boukamp	Boukamp	NNP
cord-000248-zueoyesj	770	2	et	et	FW
cord-000248-zueoyesj	770	3	al	al	NNP
cord-000248-zueoyesj	770	4	.	.	.
cord-000248-zueoyesj	771	1	report	report	VB
cord-000248-zueoyesj	771	2	in	in	IN
cord-000248-zueoyesj	771	3	that	that	DT
cord-000248-zueoyesj	771	4	[	[	-LRB-
cord-000248-zueoyesj	771	5	655	655	NN
cord-000248-zueoyesj	771	6	]	]	-RRB-
cord-000248-zueoyesj	771	7	'	'	``
cord-000248-zueoyesj	771	8	'	'	''
cord-000248-zueoyesj	771	9	exposure	exposure	NN
cord-000248-zueoyesj	771	10	of	of	IN
cord-000248-zueoyesj	771	11	immortal	immortal	JJ
cord-000248-zueoyesj	771	12	human	human	JJ
cord-000248-zueoyesj	771	13	HaCaT	HaCaT	NNP
cord-000248-zueoyesj	771	14	skin	skin	NN
cord-000248-zueoyesj	771	15	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	771	16	(	(	-LRB-
cord-000248-zueoyesj	771	17	possessing	possess	VBG
cord-000248-zueoyesj	771	18	UV	uv	NN
cord-000248-zueoyesj	771	19	-	-	HYPH
cord-000248-zueoyesj	771	20	type	type	NN
cord-000248-zueoyesj	771	21	p53	p53	NN
cord-000248-zueoyesj	771	22	mutations	mutation	NNS
cord-000248-zueoyesj	771	23	)	)	-RRB-
cord-000248-zueoyesj	771	24	to	to	IN
cord-000248-zueoyesj	771	25	40	40	CD
cord-000248-zueoyesj	771	26	degrees	degree	NNS
cord-000248-zueoyesj	771	27	C	c	NN
cord-000248-zueoyesj	771	28	reproducibly	reproducibly	RB
cord-000248-zueoyesj	771	29	resulted	result	VBD
cord-000248-zueoyesj	771	30	in	in	IN
cord-000248-zueoyesj	771	31	tumorigenic	tumorigenic	JJ
cord-000248-zueoyesj	771	32	conversion	conversion	NN
cord-000248-zueoyesj	771	33	and	and	CC
cord-000248-zueoyesj	771	34	tumorigenicity	tumorigenicity	NN
cord-000248-zueoyesj	771	35	was	be	VBD
cord-000248-zueoyesj	771	36	stably	stably	RB
cord-000248-zueoyesj	771	37	maintained	maintain	VBN
cord-000248-zueoyesj	771	38	after	after	IN
cord-000248-zueoyesj	771	39	recultivation	recultivation	NN
cord-000248-zueoyesj	771	40	of	of	IN
cord-000248-zueoyesj	771	41	the	the	DT
cord-000248-zueoyesj	771	42	tumors	tumor	NNS
cord-000248-zueoyesj	771	43	.	.	.
cord-000248-zueoyesj	771	44	'	'	''
cord-000248-zueoyesj	771	45	'	'	''
cord-000248-zueoyesj	772	1	On	on	IN
cord-000248-zueoyesj	772	2	the	the	DT
cord-000248-zueoyesj	772	3	other	other	JJ
cord-000248-zueoyesj	772	4	hand	hand	NN
cord-000248-zueoyesj	772	5	,	,	,
cord-000248-zueoyesj	772	6	natural	natural	JJ
cord-000248-zueoyesj	772	7	gradients	gradient	NNS
cord-000248-zueoyesj	772	8	on	on	IN
cord-000248-zueoyesj	772	9	physical	physical	JJ
cord-000248-zueoyesj	772	10	biochemical	biochemical	JJ
cord-000248-zueoyesj	772	11	properties	property	NNS
cord-000248-zueoyesj	772	12	can	can	MD
cord-000248-zueoyesj	772	13	also	also	RB
cord-000248-zueoyesj	772	14	be	be	VB
cord-000248-zueoyesj	772	15	challenged	challenge	VBN
cord-000248-zueoyesj	772	16	in	in	IN
cord-000248-zueoyesj	772	17	a	a	DT
cord-000248-zueoyesj	772	18	cancer	cancer	NN
cord-000248-zueoyesj	772	19	cell	cell	NN
cord-000248-zueoyesj	772	20	.	.	.
cord-000248-zueoyesj	773	1	This	this	DT
cord-000248-zueoyesj	773	2	in	in	IN
cord-000248-zueoyesj	773	3	turn	turn	NN
cord-000248-zueoyesj	773	4	derives	derive	VBZ
cord-000248-zueoyesj	773	5	in	in	IN
cord-000248-zueoyesj	773	6	metabolic	metabolic	JJ
cord-000248-zueoyesj	773	7	processes	process	NNS
cord-000248-zueoyesj	773	8	running	run	VBG
cord-000248-zueoyesj	773	9	under	under	IN
cord-000248-zueoyesj	773	10	abnormal	abnormal	JJ
cord-000248-zueoyesj	773	11	parametric	parametric	JJ
cord-000248-zueoyesj	773	12	circumstances	circumstance	NNS
cord-000248-zueoyesj	773	13	.	.	.
cord-000248-zueoyesj	774	1	It	-PRON-	PRP
cord-000248-zueoyesj	774	2	is	be	VBZ
cord-000248-zueoyesj	774	3	well	well	RB
cord-000248-zueoyesj	774	4	-	-	HYPH
cord-000248-zueoyesj	774	5	known	know	VBN
cord-000248-zueoyesj	774	6	that	that	DT
cord-000248-zueoyesj	774	7	compartimentalization	compartimentalization	NN
cord-000248-zueoyesj	774	8	,	,	,
cord-000248-zueoyesj	774	9	in	in	IN
cord-000248-zueoyesj	774	10	biological	biological	JJ
cord-000248-zueoyesj	774	11	systems	system	NNS
cord-000248-zueoyesj	774	12	,	,	,
cord-000248-zueoyesj	774	13	naturally	naturally	RB
cord-000248-zueoyesj	774	14	require	require	VBP
cord-000248-zueoyesj	774	15	the	the	DT
cord-000248-zueoyesj	774	16	existence	existence	NN
cord-000248-zueoyesj	774	17	of	of	IN
cord-000248-zueoyesj	774	18	mechanisms	mechanism	NNS
cord-000248-zueoyesj	774	19	that	that	WDT
cord-000248-zueoyesj	774	20	would	would	MD
cord-000248-zueoyesj	774	21	keep	keep	VB
cord-000248-zueoyesj	774	22	some	some	DT
cord-000248-zueoyesj	774	23	key	key	JJ
cord-000248-zueoyesj	774	24	state	state	NN
cord-000248-zueoyesj	774	25	variables	variable	NNS
cord-000248-zueoyesj	774	26	relatively	relatively	RB
cord-000248-zueoyesj	774	27	constant	constant	JJ
cord-000248-zueoyesj	774	28	,	,	,
cord-000248-zueoyesj	774	29	or	or	CC
cord-000248-zueoyesj	774	30	within	within	IN
cord-000248-zueoyesj	774	31	bounds	bound	NNS
cord-000248-zueoyesj	774	32	,	,	,
cord-000248-zueoyesj	774	33	for	for	IN
cord-000248-zueoyesj	774	34	normal	normal	JJ
cord-000248-zueoyesj	774	35	operation	operation	NN
cord-000248-zueoyesj	774	36	of	of	IN
cord-000248-zueoyesj	774	37	the	the	DT
cord-000248-zueoyesj	774	38	metabolic	metabolic	JJ
cord-000248-zueoyesj	774	39	processes	process	NNS
cord-000248-zueoyesj	774	40	.	.	.
cord-000248-zueoyesj	775	1	One	one	CD
cord-000248-zueoyesj	775	2	example	example	NN
cord-000248-zueoyesj	775	3	is	be	VBZ
cord-000248-zueoyesj	775	4	very	very	RB
cord-000248-zueoyesj	775	5	illustrative	illustrative	JJ
cord-000248-zueoyesj	775	6	and	and	CC
cord-000248-zueoyesj	775	7	a	a	DT
cord-000248-zueoyesj	775	8	case	case	NN
cord-000248-zueoyesj	775	9	in	in	IN
cord-000248-zueoyesj	775	10	point	point	NN
cord-000248-zueoyesj	775	11	.	.	.
cord-000248-zueoyesj	776	1	Instead	instead	RB
cord-000248-zueoyesj	776	2	of	of	IN
cord-000248-zueoyesj	776	3	demons	demon	NNS
cord-000248-zueoyesj	776	4	,	,	,
cord-000248-zueoyesj	776	5	holes	hole	NNS
cord-000248-zueoyesj	776	6	,	,	,
cord-000248-zueoyesj	776	7	or	or	CC
cord-000248-zueoyesj	776	8	valves	valve	NNS
cord-000248-zueoyesj	776	9	,	,	,
cord-000248-zueoyesj	776	10	the	the	DT
cord-000248-zueoyesj	776	11	cell	cell	NN
cord-000248-zueoyesj	776	12	requires	require	VBZ
cord-000248-zueoyesj	776	13	pores	pore	NNS
cord-000248-zueoyesj	776	14	in	in	IN
cord-000248-zueoyesj	776	15	its	-PRON-	PRP$
cord-000248-zueoyesj	776	16	membranes	membrane	NNS
cord-000248-zueoyesj	776	17	to	to	TO
cord-000248-zueoyesj	776	18	allow	allow	VB
cord-000248-zueoyesj	776	19	osmotic	osmotic	JJ
cord-000248-zueoyesj	776	20	regulatory	regulatory	JJ
cord-000248-zueoyesj	776	21	processes	process	NNS
cord-000248-zueoyesj	776	22	,	,	,
cord-000248-zueoyesj	776	23	yet	yet	CC
cord-000248-zueoyesj	776	24	it	-PRON-	PRP
cord-000248-zueoyesj	776	25	should	should	MD
cord-000248-zueoyesj	776	26	preclude	preclude	VB
cord-000248-zueoyesj	776	27	the	the	DT
cord-000248-zueoyesj	776	28	conduction	conduction	NN
cord-000248-zueoyesj	776	29	of	of	IN
cord-000248-zueoyesj	776	30	protons	proton	NNS
cord-000248-zueoyesj	776	31	.	.	.
cord-000248-zueoyesj	777	1	This	this	DT
cord-000248-zueoyesj	777	2	is	be	VBZ
cord-000248-zueoyesj	777	3	a	a	DT
cord-000248-zueoyesj	777	4	nanotechnological	nanotechnological	JJ
cord-000248-zueoyesj	777	5	design	design	NN
cord-000248-zueoyesj	777	6	problem	problem	NN
cord-000248-zueoyesj	777	7	not	not	RB
cord-000248-zueoyesj	777	8	faced	face	VBN
cord-000248-zueoyesj	777	9	by	by	IN
cord-000248-zueoyesj	777	10	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	777	11	,	,	,
cord-000248-zueoyesj	777	12	but	but	CC
cord-000248-zueoyesj	777	13	certainly	certainly	RB
cord-000248-zueoyesj	777	14	solved	solve	VBN
cord-000248-zueoyesj	777	15	by	by	IN
cord-000248-zueoyesj	777	16	biological	biological	JJ
cord-000248-zueoyesj	777	17	systems	system	NNS
cord-000248-zueoyesj	777	18	without	without	IN
cord-000248-zueoyesj	777	19	the	the	DT
cord-000248-zueoyesj	777	20	need	need	NN
cord-000248-zueoyesj	777	21	of	of	IN
cord-000248-zueoyesj	777	22	an	an	DT
cord-000248-zueoyesj	777	23	'	'	''
cord-000248-zueoyesj	777	24	'	'	``
cord-000248-zueoyesj	777	25	intelligent	intelligent	JJ
cord-000248-zueoyesj	777	26	being	being	NN
cord-000248-zueoyesj	777	27	'	'	''
cord-000248-zueoyesj	777	28	'	'	''
cord-000248-zueoyesj	777	29	as	as	IN
cord-000248-zueoyesj	777	30	Mawell	Mawell	NNP
cord-000248-zueoyesj	777	31	cleverly	cleverly	RB
cord-000248-zueoyesj	777	32	pointed	point	VBD
cord-000248-zueoyesj	777	33	to	to	IN
cord-000248-zueoyesj	777	34	Tait	Tait	NNP
cord-000248-zueoyesj	777	35	in	in	IN
cord-000248-zueoyesj	777	36	his	-PRON-	PRP$
cord-000248-zueoyesj	777	37	letter	letter	NN
cord-000248-zueoyesj	777	38	.	.	.
cord-000248-zueoyesj	778	1	This	this	DT
cord-000248-zueoyesj	778	2	discussion	discussion	NN
cord-000248-zueoyesj	778	3	brings	bring	VBZ
cord-000248-zueoyesj	778	4	us	-PRON-	PRP
cord-000248-zueoyesj	778	5	to	to	IN
cord-000248-zueoyesj	778	6	one	one	CD
cord-000248-zueoyesj	778	7	of	of	IN
cord-000248-zueoyesj	778	8	the	the	DT
cord-000248-zueoyesj	778	9	gene	gene	NN
cord-000248-zueoyesj	778	10	families	family	NNS
cord-000248-zueoyesj	778	11	we	-PRON-	PRP
cord-000248-zueoyesj	778	12	have	have	VBP
cord-000248-zueoyesj	778	13	already	already	RB
cord-000248-zueoyesj	778	14	discussed	discuss	VBN
cord-000248-zueoyesj	778	15	in	in	IN
cord-000248-zueoyesj	778	16	this	this	DT
cord-000248-zueoyesj	778	17	paper	paper	NN
cord-000248-zueoyesj	778	18	,	,	,
cord-000248-zueoyesj	778	19	the	the	DT
cord-000248-zueoyesj	778	20	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	778	21	[	[	-LRB-
cord-000248-zueoyesj	778	22	184	184	CD
cord-000248-zueoyesj	778	23	,	,	,
cord-000248-zueoyesj	778	24	656	656	CD
cord-000248-zueoyesj	778	25	,	,	,
cord-000248-zueoyesj	778	26	657	657	CD
cord-000248-zueoyesj	778	27	,	,	,
cord-000248-zueoyesj	778	28	658	658	CD
cord-000248-zueoyesj	778	29	,	,	,
cord-000248-zueoyesj	778	30	659	659	CD
cord-000248-zueoyesj	778	31	,	,	,
cord-000248-zueoyesj	778	32	660	660	CD
cord-000248-zueoyesj	778	33	,	,	,
cord-000248-zueoyesj	778	34	661	661	CD
cord-000248-zueoyesj	778	35	]	]	-RRB-
cord-000248-zueoyesj	778	36	.	.	.
cord-000248-zueoyesj	779	1	They	-PRON-	PRP
cord-000248-zueoyesj	779	2	are	be	VBP
cord-000248-zueoyesj	779	3	considered	consider	VBN
cord-000248-zueoyesj	779	4	the	the	DT
cord-000248-zueoyesj	779	5	primary	primary	JJ
cord-000248-zueoyesj	779	6	water	water	NN
cord-000248-zueoyesj	779	7	channels	channel	NNS
cord-000248-zueoyesj	779	8	of	of	IN
cord-000248-zueoyesj	779	9	cell	cell	NN
cord-000248-zueoyesj	779	10	membranes	membrane	NNS
cord-000248-zueoyesj	779	11	[	[	-LRB-
cord-000248-zueoyesj	779	12	662	662	CD
cord-000248-zueoyesj	779	13	,	,	,
cord-000248-zueoyesj	779	14	663	663	CD
cord-000248-zueoyesj	779	15	,	,	,
cord-000248-zueoyesj	779	16	664	664	CD
cord-000248-zueoyesj	779	17	,	,	,
cord-000248-zueoyesj	779	18	665	665	CD
cord-000248-zueoyesj	779	19	]	]	-RRB-
cord-000248-zueoyesj	779	20	.	.	.
cord-000248-zueoyesj	780	1	The	the	DT
cord-000248-zueoyesj	780	2	specific	specific	JJ
cord-000248-zueoyesj	780	3	functions	function	NNS
cord-000248-zueoyesj	780	4	of	of	IN
cord-000248-zueoyesj	780	5	each	each	DT
cord-000248-zueoyesj	780	6	member	member	NN
cord-000248-zueoyesj	780	7	of	of	IN
cord-000248-zueoyesj	780	8	this	this	DT
cord-000248-zueoyesj	780	9	family	family	NN
cord-000248-zueoyesj	780	10	are	be	VBP
cord-000248-zueoyesj	780	11	now	now	RB
cord-000248-zueoyesj	780	12	being	be	VBG
cord-000248-zueoyesj	780	13	slowly	slowly	RB
cord-000248-zueoyesj	780	14	mapped	map	VBN
cord-000248-zueoyesj	780	15	by	by	IN
cord-000248-zueoyesj	780	16	several	several	JJ
cord-000248-zueoyesj	780	17	research	research	NN
cord-000248-zueoyesj	780	18	labs	lab	NNS
cord-000248-zueoyesj	780	19	around	around	IN
cord-000248-zueoyesj	780	20	the	the	DT
cord-000248-zueoyesj	780	21	world	world	NN
cord-000248-zueoyesj	780	22	[	[	-LRB-
cord-000248-zueoyesj	780	23	666	666	CD
cord-000248-zueoyesj	780	24	]	]	-RRB-
cord-000248-zueoyesj	780	25	.	.	.
cord-000248-zueoyesj	781	1	Their	-PRON-	PRP$
cord-000248-zueoyesj	781	2	clinical	clinical	JJ
cord-000248-zueoyesj	781	3	role	role	NN
cord-000248-zueoyesj	781	4	in	in	IN
cord-000248-zueoyesj	781	5	cancer	cancer	NN
cord-000248-zueoyesj	781	6	[	[	-LRB-
cord-000248-zueoyesj	781	7	667	667	CD
cord-000248-zueoyesj	781	8	,	,	,
cord-000248-zueoyesj	781	9	668	668	CD
cord-000248-zueoyesj	781	10	,	,	,
cord-000248-zueoyesj	781	11	669	669	CD
cord-000248-zueoyesj	781	12	,	,	,
cord-000248-zueoyesj	781	13	670	670	CD
cord-000248-zueoyesj	781	14	,	,	,
cord-000248-zueoyesj	781	15	671	671	CD
cord-000248-zueoyesj	781	16	,	,	,
cord-000248-zueoyesj	781	17	672	672	CD
cord-000248-zueoyesj	781	18	,	,	,
cord-000248-zueoyesj	781	19	673	673	CD
cord-000248-zueoyesj	781	20	,	,	,
cord-000248-zueoyesj	781	21	674	674	CD
cord-000248-zueoyesj	781	22	,	,	,
cord-000248-zueoyesj	781	23	675	675	CD
cord-000248-zueoyesj	781	24	]	]	-RRB-
cord-000248-zueoyesj	781	25	,	,	,
cord-000248-zueoyesj	781	26	obesity	obesity	NN
cord-000248-zueoyesj	781	27	[	[	-LRB-
cord-000248-zueoyesj	781	28	676	676	CD
cord-000248-zueoyesj	781	29	]	]	-RRB-
cord-000248-zueoyesj	781	30	,	,	,
cord-000248-zueoyesj	781	31	malaria	malaria	FW
cord-000248-zueoyesj	781	32	[	[	-LRB-
cord-000248-zueoyesj	781	33	677	677	CD
cord-000248-zueoyesj	781	34	,	,	,
cord-000248-zueoyesj	781	35	678	678	CD
cord-000248-zueoyesj	781	36	]	]	-RRB-
cord-000248-zueoyesj	781	37	and	and	CC
cord-000248-zueoyesj	781	38	other	other	JJ
cord-000248-zueoyesj	781	39	diseases	disease	NNS
cord-000248-zueoyesj	781	40	is	be	VBZ
cord-000248-zueoyesj	781	41	emerging	emerge	VBG
cord-000248-zueoyesj	781	42	[	[	-LRB-
cord-000248-zueoyesj	781	43	657	657	CD
cord-000248-zueoyesj	781	44	,	,	,
cord-000248-zueoyesj	781	45	679	679	CD
cord-000248-zueoyesj	781	46	,	,	,
cord-000248-zueoyesj	781	47	680	680	CD
cord-000248-zueoyesj	781	48	,	,	,
cord-000248-zueoyesj	781	49	681	681	CD
cord-000248-zueoyesj	781	50	,	,	,
cord-000248-zueoyesj	781	51	682	682	CD
cord-000248-zueoyesj	781	52	,	,	,
cord-000248-zueoyesj	781	53	683	683	CD
cord-000248-zueoyesj	781	54	,	,	,
cord-000248-zueoyesj	781	55	684	684	CD
cord-000248-zueoyesj	781	56	,	,	,
cord-000248-zueoyesj	781	57	685	685	CD
cord-000248-zueoyesj	781	58	,	,	,
cord-000248-zueoyesj	781	59	686	686	CD
cord-000248-zueoyesj	781	60	,	,	,
cord-000248-zueoyesj	781	61	687	687	CD
cord-000248-zueoyesj	781	62	,	,	,
cord-000248-zueoyesj	781	63	688	688	CD
cord-000248-zueoyesj	781	64	,	,	,
cord-000248-zueoyesj	781	65	689	689	CD
cord-000248-zueoyesj	781	66	]	]	-RRB-
cord-000248-zueoyesj	781	67	.	.	.
cord-000248-zueoyesj	782	1	In	in	IN
cord-000248-zueoyesj	782	2	[	[	-LRB-
cord-000248-zueoyesj	782	3	690	690	CD
cord-000248-zueoyesj	782	4	]	]	-RRB-
cord-000248-zueoyesj	782	5	,	,	,
cord-000248-zueoyesj	782	6	our	-PRON-	PRP$
cord-000248-zueoyesj	782	7	group	group	NN
cord-000248-zueoyesj	782	8	observed	observe	VBD
cord-000248-zueoyesj	782	9	the	the	DT
cord-000248-zueoyesj	782	10	dowregulation	dowregulation	NN
cord-000248-zueoyesj	782	11	of	of	IN
cord-000248-zueoyesj	782	12	AQP3	AQP3	NNP
cord-000248-zueoyesj	782	13	in	in	IN
cord-000248-zueoyesj	782	14	all	all	DT
cord-000248-zueoyesj	782	15	melanoma	melanoma	NN
cord-000248-zueoyesj	782	16	cell	cell	NN
cord-000248-zueoyesj	782	17	lines	line	NNS
cord-000248-zueoyesj	782	18	studied	study	VBN
cord-000248-zueoyesj	782	19	of	of	IN
cord-000248-zueoyesj	782	20	the	the	DT
cord-000248-zueoyesj	782	21	NCI-60	NCI-60	NNP
cord-000248-zueoyesj	782	22	dataset	dataset	NN
cord-000248-zueoyesj	782	23	of	of	IN
cord-000248-zueoyesj	782	24	Ross	Ross	NNP
cord-000248-zueoyesj	782	25	et	et	NNP
cord-000248-zueoyesj	782	26	al	al	NNP
cord-000248-zueoyesj	782	27	.	.	NNP
cord-000248-zueoyesj	782	28	;	;	:
cord-000248-zueoyesj	782	29	this	this	DT
cord-000248-zueoyesj	782	30	dowregulation	dowregulation	NN
cord-000248-zueoyesj	782	31	was	be	VBD
cord-000248-zueoyesj	782	32	also	also	RB
cord-000248-zueoyesj	782	33	observed	observe	VBN
cord-000248-zueoyesj	782	34	for	for	IN
cord-000248-zueoyesj	782	35	the	the	DT
cord-000248-zueoyesj	782	36	CNS	CNS	NNP
cord-000248-zueoyesj	782	37	and	and	CC
cord-000248-zueoyesj	782	38	Renal	renal	JJ
cord-000248-zueoyesj	782	39	cell	cell	NN
cord-000248-zueoyesj	782	40	lines	line	NNS
cord-000248-zueoyesj	782	41	.	.	.
cord-000248-zueoyesj	783	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	783	2	was	be	VBD
cord-000248-zueoyesj	783	3	relatively	relatively	RB
cord-000248-zueoyesj	783	4	upregulated	upregulate	VBN
cord-000248-zueoyesj	783	5	for	for	IN
cord-000248-zueoyesj	783	6	Leukaemia	Leukaemia	NNP
cord-000248-zueoyesj	783	7	and	and	CC
cord-000248-zueoyesj	783	8	Colon	colon	NN
cord-000248-zueoyesj	783	9	cell	cell	NN
cord-000248-zueoyesj	783	10	-	-	HYPH
cord-000248-zueoyesj	783	11	lines	line	NNS
cord-000248-zueoyesj	783	12	(	(	-LRB-
cord-000248-zueoyesj	783	13	we	-PRON-	PRP
cord-000248-zueoyesj	783	14	refer	refer	VBP
cord-000248-zueoyesj	783	15	the	the	DT
cord-000248-zueoyesj	783	16	reader	reader	NN
cord-000248-zueoyesj	783	17	to	to	IN
cord-000248-zueoyesj	783	18	the	the	DT
cord-000248-zueoyesj	783	19	Supplementary	Supplementary	NNP
cord-000248-zueoyesj	783	20	Material	Material	NNP
cord-000248-zueoyesj	783	21	of	of	IN
cord-000248-zueoyesj	783	22	[	[	-LRB-
cord-000248-zueoyesj	783	23	690	690	CD
cord-000248-zueoyesj	783	24	]	]	-RRB-
cord-000248-zueoyesj	783	25	for	for	IN
cord-000248-zueoyesj	783	26	details	detail	NNS
cord-000248-zueoyesj	783	27	)	)	-RRB-
cord-000248-zueoyesj	783	28	.	.	.
cord-000248-zueoyesj	784	1	Inhibition	inhibition	NN
cord-000248-zueoyesj	784	2	of	of	IN
cord-000248-zueoyesj	784	3	AQP3	AQP3	NNP
cord-000248-zueoyesj	784	4	in	in	IN
cord-000248-zueoyesj	784	5	prostate	prostate	NN
cord-000248-zueoyesj	784	6	cancer	cancer	NN
cord-000248-zueoyesj	784	7	cells	cell	NNS
cord-000248-zueoyesj	784	8	was	be	VBD
cord-000248-zueoyesj	784	9	already	already	RB
cord-000248-zueoyesj	784	10	proposed	propose	VBN
cord-000248-zueoyesj	784	11	as	as	IN
cord-000248-zueoyesj	784	12	a	a	DT
cord-000248-zueoyesj	784	13	mechanism	mechanism	NN
cord-000248-zueoyesj	784	14	that	that	WDT
cord-000248-zueoyesj	784	15	increases	increase	VBZ
cord-000248-zueoyesj	784	16	the	the	DT
cord-000248-zueoyesj	784	17	sensitivity	sensitivity	NN
cord-000248-zueoyesj	784	18	to	to	IN
cord-000248-zueoyesj	784	19	cryotherapy	cryotherapy	NN
cord-000248-zueoyesj	784	20	treatment	treatment	NN
cord-000248-zueoyesj	784	21	[	[	-LRB-
cord-000248-zueoyesj	784	22	691	691	CD
cord-000248-zueoyesj	784	23	]	]	-RRB-
cord-000248-zueoyesj	784	24	.	.	.
cord-000248-zueoyesj	785	1	The	the	DT
cord-000248-zueoyesj	785	2	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	785	3	are	be	VBP
cord-000248-zueoyesj	785	4	not	not	RB
cord-000248-zueoyesj	785	5	'	'	``
cord-000248-zueoyesj	785	6	'	'	''
cord-000248-zueoyesj	785	7	an	an	DT
cord-000248-zueoyesj	785	8	intelligent	intelligent	JJ
cord-000248-zueoyesj	785	9	being	being	NN
cord-000248-zueoyesj	785	10	'	'	''
cord-000248-zueoyesj	785	11	'	'	''
cord-000248-zueoyesj	785	12	in	in	IN
cord-000248-zueoyesj	785	13	any	any	DT
cord-000248-zueoyesj	785	14	real	real	JJ
cord-000248-zueoyesj	785	15	sense	sense	NN
cord-000248-zueoyesj	785	16	,	,	,
cord-000248-zueoyesj	785	17	yet	yet	CC
cord-000248-zueoyesj	785	18	they	-PRON-	PRP
cord-000248-zueoyesj	785	19	are	be	VBP
cord-000248-zueoyesj	785	20	so	so	RB
cord-000248-zueoyesj	785	21	formidable	formidable	JJ
cord-000248-zueoyesj	785	22	selective	selective	JJ
cord-000248-zueoyesj	785	23	that	that	IN
cord-000248-zueoyesj	785	24	they	-PRON-	PRP
cord-000248-zueoyesj	785	25	could	could	MD
cord-000248-zueoyesj	785	26	easily	easily	RB
cord-000248-zueoyesj	785	27	parallel	parallel	VB
cord-000248-zueoyesj	785	28	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	785	29	demon	demon	NN
cord-000248-zueoyesj	785	30	's	's	POS
cord-000248-zueoyesj	785	31	efficiency	efficiency	NN
cord-000248-zueoyesj	785	32	in	in	IN
cord-000248-zueoyesj	785	33	creating	create	VBG
cord-000248-zueoyesj	785	34	the	the	DT
cord-000248-zueoyesj	785	35	right	right	JJ
cord-000248-zueoyesj	785	36	conditions	condition	NNS
cord-000248-zueoyesj	785	37	for	for	IN
cord-000248-zueoyesj	785	38	the	the	DT
cord-000248-zueoyesj	785	39	cell	cell	NN
cord-000248-zueoyesj	785	40	.	.	.
cord-000248-zueoyesj	786	1	Wu	Wu	NNP
cord-000248-zueoyesj	786	2	et	et	NNP
cord-000248-zueoyesj	786	3	al	al	NNP
cord-000248-zueoyesj	786	4	.	.	.
cord-000248-zueoyesj	787	1	give	give	VB
cord-000248-zueoyesj	787	2	us	-PRON-	PRP
cord-000248-zueoyesj	787	3	some	some	DT
cord-000248-zueoyesj	787	4	clues	clue	NNS
cord-000248-zueoyesj	787	5	on	on	IN
cord-000248-zueoyesj	787	6	the	the	DT
cord-000248-zueoyesj	787	7	role	role	NN
cord-000248-zueoyesj	787	8	of	of	IN
cord-000248-zueoyesj	787	9	point	point	NN
cord-000248-zueoyesj	787	10	mutations	mutation	NNS
cord-000248-zueoyesj	787	11	in	in	IN
cord-000248-zueoyesj	787	12	the	the	DT
cord-000248-zueoyesj	787	13	AQP1	AQP1	NNP
cord-000248-zueoyesj	787	14	and	and	CC
cord-000248-zueoyesj	787	15	how	how	WRB
cord-000248-zueoyesj	787	16	their	-PRON-	PRP$
cord-000248-zueoyesj	787	17	effective	effective	JJ
cord-000248-zueoyesj	787	18	electrostatic	electrostatic	JJ
cord-000248-zueoyesj	787	19	proton	proton	NN
cord-000248-zueoyesj	787	20	barrier	barrier	NN
cord-000248-zueoyesj	787	21	can	can	MD
cord-000248-zueoyesj	787	22	be	be	VB
cord-000248-zueoyesj	787	23	impaired	impair	VBN
cord-000248-zueoyesj	787	24	[	[	-LRB-
cord-000248-zueoyesj	787	25	692	692	CD
cord-000248-zueoyesj	787	26	]	]	-RRB-
cord-000248-zueoyesj	787	27	.	.	.
cord-000248-zueoyesj	788	1	The	the	DT
cord-000248-zueoyesj	788	2	elicitation	elicitation	NN
cord-000248-zueoyesj	788	3	of	of	IN
cord-000248-zueoyesj	788	4	the	the	DT
cord-000248-zueoyesj	788	5	detailed	detailed	JJ
cord-000248-zueoyesj	788	6	mechanistic	mechanistic	JJ
cord-000248-zueoyesj	788	7	explanation	explanation	NN
cord-000248-zueoyesj	788	8	of	of	IN
cord-000248-zueoyesj	788	9	this	this	DT
cord-000248-zueoyesj	788	10	extraordinary	extraordinary	JJ
cord-000248-zueoyesj	788	11	selectivity	selectivity	NN
cord-000248-zueoyesj	788	12	is	be	VBZ
cord-000248-zueoyesj	788	13	under	under	IN
cord-000248-zueoyesj	788	14	intense	intense	JJ
cord-000248-zueoyesj	788	15	investigation	investigation	NN
cord-000248-zueoyesj	788	16	with	with	IN
cord-000248-zueoyesj	788	17	a	a	DT
cord-000248-zueoyesj	788	18	number	number	NN
cord-000248-zueoyesj	788	19	of	of	IN
cord-000248-zueoyesj	788	20	techniques	technique	NNS
cord-000248-zueoyesj	788	21	,	,	,
cord-000248-zueoyesj	788	22	including	include	VBG
cord-000248-zueoyesj	788	23	sophisticated	sophisticated	JJ
cord-000248-zueoyesj	788	24	molecular	molecular	JJ
cord-000248-zueoyesj	788	25	dyanamics	dyanamic	NNS
cord-000248-zueoyesj	788	26	simulations	simulation	NNS
cord-000248-zueoyesj	788	27	,	,	,
cord-000248-zueoyesj	788	28	for	for	IN
cord-000248-zueoyesj	788	29	an	an	DT
cord-000248-zueoyesj	788	30	overview	overview	NN
cord-000248-zueoyesj	788	31	of	of	IN
cord-000248-zueoyesj	788	32	this	this	DT
cord-000248-zueoyesj	788	33	field	field	NN
cord-000248-zueoyesj	788	34	see	see	VBP
cord-000248-zueoyesj	788	35	[	[	-LRB-
cord-000248-zueoyesj	788	36	665	665	CD
cord-000248-zueoyesj	788	37	,	,	,
cord-000248-zueoyesj	788	38	693	693	CD
cord-000248-zueoyesj	788	39	,	,	,
cord-000248-zueoyesj	788	40	694	694	CD
cord-000248-zueoyesj	788	41	,	,	,
cord-000248-zueoyesj	788	42	695	695	CD
cord-000248-zueoyesj	788	43	,	,	,
cord-000248-zueoyesj	788	44	696	696	CD
cord-000248-zueoyesj	788	45	,	,	,
cord-000248-zueoyesj	788	46	697	697	CD
cord-000248-zueoyesj	788	47	,	,	,
cord-000248-zueoyesj	788	48	698	698	CD
cord-000248-zueoyesj	788	49	,	,	,
cord-000248-zueoyesj	788	50	699	699	CD
cord-000248-zueoyesj	788	51	,	,	,
cord-000248-zueoyesj	788	52	700	700	CD
cord-000248-zueoyesj	788	53	,	,	,
cord-000248-zueoyesj	788	54	701	701	CD
cord-000248-zueoyesj	788	55	,	,	,
cord-000248-zueoyesj	788	56	702	702	CD
cord-000248-zueoyesj	788	57	,	,	,
cord-000248-zueoyesj	788	58	703	703	CD
cord-000248-zueoyesj	788	59	,	,	,
cord-000248-zueoyesj	788	60	704	704	CD
cord-000248-zueoyesj	788	61	,	,	,
cord-000248-zueoyesj	788	62	705	705	CD
cord-000248-zueoyesj	788	63	,	,	,
cord-000248-zueoyesj	788	64	706	706	CD
cord-000248-zueoyesj	788	65	,	,	,
cord-000248-zueoyesj	788	66	707	707	CD
cord-000248-zueoyesj	788	67	,	,	,
cord-000248-zueoyesj	788	68	708	708	CD
cord-000248-zueoyesj	788	69	]	]	-RRB-
cord-000248-zueoyesj	788	70	.	.	.
cord-000248-zueoyesj	789	1	One	one	CD
cord-000248-zueoyesj	789	2	less	less	RBR
cord-000248-zueoyesj	789	3	known	know	VBN
cord-000248-zueoyesj	789	4	feature	feature	NN
cord-000248-zueoyesj	789	5	of	of	IN
cord-000248-zueoyesj	789	6	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	789	7	is	be	VBZ
cord-000248-zueoyesj	789	8	that	that	IN
cord-000248-zueoyesj	789	9	they	-PRON-	PRP
cord-000248-zueoyesj	789	10	may	may	MD
cord-000248-zueoyesj	789	11	not	not	RB
cord-000248-zueoyesj	789	12	only	only	RB
cord-000248-zueoyesj	789	13	channel	channel	NN
cord-000248-zueoyesj	789	14	water	water	NN
cord-000248-zueoyesj	789	15	,	,	,
cord-000248-zueoyesj	789	16	but	but	CC
cord-000248-zueoyesj	789	17	also	also	RB
cord-000248-zueoyesj	789	18	carbon	carbon	VBP
cord-000248-zueoyesj	789	19	dioxide	dioxide	NN
cord-000248-zueoyesj	789	20	and	and	CC
cord-000248-zueoyesj	789	21	ammonia	ammonia	NN
cord-000248-zueoyesj	789	22	[	[	-LRB-
cord-000248-zueoyesj	789	23	709	709	CD
cord-000248-zueoyesj	789	24	,	,	,
cord-000248-zueoyesj	789	25	710	710	CD
cord-000248-zueoyesj	789	26	,	,	,
cord-000248-zueoyesj	789	27	711	711	CD
cord-000248-zueoyesj	789	28	]	]	-RRB-
cord-000248-zueoyesj	789	29	,	,	,
cord-000248-zueoyesj	789	30	glycerol	glycerol	NN
cord-000248-zueoyesj	789	31	[	[	-LRB-
cord-000248-zueoyesj	789	32	712	712	CD
cord-000248-zueoyesj	789	33	]	]	-RRB-
cord-000248-zueoyesj	789	34	and	and	CC
cord-000248-zueoyesj	789	35	urea	urea	NN
cord-000248-zueoyesj	789	36	and	and	CC
cord-000248-zueoyesj	789	37	other	other	JJ
cord-000248-zueoyesj	789	38	small	small	JJ
cord-000248-zueoyesj	789	39	solutes	solute	NNS
cord-000248-zueoyesj	789	40	[	[	-LRB-
cord-000248-zueoyesj	789	41	713	713	CD
cord-000248-zueoyesj	789	42	]	]	-RRB-
cord-000248-zueoyesj	790	1	and	and	CC
cord-000248-zueoyesj	790	2	,	,	,
cord-000248-zueoyesj	790	3	very	very	RB
cord-000248-zueoyesj	790	4	relevant	relevant	JJ
cord-000248-zueoyesj	790	5	for	for	IN
cord-000248-zueoyesj	790	6	cancer	cancer	NN
cord-000248-zueoyesj	790	7	research	research	NN
cord-000248-zueoyesj	790	8	,	,	,
cord-000248-zueoyesj	790	9	hydrogen	hydrogen	NN
cord-000248-zueoyesj	790	10	peroxide	peroxide	NN
cord-000248-zueoyesj	790	11	[	[	-LRB-
cord-000248-zueoyesj	790	12	188	188	CD
cord-000248-zueoyesj	790	13	]	]	-RRB-
cord-000248-zueoyesj	790	14	.	.	.
cord-000248-zueoyesj	791	1	At	at	RB
cord-000248-zueoyesj	791	2	least	least	RBS
cord-000248-zueoyesj	791	3	two	two	CD
cord-000248-zueoyesj	791	4	of	of	IN
cord-000248-zueoyesj	791	5	members	member	NNS
cord-000248-zueoyesj	791	6	of	of	IN
cord-000248-zueoyesj	791	7	this	this	DT
cord-000248-zueoyesj	791	8	family	family	NN
cord-000248-zueoyesj	791	9	have	have	VBP
cord-000248-zueoyesj	791	10	been	be	VBN
cord-000248-zueoyesj	791	11	observed	observe	VBN
cord-000248-zueoyesj	791	12	in	in	IN
cord-000248-zueoyesj	791	13	the	the	DT
cord-000248-zueoyesj	791	14	inner	inner	JJ
cord-000248-zueoyesj	791	15	mitochondrial	mitochondrial	NN
cord-000248-zueoyesj	791	16	membrane	membrane	NN
cord-000248-zueoyesj	791	17	in	in	IN
cord-000248-zueoyesj	791	18	different	different	JJ
cord-000248-zueoyesj	791	19	tissues	tissue	NNS
cord-000248-zueoyesj	791	20	.	.	.
cord-000248-zueoyesj	792	1	This	this	DT
cord-000248-zueoyesj	792	2	in	in	IN
cord-000248-zueoyesj	792	3	turn	turn	NN
cord-000248-zueoyesj	792	4	may	may	MD
cord-000248-zueoyesj	792	5	indicate	indicate	VB
cord-000248-zueoyesj	792	6	mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	792	7	roles	role	NNS
cord-000248-zueoyesj	792	8	for	for	IN
cord-000248-zueoyesj	792	9	aquapotins	aquapotin	NNS
cord-000248-zueoyesj	792	10	in	in	IN
cord-000248-zueoyesj	792	11	osmotic	osmotic	JJ
cord-000248-zueoyesj	792	12	swelling	swelling	NN
cord-000248-zueoyesj	792	13	induced	induce	VBN
cord-000248-zueoyesj	792	14	by	by	IN
cord-000248-zueoyesj	792	15	apoptotic	apoptotic	JJ
cord-000248-zueoyesj	792	16	stimuli	stimulus	NNS
cord-000248-zueoyesj	792	17	[	[	-LRB-
cord-000248-zueoyesj	792	18	714	714	CD
cord-000248-zueoyesj	792	19	]	]	-RRB-
cord-000248-zueoyesj	792	20	.	.	.
cord-000248-zueoyesj	793	1	Could	Could	MD
cord-000248-zueoyesj	793	2	it	-PRON-	PRP
cord-000248-zueoyesj	793	3	be	be	VB
cord-000248-zueoyesj	793	4	possible	possible	JJ
cord-000248-zueoyesj	793	5	that	that	IN
cord-000248-zueoyesj	793	6	we	-PRON-	PRP
cord-000248-zueoyesj	793	7	can	can	MD
cord-000248-zueoyesj	793	8	track	track	VB
cord-000248-zueoyesj	793	9	cancer	cancer	NN
cord-000248-zueoyesj	793	10	progression	progression	NN
cord-000248-zueoyesj	793	11	by	by	IN
cord-000248-zueoyesj	793	12	looking	look	VBG
cord-000248-zueoyesj	793	13	at	at	IN
cord-000248-zueoyesj	793	14	some	some	DT
cord-000248-zueoyesj	793	15	of	of	IN
cord-000248-zueoyesj	793	16	these	these	DT
cord-000248-zueoyesj	793	17	'	'	''
cord-000248-zueoyesj	793	18	'	'	''
cord-000248-zueoyesj	793	19	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	793	20	demons	demon	NNS
cord-000248-zueoyesj	793	21	'	'	''
cord-000248-zueoyesj	793	22	'	'	''
cord-000248-zueoyesj	793	23	?	?	.
cord-000248-zueoyesj	794	1	We	-PRON-	PRP
cord-000248-zueoyesj	794	2	have	have	VBP
cord-000248-zueoyesj	794	3	seen	see	VBN
cord-000248-zueoyesj	794	4	in	in	IN
cord-000248-zueoyesj	794	5	Figure	Figure	NNP
cord-000248-zueoyesj	794	6	10	10	CD
cord-000248-zueoyesj	794	7	,	,	,
cord-000248-zueoyesj	794	8	that	that	IN
cord-000248-zueoyesj	794	9	AQP3	AQP3	NNP
cord-000248-zueoyesj	794	10	has	have	VBZ
cord-000248-zueoyesj	794	11	a	a	DT
cord-000248-zueoyesj	794	12	reduced	reduce	VBN
cord-000248-zueoyesj	794	13	expression	expression	NN
cord-000248-zueoyesj	794	14	with	with	IN
cord-000248-zueoyesj	794	15	increased	increase	VBN
cord-000248-zueoyesj	794	16	progression	progression	NN
cord-000248-zueoyesj	794	17	in	in	IN
cord-000248-zueoyesj	794	18	our	-PRON-	PRP$
cord-000248-zueoyesj	794	19	melanoma	melanoma	NN
cord-000248-zueoyesj	794	20	dataset	dataset	NN
cord-000248-zueoyesj	794	21	.	.	.
cord-000248-zueoyesj	795	1	Cao	Cao	NNP
cord-000248-zueoyesj	795	2	et	et	NNP
cord-000248-zueoyesj	795	3	al	al	NNP
cord-000248-zueoyesj	795	4	.	.	NNP
cord-000248-zueoyesj	795	5	,	,	,
cord-000248-zueoyesj	795	6	reported	report	VBD
cord-000248-zueoyesj	795	7	that	that	IN
cord-000248-zueoyesj	795	8	ultraviolet	ultraviolet	NN
cord-000248-zueoyesj	795	9	radiation	radiation	NN
cord-000248-zueoyesj	795	10	induced	induce	VBN
cord-000248-zueoyesj	795	11	AQP3	AQP3	NNP
cord-000248-zueoyesj	795	12	down	down	IN
cord-000248-zueoyesj	795	13	-	-	HYPH
cord-000248-zueoyesj	795	14	regulation	regulation	NN
cord-000248-zueoyesj	795	15	in	in	IN
cord-000248-zueoyesj	795	16	human	human	JJ
cord-000248-zueoyesj	795	17	karatinocytes	karatinocyte	NNS
cord-000248-zueoyesj	795	18	;	;	:
cord-000248-zueoyesj	795	19	thus	thus	RB
cord-000248-zueoyesj	795	20	AQP3	AQP3	NNP
cord-000248-zueoyesj	795	21	has	have	VBZ
cord-000248-zueoyesj	795	22	become	become	VBN
cord-000248-zueoyesj	795	23	a	a	DT
cord-000248-zueoyesj	795	24	strong	strong	JJ
cord-000248-zueoyesj	795	25	and	and	CC
cord-000248-zueoyesj	795	26	plausible	plausible	JJ
cord-000248-zueoyesj	795	27	link	link	NN
cord-000248-zueoyesj	795	28	between	between	IN
cord-000248-zueoyesj	795	29	UV	uv	NN
cord-000248-zueoyesj	795	30	radiation	radiation	NN
cord-000248-zueoyesj	795	31	,	,	,
cord-000248-zueoyesj	795	32	skin	skin	NN
cord-000248-zueoyesj	795	33	dehydration	dehydration	NN
cord-000248-zueoyesj	795	34	[	[	-LRB-
cord-000248-zueoyesj	795	35	186	186	CD
cord-000248-zueoyesj	795	36	,	,	,
cord-000248-zueoyesj	795	37	715	715	CD
cord-000248-zueoyesj	795	38	]	]	-RRB-
cord-000248-zueoyesj	795	39	and	and	CC
cord-000248-zueoyesj	795	40	photoaging	photoage	VBG
cord-000248-zueoyesj	795	41	[	[	-LRB-
cord-000248-zueoyesj	795	42	189	189	CD
cord-000248-zueoyesj	795	43	]	]	-RRB-
cord-000248-zueoyesj	795	44	.	.	.
cord-000248-zueoyesj	796	1	This	this	DT
cord-000248-zueoyesj	796	2	may	may	MD
cord-000248-zueoyesj	796	3	indicate	indicate	VB
cord-000248-zueoyesj	796	4	an	an	DT
cord-000248-zueoyesj	796	5	impared	impared	JJ
cord-000248-zueoyesj	796	6	function	function	NN
cord-000248-zueoyesj	796	7	on	on	IN
cord-000248-zueoyesj	796	8	skin	skin	NN
cord-000248-zueoyesj	796	9	hydration	hydration	NN
cord-000248-zueoyesj	796	10	[	[	-LRB-
cord-000248-zueoyesj	796	11	184	184	CD
cord-000248-zueoyesj	796	12	,	,	,
cord-000248-zueoyesj	796	13	185	185	CD
cord-000248-zueoyesj	796	14	,	,	,
cord-000248-zueoyesj	796	15	716	716	CD
cord-000248-zueoyesj	796	16	,	,	,
cord-000248-zueoyesj	796	17	717	717	CD
cord-000248-zueoyesj	796	18	,	,	,
cord-000248-zueoyesj	796	19	718	718	CD
cord-000248-zueoyesj	796	20	,	,	,
cord-000248-zueoyesj	796	21	719	719	CD
cord-000248-zueoyesj	796	22	]	]	-RRB-
cord-000248-zueoyesj	796	23	.	.	.
cord-000248-zueoyesj	797	1	The	the	DT
cord-000248-zueoyesj	797	2	expression	expression	NN
cord-000248-zueoyesj	797	3	of	of	IN
cord-000248-zueoyesj	797	4	AQP3	AQP3	NNP
cord-000248-zueoyesj	797	5	,	,	,
cord-000248-zueoyesj	797	6	as	as	RB
cord-000248-zueoyesj	797	7	well	well	RB
cord-000248-zueoyesj	797	8	as	as	IN
cord-000248-zueoyesj	797	9	AQP1	AQP1	NNP
cord-000248-zueoyesj	797	10	,	,	,
cord-000248-zueoyesj	797	11	AQP5	AQP5	NNP
cord-000248-zueoyesj	797	12	,	,	,
cord-000248-zueoyesj	797	13	and	and	CC
cord-000248-zueoyesj	797	14	AQP9	AQP9	NNPS
cord-000248-zueoyesj	797	15	seem	seem	VBP
cord-000248-zueoyesj	797	16	to	to	TO
cord-000248-zueoyesj	797	17	be	be	VB
cord-000248-zueoyesj	797	18	correlated	correlate	VBN
cord-000248-zueoyesj	797	19	with	with	IN
cord-000248-zueoyesj	797	20	melanoma	melanoma	NN
cord-000248-zueoyesj	797	21	progression	progression	NN
cord-000248-zueoyesj	797	22	,	,	,
cord-000248-zueoyesj	797	23	indicating	indicate	VBG
cord-000248-zueoyesj	797	24	a	a	DT
cord-000248-zueoyesj	797	25	common	common	JJ
cord-000248-zueoyesj	797	26	pattern	pattern	NN
cord-000248-zueoyesj	797	27	of	of	IN
cord-000248-zueoyesj	797	28	downregulation	downregulation	NN
cord-000248-zueoyesj	797	29	from	from	IN
cord-000248-zueoyesj	797	30	the	the	DT
cord-000248-zueoyesj	797	31	higher	high	JJR
cord-000248-zueoyesj	797	32	values	value	NNS
cord-000248-zueoyesj	797	33	in	in	IN
cord-000248-zueoyesj	797	34	normal	normal	JJ
cord-000248-zueoyesj	797	35	skin	skin	NN
cord-000248-zueoyesj	797	36	and	and	CC
cord-000248-zueoyesj	797	37	benign	benign	JJ
cord-000248-zueoyesj	797	38	nevi	nevus	NNS
cord-000248-zueoyesj	797	39	(	(	-LRB-
cord-000248-zueoyesj	797	40	see	see	VB
cord-000248-zueoyesj	797	41	Figure	Figure	NNP
cord-000248-zueoyesj	797	42	17	17	CD
cord-000248-zueoyesj	797	43	)	)	-RRB-
cord-000248-zueoyesj	797	44	.	.	.
cord-000248-zueoyesj	798	1	Does	do	VBZ
cord-000248-zueoyesj	798	2	a	a	DT
cord-000248-zueoyesj	798	3	similar	similar	JJ
cord-000248-zueoyesj	798	4	pattern	pattern	NN
cord-000248-zueoyesj	798	5	of	of	IN
cord-000248-zueoyesj	798	6	aquaporin	aquaporin	JJ
cord-000248-zueoyesj	798	7	downregulation	downregulation	NN
cord-000248-zueoyesj	798	8	exist	exist	VBP
cord-000248-zueoyesj	798	9	in	in	IN
cord-000248-zueoyesj	798	10	prostate	prostate	NN
cord-000248-zueoyesj	798	11	cancer	cancer	NN
cord-000248-zueoyesj	798	12	?	?	.
cord-000248-zueoyesj	799	1	Wang	Wang	NNP
cord-000248-zueoyesj	799	2	et	et	NNP
cord-000248-zueoyesj	799	3	al	al	NNP
cord-000248-zueoyesj	799	4	.	.	NNP
cord-000248-zueoyesj	799	5	have	have	VBP
cord-000248-zueoyesj	799	6	looked	look	VBN
cord-000248-zueoyesj	799	7	at	at	IN
cord-000248-zueoyesj	799	8	the	the	DT
cord-000248-zueoyesj	799	9	expression	expression	NN
cord-000248-zueoyesj	799	10	and	and	CC
cord-000248-zueoyesj	799	11	localization	localization	NN
cord-000248-zueoyesj	799	12	of	of	IN
cord-000248-zueoyesj	799	13	AQP3	AQP3	NNP
cord-000248-zueoyesj	799	14	in	in	IN
cord-000248-zueoyesj	799	15	human	human	JJ
cord-000248-zueoyesj	799	16	prostate	prostate	NN
cord-000248-zueoyesj	799	17	using	use	VBG
cord-000248-zueoyesj	799	18	cell	cell	NN
cord-000248-zueoyesj	799	19	lines	line	NNS
cord-000248-zueoyesj	799	20	as	as	RB
cord-000248-zueoyesj	799	21	well	well	RB
cord-000248-zueoyesj	799	22	as	as	IN
cord-000248-zueoyesj	799	23	patient	patient	JJ
cord-000248-zueoyesj	799	24	samples	sample	NNS
cord-000248-zueoyesj	799	25	.	.	.
cord-000248-zueoyesj	800	1	They	-PRON-	PRP
cord-000248-zueoyesj	800	2	have	have	VBP
cord-000248-zueoyesj	800	3	observed	observe	VBN
cord-000248-zueoyesj	801	1	AQP3	AQP3	NNP
cord-000248-zueoyesj	801	2	mRNA	mRNA	NNP
cord-000248-zueoyesj	801	3	'	'	''
cord-000248-zueoyesj	801	4	'	'	''
cord-000248-zueoyesj	801	5	in	in	IN
cord-000248-zueoyesj	801	6	both	both	CC
cord-000248-zueoyesj	801	7	normal	normal	JJ
cord-000248-zueoyesj	801	8	and	and	CC
cord-000248-zueoyesj	801	9	cancerous	cancerous	JJ
cord-000248-zueoyesj	801	10	epithelia	epithelium	NNS
cord-000248-zueoyesj	801	11	of	of	IN
cord-000248-zueoyesj	801	12	human	human	JJ
cord-000248-zueoyesj	801	13	prostate	prostate	NN
cord-000248-zueoyesj	801	14	tissues	tissue	NNS
cord-000248-zueoyesj	801	15	,	,	,
cord-000248-zueoyesj	801	16	but	but	CC
cord-000248-zueoyesj	801	17	not	not	RB
cord-000248-zueoyesj	801	18	in	in	IN
cord-000248-zueoyesj	801	19	the	the	DT
cord-000248-zueoyesj	801	20	mesenchyme	mesenchyme	NNS
cord-000248-zueoyesj	801	21	.	.	.
cord-000248-zueoyesj	802	1	In	in	IN
cord-000248-zueoyesj	802	2	the	the	DT
cord-000248-zueoyesj	802	3	normal	normal	JJ
cord-000248-zueoyesj	802	4	epithelia	epithelium	NNS
cord-000248-zueoyesj	802	5	of	of	IN
cord-000248-zueoyesj	802	6	the	the	DT
cord-000248-zueoyesj	802	7	prostate	prostate	NN
cord-000248-zueoyesj	802	8	,	,	,
cord-000248-zueoyesj	802	9	localization	localization	NN
cord-000248-zueoyesj	802	10	was	be	VBD
cord-000248-zueoyesj	802	11	limited	limit	VBN
cord-000248-zueoyesj	802	12	to	to	IN
cord-000248-zueoyesj	802	13	cell	cell	NN
cord-000248-zueoyesj	802	14	membranes	membrane	NNS
cord-000248-zueoyesj	802	15	,	,	,
cord-000248-zueoyesj	802	16	particularly	particularly	RB
cord-000248-zueoyesj	802	17	the	the	DT
cord-000248-zueoyesj	802	18	basolateral	basolateral	JJ
cord-000248-zueoyesj	802	19	membranes	membrane	NNS
cord-000248-zueoyesj	802	20	.	.	.
cord-000248-zueoyesj	803	1	However	however	RB
cord-000248-zueoyesj	803	2	,	,	,
cord-000248-zueoyesj	803	3	the	the	DT
cord-000248-zueoyesj	803	4	expression	expression	NN
cord-000248-zueoyesj	803	5	of	of	IN
cord-000248-zueoyesj	803	6	AQP3	AQP3	NNP
cord-000248-zueoyesj	803	7	protein	protein	NN
cord-000248-zueoyesj	803	8	in	in	IN
cord-000248-zueoyesj	803	9	the	the	DT
cord-000248-zueoyesj	803	10	cancer	cancer	NN
cord-000248-zueoyesj	803	11	epithelia	epithelium	NNS
cord-000248-zueoyesj	803	12	was	be	VBD
cord-000248-zueoyesj	803	13	not	not	RB
cord-000248-zueoyesj	803	14	observed	observe	VBN
cord-000248-zueoyesj	803	15	on	on	IN
cord-000248-zueoyesj	803	16	the	the	DT
cord-000248-zueoyesj	803	17	cell	cell	NN
cord-000248-zueoyesj	803	18	membranes	membrane	NNS
cord-000248-zueoyesj	803	19	.	.	.
cord-000248-zueoyesj	803	20	'	'	''
cord-000248-zueoyesj	803	21	'	'	''
cord-000248-zueoyesj	804	1	This	this	DT
cord-000248-zueoyesj	804	2	finding	finding	NN
cord-000248-zueoyesj	804	3	seems	seem	VBZ
cord-000248-zueoyesj	804	4	to	to	TO
cord-000248-zueoyesj	804	5	implicate	implicate	VB
cord-000248-zueoyesj	804	6	the	the	DT
cord-000248-zueoyesj	804	7	subcellular	subcellular	JJ
cord-000248-zueoyesj	804	8	localization	localization	NN
cord-000248-zueoyesj	804	9	of	of	IN
cord-000248-zueoyesj	804	10	AQP3	AQP3	NNP
cord-000248-zueoyesj	804	11	as	as	IN
cord-000248-zueoyesj	804	12	a	a	DT
cord-000248-zueoyesj	804	13	possible	possible	JJ
cord-000248-zueoyesj	804	14	indicator	indicator	NN
cord-000248-zueoyesj	804	15	of	of	IN
cord-000248-zueoyesj	804	16	a	a	DT
cord-000248-zueoyesj	804	17	transition	transition	NN
cord-000248-zueoyesj	804	18	to	to	IN
cord-000248-zueoyesj	804	19	a	a	DT
cord-000248-zueoyesj	804	20	more	more	RBR
cord-000248-zueoyesj	804	21	malignant	malignant	JJ
cord-000248-zueoyesj	804	22	phenotype	phenotype	NN
cord-000248-zueoyesj	804	23	.	.	.
cord-000248-zueoyesj	805	1	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	805	2	's	's	POS
cord-000248-zueoyesj	805	3	dataset	dataset	NN
cord-000248-zueoyesj	805	4	allows	allow	VBZ
cord-000248-zueoyesj	805	5	us	-PRON-	PRP
cord-000248-zueoyesj	805	6	to	to	TO
cord-000248-zueoyesj	805	7	see	see	VB
cord-000248-zueoyesj	805	8	the	the	DT
cord-000248-zueoyesj	805	9	downregulation	downregulation	NN
cord-000248-zueoyesj	805	10	of	of	IN
cord-000248-zueoyesj	805	11	AQP3	AQP3	NNP
cord-000248-zueoyesj	805	12	and	and	CC
cord-000248-zueoyesj	805	13	AQP1	AQP1	NNP
cord-000248-zueoyesj	805	14	.	.	.
cord-000248-zueoyesj	806	1	A	a	DT
cord-000248-zueoyesj	806	2	large	large	JJ
cord-000248-zueoyesj	806	3	subgroup	subgroup	NN
cord-000248-zueoyesj	806	4	of	of	IN
cord-000248-zueoyesj	806	5	primary	primary	JJ
cord-000248-zueoyesj	806	6	prostate	prostate	NN
cord-000248-zueoyesj	806	7	tumors	tumor	NNS
cord-000248-zueoyesj	806	8	has	have	VBZ
cord-000248-zueoyesj	806	9	reduced	reduce	VBN
cord-000248-zueoyesj	806	10	levels	level	NNS
cord-000248-zueoyesj	806	11	of	of	IN
cord-000248-zueoyesj	806	12	AQP3	AQP3	NNP
cord-000248-zueoyesj	806	13	and	and	CC
cord-000248-zueoyesj	806	14	AQP1	AQP1	NNP
cord-000248-zueoyesj	806	15	as	as	IN
cord-000248-zueoyesj	806	16	most	most	JJS
cord-000248-zueoyesj	806	17	of	of	IN
cord-000248-zueoyesj	806	18	the	the	DT
cord-000248-zueoyesj	806	19	lymph	lymph	NN
cord-000248-zueoyesj	806	20	node	node	NN
cord-000248-zueoyesj	806	21	metastasis	metastasis	NN
cord-000248-zueoyesj	806	22	samples	sample	NNS
cord-000248-zueoyesj	806	23	[	[	-LRB-
cord-000248-zueoyesj	806	24	Figure	figure	NN
cord-000248-zueoyesj	806	25	18	18	CD
cord-000248-zueoyesj	806	26	]	]	-RRB-
cord-000248-zueoyesj	806	27	.	.	.
cord-000248-zueoyesj	807	1	One	one	CD
cord-000248-zueoyesj	807	2	critique	critique	NN
cord-000248-zueoyesj	807	3	that	that	WDT
cord-000248-zueoyesj	807	4	we	-PRON-	PRP
cord-000248-zueoyesj	807	5	are	be	VBP
cord-000248-zueoyesj	807	6	aware	aware	JJ
cord-000248-zueoyesj	807	7	we	-PRON-	PRP
cord-000248-zueoyesj	807	8	could	could	MD
cord-000248-zueoyesj	807	9	receive	receive	VB
cord-000248-zueoyesj	807	10	is	be	VBZ
cord-000248-zueoyesj	807	11	that	that	IN
cord-000248-zueoyesj	807	12	the	the	DT
cord-000248-zueoyesj	807	13	current	current	JJ
cord-000248-zueoyesj	807	14	manuscript	manuscript	NN
cord-000248-zueoyesj	807	15	presents	present	VBZ
cord-000248-zueoyesj	807	16	a	a	DT
cord-000248-zueoyesj	807	17	novel	novel	NN
cord-000248-zueoyesj	807	18	methodology	methodology	NN
cord-000248-zueoyesj	807	19	and	and	CC
cord-000248-zueoyesj	807	20	an	an	DT
cord-000248-zueoyesj	807	21	underlying	underlie	VBG
cord-000248-zueoyesj	807	22	unifying	unifying	JJ
cord-000248-zueoyesj	807	23	theory	theory	NN
cord-000248-zueoyesj	807	24	based	base	VBN
cord-000248-zueoyesj	807	25	on	on	IN
cord-000248-zueoyesj	807	26	retrodictions	retrodiction	NNS
cord-000248-zueoyesj	807	27	or	or	CC
cord-000248-zueoyesj	807	28	postdictions	postdiction	NNS
cord-000248-zueoyesj	807	29	.	.	.
cord-000248-zueoyesj	808	1	Indeed	indeed	RB
cord-000248-zueoyesj	808	2	we	-PRON-	PRP
cord-000248-zueoyesj	808	3	have	have	VBP
cord-000248-zueoyesj	808	4	shown	show	VBN
cord-000248-zueoyesj	808	5	that	that	IN
cord-000248-zueoyesj	808	6	the	the	DT
cord-000248-zueoyesj	808	7	use	use	NN
cord-000248-zueoyesj	808	8	of	of	IN
cord-000248-zueoyesj	808	9	the	the	DT
cord-000248-zueoyesj	808	10	Normalized	Normalized	NNP
cord-000248-zueoyesj	808	11	Shannon	Shannon	NNP
cord-000248-zueoyesj	808	12	Entropy	Entropy	NNP
cord-000248-zueoyesj	808	13	and	and	CC
cord-000248-zueoyesj	808	14	the	the	DT
cord-000248-zueoyesj	808	15	Information	Information	NNP
cord-000248-zueoyesj	808	16	Theory	Theory	NNP
cord-000248-zueoyesj	808	17	quantifiers	quantifier	NNS
cord-000248-zueoyesj	808	18	(	(	-LRB-
cord-000248-zueoyesj	808	19	the	the	DT
cord-000248-zueoyesj	808	20	M	M	NNP
cord-000248-zueoyesj	808	21	-	-	HYPH
cord-000248-zueoyesj	808	22	complexities	complexity	NNS
cord-000248-zueoyesj	808	23	and	and	CC
cord-000248-zueoyesj	808	24	the	the	DT
cord-000248-zueoyesj	808	25	Jensen	Jensen	NNP
cord-000248-zueoyesj	808	26	-	-	HYPH
cord-000248-zueoyesj	808	27	Shannon	Shannon	NNP
cord-000248-zueoyesj	808	28	divergence	divergence	NN
cord-000248-zueoyesj	808	29	)	)	-RRB-
cord-000248-zueoyesj	808	30	allow	allow	VBP
cord-000248-zueoyesj	808	31	to	to	TO
cord-000248-zueoyesj	808	32	monitor	monitor	VB
cord-000248-zueoyesj	808	33	cancer	cancer	NN
cord-000248-zueoyesj	808	34	progression	progression	NN
cord-000248-zueoyesj	808	35	and	and	CC
cord-000248-zueoyesj	808	36	to	to	TO
cord-000248-zueoyesj	808	37	identify	identify	VB
cord-000248-zueoyesj	808	38	the	the	DT
cord-000248-zueoyesj	808	39	best	good	JJS
cord-000248-zueoyesj	808	40	biomarkers	biomarker	NNS
cord-000248-zueoyesj	808	41	that	that	WDT
cord-000248-zueoyesj	808	42	correlate	correlate	VBP
cord-000248-zueoyesj	808	43	with	with	IN
cord-000248-zueoyesj	808	44	the	the	DT
cord-000248-zueoyesj	808	45	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	808	46	changes	change	NNS
cord-000248-zueoyesj	808	47	.	.	.
cord-000248-zueoyesj	809	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	809	2	approach	approach	NN
cord-000248-zueoyesj	809	3	works	work	VBZ
cord-000248-zueoyesj	809	4	in	in	IN
cord-000248-zueoyesj	809	5	a	a	DT
cord-000248-zueoyesj	809	6	retrodiction	retrodiction	NN
cord-000248-zueoyesj	809	7	way	way	NN
cord-000248-zueoyesj	809	8	in	in	IN
cord-000248-zueoyesj	809	9	that	that	IN
cord-000248-zueoyesj	809	10	it	-PRON-	PRP
cord-000248-zueoyesj	809	11	looks	look	VBZ
cord-000248-zueoyesj	809	12	at	at	IN
cord-000248-zueoyesj	809	13	data	datum	NNS
cord-000248-zueoyesj	809	14	already	already	RB
cord-000248-zueoyesj	809	15	obtained	obtain	VBN
cord-000248-zueoyesj	809	16	by	by	IN
cord-000248-zueoyesj	809	17	other	other	JJ
cord-000248-zueoyesj	809	18	studies	study	NNS
cord-000248-zueoyesj	809	19	,	,	,
cord-000248-zueoyesj	809	20	but	but	CC
cord-000248-zueoyesj	809	21	gives	give	VBZ
cord-000248-zueoyesj	809	22	a	a	DT
cord-000248-zueoyesj	809	23	unifying	unifying	JJ
cord-000248-zueoyesj	809	24	framework	framework	NN
cord-000248-zueoyesj	809	25	to	to	TO
cord-000248-zueoyesj	809	26	track	track	VB
cord-000248-zueoyesj	809	27	cancer	cancer	NN
cord-000248-zueoyesj	809	28	progression	progression	NN
cord-000248-zueoyesj	809	29	.	.	.
cord-000248-zueoyesj	810	1	For	for	IN
cord-000248-zueoyesj	810	2	instance	instance	NN
cord-000248-zueoyesj	810	3	,	,	,
cord-000248-zueoyesj	810	4	on	on	IN
cord-000248-zueoyesj	810	5	True	True	NNP
cord-000248-zueoyesj	810	6	et	et	FW
cord-000248-zueoyesj	810	7	al	al	NNP
cord-000248-zueoyesj	810	8	's	's	POS
cord-000248-zueoyesj	810	9	dataset	dataset	NN
cord-000248-zueoyesj	810	10	,	,	,
cord-000248-zueoyesj	810	11	our	-PRON-	PRP$
cord-000248-zueoyesj	810	12	unifying	unifying	JJ
cord-000248-zueoyesj	810	13	hallmark	hallmark	NN
cord-000248-zueoyesj	810	14	of	of	IN
cord-000248-zueoyesj	810	15	cancer	cancer	NN
cord-000248-zueoyesj	810	16	gives	give	VBZ
cord-000248-zueoyesj	810	17	not	not	RB
cord-000248-zueoyesj	810	18	only	only	RB
cord-000248-zueoyesj	810	19	MAOA	MAOA	NNP
cord-000248-zueoyesj	810	20	,	,	,
cord-000248-zueoyesj	810	21	which	which	WDT
cord-000248-zueoyesj	810	22	was	be	VBD
cord-000248-zueoyesj	810	23	already	already	RB
cord-000248-zueoyesj	810	24	identified	identify	VBN
cord-000248-zueoyesj	810	25	in	in	IN
cord-000248-zueoyesj	810	26	the	the	DT
cord-000248-zueoyesj	810	27	original	original	JJ
cord-000248-zueoyesj	810	28	publication	publication	NN
cord-000248-zueoyesj	810	29	,	,	,
cord-000248-zueoyesj	810	30	but	but	CC
cord-000248-zueoyesj	810	31	also	also	RB
cord-000248-zueoyesj	810	32	AMACR	AMACR	NNP
cord-000248-zueoyesj	810	33	,	,	,
cord-000248-zueoyesj	810	34	CD40	CD40	NNP
cord-000248-zueoyesj	810	35	,	,	,
cord-000248-zueoyesj	810	36	CDK4	CDK4	NNP
cord-000248-zueoyesj	810	37	,	,	,
cord-000248-zueoyesj	810	38	etc	etc	FW
cord-000248-zueoyesj	810	39	.	.	.
cord-000248-zueoyesj	811	1	are	be	VBP
cord-000248-zueoyesj	811	2	very	very	RB
cord-000248-zueoyesj	811	3	important	important	JJ
cord-000248-zueoyesj	811	4	biomarkers	biomarker	NNS
cord-000248-zueoyesj	811	5	for	for	IN
cord-000248-zueoyesj	811	6	prostate	prostate	NN
cord-000248-zueoyesj	811	7	cancer	cancer	NN
cord-000248-zueoyesj	811	8	.	.	.
cord-000248-zueoyesj	812	1	Analogously	analogously	RB
cord-000248-zueoyesj	812	2	,	,	,
cord-000248-zueoyesj	812	3	the	the	DT
cord-000248-zueoyesj	812	4	identification	identification	NN
cord-000248-zueoyesj	812	5	of	of	IN
cord-000248-zueoyesj	812	6	KLK3	KLK3	NNP
cord-000248-zueoyesj	812	7	/	/	SYM
cord-000248-zueoyesj	812	8	PSA	PSA	NNP
cord-000248-zueoyesj	812	9	in	in	IN
cord-000248-zueoyesj	812	10	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	812	11	's	's	POS
cord-000248-zueoyesj	812	12	dataset	dataset	NN
cord-000248-zueoyesj	812	13	is	be	VBZ
cord-000248-zueoyesj	812	14	another	another	DT
cord-000248-zueoyesj	812	15	important	important	JJ
cord-000248-zueoyesj	812	16	retrodiction	retrodiction	NN
cord-000248-zueoyesj	812	17	which	which	WDT
cord-000248-zueoyesj	812	18	shows	show	VBZ
cord-000248-zueoyesj	812	19	the	the	DT
cord-000248-zueoyesj	812	20	power	power	NN
cord-000248-zueoyesj	812	21	of	of	IN
cord-000248-zueoyesj	812	22	the	the	DT
cord-000248-zueoyesj	812	23	method	method	NN
cord-000248-zueoyesj	812	24	.	.	.
cord-000248-zueoyesj	813	1	In	in	IN
cord-000248-zueoyesj	813	2	some	some	DT
cord-000248-zueoyesj	813	3	sense	sense	NN
cord-000248-zueoyesj	813	4	our	-PRON-	PRP$
cord-000248-zueoyesj	813	5	approach	approach	NN
cord-000248-zueoyesj	813	6	also	also	RB
cord-000248-zueoyesj	813	7	works	work	VBZ
cord-000248-zueoyesj	813	8	in	in	IN
cord-000248-zueoyesj	813	9	a	a	DT
cord-000248-zueoyesj	813	10	postdiction	postdiction	NN
cord-000248-zueoyesj	813	11	way	way	NN
cord-000248-zueoyesj	813	12	,	,	,
cord-000248-zueoyesj	813	13	as	as	IN
cord-000248-zueoyesj	813	14	it	-PRON-	PRP
cord-000248-zueoyesj	813	15	helps	help	VBZ
cord-000248-zueoyesj	813	16	to	to	TO
cord-000248-zueoyesj	813	17	evaluate	evaluate	VB
cord-000248-zueoyesj	813	18	the	the	DT
cord-000248-zueoyesj	813	19	speculation	speculation	NN
cord-000248-zueoyesj	813	20	that	that	IN
cord-000248-zueoyesj	813	21	cancer	cancer	NN
cord-000248-zueoyesj	813	22	cells	cell	NNS
cord-000248-zueoyesj	813	23	have	have	VBP
cord-000248-zueoyesj	813	24	'	'	``
cord-000248-zueoyesj	813	25	'	'	''
cord-000248-zueoyesj	813	26	an	an	DT
cord-000248-zueoyesj	813	27	entropic	entropic	JJ
cord-000248-zueoyesj	813	28	devolution	devolution	NN
cord-000248-zueoyesj	813	29	'	'	''
cord-000248-zueoyesj	813	30	'	'	''
cord-000248-zueoyesj	813	31	.	.	.
cord-000248-zueoyesj	814	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	814	2	results	result	NNS
cord-000248-zueoyesj	814	3	show	show	VBP
cord-000248-zueoyesj	814	4	that	that	IN
cord-000248-zueoyesj	814	5	the	the	DT
cord-000248-zueoyesj	814	6	variations	variation	NNS
cord-000248-zueoyesj	814	7	of	of	IN
cord-000248-zueoyesj	814	8	Normalized	Normalized	NNP
cord-000248-zueoyesj	814	9	Shannon	Shannon	NNP
cord-000248-zueoyesj	814	10	Entropy	Entropy	NNP
cord-000248-zueoyesj	814	11	and	and	CC
cord-000248-zueoyesj	814	12	Jensen	Jensen	NNP
cord-000248-zueoyesj	814	13	-	-	HYPH
cord-000248-zueoyesj	814	14	Shannon	Shannon	NNP
cord-000248-zueoyesj	814	15	divergences	divergence	NNS
cord-000248-zueoyesj	814	16	indeed	indeed	RB
cord-000248-zueoyesj	814	17	give	give	VBP
cord-000248-zueoyesj	814	18	measurable	measurable	JJ
cord-000248-zueoyesj	814	19	changes	change	NNS
cord-000248-zueoyesj	814	20	,	,	,
cord-000248-zueoyesj	814	21	and	and	CC
cord-000248-zueoyesj	814	22	that	that	IN
cord-000248-zueoyesj	814	23	these	these	DT
cord-000248-zueoyesj	814	24	changes	change	NNS
cord-000248-zueoyesj	814	25	are	be	VBP
cord-000248-zueoyesj	814	26	related	relate	VBN
cord-000248-zueoyesj	814	27	to	to	IN
cord-000248-zueoyesj	814	28	important	important	JJ
cord-000248-zueoyesj	814	29	biomarkers	biomarker	NNS
cord-000248-zueoyesj	814	30	in	in	IN
cord-000248-zueoyesj	814	31	the	the	DT
cord-000248-zueoyesj	814	32	two	two	CD
cord-000248-zueoyesj	814	33	types	type	NNS
cord-000248-zueoyesj	814	34	of	of	IN
cord-000248-zueoyesj	814	35	cancer	cancer	NN
cord-000248-zueoyesj	814	36	studied	study	VBN
cord-000248-zueoyesj	814	37	in	in	IN
cord-000248-zueoyesj	814	38	this	this	DT
cord-000248-zueoyesj	814	39	work	work	NN
cord-000248-zueoyesj	814	40	.	.	.
cord-000248-zueoyesj	815	1	In	in	IN
cord-000248-zueoyesj	815	2	addition	addition	NN
cord-000248-zueoyesj	815	3	,	,	,
cord-000248-zueoyesj	815	4	we	-PRON-	PRP
cord-000248-zueoyesj	815	5	remark	remark	VBP
cord-000248-zueoyesj	815	6	that	that	IN
cord-000248-zueoyesj	815	7	we	-PRON-	PRP
cord-000248-zueoyesj	815	8	are	be	VBP
cord-000248-zueoyesj	815	9	literally	literally	RB
cord-000248-zueoyesj	815	10	making	make	VBG
cord-000248-zueoyesj	815	11	hundreds	hundred	NNS
cord-000248-zueoyesj	815	12	,	,	,
cord-000248-zueoyesj	815	13	or	or	CC
cord-000248-zueoyesj	815	14	even	even	RB
cord-000248-zueoyesj	815	15	thousands	thousand	NNS
cord-000248-zueoyesj	815	16	of	of	IN
cord-000248-zueoyesj	815	17	predictions	prediction	NNS
cord-000248-zueoyesj	815	18	.	.	.
cord-000248-zueoyesj	816	1	The	the	DT
cord-000248-zueoyesj	816	2	results	result	NNS
cord-000248-zueoyesj	816	3	in	in	IN
cord-000248-zueoyesj	816	4	the	the	DT
cord-000248-zueoyesj	816	5	'	'	``
cord-000248-zueoyesj	816	6	Supplementary	Supplementary	NNP
cord-000248-zueoyesj	816	7	Material	Material	NNP
cord-000248-zueoyesj	816	8	'	'	''
cord-000248-zueoyesj	816	9	provide	provide	VB
cord-000248-zueoyesj	816	10	this	this	DT
cord-000248-zueoyesj	816	11	information	information	NN
cord-000248-zueoyesj	816	12	for	for	IN
cord-000248-zueoyesj	816	13	the	the	DT
cord-000248-zueoyesj	816	14	detailed	detailed	JJ
cord-000248-zueoyesj	816	15	scrutiny	scrutiny	NN
cord-000248-zueoyesj	816	16	of	of	IN
cord-000248-zueoyesj	816	17	our	-PRON-	PRP$
cord-000248-zueoyesj	816	18	peers	peer	NNS
cord-000248-zueoyesj	816	19	.	.	.
cord-000248-zueoyesj	817	1	We	-PRON-	PRP
cord-000248-zueoyesj	817	2	believe	believe	VBP
cord-000248-zueoyesj	817	3	that	that	IN
cord-000248-zueoyesj	817	4	other	other	JJ
cord-000248-zueoyesj	817	5	probes	probe	NNS
cord-000248-zueoyesj	817	6	with	with	IN
cord-000248-zueoyesj	817	7	gene	gene	NN
cord-000248-zueoyesj	817	8	expression	expression	NN
cord-000248-zueoyesj	817	9	patterns	pattern	NNS
cord-000248-zueoyesj	817	10	in	in	IN
cord-000248-zueoyesj	817	11	high	high	JJ
cord-000248-zueoyesj	817	12	correlation	correlation	NN
cord-000248-zueoyesj	817	13	with	with	IN
cord-000248-zueoyesj	817	14	the	the	DT
cord-000248-zueoyesj	817	15	probes	probe	NNS
cord-000248-zueoyesj	817	16	discussed	discuss	VBN
cord-000248-zueoyesj	817	17	in	in	IN
cord-000248-zueoyesj	817	18	this	this	DT
cord-000248-zueoyesj	817	19	paper	paper	NN
cord-000248-zueoyesj	817	20	,	,	,
cord-000248-zueoyesj	817	21	and	and	CC
cord-000248-zueoyesj	817	22	perhaps	perhaps	RB
cord-000248-zueoyesj	817	23	less	less	RBR
cord-000248-zueoyesj	817	24	studied	study	VBN
cord-000248-zueoyesj	817	25	by	by	IN
cord-000248-zueoyesj	817	26	immunohistochemistry	immunohistochemistry	NN
cord-000248-zueoyesj	817	27	and	and	CC
cord-000248-zueoyesj	817	28	other	other	JJ
cord-000248-zueoyesj	817	29	methods	method	NNS
cord-000248-zueoyesj	817	30	in	in	IN
cord-000248-zueoyesj	817	31	the	the	DT
cord-000248-zueoyesj	817	32	two	two	CD
cord-000248-zueoyesj	817	33	cancer	cancer	NN
cord-000248-zueoyesj	817	34	types	type	NNS
cord-000248-zueoyesj	817	35	studied	study	VBN
cord-000248-zueoyesj	817	36	here	here	RB
cord-000248-zueoyesj	817	37	,	,	,
cord-000248-zueoyesj	817	38	are	be	VBP
cord-000248-zueoyesj	817	39	worth	worth	JJ
cord-000248-zueoyesj	817	40	exploring	explore	VBG
cord-000248-zueoyesj	817	41	as	as	IN
cord-000248-zueoyesj	817	42	a	a	DT
cord-000248-zueoyesj	817	43	group	group	NN
cord-000248-zueoyesj	817	44	of	of	IN
cord-000248-zueoyesj	817	45	biomarkers	biomarker	NNS
cord-000248-zueoyesj	817	46	.	.	.
cord-000248-zueoyesj	818	1	These	these	DT
cord-000248-zueoyesj	818	2	predictions	prediction	NNS
cord-000248-zueoyesj	818	3	can	can	MD
cord-000248-zueoyesj	818	4	be	be	VB
cord-000248-zueoyesj	818	5	tested	test	VBN
cord-000248-zueoyesj	818	6	with	with	IN
cord-000248-zueoyesj	818	7	further	further	JJ
cord-000248-zueoyesj	818	8	studies	study	NNS
cord-000248-zueoyesj	818	9	on	on	IN
cord-000248-zueoyesj	818	10	staging	stage	VBG
cord-000248-zueoyesj	818	11	and	and	CC
cord-000248-zueoyesj	818	12	patient	patient	JJ
cord-000248-zueoyesj	818	13	stratification	stratification	NN
cord-000248-zueoyesj	818	14	.	.	.
cord-000248-zueoyesj	819	1	A	a	DT
cord-000248-zueoyesj	819	2	very	very	RB
cord-000248-zueoyesj	819	3	recent	recent	JJ
cord-000248-zueoyesj	819	4	study	study	NN
cord-000248-zueoyesj	819	5	by	by	IN
cord-000248-zueoyesj	819	6	Ballal	Ballal	NNP
cord-000248-zueoyesj	819	7	et	et	NNP
cord-000248-zueoyesj	819	8	al	al	NNP
cord-000248-zueoyesj	819	9	.	.	NNP
cord-000248-zueoyesj	819	10	have	have	VBP
cord-000248-zueoyesj	819	11	linked	link	VBN
cord-000248-zueoyesj	819	12	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	819	13	to	to	IN
cord-000248-zueoyesj	819	14	telomere	telomere	NN
cord-000248-zueoyesj	819	15	length	length	NN
cord-000248-zueoyesj	819	16	and	and	CC
cord-000248-zueoyesj	819	17	maintenance	maintenance	NN
cord-000248-zueoyesj	819	18	and	and	CC
cord-000248-zueoyesj	819	19	its	-PRON-	PRP$
cord-000248-zueoyesj	819	20	loss	loss	NN
cord-000248-zueoyesj	819	21	from	from	IN
cord-000248-zueoyesj	819	22	the	the	DT
cord-000248-zueoyesj	819	23	telomere	telomere	NN
cord-000248-zueoyesj	819	24	in	in	IN
cord-000248-zueoyesj	819	25	response	response	NN
cord-000248-zueoyesj	819	26	to	to	IN
cord-000248-zueoyesj	819	27	DNA	dna	NN
cord-000248-zueoyesj	819	28	damage	damage	NN
cord-000248-zueoyesj	819	29	[	[	-LRB-
cord-000248-zueoyesj	819	30	720	720	CD
cord-000248-zueoyesj	819	31	]	]	-RRB-
cord-000248-zueoyesj	820	1	(	(	-LRB-
cord-000248-zueoyesj	820	2	see	see	VB
cord-000248-zueoyesj	820	3	also	also	RB
cord-000248-zueoyesj	820	4	[	[	-LRB-
cord-000248-zueoyesj	820	5	721	721	CD
cord-000248-zueoyesj	820	6	]	]	-RRB-
cord-000248-zueoyesj	820	7	)	)	-RRB-
cord-000248-zueoyesj	820	8	.	.	.
cord-000248-zueoyesj	821	1	We	-PRON-	PRP
cord-000248-zueoyesj	821	2	have	have	VBP
cord-000248-zueoyesj	821	3	previously	previously	RB
cord-000248-zueoyesj	821	4	mentioned	mention	VBN
cord-000248-zueoyesj	821	5	that	that	IN
cord-000248-zueoyesj	821	6	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	821	7	is	be	VBZ
cord-000248-zueoyesj	821	8	a	a	DT
cord-000248-zueoyesj	821	9	conspiquous	conspiquous	JJ
cord-000248-zueoyesj	821	10	biomarker	biomarker	NN
cord-000248-zueoyesj	821	11	arising	arise	VBG
cord-000248-zueoyesj	821	12	from	from	IN
cord-000248-zueoyesj	821	13	the	the	DT
cord-000248-zueoyesj	821	14	analysis	analysis	NN
cord-000248-zueoyesj	821	15	of	of	IN
cord-000248-zueoyesj	821	16	True	True	NNP
cord-000248-zueoyesj	821	17	et	et	NNP
cord-000248-zueoyesj	821	18	al	al	NNP
cord-000248-zueoyesj	821	19	.	.	NNP
cord-000248-zueoyesj	821	20	's	's	POS
cord-000248-zueoyesj	821	21	dataset	dataset	NN
cord-000248-zueoyesj	821	22	using	use	VBG
cord-000248-zueoyesj	821	23	our	-PRON-	PRP$
cord-000248-zueoyesj	821	24	methods	method	NNS
cord-000248-zueoyesj	821	25	.	.	.
cord-000248-zueoyesj	822	1	We	-PRON-	PRP
cord-000248-zueoyesj	822	2	found	find	VBD
cord-000248-zueoyesj	822	3	this	this	DT
cord-000248-zueoyesj	822	4	to	to	TO
cord-000248-zueoyesj	822	5	correlate	correlate	VB
cord-000248-zueoyesj	822	6	with	with	IN
cord-000248-zueoyesj	822	7	a	a	DT
cord-000248-zueoyesj	822	8	preivous	preivous	JJ
cord-000248-zueoyesj	822	9	study	study	NN
cord-000248-zueoyesj	822	10	that	that	WDT
cord-000248-zueoyesj	822	11	showed	show	VBD
cord-000248-zueoyesj	822	12	that	that	IN
cord-000248-zueoyesj	822	13	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	822	14	has	have	VBZ
cord-000248-zueoyesj	822	15	a	a	DT
cord-000248-zueoyesj	822	16	reduced	reduce	VBN
cord-000248-zueoyesj	822	17	expression	expression	NN
cord-000248-zueoyesj	822	18	in	in	IN
cord-000248-zueoyesj	822	19	immortalized	immortalize	VBN
cord-000248-zueoyesj	822	20	prostate	prostate	NN
cord-000248-zueoyesj	822	21	epithelial	epithelial	JJ
cord-000248-zueoyesj	822	22	cells	cell	NNS
cord-000248-zueoyesj	822	23	before	before	IN
cord-000248-zueoyesj	822	24	and	and	CC
cord-000248-zueoyesj	822	25	after	after	IN
cord-000248-zueoyesj	822	26	their	-PRON-	PRP$
cord-000248-zueoyesj	822	27	conversion	conversion	NN
cord-000248-zueoyesj	822	28	to	to	IN
cord-000248-zueoyesj	822	29	tumorigenicity	tumorigenicity	NN
cord-000248-zueoyesj	822	30	[	[	-LRB-
cord-000248-zueoyesj	822	31	493	493	CD
cord-000248-zueoyesj	822	32	]	]	-RRB-
cord-000248-zueoyesj	822	33	.	.	.
cord-000248-zueoyesj	823	1	We	-PRON-	PRP
cord-000248-zueoyesj	823	2	also	also	RB
cord-000248-zueoyesj	823	3	mentioned	mention	VBD
cord-000248-zueoyesj	823	4	that	that	IN
cord-000248-zueoyesj	823	5	the	the	DT
cord-000248-zueoyesj	823	6	knockdown	knockdown	NN
cord-000248-zueoyesj	823	7	of	of	IN
cord-000248-zueoyesj	823	8	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	823	9	leads	lead	VBZ
cord-000248-zueoyesj	823	10	to	to	IN
cord-000248-zueoyesj	823	11	anaccumulation	anaccumulation	NN
cord-000248-zueoyesj	823	12	of	of	IN
cord-000248-zueoyesj	823	13	multinucleated	multinucleate	VBN
cord-000248-zueoyesj	823	14	cells	cell	NNS
cord-000248-zueoyesj	823	15	[	[	-LRB-
cord-000248-zueoyesj	823	16	492	492	CD
cord-000248-zueoyesj	823	17	]	]	-RRB-
cord-000248-zueoyesj	823	18	,	,	,
cord-000248-zueoyesj	823	19	preserving	preserve	VBG
cord-000248-zueoyesj	823	20	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	823	21	stability	stability	NN
cord-000248-zueoyesj	823	22	[	[	-LRB-
cord-000248-zueoyesj	823	23	490	490	CD
cord-000248-zueoyesj	823	24	]	]	-RRB-
cord-000248-zueoyesj	823	25	.	.	.
cord-000248-zueoyesj	824	1	Ballal	Ballal	NNP
cord-000248-zueoyesj	824	2	et	et	FW
cord-000248-zueoyesj	824	3	al	al	NNP
cord-000248-zueoyesj	824	4	.	.	.
cord-000248-zueoyesj	825	1	telomeric	telomeric	NNP
cord-000248-zueoyesj	825	2	ChIP	ChIP	NNP
cord-000248-zueoyesj	825	3	assays	assay	NNS
cord-000248-zueoyesj	825	4	to	to	TO
cord-000248-zueoyesj	825	5	detect	detect	VB
cord-000248-zueoyesj	825	6	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	825	7	at	at	IN
cord-000248-zueoyesj	825	8	the	the	DT
cord-000248-zueoyesj	825	9	telomere	telomere	NN
cord-000248-zueoyesj	825	10	and	and	CC
cord-000248-zueoyesj	825	11	reported	report	VBD
cord-000248-zueoyesj	825	12	time	time	NN
cord-000248-zueoyesj	825	13	-	-	HYPH
cord-000248-zueoyesj	825	14	dependent	dependent	JJ
cord-000248-zueoyesj	825	15	loss	loss	NN
cord-000248-zueoyesj	825	16	of	of	IN
cord-000248-zueoyesj	825	17	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	825	18	from	from	IN
cord-000248-zueoyesj	825	19	the	the	DT
cord-000248-zueoyesj	825	20	telomere	telomere	NN
cord-000248-zueoyesj	825	21	following	follow	VBG
cord-000248-zueoyesj	825	22	DNA	dna	NN
cord-000248-zueoyesj	825	23	damage	damage	NN
cord-000248-zueoyesj	825	24	.	.	.
cord-000248-zueoyesj	826	1	Due	due	IN
cord-000248-zueoyesj	826	2	to	to	IN
cord-000248-zueoyesj	826	3	the	the	DT
cord-000248-zueoyesj	826	4	role	role	NN
cord-000248-zueoyesj	826	5	of	of	IN
cord-000248-zueoyesj	826	6	telomeres	telomere	NNS
cord-000248-zueoyesj	826	7	in	in	IN
cord-000248-zueoyesj	826	8	maintaining	maintain	VBG
cord-000248-zueoyesj	826	9	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	826	10	stability	stability	NN
cord-000248-zueoyesj	826	11	[	[	-LRB-
cord-000248-zueoyesj	826	12	722	722	CD
cord-000248-zueoyesj	826	13	]	]	-RRB-
cord-000248-zueoyesj	826	14	and	and	CC
cord-000248-zueoyesj	826	15	the	the	DT
cord-000248-zueoyesj	826	16	inverse	inverse	JJ
cord-000248-zueoyesj	826	17	correlation	correlation	NN
cord-000248-zueoyesj	826	18	of	of	IN
cord-000248-zueoyesj	826	19	telomere	telomere	NN
cord-000248-zueoyesj	826	20	length	length	NN
cord-000248-zueoyesj	826	21	and	and	CC
cord-000248-zueoyesj	826	22	divergent	divergent	JJ
cord-000248-zueoyesj	826	23	karyotypes	karyotype	NNS
cord-000248-zueoyesj	826	24	in	in	IN
cord-000248-zueoyesj	826	25	prostate	prostate	NN
cord-000248-zueoyesj	826	26	cancer	cancer	NN
cord-000248-zueoyesj	826	27	cell	cell	NN
cord-000248-zueoyesj	826	28	lines	line	NNS
cord-000248-zueoyesj	826	29	[	[	-LRB-
cord-000248-zueoyesj	826	30	723	723	CD
cord-000248-zueoyesj	826	31	,	,	,
cord-000248-zueoyesj	826	32	724	724	CD
cord-000248-zueoyesj	826	33	]	]	-RRB-
cord-000248-zueoyesj	826	34	(	(	-LRB-
cord-000248-zueoyesj	826	35	as	as	RB
cord-000248-zueoyesj	826	36	well	well	RB
cord-000248-zueoyesj	826	37	as	as	IN
cord-000248-zueoyesj	826	38	the	the	DT
cord-000248-zueoyesj	826	39	recognized	recognize	VBN
cord-000248-zueoyesj	826	40	role	role	NN
cord-000248-zueoyesj	826	41	of	of	IN
cord-000248-zueoyesj	826	42	telomere	telomere	NN
cord-000248-zueoyesj	826	43	dysfunction	dysfunction	NN
cord-000248-zueoyesj	826	44	in	in	IN
cord-000248-zueoyesj	826	45	the	the	DT
cord-000248-zueoyesj	826	46	induction	induction	NN
cord-000248-zueoyesj	826	47	of	of	IN
cord-000248-zueoyesj	826	48	apoptosis	apoptosis	NN
cord-000248-zueoyesj	826	49	or	or	CC
cord-000248-zueoyesj	826	50	senescence	senescence	NN
cord-000248-zueoyesj	826	51	in	in	IN
cord-000248-zueoyesj	826	52	vivo	vivo	NN
cord-000248-zueoyesj	826	53	[	[	-LRB-
cord-000248-zueoyesj	826	54	725	725	CD
cord-000248-zueoyesj	826	55	,	,	,
cord-000248-zueoyesj	826	56	726	726	CD
cord-000248-zueoyesj	826	57	,	,	,
cord-000248-zueoyesj	826	58	727	727	CD
cord-000248-zueoyesj	826	59	,	,	,
cord-000248-zueoyesj	826	60	728	728	CD
cord-000248-zueoyesj	826	61	,	,	,
cord-000248-zueoyesj	826	62	729	729	CD
cord-000248-zueoyesj	826	63	,	,	,
cord-000248-zueoyesj	826	64	730	730	CD
cord-000248-zueoyesj	826	65	]	]	-RRB-
cord-000248-zueoyesj	826	66	,	,	,
cord-000248-zueoyesj	826	67	increase	increase	NN
cord-000248-zueoyesj	826	68	of	of	IN
cord-000248-zueoyesj	826	69	mutation	mutation	NN
cord-000248-zueoyesj	826	70	rates	rate	NNS
cord-000248-zueoyesj	826	71	[	[	-LRB-
cord-000248-zueoyesj	826	72	731	731	CD
cord-000248-zueoyesj	826	73	]	]	-RRB-
cord-000248-zueoyesj	826	74	,	,	,
cord-000248-zueoyesj	826	75	DNA	dna	NN
cord-000248-zueoyesj	826	76	fragmentation	fragmentation	NN
cord-000248-zueoyesj	826	77	[	[	-LRB-
cord-000248-zueoyesj	826	78	732	732	CD
cord-000248-zueoyesj	826	79	]	]	-RRB-
cord-000248-zueoyesj	826	80	,	,	,
cord-000248-zueoyesj	826	81	and	and	CC
cord-000248-zueoyesj	826	82	their	-PRON-	PRP$
cord-000248-zueoyesj	826	83	relation	relation	NN
cord-000248-zueoyesj	826	84	with	with	IN
cord-000248-zueoyesj	826	85	DNA	dna	NN
cord-000248-zueoyesj	826	86	damage	damage	NN
cord-000248-zueoyesj	826	87	signalling	signal	VBG
cord-000248-zueoyesj	826	88	[	[	-LRB-
cord-000248-zueoyesj	826	89	733	733	CD
cord-000248-zueoyesj	826	90	]	]	-RRB-
cord-000248-zueoyesj	826	91	)	)	-RRB-
cord-000248-zueoyesj	827	1	,	,	,
cord-000248-zueoyesj	827	2	we	-PRON-	PRP
cord-000248-zueoyesj	827	3	checked	check	VBD
cord-000248-zueoyesj	827	4	for	for	IN
cord-000248-zueoyesj	827	5	other	other	JJ
cord-000248-zueoyesj	827	6	probes	probe	NNS
cord-000248-zueoyesj	827	7	of	of	IN
cord-000248-zueoyesj	827	8	genes	gene	NNS
cord-000248-zueoyesj	827	9	involved	involve	VBN
cord-000248-zueoyesj	827	10	in	in	IN
cord-000248-zueoyesj	827	11	telomeric	telomeric	JJ
cord-000248-zueoyesj	827	12	function	function	NN
cord-000248-zueoyesj	827	13	.	.	.
cord-000248-zueoyesj	828	1	From	from	IN
cord-000248-zueoyesj	828	2	those	those	DT
cord-000248-zueoyesj	828	3	which	which	WDT
cord-000248-zueoyesj	828	4	we	-PRON-	PRP
cord-000248-zueoyesj	828	5	were	be	VBD
cord-000248-zueoyesj	828	6	able	able	JJ
cord-000248-zueoyesj	828	7	to	to	TO
cord-000248-zueoyesj	828	8	identify	identify	VB
cord-000248-zueoyesj	828	9	in	in	IN
cord-000248-zueoyesj	828	10	True	True	NNP
cord-000248-zueoyesj	828	11	et	et	NNP
cord-000248-zueoyesj	828	12	al	al	NNP
cord-000248-zueoyesj	828	13	's	's	POS
cord-000248-zueoyesj	828	14	dataset	dataset	NN
cord-000248-zueoyesj	828	15	,	,	,
cord-000248-zueoyesj	828	16	we	-PRON-	PRP
cord-000248-zueoyesj	828	17	have	have	VBP
cord-000248-zueoyesj	828	18	found	find	VBN
cord-000248-zueoyesj	828	19	a	a	DT
cord-000248-zueoyesj	828	20	strong	strong	JJ
cord-000248-zueoyesj	828	21	high	high	JJ
cord-000248-zueoyesj	828	22	correlation	correlation	NN
cord-000248-zueoyesj	828	23	of	of	IN
cord-000248-zueoyesj	828	24	the	the	DT
cord-000248-zueoyesj	828	25	expression	expression	NN
cord-000248-zueoyesj	828	26	of	of	IN
cord-000248-zueoyesj	828	27	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	828	28	with	with	IN
cord-000248-zueoyesj	828	29	TERF2	terf2	NN
cord-000248-zueoyesj	828	30	/	/	SYM
cord-000248-zueoyesj	828	31	TRF2	TRF2	NNP
cord-000248-zueoyesj	828	32	(	(	-LRB-
cord-000248-zueoyesj	828	33	telomeric	telomeric	JJ
cord-000248-zueoyesj	828	34	repeat	repeat	NN
cord-000248-zueoyesj	828	35	binding	bind	VBG
cord-000248-zueoyesj	828	36	factor	factor	NN
cord-000248-zueoyesj	828	37	2	2	CD
cord-000248-zueoyesj	828	38	)	)	-RRB-
cord-000248-zueoyesj	828	39	[	[	-LRB-
cord-000248-zueoyesj	828	40	734	734	CD
cord-000248-zueoyesj	828	41	]	]	-RRB-
cord-000248-zueoyesj	828	42	and	and	CC
cord-000248-zueoyesj	828	43	a	a	DT
cord-000248-zueoyesj	828	44	negative	negative	JJ
cord-000248-zueoyesj	828	45	correlation	correlation	NN
cord-000248-zueoyesj	828	46	with	with	IN
cord-000248-zueoyesj	828	47	the	the	DT
cord-000248-zueoyesj	828	48	expression	expression	NN
cord-000248-zueoyesj	828	49	pattern	pattern	NN
cord-000248-zueoyesj	828	50	of	of	IN
cord-000248-zueoyesj	828	51	TERF2IP	terf2ip	NN
cord-000248-zueoyesj	828	52	(	(	-LRB-
cord-000248-zueoyesj	828	53	telomeric	telomeric	JJ
cord-000248-zueoyesj	828	54	repeat	repeat	NN
cord-000248-zueoyesj	828	55	binding	bind	VBG
cord-000248-zueoyesj	828	56	factor	factor	NN
cord-000248-zueoyesj	828	57	2	2	CD
cord-000248-zueoyesj	828	58	,	,	,
cord-000248-zueoyesj	828	59	interacting	interact	VBG
cord-000248-zueoyesj	828	60	protein	protein	NN
cord-000248-zueoyesj	828	61	)	)	-RRB-
cord-000248-zueoyesj	829	1	[	[	-LRB-
cord-000248-zueoyesj	829	2	Figure	figure	NN
cord-000248-zueoyesj	829	3	19	19	CD
cord-000248-zueoyesj	829	4	]	]	-RRB-
cord-000248-zueoyesj	829	5	.	.	.
cord-000248-zueoyesj	830	1	Finally	finally	RB
cord-000248-zueoyesj	830	2	,	,	,
cord-000248-zueoyesj	830	3	one	one	CD
cord-000248-zueoyesj	830	4	particular	particular	JJ
cord-000248-zueoyesj	830	5	type	type	NN
cord-000248-zueoyesj	830	6	of	of	IN
cord-000248-zueoyesj	830	7	probes	probe	NNS
cord-000248-zueoyesj	830	8	has	have	VBZ
cord-000248-zueoyesj	830	9	also	also	RB
cord-000248-zueoyesj	830	10	caught	catch	VBN
cord-000248-zueoyesj	830	11	our	-PRON-	PRP$
cord-000248-zueoyesj	830	12	attention	attention	NN
cord-000248-zueoyesj	830	13	,	,	,
cord-000248-zueoyesj	830	14	and	and	CC
cord-000248-zueoyesj	830	15	we	-PRON-	PRP
cord-000248-zueoyesj	830	16	would	would	MD
cord-000248-zueoyesj	830	17	like	like	VB
cord-000248-zueoyesj	830	18	to	to	TO
cord-000248-zueoyesj	830	19	refer	refer	VB
cord-000248-zueoyesj	830	20	to	to	IN
cord-000248-zueoyesj	830	21	them	-PRON-	PRP
cord-000248-zueoyesj	830	22	before	before	IN
cord-000248-zueoyesj	830	23	concluding	conclude	VBG
cord-000248-zueoyesj	830	24	this	this	DT
cord-000248-zueoyesj	830	25	section	section	NN
cord-000248-zueoyesj	830	26	.	.	.
cord-000248-zueoyesj	831	1	With	with	IN
cord-000248-zueoyesj	831	2	the	the	DT
cord-000248-zueoyesj	831	3	denomination	denomination	NN
cord-000248-zueoyesj	831	4	of	of	IN
cord-000248-zueoyesj	831	5	'	'	``
cord-000248-zueoyesj	831	6	non	non	JJ
cord-000248-zueoyesj	831	7	-	-	JJ
cord-000248-zueoyesj	831	8	coding	coding	JJ
cord-000248-zueoyesj	831	9	RNA	rna	NN
cord-000248-zueoyesj	831	10	'	'	''
cord-000248-zueoyesj	831	11	we	-PRON-	PRP
cord-000248-zueoyesj	831	12	identify	identify	VBP
cord-000248-zueoyesj	831	13	those	those	DT
cord-000248-zueoyesj	831	14	RNA	RNA	NNP
cord-000248-zueoyesj	831	15	molecules	molecule	NNS
cord-000248-zueoyesj	831	16	which	which	WDT
cord-000248-zueoyesj	831	17	are	be	VBP
cord-000248-zueoyesj	831	18	functional	functional	JJ
cord-000248-zueoyesj	831	19	but	but	CC
cord-000248-zueoyesj	831	20	that	that	DT
cord-000248-zueoyesj	831	21	are	be	VBP
cord-000248-zueoyesj	831	22	not	not	RB
cord-000248-zueoyesj	831	23	translated	translate	VBN
cord-000248-zueoyesj	831	24	into	into	IN
cord-000248-zueoyesj	831	25	proteins	protein	NNS
cord-000248-zueoyesj	831	26	.	.	.
cord-000248-zueoyesj	832	1	Many	many	JJ
cord-000248-zueoyesj	832	2	microarray	microarray	NN
cord-000248-zueoyesj	832	3	chips	chip	NNS
cord-000248-zueoyesj	832	4	contain	contain	VBP
cord-000248-zueoyesj	832	5	probes	probe	NNS
cord-000248-zueoyesj	832	6	that	that	WDT
cord-000248-zueoyesj	832	7	are	be	VBP
cord-000248-zueoyesj	832	8	annotated	annotate	VBN
cord-000248-zueoyesj	832	9	as	as	IN
cord-000248-zueoyesj	832	10	'	'	``
cord-000248-zueoyesj	832	11	non	non	JJ
cord-000248-zueoyesj	832	12	-	-	JJ
cord-000248-zueoyesj	832	13	protein	protein	JJ
cord-000248-zueoyesj	832	14	coding	coding	NN
cord-000248-zueoyesj	832	15	'	'	''
cord-000248-zueoyesj	832	16	,	,	,
cord-000248-zueoyesj	832	17	indicating	indicate	VBG
cord-000248-zueoyesj	832	18	that	that	IN
cord-000248-zueoyesj	832	19	there	there	EX
cord-000248-zueoyesj	832	20	might	may	MD
cord-000248-zueoyesj	832	21	be	be	VB
cord-000248-zueoyesj	832	22	some	some	DT
cord-000248-zueoyesj	832	23	valuable	valuable	JJ
cord-000248-zueoyesj	832	24	expression	expression	NN
cord-000248-zueoyesj	832	25	data	datum	NNS
cord-000248-zueoyesj	832	26	that	that	WDT
cord-000248-zueoyesj	832	27	we	-PRON-	PRP
cord-000248-zueoyesj	832	28	can	can	MD
cord-000248-zueoyesj	832	29	also	also	RB
cord-000248-zueoyesj	832	30	mine	mine	VB
cord-000248-zueoyesj	832	31	for	for	IN
cord-000248-zueoyesj	832	32	information	information	NN
cord-000248-zueoyesj	832	33	.	.	.
cord-000248-zueoyesj	833	1	We	-PRON-	PRP
cord-000248-zueoyesj	833	2	note	note	VBP
cord-000248-zueoyesj	833	3	that	that	IN
cord-000248-zueoyesj	833	4	our	-PRON-	PRP$
cord-000248-zueoyesj	833	5	method	method	NN
cord-000248-zueoyesj	833	6	,	,	,
cord-000248-zueoyesj	833	7	although	although	IN
cord-000248-zueoyesj	833	8	employing	employ	VBG
cord-000248-zueoyesj	833	9	transcriptomic	transcriptomic	NNP
cord-000248-zueoyesj	833	10	data	datum	NNS
cord-000248-zueoyesj	833	11	,	,	,
cord-000248-zueoyesj	833	12	does	do	VBZ
cord-000248-zueoyesj	833	13	not	not	RB
cord-000248-zueoyesj	833	14	limit	limit	VB
cord-000248-zueoyesj	833	15	its	-PRON-	PRP$
cord-000248-zueoyesj	833	16	application	application	NN
cord-000248-zueoyesj	833	17	to	to	IN
cord-000248-zueoyesj	833	18	proteincoding	proteincode	VBG
cord-000248-zueoyesj	833	19	information	information	NN
cord-000248-zueoyesj	833	20	,	,	,
cord-000248-zueoyesj	833	21	and	and	CC
cord-000248-zueoyesj	833	22	that	that	IN
cord-000248-zueoyesj	833	23	the	the	DT
cord-000248-zueoyesj	833	24	combined	combine	VBN
cord-000248-zueoyesj	833	25	use	use	NN
cord-000248-zueoyesj	833	26	of	of	IN
cord-000248-zueoyesj	833	27	protein	protein	NN
cord-000248-zueoyesj	833	28	-	-	HYPH
cord-000248-zueoyesj	833	29	coding	code	VBG
cord-000248-zueoyesj	833	30	and	and	CC
cord-000248-zueoyesj	833	31	non	non	JJ
cord-000248-zueoyesj	833	32	-	-	JJ
cord-000248-zueoyesj	833	33	coding	coding	JJ
cord-000248-zueoyesj	833	34	protein	protein	NN
cord-000248-zueoyesj	833	35	probe	probe	NN
cord-000248-zueoyesj	833	36	expression	expression	NN
cord-000248-zueoyesj	833	37	would	would	MD
cord-000248-zueoyesj	833	38	allow	allow	VB
cord-000248-zueoyesj	833	39	a	a	DT
cord-000248-zueoyesj	833	40	more	more	RBR
cord-000248-zueoyesj	833	41	comprehensive	comprehensive	JJ
cord-000248-zueoyesj	833	42	view	view	NN
cord-000248-zueoyesj	833	43	of	of	IN
cord-000248-zueoyesj	833	44	the	the	DT
cord-000248-zueoyesj	833	45	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	833	46	state	state	NN
cord-000248-zueoyesj	833	47	of	of	IN
cord-000248-zueoyesj	833	48	the	the	DT
cord-000248-zueoyesj	833	49	cell	cell	NN
cord-000248-zueoyesj	833	50	.	.	.
cord-000248-zueoyesj	834	1	Among	among	IN
cord-000248-zueoyesj	834	2	non	non	JJ
cord-000248-zueoyesj	834	3	-	-	JJ
cord-000248-zueoyesj	834	4	protein	protein	JJ
cord-000248-zueoyesj	834	5	coding	coding	NN
cord-000248-zueoyesj	834	6	,	,	,
cord-000248-zueoyesj	834	7	microRNAs	microRNAs	NNPS
cord-000248-zueoyesj	834	8	[	[	-LRB-
cord-000248-zueoyesj	834	9	735	735	CD
cord-000248-zueoyesj	834	10	]	]	-RRB-
cord-000248-zueoyesj	834	11	are	be	VBP
cord-000248-zueoyesj	834	12	gaining	gain	VBG
cord-000248-zueoyesj	834	13	acceptance	acceptance	NN
cord-000248-zueoyesj	834	14	as	as	IN
cord-000248-zueoyesj	834	15	key	key	JJ
cord-000248-zueoyesj	834	16	players	player	NNS
cord-000248-zueoyesj	834	17	in	in	IN
cord-000248-zueoyesj	834	18	several	several	JJ
cord-000248-zueoyesj	834	19	cancers	cancer	NNS
cord-000248-zueoyesj	834	20	[	[	-LRB-
cord-000248-zueoyesj	834	21	736	736	CD
cord-000248-zueoyesj	834	22	,	,	,
cord-000248-zueoyesj	834	23	737	737	CD
cord-000248-zueoyesj	834	24	,	,	,
cord-000248-zueoyesj	834	25	738	738	CD
cord-000248-zueoyesj	834	26	]	]	-RRB-
cord-000248-zueoyesj	834	27	(	(	-LRB-
cord-000248-zueoyesj	834	28	including	include	VBG
cord-000248-zueoyesj	834	29	prostate	prostate	NN
cord-000248-zueoyesj	834	30	cancer	cancer	NN
cord-000248-zueoyesj	834	31	[	[	-LRB-
cord-000248-zueoyesj	834	32	739	739	CD
cord-000248-zueoyesj	834	33	,	,	,
cord-000248-zueoyesj	834	34	740	740	CD
cord-000248-zueoyesj	834	35	]	]	-RRB-
cord-000248-zueoyesj	834	36	)	)	-RRB-
cord-000248-zueoyesj	834	37	,	,	,
cord-000248-zueoyesj	834	38	but	but	CC
cord-000248-zueoyesj	834	39	the	the	DT
cord-000248-zueoyesj	834	40	so	so	RB
cord-000248-zueoyesj	834	41	-	-	HYPH
cord-000248-zueoyesj	834	42	called	call	VBN
cord-000248-zueoyesj	834	43	'	'	''
cord-000248-zueoyesj	834	44	'	'	``
cord-000248-zueoyesj	834	45	long	long	JJ
cord-000248-zueoyesj	834	46	noncoding	noncoding	JJ
cord-000248-zueoyesj	834	47	RNAs	rna	NNS
cord-000248-zueoyesj	834	48	'	'	POS
cord-000248-zueoyesj	834	49	'	'	''
cord-000248-zueoyesj	834	50	[	[	-LRB-
cord-000248-zueoyesj	834	51	741	741	CD
cord-000248-zueoyesj	834	52	]	]	-RRB-
cord-000248-zueoyesj	834	53	are	be	VBP
cord-000248-zueoyesj	834	54	also	also	RB
cord-000248-zueoyesj	834	55	gaining	gain	VBG
cord-000248-zueoyesj	834	56	a	a	DT
cord-000248-zueoyesj	834	57	place	place	NN
cord-000248-zueoyesj	834	58	in	in	IN
cord-000248-zueoyesj	834	59	the	the	DT
cord-000248-zueoyesj	834	60	scenario	scenario	NN
cord-000248-zueoyesj	834	61	of	of	IN
cord-000248-zueoyesj	834	62	cancer	cancer	NN
cord-000248-zueoyesj	834	63	biomarkers	biomarker	NNS
cord-000248-zueoyesj	834	64	(	(	-LRB-
cord-000248-zueoyesj	834	65	see	see	VB
cord-000248-zueoyesj	834	66	[	[	-LRB-
cord-000248-zueoyesj	834	67	742	742	CD
cord-000248-zueoyesj	834	68	]	]	-RRB-
cord-000248-zueoyesj	834	69	,	,	,
cord-000248-zueoyesj	834	70	and	and	CC
cord-000248-zueoyesj	834	71	[	[	-LRB-
cord-000248-zueoyesj	834	72	743	743	CD
cord-000248-zueoyesj	834	73	,	,	,
cord-000248-zueoyesj	834	74	744	744	CD
cord-000248-zueoyesj	834	75	,	,	,
cord-000248-zueoyesj	834	76	745	745	CD
cord-000248-zueoyesj	834	77	]	]	-RRB-
cord-000248-zueoyesj	834	78	)	)	-RRB-
cord-000248-zueoyesj	834	79	.	.	.
cord-000248-zueoyesj	835	1	We	-PRON-	PRP
cord-000248-zueoyesj	835	2	thus	thus	RB
cord-000248-zueoyesj	835	3	turned	turn	VBD
cord-000248-zueoyesj	835	4	our	-PRON-	PRP$
cord-000248-zueoyesj	835	5	attention	attention	NN
cord-000248-zueoyesj	835	6	to	to	IN
cord-000248-zueoyesj	835	7	these	these	DT
cord-000248-zueoyesj	835	8	probes	probe	NNS
cord-000248-zueoyesj	835	9	that	that	WDT
cord-000248-zueoyesj	835	10	have	have	VBP
cord-000248-zueoyesj	835	11	been	be	VBN
cord-000248-zueoyesj	835	12	annotated	annotate	VBN
cord-000248-zueoyesj	835	13	as	as	IN
cord-000248-zueoyesj	835	14	'	'	''
cord-000248-zueoyesj	835	15	'	'	``
cord-000248-zueoyesj	835	16	nonprotein	nonprotein	NNP
cord-000248-zueoyesj	835	17	coding	code	VBG
cord-000248-zueoyesj	835	18	'	'	''
cord-000248-zueoyesj	835	19	'	'	''
cord-000248-zueoyesj	835	20	and	and	CC
cord-000248-zueoyesj	835	21	we	-PRON-	PRP
cord-000248-zueoyesj	835	22	highlight	highlight	VBP
cord-000248-zueoyesj	835	23	some	some	DT
cord-000248-zueoyesj	835	24	of	of	IN
cord-000248-zueoyesj	835	25	them	-PRON-	PRP
cord-000248-zueoyesj	835	26	that	that	WDT
cord-000248-zueoyesj	835	27	have	have	VBP
cord-000248-zueoyesj	835	28	very	very	RB
cord-000248-zueoyesj	835	29	high	high	JJ
cord-000248-zueoyesj	835	30	correlation	correlation	NN
cord-000248-zueoyesj	835	31	values	value	NNS
cord-000248-zueoyesj	835	32	with	with	IN
cord-000248-zueoyesj	835	33	the	the	DT
cord-000248-zueoyesj	835	34	Normalized	Normalized	NNP
cord-000248-zueoyesj	835	35	Shannon	Shannon	NNP
cord-000248-zueoyesj	835	36	Entropy	Entropy	NNP
cord-000248-zueoyesj	835	37	in	in	IN
cord-000248-zueoyesj	835	38	True	True	NNP
cord-000248-zueoyesj	835	39	et	et	NNP
cord-000248-zueoyesj	835	40	al	al	NNP
cord-000248-zueoyesj	835	41	's	's	POS
cord-000248-zueoyesj	835	42	prostate	prostate	NN
cord-000248-zueoyesj	835	43	cancer	cancer	NN
cord-000248-zueoyesj	835	44	dataset	dataset	NN
cord-000248-zueoyesj	835	45	.	.	.
cord-000248-zueoyesj	836	1	In	in	IN
cord-000248-zueoyesj	836	2	particular	particular	JJ
cord-000248-zueoyesj	836	3	,	,	,
cord-000248-zueoyesj	836	4	the	the	DT
cord-000248-zueoyesj	836	5	probes	probe	NNS
cord-000248-zueoyesj	836	6	for	for	IN
cord-000248-zueoyesj	836	7	MALAT1/	malat1/	JJ
cord-000248-zueoyesj	836	8	MALAT-1	MALAT-1	NNP
cord-000248-zueoyesj	836	9	[	[	-LRB-
cord-000248-zueoyesj	836	10	742	742	CD
cord-000248-zueoyesj	836	11	,	,	,
cord-000248-zueoyesj	836	12	746	746	CD
cord-000248-zueoyesj	836	13	,	,	,
cord-000248-zueoyesj	836	14	747	747	CD
cord-000248-zueoyesj	836	15	,	,	,
cord-000248-zueoyesj	836	16	748	748	CD
cord-000248-zueoyesj	836	17	,	,	,
cord-000248-zueoyesj	836	18	749	749	CD
cord-000248-zueoyesj	836	19	,	,	,
cord-000248-zueoyesj	836	20	750	750	CD
cord-000248-zueoyesj	836	21	,	,	,
cord-000248-zueoyesj	836	22	751	751	CD
cord-000248-zueoyesj	836	23	,	,	,
cord-000248-zueoyesj	836	24	752	752	CD
cord-000248-zueoyesj	836	25	,	,	,
cord-000248-zueoyesj	836	26	753	753	CD
cord-000248-zueoyesj	836	27	,	,	,
cord-000248-zueoyesj	836	28	754	754	CD
cord-000248-zueoyesj	836	29	,	,	,
cord-000248-zueoyesj	836	30	755	755	CD
cord-000248-zueoyesj	836	31	,	,	,
cord-000248-zueoyesj	836	32	756	756	CD
cord-000248-zueoyesj	836	33	,	,	,
cord-000248-zueoyesj	836	34	757	757	CD
cord-000248-zueoyesj	836	35	,	,	,
cord-000248-zueoyesj	836	36	758	758	CD
cord-000248-zueoyesj	836	37	]	]	-RRB-
cord-000248-zueoyesj	836	38	have	have	VBP
cord-000248-zueoyesj	836	39	a	a	DT
cord-000248-zueoyesj	836	40	very	very	RB
cord-000248-zueoyesj	836	41	conspiquous	conspiquous	JJ
cord-000248-zueoyesj	836	42	position	position	NN
cord-000248-zueoyesj	836	43	(	(	-LRB-
cord-000248-zueoyesj	836	44	See	see	VB
cord-000248-zueoyesj	836	45	Figure	figure	NN
cord-000248-zueoyesj	836	46	20	20	CD
cord-000248-zueoyesj	836	47	)	)	-RRB-
cord-000248-zueoyesj	836	48	.	.	.
cord-000248-zueoyesj	837	1	They	-PRON-	PRP
cord-000248-zueoyesj	837	2	located	locate	VBD
cord-000248-zueoyesj	837	3	very	very	RB
cord-000248-zueoyesj	837	4	closely	closely	RB
cord-000248-zueoyesj	837	5	to	to	IN
cord-000248-zueoyesj	837	6	other	other	JJ
cord-000248-zueoyesj	837	7	protein	protein	NN
cord-000248-zueoyesj	837	8	coding	code	VBG
cord-000248-zueoyesj	837	9	biomarkers	biomarker	NNS
cord-000248-zueoyesj	837	10	that	that	WDT
cord-000248-zueoyesj	837	11	have	have	VBP
cord-000248-zueoyesj	837	12	also	also	RB
cord-000248-zueoyesj	837	13	lost	lose	VBN
cord-000248-zueoyesj	837	14	expression	expression	NN
cord-000248-zueoyesj	837	15	and	and	CC
cord-000248-zueoyesj	837	16	have	have	VBP
cord-000248-zueoyesj	837	17	been	be	VBN
cord-000248-zueoyesj	837	18	discussed	discuss	VBN
cord-000248-zueoyesj	837	19	in	in	IN
cord-000248-zueoyesj	837	20	this	this	DT
cord-000248-zueoyesj	837	21	work	work	NN
cord-000248-zueoyesj	837	22	like	like	IN
cord-000248-zueoyesj	837	23	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	837	24	,	,	,
cord-000248-zueoyesj	837	25	CD40	CD40	NNP
cord-000248-zueoyesj	837	26	,	,	,
cord-000248-zueoyesj	837	27	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	837	28	,	,	,
cord-000248-zueoyesj	837	29	and	and	CC
cord-000248-zueoyesj	837	30	TP53	TP53	NNP
cord-000248-zueoyesj	837	31	(	(	-LRB-
cord-000248-zueoyesj	837	32	see	see	VB
cord-000248-zueoyesj	837	33	Figure	Figure	NNP
cord-000248-zueoyesj	837	34	16	16	CD
cord-000248-zueoyesj	837	35	)	)	-RRB-
cord-000248-zueoyesj	837	36	.	.	.
cord-000248-zueoyesj	838	1	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	838	2	has	have	VBZ
cord-000248-zueoyesj	838	3	been	be	VBN
cord-000248-zueoyesj	838	4	recently	recently	RB
cord-000248-zueoyesj	838	5	pointed	point	VBN
cord-000248-zueoyesj	838	6	as	as	IN
cord-000248-zueoyesj	838	7	a	a	DT
cord-000248-zueoyesj	838	8	biomarker	biomarker	NN
cord-000248-zueoyesj	838	9	in	in	IN
cord-000248-zueoyesj	838	10	primary	primary	JJ
cord-000248-zueoyesj	838	11	human	human	JJ
cord-000248-zueoyesj	838	12	lobular	lobular	NNP
cord-000248-zueoyesj	838	13	breast	breast	NN
cord-000248-zueoyesj	838	14	cancer	cancer	NN
cord-000248-zueoyesj	838	15	as	as	IN
cord-000248-zueoyesj	838	16	a	a	DT
cord-000248-zueoyesj	838	17	result	result	NN
cord-000248-zueoyesj	838	18	of	of	IN
cord-000248-zueoyesj	838	19	an	an	DT
cord-000248-zueoyesj	838	20	analysis	analysis	NN
cord-000248-zueoyesj	838	21	of	of	IN
cord-000248-zueoyesj	838	22	over	over	IN
cord-000248-zueoyesj	838	23	132,000	132,000	CD
cord-000248-zueoyesj	838	24	Roche	Roche	NNP
cord-000248-zueoyesj	838	25	454	454	CD
cord-000248-zueoyesj	838	26	highconfidence	highconfidence	NN
cord-000248-zueoyesj	838	27	deep	deep	JJ
cord-000248-zueoyesj	838	28	sequencing	sequencing	NN
cord-000248-zueoyesj	838	29	reads	read	VBZ
cord-000248-zueoyesj	838	30	[	[	-LRB-
cord-000248-zueoyesj	838	31	749	749	CD
cord-000248-zueoyesj	838	32	]	]	-RRB-
cord-000248-zueoyesj	838	33	.	.	.
cord-000248-zueoyesj	839	1	An	an	DT
cord-000248-zueoyesj	839	2	international	international	JJ
cord-000248-zueoyesj	839	3	team	team	NN
cord-000248-zueoyesj	839	4	,	,	,
cord-000248-zueoyesj	839	5	searching	search	VBG
cord-000248-zueoyesj	839	6	on	on	IN
cord-000248-zueoyesj	839	7	thousands	thousand	NNS
cord-000248-zueoyesj	839	8	of	of	IN
cord-000248-zueoyesj	839	9	novel	novel	JJ
cord-000248-zueoyesj	839	10	non	non	JJ
cord-000248-zueoyesj	839	11	-	-	JJ
cord-000248-zueoyesj	839	12	coding	coding	JJ
cord-000248-zueoyesj	839	13	transcripts	transcript	NNS
cord-000248-zueoyesj	839	14	of	of	IN
cord-000248-zueoyesj	839	15	the	the	DT
cord-000248-zueoyesj	839	16	breast	breast	NN
cord-000248-zueoyesj	839	17	cancer	cancer	NN
cord-000248-zueoyesj	839	18	transcriptome	transcriptome	NN
cord-000248-zueoyesj	839	19	,	,	,
cord-000248-zueoyesj	839	20	has	have	VBZ
cord-000248-zueoyesj	839	21	been	be	VBN
cord-000248-zueoyesj	839	22	able	able	JJ
cord-000248-zueoyesj	839	23	to	to	TO
cord-000248-zueoyesj	839	24	identify	identify	VB
cord-000248-zueoyesj	839	25	more	more	JJR
cord-000248-zueoyesj	839	26	than	than	IN
cord-000248-zueoyesj	839	27	three	three	CD
cord-000248-zueoyesj	839	28	hundred	hundred	CD
cord-000248-zueoyesj	839	29	reads	read	VBZ
cord-000248-zueoyesj	839	30	corresponding	correspond	VBG
cord-000248-zueoyesj	839	31	to	to	IN
cord-000248-zueoyesj	839	32	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	839	33	[	[	-LRB-
cord-000248-zueoyesj	839	34	749	749	CD
cord-000248-zueoyesj	839	35	]	]	-RRB-
cord-000248-zueoyesj	839	36	.	.	.
cord-000248-zueoyesj	840	1	This	this	DT
cord-000248-zueoyesj	840	2	is	be	VBZ
cord-000248-zueoyesj	840	3	a	a	DT
cord-000248-zueoyesj	840	4	noncoding	noncoding	JJ
cord-000248-zueoyesj	840	5	RNA	rna	NN
cord-000248-zueoyesj	840	6	which	which	WDT
cord-000248-zueoyesj	840	7	was	be	VBD
cord-000248-zueoyesj	840	8	identified	identify	VBN
cord-000248-zueoyesj	840	9	in	in	IN
cord-000248-zueoyesj	840	10	2003	2003	CD
cord-000248-zueoyesj	840	11	in	in	IN
cord-000248-zueoyesj	840	12	non	non	JJ
cord-000248-zueoyesj	840	13	-	-	JJ
cord-000248-zueoyesj	840	14	small	small	JJ
cord-000248-zueoyesj	840	15	cell	cell	NN
cord-000248-zueoyesj	840	16	lung	lung	NN
cord-000248-zueoyesj	840	17	cancer	cancer	NN
cord-000248-zueoyesj	840	18	,	,	,
cord-000248-zueoyesj	840	19	was	be	VBD
cord-000248-zueoyesj	840	20	shown	show	VBN
cord-000248-zueoyesj	840	21	to	to	TO
cord-000248-zueoyesj	840	22	be	be	VB
cord-000248-zueoyesj	840	23	highly	highly	RB
cord-000248-zueoyesj	840	24	expressed	express	VBN
cord-000248-zueoyesj	840	25	(	(	-LRB-
cord-000248-zueoyesj	840	26	relative	relative	JJ
cord-000248-zueoyesj	840	27	to	to	IN
cord-000248-zueoyesj	840	28	GAPDH	GAPDH	NNP
cord-000248-zueoyesj	840	29	)	)	-RRB-
cord-000248-zueoyesj	840	30	in	in	IN
cord-000248-zueoyesj	840	31	lung	lung	NN
cord-000248-zueoyesj	840	32	,	,	,
cord-000248-zueoyesj	840	33	pancreas	pancreas	NN
cord-000248-zueoyesj	840	34	and	and	CC
cord-000248-zueoyesj	840	35	prostate	prostate	NN
cord-000248-zueoyesj	840	36	,	,	,
cord-000248-zueoyesj	840	37	but	but	CC
cord-000248-zueoyesj	840	38	not	not	RB
cord-000248-zueoyesj	840	39	in	in	IN
cord-000248-zueoyesj	840	40	other	other	JJ
cord-000248-zueoyesj	840	41	tissues	tissue	NNS
cord-000248-zueoyesj	840	42	including	include	VBG
cord-000248-zueoyesj	840	43	muscle	muscle	NN
cord-000248-zueoyesj	840	44	,	,	,
cord-000248-zueoyesj	840	45	skin	skin	NN
cord-000248-zueoyesj	840	46	,	,	,
cord-000248-zueoyesj	840	47	stomach	stomach	NN
cord-000248-zueoyesj	840	48	,	,	,
cord-000248-zueoyesj	840	49	bone	bone	NN
cord-000248-zueoyesj	840	50	marrow	marrow	NN
cord-000248-zueoyesj	840	51	,	,	,
cord-000248-zueoyesj	840	52	saliva	saliva	NN
cord-000248-zueoyesj	840	53	,	,	,
cord-000248-zueoyesj	840	54	thyroid	thyroid	NN
cord-000248-zueoyesj	840	55	and	and	CC
cord-000248-zueoyesj	840	56	adrenal	adrenal	JJ
cord-000248-zueoyesj	840	57	glands	gland	NNS
cord-000248-zueoyesj	840	58	,	,	,
cord-000248-zueoyesj	840	59	uterus	uterus	NN
cord-000248-zueoyesj	840	60	and	and	CC
cord-000248-zueoyesj	840	61	fetal	fetal	JJ
cord-000248-zueoyesj	840	62	liver	liver	NN
cord-000248-zueoyesj	840	63	[	[	-LRB-
cord-000248-zueoyesj	840	64	758	758	CD
cord-000248-zueoyesj	840	65	]	]	-RRB-
cord-000248-zueoyesj	840	66	.	.	.
cord-000248-zueoyesj	841	1	MALAT-1	MALAT-1	NNS
cord-000248-zueoyesj	841	2	,	,	,
cord-000248-zueoyesj	841	3	also	also	RB
cord-000248-zueoyesj	841	4	known	know	VBN
cord-000248-zueoyesj	841	5	as	as	IN
cord-000248-zueoyesj	841	6	NEAT2	NEAT2	NNS
cord-000248-zueoyesj	841	7	,	,	,
cord-000248-zueoyesj	841	8	is	be	VBZ
cord-000248-zueoyesj	841	9	considered	consider	VBN
cord-000248-zueoyesj	841	10	to	to	TO
cord-000248-zueoyesj	841	11	be	be	VB
cord-000248-zueoyesj	841	12	'	'	``
cord-000248-zueoyesj	841	13	'	'	''
cord-000248-zueoyesj	841	14	extraordinarily	extraordinarily	RB
cord-000248-zueoyesj	841	15	conseved	conseved	JJ
cord-000248-zueoyesj	841	16	for	for	IN
cord-000248-zueoyesj	841	17	a	a	DT
cord-000248-zueoyesj	841	18	noncoding	noncoding	JJ
cord-000248-zueoyesj	841	19	RNA	RNA	NNP
cord-000248-zueoyesj	841	20	,	,	,
cord-000248-zueoyesj	841	21	more	more	RBR
cord-000248-zueoyesj	841	22	so	so	RB
cord-000248-zueoyesj	841	23	than	than	IN
cord-000248-zueoyesj	841	24	even	even	RB
cord-000248-zueoyesj	841	25	XIST	XIST	NNP
cord-000248-zueoyesj	841	26	'	'	''
cord-000248-zueoyesj	841	27	'	'	''
cord-000248-zueoyesj	841	28	[	[	-LRB-
cord-000248-zueoyesj	841	29	754	754	CD
cord-000248-zueoyesj	841	30	]	]	-RRB-
cord-000248-zueoyesj	841	31	.	.	.
cord-000248-zueoyesj	842	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	842	2	results	result	NNS
cord-000248-zueoyesj	842	3	indicate	indicate	VBP
cord-000248-zueoyesj	842	4	that	that	IN
cord-000248-zueoyesj	842	5	the	the	DT
cord-000248-zueoyesj	842	6	reduction	reduction	NN
cord-000248-zueoyesj	842	7	of	of	IN
cord-000248-zueoyesj	842	8	expression	expression	NN
cord-000248-zueoyesj	842	9	of	of	IN
cord-000248-zueoyesj	842	10	some	some	DT
cord-000248-zueoyesj	842	11	non	non	JJ
cord-000248-zueoyesj	842	12	-	-	JJ
cord-000248-zueoyesj	842	13	coding	coding	JJ
cord-000248-zueoyesj	842	14	RNAs	rna	NNS
cord-000248-zueoyesj	842	15	,	,	,
cord-000248-zueoyesj	842	16	in	in	IN
cord-000248-zueoyesj	842	17	particular	particular	JJ
cord-000248-zueoyesj	842	18	of	of	IN
cord-000248-zueoyesj	842	19	MALAT-1	MALAT-1	NNS
cord-000248-zueoyesj	842	20	,	,	,
cord-000248-zueoyesj	842	21	and	and	CC
cord-000248-zueoyesj	842	22	SNORA60	SNORA60	NNP
cord-000248-zueoyesj	842	23	with	with	IN
cord-000248-zueoyesj	842	24	respect	respect	NN
cord-000248-zueoyesj	842	25	to	to	IN
cord-000248-zueoyesj	842	26	their	-PRON-	PRP$
cord-000248-zueoyesj	842	27	normal	normal	JJ
cord-000248-zueoyesj	842	28	expression	expression	NN
cord-000248-zueoyesj	842	29	in	in	IN
cord-000248-zueoyesj	842	30	prostate	prostate	NN
cord-000248-zueoyesj	842	31	,	,	,
cord-000248-zueoyesj	842	32	as	as	RB
cord-000248-zueoyesj	842	33	well	well	RB
cord-000248-zueoyesj	842	34	as	as	IN
cord-000248-zueoyesj	842	35	the	the	DT
cord-000248-zueoyesj	842	36	upregulation	upregulation	NN
cord-000248-zueoyesj	842	37	of	of	IN
cord-000248-zueoyesj	842	38	SNHG8	snhg8	NN
cord-000248-zueoyesj	843	1	and	and	CC
cord-000248-zueoyesj	843	2	SNHG1	SNHG1	NNP
cord-000248-zueoyesj	843	3	should	should	MD
cord-000248-zueoyesj	843	4	be	be	VB
cord-000248-zueoyesj	843	5	monitored	monitor	VBN
cord-000248-zueoyesj	843	6	as	as	IN
cord-000248-zueoyesj	843	7	useful	useful	JJ
cord-000248-zueoyesj	843	8	biomarkers	biomarker	NNS
cord-000248-zueoyesj	843	9	to	to	TO
cord-000248-zueoyesj	843	10	track	track	VB
cord-000248-zueoyesj	843	11	disease	disease	NN
cord-000248-zueoyesj	843	12	progression	progression	NN
cord-000248-zueoyesj	843	13	.	.	.
cord-000248-zueoyesj	844	1	We	-PRON-	PRP
cord-000248-zueoyesj	844	2	will	will	MD
cord-000248-zueoyesj	844	3	now	now	RB
cord-000248-zueoyesj	844	4	address	address	VB
cord-000248-zueoyesj	844	5	another	another	DT
cord-000248-zueoyesj	844	6	non	non	JJ
cord-000248-zueoyesj	844	7	-	-	JJ
cord-000248-zueoyesj	844	8	coding	coding	JJ
cord-000248-zueoyesj	844	9	RNA	RNA	NNP
cord-000248-zueoyesj	844	10	called	call	VBN
cord-000248-zueoyesj	844	11	NEAT1	neat1	NN
cord-000248-zueoyesj	844	12	which	which	WDT
cord-000248-zueoyesj	844	13	,	,	,
cord-000248-zueoyesj	844	14	like	like	IN
cord-000248-zueoyesj	844	15	NEAT2	NEAT2	NNS
cord-000248-zueoyesj	844	16	,	,	,
cord-000248-zueoyesj	844	17	is	be	VBZ
cord-000248-zueoyesj	844	18	also	also	RB
cord-000248-zueoyesj	844	19	conserved	conserve	VBN
cord-000248-zueoyesj	844	20	in	in	IN
cord-000248-zueoyesj	844	21	the	the	DT
cord-000248-zueoyesj	844	22	mammalian	mammalian	JJ
cord-000248-zueoyesj	844	23	lingeage	lingeage	NN
cord-000248-zueoyesj	844	24	.	.	.
cord-000248-zueoyesj	845	1	Before	before	IN
cord-000248-zueoyesj	845	2	we	-PRON-	PRP
cord-000248-zueoyesj	845	3	move	move	VBP
cord-000248-zueoyesj	845	4	onto	onto	IN
cord-000248-zueoyesj	845	5	NEAT1	neat1	NN
cord-000248-zueoyesj	845	6	,	,	,
cord-000248-zueoyesj	845	7	we	-PRON-	PRP
cord-000248-zueoyesj	845	8	will	will	MD
cord-000248-zueoyesj	845	9	first	first	RB
cord-000248-zueoyesj	845	10	recall	recall	VB
cord-000248-zueoyesj	845	11	a	a	DT
cord-000248-zueoyesj	845	12	previous	previous	JJ
cord-000248-zueoyesj	845	13	result	result	NN
cord-000248-zueoyesj	845	14	.	.	.
cord-000248-zueoyesj	846	1	We	-PRON-	PRP
cord-000248-zueoyesj	846	2	have	have	VBP
cord-000248-zueoyesj	846	3	noted	note	VBN
cord-000248-zueoyesj	846	4	before	before	IN
cord-000248-zueoyesj	846	5	the	the	DT
cord-000248-zueoyesj	846	6	conspiquous	conspiquous	JJ
cord-000248-zueoyesj	846	7	position	position	NN
cord-000248-zueoyesj	846	8	of	of	IN
cord-000248-zueoyesj	846	9	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	846	10	/	/	SYM
cord-000248-zueoyesj	846	11	PSF	PSF	NNP
cord-000248-zueoyesj	846	12	(	(	-LRB-
cord-000248-zueoyesj	846	13	Polypyrimidine	polypyrimidine	JJ
cord-000248-zueoyesj	846	14	tract	tract	NN
cord-000248-zueoyesj	846	15	-	-	HYPH
cord-000248-zueoyesj	846	16	binding	bind	VBG
cord-000248-zueoyesj	846	17	protein	protein	NN
cord-000248-zueoyesj	846	18	-	-	HYPH
cord-000248-zueoyesj	846	19	associated	associate	VBN
cord-000248-zueoyesj	846	20	splicing	splicing	NN
cord-000248-zueoyesj	846	21	factor	factor	NN
cord-000248-zueoyesj	846	22	)	)	-RRB-
cord-000248-zueoyesj	846	23	in	in	IN
cord-000248-zueoyesj	846	24	Figure	Figure	NNP
cord-000248-zueoyesj	846	25	16	16	CD
cord-000248-zueoyesj	846	26	.	.	.
cord-000248-zueoyesj	847	1	The	the	DT
cord-000248-zueoyesj	847	2	expression	expression	NN
cord-000248-zueoyesj	847	3	of	of	IN
cord-000248-zueoyesj	847	4	a	a	DT
cord-000248-zueoyesj	847	5	probe	probe	NN
cord-000248-zueoyesj	847	6	for	for	IN
cord-000248-zueoyesj	847	7	SPQF	SPQF	NNP
cord-000248-zueoyesj	847	8	has	have	VBZ
cord-000248-zueoyesj	847	9	the	the	DT
cord-000248-zueoyesj	847	10	highest	high	JJS
cord-000248-zueoyesj	847	11	correlation	correlation	NN
cord-000248-zueoyesj	847	12	with	with	IN
cord-000248-zueoyesj	847	13	the	the	DT
cord-000248-zueoyesj	847	14	values	value	NNS
cord-000248-zueoyesj	847	15	of	of	IN
cord-000248-zueoyesj	847	16	the	the	DT
cord-000248-zueoyesj	847	17	Normalized	Normalized	NNP
cord-000248-zueoyesj	847	18	Shannon	Shannon	NNP
cord-000248-zueoyesj	847	19	Entropy	Entropy	NNP
cord-000248-zueoyesj	847	20	.	.	.
cord-000248-zueoyesj	848	1	We	-PRON-	PRP
cord-000248-zueoyesj	848	2	highlighted	highlight	VBD
cord-000248-zueoyesj	848	3	before	before	IN
cord-000248-zueoyesj	848	4	that	that	DT
cord-000248-zueoyesj	848	5	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	848	6	/	/	SYM
cord-000248-zueoyesj	848	7	PSF	PSF	NNP
cord-000248-zueoyesj	848	8	is	be	VBZ
cord-000248-zueoyesj	848	9	a	a	DT
cord-000248-zueoyesj	848	10	putative	putative	JJ
cord-000248-zueoyesj	848	11	regulator	regulator	NN
cord-000248-zueoyesj	848	12	of	of	IN
cord-000248-zueoyesj	848	13	growth	growth	NN
cord-000248-zueoyesj	848	14	factor	factor	NN
cord-000248-zueoyesj	848	15	-	-	HYPH
cord-000248-zueoyesj	848	16	stimulated	stimulate	VBN
cord-000248-zueoyesj	848	17	gene	gene	NN
cord-000248-zueoyesj	848	18	expression	expression	NN
cord-000248-zueoyesj	848	19	[	[	-LRB-
cord-000248-zueoyesj	848	20	498	498	CD
cord-000248-zueoyesj	848	21	]	]	-RRB-
cord-000248-zueoyesj	848	22	.	.	.
cord-000248-zueoyesj	849	1	The	the	DT
cord-000248-zueoyesj	849	2	loss	loss	NN
cord-000248-zueoyesj	849	3	of	of	IN
cord-000248-zueoyesj	849	4	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	849	5	expression	expression	NN
cord-000248-zueoyesj	849	6	during	during	IN
cord-000248-zueoyesj	849	7	the	the	DT
cord-000248-zueoyesj	849	8	progression	progression	NN
cord-000248-zueoyesj	849	9	of	of	IN
cord-000248-zueoyesj	849	10	prostate	prostate	NN
cord-000248-zueoyesj	849	11	cancer	cancer	NN
cord-000248-zueoyesj	849	12	may	may	MD
cord-000248-zueoyesj	849	13	be	be	VB
cord-000248-zueoyesj	849	14	an	an	DT
cord-000248-zueoyesj	849	15	important	important	JJ
cord-000248-zueoyesj	849	16	key	key	NN
cord-000248-zueoyesj	849	17	to	to	TO
cord-000248-zueoyesj	849	18	understand	understand	VB
cord-000248-zueoyesj	849	19	this	this	DT
cord-000248-zueoyesj	849	20	disease	disease	NN
cord-000248-zueoyesj	849	21	or	or	CC
cord-000248-zueoyesj	849	22	one	one	CD
cord-000248-zueoyesj	849	23	of	of	IN
cord-000248-zueoyesj	849	24	its	-PRON-	PRP$
cord-000248-zueoyesj	849	25	subtypes	subtype	NNS
cord-000248-zueoyesj	849	26	.	.	.
cord-000248-zueoyesj	850	1	We	-PRON-	PRP
cord-000248-zueoyesj	850	2	have	have	VBP
cord-000248-zueoyesj	850	3	also	also	RB
cord-000248-zueoyesj	850	4	mentioned	mention	VBN
cord-000248-zueoyesj	850	5	that	that	IN
cord-000248-zueoyesj	850	6	the	the	DT
cord-000248-zueoyesj	850	7	AR	AR	NNP
cord-000248-zueoyesj	850	8	/	/	SYM
cord-000248-zueoyesj	850	9	PSF	PSF	NNP
cord-000248-zueoyesj	850	10	complex	complex	NN
cord-000248-zueoyesj	850	11	interacts	interact	VBZ
cord-000248-zueoyesj	850	12	with	with	IN
cord-000248-zueoyesj	850	13	the	the	DT
cord-000248-zueoyesj	850	14	PSA	PSA	NNP
cord-000248-zueoyesj	850	15	gene	gene	NN
cord-000248-zueoyesj	850	16	(	(	-LRB-
cord-000248-zueoyesj	850	17	perhaps	perhaps	RB
cord-000248-zueoyesj	850	18	the	the	DT
cord-000248-zueoyesj	850	19	most	most	RBS
cord-000248-zueoyesj	850	20	well	well	RB
cord-000248-zueoyesj	850	21	-	-	HYPH
cord-000248-zueoyesj	850	22	established	establish	VBN
cord-000248-zueoyesj	850	23	prostate	prostate	NN
cord-000248-zueoyesj	850	24	cancer	cancer	NN
cord-000248-zueoyesj	850	25	biomarker	biomarker	NN
cord-000248-zueoyesj	850	26	)	)	-RRB-
cord-000248-zueoyesj	850	27	and	and	CC
cord-000248-zueoyesj	850	28	that	that	IN
cord-000248-zueoyesj	850	29	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	850	30	/	/	SYM
cord-000248-zueoyesj	850	31	PSF	PSF	NNP
cord-000248-zueoyesj	850	32	inhibits	inhibit	VBZ
cord-000248-zueoyesj	850	33	AR	AR	NNP
cord-000248-zueoyesj	850	34	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	850	35	activity	activity	NN
cord-000248-zueoyesj	850	36	[	[	-LRB-
cord-000248-zueoyesj	850	37	499	499	CD
cord-000248-zueoyesj	850	38	]	]	-RRB-
cord-000248-zueoyesj	850	39	.	.	.
cord-000248-zueoyesj	851	1	Kuwahara	Kuwahara	NNP
cord-000248-zueoyesj	851	2	et	et	IN
cord-000248-zueoyesj	851	3	al	al	NNP
cord-000248-zueoyesj	851	4	.	.	.
cord-000248-zueoyesj	852	1	showed	show	VBD
cord-000248-zueoyesj	852	2	that	that	IN
cord-000248-zueoyesj	852	3	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	852	4	together	together	RB
cord-000248-zueoyesj	852	5	with	with	IN
cord-000248-zueoyesj	852	6	NONO	NONO	NNP
cord-000248-zueoyesj	852	7	(	(	-LRB-
cord-000248-zueoyesj	852	8	Non	Non	NNP
cord-000248-zueoyesj	852	9	-	-	JJ
cord-000248-zueoyesj	852	10	POU	pou	JJ
cord-000248-zueoyesj	852	11	-	-	HYPH
cord-000248-zueoyesj	852	12	domain	domain	NN
cord-000248-zueoyesj	852	13	-	-	HYPH
cord-000248-zueoyesj	852	14	containing	contain	VBG
cord-000248-zueoyesj	852	15	,	,	,
cord-000248-zueoyesj	852	16	octamer	octamer	NNP
cord-000248-zueoyesj	852	17	binding	bind	VBG
cord-000248-zueoyesj	852	18	protein	protein	NN
cord-000248-zueoyesj	852	19	)	)	-RRB-
cord-000248-zueoyesj	852	20	and	and	CC
cord-000248-zueoyesj	852	21	PSPC1	PSPC1	NNP
cord-000248-zueoyesj	853	1	(	(	-LRB-
cord-000248-zueoyesj	853	2	Paraspeckle	Paraspeckle	NNP
cord-000248-zueoyesj	853	3	protein	protein	NN
cord-000248-zueoyesj	853	4	1	1	CD
cord-000248-zueoyesj	853	5	alpha	alpha	NN
cord-000248-zueoyesj	853	6	isoform	isoform	NN
cord-000248-zueoyesj	853	7	,	,	,
cord-000248-zueoyesj	853	8	formerly	formerly	RB
cord-000248-zueoyesj	853	9	known	know	VBN
cord-000248-zueoyesj	853	10	as	as	IN
cord-000248-zueoyesj	853	11	PSP1	PSP1	NNP
cord-000248-zueoyesj	853	12	)	)	-RRB-
cord-000248-zueoyesj	853	13	are	be	VBP
cord-000248-zueoyesj	853	14	expressed	express	VBN
cord-000248-zueoyesj	853	15	in	in	IN
cord-000248-zueoyesj	853	16	mouse	mouse	NN
cord-000248-zueoyesj	853	17	Sertoli	Sertoli	NNP
cord-000248-zueoyesj	853	18	cells	cell	NNS
cord-000248-zueoyesj	853	19	of	of	IN
cord-000248-zueoyesj	853	20	the	the	DT
cord-000248-zueoyesj	853	21	testis	testis	NN
cord-000248-zueoyesj	853	22	and	and	CC
cord-000248-zueoyesj	853	23	form	form	NN
cord-000248-zueoyesj	853	24	complexes	complex	NNS
cord-000248-zueoyesj	853	25	that	that	WDT
cord-000248-zueoyesj	853	26	function	function	VBP
cord-000248-zueoyesj	853	27	as	as	IN
cord-000248-zueoyesj	853	28	coregulators	coregulator	NNS
cord-000248-zueoyesj	853	29	of	of	IN
cord-000248-zueoyesj	853	30	androgen	androgen	NN
cord-000248-zueoyesj	853	31	receptormediated	receptormediated	JJ
cord-000248-zueoyesj	853	32	transcription	transcription	NN
cord-000248-zueoyesj	853	33	[	[	-LRB-
cord-000248-zueoyesj	853	34	500	500	CD
cord-000248-zueoyesj	853	35	]	]	-RRB-
cord-000248-zueoyesj	853	36	.	.	.
cord-000248-zueoyesj	854	1	While	while	IN
cord-000248-zueoyesj	854	2	new	new	JJ
cord-000248-zueoyesj	854	3	research	research	NN
cord-000248-zueoyesj	854	4	results	result	NNS
cord-000248-zueoyesj	854	5	[	[	-LRB-
cord-000248-zueoyesj	854	6	759	759	CD
cord-000248-zueoyesj	854	7	]	]	-RRB-
cord-000248-zueoyesj	854	8	link	link	VBP
cord-000248-zueoyesj	854	9	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	854	10	and	and	CC
cord-000248-zueoyesj	854	11	NONO	NONO	NNP
cord-000248-zueoyesj	854	12	/	/	SYM
cord-000248-zueoyesj	854	13	P54NRB	P54NRB	VBN
cord-000248-zueoyesj	854	14	with	with	IN
cord-000248-zueoyesj	854	15	the	the	DT
cord-000248-zueoyesj	854	16	RAD51	RAD51	NNP
cord-000248-zueoyesj	854	17	family	family	NN
cord-000248-zueoyesj	854	18	of	of	IN
cord-000248-zueoyesj	854	19	proteins	protein	NNS
cord-000248-zueoyesj	854	20	(	(	-LRB-
cord-000248-zueoyesj	854	21	largely	largely	RB
cord-000248-zueoyesj	854	22	regarded	regard	VBN
cord-000248-zueoyesj	854	23	as	as	IN
cord-000248-zueoyesj	854	24	another	another	DT
cord-000248-zueoyesj	854	25	key	key	JJ
cord-000248-zueoyesj	854	26	protector	protector	NN
cord-000248-zueoyesj	854	27	of	of	IN
cord-000248-zueoyesj	854	28	chromosome	chromosome	NN
cord-000248-zueoyesj	854	29	integrity	integrity	NN
cord-000248-zueoyesj	854	30	as	as	IN
cord-000248-zueoyesj	854	31	being	be	VBG
cord-000248-zueoyesj	854	32	involved	involve	VBN
cord-000248-zueoyesj	854	33	in	in	IN
cord-000248-zueoyesj	854	34	homologous	homologous	JJ
cord-000248-zueoyesj	854	35	recombination	recombination	NN
cord-000248-zueoyesj	854	36	DNA	dna	NN
cord-000248-zueoyesj	854	37	repair	repair	NN
cord-000248-zueoyesj	854	38	)	)	-RRB-
cord-000248-zueoyesj	854	39	,	,	,
cord-000248-zueoyesj	854	40	it	-PRON-	PRP
cord-000248-zueoyesj	854	41	is	be	VBZ
cord-000248-zueoyesj	854	42	perhaps	perhaps	RB
cord-000248-zueoyesj	854	43	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	854	44	and	and	CC
cord-000248-zueoyesj	854	45	NONO	NONO	NNP
cord-000248-zueoyesj	854	46	's	's	POS
cord-000248-zueoyesj	854	47	co	co	NN
cord-000248-zueoyesj	854	48	-	-	NN
cord-000248-zueoyesj	854	49	localization	localization	NN
cord-000248-zueoyesj	854	50	in	in	IN
cord-000248-zueoyesj	854	51	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	854	52	that	that	WDT
cord-000248-zueoyesj	854	53	make	make	VBP
cord-000248-zueoyesj	854	54	this	this	DT
cord-000248-zueoyesj	854	55	group	group	NN
cord-000248-zueoyesj	854	56	also	also	RB
cord-000248-zueoyesj	854	57	remarkable	remarkable	JJ
cord-000248-zueoyesj	854	58	[	[	-LRB-
cord-000248-zueoyesj	854	59	760	760	CD
cord-000248-zueoyesj	854	60	]	]	-RRB-
cord-000248-zueoyesj	854	61	.	.	.
cord-000248-zueoyesj	855	1	Paraspeckles	Paraspeckles	NNP
cord-000248-zueoyesj	855	2	[	[	-LRB-
cord-000248-zueoyesj	855	3	760	760	CD
cord-000248-zueoyesj	855	4	,	,	,
cord-000248-zueoyesj	855	5	761	761	CD
cord-000248-zueoyesj	855	6	,	,	,
cord-000248-zueoyesj	855	7	762	762	CD
cord-000248-zueoyesj	855	8	,	,	,
cord-000248-zueoyesj	855	9	763	763	CD
cord-000248-zueoyesj	855	10	,	,	,
cord-000248-zueoyesj	855	11	764	764	CD
cord-000248-zueoyesj	855	12	,	,	,
cord-000248-zueoyesj	855	13	765	765	CD
cord-000248-zueoyesj	855	14	,	,	,
cord-000248-zueoyesj	855	15	766	766	CD
cord-000248-zueoyesj	855	16	,	,	,
cord-000248-zueoyesj	855	17	767	767	CD
cord-000248-zueoyesj	855	18	,	,	,
cord-000248-zueoyesj	855	19	768	768	CD
cord-000248-zueoyesj	855	20	,	,	,
cord-000248-zueoyesj	855	21	769	769	CD
cord-000248-zueoyesj	855	22	,	,	,
cord-000248-zueoyesj	855	23	770	770	CD
cord-000248-zueoyesj	855	24	,	,	,
cord-000248-zueoyesj	855	25	771	771	CD
cord-000248-zueoyesj	855	26	,	,	,
cord-000248-zueoyesj	855	27	772	772	CD
cord-000248-zueoyesj	855	28	,	,	,
cord-000248-zueoyesj	855	29	773	773	CD
cord-000248-zueoyesj	855	30	,	,	,
cord-000248-zueoyesj	855	31	774	774	CD
cord-000248-zueoyesj	855	32	,	,	,
cord-000248-zueoyesj	855	33	775	775	CD
cord-000248-zueoyesj	855	34	,	,	,
cord-000248-zueoyesj	855	35	776	776	CD
cord-000248-zueoyesj	855	36	,	,	,
cord-000248-zueoyesj	855	37	777	777	CD
cord-000248-zueoyesj	855	38	]	]	-RRB-
cord-000248-zueoyesj	855	39	are	be	VBP
cord-000248-zueoyesj	855	40	a	a	DT
cord-000248-zueoyesj	855	41	novel	novel	JJ
cord-000248-zueoyesj	855	42	nuclear	nuclear	JJ
cord-000248-zueoyesj	855	43	compartment	compartment	NN
cord-000248-zueoyesj	855	44	,	,	,
cord-000248-zueoyesj	855	45	of	of	IN
cord-000248-zueoyesj	855	46	approximately	approximately	RB
cord-000248-zueoyesj	855	47	0.2	0.2	CD
cord-000248-zueoyesj	855	48	-	-	SYM
cord-000248-zueoyesj	855	49	1	1	CD
cord-000248-zueoyesj	855	50	mm	mm	NN
cord-000248-zueoyesj	855	51	in	in	IN
cord-000248-zueoyesj	855	52	size	size	NN
cord-000248-zueoyesj	855	53	,	,	,
cord-000248-zueoyesj	855	54	discovered	discover	VBN
cord-000248-zueoyesj	855	55	in	in	IN
cord-000248-zueoyesj	855	56	2002	2002	CD
cord-000248-zueoyesj	855	57	,	,	,
cord-000248-zueoyesj	855	58	by	by	IN
cord-000248-zueoyesj	855	59	Fox	Fox	NNP
cord-000248-zueoyesj	855	60	et	et	FW
cord-000248-zueoyesj	855	61	al	al	NNP
cord-000248-zueoyesj	855	62	.	.	.
cord-000248-zueoyesj	856	1	in	in	IN
cord-000248-zueoyesj	856	2	Dundee	Dundee	NNP
cord-000248-zueoyesj	856	3	Scotland	Scotland	NNP
cord-000248-zueoyesj	856	4	,	,	,
cord-000248-zueoyesj	856	5	following	follow	VBG
cord-000248-zueoyesj	856	6	the	the	DT
cord-000248-zueoyesj	856	7	identification	identification	NN
cord-000248-zueoyesj	856	8	of	of	IN
cord-000248-zueoyesj	856	9	the	the	DT
cord-000248-zueoyesj	856	10	protein	protein	NN
cord-000248-zueoyesj	856	11	PSPC1	PSPC1	NNP
cord-000248-zueoyesj	856	12	(	(	-LRB-
cord-000248-zueoyesj	856	13	AF448795	af448795	JJ
cord-000248-zueoyesj	856	14	)	)	-RRB-
cord-000248-zueoyesj	856	15	in	in	IN
cord-000248-zueoyesj	856	16	the	the	DT
cord-000248-zueoyesj	856	17	nucleolar	nucleolar	NNP
cord-000248-zueoyesj	856	18	proteomics	proteomic	NNS
cord-000248-zueoyesj	856	19	project	project	NN
cord-000248-zueoyesj	856	20	at	at	IN
cord-000248-zueoyesj	856	21	Lamond	Lamond	NNP
cord-000248-zueoyesj	856	22	's	's	POS
cord-000248-zueoyesj	856	23	lab	lab	NN
cord-000248-zueoyesj	856	24	which	which	WDT
cord-000248-zueoyesj	856	25	is	be	VBZ
cord-000248-zueoyesj	856	26	described	describe	VBN
cord-000248-zueoyesj	856	27	well	well	RB
cord-000248-zueoyesj	856	28	by	by	IN
cord-000248-zueoyesj	856	29	Fox	Fox	NNP
cord-000248-zueoyesj	856	30	et	et	FW
cord-000248-zueoyesj	856	31	al	al	NNP
cord-000248-zueoyesj	856	32	.	.	.
cord-000248-zueoyesj	857	1	[	[	-LRB-
cord-000248-zueoyesj	857	2	777	777	CD
cord-000248-zueoyesj	857	3	]	]	-RRB-
cord-000248-zueoyesj	857	4	.	.	.
cord-000248-zueoyesj	858	1	Three	three	CD
cord-000248-zueoyesj	858	2	years	year	NNS
cord-000248-zueoyesj	858	3	later	later	RB
cord-000248-zueoyesj	858	4	,	,	,
cord-000248-zueoyesj	858	5	Fox	Fox	NNP
cord-000248-zueoyesj	858	6	,	,	,
cord-000248-zueoyesj	858	7	Bond	Bond	NNP
cord-000248-zueoyesj	858	8	and	and	CC
cord-000248-zueoyesj	858	9	Lamond	Lamond	NNP
cord-000248-zueoyesj	858	10	showed	show	VBD
cord-000248-zueoyesj	858	11	that	that	IN
cord-000248-zueoyesj	858	12	NONO	NONO	NNP
cord-000248-zueoyesj	858	13	and	and	CC
cord-000248-zueoyesj	858	14	PSPC1	PSPC1	NNP
cord-000248-zueoyesj	858	15	form	form	VBP
cord-000248-zueoyesj	858	16	a	a	DT
cord-000248-zueoyesj	858	17	heterodimer	heterodimer	NN
cord-000248-zueoyesj	858	18	that	that	WDT
cord-000248-zueoyesj	858	19	localizes	localize	VBZ
cord-000248-zueoyesj	858	20	to	to	IN
cord-000248-zueoyesj	858	21	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	858	22	in	in	IN
cord-000248-zueoyesj	858	23	an	an	DT
cord-000248-zueoyesj	858	24	RNA	RNA	NNP
cord-000248-zueoyesj	858	25	-	-	HYPH
cord-000248-zueoyesj	858	26	dependent	dependent	JJ
cord-000248-zueoyesj	858	27	manner	manner	NN
cord-000248-zueoyesj	858	28	[	[	-LRB-
cord-000248-zueoyesj	858	29	773	773	CD
cord-000248-zueoyesj	858	30	]	]	-RRB-
cord-000248-zueoyesj	858	31	.	.	.
cord-000248-zueoyesj	859	1	Paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	859	2	are	be	VBP
cord-000248-zueoyesj	859	3	dynamic	dynamic	JJ
cord-000248-zueoyesj	859	4	structures	structure	NNS
cord-000248-zueoyesj	859	5	,	,	,
cord-000248-zueoyesj	859	6	observed	observe	VBN
cord-000248-zueoyesj	859	7	in	in	IN
cord-000248-zueoyesj	859	8	numbers	number	NNS
cord-000248-zueoyesj	859	9	that	that	WDT
cord-000248-zueoyesj	859	10	vary	vary	VBP
cord-000248-zueoyesj	859	11	between	between	IN
cord-000248-zueoyesj	859	12	10	10	CD
cord-000248-zueoyesj	859	13	and	and	CC
cord-000248-zueoyesj	859	14	20	20	CD
cord-000248-zueoyesj	859	15	,	,	,
cord-000248-zueoyesj	859	16	that	that	WDT
cord-000248-zueoyesj	859	17	seem	seem	VBP
cord-000248-zueoyesj	859	18	to	to	TO
cord-000248-zueoyesj	859	19	control	control	VB
cord-000248-zueoyesj	859	20	gene	gene	NN
cord-000248-zueoyesj	859	21	expression	expression	NN
cord-000248-zueoyesj	859	22	via	via	IN
cord-000248-zueoyesj	859	23	retention	retention	NN
cord-000248-zueoyesj	859	24	of	of	IN
cord-000248-zueoyesj	859	25	RNA	RNA	NNP
cord-000248-zueoyesj	859	26	in	in	IN
cord-000248-zueoyesj	859	27	the	the	DT
cord-000248-zueoyesj	859	28	nucleus	nucleus	NN
cord-000248-zueoyesj	859	29	[	[	-LRB-
cord-000248-zueoyesj	859	30	772	772	CD
cord-000248-zueoyesj	859	31	]	]	-RRB-
cord-000248-zueoyesj	859	32	.	.	.
cord-000248-zueoyesj	860	1	A	a	DT
cord-000248-zueoyesj	860	2	long	long	JJ
cord-000248-zueoyesj	860	3	noncoding	noncoding	JJ
cord-000248-zueoyesj	860	4	RNA	RNA	NNP
cord-000248-zueoyesj	860	5	called	call	VBN
cord-000248-zueoyesj	860	6	NEAT1	NEAT1	NNP
cord-000248-zueoyesj	860	7	/	/	SYM
cord-000248-zueoyesj	860	8	MEN	men	NN
cord-000248-zueoyesj	860	9	epsilon	epsilon	NN
cord-000248-zueoyesj	861	1	/beta	/beta	NFP
cord-000248-zueoyesj	861	2	[	[	-LRB-
cord-000248-zueoyesj	861	3	754	754	CD
cord-000248-zueoyesj	861	4	,	,	,
cord-000248-zueoyesj	861	5	760	760	CD
cord-000248-zueoyesj	861	6	,	,	,
cord-000248-zueoyesj	861	7	762	762	CD
cord-000248-zueoyesj	861	8	,	,	,
cord-000248-zueoyesj	861	9	764	764	CD
cord-000248-zueoyesj	861	10	,	,	,
cord-000248-zueoyesj	861	11	778	778	CD
cord-000248-zueoyesj	861	12	]	]	-RRB-
cord-000248-zueoyesj	861	13	,	,	,
cord-000248-zueoyesj	861	14	that	that	WDT
cord-000248-zueoyesj	861	15	colocalizes	colocalizes	RB
cord-000248-zueoyesj	861	16	with	with	IN
cord-000248-zueoyesj	861	17	paraspeckles	paraspeckles	NNP
cord-000248-zueoyesj	861	18	,	,	,
cord-000248-zueoyesj	861	19	seems	seem	VBZ
cord-000248-zueoyesj	861	20	to	to	TO
cord-000248-zueoyesj	861	21	be	be	VB
cord-000248-zueoyesj	861	22	integral	integral	JJ
cord-000248-zueoyesj	861	23	to	to	IN
cord-000248-zueoyesj	861	24	their	-PRON-	PRP$
cord-000248-zueoyesj	861	25	structure	structure	NN
cord-000248-zueoyesj	861	26	.	.	.
cord-000248-zueoyesj	862	1	Depletion	depletion	NN
cord-000248-zueoyesj	862	2	of	of	IN
cord-000248-zueoyesj	862	3	NEAT1	NEAT1	NNP
cord-000248-zueoyesj	862	4	erradicates	erradicates	NNP
cord-000248-zueoyesj	862	5	paraspeckles	paraspeckles	NNP
cord-000248-zueoyesj	862	6	and	and	CC
cord-000248-zueoyesj	862	7	a	a	DT
cord-000248-zueoyesj	862	8	biochemical	biochemical	JJ
cord-000248-zueoyesj	862	9	analysis	analysis	NN
cord-000248-zueoyesj	862	10	by	by	IN
cord-000248-zueoyesj	862	11	Clemson	Clemson	NNP
cord-000248-zueoyesj	862	12	et	et	NNP
cord-000248-zueoyesj	862	13	al	al	NNP
cord-000248-zueoyesj	862	14	indicates	indicate	VBZ
cord-000248-zueoyesj	862	15	that	that	IN
cord-000248-zueoyesj	862	16	the	the	DT
cord-000248-zueoyesj	862	17	NEAT1	NEAT1	NNP
cord-000248-zueoyesj	862	18	binds	bind	VBZ
cord-000248-zueoyesj	862	19	with	with	IN
cord-000248-zueoyesj	862	20	paraspeckle	paraspeckle	NN
cord-000248-zueoyesj	862	21	proteins	protein	NNS
cord-000248-zueoyesj	863	1	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	863	2	/	/	SYM
cord-000248-zueoyesj	863	3	PSF	PSF	NNP
cord-000248-zueoyesj	863	4	,	,	,
cord-000248-zueoyesj	863	5	P54NRB	P54NRB	NNP
cord-000248-zueoyesj	863	6	/	/	SYM
cord-000248-zueoyesj	863	7	NONO	NONO	NNP
cord-000248-zueoyesj	863	8	and	and	CC
cord-000248-zueoyesj	863	9	PSPC1	PSPC1	NNS
cord-000248-zueoyesj	863	10	.	.	.
cord-000248-zueoyesj	864	1	NEAT1	NEAT1	NNP
cord-000248-zueoyesj	864	2	is	be	VBZ
cord-000248-zueoyesj	864	3	also	also	RB
cord-000248-zueoyesj	864	4	known	know	VBN
cord-000248-zueoyesj	864	5	as	as	IN
cord-000248-zueoyesj	864	6	TncRNA	TncRNA	NNP
cord-000248-zueoyesj	864	7	(	(	-LRB-
cord-000248-zueoyesj	864	8	trophoblast	trophoblast	NN
cord-000248-zueoyesj	864	9	-	-	HYPH
cord-000248-zueoyesj	864	10	derived	derive	VBN
cord-000248-zueoyesj	864	11	noncoding	noncoding	NNP
cord-000248-zueoyesj	864	12	RNA	RNA	NNP
cord-000248-zueoyesj	864	13	)	)	-RRB-
cord-000248-zueoyesj	864	14	[	[	-LRB-
cord-000248-zueoyesj	864	15	754	754	CD
cord-000248-zueoyesj	864	16	,	,	,
cord-000248-zueoyesj	864	17	779	779	CD
cord-000248-zueoyesj	864	18	,	,	,
cord-000248-zueoyesj	864	19	780	780	CD
cord-000248-zueoyesj	864	20	,	,	,
cord-000248-zueoyesj	864	21	781	781	CD
cord-000248-zueoyesj	864	22	,	,	,
cord-000248-zueoyesj	864	23	782	782	CD
cord-000248-zueoyesj	864	24	,	,	,
cord-000248-zueoyesj	864	25	783	783	CD
cord-000248-zueoyesj	864	26	,	,	,
cord-000248-zueoyesj	864	27	784	784	CD
cord-000248-zueoyesj	864	28	,	,	,
cord-000248-zueoyesj	864	29	785	785	CD
cord-000248-zueoyesj	864	30	,	,	,
cord-000248-zueoyesj	864	31	786	786	CD
cord-000248-zueoyesj	864	32	]	]	-RRB-
cord-000248-zueoyesj	864	33	and	and	CC
cord-000248-zueoyesj	864	34	probes	probe	NNS
cord-000248-zueoyesj	864	35	for	for	IN
cord-000248-zueoyesj	864	36	TncRNA	TncRNA	NNS
cord-000248-zueoyesj	864	37	exist	exist	VBP
cord-000248-zueoyesj	864	38	on	on	IN
cord-000248-zueoyesj	864	39	this	this	DT
cord-000248-zueoyesj	864	40	dataset	dataset	NN
cord-000248-zueoyesj	864	41	,	,	,
cord-000248-zueoyesj	864	42	We	-PRON-	PRP
cord-000248-zueoyesj	864	43	have	have	VBP
cord-000248-zueoyesj	864	44	observed	observe	VBN
cord-000248-zueoyesj	864	45	in	in	IN
cord-000248-zueoyesj	864	46	True	True	NNP
cord-000248-zueoyesj	864	47	et	et	NNP
cord-000248-zueoyesj	864	48	al	al	NNP
cord-000248-zueoyesj	864	49	.	.	NNP
cord-000248-zueoyesj	864	50	's	's	POS
cord-000248-zueoyesj	864	51	dataset	dataset	NN
cord-000248-zueoyesj	864	52	that	that	IN
cord-000248-zueoyesj	864	53	there	there	EX
cord-000248-zueoyesj	864	54	exists	exist	VBZ
cord-000248-zueoyesj	864	55	a	a	DT
cord-000248-zueoyesj	864	56	high	high	JJ
cord-000248-zueoyesj	864	57	correlation	correlation	NN
cord-000248-zueoyesj	864	58	between	between	IN
cord-000248-zueoyesj	864	59	the	the	DT
cord-000248-zueoyesj	864	60	Normalized	Normalized	NNP
cord-000248-zueoyesj	864	61	Shannon	Shannon	NNP
cord-000248-zueoyesj	864	62	Entropy	Entropy	NNP
cord-000248-zueoyesj	864	63	with	with	IN
cord-000248-zueoyesj	864	64	the	the	DT
cord-000248-zueoyesj	864	65	expression	expression	NN
cord-000248-zueoyesj	864	66	of	of	IN
cord-000248-zueoyesj	864	67	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	864	68	/	/	SYM
cord-000248-zueoyesj	864	69	PSF	PSF	NNP
cord-000248-zueoyesj	864	70	,	,	,
cord-000248-zueoyesj	864	71	P54NRB	P54NRB	NNP
cord-000248-zueoyesj	864	72	/	/	SYM
cord-000248-zueoyesj	864	73	NONO	NONO	NNP
cord-000248-zueoyesj	864	74	,	,	,
cord-000248-zueoyesj	864	75	and	and	CC
cord-000248-zueoyesj	864	76	TncRNA	TncRNA	NNP
cord-000248-zueoyesj	864	77	.	.	.
cord-000248-zueoyesj	865	1	Overall	overall	RB
cord-000248-zueoyesj	865	2	,	,	,
cord-000248-zueoyesj	865	3	this	this	DT
cord-000248-zueoyesj	865	4	implies	imply	VBZ
cord-000248-zueoyesj	865	5	that	that	IN
cord-000248-zueoyesj	865	6	the	the	DT
cord-000248-zueoyesj	865	7	disruption	disruption	NN
cord-000248-zueoyesj	865	8	of	of	IN
cord-000248-zueoyesj	865	9	the	the	DT
cord-000248-zueoyesj	865	10	function	function	NN
cord-000248-zueoyesj	865	11	of	of	IN
cord-000248-zueoyesj	865	12	the	the	DT
cord-000248-zueoyesj	865	13	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	865	14	is	be	VBZ
cord-000248-zueoyesj	865	15	correlated	correlate	VBN
cord-000248-zueoyesj	865	16	with	with	IN
cord-000248-zueoyesj	865	17	the	the	DT
cord-000248-zueoyesj	865	18	increasing	increase	VBG
cord-000248-zueoyesj	865	19	signs	sign	NNS
cord-000248-zueoyesj	865	20	of	of	IN
cord-000248-zueoyesj	865	21	deterioration	deterioration	NN
cord-000248-zueoyesj	865	22	of	of	IN
cord-000248-zueoyesj	865	23	normal	normal	JJ
cord-000248-zueoyesj	865	24	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	865	25	state	state	NN
cord-000248-zueoyesj	865	26	of	of	IN
cord-000248-zueoyesj	865	27	the	the	DT
cord-000248-zueoyesj	865	28	cells	cell	NNS
cord-000248-zueoyesj	865	29	.	.	.
cord-000248-zueoyesj	866	1	While	while	IN
cord-000248-zueoyesj	866	2	a	a	DT
cord-000248-zueoyesj	866	3	causal	causal	JJ
cord-000248-zueoyesj	866	4	relationship	relationship	NN
cord-000248-zueoyesj	866	5	still	still	RB
cord-000248-zueoyesj	866	6	needs	need	VBZ
cord-000248-zueoyesj	866	7	to	to	TO
cord-000248-zueoyesj	866	8	be	be	VB
cord-000248-zueoyesj	866	9	proved	prove	VBN
cord-000248-zueoyesj	866	10	,	,	,
cord-000248-zueoyesj	866	11	we	-PRON-	PRP
cord-000248-zueoyesj	866	12	admire	admire	VBP
cord-000248-zueoyesj	866	13	the	the	DT
cord-000248-zueoyesj	866	14	mathematical	mathematical	JJ
cord-000248-zueoyesj	866	15	elegance	elegance	NN
cord-000248-zueoyesj	866	16	of	of	IN
cord-000248-zueoyesj	866	17	the	the	DT
cord-000248-zueoyesj	866	18	Normalized	Normalized	NNP
cord-000248-zueoyesj	866	19	Shannon	Shannon	NNP
cord-000248-zueoyesj	866	20	Entropy	Entropy	NNP
cord-000248-zueoyesj	866	21	of	of	IN
cord-000248-zueoyesj	866	22	the	the	DT
cord-000248-zueoyesj	866	23	samples	sample	NNS
cord-000248-zueoyesj	866	24	,	,	,
cord-000248-zueoyesj	866	25	a	a	DT
cord-000248-zueoyesj	866	26	global	global	JJ
cord-000248-zueoyesj	866	27	measure	measure	NN
cord-000248-zueoyesj	866	28	of	of	IN
cord-000248-zueoyesj	866	29	the	the	DT
cord-000248-zueoyesj	866	30	average	average	JJ
cord-000248-zueoyesj	866	31	expected	expect	VBN
cord-000248-zueoyesj	866	32	surprisal	surprisal	NN
cord-000248-zueoyesj	866	33	of	of	IN
cord-000248-zueoyesj	866	34	the	the	DT
cord-000248-zueoyesj	866	35	transcriptome	transcriptome	NN
cord-000248-zueoyesj	866	36	,	,	,
cord-000248-zueoyesj	866	37	which	which	WDT
cord-000248-zueoyesj	866	38	in	in	IN
cord-000248-zueoyesj	866	39	turn	turn	NN
cord-000248-zueoyesj	866	40	has	have	VBZ
cord-000248-zueoyesj	866	41	lead	lead	VB
cord-000248-zueoyesj	866	42	us	-PRON-	PRP
cord-000248-zueoyesj	866	43	to	to	TO
cord-000248-zueoyesj	866	44	consider	consider	VB
cord-000248-zueoyesj	866	45	the	the	DT
cord-000248-zueoyesj	866	46	dysfunction	dysfunction	NN
cord-000248-zueoyesj	866	47	of	of	IN
cord-000248-zueoyesj	866	48	the	the	DT
cord-000248-zueoyesj	866	49	smallest	small	JJS
cord-000248-zueoyesj	866	50	nuclear	nuclear	JJ
cord-000248-zueoyesj	866	51	body	body	NN
cord-000248-zueoyesj	866	52	as	as	IN
cord-000248-zueoyesj	866	53	a	a	DT
cord-000248-zueoyesj	866	54	putative	putative	JJ
cord-000248-zueoyesj	866	55	biomarker	biomarker	NN
cord-000248-zueoyesj	866	56	of	of	IN
cord-000248-zueoyesj	866	57	disease	disease	NN
cord-000248-zueoyesj	866	58	progression	progression	NN
cord-000248-zueoyesj	866	59	.	.	.
cord-000248-zueoyesj	867	1	The	the	DT
cord-000248-zueoyesj	867	2	role	role	NN
cord-000248-zueoyesj	867	3	of	of	IN
cord-000248-zueoyesj	867	4	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	867	5	/	/	SYM
cord-000248-zueoyesj	867	6	PSF	PSF	NNP
cord-000248-zueoyesj	867	7	in	in	IN
cord-000248-zueoyesj	867	8	the	the	DT
cord-000248-zueoyesj	867	9	control	control	NN
cord-000248-zueoyesj	867	10	of	of	IN
cord-000248-zueoyesj	867	11	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	867	12	is	be	VBZ
cord-000248-zueoyesj	867	13	under	under	IN
cord-000248-zueoyesj	867	14	investigation	investigation	NN
cord-000248-zueoyesj	867	15	[	[	-LRB-
cord-000248-zueoyesj	867	16	787	787	CD
cord-000248-zueoyesj	867	17	]	]	-RRB-
cord-000248-zueoyesj	867	18	and	and	CC
cord-000248-zueoyesj	867	19	the	the	DT
cord-000248-zueoyesj	867	20	information	information	NN
cord-000248-zueoyesj	867	21	coming	come	VBG
cord-000248-zueoyesj	867	22	from	from	IN
cord-000248-zueoyesj	867	23	these	these	DT
cord-000248-zueoyesj	867	24	studies	study	NNS
cord-000248-zueoyesj	867	25	would	would	MD
cord-000248-zueoyesj	867	26	need	need	VB
cord-000248-zueoyesj	867	27	to	to	TO
cord-000248-zueoyesj	867	28	be	be	VB
cord-000248-zueoyesj	867	29	integrated	integrate	VBN
cord-000248-zueoyesj	867	30	with	with	IN
cord-000248-zueoyesj	867	31	their	-PRON-	PRP$
cord-000248-zueoyesj	867	32	role	role	NN
cord-000248-zueoyesj	867	33	,	,	,
cord-000248-zueoyesj	867	34	together	together	RB
cord-000248-zueoyesj	867	35	with	with	IN
cord-000248-zueoyesj	867	36	P54NRB	P54NRB	NNP
cord-000248-zueoyesj	867	37	/	/	SYM
cord-000248-zueoyesj	867	38	NONO	NONO	NNP
cord-000248-zueoyesj	867	39	and	and	CC
cord-000248-zueoyesj	867	40	TncRNA	TncRNA	NNP
cord-000248-zueoyesj	867	41	,	,	,
cord-000248-zueoyesj	867	42	in	in	IN
cord-000248-zueoyesj	867	43	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	867	44	if	if	IN
cord-000248-zueoyesj	867	45	we	-PRON-	PRP
cord-000248-zueoyesj	867	46	want	want	VBP
cord-000248-zueoyesj	867	47	to	to	TO
cord-000248-zueoyesj	867	48	achieve	achieve	VB
cord-000248-zueoyesj	867	49	a	a	DT
cord-000248-zueoyesj	867	50	better	well	JJR
cord-000248-zueoyesj	867	51	understanding	understanding	NN
cord-000248-zueoyesj	867	52	of	of	IN
cord-000248-zueoyesj	867	53	these	these	DT
cord-000248-zueoyesj	867	54	mechanisms	mechanism	NNS
cord-000248-zueoyesj	867	55	.	.	.
cord-000248-zueoyesj	868	1	In	in	IN
cord-000248-zueoyesj	868	2	this	this	DT
cord-000248-zueoyesj	868	3	contribution	contribution	NN
cord-000248-zueoyesj	868	4	we	-PRON-	PRP
cord-000248-zueoyesj	868	5	have	have	VBP
cord-000248-zueoyesj	868	6	shown	show	VBN
cord-000248-zueoyesj	868	7	that	that	IN
cord-000248-zueoyesj	868	8	for	for	IN
cord-000248-zueoyesj	868	9	the	the	DT
cord-000248-zueoyesj	868	10	melanoma	melanoma	NN
cord-000248-zueoyesj	868	11	and	and	CC
cord-000248-zueoyesj	868	12	prostate	prostate	NN
cord-000248-zueoyesj	868	13	cancer	cancer	NN
cord-000248-zueoyesj	868	14	datasets	dataset	NNS
cord-000248-zueoyesj	868	15	studied	study	VBN
cord-000248-zueoyesj	868	16	,	,	,
cord-000248-zueoyesj	868	17	the	the	DT
cord-000248-zueoyesj	868	18	quantitative	quantitative	JJ
cord-000248-zueoyesj	868	19	changes	change	NNS
cord-000248-zueoyesj	868	20	of	of	IN
cord-000248-zueoyesj	868	21	Information	Information	NNP
cord-000248-zueoyesj	868	22	Theory	Theory	NNP
cord-000248-zueoyesj	868	23	measures	measure	NNS
cord-000248-zueoyesj	868	24	,	,	,
cord-000248-zueoyesj	868	25	Normalized	Normalized	NNP
cord-000248-zueoyesj	868	26	Shannon	Shannon	NNP
cord-000248-zueoyesj	868	27	Entropy	Entropy	NNP
cord-000248-zueoyesj	868	28	,	,	,
cord-000248-zueoyesj	868	29	Jensen-	Jensen-	NNP
cord-000248-zueoyesj	868	30	Figure	Figure	NNP
cord-000248-zueoyesj	868	31	19	19	CD
cord-000248-zueoyesj	868	32	.	.	.
cord-000248-zueoyesj	869	1	The	the	DT
cord-000248-zueoyesj	869	2	stacked	stacked	JJ
cord-000248-zueoyesj	869	3	average	average	JJ
cord-000248-zueoyesj	869	4	gene	gene	NN
cord-000248-zueoyesj	869	5	expression	expression	NN
cord-000248-zueoyesj	869	6	of	of	IN
cord-000248-zueoyesj	869	7	probes	probe	NNS
cord-000248-zueoyesj	869	8	corresponding	correspond	VBG
cord-000248-zueoyesj	869	9	to	to	IN
cord-000248-zueoyesj	869	10	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	869	11	and	and	CC
cord-000248-zueoyesj	869	12	TERF2	terf2	NN
cord-000248-zueoyesj	870	1	(	(	-LRB-
cord-000248-zueoyesj	870	2	telomeric	telomeric	NNP
cord-000248-zueoyesj	870	3	repeat	repeat	NN
cord-000248-zueoyesj	870	4	binding	bind	VBG
cord-000248-zueoyesj	870	5	factor	factor	NN
cord-000248-zueoyesj	870	6	2	2	CD
cord-000248-zueoyesj	870	7	)	)	-RRB-
cord-000248-zueoyesj	870	8	in	in	IN
cord-000248-zueoyesj	870	9	True	True	NNP
cord-000248-zueoyesj	870	10	et	et	NNP
cord-000248-zueoyesj	870	11	al	al	NNP
cord-000248-zueoyesj	870	12	's	's	POS
cord-000248-zueoyesj	870	13	prostate	prostate	NN
cord-000248-zueoyesj	870	14	cancer	cancer	NN
cord-000248-zueoyesj	870	15	dataset	dataset	NN
cord-000248-zueoyesj	870	16	.	.	.
cord-000248-zueoyesj	871	1	The	the	DT
cord-000248-zueoyesj	871	2	first	first	JJ
cord-000248-zueoyesj	871	3	group	group	NN
cord-000248-zueoyesj	871	4	of	of	IN
cord-000248-zueoyesj	871	5	samples	sample	NNS
cord-000248-zueoyesj	871	6	(	(	-LRB-
cord-000248-zueoyesj	871	7	1	1	CD
cord-000248-zueoyesj	871	8	to	to	IN
cord-000248-zueoyesj	871	9	9	9	CD
cord-000248-zueoyesj	871	10	in	in	IN
cord-000248-zueoyesj	871	11	green	green	JJ
cord-000248-zueoyesj	871	12	)	)	-RRB-
cord-000248-zueoyesj	871	13	correspond	correspond	VB
cord-000248-zueoyesj	871	14	to	to	IN
cord-000248-zueoyesj	871	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	871	16	3	3	CD
cord-000248-zueoyesj	871	17	pattern	pattern	NN
cord-000248-zueoyesj	871	18	,	,	,
cord-000248-zueoyesj	871	19	indicating	indicate	VBG
cord-000248-zueoyesj	871	20	that	that	IN
cord-000248-zueoyesj	871	21	most	most	JJS
cord-000248-zueoyesj	871	22	of	of	IN
cord-000248-zueoyesj	871	23	the	the	DT
cord-000248-zueoyesj	871	24	samples	sample	NNS
cord-000248-zueoyesj	871	25	in	in	IN
cord-000248-zueoyesj	871	26	this	this	DT
cord-000248-zueoyesj	871	27	group	group	NN
cord-000248-zueoyesj	871	28	have	have	VBP
cord-000248-zueoyesj	871	29	no	no	DT
cord-000248-zueoyesj	871	30	significantly	significantly	RB
cord-000248-zueoyesj	871	31	reduced	reduce	VBN
cord-000248-zueoyesj	871	32	expression	expression	NN
cord-000248-zueoyesj	871	33	of	of	IN
cord-000248-zueoyesj	871	34	this	this	DT
cord-000248-zueoyesj	871	35	pair	pair	NN
cord-000248-zueoyesj	871	36	of	of	IN
cord-000248-zueoyesj	871	37	genes	gene	NNS
cord-000248-zueoyesj	871	38	.	.	.
cord-000248-zueoyesj	872	1	The	the	DT
cord-000248-zueoyesj	872	2	second	second	JJ
cord-000248-zueoyesj	872	3	group	group	NN
cord-000248-zueoyesj	872	4	of	of	IN
cord-000248-zueoyesj	872	5	columns	column	NNS
cord-000248-zueoyesj	872	6	(	(	-LRB-
cord-000248-zueoyesj	872	7	10	10	CD
cord-000248-zueoyesj	872	8	to	to	TO
cord-000248-zueoyesj	872	9	21	21	CD
cord-000248-zueoyesj	872	10	in	in	IN
cord-000248-zueoyesj	872	11	yellow	yellow	JJ
cord-000248-zueoyesj	872	12	)	)	-RRB-
cord-000248-zueoyesj	872	13	correspond	correspond	VBP
cord-000248-zueoyesj	872	14	to	to	IN
cord-000248-zueoyesj	872	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	872	16	4	4	CD
cord-000248-zueoyesj	872	17	patterns	pattern	NNS
cord-000248-zueoyesj	872	18	and	and	CC
cord-000248-zueoyesj	872	19	the	the	DT
cord-000248-zueoyesj	872	20	last	last	JJ
cord-000248-zueoyesj	872	21	8	8	CD
cord-000248-zueoyesj	872	22	columns	column	NNS
cord-000248-zueoyesj	872	23	(	(	-LRB-
cord-000248-zueoyesj	872	24	22	22	CD
cord-000248-zueoyesj	872	25	to	to	TO
cord-000248-zueoyesj	872	26	29	29	CD
cord-000248-zueoyesj	872	27	in	in	IN
cord-000248-zueoyesj	872	28	red	red	JJ
cord-000248-zueoyesj	872	29	)	)	-RRB-
cord-000248-zueoyesj	872	30	correspond	correspond	VB
cord-000248-zueoyesj	872	31	to	to	IN
cord-000248-zueoyesj	872	32	Gleason	Gleason	NNP
cord-000248-zueoyesj	872	33	5	5	CD
cord-000248-zueoyesj	872	34	samples	sample	NNS
cord-000248-zueoyesj	872	35	.	.	.
cord-000248-zueoyesj	873	1	A	a	DT
cord-000248-zueoyesj	873	2	very	very	RB
cord-000248-zueoyesj	873	3	recent	recent	JJ
cord-000248-zueoyesj	873	4	study	study	NN
cord-000248-zueoyesj	873	5	by	by	IN
cord-000248-zueoyesj	873	6	Ballal	Ballal	NNP
cord-000248-zueoyesj	873	7	et	et	NNP
cord-000248-zueoyesj	873	8	al	al	NNP
cord-000248-zueoyesj	873	9	.	.	NNP
cord-000248-zueoyesj	873	10	have	have	VBP
cord-000248-zueoyesj	873	11	linked	link	VBN
cord-000248-zueoyesj	873	12	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	873	13	,	,	,
cord-000248-zueoyesj	873	14	to	to	TO
cord-000248-zueoyesj	873	15	telomere	telomere	VB
cord-000248-zueoyesj	873	16	length	length	NN
cord-000248-zueoyesj	873	17	and	and	CC
cord-000248-zueoyesj	873	18	maintenance	maintenance	NN
cord-000248-zueoyesj	873	19	and	and	CC
cord-000248-zueoyesj	873	20	its	-PRON-	PRP$
cord-000248-zueoyesj	873	21	loss	loss	NN
cord-000248-zueoyesj	873	22	from	from	IN
cord-000248-zueoyesj	873	23	the	the	DT
cord-000248-zueoyesj	873	24	telomere	telomere	NN
cord-000248-zueoyesj	873	25	in	in	IN
cord-000248-zueoyesj	873	26	response	response	NN
cord-000248-zueoyesj	873	27	to	to	IN
cord-000248-zueoyesj	873	28	DNA	dna	NN
cord-000248-zueoyesj	873	29	damage	damage	NN
cord-000248-zueoyesj	873	30	[	[	-LRB-
cord-000248-zueoyesj	873	31	720	720	CD
cord-000248-zueoyesj	873	32	]	]	-RRB-
cord-000248-zueoyesj	874	1	(	(	-LRB-
cord-000248-zueoyesj	874	2	see	see	VB
cord-000248-zueoyesj	874	3	also	also	RB
cord-000248-zueoyesj	874	4	[	[	-LRB-
cord-000248-zueoyesj	874	5	721	721	CD
cord-000248-zueoyesj	874	6	]	]	-RRB-
cord-000248-zueoyesj	874	7	)	)	-RRB-
cord-000248-zueoyesj	874	8	.	.	.
cord-000248-zueoyesj	875	1	There	there	EX
cord-000248-zueoyesj	875	2	is	be	VBZ
cord-000248-zueoyesj	875	3	an	an	DT
cord-000248-zueoyesj	875	4	increasing	increase	VBG
cord-000248-zueoyesj	875	5	trend	trend	NN
cord-000248-zueoyesj	875	6	of	of	IN
cord-000248-zueoyesj	875	7	dowregulation	dowregulation	NN
cord-000248-zueoyesj	875	8	,	,	,
cord-000248-zueoyesj	875	9	so	so	IN
cord-000248-zueoyesj	875	10	it	-PRON-	PRP
cord-000248-zueoyesj	875	11	would	would	MD
cord-000248-zueoyesj	875	12	be	be	VB
cord-000248-zueoyesj	875	13	interesting	interesting	JJ
cord-000248-zueoyesj	875	14	to	to	TO
cord-000248-zueoyesj	875	15	evaluate	evaluate	VB
cord-000248-zueoyesj	875	16	if	if	IN
cord-000248-zueoyesj	875	17	indeed	indeed	RB
cord-000248-zueoyesj	875	18	this	this	DT
cord-000248-zueoyesj	875	19	pair	pair	NN
cord-000248-zueoyesj	875	20	of	of	IN
cord-000248-zueoyesj	875	21	proteins	protein	NNS
cord-000248-zueoyesj	875	22	could	could	MD
cord-000248-zueoyesj	875	23	be	be	VB
cord-000248-zueoyesj	875	24	an	an	DT
cord-000248-zueoyesj	875	25	early	early	JJ
cord-000248-zueoyesj	875	26	marker	marker	NN
cord-000248-zueoyesj	875	27	of	of	IN
cord-000248-zueoyesj	875	28	dowregulation	dowregulation	NN
cord-000248-zueoyesj	875	29	useful	useful	JJ
cord-000248-zueoyesj	875	30	to	to	TO
cord-000248-zueoyesj	875	31	evaluate	evaluate	VB
cord-000248-zueoyesj	875	32	samples	sample	NNS
cord-000248-zueoyesj	875	33	with	with	IN
cord-000248-zueoyesj	875	34	Gleason	Gleason	NNP
cord-000248-zueoyesj	875	35	pattern	pattern	NN
cord-000248-zueoyesj	875	36	2	2	CD
cord-000248-zueoyesj	875	37	,	,	,
cord-000248-zueoyesj	875	38	or	or	CC
cord-000248-zueoyesj	875	39	if	if	IN
cord-000248-zueoyesj	875	40	may	may	MD
cord-000248-zueoyesj	875	41	constitute	constitute	VB
cord-000248-zueoyesj	875	42	a	a	DT
cord-000248-zueoyesj	875	43	biomarker	biomarker	NN
cord-000248-zueoyesj	875	44	useful	useful	JJ
cord-000248-zueoyesj	875	45	to	to	TO
cord-000248-zueoyesj	875	46	distinguish	distinguish	VB
cord-000248-zueoyesj	875	47	a	a	DT
cord-000248-zueoyesj	875	48	prostate	prostate	NN
cord-000248-zueoyesj	875	49	cancer	cancer	NN
cord-000248-zueoyesj	875	50	subtype	subtype	NN
cord-000248-zueoyesj	875	51	.	.	.
cord-000248-zueoyesj	876	1	doi:10.1371/	doi:10.1371/	NNP
cord-000248-zueoyesj	877	1	journal.pone.0012262.g019	journal.pone.0012262.g019	NNP
cord-000248-zueoyesj	877	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	877	3	divergence	divergence	NN
cord-000248-zueoyesj	877	4	and	and	CC
cord-000248-zueoyesj	877	5	the	the	DT
cord-000248-zueoyesj	877	6	novel	novel	JJ
cord-000248-zueoyesj	877	7	Statistical	Statistical	NNP
cord-000248-zueoyesj	877	8	Complexity	Complexity	NNP
cord-000248-zueoyesj	877	9	quantifiers	quantifier	NNS
cord-000248-zueoyesj	877	10	defined	define	VBN
cord-000248-zueoyesj	877	11	here	here	RB
cord-000248-zueoyesj	877	12	are	be	VBP
cord-000248-zueoyesj	877	13	in	in	IN
cord-000248-zueoyesj	877	14	high	high	JJ
cord-000248-zueoyesj	877	15	correlation	correlation	NN
cord-000248-zueoyesj	877	16	with	with	IN
cord-000248-zueoyesj	877	17	gene	gene	NN
cord-000248-zueoyesj	877	18	expression	expression	NN
cord-000248-zueoyesj	877	19	changes	change	NNS
cord-000248-zueoyesj	877	20	of	of	IN
cord-000248-zueoyesj	877	21	well	well	RB
cord-000248-zueoyesj	877	22	-	-	HYPH
cord-000248-zueoyesj	877	23	established	establish	VBN
cord-000248-zueoyesj	877	24	biomarkers	biomarker	NNS
cord-000248-zueoyesj	877	25	associated	associate	VBN
cord-000248-zueoyesj	877	26	to	to	IN
cord-000248-zueoyesj	877	27	cancer	cancer	NN
cord-000248-zueoyesj	877	28	progression	progression	NN
cord-000248-zueoyesj	877	29	.	.	.
cord-000248-zueoyesj	878	1	In	in	IN
cord-000248-zueoyesj	878	2	addition	addition	NN
cord-000248-zueoyesj	878	3	,	,	,
cord-000248-zueoyesj	878	4	variations	variation	NNS
cord-000248-zueoyesj	878	5	of	of	IN
cord-000248-zueoyesj	878	6	the	the	DT
cord-000248-zueoyesj	878	7	basic	basic	JJ
cord-000248-zueoyesj	878	8	technique	technique	NN
cord-000248-zueoyesj	878	9	(	(	-LRB-
cord-000248-zueoyesj	878	10	i.e.	i.e.	FW
cord-000248-zueoyesj	878	11	a	a	DT
cord-000248-zueoyesj	878	12	modified	modify	VBN
cord-000248-zueoyesj	878	13	form	form	NN
cord-000248-zueoyesj	878	14	of	of	IN
cord-000248-zueoyesj	878	15	statistical	statistical	JJ
cord-000248-zueoyesj	878	16	complexity	complexity	NN
cord-000248-zueoyesj	878	17	)	)	-RRB-
cord-000248-zueoyesj	878	18	which	which	WDT
cord-000248-zueoyesj	878	19	allows	allow	VBZ
cord-000248-zueoyesj	878	20	us	-PRON-	PRP
cord-000248-zueoyesj	878	21	to	to	TO
cord-000248-zueoyesj	878	22	better	better	RB
cord-000248-zueoyesj	878	23	understand	understand	VB
cord-000248-zueoyesj	878	24	the	the	DT
cord-000248-zueoyesj	878	25	phenotypic	phenotypic	JJ
cord-000248-zueoyesj	878	26	changes	change	NNS
cord-000248-zueoyesj	878	27	observed	observe	VBN
cord-000248-zueoyesj	878	28	in	in	IN
cord-000248-zueoyesj	878	29	these	these	DT
cord-000248-zueoyesj	878	30	samples	sample	NNS
cord-000248-zueoyesj	878	31	which	which	WDT
cord-000248-zueoyesj	878	32	are	be	VBP
cord-000248-zueoyesj	878	33	associated	associate	VBN
cord-000248-zueoyesj	878	34	with	with	IN
cord-000248-zueoyesj	878	35	the	the	DT
cord-000248-zueoyesj	878	36	progression	progression	NN
cord-000248-zueoyesj	878	37	and	and	CC
cord-000248-zueoyesj	878	38	the	the	DT
cord-000248-zueoyesj	878	39	transitions	transition	NNS
cord-000248-zueoyesj	878	40	of	of	IN
cord-000248-zueoyesj	878	41	the	the	DT
cord-000248-zueoyesj	878	42	gene	gene	NN
cord-000248-zueoyesj	878	43	expression	expression	NN
cord-000248-zueoyesj	878	44	profiles	profile	NNS
cord-000248-zueoyesj	878	45	.	.	.
cord-000248-zueoyesj	879	1	For	for	IN
cord-000248-zueoyesj	879	2	instance	instance	NN
cord-000248-zueoyesj	879	3	,	,	,
cord-000248-zueoyesj	879	4	in	in	IN
cord-000248-zueoyesj	879	5	a	a	DT
cord-000248-zueoyesj	879	6	properly	properly	RB
cord-000248-zueoyesj	879	7	defined	define	VBN
cord-000248-zueoyesj	879	8	Statistical	Statistical	NNP
cord-000248-zueoyesj	879	9	Complexity	Complexity	NNP
cord-000248-zueoyesj	879	10	vs.	vs.	IN
cord-000248-zueoyesj	879	11	Entropy	Entropy	NNP
cord-000248-zueoyesj	879	12	plane	plane	NN
cord-000248-zueoyesj	879	13	,	,	,
cord-000248-zueoyesj	879	14	on	on	IN
cord-000248-zueoyesj	879	15	a	a	DT
cord-000248-zueoyesj	879	16	melanoma	melanoma	NN
cord-000248-zueoyesj	879	17	dataset	dataset	NN
cord-000248-zueoyesj	879	18	first	first	RB
cord-000248-zueoyesj	879	19	studied	study	VBD
cord-000248-zueoyesj	879	20	in	in	IN
cord-000248-zueoyesj	879	21	Ref	Ref	NNP
cord-000248-zueoyesj	879	22	.	.	.
cord-000248-zueoyesj	880	1	[	[	-LRB-
cord-000248-zueoyesj	880	2	110	110	CD
cord-000248-zueoyesj	880	3	]	]	-RRB-
cord-000248-zueoyesj	880	4	,	,	,
cord-000248-zueoyesj	880	5	samples	sample	NNS
cord-000248-zueoyesj	880	6	appear	appear	VBP
cord-000248-zueoyesj	880	7	in	in	IN
cord-000248-zueoyesj	880	8	well	well	RB
cord-000248-zueoyesj	880	9	differentiated	differentiated	JJ
cord-000248-zueoyesj	880	10	'	'	''
cord-000248-zueoyesj	880	11	'	'	``
cord-000248-zueoyesj	880	12	clusters	cluster	NNS
cord-000248-zueoyesj	880	13	'	'	''
cord-000248-zueoyesj	880	14	'	'	''
cord-000248-zueoyesj	880	15	.	.	.
cord-000248-zueoyesj	881	1	These	these	DT
cord-000248-zueoyesj	881	2	clusters	cluster	NNS
cord-000248-zueoyesj	881	3	correlate	correlate	VBP
cord-000248-zueoyesj	881	4	well	well	RB
cord-000248-zueoyesj	881	5	with	with	IN
cord-000248-zueoyesj	881	6	the	the	DT
cord-000248-zueoyesj	881	7	phonotypic	phonotypic	JJ
cord-000248-zueoyesj	881	8	characteristics	characteristic	NNS
cord-000248-zueoyesj	881	9	of	of	IN
cord-000248-zueoyesj	881	10	normal	normal	JJ
cord-000248-zueoyesj	881	11	skin	skin	NN
cord-000248-zueoyesj	881	12	,	,	,
cord-000248-zueoyesj	881	13	nevi	nevus	NNS
cord-000248-zueoyesj	881	14	,	,	,
cord-000248-zueoyesj	881	15	primary	primary	JJ
cord-000248-zueoyesj	881	16	and	and	CC
cord-000248-zueoyesj	881	17	metastatic	metastatic	JJ
cord-000248-zueoyesj	881	18	melanoma	melanoma	NN
cord-000248-zueoyesj	881	19	.	.	.
cord-000248-zueoyesj	882	1	In	in	IN
cord-000248-zueoyesj	882	2	this	this	DT
cord-000248-zueoyesj	882	3	'	'	''
cord-000248-zueoyesj	882	4	'	'	''
cord-000248-zueoyesj	882	5	Complexity	complexity	NN
cord-000248-zueoyesj	882	6	vs.	vs.	IN
cord-000248-zueoyesj	882	7	Entropy	Entropy	NNP
cord-000248-zueoyesj	882	8	'	'	''
cord-000248-zueoyesj	882	9	'	'	''
cord-000248-zueoyesj	882	10	plane	plane	NN
cord-000248-zueoyesj	882	11	,	,	,
cord-000248-zueoyesj	882	12	primary	primary	JJ
cord-000248-zueoyesj	882	13	melanomas	melanoma	NNS
cord-000248-zueoyesj	882	14	samples	sample	NNS
cord-000248-zueoyesj	882	15	appear	appear	VBP
cord-000248-zueoyesj	882	16	'	'	''
cord-000248-zueoyesj	882	17	'	'	``
cord-000248-zueoyesj	882	18	bridging	bridge	VBG
cord-000248-zueoyesj	882	19	'	'	''
cord-000248-zueoyesj	882	20	'	'	``
cord-000248-zueoyesj	882	21	benign	benign	JJ
cord-000248-zueoyesj	882	22	nevi	nevus	NNS
cord-000248-zueoyesj	882	23	and	and	CC
cord-000248-zueoyesj	882	24	metastatic	metastatic	JJ
cord-000248-zueoyesj	882	25	melanoma	melanoma	NN
cord-000248-zueoyesj	882	26	samples	sample	NNS
cord-000248-zueoyesj	882	27	.	.	.
cord-000248-zueoyesj	883	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	883	2	results	result	NNS
cord-000248-zueoyesj	883	3	may	may	MD
cord-000248-zueoyesj	883	4	also	also	RB
cord-000248-zueoyesj	883	5	suggest	suggest	VB
cord-000248-zueoyesj	883	6	that	that	IN
cord-000248-zueoyesj	883	7	the	the	DT
cord-000248-zueoyesj	883	8	evolution	evolution	NN
cord-000248-zueoyesj	883	9	of	of	IN
cord-000248-zueoyesj	883	10	metastatic	metastatic	JJ
cord-000248-zueoyesj	883	11	melanoma	melanoma	NN
cord-000248-zueoyesj	883	12	leads	lead	VBZ
cord-000248-zueoyesj	883	13	to	to	IN
cord-000248-zueoyesj	883	14	at	at	RB
cord-000248-zueoyesj	883	15	least	least	RBS
cord-000248-zueoyesj	883	16	two	two	CD
cord-000248-zueoyesj	883	17	different	different	JJ
cord-000248-zueoyesj	883	18	subtypes	subtype	NNS
cord-000248-zueoyesj	883	19	.	.	.
cord-000248-zueoyesj	884	1	The	the	DT
cord-000248-zueoyesj	884	2	Normalized	Normalized	NNP
cord-000248-zueoyesj	884	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	884	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	884	5	of	of	IN
cord-000248-zueoyesj	884	6	a	a	DT
cord-000248-zueoyesj	884	7	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	884	8	sample	sample	NN
cord-000248-zueoyesj	884	9	profile	profile	NN
cord-000248-zueoyesj	884	10	is	be	VBZ
cord-000248-zueoyesj	884	11	calculated	calculate	VBN
cord-000248-zueoyesj	884	12	associating	associate	VBG
cord-000248-zueoyesj	884	13	the	the	DT
cord-000248-zueoyesj	884	14	measured	measure	VBN
cord-000248-zueoyesj	884	15	expression	expression	NN
cord-000248-zueoyesj	884	16	values	value	NNS
cord-000248-zueoyesj	884	17	of	of	IN
cord-000248-zueoyesj	884	18	a	a	DT
cord-000248-zueoyesj	884	19	gene	gene	NN
cord-000248-zueoyesj	884	20	with	with	IN
cord-000248-zueoyesj	884	21	the	the	DT
cord-000248-zueoyesj	884	22	relatively	relatively	JJ
cord-000248-zueoyesj	884	23	probability	probability	NN
cord-000248-zueoyesj	884	24	of	of	IN
cord-000248-zueoyesj	884	25	being	be	VBG
cord-000248-zueoyesj	884	26	expressed	express	VBN
cord-000248-zueoyesj	884	27	.	.	.
cord-000248-zueoyesj	885	1	We	-PRON-	PRP
cord-000248-zueoyesj	885	2	have	have	VBP
cord-000248-zueoyesj	885	3	observed	observe	VBN
cord-000248-zueoyesj	885	4	that	that	IN
cord-000248-zueoyesj	885	5	,	,	,
cord-000248-zueoyesj	885	6	in	in	IN
cord-000248-zueoyesj	885	7	general	general	JJ
cord-000248-zueoyesj	885	8	,	,	,
cord-000248-zueoyesj	885	9	the	the	DT
cord-000248-zueoyesj	885	10	transcriptomes	transcriptome	NNS
cord-000248-zueoyesj	885	11	of	of	IN
cord-000248-zueoyesj	885	12	tumour	tumour	NN
cord-000248-zueoyesj	885	13	progressing	progress	VBG
cord-000248-zueoyesj	885	14	cells	cell	NNS
cord-000248-zueoyesj	885	15	tend	tend	VBP
cord-000248-zueoyesj	885	16	to	to	TO
cord-000248-zueoyesj	885	17	have	have	VB
cord-000248-zueoyesj	885	18	lower	low	JJR
cord-000248-zueoyesj	885	19	values	value	NNS
cord-000248-zueoyesj	885	20	of	of	IN
cord-000248-zueoyesj	885	21	Normalized	Normalized	NNP
cord-000248-zueoyesj	885	22	Shannon	Shannon	NNP
cord-000248-zueoyesj	885	23	Entropy	Entropy	NNP
cord-000248-zueoyesj	885	24	than	than	IN
cord-000248-zueoyesj	885	25	normal	normal	JJ
cord-000248-zueoyesj	885	26	ones	one	NNS
cord-000248-zueoyesj	885	27	.	.	.
cord-000248-zueoyesj	886	1	Given	give	VBN
cord-000248-zueoyesj	886	2	a	a	DT
cord-000248-zueoyesj	886	3	population	population	NN
cord-000248-zueoyesj	886	4	of	of	IN
cord-000248-zueoyesj	886	5	normal	normal	JJ
cord-000248-zueoyesj	886	6	cells	cell	NNS
cord-000248-zueoyesj	886	7	of	of	IN
cord-000248-zueoyesj	886	8	a	a	DT
cord-000248-zueoyesj	886	9	given	give	VBN
cord-000248-zueoyesj	886	10	tissue	tissue	NN
cord-000248-zueoyesj	886	11	type	type	NN
cord-000248-zueoyesj	886	12	it	-PRON-	PRP
cord-000248-zueoyesj	886	13	is	be	VBZ
cord-000248-zueoyesj	886	14	then	then	RB
cord-000248-zueoyesj	886	15	possible	possible	JJ
cord-000248-zueoyesj	886	16	to	to	TO
cord-000248-zueoyesj	886	17	compute	compute	VB
cord-000248-zueoyesj	886	18	useful	useful	JJ
cord-000248-zueoyesj	886	19	measure	measure	NN
cord-000248-zueoyesj	886	20	of	of	IN
cord-000248-zueoyesj	886	21	divergence	divergence	NN
cord-000248-zueoyesj	886	22	of	of	IN
cord-000248-zueoyesj	886	23	cancer	cancer	NN
cord-000248-zueoyesj	886	24	cell	cell	NN
cord-000248-zueoyesj	886	25	profiles	profile	NNS
cord-000248-zueoyesj	886	26	from	from	IN
cord-000248-zueoyesj	886	27	the	the	DT
cord-000248-zueoyesj	886	28	normal	normal	JJ
cord-000248-zueoyesj	886	29	expression	expression	NN
cord-000248-zueoyesj	886	30	average	average	JJ
cord-000248-zueoyesj	886	31	profile	profile	NN
cord-000248-zueoyesj	886	32	,	,	,
cord-000248-zueoyesj	886	33	in	in	IN
cord-000248-zueoyesj	886	34	terms	term	NNS
cord-000248-zueoyesj	886	35	of	of	IN
cord-000248-zueoyesj	886	36	Information	information	NN
cord-000248-zueoyesj	886	37	Theory	Theory	NNP
cord-000248-zueoyesj	886	38	quantifiers	quantifier	NNS
cord-000248-zueoyesj	886	39	,	,	,
cord-000248-zueoyesj	887	1	the	the	DT
cord-000248-zueoyesj	887	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	887	3	Eveness	Eveness	NNP
cord-000248-zueoyesj	887	4	normalized	normalize	VBD
cord-000248-zueoyesj	887	5	entropy	entropy	NN
cord-000248-zueoyesj	887	6	and	and	CC
cord-000248-zueoyesj	887	7	generalized	generalized	JJ
cord-000248-zueoyesj	887	8	statistical	statistical	JJ
cord-000248-zueoyesj	887	9	complexity	complexity	NN
cord-000248-zueoyesj	887	10	[	[	-LRB-
cord-000248-zueoyesj	887	11	788	788	CD
cord-000248-zueoyesj	887	12	,	,	,
cord-000248-zueoyesj	887	13	789	789	CD
cord-000248-zueoyesj	887	14	,	,	,
cord-000248-zueoyesj	887	15	790	790	CD
cord-000248-zueoyesj	887	16	]	]	-RRB-
cord-000248-zueoyesj	887	17	.	.	.
cord-000248-zueoyesj	888	1	In	in	IN
cord-000248-zueoyesj	888	2	addition	addition	NN
cord-000248-zueoyesj	888	3	,	,	,
cord-000248-zueoyesj	888	4	our	-PRON-	PRP$
cord-000248-zueoyesj	888	5	observation	observation	NN
cord-000248-zueoyesj	888	6	of	of	IN
cord-000248-zueoyesj	888	7	the	the	DT
cord-000248-zueoyesj	888	8	correlation	correlation	NN
cord-000248-zueoyesj	888	9	of	of	IN
cord-000248-zueoyesj	888	10	the	the	DT
cord-000248-zueoyesj	888	11	statistical	statistical	JJ
cord-000248-zueoyesj	888	12	complexity	complexity	NN
cord-000248-zueoyesj	888	13	of	of	IN
cord-000248-zueoyesj	888	14	tumours	tumour	NNS
cord-000248-zueoyesj	888	15	with	with	IN
cord-000248-zueoyesj	888	16	its	-PRON-	PRP$
cord-000248-zueoyesj	888	17	natural	natural	JJ
cord-000248-zueoyesj	888	18	progression	progression	NN
cord-000248-zueoyesj	888	19	allows	allow	VBZ
cord-000248-zueoyesj	888	20	an	an	DT
cord-000248-zueoyesj	888	21	unprecedented	unprecedented	JJ
cord-000248-zueoyesj	888	22	way	way	NN
cord-000248-zueoyesj	888	23	of	of	IN
cord-000248-zueoyesj	888	24	finding	find	VBG
cord-000248-zueoyesj	888	25	biomarkers	biomarker	NNS
cord-000248-zueoyesj	888	26	that	that	WDT
cord-000248-zueoyesj	888	27	links	link	VBZ
cord-000248-zueoyesj	888	28	with	with	IN
cord-000248-zueoyesj	888	29	the	the	DT
cord-000248-zueoyesj	888	30	gradual	gradual	JJ
cord-000248-zueoyesj	888	31	deterioration	deterioration	NN
cord-000248-zueoyesj	888	32	of	of	IN
cord-000248-zueoyesj	888	33	the	the	DT
cord-000248-zueoyesj	888	34	genome	genome	NN
cord-000248-zueoyesj	888	35	integrity	integrity	NN
cord-000248-zueoyesj	888	36	.	.	.
cord-000248-zueoyesj	889	1	The	the	DT
cord-000248-zueoyesj	889	2	proposed	propose	VBN
cord-000248-zueoyesj	889	3	methodology	methodology	NN
cord-000248-zueoyesj	889	4	uncovered	uncover	VBN
cord-000248-zueoyesj	889	5	,	,	,
cord-000248-zueoyesj	889	6	for	for	IN
cord-000248-zueoyesj	889	7	the	the	DT
cord-000248-zueoyesj	889	8	first	first	JJ
cord-000248-zueoyesj	889	9	time	time	NN
cord-000248-zueoyesj	889	10	,	,	,
cord-000248-zueoyesj	889	11	evidence	evidence	NN
cord-000248-zueoyesj	889	12	of	of	IN
cord-000248-zueoyesj	889	13	the	the	DT
cord-000248-zueoyesj	889	14	putative	putative	JJ
cord-000248-zueoyesj	889	15	role	role	NN
cord-000248-zueoyesj	889	16	of	of	IN
cord-000248-zueoyesj	889	17	impared	impared	JJ
cord-000248-zueoyesj	889	18	centrosome	centrosome	NN
cord-000248-zueoyesj	889	19	cohesion	cohesion	NN
cord-000248-zueoyesj	889	20	in	in	IN
cord-000248-zueoyesj	889	21	melanoma	melanoma	NN
cord-000248-zueoyesj	889	22	progression	progression	NN
cord-000248-zueoyesj	889	23	.	.	.
cord-000248-zueoyesj	890	1	Statistical	statistical	JJ
cord-000248-zueoyesj	890	2	complexity	complexity	NN
cord-000248-zueoyesj	890	3	has	have	VBZ
cord-000248-zueoyesj	890	4	then	then	RB
cord-000248-zueoyesj	890	5	been	be	VBN
cord-000248-zueoyesj	890	6	able	able	JJ
cord-000248-zueoyesj	890	7	to	to	TO
cord-000248-zueoyesj	890	8	pinpoint	pinpoint	VB
cord-000248-zueoyesj	890	9	otherwise	otherwise	RB
cord-000248-zueoyesj	890	10	unrecognized	unrecognized	JJ
cord-000248-zueoyesj	890	11	biomarkers	biomarker	NNS
cord-000248-zueoyesj	890	12	in	in	IN
cord-000248-zueoyesj	890	13	concert	concert	NN
cord-000248-zueoyesj	890	14	with	with	IN
cord-000248-zueoyesj	890	15	existing	exist	VBG
cord-000248-zueoyesj	890	16	ones	one	NNS
cord-000248-zueoyesj	890	17	,	,	,
cord-000248-zueoyesj	890	18	reinforcing	reinforce	VBG
cord-000248-zueoyesj	890	19	the	the	DT
cord-000248-zueoyesj	890	20	view	view	NN
cord-000248-zueoyesj	890	21	that	that	IN
cord-000248-zueoyesj	890	22	'	'	''
cord-000248-zueoyesj	890	23	'	'	``
cord-000248-zueoyesj	890	24	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	890	25	chaos	chaos	NN
cord-000248-zueoyesj	890	26	'	'	''
cord-000248-zueoyesj	890	27	'	'	''
cord-000248-zueoyesj	890	28	and	and	CC
cord-000248-zueoyesj	890	29	'	'	''
cord-000248-zueoyesj	890	30	'	'	''
cord-000248-zueoyesj	890	31	cancer	cancer	NN
cord-000248-zueoyesj	890	32	as	as	IN
cord-000248-zueoyesj	890	33	a	a	DT
cord-000248-zueoyesj	890	34	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	890	35	disease	disease	NN
cord-000248-zueoyesj	890	36	'	'	''
cord-000248-zueoyesj	890	37	'	'	''
cord-000248-zueoyesj	890	38	can	can	MD
cord-000248-zueoyesj	890	39	be	be	VB
cord-000248-zueoyesj	890	40	a	a	DT
cord-000248-zueoyesj	890	41	useful	useful	JJ
cord-000248-zueoyesj	890	42	guiding	guide	VBG
cord-000248-zueoyesj	890	43	principle	principle	NN
cord-000248-zueoyesj	890	44	to	to	TO
cord-000248-zueoyesj	890	45	understand	understand	VB
cord-000248-zueoyesj	890	46	the	the	DT
cord-000248-zueoyesj	890	47	molecular	molecular	JJ
cord-000248-zueoyesj	890	48	biology	biology	NN
cord-000248-zueoyesj	890	49	of	of	IN
cord-000248-zueoyesj	890	50	cancer	cancer	NN
cord-000248-zueoyesj	890	51	and	and	CC
cord-000248-zueoyesj	890	52	uncover	uncover	VB
cord-000248-zueoyesj	890	53	the	the	DT
cord-000248-zueoyesj	890	54	timeline	timeline	NN
cord-000248-zueoyesj	890	55	of	of	IN
cord-000248-zueoyesj	890	56	its	-PRON-	PRP$
cord-000248-zueoyesj	890	57	progression	progression	NN
cord-000248-zueoyesj	890	58	.	.	.
cord-000248-zueoyesj	891	1	This	this	DT
cord-000248-zueoyesj	891	2	is	be	VBZ
cord-000248-zueoyesj	891	3	a	a	DT
cord-000248-zueoyesj	891	4	powerful	powerful	JJ
cord-000248-zueoyesj	891	5	method	method	NN
cord-000248-zueoyesj	891	6	to	to	TO
cord-000248-zueoyesj	891	7	uncover	uncover	VB
cord-000248-zueoyesj	891	8	'	'	''
cord-000248-zueoyesj	891	9	'	'	``
cord-000248-zueoyesj	891	10	oncosystems	oncosystem	NNS
cord-000248-zueoyesj	891	11	'	'	''
cord-000248-zueoyesj	891	12	'	'	''
cord-000248-zueoyesj	891	13	instead	instead	RB
cord-000248-zueoyesj	891	14	of	of	IN
cord-000248-zueoyesj	891	15	'	'	``
cord-000248-zueoyesj	891	16	'	'	``
cord-000248-zueoyesj	891	17	oncogenes	oncogene	NNS
cord-000248-zueoyesj	891	18	'	'	''
cord-000248-zueoyesj	891	19	'	'	''
cord-000248-zueoyesj	891	20	.	.	.
cord-000248-zueoyesj	891	21	'	'	''
cord-000248-zueoyesj	891	22	'	'	``
cord-000248-zueoyesj	891	23	Oncosystems	Oncosystems	NNP
cord-000248-zueoyesj	891	24	'	'	POS
cord-000248-zueoyesj	891	25	'	'	''
cord-000248-zueoyesj	891	26	are	be	VBP
cord-000248-zueoyesj	891	27	a	a	DT
cord-000248-zueoyesj	891	28	highly	highly	RB
cord-000248-zueoyesj	891	29	differentially	differentially	RB
cord-000248-zueoyesj	891	30	disregulated	disregulate	VBN
cord-000248-zueoyesj	891	31	set	set	NN
cord-000248-zueoyesj	891	32	of	of	IN
cord-000248-zueoyesj	891	33	genes	gene	NNS
cord-000248-zueoyesj	891	34	that	that	WDT
cord-000248-zueoyesj	891	35	,	,	,
cord-000248-zueoyesj	891	36	if	if	IN
cord-000248-zueoyesj	891	37	linked	link	VBN
cord-000248-zueoyesj	891	38	with	with	IN
cord-000248-zueoyesj	891	39	the	the	DT
cord-000248-zueoyesj	891	40	molecular	molecular	NN
cord-000248-zueoyesj	891	41	'	'	''
cord-000248-zueoyesj	891	42	'	'	``
cord-000248-zueoyesj	891	43	hallmarks	hallmark	NNS
cord-000248-zueoyesj	891	44	of	of	IN
cord-000248-zueoyesj	891	45	cancer	cancer	NN
cord-000248-zueoyesj	891	46	'	'	''
cord-000248-zueoyesj	891	47	'	'	''
cord-000248-zueoyesj	891	48	described	describe	VBN
cord-000248-zueoyesj	891	49	in	in	IN
cord-000248-zueoyesj	891	50	the	the	DT
cord-000248-zueoyesj	891	51	introduction	introduction	NN
cord-000248-zueoyesj	891	52	,	,	,
cord-000248-zueoyesj	891	53	and	and	CC
cord-000248-zueoyesj	891	54	existing	exist	VBG
cord-000248-zueoyesj	891	55	databases	database	NNS
cord-000248-zueoyesj	891	56	with	with	IN
cord-000248-zueoyesj	891	57	putative	putative	JJ
cord-000248-zueoyesj	891	58	common	common	JJ
cord-000248-zueoyesj	891	59	functional	functional	JJ
cord-000248-zueoyesj	891	60	genomic	genomic	JJ
cord-000248-zueoyesj	891	61	annotations	annotation	NNS
cord-000248-zueoyesj	891	62	,	,	,
cord-000248-zueoyesj	891	63	can	can	MD
cord-000248-zueoyesj	891	64	help	help	VB
cord-000248-zueoyesj	891	65	to	to	TO
cord-000248-zueoyesj	891	66	understand	understand	VB
cord-000248-zueoyesj	891	67	the	the	DT
cord-000248-zueoyesj	891	68	biological	biological	JJ
cord-000248-zueoyesj	891	69	progression	progression	NN
cord-000248-zueoyesj	891	70	pathways	pathway	NNS
cord-000248-zueoyesj	891	71	that	that	WDT
cord-000248-zueoyesj	891	72	drive	drive	VBP
cord-000248-zueoyesj	891	73	the	the	DT
cord-000248-zueoyesj	891	74	disease	disease	NN
cord-000248-zueoyesj	891	75	.	.	.
cord-000248-zueoyesj	892	1	On	on	IN
cord-000248-zueoyesj	892	2	one	one	CD
cord-000248-zueoyesj	892	3	of	of	IN
cord-000248-zueoyesj	892	4	the	the	DT
cord-000248-zueoyesj	892	5	prostate	prostate	NN
cord-000248-zueoyesj	892	6	cancer	cancer	NN
cord-000248-zueoyesj	892	7	dataset	dataset	NN
cord-000248-zueoyesj	892	8	studied	study	VBD
cord-000248-zueoyesj	892	9	(	(	-LRB-
cord-000248-zueoyesj	892	10	obtained	obtain	VBN
cord-000248-zueoyesj	892	11	from	from	IN
cord-000248-zueoyesj	892	12	a	a	DT
cord-000248-zueoyesj	892	13	previous	previous	JJ
cord-000248-zueoyesj	892	14	published	publish	VBN
cord-000248-zueoyesj	892	15	study	study	NN
cord-000248-zueoyesj	892	16	,	,	,
cord-000248-zueoyesj	892	17	[	[	-LRB-
cord-000248-zueoyesj	892	18	44	44	CD
cord-000248-zueoyesj	892	19	]	]	-RRB-
cord-000248-zueoyesj	892	20	)	)	-RRB-
cord-000248-zueoyesj	892	21	,	,	,
cord-000248-zueoyesj	892	22	we	-PRON-	PRP
cord-000248-zueoyesj	892	23	observe	observe	VBP
cord-000248-zueoyesj	892	24	a	a	DT
cord-000248-zueoyesj	892	25	gradual	gradual	JJ
cord-000248-zueoyesj	892	26	pattern	pattern	NN
cord-000248-zueoyesj	892	27	of	of	IN
cord-000248-zueoyesj	892	28	reduction	reduction	NN
cord-000248-zueoyesj	892	29	of	of	IN
cord-000248-zueoyesj	892	30	Normalized	Normalized	NNP
cord-000248-zueoyesj	892	31	Shannon	Shannon	NNP
cord-000248-zueoyesj	892	32	Entropy	Entropy	NNP
cord-000248-zueoyesj	892	33	from	from	IN
cord-000248-zueoyesj	892	34	three	three	CD
cord-000248-zueoyesj	892	35	well	well	RB
cord-000248-zueoyesj	892	36	characterized	characterize	VBN
cord-000248-zueoyesj	892	37	tissue	tissue	NN
cord-000248-zueoyesj	892	38	types	type	NNS
cord-000248-zueoyesj	892	39	:	:	:
cord-000248-zueoyesj	892	40	normal	normal	JJ
cord-000248-zueoyesj	892	41	prostate	prostate	NN
cord-000248-zueoyesj	892	42	,	,	,
cord-000248-zueoyesj	892	43	primary	primary	JJ
cord-000248-zueoyesj	892	44	prostate	prostate	NN
cord-000248-zueoyesj	892	45	tumours	tumour	NNS
cord-000248-zueoyesj	892	46	and	and	CC
cord-000248-zueoyesj	892	47	lymph	lymph	NN
cord-000248-zueoyesj	892	48	node	node	NN
cord-000248-zueoyesj	892	49	metastases	metastasis	NNS
cord-000248-zueoyesj	892	50	.	.	.
cord-000248-zueoyesj	893	1	On	on	IN
cord-000248-zueoyesj	893	2	a	a	DT
cord-000248-zueoyesj	893	3	different	different	JJ
cord-000248-zueoyesj	893	4	dataset	dataset	NN
cord-000248-zueoyesj	893	5	on	on	IN
cord-000248-zueoyesj	893	6	prostate	prostate	NN
cord-000248-zueoyesj	893	7	cancer	cancer	NN
cord-000248-zueoyesj	893	8	(	(	-LRB-
cord-000248-zueoyesj	893	9	from	from	IN
cord-000248-zueoyesj	893	10	Ref	Ref	NNP
cord-000248-zueoyesj	893	11	[	[	-LRB-
cord-000248-zueoyesj	893	12	332	332	CD
cord-000248-zueoyesj	893	13	]	]	-RRB-
cord-000248-zueoyesj	893	14	)	)	-RRB-
cord-000248-zueoyesj	893	15	,	,	,
cord-000248-zueoyesj	893	16	we	-PRON-	PRP
cord-000248-zueoyesj	893	17	observe	observe	VBP
cord-000248-zueoyesj	893	18	that	that	IN
cord-000248-zueoyesj	893	19	a	a	DT
cord-000248-zueoyesj	893	20	group	group	NN
cord-000248-zueoyesj	893	21	of	of	IN
cord-000248-zueoyesj	893	22	samples	sample	NNS
cord-000248-zueoyesj	893	23	having	have	VBG
cord-000248-zueoyesj	893	24	Gleason	Gleason	NNP
cord-000248-zueoyesj	893	25	Figure	Figure	NNP
cord-000248-zueoyesj	893	26	16	16	CD
cord-000248-zueoyesj	893	27	is	be	VBZ
cord-000248-zueoyesj	893	28	that	that	IN
cord-000248-zueoyesj	893	29	we	-PRON-	PRP
cord-000248-zueoyesj	893	30	have	have	VBP
cord-000248-zueoyesj	893	31	now	now	RB
cord-000248-zueoyesj	893	32	highlighted	highlight	VBN
cord-000248-zueoyesj	893	33	the	the	DT
cord-000248-zueoyesj	893	34	position	position	NN
cord-000248-zueoyesj	893	35	of	of	IN
cord-000248-zueoyesj	893	36	s	s	NNP
cord-000248-zueoyesj	893	37	ome	ome	NN
cord-000248-zueoyesj	893	38	probes	probe	NNS
cord-000248-zueoyesj	893	39	which	which	WDT
cord-000248-zueoyesj	893	40	have	have	VBP
cord-000248-zueoyesj	893	41	been	be	VBN
cord-000248-zueoyesj	893	42	annotated	annotate	VBN
cord-000248-zueoyesj	893	43	as	as	IN
cord-000248-zueoyesj	893	44	corresponding	correspond	VBG
cord-000248-zueoyesj	893	45	to	to	IN
cord-000248-zueoyesj	893	46	'	'	''
cord-000248-zueoyesj	893	47	'	'	''
cord-000248-zueoyesj	893	48	non	non	JJ
cord-000248-zueoyesj	893	49	-	-	JJ
cord-000248-zueoyesj	893	50	coding	coding	JJ
cord-000248-zueoyesj	893	51	RNAs	rna	NNS
cord-000248-zueoyesj	893	52	'	'	''
cord-000248-zueoyesj	893	53	'	'	''
cord-000248-zueoyesj	893	54	.	.	.
cord-000248-zueoyesj	894	1	In	in	IN
cord-000248-zueoyesj	894	2	particular	particular	JJ
cord-000248-zueoyesj	894	3	,	,	,
cord-000248-zueoyesj	894	4	we	-PRON-	PRP
cord-000248-zueoyesj	894	5	highlight	highlight	VBP
cord-000248-zueoyesj	894	6	those	those	DT
cord-000248-zueoyesj	894	7	of	of	IN
cord-000248-zueoyesj	894	8	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	894	9	(	(	-LRB-
cord-000248-zueoyesj	894	10	Metastasis	metastasis	NN
cord-000248-zueoyesj	894	11	associated	associate	VBD
cord-000248-zueoyesj	894	12	lung	lung	NN
cord-000248-zueoyesj	894	13	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	894	14	transcript	transcript	NN
cord-000248-zueoyesj	894	15	1	1	CD
cord-000248-zueoyesj	894	16	,	,	,
cord-000248-zueoyesj	894	17	(	(	-LRB-
cord-000248-zueoyesj	894	18	non	non	JJ
cord-000248-zueoyesj	894	19	-	-	JJ
cord-000248-zueoyesj	894	20	protein	protein	JJ
cord-000248-zueoyesj	894	21	coding	coding	NN
cord-000248-zueoyesj	894	22	)	)	-RRB-
cord-000248-zueoyesj	894	23	)	)	-RRB-
cord-000248-zueoyesj	894	24	,	,	,
cord-000248-zueoyesj	894	25	SNORA60	SNORA60	NNP
cord-000248-zueoyesj	895	1	(	(	-LRB-
cord-000248-zueoyesj	895	2	small	small	JJ
cord-000248-zueoyesj	895	3	nucleolar	nucleolar	NNP
cord-000248-zueoyesj	895	4	RNA	RNA	NNP
cord-000248-zueoyesj	895	5	,	,	,
cord-000248-zueoyesj	895	6	H	H	NNP
cord-000248-zueoyesj	895	7	/	/	SYM
cord-000248-zueoyesj	895	8	ACA	ACA	NNP
cord-000248-zueoyesj	895	9	box	box	NN
cord-000248-zueoyesj	895	10	60	60	CD
cord-000248-zueoyesj	895	11	)	)	-RRB-
cord-000248-zueoyesj	895	12	;	;	:
cord-000248-zueoyesj	896	1	both	both	DT
cord-000248-zueoyesj	896	2	increasingly	increasingly	RB
cord-000248-zueoyesj	896	3	downregulated	downregulated	JJ
cord-000248-zueoyesj	896	4	,	,	,
cord-000248-zueoyesj	896	5	SNHG1	SNHG1	NNP
cord-000248-zueoyesj	896	6	(	(	-LRB-
cord-000248-zueoyesj	896	7	small	small	JJ
cord-000248-zueoyesj	896	8	nucleolar	nucleolar	NNP
cord-000248-zueoyesj	896	9	RNA	RNA	NNP
cord-000248-zueoyesj	896	10	host	host	NN
cord-000248-zueoyesj	896	11	gene	gene	NN
cord-000248-zueoyesj	896	12	1	1	CD
cord-000248-zueoyesj	896	13	(	(	-LRB-
cord-000248-zueoyesj	896	14	non	non	JJ
cord-000248-zueoyesj	896	15	-	-	JJ
cord-000248-zueoyesj	896	16	protein	protein	JJ
cord-000248-zueoyesj	896	17	coding	coding	NN
cord-000248-zueoyesj	896	18	)	)	-RRB-
cord-000248-zueoyesj	896	19	)	)	-RRB-
cord-000248-zueoyesj	896	20	and	and	CC
cord-000248-zueoyesj	896	21	SNHG8	snhg8	IN
cord-000248-zueoyesj	896	22	(	(	-LRB-
cord-000248-zueoyesj	896	23	small	small	JJ
cord-000248-zueoyesj	896	24	nucleolar	nucleolar	NNP
cord-000248-zueoyesj	896	25	RNA	RNA	NNP
cord-000248-zueoyesj	896	26	host	host	NN
cord-000248-zueoyesj	896	27	gene	gene	NN
cord-000248-zueoyesj	896	28	8	8	CD
cord-000248-zueoyesj	896	29	(	(	-LRB-
cord-000248-zueoyesj	896	30	non	non	JJ
cord-000248-zueoyesj	896	31	-	-	JJ
cord-000248-zueoyesj	896	32	protein	protein	JJ
cord-000248-zueoyesj	896	33	coding	coding	NN
cord-000248-zueoyesj	896	34	)	)	-RRB-
cord-000248-zueoyesj	896	35	)	)	-RRB-
cord-000248-zueoyesj	896	36	.	.	.
cord-000248-zueoyesj	897	1	The	the	DT
cord-000248-zueoyesj	897	2	probes	probe	NNS
cord-000248-zueoyesj	897	3	for	for	IN
cord-000248-zueoyesj	897	4	MALAT1	malat1	NN
cord-000248-zueoyesj	897	5	/	/	SYM
cord-000248-zueoyesj	897	6	MALAT-1	MALAT-1	NNP
cord-000248-zueoyesj	897	7	[	[	-LRB-
cord-000248-zueoyesj	897	8	742	742	CD
cord-000248-zueoyesj	897	9	,	,	,
cord-000248-zueoyesj	897	10	746	746	CD
cord-000248-zueoyesj	897	11	,	,	,
cord-000248-zueoyesj	897	12	747	747	CD
cord-000248-zueoyesj	897	13	,	,	,
cord-000248-zueoyesj	897	14	748	748	CD
cord-000248-zueoyesj	897	15	,	,	,
cord-000248-zueoyesj	897	16	749	749	CD
cord-000248-zueoyesj	897	17	,	,	,
cord-000248-zueoyesj	897	18	750	750	CD
cord-000248-zueoyesj	897	19	,	,	,
cord-000248-zueoyesj	897	20	751	751	CD
cord-000248-zueoyesj	897	21	,	,	,
cord-000248-zueoyesj	897	22	752	752	CD
cord-000248-zueoyesj	897	23	,	,	,
cord-000248-zueoyesj	897	24	753	753	CD
cord-000248-zueoyesj	897	25	,	,	,
cord-000248-zueoyesj	897	26	754	754	CD
cord-000248-zueoyesj	897	27	,	,	,
cord-000248-zueoyesj	897	28	755	755	CD
cord-000248-zueoyesj	897	29	,	,	,
cord-000248-zueoyesj	897	30	756	756	CD
cord-000248-zueoyesj	897	31	,	,	,
cord-000248-zueoyesj	897	32	757	757	CD
cord-000248-zueoyesj	897	33	,	,	,
cord-000248-zueoyesj	897	34	758	758	CD
cord-000248-zueoyesj	897	35	]	]	-RRB-
cord-000248-zueoyesj	897	36	have	have	VBP
cord-000248-zueoyesj	897	37	a	a	DT
cord-000248-zueoyesj	897	38	very	very	RB
cord-000248-zueoyesj	897	39	conspiquous	conspiquous	JJ
cord-000248-zueoyesj	897	40	position	position	NN
cord-000248-zueoyesj	897	41	,	,	,
cord-000248-zueoyesj	897	42	which	which	WDT
cord-000248-zueoyesj	897	43	we	-PRON-	PRP
cord-000248-zueoyesj	897	44	could	could	MD
cord-000248-zueoyesj	897	45	judge	judge	VB
cord-000248-zueoyesj	897	46	a	a	DT
cord-000248-zueoyesj	897	47	priori	priori	NN
cord-000248-zueoyesj	897	48	to	to	TO
cord-000248-zueoyesj	897	49	be	be	VB
cord-000248-zueoyesj	897	50	equivalent	equivalent	JJ
cord-000248-zueoyesj	897	51	in	in	IN
cord-000248-zueoyesj	897	52	relevance	relevance	NN
cord-000248-zueoyesj	897	53	to	to	IN
cord-000248-zueoyesj	897	54	those	those	DT
cord-000248-zueoyesj	897	55	of	of	IN
cord-000248-zueoyesj	897	56	the	the	DT
cord-000248-zueoyesj	897	57	previously	previously	RB
cord-000248-zueoyesj	897	58	discussed	discuss	VBN
cord-000248-zueoyesj	897	59	roles	role	NNS
cord-000248-zueoyesj	897	60	of	of	IN
cord-000248-zueoyesj	897	61	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	897	62	,	,	,
cord-000248-zueoyesj	897	63	CD40	CD40	NNP
cord-000248-zueoyesj	897	64	,	,	,
cord-000248-zueoyesj	897	65	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	897	66	,	,	,
cord-000248-zueoyesj	897	67	and	and	CC
cord-000248-zueoyesj	897	68	TP53	TP53	NNP
cord-000248-zueoyesj	897	69	(	(	-LRB-
cord-000248-zueoyesj	897	70	see	see	VB
cord-000248-zueoyesj	897	71	Figure	Figure	NNP
cord-000248-zueoyesj	897	72	16	16	CD
cord-000248-zueoyesj	897	73	)	)	-RRB-
cord-000248-zueoyesj	897	74	.	.	.
cord-000248-zueoyesj	898	1	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	898	2	has	have	VBZ
cord-000248-zueoyesj	898	3	been	be	VBN
cord-000248-zueoyesj	898	4	recently	recently	RB
cord-000248-zueoyesj	898	5	pointed	point	VBN
cord-000248-zueoyesj	898	6	as	as	IN
cord-000248-zueoyesj	898	7	a	a	DT
cord-000248-zueoyesj	898	8	biomarker	biomarker	NN
cord-000248-zueoyesj	898	9	in	in	IN
cord-000248-zueoyesj	898	10	primary	primary	JJ
cord-000248-zueoyesj	898	11	human	human	JJ
cord-000248-zueoyesj	898	12	lobular	lobular	NNP
cord-000248-zueoyesj	898	13	breast	breast	NN
cord-000248-zueoyesj	898	14	cancer	cancer	NN
cord-000248-zueoyesj	898	15	as	as	IN
cord-000248-zueoyesj	898	16	a	a	DT
cord-000248-zueoyesj	898	17	result	result	NN
cord-000248-zueoyesj	898	18	of	of	IN
cord-000248-zueoyesj	898	19	an	an	DT
cord-000248-zueoyesj	898	20	analysis	analysis	NN
cord-000248-zueoyesj	898	21	of	of	IN
cord-000248-zueoyesj	898	22	over	over	IN
cord-000248-zueoyesj	898	23	132,000	132,000	CD
cord-000248-zueoyesj	898	24	Roche	Roche	NNP
cord-000248-zueoyesj	898	25	454	454	CD
cord-000248-zueoyesj	898	26	high	high	JJ
cord-000248-zueoyesj	898	27	-	-	HYPH
cord-000248-zueoyesj	898	28	confidence	confidence	NN
cord-000248-zueoyesj	898	29	deep	deep	JJ
cord-000248-zueoyesj	898	30	sequencing	sequencing	NN
cord-000248-zueoyesj	898	31	reads	read	NNS
cord-000248-zueoyesj	898	32	.	.	.
cord-000248-zueoyesj	899	1	Within	within	IN
cord-000248-zueoyesj	899	2	the	the	DT
cord-000248-zueoyesj	899	3	thousands	thousand	NNS
cord-000248-zueoyesj	899	4	of	of	IN
cord-000248-zueoyesj	899	5	novel	novel	JJ
cord-000248-zueoyesj	899	6	non	non	JJ
cord-000248-zueoyesj	899	7	-	-	JJ
cord-000248-zueoyesj	899	8	coding	coding	JJ
cord-000248-zueoyesj	899	9	transcripts	transcript	NNS
cord-000248-zueoyesj	899	10	of	of	IN
cord-000248-zueoyesj	899	11	the	the	DT
cord-000248-zueoyesj	899	12	breast	breast	NN
cord-000248-zueoyesj	899	13	cancer	cancer	NN
cord-000248-zueoyesj	899	14	transcriptome	transcriptome	NN
cord-000248-zueoyesj	899	15	,	,	,
cord-000248-zueoyesj	899	16	Guffanti	Guffanti	NNP
cord-000248-zueoyesj	899	17	al	al	NNP
cord-000248-zueoyesj	899	18	.	.	NNP
cord-000248-zueoyesj	899	19	,	,	,
cord-000248-zueoyesj	899	20	identified	identify	VBD
cord-000248-zueoyesj	899	21	more	more	JJR
cord-000248-zueoyesj	899	22	than	than	IN
cord-000248-zueoyesj	899	23	three	three	CD
cord-000248-zueoyesj	899	24	hundred	hundred	CD
cord-000248-zueoyesj	899	25	reads	read	VBZ
cord-000248-zueoyesj	899	26	corresponding	correspond	VBG
cord-000248-zueoyesj	899	27	to	to	IN
cord-000248-zueoyesj	899	28	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	899	29	[	[	-LRB-
cord-000248-zueoyesj	899	30	749	749	CD
cord-000248-zueoyesj	899	31	]	]	-RRB-
cord-000248-zueoyesj	899	32	.	.	.
cord-000248-zueoyesj	900	1	This	this	DT
cord-000248-zueoyesj	900	2	non	non	JJ
cord-000248-zueoyesj	900	3	-	-	JJ
cord-000248-zueoyesj	900	4	coding	coding	JJ
cord-000248-zueoyesj	900	5	RNA	RNA	NNP
cord-000248-zueoyesj	900	6	,	,	,
cord-000248-zueoyesj	900	7	first	first	RB
cord-000248-zueoyesj	900	8	identified	identify	VBN
cord-000248-zueoyesj	900	9	in	in	IN
cord-000248-zueoyesj	900	10	2003	2003	CD
cord-000248-zueoyesj	900	11	in	in	IN
cord-000248-zueoyesj	900	12	non	non	JJ
cord-000248-zueoyesj	900	13	-	-	JJ
cord-000248-zueoyesj	900	14	small	small	JJ
cord-000248-zueoyesj	900	15	cell	cell	NN
cord-000248-zueoyesj	900	16	lung	lung	NN
cord-000248-zueoyesj	900	17	cancer	cancer	NN
cord-000248-zueoyesj	900	18	,	,	,
cord-000248-zueoyesj	900	19	was	be	VBD
cord-000248-zueoyesj	900	20	shown	show	VBN
cord-000248-zueoyesj	900	21	to	to	TO
cord-000248-zueoyesj	900	22	be	be	VB
cord-000248-zueoyesj	900	23	highly	highly	RB
cord-000248-zueoyesj	900	24	expressed	express	VBN
cord-000248-zueoyesj	900	25	(	(	-LRB-
cord-000248-zueoyesj	900	26	relative	relative	JJ
cord-000248-zueoyesj	900	27	to	to	IN
cord-000248-zueoyesj	900	28	GAPDH	GAPDH	NNP
cord-000248-zueoyesj	900	29	)	)	-RRB-
cord-000248-zueoyesj	900	30	in	in	IN
cord-000248-zueoyesj	900	31	lung	lung	NN
cord-000248-zueoyesj	900	32	,	,	,
cord-000248-zueoyesj	900	33	pancreas	pancreas	NN
cord-000248-zueoyesj	900	34	and	and	CC
cord-000248-zueoyesj	900	35	prostate	prostate	NN
cord-000248-zueoyesj	900	36	,	,	,
cord-000248-zueoyesj	900	37	but	but	CC
cord-000248-zueoyesj	900	38	not	not	RB
cord-000248-zueoyesj	900	39	in	in	IN
cord-000248-zueoyesj	900	40	other	other	JJ
cord-000248-zueoyesj	900	41	tissues	tissue	NNS
cord-000248-zueoyesj	900	42	including	include	VBG
cord-000248-zueoyesj	900	43	muscle	muscle	NN
cord-000248-zueoyesj	900	44	,	,	,
cord-000248-zueoyesj	900	45	skin	skin	NN
cord-000248-zueoyesj	900	46	,	,	,
cord-000248-zueoyesj	900	47	stomach	stomach	NN
cord-000248-zueoyesj	900	48	,	,	,
cord-000248-zueoyesj	900	49	bone	bone	NN
cord-000248-zueoyesj	900	50	marrow	marrow	NN
cord-000248-zueoyesj	900	51	,	,	,
cord-000248-zueoyesj	900	52	saliva	saliva	NN
cord-000248-zueoyesj	900	53	,	,	,
cord-000248-zueoyesj	900	54	thyroid	thyroid	NN
cord-000248-zueoyesj	900	55	and	and	CC
cord-000248-zueoyesj	900	56	adrenal	adrenal	JJ
cord-000248-zueoyesj	900	57	glands	gland	NNS
cord-000248-zueoyesj	900	58	,	,	,
cord-000248-zueoyesj	900	59	uterus	uterus	NN
cord-000248-zueoyesj	900	60	and	and	CC
cord-000248-zueoyesj	900	61	fetal	fetal	JJ
cord-000248-zueoyesj	900	62	liver	liver	NN
cord-000248-zueoyesj	900	63	(	(	-LRB-
cord-000248-zueoyesj	900	64	see	see	VB
cord-000248-zueoyesj	900	65	figure	figure	NN
cord-000248-zueoyesj	900	66	four	four	CD
cord-000248-zueoyesj	900	67	of	of	IN
cord-000248-zueoyesj	900	68	Ref	Ref	NNP
cord-000248-zueoyesj	900	69	.	.	.
cord-000248-zueoyesj	901	1	[	[	-LRB-
cord-000248-zueoyesj	901	2	758	758	CD
cord-000248-zueoyesj	901	3	]	]	-RRB-
cord-000248-zueoyesj	901	4	)	)	-RRB-
cord-000248-zueoyesj	901	5	.	.	.
cord-000248-zueoyesj	902	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	902	2	results	result	NNS
cord-000248-zueoyesj	902	3	indicate	indicate	VBP
cord-000248-zueoyesj	902	4	that	that	IN
cord-000248-zueoyesj	902	5	the	the	DT
cord-000248-zueoyesj	902	6	reduction	reduction	NN
cord-000248-zueoyesj	902	7	of	of	IN
cord-000248-zueoyesj	902	8	expression	expression	NN
cord-000248-zueoyesj	902	9	of	of	IN
cord-000248-zueoyesj	902	10	some	some	DT
cord-000248-zueoyesj	902	11	non	non	JJ
cord-000248-zueoyesj	902	12	-	-	JJ
cord-000248-zueoyesj	902	13	coding	coding	JJ
cord-000248-zueoyesj	902	14	RNAs	rna	NNS
cord-000248-zueoyesj	902	15	,	,	,
cord-000248-zueoyesj	902	16	in	in	IN
cord-000248-zueoyesj	902	17	particular	particular	JJ
cord-000248-zueoyesj	902	18	of	of	IN
cord-000248-zueoyesj	902	19	MALAT-1	MALAT-1	NNS
cord-000248-zueoyesj	902	20	,	,	,
cord-000248-zueoyesj	902	21	and	and	CC
cord-000248-zueoyesj	902	22	SNORA60	SNORA60	NNP
cord-000248-zueoyesj	902	23	with	with	IN
cord-000248-zueoyesj	902	24	respect	respect	NN
cord-000248-zueoyesj	902	25	to	to	IN
cord-000248-zueoyesj	902	26	their	-PRON-	PRP$
cord-000248-zueoyesj	902	27	normal	normal	JJ
cord-000248-zueoyesj	902	28	expression	expression	NN
cord-000248-zueoyesj	902	29	in	in	IN
cord-000248-zueoyesj	902	30	prostate	prostate	NN
cord-000248-zueoyesj	902	31	,	,	,
cord-000248-zueoyesj	902	32	as	as	RB
cord-000248-zueoyesj	902	33	well	well	RB
cord-000248-zueoyesj	902	34	as	as	IN
cord-000248-zueoyesj	902	35	the	the	DT
cord-000248-zueoyesj	902	36	upregulation	upregulation	NN
cord-000248-zueoyesj	902	37	of	of	IN
cord-000248-zueoyesj	902	38	SNHG8	snhg8	NN
cord-000248-zueoyesj	903	1	and	and	CC
cord-000248-zueoyesj	903	2	SNHG1	SNHG1	NNP
cord-000248-zueoyesj	903	3	should	should	MD
cord-000248-zueoyesj	903	4	be	be	VB
cord-000248-zueoyesj	903	5	monitored	monitor	VBN
cord-000248-zueoyesj	903	6	as	as	IN
cord-000248-zueoyesj	903	7	useful	useful	JJ
cord-000248-zueoyesj	903	8	biomarkers	biomarker	NNS
cord-000248-zueoyesj	903	9	to	to	TO
cord-000248-zueoyesj	903	10	track	track	VB
cord-000248-zueoyesj	903	11	disease	disease	NN
cord-000248-zueoyesj	903	12	staging	staging	NN
cord-000248-zueoyesj	903	13	and	and	CC
cord-000248-zueoyesj	903	14	progression	progression	NN
cord-000248-zueoyesj	903	15	to	to	IN
cord-000248-zueoyesj	903	16	a	a	DT
cord-000248-zueoyesj	903	17	more	more	RBR
cord-000248-zueoyesj	903	18	malignant	malignant	JJ
cord-000248-zueoyesj	903	19	phenotype	phenotype	NN
cord-000248-zueoyesj	903	20	.	.	.
cord-000248-zueoyesj	904	1	Interestingly	interestingly	RB
cord-000248-zueoyesj	904	2	enough	enough	RB
cord-000248-zueoyesj	904	3	,	,	,
cord-000248-zueoyesj	904	4	a	a	DT
cord-000248-zueoyesj	904	5	study	study	NN
cord-000248-zueoyesj	904	6	published	publish	VBN
cord-000248-zueoyesj	904	7	in	in	IN
cord-000248-zueoyesj	904	8	2006	2006	CD
cord-000248-zueoyesj	904	9	by	by	IN
cord-000248-zueoyesj	904	10	Nadminty	Nadminty	NNP
cord-000248-zueoyesj	904	11	et	et	NNP
cord-000248-zueoyesj	904	12	al	al	NNP
cord-000248-zueoyesj	904	13	.	.	NNP
cord-000248-zueoyesj	904	14	has	have	VBZ
cord-000248-zueoyesj	904	15	shown	show	VBN
cord-000248-zueoyesj	904	16	that	that	IN
cord-000248-zueoyesj	904	17	KLK3	KLK3	NNP
cord-000248-zueoyesj	904	18	/	/	SYM
cord-000248-zueoyesj	904	19	PSA	PSA	NNP
cord-000248-zueoyesj	904	20	modulates	modulate	VBZ
cord-000248-zueoyesj	904	21	several	several	JJ
cord-000248-zueoyesj	904	22	genes	gene	NNS
cord-000248-zueoyesj	904	23	,	,	,
cord-000248-zueoyesj	904	24	reporting	report	VBG
cord-000248-zueoyesj	904	25	a	a	DT
cord-000248-zueoyesj	904	26	16.5	16.5	CD
cord-000248-zueoyesj	904	27	fold	fold	JJ
cord-000248-zueoyesj	904	28	downregulation	downregulation	NN
cord-000248-zueoyesj	904	29	of	of	IN
cord-000248-zueoyesj	904	30	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	904	31	[	[	-LRB-
cord-000248-zueoyesj	904	32	810	810	CD
cord-000248-zueoyesj	904	33	]	]	-RRB-
cord-000248-zueoyesj	904	34	.	.	.
cord-000248-zueoyesj	905	1	While	while	IN
cord-000248-zueoyesj	905	2	these	these	DT
cord-000248-zueoyesj	905	3	results	result	NNS
cord-000248-zueoyesj	905	4	have	have	VBP
cord-000248-zueoyesj	905	5	been	be	VBN
cord-000248-zueoyesj	905	6	obtained	obtain	VBN
cord-000248-zueoyesj	905	7	using	use	VBG
cord-000248-zueoyesj	905	8	the	the	DT
cord-000248-zueoyesj	905	9	human	human	JJ
cord-000248-zueoyesj	905	10	osteosarcoma	osteosarcoma	NN
cord-000248-zueoyesj	905	11	cell	cell	NN
cord-000248-zueoyesj	905	12	line	line	NN
cord-000248-zueoyesj	905	13	SaOS-2	SaOS-2	NNP
cord-000248-zueoyesj	905	14	,	,	,
cord-000248-zueoyesj	905	15	our	-PRON-	PRP$
cord-000248-zueoyesj	905	16	results	result	NNS
cord-000248-zueoyesj	905	17	indicate	indicate	VBP
cord-000248-zueoyesj	905	18	that	that	IN
cord-000248-zueoyesj	905	19	MALAT1	MALAT1	NNP
cord-000248-zueoyesj	905	20	expression	expression	NN
cord-000248-zueoyesj	905	21	in	in	IN
cord-000248-zueoyesj	905	22	the	the	DT
cord-000248-zueoyesj	905	23	normal	normal	JJ
cord-000248-zueoyesj	905	24	prostate	prostate	NN
cord-000248-zueoyesj	905	25	and	and	CC
cord-000248-zueoyesj	905	26	in	in	IN
cord-000248-zueoyesj	905	27	cancer	cancer	NN
cord-000248-zueoyesj	905	28	cells	cell	NNS
cord-000248-zueoyesj	905	29	could	could	MD
cord-000248-zueoyesj	905	30	also	also	RB
cord-000248-zueoyesj	905	31	be	be	VB
cord-000248-zueoyesj	905	32	considered	consider	VBN
cord-000248-zueoyesj	905	33	as	as	IN
cord-000248-zueoyesj	905	34	a	a	DT
cord-000248-zueoyesj	905	35	relevant	relevant	JJ
cord-000248-zueoyesj	905	36	biomarkers	biomarker	NNS
cord-000248-zueoyesj	905	37	to	to	TO
cord-000248-zueoyesj	905	38	be	be	VB
cord-000248-zueoyesj	905	39	tested	test	VBN
cord-000248-zueoyesj	905	40	in	in	IN
cord-000248-zueoyesj	905	41	the	the	DT
cord-000248-zueoyesj	905	42	future	future	NN
cord-000248-zueoyesj	905	43	.	.	.
cord-000248-zueoyesj	906	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	907	1	/journal.pone.0012262.g020	/journal.pone.0012262.g020	NFP
cord-000248-zueoyesj	907	2	patterns	pattern	NNS
cord-000248-zueoyesj	907	3	4	4	CD
cord-000248-zueoyesj	907	4	and	and	CC
cord-000248-zueoyesj	907	5	5	5	CD
cord-000248-zueoyesj	907	6	(	(	-LRB-
cord-000248-zueoyesj	907	7	two	two	CD
cord-000248-zueoyesj	907	8	patterns	pattern	NNS
cord-000248-zueoyesj	907	9	which	which	WDT
cord-000248-zueoyesj	907	10	are	be	VBP
cord-000248-zueoyesj	907	11	typically	typically	RB
cord-000248-zueoyesj	907	12	associated	associate	VBN
cord-000248-zueoyesj	907	13	to	to	IN
cord-000248-zueoyesj	907	14	an	an	DT
cord-000248-zueoyesj	907	15	aggressive	aggressive	JJ
cord-000248-zueoyesj	907	16	phenotype	phenotype	NN
cord-000248-zueoyesj	907	17	)	)	-RRB-
cord-000248-zueoyesj	907	18	have	have	VBP
cord-000248-zueoyesj	907	19	lower	low	JJR
cord-000248-zueoyesj	907	20	Normalized	Normalized	NNP
cord-000248-zueoyesj	907	21	Shannon	Shannon	NNP
cord-000248-zueoyesj	907	22	Entropy	Entropy	NNP
cord-000248-zueoyesj	907	23	values	value	NNS
cord-000248-zueoyesj	907	24	than	than	IN
cord-000248-zueoyesj	907	25	a	a	DT
cord-000248-zueoyesj	907	26	subset	subset	NN
cord-000248-zueoyesj	907	27	of	of	IN
cord-000248-zueoyesj	907	28	Gleason	Gleason	NNP
cord-000248-zueoyesj	907	29	pattern	pattern	NN
cord-000248-zueoyesj	907	30	3	3	CD
cord-000248-zueoyesj	907	31	(	(	-LRB-
cord-000248-zueoyesj	907	32	a	a	DT
cord-000248-zueoyesj	907	33	pattern	pattern	NN
cord-000248-zueoyesj	907	34	which	which	WDT
cord-000248-zueoyesj	907	35	is	be	VBZ
cord-000248-zueoyesj	907	36	normally	normally	RB
cord-000248-zueoyesj	907	37	associated	associate	VBN
cord-000248-zueoyesj	907	38	to	to	IN
cord-000248-zueoyesj	907	39	a	a	DT
cord-000248-zueoyesj	907	40	less	less	RBR
cord-000248-zueoyesj	907	41	aggressive	aggressive	JJ
cord-000248-zueoyesj	907	42	phenotype	phenotype	NN
cord-000248-zueoyesj	908	1	but	but	CC
cord-000248-zueoyesj	908	2	which	which	WDT
cord-000248-zueoyesj	908	3	nevertheless	nevertheless	RB
cord-000248-zueoyesj	908	4	is	be	VBZ
cord-000248-zueoyesj	908	5	still	still	RB
cord-000248-zueoyesj	908	6	of	of	IN
cord-000248-zueoyesj	908	7	clinical	clinical	JJ
cord-000248-zueoyesj	908	8	concern	concern	NN
cord-000248-zueoyesj	908	9	)	)	-RRB-
cord-000248-zueoyesj	908	10	.	.	.
cord-000248-zueoyesj	909	1	However	however	RB
cord-000248-zueoyesj	909	2	,	,	,
cord-000248-zueoyesj	909	3	a	a	DT
cord-000248-zueoyesj	909	4	group	group	NN
cord-000248-zueoyesj	909	5	of	of	IN
cord-000248-zueoyesj	909	6	samples	sample	NNS
cord-000248-zueoyesj	909	7	having	have	VBG
cord-000248-zueoyesj	909	8	Gleason	Gleason	NNP
cord-000248-zueoyesj	909	9	patterns	pattern	NNS
cord-000248-zueoyesj	909	10	3	3	CD
cord-000248-zueoyesj	909	11	,	,	,
cord-000248-zueoyesj	909	12	4	4	CD
cord-000248-zueoyesj	909	13	,	,	,
cord-000248-zueoyesj	909	14	and	and	CC
cord-000248-zueoyesj	909	15	5	5	CD
cord-000248-zueoyesj	909	16	is	be	VBZ
cord-000248-zueoyesj	909	17	revealed	reveal	VBN
cord-000248-zueoyesj	909	18	;	;	:
cord-000248-zueoyesj	909	19	this	this	DT
cord-000248-zueoyesj	909	20	mixed	mixed	JJ
cord-000248-zueoyesj	909	21	cluster	cluster	NN
cord-000248-zueoyesj	909	22	has	have	VBZ
cord-000248-zueoyesj	909	23	a	a	DT
cord-000248-zueoyesj	909	24	mid	mid	JJ
cord-000248-zueoyesj	909	25	-	-	JJ
cord-000248-zueoyesj	909	26	range	range	JJ
cord-000248-zueoyesj	909	27	entropy	entropy	NN
cord-000248-zueoyesj	909	28	.	.	.
cord-000248-zueoyesj	910	1	This	this	DT
cord-000248-zueoyesj	910	2	is	be	VBZ
cord-000248-zueoyesj	910	3	an	an	DT
cord-000248-zueoyesj	910	4	interesting	interesting	JJ
cord-000248-zueoyesj	910	5	fact	fact	NN
cord-000248-zueoyesj	910	6	which	which	WDT
cord-000248-zueoyesj	910	7	correlates	correlate	VBZ
cord-000248-zueoyesj	910	8	with	with	IN
cord-000248-zueoyesj	910	9	the	the	DT
cord-000248-zueoyesj	910	10	limitations	limitation	NNS
cord-000248-zueoyesj	910	11	observed	observe	VBN
cord-000248-zueoyesj	910	12	in	in	IN
cord-000248-zueoyesj	910	13	Ref	Ref	NNP
cord-000248-zueoyesj	910	14	.	.	.
cord-000248-zueoyesj	911	1	[	[	-LRB-
cord-000248-zueoyesj	911	2	332	332	CD
cord-000248-zueoyesj	911	3	]	]	-RRB-
cord-000248-zueoyesj	911	4	.	.	.
cord-000248-zueoyesj	912	1	We	-PRON-	PRP
cord-000248-zueoyesj	912	2	note	note	VBP
cord-000248-zueoyesj	912	3	the	the	DT
cord-000248-zueoyesj	912	4	authors	author	NNS
cord-000248-zueoyesj	912	5	'	'	POS
cord-000248-zueoyesj	912	6	comment	comment	NN
cord-000248-zueoyesj	912	7	:	:	:
cord-000248-zueoyesj	912	8	'	'	''
cord-000248-zueoyesj	912	9	'	'	''
cord-000248-zueoyesj	912	10	We	-PRON-	PRP
cord-000248-zueoyesj	912	11	were	be	VBD
cord-000248-zueoyesj	912	12	unable	unable	JJ
cord-000248-zueoyesj	912	13	to	to	TO
cord-000248-zueoyesj	912	14	identify	identify	VB
cord-000248-zueoyesj	912	15	a	a	DT
cord-000248-zueoyesj	912	16	cohort	cohort	NN
cord-000248-zueoyesj	912	17	of	of	IN
cord-000248-zueoyesj	912	18	genes	gene	NNS
cord-000248-zueoyesj	912	19	that	that	WDT
cord-000248-zueoyesj	912	20	could	could	MD
cord-000248-zueoyesj	912	21	distinguish	distinguish	VB
cord-000248-zueoyesj	912	22	between	between	IN
cord-000248-zueoyesj	912	23	pattern	pattern	NN
cord-000248-zueoyesj	912	24	4	4	CD
cord-000248-zueoyesj	912	25	and	and	CC
cord-000248-zueoyesj	912	26	5	5	CD
cord-000248-zueoyesj	912	27	cancers	cancer	NNS
cord-000248-zueoyesj	912	28	with	with	IN
cord-000248-zueoyesj	912	29	sufficiently	sufficiently	RB
cord-000248-zueoyesj	912	30	high	high	JJ
cord-000248-zueoyesj	912	31	accuracy	accuracy	NN
cord-000248-zueoyesj	912	32	to	to	TO
cord-000248-zueoyesj	912	33	be	be	VB
cord-000248-zueoyesj	912	34	useful	useful	JJ
cord-000248-zueoyesj	912	35	,	,	,
cord-000248-zueoyesj	912	36	suggesting	suggest	VBG
cord-000248-zueoyesj	912	37	a	a	DT
cord-000248-zueoyesj	912	38	high	high	JJ
cord-000248-zueoyesj	912	39	degree	degree	NN
cord-000248-zueoyesj	912	40	of	of	IN
cord-000248-zueoyesj	912	41	similarity	similarity	NN
cord-000248-zueoyesj	912	42	between	between	IN
cord-000248-zueoyesj	912	43	these	these	DT
cord-000248-zueoyesj	912	44	cancer	cancer	NN
cord-000248-zueoyesj	912	45	histologies	histology	NNS
cord-000248-zueoyesj	912	46	or	or	CC
cord-000248-zueoyesj	912	47	substantial	substantial	JJ
cord-000248-zueoyesj	912	48	molecular	molecular	JJ
cord-000248-zueoyesj	912	49	heterogeneity	heterogeneity	NN
cord-000248-zueoyesj	912	50	in	in	IN
cord-000248-zueoyesj	912	51	one	one	CD
cord-000248-zueoyesj	912	52	or	or	CC
cord-000248-zueoyesj	912	53	both	both	DT
cord-000248-zueoyesj	912	54	of	of	IN
cord-000248-zueoyesj	912	55	these	these	DT
cord-000248-zueoyesj	912	56	groups	group	NNS
cord-000248-zueoyesj	912	57	.	.	.
cord-000248-zueoyesj	912	58	'	'	''
cord-000248-zueoyesj	913	1	'	'	''
cord-000248-zueoyesj	914	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	914	2	results	result	NNS
cord-000248-zueoyesj	914	3	provide	provide	VBP
cord-000248-zueoyesj	914	4	a	a	DT
cord-000248-zueoyesj	914	5	conciliatory	conciliatory	JJ
cord-000248-zueoyesj	914	6	middle	middle	JJ
cord-000248-zueoyesj	914	7	ground	ground	NN
cord-000248-zueoyesj	914	8	that	that	WDT
cord-000248-zueoyesj	914	9	explains	explain	VBZ
cord-000248-zueoyesj	914	10	the	the	DT
cord-000248-zueoyesj	914	11	perceived	perceive	VBN
cord-000248-zueoyesj	914	12	clinical	clinical	JJ
cord-000248-zueoyesj	914	13	usefulness	usefulness	NN
cord-000248-zueoyesj	914	14	of	of	IN
cord-000248-zueoyesj	914	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	914	16	pattern	pattern	NN
cord-000248-zueoyesj	914	17	classification	classification	NN
cord-000248-zueoyesj	914	18	,	,	,
cord-000248-zueoyesj	914	19	widely	widely	RB
cord-000248-zueoyesj	914	20	used	use	VBN
cord-000248-zueoyesj	914	21	around	around	IN
cord-000248-zueoyesj	914	22	the	the	DT
cord-000248-zueoyesj	914	23	world	world	NN
cord-000248-zueoyesj	914	24	,	,	,
cord-000248-zueoyesj	914	25	while	while	IN
cord-000248-zueoyesj	914	26	at	at	IN
cord-000248-zueoyesj	914	27	the	the	DT
cord-000248-zueoyesj	914	28	same	same	JJ
cord-000248-zueoyesj	914	29	time	time	NN
cord-000248-zueoyesj	914	30	reveals	reveal	VBZ
cord-000248-zueoyesj	914	31	the	the	DT
cord-000248-zueoyesj	914	32	reason	reason	NN
cord-000248-zueoyesj	914	33	for	for	IN
cord-000248-zueoyesj	914	34	the	the	DT
cord-000248-zueoyesj	914	35	difficulties	difficulty	NNS
cord-000248-zueoyesj	914	36	of	of	IN
cord-000248-zueoyesj	914	37	obtaining	obtain	VBG
cord-000248-zueoyesj	914	38	a	a	DT
cord-000248-zueoyesj	914	39	good	good	JJ
cord-000248-zueoyesj	914	40	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	914	41	signature	signature	NN
cord-000248-zueoyesj	914	42	for	for	IN
cord-000248-zueoyesj	914	43	the	the	DT
cord-000248-zueoyesj	914	44	other	other	JJ
cord-000248-zueoyesj	914	45	two	two	CD
cord-000248-zueoyesj	914	46	patterns	pattern	NNS
cord-000248-zueoyesj	914	47	[	[	-LRB-
cord-000248-zueoyesj	914	48	791	791	CD
cord-000248-zueoyesj	914	49	]	]	-RRB-
cord-000248-zueoyesj	914	50	.	.	.
cord-000248-zueoyesj	915	1	We	-PRON-	PRP
cord-000248-zueoyesj	915	2	have	have	VBP
cord-000248-zueoyesj	915	3	seen	see	VBN
cord-000248-zueoyesj	915	4	,	,	,
cord-000248-zueoyesj	915	5	through	through	IN
cord-000248-zueoyesj	915	6	a	a	DT
cord-000248-zueoyesj	915	7	detailed	detailed	JJ
cord-000248-zueoyesj	915	8	discussion	discussion	NN
cord-000248-zueoyesj	915	9	of	of	IN
cord-000248-zueoyesj	915	10	several	several	JJ
cord-000248-zueoyesj	915	11	biomarkers	biomarker	NNS
cord-000248-zueoyesj	915	12	in	in	IN
cord-000248-zueoyesj	915	13	three	three	CD
cord-000248-zueoyesj	915	14	different	different	JJ
cord-000248-zueoyesj	915	15	datasets	dataset	NNS
cord-000248-zueoyesj	915	16	,	,	,
cord-000248-zueoyesj	915	17	that	that	IN
cord-000248-zueoyesj	915	18	the	the	DT
cord-000248-zueoyesj	915	19	variation	variation	NN
cord-000248-zueoyesj	915	20	of	of	IN
cord-000248-zueoyesj	915	21	the	the	DT
cord-000248-zueoyesj	915	22	gene	gene	NN
cord-000248-zueoyesj	915	23	expression	expression	NN
cord-000248-zueoyesj	915	24	distributional	distributional	JJ
cord-000248-zueoyesj	915	25	profile	profile	NN
cord-000248-zueoyesj	915	26	can	can	MD
cord-000248-zueoyesj	915	27	be	be	VB
cord-000248-zueoyesj	915	28	characterized	characterize	VBN
cord-000248-zueoyesj	915	29	via	via	IN
cord-000248-zueoyesj	915	30	Information	Information	NNP
cord-000248-zueoyesj	915	31	Theory	Theory	NNP
cord-000248-zueoyesj	915	32	quantifiers	quantifier	NNS
cord-000248-zueoyesj	915	33	.	.	.
cord-000248-zueoyesj	916	1	Our	-PRON-	PRP$
cord-000248-zueoyesj	916	2	study	study	NN
cord-000248-zueoyesj	916	3	also	also	RB
cord-000248-zueoyesj	916	4	showed	show	VBD
cord-000248-zueoyesj	916	5	that	that	IN
cord-000248-zueoyesj	916	6	current	current	JJ
cord-000248-zueoyesj	916	7	established	establish	VBN
cord-000248-zueoyesj	916	8	biomarkers	biomarker	NNS
cord-000248-zueoyesj	916	9	of	of	IN
cord-000248-zueoyesj	916	10	the	the	DT
cord-000248-zueoyesj	916	11	two	two	CD
cord-000248-zueoyesj	916	12	diseases	disease	NNS
cord-000248-zueoyesj	916	13	studied	study	VBN
cord-000248-zueoyesj	916	14	seem	seem	VBP
cord-000248-zueoyesj	916	15	to	to	TO
cord-000248-zueoyesj	916	16	correlate	correlate	VB
cord-000248-zueoyesj	916	17	with	with	IN
cord-000248-zueoyesj	916	18	those	those	DT
cord-000248-zueoyesj	916	19	that	that	WDT
cord-000248-zueoyesj	916	20	best	good	JJS
cord-000248-zueoyesj	916	21	co	co	NN
cord-000248-zueoyesj	916	22	-	-	NN
cord-000248-zueoyesj	916	23	variate	variate	VB
cord-000248-zueoyesj	916	24	with	with	IN
cord-000248-zueoyesj	916	25	these	these	DT
cord-000248-zueoyesj	916	26	quantifiers	quantifier	NNS
cord-000248-zueoyesj	916	27	.	.	.
cord-000248-zueoyesj	917	1	For	for	IN
cord-000248-zueoyesj	917	2	instance	instance	NN
cord-000248-zueoyesj	917	3	,	,	,
cord-000248-zueoyesj	917	4	AMACR	AMACR	NNP
cord-000248-zueoyesj	917	5	,	,	,
cord-000248-zueoyesj	917	6	in	in	IN
cord-000248-zueoyesj	917	7	our	-PRON-	PRP$
cord-000248-zueoyesj	917	8	second	second	JJ
cord-000248-zueoyesj	917	9	prostate	prostate	NN
cord-000248-zueoyesj	917	10	cancer	cancer	NN
cord-000248-zueoyesj	917	11	dataset	dataset	NN
cord-000248-zueoyesj	917	12	studied	study	VBD
cord-000248-zueoyesj	917	13	,	,	,
cord-000248-zueoyesj	917	14	naturally	naturally	RB
cord-000248-zueoyesj	917	15	appears	appear	VBZ
cord-000248-zueoyesj	917	16	as	as	IN
cord-000248-zueoyesj	917	17	one	one	CD
cord-000248-zueoyesj	917	18	of	of	IN
cord-000248-zueoyesj	917	19	the	the	DT
cord-000248-zueoyesj	917	20	most	most	RBS
cord-000248-zueoyesj	917	21	correlated	correlate	VBN
cord-000248-zueoyesj	917	22	genes	gene	NNS
cord-000248-zueoyesj	917	23	(	(	-LRB-
cord-000248-zueoyesj	917	24	in	in	IN
cord-000248-zueoyesj	917	25	both	both	CC
cord-000248-zueoyesj	917	26	the	the	DT
cord-000248-zueoyesj	917	27	Pearson	Pearson	NNP
cord-000248-zueoyesj	917	28	and	and	CC
cord-000248-zueoyesj	917	29	the	the	DT
cord-000248-zueoyesj	917	30	Spearman	Spearman	NNP
cord-000248-zueoyesj	917	31	sense	sense	NN
cord-000248-zueoyesj	917	32	)	)	-RRB-
cord-000248-zueoyesj	917	33	with	with	IN
cord-000248-zueoyesj	917	34	the	the	DT
cord-000248-zueoyesj	917	35	pattern	pattern	NN
cord-000248-zueoyesj	917	36	of	of	IN
cord-000248-zueoyesj	917	37	variation	variation	NN
cord-000248-zueoyesj	917	38	of	of	IN
cord-000248-zueoyesj	917	39	Entropy	Entropy	NNP
cord-000248-zueoyesj	917	40	of	of	IN
cord-000248-zueoyesj	917	41	the	the	DT
cord-000248-zueoyesj	917	42	samples	sample	NNS
cord-000248-zueoyesj	917	43	.	.	.
cord-000248-zueoyesj	918	1	Together	together	RB
cord-000248-zueoyesj	918	2	with	with	IN
cord-000248-zueoyesj	918	3	MAOA	MAOA	NNP
cord-000248-zueoyesj	918	4	,	,	,
cord-000248-zueoyesj	918	5	which	which	WDT
cord-000248-zueoyesj	918	6	is	be	VBZ
cord-000248-zueoyesj	918	7	the	the	DT
cord-000248-zueoyesj	918	8	highlighted	highlight	VBN
cord-000248-zueoyesj	918	9	gene	gene	NN
cord-000248-zueoyesj	918	10	in	in	IN
cord-000248-zueoyesj	918	11	True	True	NNP
cord-000248-zueoyesj	918	12	et	et	NNP
cord-000248-zueoyesj	918	13	al	al	NNP
cord-000248-zueoyesj	918	14	.	.	NNP
cord-000248-zueoyesj	918	15	's	's	POS
cord-000248-zueoyesj	918	16	[	[	-LRB-
cord-000248-zueoyesj	918	17	332	332	CD
cord-000248-zueoyesj	918	18	]	]	-RRB-
cord-000248-zueoyesj	918	19	original	original	JJ
cord-000248-zueoyesj	918	20	publication	publication	NN
cord-000248-zueoyesj	918	21	,	,	,
cord-000248-zueoyesj	918	22	AMACR	AMACR	NNP
cord-000248-zueoyesj	918	23	is	be	VBZ
cord-000248-zueoyesj	918	24	now	now	RB
cord-000248-zueoyesj	918	25	being	be	VBG
cord-000248-zueoyesj	918	26	recognized	recognize	VBN
cord-000248-zueoyesj	918	27	as	as	IN
cord-000248-zueoyesj	918	28	one	one	CD
cord-000248-zueoyesj	918	29	of	of	IN
cord-000248-zueoyesj	918	30	the	the	DT
cord-000248-zueoyesj	918	31	best	good	JJS
cord-000248-zueoyesj	918	32	biomarkers	biomarker	NNS
cord-000248-zueoyesj	918	33	in	in	IN
cord-000248-zueoyesj	918	34	primary	primary	JJ
cord-000248-zueoyesj	918	35	prostate	prostate	NN
cord-000248-zueoyesj	918	36	cancer	cancer	NN
cord-000248-zueoyesj	918	37	with	with	IN
cord-000248-zueoyesj	918	38	approximately	approximately	RB
cord-000248-zueoyesj	918	39	180	180	CD
cord-000248-zueoyesj	918	40	publications	publication	NNS
cord-000248-zueoyesj	918	41	dedicated	dedicate	VBN
cord-000248-zueoyesj	918	42	to	to	IN
cord-000248-zueoyesj	918	43	it	-PRON-	PRP
cord-000248-zueoyesj	918	44	in	in	IN
cord-000248-zueoyesj	918	45	the	the	DT
cord-000248-zueoyesj	918	46	past	past	JJ
cord-000248-zueoyesj	918	47	five	five	CD
cord-000248-zueoyesj	918	48	years	year	NNS
cord-000248-zueoyesj	918	49	.	.	.
cord-000248-zueoyesj	919	1	We	-PRON-	PRP
cord-000248-zueoyesj	919	2	have	have	VBP
cord-000248-zueoyesj	919	3	also	also	RB
cord-000248-zueoyesj	919	4	shown	show	VBN
cord-000248-zueoyesj	919	5	that	that	IN
cord-000248-zueoyesj	919	6	many	many	JJ
cord-000248-zueoyesj	919	7	gene	gene	NN
cord-000248-zueoyesj	919	8	probes	probe	NNS
cord-000248-zueoyesj	919	9	that	that	WDT
cord-000248-zueoyesj	919	10	best	well	RBS
cord-000248-zueoyesj	919	11	correlate	correlate	VBP
cord-000248-zueoyesj	919	12	with	with	IN
cord-000248-zueoyesj	919	13	the	the	DT
cord-000248-zueoyesj	919	14	divergence	divergence	NN
cord-000248-zueoyesj	919	15	of	of	IN
cord-000248-zueoyesj	919	16	the	the	DT
cord-000248-zueoyesj	919	17	normal	normal	JJ
cord-000248-zueoyesj	919	18	tissue	tissue	NN
cord-000248-zueoyesj	919	19	profile	profile	NN
cord-000248-zueoyesj	919	20	have	have	VBP
cord-000248-zueoyesj	919	21	been	be	VBN
cord-000248-zueoyesj	919	22	identified	identify	VBN
cord-000248-zueoyesj	919	23	as	as	IN
cord-000248-zueoyesj	919	24	useful	useful	JJ
cord-000248-zueoyesj	919	25	biomarkers	biomarker	NNS
cord-000248-zueoyesj	919	26	(	(	-LRB-
cord-000248-zueoyesj	919	27	via	via	IN
cord-000248-zueoyesj	919	28	other	other	JJ
cord-000248-zueoyesj	919	29	accepted	accepted	JJ
cord-000248-zueoyesj	919	30	validation	validation	NN
cord-000248-zueoyesj	919	31	methods	method	NNS
cord-000248-zueoyesj	919	32	)	)	-RRB-
cord-000248-zueoyesj	919	33	.	.	.
cord-000248-zueoyesj	920	1	This	this	DT
cord-000248-zueoyesj	920	2	said	say	VBD
cord-000248-zueoyesj	920	3	,	,	,
cord-000248-zueoyesj	920	4	the	the	DT
cord-000248-zueoyesj	920	5	use	use	NN
cord-000248-zueoyesj	920	6	of	of	IN
cord-000248-zueoyesj	920	7	other	other	JJ
cord-000248-zueoyesj	920	8	sources	source	NNS
cord-000248-zueoyesj	920	9	of	of	IN
cord-000248-zueoyesj	920	10	information	information	NN
cord-000248-zueoyesj	920	11	,	,	,
cord-000248-zueoyesj	920	12	like	like	IN
cord-000248-zueoyesj	920	13	pathway	pathway	NN
cord-000248-zueoyesj	920	14	or	or	CC
cord-000248-zueoyesj	920	15	gene	gene	NN
cord-000248-zueoyesj	920	16	ontology	ontology	NN
cord-000248-zueoyesj	920	17	databases	database	NNS
cord-000248-zueoyesj	920	18	has	have	VBZ
cord-000248-zueoyesj	920	19	lead	lead	VBN
cord-000248-zueoyesj	920	20	as	as	IN
cord-000248-zueoyesj	920	21	to	to	IN
cord-000248-zueoyesj	920	22	the	the	DT
cord-000248-zueoyesj	920	23	identification	identification	NN
cord-000248-zueoyesj	920	24	of	of	IN
cord-000248-zueoyesj	920	25	other	other	JJ
cord-000248-zueoyesj	920	26	cell	cell	NN
cord-000248-zueoyesj	920	27	processes	process	NNS
cord-000248-zueoyesj	920	28	that	that	WDT
cord-000248-zueoyesj	920	29	may	may	MD
cord-000248-zueoyesj	920	30	be	be	VB
cord-000248-zueoyesj	920	31	altered	alter	VBN
cord-000248-zueoyesj	920	32	.	.	.
cord-000248-zueoyesj	921	1	We	-PRON-	PRP
cord-000248-zueoyesj	921	2	have	have	VBP
cord-000248-zueoyesj	921	3	presented	present	VBN
cord-000248-zueoyesj	921	4	a	a	DT
cord-000248-zueoyesj	921	5	unifying	unifying	JJ
cord-000248-zueoyesj	921	6	hallmark	hallmark	NN
cord-000248-zueoyesj	921	7	of	of	IN
cord-000248-zueoyesj	921	8	cancer	cancer	NN
cord-000248-zueoyesj	921	9	,	,	,
cord-000248-zueoyesj	921	10	the	the	DT
cord-000248-zueoyesj	921	11	cancer	cancer	NN
cord-000248-zueoyesj	921	12	cell	cell	NN
cord-000248-zueoyesj	921	13	's	's	POS
cord-000248-zueoyesj	921	14	transcriptome	transcriptome	NN
cord-000248-zueoyesj	921	15	changes	change	VBZ
cord-000248-zueoyesj	921	16	its	-PRON-	PRP$
cord-000248-zueoyesj	921	17	Normalized	Normalized	NNP
cord-000248-zueoyesj	921	18	Shannon	Shannon	NNP
cord-000248-zueoyesj	921	19	Entropy	Entropy	NNP
cord-000248-zueoyesj	921	20	(	(	-LRB-
cord-000248-zueoyesj	921	21	as	as	IN
cord-000248-zueoyesj	921	22	measured	measure	VBN
cord-000248-zueoyesj	921	23	by	by	IN
cord-000248-zueoyesj	921	24	high	high	JJ
cord-000248-zueoyesj	921	25	-	-	HYPH
cord-000248-zueoyesj	921	26	througput	througput	NN
cord-000248-zueoyesj	921	27	technologies	technology	NNS
cord-000248-zueoyesj	921	28	)	)	-RRB-
cord-000248-zueoyesj	921	29	,	,	,
cord-000248-zueoyesj	921	30	while	while	IN
cord-000248-zueoyesj	921	31	it	-PRON-	PRP
cord-000248-zueoyesj	921	32	increments	increment	VBZ
cord-000248-zueoyesj	921	33	its	-PRON-	PRP$
cord-000248-zueoyesj	921	34	physical	physical	JJ
cord-000248-zueoyesj	921	35	Entropy	Entropy	NNP
cord-000248-zueoyesj	921	36	(	(	-LRB-
cord-000248-zueoyesj	921	37	via	via	IN
cord-000248-zueoyesj	921	38	creation	creation	NN
cord-000248-zueoyesj	921	39	of	of	IN
cord-000248-zueoyesj	921	40	states	state	NNS
cord-000248-zueoyesj	921	41	we	-PRON-	PRP
cord-000248-zueoyesj	921	42	might	may	MD
cord-000248-zueoyesj	921	43	not	not	RB
cord-000248-zueoyesj	921	44	measure	measure	VB
cord-000248-zueoyesj	921	45	with	with	IN
cord-000248-zueoyesj	921	46	our	-PRON-	PRP$
cord-000248-zueoyesj	921	47	devices	device	NNS
cord-000248-zueoyesj	921	48	)	)	-RRB-
cord-000248-zueoyesj	921	49	.	.	.
cord-000248-zueoyesj	922	1	This	this	DT
cord-000248-zueoyesj	922	2	hallmark	hallmark	NN
cord-000248-zueoyesj	922	3	allows	allow	VBZ
cord-000248-zueoyesj	922	4	,	,	,
cord-000248-zueoyesj	922	5	via	via	IN
cord-000248-zueoyesj	922	6	the	the	DT
cord-000248-zueoyesj	922	7	use	use	NN
cord-000248-zueoyesj	922	8	of	of	IN
cord-000248-zueoyesj	922	9	the	the	DT
cord-000248-zueoyesj	922	10	Jensen	Jensen	NNP
cord-000248-zueoyesj	922	11	-	-	HYPH
cord-000248-zueoyesj	922	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	922	13	divergence	divergence	NN
cord-000248-zueoyesj	922	14	,	,	,
cord-000248-zueoyesj	922	15	to	to	TO
cord-000248-zueoyesj	922	16	identify	identify	VB
cord-000248-zueoyesj	922	17	the	the	DT
cord-000248-zueoyesj	922	18	arrow	arrow	NN
cord-000248-zueoyesj	922	19	of	of	IN
cord-000248-zueoyesj	922	20	time	time	NN
cord-000248-zueoyesj	922	21	of	of	IN
cord-000248-zueoyesj	922	22	the	the	DT
cord-000248-zueoyesj	922	23	process	process	NN
cord-000248-zueoyesj	922	24	,	,	,
cord-000248-zueoyesj	922	25	and	and	CC
cord-000248-zueoyesj	922	26	helps	help	VBZ
cord-000248-zueoyesj	922	27	to	to	TO
cord-000248-zueoyesj	922	28	map	map	VB
cord-000248-zueoyesj	922	29	the	the	DT
cord-000248-zueoyesj	922	30	phenotypical	phenotypical	JJ
cord-000248-zueoyesj	922	31	and	and	CC
cord-000248-zueoyesj	922	32	molecular	molecular	JJ
cord-000248-zueoyesj	922	33	hallmarks	hallmark	NNS
cord-000248-zueoyesj	922	34	of	of	IN
cord-000248-zueoyesj	922	35	cancer	cancer	NN
cord-000248-zueoyesj	922	36	as	as	IN
cord-000248-zueoyesj	922	37	major	major	JJ
cord-000248-zueoyesj	922	38	converging	converging	JJ
cord-000248-zueoyesj	922	39	trends	trend	NNS
cord-000248-zueoyesj	922	40	of	of	IN
cord-000248-zueoyesj	922	41	the	the	DT
cord-000248-zueoyesj	922	42	transcriptome	transcriptome	NN
cord-000248-zueoyesj	922	43	.	.	.
cord-000248-zueoyesj	923	1	The	the	DT
cord-000248-zueoyesj	923	2	methodology	methodology	NN
cord-000248-zueoyesj	923	3	has	have	VBZ
cord-000248-zueoyesj	923	4	produced	produce	VBN
cord-000248-zueoyesj	923	5	remarkable	remarkable	JJ
cord-000248-zueoyesj	923	6	postdictions	postdiction	NNS
cord-000248-zueoyesj	923	7	and	and	CC
cord-000248-zueoyesj	923	8	retrodictions	retrodiction	NNS
cord-000248-zueoyesj	923	9	that	that	WDT
cord-000248-zueoyesj	923	10	show	show	VBP
cord-000248-zueoyesj	923	11	that	that	IN
cord-000248-zueoyesj	923	12	it	-PRON-	PRP
cord-000248-zueoyesj	923	13	can	can	MD
cord-000248-zueoyesj	923	14	predictively	predictively	RB
cord-000248-zueoyesj	923	15	guide	guide	VB
cord-000248-zueoyesj	923	16	biomarker	biomarker	NN
cord-000248-zueoyesj	923	17	discovery	discovery	NN
cord-000248-zueoyesj	923	18	.	.	.
cord-000248-zueoyesj	924	1	We	-PRON-	PRP
cord-000248-zueoyesj	924	2	refer	refer	VBP
cord-000248-zueoyesj	924	3	the	the	DT
cord-000248-zueoyesj	924	4	reader	reader	NN
cord-000248-zueoyesj	924	5	to	to	IN
cord-000248-zueoyesj	924	6	the	the	DT
cord-000248-zueoyesj	924	7	original	original	JJ
cord-000248-zueoyesj	924	8	publications	publication	NNS
cord-000248-zueoyesj	924	9	for	for	IN
cord-000248-zueoyesj	924	10	details	detail	NNS
cord-000248-zueoyesj	924	11	of	of	IN
cord-000248-zueoyesj	924	12	methods	method	NNS
cord-000248-zueoyesj	924	13	for	for	IN
cord-000248-zueoyesj	924	14	data	datum	NNS
cord-000248-zueoyesj	924	15	collection	collection	NN
cord-000248-zueoyesj	924	16	,	,	,
cord-000248-zueoyesj	924	17	but	but	CC
cord-000248-zueoyesj	924	18	we	-PRON-	PRP
cord-000248-zueoyesj	924	19	highlight	highlight	VBP
cord-000248-zueoyesj	924	20	here	here	RB
cord-000248-zueoyesj	924	21	some	some	DT
cord-000248-zueoyesj	924	22	aspects	aspect	NNS
cord-000248-zueoyesj	924	23	that	that	WDT
cord-000248-zueoyesj	924	24	are	be	VBP
cord-000248-zueoyesj	924	25	important	important	JJ
cord-000248-zueoyesj	924	26	to	to	TO
cord-000248-zueoyesj	924	27	understand	understand	VB
cord-000248-zueoyesj	924	28	the	the	DT
cord-000248-zueoyesj	924	29	data	data	NN
cord-000248-zueoyesj	924	30	generation	generation	NN
cord-000248-zueoyesj	924	31	process	process	NN
cord-000248-zueoyesj	924	32	for	for	IN
cord-000248-zueoyesj	924	33	the	the	DT
cord-000248-zueoyesj	924	34	purpose	purpose	NN
cord-000248-zueoyesj	924	35	of	of	IN
cord-000248-zueoyesj	924	36	our	-PRON-	PRP$
cord-000248-zueoyesj	924	37	analysis	analysis	NN
cord-000248-zueoyesj	924	38	.	.	.
cord-000248-zueoyesj	925	1	Samples	sample	NNS
cord-000248-zueoyesj	925	2	were	be	VBD
cord-000248-zueoyesj	925	3	obtrained	obtraine	VBN
cord-000248-zueoyesj	925	4	from	from	IN
cord-000248-zueoyesj	925	5	radical	radical	JJ
cord-000248-zueoyesj	925	6	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	925	7	surgical	surgical	JJ
cord-000248-zueoyesj	925	8	procedures	procedure	NNS
cord-000248-zueoyesj	925	9	.	.	.
cord-000248-zueoyesj	926	1	Samples	sample	NNS
cord-000248-zueoyesj	926	2	are	be	VBP
cord-000248-zueoyesj	926	3	labelled	label	VBN
cord-000248-zueoyesj	926	4	as	as	IN
cord-000248-zueoyesj	926	5	'	'	''
cord-000248-zueoyesj	926	6	'	'	``
cord-000248-zueoyesj	926	7	tumors	tumor	NNS
cord-000248-zueoyesj	926	8	'	'	''
cord-000248-zueoyesj	926	9	'	'	''
cord-000248-zueoyesj	926	10	if	if	IN
cord-000248-zueoyesj	926	11	they	-PRON-	PRP
cord-000248-zueoyesj	926	12	contain	contain	VBP
cord-000248-zueoyesj	926	13	at	at	IN
cord-000248-zueoyesj	926	14	least	least	RBS
cord-000248-zueoyesj	926	15	90	90	CD
cord-000248-zueoyesj	926	16	%	%	NN
cord-000248-zueoyesj	926	17	of	of	IN
cord-000248-zueoyesj	926	18	cancerous	cancerous	JJ
cord-000248-zueoyesj	926	19	epithelial	epithelial	JJ
cord-000248-zueoyesj	926	20	cells	cell	NNS
cord-000248-zueoyesj	926	21	,	,	,
cord-000248-zueoyesj	926	22	and	and	CC
cord-000248-zueoyesj	926	23	they	-PRON-	PRP
cord-000248-zueoyesj	926	24	were	be	VBD
cord-000248-zueoyesj	926	25	considered	consider	VBN
cord-000248-zueoyesj	926	26	as	as	IN
cord-000248-zueoyesj	926	27	'	'	``
cord-000248-zueoyesj	926	28	'	'	''
cord-000248-zueoyesj	926	29	non	non	JJ
cord-000248-zueoyesj	926	30	-	-	JJ
cord-000248-zueoyesj	926	31	tumor	tumor	JJ
cord-000248-zueoyesj	926	32	'	'	''
cord-000248-zueoyesj	926	33	'	'	''
cord-000248-zueoyesj	926	34	if	if	IN
cord-000248-zueoyesj	926	35	they	-PRON-	PRP
cord-000248-zueoyesj	926	36	contain	contain	VBP
cord-000248-zueoyesj	926	37	no	no	DT
cord-000248-zueoyesj	926	38	tumor	tumor	NN
cord-000248-zueoyesj	926	39	epithelium	epithelium	NN
cord-000248-zueoyesj	926	40	and	and	CC
cord-000248-zueoyesj	926	41	are	be	VBP
cord-000248-zueoyesj	926	42	from	from	IN
cord-000248-zueoyesj	926	43	the	the	DT
cord-000248-zueoyesj	926	44	noncancerous	noncancerous	JJ
cord-000248-zueoyesj	926	45	region	region	NN
cord-000248-zueoyesj	926	46	of	of	IN
cord-000248-zueoyesj	926	47	the	the	DT
cord-000248-zueoyesj	926	48	prostate	prostate	NN
cord-000248-zueoyesj	926	49	.	.	.
cord-000248-zueoyesj	927	1	The	the	DT
cord-000248-zueoyesj	927	2	later	later	JJ
cord-000248-zueoyesj	927	3	samples	sample	NNS
cord-000248-zueoyesj	927	4	were	be	VBD
cord-000248-zueoyesj	927	5	labelled	label	VBN
cord-000248-zueoyesj	927	6	'	'	``
cord-000248-zueoyesj	927	7	'	'	``
cord-000248-zueoyesj	927	8	normals	normal	NNS
cord-000248-zueoyesj	927	9	'	'	''
cord-000248-zueoyesj	927	10	'	'	''
cord-000248-zueoyesj	927	11	although	although	IN
cord-000248-zueoyesj	927	12	the	the	DT
cord-000248-zueoyesj	927	13	authors	author	NNS
cord-000248-zueoyesj	927	14	alert	alert	VBP
cord-000248-zueoyesj	927	15	that	that	IN
cord-000248-zueoyesj	927	16	some	some	DT
cord-000248-zueoyesj	927	17	may	may	MD
cord-000248-zueoyesj	927	18	contain	contain	VB
cord-000248-zueoyesj	927	19	dysplasia	dysplasia	NN
cord-000248-zueoyesj	927	20	.	.	.
cord-000248-zueoyesj	928	1	In	in	IN
cord-000248-zueoyesj	928	2	this	this	DT
cord-000248-zueoyesj	928	3	dataset	dataset	NN
cord-000248-zueoyesj	928	4	,	,	,
cord-000248-zueoyesj	928	5	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	928	6	et	et	FW
cord-000248-zueoyesj	928	7	al	al	NNP
cord-000248-zueoyesj	928	8	.	.	NNP
cord-000248-zueoyesj	928	9	have	have	VBP
cord-000248-zueoyesj	928	10	performed	perform	VBN
cord-000248-zueoyesj	928	11	a	a	DT
cord-000248-zueoyesj	928	12	gene	gene	NN
cord-000248-zueoyesj	928	13	expression	expression	NN
cord-000248-zueoyesj	928	14	profiling	profiling	NN
cord-000248-zueoyesj	928	15	by	by	IN
cord-000248-zueoyesj	928	16	using	use	VBG
cord-000248-zueoyesj	928	17	cDNA	cdna	NN
cord-000248-zueoyesj	928	18	microarrays	microarray	NNS
cord-000248-zueoyesj	928	19	containing	contain	VBG
cord-000248-zueoyesj	928	20	26,260	26,260	CD
cord-000248-zueoyesj	928	21	different	different	JJ
cord-000248-zueoyesj	928	22	human	human	JJ
cord-000248-zueoyesj	928	23	genes	gene	NNS
cord-000248-zueoyesj	928	24	(	(	-LRB-
cord-000248-zueoyesj	928	25	UniGene	UniGene	NNP
cord-000248-zueoyesj	928	26	clusters	cluster	NNS
cord-000248-zueoyesj	928	27	)	)	-RRB-
cord-000248-zueoyesj	928	28	.	.	.
cord-000248-zueoyesj	929	1	Using	use	VBG
cord-000248-zueoyesj	929	2	50	50	CD
cord-000248-zueoyesj	929	3	mg	mg	NNS
cord-000248-zueoyesj	929	4	of	of	IN
cord-000248-zueoyesj	929	5	total	total	JJ
cord-000248-zueoyesj	929	6	RNA	RNA	NNP
cord-000248-zueoyesj	929	7	from	from	IN
cord-000248-zueoyesj	929	8	prostate	prostate	NN
cord-000248-zueoyesj	929	9	samples	sample	NNS
cord-000248-zueoyesj	929	10	Cy5-labeled	cy5-labele	VBN
cord-000248-zueoyesj	929	11	cDNA	cdna	NN
cord-000248-zueoyesj	929	12	was	be	VBD
cord-000248-zueoyesj	929	13	prepared	prepared	JJ
cord-000248-zueoyesj	929	14	and	and	CC
cord-000248-zueoyesj	929	15	Cy3-labeled	Cy3-labeled	NNP
cord-000248-zueoyesj	929	16	cDNA	cdna	NN
cord-000248-zueoyesj	929	17	used	use	VBD
cord-000248-zueoyesj	929	18	1.5	1.5	CD
cord-000248-zueoyesj	929	19	mg	mg	NNP
cord-000248-zueoyesj	929	20	of	of	IN
cord-000248-zueoyesj	929	21	mRNA	mRNA	NNP
cord-000248-zueoyesj	929	22	common	common	JJ
cord-000248-zueoyesj	929	23	reference	reference	NN
cord-000248-zueoyesj	929	24	,	,	,
cord-000248-zueoyesj	929	25	pooled	pool	VBN
cord-000248-zueoyesj	929	26	from	from	IN
cord-000248-zueoyesj	929	27	11	11	CD
cord-000248-zueoyesj	929	28	human	human	JJ
cord-000248-zueoyesj	929	29	cell	cell	NN
cord-000248-zueoyesj	929	30	lines	line	NNS
cord-000248-zueoyesj	929	31	(	(	-LRB-
cord-000248-zueoyesj	929	32	see	see	VB
cord-000248-zueoyesj	929	33	Ref	Ref	NNP
cord-000248-zueoyesj	929	34	.	.	.
cord-000248-zueoyesj	930	1	[	[	-LRB-
cord-000248-zueoyesj	930	2	792	792	CD
cord-000248-zueoyesj	930	3	]	]	-RRB-
cord-000248-zueoyesj	930	4	)	)	-RRB-
cord-000248-zueoyesj	930	5	.	.	.
cord-000248-zueoyesj	931	1	The	the	DT
cord-000248-zueoyesj	931	2	fluorescence	fluorescence	NN
cord-000248-zueoyesj	931	3	ratios	ratio	NNS
cord-000248-zueoyesj	931	4	were	be	VBD
cord-000248-zueoyesj	931	5	subsequently	subsequently	RB
cord-000248-zueoyesj	931	6	normalized	normalize	VBN
cord-000248-zueoyesj	931	7	by	by	IN
cord-000248-zueoyesj	931	8	mean	mean	JJ
cord-000248-zueoyesj	931	9	centering	center	VBG
cord-000248-zueoyesj	931	10	genes	gene	NNS
cord-000248-zueoyesj	931	11	for	for	IN
cord-000248-zueoyesj	931	12	each	each	DT
cord-000248-zueoyesj	931	13	array	array	NN
cord-000248-zueoyesj	931	14	,	,	,
cord-000248-zueoyesj	931	15	a	a	DT
cord-000248-zueoyesj	931	16	relatively	relatively	RB
cord-000248-zueoyesj	931	17	standard	standard	JJ
cord-000248-zueoyesj	931	18	procedure	procedure	NN
cord-000248-zueoyesj	931	19	.	.	.
cord-000248-zueoyesj	932	1	In	in	IN
cord-000248-zueoyesj	932	2	addition	addition	NN
cord-000248-zueoyesj	932	3	,	,	,
cord-000248-zueoyesj	932	4	to	to	TO
cord-000248-zueoyesj	932	5	minimize	minimize	VB
cord-000248-zueoyesj	932	6	potential	potential	JJ
cord-000248-zueoyesj	932	7	print	print	NN
cord-000248-zueoyesj	932	8	run	run	VB
cord-000248-zueoyesj	932	9	specific	specific	JJ
cord-000248-zueoyesj	932	10	bias	bias	NN
cord-000248-zueoyesj	932	11	,	,	,
cord-000248-zueoyesj	932	12	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	932	13	et	et	FW
cord-000248-zueoyesj	932	14	al	al	NNP
cord-000248-zueoyesj	932	15	.	.	.
cord-000248-zueoyesj	933	1	report	report	VB
cord-000248-zueoyesj	933	2	that	that	IN
cord-000248-zueoyesj	933	3	ratios	ratio	NNS
cord-000248-zueoyesj	933	4	were	be	VBD
cord-000248-zueoyesj	933	5	then	then	RB
cord-000248-zueoyesj	933	6	mean	mean	JJ
cord-000248-zueoyesj	933	7	centered	center	VBN
cord-000248-zueoyesj	933	8	for	for	IN
cord-000248-zueoyesj	933	9	each	each	DT
cord-000248-zueoyesj	933	10	gene	gene	NN
cord-000248-zueoyesj	933	11	across	across	IN
cord-000248-zueoyesj	933	12	all	all	DT
cord-000248-zueoyesj	933	13	arrays	array	NNS
cord-000248-zueoyesj	933	14	according	accord	VBG
cord-000248-zueoyesj	933	15	to	to	IN
cord-000248-zueoyesj	933	16	Ref	Ref	NNP
cord-000248-zueoyesj	933	17	.	.	.
cord-000248-zueoyesj	934	1	[	[	-LRB-
cord-000248-zueoyesj	934	2	793	793	CD
cord-000248-zueoyesj	934	3	]	]	-RRB-
cord-000248-zueoyesj	934	4	.	.	.
cord-000248-zueoyesj	935	1	We	-PRON-	PRP
cord-000248-zueoyesj	935	2	have	have	VBP
cord-000248-zueoyesj	935	3	only	only	RB
cord-000248-zueoyesj	935	4	used	use	VBN
cord-000248-zueoyesj	935	5	the	the	DT
cord-000248-zueoyesj	935	6	genes	gene	NNS
cord-000248-zueoyesj	935	7	that	that	WDT
cord-000248-zueoyesj	935	8	the	the	DT
cord-000248-zueoyesj	935	9	authors	author	NNS
cord-000248-zueoyesj	935	10	report	report	VBP
cord-000248-zueoyesj	935	11	in	in	IN
cord-000248-zueoyesj	935	12	their	-PRON-	PRP$
cord-000248-zueoyesj	935	13	first	first	JJ
cord-000248-zueoyesj	935	14	figure	figure	NN
cord-000248-zueoyesj	935	15	,	,	,
cord-000248-zueoyesj	935	16	5,153	5,153	CD
cord-000248-zueoyesj	935	17	genes	gene	NNS
cord-000248-zueoyesj	935	18	that	that	WDT
cord-000248-zueoyesj	935	19	have	have	VBP
cord-000248-zueoyesj	935	20	been	be	VBN
cord-000248-zueoyesj	935	21	well	well	RB
cord-000248-zueoyesj	935	22	measured	measure	VBN
cord-000248-zueoyesj	935	23	and	and	CC
cord-000248-zueoyesj	935	24	have	have	VB
cord-000248-zueoyesj	935	25	significan	significan	JJ
cord-000248-zueoyesj	935	26	variation	variation	NN
cord-000248-zueoyesj	935	27	in	in	IN
cord-000248-zueoyesj	935	28	some	some	DT
cord-000248-zueoyesj	935	29	of	of	IN
cord-000248-zueoyesj	935	30	the	the	DT
cord-000248-zueoyesj	935	31	samples	sample	NNS
cord-000248-zueoyesj	935	32	.	.	.
cord-000248-zueoyesj	936	1	For	for	IN
cord-000248-zueoyesj	936	2	the	the	DT
cord-000248-zueoyesj	936	3	other	other	JJ
cord-000248-zueoyesj	936	4	details	detail	NNS
cord-000248-zueoyesj	936	5	of	of	IN
cord-000248-zueoyesj	936	6	their	-PRON-	PRP$
cord-000248-zueoyesj	936	7	matrials	matrial	NNS
cord-000248-zueoyesj	936	8	and	and	CC
cord-000248-zueoyesj	936	9	methods	method	NNS
cord-000248-zueoyesj	936	10	we	-PRON-	PRP
cord-000248-zueoyesj	936	11	refer	refer	VBP
cord-000248-zueoyesj	936	12	the	the	DT
cord-000248-zueoyesj	936	13	readers	reader	NNS
cord-000248-zueoyesj	936	14	to	to	IN
cord-000248-zueoyesj	936	15	the	the	DT
cord-000248-zueoyesj	936	16	Supporting	support	VBG
cord-000248-zueoyesj	936	17	Notes	Notes	NNPS
cord-000248-zueoyesj	936	18	and	and	CC
cord-000248-zueoyesj	936	19	the	the	DT
cord-000248-zueoyesj	936	20	Materials	Materials	NNPS
cord-000248-zueoyesj	936	21	and	and	CC
cord-000248-zueoyesj	936	22	Methods	Methods	NNPS
cord-000248-zueoyesj	936	23	section	section	NN
cord-000248-zueoyesj	936	24	of	of	IN
cord-000248-zueoyesj	936	25	their	-PRON-	PRP$
cord-000248-zueoyesj	936	26	original	original	JJ
cord-000248-zueoyesj	936	27	publication	publication	NN
cord-000248-zueoyesj	936	28	[	[	-LRB-
cord-000248-zueoyesj	936	29	44	44	CD
cord-000248-zueoyesj	936	30	]	]	-RRB-
cord-000248-zueoyesj	936	31	.	.	.
cord-000248-zueoyesj	937	1	Samples	sample	NNS
cord-000248-zueoyesj	937	2	were	be	VBD
cord-000248-zueoyesj	937	3	obtained	obtain	VBN
cord-000248-zueoyesj	937	4	from	from	IN
cord-000248-zueoyesj	937	5	nevus	nevus	NN
cord-000248-zueoyesj	937	6	volunteers	volunteer	NNS
cord-000248-zueoyesj	937	7	and	and	CC
cord-000248-zueoyesj	937	8	melanoma	melanoma	NN
cord-000248-zueoyesj	937	9	patients	patient	NNS
cord-000248-zueoyesj	937	10	and	and	CC
cord-000248-zueoyesj	937	11	only	only	RB
cord-000248-zueoyesj	937	12	those	those	DT
cord-000248-zueoyesj	937	13	samples	sample	NNS
cord-000248-zueoyesj	937	14	that	that	WDT
cord-000248-zueoyesj	937	15	have	have	VBP
cord-000248-zueoyesj	937	16	more	more	JJR
cord-000248-zueoyesj	937	17	than	than	IN
cord-000248-zueoyesj	937	18	90	90	CD
cord-000248-zueoyesj	937	19	%	%	NN
cord-000248-zueoyesj	937	20	of	of	IN
cord-000248-zueoyesj	937	21	tumor	tumor	NN
cord-000248-zueoyesj	937	22	cells	cell	NNS
cord-000248-zueoyesj	937	23	were	be	VBD
cord-000248-zueoyesj	937	24	profiled	profile	VBN
cord-000248-zueoyesj	937	25	.	.	.
cord-000248-zueoyesj	938	1	The	the	DT
cord-000248-zueoyesj	938	2	20,862	20,862	CD
cord-000248-zueoyesj	938	3	cDNAs	cDNAs	NNPS
cord-000248-zueoyesj	938	4	used	use	VBN
cord-000248-zueoyesj	938	5	(	(	-LRB-
cord-000248-zueoyesj	938	6	Research	Research	NNP
cord-000248-zueoyesj	938	7	Genetics	Genetics	NNP
cord-000248-zueoyesj	938	8	,	,	,
cord-000248-zueoyesj	938	9	Huntsville	Huntsville	NNP
cord-000248-zueoyesj	938	10	,	,	,
cord-000248-zueoyesj	938	11	AL	AL	NNP
cord-000248-zueoyesj	938	12	)	)	-RRB-
cord-000248-zueoyesj	938	13	represent	represent	VBP
cord-000248-zueoyesj	938	14	19,740	19,740	CD
cord-000248-zueoyesj	938	15	independent	independent	JJ
cord-000248-zueoyesj	938	16	loci	locus	NNS
cord-000248-zueoyesj	938	17	.	.	.
cord-000248-zueoyesj	939	1	(	(	-LRB-
cord-000248-zueoyesj	939	2	Unigene	Unigene	NNP
cord-000248-zueoyesj	939	3	build	build	VB
cord-000248-zueoyesj	939	4	166).median	166).median	CD
cord-000248-zueoyesj	939	5	of	of	IN
cord-000248-zueoyesj	939	6	ratio	ratio	NN
cord-000248-zueoyesj	939	7	values	value	NNS
cord-000248-zueoyesj	939	8	from	from	IN
cord-000248-zueoyesj	939	9	the	the	DT
cord-000248-zueoyesj	939	10	experiment	experiment	NN
cord-000248-zueoyesj	939	11	were	be	VBD
cord-000248-zueoyesj	939	12	subjected	subject	VBN
cord-000248-zueoyesj	939	13	to	to	IN
cord-000248-zueoyesj	939	14	linear	linear	JJ
cord-000248-zueoyesj	939	15	normalization	normalization	NN
cord-000248-zueoyesj	939	16	in	in	IN
cord-000248-zueoyesj	939	17	nomad	nomad	NN
cord-000248-zueoyesj	939	18	(	(	-LRB-
cord-000248-zueoyesj	939	19	which	which	WDT
cord-000248-zueoyesj	939	20	can	can	MD
cord-000248-zueoyesj	939	21	be	be	VB
cord-000248-zueoyesj	939	22	accessed	access	VBN
cord-000248-zueoyesj	939	23	at	at	IN
cord-000248-zueoyesj	939	24	http://derisilab.ucsf.edu	http://derisilab.ucsf.edu	NNP
cord-000248-zueoyesj	939	25	)	)	-RRB-
cord-000248-zueoyesj	939	26	,	,	,
cord-000248-zueoyesj	939	27	log	log	NN
cord-000248-zueoyesj	939	28	-	-	HYPH
cord-000248-zueoyesj	939	29	transformed	transform	VBN
cord-000248-zueoyesj	939	30	(	(	-LRB-
cord-000248-zueoyesj	939	31	base	base	NN
cord-000248-zueoyesj	939	32	2	2	CD
cord-000248-zueoyesj	939	33	)	)	-RRB-
cord-000248-zueoyesj	939	34	,	,	,
cord-000248-zueoyesj	939	35	and	and	CC
cord-000248-zueoyesj	939	36	filtered	filter	VBN
cord-000248-zueoyesj	939	37	for	for	IN
cord-000248-zueoyesj	939	38	genes	gene	NNS
cord-000248-zueoyesj	939	39	where	where	WRB
cord-000248-zueoyesj	939	40	data	datum	NNS
cord-000248-zueoyesj	939	41	were	be	VBD
cord-000248-zueoyesj	939	42	present	present	JJ
cord-000248-zueoyesj	939	43	in	in	IN
cord-000248-zueoyesj	939	44	80	80	CD
cord-000248-zueoyesj	939	45	%	%	NN
cord-000248-zueoyesj	939	46	of	of	IN
cord-000248-zueoyesj	939	47	experiments	experiment	NNS
cord-000248-zueoyesj	939	48	,	,	,
cord-000248-zueoyesj	939	49	and	and	CC
cord-000248-zueoyesj	939	50	where	where	WRB
cord-000248-zueoyesj	939	51	the	the	DT
cord-000248-zueoyesj	939	52	absolute	absolute	JJ
cord-000248-zueoyesj	939	53	value	value	NN
cord-000248-zueoyesj	939	54	of	of	IN
cord-000248-zueoyesj	939	55	at	at	RB
cord-000248-zueoyesj	939	56	least	least	RBS
cord-000248-zueoyesj	939	57	one	one	CD
cord-000248-zueoyesj	939	58	measurement	measurement	NN
cord-000248-zueoyesj	939	59	was	be	VBD
cord-000248-zueoyesj	939	60	.1	.1	.
cord-000248-zueoyesj	939	61	.	.	.
cord-000248-zueoyesj	940	1	In	in	IN
cord-000248-zueoyesj	940	2	this	this	DT
cord-000248-zueoyesj	940	3	dataset	dataset	NN
cord-000248-zueoyesj	940	4	,	,	,
cord-000248-zueoyesj	940	5	samples	sample	NNS
cord-000248-zueoyesj	940	6	have	have	VBP
cord-000248-zueoyesj	940	7	information	information	NN
cord-000248-zueoyesj	940	8	of	of	IN
cord-000248-zueoyesj	940	9	15,488	15,488	CD
cord-000248-zueoyesj	940	10	spots	spot	NNS
cord-000248-zueoyesj	940	11	per	per	IN
cord-000248-zueoyesj	940	12	array	array	NN
cord-000248-zueoyesj	940	13	,	,	,
cord-000248-zueoyesj	940	14	with	with	IN
cord-000248-zueoyesj	940	15	a	a	DT
cord-000248-zueoyesj	940	16	total	total	NN
cord-000248-zueoyesj	940	17	of	of	IN
cord-000248-zueoyesj	940	18	7,700	7,700	CD
cord-000248-zueoyesj	940	19	unique	unique	JJ
cord-000248-zueoyesj	940	20	cDNAs	cdna	NNS
cord-000248-zueoyesj	940	21	represented	represent	VBN
cord-000248-zueoyesj	940	22	.	.	.
cord-000248-zueoyesj	941	1	The	the	DT
cord-000248-zueoyesj	941	2	samples	sample	NNS
cord-000248-zueoyesj	941	3	were	be	VBD
cord-000248-zueoyesj	941	4	obtained	obtain	VBN
cord-000248-zueoyesj	941	5	from	from	IN
cord-000248-zueoyesj	941	6	frozen	frozen	JJ
cord-000248-zueoyesj	941	7	tissue	tissue	NN
cord-000248-zueoyesj	941	8	blocks	block	NNS
cord-000248-zueoyesj	941	9	from	from	IN
cord-000248-zueoyesj	941	10	29	29	CD
cord-000248-zueoyesj	941	11	radical	radical	JJ
cord-000248-zueoyesj	941	12	prostatectomies	prostatectomy	NNS
cord-000248-zueoyesj	941	13	accessioned	accession	VBN
cord-000248-zueoyesj	941	14	and	and	CC
cord-000248-zueoyesj	941	15	selected	select	VBN
cord-000248-zueoyesj	941	16	to	to	TO
cord-000248-zueoyesj	941	17	represent	represent	VB
cord-000248-zueoyesj	941	18	Gleason	Gleason	NNP
cord-000248-zueoyesj	941	19	grades	grade	NNS
cord-000248-zueoyesj	941	20	3	3	CD
cord-000248-zueoyesj	941	21	,	,	,
cord-000248-zueoyesj	941	22	4	4	CD
cord-000248-zueoyesj	941	23	,	,	,
cord-000248-zueoyesj	941	24	and	and	CC
cord-000248-zueoyesj	941	25	5	5	CD
cord-000248-zueoyesj	941	26	.	.	.
cord-000248-zueoyesj	942	1	The	the	DT
cord-000248-zueoyesj	942	2	samples	sample	NNS
cord-000248-zueoyesj	942	3	are	be	VBP
cord-000248-zueoyesj	942	4	'	'	''
cord-000248-zueoyesj	942	5	'	'	''
cord-000248-zueoyesj	942	6	treatment	treatment	NN
cord-000248-zueoyesj	942	7	naïve	naïve	NNP
cord-000248-zueoyesj	942	8	'	'	''
cord-000248-zueoyesj	942	9	'	'	''
cord-000248-zueoyesj	942	10	,	,	,
cord-000248-zueoyesj	942	11	meaning	mean	VBG
cord-000248-zueoyesj	942	12	that	that	IN
cord-000248-zueoyesj	942	13	they	-PRON-	PRP
cord-000248-zueoyesj	942	14	were	be	VBD
cord-000248-zueoyesj	942	15	also	also	RB
cord-000248-zueoyesj	942	16	selected	select	VBN
cord-000248-zueoyesj	942	17	such	such	JJ
cord-000248-zueoyesj	942	18	that	that	IN
cord-000248-zueoyesj	942	19	their	-PRON-	PRP$
cord-000248-zueoyesj	942	20	gene	gene	NN
cord-000248-zueoyesj	942	21	expression	expression	NN
cord-000248-zueoyesj	942	22	profile	profile	NN
cord-000248-zueoyesj	942	23	is	be	VBZ
cord-000248-zueoyesj	942	24	also	also	RB
cord-000248-zueoyesj	942	25	and	and	CC
cord-000248-zueoyesj	942	26	the	the	DT
cord-000248-zueoyesj	942	27	absence	absence	NN
cord-000248-zueoyesj	942	28	of	of	IN
cord-000248-zueoyesj	942	29	any	any	DT
cord-000248-zueoyesj	942	30	bias	bias	NN
cord-000248-zueoyesj	942	31	that	that	IN
cord-000248-zueoyesj	942	32	the	the	DT
cord-000248-zueoyesj	942	33	treatment	treatment	NN
cord-000248-zueoyesj	942	34	before	before	IN
cord-000248-zueoyesj	942	35	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	942	36	.	.	.
cord-000248-zueoyesj	943	1	The	the	DT
cord-000248-zueoyesj	943	2	frozen	frozen	JJ
cord-000248-zueoyesj	943	3	sections	section	NNS
cord-000248-zueoyesj	943	4	(	(	-LRB-
cord-000248-zueoyesj	943	5	8	8	CD
cord-000248-zueoyesj	943	6	mm	mm	NN
cord-000248-zueoyesj	943	7	)	)	-RRB-
cord-000248-zueoyesj	943	8	were	be	VBD
cord-000248-zueoyesj	943	9	cut	cut	VBN
cord-000248-zueoyesj	943	10	from	from	IN
cord-000248-zueoyesj	943	11	optimal	optimal	JJ
cord-000248-zueoyesj	943	12	cutting	cut	VBG
cord-000248-zueoyesj	943	13	temperature	temperature	NN
cord-000248-zueoyesj	943	14	medium	medium	NN
cord-000248-zueoyesj	943	15	blocks	block	NNS
cord-000248-zueoyesj	943	16	and	and	CC
cord-000248-zueoyesj	943	17	immediately	immediately	RB
cord-000248-zueoyesj	943	18	fixed	fix	VBN
cord-000248-zueoyesj	943	19	in	in	IN
cord-000248-zueoyesj	943	20	cold	cold	JJ
cord-000248-zueoyesj	943	21	95	95	CD
cord-000248-zueoyesj	943	22	%	%	NN
cord-000248-zueoyesj	943	23	ethanol	ethanol	NN
cord-000248-zueoyesj	943	24	.	.	.
cord-000248-zueoyesj	944	1	Around	around	IN
cord-000248-zueoyesj	944	2	5,000	5,000	CD
cord-000248-zueoyesj	944	3	epithelial	epithelial	JJ
cord-000248-zueoyesj	944	4	cells	cell	NNS
cord-000248-zueoyesj	944	5	from	from	IN
cord-000248-zueoyesj	944	6	both	both	CC
cord-000248-zueoyesj	944	7	histologically	histologically	RB
cord-000248-zueoyesj	944	8	benign	benign	JJ
cord-000248-zueoyesj	944	9	glands	gland	NNS
cord-000248-zueoyesj	944	10	and	and	CC
cord-000248-zueoyesj	944	11	cancer	cancer	NN
cord-000248-zueoyesj	944	12	glands	gland	NNS
cord-000248-zueoyesj	944	13	were	be	VBD
cord-000248-zueoyesj	944	14	separately	separately	RB
cord-000248-zueoyesj	944	15	laser	laser	NN
cord-000248-zueoyesj	944	16	-	-	HYPH
cord-000248-zueoyesj	944	17	capture	capture	NN
cord-000248-zueoyesj	944	18	microdissected	microdissected	JJ
cord-000248-zueoyesj	944	19	(	(	-LRB-
cord-000248-zueoyesj	944	20	LCM	LCM	NNP
cord-000248-zueoyesj	944	21	)	)	-RRB-
cord-000248-zueoyesj	944	22	.	.	.
cord-000248-zueoyesj	945	1	The	the	DT
cord-000248-zueoyesj	945	2	authors	author	NNS
cord-000248-zueoyesj	945	3	of	of	IN
cord-000248-zueoyesj	945	4	the	the	DT
cord-000248-zueoyesj	945	5	study	study	NN
cord-000248-zueoyesj	945	6	have	have	VBP
cord-000248-zueoyesj	945	7	also	also	RB
cord-000248-zueoyesj	945	8	been	be	VBN
cord-000248-zueoyesj	945	9	very	very	RB
cord-000248-zueoyesj	945	10	careful	careful	JJ
cord-000248-zueoyesj	945	11	to	to	TO
cord-000248-zueoyesj	945	12	include	include	VB
cord-000248-zueoyesj	945	13	only	only	RB
cord-000248-zueoyesj	945	14	one	one	CD
cord-000248-zueoyesj	945	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	945	16	pattern	pattern	NN
cord-000248-zueoyesj	945	17	in	in	IN
cord-000248-zueoyesj	945	18	each	each	DT
cord-000248-zueoyesj	945	19	laser	laser	NN
cord-000248-zueoyesj	945	20	-	-	HYPH
cord-000248-zueoyesj	945	21	captured	capture	VBN
cord-000248-zueoyesj	945	22	cancer	cancer	NN
cord-000248-zueoyesj	945	23	sample	sample	NN
cord-000248-zueoyesj	945	24	,	,	,
cord-000248-zueoyesj	945	25	following	follow	VBG
cord-000248-zueoyesj	945	26	a	a	DT
cord-000248-zueoyesj	945	27	process	process	NN
cord-000248-zueoyesj	945	28	in	in	IN
cord-000248-zueoyesj	945	29	which	which	WDT
cord-000248-zueoyesj	945	30	the	the	DT
cord-000248-zueoyesj	945	31	patterns	pattern	NNS
cord-000248-zueoyesj	945	32	were	be	VBD
cord-000248-zueoyesj	945	33	assessed	assess	VBN
cord-000248-zueoyesj	945	34	independently	independently	RB
cord-000248-zueoyesj	945	35	by	by	IN
cord-000248-zueoyesj	945	36	two	two	CD
cord-000248-zueoyesj	945	37	investigators	investigator	NNS
cord-000248-zueoyesj	945	38	.	.	.
cord-000248-zueoyesj	946	1	The	the	DT
cord-000248-zueoyesj	946	2	matched	match	VBN
cord-000248-zueoyesj	946	3	benign	benign	JJ
cord-000248-zueoyesj	946	4	epithelium	epithelium	NN
cord-000248-zueoyesj	946	5	was	be	VBD
cord-000248-zueoyesj	946	6	captured	capture	VBN
cord-000248-zueoyesj	946	7	for	for	IN
cord-000248-zueoyesj	946	8	each	each	DT
cord-000248-zueoyesj	946	9	cancer	cancer	NN
cord-000248-zueoyesj	946	10	sample	sample	NN
cord-000248-zueoyesj	946	11	for	for	IN
cord-000248-zueoyesj	946	12	a	a	DT
cord-000248-zueoyesj	946	13	total	total	NN
cord-000248-zueoyesj	946	14	of	of	IN
cord-000248-zueoyesj	946	15	121	121	CD
cord-000248-zueoyesj	946	16	samples	sample	NNS
cord-000248-zueoyesj	946	17	.	.	.
cord-000248-zueoyesj	947	1	An	an	DT
cord-000248-zueoyesj	947	2	important	important	JJ
cord-000248-zueoyesj	947	3	characteristic	characteristic	NN
cord-000248-zueoyesj	947	4	of	of	IN
cord-000248-zueoyesj	947	5	this	this	DT
cord-000248-zueoyesj	947	6	dataset	dataset	NN
cord-000248-zueoyesj	947	7	is	be	VBZ
cord-000248-zueoyesj	947	8	the	the	DT
cord-000248-zueoyesj	947	9	normalization	normalization	NN
cord-000248-zueoyesj	947	10	procedure	procedure	NN
cord-000248-zueoyesj	947	11	.	.	.
cord-000248-zueoyesj	948	1	For	for	IN
cord-000248-zueoyesj	948	2	each	each	DT
cord-000248-zueoyesj	948	3	spot	spot	NN
cord-000248-zueoyesj	948	4	and	and	CC
cord-000248-zueoyesj	948	5	in	in	IN
cord-000248-zueoyesj	948	6	each	each	DT
cord-000248-zueoyesj	948	7	channel	channel	NN
cord-000248-zueoyesj	948	8	(	(	-LRB-
cord-000248-zueoyesj	948	9	Cy3	Cy3	NNP
cord-000248-zueoyesj	948	10	and	and	CC
cord-000248-zueoyesj	948	11	Cy5	cy5	CD
cord-000248-zueoyesj	948	12	)	)	-RRB-
cord-000248-zueoyesj	948	13	,	,	,
cord-000248-zueoyesj	948	14	True	true	JJ
cord-000248-zueoyesj	948	15	et	et	NNP
cord-000248-zueoyesj	948	16	al	al	NNP
cord-000248-zueoyesj	948	17	.	.	NNP
cord-000248-zueoyesj	948	18	substracted	substracte	VBD
cord-000248-zueoyesj	948	19	the	the	DT
cord-000248-zueoyesj	948	20	median	median	JJ
cord-000248-zueoyesj	948	21	background	background	NN
cord-000248-zueoyesj	948	22	intensity	intensity	NN
cord-000248-zueoyesj	948	23	from	from	IN
cord-000248-zueoyesj	948	24	the	the	DT
cord-000248-zueoyesj	948	25	median	median	JJ
cord-000248-zueoyesj	948	26	foreground	foreground	NN
cord-000248-zueoyesj	948	27	intensity	intensity	NN
cord-000248-zueoyesj	948	28	,	,	,
cord-000248-zueoyesj	948	29	and	and	CC
cord-000248-zueoyesj	948	30	subsequently	subsequently	RB
cord-000248-zueoyesj	948	31	the	the	DT
cord-000248-zueoyesj	948	32	log	log	NN
cord-000248-zueoyesj	948	33	ratios	ratio	NNS
cord-000248-zueoyesj	948	34	of	of	IN
cord-000248-zueoyesj	948	35	cancer	cancer	NN
cord-000248-zueoyesj	948	36	expression	expression	NN
cord-000248-zueoyesj	948	37	to	to	IN
cord-000248-zueoyesj	948	38	benign	benign	JJ
cord-000248-zueoyesj	948	39	expression	expression	NN
cord-000248-zueoyesj	948	40	were	be	VBD
cord-000248-zueoyesj	948	41	computed	compute	VBN
cord-000248-zueoyesj	948	42	.	.	.
cord-000248-zueoyesj	949	1	These	these	DT
cord-000248-zueoyesj	949	2	ratios	ratio	NNS
cord-000248-zueoyesj	949	3	were	be	VBD
cord-000248-zueoyesj	949	4	obtained	obtain	VBN
cord-000248-zueoyesj	949	5	by	by	IN
cord-000248-zueoyesj	949	6	first	first	RB
cord-000248-zueoyesj	949	7	dividing	divide	VBG
cord-000248-zueoyesj	949	8	the	the	DT
cord-000248-zueoyesj	949	9	background	background	NN
cord-000248-zueoyesj	949	10	-	-	HYPH
cord-000248-zueoyesj	949	11	subtracted	subtract	VBN
cord-000248-zueoyesj	949	12	intensities	intensity	NNS
cord-000248-zueoyesj	949	13	(	(	-LRB-
cord-000248-zueoyesj	949	14	Prostate	Prostate	NNP
cord-000248-zueoyesj	949	15	Cancer	Cancer	NNP
cord-000248-zueoyesj	949	16	/	/	,
cord-000248-zueoyesj	949	17	Benign	benign	JJ
cord-000248-zueoyesj	949	18	)	)	-RRB-
cord-000248-zueoyesj	949	19	and	and	CC
cord-000248-zueoyesj	949	20	then	then	RB
cord-000248-zueoyesj	949	21	taking	take	VBG
cord-000248-zueoyesj	949	22	the	the	DT
cord-000248-zueoyesj	949	23	logarithm	logarithm	NN
cord-000248-zueoyesj	949	24	base	base	NN
cord-000248-zueoyesj	949	25	2	2	CD
cord-000248-zueoyesj	949	26	.	.	.
cord-000248-zueoyesj	950	1	In	in	IN
cord-000248-zueoyesj	950	2	the	the	DT
cord-000248-zueoyesj	950	3	case	case	NN
cord-000248-zueoyesj	950	4	that	that	IN
cord-000248-zueoyesj	950	5	the	the	DT
cord-000248-zueoyesj	950	6	median	median	JJ
cord-000248-zueoyesj	950	7	background	background	NN
cord-000248-zueoyesj	950	8	intensity	intensity	NN
cord-000248-zueoyesj	950	9	was	be	VBD
cord-000248-zueoyesj	950	10	greater	great	JJR
cord-000248-zueoyesj	950	11	than	than	IN
cord-000248-zueoyesj	950	12	the	the	DT
cord-000248-zueoyesj	950	13	median	median	JJ
cord-000248-zueoyesj	950	14	foreground	foreground	NN
cord-000248-zueoyesj	950	15	intensity	intensity	NN
cord-000248-zueoyesj	950	16	,	,	,
cord-000248-zueoyesj	950	17	the	the	DT
cord-000248-zueoyesj	950	18	spot	spot	NN
cord-000248-zueoyesj	950	19	was	be	VBD
cord-000248-zueoyesj	950	20	considered	consider	VBN
cord-000248-zueoyesj	950	21	missing	miss	VBG
cord-000248-zueoyesj	950	22	.	.	.
cord-000248-zueoyesj	951	1	We	-PRON-	PRP
cord-000248-zueoyesj	951	2	refer	refer	VBP
cord-000248-zueoyesj	951	3	to	to	IN
cord-000248-zueoyesj	951	4	the	the	DT
cord-000248-zueoyesj	951	5	original	original	JJ
cord-000248-zueoyesj	951	6	publication	publication	NN
cord-000248-zueoyesj	951	7	for	for	IN
cord-000248-zueoyesj	951	8	the	the	DT
cord-000248-zueoyesj	951	9	other	other	JJ
cord-000248-zueoyesj	951	10	aspects	aspect	NNS
cord-000248-zueoyesj	951	11	of	of	IN
cord-000248-zueoyesj	951	12	imputation	imputation	NN
cord-000248-zueoyesj	951	13	,	,	,
cord-000248-zueoyesj	951	14	spot	spot	NN
cord-000248-zueoyesj	951	15	quality	quality	NN
cord-000248-zueoyesj	951	16	and	and	CC
cord-000248-zueoyesj	951	17	filtering	filtering	NN
cord-000248-zueoyesj	951	18	,	,	,
cord-000248-zueoyesj	951	19	but	but	CC
cord-000248-zueoyesj	951	20	,	,	,
cord-000248-zueoyesj	951	21	like	like	UH
cord-000248-zueoyesj	951	22	in	in	IN
cord-000248-zueoyesj	951	23	Lapointe	Lapointe	NNP
cord-000248-zueoyesj	951	24	et	et	FW
cord-000248-zueoyesj	951	25	al	al	NNP
cord-000248-zueoyesj	951	26	's	's	POS
cord-000248-zueoyesj	951	27	study	study	NN
cord-000248-zueoyesj	951	28	,	,	,
cord-000248-zueoyesj	951	29	they	-PRON-	PRP
cord-000248-zueoyesj	951	30	also	also	RB
cord-000248-zueoyesj	951	31	filter	filter	VBP
cord-000248-zueoyesj	951	32	to	to	TO
cord-000248-zueoyesj	951	33	keep	keep	VB
cord-000248-zueoyesj	951	34	informative	informative	JJ
cord-000248-zueoyesj	951	35	(	(	-LRB-
cord-000248-zueoyesj	951	36	expression	expression	NN
cord-000248-zueoyesj	951	37	ratios	ratio	NNS
cord-000248-zueoyesj	951	38	of	of	IN
cord-000248-zueoyesj	951	39	benign	benign	JJ
cord-000248-zueoyesj	951	40	versus	versus	IN
cord-000248-zueoyesj	951	41	cancer	cancer	NN
cord-000248-zueoyesj	951	42	should	should	MD
cord-000248-zueoyesj	951	43	at	at	IN
cord-000248-zueoyesj	951	44	least	least	JJS
cord-000248-zueoyesj	951	45	be	be	VB
cord-000248-zueoyesj	951	46	1.5-fold	1.5-fold	CD
cord-000248-zueoyesj	951	47	or	or	CC
cord-000248-zueoyesj	951	48	greater	great	JJR
cord-000248-zueoyesj	951	49	in	in	IN
cord-000248-zueoyesj	951	50	at	at	RB
cord-000248-zueoyesj	951	51	least	least	JJS
cord-000248-zueoyesj	951	52	half	half	NN
cord-000248-zueoyesj	951	53	of	of	IN
cord-000248-zueoyesj	951	54	one	one	CD
cord-000248-zueoyesj	951	55	of	of	IN
cord-000248-zueoyesj	951	56	the	the	DT
cord-000248-zueoyesj	951	57	Gleason	Gleason	NNP
cord-000248-zueoyesj	951	58	groups	group	NNS
cord-000248-zueoyesj	951	59	as	as	IN
cord-000248-zueoyesj	951	60	one	one	CD
cord-000248-zueoyesj	951	61	of	of	IN
cord-000248-zueoyesj	951	62	the	the	DT
cord-000248-zueoyesj	951	63	selection	selection	NN
cord-000248-zueoyesj	951	64	criteria	criterion	NNS
cord-000248-zueoyesj	951	65	)	)	-RRB-
cord-000248-zueoyesj	951	66	.	.	.
cord-000248-zueoyesj	952	1	Shannon	Shannon	NNP
cord-000248-zueoyesj	952	2	Entropy	Entropy	NNP
cord-000248-zueoyesj	952	3	.	.	.
cord-000248-zueoyesj	953	1	In	in	IN
cord-000248-zueoyesj	953	2	many	many	JJ
cord-000248-zueoyesj	953	3	circumstances	circumstance	NNS
cord-000248-zueoyesj	953	4	,	,	,
cord-000248-zueoyesj	953	5	experimental	experimental	JJ
cord-000248-zueoyesj	953	6	measurements	measurement	NNS
cord-000248-zueoyesj	953	7	are	be	VBP
cord-000248-zueoyesj	953	8	associated	associate	VBN
cord-000248-zueoyesj	953	9	with	with	IN
cord-000248-zueoyesj	953	10	the	the	DT
cord-000248-zueoyesj	953	11	accumulation	accumulation	NN
cord-000248-zueoyesj	953	12	of	of	IN
cord-000248-zueoyesj	953	13	individual	individual	JJ
cord-000248-zueoyesj	953	14	results	result	NNS
cord-000248-zueoyesj	953	15	which	which	WDT
cord-000248-zueoyesj	953	16	,	,	,
cord-000248-zueoyesj	953	17	ultimately	ultimately	RB
cord-000248-zueoyesj	953	18	,	,	,
cord-000248-zueoyesj	953	19	qualitatively	qualitatively	RB
cord-000248-zueoyesj	953	20	and	and	CC
cord-000248-zueoyesj	953	21	quantitatively	quantitatively	RB
cord-000248-zueoyesj	953	22	characterized	characterize	VBN
cord-000248-zueoyesj	953	23	our	-PRON-	PRP$
cord-000248-zueoyesj	953	24	experimental	experimental	JJ
cord-000248-zueoyesj	953	25	observations	observation	NNS
cord-000248-zueoyesj	953	26	.	.	.
cord-000248-zueoyesj	954	1	The	the	DT
cord-000248-zueoyesj	954	2	presence	presence	NN
cord-000248-zueoyesj	954	3	(	(	-LRB-
cord-000248-zueoyesj	954	4	or	or	CC
cord-000248-zueoyesj	954	5	absence	absence	NN
cord-000248-zueoyesj	954	6	)	)	-RRB-
cord-000248-zueoyesj	954	7	of	of	IN
cord-000248-zueoyesj	954	8	a	a	DT
cord-000248-zueoyesj	954	9	particular	particular	JJ
cord-000248-zueoyesj	954	10	result	result	NN
cord-000248-zueoyesj	954	11	of	of	IN
cord-000248-zueoyesj	954	12	an	an	DT
cord-000248-zueoyesj	954	13	individual	individual	JJ
cord-000248-zueoyesj	954	14	experimental	experimental	JJ
cord-000248-zueoyesj	954	15	measure	measure	NN
cord-000248-zueoyesj	954	16	is	be	VBZ
cord-000248-zueoyesj	954	17	called	call	VBN
cord-000248-zueoyesj	954	18	an	an	DT
cord-000248-zueoyesj	954	19	event	event	NN
cord-000248-zueoyesj	954	20	.	.	.
cord-000248-zueoyesj	955	1	An	an	DT
cord-000248-zueoyesj	955	2	event	event	NN
cord-000248-zueoyesj	955	3	which	which	WDT
cord-000248-zueoyesj	955	4	can	can	MD
cord-000248-zueoyesj	955	5	take	take	VB
cord-000248-zueoyesj	955	6	one	one	CD
cord-000248-zueoyesj	955	7	of	of	IN
cord-000248-zueoyesj	955	8	several	several	JJ
cord-000248-zueoyesj	955	9	possible	possible	JJ
cord-000248-zueoyesj	955	10	values	value	NNS
cord-000248-zueoyesj	955	11	is	be	VBZ
cord-000248-zueoyesj	955	12	called	call	VBN
cord-000248-zueoyesj	955	13	a	a	DT
cord-000248-zueoyesj	955	14	random	random	JJ
cord-000248-zueoyesj	955	15	variable	variable	NN
cord-000248-zueoyesj	955	16	.	.	.
cord-000248-zueoyesj	956	1	Analogously	analogously	RB
cord-000248-zueoyesj	956	2	,	,	,
cord-000248-zueoyesj	956	3	a	a	DT
cord-000248-zueoyesj	956	4	random	random	JJ
cord-000248-zueoyesj	956	5	event	event	NN
cord-000248-zueoyesj	956	6	is	be	VBZ
cord-000248-zueoyesj	956	7	an	an	DT
cord-000248-zueoyesj	956	8	event	event	NN
cord-000248-zueoyesj	956	9	that	that	WDT
cord-000248-zueoyesj	956	10	can	can	MD
cord-000248-zueoyesj	956	11	either	either	CC
cord-000248-zueoyesj	956	12	fail	fail	VB
cord-000248-zueoyesj	956	13	to	to	TO
cord-000248-zueoyesj	956	14	happen	happen	VB
cord-000248-zueoyesj	956	15	,	,	,
cord-000248-zueoyesj	956	16	or	or	CC
cord-000248-zueoyesj	956	17	happens	happen	VBZ
cord-000248-zueoyesj	956	18	,	,	,
cord-000248-zueoyesj	956	19	as	as	IN
cord-000248-zueoyesj	956	20	a	a	DT
cord-000248-zueoyesj	956	21	result	result	NN
cord-000248-zueoyesj	956	22	of	of	IN
cord-000248-zueoyesj	956	23	an	an	DT
cord-000248-zueoyesj	956	24	experiment	experiment	NN
cord-000248-zueoyesj	956	25	.	.	.
cord-000248-zueoyesj	957	1	An	an	DT
cord-000248-zueoyesj	957	2	event	event	NN
cord-000248-zueoyesj	957	3	is	be	VBZ
cord-000248-zueoyesj	957	4	certain	certain	JJ
cord-000248-zueoyesj	957	5	if	if	IN
cord-000248-zueoyesj	957	6	it	-PRON-	PRP
cord-000248-zueoyesj	957	7	can	can	MD
cord-000248-zueoyesj	957	8	not	not	RB
cord-000248-zueoyesj	957	9	fail	fail	VB
cord-000248-zueoyesj	957	10	to	to	TO
cord-000248-zueoyesj	957	11	happen	happen	VB
cord-000248-zueoyesj	957	12	and	and	CC
cord-000248-zueoyesj	957	13	it	-PRON-	PRP
cord-000248-zueoyesj	957	14	is	be	VBZ
cord-000248-zueoyesj	957	15	said	say	VBN
cord-000248-zueoyesj	957	16	to	to	TO
cord-000248-zueoyesj	957	17	be	be	VB
cord-000248-zueoyesj	957	18	impossible	impossible	JJ
cord-000248-zueoyesj	957	19	if	if	IN
cord-000248-zueoyesj	957	20	it	-PRON-	PRP
cord-000248-zueoyesj	957	21	can	can	MD
cord-000248-zueoyesj	957	22	never	never	RB
cord-000248-zueoyesj	957	23	happen	happen	VB
cord-000248-zueoyesj	957	24	.	.	.
cord-000248-zueoyesj	958	1	Following	follow	VBG
cord-000248-zueoyesj	958	2	Andreyev	Andreyev	NNP
cord-000248-zueoyesj	958	3	[	[	-LRB-
cord-000248-zueoyesj	958	4	794	794	CD
cord-000248-zueoyesj	958	5	]	]	-RRB-
cord-000248-zueoyesj	958	6	,	,	,
cord-000248-zueoyesj	958	7	we	-PRON-	PRP
cord-000248-zueoyesj	958	8	will	will	MD
cord-000248-zueoyesj	958	9	define	define	VB
cord-000248-zueoyesj	958	10	the	the	DT
cord-000248-zueoyesj	958	11	probability	probability	NN
cord-000248-zueoyesj	958	12	p(x	p(x	NNP
cord-000248-zueoyesj	958	13	)	)	-RRB-
cord-000248-zueoyesj	958	14	of	of	IN
cord-000248-zueoyesj	958	15	an	an	DT
cord-000248-zueoyesj	958	16	event	event	NN
cord-000248-zueoyesj	959	1	x	x	LS
cord-000248-zueoyesj	959	2	,	,	,
cord-000248-zueoyesj	959	3	as	as	IN
cord-000248-zueoyesj	959	4	the	the	DT
cord-000248-zueoyesj	959	5	theoretical	theoretical	JJ
cord-000248-zueoyesj	959	6	frequency	frequency	NN
cord-000248-zueoyesj	959	7	of	of	IN
cord-000248-zueoyesj	959	8	the	the	DT
cord-000248-zueoyesj	959	9	event	event	NN
cord-000248-zueoyesj	959	10	x	x	SYM
cord-000248-zueoyesj	959	11	about	about	IN
cord-000248-zueoyesj	959	12	which	which	WDT
cord-000248-zueoyesj	959	13	the	the	DT
cord-000248-zueoyesj	959	14	actual	actual	JJ
cord-000248-zueoyesj	959	15	frequency	frequency	NN
cord-000248-zueoyesj	959	16	occurrence	occurrence	NN
cord-000248-zueoyesj	959	17	of	of	IN
cord-000248-zueoyesj	959	18	the	the	DT
cord-000248-zueoyesj	959	19	event	event	NN
cord-000248-zueoyesj	959	20	shows	show	VBZ
cord-000248-zueoyesj	959	21	a	a	DT
cord-000248-zueoyesj	959	22	tendency	tendency	NN
cord-000248-zueoyesj	959	23	to	to	TO
cord-000248-zueoyesj	959	24	fluctuate	fluctuate	VB
cord-000248-zueoyesj	959	25	as	as	IN
cord-000248-zueoyesj	959	26	the	the	DT
cord-000248-zueoyesj	959	27	experiment	experiment	NN
cord-000248-zueoyesj	959	28	is	be	VBZ
cord-000248-zueoyesj	959	29	repeated	repeat	VBN
cord-000248-zueoyesj	959	30	many	many	JJ
cord-000248-zueoyesj	959	31	times	time	NNS
cord-000248-zueoyesj	959	32	.	.	.
cord-000248-zueoyesj	960	1	The	the	DT
cord-000248-zueoyesj	960	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	960	3	information	information	NN
cord-000248-zueoyesj	960	4	content	content	NN
cord-000248-zueoyesj	960	5	of	of	IN
cord-000248-zueoyesj	960	6	an	an	DT
cord-000248-zueoyesj	960	7	event	event	NN
cord-000248-zueoyesj	960	8	x	x	NN
cord-000248-zueoyesj	960	9	(	(	-LRB-
cord-000248-zueoyesj	960	10	or	or	CC
cord-000248-zueoyesj	960	11	the	the	DT
cord-000248-zueoyesj	960	12	surprisal	surprisal	NN
cord-000248-zueoyesj	960	13	of	of	IN
cord-000248-zueoyesj	960	14	an	an	DT
cord-000248-zueoyesj	960	15	event	event	NN
cord-000248-zueoyesj	961	1	x	x	LS
cord-000248-zueoyesj	961	2	,	,	,
cord-000248-zueoyesj	961	3	[	[	-LRB-
cord-000248-zueoyesj	961	4	795	795	CD
cord-000248-zueoyesj	961	5	]	]	-RRB-
cord-000248-zueoyesj	961	6	)	)	-RRB-
cord-000248-zueoyesj	961	7	,	,	,
cord-000248-zueoyesj	961	8	is	be	VBZ
cord-000248-zueoyesj	961	9	defined	define	VBN
cord-000248-zueoyesj	961	10	as	as	IN
cord-000248-zueoyesj	961	11	h(x)~log	h(x)~log	NNP
cord-000248-zueoyesj	961	12	2	2	CD
cord-000248-zueoyesj	961	13	1	1	CD
cord-000248-zueoyesj	961	14	p(x	p(x	NNP
cord-000248-zueoyesj	961	15	)	)	-RRB-
cord-000248-zueoyesj	962	1	Following	follow	VBG
cord-000248-zueoyesj	962	2	McKay	McKay	NNP
cord-000248-zueoyesj	962	3	[	[	-LRB-
cord-000248-zueoyesj	962	4	796	796	CD
cord-000248-zueoyesj	962	5	]	]	-RRB-
cord-000248-zueoyesj	962	6	,	,	.
cord-000248-zueoyesj	963	1	an	an	DT
cord-000248-zueoyesj	963	2	ensamble	ensamble	NN
cord-000248-zueoyesj	963	3	X	X	NNP
cord-000248-zueoyesj	963	4	is	be	VBZ
cord-000248-zueoyesj	963	5	a	a	DT
cord-000248-zueoyesj	963	6	triple	triple	JJ
cord-000248-zueoyesj	963	7	(	(	-LRB-
cord-000248-zueoyesj	963	8	x	x	SYM
cord-000248-zueoyesj	963	9	,	,	,
cord-000248-zueoyesj	963	10	A	A	NNP
cord-000248-zueoyesj	963	11	X	x	NN
cord-000248-zueoyesj	963	12	,	,	,
cord-000248-zueoyesj	963	13	P	p	NN
cord-000248-zueoyesj	963	14	X	X	NNP
cord-000248-zueoyesj	963	15	)	)	-RRB-
cord-000248-zueoyesj	963	16	,	,	,
cord-000248-zueoyesj	963	17	where	where	WRB
cord-000248-zueoyesj	963	18	x	x	NN
cord-000248-zueoyesj	963	19	is	be	VBZ
cord-000248-zueoyesj	963	20	the	the	DT
cord-000248-zueoyesj	963	21	value	value	NN
cord-000248-zueoyesj	963	22	of	of	IN
cord-000248-zueoyesj	963	23	a	a	DT
cord-000248-zueoyesj	963	24	random	random	JJ
cord-000248-zueoyesj	963	25	variable	variable	NN
cord-000248-zueoyesj	963	26	,	,	,
cord-000248-zueoyesj	963	27	which	which	WDT
cord-000248-zueoyesj	963	28	takes	take	VBZ
cord-000248-zueoyesj	963	29	on	on	RP
cord-000248-zueoyesj	963	30	one	one	CD
cord-000248-zueoyesj	963	31	of	of	IN
cord-000248-zueoyesj	963	32	a	a	DT
cord-000248-zueoyesj	963	33	set	set	NN
cord-000248-zueoyesj	963	34	of	of	IN
cord-000248-zueoyesj	963	35	possible	possible	JJ
cord-000248-zueoyesj	963	36	values	value	NNS
cord-000248-zueoyesj	963	37	,	,	,
cord-000248-zueoyesj	963	38	A	a	NN
cord-000248-zueoyesj	963	39	X	x	NN
cord-000248-zueoyesj	963	40	~	~	NN
cord-000248-zueoyesj	963	41	f	f	XX
cord-000248-zueoyesj	964	1	a	a	DT
cord-000248-zueoyesj	964	2	1	1	CD
cord-000248-zueoyesj	964	3	,	,	,
cord-000248-zueoyesj	964	4	a	a	DT
cord-000248-zueoyesj	964	5	2	2	CD
cord-000248-zueoyesj	964	6	,	,	,
cord-000248-zueoyesj	964	7	:	:	:
cord-000248-zueoyesj	964	8	:	:	:
cord-000248-zueoyesj	964	9	:	:	:
cord-000248-zueoyesj	964	10	,	,	,
cord-000248-zueoyesj	964	11	a	a	DT
cord-000248-zueoyesj	964	12	i	i	NN
cord-000248-zueoyesj	964	13	,	,	,
cord-000248-zueoyesj	964	14	:	:	:
cord-000248-zueoyesj	964	15	:	:	:
cord-000248-zueoyesj	964	16	:	:	:
cord-000248-zueoyesj	964	17	,	,	,
cord-000248-zueoyesj	964	18	a	a	DT
cord-000248-zueoyesj	964	19	N	n	CD
cord-000248-zueoyesj	964	20	g	g	NN
cord-000248-zueoyesj	964	21	,	,	,
cord-000248-zueoyesj	964	22	having	have	VBG
cord-000248-zueoyesj	964	23	probabilities	probability	NNS
cord-000248-zueoyesj	964	24	P	p	NN
cord-000248-zueoyesj	964	25	X	x	NN
cord-000248-zueoyesj	964	26	~	~	NN
cord-000248-zueoyesj	964	27	f	f	NN
cord-000248-zueoyesj	964	28	p	p	NN
cord-000248-zueoyesj	964	29	1	1	CD
cord-000248-zueoyesj	964	30	,	,	,
cord-000248-zueoyesj	964	31	p	p	NN
cord-000248-zueoyesj	964	32	2	2	CD
cord-000248-zueoyesj	964	33	,	,	,
cord-000248-zueoyesj	964	34	:	:	:
cord-000248-zueoyesj	964	35	:	:	:
cord-000248-zueoyesj	965	1	:	:	:
cord-000248-zueoyesj	965	2	,	,	,
cord-000248-zueoyesj	965	3	p	p	NN
cord-000248-zueoyesj	965	4	N	n	NN
cord-000248-zueoyesj	965	5	g	g	NN
cord-000248-zueoyesj	965	6	,	,	,
cord-000248-zueoyesj	965	7	with	with	IN
cord-000248-zueoyesj	965	8	p(x	p(x	NNPS
cord-000248-zueoyesj	965	9	~	~	NFP
cord-000248-zueoyesj	965	10	a	a	DT
cord-000248-zueoyesj	965	11	i	i	NN
cord-000248-zueoyesj	965	12	)	)	-RRB-
cord-000248-zueoyesj	965	13	~p	~p	.
cord-000248-zueoyesj	966	1	i	i	PRP
cord-000248-zueoyesj	966	2	,	,	,
cord-000248-zueoyesj	966	3	p	p	NN
cord-000248-zueoyesj	966	4	i	i	NN
cord-000248-zueoyesj	966	5	§	§	NN
cord-000248-zueoyesj	966	6	0	0	NFP
cord-000248-zueoyesj	966	7	and	and	CC
cord-000248-zueoyesj	966	8	X	X	VBZ
cord-000248-zueoyesj	966	9	a	a	DT
cord-000248-zueoyesj	966	10	i	i	NN
cord-000248-zueoyesj	966	11	[	[	-LRB-
cord-000248-zueoyesj	966	12	A	a	NN
cord-000248-zueoyesj	966	13	X	x	NN
cord-000248-zueoyesj	966	14	p(x	p(x	NN
cord-000248-zueoyesj	966	15	~	~	NFP
cord-000248-zueoyesj	966	16	a	a	DT
cord-000248-zueoyesj	966	17	i	i	NN
cord-000248-zueoyesj	966	18	)	)	-RRB-
cord-000248-zueoyesj	966	19	~1	~1	NNP
cord-000248-zueoyesj	966	20	.	.	.
cord-000248-zueoyesj	967	1	The	the	DT
cord-000248-zueoyesj	967	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	967	3	Entropy	Entropy	NNP
cord-000248-zueoyesj	967	4	of	of	IN
cord-000248-zueoyesj	967	5	an	an	DT
cord-000248-zueoyesj	967	6	ensemble	ensemble	NN
cord-000248-zueoyesj	967	7	X	x	NN
cord-000248-zueoyesj	967	8	(	(	-LRB-
cord-000248-zueoyesj	967	9	also	also	RB
cord-000248-zueoyesj	967	10	known	know	VBN
cord-000248-zueoyesj	967	11	as	as	IN
cord-000248-zueoyesj	967	12	the	the	DT
cord-000248-zueoyesj	967	13	uncertainty	uncertainty	NN
cord-000248-zueoyesj	967	14	of	of	IN
cord-000248-zueoyesj	967	15	X	X	NNP
cord-000248-zueoyesj	967	16	)	)	-RRB-
cord-000248-zueoyesj	967	17	,	,	,
cord-000248-zueoyesj	967	18	denoted	denote	VBN
cord-000248-zueoyesj	967	19	as	as	IN
cord-000248-zueoyesj	967	20	H[X	H[X	NNP
cord-000248-zueoyesj	967	21	]	]	-RRB-
cord-000248-zueoyesj	967	22	,	,	,
cord-000248-zueoyesj	967	23	is	be	VBZ
cord-000248-zueoyesj	967	24	defined	define	VBN
cord-000248-zueoyesj	967	25	to	to	TO
cord-000248-zueoyesj	967	26	be	be	VB
cord-000248-zueoyesj	967	27	the	the	DT
cord-000248-zueoyesj	967	28	average	average	JJ
cord-000248-zueoyesj	967	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	967	30	information	information	NN
cord-000248-zueoyesj	967	31	content	content	NN
cord-000248-zueoyesj	967	32	.	.	.
cord-000248-zueoyesj	968	1	It	-PRON-	PRP
cord-000248-zueoyesj	968	2	is	be	VBZ
cord-000248-zueoyesj	968	3	the	the	DT
cord-000248-zueoyesj	968	4	average	average	JJ
cord-000248-zueoyesj	968	5	expected	expect	VBN
cord-000248-zueoyesj	968	6	surprisal	surprisal	NNP
cord-000248-zueoyesj	968	7	for	for	IN
cord-000248-zueoyesj	968	8	an	an	DT
cord-000248-zueoyesj	968	9	infinitely	infinitely	RB
cord-000248-zueoyesj	968	10	long	long	JJ
cord-000248-zueoyesj	968	11	series	series	NN
cord-000248-zueoyesj	968	12	of	of	IN
cord-000248-zueoyesj	968	13	experiments	experiment	NNS
cord-000248-zueoyesj	968	14	.	.	.
cord-000248-zueoyesj	969	1	We	-PRON-	PRP
cord-000248-zueoyesj	969	2	use	use	VBP
cord-000248-zueoyesj	969	3	the	the	DT
cord-000248-zueoyesj	969	4	theoretical	theoretical	JJ
cord-000248-zueoyesj	969	5	frequencies	frequency	NNS
cord-000248-zueoyesj	969	6	to	to	TO
cord-000248-zueoyesj	969	7	compute	compute	VB
cord-000248-zueoyesj	969	8	this	this	DT
cord-000248-zueoyesj	969	9	average	average	NN
cord-000248-zueoyesj	969	10	,	,	,
cord-000248-zueoyesj	969	11	and	and	CC
cord-000248-zueoyesj	969	12	then	then	RB
cord-000248-zueoyesj	969	13	we	-PRON-	PRP
cord-000248-zueoyesj	969	14	have	have	VBP
cord-000248-zueoyesj	969	15	Suppose	Suppose	VBN
cord-000248-zueoyesj	969	16	that	that	IN
cord-000248-zueoyesj	969	17	we	-PRON-	PRP
cord-000248-zueoyesj	969	18	have	have	VBP
cord-000248-zueoyesj	969	19	a	a	DT
cord-000248-zueoyesj	969	20	fair	fair	JJ
cord-000248-zueoyesj	969	21	dice	dice	NN
cord-000248-zueoyesj	969	22	,	,	,
cord-000248-zueoyesj	969	23	the	the	DT
cord-000248-zueoyesj	969	24	theoretical	theoretical	JJ
cord-000248-zueoyesj	969	25	frequency	frequency	NN
cord-000248-zueoyesj	969	26	of	of	IN
cord-000248-zueoyesj	969	27	an	an	DT
cord-000248-zueoyesj	969	28	event	event	NN
cord-000248-zueoyesj	969	29	'	'	``
cord-000248-zueoyesj	969	30	the	the	DT
cord-000248-zueoyesj	969	31	dice	dice	NN
cord-000248-zueoyesj	969	32	shows	show	VBZ
cord-000248-zueoyesj	969	33	a	a	DT
cord-000248-zueoyesj	969	34	three	three	CD
cord-000248-zueoyesj	969	35	'	'	''
cord-000248-zueoyesj	969	36	is	be	VBZ
cord-000248-zueoyesj	969	37	1/6	1/6	DT
cord-000248-zueoyesj	969	38	,	,	,
cord-000248-zueoyesj	969	39	(	(	-LRB-
cord-000248-zueoyesj	969	40	if	if	IN
cord-000248-zueoyesj	969	41	the	the	DT
cord-000248-zueoyesj	969	42	dice	dice	NN
cord-000248-zueoyesj	969	43	is	be	VBZ
cord-000248-zueoyesj	969	44	assumed	assume	VBN
cord-000248-zueoyesj	969	45	fair	fair	JJ
cord-000248-zueoyesj	969	46	,	,	,
cord-000248-zueoyesj	969	47	the	the	DT
cord-000248-zueoyesj	969	48	theoretical	theoretical	JJ
cord-000248-zueoyesj	969	49	frequency	frequency	NN
cord-000248-zueoyesj	969	50	is	be	VBZ
cord-000248-zueoyesj	969	51	the	the	DT
cord-000248-zueoyesj	969	52	same	same	JJ
cord-000248-zueoyesj	969	53	for	for	IN
cord-000248-zueoyesj	969	54	any	any	DT
cord-000248-zueoyesj	969	55	number	number	NN
cord-000248-zueoyesj	969	56	from	from	IN
cord-000248-zueoyesj	969	57	1	1	CD
cord-000248-zueoyesj	969	58	to	to	IN
cord-000248-zueoyesj	969	59	6	6	CD
cord-000248-zueoyesj	969	60	)	)	-RRB-
cord-000248-zueoyesj	969	61	.	.	.
cord-000248-zueoyesj	970	1	In	in	IN
cord-000248-zueoyesj	970	2	that	that	DT
cord-000248-zueoyesj	970	3	case	case	NN
cord-000248-zueoyesj	970	4	a	a	DT
cord-000248-zueoyesj	970	5	hypothetical	hypothetical	JJ
cord-000248-zueoyesj	970	6	experimentalist	experimentalist	NN
cord-000248-zueoyesj	970	7	guessing	guessing	NN
cord-000248-zueoyesj	970	8	will	will	MD
cord-000248-zueoyesj	970	9	have	have	VB
cord-000248-zueoyesj	970	10	an	an	DT
cord-000248-zueoyesj	970	11	average	average	JJ
cord-000248-zueoyesj	970	12	expected	expect	VBN
cord-000248-zueoyesj	970	13	surprise	surprise	NN
cord-000248-zueoyesj	970	14	of	of	IN
cord-000248-zueoyesj	970	15	H[X	H[X	NNP
cord-000248-zueoyesj	970	16	]	]	-RRB-
cord-000248-zueoyesj	971	1	=	=	SYM
cord-000248-zueoyesj	971	2	log	log	NN
cord-000248-zueoyesj	971	3	2	2	CD
cord-000248-zueoyesj	971	4	(	(	-LRB-
cord-000248-zueoyesj	971	5	6	6	CD
cord-000248-zueoyesj	971	6	)	)	-RRB-
cord-000248-zueoyesj	971	7	.	.	.
cord-000248-zueoyesj	972	1	We	-PRON-	PRP
cord-000248-zueoyesj	972	2	note	note	VBP
cord-000248-zueoyesj	972	3	the	the	DT
cord-000248-zueoyesj	972	4	two	two	CD
cord-000248-zueoyesj	972	5	natural	natural	JJ
cord-000248-zueoyesj	972	6	bounds	bound	NNS
cord-000248-zueoyesj	972	7	that	that	WDT
cord-000248-zueoyesj	972	8	the	the	DT
cord-000248-zueoyesj	972	9	entropy	entropy	NN
cord-000248-zueoyesj	972	10	can	can	MD
cord-000248-zueoyesj	972	11	have	have	VB
cord-000248-zueoyesj	972	12	.	.	.
cord-000248-zueoyesj	973	1	The	the	DT
cord-000248-zueoyesj	973	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	973	3	Entropy	Entropy	NNP
cord-000248-zueoyesj	973	4	of	of	IN
cord-000248-zueoyesj	973	5	an	an	DT
cord-000248-zueoyesj	973	6	ensemble	ensemble	NN
cord-000248-zueoyesj	973	7	X	x	NN
cord-000248-zueoyesj	973	8	is	be	VBZ
cord-000248-zueoyesj	973	9	always	always	RB
cord-000248-zueoyesj	973	10	greater	great	JJR
cord-000248-zueoyesj	973	11	or	or	CC
cord-000248-zueoyesj	973	12	equal	equal	JJ
cord-000248-zueoyesj	973	13	to	to	IN
cord-000248-zueoyesj	973	14	zero	zero	CD
cord-000248-zueoyesj	973	15	.	.	.
cord-000248-zueoyesj	974	1	It	-PRON-	PRP
cord-000248-zueoyesj	974	2	can	can	MD
cord-000248-zueoyesj	974	3	only	only	RB
cord-000248-zueoyesj	974	4	be	be	VB
cord-000248-zueoyesj	974	5	zero	zero	CD
cord-000248-zueoyesj	974	6	if	if	IN
cord-000248-zueoyesj	974	7	p(x	p(x	NNPS
cord-000248-zueoyesj	974	8	~	~	NFP
cord-000248-zueoyesj	974	9	a	a	DT
cord-000248-zueoyesj	974	10	i	i	NN
cord-000248-zueoyesj	974	11	)	)	-RRB-
cord-000248-zueoyesj	974	12	~1	~1	NFP
cord-000248-zueoyesj	974	13	for	for	IN
cord-000248-zueoyesj	974	14	only	only	RB
cord-000248-zueoyesj	974	15	one	one	CD
cord-000248-zueoyesj	974	16	of	of	IN
cord-000248-zueoyesj	974	17	the	the	DT
cord-000248-zueoyesj	974	18	N	n	CD
cord-000248-zueoyesj	974	19	elements	element	NNS
cord-000248-zueoyesj	974	20	of	of	IN
cord-000248-zueoyesj	974	21	A	a	NN
cord-000248-zueoyesj	974	22	X	x	NN
cord-000248-zueoyesj	974	23	~	~	NN
cord-000248-zueoyesj	974	24	f	f	NN
cord-000248-zueoyesj	974	25	a	a	DT
cord-000248-zueoyesj	974	26	1	1	CD
cord-000248-zueoyesj	974	27	,	,	,
cord-000248-zueoyesj	974	28	a	a	DT
cord-000248-zueoyesj	974	29	2	2	CD
cord-000248-zueoyesj	974	30	,	,	,
cord-000248-zueoyesj	974	31	:	:	:
cord-000248-zueoyesj	974	32	:	:	:
cord-000248-zueoyesj	974	33	:	:	:
cord-000248-zueoyesj	974	34	,	,	,
cord-000248-zueoyesj	974	35	a	a	DT
cord-000248-zueoyesj	974	36	i	i	NN
cord-000248-zueoyesj	974	37	,	,	,
cord-000248-zueoyesj	974	38	:	:	:
cord-000248-zueoyesj	974	39	:	:	:
cord-000248-zueoyesj	974	40	:	:	:
cord-000248-zueoyesj	974	41	,	,	,
cord-000248-zueoyesj	974	42	a	a	DT
cord-000248-zueoyesj	974	43	N	n	CD
cord-000248-zueoyesj	974	44	g.	g.	NN
cord-000248-zueoyesj	975	1	On	on	IN
cord-000248-zueoyesj	975	2	the	the	DT
cord-000248-zueoyesj	975	3	other	other	JJ
cord-000248-zueoyesj	975	4	hand	hand	NN
cord-000248-zueoyesj	975	5	,	,	,
cord-000248-zueoyesj	975	6	the	the	DT
cord-000248-zueoyesj	975	7	Shannon	Shannon	NNP
cord-000248-zueoyesj	975	8	Entropy	Entropy	NNP
cord-000248-zueoyesj	975	9	is	be	VBZ
cord-000248-zueoyesj	975	10	maximized	maximize	VBN
cord-000248-zueoyesj	975	11	in	in	IN
cord-000248-zueoyesj	975	12	the	the	DT
cord-000248-zueoyesj	975	13	case	case	NN
cord-000248-zueoyesj	975	14	that	that	IN
cord-000248-zueoyesj	975	15	p(x	p(x	UH
cord-000248-zueoyesj	975	16	~	~	NFP
cord-000248-zueoyesj	975	17	a	a	DT
cord-000248-zueoyesj	975	18	i	i	NN
cord-000248-zueoyesj	975	19	)	)	-RRB-
cord-000248-zueoyesj	976	1	~1	~1	LS
cord-000248-zueoyesj	977	1	=	=	SYM
cord-000248-zueoyesj	977	2	N.	n.	NN
cord-000248-zueoyesj	978	1	This	this	DT
cord-000248-zueoyesj	978	2	is	be	VBZ
cord-000248-zueoyesj	978	3	the	the	DT
cord-000248-zueoyesj	978	4	so	so	RB
cord-000248-zueoyesj	978	5	-	-	HYPH
cord-000248-zueoyesj	978	6	called	call	VBN
cord-000248-zueoyesj	978	7	'	'	''
cord-000248-zueoyesj	978	8	'	'	``
cord-000248-zueoyesj	978	9	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	978	10	distribution	distribution	NN
cord-000248-zueoyesj	978	11	'	'	''
cord-000248-zueoyesj	978	12	'	'	''
cord-000248-zueoyesj	978	13	,	,	,
cord-000248-zueoyesj	978	14	a	a	DT
cord-000248-zueoyesj	978	15	uniform	uniform	JJ
cord-000248-zueoyesj	978	16	probability	probability	NN
cord-000248-zueoyesj	978	17	distribution	distribution	NN
cord-000248-zueoyesj	978	18	over	over	IN
cord-000248-zueoyesj	978	19	the	the	DT
cord-000248-zueoyesj	978	20	finite	finite	JJ
cord-000248-zueoyesj	978	21	set	set	NN
cord-000248-zueoyesj	978	22	.	.	.
cord-000248-zueoyesj	979	1	Transcriptional	Transcriptional	NNP
cord-000248-zueoyesj	979	2	Shannon	Shannon	NNP
cord-000248-zueoyesj	979	3	Entropy	Entropy	NNP
cord-000248-zueoyesj	979	4	.	.	.
cord-000248-zueoyesj	980	1	Let	let	VB
cord-000248-zueoyesj	980	2	f	f	NNP
cord-000248-zueoyesj	980	3	(	(	-LRB-
cord-000248-zueoyesj	980	4	j	j	NNP
cord-000248-zueoyesj	980	5	)	)	-RRB-
cord-000248-zueoyesj	980	6	i	i	PRP
cord-000248-zueoyesj	980	7	the	the	DT
cord-000248-zueoyesj	980	8	expression	expression	NN
cord-000248-zueoyesj	980	9	value	value	NN
cord-000248-zueoyesj	980	10	of	of	IN
cord-000248-zueoyesj	980	11	probe	probe	NN
cord-000248-zueoyesj	981	1	i	i	PRP
cord-000248-zueoyesj	981	2	(	(	-LRB-
cord-000248-zueoyesj	981	3	i	i	NN
cord-000248-zueoyesj	981	4	=	=	SYM
cord-000248-zueoyesj	981	5	1	1	CD
cord-000248-zueoyesj	981	6	,	,	,
cord-000248-zueoyesj	981	7	…	…	NFP
cord-000248-zueoyesj	981	8	,	,	,
cord-000248-zueoyesj	981	9	N	n	CD
cord-000248-zueoyesj	981	10	)	)	-RRB-
cord-000248-zueoyesj	981	11	on	on	IN
cord-000248-zueoyesj	981	12	sample	sample	NN
cord-000248-zueoyesj	981	13	j	j	NNP
cord-000248-zueoyesj	981	14	(	(	-LRB-
cord-000248-zueoyesj	981	15	j	j	NNP
cord-000248-zueoyesj	981	16	=	=	SYM
cord-000248-zueoyesj	981	17	1	1	CD
cord-000248-zueoyesj	981	18	,	,	,
cord-000248-zueoyesj	981	19	…	…	NFP
cord-000248-zueoyesj	981	20	,	,	,
cord-000248-zueoyesj	981	21	M	M	NNP
cord-000248-zueoyesj	981	22	)	)	-RRB-
cord-000248-zueoyesj	981	23	.	.	.
cord-000248-zueoyesj	982	1	For	for	IN
cord-000248-zueoyesj	982	2	each	each	DT
cord-000248-zueoyesj	982	3	sample	sample	NN
cord-000248-zueoyesj	982	4	j	j	NN
cord-000248-zueoyesj	982	5	we	-PRON-	PRP
cord-000248-zueoyesj	982	6	first	first	RB
cord-000248-zueoyesj	982	7	normalize	normalize	VBP
cord-000248-zueoyesj	982	8	the	the	DT
cord-000248-zueoyesj	982	9	expression	expression	NN
cord-000248-zueoyesj	982	10	values	value	NNS
cord-000248-zueoyesj	982	11	.	.	.
cord-000248-zueoyesj	983	1	We	-PRON-	PRP
cord-000248-zueoyesj	983	2	interpret	interpret	VBP
cord-000248-zueoyesj	983	3	them	-PRON-	PRP
cord-000248-zueoyesj	983	4	as	as	IN
cord-000248-zueoyesj	983	5	the	the	DT
cord-000248-zueoyesj	983	6	theoretical	theoretical	JJ
cord-000248-zueoyesj	983	7	frequency	frequency	NN
cord-000248-zueoyesj	983	8	of	of	IN
cord-000248-zueoyesj	983	9	a	a	DT
cord-000248-zueoyesj	983	10	single	single	JJ
cord-000248-zueoyesj	983	11	hybridization	hybridization	NN
cord-000248-zueoyesj	983	12	event	event	NN
cord-000248-zueoyesj	983	13	.	.	.
cord-000248-zueoyesj	984	1	We	-PRON-	PRP
cord-000248-zueoyesj	984	2	then	then	RB
cord-000248-zueoyesj	984	3	define	define	VBP
cord-000248-zueoyesj	984	4	a	a	DT
cord-000248-zueoyesj	984	5	probability	probability	NN
cord-000248-zueoyesj	984	6	distribution	distribution	NN
cord-000248-zueoyesj	984	7	function	function	NN
cord-000248-zueoyesj	984	8	(	(	-LRB-
cord-000248-zueoyesj	984	9	PDF	PDF	NNP
cord-000248-zueoyesj	984	10	)	)	-RRB-
cord-000248-zueoyesj	984	11	over	over	IN
cord-000248-zueoyesj	984	12	a	a	DT
cord-000248-zueoyesj	984	13	finite	finite	JJ
cord-000248-zueoyesj	984	14	set	set	NN
cord-000248-zueoyesj	984	15	as	as	IN
cord-000248-zueoyesj	984	16	:	:	:
cord-000248-zueoyesj	985	1	The	the	DT
cord-000248-zueoyesj	985	2	uniform	uniform	NN
cord-000248-zueoyesj	985	3	(	(	-LRB-
cord-000248-zueoyesj	985	4	equiprobably	equiprobably	NNP
cord-000248-zueoyesj	985	5	)	)	-RRB-
cord-000248-zueoyesj	985	6	distribution	distribution	NN
cord-000248-zueoyesj	985	7	is	be	VBZ
cord-000248-zueoyesj	985	8	defined	define	VBN
cord-000248-zueoyesj	985	9	as	as	IN
cord-000248-zueoyesj	985	10	i	i	PRP
cord-000248-zueoyesj	985	11	Let	let	VBP
cord-000248-zueoyesj	985	12	H	h	NN
cord-000248-zueoyesj	985	13	e	e	NN
cord-000248-zueoyesj	986	1	~H	~H	NFP
cord-000248-zueoyesj	986	2	½P	½P	NNP
cord-000248-zueoyesj	986	3	e	e	LS
cord-000248-zueoyesj	986	4	~log	~log	NNP
cord-000248-zueoyesj	986	5	2	2	CD
cord-000248-zueoyesj	986	6	N	n	CD
cord-000248-zueoyesj	986	7	,	,	,
cord-000248-zueoyesj	986	8	then	then	RB
cord-000248-zueoyesj	986	9	in	in	IN
cord-000248-zueoyesj	986	10	this	this	DT
cord-000248-zueoyesj	986	11	paper	paper	NN
cord-000248-zueoyesj	986	12	we	-PRON-	PRP
cord-000248-zueoyesj	986	13	always	always	RB
cord-000248-zueoyesj	986	14	use	use	VBP
cord-000248-zueoyesj	986	15	the	the	DT
cord-000248-zueoyesj	986	16	Normalized	Normalized	NNP
cord-000248-zueoyesj	986	17	Shannon	Shannon	NNP
cord-000248-zueoyesj	986	18	Entropy	Entropy	NNP
cord-000248-zueoyesj	986	19	,	,	,
cord-000248-zueoyesj	986	20	defined	define	VBN
cord-000248-zueoyesj	986	21	as	as	IN
cord-000248-zueoyesj	986	22	:	:	:
cord-000248-zueoyesj	986	23	i	i	NN
cord-000248-zueoyesj	986	24	H	h	NN
cord-000248-zueoyesj	986	25	e	e	NN
cord-000248-zueoyesj	986	26	,	,	,
cord-000248-zueoyesj	986	27	j~1	j~1	NNP
cord-000248-zueoyesj	986	28	,	,	,
cord-000248-zueoyesj	986	29	.	.	.
cord-000248-zueoyesj	986	30	.	.	.
cord-000248-zueoyesj	986	31	.	.	.
cord-000248-zueoyesj	987	1	,	,	,
cord-000248-zueoyesj	988	1	M	M	NNP
cord-000248-zueoyesj	989	1	The	the	DT
cord-000248-zueoyesj	989	2	Jensen	Jensen	NNP
cord-000248-zueoyesj	989	3	-	-	HYPH
cord-000248-zueoyesj	989	4	Shannon	Shannon	NNP
cord-000248-zueoyesj	989	5	divergence	divergence	NN
cord-000248-zueoyesj	989	6	and	and	CC
cord-000248-zueoyesj	989	7	the	the	DT
cord-000248-zueoyesj	989	8	Statistical	statistical	JJ
cord-000248-zueoyesj	989	9	complexity	complexity	NN
cord-000248-zueoyesj	989	10	measures	measure	NNS
cord-000248-zueoyesj	989	11	Given	give	VBN
cord-000248-zueoyesj	989	12	a	a	DT
cord-000248-zueoyesj	989	13	probability	probability	NN
cord-000248-zueoyesj	989	14	distribution	distribution	NN
cord-000248-zueoyesj	989	15	function	function	NN
cord-000248-zueoyesj	989	16	over	over	IN
cord-000248-zueoyesj	989	17	a	a	DT
cord-000248-zueoyesj	989	18	discrete	discrete	JJ
cord-000248-zueoyesj	989	19	finite	finite	JJ
cord-000248-zueoyesj	989	20	set	set	NN
cord-000248-zueoyesj	989	21	,	,	,
cord-000248-zueoyesj	989	22	is	be	VBZ
cord-000248-zueoyesj	989	23	then	then	RB
cord-000248-zueoyesj	989	24	straightforward	straightforward	JJ
cord-000248-zueoyesj	989	25	to	to	TO
cord-000248-zueoyesj	989	26	calculate	calculate	VB
cord-000248-zueoyesj	989	27	its	-PRON-	PRP$
cord-000248-zueoyesj	989	28	Normalized	Normalized	NNP
cord-000248-zueoyesj	989	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	989	30	Entropy	Entropy	NNP
cord-000248-zueoyesj	989	31	if	if	IN
cord-000248-zueoyesj	989	32	we	-PRON-	PRP
cord-000248-zueoyesj	989	33	have	have	VBP
cord-000248-zueoyesj	989	34	the	the	DT
cord-000248-zueoyesj	989	35	theoretical	theoretical	JJ
cord-000248-zueoyesj	989	36	frequencies	frequency	NNS
cord-000248-zueoyesj	989	37	.	.	.
cord-000248-zueoyesj	990	1	Several	several	JJ
cord-000248-zueoyesj	990	2	measures	measure	NNS
cord-000248-zueoyesj	990	3	of	of	IN
cord-000248-zueoyesj	990	4	'	'	''
cord-000248-zueoyesj	990	5	'	'	``
cord-000248-zueoyesj	990	6	complexity	complexity	NN
cord-000248-zueoyesj	990	7	'	'	''
cord-000248-zueoyesj	990	8	'	'	''
cord-000248-zueoyesj	990	9	of	of	IN
cord-000248-zueoyesj	990	10	a	a	DT
cord-000248-zueoyesj	990	11	probability	probability	NN
cord-000248-zueoyesj	990	12	distribution	distribution	NN
cord-000248-zueoyesj	990	13	function	function	NN
cord-000248-zueoyesj	990	14	have	have	VBP
cord-000248-zueoyesj	990	15	been	be	VBN
cord-000248-zueoyesj	990	16	proposed	propose	VBN
cord-000248-zueoyesj	990	17	.	.	.
cord-000248-zueoyesj	991	1	In	in	IN
cord-000248-zueoyesj	991	2	this	this	DT
cord-000248-zueoyesj	991	3	work	work	NN
cord-000248-zueoyesj	991	4	we	-PRON-	PRP
cord-000248-zueoyesj	991	5	have	have	VBP
cord-000248-zueoyesj	991	6	used	use	VBN
cord-000248-zueoyesj	991	7	Statistical	Statistical	NNP
cord-000248-zueoyesj	991	8	Complexity	Complexity	NNP
cord-000248-zueoyesj	991	9	measures	measure	NNS
cord-000248-zueoyesj	991	10	.	.	.
cord-000248-zueoyesj	992	1	All	all	PDT
cord-000248-zueoyesj	992	2	the	the	DT
cord-000248-zueoyesj	992	3	complexity	complexity	NN
cord-000248-zueoyesj	992	4	measures	measure	NNS
cord-000248-zueoyesj	992	5	used	use	VBN
cord-000248-zueoyesj	992	6	in	in	IN
cord-000248-zueoyesj	992	7	this	this	DT
cord-000248-zueoyesj	992	8	work	work	NN
cord-000248-zueoyesj	992	9	are	be	VBP
cord-000248-zueoyesj	992	10	the	the	DT
cord-000248-zueoyesj	992	11	product	product	NN
cord-000248-zueoyesj	992	12	of	of	IN
cord-000248-zueoyesj	992	13	a	a	DT
cord-000248-zueoyesj	992	14	Normalized	Normalized	NNP
cord-000248-zueoyesj	992	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	992	16	Entropy	Entropy	NNP
cord-000248-zueoyesj	992	17	of	of	IN
cord-000248-zueoyesj	992	18	the	the	DT
cord-000248-zueoyesj	992	19	probability	probability	NN
cord-000248-zueoyesj	992	20	distribution	distribution	NN
cord-000248-zueoyesj	992	21	function	function	NN
cord-000248-zueoyesj	992	22	,	,	,
cord-000248-zueoyesj	992	23	and	and	CC
cord-000248-zueoyesj	992	24	a	a	DT
cord-000248-zueoyesj	992	25	divergence	divergence	NN
cord-000248-zueoyesj	992	26	measure	measure	NN
cord-000248-zueoyesj	992	27	to	to	IN
cord-000248-zueoyesj	992	28	a	a	DT
cord-000248-zueoyesj	992	29	reference	reference	NN
cord-000248-zueoyesj	992	30	probability	probability	NN
cord-000248-zueoyesj	992	31	distribution	distribution	NN
cord-000248-zueoyesj	992	32	function	function	NN
cord-000248-zueoyesj	992	33	.	.	.
cord-000248-zueoyesj	993	1	We	-PRON-	PRP
cord-000248-zueoyesj	993	2	follow	follow	VBP
cord-000248-zueoyesj	993	3	earlier	early	JJR
cord-000248-zueoyesj	993	4	proposals	proposal	NNS
cord-000248-zueoyesj	993	5	by	by	IN
cord-000248-zueoyesj	993	6	López	López	NNP
cord-000248-zueoyesj	993	7	-	-	HYPH
cord-000248-zueoyesj	993	8	Ruiz	Ruiz	NNP
cord-000248-zueoyesj	993	9	,	,	,
cord-000248-zueoyesj	993	10	Mancini	Mancini	NNP
cord-000248-zueoyesj	993	11	and	and	CC
cord-000248-zueoyesj	993	12	Calbet	Calbet	NNP
cord-000248-zueoyesj	993	13	who	who	WP
cord-000248-zueoyesj	993	14	first	first	RB
cord-000248-zueoyesj	993	15	introduced	introduce	VBD
cord-000248-zueoyesj	993	16	a	a	DT
cord-000248-zueoyesj	993	17	statistical	statistical	JJ
cord-000248-zueoyesj	993	18	complexity	complexity	NN
cord-000248-zueoyesj	993	19	measure	measure	NN
cord-000248-zueoyesj	993	20	based	base	VBN
cord-000248-zueoyesj	993	21	on	on	IN
cord-000248-zueoyesj	993	22	such	such	PDT
cord-000248-zueoyesj	993	23	a	a	DT
cord-000248-zueoyesj	993	24	product	product	NN
cord-000248-zueoyesj	993	25	in	in	IN
cord-000248-zueoyesj	993	26	[	[	-LRB-
cord-000248-zueoyesj	993	27	797	797	CD
cord-000248-zueoyesj	993	28	]	]	-RRB-
cord-000248-zueoyesj	993	29	.	.	.
cord-000248-zueoyesj	994	1	The	the	DT
cord-000248-zueoyesj	994	2	LMC	LMC	NNP
cord-000248-zueoyesj	994	3	-	-	HYPH
cord-000248-zueoyesj	994	4	Statistical	Statistical	NNP
cord-000248-zueoyesj	994	5	Complexity	Complexity	NNP
cord-000248-zueoyesj	994	6	is	be	VBZ
cord-000248-zueoyesj	994	7	the	the	DT
cord-000248-zueoyesj	994	8	product	product	NN
cord-000248-zueoyesj	994	9	of	of	IN
cord-000248-zueoyesj	994	10	the	the	DT
cord-000248-zueoyesj	994	11	Normalized	Normalized	NNP
cord-000248-zueoyesj	994	12	Shannon	Shannon	NNP
cord-000248-zueoyesj	994	13	Entropy	Entropy	NNP
cord-000248-zueoyesj	994	14	,	,	,
cord-000248-zueoyesj	994	15	H[P	H[P	NNP
cord-000248-zueoyesj	994	16	]	]	-RRB-
cord-000248-zueoyesj	994	17	,	,	,
cord-000248-zueoyesj	994	18	times	time	NNS
cord-000248-zueoyesj	994	19	the	the	DT
cord-000248-zueoyesj	994	20	disequilibrium	disequilibrium	NN
cord-000248-zueoyesj	994	21	,	,	,
cord-000248-zueoyesj	994	22	Q[P	Q[P	NNP
cord-000248-zueoyesj	994	23	]	]	-RRB-
cord-000248-zueoyesj	994	24	;	;	:
cord-000248-zueoyesj	994	25	the	the	DT
cord-000248-zueoyesj	994	26	latter	latter	JJ
cord-000248-zueoyesj	994	27	given	give	VBN
cord-000248-zueoyesj	994	28	by	by	IN
cord-000248-zueoyesj	994	29	the	the	DT
cord-000248-zueoyesj	994	30	Euclidean	euclidean	JJ
cord-000248-zueoyesj	994	31	distance	distance	NN
cord-000248-zueoyesj	994	32	from	from	IN
cord-000248-zueoyesj	994	33	P	p	NN
cord-000248-zueoyesj	994	34	to	to	IN
cord-000248-zueoyesj	994	35	P	p	NN
cord-000248-zueoyesj	994	36	e	e	NN
cord-000248-zueoyesj	994	37	,	,	,
cord-000248-zueoyesj	994	38	the	the	DT
cord-000248-zueoyesj	994	39	uniform	uniform	JJ
cord-000248-zueoyesj	994	40	probability	probability	NN
cord-000248-zueoyesj	994	41	distribution	distribution	NN
cord-000248-zueoyesj	994	42	over	over	IN
cord-000248-zueoyesj	994	43	the	the	DT
cord-000248-zueoyesj	994	44	ensemble	ensemble	NN
cord-000248-zueoyesj	994	45	.	.	.
cord-000248-zueoyesj	995	1	In	in	IN
cord-000248-zueoyesj	995	2	this	this	DT
cord-000248-zueoyesj	995	3	paper	paper	NN
cord-000248-zueoyesj	995	4	we	-PRON-	PRP
cord-000248-zueoyesj	995	5	used	use	VBD
cord-000248-zueoyesj	995	6	a	a	DT
cord-000248-zueoyesj	995	7	later	later	JJ
cord-000248-zueoyesj	995	8	modification	modification	NN
cord-000248-zueoyesj	995	9	which	which	WDT
cord-000248-zueoyesj	995	10	we	-PRON-	PRP
cord-000248-zueoyesj	995	11	refer	refer	VBP
cord-000248-zueoyesj	995	12	as	as	IN
cord-000248-zueoyesj	995	13	the	the	DT
cord-000248-zueoyesj	995	14	MPR	MPR	NNP
cord-000248-zueoyesj	995	15	-	-	HYPH
cord-000248-zueoyesj	995	16	Statistical	Statistical	NNP
cord-000248-zueoyesj	995	17	Complexity	Complexity	NNP
cord-000248-zueoyesj	995	18	[	[	-LRB-
cord-000248-zueoyesj	995	19	43	43	CD
cord-000248-zueoyesj	995	20	]	]	-RRB-
cord-000248-zueoyesj	995	21	which	which	WDT
cord-000248-zueoyesj	995	22	replaces	replace	VBZ
cord-000248-zueoyesj	995	23	the	the	DT
cord-000248-zueoyesj	995	24	Euclidean	euclidean	JJ
cord-000248-zueoyesj	995	25	distance	distance	NN
cord-000248-zueoyesj	995	26	between	between	IN
cord-000248-zueoyesj	995	27	P	p	NN
cord-000248-zueoyesj	995	28	to	to	IN
cord-000248-zueoyesj	995	29	P	p	NN
cord-000248-zueoyesj	995	30	e	e	NN
cord-000248-zueoyesj	995	31	by	by	IN
cord-000248-zueoyesj	995	32	the	the	DT
cord-000248-zueoyesj	995	33	Jensen	Jensen	NNP
cord-000248-zueoyesj	995	34	-	-	HYPH
cord-000248-zueoyesj	995	35	Shannon	Shannon	NNP
cord-000248-zueoyesj	995	36	divergence	divergence	NN
cord-000248-zueoyesj	995	37	[	[	-LRB-
cord-000248-zueoyesj	995	38	788	788	CD
cord-000248-zueoyesj	995	39	,	,	,
cord-000248-zueoyesj	995	40	798	798	CD
cord-000248-zueoyesj	995	41	]	]	-RRB-
cord-000248-zueoyesj	995	42	.	.	.
cord-000248-zueoyesj	996	1	The	the	DT
cord-000248-zueoyesj	996	2	Jensen	Jensen	NNP
cord-000248-zueoyesj	996	3	-	-	HYPH
cord-000248-zueoyesj	996	4	Shannon	Shannon	NNP
cord-000248-zueoyesj	996	5	divergence	divergence	NN
cord-000248-zueoyesj	996	6	is	be	VBZ
cord-000248-zueoyesj	996	7	linked	link	VBN
cord-000248-zueoyesj	996	8	in	in	IN
cord-000248-zueoyesj	996	9	physics	physics	NN
cord-000248-zueoyesj	996	10	to	to	IN
cord-000248-zueoyesj	996	11	the	the	DT
cord-000248-zueoyesj	996	12	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	996	13	length	length	NN
cord-000248-zueoyesj	996	14	[	[	-LRB-
cord-000248-zueoyesj	996	15	799	799	CD
cord-000248-zueoyesj	996	16	,	,	,
cord-000248-zueoyesj	996	17	800	800	CD
cord-000248-zueoyesj	996	18	,	,	,
cord-000248-zueoyesj	996	19	801	801	CD
cord-000248-zueoyesj	996	20	,	,	,
cord-000248-zueoyesj	996	21	802	802	CD
cord-000248-zueoyesj	996	22	]	]	-RRB-
cord-000248-zueoyesj	996	23	.	.	.
cord-000248-zueoyesj	997	1	We	-PRON-	PRP
cord-000248-zueoyesj	997	2	define	define	VBP
cord-000248-zueoyesj	997	3	the	the	DT
cord-000248-zueoyesj	997	4	MPR	MPR	NNP
cord-000248-zueoyesj	997	5	-	-	HYPH
cord-000248-zueoyesj	997	6	Statistical	statistical	JJ
cord-000248-zueoyesj	997	7	complexity	complexity	NN
cord-000248-zueoyesj	997	8	[	[	-LRB-
cord-000248-zueoyesj	997	9	790	790	CD
cord-000248-zueoyesj	997	10	]	]	-RRB-
cord-000248-zueoyesj	997	11	as	as	IN
cord-000248-zueoyesj	997	12	:	:	:
cord-000248-zueoyesj	997	13	where	where	WRB
cord-000248-zueoyesj	997	14	Q	Q	NNP
cord-000248-zueoyesj	997	15	P	P	NNP
cord-000248-zueoyesj	997	16	(	(	-LRB-
cord-000248-zueoyesj	997	17	j	j	NNP
cord-000248-zueoyesj	997	18	)	)	-RRB-
cord-000248-zueoyesj	997	19	,	,	,
cord-000248-zueoyesj	997	20	P	p	NN
cord-000248-zueoyesj	997	21	e	e	NN
cord-000248-zueoyesj	997	22	Â	â	NN
cord-000248-zueoyesj	998	1	Ã	Ã	NNP
cord-000248-zueoyesj	998	2	Q	Q	NNP
cord-000248-zueoyesj	998	3	0	0	NN
cord-000248-zueoyesj	998	4	J	J	NNP
cord-000248-zueoyesj	998	5	s	s	NNP
cord-000248-zueoyesj	998	6	P	P	NNP
cord-000248-zueoyesj	998	7	(	(	-LRB-
cord-000248-zueoyesj	998	8	j	j	NNP
cord-000248-zueoyesj	998	9	)	)	-RRB-
cord-000248-zueoyesj	998	10	,	,	.
cord-000248-zueoyesj	999	1	P	p	NN
cord-000248-zueoyesj	999	2	e	e	NN
cord-000248-zueoyesj	999	3	Â	â	NN
cord-000248-zueoyesj	999	4	Ã	ã	NN
cord-000248-zueoyesj	999	5	,	,	,
cord-000248-zueoyesj	999	6	Q	q	NN
cord-000248-zueoyesj	999	7	0	0	NFP
cord-000248-zueoyesj	999	8	is	be	VBZ
cord-000248-zueoyesj	999	9	a	a	DT
cord-000248-zueoyesj	999	10	normalization	normalization	NN
cord-000248-zueoyesj	999	11	factor	factor	NN
cord-000248-zueoyesj	999	12	,	,	,
cord-000248-zueoyesj	999	13	and	and	CC
cord-000248-zueoyesj	999	14	J	J	NNP
cord-000248-zueoyesj	999	15	s	s	NNP
cord-000248-zueoyesj	999	16	P	P	NNP
cord-000248-zueoyesj	999	17	(	(	-LRB-
cord-000248-zueoyesj	999	18	1	1	CD
cord-000248-zueoyesj	999	19	)	)	-RRB-
cord-000248-zueoyesj	999	20	,	,	,
cord-000248-zueoyesj	999	21	P	p	NN
cord-000248-zueoyesj	999	22	(	(	-LRB-
cord-000248-zueoyesj	999	23	2	2	CD
cord-000248-zueoyesj	999	24	)	)	-RRB-
cord-000248-zueoyesj	1000	1	Â	â	NN
cord-000248-zueoyesj	1001	1	Ã	Ã	NNP
cord-000248-zueoyesj	1001	2	is	be	VBZ
cord-000248-zueoyesj	1001	3	the	the	DT
cord-000248-zueoyesj	1001	4	Jensen	Jensen	NNP
cord-000248-zueoyesj	1001	5	-	-	HYPH
cord-000248-zueoyesj	1001	6	Shannon	Shannon	NNP
cord-000248-zueoyesj	1001	7	's	's	POS
cord-000248-zueoyesj	1001	8	divergence	divergence	NN
cord-000248-zueoyesj	1001	9	between	between	IN
cord-000248-zueoyesj	1001	10	two	two	CD
cord-000248-zueoyesj	1001	11	probability	probability	NN
cord-000248-zueoyesj	1001	12	density	density	NN
cord-000248-zueoyesj	1001	13	functions	function	NNS
cord-000248-zueoyesj	1001	14	P	p	NN
cord-000248-zueoyesj	1001	15	(	(	-LRB-
cord-000248-zueoyesj	1001	16	1	1	CD
cord-000248-zueoyesj	1001	17	)	)	-RRB-
cord-000248-zueoyesj	1001	18	and	and	CC
cord-000248-zueoyesj	1001	19	P	p	NN
cord-000248-zueoyesj	1001	20	(	(	-LRB-
cord-000248-zueoyesj	1001	21	2	2	CD
cord-000248-zueoyesj	1001	22	)	)	-RRB-
cord-000248-zueoyesj	1001	23	,	,	,
cord-000248-zueoyesj	1001	24	which	which	WDT
cord-000248-zueoyesj	1001	25	in	in	IN
cord-000248-zueoyesj	1001	26	turn	turn	NN
cord-000248-zueoyesj	1001	27	is	be	VBZ
cord-000248-zueoyesj	1001	28	defined	define	VBN
cord-000248-zueoyesj	1001	29	as	as	IN
cord-000248-zueoyesj	1001	30	J	J	NNP
cord-000248-zueoyesj	1001	31	s	s	NNP
cord-000248-zueoyesj	1001	32	P	P	NNP
cord-000248-zueoyesj	1001	33	(	(	-LRB-
cord-000248-zueoyesj	1001	34	1	1	CD
cord-000248-zueoyesj	1001	35	)	)	-RRB-
cord-000248-zueoyesj	1001	36	,	,	,
cord-000248-zueoyesj	1001	37	P	p	NN
cord-000248-zueoyesj	1001	38	(	(	-LRB-
cord-000248-zueoyesj	1001	39	2	2	CD
cord-000248-zueoyesj	1001	40	)	)	-RRB-
cord-000248-zueoyesj	1002	1	Â	â	NN
cord-000248-zueoyesj	1002	2	Ã	ã	NN
cord-000248-zueoyesj	1002	3	H	h	NN
cord-000248-zueoyesj	1002	4	P	p	NN
cord-000248-zueoyesj	1002	5	(	(	-LRB-
cord-000248-zueoyesj	1002	6	1	1	CD
cord-000248-zueoyesj	1002	7	)	)	-RRB-
cord-000248-zueoyesj	1003	1	zP	zp	XX
cord-000248-zueoyesj	1004	1	(	(	-LRB-
cord-000248-zueoyesj	1004	2	2	2	LS
cord-000248-zueoyesj	1004	3	)	)	-RRB-
cord-000248-zueoyesj	1004	4	2	2	CD
cord-000248-zueoyesj	1005	1	In	in	IN
cord-000248-zueoyesj	1005	2	this	this	DT
cord-000248-zueoyesj	1005	3	work	work	NN
cord-000248-zueoyesj	1005	4	,	,	,
cord-000248-zueoyesj	1005	5	in	in	IN
cord-000248-zueoyesj	1005	6	many	many	JJ
cord-000248-zueoyesj	1005	7	cases	case	NNS
cord-000248-zueoyesj	1005	8	we	-PRON-	PRP
cord-000248-zueoyesj	1005	9	compute	compute	VBP
cord-000248-zueoyesj	1005	10	the	the	DT
cord-000248-zueoyesj	1005	11	Jensen	Jensen	NNP
cord-000248-zueoyesj	1005	12	-	-	HYPH
cord-000248-zueoyesj	1005	13	Shannon	Shannon	NNP
cord-000248-zueoyesj	1005	14	divergences	divergence	NNS
cord-000248-zueoyesj	1005	15	of	of	IN
cord-000248-zueoyesj	1005	16	a	a	DT
cord-000248-zueoyesj	1005	17	probability	probability	NN
cord-000248-zueoyesj	1005	18	with	with	IN
cord-000248-zueoyesj	1005	19	a	a	DT
cord-000248-zueoyesj	1005	20	probability	probability	NN
cord-000248-zueoyesj	1005	21	of	of	IN
cord-000248-zueoyesj	1005	22	reference	reference	NN
cord-000248-zueoyesj	1005	23	which	which	WDT
cord-000248-zueoyesj	1005	24	is	be	VBZ
cord-000248-zueoyesj	1005	25	not	not	RB
cord-000248-zueoyesj	1005	26	the	the	DT
cord-000248-zueoyesj	1005	27	uniform	uniform	JJ
cord-000248-zueoyesj	1005	28	probability	probability	NN
cord-000248-zueoyesj	1005	29	distribution	distribution	NN
cord-000248-zueoyesj	1005	30	over	over	IN
cord-000248-zueoyesj	1005	31	the	the	DT
cord-000248-zueoyesj	1005	32	ensemble	ensemble	NN
cord-000248-zueoyesj	1005	33	.	.	.
cord-000248-zueoyesj	1006	1	In	in	IN
cord-000248-zueoyesj	1006	2	general	general	JJ
cord-000248-zueoyesj	1006	3	,	,	,
cord-000248-zueoyesj	1006	4	it	-PRON-	PRP
cord-000248-zueoyesj	1006	5	is	be	VBZ
cord-000248-zueoyesj	1006	6	the	the	DT
cord-000248-zueoyesj	1006	7	average	average	NN
cord-000248-zueoyesj	1006	8	over	over	IN
cord-000248-zueoyesj	1006	9	a	a	DT
cord-000248-zueoyesj	1006	10	subset	subset	NN
cord-000248-zueoyesj	1006	11	of	of	IN
cord-000248-zueoyesj	1006	12	probability	probability	NN
cord-000248-zueoyesj	1006	13	distribution	distribution	NN
cord-000248-zueoyesj	1006	14	functions	function	NNS
cord-000248-zueoyesj	1006	15	which	which	WDT
cord-000248-zueoyesj	1006	16	are	be	VBP
cord-000248-zueoyesj	1006	17	consider	consider	JJ
cord-000248-zueoyesj	1006	18	to	to	TO
cord-000248-zueoyesj	1006	19	be	be	VB
cord-000248-zueoyesj	1006	20	either	either	CC
cord-000248-zueoyesj	1006	21	the	the	DT
cord-000248-zueoyesj	1006	22	'	'	``
cord-000248-zueoyesj	1006	23	'	'	``
cord-000248-zueoyesj	1006	24	initial	initial	NN
cord-000248-zueoyesj	1006	25	'	'	''
cord-000248-zueoyesj	1006	26	'	'	''
cord-000248-zueoyesj	1006	27	of	of	IN
cord-000248-zueoyesj	1006	28	'	'	''
cord-000248-zueoyesj	1006	29	'	'	``
cord-000248-zueoyesj	1006	30	final	final	JJ
cord-000248-zueoyesj	1006	31	'	'	''
cord-000248-zueoyesj	1006	32	'	'	''
cord-000248-zueoyesj	1006	33	states	state	NNS
cord-000248-zueoyesj	1006	34	of	of	IN
cord-000248-zueoyesj	1006	35	interest	interest	NN
cord-000248-zueoyesj	1006	36	.	.	.
cord-000248-zueoyesj	1007	1	Let	let	VB
cord-000248-zueoyesj	1007	2	P	p	NN
cord-000248-zueoyesj	1007	3	ave	ave	NNP
cord-000248-zueoyesj	1007	4	be	be	VB
cord-000248-zueoyesj	1007	5	such	such	PDT
cord-000248-zueoyesj	1007	6	an	an	DT
cord-000248-zueoyesj	1007	7	average	average	NN
cord-000248-zueoyesj	1007	8	,	,	,
cord-000248-zueoyesj	1007	9	then	then	RB
cord-000248-zueoyesj	1007	10	the	the	DT
cord-000248-zueoyesj	1007	11	M	M	NNP
cord-000248-zueoyesj	1007	12	-	-	HYPH
cord-000248-zueoyesj	1007	13	Statistical	Statistical	NNP
cord-000248-zueoyesj	1007	14	Complexity	Complexity	NNP
cord-000248-zueoyesj	1007	15	of	of	IN
cord-000248-zueoyesj	1007	16	a	a	DT
cord-000248-zueoyesj	1007	17	probability	probability	NN
cord-000248-zueoyesj	1007	18	distribution	distribution	NN
cord-000248-zueoyesj	1007	19	function	function	NN
cord-000248-zueoyesj	1007	20	P	p	NN
cord-000248-zueoyesj	1007	21	(	(	-LRB-
cord-000248-zueoyesj	1007	22	j	j	NNP
cord-000248-zueoyesj	1007	23	)	)	-RRB-
cord-000248-zueoyesj	1007	24	,	,	,
cord-000248-zueoyesj	1007	25	given	give	VBN
cord-000248-zueoyesj	1007	26	a	a	DT
cord-000248-zueoyesj	1007	27	P	P	NNP
cord-000248-zueoyesj	1007	28	ave	ave	NNP
cord-000248-zueoyesj	1007	29	of	of	IN
cord-000248-zueoyesj	1007	30	reference	reference	NN
cord-000248-zueoyesj	1007	31	,	,	,
cord-000248-zueoyesj	1007	32	is	be	VBZ
cord-000248-zueoyesj	1007	33	given	give	VBN
cord-000248-zueoyesj	1007	34	by	by	IN
cord-000248-zueoyesj	1007	35	C	C	NNP
cord-000248-zueoyesj	1007	36	(	(	-LRB-
cord-000248-zueoyesj	1007	37	M	M	NNP
cord-000248-zueoyesj	1007	38	)	)	-RRB-
cord-000248-zueoyesj	1007	39	P	P	NNP
cord-000248-zueoyesj	1007	40	(	(	-LRB-
cord-000248-zueoyesj	1007	41	j	j	NNP
cord-000248-zueoyesj	1007	42	)	)	-RRB-
cord-000248-zueoyesj	1007	43	Â	â	NN
cord-000248-zueoyesj	1007	44	Ã	ã	NN
cord-000248-zueoyesj	1008	1	~H	~H	NFP
cord-000248-zueoyesj	1008	2	P	p	NN
cord-000248-zueoyesj	1008	3	(	(	-LRB-
cord-000248-zueoyesj	1008	4	j	j	NNP
cord-000248-zueoyesj	1008	5	)	)	-RRB-
cord-000248-zueoyesj	1008	6	Â	â	NN
cord-000248-zueoyesj	1008	7	Ã	Ã	NNP
cord-000248-zueoyesj	1008	8	:	:	:
cord-000248-zueoyesj	1008	9	J	J	NNP
cord-000248-zueoyesj	1008	10	s	s	NNP
cord-000248-zueoyesj	1008	11	P	P	NNP
cord-000248-zueoyesj	1008	12	(	(	-LRB-
cord-000248-zueoyesj	1008	13	j	j	NNP
cord-000248-zueoyesj	1008	14	)	)	-RRB-
cord-000248-zueoyesj	1008	15	,	,	,
cord-000248-zueoyesj	1008	16	P	P	NNP
cord-000248-zueoyesj	1008	17	ave	ave	NNP
cord-000248-zueoyesj	1008	18	Â	Â	NNP
cord-000248-zueoyesj	1008	19	Ã	Ã	NNP
cord-000248-zueoyesj	1009	1	An	an	DT
cord-000248-zueoyesj	1009	2	illutrative	illutrative	JJ
cord-000248-zueoyesj	1009	3	example	example	NN
cord-000248-zueoyesj	1009	4	.	.	.
cord-000248-zueoyesj	1010	1	In	in	IN
cord-000248-zueoyesj	1010	2	order	order	NN
cord-000248-zueoyesj	1010	3	to	to	TO
cord-000248-zueoyesj	1010	4	discuss	discuss	VB
cord-000248-zueoyesj	1010	5	a	a	DT
cord-000248-zueoyesj	1010	6	relatively	relatively	RB
cord-000248-zueoyesj	1010	7	simple	simple	JJ
cord-000248-zueoyesj	1010	8	example	example	NN
cord-000248-zueoyesj	1010	9	that	that	WDT
cord-000248-zueoyesj	1010	10	can	can	MD
cord-000248-zueoyesj	1010	11	intuitively	intuitively	RB
cord-000248-zueoyesj	1010	12	provide	provide	VB
cord-000248-zueoyesj	1010	13	a	a	DT
cord-000248-zueoyesj	1010	14	grasp	grasp	NN
cord-000248-zueoyesj	1010	15	of	of	IN
cord-000248-zueoyesj	1010	16	the	the	DT
cord-000248-zueoyesj	1010	17	basic	basic	JJ
cord-000248-zueoyesj	1010	18	mathematical	mathematical	JJ
cord-000248-zueoyesj	1010	19	principles	principle	NNS
cord-000248-zueoyesj	1010	20	of	of	IN
cord-000248-zueoyesj	1010	21	Information	information	NN
cord-000248-zueoyesj	1010	22	Theory	Theory	NNP
cord-000248-zueoyesj	1010	23	we	-PRON-	PRP
cord-000248-zueoyesj	1010	24	present	present	VBP
cord-000248-zueoyesj	1010	25	a	a	DT
cord-000248-zueoyesj	1010	26	hypothetical	hypothetical	JJ
cord-000248-zueoyesj	1010	27	'	'	''
cord-000248-zueoyesj	1010	28	'	'	''
cord-000248-zueoyesj	1010	29	gene	gene	NN
cord-000248-zueoyesj	1010	30	expression	expression	NN
cord-000248-zueoyesj	1010	31	'	'	''
cord-000248-zueoyesj	1010	32	'	'	''
cord-000248-zueoyesj	1010	33	dataset	dataset	NN
cord-000248-zueoyesj	1010	34	involving	involve	VBG
cord-000248-zueoyesj	1010	35	four	four	CD
cord-000248-zueoyesj	1010	36	samples	sample	NNS
cord-000248-zueoyesj	1010	37	each	each	DT
cord-000248-zueoyesj	1010	38	with	with	IN
cord-000248-zueoyesj	1010	39	the	the	DT
cord-000248-zueoyesj	1010	40	expression	expression	NN
cord-000248-zueoyesj	1010	41	of	of	IN
cord-000248-zueoyesj	1010	42	five	five	CD
cord-000248-zueoyesj	1010	43	unique	unique	JJ
cord-000248-zueoyesj	1010	44	probes	probe	NNS
cord-000248-zueoyesj	1010	45	corresponding	correspond	VBG
cord-000248-zueoyesj	1010	46	to	to	IN
cord-000248-zueoyesj	1010	47	five	five	CD
cord-000248-zueoyesj	1010	48	genes	gene	NNS
cord-000248-zueoyesj	1010	49	(	(	-LRB-
cord-000248-zueoyesj	1010	50	not	not	RB
cord-000248-zueoyesj	1010	51	necessarily	necessarily	RB
cord-000248-zueoyesj	1010	52	different	different	JJ
cord-000248-zueoyesj	1010	53	)	)	-RRB-
cord-000248-zueoyesj	1010	54	as	as	IN
cord-000248-zueoyesj	1010	55	follows	follow	VBZ
cord-000248-zueoyesj	1010	56	in	in	IN
cord-000248-zueoyesj	1010	57	Table	Table	NNP
cord-000248-zueoyesj	1010	58	3	3	CD
cord-000248-zueoyesj	1010	59	.	.	.
cord-000248-zueoyesj	1011	1	One	one	CD
cord-000248-zueoyesj	1011	2	of	of	IN
cord-000248-zueoyesj	1011	3	the	the	DT
cord-000248-zueoyesj	1011	4	quantifiers	quantifier	NNS
cord-000248-zueoyesj	1011	5	that	that	WDT
cord-000248-zueoyesj	1011	6	we	-PRON-	PRP
cord-000248-zueoyesj	1011	7	use	use	VBP
cord-000248-zueoyesj	1011	8	in	in	IN
cord-000248-zueoyesj	1011	9	this	this	DT
cord-000248-zueoyesj	1011	10	contribution	contribution	NN
cord-000248-zueoyesj	1011	11	describes	describe	VBZ
cord-000248-zueoyesj	1011	12	a	a	DT
cord-000248-zueoyesj	1011	13	measure	measure	NN
cord-000248-zueoyesj	1011	14	of	of	IN
cord-000248-zueoyesj	1011	15	order	order	NN
cord-000248-zueoyesj	1011	16	for	for	IN
cord-000248-zueoyesj	1011	17	a	a	DT
cord-000248-zueoyesj	1011	18	sample	sample	NN
cord-000248-zueoyesj	1011	19	:	:	:
cord-000248-zueoyesj	1011	20	the	the	DT
cord-000248-zueoyesj	1011	21	Normalized	Normalized	NNP
cord-000248-zueoyesj	1011	22	Shannon	Shannon	NNP
cord-000248-zueoyesj	1011	23	Entropy	Entropy	NNP
cord-000248-zueoyesj	1011	24	also	also	RB
cord-000248-zueoyesj	1011	25	known	know	VBN
cord-000248-zueoyesj	1011	26	as	as	IN
cord-000248-zueoyesj	1011	27	Shannon	Shannon	NNP
cord-000248-zueoyesj	1011	28	Evenness	Evenness	NNP
cord-000248-zueoyesj	1011	29	Index	Index	NNP
cord-000248-zueoyesj	1011	30	[	[	-LRB-
cord-000248-zueoyesj	1011	31	803	803	CD
cord-000248-zueoyesj	1011	32	]	]	-RRB-
cord-000248-zueoyesj	1011	33	.	.	.
cord-000248-zueoyesj	1012	1	This	this	DT
cord-000248-zueoyesj	1012	2	section	section	NN
cord-000248-zueoyesj	1012	3	focuses	focus	VBZ
cord-000248-zueoyesj	1012	4	on	on	IN
cord-000248-zueoyesj	1012	5	this	this	DT
cord-000248-zueoyesj	1012	6	quantifiers	quantifier	NNS
cord-000248-zueoyesj	1012	7	use	use	VBP
cord-000248-zueoyesj	1012	8	and	and	CC
cord-000248-zueoyesj	1012	9	importance	importance	NN
cord-000248-zueoyesj	1012	10	(	(	-LRB-
cord-000248-zueoyesj	1012	11	refer	refer	VB
cord-000248-zueoyesj	1012	12	to	to	IN
cord-000248-zueoyesj	1012	13	the	the	DT
cord-000248-zueoyesj	1012	14	'	'	``
cord-000248-zueoyesj	1012	15	Materials	material	NNS
cord-000248-zueoyesj	1012	16	and	and	CC
cord-000248-zueoyesj	1012	17	Methods	Methods	NNPS
cord-000248-zueoyesj	1012	18	'	'	POS
cord-000248-zueoyesj	1012	19	section	section	NN
cord-000248-zueoyesj	1012	20	to	to	TO
cord-000248-zueoyesj	1012	21	see	see	VB
cord-000248-zueoyesj	1012	22	how	how	WRB
cord-000248-zueoyesj	1012	23	this	this	DT
cord-000248-zueoyesj	1012	24	measure	measure	NN
cord-000248-zueoyesj	1012	25	is	be	VBZ
cord-000248-zueoyesj	1012	26	calculated	calculate	VBN
cord-000248-zueoyesj	1012	27	)	)	-RRB-
cord-000248-zueoyesj	1012	28	.	.	.
cord-000248-zueoyesj	1013	1	In	in	IN
cord-000248-zueoyesj	1013	2	Sample	Sample	NNP
cord-000248-zueoyesj	1013	3	4	4	CD
cord-000248-zueoyesj	1013	4	all	all	DT
cord-000248-zueoyesj	1013	5	probes	probe	NNS
cord-000248-zueoyesj	1013	6	have	have	VBP
cord-000248-zueoyesj	1013	7	the	the	DT
cord-000248-zueoyesj	1013	8	same	same	JJ
cord-000248-zueoyesj	1013	9	expression	expression	NN
cord-000248-zueoyesj	1013	10	therefore	therefore	RB
cord-000248-zueoyesj	1013	11	it	-PRON-	PRP
cord-000248-zueoyesj	1013	12	has	have	VBZ
cord-000248-zueoyesj	1013	13	the	the	DT
cord-000248-zueoyesj	1013	14	highest	high	JJS
cord-000248-zueoyesj	1013	15	achievable	achievable	JJ
cord-000248-zueoyesj	1013	16	value	value	NN
cord-000248-zueoyesj	1013	17	of	of	IN
cord-000248-zueoyesj	1013	18	Normalized	Normalized	NNP
cord-000248-zueoyesj	1013	19	Shannon	Shannon	NNP
cord-000248-zueoyesj	1013	20	Entropy	Entropy	NNP
cord-000248-zueoyesj	1013	21	(	(	-LRB-
cord-000248-zueoyesj	1013	22	H	h	NN
cord-000248-zueoyesj	1013	23	=	=	SYM
cord-000248-zueoyesj	1013	24	1	1	CD
cord-000248-zueoyesj	1013	25	)	)	-RRB-
cord-000248-zueoyesj	1013	26	.	.	.
cord-000248-zueoyesj	1014	1	The	the	DT
cord-000248-zueoyesj	1014	2	Normalized	Normalized	NNP
cord-000248-zueoyesj	1014	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	1014	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	1014	5	values	value	NNS
cord-000248-zueoyesj	1014	6	for	for	IN
cord-000248-zueoyesj	1014	7	samples	sample	NNS
cord-000248-zueoyesj	1014	8	1	1	CD
cord-000248-zueoyesj	1014	9	and	and	CC
cord-000248-zueoyesj	1014	10	2	2	CD
cord-000248-zueoyesj	1014	11	are	be	VBP
cord-000248-zueoyesj	1014	12	the	the	DT
cord-000248-zueoyesj	1014	13	same	same	JJ
cord-000248-zueoyesj	1014	14	(	(	-LRB-
cord-000248-zueoyesj	1014	15	H	h	NN
cord-000248-zueoyesj	1014	16	=	=	SYM
cord-000248-zueoyesj	1014	17	0.82	0.82	CD
cord-000248-zueoyesj	1014	18	)	)	-RRB-
cord-000248-zueoyesj	1014	19	.	.	.
cord-000248-zueoyesj	1015	1	Sample	sample	NN
cord-000248-zueoyesj	1015	2	3	3	CD
cord-000248-zueoyesj	1015	3	,	,	,
cord-000248-zueoyesj	1015	4	which	which	WDT
cord-000248-zueoyesj	1015	5	tends	tend	VBZ
cord-000248-zueoyesj	1015	6	to	to	TO
cord-000248-zueoyesj	1015	7	be	be	VB
cord-000248-zueoyesj	1015	8	less	less	RBR
cord-000248-zueoyesj	1015	9	peaked	peaked	JJ
cord-000248-zueoyesj	1015	10	and	and	CC
cord-000248-zueoyesj	1015	11	has	have	VBZ
cord-000248-zueoyesj	1015	12	the	the	DT
cord-000248-zueoyesj	1015	13	two	two	CD
cord-000248-zueoyesj	1015	14	most	most	RBS
cord-000248-zueoyesj	1015	15	significantly	significantly	RB
cord-000248-zueoyesj	1015	16	expressed	express	VBD
cord-000248-zueoyesj	1015	17	genes	gene	NNS
cord-000248-zueoyesj	1015	18	with	with	IN
cord-000248-zueoyesj	1015	19	the	the	DT
cord-000248-zueoyesj	1015	20	same	same	JJ
cord-000248-zueoyesj	1015	21	value	value	NN
cord-000248-zueoyesj	1015	22	,	,	,
cord-000248-zueoyesj	1015	23	has	have	VBZ
cord-000248-zueoyesj	1015	24	a	a	DT
cord-000248-zueoyesj	1015	25	higher	high	JJR
cord-000248-zueoyesj	1015	26	value	value	NN
cord-000248-zueoyesj	1015	27	of	of	IN
cord-000248-zueoyesj	1015	28	Normalized	Normalized	NNP
cord-000248-zueoyesj	1015	29	Shannon	Shannon	NNP
cord-000248-zueoyesj	1015	30	Entropy	Entropy	NNP
cord-000248-zueoyesj	1015	31	(	(	-LRB-
cord-000248-zueoyesj	1015	32	H	h	NN
cord-000248-zueoyesj	1015	33	=	=	SYM
cord-000248-zueoyesj	1015	34	0.92	0.92	CD
cord-000248-zueoyesj	1015	35	)	)	-RRB-
cord-000248-zueoyesj	1015	36	(	(	-LRB-
cord-000248-zueoyesj	1015	37	see	see	VB
cord-000248-zueoyesj	1015	38	Figure	Figure	NNP
cord-000248-zueoyesj	1015	39	21	21	CD
cord-000248-zueoyesj	1015	40	)	)	-RRB-
cord-000248-zueoyesj	1015	41	.	.	.
cord-000248-zueoyesj	1016	1	This	this	DT
cord-000248-zueoyesj	1016	2	simple	simple	JJ
cord-000248-zueoyesj	1016	3	example	example	NN
cord-000248-zueoyesj	1016	4	shows	show	VBZ
cord-000248-zueoyesj	1016	5	that	that	IN
cord-000248-zueoyesj	1016	6	the	the	DT
cord-000248-zueoyesj	1016	7	Normalized	Normalized	NNP
cord-000248-zueoyesj	1016	8	Shannon	Shannon	NNP
cord-000248-zueoyesj	1016	9	Entropy	Entropy	NNP
cord-000248-zueoyesj	1016	10	variations	variation	NNS
cord-000248-zueoyesj	1016	11	of	of	IN
cord-000248-zueoyesj	1016	12	the	the	DT
cord-000248-zueoyesj	1016	13	gene	gene	NN
cord-000248-zueoyesj	1016	14	expression	expression	NN
cord-000248-zueoyesj	1016	15	profile	profile	NN
cord-000248-zueoyesj	1016	16	convey	convey	VB
cord-000248-zueoyesj	1016	17	information	information	NN
cord-000248-zueoyesj	1016	18	about	about	IN
cord-000248-zueoyesj	1016	19	global	global	JJ
cord-000248-zueoyesj	1016	20	transcriptomic	transcriptomic	JJ
cord-000248-zueoyesj	1016	21	changes	change	NNS
cord-000248-zueoyesj	1016	22	;	;	:
cord-000248-zueoyesj	1016	23	however	however	RB
cord-000248-zueoyesj	1016	24	,	,	,
cord-000248-zueoyesj	1016	25	this	this	DT
cord-000248-zueoyesj	1016	26	measure	measure	NN
cord-000248-zueoyesj	1016	27	alone	alone	RB
cord-000248-zueoyesj	1016	28	is	be	VBZ
cord-000248-zueoyesj	1016	29	not	not	RB
cord-000248-zueoyesj	1016	30	enough	enough	JJ
cord-000248-zueoyesj	1016	31	to	to	TO
cord-000248-zueoyesj	1016	32	characterize	characterize	VB
cord-000248-zueoyesj	1016	33	the	the	DT
cord-000248-zueoyesj	1016	34	deviations	deviation	NNS
cord-000248-zueoyesj	1016	35	from	from	IN
cord-000248-zueoyesj	1016	36	normal	normal	JJ
cord-000248-zueoyesj	1016	37	tissue	tissue	NN
cord-000248-zueoyesj	1016	38	profiles	profile	NNS
cord-000248-zueoyesj	1016	39	.	.	.
cord-000248-zueoyesj	1017	1	For	for	IN
cord-000248-zueoyesj	1017	2	example	example	NN
cord-000248-zueoyesj	1017	3	,	,	,
cord-000248-zueoyesj	1017	4	assume	assume	VBP
cord-000248-zueoyesj	1017	5	that	that	IN
cord-000248-zueoyesj	1017	6	Sample	Sample	NNP
cord-000248-zueoyesj	1017	7	1	1	CD
cord-000248-zueoyesj	1017	8	is	be	VBZ
cord-000248-zueoyesj	1017	9	the	the	DT
cord-000248-zueoyesj	1017	10	normal	normal	JJ
cord-000248-zueoyesj	1017	11	profile	profile	NN
cord-000248-zueoyesj	1017	12	of	of	IN
cord-000248-zueoyesj	1017	13	a	a	DT
cord-000248-zueoyesj	1017	14	particular	particular	JJ
cord-000248-zueoyesj	1017	15	tissue	tissue	NN
cord-000248-zueoyesj	1017	16	type	type	NN
cord-000248-zueoyesj	1017	17	.	.	.
cord-000248-zueoyesj	1018	1	Assume	assume	VB
cord-000248-zueoyesj	1018	2	that	that	IN
cord-000248-zueoyesj	1018	3	Sample	Sample	NNP
cord-000248-zueoyesj	1018	4	3	3	CD
cord-000248-zueoyesj	1018	5	is	be	VBZ
cord-000248-zueoyesj	1018	6	the	the	DT
cord-000248-zueoyesj	1018	7	profile	profile	NN
cord-000248-zueoyesj	1018	8	of	of	IN
cord-000248-zueoyesj	1018	9	a	a	DT
cord-000248-zueoyesj	1018	10	cancer	cancer	NN
cord-000248-zueoyesj	1018	11	cell	cell	NN
cord-000248-zueoyesj	1018	12	that	that	WDT
cord-000248-zueoyesj	1018	13	originated	originate	VBD
cord-000248-zueoyesj	1018	14	from	from	IN
cord-000248-zueoyesj	1018	15	that	that	DT
cord-000248-zueoyesj	1018	16	tissue	tissue	NN
cord-000248-zueoyesj	1018	17	type	type	NN
cord-000248-zueoyesj	1018	18	,	,	,
cord-000248-zueoyesj	1018	19	the	the	DT
cord-000248-zueoyesj	1018	20	variation	variation	NN
cord-000248-zueoyesj	1018	21	of	of	IN
cord-000248-zueoyesj	1018	22	Normalized	Normalized	NNP
cord-000248-zueoyesj	1018	23	Shannon	Shannon	NNP
cord-000248-zueoyesj	1018	24	Entropy	Entropy	NNP
cord-000248-zueoyesj	1018	25	can	can	MD
cord-000248-zueoyesj	1018	26	be	be	VB
cord-000248-zueoyesj	1018	27	related	relate	VBN
cord-000248-zueoyesj	1018	28	to	to	IN
cord-000248-zueoyesj	1018	29	this	this	DT
cord-000248-zueoyesj	1018	30	malignant	malignant	JJ
cord-000248-zueoyesj	1018	31	change	change	NN
cord-000248-zueoyesj	1018	32	.	.	.
cord-000248-zueoyesj	1019	1	However	however	RB
cord-000248-zueoyesj	1019	2	,	,	,
cord-000248-zueoyesj	1019	3	as	as	IN
cord-000248-zueoyesj	1019	4	Sample	sample	NN
cord-000248-zueoyesj	1019	5	2	2	CD
cord-000248-zueoyesj	1019	6	illustrates	illustrate	NNS
cord-000248-zueoyesj	1019	7	,	,	,
cord-000248-zueoyesj	1019	8	Normalized	Normalized	NNP
cord-000248-zueoyesj	1019	9	Shannon	Shannon	NNP
cord-000248-zueoyesj	1019	10	Entropy	Entropy	NNP
cord-000248-zueoyesj	1019	11	is	be	VBZ
cord-000248-zueoyesj	1019	12	not	not	RB
cord-000248-zueoyesj	1019	13	enough	enough	JJ
cord-000248-zueoyesj	1019	14	to	to	TO
cord-000248-zueoyesj	1019	15	let	let	VB
cord-000248-zueoyesj	1019	16	us	-PRON-	PRP
cord-000248-zueoyesj	1019	17	to	to	TO
cord-000248-zueoyesj	1019	18	measure	measure	VB
cord-000248-zueoyesj	1019	19	the	the	DT
cord-000248-zueoyesj	1019	20	variation	variation	NN
cord-000248-zueoyesj	1019	21	from	from	IN
cord-000248-zueoyesj	1019	22	a	a	DT
cord-000248-zueoyesj	1019	23	profile	profile	NN
cord-000248-zueoyesj	1019	24	and	and	CC
cord-000248-zueoyesj	1019	25	at	at	IN
cord-000248-zueoyesj	1019	26	least	least	JJS
cord-000248-zueoyesj	1019	27	another	another	DT
cord-000248-zueoyesj	1019	28	Information	information	NN
cord-000248-zueoyesj	1019	29	Theory	Theory	NNP
cord-000248-zueoyesj	1019	30	quantifier	quantifier	NN
cord-000248-zueoyesj	1019	31	is	be	VBZ
cord-000248-zueoyesj	1019	32	needed	need	VBN
cord-000248-zueoyesj	1019	33	.	.	.
cord-000248-zueoyesj	1020	1	We	-PRON-	PRP
cord-000248-zueoyesj	1020	2	resort	resort	VBP
cord-000248-zueoyesj	1020	3	to	to	IN
cord-000248-zueoyesj	1020	4	Statistical	Statistical	NNP
cord-000248-zueoyesj	1020	5	Complexity	Complexity	NNP
cord-000248-zueoyesj	1020	6	quantifiers	quantifier	NNS
cord-000248-zueoyesj	1020	7	,	,	,
cord-000248-zueoyesj	1020	8	which	which	WDT
cord-000248-zueoyesj	1020	9	in	in	IN
cord-000248-zueoyesj	1020	10	turn	turn	NN
cord-000248-zueoyesj	1020	11	use	use	VBP
cord-000248-zueoyesj	1020	12	the	the	DT
cord-000248-zueoyesj	1020	13	Jensen	Jensen	NNP
cord-000248-zueoyesj	1020	14	-	-	HYPH
cord-000248-zueoyesj	1020	15	Shannon	Shannon	NNP
cord-000248-zueoyesj	1020	16	divergence	divergence	NN
cord-000248-zueoyesj	1020	17	[	[	-LRB-
cord-000248-zueoyesj	1020	18	798	798	CD
cord-000248-zueoyesj	1020	19	]	]	-RRB-
cord-000248-zueoyesj	1020	20	to	to	TO
cord-000248-zueoyesj	1020	21	provide	provide	VB
cord-000248-zueoyesj	1020	22	this	this	DT
cord-000248-zueoyesj	1020	23	complementary	complementary	JJ
cord-000248-zueoyesj	1020	24	dimension	dimension	NN
cord-000248-zueoyesj	1020	25	[	[	-LRB-
cord-000248-zueoyesj	1020	26	800	800	CD
cord-000248-zueoyesj	1020	27	]	]	-RRB-
cord-000248-zueoyesj	1021	1	(	(	-LRB-
cord-000248-zueoyesj	1021	2	refer	refer	VB
cord-000248-zueoyesj	1021	3	to	to	IN
cord-000248-zueoyesj	1021	4	the	the	DT
cord-000248-zueoyesj	1021	5	'	'	``
cord-000248-zueoyesj	1021	6	Materials	material	NNS
cord-000248-zueoyesj	1021	7	and	and	CC
cord-000248-zueoyesj	1021	8	Methods	Methods	NNPS
cord-000248-zueoyesj	1021	9	'	'	POS
cord-000248-zueoyesj	1021	10	section	section	NN
cord-000248-zueoyesj	1021	11	for	for	IN
cord-000248-zueoyesj	1021	12	a	a	DT
cord-000248-zueoyesj	1021	13	mathematical	mathematical	JJ
cord-000248-zueoyesj	1021	14	definition	definition	NN
cord-000248-zueoyesj	1021	15	of	of	IN
cord-000248-zueoyesj	1021	16	the	the	DT
cord-000248-zueoyesj	1021	17	Jensen	Jensen	NNP
cord-000248-zueoyesj	1021	18	-	-	HYPH
cord-000248-zueoyesj	1021	19	Shannon	Shannon	NNP
cord-000248-zueoyesj	1021	20	divergence	divergence	NN
cord-000248-zueoyesj	1021	21	)	)	-RRB-
cord-000248-zueoyesj	1021	22	.	.	.
cord-000248-zueoyesj	1022	1	Figure	figure	NN
cord-000248-zueoyesj	1022	2	21	21	CD
cord-000248-zueoyesj	1022	3	shows	show	NNS
cord-000248-zueoyesj	1022	4	how	how	WRB
cord-000248-zueoyesj	1022	5	the	the	DT
cord-000248-zueoyesj	1022	6	Jensen	Jensen	NNP
cord-000248-zueoyesj	1022	7	-	-	HYPH
cord-000248-zueoyesj	1022	8	Shannon	Shannon	NNP
cord-000248-zueoyesj	1022	9	divergence	divergence	NN
cord-000248-zueoyesj	1022	10	helps	help	VBZ
cord-000248-zueoyesj	1022	11	us	-PRON-	PRP
cord-000248-zueoyesj	1022	12	to	to	TO
cord-000248-zueoyesj	1022	13	evaluate	evaluate	VB
cord-000248-zueoyesj	1022	14	the	the	DT
cord-000248-zueoyesj	1022	15	variation	variation	NN
cord-000248-zueoyesj	1022	16	between	between	IN
cord-000248-zueoyesj	1022	17	profiles	profile	NNS
cord-000248-zueoyesj	1022	18	.	.	.
cord-000248-zueoyesj	1023	1	Samples	sample	NNS
cord-000248-zueoyesj	1023	2	1	1	CD
cord-000248-zueoyesj	1023	3	and	and	CC
cord-000248-zueoyesj	1023	4	2	2	CD
cord-000248-zueoyesj	1023	5	,	,	,
cord-000248-zueoyesj	1023	6	as	as	IN
cord-000248-zueoyesj	1023	7	perhaps	perhaps	RB
cord-000248-zueoyesj	1023	8	intuitively	intuitively	RB
cord-000248-zueoyesj	1023	9	expected	expect	VBN
cord-000248-zueoyesj	1023	10	,	,	,
cord-000248-zueoyesj	1023	11	have	have	VBP
cord-000248-zueoyesj	1023	12	the	the	DT
cord-000248-zueoyesj	1023	13	largest	large	JJS
cord-000248-zueoyesj	1023	14	divergence	divergence	NN
cord-000248-zueoyesj	1023	15	between	between	IN
cord-000248-zueoyesj	1023	16	them	-PRON-	PRP
cord-000248-zueoyesj	1023	17	,	,	,
cord-000248-zueoyesj	1023	18	their	-PRON-	PRP$
cord-000248-zueoyesj	1023	19	Jensen	Jensen	NNP
cord-000248-zueoyesj	1023	20	Shannon	Shannon	NNP
cord-000248-zueoyesj	1023	21	divergence	divergence	NN
cord-000248-zueoyesj	1023	22	is	be	VBZ
cord-000248-zueoyesj	1023	23	0.286636	0.286636	CD
cord-000248-zueoyesj	1023	24	(	(	-LRB-
cord-000248-zueoyesj	1023	25	JS(1,2	JS(1,2	NNP
cord-000248-zueoyesj	1023	26	)	)	-RRB-
cord-000248-zueoyesj	1023	27	=	=	NFP
cord-000248-zueoyesj	1024	1	Table	table	NN
cord-000248-zueoyesj	1024	2	3	3	CD
cord-000248-zueoyesj	1024	3	.	.	.
cord-000248-zueoyesj	1025	1	An	an	DT
cord-000248-zueoyesj	1025	2	example	example	NN
cord-000248-zueoyesj	1025	3	dataset	dataset	NN
cord-000248-zueoyesj	1025	4	to	to	TO
cord-000248-zueoyesj	1025	5	illustrate	illustrate	VB
cord-000248-zueoyesj	1025	6	the	the	DT
cord-000248-zueoyesj	1025	7	principles	principle	NNS
cord-000248-zueoyesj	1025	8	of	of	IN
cord-000248-zueoyesj	1025	9	Shannon	Shannon	NNP
cord-000248-zueoyesj	1025	10	Entropy	Entropy	NNP
cord-000248-zueoyesj	1025	11	and	and	CC
cord-000248-zueoyesj	1025	12	the	the	DT
cord-000248-zueoyesj	1025	13	Information	Information	NNP
cord-000248-zueoyesj	1025	14	Theory	Theory	NNP
cord-000248-zueoyesj	1025	15	quantifiers	quantifier	NNS
cord-000248-zueoyesj	1025	16	used	use	VBN
cord-000248-zueoyesj	1025	17	in	in	IN
cord-000248-zueoyesj	1025	18	this	this	DT
cord-000248-zueoyesj	1025	19	work	work	NN
cord-000248-zueoyesj	1025	20	.	.	.
cord-000248-zueoyesj	1026	1	Table	table	NN
cord-000248-zueoyesj	1026	2	3	3	CD
cord-000248-zueoyesj	1026	3	.	.	.
cord-000248-zueoyesj	1027	1	Sample	sample	NN
cord-000248-zueoyesj	1027	2	4	4	CD
cord-000248-zueoyesj	1027	3	has	have	VBZ
cord-000248-zueoyesj	1027	4	the	the	DT
cord-000248-zueoyesj	1027	5	largest	large	JJS
cord-000248-zueoyesj	1027	6	attainable	attainable	JJ
cord-000248-zueoyesj	1027	7	value	value	NN
cord-000248-zueoyesj	1027	8	since	since	IN
cord-000248-zueoyesj	1027	9	the	the	DT
cord-000248-zueoyesj	1027	10	expression	expression	NN
cord-000248-zueoyesj	1027	11	of	of	IN
cord-000248-zueoyesj	1027	12	all	all	DT
cord-000248-zueoyesj	1027	13	probes	probe	NNS
cord-000248-zueoyesj	1027	14	is	be	VBZ
cord-000248-zueoyesj	1027	15	the	the	DT
cord-000248-zueoyesj	1027	16	same	same	JJ
cord-000248-zueoyesj	1027	17	.	.	.
cord-000248-zueoyesj	1028	1	Samples	sample	NNS
cord-000248-zueoyesj	1028	2	1	1	CD
cord-000248-zueoyesj	1028	3	and	and	CC
cord-000248-zueoyesj	1028	4	2	2	CD
cord-000248-zueoyesj	1028	5	,	,	,
cord-000248-zueoyesj	1028	6	which	which	WDT
cord-000248-zueoyesj	1028	7	have	have	VBP
cord-000248-zueoyesj	1028	8	the	the	DT
cord-000248-zueoyesj	1028	9	same	same	JJ
cord-000248-zueoyesj	1028	10	set	set	NN
cord-000248-zueoyesj	1028	11	of	of	IN
cord-000248-zueoyesj	1028	12	expression	expression	NN
cord-000248-zueoyesj	1028	13	values	value	NNS
cord-000248-zueoyesj	1028	14	,	,	,
cord-000248-zueoyesj	1028	15	although	although	IN
cord-000248-zueoyesj	1028	16	in	in	IN
cord-000248-zueoyesj	1028	17	different	different	JJ
cord-000248-zueoyesj	1028	18	probes	probe	NNS
cord-000248-zueoyesj	1028	19	,	,	,
cord-000248-zueoyesj	1028	20	have	have	VBP
cord-000248-zueoyesj	1028	21	the	the	DT
cord-000248-zueoyesj	1028	22	same	same	JJ
cord-000248-zueoyesj	1028	23	value	value	NN
cord-000248-zueoyesj	1028	24	of	of	IN
cord-000248-zueoyesj	1028	25	Normalized	Normalized	NNP
cord-000248-zueoyesj	1028	26	Shannon	Shannon	NNP
cord-000248-zueoyesj	1028	27	Entropy	Entropy	NNP
cord-000248-zueoyesj	1028	28	.	.	.
cord-000248-zueoyesj	1029	1	As	as	IN
cord-000248-zueoyesj	1029	2	a	a	DT
cord-000248-zueoyesj	1029	3	consequence	consequence	NN
cord-000248-zueoyesj	1029	4	,	,	,
cord-000248-zueoyesj	1029	5	there	there	EX
cord-000248-zueoyesj	1029	6	is	be	VBZ
cord-000248-zueoyesj	1029	7	a	a	DT
cord-000248-zueoyesj	1029	8	need	need	NN
cord-000248-zueoyesj	1029	9	for	for	IN
cord-000248-zueoyesj	1029	10	another	another	DT
cord-000248-zueoyesj	1029	11	quantifier	quantifier	NN
cord-000248-zueoyesj	1029	12	of	of	IN
cord-000248-zueoyesj	1029	13	gene	gene	NN
cord-000248-zueoyesj	1029	14	expression	expression	NN
cord-000248-zueoyesj	1029	15	to	to	TO
cord-000248-zueoyesj	1029	16	address	address	VB
cord-000248-zueoyesj	1029	17	the	the	DT
cord-000248-zueoyesj	1029	18	permutational	permutational	JJ
cord-000248-zueoyesj	1029	19	indistinguishability	indistinguishability	NN
cord-000248-zueoyesj	1029	20	of	of	IN
cord-000248-zueoyesj	1029	21	these	these	DT
cord-000248-zueoyesj	1029	22	two	two	CD
cord-000248-zueoyesj	1029	23	expression	expression	NN
cord-000248-zueoyesj	1029	24	profiles	profile	NNS
cord-000248-zueoyesj	1029	25	.	.	.
cord-000248-zueoyesj	1030	1	The	the	DT
cord-000248-zueoyesj	1030	2	Jensen	Jensen	NNP
cord-000248-zueoyesj	1030	3	-	-	HYPH
cord-000248-zueoyesj	1030	4	Shannon	Shannon	NNP
cord-000248-zueoyesj	1030	5	divergence	divergence	NN
cord-000248-zueoyesj	1030	6	provides	provide	VBZ
cord-000248-zueoyesj	1030	7	a	a	DT
cord-000248-zueoyesj	1030	8	natural	natural	JJ
cord-000248-zueoyesj	1030	9	alternative	alternative	NN
cord-000248-zueoyesj	1030	10	(	(	-LRB-
cord-000248-zueoyesj	1030	11	see	see	VB
cord-000248-zueoyesj	1030	12	Table	Table	NNP
cord-000248-zueoyesj	1030	13	4	4	CD
cord-000248-zueoyesj	1030	14	)	)	-RRB-
cord-000248-zueoyesj	1030	15	.	.	.
cord-000248-zueoyesj	1031	1	doi:10.1371	doi:10.1371	NNP
cord-000248-zueoyesj	1032	1	/journal.pone.0012262.g021	/journal.pone.0012262.g021	:
cord-000248-zueoyesj	1032	2	Table	table	NN
cord-000248-zueoyesj	1032	3	4	4	CD
cord-000248-zueoyesj	1032	4	.	.	.
cord-000248-zueoyesj	1033	1	Jensen	Jensen	NNP
cord-000248-zueoyesj	1033	2	-	-	HYPH
cord-000248-zueoyesj	1033	3	Shannon	Shannon	NNP
cord-000248-zueoyesj	1033	4	divergence	divergence	NN
cord-000248-zueoyesj	1033	5	values	value	NNS
cord-000248-zueoyesj	1033	6	using	use	VBG
cord-000248-zueoyesj	1033	7	the	the	DT
cord-000248-zueoyesj	1033	8	example	example	NN
cord-000248-zueoyesj	1033	9	introduced	introduce	VBN
cord-000248-zueoyesj	1033	10	in	in	IN
cord-000248-zueoyesj	1033	11	Table	Table	NNP
cord-000248-zueoyesj	1033	12	3	3	CD
cord-000248-zueoyesj	1033	13	.	.	.
cord-000248-zueoyesj	1034	1	Table	table	NN
cord-000248-zueoyesj	1034	2	4	4	CD
cord-000248-zueoyesj	1034	3	.	.	.
cord-000248-zueoyesj	1035	1	Let	let	VB
cord-000248-zueoyesj	1035	2	H	h	NN
cord-000248-zueoyesj	1035	3	P	p	NN
cord-000248-zueoyesj	1035	4	(	(	-LRB-
cord-000248-zueoyesj	1035	5	j	j	NN
cord-000248-zueoyesj	1035	6	)	)	-RRB-
cord-000248-zueoyesj	1036	1	Â	â	NN
cord-000248-zueoyesj	1037	1	Ã	Ã	NNS
cord-000248-zueoyesj	1037	2	be	be	VBP
cord-000248-zueoyesj	1037	3	the	the	DT
cord-000248-zueoyesj	1037	4	Normalized	Normalized	NNP
cord-000248-zueoyesj	1037	5	Shannon	Shannon	NNP
cord-000248-zueoyesj	1037	6	Entropy	Entropy	NNP
cord-000248-zueoyesj	1037	7	of	of	IN
cord-000248-zueoyesj	1037	8	a	a	DT
cord-000248-zueoyesj	1037	9	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1037	10	sample	sample	NN
cord-000248-zueoyesj	1037	11	profile	profile	NN
cord-000248-zueoyesj	1037	12	,	,	,
cord-000248-zueoyesj	1037	13	then	then	RB
cord-000248-zueoyesj	1037	14	the	the	DT
cord-000248-zueoyesj	1037	15	MPR	MPR	NNP
cord-000248-zueoyesj	1037	16	-	-	HYPH
cord-000248-zueoyesj	1037	17	Statistical	Statistical	NNP
cord-000248-zueoyesj	1037	18	Complexity	Complexity	NNP
cord-000248-zueoyesj	1037	19	C	C	NNP
cord-000248-zueoyesj	1037	20	(	(	-LRB-
cord-000248-zueoyesj	1037	21	MPR	MPR	NNP
cord-000248-zueoyesj	1037	22	)	)	-RRB-
cord-000248-zueoyesj	1037	23	P	P	NNP
cord-000248-zueoyesj	1037	24	(	(	-LRB-
cord-000248-zueoyesj	1037	25	j	j	NNP
cord-000248-zueoyesj	1037	26	)	)	-RRB-
cord-000248-zueoyesj	1037	27	Â	â	NN
cord-000248-zueoyesj	1037	28	Ã	Ã	NNP
cord-000248-zueoyesj	1037	29	is	be	VBZ
cord-000248-zueoyesj	1037	30	defined	define	VBN
cord-000248-zueoyesj	1037	31	as	as	IN
cord-000248-zueoyesj	1037	32	being	be	VBG
cord-000248-zueoyesj	1037	33	proportional	proportional	JJ
cord-000248-zueoyesj	1037	34	to	to	IN
cord-000248-zueoyesj	1037	35	the	the	DT
cord-000248-zueoyesj	1037	36	product	product	NN
cord-000248-zueoyesj	1037	37	of	of	IN
cord-000248-zueoyesj	1037	38	the	the	DT
cord-000248-zueoyesj	1037	39	Normalized	Normalized	NNP
cord-000248-zueoyesj	1037	40	Shannon	Shannon	NNP
cord-000248-zueoyesj	1037	41	Entropy	Entropy	NNP
cord-000248-zueoyesj	1037	42	times	time	VBZ
cord-000248-zueoyesj	1037	43	the	the	DT
cord-000248-zueoyesj	1037	44	Jensen	Jensen	NNP
cord-000248-zueoyesj	1037	45	-	-	HYPH
cord-000248-zueoyesj	1037	46	Shannon	Shannon	NNP
cord-000248-zueoyesj	1037	47	divergence	divergence	NN
cord-000248-zueoyesj	1037	48	of	of	IN
cord-000248-zueoyesj	1037	49	the	the	DT
cord-000248-zueoyesj	1037	50	profile	profile	NN
cord-000248-zueoyesj	1037	51	with	with	IN
cord-000248-zueoyesj	1037	52	the	the	DT
cord-000248-zueoyesj	1037	53	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	1037	54	distribution	distribution	NN
cord-000248-zueoyesj	1037	55	(	(	-LRB-
cord-000248-zueoyesj	1037	56	in	in	IN
cord-000248-zueoyesj	1037	57	the	the	DT
cord-000248-zueoyesj	1037	58	example	example	NN
cord-000248-zueoyesj	1037	59	above	above	IN
cord-000248-zueoyesj	1037	60	the	the	DT
cord-000248-zueoyesj	1037	61	equiprobable	equiprobable	JJ
cord-000248-zueoyesj	1037	62	distribution	distribution	NN
cord-000248-zueoyesj	1037	63	is	be	VBZ
cord-000248-zueoyesj	1037	64	that	that	DT
cord-000248-zueoyesj	1037	65	of	of	IN
cord-000248-zueoyesj	1037	66	Sample	Sample	NNP
cord-000248-zueoyesj	1037	67	4	4	CD
cord-000248-zueoyesj	1037	68	)	)	-RRB-
cord-000248-zueoyesj	1037	69	.	.	.
cord-000248-zueoyesj	1038	1	Then	then	RB
cord-000248-zueoyesj	1038	2	we	-PRON-	PRP
cord-000248-zueoyesj	1038	3	have	have	VBP
cord-000248-zueoyesj	1038	4	Where	where	WRB
cord-000248-zueoyesj	1038	5	Q	Q	NNP
cord-000248-zueoyesj	1038	6	0	0	NFP
cord-000248-zueoyesj	1038	7	is	be	VBZ
cord-000248-zueoyesj	1038	8	a	a	DT
cord-000248-zueoyesj	1038	9	normalization	normalization	NN
cord-000248-zueoyesj	1038	10	factor	factor	NN
cord-000248-zueoyesj	1038	11	.	.	.
cord-000248-zueoyesj	1039	1	Once	once	RB
cord-000248-zueoyesj	1039	2	again	again	RB
cord-000248-zueoyesj	1039	3	,	,	,
cord-000248-zueoyesj	1039	4	we	-PRON-	PRP
cord-000248-zueoyesj	1039	5	refer	refer	VBP
cord-000248-zueoyesj	1039	6	to	to	IN
cord-000248-zueoyesj	1039	7	the	the	DT
cord-000248-zueoyesj	1039	8	'	'	``
cord-000248-zueoyesj	1039	9	Materials	material	NNS
cord-000248-zueoyesj	1039	10	and	and	CC
cord-000248-zueoyesj	1039	11	Methods	Methods	NNPS
cord-000248-zueoyesj	1039	12	'	'	POS
cord-000248-zueoyesj	1039	13	sections	section	NNS
cord-000248-zueoyesj	1039	14	for	for	IN
cord-000248-zueoyesj	1039	15	the	the	DT
cord-000248-zueoyesj	1039	16	accompanying	accompany	VBG
cord-000248-zueoyesj	1039	17	formal	formal	JJ
cord-000248-zueoyesj	1039	18	mathematical	mathematical	JJ
cord-000248-zueoyesj	1039	19	presentation	presentation	NN
cord-000248-zueoyesj	1039	20	.	.	.
cord-000248-zueoyesj	1040	1	As	as	IN
cord-000248-zueoyesj	1040	2	a	a	DT
cord-000248-zueoyesj	1040	3	consequence	consequence	NN
cord-000248-zueoyesj	1040	4	,	,	,
cord-000248-zueoyesj	1040	5	we	-PRON-	PRP
cord-000248-zueoyesj	1040	6	can	can	MD
cord-000248-zueoyesj	1040	7	plot	plot	VB
cord-000248-zueoyesj	1040	8	the	the	DT
cord-000248-zueoyesj	1040	9	MPR	MPR	NNP
cord-000248-zueoyesj	1040	10	-	-	HYPH
cord-000248-zueoyesj	1040	11	Statistical	Statistical	NNP
cord-000248-zueoyesj	1040	12	Complexity	Complexity	NNP
cord-000248-zueoyesj	1040	13	of	of	IN
cord-000248-zueoyesj	1040	14	the	the	DT
cord-000248-zueoyesj	1040	15	samples	sample	NNS
cord-000248-zueoyesj	1040	16	of	of	IN
cord-000248-zueoyesj	1040	17	our	-PRON-	PRP$
cord-000248-zueoyesj	1040	18	example	example	NN
cord-000248-zueoyesj	1040	19	as	as	IN
cord-000248-zueoyesj	1040	20	a	a	DT
cord-000248-zueoyesj	1040	21	function	function	NN
cord-000248-zueoyesj	1040	22	of	of	IN
cord-000248-zueoyesj	1040	23	the	the	DT
cord-000248-zueoyesj	1040	24	Normalized	Normalized	NNP
cord-000248-zueoyesj	1040	25	Shannon	Shannon	NNP
cord-000248-zueoyesj	1040	26	Entropy	Entropy	NNP
cord-000248-zueoyesj	1040	27	as	as	IN
cord-000248-zueoyesj	1040	28	can	can	MD
cord-000248-zueoyesj	1040	29	be	be	VB
cord-000248-zueoyesj	1040	30	seen	see	VBN
cord-000248-zueoyesj	1040	31	in	in	IN
cord-000248-zueoyesj	1040	32	Figure	Figure	NNP
cord-000248-zueoyesj	1040	33	22	22	CD
cord-000248-zueoyesj	1040	34	.	.	.
cord-000248-zueoyesj	1041	1	Annotated	annotated	JJ
cord-000248-zueoyesj	1041	2	genes	gene	NNS
cord-000248-zueoyesj	1041	3	.	.	.
cord-000248-zueoyesj	1042	1	A	a	DT
cord-000248-zueoyesj	1042	2	full	full	JJ
cord-000248-zueoyesj	1042	3	list	list	NN
cord-000248-zueoyesj	1042	4	of	of	IN
cord-000248-zueoyesj	1042	5	gene	gene	NN
cord-000248-zueoyesj	1042	6	references	reference	NNS
cord-000248-zueoyesj	1042	7	in	in	IN
cord-000248-zueoyesj	1042	8	this	this	DT
cord-000248-zueoyesj	1042	9	paper	paper	NN
cord-000248-zueoyesj	1042	10	along	along	IN
cord-000248-zueoyesj	1042	11	with	with	IN
cord-000248-zueoyesj	1042	12	their	-PRON-	PRP$
cord-000248-zueoyesj	1042	13	descriptions	description	NNS
cord-000248-zueoyesj	1042	14	from	from	IN
cord-000248-zueoyesj	1042	15	iHOP	ihop	JJ
cord-000248-zueoyesj	1042	16	(	(	-LRB-
cord-000248-zueoyesj	1042	17	http://www.ihop	http://www.ihop	NNP
cord-000248-zueoyesj	1042	18	-	-	HYPH
cord-000248-zueoyesj	1042	19	net	net	NN
cord-000248-zueoyesj	1042	20	.	.	.
cord-000248-zueoyesj	1043	1	org	org	NNP
cord-000248-zueoyesj	1043	2	/	/	SYM
cord-000248-zueoyesj	1043	3	UniPub	UniPub	NNP
cord-000248-zueoyesj	1043	4	/	/	SYM
cord-000248-zueoyesj	1043	5	iHOP/	iHOP/	NNP
cord-000248-zueoyesj	1043	6	)	)	-RRB-
cord-000248-zueoyesj	1043	7	can	can	MD
cord-000248-zueoyesj	1043	8	be	be	VB
cord-000248-zueoyesj	1043	9	found	find	VBN
cord-000248-zueoyesj	1043	10	in	in	IN
cord-000248-zueoyesj	1043	11	supplementary	supplementary	JJ
cord-000248-zueoyesj	1043	12	material	material	NN
cord-000248-zueoyesj	1043	13	reference	reference	NN
cord-000248-zueoyesj	1043	14	File	File	NNP
cord-000248-zueoyesj	1043	15	S5	S5	NNP
cord-000248-zueoyesj	1043	16	.	.	.
cord-000248-zueoyesj	1043	17	 	 	_SP
cord-000248-zueoyesj	1044	1	Stemness	Stemness	NNP
cord-000248-zueoyesj	1044	2	,	,	,
cord-000248-zueoyesj	1044	3	cancer	cancer	NN
cord-000248-zueoyesj	1044	4	and	and	CC
cord-000248-zueoyesj	1044	5	cancer	cancer	NN
cord-000248-zueoyesj	1044	6	stem	stem	NN
cord-000248-zueoyesj	1044	7	cells	cell	NNS
cord-000248-zueoyesj	1045	1	Stemness	Stemness	NNP
cord-000248-zueoyesj	1045	2	'	'	POS
cord-000248-zueoyesj	1045	3	'	'	''
cord-000248-zueoyesj	1045	4	genomics	genomic	NNS
cord-000248-zueoyesj	1045	5	law	law	NN
cord-000248-zueoyesj	1045	6	governs	govern	VBZ
cord-000248-zueoyesj	1045	7	clinical	clinical	JJ
cord-000248-zueoyesj	1045	8	behavior	behavior	NN
cord-000248-zueoyesj	1045	9	of	of	IN
cord-000248-zueoyesj	1045	10	human	human	JJ
cord-000248-zueoyesj	1045	11	cancer	cancer	NN
cord-000248-zueoyesj	1045	12	:	:	:
cord-000248-zueoyesj	1045	13	implications	implication	NNS
cord-000248-zueoyesj	1045	14	for	for	IN
cord-000248-zueoyesj	1045	15	decision	decision	NN
cord-000248-zueoyesj	1045	16	making	making	NN
cord-000248-zueoyesj	1045	17	in	in	IN
cord-000248-zueoyesj	1045	18	disease	disease	NN
cord-000248-zueoyesj	1045	19	management	management	NN
cord-000248-zueoyesj	1046	1	An	an	DT
cord-000248-zueoyesj	1046	2	embryonic	embryonic	JJ
cord-000248-zueoyesj	1046	3	stem	stem	NN
cord-000248-zueoyesj	1046	4	cell	cell	NN
cord-000248-zueoyesj	1046	5	-	-	HYPH
cord-000248-zueoyesj	1046	6	like	like	JJ
cord-000248-zueoyesj	1046	7	gene	gene	NN
cord-000248-zueoyesj	1046	8	expression	expression	NN
cord-000248-zueoyesj	1046	9	signature	signature	NN
cord-000248-zueoyesj	1046	10	in	in	IN
cord-000248-zueoyesj	1046	11	poorly	poorly	RB
cord-000248-zueoyesj	1046	12	differentiated	differentiate	VBN
cord-000248-zueoyesj	1046	13	aggressive	aggressive	JJ
cord-000248-zueoyesj	1046	14	human	human	JJ
cord-000248-zueoyesj	1046	15	tumors	tumor	NNS
cord-000248-zueoyesj	1046	16	Mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	1046	17	localization	localization	NN
cord-000248-zueoyesj	1046	18	,	,	,
cord-000248-zueoyesj	1046	19	ELK-1	elk-1	JJ
cord-000248-zueoyesj	1046	20	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1046	21	regulation	regulation	NN
cord-000248-zueoyesj	1046	22	and	and	CC
cord-000248-zueoyesj	1046	23	growth	growth	NN
cord-000248-zueoyesj	1046	24	inhibitory	inhibitory	JJ
cord-000248-zueoyesj	1046	25	functions	function	NNS
cord-000248-zueoyesj	1046	26	of	of	IN
cord-000248-zueoyesj	1046	27	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1046	28	,	,	,
cord-000248-zueoyesj	1046	29	BRCA1a	BRCA1a	NNP
cord-000248-zueoyesj	1046	30	,	,	,
cord-000248-zueoyesj	1046	31	and	and	CC
cord-000248-zueoyesj	1046	32	BRCA1b	BRCA1b	NNP
cord-000248-zueoyesj	1046	33	proteins	protein	NNS
cord-000248-zueoyesj	1046	34	Mitochondria	mitochondrion	NNS
cord-000248-zueoyesj	1046	35	and	and	CC
cord-000248-zueoyesj	1046	36	cancer	cancer	NN
cord-000248-zueoyesj	1046	37	Glucose	glucose	NN
cord-000248-zueoyesj	1046	38	avidity	avidity	NN
cord-000248-zueoyesj	1046	39	of	of	IN
cord-000248-zueoyesj	1046	40	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1046	41	Mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	1046	42	DNA	dna	NN
cord-000248-zueoyesj	1046	43	instability	instability	NN
cord-000248-zueoyesj	1046	44	and	and	CC
cord-000248-zueoyesj	1046	45	metabolic	metabolic	JJ
cord-000248-zueoyesj	1046	46	shift	shift	NN
cord-000248-zueoyesj	1046	47	in	in	IN
cord-000248-zueoyesj	1046	48	human	human	JJ
cord-000248-zueoyesj	1046	49	cancers	cancer	NNS
cord-000248-zueoyesj	1046	50	Roles	role	NNS
cord-000248-zueoyesj	1046	51	of	of	IN
cord-000248-zueoyesj	1046	52	p53	p53	NN
cord-000248-zueoyesj	1046	53	,	,	,
cord-000248-zueoyesj	1046	54	MYC	MYC	NNP
cord-000248-zueoyesj	1046	55	and	and	CC
cord-000248-zueoyesj	1046	56	HIF-1	HIF-1	NNP
cord-000248-zueoyesj	1047	1	in	in	IN
cord-000248-zueoyesj	1047	2	regulating	regulate	VBG
cord-000248-zueoyesj	1047	3	glycolysis	glycolysis	NN
cord-000248-zueoyesj	1047	4	-the	-the	NFP
cord-000248-zueoyesj	1047	5	seventh	seventh	JJ
cord-000248-zueoyesj	1047	6	hallmark	hallmark	NN
cord-000248-zueoyesj	1047	7	of	of	IN
cord-000248-zueoyesj	1047	8	cancer	cancer	NN
cord-000248-zueoyesj	1047	9	Alteration	Alteration	NNP
cord-000248-zueoyesj	1047	10	of	of	IN
cord-000248-zueoyesj	1047	11	the	the	DT
cord-000248-zueoyesj	1047	12	bioenergetic	bioenergetic	JJ
cord-000248-zueoyesj	1047	13	phenotype	phenotype	NN
cord-000248-zueoyesj	1047	14	of	of	IN
cord-000248-zueoyesj	1047	15	mitochondria	mitochondrion	NNS
cord-000248-zueoyesj	1047	16	is	be	VBZ
cord-000248-zueoyesj	1047	17	a	a	DT
cord-000248-zueoyesj	1047	18	hallmark	hallmark	NN
cord-000248-zueoyesj	1047	19	of	of	IN
cord-000248-zueoyesj	1047	20	breast	breast	NN
cord-000248-zueoyesj	1047	21	,	,	,
cord-000248-zueoyesj	1047	22	gastric	gastric	JJ
cord-000248-zueoyesj	1047	23	,	,	,
cord-000248-zueoyesj	1047	24	lung	lung	NN
cord-000248-zueoyesj	1047	25	and	and	CC
cord-000248-zueoyesj	1047	26	oesophageal	oesophageal	JJ
cord-000248-zueoyesj	1047	27	cancer	cancer	NN
cord-000248-zueoyesj	1047	28	Deregulation	deregulation	NN
cord-000248-zueoyesj	1047	29	of	of	IN
cord-000248-zueoyesj	1047	30	the	the	DT
cord-000248-zueoyesj	1047	31	G1	G1	NNP
cord-000248-zueoyesj	1047	32	/	/	SYM
cord-000248-zueoyesj	1047	33	S	s	NN
cord-000248-zueoyesj	1047	34	-	-	HYPH
cord-000248-zueoyesj	1047	35	phase	phase	NN
cord-000248-zueoyesj	1047	36	control	control	NN
cord-000248-zueoyesj	1047	37	in	in	IN
cord-000248-zueoyesj	1047	38	human	human	JJ
cord-000248-zueoyesj	1047	39	testicular	testicular	JJ
cord-000248-zueoyesj	1047	40	germ	germ	NN
cord-000248-zueoyesj	1047	41	cell	cell	NN
cord-000248-zueoyesj	1047	42	tumours	tumour	NNS
cord-000248-zueoyesj	1048	1	Aberrant	aberrant	JJ
cord-000248-zueoyesj	1048	2	DNA	dna	NN
cord-000248-zueoyesj	1048	3	methylation	methylation	NN
cord-000248-zueoyesj	1048	4	as	as	IN
cord-000248-zueoyesj	1048	5	a	a	DT
cord-000248-zueoyesj	1048	6	cancer	cancer	NN
cord-000248-zueoyesj	1048	7	-	-	HYPH
cord-000248-zueoyesj	1048	8	inducing	induce	VBG
cord-000248-zueoyesj	1048	9	mechanism	mechanism	NN
cord-000248-zueoyesj	1048	10	Promoter	Promoter	NNP
cord-000248-zueoyesj	1048	11	hypermethylation	hypermethylation	NN
cord-000248-zueoyesj	1048	12	of	of	IN
cord-000248-zueoyesj	1048	13	hallmark	hallmark	JJ
cord-000248-zueoyesj	1048	14	cancer	cancer	NN
cord-000248-zueoyesj	1048	15	genes	gene	NNS
cord-000248-zueoyesj	1048	16	in	in	IN
cord-000248-zueoyesj	1048	17	atypical	atypical	JJ
cord-000248-zueoyesj	1048	18	adenomatous	adenomatous	JJ
cord-000248-zueoyesj	1048	19	hyperplasia	hyperplasia	NN
cord-000248-zueoyesj	1048	20	of	of	IN
cord-000248-zueoyesj	1048	21	the	the	DT
cord-000248-zueoyesj	1048	22	lung	lung	NN
cord-000248-zueoyesj	1048	23	Loss	Loss	NNP
cord-000248-zueoyesj	1048	24	of	of	IN
cord-000248-zueoyesj	1048	25	acetylation	acetylation	NN
cord-000248-zueoyesj	1048	26	at	at	IN
cord-000248-zueoyesj	1048	27	Lys16	Lys16	NNP
cord-000248-zueoyesj	1048	28	and	and	CC
cord-000248-zueoyesj	1048	29	trimethylation	trimethylation	NN
cord-000248-zueoyesj	1048	30	at	at	IN
cord-000248-zueoyesj	1048	31	Lys20	Lys20	NNP
cord-000248-zueoyesj	1048	32	of	of	IN
cord-000248-zueoyesj	1048	33	histone	histone	NNP
cord-000248-zueoyesj	1048	34	H4	H4	NNP
cord-000248-zueoyesj	1048	35	is	be	VBZ
cord-000248-zueoyesj	1048	36	a	a	DT
cord-000248-zueoyesj	1048	37	common	common	JJ
cord-000248-zueoyesj	1048	38	hallmark	hallmark	NN
cord-000248-zueoyesj	1048	39	of	of	IN
cord-000248-zueoyesj	1048	40	human	human	JJ
cord-000248-zueoyesj	1048	41	cancer	cancer	NN
cord-000248-zueoyesj	1048	42	Metabolic	metabolic	JJ
cord-000248-zueoyesj	1048	43	transformation	transformation	NN
cord-000248-zueoyesj	1048	44	in	in	IN
cord-000248-zueoyesj	1048	45	cancer	cancer	NN
cord-000248-zueoyesj	1048	46	Metabolic	metabolic	JJ
cord-000248-zueoyesj	1048	47	targeting	targeting	NN
cord-000248-zueoyesj	1048	48	of	of	IN
cord-000248-zueoyesj	1048	49	cancers	cancer	NNS
cord-000248-zueoyesj	1048	50	:	:	:
cord-000248-zueoyesj	1048	51	from	from	IN
cord-000248-zueoyesj	1048	52	molecular	molecular	JJ
cord-000248-zueoyesj	1048	53	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1048	54	to	to	IN
cord-000248-zueoyesj	1048	55	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1048	56	strategies	strategy	NNS
cord-000248-zueoyesj	1048	57	Tumor	tumor	NN
cord-000248-zueoyesj	1048	58	cell	cell	NN
cord-000248-zueoyesj	1048	59	metabolism	metabolism	NN
cord-000248-zueoyesj	1048	60	:	:	:
cord-000248-zueoyesj	1048	61	cancer	cancer	NN
cord-000248-zueoyesj	1048	62	's	's	POS
cord-000248-zueoyesj	1048	63	Achilles	Achilles	NNP
cord-000248-zueoyesj	1048	64	'	'	POS
cord-000248-zueoyesj	1048	65	heel	heel	NN
cord-000248-zueoyesj	1048	66	Role	role	NN
cord-000248-zueoyesj	1048	67	of	of	IN
cord-000248-zueoyesj	1048	68	hypoxia	hypoxia	NN
cord-000248-zueoyesj	1048	69	in	in	IN
cord-000248-zueoyesj	1048	70	the	the	DT
cord-000248-zueoyesj	1048	71	hallmarks	hallmark	NNS
cord-000248-zueoyesj	1048	72	of	of	IN
cord-000248-zueoyesj	1048	73	human	human	JJ
cord-000248-zueoyesj	1048	74	cancer	cancer	NN
cord-000248-zueoyesj	1048	75	Adaptation	adaptation	NN
cord-000248-zueoyesj	1048	76	to	to	IN
cord-000248-zueoyesj	1048	77	hypoxia	hypoxia	NN
cord-000248-zueoyesj	1048	78	and	and	CC
cord-000248-zueoyesj	1048	79	acidosis	acidosis	NN
cord-000248-zueoyesj	1048	80	in	in	IN
cord-000248-zueoyesj	1048	81	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1048	82	and	and	CC
cord-000248-zueoyesj	1048	83	tumor	tumor	NN
cord-000248-zueoyesj	1048	84	progression	progression	NN
cord-000248-zueoyesj	1049	1	MicroRNAs	MicroRNAs	NNP
cord-000248-zueoyesj	1049	2	:	:	:
cord-000248-zueoyesj	1050	1	Novel	novel	JJ
cord-000248-zueoyesj	1050	2	regulators	regulator	NNS
cord-000248-zueoyesj	1050	3	in	in	IN
cord-000248-zueoyesj	1050	4	the	the	DT
cord-000248-zueoyesj	1050	5	hallmarks	hallmark	NNS
cord-000248-zueoyesj	1050	6	of	of	IN
cord-000248-zueoyesj	1050	7	human	human	JJ
cord-000248-zueoyesj	1050	8	cancer	cancer	NN
cord-000248-zueoyesj	1050	9	MicroRNAs	MicroRNAs	NNP
cord-000248-zueoyesj	1050	10	and	and	CC
cord-000248-zueoyesj	1050	11	the	the	DT
cord-000248-zueoyesj	1050	12	hallmarks	hallmark	NNS
cord-000248-zueoyesj	1050	13	of	of	IN
cord-000248-zueoyesj	1050	14	cancer	cancer	NN
cord-000248-zueoyesj	1050	15	Genetic	genetic	JJ
cord-000248-zueoyesj	1050	16	and	and	CC
cord-000248-zueoyesj	1050	17	epigenetic	epigenetic	JJ
cord-000248-zueoyesj	1050	18	mosaicism	mosaicism	NN
cord-000248-zueoyesj	1050	19	in	in	IN
cord-000248-zueoyesj	1050	20	cancer	cancer	NN
cord-000248-zueoyesj	1050	21	precursor	precursor	NN
cord-000248-zueoyesj	1050	22	tissues	tissue	VBZ
cord-000248-zueoyesj	1050	23	Road	Road	NNP
cord-000248-zueoyesj	1050	24	to	to	IN
cord-000248-zueoyesj	1050	25	the	the	DT
cord-000248-zueoyesj	1050	26	crossroads	crossroad	NNS
cord-000248-zueoyesj	1050	27	of	of	IN
cord-000248-zueoyesj	1050	28	life	life	NN
cord-000248-zueoyesj	1050	29	and	and	CC
cord-000248-zueoyesj	1050	30	death	death	NN
cord-000248-zueoyesj	1050	31	:	:	:
cord-000248-zueoyesj	1051	1	Linking	link	VBG
cord-000248-zueoyesj	1051	2	sister	sister	NN
cord-000248-zueoyesj	1051	3	chromatid	chromatid	JJ
cord-000248-zueoyesj	1051	4	cohesion	cohesion	NN
cord-000248-zueoyesj	1051	5	and	and	CC
cord-000248-zueoyesj	1051	6	separation	separation	NN
cord-000248-zueoyesj	1051	7	to	to	IN
cord-000248-zueoyesj	1051	8	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1051	9	,	,	,
cord-000248-zueoyesj	1051	10	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1051	11	and	and	CC
cord-000248-zueoyesj	1051	12	cancer	cancer	NN
cord-000248-zueoyesj	1051	13	Chromosome	chromosome	NN
cord-000248-zueoyesj	1051	14	aberrations	aberration	NNS
cord-000248-zueoyesj	1051	15	in	in	IN
cord-000248-zueoyesj	1051	16	solid	solid	JJ
cord-000248-zueoyesj	1051	17	tumors	tumor	NNS
cord-000248-zueoyesj	1051	18	Instability	instability	NN
cord-000248-zueoyesj	1051	19	of	of	IN
cord-000248-zueoyesj	1051	20	chromosome	chromosome	NN
cord-000248-zueoyesj	1051	21	structure	structure	NN
cord-000248-zueoyesj	1051	22	in	in	IN
cord-000248-zueoyesj	1051	23	cancer	cancer	NN
cord-000248-zueoyesj	1051	24	cells	cell	NNS
cord-000248-zueoyesj	1051	25	increases	increase	VBZ
cord-000248-zueoyesj	1051	26	exponentially	exponentially	RB
cord-000248-zueoyesj	1051	27	with	with	IN
cord-000248-zueoyesj	1051	28	degrees	degree	NNS
cord-000248-zueoyesj	1051	29	of	of	IN
cord-000248-zueoyesj	1051	30	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1052	1	Genetic	genetic	JJ
cord-000248-zueoyesj	1052	2	instability	instability	NN
cord-000248-zueoyesj	1052	3	of	of	IN
cord-000248-zueoyesj	1052	4	cancer	cancer	NN
cord-000248-zueoyesj	1052	5	cells	cell	NNS
cord-000248-zueoyesj	1052	6	is	be	VBZ
cord-000248-zueoyesj	1052	7	proportional	proportional	JJ
cord-000248-zueoyesj	1052	8	to	to	IN
cord-000248-zueoyesj	1052	9	their	-PRON-	PRP$
cord-000248-zueoyesj	1052	10	degree	degree	NN
cord-000248-zueoyesj	1052	11	of	of	IN
cord-000248-zueoyesj	1052	12	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1052	13	Cell	cell	NN
cord-000248-zueoyesj	1052	14	junctions	junction	NNS
cord-000248-zueoyesj	1052	15	and	and	CC
cord-000248-zueoyesj	1052	16	the	the	DT
cord-000248-zueoyesj	1052	17	biological	biological	JJ
cord-000248-zueoyesj	1052	18	behaviour	behaviour	NN
cord-000248-zueoyesj	1052	19	of	of	IN
cord-000248-zueoyesj	1052	20	cancer	cancer	NN
cord-000248-zueoyesj	1052	21	Mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	1052	22	gateways	gateway	NNS
cord-000248-zueoyesj	1052	23	to	to	IN
cord-000248-zueoyesj	1052	24	cancer	cancer	NN
cord-000248-zueoyesj	1052	25	Cancer	cancer	NN
cord-000248-zueoyesj	1052	26	-	-	HYPH
cord-000248-zueoyesj	1052	27	related	relate	VBN
cord-000248-zueoyesj	1052	28	inflammation	inflammation	NN
cord-000248-zueoyesj	1052	29	,	,	,
cord-000248-zueoyesj	1052	30	the	the	DT
cord-000248-zueoyesj	1052	31	seventh	seventh	JJ
cord-000248-zueoyesj	1052	32	hallmark	hallmark	NN
cord-000248-zueoyesj	1052	33	of	of	IN
cord-000248-zueoyesj	1052	34	cancer	cancer	NN
cord-000248-zueoyesj	1052	35	:	:	:
cord-000248-zueoyesj	1052	36	links	link	NNS
cord-000248-zueoyesj	1052	37	to	to	IN
cord-000248-zueoyesj	1052	38	genetic	genetic	JJ
cord-000248-zueoyesj	1052	39	instability	instability	NN
cord-000248-zueoyesj	1052	40	Pathways	pathway	NNS
cord-000248-zueoyesj	1052	41	connecting	connect	VBG
cord-000248-zueoyesj	1052	42	inflammation	inflammation	NN
cord-000248-zueoyesj	1052	43	and	and	CC
cord-000248-zueoyesj	1052	44	cancer	cancer	NN
cord-000248-zueoyesj	1052	45	Hallmarks	Hallmarks	NNP
cord-000248-zueoyesj	1052	46	for	for	IN
cord-000248-zueoyesj	1052	47	senescence	senescence	NN
cord-000248-zueoyesj	1052	48	in	in	IN
cord-000248-zueoyesj	1052	49	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1052	50	:	:	:
cord-000248-zueoyesj	1052	51	novel	novel	NN
cord-000248-zueoyesj	1052	52	signaling	signal	VBG
cord-000248-zueoyesj	1052	53	players	player	NNS
cord-000248-zueoyesj	1052	54	NF	NF	NNP
cord-000248-zueoyesj	1052	55	-	-	HYPH
cord-000248-zueoyesj	1052	56	kappaB	kappaB	NNP
cord-000248-zueoyesj	1052	57	and	and	CC
cord-000248-zueoyesj	1052	58	cancer	cancer	NN
cord-000248-zueoyesj	1052	59	-	-	HYPH
cord-000248-zueoyesj	1052	60	identifying	identify	VBG
cord-000248-zueoyesj	1052	61	targets	target	NNS
cord-000248-zueoyesj	1052	62	and	and	CC
cord-000248-zueoyesj	1052	63	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1052	64	Altered	alter	VBN
cord-000248-zueoyesj	1052	65	growth	growth	NN
cord-000248-zueoyesj	1052	66	pattern	pattern	NN
cord-000248-zueoyesj	1052	67	,	,	,
cord-000248-zueoyesj	1052	68	not	not	RB
cord-000248-zueoyesj	1052	69	altered	alter	VBN
cord-000248-zueoyesj	1052	70	growth	growth	NN
cord-000248-zueoyesj	1052	71	per	per	IN
cord-000248-zueoyesj	1052	72	se	se	FW
cord-000248-zueoyesj	1052	73	,	,	,
cord-000248-zueoyesj	1052	74	is	be	VBZ
cord-000248-zueoyesj	1052	75	the	the	DT
cord-000248-zueoyesj	1052	76	hallmark	hallmark	NN
cord-000248-zueoyesj	1052	77	of	of	IN
cord-000248-zueoyesj	1052	78	early	early	JJ
cord-000248-zueoyesj	1052	79	lesions	lesion	NNS
cord-000248-zueoyesj	1052	80	preceding	precede	VBG
cord-000248-zueoyesj	1052	81	cancer	cancer	NN
cord-000248-zueoyesj	1052	82	development	development	NN
cord-000248-zueoyesj	1052	83	MicroRNAs	MicroRNAs	NNP
cord-000248-zueoyesj	1052	84	and	and	CC
cord-000248-zueoyesj	1052	85	cancer	cancer	NN
cord-000248-zueoyesj	1052	86	epigenetics	epigenetic	NNS
cord-000248-zueoyesj	1053	1	Common	common	JJ
cord-000248-zueoyesj	1053	2	themes	theme	NNS
cord-000248-zueoyesj	1053	3	of	of	IN
cord-000248-zueoyesj	1053	4	dedifferentiation	dedifferentiation	NN
cord-000248-zueoyesj	1053	5	in	in	IN
cord-000248-zueoyesj	1053	6	somatic	somatic	JJ
cord-000248-zueoyesj	1053	7	cell	cell	NN
cord-000248-zueoyesj	1053	8	reprogramming	reprogramming	NN
cord-000248-zueoyesj	1053	9	and	and	CC
cord-000248-zueoyesj	1053	10	cancer	cancer	NN
cord-000248-zueoyesj	1053	11	Disruption	disruption	NN
cord-000248-zueoyesj	1053	12	of	of	IN
cord-000248-zueoyesj	1053	13	differentiation	differentiation	NN
cord-000248-zueoyesj	1053	14	in	in	IN
cord-000248-zueoyesj	1053	15	human	human	JJ
cord-000248-zueoyesj	1053	16	cancer	cancer	NN
cord-000248-zueoyesj	1053	17	:	:	:
cord-000248-zueoyesj	1053	18	AML	AML	NNP
cord-000248-zueoyesj	1053	19	shows	show	VBZ
cord-000248-zueoyesj	1053	20	the	the	DT
cord-000248-zueoyesj	1053	21	way	way	NN
cord-000248-zueoyesj	1053	22	Molecular	molecular	JJ
cord-000248-zueoyesj	1053	23	theory	theory	NN
cord-000248-zueoyesj	1053	24	of	of	IN
cord-000248-zueoyesj	1053	25	cancer	cancer	NN
cord-000248-zueoyesj	1053	26	Principles	principle	NNS
cord-000248-zueoyesj	1053	27	of	of	IN
cord-000248-zueoyesj	1053	28	cancer	cancer	NN
cord-000248-zueoyesj	1053	29	therapy	therapy	NN
cord-000248-zueoyesj	1053	30	:	:	:
cord-000248-zueoyesj	1053	31	oncogene	oncogene	NN
cord-000248-zueoyesj	1053	32	and	and	CC
cord-000248-zueoyesj	1053	33	non	non	JJ
cord-000248-zueoyesj	1053	34	-	-	JJ
cord-000248-zueoyesj	1053	35	oncogene	oncogene	JJ
cord-000248-zueoyesj	1053	36	addiction	addiction	NN
cord-000248-zueoyesj	1053	37	Stem	Stem	NNP
cord-000248-zueoyesj	1053	38	cell	cell	NN
cord-000248-zueoyesj	1053	39	regulation	regulation	NN
cord-000248-zueoyesj	1053	40	and	and	CC
cord-000248-zueoyesj	1053	41	the	the	DT
cord-000248-zueoyesj	1053	42	development	development	NN
cord-000248-zueoyesj	1053	43	of	of	IN
cord-000248-zueoyesj	1053	44	blast	blast	NN
cord-000248-zueoyesj	1053	45	crisis	crisis	NN
cord-000248-zueoyesj	1053	46	in	in	IN
cord-000248-zueoyesj	1053	47	chronic	chronic	JJ
cord-000248-zueoyesj	1053	48	myeloid	myeloid	NN
cord-000248-zueoyesj	1053	49	leukemia	leukemia	NN
cord-000248-zueoyesj	1053	50	:	:	:
cord-000248-zueoyesj	1053	51	Implications	implication	NNS
cord-000248-zueoyesj	1053	52	for	for	IN
cord-000248-zueoyesj	1053	53	the	the	DT
cord-000248-zueoyesj	1053	54	outcome	outcome	NN
cord-000248-zueoyesj	1053	55	of	of	IN
cord-000248-zueoyesj	1053	56	Imatinib	Imatinib	NNP
cord-000248-zueoyesj	1053	57	treatment	treatment	NN
cord-000248-zueoyesj	1053	58	and	and	CC
cord-000248-zueoyesj	1053	59	discontinuation	discontinuation	NN
cord-000248-zueoyesj	1053	60	Classification	classification	NN
cord-000248-zueoyesj	1053	61	of	of	IN
cord-000248-zueoyesj	1053	62	prostatic	prostatic	JJ
cord-000248-zueoyesj	1053	63	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1053	64	Trends	trend	NNS
cord-000248-zueoyesj	1053	65	in	in	IN
cord-000248-zueoyesj	1053	66	reporting	report	VBG
cord-000248-zueoyesj	1053	67	Gleason	Gleason	NNP
cord-000248-zueoyesj	1053	68	score	score	NN
cord-000248-zueoyesj	1053	69	1991	1991	CD
cord-000248-zueoyesj	1053	70	to	to	IN
cord-000248-zueoyesj	1053	71	2001	2001	CD
cord-000248-zueoyesj	1053	72	:	:	:
cord-000248-zueoyesj	1053	73	changes	change	NNS
cord-000248-zueoyesj	1053	74	in	in	IN
cord-000248-zueoyesj	1053	75	the	the	DT
cord-000248-zueoyesj	1053	76	pathologist	pathologist	NN
cord-000248-zueoyesj	1053	77	's	's	POS
cord-000248-zueoyesj	1053	78	practice	practice	NN
cord-000248-zueoyesj	1053	79	A	a	DT
cord-000248-zueoyesj	1053	80	comparison	comparison	NN
cord-000248-zueoyesj	1053	81	of	of	IN
cord-000248-zueoyesj	1053	82	interobserver	interobserver	NN
cord-000248-zueoyesj	1053	83	reproducibility	reproducibility	NN
cord-000248-zueoyesj	1053	84	of	of	IN
cord-000248-zueoyesj	1053	85	Gleason	Gleason	NNP
cord-000248-zueoyesj	1053	86	grading	grading	NN
cord-000248-zueoyesj	1053	87	of	of	IN
cord-000248-zueoyesj	1053	88	prostatic	prostatic	JJ
cord-000248-zueoyesj	1053	89	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1053	90	in	in	IN
cord-000248-zueoyesj	1053	91	Japan	Japan	NNP
cord-000248-zueoyesj	1053	92	and	and	CC
cord-000248-zueoyesj	1053	93	the	the	DT
cord-000248-zueoyesj	1053	94	United	United	NNP
cord-000248-zueoyesj	1053	95	States	States	NNP
cord-000248-zueoyesj	1053	96	Cutaneous	cutaneous	JJ
cord-000248-zueoyesj	1053	97	melanoma	melanoma	NN
cord-000248-zueoyesj	1053	98	:	:	:
cord-000248-zueoyesj	1053	99	available	available	JJ
cord-000248-zueoyesj	1053	100	therapy	therapy	NN
cord-000248-zueoyesj	1053	101	for	for	IN
cord-000248-zueoyesj	1053	102	metastatic	metastatic	JJ
cord-000248-zueoyesj	1053	103	disease	disease	NNP
cord-000248-zueoyesj	1053	104	Gene	Gene	NNP
cord-000248-zueoyesj	1053	105	expression	expression	NN
cord-000248-zueoyesj	1053	106	profiling	profiling	NN
cord-000248-zueoyesj	1053	107	identifies	identify	VBZ
cord-000248-zueoyesj	1053	108	clinically	clinically	RB
cord-000248-zueoyesj	1053	109	relevant	relevant	JJ
cord-000248-zueoyesj	1053	110	subtypes	subtype	NNS
cord-000248-zueoyesj	1053	111	of	of	IN
cord-000248-zueoyesj	1053	112	prostate	prostate	NN
cord-000248-zueoyesj	1053	113	cancer	cancer	NN
cord-000248-zueoyesj	1053	114	Revisiting	revisit	VBG
cord-000248-zueoyesj	1053	115	the	the	DT
cord-000248-zueoyesj	1053	116	relation	relation	NN
cord-000248-zueoyesj	1053	117	between	between	IN
cord-000248-zueoyesj	1053	118	species	species	NN
cord-000248-zueoyesj	1053	119	diversity	diversity	NN
cord-000248-zueoyesj	1053	120	and	and	CC
cord-000248-zueoyesj	1053	121	information	information	NN
cord-000248-zueoyesj	1053	122	theory	theory	NN
cord-000248-zueoyesj	1054	1	Differential	differential	JJ
cord-000248-zueoyesj	1054	2	post	post	JJ
cord-000248-zueoyesj	1054	3	-	-	JJ
cord-000248-zueoyesj	1054	4	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1054	5	regulation	regulation	NN
cord-000248-zueoyesj	1054	6	of	of	IN
cord-000248-zueoyesj	1054	7	two	two	CD
cord-000248-zueoyesj	1054	8	Ink4	Ink4	NNP
cord-000248-zueoyesj	1054	9	proteins	protein	NNS
cord-000248-zueoyesj	1054	10	,	,	,
cord-000248-zueoyesj	1055	1	p18(Ink4c	p18(ink4c	LS
cord-000248-zueoyesj	1055	2	)	)	-RRB-
cord-000248-zueoyesj	1056	1	and	and	CC
cord-000248-zueoyesj	1056	2	p19(Ink4d	p19(ink4d	CD
cord-000248-zueoyesj	1056	3	)	)	-RRB-
cord-000248-zueoyesj	1057	1	INK4	INK4	NNP
cord-000248-zueoyesj	1057	2	proteins	protein	NNS
cord-000248-zueoyesj	1057	3	,	,	,
cord-000248-zueoyesj	1057	4	a	a	DT
cord-000248-zueoyesj	1057	5	family	family	NN
cord-000248-zueoyesj	1057	6	of	of	IN
cord-000248-zueoyesj	1057	7	mammalian	mammalian	JJ
cord-000248-zueoyesj	1057	8	CDK	CDK	NNP
cord-000248-zueoyesj	1057	9	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	1057	10	with	with	IN
cord-000248-zueoyesj	1057	11	novel	novel	JJ
cord-000248-zueoyesj	1057	12	biological	biological	JJ
cord-000248-zueoyesj	1057	13	functions	function	NNS
cord-000248-zueoyesj	1057	14	Loss	Loss	NNP
cord-000248-zueoyesj	1057	15	of	of	IN
cord-000248-zueoyesj	1057	16	the	the	DT
cord-000248-zueoyesj	1057	17	forkhead	forkhead	NNP
cord-000248-zueoyesj	1057	18	transcription	transcription	NN
cord-000248-zueoyesj	1057	19	factor	factor	NN
cord-000248-zueoyesj	1058	1	FoxM1	FoxM1	NNP
cord-000248-zueoyesj	1058	2	causes	cause	VBZ
cord-000248-zueoyesj	1058	3	centrosome	centrosome	NN
cord-000248-zueoyesj	1058	4	amplification	amplification	NN
cord-000248-zueoyesj	1058	5	and	and	CC
cord-000248-zueoyesj	1058	6	mitotic	mitotic	JJ
cord-000248-zueoyesj	1058	7	catastrophe	catastrophe	NN
cord-000248-zueoyesj	1058	8	FoxM1	FoxM1	NNP
cord-000248-zueoyesj	1058	9	is	be	VBZ
cord-000248-zueoyesj	1058	10	required	require	VBN
cord-000248-zueoyesj	1058	11	for	for	IN
cord-000248-zueoyesj	1058	12	execution	execution	NN
cord-000248-zueoyesj	1058	13	of	of	IN
cord-000248-zueoyesj	1058	14	the	the	DT
cord-000248-zueoyesj	1058	15	mitotic	mitotic	JJ
cord-000248-zueoyesj	1058	16	programme	programme	NN
cord-000248-zueoyesj	1058	17	and	and	CC
cord-000248-zueoyesj	1058	18	chromosome	chromosome	NN
cord-000248-zueoyesj	1058	19	stability	stability	NN
cord-000248-zueoyesj	1059	1	The	the	DT
cord-000248-zueoyesj	1059	2	role	role	NN
cord-000248-zueoyesj	1059	3	of	of	IN
cord-000248-zueoyesj	1059	4	the	the	DT
cord-000248-zueoyesj	1059	5	BRCA2	brca2	NN
cord-000248-zueoyesj	1059	6	gene	gene	NN
cord-000248-zueoyesj	1059	7	in	in	IN
cord-000248-zueoyesj	1059	8	susceptibility	susceptibility	NN
cord-000248-zueoyesj	1059	9	to	to	IN
cord-000248-zueoyesj	1059	10	prostate	prostate	NN
cord-000248-zueoyesj	1059	11	cancer	cancer	NN
cord-000248-zueoyesj	1059	12	revisited	revisit	VBD
cord-000248-zueoyesj	1059	13	Prostate	Prostate	NNP
cord-000248-zueoyesj	1059	14	cancer	cancer	NN
cord-000248-zueoyesj	1059	15	in	in	IN
cord-000248-zueoyesj	1060	1	male	male	JJ
cord-000248-zueoyesj	1060	2	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1060	3	and	and	CC
cord-000248-zueoyesj	1060	4	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	1060	5	mutation	mutation	NN
cord-000248-zueoyesj	1060	6	carriers	carrier	NNS
cord-000248-zueoyesj	1060	7	has	have	VBZ
cord-000248-zueoyesj	1060	8	a	a	DT
cord-000248-zueoyesj	1060	9	more	more	RBR
cord-000248-zueoyesj	1060	10	aggressive	aggressive	JJ
cord-000248-zueoyesj	1060	11	phenotype	phenotype	NN
cord-000248-zueoyesj	1060	12	Down	down	IN
cord-000248-zueoyesj	1060	13	-	-	HYPH
cord-000248-zueoyesj	1060	14	regulation	regulation	NN
cord-000248-zueoyesj	1060	15	of	of	IN
cord-000248-zueoyesj	1060	16	BRCA2	brca2	JJ
cord-000248-zueoyesj	1060	17	expression	expression	NN
cord-000248-zueoyesj	1060	18	by	by	IN
cord-000248-zueoyesj	1060	19	collagen	collagen	NN
cord-000248-zueoyesj	1060	20	type	type	NN
cord-000248-zueoyesj	1060	21	I	-PRON-	PRP
cord-000248-zueoyesj	1060	22	promotes	promote	VBZ
cord-000248-zueoyesj	1060	23	prostate	prostate	NN
cord-000248-zueoyesj	1060	24	cancer	cancer	NN
cord-000248-zueoyesj	1060	25	cell	cell	NN
cord-000248-zueoyesj	1060	26	proliferation	proliferation	NN
cord-000248-zueoyesj	1060	27	BRCA2	brca2	IN
cord-000248-zueoyesj	1060	28	mutation	mutation	NN
cord-000248-zueoyesj	1060	29	in	in	IN
cord-000248-zueoyesj	1060	30	a	a	DT
cord-000248-zueoyesj	1060	31	family	family	NN
cord-000248-zueoyesj	1060	32	with	with	IN
cord-000248-zueoyesj	1060	33	hereditary	hereditary	JJ
cord-000248-zueoyesj	1060	34	prostate	prostate	NN
cord-000248-zueoyesj	1060	35	cancer	cancer	NN
cord-000248-zueoyesj	1060	36	Loss	loss	NN
cord-000248-zueoyesj	1060	37	of	of	IN
cord-000248-zueoyesj	1060	38	BRCA2	brca2	NN
cord-000248-zueoyesj	1060	39	promotes	promote	VBZ
cord-000248-zueoyesj	1060	40	prostate	prostate	NN
cord-000248-zueoyesj	1060	41	cancer	cancer	NN
cord-000248-zueoyesj	1060	42	cell	cell	NN
cord-000248-zueoyesj	1060	43	invasion	invasion	NN
cord-000248-zueoyesj	1060	44	through	through	IN
cord-000248-zueoyesj	1060	45	up	up	IN
cord-000248-zueoyesj	1060	46	-	-	HYPH
cord-000248-zueoyesj	1060	47	regulation	regulation	NN
cord-000248-zueoyesj	1060	48	of	of	IN
cord-000248-zueoyesj	1060	49	matrix	matrix	NN
cord-000248-zueoyesj	1060	50	metalloproteinase-9	metalloproteinase-9	NNP
cord-000248-zueoyesj	1060	51	Rapid	Rapid	NNP
cord-000248-zueoyesj	1060	52	progression	progression	NN
cord-000248-zueoyesj	1060	53	of	of	IN
cord-000248-zueoyesj	1060	54	prostate	prostate	NN
cord-000248-zueoyesj	1060	55	cancer	cancer	NN
cord-000248-zueoyesj	1060	56	in	in	IN
cord-000248-zueoyesj	1060	57	men	man	NNS
cord-000248-zueoyesj	1060	58	with	with	IN
cord-000248-zueoyesj	1060	59	a	a	DT
cord-000248-zueoyesj	1060	60	BRCA2	brca2	NN
cord-000248-zueoyesj	1060	61	mutation	mutation	NN
cord-000248-zueoyesj	1060	62	Rare	Rare	NNP
cord-000248-zueoyesj	1060	63	germline	germline	NN
cord-000248-zueoyesj	1060	64	mutations	mutation	NNS
cord-000248-zueoyesj	1060	65	in	in	IN
cord-000248-zueoyesj	1060	66	the	the	DT
cord-000248-zueoyesj	1060	67	BRCA2	brca2	NN
cord-000248-zueoyesj	1060	68	gene	gene	NN
cord-000248-zueoyesj	1060	69	are	be	VBP
cord-000248-zueoyesj	1060	70	associated	associate	VBN
cord-000248-zueoyesj	1060	71	with	with	IN
cord-000248-zueoyesj	1061	1	early	early	JJ
cord-000248-zueoyesj	1061	2	-	-	HYPH
cord-000248-zueoyesj	1061	3	onset	onset	NN
cord-000248-zueoyesj	1061	4	prostate	prostate	NN
cord-000248-zueoyesj	1061	5	cancer	cancer	NN
cord-000248-zueoyesj	1061	6	CCL2	CCL2	NNP
cord-000248-zueoyesj	1061	7	induces	induce	VBZ
cord-000248-zueoyesj	1061	8	prostate	prostate	NN
cord-000248-zueoyesj	1061	9	cancer	cancer	NN
cord-000248-zueoyesj	1061	10	transendothelial	transendothelial	JJ
cord-000248-zueoyesj	1061	11	cell	cell	NN
cord-000248-zueoyesj	1061	12	migration	migration	NN
cord-000248-zueoyesj	1061	13	via	via	IN
cord-000248-zueoyesj	1061	14	activation	activation	NN
cord-000248-zueoyesj	1061	15	of	of	IN
cord-000248-zueoyesj	1061	16	the	the	DT
cord-000248-zueoyesj	1061	17	small	small	JJ
cord-000248-zueoyesj	1061	18	GTPase	GTPase	NNP
cord-000248-zueoyesj	1061	19	Rac	Rac	NNP
cord-000248-zueoyesj	1061	20	Prostate	Prostate	NNP
cord-000248-zueoyesj	1061	21	cancer	cancer	NN
cord-000248-zueoyesj	1062	1	promotes	promote	VBZ
cord-000248-zueoyesj	1062	2	CD11b	CD11b	VBZ
cord-000248-zueoyesj	1062	3	positive	positive	JJ
cord-000248-zueoyesj	1062	4	cells	cell	NNS
cord-000248-zueoyesj	1062	5	to	to	TO
cord-000248-zueoyesj	1062	6	differentiate	differentiate	VB
cord-000248-zueoyesj	1062	7	into	into	IN
cord-000248-zueoyesj	1062	8	osteoclasts	osteoclast	NNS
cord-000248-zueoyesj	1063	1	A	a	DT
cord-000248-zueoyesj	1063	2	destructive	destructive	JJ
cord-000248-zueoyesj	1063	3	cascade	cascade	NN
cord-000248-zueoyesj	1063	4	mediated	mediate	VBN
cord-000248-zueoyesj	1063	5	by	by	IN
cord-000248-zueoyesj	1063	6	CCL2	CCL2	NNP
cord-000248-zueoyesj	1063	7	facilitates	facilitate	VBZ
cord-000248-zueoyesj	1063	8	prostate	prostate	NN
cord-000248-zueoyesj	1063	9	cancer	cancer	NN
cord-000248-zueoyesj	1063	10	growth	growth	NN
cord-000248-zueoyesj	1063	11	in	in	IN
cord-000248-zueoyesj	1063	12	bone	bone	NN
cord-000248-zueoyesj	1063	13	CCL2	CCL2	NNP
cord-000248-zueoyesj	1063	14	is	be	VBZ
cord-000248-zueoyesj	1063	15	a	a	DT
cord-000248-zueoyesj	1063	16	potent	potent	JJ
cord-000248-zueoyesj	1063	17	regulator	regulator	NN
cord-000248-zueoyesj	1063	18	of	of	IN
cord-000248-zueoyesj	1063	19	prostate	prostate	NN
cord-000248-zueoyesj	1063	20	cancer	cancer	NN
cord-000248-zueoyesj	1063	21	cell	cell	NN
cord-000248-zueoyesj	1063	22	migration	migration	NN
cord-000248-zueoyesj	1063	23	and	and	CC
cord-000248-zueoyesj	1063	24	proliferation	proliferation	NN
cord-000248-zueoyesj	1063	25	CCL2	CCL2	NNP
cord-000248-zueoyesj	1063	26	,	,	,
cord-000248-zueoyesj	1063	27	survivin	survivin	NN
cord-000248-zueoyesj	1063	28	and	and	CC
cord-000248-zueoyesj	1063	29	autophagy	autophagy	NN
cord-000248-zueoyesj	1063	30	:	:	:
cord-000248-zueoyesj	1063	31	new	new	JJ
cord-000248-zueoyesj	1063	32	links	link	NNS
cord-000248-zueoyesj	1063	33	with	with	IN
cord-000248-zueoyesj	1063	34	implications	implication	NNS
cord-000248-zueoyesj	1063	35	in	in	IN
cord-000248-zueoyesj	1063	36	human	human	JJ
cord-000248-zueoyesj	1063	37	cancer	cancer	NN
cord-000248-zueoyesj	1063	38	CCL2	CCL2	NNP
cord-000248-zueoyesj	1063	39	protects	protect	VBZ
cord-000248-zueoyesj	1063	40	prostate	prostate	NN
cord-000248-zueoyesj	1063	41	cancer	cancer	NN
cord-000248-zueoyesj	1063	42	PC3	PC3	NNP
cord-000248-zueoyesj	1063	43	cells	cell	NNS
cord-000248-zueoyesj	1063	44	from	from	IN
cord-000248-zueoyesj	1063	45	autophagic	autophagic	JJ
cord-000248-zueoyesj	1063	46	death	death	NN
cord-000248-zueoyesj	1063	47	via	via	IN
cord-000248-zueoyesj	1063	48	phosphatidylinositol	phosphatidylinositol	JJ
cord-000248-zueoyesj	1063	49	3-kinase	3-kinase	CD
cord-000248-zueoyesj	1063	50	/	/	SYM
cord-000248-zueoyesj	1063	51	AKT	akt	NN
cord-000248-zueoyesj	1063	52	-	-	HYPH
cord-000248-zueoyesj	1063	53	dependent	dependent	JJ
cord-000248-zueoyesj	1063	54	survivin	survivin	NN
cord-000248-zueoyesj	1063	55	up	up	IN
cord-000248-zueoyesj	1063	56	-	-	HYPH
cord-000248-zueoyesj	1063	57	regulation	regulation	NN
cord-000248-zueoyesj	1063	58	Co	co	NN
cord-000248-zueoyesj	1063	59	-	-	NN
cord-000248-zueoyesj	1063	60	inoculation	inoculation	NN
cord-000248-zueoyesj	1063	61	of	of	IN
cord-000248-zueoyesj	1063	62	prostate	prostate	NN
cord-000248-zueoyesj	1063	63	cancer	cancer	NN
cord-000248-zueoyesj	1063	64	cells	cell	NNS
cord-000248-zueoyesj	1063	65	with	with	IN
cord-000248-zueoyesj	1063	66	U937	U937	NNP
cord-000248-zueoyesj	1063	67	enhances	enhance	VBZ
cord-000248-zueoyesj	1063	68	tumor	tumor	NN
cord-000248-zueoyesj	1063	69	growth	growth	NN
cord-000248-zueoyesj	1063	70	and	and	CC
cord-000248-zueoyesj	1063	71	angiogenesis	angiogenesis	NN
cord-000248-zueoyesj	1063	72	in	in	IN
cord-000248-zueoyesj	1063	73	vivo	vivo	NN
cord-000248-zueoyesj	1064	1	PTHrPinduced	PTHrPinduced	NNP
cord-000248-zueoyesj	1064	2	MCP-1	MCP-1	NNP
cord-000248-zueoyesj	1064	3	production	production	NN
cord-000248-zueoyesj	1064	4	by	by	IN
cord-000248-zueoyesj	1064	5	human	human	JJ
cord-000248-zueoyesj	1064	6	bone	bone	NN
cord-000248-zueoyesj	1064	7	marrow	marrow	NN
cord-000248-zueoyesj	1064	8	endothelial	endothelial	JJ
cord-000248-zueoyesj	1064	9	cells	cell	NNS
cord-000248-zueoyesj	1064	10	and	and	CC
cord-000248-zueoyesj	1064	11	osteoblasts	osteoblast	NNS
cord-000248-zueoyesj	1064	12	promotes	promote	VBZ
cord-000248-zueoyesj	1064	13	osteoclast	osteoclast	JJ
cord-000248-zueoyesj	1064	14	differentiation	differentiation	NN
cord-000248-zueoyesj	1064	15	and	and	CC
cord-000248-zueoyesj	1064	16	prostate	prostate	NN
cord-000248-zueoyesj	1064	17	cancer	cancer	NN
cord-000248-zueoyesj	1064	18	cell	cell	NN
cord-000248-zueoyesj	1064	19	proliferation	proliferation	NN
cord-000248-zueoyesj	1064	20	and	and	CC
cord-000248-zueoyesj	1064	21	invasion	invasion	NN
cord-000248-zueoyesj	1064	22	in	in	IN
cord-000248-zueoyesj	1064	23	vitro	vitro	FW
cord-000248-zueoyesj	1065	1	Monocyte	Monocyte	NNP
cord-000248-zueoyesj	1065	2	chemotactic	chemotactic	VBD
cord-000248-zueoyesj	1065	3	protein-1	protein-1	NNP
cord-000248-zueoyesj	1065	4	mediates	mediate	VBZ
cord-000248-zueoyesj	1065	5	prostate	prostate	NN
cord-000248-zueoyesj	1065	6	cancer	cancer	NN
cord-000248-zueoyesj	1065	7	-	-	HYPH
cord-000248-zueoyesj	1065	8	induced	induce	VBN
cord-000248-zueoyesj	1065	9	bone	bone	NN
cord-000248-zueoyesj	1065	10	resorption	resorption	NN
cord-000248-zueoyesj	1065	11	CCL2	CCL2	NNP
cord-000248-zueoyesj	1065	12	as	as	IN
cord-000248-zueoyesj	1065	13	an	an	DT
cord-000248-zueoyesj	1065	14	important	important	JJ
cord-000248-zueoyesj	1065	15	mediator	mediator	NN
cord-000248-zueoyesj	1065	16	of	of	IN
cord-000248-zueoyesj	1065	17	prostate	prostate	NN
cord-000248-zueoyesj	1065	18	cancer	cancer	NN
cord-000248-zueoyesj	1065	19	growth	growth	NN
cord-000248-zueoyesj	1065	20	in	in	IN
cord-000248-zueoyesj	1065	21	vivo	vivo	NN
cord-000248-zueoyesj	1065	22	through	through	IN
cord-000248-zueoyesj	1065	23	the	the	DT
cord-000248-zueoyesj	1065	24	regulation	regulation	NN
cord-000248-zueoyesj	1065	25	of	of	IN
cord-000248-zueoyesj	1065	26	macrophage	macrophage	NN
cord-000248-zueoyesj	1065	27	infiltration	infiltration	NN
cord-000248-zueoyesj	1065	28	Targeting	target	VBG
cord-000248-zueoyesj	1065	29	CCL2	CCL2	NNP
cord-000248-zueoyesj	1065	30	with	with	IN
cord-000248-zueoyesj	1065	31	systemic	systemic	JJ
cord-000248-zueoyesj	1065	32	delivery	delivery	NN
cord-000248-zueoyesj	1065	33	of	of	IN
cord-000248-zueoyesj	1065	34	neutralizing	neutralize	VBG
cord-000248-zueoyesj	1065	35	antibodies	antibody	NNS
cord-000248-zueoyesj	1065	36	induces	induce	VBZ
cord-000248-zueoyesj	1065	37	prostate	prostate	NN
cord-000248-zueoyesj	1065	38	cancer	cancer	NN
cord-000248-zueoyesj	1065	39	tumor	tumor	NN
cord-000248-zueoyesj	1065	40	regression	regression	NN
cord-000248-zueoyesj	1065	41	in	in	IN
cord-000248-zueoyesj	1065	42	vivo	vivo	NNP
cord-000248-zueoyesj	1065	43	PAR1-mediated	PAR1-mediated	NNP
cord-000248-zueoyesj	1065	44	RhoA	RhoA	NNP
cord-000248-zueoyesj	1065	45	activation	activation	NN
cord-000248-zueoyesj	1065	46	facilitates	facilitate	VBZ
cord-000248-zueoyesj	1065	47	CCL2-induced	ccl2-induced	JJ
cord-000248-zueoyesj	1065	48	chemotaxis	chemotaxis	NN
cord-000248-zueoyesj	1065	49	in	in	IN
cord-000248-zueoyesj	1065	50	PC-3	PC-3	NNP
cord-000248-zueoyesj	1065	51	cells	cell	NNS
cord-000248-zueoyesj	1065	52	Identification	identification	NN
cord-000248-zueoyesj	1065	53	of	of	IN
cord-000248-zueoyesj	1065	54	differentially	differentially	RB
cord-000248-zueoyesj	1065	55	expressed	express	VBN
cord-000248-zueoyesj	1065	56	genes	gene	NNS
cord-000248-zueoyesj	1065	57	in	in	IN
cord-000248-zueoyesj	1065	58	organ	organ	NN
cord-000248-zueoyesj	1065	59	-	-	HYPH
cord-000248-zueoyesj	1065	60	confined	confine	VBN
cord-000248-zueoyesj	1065	61	prostate	prostate	NN
cord-000248-zueoyesj	1065	62	cancer	cancer	NN
cord-000248-zueoyesj	1065	63	by	by	IN
cord-000248-zueoyesj	1065	64	gene	gene	NN
cord-000248-zueoyesj	1065	65	expression	expression	NN
cord-000248-zueoyesj	1065	66	array	array	NN
cord-000248-zueoyesj	1066	1	The	the	DT
cord-000248-zueoyesj	1066	2	role	role	NN
cord-000248-zueoyesj	1066	3	of	of	IN
cord-000248-zueoyesj	1066	4	c	c	NN
cord-000248-zueoyesj	1066	5	-	-	:
cord-000248-zueoyesj	1066	6	Jun	Jun	NNP
cord-000248-zueoyesj	1066	7	and	and	CC
cord-000248-zueoyesj	1066	8	c	c	NNP
cord-000248-zueoyesj	1066	9	-	-	:
cord-000248-zueoyesj	1066	10	Fos	Fos	NNP
cord-000248-zueoyesj	1066	11	expression	expression	NN
cord-000248-zueoyesj	1066	12	in	in	IN
cord-000248-zueoyesj	1066	13	androgen	androgen	NN
cord-000248-zueoyesj	1066	14	-	-	HYPH
cord-000248-zueoyesj	1066	15	independent	independent	JJ
cord-000248-zueoyesj	1066	16	prostate	prostate	NN
cord-000248-zueoyesj	1066	17	cancer	cancer	NN
cord-000248-zueoyesj	1066	18	Molecular	Molecular	NNP
cord-000248-zueoyesj	1066	19	Cancer	Cancer	NNP
cord-000248-zueoyesj	1066	20	Phenotype	Phenotype	NNP
cord-000248-zueoyesj	1066	21	in	in	IN
cord-000248-zueoyesj	1066	22	Normal	normal	JJ
cord-000248-zueoyesj	1066	23	Prostate	Prostate	NNP
cord-000248-zueoyesj	1066	24	Tissue	Tissue	NNP
cord-000248-zueoyesj	1066	25	Activator	Activator	NNP
cord-000248-zueoyesj	1066	26	protein-1	protein-1	NNP
cord-000248-zueoyesj	1066	27	transcription	transcription	NN
cord-000248-zueoyesj	1066	28	factors	factor	NNS
cord-000248-zueoyesj	1066	29	are	be	VBP
cord-000248-zueoyesj	1066	30	associated	associate	VBN
cord-000248-zueoyesj	1066	31	with	with	IN
cord-000248-zueoyesj	1066	32	progression	progression	NN
cord-000248-zueoyesj	1066	33	and	and	CC
cord-000248-zueoyesj	1066	34	recurrence	recurrence	NN
cord-000248-zueoyesj	1066	35	of	of	IN
cord-000248-zueoyesj	1066	36	prostate	prostate	NN
cord-000248-zueoyesj	1066	37	cancer	cancer	NN
cord-000248-zueoyesj	1066	38	Raf-1	Raf-1	NNP
cord-000248-zueoyesj	1066	39	expression	expression	NN
cord-000248-zueoyesj	1066	40	may	may	MD
cord-000248-zueoyesj	1066	41	influence	influence	VB
cord-000248-zueoyesj	1066	42	progression	progression	NN
cord-000248-zueoyesj	1066	43	to	to	IN
cord-000248-zueoyesj	1066	44	androgen	androgen	NN
cord-000248-zueoyesj	1067	1	insensitive	insensitive	JJ
cord-000248-zueoyesj	1067	2	prostate	prostate	NN
cord-000248-zueoyesj	1067	3	cancer	cancer	NN
cord-000248-zueoyesj	1067	4	A	a	DT
cord-000248-zueoyesj	1067	5	mechanism	mechanism	NN
cord-000248-zueoyesj	1067	6	of	of	IN
cord-000248-zueoyesj	1067	7	AP-1	AP-1	NNP
cord-000248-zueoyesj	1067	8	suppression	suppression	NN
cord-000248-zueoyesj	1067	9	through	through	IN
cord-000248-zueoyesj	1067	10	interaction	interaction	NN
cord-000248-zueoyesj	1067	11	of	of	IN
cord-000248-zueoyesj	1067	12	c	c	NN
cord-000248-zueoyesj	1067	13	-	-	:
cord-000248-zueoyesj	1067	14	Fos	Fos	NNP
cord-000248-zueoyesj	1067	15	with	with	IN
cord-000248-zueoyesj	1067	16	lamin	lamin	NN
cord-000248-zueoyesj	1067	17	A	A	NNP
cord-000248-zueoyesj	1067	18	/	/	SYM
cord-000248-zueoyesj	1067	19	C	C	NNP
cord-000248-zueoyesj	1067	20	Fast	fast	JJ
cord-000248-zueoyesj	1067	21	regulation	regulation	NN
cord-000248-zueoyesj	1067	22	of	of	IN
cord-000248-zueoyesj	1067	23	AP-1	AP-1	NNP
cord-000248-zueoyesj	1067	24	activity	activity	NN
cord-000248-zueoyesj	1067	25	through	through	IN
cord-000248-zueoyesj	1067	26	interaction	interaction	NN
cord-000248-zueoyesj	1067	27	of	of	IN
cord-000248-zueoyesj	1067	28	lamin	lamin	NNP
cord-000248-zueoyesj	1067	29	A	A	NNP
cord-000248-zueoyesj	1067	30	/	/	SYM
cord-000248-zueoyesj	1067	31	C	C	NNP
cord-000248-zueoyesj	1067	32	,	,	,
cord-000248-zueoyesj	1067	33	ERK1/2	ERK1/2	NNP
cord-000248-zueoyesj	1067	34	,	,	,
cord-000248-zueoyesj	1067	35	and	and	CC
cord-000248-zueoyesj	1067	36	c	c	LS
cord-000248-zueoyesj	1067	37	-	-	:
cord-000248-zueoyesj	1067	38	Fos	Fos	NNP
cord-000248-zueoyesj	1067	39	at	at	IN
cord-000248-zueoyesj	1067	40	the	the	DT
cord-000248-zueoyesj	1067	41	nuclear	nuclear	JJ
cord-000248-zueoyesj	1067	42	envelope	envelope	NN
cord-000248-zueoyesj	1068	1	The	the	DT
cord-000248-zueoyesj	1068	2	role	role	NN
cord-000248-zueoyesj	1068	3	of	of	IN
cord-000248-zueoyesj	1068	4	Sox9	Sox9	NNP
cord-000248-zueoyesj	1068	5	in	in	IN
cord-000248-zueoyesj	1068	6	prostate	prostate	NN
cord-000248-zueoyesj	1068	7	development	development	NN
cord-000248-zueoyesj	1069	1	Sox9	Sox9	NNP
cord-000248-zueoyesj	1069	2	is	be	VBZ
cord-000248-zueoyesj	1069	3	required	require	VBN
cord-000248-zueoyesj	1069	4	for	for	IN
cord-000248-zueoyesj	1069	5	prostate	prostate	NN
cord-000248-zueoyesj	1069	6	development	development	NN
cord-000248-zueoyesj	1069	7	Sexual	sexual	JJ
cord-000248-zueoyesj	1069	8	differentiation	differentiation	NN
cord-000248-zueoyesj	1070	1	Androgen	androgen	NN
cord-000248-zueoyesj	1070	2	-	-	HYPH
cord-000248-zueoyesj	1070	3	induced	induce	VBN
cord-000248-zueoyesj	1070	4	programs	program	NNS
cord-000248-zueoyesj	1070	5	for	for	IN
cord-000248-zueoyesj	1070	6	prostate	prostate	NN
cord-000248-zueoyesj	1070	7	epithelial	epithelial	JJ
cord-000248-zueoyesj	1070	8	growth	growth	NN
cord-000248-zueoyesj	1070	9	and	and	CC
cord-000248-zueoyesj	1070	10	invasion	invasion	NN
cord-000248-zueoyesj	1070	11	arise	arise	VBP
cord-000248-zueoyesj	1070	12	in	in	IN
cord-000248-zueoyesj	1070	13	embryogenesis	embryogenesis	NN
cord-000248-zueoyesj	1070	14	and	and	CC
cord-000248-zueoyesj	1070	15	are	be	VBP
cord-000248-zueoyesj	1070	16	reactivated	reactivate	VBN
cord-000248-zueoyesj	1070	17	in	in	IN
cord-000248-zueoyesj	1070	18	cancer	cancer	NN
cord-000248-zueoyesj	1070	19	SOX9	SOX9	NNP
cord-000248-zueoyesj	1070	20	is	be	VBZ
cord-000248-zueoyesj	1070	21	expressed	express	VBN
cord-000248-zueoyesj	1070	22	in	in	IN
cord-000248-zueoyesj	1070	23	normal	normal	JJ
cord-000248-zueoyesj	1070	24	prostate	prostate	NN
cord-000248-zueoyesj	1070	25	basal	basal	NN
cord-000248-zueoyesj	1070	26	cells	cell	NNS
cord-000248-zueoyesj	1070	27	and	and	CC
cord-000248-zueoyesj	1070	28	regulates	regulate	VBZ
cord-000248-zueoyesj	1070	29	androgen	androgen	NN
cord-000248-zueoyesj	1070	30	receptor	receptor	NN
cord-000248-zueoyesj	1070	31	expression	expression	NN
cord-000248-zueoyesj	1070	32	in	in	IN
cord-000248-zueoyesj	1070	33	prostate	prostate	NN
cord-000248-zueoyesj	1070	34	cancer	cancer	NN
cord-000248-zueoyesj	1070	35	cells	cell	NNS
cord-000248-zueoyesj	1071	1	Inducible	inducible	JJ
cord-000248-zueoyesj	1071	2	FGFR-1	fgfr-1	NN
cord-000248-zueoyesj	1071	3	activation	activation	NN
cord-000248-zueoyesj	1071	4	leads	lead	VBZ
cord-000248-zueoyesj	1071	5	to	to	IN
cord-000248-zueoyesj	1071	6	irreversible	irreversible	JJ
cord-000248-zueoyesj	1071	7	prostate	prostate	NN
cord-000248-zueoyesj	1071	8	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1071	9	and	and	CC
cord-000248-zueoyesj	1071	10	an	an	DT
cord-000248-zueoyesj	1071	11	epithelial	epithelial	NN
cord-000248-zueoyesj	1071	12	-	-	HYPH
cord-000248-zueoyesj	1071	13	to	to	IN
cord-000248-zueoyesj	1071	14	-	-	HYPH
cord-000248-zueoyesj	1071	15	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	1071	16	transition	transition	NN
cord-000248-zueoyesj	1071	17	SOX9	SOX9	NNP
cord-000248-zueoyesj	1071	18	is	be	VBZ
cord-000248-zueoyesj	1071	19	expressed	express	VBN
cord-000248-zueoyesj	1071	20	in	in	IN
cord-000248-zueoyesj	1071	21	human	human	JJ
cord-000248-zueoyesj	1071	22	fetal	fetal	JJ
cord-000248-zueoyesj	1071	23	prostate	prostate	NN
cord-000248-zueoyesj	1071	24	epithelium	epithelium	NN
cord-000248-zueoyesj	1071	25	and	and	CC
cord-000248-zueoyesj	1071	26	enhances	enhance	VBZ
cord-000248-zueoyesj	1071	27	prostate	prostate	NN
cord-000248-zueoyesj	1071	28	cancer	cancer	NN
cord-000248-zueoyesj	1071	29	invasion	invasion	NN
cord-000248-zueoyesj	1071	30	Calcification	calcification	NN
cord-000248-zueoyesj	1071	31	of	of	IN
cord-000248-zueoyesj	1071	32	multipotent	multipotent	JJ
cord-000248-zueoyesj	1071	33	prostate	prostate	NN
cord-000248-zueoyesj	1071	34	tumor	tumor	NN
cord-000248-zueoyesj	1071	35	endothelium	endothelium	NN
cord-000248-zueoyesj	1072	1	Multivariate	multivariate	JJ
cord-000248-zueoyesj	1072	2	gene	gene	NN
cord-000248-zueoyesj	1072	3	expression	expression	NN
cord-000248-zueoyesj	1072	4	analysis	analysis	NN
cord-000248-zueoyesj	1072	5	reveals	reveal	VBZ
cord-000248-zueoyesj	1072	6	functional	functional	JJ
cord-000248-zueoyesj	1072	7	connectivity	connectivity	NN
cord-000248-zueoyesj	1072	8	changes	change	NNS
cord-000248-zueoyesj	1072	9	between	between	IN
cord-000248-zueoyesj	1072	10	normal	normal	JJ
cord-000248-zueoyesj	1072	11	/	/	SYM
cord-000248-zueoyesj	1072	12	tumoral	tumoral	JJ
cord-000248-zueoyesj	1072	13	prostates	prostates	NNPS
cord-000248-zueoyesj	1072	14	PSA	PSA	NNP
cord-000248-zueoyesj	1072	15	response	response	NN
cord-000248-zueoyesj	1072	16	signatures	signature	NNS
cord-000248-zueoyesj	1072	17	-a	-a	:
cord-000248-zueoyesj	1072	18	powerful	powerful	JJ
cord-000248-zueoyesj	1072	19	new	new	JJ
cord-000248-zueoyesj	1072	20	prognostic	prognostic	JJ
cord-000248-zueoyesj	1072	21	indicator	indicator	NN
cord-000248-zueoyesj	1072	22	after	after	IN
cord-000248-zueoyesj	1072	23	radiation	radiation	NN
cord-000248-zueoyesj	1072	24	for	for	IN
cord-000248-zueoyesj	1072	25	prostate	prostate	NN
cord-000248-zueoyesj	1072	26	cancer	cancer	NN
cord-000248-zueoyesj	1072	27	?	?	.
cord-000248-zueoyesj	1073	1	First	first	JJ
cord-000248-zueoyesj	1073	2	results	result	NNS
cord-000248-zueoyesj	1073	3	of	of	IN
cord-000248-zueoyesj	1073	4	PET/	PET/	NNP
cord-000248-zueoyesj	1073	5	CT	CT	NNP
cord-000248-zueoyesj	1073	6	-	-	HYPH
cord-000248-zueoyesj	1073	7	guided	guide	VBN
cord-000248-zueoyesj	1073	8	secondary	secondary	JJ
cord-000248-zueoyesj	1073	9	lymph	lymph	NN
cord-000248-zueoyesj	1073	10	node	node	NN
cord-000248-zueoyesj	1073	11	surgery	surgery	NN
cord-000248-zueoyesj	1073	12	on	on	IN
cord-000248-zueoyesj	1073	13	patients	patient	NNS
cord-000248-zueoyesj	1073	14	with	with	IN
cord-000248-zueoyesj	1073	15	a	a	DT
cord-000248-zueoyesj	1073	16	PSA	PSA	NNP
cord-000248-zueoyesj	1073	17	relapse	relapse	NN
cord-000248-zueoyesj	1073	18	after	after	IN
cord-000248-zueoyesj	1073	19	radical	radical	JJ
cord-000248-zueoyesj	1073	20	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1073	21	Vascular	vascular	JJ
cord-000248-zueoyesj	1073	22	endothelial	endothelial	JJ
cord-000248-zueoyesj	1073	23	growth	growth	NN
cord-000248-zueoyesj	1073	24	factor	factor	NN
cord-000248-zueoyesj	1073	25	receptor	receptor	NN
cord-000248-zueoyesj	1073	26	1	1	CD
cord-000248-zueoyesj	1073	27	expression	expression	NN
cord-000248-zueoyesj	1073	28	in	in	IN
cord-000248-zueoyesj	1073	29	pelvic	pelvic	JJ
cord-000248-zueoyesj	1073	30	lymph	lymph	NN
cord-000248-zueoyesj	1073	31	nodes	node	NNS
cord-000248-zueoyesj	1073	32	predicts	predict	VBZ
cord-000248-zueoyesj	1073	33	the	the	DT
cord-000248-zueoyesj	1073	34	risk	risk	NN
cord-000248-zueoyesj	1073	35	of	of	IN
cord-000248-zueoyesj	1073	36	cancer	cancer	NN
cord-000248-zueoyesj	1073	37	progression	progression	NN
cord-000248-zueoyesj	1073	38	after	after	IN
cord-000248-zueoyesj	1073	39	radical	radical	JJ
cord-000248-zueoyesj	1073	40	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1073	41	Prostate	prostate	NN
cord-000248-zueoyesj	1073	42	cancer	cancer	NN
cord-000248-zueoyesj	1073	43	patients	patient	NNS
cord-000248-zueoyesj	1073	44	with	with	IN
cord-000248-zueoyesj	1073	45	lymph	lymph	NN
cord-000248-zueoyesj	1073	46	node	node	NN
cord-000248-zueoyesj	1073	47	metastasis	metastasis	NN
cord-000248-zueoyesj	1073	48	Radioisotope	radioisotope	NN
cord-000248-zueoyesj	1073	49	guided	guide	VBD
cord-000248-zueoyesj	1073	50	sentinel	sentinel	JJ
cord-000248-zueoyesj	1073	51	lymph	lymph	NN
cord-000248-zueoyesj	1073	52	node	node	NN
cord-000248-zueoyesj	1073	53	dissection	dissection	NN
cord-000248-zueoyesj	1073	54	in	in	IN
cord-000248-zueoyesj	1073	55	patients	patient	NNS
cord-000248-zueoyesj	1073	56	with	with	IN
cord-000248-zueoyesj	1073	57	localized	localized	JJ
cord-000248-zueoyesj	1073	58	prostate	prostate	NN
cord-000248-zueoyesj	1073	59	cancer	cancer	NN
cord-000248-zueoyesj	1073	60	:	:	:
cord-000248-zueoyesj	1073	61	results	result	NNS
cord-000248-zueoyesj	1073	62	of	of	IN
cord-000248-zueoyesj	1073	63	the	the	DT
cord-000248-zueoyesj	1073	64	first	first	JJ
cord-000248-zueoyesj	1073	65	100	100	CD
cord-000248-zueoyesj	1073	66	cases	case	NNS
cord-000248-zueoyesj	1073	67	Risk	risk	VBP
cord-000248-zueoyesj	1073	68	stratification	stratification	NN
cord-000248-zueoyesj	1073	69	for	for	IN
cord-000248-zueoyesj	1073	70	positive	positive	JJ
cord-000248-zueoyesj	1073	71	lymph	lymph	NN
cord-000248-zueoyesj	1073	72	nodes	node	NNS
cord-000248-zueoyesj	1073	73	in	in	IN
cord-000248-zueoyesj	1073	74	prostate	prostate	NN
cord-000248-zueoyesj	1073	75	cancer	cancer	NN
cord-000248-zueoyesj	1073	76	Use	use	NN
cord-000248-zueoyesj	1073	77	of	of	IN
cord-000248-zueoyesj	1073	78	preoperative	preoperative	JJ
cord-000248-zueoyesj	1073	79	plasma	plasma	NN
cord-000248-zueoyesj	1073	80	endoglin	endoglin	NN
cord-000248-zueoyesj	1073	81	for	for	IN
cord-000248-zueoyesj	1073	82	prediction	prediction	NN
cord-000248-zueoyesj	1073	83	of	of	IN
cord-000248-zueoyesj	1073	84	lymph	lymph	NN
cord-000248-zueoyesj	1073	85	node	node	NN
cord-000248-zueoyesj	1073	86	metastasis	metastasis	NN
cord-000248-zueoyesj	1073	87	in	in	IN
cord-000248-zueoyesj	1073	88	patients	patient	NNS
cord-000248-zueoyesj	1073	89	with	with	IN
cord-000248-zueoyesj	1073	90	clinically	clinically	RB
cord-000248-zueoyesj	1073	91	localized	localized	JJ
cord-000248-zueoyesj	1073	92	prostate	prostate	NN
cord-000248-zueoyesj	1073	93	cancer	cancer	NN
cord-000248-zueoyesj	1074	1	The	the	DT
cord-000248-zueoyesj	1074	2	rate	rate	NN
cord-000248-zueoyesj	1074	3	of	of	IN
cord-000248-zueoyesj	1074	4	lymph	lymph	NN
cord-000248-zueoyesj	1074	5	node	node	NN
cord-000248-zueoyesj	1074	6	invasion	invasion	NN
cord-000248-zueoyesj	1074	7	(	(	-LRB-
cord-000248-zueoyesj	1074	8	LNI	LNI	NNP
cord-000248-zueoyesj	1074	9	)	)	-RRB-
cord-000248-zueoyesj	1074	10	in	in	IN
cord-000248-zueoyesj	1074	11	men	man	NNS
cord-000248-zueoyesj	1074	12	with	with	IN
cord-000248-zueoyesj	1074	13	PSA	PSA	NNP
cord-000248-zueoyesj	1074	14	values	value	NNS
cord-000248-zueoyesj	1074	15	less	less	JJR
cord-000248-zueoyesj	1074	16	than	than	IN
cord-000248-zueoyesj	1074	17	10	10	CD
cord-000248-zueoyesj	1074	18	ng	ng	NN
cord-000248-zueoyesj	1074	19	/	/	SYM
cord-000248-zueoyesj	1074	20	ml	ml	CC
cord-000248-zueoyesj	1074	21	Pelvic	pelvic	JJ
cord-000248-zueoyesj	1074	22	lymph	lymph	NN
cord-000248-zueoyesj	1074	23	node	node	NN
cord-000248-zueoyesj	1074	24	irradiation	irradiation	NN
cord-000248-zueoyesj	1074	25	for	for	IN
cord-000248-zueoyesj	1074	26	prostate	prostate	NN
cord-000248-zueoyesj	1074	27	cancer	cancer	NN
cord-000248-zueoyesj	1074	28	:	:	:
cord-000248-zueoyesj	1074	29	who	who	WP
cord-000248-zueoyesj	1074	30	,	,	,
cord-000248-zueoyesj	1074	31	why	why	WRB
cord-000248-zueoyesj	1074	32	,	,	,
cord-000248-zueoyesj	1074	33	and	and	CC
cord-000248-zueoyesj	1074	34	when	when	WRB
cord-000248-zueoyesj	1074	35	?	?	.
cord-000248-zueoyesj	1075	1	The	the	DT
cord-000248-zueoyesj	1075	2	role	role	NN
cord-000248-zueoyesj	1075	3	of	of	IN
cord-000248-zueoyesj	1075	4	P501S	P501S	NNP
cord-000248-zueoyesj	1075	5	and	and	CC
cord-000248-zueoyesj	1075	6	PSA	PSA	NNP
cord-000248-zueoyesj	1075	7	in	in	IN
cord-000248-zueoyesj	1075	8	the	the	DT
cord-000248-zueoyesj	1075	9	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1075	10	of	of	IN
cord-000248-zueoyesj	1075	11	metastatic	metastatic	JJ
cord-000248-zueoyesj	1075	12	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1075	13	of	of	IN
cord-000248-zueoyesj	1075	14	the	the	DT
cord-000248-zueoyesj	1075	15	prostate	prostate	NN
cord-000248-zueoyesj	1075	16	Detection	detection	NN
cord-000248-zueoyesj	1075	17	and	and	CC
cord-000248-zueoyesj	1075	18	management	management	NN
cord-000248-zueoyesj	1075	19	of	of	IN
cord-000248-zueoyesj	1075	20	isolated	isolate	VBN
cord-000248-zueoyesj	1075	21	lymph	lymph	NN
cord-000248-zueoyesj	1075	22	node	node	NN
cord-000248-zueoyesj	1075	23	recurrence	recurrence	NN
cord-000248-zueoyesj	1075	24	in	in	IN
cord-000248-zueoyesj	1075	25	patients	patient	NNS
cord-000248-zueoyesj	1075	26	with	with	IN
cord-000248-zueoyesj	1075	27	PSA	PSA	NNP
cord-000248-zueoyesj	1075	28	relapse	relapse	NN
cord-000248-zueoyesj	1075	29	Significance	significance	NN
cord-000248-zueoyesj	1075	30	of	of	IN
cord-000248-zueoyesj	1075	31	micrometastases	micrometastase	NNS
cord-000248-zueoyesj	1075	32	in	in	IN
cord-000248-zueoyesj	1075	33	pelvic	pelvic	JJ
cord-000248-zueoyesj	1075	34	lymph	lymph	NN
cord-000248-zueoyesj	1075	35	nodes	node	NNS
cord-000248-zueoyesj	1075	36	detected	detect	VBN
cord-000248-zueoyesj	1075	37	by	by	IN
cord-000248-zueoyesj	1075	38	real	real	JJ
cord-000248-zueoyesj	1075	39	-	-	HYPH
cord-000248-zueoyesj	1075	40	time	time	NN
cord-000248-zueoyesj	1075	41	reverse	reverse	JJ
cord-000248-zueoyesj	1075	42	transcriptase	transcriptase	NN
cord-000248-zueoyesj	1075	43	polymerase	polymerase	NN
cord-000248-zueoyesj	1075	44	chain	chain	NN
cord-000248-zueoyesj	1075	45	reaction	reaction	NN
cord-000248-zueoyesj	1075	46	in	in	IN
cord-000248-zueoyesj	1075	47	patients	patient	NNS
cord-000248-zueoyesj	1075	48	with	with	IN
cord-000248-zueoyesj	1075	49	clinically	clinically	RB
cord-000248-zueoyesj	1075	50	localized	localized	JJ
cord-000248-zueoyesj	1075	51	prostate	prostate	NN
cord-000248-zueoyesj	1075	52	cancer	cancer	NN
cord-000248-zueoyesj	1075	53	undergoing	undergo	VBG
cord-000248-zueoyesj	1075	54	radical	radical	JJ
cord-000248-zueoyesj	1075	55	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1075	56	after	after	IN
cord-000248-zueoyesj	1075	57	neoadjuvant	neoadjuvant	JJ
cord-000248-zueoyesj	1075	58	hormonal	hormonal	JJ
cord-000248-zueoyesj	1075	59	therapy	therapy	NN
cord-000248-zueoyesj	1076	1	18F]fluorocholine	18f]fluorocholine	CD
cord-000248-zueoyesj	1076	2	PET	PET	NNP
cord-000248-zueoyesj	1076	3	/	/	SYM
cord-000248-zueoyesj	1076	4	CT	CT	NNP
cord-000248-zueoyesj	1076	5	imaging	imaging	NN
cord-000248-zueoyesj	1076	6	for	for	IN
cord-000248-zueoyesj	1076	7	the	the	DT
cord-000248-zueoyesj	1076	8	detection	detection	NN
cord-000248-zueoyesj	1076	9	of	of	IN
cord-000248-zueoyesj	1076	10	recurrent	recurrent	JJ
cord-000248-zueoyesj	1076	11	prostate	prostate	NN
cord-000248-zueoyesj	1076	12	cancer	cancer	NN
cord-000248-zueoyesj	1076	13	at	at	IN
cord-000248-zueoyesj	1076	14	PSA	PSA	NNP
cord-000248-zueoyesj	1076	15	relapse	relapse	NN
cord-000248-zueoyesj	1076	16	:	:	:
cord-000248-zueoyesj	1076	17	experience	experience	NN
cord-000248-zueoyesj	1076	18	in	in	IN
cord-000248-zueoyesj	1076	19	100	100	CD
cord-000248-zueoyesj	1076	20	consecutive	consecutive	JJ
cord-000248-zueoyesj	1076	21	patients	patient	NNS
cord-000248-zueoyesj	1076	22	Incidence	incidence	NN
cord-000248-zueoyesj	1076	23	of	of	IN
cord-000248-zueoyesj	1076	24	positive	positive	JJ
cord-000248-zueoyesj	1076	25	pelvic	pelvic	JJ
cord-000248-zueoyesj	1076	26	lymph	lymph	NN
cord-000248-zueoyesj	1076	27	nodes	node	NNS
cord-000248-zueoyesj	1076	28	in	in	IN
cord-000248-zueoyesj	1076	29	patients	patient	NNS
cord-000248-zueoyesj	1076	30	with	with	IN
cord-000248-zueoyesj	1076	31	prostate	prostate	NN
cord-000248-zueoyesj	1076	32	cancer	cancer	NN
cord-000248-zueoyesj	1076	33	,	,	,
cord-000248-zueoyesj	1076	34	a	a	DT
cord-000248-zueoyesj	1076	35	prostate	prostate	NN
cord-000248-zueoyesj	1076	36	-	-	HYPH
cord-000248-zueoyesj	1076	37	specific	specific	JJ
cord-000248-zueoyesj	1076	38	antigen	antigen	NN
cord-000248-zueoyesj	1076	39	(	(	-LRB-
cord-000248-zueoyesj	1076	40	PSA	PSA	NNP
cord-000248-zueoyesj	1076	41	)	)	-RRB-
cord-000248-zueoyesj	1076	42	level	level	NN
cord-000248-zueoyesj	1076	43	of	of	IN
cord-000248-zueoyesj	1076	44	,	,	,
cord-000248-zueoyesj	1076	45	or	or	CC
cord-000248-zueoyesj	1076	46	=	=	SYM
cord-000248-zueoyesj	1076	47	10	10	CD
cord-000248-zueoyesj	1076	48	ng	ng	NNP
cord-000248-zueoyesj	1076	49	/	/	SYM
cord-000248-zueoyesj	1076	50	mL	ml	NN
cord-000248-zueoyesj	1076	51	and	and	CC
cord-000248-zueoyesj	1076	52	biopsy	biopsy	NN
cord-000248-zueoyesj	1076	53	Gleason	Gleason	NNP
cord-000248-zueoyesj	1076	54	score	score	NN
cord-000248-zueoyesj	1076	55	of	of	IN
cord-000248-zueoyesj	1076	56	,	,	,
cord-000248-zueoyesj	1076	57	or	or	CC
cord-000248-zueoyesj	1076	58	=	=	SYM
cord-000248-zueoyesj	1076	59	6	6	CD
cord-000248-zueoyesj	1076	60	,	,	,
cord-000248-zueoyesj	1076	61	and	and	CC
cord-000248-zueoyesj	1076	62	their	-PRON-	PRP$
cord-000248-zueoyesj	1076	63	influence	influence	NN
cord-000248-zueoyesj	1076	64	on	on	IN
cord-000248-zueoyesj	1076	65	PSA	PSA	NNP
cord-000248-zueoyesj	1076	66	progression	progression	NN
cord-000248-zueoyesj	1076	67	-	-	HYPH
cord-000248-zueoyesj	1076	68	free	free	JJ
cord-000248-zueoyesj	1076	69	survival	survival	NN
cord-000248-zueoyesj	1076	70	after	after	IN
cord-000248-zueoyesj	1076	71	radical	radical	JJ
cord-000248-zueoyesj	1076	72	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1076	73	Histopathological	Histopathological	NNP
cord-000248-zueoyesj	1076	74	evaluation	evaluation	NN
cord-000248-zueoyesj	1076	75	of	of	IN
cord-000248-zueoyesj	1076	76	radical	radical	JJ
cord-000248-zueoyesj	1076	77	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1076	78	in	in	IN
cord-000248-zueoyesj	1076	79	the	the	DT
cord-000248-zueoyesj	1076	80	treatment	treatment	NN
cord-000248-zueoyesj	1076	81	of	of	IN
cord-000248-zueoyesj	1076	82	localized	localized	JJ
cord-000248-zueoyesj	1076	83	prostate	prostate	NN
cord-000248-zueoyesj	1076	84	cancer	cancer	NN
cord-000248-zueoyesj	1076	85	Disease	Disease	NNP
cord-000248-zueoyesj	1076	86	progression	progression	NN
cord-000248-zueoyesj	1076	87	and	and	CC
cord-000248-zueoyesj	1076	88	survival	survival	NN
cord-000248-zueoyesj	1076	89	in	in	IN
cord-000248-zueoyesj	1076	90	patients	patient	NNS
cord-000248-zueoyesj	1076	91	with	with	IN
cord-000248-zueoyesj	1076	92	prostate	prostate	NN
cord-000248-zueoyesj	1076	93	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1076	94	and	and	CC
cord-000248-zueoyesj	1076	95	positive	positive	JJ
cord-000248-zueoyesj	1076	96	lymph	lymph	NN
cord-000248-zueoyesj	1076	97	nodes	node	NNS
cord-000248-zueoyesj	1076	98	after	after	IN
cord-000248-zueoyesj	1076	99	radical	radical	JJ
cord-000248-zueoyesj	1076	100	retropubic	retropubic	JJ
cord-000248-zueoyesj	1076	101	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1077	1	Is	be	VBZ
cord-000248-zueoyesj	1077	2	pelvic	pelvic	JJ
cord-000248-zueoyesj	1077	3	lymph	lymph	NN
cord-000248-zueoyesj	1077	4	node	node	NN
cord-000248-zueoyesj	1077	5	dissection	dissection	NN
cord-000248-zueoyesj	1077	6	necessary	necessary	JJ
cord-000248-zueoyesj	1077	7	in	in	IN
cord-000248-zueoyesj	1077	8	patients	patient	NNS
cord-000248-zueoyesj	1077	9	with	with	IN
cord-000248-zueoyesj	1077	10	a	a	DT
cord-000248-zueoyesj	1077	11	serum	serum	NN
cord-000248-zueoyesj	1077	12	PSA,10ng	psa,10ng	NN
cord-000248-zueoyesj	1078	1	/ml	/ml	NFP
cord-000248-zueoyesj	1078	2	undergoing	undergo	VBG
cord-000248-zueoyesj	1078	3	radical	radical	JJ
cord-000248-zueoyesj	1078	4	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1078	5	for	for	IN
cord-000248-zueoyesj	1078	6	prostate	prostate	NN
cord-000248-zueoyesj	1078	7	cancer	cancer	NN
cord-000248-zueoyesj	1078	8	?	?	.
cord-000248-zueoyesj	1079	1	Usefulness	usefulness	NN
cord-000248-zueoyesj	1079	2	of	of	IN
cord-000248-zueoyesj	1079	3	the	the	DT
cord-000248-zueoyesj	1079	4	nadir	nadir	JJ
cord-000248-zueoyesj	1079	5	value	value	NN
cord-000248-zueoyesj	1079	6	of	of	IN
cord-000248-zueoyesj	1079	7	serum	serum	NN
cord-000248-zueoyesj	1079	8	prostate	prostate	NN
cord-000248-zueoyesj	1079	9	-	-	HYPH
cord-000248-zueoyesj	1079	10	specific	specific	JJ
cord-000248-zueoyesj	1079	11	antigen	antigen	NN
cord-000248-zueoyesj	1079	12	measured	measure	VBN
cord-000248-zueoyesj	1079	13	by	by	IN
cord-000248-zueoyesj	1079	14	an	an	DT
cord-000248-zueoyesj	1079	15	ultrasensitive	ultrasensitive	JJ
cord-000248-zueoyesj	1079	16	assay	assay	NN
cord-000248-zueoyesj	1079	17	as	as	IN
cord-000248-zueoyesj	1079	18	a	a	DT
cord-000248-zueoyesj	1079	19	predictor	predictor	NN
cord-000248-zueoyesj	1079	20	of	of	IN
cord-000248-zueoyesj	1079	21	biochemical	biochemical	JJ
cord-000248-zueoyesj	1079	22	recurrence	recurrence	NN
cord-000248-zueoyesj	1079	23	after	after	IN
cord-000248-zueoyesj	1079	24	radical	radical	JJ
cord-000248-zueoyesj	1079	25	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1079	26	for	for	IN
cord-000248-zueoyesj	1079	27	clinically	clinically	RB
cord-000248-zueoyesj	1079	28	localized	localized	JJ
cord-000248-zueoyesj	1079	29	prostate	prostate	NN
cord-000248-zueoyesj	1079	30	cancer	cancer	NN
cord-000248-zueoyesj	1079	31	Lymphovascular	Lymphovascular	NNP
cord-000248-zueoyesj	1079	32	invasion	invasion	NN
cord-000248-zueoyesj	1079	33	is	be	VBZ
cord-000248-zueoyesj	1079	34	an	an	DT
cord-000248-zueoyesj	1079	35	independent	independent	JJ
cord-000248-zueoyesj	1079	36	prognostic	prognostic	JJ
cord-000248-zueoyesj	1079	37	factor	factor	NN
cord-000248-zueoyesj	1079	38	in	in	IN
cord-000248-zueoyesj	1079	39	prostatic	prostatic	JJ
cord-000248-zueoyesj	1079	40	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1079	41	Lymph	lymph	NN
cord-000248-zueoyesj	1079	42	node	node	NN
cord-000248-zueoyesj	1079	43	staging	stage	VBG
cord-000248-zueoyesj	1079	44	in	in	IN
cord-000248-zueoyesj	1079	45	prostatic	prostatic	JJ
cord-000248-zueoyesj	1079	46	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1079	47	revisited	revisit	VBD
cord-000248-zueoyesj	1079	48	Prostate	prostate	JJ
cord-000248-zueoyesj	1079	49	specific	specific	JJ
cord-000248-zueoyesj	1079	50	antigen	antigen	NN
cord-000248-zueoyesj	1079	51	progression	progression	NN
cord-000248-zueoyesj	1079	52	in	in	IN
cord-000248-zueoyesj	1079	53	men	man	NNS
cord-000248-zueoyesj	1079	54	with	with	IN
cord-000248-zueoyesj	1079	55	lymph	lymph	NN
cord-000248-zueoyesj	1079	56	node	node	NN
cord-000248-zueoyesj	1079	57	metastases	metastasis	NNS
cord-000248-zueoyesj	1079	58	following	follow	VBG
cord-000248-zueoyesj	1079	59	radical	radical	JJ
cord-000248-zueoyesj	1079	60	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1079	61	:	:	:
cord-000248-zueoyesj	1079	62	results	result	NNS
cord-000248-zueoyesj	1079	63	of	of	IN
cord-000248-zueoyesj	1079	64	long	long	JJ
cord-000248-zueoyesj	1079	65	-	-	HYPH
cord-000248-zueoyesj	1079	66	term	term	NN
cord-000248-zueoyesj	1079	67	followup	followup	JJ
cord-000248-zueoyesj	1079	68	Natural	natural	JJ
cord-000248-zueoyesj	1079	69	history	history	NN
cord-000248-zueoyesj	1079	70	of	of	IN
cord-000248-zueoyesj	1079	71	disease	disease	NN
cord-000248-zueoyesj	1079	72	progression	progression	NN
cord-000248-zueoyesj	1079	73	in	in	IN
cord-000248-zueoyesj	1079	74	patients	patient	NNS
cord-000248-zueoyesj	1079	75	who	who	WP
cord-000248-zueoyesj	1079	76	fail	fail	VBP
cord-000248-zueoyesj	1079	77	to	to	TO
cord-000248-zueoyesj	1079	78	achieve	achieve	VB
cord-000248-zueoyesj	1079	79	an	an	DT
cord-000248-zueoyesj	1079	80	undetectable	undetectable	JJ
cord-000248-zueoyesj	1079	81	prostate	prostate	NN
cord-000248-zueoyesj	1079	82	-	-	HYPH
cord-000248-zueoyesj	1079	83	specific	specific	JJ
cord-000248-zueoyesj	1079	84	antigen	antigen	NN
cord-000248-zueoyesj	1079	85	level	level	NN
cord-000248-zueoyesj	1079	86	after	after	IN
cord-000248-zueoyesj	1079	87	undergoing	undergo	VBG
cord-000248-zueoyesj	1079	88	radical	radical	JJ
cord-000248-zueoyesj	1079	89	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1080	1	The	the	DT
cord-000248-zueoyesj	1080	2	value	value	NN
cord-000248-zueoyesj	1080	3	of	of	IN
cord-000248-zueoyesj	1080	4	prostate	prostate	NN
cord-000248-zueoyesj	1080	5	-	-	HYPH
cord-000248-zueoyesj	1080	6	specific	specific	JJ
cord-000248-zueoyesj	1080	7	antigen	antigen	NN
cord-000248-zueoyesj	1080	8	levels	level	NNS
cord-000248-zueoyesj	1080	9	in	in	IN
cord-000248-zueoyesj	1080	10	pelvic	pelvic	JJ
cord-000248-zueoyesj	1080	11	lymph	lymph	NN
cord-000248-zueoyesj	1080	12	nodes	node	NNS
cord-000248-zueoyesj	1080	13	for	for	IN
cord-000248-zueoyesj	1080	14	diagnosing	diagnose	VBG
cord-000248-zueoyesj	1080	15	metastatic	metastatic	JJ
cord-000248-zueoyesj	1080	16	spread	spread	NN
cord-000248-zueoyesj	1080	17	of	of	IN
cord-000248-zueoyesj	1080	18	prostate	prostate	NN
cord-000248-zueoyesj	1080	19	cancer	cancer	NN
cord-000248-zueoyesj	1080	20	Pelvic	Pelvic	NNP
cord-000248-zueoyesj	1080	21	lymphadenectomy	lymphadenectomy	NN
cord-000248-zueoyesj	1080	22	can	can	MD
cord-000248-zueoyesj	1080	23	be	be	VB
cord-000248-zueoyesj	1080	24	omitted	omit	VBN
cord-000248-zueoyesj	1080	25	in	in	IN
cord-000248-zueoyesj	1080	26	selected	select	VBN
cord-000248-zueoyesj	1080	27	patients	patient	NNS
cord-000248-zueoyesj	1080	28	with	with	IN
cord-000248-zueoyesj	1080	29	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1080	30	of	of	IN
cord-000248-zueoyesj	1080	31	the	the	DT
cord-000248-zueoyesj	1080	32	prostate	prostate	NN
cord-000248-zueoyesj	1080	33	:	:	:
cord-000248-zueoyesj	1080	34	development	development	NN
cord-000248-zueoyesj	1080	35	of	of	IN
cord-000248-zueoyesj	1080	36	a	a	DT
cord-000248-zueoyesj	1080	37	system	system	NN
cord-000248-zueoyesj	1080	38	of	of	IN
cord-000248-zueoyesj	1080	39	patient	patient	NN
cord-000248-zueoyesj	1080	40	selection	selection	NN
cord-000248-zueoyesj	1081	1	The	the	DT
cord-000248-zueoyesj	1081	2	gene	gene	NN
cord-000248-zueoyesj	1081	3	expression	expression	NN
cord-000248-zueoyesj	1081	4	signatures	signature	NNS
cord-000248-zueoyesj	1081	5	of	of	IN
cord-000248-zueoyesj	1081	6	melanoma	melanoma	NN
cord-000248-zueoyesj	1081	7	progression	progression	NN
cord-000248-zueoyesj	1082	1	The	the	DT
cord-000248-zueoyesj	1082	2	p53	p53	NN
cord-000248-zueoyesj	1082	3	family	family	NN
cord-000248-zueoyesj	1082	4	:	:	:
cord-000248-zueoyesj	1082	5	same	same	JJ
cord-000248-zueoyesj	1082	6	response	response	NN
cord-000248-zueoyesj	1082	7	,	,	,
cord-000248-zueoyesj	1082	8	different	different	JJ
cord-000248-zueoyesj	1082	9	signals	signal	NNS
cord-000248-zueoyesj	1082	10	P53	P53	NNP
cord-000248-zueoyesj	1082	11	family	family	NN
cord-000248-zueoyesj	1082	12	activities	activity	NNS
cord-000248-zueoyesj	1082	13	in	in	IN
cord-000248-zueoyesj	1082	14	development	development	NN
cord-000248-zueoyesj	1082	15	and	and	CC
cord-000248-zueoyesj	1082	16	cancer	cancer	NN
cord-000248-zueoyesj	1082	17	:	:	:
cord-000248-zueoyesj	1083	1	relationship	relationship	NN
cord-000248-zueoyesj	1083	2	to	to	IN
cord-000248-zueoyesj	1083	3	melanocyte	melanocyte	NN
cord-000248-zueoyesj	1083	4	and	and	CC
cord-000248-zueoyesj	1083	5	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	1083	6	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1083	7	Contribution	Contribution	NNP
cord-000248-zueoyesj	1083	8	of	of	IN
cord-000248-zueoyesj	1083	9	p53	p53	NN
cord-000248-zueoyesj	1083	10	,	,	,
cord-000248-zueoyesj	1083	11	p63	p63	CD
cord-000248-zueoyesj	1083	12	,	,	,
cord-000248-zueoyesj	1083	13	and	and	CC
cord-000248-zueoyesj	1083	14	p73	p73	NN
cord-000248-zueoyesj	1083	15	to	to	IN
cord-000248-zueoyesj	1083	16	the	the	DT
cord-000248-zueoyesj	1083	17	developmental	developmental	JJ
cord-000248-zueoyesj	1083	18	diseases	disease	NNS
cord-000248-zueoyesj	1083	19	and	and	CC
cord-000248-zueoyesj	1083	20	cancer	cancer	NN
cord-000248-zueoyesj	1083	21	and	and	CC
cord-000248-zueoyesj	1083	22	p63	p63	NN
cord-000248-zueoyesj	1083	23	:	:	:
cord-000248-zueoyesj	1083	24	why	why	WRB
cord-000248-zueoyesj	1083	25	do	do	VBP
cord-000248-zueoyesj	1083	26	we	-PRON-	PRP
cord-000248-zueoyesj	1083	27	still	still	RB
cord-000248-zueoyesj	1083	28	need	need	VB
cord-000248-zueoyesj	1083	29	them	-PRON-	PRP
cord-000248-zueoyesj	1083	30	?	?	.
cord-000248-zueoyesj	1084	1	TP63	TP63	NNP
cord-000248-zueoyesj	1084	2	gene	gene	NN
cord-000248-zueoyesj	1084	3	in	in	IN
cord-000248-zueoyesj	1084	4	stress	stress	NN
cord-000248-zueoyesj	1084	5	response	response	NN
cord-000248-zueoyesj	1084	6	and	and	CC
cord-000248-zueoyesj	1084	7	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1084	8	:	:	:
cord-000248-zueoyesj	1084	9	a	a	DT
cord-000248-zueoyesj	1084	10	broader	broad	JJR
cord-000248-zueoyesj	1084	11	role	role	NN
cord-000248-zueoyesj	1084	12	than	than	IN
cord-000248-zueoyesj	1084	13	expected	expect	VBN
cord-000248-zueoyesj	1084	14	Properties	property	NNS
cord-000248-zueoyesj	1084	15	of	of	IN
cord-000248-zueoyesj	1084	16	the	the	DT
cord-000248-zueoyesj	1084	17	six	six	CD
cord-000248-zueoyesj	1084	18	isoforms	isoform	NNS
cord-000248-zueoyesj	1084	19	of	of	IN
cord-000248-zueoyesj	1084	20	p63	p63	CD
cord-000248-zueoyesj	1084	21	:	:	:
cord-000248-zueoyesj	1084	22	p53-like	p53-like	IN
cord-000248-zueoyesj	1084	23	regulation	regulation	NN
cord-000248-zueoyesj	1084	24	in	in	IN
cord-000248-zueoyesj	1084	25	response	response	NN
cord-000248-zueoyesj	1084	26	to	to	IN
cord-000248-zueoyesj	1084	27	genotoxic	genotoxic	JJ
cord-000248-zueoyesj	1084	28	stress	stress	NN
cord-000248-zueoyesj	1084	29	and	and	CC
cord-000248-zueoyesj	1084	30	cross	cross	NN
cord-000248-zueoyesj	1084	31	talk	talk	NN
cord-000248-zueoyesj	1084	32	with	with	IN
cord-000248-zueoyesj	1084	33	DeltaNp73	DeltaNp73	NNP
cord-000248-zueoyesj	1084	34	)	)	-RRB-
cord-000248-zueoyesj	1085	1	miR-203	miR-203	NNP
cord-000248-zueoyesj	1085	2	represses	repress	VBZ
cord-000248-zueoyesj	1085	3	'	'	``
cord-000248-zueoyesj	1085	4	stemness	stemness	NN
cord-000248-zueoyesj	1085	5	'	'	''
cord-000248-zueoyesj	1085	6	by	by	IN
cord-000248-zueoyesj	1085	7	repressing	repress	VBG
cord-000248-zueoyesj	1085	8	DeltaNp63	deltanp63	JJ
cord-000248-zueoyesj	1085	9	Melanocyte	Melanocyte	NNP
cord-000248-zueoyesj	1085	10	and	and	CC
cord-000248-zueoyesj	1085	11	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	1085	12	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1085	13	:	:	:
cord-000248-zueoyesj	1086	1	p53	p53	NN
cord-000248-zueoyesj	1086	2	family	family	NN
cord-000248-zueoyesj	1086	3	protein	protein	NN
cord-000248-zueoyesj	1086	4	activities	activity	NNS
cord-000248-zueoyesj	1086	5	and	and	CC
cord-000248-zueoyesj	1086	6	intersecting	intersect	VBG
cord-000248-zueoyesj	1086	7	mRNA	mrna	NN
cord-000248-zueoyesj	1086	8	expression	expression	NN
cord-000248-zueoyesj	1086	9	profiles	profile	NNS
cord-000248-zueoyesj	1087	1	Comparative	comparative	JJ
cord-000248-zueoyesj	1087	2	study	study	NN
cord-000248-zueoyesj	1087	3	of	of	IN
cord-000248-zueoyesj	1087	4	p63	p63	CD
cord-000248-zueoyesj	1087	5	and	and	CC
cord-000248-zueoyesj	1087	6	p53	p53	NN
cord-000248-zueoyesj	1087	7	expression	expression	NN
cord-000248-zueoyesj	1087	8	in	in	IN
cord-000248-zueoyesj	1087	9	tissue	tissue	NN
cord-000248-zueoyesj	1087	10	microarrays	microarray	NNS
cord-000248-zueoyesj	1087	11	of	of	IN
cord-000248-zueoyesj	1087	12	malignant	malignant	JJ
cord-000248-zueoyesj	1087	13	melanomas	melanoma	NNS
cord-000248-zueoyesj	1087	14	Connecting	connect	VBG
cord-000248-zueoyesj	1087	15	p63	p63	CD
cord-000248-zueoyesj	1087	16	to	to	IN
cord-000248-zueoyesj	1087	17	cellular	cellular	JJ
cord-000248-zueoyesj	1087	18	proliferation	proliferation	NN
cord-000248-zueoyesj	1087	19	:	:	:
cord-000248-zueoyesj	1088	1	the	the	DT
cord-000248-zueoyesj	1088	2	example	example	NN
cord-000248-zueoyesj	1088	3	of	of	IN
cord-000248-zueoyesj	1088	4	the	the	DT
cord-000248-zueoyesj	1088	5	adenosine	adenosine	NN
cord-000248-zueoyesj	1088	6	deaminase	deaminase	NNP
cord-000248-zueoyesj	1088	7	target	target	NN
cord-000248-zueoyesj	1088	8	gene	gene	NN
cord-000248-zueoyesj	1088	9	Adenosine	adenosine	NN
cord-000248-zueoyesj	1088	10	deamination	deamination	NN
cord-000248-zueoyesj	1088	11	sustains	sustain	VBZ
cord-000248-zueoyesj	1088	12	dendritic	dendritic	JJ
cord-000248-zueoyesj	1088	13	cell	cell	NN
cord-000248-zueoyesj	1088	14	activation	activation	NN
cord-000248-zueoyesj	1088	15	in	in	IN
cord-000248-zueoyesj	1088	16	inflammation	inflammation	NN
cord-000248-zueoyesj	1088	17	CK2-site	ck2-site	NN
cord-000248-zueoyesj	1088	18	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	1088	19	of	of	IN
cord-000248-zueoyesj	1088	20	p53	p53	NN
cord-000248-zueoyesj	1088	21	is	be	VBZ
cord-000248-zueoyesj	1088	22	induced	induce	VBN
cord-000248-zueoyesj	1088	23	in	in	IN
cord-000248-zueoyesj	1088	24	DeltaNp63	DeltaNp63	NNP
cord-000248-zueoyesj	1088	25	expressing	express	VBG
cord-000248-zueoyesj	1088	26	basal	basal	NN
cord-000248-zueoyesj	1088	27	stem	stem	NN
cord-000248-zueoyesj	1088	28	cells	cell	NNS
cord-000248-zueoyesj	1088	29	in	in	IN
cord-000248-zueoyesj	1088	30	UVB	uvb	NN
cord-000248-zueoyesj	1088	31	irradiated	irradiate	VBD
cord-000248-zueoyesj	1088	32	human	human	JJ
cord-000248-zueoyesj	1088	33	skin	skin	NN
cord-000248-zueoyesj	1088	34	Adenosine	adenosine	NN
cord-000248-zueoyesj	1088	35	deaminase	deaminase	NN
cord-000248-zueoyesj	1088	36	activity	activity	NN
cord-000248-zueoyesj	1088	37	in	in	IN
cord-000248-zueoyesj	1088	38	the	the	DT
cord-000248-zueoyesj	1088	39	serum	serum	NN
cord-000248-zueoyesj	1088	40	and	and	CC
cord-000248-zueoyesj	1088	41	malignant	malignant	JJ
cord-000248-zueoyesj	1088	42	tumors	tumor	NNS
cord-000248-zueoyesj	1088	43	of	of	IN
cord-000248-zueoyesj	1088	44	breast	breast	NN
cord-000248-zueoyesj	1088	45	cancer	cancer	NN
cord-000248-zueoyesj	1088	46	:	:	:
cord-000248-zueoyesj	1088	47	the	the	DT
cord-000248-zueoyesj	1088	48	assessment	assessment	NN
cord-000248-zueoyesj	1088	49	of	of	IN
cord-000248-zueoyesj	1088	50	isoenzyme	isoenzyme	NNPS
cord-000248-zueoyesj	1088	51	ADA1	ADA1	NNP
cord-000248-zueoyesj	1088	52	and	and	CC
cord-000248-zueoyesj	1088	53	ADA2	ADA2	NNP
cord-000248-zueoyesj	1088	54	activities	activity	NNS
cord-000248-zueoyesj	1088	55	Adenosine	Adenosine	NNP
cord-000248-zueoyesj	1088	56	deaminase	deaminase	NN
cord-000248-zueoyesj	1088	57	,	,	,
cord-000248-zueoyesj	1088	58	xanthine	xanthine	NN
cord-000248-zueoyesj	1088	59	oxidase	oxidase	NN
cord-000248-zueoyesj	1088	60	,	,	,
cord-000248-zueoyesj	1088	61	superoxide	superoxide	NN
cord-000248-zueoyesj	1088	62	dismutase	dismutase	NN
cord-000248-zueoyesj	1088	63	,	,	,
cord-000248-zueoyesj	1088	64	glutathione	glutathione	NN
cord-000248-zueoyesj	1088	65	peroxidase	peroxidase	NN
cord-000248-zueoyesj	1088	66	activities	activity	NNS
cord-000248-zueoyesj	1088	67	and	and	CC
cord-000248-zueoyesj	1088	68	malondialdehyde	malondialdehyde	JJ
cord-000248-zueoyesj	1088	69	levels	level	NNS
cord-000248-zueoyesj	1088	70	in	in	IN
cord-000248-zueoyesj	1088	71	the	the	DT
cord-000248-zueoyesj	1088	72	sera	sera	NNP
cord-000248-zueoyesj	1088	73	of	of	IN
cord-000248-zueoyesj	1088	74	patients	patient	NNS
cord-000248-zueoyesj	1088	75	with	with	IN
cord-000248-zueoyesj	1088	76	head	head	NN
cord-000248-zueoyesj	1088	77	and	and	CC
cord-000248-zueoyesj	1088	78	neck	neck	NN
cord-000248-zueoyesj	1088	79	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1088	80	Activities	activity	NNS
cord-000248-zueoyesj	1088	81	of	of	IN
cord-000248-zueoyesj	1088	82	adenosine	adenosine	NN
cord-000248-zueoyesj	1088	83	deaminase	deaminase	NN
cord-000248-zueoyesj	1088	84	and	and	CC
cord-000248-zueoyesj	1088	85	59-nucleotidase	59-nucleotidase	CD
cord-000248-zueoyesj	1088	86	in	in	IN
cord-000248-zueoyesj	1088	87	cancerous	cancerous	JJ
cord-000248-zueoyesj	1088	88	and	and	CC
cord-000248-zueoyesj	1088	89	noncancerous	noncancerous	JJ
cord-000248-zueoyesj	1088	90	human	human	JJ
cord-000248-zueoyesj	1088	91	colorectal	colorectal	NN
cord-000248-zueoyesj	1088	92	tissues	tissue	NNS
cord-000248-zueoyesj	1089	1	Serum	serum	NN
cord-000248-zueoyesj	1089	2	adenosine	adenosine	NN
cord-000248-zueoyesj	1089	3	deaminase	deaminase	NN
cord-000248-zueoyesj	1089	4	and	and	CC
cord-000248-zueoyesj	1089	5	arylsulphatase	arylsulphatase	NNP
cord-000248-zueoyesj	1089	6	A	A	NNP
cord-000248-zueoyesj	1089	7	as	as	IN
cord-000248-zueoyesj	1089	8	an	an	DT
cord-000248-zueoyesj	1089	9	index	index	NN
cord-000248-zueoyesj	1089	10	of	of	IN
cord-000248-zueoyesj	1089	11	early	early	JJ
cord-000248-zueoyesj	1089	12	infiltration	infiltration	NN
cord-000248-zueoyesj	1089	13	of	of	IN
cord-000248-zueoyesj	1089	14	central	central	JJ
cord-000248-zueoyesj	1089	15	nervous	nervous	JJ
cord-000248-zueoyesj	1089	16	system	system	NN
cord-000248-zueoyesj	1089	17	in	in	IN
cord-000248-zueoyesj	1089	18	acute	acute	JJ
cord-000248-zueoyesj	1089	19	lymphoblastic	lymphoblastic	NN
cord-000248-zueoyesj	1090	1	leukemia	leukemia	NN
cord-000248-zueoyesj	1090	2	Serum	Serum	NNP
cord-000248-zueoyesj	1090	3	adenosine	adenosine	NN
cord-000248-zueoyesj	1090	4	deaminase	deaminase	NN
cord-000248-zueoyesj	1090	5	and	and	CC
cord-000248-zueoyesj	1090	6	total	total	JJ
cord-000248-zueoyesj	1090	7	superoxide	superoxide	NN
cord-000248-zueoyesj	1090	8	dismutase	dismutase	NN
cord-000248-zueoyesj	1090	9	activities	activity	NNS
cord-000248-zueoyesj	1090	10	before	before	IN
cord-000248-zueoyesj	1090	11	and	and	CC
cord-000248-zueoyesj	1090	12	after	after	IN
cord-000248-zueoyesj	1090	13	surgical	surgical	JJ
cord-000248-zueoyesj	1090	14	removal	removal	NN
cord-000248-zueoyesj	1090	15	of	of	IN
cord-000248-zueoyesj	1090	16	cancerous	cancerous	JJ
cord-000248-zueoyesj	1090	17	laryngeal	laryngeal	NN
cord-000248-zueoyesj	1090	18	tissue	tissue	NN
cord-000248-zueoyesj	1090	19	Dipeptide	Dipeptide	NNP
cord-000248-zueoyesj	1090	20	proline	proline	NN
cord-000248-zueoyesj	1090	21	diphenyl	diphenyl	FW
cord-000248-zueoyesj	1090	22	phosphonates	phosphonate	NNS
cord-000248-zueoyesj	1090	23	are	be	VBP
cord-000248-zueoyesj	1090	24	potent	potent	JJ
cord-000248-zueoyesj	1090	25	,	,	,
cord-000248-zueoyesj	1090	26	irreversible	irreversible	JJ
cord-000248-zueoyesj	1090	27	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	1090	28	of	of	IN
cord-000248-zueoyesj	1090	29	seprase	seprase	NNP
cord-000248-zueoyesj	1090	30	(	(	-LRB-
cord-000248-zueoyesj	1090	31	FAPalpha	FAPalpha	NNP
cord-000248-zueoyesj	1090	32	)	)	-RRB-
cord-000248-zueoyesj	1091	1	Dipeptidyl	dipeptidyl	JJ
cord-000248-zueoyesj	1091	2	peptidase	peptidase	NN
cord-000248-zueoyesj	1091	3	inhibits	inhibit	VBZ
cord-000248-zueoyesj	1091	4	malignant	malignant	JJ
cord-000248-zueoyesj	1091	5	phenotype	phenotype	NN
cord-000248-zueoyesj	1091	6	of	of	IN
cord-000248-zueoyesj	1091	7	prostate	prostate	NN
cord-000248-zueoyesj	1091	8	cancer	cancer	NN
cord-000248-zueoyesj	1091	9	cells	cell	NNS
cord-000248-zueoyesj	1091	10	by	by	IN
cord-000248-zueoyesj	1091	11	blocking	block	VBG
cord-000248-zueoyesj	1091	12	basic	basic	JJ
cord-000248-zueoyesj	1091	13	fibroblast	fibroblast	NN
cord-000248-zueoyesj	1091	14	growth	growth	NN
cord-000248-zueoyesj	1091	15	factor	factor	NN
cord-000248-zueoyesj	1091	16	signaling	signal	VBG
cord-000248-zueoyesj	1092	1	pathway	pathway	NNP
cord-000248-zueoyesj	1092	2	Loss	Loss	NNP
cord-000248-zueoyesj	1092	3	of	of	IN
cord-000248-zueoyesj	1092	4	dipeptidyl	dipeptidyl	JJ
cord-000248-zueoyesj	1092	5	peptidase	peptidase	NN
cord-000248-zueoyesj	1092	6	IV	IV	NNP
cord-000248-zueoyesj	1092	7	immunostaining	immunostaining	NN
cord-000248-zueoyesj	1092	8	discriminates	discriminate	VBZ
cord-000248-zueoyesj	1092	9	malignant	malignant	JJ
cord-000248-zueoyesj	1092	10	melanomas	melanoma	NNS
cord-000248-zueoyesj	1092	11	from	from	IN
cord-000248-zueoyesj	1092	12	deep	deep	JJ
cord-000248-zueoyesj	1092	13	penetrating	penetrate	VBG
cord-000248-zueoyesj	1092	14	nevi	nevus	NNS
cord-000248-zueoyesj	1092	15	A	a	DT
cord-000248-zueoyesj	1092	16	marker	marker	NN
cord-000248-zueoyesj	1092	17	for	for	IN
cord-000248-zueoyesj	1092	18	neoplastic	neoplastic	JJ
cord-000248-zueoyesj	1092	19	progression	progression	NN
cord-000248-zueoyesj	1092	20	of	of	IN
cord-000248-zueoyesj	1092	21	human	human	JJ
cord-000248-zueoyesj	1092	22	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1092	23	is	be	VBZ
cord-000248-zueoyesj	1092	24	a	a	DT
cord-000248-zueoyesj	1092	25	cell	cell	NN
cord-000248-zueoyesj	1092	26	surface	surface	NN
cord-000248-zueoyesj	1092	27	ectopeptidase	ectopeptidase	NNP
cord-000248-zueoyesj	1092	28	Expression	Expression	NNP
cord-000248-zueoyesj	1092	29	of	of	IN
cord-000248-zueoyesj	1092	30	CD26	CD26	NNP
cord-000248-zueoyesj	1092	31	/	/	SYM
cord-000248-zueoyesj	1092	32	dipeptidyl	dipeptidyl	JJ
cord-000248-zueoyesj	1092	33	-	-	HYPH
cord-000248-zueoyesj	1092	34	peptidase	peptidase	NN
cord-000248-zueoyesj	1092	35	IV	IV	NNP
cord-000248-zueoyesj	1092	36	in	in	IN
cord-000248-zueoyesj	1092	37	benign	benign	JJ
cord-000248-zueoyesj	1092	38	and	and	CC
cord-000248-zueoyesj	1092	39	malignant	malignant	JJ
cord-000248-zueoyesj	1092	40	pigment	pigment	NN
cord-000248-zueoyesj	1092	41	-	-	HYPH
cord-000248-zueoyesj	1092	42	cell	cell	NN
cord-000248-zueoyesj	1092	43	lesions	lesion	NNS
cord-000248-zueoyesj	1092	44	of	of	IN
cord-000248-zueoyesj	1092	45	the	the	DT
cord-000248-zueoyesj	1092	46	skin	skin	NN
cord-000248-zueoyesj	1092	47	Adenosine	adenosine	NN
cord-000248-zueoyesj	1092	48	downregulates	downregulate	VBZ
cord-000248-zueoyesj	1092	49	DPPIV	DPPIV	NNP
cord-000248-zueoyesj	1092	50	on	on	IN
cord-000248-zueoyesj	1092	51	HT-29	HT-29	NNP
cord-000248-zueoyesj	1092	52	colon	colon	NN
cord-000248-zueoyesj	1092	53	cancer	cancer	NN
cord-000248-zueoyesj	1092	54	cells	cell	NNS
cord-000248-zueoyesj	1092	55	by	by	IN
cord-000248-zueoyesj	1092	56	stimulating	stimulate	VBG
cord-000248-zueoyesj	1092	57	protein	protein	NN
cord-000248-zueoyesj	1092	58	tyrosine	tyrosine	NN
cord-000248-zueoyesj	1092	59	phosphatases	phosphatase	NNS
cord-000248-zueoyesj	1092	60	and	and	CC
cord-000248-zueoyesj	1092	61	reducing	reduce	VBG
cord-000248-zueoyesj	1092	62	ERK1/2	ERK1/2	NNP
cord-000248-zueoyesj	1092	63	activity	activity	NN
cord-000248-zueoyesj	1092	64	via	via	IN
cord-000248-zueoyesj	1092	65	a	a	DT
cord-000248-zueoyesj	1092	66	novel	novel	JJ
cord-000248-zueoyesj	1092	67	pathway	pathway	NN
cord-000248-zueoyesj	1092	68	Adenosine	adenosine	NN
cord-000248-zueoyesj	1092	69	down	down	RB
cord-000248-zueoyesj	1092	70	-	-	:
cord-000248-zueoyesj	1092	71	regulates	regulate	VBZ
cord-000248-zueoyesj	1092	72	the	the	DT
cord-000248-zueoyesj	1092	73	surface	surface	NN
cord-000248-zueoyesj	1092	74	expression	expression	NN
cord-000248-zueoyesj	1092	75	of	of	IN
cord-000248-zueoyesj	1092	76	dipeptidyl	dipeptidyl	JJ
cord-000248-zueoyesj	1092	77	peptidase	peptidase	NN
cord-000248-zueoyesj	1092	78	IV	IV	NNP
cord-000248-zueoyesj	1092	79	on	on	IN
cord-000248-zueoyesj	1092	80	HT-29	HT-29	NNP
cord-000248-zueoyesj	1092	81	human	human	JJ
cord-000248-zueoyesj	1092	82	colorectal	colorectal	JJ
cord-000248-zueoyesj	1092	83	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1092	84	cells	cell	NNS
cord-000248-zueoyesj	1092	85	:	:	:
cord-000248-zueoyesj	1092	86	implications	implication	NNS
cord-000248-zueoyesj	1092	87	for	for	IN
cord-000248-zueoyesj	1092	88	cancer	cancer	NN
cord-000248-zueoyesj	1092	89	cell	cell	NN
cord-000248-zueoyesj	1092	90	behavior	behavior	NN
cord-000248-zueoyesj	1092	91	Differential	differential	JJ
cord-000248-zueoyesj	1092	92	regulation	regulation	NN
cord-000248-zueoyesj	1092	93	of	of	IN
cord-000248-zueoyesj	1092	94	centrosome	centrosome	NN
cord-000248-zueoyesj	1092	95	integrity	integrity	NN
cord-000248-zueoyesj	1092	96	by	by	IN
cord-000248-zueoyesj	1092	97	DNA	dna	NN
cord-000248-zueoyesj	1092	98	damage	damage	NN
cord-000248-zueoyesj	1092	99	response	response	NN
cord-000248-zueoyesj	1092	100	proteins	protein	NNS
cord-000248-zueoyesj	1092	101	Genomic	genomic	JJ
cord-000248-zueoyesj	1092	102	models	model	NNS
cord-000248-zueoyesj	1092	103	of	of	IN
cord-000248-zueoyesj	1092	104	metastatic	metastatic	JJ
cord-000248-zueoyesj	1092	105	cancer	cancer	NN
cord-000248-zueoyesj	1092	106	:	:	:
cord-000248-zueoyesj	1092	107	functional	functional	JJ
cord-000248-zueoyesj	1092	108	analysis	analysis	NN
cord-000248-zueoyesj	1092	109	of	of	IN
cord-000248-zueoyesj	1092	110	death	death	NN
cord-000248-zueoyesj	1092	111	-	-	HYPH
cord-000248-zueoyesj	1092	112	from	from	IN
cord-000248-zueoyesj	1092	113	-	-	HYPH
cord-000248-zueoyesj	1092	114	cancer	cancer	NN
cord-000248-zueoyesj	1092	115	signature	signature	NN
cord-000248-zueoyesj	1092	116	genes	gene	NNS
cord-000248-zueoyesj	1092	117	reveals	reveal	VBZ
cord-000248-zueoyesj	1092	118	aneuploid	aneuploid	JJ
cord-000248-zueoyesj	1092	119	,	,	,
cord-000248-zueoyesj	1092	120	anoikis	anoikis	NN
cord-000248-zueoyesj	1092	121	-	-	HYPH
cord-000248-zueoyesj	1092	122	resistant	resistant	JJ
cord-000248-zueoyesj	1092	123	,	,	,
cord-000248-zueoyesj	1092	124	metastasis	metastasis	NN
cord-000248-zueoyesj	1092	125	-	-	HYPH
cord-000248-zueoyesj	1092	126	enabling	enable	VBG
cord-000248-zueoyesj	1092	127	phenotype	phenotype	NN
cord-000248-zueoyesj	1092	128	with	with	IN
cord-000248-zueoyesj	1092	129	altered	altered	JJ
cord-000248-zueoyesj	1092	130	cell	cell	NN
cord-000248-zueoyesj	1092	131	cycle	cycle	NN
cord-000248-zueoyesj	1092	132	control	control	NN
cord-000248-zueoyesj	1092	133	and	and	CC
cord-000248-zueoyesj	1092	134	activated	activate	VBN
cord-000248-zueoyesj	1092	135	Polycomb	Polycomb	NNP
cord-000248-zueoyesj	1092	136	Group	Group	NNP
cord-000248-zueoyesj	1092	137	(	(	-LRB-
cord-000248-zueoyesj	1092	138	PcG	PcG	NNP
cord-000248-zueoyesj	1092	139	)	)	-RRB-
cord-000248-zueoyesj	1092	140	protein	protein	NN
cord-000248-zueoyesj	1092	141	chromatin	chromatin	NN
cord-000248-zueoyesj	1092	142	silencing	silence	VBG
cord-000248-zueoyesj	1092	143	pathway	pathway	NN
cord-000248-zueoyesj	1092	144	Expression	expression	NN
cord-000248-zueoyesj	1092	145	patterns	pattern	NNS
cord-000248-zueoyesj	1092	146	of	of	IN
cord-000248-zueoyesj	1092	147	polo	polo	NN
cord-000248-zueoyesj	1092	148	-	-	HYPH
cord-000248-zueoyesj	1092	149	like	like	JJ
cord-000248-zueoyesj	1092	150	kinase	kinase	NN
cord-000248-zueoyesj	1092	151	1	1	CD
cord-000248-zueoyesj	1092	152	in	in	IN
cord-000248-zueoyesj	1092	153	human	human	JJ
cord-000248-zueoyesj	1092	154	gastric	gastric	JJ
cord-000248-zueoyesj	1092	155	cancer	cancer	NN
cord-000248-zueoyesj	1092	156	Overexpression	Overexpression	NNP
cord-000248-zueoyesj	1092	157	of	of	IN
cord-000248-zueoyesj	1092	158	polo	polo	NN
cord-000248-zueoyesj	1092	159	-	-	HYPH
cord-000248-zueoyesj	1092	160	like	like	JJ
cord-000248-zueoyesj	1092	161	kinase	kinase	NN
cord-000248-zueoyesj	1092	162	1	1	CD
cord-000248-zueoyesj	1093	1	(	(	-LRB-
cord-000248-zueoyesj	1093	2	PLK1	PLK1	NNP
cord-000248-zueoyesj	1093	3	)	)	-RRB-
cord-000248-zueoyesj	1093	4	and	and	CC
cord-000248-zueoyesj	1093	5	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1093	6	instability	instability	NN
cord-000248-zueoyesj	1093	7	in	in	IN
cord-000248-zueoyesj	1093	8	bladder	bladder	NN
cord-000248-zueoyesj	1093	9	cancer	cancer	NN
cord-000248-zueoyesj	1093	10	Polo	Polo	NNP
cord-000248-zueoyesj	1093	11	-	-	HYPH
cord-000248-zueoyesj	1093	12	like	like	JJ
cord-000248-zueoyesj	1093	13	kinase	kinase	NN
cord-000248-zueoyesj	1093	14	1	1	CD
cord-000248-zueoyesj	1093	15	expression	expression	NN
cord-000248-zueoyesj	1093	16	is	be	VBZ
cord-000248-zueoyesj	1093	17	a	a	DT
cord-000248-zueoyesj	1093	18	prognostic	prognostic	JJ
cord-000248-zueoyesj	1093	19	factor	factor	NN
cord-000248-zueoyesj	1093	20	in	in	IN
cord-000248-zueoyesj	1093	21	human	human	JJ
cord-000248-zueoyesj	1093	22	colon	colon	NN
cord-000248-zueoyesj	1093	23	cancer	cancer	NN
cord-000248-zueoyesj	1093	24	Polo	Polo	NNP
cord-000248-zueoyesj	1093	25	-	-	HYPH
cord-000248-zueoyesj	1093	26	like	like	JJ
cord-000248-zueoyesj	1093	27	kinase	kinase	NN
cord-000248-zueoyesj	1093	28	1	1	CD
cord-000248-zueoyesj	1093	29	(	(	-LRB-
cord-000248-zueoyesj	1093	30	PLK1	PLK1	NNP
cord-000248-zueoyesj	1093	31	)	)	-RRB-
cord-000248-zueoyesj	1093	32	is	be	VBZ
cord-000248-zueoyesj	1093	33	overexpressed	overexpresse	VBN
cord-000248-zueoyesj	1093	34	in	in	IN
cord-000248-zueoyesj	1093	35	primary	primary	JJ
cord-000248-zueoyesj	1093	36	colorectal	colorectal	JJ
cord-000248-zueoyesj	1093	37	cancers	cancer	NNS
cord-000248-zueoyesj	1094	1	Aberrant	aberrant	JJ
cord-000248-zueoyesj	1094	2	Polo	Polo	NNP
cord-000248-zueoyesj	1094	3	-	-	HYPH
cord-000248-zueoyesj	1094	4	like	like	JJ
cord-000248-zueoyesj	1094	5	kinase	kinase	NN
cord-000248-zueoyesj	1094	6	1-Cdc25A	1-cdc25a	CD
cord-000248-zueoyesj	1094	7	pathway	pathway	NN
cord-000248-zueoyesj	1094	8	in	in	IN
cord-000248-zueoyesj	1094	9	metastatic	metastatic	JJ
cord-000248-zueoyesj	1094	10	hepatocellular	hepatocellular	JJ
cord-000248-zueoyesj	1094	11	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1094	12	Polo	polo	NN
cord-000248-zueoyesj	1094	13	-	-	HYPH
cord-000248-zueoyesj	1094	14	like	like	JJ
cord-000248-zueoyesj	1094	15	kinase	kinase	NN
cord-000248-zueoyesj	1094	16	1	1	CD
cord-000248-zueoyesj	1094	17	expression	expression	NN
cord-000248-zueoyesj	1094	18	in	in	IN
cord-000248-zueoyesj	1094	19	medullary	medullary	JJ
cord-000248-zueoyesj	1094	20	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1094	21	of	of	IN
cord-000248-zueoyesj	1094	22	the	the	DT
cord-000248-zueoyesj	1094	23	thyroid	thyroid	NN
cord-000248-zueoyesj	1094	24	:	:	:
cord-000248-zueoyesj	1095	1	its	-PRON-	PRP$
cord-000248-zueoyesj	1095	2	relationship	relationship	NN
cord-000248-zueoyesj	1095	3	with	with	IN
cord-000248-zueoyesj	1095	4	clinicopathological	clinicopathological	NNP
cord-000248-zueoyesj	1095	5	features	feature	VBZ
cord-000248-zueoyesj	1095	6	Silencing	silencing	NN
cord-000248-zueoyesj	1095	7	of	of	IN
cord-000248-zueoyesj	1095	8	polo	polo	NN
cord-000248-zueoyesj	1095	9	-	-	HYPH
cord-000248-zueoyesj	1095	10	like	like	JJ
cord-000248-zueoyesj	1095	11	kinase	kinase	NN
cord-000248-zueoyesj	1095	12	(	(	-LRB-
cord-000248-zueoyesj	1095	13	Plk	Plk	NNP
cord-000248-zueoyesj	1095	14	)	)	-RRB-
cord-000248-zueoyesj	1095	15	1	1	CD
cord-000248-zueoyesj	1095	16	via	via	IN
cord-000248-zueoyesj	1095	17	siRNA	siRNA	NNP
cord-000248-zueoyesj	1095	18	causes	cause	VBZ
cord-000248-zueoyesj	1095	19	inhibition	inhibition	NN
cord-000248-zueoyesj	1095	20	of	of	IN
cord-000248-zueoyesj	1095	21	growth	growth	NN
cord-000248-zueoyesj	1095	22	and	and	CC
cord-000248-zueoyesj	1095	23	induction	induction	NN
cord-000248-zueoyesj	1095	24	of	of	IN
cord-000248-zueoyesj	1095	25	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1095	26	in	in	IN
cord-000248-zueoyesj	1095	27	human	human	JJ
cord-000248-zueoyesj	1095	28	esophageal	esophageal	JJ
cord-000248-zueoyesj	1095	29	cancer	cancer	NN
cord-000248-zueoyesj	1095	30	cells	cell	NNS
cord-000248-zueoyesj	1095	31	Identification	identification	NN
cord-000248-zueoyesj	1095	32	of	of	IN
cord-000248-zueoyesj	1095	33	human	human	JJ
cord-000248-zueoyesj	1095	34	polo	polo	NN
cord-000248-zueoyesj	1095	35	-	-	HYPH
cord-000248-zueoyesj	1095	36	like	like	JJ
cord-000248-zueoyesj	1095	37	kinase	kinase	NN
cord-000248-zueoyesj	1095	38	1	1	CD
cord-000248-zueoyesj	1095	39	as	as	IN
cord-000248-zueoyesj	1095	40	a	a	DT
cord-000248-zueoyesj	1095	41	potential	potential	JJ
cord-000248-zueoyesj	1095	42	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1095	43	target	target	NN
cord-000248-zueoyesj	1095	44	in	in	IN
cord-000248-zueoyesj	1095	45	pancreatic	pancreatic	JJ
cord-000248-zueoyesj	1095	46	cancer	cancer	NN
cord-000248-zueoyesj	1095	47	Robust	robust	JJ
cord-000248-zueoyesj	1095	48	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1095	49	of	of	IN
cord-000248-zueoyesj	1095	50	non	non	JJ
cord-000248-zueoyesj	1095	51	-	-	JJ
cord-000248-zueoyesj	1095	52	Hodgkin	Hodgkin	NNP
cord-000248-zueoyesj	1095	53	lymphoma	lymphoma	NN
cord-000248-zueoyesj	1095	54	phenotypes	phenotype	NNS
cord-000248-zueoyesj	1095	55	validated	validate	VBN
cord-000248-zueoyesj	1095	56	on	on	IN
cord-000248-zueoyesj	1095	57	gene	gene	NN
cord-000248-zueoyesj	1095	58	expression	expression	NN
cord-000248-zueoyesj	1095	59	data	datum	NNS
cord-000248-zueoyesj	1095	60	from	from	IN
cord-000248-zueoyesj	1095	61	different	different	JJ
cord-000248-zueoyesj	1095	62	laboratories	laboratory	NNS
cord-000248-zueoyesj	1095	63	Polo	Polo	NNP
cord-000248-zueoyesj	1095	64	-	-	HYPH
cord-000248-zueoyesj	1095	65	like	like	JJ
cord-000248-zueoyesj	1095	66	kinase	kinase	NN
cord-000248-zueoyesj	1095	67	isoforms	isoform	NNS
cord-000248-zueoyesj	1095	68	in	in	IN
cord-000248-zueoyesj	1095	69	breast	breast	NN
cord-000248-zueoyesj	1095	70	cancer	cancer	NN
cord-000248-zueoyesj	1095	71	:	:	:
cord-000248-zueoyesj	1095	72	expression	expression	NN
cord-000248-zueoyesj	1095	73	patterns	pattern	NNS
cord-000248-zueoyesj	1095	74	and	and	CC
cord-000248-zueoyesj	1095	75	prognostic	prognostic	JJ
cord-000248-zueoyesj	1095	76	implications	implication	NNS
cord-000248-zueoyesj	1095	77	Expression	expression	NN
cord-000248-zueoyesj	1095	78	of	of	IN
cord-000248-zueoyesj	1095	79	polo	polo	NN
cord-000248-zueoyesj	1095	80	-	-	HYPH
cord-000248-zueoyesj	1095	81	like	like	JJ
cord-000248-zueoyesj	1095	82	kinase	kinase	NN
cord-000248-zueoyesj	1095	83	(	(	-LRB-
cord-000248-zueoyesj	1095	84	PLK1	PLK1	NNP
cord-000248-zueoyesj	1095	85	)	)	-RRB-
cord-000248-zueoyesj	1096	1	in	in	IN
cord-000248-zueoyesj	1096	2	thin	thin	JJ
cord-000248-zueoyesj	1096	3	melanomas	melanoma	NNS
cord-000248-zueoyesj	1096	4	:	:	:
cord-000248-zueoyesj	1096	5	a	a	DT
cord-000248-zueoyesj	1096	6	novel	novel	JJ
cord-000248-zueoyesj	1096	7	marker	marker	NN
cord-000248-zueoyesj	1096	8	of	of	IN
cord-000248-zueoyesj	1096	9	metastatic	metastatic	JJ
cord-000248-zueoyesj	1096	10	disease	disease	NN
cord-000248-zueoyesj	1096	11	Biodistribution	Biodistribution	NNP
cord-000248-zueoyesj	1096	12	and	and	CC
cord-000248-zueoyesj	1096	13	kinetics	kinetic	NNS
cord-000248-zueoyesj	1096	14	of	of	IN
cord-000248-zueoyesj	1096	15	the	the	DT
cord-000248-zueoyesj	1096	16	novel	novel	JJ
cord-000248-zueoyesj	1096	17	selective	selective	JJ
cord-000248-zueoyesj	1096	18	oncolytic	oncolytic	JJ
cord-000248-zueoyesj	1096	19	adenovirus	adenovirus	NN
cord-000248-zueoyesj	1096	20	M1	M1	NNP
cord-000248-zueoyesj	1096	21	after	after	IN
cord-000248-zueoyesj	1096	22	systemic	systemic	JJ
cord-000248-zueoyesj	1096	23	administration	administration	NN
cord-000248-zueoyesj	1096	24	Confirming	confirm	VBG
cord-000248-zueoyesj	1096	25	the	the	DT
cord-000248-zueoyesj	1096	26	RNAi	RNAi	NNS
cord-000248-zueoyesj	1096	27	-	-	HYPH
cord-000248-zueoyesj	1096	28	mediated	mediate	VBN
cord-000248-zueoyesj	1096	29	mechanism	mechanism	NN
cord-000248-zueoyesj	1096	30	of	of	IN
cord-000248-zueoyesj	1096	31	action	action	NN
cord-000248-zueoyesj	1096	32	of	of	IN
cord-000248-zueoyesj	1096	33	siRNA	siRNA	NNP
cord-000248-zueoyesj	1096	34	-	-	HYPH
cord-000248-zueoyesj	1096	35	based	base	VBN
cord-000248-zueoyesj	1096	36	cancer	cancer	NN
cord-000248-zueoyesj	1096	37	therapeutics	therapeutic	NNS
cord-000248-zueoyesj	1096	38	in	in	IN
cord-000248-zueoyesj	1096	39	mice	mouse	NNS
cord-000248-zueoyesj	1096	40	Normal	normal	JJ
cord-000248-zueoyesj	1096	41	cells	cell	NNS
cord-000248-zueoyesj	1096	42	,	,	,
cord-000248-zueoyesj	1096	43	but	but	CC
cord-000248-zueoyesj	1096	44	not	not	RB
cord-000248-zueoyesj	1096	45	cancer	cancer	NN
cord-000248-zueoyesj	1096	46	cells	cell	NNS
cord-000248-zueoyesj	1096	47	,	,	,
cord-000248-zueoyesj	1096	48	survive	survive	VBP
cord-000248-zueoyesj	1096	49	severe	severe	JJ
cord-000248-zueoyesj	1096	50	Plk1	plk1	JJ
cord-000248-zueoyesj	1096	51	depletion	depletion	NN
cord-000248-zueoyesj	1096	52	Polo	polo	NN
cord-000248-zueoyesj	1096	53	-	-	HYPH
cord-000248-zueoyesj	1096	54	like	like	JJ
cord-000248-zueoyesj	1096	55	kinase	kinase	NN
cord-000248-zueoyesj	1096	56	(	(	-LRB-
cord-000248-zueoyesj	1096	57	Plk)1	Plk)1	NNS
cord-000248-zueoyesj	1096	58	depletion	depletion	NN
cord-000248-zueoyesj	1096	59	induces	induce	VBZ
cord-000248-zueoyesj	1096	60	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1096	61	in	in	IN
cord-000248-zueoyesj	1096	62	cancer	cancer	NN
cord-000248-zueoyesj	1096	63	cells	cell	NNS
cord-000248-zueoyesj	1096	64	Effect	effect	NN
cord-000248-zueoyesj	1096	65	of	of	IN
cord-000248-zueoyesj	1096	66	antisense	antisense	NNP
cord-000248-zueoyesj	1096	67	RNA	RNA	NNP
cord-000248-zueoyesj	1096	68	targeting	target	VBG
cord-000248-zueoyesj	1096	69	Polo	Polo	NNP
cord-000248-zueoyesj	1096	70	-	-	HYPH
cord-000248-zueoyesj	1096	71	like	like	JJ
cord-000248-zueoyesj	1096	72	kinase	kinase	NN
cord-000248-zueoyesj	1096	73	1	1	CD
cord-000248-zueoyesj	1096	74	on	on	IN
cord-000248-zueoyesj	1096	75	cell	cell	NN
cord-000248-zueoyesj	1096	76	growth	growth	NN
cord-000248-zueoyesj	1096	77	in	in	IN
cord-000248-zueoyesj	1096	78	A549	a549	JJ
cord-000248-zueoyesj	1096	79	lung	lung	NN
cord-000248-zueoyesj	1096	80	cancer	cancer	NN
cord-000248-zueoyesj	1096	81	cells	cell	NNS
cord-000248-zueoyesj	1097	1	A	a	DT
cord-000248-zueoyesj	1097	2	panel	panel	NN
cord-000248-zueoyesj	1097	3	of	of	IN
cord-000248-zueoyesj	1097	4	isogenic	isogenic	JJ
cord-000248-zueoyesj	1097	5	human	human	JJ
cord-000248-zueoyesj	1097	6	cancer	cancer	NN
cord-000248-zueoyesj	1097	7	cells	cell	NNS
cord-000248-zueoyesj	1097	8	suggests	suggest	VBZ
cord-000248-zueoyesj	1097	9	a	a	DT
cord-000248-zueoyesj	1097	10	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1097	11	approach	approach	NN
cord-000248-zueoyesj	1097	12	for	for	IN
cord-000248-zueoyesj	1097	13	cancers	cancer	NNS
cord-000248-zueoyesj	1097	14	with	with	IN
cord-000248-zueoyesj	1097	15	inactivated	inactivate	VBN
cord-000248-zueoyesj	1097	16	p53	p53	NN
cord-000248-zueoyesj	1097	17	Plk1	Plk1	NNP
cord-000248-zueoyesj	1097	18	depletion	depletion	NN
cord-000248-zueoyesj	1097	19	in	in	IN
cord-000248-zueoyesj	1097	20	nontransformed	nontransforme	VBN
cord-000248-zueoyesj	1097	21	diploid	diploid	JJ
cord-000248-zueoyesj	1097	22	cells	cell	NNS
cord-000248-zueoyesj	1097	23	activates	activate	VBZ
cord-000248-zueoyesj	1097	24	the	the	DT
cord-000248-zueoyesj	1097	25	DNA	dna	NN
cord-000248-zueoyesj	1097	26	-	-	HYPH
cord-000248-zueoyesj	1097	27	damage	damage	NN
cord-000248-zueoyesj	1097	28	checkpoint	checkpoint	NN
cord-000248-zueoyesj	1097	29	GATHER	gather	VB
cord-000248-zueoyesj	1097	30	:	:	:
cord-000248-zueoyesj	1097	31	a	a	DT
cord-000248-zueoyesj	1097	32	systems	system	NNS
cord-000248-zueoyesj	1097	33	approach	approach	NN
cord-000248-zueoyesj	1097	34	to	to	IN
cord-000248-zueoyesj	1097	35	interpreting	interpret	VBG
cord-000248-zueoyesj	1097	36	genomic	genomic	JJ
cord-000248-zueoyesj	1097	37	signatures	signature	NNS
cord-000248-zueoyesj	1097	38	Profiler	profiler	NN
cord-000248-zueoyesj	1097	39	-	-	,
cord-000248-zueoyesj	1097	40	a	a	DT
cord-000248-zueoyesj	1097	41	webbased	webbased	JJ
cord-000248-zueoyesj	1097	42	toolset	toolset	NN
cord-000248-zueoyesj	1097	43	for	for	IN
cord-000248-zueoyesj	1097	44	functional	functional	JJ
cord-000248-zueoyesj	1097	45	profiling	profiling	NN
cord-000248-zueoyesj	1097	46	of	of	IN
cord-000248-zueoyesj	1097	47	gene	gene	NN
cord-000248-zueoyesj	1097	48	lists	list	NNS
cord-000248-zueoyesj	1097	49	from	from	IN
cord-000248-zueoyesj	1097	50	large	large	JJ
cord-000248-zueoyesj	1097	51	-	-	HYPH
cord-000248-zueoyesj	1097	52	scale	scale	NN
cord-000248-zueoyesj	1097	53	experiments	experiment	NNS
cord-000248-zueoyesj	1097	54	Cryptic	cryptic	JJ
cord-000248-zueoyesj	1097	55	splicing	splicing	NN
cord-000248-zueoyesj	1097	56	at	at	IN
cord-000248-zueoyesj	1097	57	a	a	DT
cord-000248-zueoyesj	1097	58	non	non	JJ
cord-000248-zueoyesj	1097	59	-	-	JJ
cord-000248-zueoyesj	1097	60	consensus	consensus	JJ
cord-000248-zueoyesj	1097	61	splice	splice	NN
cord-000248-zueoyesj	1097	62	-	-	HYPH
cord-000248-zueoyesj	1097	63	donor	donor	NN
cord-000248-zueoyesj	1097	64	in	in	IN
cord-000248-zueoyesj	1097	65	a	a	DT
cord-000248-zueoyesj	1097	66	patient	patient	NN
cord-000248-zueoyesj	1097	67	with	with	IN
cord-000248-zueoyesj	1097	68	a	a	DT
cord-000248-zueoyesj	1097	69	novel	novel	JJ
cord-000248-zueoyesj	1097	70	mutation	mutation	NN
cord-000248-zueoyesj	1097	71	in	in	IN
cord-000248-zueoyesj	1097	72	the	the	DT
cord-000248-zueoyesj	1097	73	plakophilin-1	plakophilin-1	NNP
cord-000248-zueoyesj	1097	74	gene	gene	NN
cord-000248-zueoyesj	1097	75	Genetic	genetic	JJ
cord-000248-zueoyesj	1097	76	diseases	disease	NNS
cord-000248-zueoyesj	1097	77	of	of	IN
cord-000248-zueoyesj	1097	78	junctions	junction	NNS
cord-000248-zueoyesj	1098	1	Ectodermal	Ectodermal	NNP
cord-000248-zueoyesj	1098	2	dysplasia	dysplasia	NN
cord-000248-zueoyesj	1098	3	-	-	HYPH
cord-000248-zueoyesj	1098	4	skin	skin	NN
cord-000248-zueoyesj	1098	5	fragility	fragility	NN
cord-000248-zueoyesj	1098	6	syndrome	syndrome	NN
cord-000248-zueoyesj	1098	7	resulting	result	VBG
cord-000248-zueoyesj	1098	8	from	from	IN
cord-000248-zueoyesj	1098	9	a	a	DT
cord-000248-zueoyesj	1098	10	new	new	JJ
cord-000248-zueoyesj	1098	11	homozygous	homozygous	JJ
cord-000248-zueoyesj	1098	12	mutation	mutation	NN
cord-000248-zueoyesj	1098	13	,	,	,
cord-000248-zueoyesj	1098	14	888delC	888delc	CD
cord-000248-zueoyesj	1098	15	,	,	,
cord-000248-zueoyesj	1098	16	in	in	IN
cord-000248-zueoyesj	1098	17	the	the	DT
cord-000248-zueoyesj	1098	18	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	1098	19	protein	protein	NN
cord-000248-zueoyesj	1098	20	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1098	21	1	1	CD
cord-000248-zueoyesj	1098	22	Clinical	clinical	JJ
cord-000248-zueoyesj	1098	23	and	and	CC
cord-000248-zueoyesj	1098	24	molecular	molecular	JJ
cord-000248-zueoyesj	1098	25	significance	significance	NN
cord-000248-zueoyesj	1098	26	of	of	IN
cord-000248-zueoyesj	1098	27	splice	splice	NN
cord-000248-zueoyesj	1098	28	site	site	NN
cord-000248-zueoyesj	1098	29	mutations	mutation	NNS
cord-000248-zueoyesj	1098	30	in	in	IN
cord-000248-zueoyesj	1098	31	the	the	DT
cord-000248-zueoyesj	1098	32	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1098	33	1	1	CD
cord-000248-zueoyesj	1098	34	gene	gene	NN
cord-000248-zueoyesj	1098	35	in	in	IN
cord-000248-zueoyesj	1098	36	patients	patient	NNS
cord-000248-zueoyesj	1098	37	with	with	IN
cord-000248-zueoyesj	1098	38	ectodermal	ectodermal	NNP
cord-000248-zueoyesj	1098	39	dysplasiaskin	dysplasiaskin	NNP
cord-000248-zueoyesj	1098	40	fragility	fragility	NN
cord-000248-zueoyesj	1098	41	syndrome	syndrome	NN
cord-000248-zueoyesj	1099	1	Inherited	inherit	VBN
cord-000248-zueoyesj	1099	2	disorders	disorder	NNS
cord-000248-zueoyesj	1099	3	of	of	IN
cord-000248-zueoyesj	1099	4	desmosomes	desmosome	NNS
cord-000248-zueoyesj	1100	1	Hereditary	hereditary	JJ
cord-000248-zueoyesj	1100	2	mucoepithelial	mucoepithelial	JJ
cord-000248-zueoyesj	1100	3	dysplasia	dysplasia	NN
cord-000248-zueoyesj	1100	4	:	:	:
cord-000248-zueoyesj	1101	1	clinical	clinical	JJ
cord-000248-zueoyesj	1101	2	,	,	,
cord-000248-zueoyesj	1101	3	ultrastructural	ultrastructural	JJ
cord-000248-zueoyesj	1101	4	and	and	CC
cord-000248-zueoyesj	1101	5	genetic	genetic	JJ
cord-000248-zueoyesj	1101	6	study	study	NN
cord-000248-zueoyesj	1101	7	of	of	IN
cord-000248-zueoyesj	1101	8	eight	eight	CD
cord-000248-zueoyesj	1101	9	patients	patient	NNS
cord-000248-zueoyesj	1101	10	and	and	CC
cord-000248-zueoyesj	1101	11	literature	literature	NN
cord-000248-zueoyesj	1101	12	review	review	NN
cord-000248-zueoyesj	1101	13	Homozygous	Homozygous	NNP
cord-000248-zueoyesj	1101	14	splice	splice	NN
cord-000248-zueoyesj	1101	15	site	site	NN
cord-000248-zueoyesj	1101	16	mutations	mutation	NNS
cord-000248-zueoyesj	1101	17	in	in	IN
cord-000248-zueoyesj	1101	18	PKP1	PKP1	NNP
cord-000248-zueoyesj	1101	19	result	result	NN
cord-000248-zueoyesj	1101	20	in	in	IN
cord-000248-zueoyesj	1101	21	loss	loss	NN
cord-000248-zueoyesj	1101	22	of	of	IN
cord-000248-zueoyesj	1101	23	epidermal	epidermal	JJ
cord-000248-zueoyesj	1101	24	plakophilin	plakophilin	NN
cord-000248-zueoyesj	1101	25	1	1	CD
cord-000248-zueoyesj	1101	26	expression	expression	NN
cord-000248-zueoyesj	1101	27	and	and	CC
cord-000248-zueoyesj	1101	28	underlie	underlie	VBP
cord-000248-zueoyesj	1101	29	ectodermal	ectodermal	JJ
cord-000248-zueoyesj	1101	30	dysplasia	dysplasia	NN
cord-000248-zueoyesj	1101	31	/	/	SYM
cord-000248-zueoyesj	1101	32	skin	skin	NN
cord-000248-zueoyesj	1101	33	fragility	fragility	NN
cord-000248-zueoyesj	1101	34	syndrome	syndrome	NN
cord-000248-zueoyesj	1101	35	in	in	IN
cord-000248-zueoyesj	1101	36	two	two	CD
cord-000248-zueoyesj	1101	37	consanguineous	consanguineous	JJ
cord-000248-zueoyesj	1101	38	families	family	NNS
cord-000248-zueoyesj	1101	39	Assessment	Assessment	NNP
cord-000248-zueoyesj	1101	40	of	of	IN
cord-000248-zueoyesj	1101	41	splice	splice	NN
cord-000248-zueoyesj	1101	42	variant	variant	NN
cord-000248-zueoyesj	1101	43	-	-	HYPH
cord-000248-zueoyesj	1101	44	specific	specific	JJ
cord-000248-zueoyesj	1101	45	functions	function	NNS
cord-000248-zueoyesj	1101	46	of	of	IN
cord-000248-zueoyesj	1101	47	desmocollin	desmocollin	NN
cord-000248-zueoyesj	1101	48	1	1	CD
cord-000248-zueoyesj	1101	49	in	in	IN
cord-000248-zueoyesj	1101	50	the	the	DT
cord-000248-zueoyesj	1101	51	skin	skin	NN
cord-000248-zueoyesj	1101	52	Desmosomes	desmosome	NNS
cord-000248-zueoyesj	1101	53	:	:	:
cord-000248-zueoyesj	1101	54	structure	structure	NN
cord-000248-zueoyesj	1101	55	and	and	CC
cord-000248-zueoyesj	1101	56	function	function	NN
cord-000248-zueoyesj	1101	57	in	in	IN
cord-000248-zueoyesj	1101	58	normal	normal	JJ
cord-000248-zueoyesj	1101	59	and	and	CC
cord-000248-zueoyesj	1101	60	diseased	diseased	JJ
cord-000248-zueoyesj	1101	61	epidermis	epidermis	NN
cord-000248-zueoyesj	1101	62	Genomic	genomic	JJ
cord-000248-zueoyesj	1101	63	amplification	amplification	NN
cord-000248-zueoyesj	1101	64	of	of	IN
cord-000248-zueoyesj	1101	65	the	the	DT
cord-000248-zueoyesj	1101	66	human	human	JJ
cord-000248-zueoyesj	1101	67	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1101	68	1	1	CD
cord-000248-zueoyesj	1101	69	gene	gene	NN
cord-000248-zueoyesj	1101	70	and	and	CC
cord-000248-zueoyesj	1101	71	detection	detection	NN
cord-000248-zueoyesj	1101	72	of	of	IN
cord-000248-zueoyesj	1101	73	a	a	DT
cord-000248-zueoyesj	1101	74	new	new	JJ
cord-000248-zueoyesj	1101	75	mutation	mutation	NN
cord-000248-zueoyesj	1101	76	in	in	IN
cord-000248-zueoyesj	1101	77	ectodermal	ectodermal	JJ
cord-000248-zueoyesj	1101	78	dysplasia	dysplasia	NN
cord-000248-zueoyesj	1101	79	/	/	SYM
cord-000248-zueoyesj	1101	80	skin	skin	NN
cord-000248-zueoyesj	1101	81	fragility	fragility	NN
cord-000248-zueoyesj	1101	82	syndrome	syndrome	NN
cord-000248-zueoyesj	1101	83	Genomic	Genomic	NNP
cord-000248-zueoyesj	1101	84	organization	organization	NN
cord-000248-zueoyesj	1101	85	and	and	CC
cord-000248-zueoyesj	1101	86	amplification	amplification	NN
cord-000248-zueoyesj	1101	87	of	of	IN
cord-000248-zueoyesj	1101	88	the	the	DT
cord-000248-zueoyesj	1101	89	human	human	JJ
cord-000248-zueoyesj	1101	90	plakoglobin	plakoglobin	NNP
cord-000248-zueoyesj	1101	91	gene	gene	NN
cord-000248-zueoyesj	1101	92	(	(	-LRB-
cord-000248-zueoyesj	1101	93	JUP	JUP	NNP
cord-000248-zueoyesj	1101	94	)	)	-RRB-
cord-000248-zueoyesj	1101	95	Skin	skin	NN
cord-000248-zueoyesj	1101	96	fragility	fragility	NN
cord-000248-zueoyesj	1101	97	and	and	CC
cord-000248-zueoyesj	1101	98	hypohidrotic	hypohidrotic	JJ
cord-000248-zueoyesj	1101	99	ectodermal	ectodermal	NN
cord-000248-zueoyesj	1101	100	dysplasia	dysplasia	NN
cord-000248-zueoyesj	1101	101	resulting	result	VBG
cord-000248-zueoyesj	1101	102	from	from	IN
cord-000248-zueoyesj	1101	103	ablation	ablation	NN
cord-000248-zueoyesj	1101	104	of	of	IN
cord-000248-zueoyesj	1101	105	plakophilin	plakophilin	NN
cord-000248-zueoyesj	1101	106	1	1	CD
cord-000248-zueoyesj	1101	107	Hereditary	hereditary	JJ
cord-000248-zueoyesj	1101	108	diseases	disease	NNS
cord-000248-zueoyesj	1101	109	of	of	IN
cord-000248-zueoyesj	1101	110	desmosomes	desmosome	NNS
cord-000248-zueoyesj	1101	111	A	a	DT
cord-000248-zueoyesj	1101	112	novel	novel	JJ
cord-000248-zueoyesj	1101	113	genodermatosis	genodermatosis	NN
cord-000248-zueoyesj	1101	114	caused	cause	VBN
cord-000248-zueoyesj	1101	115	by	by	IN
cord-000248-zueoyesj	1101	116	mutations	mutation	NNS
cord-000248-zueoyesj	1101	117	in	in	IN
cord-000248-zueoyesj	1101	118	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1101	119	1	1	CD
cord-000248-zueoyesj	1101	120	,	,	,
cord-000248-zueoyesj	1102	1	a	a	DT
cord-000248-zueoyesj	1102	2	structural	structural	JJ
cord-000248-zueoyesj	1102	3	component	component	NN
cord-000248-zueoyesj	1102	4	of	of	IN
cord-000248-zueoyesj	1102	5	desmosomes	desmosome	NNS
cord-000248-zueoyesj	1102	6	Decreased	decrease	VBD
cord-000248-zueoyesj	1102	7	plakophilin-1	plakophilin-1	IN
cord-000248-zueoyesj	1102	8	expression	expression	NN
cord-000248-zueoyesj	1102	9	promotes	promote	VBZ
cord-000248-zueoyesj	1102	10	increased	increase	VBN
cord-000248-zueoyesj	1102	11	motility	motility	NN
cord-000248-zueoyesj	1102	12	in	in	IN
cord-000248-zueoyesj	1102	13	head	head	NN
cord-000248-zueoyesj	1102	14	and	and	CC
cord-000248-zueoyesj	1102	15	neck	neck	NN
cord-000248-zueoyesj	1102	16	squamous	squamous	JJ
cord-000248-zueoyesj	1102	17	cell	cell	NN
cord-000248-zueoyesj	1102	18	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1102	19	cells	cell	NNS
cord-000248-zueoyesj	1103	1	The	the	DT
cord-000248-zueoyesj	1103	2	distribution	distribution	NN
cord-000248-zueoyesj	1103	3	of	of	IN
cord-000248-zueoyesj	1103	4	the	the	DT
cord-000248-zueoyesj	1103	5	desmosomal	desmosomal	NNP
cord-000248-zueoyesj	1103	6	protein	protein	NN
cord-000248-zueoyesj	1103	7	,	,	,
cord-000248-zueoyesj	1103	8	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1103	9	1	1	CD
cord-000248-zueoyesj	1103	10	,	,	,
cord-000248-zueoyesj	1103	11	in	in	IN
cord-000248-zueoyesj	1103	12	human	human	JJ
cord-000248-zueoyesj	1103	13	skin	skin	NN
cord-000248-zueoyesj	1103	14	and	and	CC
cord-000248-zueoyesj	1103	15	skin	skin	NN
cord-000248-zueoyesj	1104	1	tumors	tumor	NNS
cord-000248-zueoyesj	1104	2	Plakoglobin	Plakoglobin	NNP
cord-000248-zueoyesj	1104	3	is	be	VBZ
cord-000248-zueoyesj	1104	4	required	require	VBN
cord-000248-zueoyesj	1104	5	for	for	IN
cord-000248-zueoyesj	1104	6	effective	effective	JJ
cord-000248-zueoyesj	1104	7	intermediate	intermediate	JJ
cord-000248-zueoyesj	1104	8	filament	filament	NN
cord-000248-zueoyesj	1104	9	anchorage	anchorage	NNP
cord-000248-zueoyesj	1104	10	to	to	IN
cord-000248-zueoyesj	1104	11	desmosomes	desmosomes	NNP
cord-000248-zueoyesj	1104	12	Plakophilins	Plakophilins	NNP
cord-000248-zueoyesj	1104	13	-	-	HYPH
cord-000248-zueoyesj	1104	14	hard	hard	JJ
cord-000248-zueoyesj	1104	15	work	work	NN
cord-000248-zueoyesj	1104	16	in	in	IN
cord-000248-zueoyesj	1104	17	the	the	DT
cord-000248-zueoyesj	1104	18	desmosome	desmosome	NN
cord-000248-zueoyesj	1104	19	,	,	,
cord-000248-zueoyesj	1104	20	recreation	recreation	NN
cord-000248-zueoyesj	1104	21	in	in	IN
cord-000248-zueoyesj	1104	22	the	the	DT
cord-000248-zueoyesj	1104	23	nucleus	nucleus	NN
cord-000248-zueoyesj	1104	24	?	?	.
cord-000248-zueoyesj	1105	1	The	the	DT
cord-000248-zueoyesj	1105	2	function	function	NN
cord-000248-zueoyesj	1105	3	of	of	IN
cord-000248-zueoyesj	1105	4	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1105	5	1	1	CD
cord-000248-zueoyesj	1105	6	in	in	IN
cord-000248-zueoyesj	1105	7	desmosome	desmosome	NNP
cord-000248-zueoyesj	1105	8	assembly	assembly	NN
cord-000248-zueoyesj	1105	9	and	and	CC
cord-000248-zueoyesj	1105	10	actin	actin	NNP
cord-000248-zueoyesj	1105	11	filament	filament	NN
cord-000248-zueoyesj	1105	12	organization	organization	NN
cord-000248-zueoyesj	1106	1	Plakophilins	plakophilin	NNS
cord-000248-zueoyesj	1106	2	:	:	:
cord-000248-zueoyesj	1107	1	Multifunctional	multifunctional	JJ
cord-000248-zueoyesj	1107	2	proteins	protein	NNS
cord-000248-zueoyesj	1107	3	or	or	CC
cord-000248-zueoyesj	1107	4	just	just	RB
cord-000248-zueoyesj	1107	5	regulators	regulator	NNS
cord-000248-zueoyesj	1107	6	of	of	IN
cord-000248-zueoyesj	1107	7	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	1107	8	adhesion	adhesion	NN
cord-000248-zueoyesj	1107	9	?	?	.
cord-000248-zueoyesj	1108	1	Comparative	comparative	JJ
cord-000248-zueoyesj	1108	2	analysis	analysis	NN
cord-000248-zueoyesj	1108	3	of	of	IN
cord-000248-zueoyesj	1108	4	armadillo	armadillo	NN
cord-000248-zueoyesj	1108	5	family	family	NN
cord-000248-zueoyesj	1108	6	proteins	protein	VBZ
cord-000248-zueoyesj	1108	7	in	in	IN
cord-000248-zueoyesj	1108	8	the	the	DT
cord-000248-zueoyesj	1108	9	regulation	regulation	NN
cord-000248-zueoyesj	1108	10	of	of	IN
cord-000248-zueoyesj	1108	11	a431	a431	NNP
cord-000248-zueoyesj	1108	12	epithelial	epithelial	JJ
cord-000248-zueoyesj	1108	13	cell	cell	NN
cord-000248-zueoyesj	1108	14	junction	junction	NN
cord-000248-zueoyesj	1108	15	assembly	assembly	NN
cord-000248-zueoyesj	1108	16	,	,	,
cord-000248-zueoyesj	1108	17	adhesion	adhesion	NN
cord-000248-zueoyesj	1108	18	and	and	CC
cord-000248-zueoyesj	1108	19	migration	migration	NN
cord-000248-zueoyesj	1108	20	Desmoplakin	Desmoplakin	NNP
cord-000248-zueoyesj	1108	21	assembly	assembly	NN
cord-000248-zueoyesj	1108	22	dynamics	dynamic	NNS
cord-000248-zueoyesj	1108	23	in	in	IN
cord-000248-zueoyesj	1108	24	four	four	CD
cord-000248-zueoyesj	1108	25	dimensions	dimension	NNS
cord-000248-zueoyesj	1108	26	:	:	:
cord-000248-zueoyesj	1109	1	multiple	multiple	JJ
cord-000248-zueoyesj	1109	2	phases	phase	NNS
cord-000248-zueoyesj	1109	3	differentially	differentially	RB
cord-000248-zueoyesj	1109	4	regulated	regulate	VBN
cord-000248-zueoyesj	1109	5	by	by	IN
cord-000248-zueoyesj	1109	6	intermediate	intermediate	JJ
cord-000248-zueoyesj	1109	7	filaments	filament	NNS
cord-000248-zueoyesj	1109	8	and	and	CC
cord-000248-zueoyesj	1109	9	actin	actin	VBG
cord-000248-zueoyesj	1109	10	A	a	DT
cord-000248-zueoyesj	1109	11	role	role	NN
cord-000248-zueoyesj	1109	12	for	for	IN
cord-000248-zueoyesj	1109	13	plakophilin-1	plakophilin-1	NNP
cord-000248-zueoyesj	1109	14	in	in	IN
cord-000248-zueoyesj	1109	15	the	the	DT
cord-000248-zueoyesj	1109	16	initiation	initiation	NN
cord-000248-zueoyesj	1109	17	of	of	IN
cord-000248-zueoyesj	1109	18	desmosome	desmosome	NNP
cord-000248-zueoyesj	1109	19	assembly	assembly	NNP
cord-000248-zueoyesj	1109	20	Lack	Lack	NNP
cord-000248-zueoyesj	1109	21	of	of	IN
cord-000248-zueoyesj	1109	22	plakophilin	plakophilin	NNP
cord-000248-zueoyesj	1109	23	1	1	CD
cord-000248-zueoyesj	1109	24	increases	increase	NNS
cord-000248-zueoyesj	1109	25	keratinocyte	keratinocyte	NNP
cord-000248-zueoyesj	1109	26	migration	migration	NN
cord-000248-zueoyesj	1109	27	and	and	CC
cord-000248-zueoyesj	1109	28	reduces	reduce	VBZ
cord-000248-zueoyesj	1109	29	desmosome	desmosome	NN
cord-000248-zueoyesj	1109	30	stability	stability	NN
cord-000248-zueoyesj	1110	1	The	the	DT
cord-000248-zueoyesj	1110	2	desmoglein	desmoglein	NN
cord-000248-zueoyesj	1110	3	-	-	HYPH
cord-000248-zueoyesj	1110	4	specific	specific	JJ
cord-000248-zueoyesj	1110	5	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	1110	6	region	region	NN
cord-000248-zueoyesj	1110	7	is	be	VBZ
cord-000248-zueoyesj	1110	8	intrinsically	intrinsically	RB
cord-000248-zueoyesj	1110	9	disordered	disordered	JJ
cord-000248-zueoyesj	1110	10	in	in	IN
cord-000248-zueoyesj	1110	11	solution	solution	NN
cord-000248-zueoyesj	1110	12	and	and	CC
cord-000248-zueoyesj	1110	13	interacts	interact	VBZ
cord-000248-zueoyesj	1110	14	with	with	IN
cord-000248-zueoyesj	1110	15	multiple	multiple	JJ
cord-000248-zueoyesj	1110	16	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	1110	17	protein	protein	NN
cord-000248-zueoyesj	1110	18	partners	partner	NNS
cord-000248-zueoyesj	1111	1	The	the	DT
cord-000248-zueoyesj	1111	2	fate	fate	NN
cord-000248-zueoyesj	1111	3	of	of	IN
cord-000248-zueoyesj	1111	4	desmosomal	desmosomal	JJ
cord-000248-zueoyesj	1111	5	proteins	protein	NNS
cord-000248-zueoyesj	1111	6	in	in	IN
cord-000248-zueoyesj	1111	7	apoptotic	apoptotic	JJ
cord-000248-zueoyesj	1111	8	cells	cell	NNS
cord-000248-zueoyesj	1111	9	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	1111	10	water	water	NN
cord-000248-zueoyesj	1111	11	channels	channel	NNS
cord-000248-zueoyesj	1111	12	in	in	IN
cord-000248-zueoyesj	1111	13	mammals	mammal	NNS
cord-000248-zueoyesj	1111	14	Skin	skin	VBP
cord-000248-zueoyesj	1111	15	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1111	16	:	:	:
cord-000248-zueoyesj	1111	17	function	function	VB
cord-000248-zueoyesj	1111	18	in	in	IN
cord-000248-zueoyesj	1111	19	hydration	hydration	NN
cord-000248-zueoyesj	1111	20	,	,	,
cord-000248-zueoyesj	1111	21	wound	wind	VBN
cord-000248-zueoyesj	1111	22	healing	healing	NN
cord-000248-zueoyesj	1111	23	,	,	,
cord-000248-zueoyesj	1111	24	and	and	CC
cord-000248-zueoyesj	1111	25	skin	skin	NN
cord-000248-zueoyesj	1111	26	epidermis	epidermis	NN
cord-000248-zueoyesj	1111	27	homeostasis	homeostasis	NN
cord-000248-zueoyesj	1111	28	Roles	role	NNS
cord-000248-zueoyesj	1111	29	of	of	IN
cord-000248-zueoyesj	1111	30	aquaporin-3	aquaporin-3	NNP
cord-000248-zueoyesj	1111	31	water	water	NN
cord-000248-zueoyesj	1111	32	channels	channel	NNS
cord-000248-zueoyesj	1111	33	in	in	IN
cord-000248-zueoyesj	1111	34	volume	volume	NN
cord-000248-zueoyesj	1111	35	-	-	HYPH
cord-000248-zueoyesj	1111	36	regulatory	regulatory	JJ
cord-000248-zueoyesj	1111	37	water	water	NN
cord-000248-zueoyesj	1111	38	flow	flow	NN
cord-000248-zueoyesj	1111	39	in	in	IN
cord-000248-zueoyesj	1111	40	a	a	DT
cord-000248-zueoyesj	1111	41	human	human	JJ
cord-000248-zueoyesj	1111	42	epithelial	epithelial	JJ
cord-000248-zueoyesj	1111	43	cell	cell	NN
cord-000248-zueoyesj	1111	44	line	line	NN
cord-000248-zueoyesj	1112	1	Osmotic	osmotic	JJ
cord-000248-zueoyesj	1112	2	stress	stress	NN
cord-000248-zueoyesj	1113	1	up	up	RB
cord-000248-zueoyesj	1113	2	-	-	HYPH
cord-000248-zueoyesj	1113	3	regulates	regulate	VBZ
cord-000248-zueoyesj	1113	4	aquaporin-3	aquaporin-3	NN
cord-000248-zueoyesj	1113	5	gene	gene	NN
cord-000248-zueoyesj	1113	6	expression	expression	NN
cord-000248-zueoyesj	1113	7	in	in	IN
cord-000248-zueoyesj	1113	8	cultured	cultured	JJ
cord-000248-zueoyesj	1113	9	human	human	JJ
cord-000248-zueoyesj	1113	10	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	1113	11	Increased	increase	VBN
cord-000248-zueoyesj	1113	12	expression	expression	NN
cord-000248-zueoyesj	1113	13	of	of	IN
cord-000248-zueoyesj	1113	14	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1113	15	3	3	CD
cord-000248-zueoyesj	1113	16	in	in	IN
cord-000248-zueoyesj	1113	17	atopic	atopic	JJ
cord-000248-zueoyesj	1113	18	eczema	eczema	NN
cord-000248-zueoyesj	1113	19	Specific	specific	JJ
cord-000248-zueoyesj	1113	20	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1113	21	facilitate	facilitate	VBP
cord-000248-zueoyesj	1113	22	the	the	DT
cord-000248-zueoyesj	1113	23	diffusion	diffusion	NN
cord-000248-zueoyesj	1113	24	of	of	IN
cord-000248-zueoyesj	1113	25	hydrogen	hydrogen	NN
cord-000248-zueoyesj	1113	26	peroxide	peroxide	NN
cord-000248-zueoyesj	1113	27	across	across	IN
cord-000248-zueoyesj	1113	28	membranes	membrane	NNS
cord-000248-zueoyesj	1114	1	All	all	DT
cord-000248-zueoyesj	1114	2	-	-	HYPH
cord-000248-zueoyesj	1114	3	trans	trans	NNP
cord-000248-zueoyesj	1114	4	retinoic	retinoic	JJ
cord-000248-zueoyesj	1114	5	acid	acid	NN
cord-000248-zueoyesj	1114	6	attenuates	attenuate	VBZ
cord-000248-zueoyesj	1114	7	ultraviolet	ultraviolet	JJ
cord-000248-zueoyesj	1114	8	radiation	radiation	NN
cord-000248-zueoyesj	1114	9	-	-	HYPH
cord-000248-zueoyesj	1114	10	induced	induce	VBN
cord-000248-zueoyesj	1114	11	down	down	NN
cord-000248-zueoyesj	1114	12	-	-	HYPH
cord-000248-zueoyesj	1114	13	regulation	regulation	NN
cord-000248-zueoyesj	1114	14	of	of	IN
cord-000248-zueoyesj	1114	15	aquaporin-3	aquaporin-3	NN
cord-000248-zueoyesj	1114	16	and	and	CC
cord-000248-zueoyesj	1114	17	water	water	NN
cord-000248-zueoyesj	1114	18	permeability	permeability	NN
cord-000248-zueoyesj	1114	19	in	in	IN
cord-000248-zueoyesj	1114	20	human	human	JJ
cord-000248-zueoyesj	1114	21	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	1115	1	Reactive	reactive	JJ
cord-000248-zueoyesj	1115	2	oxygen	oxygen	NN
cord-000248-zueoyesj	1115	3	species	specie	NNS
cord-000248-zueoyesj	1115	4	:	:	:
cord-000248-zueoyesj	1115	5	a	a	DT
cord-000248-zueoyesj	1115	6	breath	breath	NN
cord-000248-zueoyesj	1115	7	of	of	IN
cord-000248-zueoyesj	1115	8	life	life	NN
cord-000248-zueoyesj	1115	9	or	or	CC
cord-000248-zueoyesj	1115	10	death	death	NN
cord-000248-zueoyesj	1115	11	?	?	.
cord-000248-zueoyesj	1116	1	Role	role	NN
cord-000248-zueoyesj	1116	2	of	of	IN
cord-000248-zueoyesj	1116	3	claudins	claudin	NNS
cord-000248-zueoyesj	1116	4	in	in	IN
cord-000248-zueoyesj	1116	5	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1116	6	Changes	change	NNS
cord-000248-zueoyesj	1116	7	in	in	IN
cord-000248-zueoyesj	1116	8	the	the	DT
cord-000248-zueoyesj	1116	9	distribution	distribution	NN
cord-000248-zueoyesj	1116	10	pattern	pattern	NN
cord-000248-zueoyesj	1116	11	of	of	IN
cord-000248-zueoyesj	1116	12	Claudin	Claudin	NNP
cord-000248-zueoyesj	1116	13	tight	tight	JJ
cord-000248-zueoyesj	1116	14	junction	junction	NN
cord-000248-zueoyesj	1116	15	proteins	protein	NNS
cord-000248-zueoyesj	1116	16	during	during	IN
cord-000248-zueoyesj	1116	17	the	the	DT
cord-000248-zueoyesj	1116	18	progression	progression	NN
cord-000248-zueoyesj	1116	19	of	of	IN
cord-000248-zueoyesj	1116	20	mouse	mouse	NN
cord-000248-zueoyesj	1116	21	skin	skin	NN
cord-000248-zueoyesj	1116	22	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1116	23	Claudin-1	Claudin-1	NNP
cord-000248-zueoyesj	1116	24	is	be	VBZ
cord-000248-zueoyesj	1116	25	a	a	DT
cord-000248-zueoyesj	1116	26	metastasis	metastasis	NN
cord-000248-zueoyesj	1116	27	suppressor	suppressor	NN
cord-000248-zueoyesj	1116	28	and	and	CC
cord-000248-zueoyesj	1116	29	correlates	correlate	VBZ
cord-000248-zueoyesj	1116	30	with	with	IN
cord-000248-zueoyesj	1116	31	clinical	clinical	JJ
cord-000248-zueoyesj	1116	32	outcome	outcome	NN
cord-000248-zueoyesj	1116	33	in	in	IN
cord-000248-zueoyesj	1116	34	lung	lung	NN
cord-000248-zueoyesj	1116	35	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1116	36	Reexpression	Reexpression	NNP
cord-000248-zueoyesj	1116	37	of	of	IN
cord-000248-zueoyesj	1116	38	the	the	DT
cord-000248-zueoyesj	1116	39	TJ	TJ	NNP
cord-000248-zueoyesj	1116	40	protein	protein	NN
cord-000248-zueoyesj	1116	41	CLDN1	CLDN1	NNP
cord-000248-zueoyesj	1117	1	induces	induce	VBZ
cord-000248-zueoyesj	1117	2	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1117	3	in	in	IN
cord-000248-zueoyesj	1117	4	breast	breast	NN
cord-000248-zueoyesj	1117	5	tumor	tumor	NN
cord-000248-zueoyesj	1117	6	spheroids	spheroid	NNS
cord-000248-zueoyesj	1117	7	Claudin-1	Claudin-1	NNP
cord-000248-zueoyesj	1117	8	,	,	,
cord-000248-zueoyesj	1117	9	-3	-3	NNP
cord-000248-zueoyesj	1117	10	and	and	CC
cord-000248-zueoyesj	1117	11	-4	-4	NN
cord-000248-zueoyesj	1117	12	proteins	protein	NNS
cord-000248-zueoyesj	1117	13	and	and	CC
cord-000248-zueoyesj	1117	14	mRNA	mrna	NN
cord-000248-zueoyesj	1117	15	expression	expression	NN
cord-000248-zueoyesj	1117	16	in	in	IN
cord-000248-zueoyesj	1117	17	benign	benign	JJ
cord-000248-zueoyesj	1117	18	and	and	CC
cord-000248-zueoyesj	1117	19	malignant	malignant	JJ
cord-000248-zueoyesj	1117	20	breast	breast	NN
cord-000248-zueoyesj	1117	21	lesions	lesion	NNS
cord-000248-zueoyesj	1117	22	:	:	:
cord-000248-zueoyesj	1118	1	a	a	DT
cord-000248-zueoyesj	1118	2	research	research	NN
cord-000248-zueoyesj	1118	3	study	study	NN
cord-000248-zueoyesj	1118	4	Decreased	decrease	VBD
cord-000248-zueoyesj	1118	5	expression	expression	NN
cord-000248-zueoyesj	1118	6	of	of	IN
cord-000248-zueoyesj	1118	7	claudin-1	claudin-1	NNP
cord-000248-zueoyesj	1118	8	correlates	correlate	VBZ
cord-000248-zueoyesj	1118	9	with	with	IN
cord-000248-zueoyesj	1118	10	recurrence	recurrence	NN
cord-000248-zueoyesj	1118	11	status	status	NN
cord-000248-zueoyesj	1118	12	in	in	IN
cord-000248-zueoyesj	1118	13	breast	breast	NN
cord-000248-zueoyesj	1118	14	cancer	cancer	NN
cord-000248-zueoyesj	1118	15	Constitutive	constitutive	JJ
cord-000248-zueoyesj	1118	16	activation	activation	NN
cord-000248-zueoyesj	1118	17	of	of	IN
cord-000248-zueoyesj	1118	18	Wnt	Wnt	NNP
cord-000248-zueoyesj	1118	19	/	/	SYM
cord-000248-zueoyesj	1118	20	beta	beta	NN
cord-000248-zueoyesj	1118	21	-	-	HYPH
cord-000248-zueoyesj	1118	22	catenin	catenin	NN
cord-000248-zueoyesj	1118	23	signaling	signal	VBG
cord-000248-zueoyesj	1118	24	pathway	pathway	NN
cord-000248-zueoyesj	1118	25	in	in	IN
cord-000248-zueoyesj	1118	26	migrationactive	migrationactive	JJ
cord-000248-zueoyesj	1118	27	melanoma	melanoma	NN
cord-000248-zueoyesj	1118	28	cells	cell	NNS
cord-000248-zueoyesj	1118	29	:	:	:
cord-000248-zueoyesj	1119	1	role	role	NN
cord-000248-zueoyesj	1119	2	of	of	IN
cord-000248-zueoyesj	1119	3	LEF-1	LEF-1	NNP
cord-000248-zueoyesj	1119	4	in	in	IN
cord-000248-zueoyesj	1119	5	melanoma	melanoma	NN
cord-000248-zueoyesj	1119	6	with	with	IN
cord-000248-zueoyesj	1119	7	increased	increase	VBN
cord-000248-zueoyesj	1119	8	metastatic	metastatic	JJ
cord-000248-zueoyesj	1119	9	potential	potential	JJ
cord-000248-zueoyesj	1119	10	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1119	11	expression	expression	NN
cord-000248-zueoyesj	1119	12	and	and	CC
cord-000248-zueoyesj	1119	13	distribution	distribution	NN
cord-000248-zueoyesj	1119	14	in	in	IN
cord-000248-zueoyesj	1119	15	human	human	JJ
cord-000248-zueoyesj	1119	16	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1119	17	Functional	functional	JJ
cord-000248-zueoyesj	1119	18	analysis	analysis	NN
cord-000248-zueoyesj	1119	19	of	of	IN
cord-000248-zueoyesj	1119	20	the	the	DT
cord-000248-zueoyesj	1119	21	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1119	22	molecule	molecule	NN
cord-000248-zueoyesj	1119	23	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1119	24	activation	activation	NN
cord-000248-zueoyesj	1119	25	of	of	IN
cord-000248-zueoyesj	1119	26	c	c	NNP
cord-000248-zueoyesj	1119	27	-	-	HYPH
cord-000248-zueoyesj	1119	28	src	src	NNP
cord-000248-zueoyesj	1119	29	in	in	IN
cord-000248-zueoyesj	1119	30	human	human	JJ
cord-000248-zueoyesj	1119	31	melanoma	melanoma	NN
cord-000248-zueoyesj	1119	32	cells	cell	NNS
cord-000248-zueoyesj	1119	33	requires	require	VBZ
cord-000248-zueoyesj	1119	34	the	the	DT
cord-000248-zueoyesj	1119	35	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	1119	36	domain	domain	NN
cord-000248-zueoyesj	1119	37	of	of	IN
cord-000248-zueoyesj	1119	38	the	the	DT
cord-000248-zueoyesj	1119	39	integrin	integrin	NNP
cord-000248-zueoyesj	1119	40	alpha	alpha	NN
cord-000248-zueoyesj	1119	41	v	v	NN
cord-000248-zueoyesj	1119	42	-	-	HYPH
cord-000248-zueoyesj	1119	43	subunit	subunit	NNP
cord-000248-zueoyesj	1119	44	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1119	45	N	n	CD
cord-000248-zueoyesj	1119	46	-	-	HYPH
cord-000248-zueoyesj	1119	47	terminal	terminal	NN
cord-000248-zueoyesj	1119	48	domain	domain	NN
cord-000248-zueoyesj	1119	49	contains	contain	VBZ
cord-000248-zueoyesj	1119	50	a	a	DT
cord-000248-zueoyesj	1119	51	cryptic	cryptic	JJ
cord-000248-zueoyesj	1119	52	adhesive	adhesive	NN
cord-000248-zueoyesj	1119	53	sequence	sequence	NN
cord-000248-zueoyesj	1119	54	recognized	recognize	VBN
cord-000248-zueoyesj	1119	55	by	by	IN
cord-000248-zueoyesj	1119	56	alpha9beta1	alpha9beta1	NNP
cord-000248-zueoyesj	1119	57	integrin	integrin	NN
cord-000248-zueoyesj	1120	1	An	an	DT
cord-000248-zueoyesj	1120	2	examination	examination	NN
cord-000248-zueoyesj	1120	3	of	of	IN
cord-000248-zueoyesj	1120	4	the	the	DT
cord-000248-zueoyesj	1120	5	effects	effect	NNS
cord-000248-zueoyesj	1120	6	of	of	IN
cord-000248-zueoyesj	1120	7	hypoxia	hypoxia	NN
cord-000248-zueoyesj	1120	8	,	,	,
cord-000248-zueoyesj	1120	9	acidosis	acidosis	NN
cord-000248-zueoyesj	1120	10	,	,	,
cord-000248-zueoyesj	1120	11	and	and	CC
cord-000248-zueoyesj	1120	12	glucose	glucose	NN
cord-000248-zueoyesj	1120	13	starvation	starvation	NN
cord-000248-zueoyesj	1120	14	on	on	IN
cord-000248-zueoyesj	1120	15	the	the	DT
cord-000248-zueoyesj	1120	16	expression	expression	NN
cord-000248-zueoyesj	1120	17	of	of	IN
cord-000248-zueoyesj	1120	18	metastasis	metastasis	NN
cord-000248-zueoyesj	1120	19	-	-	HYPH
cord-000248-zueoyesj	1120	20	associated	associate	VBN
cord-000248-zueoyesj	1120	21	genes	gene	NNS
cord-000248-zueoyesj	1120	22	in	in	IN
cord-000248-zueoyesj	1120	23	murine	murine	JJ
cord-000248-zueoyesj	1120	24	tumor	tumor	NN
cord-000248-zueoyesj	1120	25	cells	cell	NNS
cord-000248-zueoyesj	1120	26	Structural	structural	JJ
cord-000248-zueoyesj	1120	27	requirements	requirement	NNS
cord-000248-zueoyesj	1120	28	for	for	IN
cord-000248-zueoyesj	1120	29	alpha	alpha	NN
cord-000248-zueoyesj	1120	30	9	9	CD
cord-000248-zueoyesj	1120	31	beta	beta	NN
cord-000248-zueoyesj	1120	32	1-mediated	1-mediated	CD
cord-000248-zueoyesj	1120	33	adhesion	adhesion	NN
cord-000248-zueoyesj	1120	34	and	and	CC
cord-000248-zueoyesj	1120	35	migration	migration	NN
cord-000248-zueoyesj	1120	36	to	to	IN
cord-000248-zueoyesj	1120	37	thrombin	thrombin	RB
cord-000248-zueoyesj	1120	38	-	-	HYPH
cord-000248-zueoyesj	1120	39	cleaved	cleave	VBN
cord-000248-zueoyesj	1120	40	osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1120	41	Chimeric	chimeric	JJ
cord-000248-zueoyesj	1120	42	peptides	peptide	NNS
cord-000248-zueoyesj	1120	43	of	of	IN
cord-000248-zueoyesj	1120	44	statherin	statherin	NNP
cord-000248-zueoyesj	1120	45	and	and	CC
cord-000248-zueoyesj	1120	46	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1120	47	that	that	WDT
cord-000248-zueoyesj	1120	48	bind	bind	VBP
cord-000248-zueoyesj	1120	49	hydroxyapatite	hydroxyapatite	NN
cord-000248-zueoyesj	1120	50	and	and	CC
cord-000248-zueoyesj	1120	51	mediate	mediate	VB
cord-000248-zueoyesj	1120	52	cell	cell	NN
cord-000248-zueoyesj	1120	53	adhesion	adhesion	NN
cord-000248-zueoyesj	1120	54	Natural	natural	JJ
cord-000248-zueoyesj	1120	55	metabolites	metabolite	NNS
cord-000248-zueoyesj	1120	56	of	of	IN
cord-000248-zueoyesj	1120	57	1alpha	1alpha	CD
cord-000248-zueoyesj	1120	58	,	,	,
cord-000248-zueoyesj	1120	59	25-dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-000248-zueoyesj	1120	60	D(3	D(3	NNS
cord-000248-zueoyesj	1120	61	)	)	-RRB-
cord-000248-zueoyesj	1120	62	retain	retain	VB
cord-000248-zueoyesj	1120	63	biologic	biologic	JJ
cord-000248-zueoyesj	1120	64	activity	activity	NN
cord-000248-zueoyesj	1120	65	mediated	mediate	VBN
cord-000248-zueoyesj	1120	66	through	through	IN
cord-000248-zueoyesj	1120	67	the	the	DT
cord-000248-zueoyesj	1120	68	vitamin	vitamin	NN
cord-000248-zueoyesj	1120	69	D	D	NNP
cord-000248-zueoyesj	1120	70	receptor	receptor	NN
cord-000248-zueoyesj	1120	71	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1120	72	deficiency	deficiency	NN
cord-000248-zueoyesj	1120	73	reduces	reduce	VBZ
cord-000248-zueoyesj	1120	74	experimental	experimental	JJ
cord-000248-zueoyesj	1120	75	tumor	tumor	NN
cord-000248-zueoyesj	1120	76	cell	cell	NN
cord-000248-zueoyesj	1120	77	metastasis	metastasis	NN
cord-000248-zueoyesj	1120	78	to	to	IN
cord-000248-zueoyesj	1120	79	bone	bone	NN
cord-000248-zueoyesj	1120	80	and	and	CC
cord-000248-zueoyesj	1120	81	soft	soft	JJ
cord-000248-zueoyesj	1120	82	tissues	tissue	NNS
cord-000248-zueoyesj	1120	83	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1120	84	stimulates	stimulate	VBZ
cord-000248-zueoyesj	1120	85	tumor	tumor	NN
cord-000248-zueoyesj	1120	86	growth	growth	NN
cord-000248-zueoyesj	1120	87	and	and	CC
cord-000248-zueoyesj	1120	88	activation	activation	NN
cord-000248-zueoyesj	1120	89	of	of	IN
cord-000248-zueoyesj	1120	90	promatrix	promatrix	NNP
cord-000248-zueoyesj	1120	91	metalloproteinase-2	metalloproteinase-2	NNP
cord-000248-zueoyesj	1120	92	through	through	IN
cord-000248-zueoyesj	1120	93	nuclear	nuclear	JJ
cord-000248-zueoyesj	1120	94	factor	factor	NN
cord-000248-zueoyesj	1120	95	-	-	HYPH
cord-000248-zueoyesj	1120	96	kappa	kappa	NN
cord-000248-zueoyesj	1120	97	B	b	NN
cord-000248-zueoyesj	1120	98	-	-	HYPH
cord-000248-zueoyesj	1120	99	mediated	mediate	VBN
cord-000248-zueoyesj	1120	100	induction	induction	NN
cord-000248-zueoyesj	1120	101	of	of	IN
cord-000248-zueoyesj	1120	102	membrane	membrane	NN
cord-000248-zueoyesj	1120	103	type	type	NN
cord-000248-zueoyesj	1120	104	1	1	CD
cord-000248-zueoyesj	1120	105	matrix	matrix	NN
cord-000248-zueoyesj	1120	106	metalloproteinase	metalloproteinase	NN
cord-000248-zueoyesj	1120	107	in	in	IN
cord-000248-zueoyesj	1120	108	murine	murine	JJ
cord-000248-zueoyesj	1120	109	melanoma	melanoma	NN
cord-000248-zueoyesj	1120	110	cells	cell	NNS
cord-000248-zueoyesj	1121	1	Autocrine	Autocrine	NNP
cord-000248-zueoyesj	1121	2	stimulation	stimulation	NN
cord-000248-zueoyesj	1121	3	by	by	IN
cord-000248-zueoyesj	1121	4	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1121	5	contributes	contribute	VBZ
cord-000248-zueoyesj	1121	6	to	to	IN
cord-000248-zueoyesj	1121	7	antiapoptotic	antiapoptotic	JJ
cord-000248-zueoyesj	1121	8	signalling	signalling	NN
cord-000248-zueoyesj	1121	9	of	of	IN
cord-000248-zueoyesj	1121	10	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1121	11	in	in	IN
cord-000248-zueoyesj	1121	12	dermal	dermal	JJ
cord-000248-zueoyesj	1121	13	collagen	collagen	NN
cord-000248-zueoyesj	1121	14	Cooperative	cooperative	JJ
cord-000248-zueoyesj	1121	15	role	role	NN
cord-000248-zueoyesj	1121	16	of	of	IN
cord-000248-zueoyesj	1121	17	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1121	18	with	with	IN
cord-000248-zueoyesj	1121	19	type	type	NN
cord-000248-zueoyesj	1121	20	I	-PRON-	PRP
cord-000248-zueoyesj	1121	21	collagen	collagen	NN
cord-000248-zueoyesj	1121	22	on	on	IN
cord-000248-zueoyesj	1121	23	the	the	DT
cord-000248-zueoyesj	1121	24	metastasis	metastasis	NN
cord-000248-zueoyesj	1121	25	of	of	IN
cord-000248-zueoyesj	1121	26	murine	murine	JJ
cord-000248-zueoyesj	1121	27	melanoma	melanoma	NN
cord-000248-zueoyesj	1121	28	cells	cell	NNS
cord-000248-zueoyesj	1122	1	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1122	2	induces	induce	VBZ
cord-000248-zueoyesj	1122	3	nuclear	nuclear	JJ
cord-000248-zueoyesj	1122	4	factor	factor	NN
cord-000248-zueoyesj	1122	5	kappa	kappa	NN
cord-000248-zueoyesj	1122	6	Bmediated	Bmediated	NNP
cord-000248-zueoyesj	1122	7	promatrix	promatrix	NN
cord-000248-zueoyesj	1122	8	metalloproteinase-2	metalloproteinase-2	NNP
cord-000248-zueoyesj	1122	9	activation	activation	NN
cord-000248-zueoyesj	1122	10	through	through	IN
cord-000248-zueoyesj	1122	11	I	I	NNP
cord-000248-zueoyesj	1122	12	kappa	kappa	NN
cord-000248-zueoyesj	1122	13	B	B	NNP
cord-000248-zueoyesj	1123	1	alpha/	alpha/	NN
cord-000248-zueoyesj	1123	2	IKK	IKK	NNP
cord-000248-zueoyesj	1123	3	signaling	signal	VBG
cord-000248-zueoyesj	1123	4	pathways	pathway	NNS
cord-000248-zueoyesj	1123	5	,	,	,
cord-000248-zueoyesj	1123	6	and	and	CC
cord-000248-zueoyesj	1123	7	curcumin	curcumin	NN
cord-000248-zueoyesj	1123	8	(	(	-LRB-
cord-000248-zueoyesj	1123	9	diferulolylmethane	diferulolylmethane	NNP
cord-000248-zueoyesj	1123	10	)	)	-RRB-
cord-000248-zueoyesj	1123	11	down	down	RB
cord-000248-zueoyesj	1123	12	-	-	,
cord-000248-zueoyesj	1123	13	regulates	regulate	VBZ
cord-000248-zueoyesj	1123	14	these	these	DT
cord-000248-zueoyesj	1123	15	pathways	pathway	NNS
cord-000248-zueoyesj	1124	1	Osteopontin	osteopontin	NN
cord-000248-zueoyesj	1124	2	-	-	HYPH
cord-000248-zueoyesj	1124	3	deficiency	deficiency	NN
cord-000248-zueoyesj	1124	4	suppresses	suppress	VBZ
cord-000248-zueoyesj	1124	5	growth	growth	NN
cord-000248-zueoyesj	1124	6	of	of	IN
cord-000248-zueoyesj	1124	7	B16	B16	NNP
cord-000248-zueoyesj	1124	8	melanoma	melanoma	NN
cord-000248-zueoyesj	1124	9	cells	cell	NNS
cord-000248-zueoyesj	1124	10	implanted	implant	VBN
cord-000248-zueoyesj	1124	11	in	in	IN
cord-000248-zueoyesj	1124	12	bone	bone	NN
cord-000248-zueoyesj	1124	13	and	and	CC
cord-000248-zueoyesj	1124	14	osteoclastogenesis	osteoclastogenesis	NN
cord-000248-zueoyesj	1124	15	in	in	IN
cord-000248-zueoyesj	1124	16	co	co	NNS
cord-000248-zueoyesj	1124	17	-	-	NNS
cord-000248-zueoyesj	1124	18	cultures	culture	NNS
cord-000248-zueoyesj	1124	19	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1124	20	factor	factor	NN
cord-000248-zueoyesj	1124	21	-	-	HYPH
cord-000248-zueoyesj	1124	22	inducing	induce	VBG
cord-000248-zueoyesj	1124	23	kinase	kinase	NN
cord-000248-zueoyesj	1124	24	plays	play	VBZ
cord-000248-zueoyesj	1124	25	a	a	DT
cord-000248-zueoyesj	1124	26	crucial	crucial	JJ
cord-000248-zueoyesj	1124	27	role	role	NN
cord-000248-zueoyesj	1124	28	in	in	IN
cord-000248-zueoyesj	1124	29	osteopontin	osteopontin	NN
cord-000248-zueoyesj	1124	30	-	-	HYPH
cord-000248-zueoyesj	1124	31	induced	induce	VBN
cord-000248-zueoyesj	1124	32	MAPK	MAPK	NNP
cord-000248-zueoyesj	1124	33	/	/	SYM
cord-000248-zueoyesj	1124	34	IkappaBalpha	IkappaBalpha	NNP
cord-000248-zueoyesj	1124	35	kinasedependent	kinasedependent	NN
cord-000248-zueoyesj	1124	36	nuclear	nuclear	JJ
cord-000248-zueoyesj	1124	37	factor	factor	NN
cord-000248-zueoyesj	1124	38	kappaB	kappaB	NNP
cord-000248-zueoyesj	1124	39	-	-	HYPH
cord-000248-zueoyesj	1124	40	mediated	mediate	VBN
cord-000248-zueoyesj	1124	41	promatrix	promatrix	NNP
cord-000248-zueoyesj	1124	42	metalloproteinase-9	metalloproteinase-9	NNP
cord-000248-zueoyesj	1124	43	activation	activation	NN
cord-000248-zueoyesj	1124	44	Gene	Gene	NNP
cord-000248-zueoyesj	1124	45	expression	expression	NN
cord-000248-zueoyesj	1124	46	analysis	analysis	NN
cord-000248-zueoyesj	1124	47	to	to	TO
cord-000248-zueoyesj	1124	48	identify	identify	VB
cord-000248-zueoyesj	1124	49	mRNA	mrna	NN
cord-000248-zueoyesj	1124	50	markers	marker	NNS
cord-000248-zueoyesj	1124	51	of	of	IN
cord-000248-zueoyesj	1124	52	cardiac	cardiac	JJ
cord-000248-zueoyesj	1124	53	myxoma	myxoma	NNP
cord-000248-zueoyesj	1124	54	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1125	1	:	:	:
cord-000248-zueoyesj	1125	2	it	-PRON-	PRP
cord-000248-zueoyesj	1125	3	's	be	VBZ
cord-000248-zueoyesj	1125	4	role	role	NN
cord-000248-zueoyesj	1125	5	in	in	IN
cord-000248-zueoyesj	1125	6	regulation	regulation	NN
cord-000248-zueoyesj	1125	7	of	of	IN
cord-000248-zueoyesj	1125	8	cell	cell	NN
cord-000248-zueoyesj	1125	9	motility	motility	NN
cord-000248-zueoyesj	1125	10	and	and	CC
cord-000248-zueoyesj	1125	11	nuclear	nuclear	JJ
cord-000248-zueoyesj	1125	12	factor	factor	NN
cord-000248-zueoyesj	1125	13	kappa	kappa	NN
cord-000248-zueoyesj	1125	14	B	B	NNP
cord-000248-zueoyesj	1125	15	-	-	HYPH
cord-000248-zueoyesj	1125	16	mediated	mediate	VBN
cord-000248-zueoyesj	1125	17	urokinase	urokinase	NN
cord-000248-zueoyesj	1125	18	type	type	NN
cord-000248-zueoyesj	1125	19	plasminogen	plasminogen	NN
cord-000248-zueoyesj	1125	20	activator	activator	NN
cord-000248-zueoyesj	1125	21	expression	expression	NN
cord-000248-zueoyesj	1126	1	Osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1126	2	expression	expression	NN
cord-000248-zueoyesj	1126	3	correlates	correlate	VBZ
cord-000248-zueoyesj	1126	4	with	with	IN
cord-000248-zueoyesj	1126	5	melanoma	melanoma	NN
cord-000248-zueoyesj	1126	6	invasion	invasion	NN
cord-000248-zueoyesj	1126	7	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1126	8	in	in	IN
cord-000248-zueoyesj	1126	9	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	1126	10	lesions	lesion	NNS
cord-000248-zueoyesj	1126	11	-	-	:
cord-000248-zueoyesj	1126	12	a	a	DT
cord-000248-zueoyesj	1126	13	first	first	JJ
cord-000248-zueoyesj	1126	14	step	step	NN
cord-000248-zueoyesj	1126	15	towards	towards	IN
cord-000248-zueoyesj	1126	16	invasion	invasion	NN
cord-000248-zueoyesj	1126	17	?	?	.
cord-000248-zueoyesj	1127	1	Osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1127	2	expression	expression	NN
cord-000248-zueoyesj	1127	3	correlates	correlate	VBZ
cord-000248-zueoyesj	1127	4	with	with	IN
cord-000248-zueoyesj	1127	5	melanoma	melanoma	NN
cord-000248-zueoyesj	1127	6	invasion	invasion	NN
cord-000248-zueoyesj	1127	7	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1127	8	expression	expression	NN
cord-000248-zueoyesj	1127	9	and	and	CC
cord-000248-zueoyesj	1127	10	serum	serum	NN
cord-000248-zueoyesj	1127	11	levels	level	NNS
cord-000248-zueoyesj	1127	12	in	in	IN
cord-000248-zueoyesj	1127	13	metastatic	metastatic	JJ
cord-000248-zueoyesj	1127	14	uveal	uveal	JJ
cord-000248-zueoyesj	1127	15	melanoma	melanoma	NN
cord-000248-zueoyesj	1127	16	:	:	:
cord-000248-zueoyesj	1127	17	a	a	DT
cord-000248-zueoyesj	1127	18	pilot	pilot	NN
cord-000248-zueoyesj	1127	19	study	study	NN
cord-000248-zueoyesj	1127	20	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1127	21	is	be	VBZ
cord-000248-zueoyesj	1127	22	a	a	DT
cord-000248-zueoyesj	1127	23	downstream	downstream	JJ
cord-000248-zueoyesj	1127	24	effector	effector	NN
cord-000248-zueoyesj	1127	25	of	of	IN
cord-000248-zueoyesj	1127	26	the	the	DT
cord-000248-zueoyesj	1127	27	PI3-kinase	pi3-kinase	NN
cord-000248-zueoyesj	1127	28	pathway	pathway	NN
cord-000248-zueoyesj	1127	29	in	in	IN
cord-000248-zueoyesj	1127	30	melanomas	melanoma	NNS
cord-000248-zueoyesj	1128	1	that	that	DT
cord-000248-zueoyesj	1128	2	is	be	VBZ
cord-000248-zueoyesj	1128	3	inversely	inversely	RB
cord-000248-zueoyesj	1128	4	correlated	correlate	VBN
cord-000248-zueoyesj	1128	5	with	with	IN
cord-000248-zueoyesj	1128	6	functional	functional	JJ
cord-000248-zueoyesj	1128	7	PTEN	PTEN	NNP
cord-000248-zueoyesj	1128	8	Alpha	Alpha	NNP
cord-000248-zueoyesj	1128	9	-	-	HYPH
cord-000248-zueoyesj	1128	10	V	v	NN
cord-000248-zueoyesj	1128	11	-	-	HYPH
cord-000248-zueoyesj	1128	12	dependent	dependent	JJ
cord-000248-zueoyesj	1128	13	outside	outside	IN
cord-000248-zueoyesj	1128	14	-	-	HYPH
cord-000248-zueoyesj	1128	15	in	in	NN
cord-000248-zueoyesj	1128	16	signaling	signaling	NN
cord-000248-zueoyesj	1128	17	is	be	VBZ
cord-000248-zueoyesj	1128	18	required	require	VBN
cord-000248-zueoyesj	1128	19	for	for	IN
cord-000248-zueoyesj	1128	20	the	the	DT
cord-000248-zueoyesj	1128	21	regulation	regulation	NN
cord-000248-zueoyesj	1128	22	of	of	IN
cord-000248-zueoyesj	1128	23	CD44	CD44	NNP
cord-000248-zueoyesj	1128	24	surface	surface	NN
cord-000248-zueoyesj	1128	25	expression	expression	NN
cord-000248-zueoyesj	1128	26	,	,	,
cord-000248-zueoyesj	1128	27	MMP-2	MMP-2	NNP
cord-000248-zueoyesj	1128	28	secretion	secretion	NN
cord-000248-zueoyesj	1128	29	,	,	,
cord-000248-zueoyesj	1128	30	and	and	CC
cord-000248-zueoyesj	1128	31	cell	cell	NN
cord-000248-zueoyesj	1128	32	migration	migration	NN
cord-000248-zueoyesj	1128	33	by	by	IN
cord-000248-zueoyesj	1128	34	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1128	35	in	in	IN
cord-000248-zueoyesj	1128	36	human	human	JJ
cord-000248-zueoyesj	1128	37	melanoma	melanoma	NN
cord-000248-zueoyesj	1128	38	cells	cell	NNS
cord-000248-zueoyesj	1128	39	Regulation	regulation	NN
cord-000248-zueoyesj	1128	40	of	of	IN
cord-000248-zueoyesj	1128	41	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	1128	42	stem	stem	NN
cord-000248-zueoyesj	1128	43	cell	cell	NN
cord-000248-zueoyesj	1128	44	and	and	CC
cord-000248-zueoyesj	1128	45	chondrocyte	chondrocyte	NN
cord-000248-zueoyesj	1128	46	differentiation	differentiation	NN
cord-000248-zueoyesj	1128	47	by	by	IN
cord-000248-zueoyesj	1128	48	MIA	MIA	NNP
cord-000248-zueoyesj	1128	49	Systematic	systematic	JJ
cord-000248-zueoyesj	1128	50	search	search	NN
cord-000248-zueoyesj	1128	51	for	for	IN
cord-000248-zueoyesj	1128	52	the	the	DT
cord-000248-zueoyesj	1128	53	best	good	JJS
cord-000248-zueoyesj	1128	54	gene	gene	NN
cord-000248-zueoyesj	1128	55	expression	expression	NN
cord-000248-zueoyesj	1128	56	markers	marker	NNS
cord-000248-zueoyesj	1128	57	for	for	IN
cord-000248-zueoyesj	1128	58	melanoma	melanoma	NN
cord-000248-zueoyesj	1128	59	micrometastasis	micrometastasis	NN
cord-000248-zueoyesj	1128	60	detection	detection	NN
cord-000248-zueoyesj	1128	61	CD44	CD44	NNP
cord-000248-zueoyesj	1128	62	and	and	CC
cord-000248-zueoyesj	1128	63	the	the	DT
cord-000248-zueoyesj	1128	64	adhesion	adhesion	NN
cord-000248-zueoyesj	1128	65	of	of	IN
cord-000248-zueoyesj	1128	66	neoplastic	neoplastic	JJ
cord-000248-zueoyesj	1128	67	cells	cell	NNS
cord-000248-zueoyesj	1128	68	Non	Non	NNP
cord-000248-zueoyesj	1128	69	-	-	JJ
cord-000248-zueoyesj	1128	70	RGD	RGD	NNP
cord-000248-zueoyesj	1128	71	domains	domain	NNS
cord-000248-zueoyesj	1128	72	of	of	IN
cord-000248-zueoyesj	1128	73	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1128	74	promote	promote	VBP
cord-000248-zueoyesj	1128	75	cell	cell	NN
cord-000248-zueoyesj	1128	76	adhesion	adhesion	NN
cord-000248-zueoyesj	1128	77	without	without	IN
cord-000248-zueoyesj	1128	78	involving	involve	VBG
cord-000248-zueoyesj	1128	79	alpha	alpha	NN
cord-000248-zueoyesj	1128	80	v	v	NN
cord-000248-zueoyesj	1129	1	integrins	integrins	NNP
cord-000248-zueoyesj	1129	2	Secreted	secrete	VBD
cord-000248-zueoyesj	1129	3	phosphoprotein	phosphoprotein	NN
cord-000248-zueoyesj	1129	4	mRNA	mrna	NN
cord-000248-zueoyesj	1129	5	is	be	VBZ
cord-000248-zueoyesj	1129	6	induced	induce	VBN
cord-000248-zueoyesj	1129	7	during	during	IN
cord-000248-zueoyesj	1129	8	multi	multi	JJ
cord-000248-zueoyesj	1129	9	-	-	JJ
cord-000248-zueoyesj	1129	10	stage	stage	JJ
cord-000248-zueoyesj	1129	11	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1129	12	in	in	IN
cord-000248-zueoyesj	1129	13	mouse	mouse	NN
cord-000248-zueoyesj	1129	14	skin	skin	NN
cord-000248-zueoyesj	1129	15	and	and	CC
cord-000248-zueoyesj	1129	16	correlates	correlate	VBZ
cord-000248-zueoyesj	1129	17	with	with	IN
cord-000248-zueoyesj	1129	18	the	the	DT
cord-000248-zueoyesj	1129	19	metastatic	metastatic	JJ
cord-000248-zueoyesj	1129	20	potential	potential	NN
cord-000248-zueoyesj	1129	21	of	of	IN
cord-000248-zueoyesj	1129	22	murine	murine	JJ
cord-000248-zueoyesj	1129	23	fibroblasts	fibroblast	NNS
cord-000248-zueoyesj	1129	24	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1129	25	as	as	IN
cord-000248-zueoyesj	1129	26	a	a	DT
cord-000248-zueoyesj	1129	27	molecular	molecular	JJ
cord-000248-zueoyesj	1129	28	prognostic	prognostic	JJ
cord-000248-zueoyesj	1129	29	marker	marker	NN
cord-000248-zueoyesj	1129	30	for	for	IN
cord-000248-zueoyesj	1129	31	melanoma	melanoma	NN
cord-000248-zueoyesj	1129	32	Aurora	Aurora	NNP
cord-000248-zueoyesj	1129	33	B	B	NNP
cord-000248-zueoyesj	1129	34	-	-	HYPH
cord-000248-zueoyesj	1129	35	mediated	mediate	VBN
cord-000248-zueoyesj	1129	36	abscission	abscission	NN
cord-000248-zueoyesj	1129	37	checkpoint	checkpoint	NN
cord-000248-zueoyesj	1129	38	protects	protect	VBZ
cord-000248-zueoyesj	1129	39	against	against	IN
cord-000248-zueoyesj	1129	40	tetraploidization	tetraploidization	NNP
cord-000248-zueoyesj	1129	41	SNS-314	SNS-314	NNP
cord-000248-zueoyesj	1129	42	,	,	,
cord-000248-zueoyesj	1129	43	a	a	DT
cord-000248-zueoyesj	1129	44	pan	pan	JJ
cord-000248-zueoyesj	1129	45	-	-	JJ
cord-000248-zueoyesj	1129	46	Aurora	Aurora	NNP
cord-000248-zueoyesj	1129	47	kinase	kinase	NN
cord-000248-zueoyesj	1129	48	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1129	49	,	,	,
cord-000248-zueoyesj	1129	50	shows	show	VBZ
cord-000248-zueoyesj	1129	51	potent	potent	JJ
cord-000248-zueoyesj	1129	52	anti	anti	JJ
cord-000248-zueoyesj	1129	53	-	-	JJ
cord-000248-zueoyesj	1129	54	tumor	tumor	JJ
cord-000248-zueoyesj	1129	55	activity	activity	NN
cord-000248-zueoyesj	1129	56	and	and	CC
cord-000248-zueoyesj	1129	57	dosing	dose	VBG
cord-000248-zueoyesj	1129	58	flexibility	flexibility	NN
cord-000248-zueoyesj	1129	59	in	in	IN
cord-000248-zueoyesj	1129	60	vivo	vivo	NNP
cord-000248-zueoyesj	1129	61	MAP	MAP	NNP
cord-000248-zueoyesj	1129	62	kinase	kinase	NN
cord-000248-zueoyesj	1129	63	meets	meet	VBZ
cord-000248-zueoyesj	1129	64	mitosis	mitosis	NN
cord-000248-zueoyesj	1129	65	:	:	:
cord-000248-zueoyesj	1130	1	a	a	DT
cord-000248-zueoyesj	1130	2	role	role	NN
cord-000248-zueoyesj	1130	3	for	for	IN
cord-000248-zueoyesj	1130	4	Raf	Raf	NNP
cord-000248-zueoyesj	1130	5	Kinase	Kinase	NNP
cord-000248-zueoyesj	1130	6	Inhibitory	Inhibitory	NNP
cord-000248-zueoyesj	1130	7	Protein	Protein	NNP
cord-000248-zueoyesj	1130	8	in	in	IN
cord-000248-zueoyesj	1130	9	spindle	spindle	NN
cord-000248-zueoyesj	1130	10	checkpoint	checkpoint	NN
cord-000248-zueoyesj	1130	11	regulation	regulation	NN
cord-000248-zueoyesj	1130	12	Molecular	molecular	JJ
cord-000248-zueoyesj	1130	13	classification	classification	NN
cord-000248-zueoyesj	1130	14	of	of	IN
cord-000248-zueoyesj	1130	15	melanoma	melanoma	NN
cord-000248-zueoyesj	1130	16	using	use	VBG
cord-000248-zueoyesj	1130	17	real	real	JJ
cord-000248-zueoyesj	1130	18	-	-	HYPH
cord-000248-zueoyesj	1130	19	time	time	NN
cord-000248-zueoyesj	1130	20	quantitative	quantitative	JJ
cord-000248-zueoyesj	1130	21	reverse	reverse	NN
cord-000248-zueoyesj	1130	22	transcriptasepolymerase	transcriptasepolymerase	NN
cord-000248-zueoyesj	1130	23	chain	chain	NN
cord-000248-zueoyesj	1130	24	reaction	reaction	NN
cord-000248-zueoyesj	1130	25	The	the	DT
cord-000248-zueoyesj	1130	26	gene	gene	NN
cord-000248-zueoyesj	1130	27	expression	expression	NN
cord-000248-zueoyesj	1130	28	profiles	profile	NNS
cord-000248-zueoyesj	1130	29	of	of	IN
cord-000248-zueoyesj	1130	30	primary	primary	JJ
cord-000248-zueoyesj	1130	31	and	and	CC
cord-000248-zueoyesj	1130	32	metastatic	metastatic	JJ
cord-000248-zueoyesj	1130	33	melanoma	melanoma	NN
cord-000248-zueoyesj	1130	34	yields	yield	VBZ
cord-000248-zueoyesj	1130	35	a	a	DT
cord-000248-zueoyesj	1130	36	transition	transition	NN
cord-000248-zueoyesj	1130	37	point	point	NN
cord-000248-zueoyesj	1130	38	of	of	IN
cord-000248-zueoyesj	1130	39	tumor	tumor	NN
cord-000248-zueoyesj	1130	40	progression	progression	NN
cord-000248-zueoyesj	1130	41	and	and	CC
cord-000248-zueoyesj	1130	42	metastasis	metastasis	NN
cord-000248-zueoyesj	1130	43	Defective	defective	JJ
cord-000248-zueoyesj	1130	44	cell	cell	NN
cord-000248-zueoyesj	1130	45	cycle	cycle	NN
cord-000248-zueoyesj	1130	46	checkpoint	checkpoint	NN
cord-000248-zueoyesj	1130	47	functions	function	NNS
cord-000248-zueoyesj	1130	48	in	in	IN
cord-000248-zueoyesj	1130	49	melanoma	melanoma	NN
cord-000248-zueoyesj	1130	50	are	be	VBP
cord-000248-zueoyesj	1130	51	associated	associate	VBN
cord-000248-zueoyesj	1130	52	with	with	IN
cord-000248-zueoyesj	1130	53	altered	altered	JJ
cord-000248-zueoyesj	1130	54	patterns	pattern	NNS
cord-000248-zueoyesj	1130	55	of	of	IN
cord-000248-zueoyesj	1130	56	gene	gene	NN
cord-000248-zueoyesj	1130	57	expression	expression	NN
cord-000248-zueoyesj	1130	58	Cdc7	cdc7	CD
cord-000248-zueoyesj	1130	59	expression	expression	NN
cord-000248-zueoyesj	1130	60	in	in	IN
cord-000248-zueoyesj	1130	61	melanomas	melanoma	NNS
cord-000248-zueoyesj	1130	62	,	,	,
cord-000248-zueoyesj	1131	1	Spitz	spitz	JJ
cord-000248-zueoyesj	1131	2	tumors	tumor	NNS
cord-000248-zueoyesj	1131	3	and	and	CC
cord-000248-zueoyesj	1131	4	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	1131	5	nevi	nevus	NNS
cord-000248-zueoyesj	1131	6	Global	global	JJ
cord-000248-zueoyesj	1131	7	analysis	analysis	NN
cord-000248-zueoyesj	1131	8	of	of	IN
cord-000248-zueoyesj	1131	9	gene	gene	NN
cord-000248-zueoyesj	1131	10	expression	expression	NN
cord-000248-zueoyesj	1131	11	changes	change	NNS
cord-000248-zueoyesj	1131	12	during	during	IN
cord-000248-zueoyesj	1131	13	retinoic	retinoic	JJ
cord-000248-zueoyesj	1131	14	acid	acid	NN
cord-000248-zueoyesj	1131	15	-	-	HYPH
cord-000248-zueoyesj	1131	16	induced	induce	VBN
cord-000248-zueoyesj	1131	17	growth	growth	NN
cord-000248-zueoyesj	1131	18	arrest	arrest	NN
cord-000248-zueoyesj	1131	19	and	and	CC
cord-000248-zueoyesj	1131	20	differentiation	differentiation	NN
cord-000248-zueoyesj	1131	21	of	of	IN
cord-000248-zueoyesj	1131	22	melanoma	melanoma	NN
cord-000248-zueoyesj	1131	23	:	:	:
cord-000248-zueoyesj	1131	24	comparison	comparison	NN
cord-000248-zueoyesj	1131	25	to	to	TO
cord-000248-zueoyesj	1131	26	differentially	differentially	RB
cord-000248-zueoyesj	1131	27	expressed	express	VBN
cord-000248-zueoyesj	1131	28	genes	gene	NNS
cord-000248-zueoyesj	1131	29	in	in	IN
cord-000248-zueoyesj	1131	30	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1131	31	vs	vs	IN
cord-000248-zueoyesj	1131	32	melanoma	melanoma	NN
cord-000248-zueoyesj	1131	33	Cell	cell	NN
cord-000248-zueoyesj	1131	34	cycle	cycle	NN
cord-000248-zueoyesj	1131	35	regulation	regulation	NN
cord-000248-zueoyesj	1131	36	of	of	IN
cord-000248-zueoyesj	1131	37	central	central	JJ
cord-000248-zueoyesj	1131	38	spindle	spindle	NN
cord-000248-zueoyesj	1131	39	assembly	assembly	NN
cord-000248-zueoyesj	1131	40	Relocation	Relocation	NNP
cord-000248-zueoyesj	1131	41	of	of	IN
cord-000248-zueoyesj	1131	42	Aurora	Aurora	NNP
cord-000248-zueoyesj	1131	43	B	B	NNP
cord-000248-zueoyesj	1131	44	from	from	IN
cord-000248-zueoyesj	1131	45	centromeres	centromere	NNS
cord-000248-zueoyesj	1131	46	to	to	IN
cord-000248-zueoyesj	1131	47	the	the	DT
cord-000248-zueoyesj	1131	48	central	central	JJ
cord-000248-zueoyesj	1131	49	spindle	spindle	NN
cord-000248-zueoyesj	1131	50	at	at	IN
cord-000248-zueoyesj	1131	51	the	the	DT
cord-000248-zueoyesj	1131	52	metaphase	metaphase	NN
cord-000248-zueoyesj	1131	53	to	to	TO
cord-000248-zueoyesj	1131	54	anaphase	anaphase	VB
cord-000248-zueoyesj	1131	55	transition	transition	NN
cord-000248-zueoyesj	1131	56	requires	require	VBZ
cord-000248-zueoyesj	1131	57	MKlp2	MKlp2	NNP
cord-000248-zueoyesj	1131	58	ASAP	ASAP	NNP
cord-000248-zueoyesj	1131	59	is	be	VBZ
cord-000248-zueoyesj	1131	60	a	a	DT
cord-000248-zueoyesj	1131	61	novel	novel	JJ
cord-000248-zueoyesj	1131	62	substrate	substrate	NN
cord-000248-zueoyesj	1131	63	of	of	IN
cord-000248-zueoyesj	1131	64	the	the	DT
cord-000248-zueoyesj	1131	65	oncogenic	oncogenic	JJ
cord-000248-zueoyesj	1131	66	mitotic	mitotic	JJ
cord-000248-zueoyesj	1131	67	kinase	kinase	NN
cord-000248-zueoyesj	1131	68	Aurora	Aurora	NNP
cord-000248-zueoyesj	1131	69	-	-	HYPH
cord-000248-zueoyesj	1131	70	A	A	NNP
cord-000248-zueoyesj	1131	71	:	:	:
cord-000248-zueoyesj	1131	72	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	1131	73	on	on	IN
cord-000248-zueoyesj	1131	74	Ser625	Ser625	-LRB-
cord-000248-zueoyesj	1131	75	is	be	VBZ
cord-000248-zueoyesj	1131	76	essential	essential	JJ
cord-000248-zueoyesj	1131	77	to	to	TO
cord-000248-zueoyesj	1131	78	spindle	spindle	VB
cord-000248-zueoyesj	1131	79	formation	formation	NN
cord-000248-zueoyesj	1131	80	and	and	CC
cord-000248-zueoyesj	1131	81	mitosis	mitosis	NN
cord-000248-zueoyesj	1132	1	ASAP	asap	RB
cord-000248-zueoyesj	1132	2	,	,	,
cord-000248-zueoyesj	1133	1	a	a	DT
cord-000248-zueoyesj	1133	2	human	human	JJ
cord-000248-zueoyesj	1133	3	microtubule	microtubule	NN
cord-000248-zueoyesj	1133	4	-	-	HYPH
cord-000248-zueoyesj	1133	5	associated	associate	VBN
cord-000248-zueoyesj	1133	6	protein	protein	NN
cord-000248-zueoyesj	1133	7	required	require	VBN
cord-000248-zueoyesj	1133	8	for	for	IN
cord-000248-zueoyesj	1133	9	bipolar	bipolar	JJ
cord-000248-zueoyesj	1133	10	spindle	spindle	NN
cord-000248-zueoyesj	1133	11	assembly	assembly	NN
cord-000248-zueoyesj	1133	12	and	and	CC
cord-000248-zueoyesj	1133	13	cytokinesis	cytokinesis	VB
cord-000248-zueoyesj	1133	14	Comprehensive	comprehensive	JJ
cord-000248-zueoyesj	1133	15	expression	expression	NN
cord-000248-zueoyesj	1133	16	profiling	profiling	NN
cord-000248-zueoyesj	1133	17	of	of	IN
cord-000248-zueoyesj	1133	18	tumor	tumor	NN
cord-000248-zueoyesj	1133	19	cell	cell	NN
cord-000248-zueoyesj	1133	20	lines	line	NNS
cord-000248-zueoyesj	1133	21	identifies	identify	VBZ
cord-000248-zueoyesj	1133	22	molecular	molecular	JJ
cord-000248-zueoyesj	1133	23	signatures	signature	NNS
cord-000248-zueoyesj	1133	24	of	of	IN
cord-000248-zueoyesj	1133	25	melanoma	melanoma	NN
cord-000248-zueoyesj	1133	26	progression	progression	NN
cord-000248-zueoyesj	1134	1	The	the	DT
cord-000248-zueoyesj	1134	2	Nek6	Nek6	NNP
cord-000248-zueoyesj	1134	3	and	and	CC
cord-000248-zueoyesj	1134	4	Nek7	Nek7	NNP
cord-000248-zueoyesj	1134	5	protein	protein	NN
cord-000248-zueoyesj	1134	6	kinases	kinase	NNS
cord-000248-zueoyesj	1134	7	are	be	VBP
cord-000248-zueoyesj	1134	8	required	require	VBN
cord-000248-zueoyesj	1134	9	for	for	IN
cord-000248-zueoyesj	1134	10	robust	robust	JJ
cord-000248-zueoyesj	1134	11	mitotic	mitotic	JJ
cord-000248-zueoyesj	1134	12	spindle	spindle	NN
cord-000248-zueoyesj	1134	13	formation	formation	NN
cord-000248-zueoyesj	1134	14	and	and	CC
cord-000248-zueoyesj	1134	15	cytokinesis	cytokinesis	NN
cord-000248-zueoyesj	1135	1	The	the	DT
cord-000248-zueoyesj	1135	2	NIMAfamily	NIMAfamily	NNP
cord-000248-zueoyesj	1135	3	kinase	kinase	NNP
cord-000248-zueoyesj	1135	4	Nek6	Nek6	NNP
cord-000248-zueoyesj	1135	5	phosphorylates	phosphorylate	VBZ
cord-000248-zueoyesj	1135	6	the	the	DT
cord-000248-zueoyesj	1135	7	kinesin	kinesin	NN
cord-000248-zueoyesj	1135	8	Eg5	eg5	CD
cord-000248-zueoyesj	1135	9	at	at	IN
cord-000248-zueoyesj	1135	10	a	a	DT
cord-000248-zueoyesj	1135	11	novel	novel	NN
cord-000248-zueoyesj	1135	12	site	site	NN
cord-000248-zueoyesj	1135	13	necessary	necessary	JJ
cord-000248-zueoyesj	1135	14	for	for	IN
cord-000248-zueoyesj	1135	15	mitotic	mitotic	JJ
cord-000248-zueoyesj	1135	16	spindle	spindle	NN
cord-000248-zueoyesj	1135	17	formation	formation	NN
cord-000248-zueoyesj	1135	18	Integrative	integrative	JJ
cord-000248-zueoyesj	1135	19	approach	approach	NN
cord-000248-zueoyesj	1135	20	for	for	IN
cord-000248-zueoyesj	1135	21	differentially	differentially	RB
cord-000248-zueoyesj	1135	22	overexpressed	overexpresse	VBN
cord-000248-zueoyesj	1135	23	genes	gene	NNS
cord-000248-zueoyesj	1135	24	in	in	IN
cord-000248-zueoyesj	1135	25	gastric	gastric	JJ
cord-000248-zueoyesj	1135	26	cancer	cancer	NN
cord-000248-zueoyesj	1135	27	by	by	IN
cord-000248-zueoyesj	1135	28	combining	combine	VBG
cord-000248-zueoyesj	1135	29	large	large	JJ
cord-000248-zueoyesj	1135	30	-	-	HYPH
cord-000248-zueoyesj	1135	31	scale	scale	NN
cord-000248-zueoyesj	1135	32	gene	gene	NN
cord-000248-zueoyesj	1135	33	expression	expression	NN
cord-000248-zueoyesj	1135	34	profiling	profiling	NN
cord-000248-zueoyesj	1135	35	and	and	CC
cord-000248-zueoyesj	1135	36	network	network	NN
cord-000248-zueoyesj	1135	37	analysis	analysis	NN
cord-000248-zueoyesj	1136	1	Nek6	Nek6	NNP
cord-000248-zueoyesj	1136	2	is	be	VBZ
cord-000248-zueoyesj	1136	3	involved	involve	VBN
cord-000248-zueoyesj	1136	4	in	in	IN
cord-000248-zueoyesj	1136	5	G2	G2	NNP
cord-000248-zueoyesj	1136	6	/	/	SYM
cord-000248-zueoyesj	1136	7	M	M	NNP
cord-000248-zueoyesj	1136	8	phase	phase	NN
cord-000248-zueoyesj	1136	9	cell	cell	NN
cord-000248-zueoyesj	1136	10	cycle	cycle	NN
cord-000248-zueoyesj	1136	11	arrest	arrest	NN
cord-000248-zueoyesj	1136	12	through	through	IN
cord-000248-zueoyesj	1136	13	DNA	dna	NN
cord-000248-zueoyesj	1136	14	damage	damage	NN
cord-000248-zueoyesj	1136	15	-	-	HYPH
cord-000248-zueoyesj	1136	16	induced	induce	VBN
cord-000248-zueoyesj	1136	17	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	1137	1	Polo	polo	NN
cord-000248-zueoyesj	1137	2	-	-	HYPH
cord-000248-zueoyesj	1137	3	like	like	JJ
cord-000248-zueoyesj	1137	4	kinase	kinase	NN
cord-000248-zueoyesj	1137	5	1	1	CD
cord-000248-zueoyesj	1138	1	(	(	-LRB-
cord-000248-zueoyesj	1138	2	Plk1	Plk1	NNP
cord-000248-zueoyesj	1138	3	)	)	-RRB-
cord-000248-zueoyesj	1138	4	in	in	IN
cord-000248-zueoyesj	1138	5	non	non	JJ
cord-000248-zueoyesj	1138	6	-	-	JJ
cord-000248-zueoyesj	1138	7	melanoma	melanoma	JJ
cord-000248-zueoyesj	1138	8	skin	skin	NN
cord-000248-zueoyesj	1138	9	cancers	cancer	NNS
cord-000248-zueoyesj	1139	1	Targeted	target	VBN
cord-000248-zueoyesj	1139	2	Depletion	depletion	NN
cord-000248-zueoyesj	1139	3	of	of	IN
cord-000248-zueoyesj	1140	1	Polo	Polo	NNP
cord-000248-zueoyesj	1140	2	-	-	HYPH
cord-000248-zueoyesj	1140	3	Like	Like	NNP
cord-000248-zueoyesj	1140	4	Kinase	Kinase	NNP
cord-000248-zueoyesj	1140	5	(	(	-LRB-
cord-000248-zueoyesj	1140	6	Plk	Plk	NNP
cord-000248-zueoyesj	1140	7	)	)	-RRB-
cord-000248-zueoyesj	1141	1	1	1	LS
cord-000248-zueoyesj	1142	1	Through	through	IN
cord-000248-zueoyesj	1142	2	Lentiviral	Lentiviral	NNP
cord-000248-zueoyesj	1142	3	shRNA	shrna	NN
cord-000248-zueoyesj	1142	4	or	or	CC
cord-000248-zueoyesj	1143	1	a	a	DT
cord-000248-zueoyesj	1143	2	Small	Small	NNP
cord-000248-zueoyesj	1143	3	-	-	HYPH
cord-000248-zueoyesj	1143	4	Molecule	molecule	NN
cord-000248-zueoyesj	1143	5	Inhibitor	inhibitor	NN
cord-000248-zueoyesj	1143	6	Causes	cause	VBZ
cord-000248-zueoyesj	1143	7	Mitotic	Mitotic	NNP
cord-000248-zueoyesj	1143	8	Catastrophe	Catastrophe	NNP
cord-000248-zueoyesj	1143	9	and	and	CC
cord-000248-zueoyesj	1143	10	Induction	Induction	NNP
cord-000248-zueoyesj	1143	11	of	of	IN
cord-000248-zueoyesj	1143	12	Apoptosis	Apoptosis	NNP
cord-000248-zueoyesj	1143	13	in	in	IN
cord-000248-zueoyesj	1143	14	Human	Human	NNP
cord-000248-zueoyesj	1143	15	Melanoma	Melanoma	NNP
cord-000248-zueoyesj	1143	16	Cells	cell	NNS
cord-000248-zueoyesj	1143	17	Expression	expression	NN
cord-000248-zueoyesj	1143	18	and	and	CC
cord-000248-zueoyesj	1143	19	possible	possible	JJ
cord-000248-zueoyesj	1143	20	role	role	NN
cord-000248-zueoyesj	1143	21	of	of	IN
cord-000248-zueoyesj	1143	22	hPTTG1	hpttg1	NN
cord-000248-zueoyesj	1143	23	/	/	SYM
cord-000248-zueoyesj	1143	24	securin	securin	NN
cord-000248-zueoyesj	1143	25	in	in	IN
cord-000248-zueoyesj	1143	26	cutaneous	cutaneous	JJ
cord-000248-zueoyesj	1143	27	malignant	malignant	JJ
cord-000248-zueoyesj	1143	28	melanoma	melanoma	NN
cord-000248-zueoyesj	1143	29	Antagonism	antagonism	NN
cord-000248-zueoyesj	1143	30	of	of	IN
cord-000248-zueoyesj	1143	31	p66shc	p66shc	NNP
cord-000248-zueoyesj	1143	32	by	by	IN
cord-000248-zueoyesj	1143	33	melanoma	melanoma	NN
cord-000248-zueoyesj	1143	34	inhibitory	inhibitory	JJ
cord-000248-zueoyesj	1143	35	activity	activity	NN
cord-000248-zueoyesj	1143	36	RaLP	RaLP	NNP
cord-000248-zueoyesj	1143	37	,	,	,
cord-000248-zueoyesj	1143	38	a	a	DT
cord-000248-zueoyesj	1143	39	new	new	JJ
cord-000248-zueoyesj	1143	40	member	member	NN
cord-000248-zueoyesj	1143	41	of	of	IN
cord-000248-zueoyesj	1143	42	the	the	DT
cord-000248-zueoyesj	1143	43	Src	Src	NNP
cord-000248-zueoyesj	1143	44	homology	homology	NN
cord-000248-zueoyesj	1143	45	and	and	CC
cord-000248-zueoyesj	1143	46	collagen	collagen	NN
cord-000248-zueoyesj	1143	47	family	family	NN
cord-000248-zueoyesj	1143	48	,	,	,
cord-000248-zueoyesj	1143	49	regulates	regulate	VBZ
cord-000248-zueoyesj	1143	50	cell	cell	NN
cord-000248-zueoyesj	1143	51	migration	migration	NN
cord-000248-zueoyesj	1143	52	and	and	CC
cord-000248-zueoyesj	1143	53	tumor	tumor	NN
cord-000248-zueoyesj	1143	54	growth	growth	NN
cord-000248-zueoyesj	1143	55	of	of	IN
cord-000248-zueoyesj	1143	56	metastatic	metastatic	JJ
cord-000248-zueoyesj	1143	57	melanomas	melanoma	NNS
cord-000248-zueoyesj	1143	58	Melanoma	melanoma	NN
cord-000248-zueoyesj	1143	59	:	:	:
cord-000248-zueoyesj	1143	60	targeting	target	VBG
cord-000248-zueoyesj	1143	61	signaling	signal	VBG
cord-000248-zueoyesj	1143	62	pathways	pathway	NNS
cord-000248-zueoyesj	1143	63	and	and	CC
cord-000248-zueoyesj	1144	1	RaLP	RaLP	NNP
cord-000248-zueoyesj	1144	2	Deregulated	deregulate	VBN
cord-000248-zueoyesj	1144	3	E2F	e2f	NN
cord-000248-zueoyesj	1144	4	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1144	5	activity	activity	NN
cord-000248-zueoyesj	1144	6	in	in	IN
cord-000248-zueoyesj	1144	7	autonomously	autonomously	RB
cord-000248-zueoyesj	1144	8	growing	grow	VBG
cord-000248-zueoyesj	1144	9	melanoma	melanoma	NN
cord-000248-zueoyesj	1144	10	cells	cell	NNS
cord-000248-zueoyesj	1145	1	Arpc1b	Arpc1b	NNP
cord-000248-zueoyesj	1145	2	gene	gene	NN
cord-000248-zueoyesj	1145	3	is	be	VBZ
cord-000248-zueoyesj	1145	4	a	a	DT
cord-000248-zueoyesj	1145	5	candidate	candidate	NN
cord-000248-zueoyesj	1145	6	prediction	prediction	NN
cord-000248-zueoyesj	1145	7	marker	marker	NN
cord-000248-zueoyesj	1145	8	for	for	IN
cord-000248-zueoyesj	1145	9	choroidal	choroidal	JJ
cord-000248-zueoyesj	1145	10	malignant	malignant	JJ
cord-000248-zueoyesj	1145	11	melanomas	melanoma	NNS
cord-000248-zueoyesj	1145	12	sensitive	sensitive	JJ
cord-000248-zueoyesj	1145	13	to	to	IN
cord-000248-zueoyesj	1145	14	radiotherapy	radiotherapy	NN
cord-000248-zueoyesj	1146	1	A	a	DT
cord-000248-zueoyesj	1146	2	multi	multi	JJ
cord-000248-zueoyesj	1146	3	-	-	JJ
cord-000248-zueoyesj	1146	4	marker	marker	JJ
cord-000248-zueoyesj	1146	5	assay	assay	NN
cord-000248-zueoyesj	1146	6	to	to	TO
cord-000248-zueoyesj	1146	7	distinguish	distinguish	VB
cord-000248-zueoyesj	1146	8	malignant	malignant	JJ
cord-000248-zueoyesj	1146	9	melanomas	melanoma	NNS
cord-000248-zueoyesj	1146	10	from	from	IN
cord-000248-zueoyesj	1146	11	benign	benign	JJ
cord-000248-zueoyesj	1146	12	nevi	nevus	NNS
cord-000248-zueoyesj	1146	13	BCCIP	BCCIP	NNP
cord-000248-zueoyesj	1146	14	functions	function	NNS
cord-000248-zueoyesj	1146	15	through	through	IN
cord-000248-zueoyesj	1146	16	p53	p53	NN
cord-000248-zueoyesj	1146	17	to	to	TO
cord-000248-zueoyesj	1146	18	regulate	regulate	VB
cord-000248-zueoyesj	1146	19	the	the	DT
cord-000248-zueoyesj	1146	20	expression	expression	NN
cord-000248-zueoyesj	1146	21	of	of	IN
cord-000248-zueoyesj	1146	22	p21Waf1	p21waf1	CD
cord-000248-zueoyesj	1146	23	/	/	SYM
cord-000248-zueoyesj	1146	24	Cip1	Cip1	NNP
cord-000248-zueoyesj	1146	25	Identification	Identification	NNP
cord-000248-zueoyesj	1146	26	of	of	IN
cord-000248-zueoyesj	1146	27	genes	gene	NNS
cord-000248-zueoyesj	1146	28	expressed	express	VBN
cord-000248-zueoyesj	1146	29	in	in	IN
cord-000248-zueoyesj	1146	30	malignant	malignant	JJ
cord-000248-zueoyesj	1146	31	cells	cell	NNS
cord-000248-zueoyesj	1146	32	that	that	WDT
cord-000248-zueoyesj	1146	33	promote	promote	VBP
cord-000248-zueoyesj	1146	34	invasion	invasion	NN
cord-000248-zueoyesj	1146	35	Chemokine	chemokine	JJ
cord-000248-zueoyesj	1146	36	expression	expression	NN
cord-000248-zueoyesj	1146	37	in	in	IN
cord-000248-zueoyesj	1146	38	melanoma	melanoma	NN
cord-000248-zueoyesj	1146	39	metastases	metastasis	NNS
cord-000248-zueoyesj	1146	40	associated	associate	VBN
cord-000248-zueoyesj	1146	41	with	with	IN
cord-000248-zueoyesj	1146	42	CD8	CD8	NNP
cord-000248-zueoyesj	1146	43	+	+	CC
cord-000248-zueoyesj	1146	44	T	T	NNP
cord-000248-zueoyesj	1146	45	-	-	HYPH
cord-000248-zueoyesj	1146	46	cell	cell	NN
cord-000248-zueoyesj	1146	47	recruitment	recruitment	NN
cord-000248-zueoyesj	1146	48	A	a	DT
cord-000248-zueoyesj	1146	49	potential	potential	JJ
cord-000248-zueoyesj	1146	50	immune	immune	JJ
cord-000248-zueoyesj	1146	51	escape	escape	NN
cord-000248-zueoyesj	1146	52	mechanism	mechanism	NN
cord-000248-zueoyesj	1146	53	by	by	IN
cord-000248-zueoyesj	1146	54	melanoma	melanoma	NN
cord-000248-zueoyesj	1146	55	cells	cell	NNS
cord-000248-zueoyesj	1146	56	through	through	IN
cord-000248-zueoyesj	1146	57	the	the	DT
cord-000248-zueoyesj	1146	58	activation	activation	NN
cord-000248-zueoyesj	1146	59	of	of	IN
cord-000248-zueoyesj	1146	60	chemokine	chemokine	NN
cord-000248-zueoyesj	1146	61	-	-	HYPH
cord-000248-zueoyesj	1146	62	induced	induce	VBN
cord-000248-zueoyesj	1146	63	T	t	NN
cord-000248-zueoyesj	1146	64	cell	cell	NN
cord-000248-zueoyesj	1146	65	death	death	NN
cord-000248-zueoyesj	1146	66	Multiplex	Multiplex	NNP
cord-000248-zueoyesj	1146	67	analysis	analysis	NN
cord-000248-zueoyesj	1146	68	of	of	IN
cord-000248-zueoyesj	1146	69	serum	serum	NN
cord-000248-zueoyesj	1146	70	cytokines	cytokine	NNS
cord-000248-zueoyesj	1146	71	in	in	IN
cord-000248-zueoyesj	1146	72	melanoma	melanoma	NN
cord-000248-zueoyesj	1146	73	patients	patient	NNS
cord-000248-zueoyesj	1146	74	treated	treat	VBN
cord-000248-zueoyesj	1146	75	with	with	IN
cord-000248-zueoyesj	1146	76	interferon	interferon	NN
cord-000248-zueoyesj	1146	77	-	-	HYPH
cord-000248-zueoyesj	1146	78	alpha2b	alpha2b	NNP
cord-000248-zueoyesj	1146	79	Regulation	Regulation	NNP
cord-000248-zueoyesj	1146	80	of	of	IN
cord-000248-zueoyesj	1146	81	centromeric	centromeric	JJ
cord-000248-zueoyesj	1146	82	cohesion	cohesion	NN
cord-000248-zueoyesj	1146	83	by	by	IN
cord-000248-zueoyesj	1146	84	sororin	sororin	NNP
cord-000248-zueoyesj	1146	85	independently	independently	RB
cord-000248-zueoyesj	1146	86	of	of	IN
cord-000248-zueoyesj	1146	87	the	the	DT
cord-000248-zueoyesj	1146	88	APC	APC	NNP
cord-000248-zueoyesj	1146	89	/	/	SYM
cord-000248-zueoyesj	1146	90	C	C	NNP
cord-000248-zueoyesj	1146	91	Sororin	Sororin	NNP
cord-000248-zueoyesj	1146	92	is	be	VBZ
cord-000248-zueoyesj	1146	93	required	require	VBN
cord-000248-zueoyesj	1146	94	for	for	IN
cord-000248-zueoyesj	1146	95	stable	stable	JJ
cord-000248-zueoyesj	1146	96	binding	binding	NN
cord-000248-zueoyesj	1146	97	of	of	IN
cord-000248-zueoyesj	1146	98	cohesin	cohesin	NNS
cord-000248-zueoyesj	1146	99	to	to	TO
cord-000248-zueoyesj	1146	100	chromatin	chromatin	VB
cord-000248-zueoyesj	1146	101	and	and	CC
cord-000248-zueoyesj	1146	102	for	for	IN
cord-000248-zueoyesj	1146	103	sister	sister	NN
cord-000248-zueoyesj	1146	104	chromatid	chromatid	JJ
cord-000248-zueoyesj	1146	105	cohesion	cohesion	NN
cord-000248-zueoyesj	1146	106	in	in	IN
cord-000248-zueoyesj	1146	107	interphase	interphase	NN
cord-000248-zueoyesj	1146	108	Sororin	Sororin	NNP
cord-000248-zueoyesj	1146	109	,	,	,
cord-000248-zueoyesj	1146	110	the	the	DT
cord-000248-zueoyesj	1146	111	cell	cell	NN
cord-000248-zueoyesj	1146	112	cycle	cycle	NN
cord-000248-zueoyesj	1146	113	and	and	CC
cord-000248-zueoyesj	1146	114	sister	sister	NN
cord-000248-zueoyesj	1146	115	chromatid	chromatid	JJ
cord-000248-zueoyesj	1146	116	cohesion	cohesion	NN
cord-000248-zueoyesj	1146	117	Sororin	Sororin	NNP
cord-000248-zueoyesj	1146	118	,	,	,
cord-000248-zueoyesj	1146	119	a	a	DT
cord-000248-zueoyesj	1146	120	substrate	substrate	NN
cord-000248-zueoyesj	1146	121	of	of	IN
cord-000248-zueoyesj	1146	122	the	the	DT
cord-000248-zueoyesj	1146	123	anaphase	anaphase	NN
cord-000248-zueoyesj	1146	124	-	-	HYPH
cord-000248-zueoyesj	1146	125	promoting	promote	VBG
cord-000248-zueoyesj	1146	126	complex	complex	NN
cord-000248-zueoyesj	1146	127	,	,	,
cord-000248-zueoyesj	1146	128	is	be	VBZ
cord-000248-zueoyesj	1146	129	required	require	VBN
cord-000248-zueoyesj	1146	130	for	for	IN
cord-000248-zueoyesj	1146	131	sister	sister	NN
cord-000248-zueoyesj	1146	132	chromatid	chromatid	JJ
cord-000248-zueoyesj	1146	133	cohesion	cohesion	NN
cord-000248-zueoyesj	1146	134	in	in	IN
cord-000248-zueoyesj	1146	135	vertebrates	vertebrate	NNS
cord-000248-zueoyesj	1147	1	Cooperative	cooperative	JJ
cord-000248-zueoyesj	1147	2	roles	role	NNS
cord-000248-zueoyesj	1147	3	of	of	IN
cord-000248-zueoyesj	1147	4	c	c	NN
cord-000248-zueoyesj	1147	5	-	-	:
cord-000248-zueoyesj	1147	6	Abl	Abl	NNP
cord-000248-zueoyesj	1147	7	and	and	CC
cord-000248-zueoyesj	1147	8	Cdk5	Cdk5	NNP
cord-000248-zueoyesj	1147	9	in	in	IN
cord-000248-zueoyesj	1147	10	regulation	regulation	NN
cord-000248-zueoyesj	1147	11	of	of	IN
cord-000248-zueoyesj	1147	12	p53	p53	NN
cord-000248-zueoyesj	1147	13	in	in	IN
cord-000248-zueoyesj	1147	14	response	response	NN
cord-000248-zueoyesj	1147	15	to	to	IN
cord-000248-zueoyesj	1147	16	oxidative	oxidative	JJ
cord-000248-zueoyesj	1147	17	stress	stress	NN
cord-000248-zueoyesj	1147	18	Gene	Gene	NNP
cord-000248-zueoyesj	1147	19	expression	expression	NN
cord-000248-zueoyesj	1147	20	signatures	signature	NNS
cord-000248-zueoyesj	1147	21	for	for	IN
cord-000248-zueoyesj	1147	22	tumor	tumor	NN
cord-000248-zueoyesj	1147	23	progression	progression	NN
cord-000248-zueoyesj	1147	24	,	,	,
cord-000248-zueoyesj	1147	25	tumor	tumor	NN
cord-000248-zueoyesj	1147	26	subtype	subtype	NN
cord-000248-zueoyesj	1147	27	,	,	,
cord-000248-zueoyesj	1147	28	and	and	CC
cord-000248-zueoyesj	1147	29	tumor	tumor	NN
cord-000248-zueoyesj	1147	30	thickness	thickness	NN
cord-000248-zueoyesj	1147	31	in	in	IN
cord-000248-zueoyesj	1147	32	laser	laser	NN
cord-000248-zueoyesj	1147	33	-	-	HYPH
cord-000248-zueoyesj	1147	34	microdissected	microdissecte	VBN
cord-000248-zueoyesj	1147	35	melanoma	melanoma	NN
cord-000248-zueoyesj	1147	36	tissues	tissue	VBZ
cord-000248-zueoyesj	1147	37	A	a	DT
cord-000248-zueoyesj	1147	38	receptor	receptor	NN
cord-000248-zueoyesj	1147	39	for	for	IN
cord-000248-zueoyesj	1147	40	the	the	DT
cord-000248-zueoyesj	1147	41	malarial	malarial	JJ
cord-000248-zueoyesj	1147	42	parasite	parasite	NN
cord-000248-zueoyesj	1147	43	Plasmodium	plasmodium	NN
cord-000248-zueoyesj	1147	44	vivax	vivax	NN
cord-000248-zueoyesj	1147	45	:	:	:
cord-000248-zueoyesj	1148	1	the	the	DT
cord-000248-zueoyesj	1148	2	erythrocyte	erythrocyte	NN
cord-000248-zueoyesj	1148	3	chemokine	chemokine	NN
cord-000248-zueoyesj	1148	4	receptor	receptor	NN
cord-000248-zueoyesj	1148	5	MGSA	MGSA	NNP
cord-000248-zueoyesj	1148	6	/	/	SYM
cord-000248-zueoyesj	1148	7	GRO	gro	NN
cord-000248-zueoyesj	1148	8	transcription	transcription	NN
cord-000248-zueoyesj	1148	9	is	be	VBZ
cord-000248-zueoyesj	1148	10	differentially	differentially	RB
cord-000248-zueoyesj	1148	11	regulated	regulate	VBN
cord-000248-zueoyesj	1148	12	in	in	IN
cord-000248-zueoyesj	1148	13	normal	normal	JJ
cord-000248-zueoyesj	1148	14	retinal	retinal	JJ
cord-000248-zueoyesj	1148	15	pigment	pigment	NN
cord-000248-zueoyesj	1148	16	epithelial	epithelial	NN
cord-000248-zueoyesj	1148	17	and	and	CC
cord-000248-zueoyesj	1148	18	melanoma	melanoma	NN
cord-000248-zueoyesj	1148	19	cells	cell	NNS
cord-000248-zueoyesj	1148	20	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1148	21	factor	factor	NN
cord-000248-zueoyesj	1148	22	-	-	HYPH
cord-000248-zueoyesj	1148	23	kappa	kappa	NN
cord-000248-zueoyesj	1148	24	B	B	NNP
cord-000248-zueoyesj	1148	25	activation	activation	NN
cord-000248-zueoyesj	1148	26	by	by	IN
cord-000248-zueoyesj	1148	27	the	the	DT
cord-000248-zueoyesj	1148	28	CXC	CXC	NNP
cord-000248-zueoyesj	1148	29	chemokine	chemokine	NN
cord-000248-zueoyesj	1148	30	melanoma	melanoma	NN
cord-000248-zueoyesj	1148	31	growth	growth	NN
cord-000248-zueoyesj	1148	32	-	-	HYPH
cord-000248-zueoyesj	1148	33	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1148	34	activity	activity	NN
cord-000248-zueoyesj	1148	35	/	/	SYM
cord-000248-zueoyesj	1148	36	growth	growth	NN
cord-000248-zueoyesj	1148	37	-	-	HYPH
cord-000248-zueoyesj	1148	38	regulated	regulate	VBN
cord-000248-zueoyesj	1148	39	protein	protein	NN
cord-000248-zueoyesj	1148	40	involves	involve	VBZ
cord-000248-zueoyesj	1148	41	the	the	DT
cord-000248-zueoyesj	1148	42	MEKK1	mekk1	NN
cord-000248-zueoyesj	1148	43	/	/	SYM
cord-000248-zueoyesj	1148	44	p38	p38	CD
cord-000248-zueoyesj	1148	45	mitogen	mitogen	NN
cord-000248-zueoyesj	1148	46	-	-	HYPH
cord-000248-zueoyesj	1148	47	activated	activate	VBN
cord-000248-zueoyesj	1148	48	protein	protein	NN
cord-000248-zueoyesj	1148	49	kinase	kinase	NN
cord-000248-zueoyesj	1148	50	pathway	pathway	NN
cord-000248-zueoyesj	1148	51	Endothelin-1	Endothelin-1	NNP
cord-000248-zueoyesj	1149	1	induces	induce	VBZ
cord-000248-zueoyesj	1150	1	CXCL1	CXCL1	NNP
cord-000248-zueoyesj	1150	2	and	and	CC
cord-000248-zueoyesj	1150	3	CXCL8	CXCL8	NNP
cord-000248-zueoyesj	1150	4	secretion	secretion	NN
cord-000248-zueoyesj	1150	5	in	in	IN
cord-000248-zueoyesj	1150	6	human	human	JJ
cord-000248-zueoyesj	1150	7	melanoma	melanoma	NN
cord-000248-zueoyesj	1150	8	cells	cell	NNS
cord-000248-zueoyesj	1150	9	Gene	Gene	NNP
cord-000248-zueoyesj	1150	10	expression	expression	NN
cord-000248-zueoyesj	1150	11	profiling	profiling	NN
cord-000248-zueoyesj	1150	12	reveals	reveal	VBZ
cord-000248-zueoyesj	1150	13	cross	cross	NN
cord-000248-zueoyesj	1150	14	-	-	NN
cord-000248-zueoyesj	1150	15	talk	talk	NN
cord-000248-zueoyesj	1150	16	between	between	IN
cord-000248-zueoyesj	1150	17	melanoma	melanoma	NN
cord-000248-zueoyesj	1150	18	and	and	CC
cord-000248-zueoyesj	1150	19	fibroblasts	fibroblast	NNS
cord-000248-zueoyesj	1150	20	:	:	:
cord-000248-zueoyesj	1150	21	implications	implication	NNS
cord-000248-zueoyesj	1150	22	for	for	IN
cord-000248-zueoyesj	1150	23	host	host	NN
cord-000248-zueoyesj	1150	24	-	-	HYPH
cord-000248-zueoyesj	1150	25	tumor	tumor	NN
cord-000248-zueoyesj	1150	26	interactions	interaction	NNS
cord-000248-zueoyesj	1150	27	in	in	IN
cord-000248-zueoyesj	1150	28	metastasis	metastasis	NN
cord-000248-zueoyesj	1151	1	Threedimensional	threedimensional	JJ
cord-000248-zueoyesj	1151	2	culture	culture	NN
cord-000248-zueoyesj	1151	3	of	of	IN
cord-000248-zueoyesj	1151	4	melanoma	melanoma	NN
cord-000248-zueoyesj	1151	5	cells	cell	NNS
cord-000248-zueoyesj	1151	6	profoundly	profoundly	RB
cord-000248-zueoyesj	1151	7	affects	affect	VBZ
cord-000248-zueoyesj	1151	8	gene	gene	NN
cord-000248-zueoyesj	1151	9	expression	expression	NN
cord-000248-zueoyesj	1151	10	profile	profile	NN
cord-000248-zueoyesj	1151	11	:	:	:
cord-000248-zueoyesj	1151	12	a	a	DT
cord-000248-zueoyesj	1151	13	high	high	JJ
cord-000248-zueoyesj	1151	14	density	density	NN
cord-000248-zueoyesj	1151	15	oligonucleotide	oligonucleotide	IN
cord-000248-zueoyesj	1151	16	array	array	NN
cord-000248-zueoyesj	1151	17	study	study	NN
cord-000248-zueoyesj	1151	18	Evidence	evidence	NN
cord-000248-zueoyesj	1151	19	of	of	IN
cord-000248-zueoyesj	1151	20	involvement	involvement	NN
cord-000248-zueoyesj	1151	21	of	of	IN
cord-000248-zueoyesj	1151	22	CXC	CXC	NNP
cord-000248-zueoyesj	1151	23	-	-	HYPH
cord-000248-zueoyesj	1151	24	chemokines	chemokine	NNS
cord-000248-zueoyesj	1151	25	in	in	IN
cord-000248-zueoyesj	1151	26	proliferation	proliferation	NN
cord-000248-zueoyesj	1151	27	of	of	IN
cord-000248-zueoyesj	1151	28	cultivated	cultivate	VBN
cord-000248-zueoyesj	1151	29	human	human	JJ
cord-000248-zueoyesj	1151	30	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1151	31	Role	role	NN
cord-000248-zueoyesj	1151	32	of	of	IN
cord-000248-zueoyesj	1151	33	CXCL1	CXCL1	NNP
cord-000248-zueoyesj	1151	34	in	in	IN
cord-000248-zueoyesj	1151	35	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1151	36	of	of	IN
cord-000248-zueoyesj	1151	37	melanoma	melanoma	NN
cord-000248-zueoyesj	1151	38	Melanoma	melanoma	NN
cord-000248-zueoyesj	1151	39	growth	growth	NN
cord-000248-zueoyesj	1151	40	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1151	41	activity	activity	NN
cord-000248-zueoyesj	1151	42	in	in	IN
cord-000248-zueoyesj	1151	43	primary	primary	JJ
cord-000248-zueoyesj	1151	44	malignant	malignant	JJ
cord-000248-zueoyesj	1151	45	melanoma	melanoma	NN
cord-000248-zueoyesj	1151	46	:	:	:
cord-000248-zueoyesj	1151	47	prognostic	prognostic	JJ
cord-000248-zueoyesj	1151	48	significance	significance	NN
cord-000248-zueoyesj	1152	1	A	a	DT
cord-000248-zueoyesj	1152	2	novel	novel	JJ
cord-000248-zueoyesj	1152	3	NF	nf	NN
cord-000248-zueoyesj	1152	4	-	-	HYPH
cord-000248-zueoyesj	1152	5	kappa	kappa	NN
cord-000248-zueoyesj	1152	6	B	b	NN
cord-000248-zueoyesj	1152	7	-	-	HYPH
cord-000248-zueoyesj	1152	8	inducing	induce	VBG
cord-000248-zueoyesj	1152	9	kinase	kinase	NN
cord-000248-zueoyesj	1152	10	-	-	:
cord-000248-zueoyesj	1152	11	MAPK	MAPK	NNP
cord-000248-zueoyesj	1152	12	signaling	signal	VBG
cord-000248-zueoyesj	1152	13	pathway	pathway	NN
cord-000248-zueoyesj	1152	14	up	up	RB
cord-000248-zueoyesj	1152	15	-	-	HYPH
cord-000248-zueoyesj	1152	16	regulates	regulate	VBZ
cord-000248-zueoyesj	1152	17	NF	nf	NN
cord-000248-zueoyesj	1152	18	-	-	HYPH
cord-000248-zueoyesj	1152	19	kappa	kappa	NN
cord-000248-zueoyesj	1152	20	B	b	NN
cord-000248-zueoyesj	1152	21	activity	activity	NN
cord-000248-zueoyesj	1152	22	in	in	IN
cord-000248-zueoyesj	1152	23	melanoma	melanoma	NN
cord-000248-zueoyesj	1152	24	cells	cell	NNS
cord-000248-zueoyesj	1152	25	Induction	induction	NN
cord-000248-zueoyesj	1152	26	of	of	IN
cord-000248-zueoyesj	1152	27	melanoma	melanoma	NN
cord-000248-zueoyesj	1152	28	in	in	IN
cord-000248-zueoyesj	1152	29	murine	murine	JJ
cord-000248-zueoyesj	1152	30	macrophage	macrophage	NN
cord-000248-zueoyesj	1152	31	inflammatory	inflammatory	JJ
cord-000248-zueoyesj	1152	32	protein	protein	NN
cord-000248-zueoyesj	1152	33	2	2	CD
cord-000248-zueoyesj	1152	34	transgenic	transgenic	JJ
cord-000248-zueoyesj	1152	35	mice	mouse	NNS
cord-000248-zueoyesj	1152	36	heterozygous	heterozygous	JJ
cord-000248-zueoyesj	1152	37	for	for	IN
cord-000248-zueoyesj	1152	38	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1152	39	of	of	IN
cord-000248-zueoyesj	1152	40	kinase	kinase	NN
cord-000248-zueoyesj	1152	41	/	/	SYM
cord-000248-zueoyesj	1152	42	alternate	alternate	JJ
cord-000248-zueoyesj	1152	43	reading	reading	NN
cord-000248-zueoyesj	1152	44	frame	frame	NN
cord-000248-zueoyesj	1153	1	Constitutive	constitutive	JJ
cord-000248-zueoyesj	1153	2	IkappaB	IkappaB	NNP
cord-000248-zueoyesj	1153	3	kinase	kinase	VBZ
cord-000248-zueoyesj	1153	4	activity	activity	NN
cord-000248-zueoyesj	1153	5	correlates	correlate	VBZ
cord-000248-zueoyesj	1153	6	with	with	IN
cord-000248-zueoyesj	1153	7	nuclear	nuclear	JJ
cord-000248-zueoyesj	1153	8	factor	factor	NN
cord-000248-zueoyesj	1153	9	-	-	:
cord-000248-zueoyesj	1153	10	kappaB	kappaB	NNP
cord-000248-zueoyesj	1153	11	activation	activation	NN
cord-000248-zueoyesj	1153	12	in	in	IN
cord-000248-zueoyesj	1153	13	human	human	JJ
cord-000248-zueoyesj	1153	14	melanoma	melanoma	NN
cord-000248-zueoyesj	1153	15	cells	cell	NNS
cord-000248-zueoyesj	1154	1	MGSA	MGSA	NNP
cord-000248-zueoyesj	1154	2	/	/	SYM
cord-000248-zueoyesj	1154	3	GROmediated	gromediated	JJ
cord-000248-zueoyesj	1154	4	melanocyte	melanocyte	NN
cord-000248-zueoyesj	1154	5	transformation	transformation	NN
cord-000248-zueoyesj	1154	6	involves	involve	VBZ
cord-000248-zueoyesj	1154	7	induction	induction	NN
cord-000248-zueoyesj	1154	8	of	of	IN
cord-000248-zueoyesj	1154	9	Ras	Ras	NNP
cord-000248-zueoyesj	1154	10	expression	expression	NN
cord-000248-zueoyesj	1155	1	The	the	DT
cord-000248-zueoyesj	1155	2	tumorigenic	tumorigenic	JJ
cord-000248-zueoyesj	1155	3	and	and	CC
cord-000248-zueoyesj	1155	4	angiogenic	angiogenic	JJ
cord-000248-zueoyesj	1155	5	effects	effect	NNS
cord-000248-zueoyesj	1155	6	of	of	IN
cord-000248-zueoyesj	1155	7	MGSA	MGSA	NNP
cord-000248-zueoyesj	1155	8	/	/	SYM
cord-000248-zueoyesj	1155	9	GRO	GRO	NNP
cord-000248-zueoyesj	1155	10	proteins	protein	NNS
cord-000248-zueoyesj	1155	11	in	in	IN
cord-000248-zueoyesj	1155	12	melanoma	melanoma	NN
cord-000248-zueoyesj	1155	13	Autocrine	Autocrine	NNP
cord-000248-zueoyesj	1155	14	and	and	CC
cord-000248-zueoyesj	1155	15	paracrine	paracrine	JJ
cord-000248-zueoyesj	1155	16	roles	role	NNS
cord-000248-zueoyesj	1155	17	for	for	IN
cord-000248-zueoyesj	1155	18	growth	growth	NN
cord-000248-zueoyesj	1155	19	factors	factor	NNS
cord-000248-zueoyesj	1155	20	in	in	IN
cord-000248-zueoyesj	1155	21	melanoma	melanoma	NN
cord-000248-zueoyesj	1155	22	Localization	localization	NN
cord-000248-zueoyesj	1155	23	of	of	IN
cord-000248-zueoyesj	1155	24	MGSA	MGSA	NNP
cord-000248-zueoyesj	1155	25	/	/	SYM
cord-000248-zueoyesj	1155	26	GRO	GRO	NNP
cord-000248-zueoyesj	1155	27	protein	protein	NN
cord-000248-zueoyesj	1155	28	in	in	IN
cord-000248-zueoyesj	1155	29	cutaneous	cutaneous	JJ
cord-000248-zueoyesj	1155	30	lesions	lesion	NNS
cord-000248-zueoyesj	1156	1	Melanoma	melanoma	NN
cord-000248-zueoyesj	1156	2	growth	growth	NN
cord-000248-zueoyesj	1156	3	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1156	4	activity	activity	NN
cord-000248-zueoyesj	1156	5	:	:	:
cord-000248-zueoyesj	1156	6	isolation	isolation	NN
cord-000248-zueoyesj	1156	7	from	from	IN
cord-000248-zueoyesj	1156	8	human	human	JJ
cord-000248-zueoyesj	1156	9	melanoma	melanoma	NN
cord-000248-zueoyesj	1156	10	tumors	tumor	NNS
cord-000248-zueoyesj	1156	11	and	and	CC
cord-000248-zueoyesj	1156	12	characterization	characterization	NN
cord-000248-zueoyesj	1156	13	of	of	IN
cord-000248-zueoyesj	1156	14	tissue	tissue	NN
cord-000248-zueoyesj	1156	15	distribution	distribution	NN
cord-000248-zueoyesj	1156	16	Immunoaffinity	Immunoaffinity	NNP
cord-000248-zueoyesj	1156	17	purification	purification	NN
cord-000248-zueoyesj	1156	18	of	of	IN
cord-000248-zueoyesj	1156	19	melanoma	melanoma	NN
cord-000248-zueoyesj	1156	20	growth	growth	NN
cord-000248-zueoyesj	1156	21	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1156	22	activity	activity	NN
cord-000248-zueoyesj	1156	23	Characterization	characterization	NN
cord-000248-zueoyesj	1156	24	of	of	IN
cord-000248-zueoyesj	1156	25	the	the	DT
cord-000248-zueoyesj	1156	26	role	role	NN
cord-000248-zueoyesj	1156	27	of	of	IN
cord-000248-zueoyesj	1156	28	melanoma	melanoma	NN
cord-000248-zueoyesj	1156	29	growth	growth	NN
cord-000248-zueoyesj	1156	30	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1156	31	activity	activity	NN
cord-000248-zueoyesj	1156	32	(	(	-LRB-
cord-000248-zueoyesj	1156	33	MGSA	MGSA	NNP
cord-000248-zueoyesj	1156	34	)	)	-RRB-
cord-000248-zueoyesj	1156	35	in	in	IN
cord-000248-zueoyesj	1156	36	the	the	DT
cord-000248-zueoyesj	1156	37	growth	growth	NN
cord-000248-zueoyesj	1156	38	of	of	IN
cord-000248-zueoyesj	1156	39	normal	normal	JJ
cord-000248-zueoyesj	1156	40	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1156	41	,	,	,
cord-000248-zueoyesj	1156	42	nevocytes	nevocyte	NNS
cord-000248-zueoyesj	1156	43	,	,	,
cord-000248-zueoyesj	1156	44	and	and	CC
cord-000248-zueoyesj	1156	45	malignant	malignant	JJ
cord-000248-zueoyesj	1156	46	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1157	1	Enhanced	enhanced	JJ
cord-000248-zueoyesj	1157	2	tumor	tumor	NN
cord-000248-zueoyesj	1157	3	-	-	HYPH
cord-000248-zueoyesj	1157	4	forming	form	VBG
cord-000248-zueoyesj	1157	5	capacity	capacity	NN
cord-000248-zueoyesj	1157	6	for	for	IN
cord-000248-zueoyesj	1157	7	immortalized	immortalize	VBN
cord-000248-zueoyesj	1157	8	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1157	9	expressing	express	VBG
cord-000248-zueoyesj	1157	10	melanoma	melanoma	NN
cord-000248-zueoyesj	1157	11	growth	growth	NN
cord-000248-zueoyesj	1157	12	stimulatory	stimulatory	JJ
cord-000248-zueoyesj	1157	13	activity	activity	NN
cord-000248-zueoyesj	1157	14	/	/	SYM
cord-000248-zueoyesj	1157	15	growth	growth	NN
cord-000248-zueoyesj	1157	16	-	-	HYPH
cord-000248-zueoyesj	1157	17	regulated	regulate	VBN
cord-000248-zueoyesj	1157	18	cytokine	cytokine	NN
cord-000248-zueoyesj	1157	19	beta	beta	NN
cord-000248-zueoyesj	1157	20	and	and	CC
cord-000248-zueoyesj	1157	21	gamma	gamma	NN
cord-000248-zueoyesj	1157	22	proteins	protein	NNS
cord-000248-zueoyesj	1157	23	Expression	expression	NN
cord-000248-zueoyesj	1157	24	and	and	CC
cord-000248-zueoyesj	1157	25	migratory	migratory	JJ
cord-000248-zueoyesj	1157	26	analysis	analysis	NN
cord-000248-zueoyesj	1157	27	of	of	IN
cord-000248-zueoyesj	1157	28	5	5	CD
cord-000248-zueoyesj	1157	29	human	human	JJ
cord-000248-zueoyesj	1157	30	uveal	uveal	JJ
cord-000248-zueoyesj	1157	31	melanoma	melanoma	NN
cord-000248-zueoyesj	1157	32	cell	cell	NN
cord-000248-zueoyesj	1157	33	lines	line	NNS
cord-000248-zueoyesj	1157	34	for	for	IN
cord-000248-zueoyesj	1157	35	CXCL12	CXCL12	NNP
cord-000248-zueoyesj	1157	36	,	,	,
cord-000248-zueoyesj	1157	37	CXCL8	CXCL8	NNP
cord-000248-zueoyesj	1157	38	,	,	,
cord-000248-zueoyesj	1157	39	CXCL1	CXCL1	NNP
cord-000248-zueoyesj	1157	40	,	,	,
cord-000248-zueoyesj	1157	41	and	and	CC
cord-000248-zueoyesj	1157	42	HGF	HGF	NNP
cord-000248-zueoyesj	1157	43	Inhibition	Inhibition	NNP
cord-000248-zueoyesj	1157	44	of	of	IN
cord-000248-zueoyesj	1157	45	multiple	multiple	JJ
cord-000248-zueoyesj	1157	46	vascular	vascular	JJ
cord-000248-zueoyesj	1157	47	endothelial	endothelial	JJ
cord-000248-zueoyesj	1157	48	growth	growth	NN
cord-000248-zueoyesj	1157	49	factor	factor	NN
cord-000248-zueoyesj	1157	50	receptors	receptor	NNS
cord-000248-zueoyesj	1157	51	(	(	-LRB-
cord-000248-zueoyesj	1157	52	VEGFR	VEGFR	NNP
cord-000248-zueoyesj	1157	53	)	)	-RRB-
cord-000248-zueoyesj	1158	1	blocks	block	NNS
cord-000248-zueoyesj	1159	1	lymph	lymph	NNP
cord-000248-zueoyesj	1159	2	node	node	NN
cord-000248-zueoyesj	1160	1	metastases	metastasis	NNS
cord-000248-zueoyesj	1160	2	but	but	CC
cord-000248-zueoyesj	1161	1	inhibition	inhibition	NN
cord-000248-zueoyesj	1161	2	of	of	IN
cord-000248-zueoyesj	1161	3	VEGFR-2	VEGFR-2	NNP
cord-000248-zueoyesj	1161	4	is	be	VBZ
cord-000248-zueoyesj	1161	5	sufficient	sufficient	JJ
cord-000248-zueoyesj	1161	6	to	to	TO
cord-000248-zueoyesj	1161	7	sensitize	sensitize	VB
cord-000248-zueoyesj	1161	8	tumor	tumor	NN
cord-000248-zueoyesj	1161	9	cells	cell	NNS
cord-000248-zueoyesj	1161	10	to	to	IN
cord-000248-zueoyesj	1161	11	platinum	platinum	NN
cord-000248-zueoyesj	1161	12	-	-	HYPH
cord-000248-zueoyesj	1161	13	based	base	VBN
cord-000248-zueoyesj	1161	14	chemotherapeutics	chemotherapeutic	NNS
cord-000248-zueoyesj	1161	15	Pilot	Pilot	NNP
cord-000248-zueoyesj	1161	16	study	study	NN
cord-000248-zueoyesj	1161	17	on	on	IN
cord-000248-zueoyesj	1161	18	the	the	DT
cord-000248-zueoyesj	1161	19	interaction	interaction	NN
cord-000248-zueoyesj	1161	20	between	between	IN
cord-000248-zueoyesj	1161	21	B16	B16	NNP
cord-000248-zueoyesj	1161	22	melanoma	melanoma	NN
cord-000248-zueoyesj	1161	23	cell	cell	NN
cord-000248-zueoyesj	1161	24	-	-	HYPH
cord-000248-zueoyesj	1161	25	line	line	NN
cord-000248-zueoyesj	1161	26	and	and	CC
cord-000248-zueoyesj	1161	27	bone	bone	NN
cord-000248-zueoyesj	1161	28	-	-	HYPH
cord-000248-zueoyesj	1161	29	marrow	marrow	NN
cord-000248-zueoyesj	1161	30	derived	derive	VBN
cord-000248-zueoyesj	1161	31	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	1161	32	stem	stem	NN
cord-000248-zueoyesj	1161	33	cells	cell	NNS
cord-000248-zueoyesj	1162	1	Circulating	circulate	VBG
cord-000248-zueoyesj	1162	2	serum	serum	NN
cord-000248-zueoyesj	1162	3	levels	level	NNS
cord-000248-zueoyesj	1162	4	of	of	IN
cord-000248-zueoyesj	1162	5	angiogenic	angiogenic	JJ
cord-000248-zueoyesj	1162	6	factors	factor	NNS
cord-000248-zueoyesj	1162	7	and	and	CC
cord-000248-zueoyesj	1162	8	vascular	vascular	JJ
cord-000248-zueoyesj	1162	9	endothelial	endothelial	JJ
cord-000248-zueoyesj	1162	10	growth	growth	NN
cord-000248-zueoyesj	1162	11	factor	factor	NN
cord-000248-zueoyesj	1162	12	receptors	receptor	NNS
cord-000248-zueoyesj	1162	13	1	1	CD
cord-000248-zueoyesj	1162	14	and	and	CC
cord-000248-zueoyesj	1162	15	2	2	CD
cord-000248-zueoyesj	1162	16	in	in	IN
cord-000248-zueoyesj	1162	17	melanoma	melanoma	NN
cord-000248-zueoyesj	1162	18	patients	patient	NNS
cord-000248-zueoyesj	1162	19	Analysis	Analysis	NNP
cord-000248-zueoyesj	1162	20	of	of	IN
cord-000248-zueoyesj	1162	21	the	the	DT
cord-000248-zueoyesj	1162	22	tyrosine	tyrosine	NN
cord-000248-zueoyesj	1162	23	kinome	kinome	FW
cord-000248-zueoyesj	1162	24	in	in	IN
cord-000248-zueoyesj	1162	25	melanoma	melanoma	NN
cord-000248-zueoyesj	1162	26	reveals	reveal	VBZ
cord-000248-zueoyesj	1162	27	recurrent	recurrent	JJ
cord-000248-zueoyesj	1162	28	mutations	mutation	NNS
cord-000248-zueoyesj	1162	29	in	in	IN
cord-000248-zueoyesj	1162	30	ERBB4	erbb4	NN
cord-000248-zueoyesj	1163	1	The	the	DT
cord-000248-zueoyesj	1163	2	role	role	NN
cord-000248-zueoyesj	1163	3	of	of	IN
cord-000248-zueoyesj	1163	4	vascular	vascular	JJ
cord-000248-zueoyesj	1163	5	endothelial	endothelial	JJ
cord-000248-zueoyesj	1163	6	growth	growth	NN
cord-000248-zueoyesj	1163	7	factors	factor	NNS
cord-000248-zueoyesj	1163	8	and	and	CC
cord-000248-zueoyesj	1163	9	their	-PRON-	PRP$
cord-000248-zueoyesj	1163	10	receptors	receptor	NNS
cord-000248-zueoyesj	1163	11	in	in	IN
cord-000248-zueoyesj	1163	12	malignant	malignant	JJ
cord-000248-zueoyesj	1163	13	melanomas	melanoma	NNS
cord-000248-zueoyesj	1164	1	The	the	DT
cord-000248-zueoyesj	1164	2	role	role	NN
cord-000248-zueoyesj	1164	3	of	of	IN
cord-000248-zueoyesj	1164	4	circulating	circulate	VBG
cord-000248-zueoyesj	1164	5	angiogenic	angiogenic	JJ
cord-000248-zueoyesj	1164	6	factors	factor	NNS
cord-000248-zueoyesj	1164	7	in	in	IN
cord-000248-zueoyesj	1164	8	patients	patient	NNS
cord-000248-zueoyesj	1164	9	operated	operate	VBN
cord-000248-zueoyesj	1164	10	on	on	IN
cord-000248-zueoyesj	1164	11	for	for	IN
cord-000248-zueoyesj	1164	12	localized	localized	JJ
cord-000248-zueoyesj	1164	13	malignant	malignant	JJ
cord-000248-zueoyesj	1164	14	melanoma	melanoma	NN
cord-000248-zueoyesj	1164	15	Simultaneous	simultaneous	JJ
cord-000248-zueoyesj	1164	16	blockade	blockade	NN
cord-000248-zueoyesj	1164	17	of	of	IN
cord-000248-zueoyesj	1164	18	VEGFR-1	vegfr-1	NN
cord-000248-zueoyesj	1164	19	and	and	CC
cord-000248-zueoyesj	1164	20	VEGFR-2	vegfr-2	NN
cord-000248-zueoyesj	1164	21	activation	activation	NN
cord-000248-zueoyesj	1164	22	is	be	VBZ
cord-000248-zueoyesj	1164	23	necessary	necessary	JJ
cord-000248-zueoyesj	1164	24	to	to	TO
cord-000248-zueoyesj	1164	25	efficiently	efficiently	RB
cord-000248-zueoyesj	1164	26	inhibit	inhibit	VB
cord-000248-zueoyesj	1164	27	experimental	experimental	JJ
cord-000248-zueoyesj	1164	28	melanoma	melanoma	NN
cord-000248-zueoyesj	1164	29	growth	growth	NN
cord-000248-zueoyesj	1164	30	and	and	CC
cord-000248-zueoyesj	1164	31	metastasis	metastasis	NN
cord-000248-zueoyesj	1164	32	formation	formation	NN
cord-000248-zueoyesj	1164	33	Flt-1	Flt-1	NNP
cord-000248-zueoyesj	1165	1	intraceptor	intraceptor	NNP
cord-000248-zueoyesj	1165	2	induces	induce	VBZ
cord-000248-zueoyesj	1165	3	the	the	DT
cord-000248-zueoyesj	1165	4	unfolded	unfolded	JJ
cord-000248-zueoyesj	1165	5	protein	protein	NN
cord-000248-zueoyesj	1165	6	response	response	NN
cord-000248-zueoyesj	1165	7	,	,	,
cord-000248-zueoyesj	1165	8	apoptotic	apoptotic	JJ
cord-000248-zueoyesj	1165	9	factors	factor	NNS
cord-000248-zueoyesj	1165	10	,	,	,
cord-000248-zueoyesj	1165	11	and	and	CC
cord-000248-zueoyesj	1165	12	regression	regression	NN
cord-000248-zueoyesj	1165	13	of	of	IN
cord-000248-zueoyesj	1165	14	murine	murine	JJ
cord-000248-zueoyesj	1165	15	injury	injury	NN
cord-000248-zueoyesj	1165	16	-	-	HYPH
cord-000248-zueoyesj	1165	17	induced	induce	VBN
cord-000248-zueoyesj	1165	18	corneal	corneal	JJ
cord-000248-zueoyesj	1165	19	neovascularization	neovascularization	NN
cord-000248-zueoyesj	1166	1	An	an	DT
cord-000248-zueoyesj	1166	2	autocrine	autocrine	JJ
cord-000248-zueoyesj	1166	3	loop	loop	NN
cord-000248-zueoyesj	1166	4	directed	direct	VBN
cord-000248-zueoyesj	1166	5	by	by	IN
cord-000248-zueoyesj	1166	6	the	the	DT
cord-000248-zueoyesj	1166	7	vascular	vascular	JJ
cord-000248-zueoyesj	1166	8	endothelial	endothelial	JJ
cord-000248-zueoyesj	1166	9	growth	growth	NN
cord-000248-zueoyesj	1166	10	factor	factor	NN
cord-000248-zueoyesj	1166	11	promotes	promote	VBZ
cord-000248-zueoyesj	1166	12	invasiveness	invasiveness	NN
cord-000248-zueoyesj	1166	13	of	of	IN
cord-000248-zueoyesj	1166	14	human	human	JJ
cord-000248-zueoyesj	1166	15	melanoma	melanoma	NN
cord-000248-zueoyesj	1166	16	cells	cell	NNS
cord-000248-zueoyesj	1167	1	Overproduction	overproduction	NN
cord-000248-zueoyesj	1167	2	of	of	IN
cord-000248-zueoyesj	1167	3	VEGF	VEGF	NNP
cord-000248-zueoyesj	1167	4	concomitantly	concomitantly	RB
cord-000248-zueoyesj	1167	5	expressed	express	VBD
cord-000248-zueoyesj	1167	6	with	with	IN
cord-000248-zueoyesj	1167	7	its	-PRON-	PRP$
cord-000248-zueoyesj	1167	8	receptors	receptor	NNS
cord-000248-zueoyesj	1167	9	promotes	promote	VBZ
cord-000248-zueoyesj	1167	10	growth	growth	NN
cord-000248-zueoyesj	1167	11	and	and	CC
cord-000248-zueoyesj	1167	12	survival	survival	NN
cord-000248-zueoyesj	1167	13	of	of	IN
cord-000248-zueoyesj	1167	14	melanoma	melanoma	NN
cord-000248-zueoyesj	1167	15	cells	cell	NNS
cord-000248-zueoyesj	1167	16	through	through	IN
cord-000248-zueoyesj	1167	17	MAPK	MAPK	NNP
cord-000248-zueoyesj	1167	18	and	and	CC
cord-000248-zueoyesj	1167	19	PI3	PI3	NNP
cord-000248-zueoyesj	1167	20	K	K	NNP
cord-000248-zueoyesj	1167	21	signaling	signal	VBG
cord-000248-zueoyesj	1167	22	MMP9	MMP9	NNP
cord-000248-zueoyesj	1167	23	induction	induction	NN
cord-000248-zueoyesj	1167	24	by	by	IN
cord-000248-zueoyesj	1167	25	vascular	vascular	JJ
cord-000248-zueoyesj	1167	26	endothelial	endothelial	JJ
cord-000248-zueoyesj	1167	27	growth	growth	NN
cord-000248-zueoyesj	1167	28	factor	factor	NN
cord-000248-zueoyesj	1168	1	receptor-1	receptor-1	NNP
cord-000248-zueoyesj	1168	2	is	be	VBZ
cord-000248-zueoyesj	1168	3	involved	involve	VBN
cord-000248-zueoyesj	1168	4	in	in	IN
cord-000248-zueoyesj	1168	5	lungspecific	lungspecific	JJ
cord-000248-zueoyesj	1168	6	metastasis	metastasis	NN
cord-000248-zueoyesj	1168	7	Release	release	NN
cord-000248-zueoyesj	1168	8	and	and	CC
cord-000248-zueoyesj	1168	9	complex	complex	JJ
cord-000248-zueoyesj	1168	10	formation	formation	NN
cord-000248-zueoyesj	1168	11	of	of	IN
cord-000248-zueoyesj	1168	12	soluble	soluble	JJ
cord-000248-zueoyesj	1168	13	VEGFR-1	VEGFR-1	NNS
cord-000248-zueoyesj	1168	14	from	from	IN
cord-000248-zueoyesj	1168	15	endothelial	endothelial	JJ
cord-000248-zueoyesj	1168	16	cells	cell	NNS
cord-000248-zueoyesj	1168	17	and	and	CC
cord-000248-zueoyesj	1168	18	biological	biological	JJ
cord-000248-zueoyesj	1168	19	fluids	fluid	NNS
cord-000248-zueoyesj	1169	1	Angiogenesis	angiogenesis	NN
cord-000248-zueoyesj	1169	2	and	and	CC
cord-000248-zueoyesj	1169	3	vascular	vascular	JJ
cord-000248-zueoyesj	1169	4	growth	growth	NN
cord-000248-zueoyesj	1169	5	factor	factor	NN
cord-000248-zueoyesj	1169	6	receptor	receptor	NN
cord-000248-zueoyesj	1169	7	expression	expression	NN
cord-000248-zueoyesj	1169	8	in	in	IN
cord-000248-zueoyesj	1169	9	malignant	malignant	JJ
cord-000248-zueoyesj	1169	10	melanoma	melanoma	NN
cord-000248-zueoyesj	1169	11	Association	Association	NNP
cord-000248-zueoyesj	1169	12	of	of	IN
cord-000248-zueoyesj	1169	13	increased	increase	VBN
cord-000248-zueoyesj	1169	14	levels	level	NNS
cord-000248-zueoyesj	1169	15	of	of	IN
cord-000248-zueoyesj	1169	16	heavychain	heavychain	NN
cord-000248-zueoyesj	1169	17	ferritin	ferritin	NN
cord-000248-zueoyesj	1169	18	with	with	IN
cord-000248-zueoyesj	1169	19	increased	increase	VBN
cord-000248-zueoyesj	1169	20	CD4	CD4	NNP
cord-000248-zueoyesj	1169	21	+	+	CC
cord-000248-zueoyesj	1169	22	CD25	CD25	NNP
cord-000248-zueoyesj	1169	23	+	+	CC
cord-000248-zueoyesj	1169	24	regulatory	regulatory	JJ
cord-000248-zueoyesj	1169	25	T	t	NN
cord-000248-zueoyesj	1169	26	-	-	HYPH
cord-000248-zueoyesj	1169	27	cell	cell	NN
cord-000248-zueoyesj	1169	28	levels	level	NNS
cord-000248-zueoyesj	1169	29	in	in	IN
cord-000248-zueoyesj	1169	30	patients	patient	NNS
cord-000248-zueoyesj	1169	31	with	with	IN
cord-000248-zueoyesj	1170	1	melanoma	melanoma	NN
cord-000248-zueoyesj	1170	2	Heavy	Heavy	NNP
cord-000248-zueoyesj	1170	3	chain	chain	NN
cord-000248-zueoyesj	1170	4	ferritin	ferritin	NN
cord-000248-zueoyesj	1170	5	activates	activate	VBZ
cord-000248-zueoyesj	1170	6	regulatory	regulatory	JJ
cord-000248-zueoyesj	1170	7	T	t	NN
cord-000248-zueoyesj	1170	8	cells	cell	NNS
cord-000248-zueoyesj	1170	9	by	by	IN
cord-000248-zueoyesj	1170	10	induction	induction	NN
cord-000248-zueoyesj	1170	11	of	of	IN
cord-000248-zueoyesj	1170	12	changes	change	NNS
cord-000248-zueoyesj	1170	13	in	in	IN
cord-000248-zueoyesj	1170	14	dendritic	dendritic	JJ
cord-000248-zueoyesj	1170	15	cells	cell	NNS
cord-000248-zueoyesj	1170	16	Immunosuppressive	immunosuppressive	JJ
cord-000248-zueoyesj	1170	17	effects	effect	NNS
cord-000248-zueoyesj	1170	18	of	of	IN
cord-000248-zueoyesj	1170	19	melanoma	melanoma	NN
cord-000248-zueoyesj	1170	20	-	-	HYPH
cord-000248-zueoyesj	1170	21	derived	derive	VBN
cord-000248-zueoyesj	1170	22	heavy	heavy	JJ
cord-000248-zueoyesj	1170	23	-	-	HYPH
cord-000248-zueoyesj	1170	24	chain	chain	NN
cord-000248-zueoyesj	1170	25	ferritin	ferritin	NN
cord-000248-zueoyesj	1170	26	are	be	VBP
cord-000248-zueoyesj	1170	27	dependent	dependent	JJ
cord-000248-zueoyesj	1170	28	on	on	IN
cord-000248-zueoyesj	1170	29	stimulation	stimulation	NN
cord-000248-zueoyesj	1170	30	of	of	IN
cord-000248-zueoyesj	1170	31	IL-10	IL-10	NNP
cord-000248-zueoyesj	1170	32	production	production	NN
cord-000248-zueoyesj	1170	33	Ferritin	ferritin	NN
cord-000248-zueoyesj	1170	34	heavy	heavy	JJ
cord-000248-zueoyesj	1170	35	chain	chain	NN
cord-000248-zueoyesj	1170	36	upregulation	upregulation	NN
cord-000248-zueoyesj	1170	37	by	by	IN
cord-000248-zueoyesj	1170	38	NF	NF	NNP
cord-000248-zueoyesj	1170	39	-	-	HYPH
cord-000248-zueoyesj	1170	40	kappaB	kappaB	NNP
cord-000248-zueoyesj	1170	41	inhibits	inhibit	VBZ
cord-000248-zueoyesj	1170	42	TNFalpha	tnfalpha	NN
cord-000248-zueoyesj	1170	43	-	-	HYPH
cord-000248-zueoyesj	1170	44	induced	induce	VBN
cord-000248-zueoyesj	1170	45	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1170	46	by	by	IN
cord-000248-zueoyesj	1170	47	suppressing	suppress	VBG
cord-000248-zueoyesj	1170	48	reactive	reactive	JJ
cord-000248-zueoyesj	1170	49	oxygen	oxygen	NN
cord-000248-zueoyesj	1170	50	species	specie	NNS
cord-000248-zueoyesj	1170	51	Sealing	sealing	NN
cord-000248-zueoyesj	1170	52	of	of	IN
cord-000248-zueoyesj	1170	53	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1170	54	DNA	dna	NN
cord-000248-zueoyesj	1170	55	nicks	nick	NNS
cord-000248-zueoyesj	1170	56	during	during	IN
cord-000248-zueoyesj	1170	57	nucleotide	nucleotide	JJ
cord-000248-zueoyesj	1170	58	excision	excision	NN
cord-000248-zueoyesj	1170	59	repair	repair	NN
cord-000248-zueoyesj	1170	60	requires	require	VBZ
cord-000248-zueoyesj	1170	61	XRCC1	XRCC1	NNS
cord-000248-zueoyesj	1170	62	and	and	CC
cord-000248-zueoyesj	1170	63	DNA	dna	NN
cord-000248-zueoyesj	1170	64	ligase	ligase	NN
cord-000248-zueoyesj	1170	65	III	iii	CD
cord-000248-zueoyesj	1170	66	alpha	alpha	NN
cord-000248-zueoyesj	1170	67	in	in	IN
cord-000248-zueoyesj	1170	68	a	a	DT
cord-000248-zueoyesj	1170	69	cell	cell	NN
cord-000248-zueoyesj	1170	70	-	-	HYPH
cord-000248-zueoyesj	1170	71	cycle	cycle	NN
cord-000248-zueoyesj	1170	72	-	-	HYPH
cord-000248-zueoyesj	1170	73	specific	specific	JJ
cord-000248-zueoyesj	1170	74	manner	manner	JJ
cord-000248-zueoyesj	1170	75	Gene	gene	NN
cord-000248-zueoyesj	1170	76	expression	expression	NN
cord-000248-zueoyesj	1170	77	profiles	profile	NNS
cord-000248-zueoyesj	1170	78	in	in	IN
cord-000248-zueoyesj	1170	79	radiation	radiation	NN
cord-000248-zueoyesj	1170	80	workers	worker	NNS
cord-000248-zueoyesj	1170	81	occupationally	occupationally	RB
cord-000248-zueoyesj	1170	82	exposed	expose	VBN
cord-000248-zueoyesj	1170	83	to	to	IN
cord-000248-zueoyesj	1170	84	ionizing	ionize	VBG
cord-000248-zueoyesj	1170	85	radiation	radiation	NN
cord-000248-zueoyesj	1170	86	Human	human	JJ
cord-000248-zueoyesj	1170	87	melanoma	melanoma	NN
cord-000248-zueoyesj	1170	88	cells	cell	NNS
cord-000248-zueoyesj	1170	89	secrete	secrete	VBP
cord-000248-zueoyesj	1170	90	and	and	CC
cord-000248-zueoyesj	1170	91	respond	respond	VBP
cord-000248-zueoyesj	1170	92	to	to	IN
cord-000248-zueoyesj	1170	93	placenta	placenta	NN
cord-000248-zueoyesj	1170	94	growth	growth	NN
cord-000248-zueoyesj	1170	95	factor	factor	NN
cord-000248-zueoyesj	1170	96	and	and	CC
cord-000248-zueoyesj	1170	97	vascular	vascular	JJ
cord-000248-zueoyesj	1170	98	endothelial	endothelial	JJ
cord-000248-zueoyesj	1170	99	growth	growth	NN
cord-000248-zueoyesj	1170	100	factor	factor	NN
cord-000248-zueoyesj	1170	101	Expression	expression	NN
cord-000248-zueoyesj	1170	102	patterns	pattern	NNS
cord-000248-zueoyesj	1170	103	of	of	IN
cord-000248-zueoyesj	1170	104	placenta	placenta	NN
cord-000248-zueoyesj	1170	105	growth	growth	NN
cord-000248-zueoyesj	1170	106	factor	factor	NN
cord-000248-zueoyesj	1170	107	in	in	IN
cord-000248-zueoyesj	1171	1	human	human	JJ
cord-000248-zueoyesj	1171	2	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	1171	3	cell	cell	NN
cord-000248-zueoyesj	1171	4	lines	line	NNS
cord-000248-zueoyesj	1171	5	Neuropilins	Neuropilins	NNP
cord-000248-zueoyesj	1171	6	in	in	IN
cord-000248-zueoyesj	1171	7	tumor	tumor	NN
cord-000248-zueoyesj	1171	8	biology	biology	NN
cord-000248-zueoyesj	1171	9	Semaphorin	Semaphorin	NNP
cord-000248-zueoyesj	1171	10	signaling	signal	VBG
cord-000248-zueoyesj	1171	11	in	in	IN
cord-000248-zueoyesj	1171	12	cancer	cancer	NN
cord-000248-zueoyesj	1171	13	cells	cell	NNS
cord-000248-zueoyesj	1171	14	and	and	CC
cord-000248-zueoyesj	1171	15	in	in	IN
cord-000248-zueoyesj	1171	16	cells	cell	NNS
cord-000248-zueoyesj	1171	17	of	of	IN
cord-000248-zueoyesj	1171	18	the	the	DT
cord-000248-zueoyesj	1171	19	tumor	tumor	NN
cord-000248-zueoyesj	1171	20	microenvironment	microenvironment	NN
cord-000248-zueoyesj	1171	21	-	-	HYPH
cord-000248-zueoyesj	1171	22	two	two	CD
cord-000248-zueoyesj	1171	23	sides	side	NNS
cord-000248-zueoyesj	1171	24	of	of	IN
cord-000248-zueoyesj	1171	25	a	a	DT
cord-000248-zueoyesj	1171	26	coin	coin	NN
cord-000248-zueoyesj	1171	27	From	from	IN
cord-000248-zueoyesj	1171	28	plasma	plasma	NN
cord-000248-zueoyesj	1171	29	membrane	membrane	NN
cord-000248-zueoyesj	1171	30	to	to	IN
cord-000248-zueoyesj	1171	31	cytoskeleton	cytoskeleton	NN
cord-000248-zueoyesj	1171	32	:	:	:
cord-000248-zueoyesj	1171	33	a	a	DT
cord-000248-zueoyesj	1171	34	novel	novel	JJ
cord-000248-zueoyesj	1171	35	function	function	NN
cord-000248-zueoyesj	1171	36	for	for	IN
cord-000248-zueoyesj	1171	37	semaphorin	semaphorin	NNP
cord-000248-zueoyesj	1171	38	6A	6A	NNP
cord-000248-zueoyesj	1171	39	Semaphorins	Semaphorins	NNP
cord-000248-zueoyesj	1171	40	at	at	IN
cord-000248-zueoyesj	1171	41	the	the	DT
cord-000248-zueoyesj	1171	42	interface	interface	NN
cord-000248-zueoyesj	1171	43	of	of	IN
cord-000248-zueoyesj	1171	44	development	development	NN
cord-000248-zueoyesj	1171	45	and	and	CC
cord-000248-zueoyesj	1171	46	cancer	cancer	NN
cord-000248-zueoyesj	1171	47	Comparative	Comparative	NNP
cord-000248-zueoyesj	1171	48	integromics	integromic	NNS
cord-000248-zueoyesj	1171	49	on	on	IN
cord-000248-zueoyesj	1171	50	non	non	JJ
cord-000248-zueoyesj	1171	51	-	-	JJ
cord-000248-zueoyesj	1171	52	canonical	canonical	JJ
cord-000248-zueoyesj	1171	53	WNT	wnt	NN
cord-000248-zueoyesj	1171	54	or	or	CC
cord-000248-zueoyesj	1171	55	planar	planar	JJ
cord-000248-zueoyesj	1171	56	cell	cell	NN
cord-000248-zueoyesj	1171	57	polarity	polarity	NN
cord-000248-zueoyesj	1171	58	signaling	signal	VBG
cord-000248-zueoyesj	1171	59	molecules	molecule	NNS
cord-000248-zueoyesj	1171	60	:	:	:
cord-000248-zueoyesj	1171	61	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1171	62	mechanism	mechanism	NN
cord-000248-zueoyesj	1171	63	of	of	IN
cord-000248-zueoyesj	1171	64	PTK7	PTK7	NNP
cord-000248-zueoyesj	1171	65	in	in	IN
cord-000248-zueoyesj	1171	66	colorectal	colorectal	JJ
cord-000248-zueoyesj	1171	67	cancer	cancer	NN
cord-000248-zueoyesj	1171	68	and	and	CC
cord-000248-zueoyesj	1171	69	that	that	DT
cord-000248-zueoyesj	1171	70	of	of	IN
cord-000248-zueoyesj	1171	71	SEMA6A	SEMA6A	NNP
cord-000248-zueoyesj	1171	72	in	in	IN
cord-000248-zueoyesj	1171	73	undifferentiated	undifferentiated	JJ
cord-000248-zueoyesj	1171	74	ES	es	NN
cord-000248-zueoyesj	1171	75	cells	cell	NNS
cord-000248-zueoyesj	1171	76	Deciphering	decipher	VBG
cord-000248-zueoyesj	1171	77	developmental	developmental	JJ
cord-000248-zueoyesj	1171	78	stages	stage	NNS
cord-000248-zueoyesj	1171	79	of	of	IN
cord-000248-zueoyesj	1171	80	adult	adult	NN
cord-000248-zueoyesj	1171	81	myelopoiesis	myelopoiesis	NNP
cord-000248-zueoyesj	1171	82	Downregulation	Downregulation	NNP
cord-000248-zueoyesj	1171	83	of	of	IN
cord-000248-zueoyesj	1171	84	CCN3	CCN3	NNP
cord-000248-zueoyesj	1171	85	expression	expression	NN
cord-000248-zueoyesj	1171	86	as	as	IN
cord-000248-zueoyesj	1171	87	a	a	DT
cord-000248-zueoyesj	1171	88	potential	potential	JJ
cord-000248-zueoyesj	1171	89	mechanism	mechanism	NN
cord-000248-zueoyesj	1171	90	for	for	IN
cord-000248-zueoyesj	1171	91	melanoma	melanoma	NN
cord-000248-zueoyesj	1171	92	progression	progression	NN
cord-000248-zueoyesj	1172	1	Osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1172	2	expression	expression	NN
cord-000248-zueoyesj	1172	3	in	in	IN
cord-000248-zueoyesj	1172	4	normal	normal	JJ
cord-000248-zueoyesj	1172	5	skin	skin	NN
cord-000248-zueoyesj	1172	6	and	and	CC
cord-000248-zueoyesj	1172	7	non	non	JJ
cord-000248-zueoyesj	1172	8	-	-	JJ
cord-000248-zueoyesj	1172	9	melanoma	melanoma	JJ
cord-000248-zueoyesj	1172	10	skin	skin	NN
cord-000248-zueoyesj	1172	11	tumors	tumor	NNS
cord-000248-zueoyesj	1173	1	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1173	2	stimulates	stimulate	VBZ
cord-000248-zueoyesj	1173	3	melanoma	melanoma	NN
cord-000248-zueoyesj	1173	4	growth	growth	NN
cord-000248-zueoyesj	1173	5	and	and	CC
cord-000248-zueoyesj	1173	6	lung	lung	NN
cord-000248-zueoyesj	1173	7	metastasis	metastasis	NN
cord-000248-zueoyesj	1173	8	through	through	IN
cord-000248-zueoyesj	1173	9	NIK	NIK	NNP
cord-000248-zueoyesj	1173	10	/	/	SYM
cord-000248-zueoyesj	1173	11	MEKK1-dependent	MEKK1-dependent	NNP
cord-000248-zueoyesj	1173	12	MMP-9	MMP-9	NNP
cord-000248-zueoyesj	1173	13	activation	activation	NN
cord-000248-zueoyesj	1173	14	pathways	pathway	NNS
cord-000248-zueoyesj	1173	15	Osteonectin	Osteonectin	NNP
cord-000248-zueoyesj	1173	16	downregulates	downregulate	VBZ
cord-000248-zueoyesj	1173	17	Ecadherin	Ecadherin	NNP
cord-000248-zueoyesj	1173	18	,	,	,
cord-000248-zueoyesj	1173	19	induces	induce	VBZ
cord-000248-zueoyesj	1173	20	osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1173	21	and	and	CC
cord-000248-zueoyesj	1173	22	focal	focal	JJ
cord-000248-zueoyesj	1173	23	adhesion	adhesion	NN
cord-000248-zueoyesj	1173	24	kinase	kinase	NN
cord-000248-zueoyesj	1173	25	activity	activity	NN
cord-000248-zueoyesj	1173	26	stimulating	stimulate	VBG
cord-000248-zueoyesj	1173	27	an	an	DT
cord-000248-zueoyesj	1173	28	invasive	invasive	JJ
cord-000248-zueoyesj	1173	29	melanoma	melanoma	NN
cord-000248-zueoyesj	1173	30	phenotype	phenotype	NN
cord-000248-zueoyesj	1173	31	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1173	32	expression	expression	NN
cord-000248-zueoyesj	1173	33	in	in	IN
cord-000248-zueoyesj	1173	34	Spitz	Spitz	NNP
cord-000248-zueoyesj	1173	35	nevi	nevus	NNS
cord-000248-zueoyesj	1173	36	Serum	serum	NN
cord-000248-zueoyesj	1173	37	markers	marker	NNS
cord-000248-zueoyesj	1173	38	to	to	TO
cord-000248-zueoyesj	1173	39	detect	detect	VB
cord-000248-zueoyesj	1173	40	metastatic	metastatic	JJ
cord-000248-zueoyesj	1173	41	uveal	uveal	JJ
cord-000248-zueoyesj	1173	42	melanoma	melanoma	NN
cord-000248-zueoyesj	1173	43	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1173	44	and	and	CC
cord-000248-zueoyesj	1173	45	the	the	DT
cord-000248-zueoyesj	1173	46	skin	skin	NN
cord-000248-zueoyesj	1173	47	:	:	:
cord-000248-zueoyesj	1173	48	multiple	multiple	JJ
cord-000248-zueoyesj	1173	49	emerging	emerge	VBG
cord-000248-zueoyesj	1173	50	roles	role	NNS
cord-000248-zueoyesj	1173	51	in	in	IN
cord-000248-zueoyesj	1173	52	cutaneous	cutaneous	JJ
cord-000248-zueoyesj	1173	53	biology	biology	NN
cord-000248-zueoyesj	1173	54	and	and	CC
cord-000248-zueoyesj	1173	55	pathology	pathology	NN
cord-000248-zueoyesj	1174	1	The	the	DT
cord-000248-zueoyesj	1174	2	Hedgehog	Hedgehog	NNP
cord-000248-zueoyesj	1174	3	Pathway	Pathway	NNP
cord-000248-zueoyesj	1174	4	Transcription	Transcription	NNP
cord-000248-zueoyesj	1174	5	Factor	Factor	NNP
cord-000248-zueoyesj	1174	6	GLI1	GLI1	NNP
cord-000248-zueoyesj	1174	7	Promotes	promote	VBZ
cord-000248-zueoyesj	1174	8	Malignant	malignant	JJ
cord-000248-zueoyesj	1174	9	Behavior	Behavior	NNP
cord-000248-zueoyesj	1174	10	of	of	IN
cord-000248-zueoyesj	1174	11	Cancer	Cancer	NNP
cord-000248-zueoyesj	1174	12	Cells	cell	NNS
cord-000248-zueoyesj	1174	13	by	by	IN
cord-000248-zueoyesj	1174	14	Up	up	IN
cord-000248-zueoyesj	1174	15	-	-	HYPH
cord-000248-zueoyesj	1174	16	regulating	regulate	VBG
cord-000248-zueoyesj	1174	17	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1174	18	Expression	expression	NN
cord-000248-zueoyesj	1174	19	of	of	IN
cord-000248-zueoyesj	1174	20	phosphorylated	phosphorylate	VBN
cord-000248-zueoyesj	1174	21	-	-	HYPH
cord-000248-zueoyesj	1174	22	STAT3	STAT3	NNP
cord-000248-zueoyesj	1174	23	and	and	CC
cord-000248-zueoyesj	1174	24	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1174	25	and	and	CC
cord-000248-zueoyesj	1174	26	their	-PRON-	PRP$
cord-000248-zueoyesj	1174	27	correlation	correlation	NN
cord-000248-zueoyesj	1174	28	in	in	IN
cord-000248-zueoyesj	1174	29	melanoma	melanoma	NN
cord-000248-zueoyesj	1174	30	Matricellular	Matricellular	NNP
cord-000248-zueoyesj	1174	31	proteins	protein	NNS
cord-000248-zueoyesj	1174	32	produced	produce	VBN
cord-000248-zueoyesj	1174	33	by	by	IN
cord-000248-zueoyesj	1174	34	melanocytes	melanocyte	NNS
cord-000248-zueoyesj	1174	35	and	and	CC
cord-000248-zueoyesj	1174	36	melanomas	melanoma	NNS
cord-000248-zueoyesj	1174	37	:	:	:
cord-000248-zueoyesj	1175	1	in	in	IN
cord-000248-zueoyesj	1175	2	search	search	NN
cord-000248-zueoyesj	1175	3	for	for	IN
cord-000248-zueoyesj	1175	4	functions	function	NNS
cord-000248-zueoyesj	1175	5	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1175	6	and	and	CC
cord-000248-zueoyesj	1175	7	'	'	``
cord-000248-zueoyesj	1175	8	melanoma	melanoma	NN
cord-000248-zueoyesj	1175	9	inhibitory	inhibitory	JJ
cord-000248-zueoyesj	1175	10	activity	activity	NN
cord-000248-zueoyesj	1175	11	'	'	''
cord-000248-zueoyesj	1175	12	:	:	:
cord-000248-zueoyesj	1175	13	comparison	comparison	NN
cord-000248-zueoyesj	1175	14	of	of	IN
cord-000248-zueoyesj	1175	15	two	two	CD
cord-000248-zueoyesj	1175	16	serological	serological	JJ
cord-000248-zueoyesj	1175	17	tumor	tumor	NN
cord-000248-zueoyesj	1175	18	markers	marker	NNS
cord-000248-zueoyesj	1175	19	in	in	IN
cord-000248-zueoyesj	1175	20	metastatic	metastatic	JJ
cord-000248-zueoyesj	1175	21	uveal	uveal	JJ
cord-000248-zueoyesj	1175	22	melanoma	melanoma	NN
cord-000248-zueoyesj	1175	23	patients	patient	NNS
cord-000248-zueoyesj	1175	24	Extracellular	Extracellular	NNP
cord-000248-zueoyesj	1175	25	and	and	CC
cord-000248-zueoyesj	1175	26	intracellular	intracellular	JJ
cord-000248-zueoyesj	1175	27	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1175	28	that	that	WDT
cord-000248-zueoyesj	1175	29	mediate	mediate	VBP
cord-000248-zueoyesj	1175	30	the	the	DT
cord-000248-zueoyesj	1175	31	metastatic	metastatic	JJ
cord-000248-zueoyesj	1175	32	activity	activity	NN
cord-000248-zueoyesj	1175	33	of	of	IN
cord-000248-zueoyesj	1175	34	exogenous	exogenous	JJ
cord-000248-zueoyesj	1175	35	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1175	36	Endothelin	Endothelin	NNP
cord-000248-zueoyesj	1175	37	signaling	signaling	NN
cord-000248-zueoyesj	1175	38	axis	axis	NN
cord-000248-zueoyesj	1175	39	activates	activate	VBZ
cord-000248-zueoyesj	1175	40	osteopontin	osteopontin	JJ
cord-000248-zueoyesj	1175	41	expression	expression	NN
cord-000248-zueoyesj	1175	42	through	through	IN
cord-000248-zueoyesj	1175	43	PI3	pi3	NN
cord-000248-zueoyesj	1175	44	kinase	kinase	NN
cord-000248-zueoyesj	1175	45	pathway	pathway	NN
cord-000248-zueoyesj	1175	46	in	in	IN
cord-000248-zueoyesj	1175	47	A375	A375	NNP
cord-000248-zueoyesj	1175	48	melanoma	melanoma	NN
cord-000248-zueoyesj	1175	49	cells	cell	NNS
cord-000248-zueoyesj	1176	1	A	a	DT
cord-000248-zueoyesj	1176	2	highthroughput	highthroughput	NN
cord-000248-zueoyesj	1176	3	study	study	NN
cord-000248-zueoyesj	1176	4	in	in	IN
cord-000248-zueoyesj	1176	5	melanoma	melanoma	NN
cord-000248-zueoyesj	1176	6	identifies	identify	VBZ
cord-000248-zueoyesj	1176	7	epithelial	epithelial	JJ
cord-000248-zueoyesj	1176	8	-	-	HYPH
cord-000248-zueoyesj	1176	9	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	1176	10	transition	transition	NN
cord-000248-zueoyesj	1176	11	as	as	IN
cord-000248-zueoyesj	1176	12	a	a	DT
cord-000248-zueoyesj	1176	13	major	major	JJ
cord-000248-zueoyesj	1176	14	determinant	determinant	NN
cord-000248-zueoyesj	1176	15	of	of	IN
cord-000248-zueoyesj	1176	16	metastasis	metastasis	NN
cord-000248-zueoyesj	1176	17	Serum	serum	NN
cord-000248-zueoyesj	1176	18	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1176	19	,	,	,
cord-000248-zueoyesj	1176	20	an	an	DT
cord-000248-zueoyesj	1176	21	enhancer	enhancer	NN
cord-000248-zueoyesj	1176	22	of	of	IN
cord-000248-zueoyesj	1176	23	tumor	tumor	NN
cord-000248-zueoyesj	1176	24	metastasis	metastasis	NN
cord-000248-zueoyesj	1176	25	to	to	IN
cord-000248-zueoyesj	1176	26	bone	bone	NN
cord-000248-zueoyesj	1176	27	,	,	,
cord-000248-zueoyesj	1176	28	promotes	promote	VBZ
cord-000248-zueoyesj	1176	29	B16	b16	NN
cord-000248-zueoyesj	1176	30	melanoma	melanoma	NN
cord-000248-zueoyesj	1176	31	cell	cell	NN
cord-000248-zueoyesj	1176	32	migration	migration	NN
cord-000248-zueoyesj	1176	33	Gene	gene	NN
cord-000248-zueoyesj	1176	34	-	-	HYPH
cord-000248-zueoyesj	1176	35	specific	specific	JJ
cord-000248-zueoyesj	1176	36	fluorescence	fluorescence	NN
cord-000248-zueoyesj	1176	37	in	in	IN
cord-000248-zueoyesj	1176	38	-	-	HYPH
cord-000248-zueoyesj	1176	39	situ	situ	NN
cord-000248-zueoyesj	1176	40	hybridization	hybridization	NN
cord-000248-zueoyesj	1176	41	analysis	analysis	NN
cord-000248-zueoyesj	1176	42	on	on	IN
cord-000248-zueoyesj	1176	43	tissue	tissue	NN
cord-000248-zueoyesj	1176	44	microarray	microarray	NN
cord-000248-zueoyesj	1176	45	to	to	TO
cord-000248-zueoyesj	1176	46	refine	refine	VB
cord-000248-zueoyesj	1176	47	the	the	DT
cord-000248-zueoyesj	1176	48	region	region	NN
cord-000248-zueoyesj	1176	49	of	of	IN
cord-000248-zueoyesj	1176	50	chromosome	chromosome	NN
cord-000248-zueoyesj	1176	51	20q	20q	NNS
cord-000248-zueoyesj	1176	52	amplification	amplification	NN
cord-000248-zueoyesj	1176	53	in	in	IN
cord-000248-zueoyesj	1176	54	melanoma	melanoma	NN
cord-000248-zueoyesj	1176	55	Identification	identification	NN
cord-000248-zueoyesj	1176	56	of	of	IN
cord-000248-zueoyesj	1176	57	proteins	protein	NNS
cord-000248-zueoyesj	1176	58	regulated	regulate	VBN
cord-000248-zueoyesj	1176	59	by	by	IN
cord-000248-zueoyesj	1176	60	interferon	interferon	NN
cord-000248-zueoyesj	1176	61	-	-	HYPH
cord-000248-zueoyesj	1176	62	alpha	alpha	NN
cord-000248-zueoyesj	1176	63	in	in	IN
cord-000248-zueoyesj	1176	64	resistant	resistant	JJ
cord-000248-zueoyesj	1176	65	and	and	CC
cord-000248-zueoyesj	1176	66	sensitive	sensitive	JJ
cord-000248-zueoyesj	1176	67	malignant	malignant	JJ
cord-000248-zueoyesj	1176	68	melanoma	melanoma	NN
cord-000248-zueoyesj	1176	69	cell	cell	NN
cord-000248-zueoyesj	1176	70	lines	line	NNS
cord-000248-zueoyesj	1177	1	A	a	DT
cord-000248-zueoyesj	1177	2	molecular	molecular	JJ
cord-000248-zueoyesj	1177	3	correlate	correlate	VBP
cord-000248-zueoyesj	1177	4	to	to	IN
cord-000248-zueoyesj	1177	5	the	the	DT
cord-000248-zueoyesj	1177	6	Gleason	Gleason	NNP
cord-000248-zueoyesj	1177	7	grading	grading	NN
cord-000248-zueoyesj	1177	8	system	system	NN
cord-000248-zueoyesj	1177	9	for	for	IN
cord-000248-zueoyesj	1177	10	prostate	prostate	NN
cord-000248-zueoyesj	1177	11	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1177	12	Ink4c	Ink4c	NNP
cord-000248-zueoyesj	1177	13	and	and	CC
cord-000248-zueoyesj	1177	14	Pten	Pten	NNP
cord-000248-zueoyesj	1177	15	constrain	constrain	VBP
cord-000248-zueoyesj	1177	16	a	a	DT
cord-000248-zueoyesj	1177	17	positive	positive	JJ
cord-000248-zueoyesj	1177	18	regulatory	regulatory	JJ
cord-000248-zueoyesj	1177	19	loop	loop	NN
cord-000248-zueoyesj	1177	20	between	between	IN
cord-000248-zueoyesj	1177	21	cell	cell	NN
cord-000248-zueoyesj	1177	22	growth	growth	NN
cord-000248-zueoyesj	1177	23	and	and	CC
cord-000248-zueoyesj	1177	24	cell	cell	NN
cord-000248-zueoyesj	1177	25	cycle	cycle	NN
cord-000248-zueoyesj	1177	26	control	control	NN
cord-000248-zueoyesj	1177	27	Survey	Survey	NNP
cord-000248-zueoyesj	1177	28	of	of	IN
cord-000248-zueoyesj	1177	29	differentially	differentially	RB
cord-000248-zueoyesj	1177	30	methylated	methylate	VBN
cord-000248-zueoyesj	1177	31	promoters	promoter	NNS
cord-000248-zueoyesj	1177	32	in	in	IN
cord-000248-zueoyesj	1177	33	prostate	prostate	NN
cord-000248-zueoyesj	1177	34	cancer	cancer	NN
cord-000248-zueoyesj	1177	35	cell	cell	NN
cord-000248-zueoyesj	1177	36	lines	line	NNS
cord-000248-zueoyesj	1177	37	Transfer	Transfer	NNP
cord-000248-zueoyesj	1177	38	of	of	IN
cord-000248-zueoyesj	1177	39	functional	functional	JJ
cord-000248-zueoyesj	1177	40	prostasomal	prostasomal	JJ
cord-000248-zueoyesj	1177	41	CD59	CD59	NNP
cord-000248-zueoyesj	1177	42	of	of	IN
cord-000248-zueoyesj	1177	43	metastatic	metastatic	JJ
cord-000248-zueoyesj	1177	44	prostatic	prostatic	JJ
cord-000248-zueoyesj	1177	45	cancer	cancer	NN
cord-000248-zueoyesj	1177	46	cell	cell	NN
cord-000248-zueoyesj	1177	47	origin	origin	NN
cord-000248-zueoyesj	1177	48	protects	protect	VBZ
cord-000248-zueoyesj	1177	49	cells	cell	NNS
cord-000248-zueoyesj	1177	50	against	against	IN
cord-000248-zueoyesj	1177	51	complement	complement	JJ
cord-000248-zueoyesj	1177	52	attack	attack	NN
cord-000248-zueoyesj	1177	53	Differentially	differentially	RB
cord-000248-zueoyesj	1177	54	expressed	express	VBD
cord-000248-zueoyesj	1177	55	genes	gene	NNS
cord-000248-zueoyesj	1177	56	in	in	IN
cord-000248-zueoyesj	1177	57	two	two	CD
cord-000248-zueoyesj	1177	58	LNCaP	lncap	NN
cord-000248-zueoyesj	1177	59	prostate	prostate	NN
cord-000248-zueoyesj	1177	60	cancer	cancer	NN
cord-000248-zueoyesj	1177	61	cell	cell	NN
cord-000248-zueoyesj	1177	62	lines	line	NNS
cord-000248-zueoyesj	1177	63	reflecting	reflect	VBG
cord-000248-zueoyesj	1177	64	changes	change	NNS
cord-000248-zueoyesj	1177	65	during	during	IN
cord-000248-zueoyesj	1177	66	prostate	prostate	NN
cord-000248-zueoyesj	1177	67	cancer	cancer	NN
cord-000248-zueoyesj	1177	68	progression	progression	NN
cord-000248-zueoyesj	1177	69	Amine	amine	NN
cord-000248-zueoyesj	1177	70	oxidase	oxidase	NN
cord-000248-zueoyesj	1177	71	activities	activity	NNS
cord-000248-zueoyesj	1177	72	in	in	IN
cord-000248-zueoyesj	1177	73	chemically	chemically	RB
cord-000248-zueoyesj	1177	74	-	-	HYPH
cord-000248-zueoyesj	1177	75	induced	induce	VBN
cord-000248-zueoyesj	1177	76	mammary	mammary	JJ
cord-000248-zueoyesj	1177	77	cancer	cancer	NN
cord-000248-zueoyesj	1177	78	in	in	IN
cord-000248-zueoyesj	1177	79	the	the	DT
cord-000248-zueoyesj	1177	80	rat	rat	NN
cord-000248-zueoyesj	1178	1	The	the	DT
cord-000248-zueoyesj	1178	2	significance	significance	NN
cord-000248-zueoyesj	1178	3	of	of	IN
cord-000248-zueoyesj	1178	4	monoamine	monoamine	NN
cord-000248-zueoyesj	1178	5	oxidase	oxidase	NN
cord-000248-zueoyesj	1178	6	-	-	:
cord-000248-zueoyesj	1178	7	A	a	DT
cord-000248-zueoyesj	1178	8	expression	expression	NN
cord-000248-zueoyesj	1178	9	in	in	IN
cord-000248-zueoyesj	1178	10	high	high	JJ
cord-000248-zueoyesj	1178	11	grade	grade	NN
cord-000248-zueoyesj	1178	12	prostate	prostate	NN
cord-000248-zueoyesj	1178	13	cancer	cancer	NN
cord-000248-zueoyesj	1178	14	From	from	IN
cord-000248-zueoyesj	1178	15	androgen	androgen	NN
cord-000248-zueoyesj	1178	16	receptor	receptor	NN
cord-000248-zueoyesj	1178	17	to	to	IN
cord-000248-zueoyesj	1178	18	the	the	DT
cord-000248-zueoyesj	1178	19	general	general	JJ
cord-000248-zueoyesj	1178	20	transcription	transcription	NN
cord-000248-zueoyesj	1178	21	factor	factor	NN
cord-000248-zueoyesj	1178	22	TFIIH	TFIIH	NNP
cord-000248-zueoyesj	1178	23	.	.	.
cord-000248-zueoyesj	1179	1	Identification	identification	NN
cord-000248-zueoyesj	1179	2	of	of	IN
cord-000248-zueoyesj	1179	3	cdk	cdk	NNP
cord-000248-zueoyesj	1179	4	activating	activate	VBG
cord-000248-zueoyesj	1179	5	kinase	kinase	NN
cord-000248-zueoyesj	1179	6	(	(	-LRB-
cord-000248-zueoyesj	1179	7	CAK	CAK	NNP
cord-000248-zueoyesj	1179	8	)	)	-RRB-
cord-000248-zueoyesj	1179	9	as	as	IN
cord-000248-zueoyesj	1179	10	an	an	DT
cord-000248-zueoyesj	1179	11	androgen	androgen	NN
cord-000248-zueoyesj	1179	12	receptor	receptor	NN
cord-000248-zueoyesj	1179	13	NH(2)-terminal	NH(2)-terminal	NNP
cord-000248-zueoyesj	1179	14	associated	associate	VBD
cord-000248-zueoyesj	1179	15	coactivator	coactivator	NN
cord-000248-zueoyesj	1179	16	Alphamethylacyl	Alphamethylacyl	NNP
cord-000248-zueoyesj	1179	17	-	-	HYPH
cord-000248-zueoyesj	1179	18	CoA	CoA	NNP
cord-000248-zueoyesj	1179	19	racemase	racemase	NN
cord-000248-zueoyesj	1179	20	-	-	:
cord-000248-zueoyesj	1179	21	an	an	DT
cord-000248-zueoyesj	1179	22	'	'	``
cord-000248-zueoyesj	1179	23	obscure	obscure	JJ
cord-000248-zueoyesj	1179	24	'	'	''
cord-000248-zueoyesj	1179	25	metabolic	metabolic	JJ
cord-000248-zueoyesj	1179	26	enzyme	enzyme	NN
cord-000248-zueoyesj	1179	27	takes	take	VBZ
cord-000248-zueoyesj	1179	28	centre	centre	NN
cord-000248-zueoyesj	1179	29	stage	stage	NN
cord-000248-zueoyesj	1179	30	Biopsy	Biopsy	NNP
cord-000248-zueoyesj	1179	31	tissue	tissue	NN
cord-000248-zueoyesj	1179	32	microarray	microarray	NN
cord-000248-zueoyesj	1179	33	study	study	NN
cord-000248-zueoyesj	1179	34	of	of	IN
cord-000248-zueoyesj	1179	35	Ki-67	Ki-67	NNP
cord-000248-zueoyesj	1179	36	expression	expression	NN
cord-000248-zueoyesj	1179	37	in	in	IN
cord-000248-zueoyesj	1179	38	untreated	untreated	JJ
cord-000248-zueoyesj	1179	39	,	,	,
cord-000248-zueoyesj	1179	40	localized	localized	JJ
cord-000248-zueoyesj	1179	41	prostate	prostate	NN
cord-000248-zueoyesj	1179	42	cancer	cancer	NN
cord-000248-zueoyesj	1179	43	managed	manage	VBN
cord-000248-zueoyesj	1179	44	by	by	IN
cord-000248-zueoyesj	1179	45	active	active	JJ
cord-000248-zueoyesj	1179	46	surveillance	surveillance	NN
cord-000248-zueoyesj	1179	47	Alpha	alpha	NN
cord-000248-zueoyesj	1179	48	-	-	HYPH
cord-000248-zueoyesj	1179	49	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1179	50	-	-	HYPH
cord-000248-zueoyesj	1179	51	CoA	coa	NN
cord-000248-zueoyesj	1179	52	racemase	racemase	NN
cord-000248-zueoyesj	1179	53	(	(	-LRB-
cord-000248-zueoyesj	1179	54	P504S	P504S	NNP
cord-000248-zueoyesj	1179	55	)	)	-RRB-
cord-000248-zueoyesj	1179	56	expression	expression	NN
cord-000248-zueoyesj	1179	57	in	in	IN
cord-000248-zueoyesj	1179	58	evolving	evolve	VBG
cord-000248-zueoyesj	1179	59	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1179	60	within	within	IN
cord-000248-zueoyesj	1179	61	benign	benign	JJ
cord-000248-zueoyesj	1179	62	prostatic	prostatic	JJ
cord-000248-zueoyesj	1179	63	hyperplasia	hyperplasia	NN
cord-000248-zueoyesj	1179	64	and	and	CC
cord-000248-zueoyesj	1179	65	in	in	IN
cord-000248-zueoyesj	1179	66	cancers	cancer	NNS
cord-000248-zueoyesj	1179	67	of	of	IN
cord-000248-zueoyesj	1179	68	the	the	DT
cord-000248-zueoyesj	1179	69	transition	transition	NN
cord-000248-zueoyesj	1179	70	zone	zone	NN
cord-000248-zueoyesj	1179	71	Expression	expression	NN
cord-000248-zueoyesj	1179	72	of	of	IN
cord-000248-zueoyesj	1179	73	alpha	alpha	JJ
cord-000248-zueoyesj	1179	74	-	-	HYPH
cord-000248-zueoyesj	1179	75	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1179	76	-	-	HYPH
cord-000248-zueoyesj	1179	77	CoA	coa	NN
cord-000248-zueoyesj	1179	78	racemase	racemase	NN
cord-000248-zueoyesj	1179	79	(	(	-LRB-
cord-000248-zueoyesj	1179	80	P504s	P504s	NNP
cord-000248-zueoyesj	1179	81	)	)	-RRB-
cord-000248-zueoyesj	1179	82	in	in	IN
cord-000248-zueoyesj	1179	83	various	various	JJ
cord-000248-zueoyesj	1179	84	malignant	malignant	JJ
cord-000248-zueoyesj	1179	85	neoplasms	neoplasm	NNS
cord-000248-zueoyesj	1179	86	and	and	CC
cord-000248-zueoyesj	1179	87	normal	normal	JJ
cord-000248-zueoyesj	1179	88	tissues	tissue	NNS
cord-000248-zueoyesj	1179	89	:	:	:
cord-000248-zueoyesj	1179	90	astudy	astudy	NN
cord-000248-zueoyesj	1179	91	of	of	IN
cord-000248-zueoyesj	1179	92	761	761	CD
cord-000248-zueoyesj	1179	93	cases	case	NNS
cord-000248-zueoyesj	1179	94	Using	use	VBG
cord-000248-zueoyesj	1179	95	an	an	DT
cord-000248-zueoyesj	1179	96	AMACR	AMACR	NNP
cord-000248-zueoyesj	1179	97	(	(	-LRB-
cord-000248-zueoyesj	1179	98	P504S)/34betaE12	P504S)/34betaE12	NNP
cord-000248-zueoyesj	1179	99	/	/	SYM
cord-000248-zueoyesj	1179	100	p63	p63	CD
cord-000248-zueoyesj	1179	101	cocktail	cocktail	NN
cord-000248-zueoyesj	1179	102	for	for	IN
cord-000248-zueoyesj	1179	103	the	the	DT
cord-000248-zueoyesj	1179	104	detection	detection	NN
cord-000248-zueoyesj	1179	105	of	of	IN
cord-000248-zueoyesj	1179	106	small	small	JJ
cord-000248-zueoyesj	1179	107	focal	focal	JJ
cord-000248-zueoyesj	1179	108	prostate	prostate	NN
cord-000248-zueoyesj	1179	109	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1179	110	in	in	IN
cord-000248-zueoyesj	1179	111	needle	needle	NN
cord-000248-zueoyesj	1179	112	biopsy	biopsy	NN
cord-000248-zueoyesj	1179	113	specimens	specimen	NNS
cord-000248-zueoyesj	1179	114	Diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1179	115	utility	utility	NN
cord-000248-zueoyesj	1179	116	of	of	IN
cord-000248-zueoyesj	1179	117	alpha	alpha	JJ
cord-000248-zueoyesj	1179	118	-	-	HYPH
cord-000248-zueoyesj	1179	119	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1179	120	CoA	coa	NN
cord-000248-zueoyesj	1179	121	racemase	racemase	NNP
cord-000248-zueoyesj	1179	122	(	(	-LRB-
cord-000248-zueoyesj	1179	123	P504S	P504S	NNP
cord-000248-zueoyesj	1179	124	)	)	-RRB-
cord-000248-zueoyesj	1179	125	on	on	IN
cord-000248-zueoyesj	1179	126	prostate	prostate	NN
cord-000248-zueoyesj	1179	127	needle	needle	NN
cord-000248-zueoyesj	1179	128	biopsy	biopsy	NN
cord-000248-zueoyesj	1179	129	Discovery	Discovery	NNP
cord-000248-zueoyesj	1179	130	and	and	CC
cord-000248-zueoyesj	1179	131	clinical	clinical	JJ
cord-000248-zueoyesj	1179	132	application	application	NN
cord-000248-zueoyesj	1179	133	of	of	IN
cord-000248-zueoyesj	1179	134	a	a	DT
cord-000248-zueoyesj	1179	135	novel	novel	JJ
cord-000248-zueoyesj	1179	136	prostate	prostate	NN
cord-000248-zueoyesj	1179	137	cancer	cancer	NN
cord-000248-zueoyesj	1179	138	marker	marker	NN
cord-000248-zueoyesj	1179	139	:	:	:
cord-000248-zueoyesj	1179	140	alpha	alpha	NN
cord-000248-zueoyesj	1179	141	-	-	HYPH
cord-000248-zueoyesj	1179	142	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1179	143	CoA	coa	NN
cord-000248-zueoyesj	1179	144	racemase	racemase	NNP
cord-000248-zueoyesj	1180	1	(	(	-LRB-
cord-000248-zueoyesj	1180	2	P504S	P504S	NNP
cord-000248-zueoyesj	1180	3	)	)	-RRB-
cord-000248-zueoyesj	1180	4	Alphamethylacyl	Alphamethylacyl	NNP
cord-000248-zueoyesj	1180	5	-	-	HYPH
cord-000248-zueoyesj	1180	6	CoA	CoA	NNP
cord-000248-zueoyesj	1180	7	racemase	racemase	NN
cord-000248-zueoyesj	1180	8	:	:	:
cord-000248-zueoyesj	1180	9	a	a	DT
cord-000248-zueoyesj	1180	10	multi	multi	JJ
cord-000248-zueoyesj	1180	11	-	-	JJ
cord-000248-zueoyesj	1180	12	institutional	institutional	JJ
cord-000248-zueoyesj	1180	13	study	study	NN
cord-000248-zueoyesj	1180	14	of	of	IN
cord-000248-zueoyesj	1180	15	a	a	DT
cord-000248-zueoyesj	1180	16	new	new	JJ
cord-000248-zueoyesj	1180	17	prostate	prostate	NN
cord-000248-zueoyesj	1180	18	cancer	cancer	NN
cord-000248-zueoyesj	1180	19	marker	marker	NN
cord-000248-zueoyesj	1180	20	Quantitative	quantitative	JJ
cord-000248-zueoyesj	1180	21	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1180	22	detection	detection	NN
cord-000248-zueoyesj	1180	23	of	of	IN
cord-000248-zueoyesj	1180	24	the	the	DT
cord-000248-zueoyesj	1180	25	molecular	molecular	JJ
cord-000248-zueoyesj	1180	26	expression	expression	NN
cord-000248-zueoyesj	1180	27	patterns	pattern	NNS
cord-000248-zueoyesj	1180	28	in	in	IN
cord-000248-zueoyesj	1180	29	proliferative	proliferative	JJ
cord-000248-zueoyesj	1180	30	inflammatory	inflammatory	JJ
cord-000248-zueoyesj	1180	31	atrophy	atrophy	NN
cord-000248-zueoyesj	1181	1	The	the	DT
cord-000248-zueoyesj	1181	2	importance	importance	NN
cord-000248-zueoyesj	1181	3	of	of	IN
cord-000248-zueoyesj	1181	4	determining	determine	VBG
cord-000248-zueoyesj	1181	5	the	the	DT
cord-000248-zueoyesj	1181	6	aggressiveness	aggressiveness	NN
cord-000248-zueoyesj	1181	7	of	of	IN
cord-000248-zueoyesj	1181	8	prostate	prostate	NN
cord-000248-zueoyesj	1181	9	cancer	cancer	NN
cord-000248-zueoyesj	1181	10	using	use	VBG
cord-000248-zueoyesj	1181	11	serum	serum	NN
cord-000248-zueoyesj	1181	12	and	and	CC
cord-000248-zueoyesj	1181	13	tissue	tissue	NN
cord-000248-zueoyesj	1181	14	molecular	molecular	JJ
cord-000248-zueoyesj	1181	15	markers	marker	NNS
cord-000248-zueoyesj	1181	16	GOLPH2	GOLPH2	NNP
cord-000248-zueoyesj	1181	17	protein	protein	NN
cord-000248-zueoyesj	1181	18	expression	expression	NN
cord-000248-zueoyesj	1181	19	as	as	IN
cord-000248-zueoyesj	1181	20	a	a	DT
cord-000248-zueoyesj	1181	21	novel	novel	JJ
cord-000248-zueoyesj	1181	22	tissue	tissue	NN
cord-000248-zueoyesj	1181	23	biomarker	biomarker	NN
cord-000248-zueoyesj	1181	24	for	for	IN
cord-000248-zueoyesj	1181	25	prostate	prostate	NN
cord-000248-zueoyesj	1181	26	cancer	cancer	NN
cord-000248-zueoyesj	1181	27	:	:	:
cord-000248-zueoyesj	1181	28	implications	implication	NNS
cord-000248-zueoyesj	1181	29	for	for	IN
cord-000248-zueoyesj	1181	30	tissue	tissue	NN
cord-000248-zueoyesj	1181	31	-	-	HYPH
cord-000248-zueoyesj	1181	32	based	base	VBN
cord-000248-zueoyesj	1181	33	diagnostics	diagnostic	NNS
cord-000248-zueoyesj	1181	34	Optimization	Optimization	NNP
cord-000248-zueoyesj	1181	35	of	of	IN
cord-000248-zueoyesj	1181	36	laser	laser	NN
cord-000248-zueoyesj	1181	37	capture	capture	NN
cord-000248-zueoyesj	1181	38	microdissection	microdissection	NN
cord-000248-zueoyesj	1181	39	and	and	CC
cord-000248-zueoyesj	1181	40	RNA	RNA	NNP
cord-000248-zueoyesj	1181	41	amplification	amplification	NN
cord-000248-zueoyesj	1181	42	for	for	IN
cord-000248-zueoyesj	1181	43	gene	gene	NN
cord-000248-zueoyesj	1181	44	expression	expression	NN
cord-000248-zueoyesj	1181	45	profiling	profiling	NN
cord-000248-zueoyesj	1181	46	of	of	IN
cord-000248-zueoyesj	1181	47	prostate	prostate	NN
cord-000248-zueoyesj	1181	48	cancer	cancer	NN
cord-000248-zueoyesj	1181	49	)	)	-RRB-
cord-000248-zueoyesj	1182	1	alpha	alpha	NN
cord-000248-zueoyesj	1182	2	-	-	HYPH
cord-000248-zueoyesj	1182	3	Methylacyl	Methylacyl	NNP
cord-000248-zueoyesj	1182	4	-	-	HYPH
cord-000248-zueoyesj	1182	5	CoA	CoA	NNP
cord-000248-zueoyesj	1182	6	racemase	racemase	NN
cord-000248-zueoyesj	1182	7	:	:	:
cord-000248-zueoyesj	1182	8	expression	expression	NN
cord-000248-zueoyesj	1182	9	levels	level	NNS
cord-000248-zueoyesj	1182	10	of	of	IN
cord-000248-zueoyesj	1182	11	this	this	DT
cord-000248-zueoyesj	1182	12	novel	novel	JJ
cord-000248-zueoyesj	1182	13	cancer	cancer	NN
cord-000248-zueoyesj	1182	14	biomarker	biomarker	NN
cord-000248-zueoyesj	1182	15	depend	depend	VBP
cord-000248-zueoyesj	1182	16	on	on	IN
cord-000248-zueoyesj	1182	17	tumor	tumor	NN
cord-000248-zueoyesj	1182	18	differentiation	differentiation	NN
cord-000248-zueoyesj	1183	1	Elevated	elevated	JJ
cord-000248-zueoyesj	1183	2	alpha	alpha	NN
cord-000248-zueoyesj	1183	3	-	-	HYPH
cord-000248-zueoyesj	1183	4	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1183	5	-	-	HYPH
cord-000248-zueoyesj	1183	6	CoA	coa	NN
cord-000248-zueoyesj	1183	7	racemase	racemase	NN
cord-000248-zueoyesj	1183	8	enzymatic	enzymatic	JJ
cord-000248-zueoyesj	1183	9	activity	activity	NN
cord-000248-zueoyesj	1183	10	in	in	IN
cord-000248-zueoyesj	1183	11	prostate	prostate	NN
cord-000248-zueoyesj	1183	12	cancer	cancer	NN
cord-000248-zueoyesj	1183	13	Comparison	comparison	NN
cord-000248-zueoyesj	1183	14	of	of	IN
cord-000248-zueoyesj	1183	15	monoclonal	monoclonal	JJ
cord-000248-zueoyesj	1183	16	antibody	antibody	NN
cord-000248-zueoyesj	1183	17	(	(	-LRB-
cord-000248-zueoyesj	1183	18	P504S	P504S	NNP
cord-000248-zueoyesj	1183	19	)	)	-RRB-
cord-000248-zueoyesj	1183	20	and	and	CC
cord-000248-zueoyesj	1183	21	polyclonal	polyclonal	JJ
cord-000248-zueoyesj	1183	22	antibody	antibody	NN
cord-000248-zueoyesj	1183	23	to	to	IN
cord-000248-zueoyesj	1183	24	alpha	alpha	NNP
cord-000248-zueoyesj	1183	25	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1183	26	-	-	HYPH
cord-000248-zueoyesj	1183	27	CoA	coa	NN
cord-000248-zueoyesj	1183	28	racemase	racemase	NN
cord-000248-zueoyesj	1183	29	(	(	-LRB-
cord-000248-zueoyesj	1183	30	AMACR	AMACR	NNP
cord-000248-zueoyesj	1183	31	)	)	-RRB-
cord-000248-zueoyesj	1183	32	in	in	IN
cord-000248-zueoyesj	1183	33	the	the	DT
cord-000248-zueoyesj	1183	34	work	work	NN
cord-000248-zueoyesj	1183	35	-	-	HYPH
cord-000248-zueoyesj	1183	36	up	up	NN
cord-000248-zueoyesj	1183	37	of	of	IN
cord-000248-zueoyesj	1183	38	prostate	prostate	NN
cord-000248-zueoyesj	1183	39	cancer	cancer	NN
cord-000248-zueoyesj	1183	40	Immunohistochemical	Immunohistochemical	NNP
cord-000248-zueoyesj	1183	41	detection	detection	NN
cord-000248-zueoyesj	1183	42	of	of	IN
cord-000248-zueoyesj	1183	43	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1183	44	in	in	IN
cord-000248-zueoyesj	1183	45	radical	radical	JJ
cord-000248-zueoyesj	1183	46	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1183	47	specimens	specimen	NNS
cord-000248-zueoyesj	1183	48	following	follow	VBG
cord-000248-zueoyesj	1183	49	hormone	hormone	NN
cord-000248-zueoyesj	1183	50	therapy	therapy	NN
cord-000248-zueoyesj	1183	51	Basal	Basal	NNP
cord-000248-zueoyesj	1183	52	cell	cell	NN
cord-000248-zueoyesj	1183	53	subpopulation	subpopulation	NN
cord-000248-zueoyesj	1183	54	as	as	IN
cord-000248-zueoyesj	1183	55	putative	putative	JJ
cord-000248-zueoyesj	1183	56	human	human	JJ
cord-000248-zueoyesj	1183	57	prostate	prostate	NN
cord-000248-zueoyesj	1183	58	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1183	59	stem	stem	NN
cord-000248-zueoyesj	1183	60	cells	cell	NNS
cord-000248-zueoyesj	1184	1	A	a	DT
cord-000248-zueoyesj	1184	2	statistical	statistical	JJ
cord-000248-zueoyesj	1184	3	method	method	NN
cord-000248-zueoyesj	1184	4	for	for	IN
cord-000248-zueoyesj	1184	5	identifying	identify	VBG
cord-000248-zueoyesj	1184	6	differential	differential	JJ
cord-000248-zueoyesj	1184	7	gene	gene	NN
cord-000248-zueoyesj	1184	8	-	-	HYPH
cord-000248-zueoyesj	1184	9	gene	gene	NN
cord-000248-zueoyesj	1184	10	co	co	NN
cord-000248-zueoyesj	1184	11	-	-	JJ
cord-000248-zueoyesj	1184	12	expression	expression	JJ
cord-000248-zueoyesj	1184	13	patterns	pattern	NNS
cord-000248-zueoyesj	1184	14	Alphamethylacyl	Alphamethylacyl	NNP
cord-000248-zueoyesj	1184	15	-	-	HYPH
cord-000248-zueoyesj	1184	16	CoA	coa	NN
cord-000248-zueoyesj	1184	17	racemase	racemase	NN
cord-000248-zueoyesj	1184	18	(	(	-LRB-
cord-000248-zueoyesj	1184	19	AMACR	AMACR	NNP
cord-000248-zueoyesj	1184	20	/	/	SYM
cord-000248-zueoyesj	1184	21	P504S	P504S	NNP
cord-000248-zueoyesj	1184	22	)	)	-RRB-
cord-000248-zueoyesj	1184	23	protein	protein	NN
cord-000248-zueoyesj	1184	24	expression	expression	NN
cord-000248-zueoyesj	1184	25	in	in	IN
cord-000248-zueoyesj	1184	26	urothelial	urothelial	JJ
cord-000248-zueoyesj	1184	27	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1184	28	of	of	IN
cord-000248-zueoyesj	1184	29	the	the	DT
cord-000248-zueoyesj	1184	30	upper	upper	JJ
cord-000248-zueoyesj	1184	31	urinary	urinary	JJ
cord-000248-zueoyesj	1184	32	tract	tract	NN
cord-000248-zueoyesj	1184	33	correlates	correlate	VBZ
cord-000248-zueoyesj	1184	34	with	with	IN
cord-000248-zueoyesj	1184	35	tumour	tumour	NN
cord-000248-zueoyesj	1184	36	progression	progression	NN
cord-000248-zueoyesj	1184	37	Sequence	sequence	NN
cord-000248-zueoyesj	1184	38	variation	variation	NN
cord-000248-zueoyesj	1184	39	in	in	IN
cord-000248-zueoyesj	1184	40	alpha	alpha	JJ
cord-000248-zueoyesj	1184	41	-	-	HYPH
cord-000248-zueoyesj	1184	42	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1184	43	-	-	HYPH
cord-000248-zueoyesj	1184	44	CoA	coa	NN
cord-000248-zueoyesj	1184	45	racemase	racemase	NN
cord-000248-zueoyesj	1184	46	and	and	CC
cord-000248-zueoyesj	1184	47	risk	risk	NN
cord-000248-zueoyesj	1184	48	of	of	IN
cord-000248-zueoyesj	1184	49	early	early	JJ
cord-000248-zueoyesj	1184	50	-	-	HYPH
cord-000248-zueoyesj	1184	51	onset	onset	NN
cord-000248-zueoyesj	1184	52	and	and	CC
cord-000248-zueoyesj	1184	53	familial	familial	JJ
cord-000248-zueoyesj	1184	54	prostate	prostate	NN
cord-000248-zueoyesj	1184	55	cancer	cancer	NN
cord-000248-zueoyesj	1184	56	Malignant	malignant	JJ
cord-000248-zueoyesj	1184	57	transformation	transformation	NN
cord-000248-zueoyesj	1184	58	of	of	IN
cord-000248-zueoyesj	1184	59	human	human	JJ
cord-000248-zueoyesj	1184	60	benign	benign	JJ
cord-000248-zueoyesj	1184	61	prostate	prostate	NN
cord-000248-zueoyesj	1184	62	epithelial	epithelial	JJ
cord-000248-zueoyesj	1184	63	cells	cell	NNS
cord-000248-zueoyesj	1184	64	by	by	IN
cord-000248-zueoyesj	1184	65	high	high	JJ
cord-000248-zueoyesj	1184	66	linear	linear	JJ
cord-000248-zueoyesj	1184	67	energy	energy	NN
cord-000248-zueoyesj	1184	68	transfer	transfer	NN
cord-000248-zueoyesj	1184	69	alpha	alpha	NN
cord-000248-zueoyesj	1184	70	-	-	HYPH
cord-000248-zueoyesj	1184	71	particles	particle	NNS
cord-000248-zueoyesj	1184	72	Expression	expression	NN
cord-000248-zueoyesj	1184	73	of	of	IN
cord-000248-zueoyesj	1184	74	alpha	alpha	NN
cord-000248-zueoyesj	1184	75	-	-	HYPH
cord-000248-zueoyesj	1184	76	methylacylcoenzyme	methylacylcoenzyme	NNS
cord-000248-zueoyesj	1185	1	A	a	DT
cord-000248-zueoyesj	1185	2	racemase	racemase	NN
cord-000248-zueoyesj	1185	3	in	in	IN
cord-000248-zueoyesj	1185	4	dysplastic	dysplastic	JJ
cord-000248-zueoyesj	1185	5	Barrett	Barrett	NNP
cord-000248-zueoyesj	1185	6	's	's	POS
cord-000248-zueoyesj	1185	7	epithelium	epithelium	NN
cord-000248-zueoyesj	1185	8	Quantitative	quantitative	JJ
cord-000248-zueoyesj	1185	9	analysis	analysis	NN
cord-000248-zueoyesj	1185	10	of	of	IN
cord-000248-zueoyesj	1185	11	a	a	DT
cord-000248-zueoyesj	1185	12	panel	panel	NN
cord-000248-zueoyesj	1185	13	of	of	IN
cord-000248-zueoyesj	1185	14	gene	gene	NN
cord-000248-zueoyesj	1185	15	expression	expression	NN
cord-000248-zueoyesj	1185	16	in	in	IN
cord-000248-zueoyesj	1185	17	prostate	prostate	NN
cord-000248-zueoyesj	1185	18	cancer	cancer	NN
cord-000248-zueoyesj	1185	19	-	-	HYPH
cord-000248-zueoyesj	1185	20	with	with	IN
cord-000248-zueoyesj	1185	21	emphasis	emphasis	NN
cord-000248-zueoyesj	1185	22	on	on	IN
cord-000248-zueoyesj	1185	23	NPY	NPY	NNP
cord-000248-zueoyesj	1185	24	expression	expression	NN
cord-000248-zueoyesj	1185	25	analysis	analysis	NN
cord-000248-zueoyesj	1186	1	The	the	DT
cord-000248-zueoyesj	1186	2	value	value	NN
cord-000248-zueoyesj	1186	3	of	of	IN
cord-000248-zueoyesj	1186	4	using	use	VBG
cord-000248-zueoyesj	1186	5	an	an	DT
cord-000248-zueoyesj	1186	6	AMACR/34betaE12	AMACR/34betaE12	NNP
cord-000248-zueoyesj	1186	7	/	/	SYM
cord-000248-zueoyesj	1186	8	p63	p63	CD
cord-000248-zueoyesj	1186	9	cocktail	cocktail	NN
cord-000248-zueoyesj	1186	10	double	double	JJ
cord-000248-zueoyesj	1186	11	staining	staining	NN
cord-000248-zueoyesj	1186	12	for	for	IN
cord-000248-zueoyesj	1186	13	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1186	14	of	of	IN
cord-000248-zueoyesj	1186	15	prostate	prostate	NN
cord-000248-zueoyesj	1186	16	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1186	17	Decreased	decrease	VBD
cord-000248-zueoyesj	1186	18	gene	gene	NN
cord-000248-zueoyesj	1186	19	expression	expression	NN
cord-000248-zueoyesj	1186	20	of	of	IN
cord-000248-zueoyesj	1186	21	steroid	steroid	NN
cord-000248-zueoyesj	1186	22	5	5	CD
cord-000248-zueoyesj	1186	23	alpha	alpha	NN
cord-000248-zueoyesj	1186	24	-	-	HYPH
cord-000248-zueoyesj	1186	25	reductase	reductase	NN
cord-000248-zueoyesj	1186	26	2	2	CD
cord-000248-zueoyesj	1186	27	in	in	IN
cord-000248-zueoyesj	1186	28	human	human	JJ
cord-000248-zueoyesj	1186	29	prostate	prostate	NN
cord-000248-zueoyesj	1186	30	cancer	cancer	NN
cord-000248-zueoyesj	1186	31	:	:	:
cord-000248-zueoyesj	1186	32	implications	implication	NNS
cord-000248-zueoyesj	1186	33	for	for	IN
cord-000248-zueoyesj	1186	34	finasteride	finasteride	NN
cord-000248-zueoyesj	1186	35	therapy	therapy	NN
cord-000248-zueoyesj	1186	36	of	of	IN
cord-000248-zueoyesj	1186	37	prostate	prostate	NN
cord-000248-zueoyesj	1186	38	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1186	39	Alpha	alpha	NN
cord-000248-zueoyesj	1186	40	-	-	HYPH
cord-000248-zueoyesj	1186	41	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1186	42	-	-	HYPH
cord-000248-zueoyesj	1186	43	CoA	coa	NN
cord-000248-zueoyesj	1186	44	racemase	racemase	NN
cord-000248-zueoyesj	1186	45	:	:	:
cord-000248-zueoyesj	1186	46	a	a	DT
cord-000248-zueoyesj	1186	47	new	new	JJ
cord-000248-zueoyesj	1186	48	molecular	molecular	JJ
cord-000248-zueoyesj	1186	49	marker	marker	NN
cord-000248-zueoyesj	1186	50	for	for	IN
cord-000248-zueoyesj	1186	51	prostate	prostate	NN
cord-000248-zueoyesj	1186	52	cancer	cancer	NN
cord-000248-zueoyesj	1186	53	Alpha	alpha	NN
cord-000248-zueoyesj	1186	54	-	-	HYPH
cord-000248-zueoyesj	1186	55	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1186	56	-	-	HYPH
cord-000248-zueoyesj	1186	57	CoA	coa	NN
cord-000248-zueoyesj	1186	58	racemase	racemase	NN
cord-000248-zueoyesj	1186	59	:	:	:
cord-000248-zueoyesj	1186	60	a	a	DT
cord-000248-zueoyesj	1186	61	variably	variably	RB
cord-000248-zueoyesj	1186	62	sensitive	sensitive	JJ
cord-000248-zueoyesj	1186	63	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1186	64	marker	marker	NN
cord-000248-zueoyesj	1186	65	for	for	IN
cord-000248-zueoyesj	1186	66	the	the	DT
cord-000248-zueoyesj	1186	67	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1186	68	of	of	IN
cord-000248-zueoyesj	1186	69	small	small	JJ
cord-000248-zueoyesj	1186	70	prostate	prostate	NN
cord-000248-zueoyesj	1186	71	cancer	cancer	NN
cord-000248-zueoyesj	1186	72	foci	foci	NN
cord-000248-zueoyesj	1186	73	on	on	IN
cord-000248-zueoyesj	1186	74	needle	needle	NN
cord-000248-zueoyesj	1186	75	biopsy	biopsy	NN
cord-000248-zueoyesj	1186	76	Neoadjuvant	Neoadjuvant	NNP
cord-000248-zueoyesj	1186	77	docetaxel	docetaxel	VBD
cord-000248-zueoyesj	1186	78	treatment	treatment	NN
cord-000248-zueoyesj	1186	79	for	for	IN
cord-000248-zueoyesj	1186	80	locally	locally	RB
cord-000248-zueoyesj	1186	81	advanced	advanced	JJ
cord-000248-zueoyesj	1186	82	prostate	prostate	NN
cord-000248-zueoyesj	1186	83	cancer	cancer	NN
cord-000248-zueoyesj	1186	84	:	:	:
cord-000248-zueoyesj	1186	85	a	a	DT
cord-000248-zueoyesj	1186	86	clinicopathologic	clinicopathologic	JJ
cord-000248-zueoyesj	1186	87	study	study	NN
cord-000248-zueoyesj	1186	88	Biomarkers	Biomarkers	NNPS
cord-000248-zueoyesj	1186	89	for	for	IN
cord-000248-zueoyesj	1186	90	Prostate	Prostate	NNP
cord-000248-zueoyesj	1186	91	Cancer	Cancer	NNP
cord-000248-zueoyesj	1186	92	Method	Method	NNP
cord-000248-zueoyesj	1186	93	for	for	IN
cord-000248-zueoyesj	1186	94	quantification	quantification	NN
cord-000248-zueoyesj	1186	95	of	of	IN
cord-000248-zueoyesj	1186	96	a	a	DT
cord-000248-zueoyesj	1186	97	prostate	prostate	NN
cord-000248-zueoyesj	1186	98	cancer	cancer	NN
cord-000248-zueoyesj	1186	99	biomarker	biomarker	NN
cord-000248-zueoyesj	1186	100	in	in	IN
cord-000248-zueoyesj	1186	101	urine	urine	NN
cord-000248-zueoyesj	1186	102	without	without	IN
cord-000248-zueoyesj	1186	103	sample	sample	NN
cord-000248-zueoyesj	1186	104	preparation	preparation	NN
cord-000248-zueoyesj	1186	105	Effects	effect	NNS
cord-000248-zueoyesj	1186	106	of	of	IN
cord-000248-zueoyesj	1186	107	the	the	DT
cord-000248-zueoyesj	1186	108	dual	dual	JJ
cord-000248-zueoyesj	1186	109	5	5	CD
cord-000248-zueoyesj	1186	110	alpha	alpha	NN
cord-000248-zueoyesj	1186	111	-	-	HYPH
cord-000248-zueoyesj	1186	112	reductase	reductase	NN
cord-000248-zueoyesj	1186	113	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1186	114	dutasteride	dutasteride	NN
cord-000248-zueoyesj	1186	115	on	on	IN
cord-000248-zueoyesj	1186	116	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1186	117	in	in	IN
cord-000248-zueoyesj	1186	118	primary	primary	JJ
cord-000248-zueoyesj	1186	119	cultures	culture	NNS
cord-000248-zueoyesj	1186	120	of	of	IN
cord-000248-zueoyesj	1186	121	prostate	prostate	NN
cord-000248-zueoyesj	1186	122	cancer	cancer	NN
cord-000248-zueoyesj	1186	123	epithelial	epithelial	JJ
cord-000248-zueoyesj	1186	124	cells	cell	NNS
cord-000248-zueoyesj	1186	125	and	and	CC
cord-000248-zueoyesj	1186	126	cell	cell	NN
cord-000248-zueoyesj	1186	127	lines	line	NNS
cord-000248-zueoyesj	1187	1	Routine	routine	JJ
cord-000248-zueoyesj	1187	2	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1187	3	staining	stain	VBG
cord-000248-zueoyesj	1187	4	for	for	IN
cord-000248-zueoyesj	1187	5	high	high	JJ
cord-000248-zueoyesj	1187	6	-	-	HYPH
cord-000248-zueoyesj	1187	7	molecular	molecular	JJ
cord-000248-zueoyesj	1187	8	weight	weight	NN
cord-000248-zueoyesj	1187	9	cytokeratin	cytokeratin	NNP
cord-000248-zueoyesj	1187	10	34-beta	34-beta	CD
cord-000248-zueoyesj	1187	11	and	and	CC
cord-000248-zueoyesj	1187	12	alpha	alpha	NN
cord-000248-zueoyesj	1187	13	-	-	HYPH
cord-000248-zueoyesj	1187	14	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1187	15	CoA	coa	NN
cord-000248-zueoyesj	1187	16	racemase	racemase	NNP
cord-000248-zueoyesj	1187	17	(	(	-LRB-
cord-000248-zueoyesj	1187	18	P504S	P504S	NNP
cord-000248-zueoyesj	1187	19	)	)	-RRB-
cord-000248-zueoyesj	1187	20	in	in	IN
cord-000248-zueoyesj	1187	21	postirradiation	postirradiation	NN
cord-000248-zueoyesj	1187	22	prostate	prostate	NN
cord-000248-zueoyesj	1187	23	biopsies	biopsy	NNS
cord-000248-zueoyesj	1187	24	Search	search	VBP
cord-000248-zueoyesj	1187	25	for	for	IN
cord-000248-zueoyesj	1187	26	residual	residual	JJ
cord-000248-zueoyesj	1187	27	prostate	prostate	NN
cord-000248-zueoyesj	1187	28	cancer	cancer	NN
cord-000248-zueoyesj	1187	29	on	on	IN
cord-000248-zueoyesj	1187	30	pT0	pt0	NN
cord-000248-zueoyesj	1187	31	radical	radical	JJ
cord-000248-zueoyesj	1187	32	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1187	33	after	after	IN
cord-000248-zueoyesj	1187	34	positive	positive	JJ
cord-000248-zueoyesj	1187	35	biopsy	biopsy	NN
cord-000248-zueoyesj	1187	36	Branched	branch	VBD
cord-000248-zueoyesj	1187	37	fatty	fatty	JJ
cord-000248-zueoyesj	1187	38	acids	acid	NNS
cord-000248-zueoyesj	1187	39	in	in	IN
cord-000248-zueoyesj	1187	40	dairy	dairy	NN
cord-000248-zueoyesj	1187	41	and	and	CC
cord-000248-zueoyesj	1187	42	beef	beef	NN
cord-000248-zueoyesj	1187	43	products	product	NNS
cord-000248-zueoyesj	1187	44	markedly	markedly	RB
cord-000248-zueoyesj	1187	45	enhance	enhance	VBP
cord-000248-zueoyesj	1187	46	alpha	alpha	NN
cord-000248-zueoyesj	1187	47	-	-	HYPH
cord-000248-zueoyesj	1187	48	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1187	49	-	-	HYPH
cord-000248-zueoyesj	1187	50	CoA	coa	NN
cord-000248-zueoyesj	1187	51	racemase	racemase	NN
cord-000248-zueoyesj	1187	52	expression	expression	NN
cord-000248-zueoyesj	1187	53	in	in	IN
cord-000248-zueoyesj	1187	54	prostate	prostate	NN
cord-000248-zueoyesj	1187	55	cancer	cancer	NN
cord-000248-zueoyesj	1187	56	cells	cell	NNS
cord-000248-zueoyesj	1187	57	in	in	IN
cord-000248-zueoyesj	1187	58	vitro	vitro	FW
cord-000248-zueoyesj	1187	59	Alpha	alpha	NN
cord-000248-zueoyesj	1187	60	-	-	HYPH
cord-000248-zueoyesj	1187	61	methyl	methyl	NN
cord-000248-zueoyesj	1187	62	CoA	coa	NN
cord-000248-zueoyesj	1187	63	racemase	racemase	NN
cord-000248-zueoyesj	1187	64	expression	expression	NN
cord-000248-zueoyesj	1187	65	in	in	IN
cord-000248-zueoyesj	1187	66	renal	renal	JJ
cord-000248-zueoyesj	1187	67	cell	cell	NN
cord-000248-zueoyesj	1187	68	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1187	69	Diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1187	70	utility	utility	NN
cord-000248-zueoyesj	1187	71	of	of	IN
cord-000248-zueoyesj	1187	72	a	a	DT
cord-000248-zueoyesj	1187	73	p63	p63	CD
cord-000248-zueoyesj	1187	74	/	/	SYM
cord-000248-zueoyesj	1187	75	alpha	alpha	NN
cord-000248-zueoyesj	1187	76	-	-	HYPH
cord-000248-zueoyesj	1187	77	methyl	methyl	JJ
cord-000248-zueoyesj	1187	78	-	-	HYPH
cord-000248-zueoyesj	1187	79	CoA	coa	NN
cord-000248-zueoyesj	1187	80	-	-	HYPH
cord-000248-zueoyesj	1187	81	racemase	racemase	NNP
cord-000248-zueoyesj	1187	82	(	(	-LRB-
cord-000248-zueoyesj	1187	83	p504s	p504s	CD
cord-000248-zueoyesj	1187	84	)	)	-RRB-
cord-000248-zueoyesj	1187	85	cocktail	cocktail	NN
cord-000248-zueoyesj	1187	86	in	in	IN
cord-000248-zueoyesj	1187	87	atypical	atypical	JJ
cord-000248-zueoyesj	1187	88	foci	focus	NNS
cord-000248-zueoyesj	1187	89	in	in	IN
cord-000248-zueoyesj	1187	90	the	the	DT
cord-000248-zueoyesj	1187	91	prostate	prostate	NN
cord-000248-zueoyesj	1187	92	Value	value	NN
cord-000248-zueoyesj	1187	93	of	of	IN
cord-000248-zueoyesj	1187	94	new	new	JJ
cord-000248-zueoyesj	1187	95	prostate	prostate	NN
cord-000248-zueoyesj	1187	96	cancer	cancer	NN
cord-000248-zueoyesj	1187	97	markers	marker	NNS
cord-000248-zueoyesj	1187	98	:	:	:
cord-000248-zueoyesj	1187	99	alpha	alpha	NNP
cord-000248-zueoyesj	1187	100	methylacyl	methylacyl	NNP
cord-000248-zueoyesj	1187	101	CoA	CoA	NNP
cord-000248-zueoyesj	1187	102	racemase	racemase	NNP
cord-000248-zueoyesj	1187	103	(	(	-LRB-
cord-000248-zueoyesj	1187	104	P504S	P504S	NNP
cord-000248-zueoyesj	1187	105	)	)	-RRB-
cord-000248-zueoyesj	1187	106	and	and	CC
cord-000248-zueoyesj	1187	107	p63	p63	NNP
cord-000248-zueoyesj	1187	108	Evaluation	Evaluation	NNP
cord-000248-zueoyesj	1187	109	of	of	IN
cord-000248-zueoyesj	1187	110	p63	p63	CD
cord-000248-zueoyesj	1187	111	and	and	CC
cord-000248-zueoyesj	1187	112	p504s	p504s	CD
cord-000248-zueoyesj	1187	113	markers	marker	NNS
cord-000248-zueoyesj	1187	114	for	for	IN
cord-000248-zueoyesj	1187	115	the	the	DT
cord-000248-zueoyesj	1187	116	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1187	117	of	of	IN
cord-000248-zueoyesj	1187	118	prostate	prostate	NN
cord-000248-zueoyesj	1187	119	cancer	cancer	NN
cord-000248-zueoyesj	1187	120	A	a	DT
cord-000248-zueoyesj	1187	121	preliminary	preliminary	JJ
cord-000248-zueoyesj	1187	122	study	study	NN
cord-000248-zueoyesj	1187	123	of	of	IN
cord-000248-zueoyesj	1187	124	the	the	DT
cord-000248-zueoyesj	1187	125	baboon	baboon	NN
cord-000248-zueoyesj	1187	126	prostate	prostate	NN
cord-000248-zueoyesj	1187	127	pathophysiology	pathophysiology	NN
cord-000248-zueoyesj	1187	128	Alternative	alternative	JJ
cord-000248-zueoyesj	1187	129	spliced	splice	VBN
cord-000248-zueoyesj	1187	130	variants	variant	NNS
cord-000248-zueoyesj	1187	131	of	of	IN
cord-000248-zueoyesj	1187	132	the	the	DT
cord-000248-zueoyesj	1187	133	alpha	alpha	JJ
cord-000248-zueoyesj	1187	134	-	-	HYPH
cord-000248-zueoyesj	1187	135	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1187	136	-	-	HYPH
cord-000248-zueoyesj	1187	137	CoA	coa	NN
cord-000248-zueoyesj	1187	138	racemase	racemase	NN
cord-000248-zueoyesj	1187	139	gene	gene	NN
cord-000248-zueoyesj	1187	140	and	and	CC
cord-000248-zueoyesj	1187	141	their	-PRON-	PRP$
cord-000248-zueoyesj	1187	142	expression	expression	NN
cord-000248-zueoyesj	1187	143	in	in	IN
cord-000248-zueoyesj	1187	144	prostate	prostate	NN
cord-000248-zueoyesj	1187	145	cancer	cancer	NN
cord-000248-zueoyesj	1187	146	A	a	DT
cord-000248-zueoyesj	1187	147	variant	variant	NN
cord-000248-zueoyesj	1187	148	of	of	IN
cord-000248-zueoyesj	1187	149	the	the	DT
cord-000248-zueoyesj	1187	150	alpha	alpha	NN
cord-000248-zueoyesj	1187	151	-	-	HYPH
cord-000248-zueoyesj	1187	152	methyl	methyl	JJ
cord-000248-zueoyesj	1187	153	-	-	HYPH
cord-000248-zueoyesj	1187	154	acyl	acyl	NN
cord-000248-zueoyesj	1187	155	-	-	HYPH
cord-000248-zueoyesj	1187	156	CoA	coa	NN
cord-000248-zueoyesj	1187	157	racemase	racemase	NN
cord-000248-zueoyesj	1187	158	gene	gene	NN
cord-000248-zueoyesj	1187	159	created	create	VBN
cord-000248-zueoyesj	1187	160	by	by	IN
cord-000248-zueoyesj	1187	161	a	a	DT
cord-000248-zueoyesj	1187	162	deletion	deletion	NN
cord-000248-zueoyesj	1187	163	in	in	IN
cord-000248-zueoyesj	1187	164	exon	exon	NN
cord-000248-zueoyesj	1187	165	5	5	CD
cord-000248-zueoyesj	1187	166	and	and	CC
cord-000248-zueoyesj	1187	167	its	-PRON-	PRP$
cord-000248-zueoyesj	1187	168	expression	expression	NN
cord-000248-zueoyesj	1187	169	in	in	IN
cord-000248-zueoyesj	1187	170	prostate	prostate	NN
cord-000248-zueoyesj	1187	171	cancer	cancer	NN
cord-000248-zueoyesj	1187	172	Utility	utility	NN
cord-000248-zueoyesj	1187	173	of	of	IN
cord-000248-zueoyesj	1187	174	alpha	alpha	NN
cord-000248-zueoyesj	1187	175	-	-	HYPH
cord-000248-zueoyesj	1187	176	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1188	1	coenzyme	coenzyme	NNP
cord-000248-zueoyesj	1188	2	A	a	DT
cord-000248-zueoyesj	1188	3	racemase	racemase	NN
cord-000248-zueoyesj	1188	4	(	(	-LRB-
cord-000248-zueoyesj	1188	5	p504s	p504s	CD
cord-000248-zueoyesj	1188	6	antibody	antibody	NN
cord-000248-zueoyesj	1188	7	)	)	-RRB-
cord-000248-zueoyesj	1188	8	as	as	IN
cord-000248-zueoyesj	1188	9	a	a	DT
cord-000248-zueoyesj	1188	10	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1188	11	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1188	12	marker	marker	NN
cord-000248-zueoyesj	1188	13	for	for	IN
cord-000248-zueoyesj	1188	14	cancer	cancer	NN
cord-000248-zueoyesj	1188	15	Alpha	alpha	NN
cord-000248-zueoyesj	1188	16	-	-	HYPH
cord-000248-zueoyesj	1188	17	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1188	18	-	-	HYPH
cord-000248-zueoyesj	1188	19	CoA	coa	NN
cord-000248-zueoyesj	1188	20	racemase	racemase	NN
cord-000248-zueoyesj	1188	21	as	as	IN
cord-000248-zueoyesj	1188	22	a	a	DT
cord-000248-zueoyesj	1188	23	marker	marker	NN
cord-000248-zueoyesj	1188	24	in	in	IN
cord-000248-zueoyesj	1188	25	the	the	DT
cord-000248-zueoyesj	1188	26	differential	differential	JJ
cord-000248-zueoyesj	1188	27	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1188	28	of	of	IN
cord-000248-zueoyesj	1188	29	metanephric	metanephric	JJ
cord-000248-zueoyesj	1188	30	adenoma	adenoma	NN
cord-000248-zueoyesj	1188	31	Frequent	frequent	JJ
cord-000248-zueoyesj	1188	32	overexpression	overexpression	NN
cord-000248-zueoyesj	1188	33	of	of	IN
cord-000248-zueoyesj	1188	34	ETS	ETS	NNP
cord-000248-zueoyesj	1188	35	-	-	HYPH
cord-000248-zueoyesj	1188	36	related	relate	VBN
cord-000248-zueoyesj	1188	37	gene-1	gene-1	NNP
cord-000248-zueoyesj	1189	1	(	(	-LRB-
cord-000248-zueoyesj	1189	2	ERG1	ERG1	NNP
cord-000248-zueoyesj	1189	3	)	)	-RRB-
cord-000248-zueoyesj	1189	4	in	in	IN
cord-000248-zueoyesj	1189	5	prostate	prostate	NN
cord-000248-zueoyesj	1189	6	cancer	cancer	NN
cord-000248-zueoyesj	1189	7	transcriptome	transcriptome	NN
cord-000248-zueoyesj	1189	8	Human	Human	NNP
cord-000248-zueoyesj	1189	9	telomerase	telomerase	NN
cord-000248-zueoyesj	1189	10	and	and	CC
cord-000248-zueoyesj	1190	1	alpha	alpha	JJ
cord-000248-zueoyesj	1190	2	-	-	HYPH
cord-000248-zueoyesj	1190	3	methylacyl	methylacyl	NN
cord-000248-zueoyesj	1190	4	-	-	HYPH
cord-000248-zueoyesj	1190	5	coenzyme	coenzyme	VBZ
cord-000248-zueoyesj	1190	6	A	a	DT
cord-000248-zueoyesj	1190	7	racemase	racemase	NN
cord-000248-zueoyesj	1190	8	in	in	IN
cord-000248-zueoyesj	1190	9	prostatic	prostatic	JJ
cord-000248-zueoyesj	1190	10	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1190	11	.	.	.
cord-000248-zueoyesj	1191	1	A	a	DT
cord-000248-zueoyesj	1191	2	comparative	comparative	JJ
cord-000248-zueoyesj	1191	3	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1191	4	study	study	NN
cord-000248-zueoyesj	1191	5	Prostate	Prostate	NNP
cord-000248-zueoyesj	1191	6	cancer	cancer	NN
cord-000248-zueoyesj	1191	7	detection	detection	NN
cord-000248-zueoyesj	1191	8	on	on	IN
cord-000248-zueoyesj	1191	9	urinalysis	urinalysis	NN
cord-000248-zueoyesj	1191	10	for	for	IN
cord-000248-zueoyesj	1191	11	alpha	alpha	NNP
cord-000248-zueoyesj	1191	12	methylacyl	methylacyl	NNP
cord-000248-zueoyesj	1191	13	coenzyme	coenzyme	NNP
cord-000248-zueoyesj	1192	1	a	a	DT
cord-000248-zueoyesj	1192	2	racemase	racemase	NN
cord-000248-zueoyesj	1192	3	protein	protein	NN
cord-000248-zueoyesj	1192	4	Decreased	decrease	VBD
cord-000248-zueoyesj	1193	1	alpha	alpha	JJ
cord-000248-zueoyesj	1193	2	-	-	HYPH
cord-000248-zueoyesj	1193	3	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1193	4	CoA	coa	NN
cord-000248-zueoyesj	1193	5	racemase	racemase	NN
cord-000248-zueoyesj	1193	6	expression	expression	NN
cord-000248-zueoyesj	1193	7	in	in	IN
cord-000248-zueoyesj	1193	8	localized	localized	JJ
cord-000248-zueoyesj	1193	9	prostate	prostate	NN
cord-000248-zueoyesj	1193	10	cancer	cancer	NN
cord-000248-zueoyesj	1193	11	is	be	VBZ
cord-000248-zueoyesj	1193	12	associated	associate	VBN
cord-000248-zueoyesj	1193	13	with	with	IN
cord-000248-zueoyesj	1193	14	an	an	DT
cord-000248-zueoyesj	1193	15	increased	increase	VBN
cord-000248-zueoyesj	1193	16	rate	rate	NN
cord-000248-zueoyesj	1193	17	of	of	IN
cord-000248-zueoyesj	1193	18	biochemical	biochemical	JJ
cord-000248-zueoyesj	1193	19	recurrence	recurrence	NN
cord-000248-zueoyesj	1193	20	and	and	CC
cord-000248-zueoyesj	1193	21	cancer	cancer	NN
cord-000248-zueoyesj	1193	22	-	-	HYPH
cord-000248-zueoyesj	1193	23	specific	specific	JJ
cord-000248-zueoyesj	1193	24	death	death	NN
cord-000248-zueoyesj	1193	25	Quantitative	quantitative	JJ
cord-000248-zueoyesj	1193	26	determination	determination	NN
cord-000248-zueoyesj	1193	27	of	of	IN
cord-000248-zueoyesj	1193	28	expression	expression	NN
cord-000248-zueoyesj	1193	29	of	of	IN
cord-000248-zueoyesj	1193	30	the	the	DT
cord-000248-zueoyesj	1193	31	prostate	prostate	NN
cord-000248-zueoyesj	1193	32	cancer	cancer	NN
cord-000248-zueoyesj	1193	33	protein	protein	NN
cord-000248-zueoyesj	1193	34	alphamethylacyl	alphamethylacyl	NNP
cord-000248-zueoyesj	1193	35	-	-	HYPH
cord-000248-zueoyesj	1193	36	CoA	coa	NN
cord-000248-zueoyesj	1193	37	racemase	racemase	NN
cord-000248-zueoyesj	1193	38	using	use	VBG
cord-000248-zueoyesj	1193	39	automated	automate	VBN
cord-000248-zueoyesj	1193	40	quantitative	quantitative	JJ
cord-000248-zueoyesj	1193	41	analysis	analysis	NN
cord-000248-zueoyesj	1193	42	(	(	-LRB-
cord-000248-zueoyesj	1193	43	AQUA	AQUA	NNP
cord-000248-zueoyesj	1193	44	)	)	-RRB-
cord-000248-zueoyesj	1193	45	:	:	:
cord-000248-zueoyesj	1193	46	a	a	DT
cord-000248-zueoyesj	1193	47	novel	novel	JJ
cord-000248-zueoyesj	1193	48	paradigm	paradigm	NN
cord-000248-zueoyesj	1193	49	for	for	IN
cord-000248-zueoyesj	1193	50	automated	automated	JJ
cord-000248-zueoyesj	1193	51	and	and	CC
cord-000248-zueoyesj	1193	52	continuous	continuous	JJ
cord-000248-zueoyesj	1193	53	biomarker	biomarker	NN
cord-000248-zueoyesj	1193	54	measurements	measurement	NNS
cord-000248-zueoyesj	1193	55	)	)	-RRB-
cord-000248-zueoyesj	1194	1	alpha	alpha	NN
cord-000248-zueoyesj	1194	2	-	-	HYPH
cord-000248-zueoyesj	1194	3	Methylacyl	Methylacyl	NNP
cord-000248-zueoyesj	1194	4	coenzyme	coenzyme	VBZ
cord-000248-zueoyesj	1194	5	A	a	DT
cord-000248-zueoyesj	1194	6	racemase	racemase	NN
cord-000248-zueoyesj	1194	7	as	as	IN
cord-000248-zueoyesj	1194	8	a	a	DT
cord-000248-zueoyesj	1194	9	tissue	tissue	NN
cord-000248-zueoyesj	1194	10	biomarker	biomarker	NN
cord-000248-zueoyesj	1194	11	for	for	IN
cord-000248-zueoyesj	1194	12	prostate	prostate	NN
cord-000248-zueoyesj	1194	13	cancer	cancer	NN
cord-000248-zueoyesj	1194	14	Prostatic	prostatic	JJ
cord-000248-zueoyesj	1194	15	ductal	ductal	JJ
cord-000248-zueoyesj	1194	16	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1194	17	presenting	present	VBG
cord-000248-zueoyesj	1194	18	as	as	IN
cord-000248-zueoyesj	1194	19	a	a	DT
cord-000248-zueoyesj	1194	20	urethral	urethral	JJ
cord-000248-zueoyesj	1194	21	polyp	polyp	NN
cord-000248-zueoyesj	1194	22	:	:	:
cord-000248-zueoyesj	1194	23	a	a	DT
cord-000248-zueoyesj	1194	24	clinicopathological	clinicopathological	JJ
cord-000248-zueoyesj	1194	25	study	study	NN
cord-000248-zueoyesj	1194	26	of	of	IN
cord-000248-zueoyesj	1194	27	eight	eight	CD
cord-000248-zueoyesj	1194	28	cases	case	NNS
cord-000248-zueoyesj	1194	29	of	of	IN
cord-000248-zueoyesj	1194	30	a	a	DT
cord-000248-zueoyesj	1194	31	lesion	lesion	NN
cord-000248-zueoyesj	1194	32	with	with	IN
cord-000248-zueoyesj	1194	33	the	the	DT
cord-000248-zueoyesj	1194	34	potential	potential	NN
cord-000248-zueoyesj	1194	35	to	to	TO
cord-000248-zueoyesj	1194	36	be	be	VB
cord-000248-zueoyesj	1194	37	misdiagnosed	misdiagnose	VBN
cord-000248-zueoyesj	1194	38	as	as	IN
cord-000248-zueoyesj	1194	39	a	a	DT
cord-000248-zueoyesj	1194	40	benign	benign	JJ
cord-000248-zueoyesj	1194	41	prostatic	prostatic	JJ
cord-000248-zueoyesj	1194	42	urethral	urethral	JJ
cord-000248-zueoyesj	1194	43	polyp	polyp	NN
cord-000248-zueoyesj	1194	44	)	)	-RRB-
cord-000248-zueoyesj	1194	45	alpha	alpha	NN
cord-000248-zueoyesj	1194	46	-	-	HYPH
cord-000248-zueoyesj	1194	47	Methylacyl	Methylacyl	NNP
cord-000248-zueoyesj	1194	48	coenzyme	coenzyme	VBZ
cord-000248-zueoyesj	1194	49	A	a	DT
cord-000248-zueoyesj	1194	50	racemase	racemase	NN
cord-000248-zueoyesj	1194	51	,	,	,
cord-000248-zueoyesj	1194	52	Ki-67	Ki-67	NNP
cord-000248-zueoyesj	1194	53	,	,	,
cord-000248-zueoyesj	1194	54	and	and	CC
cord-000248-zueoyesj	1194	55	topoisomerase	topoisomerase	NN
cord-000248-zueoyesj	1194	56	IIalpha	IIalpha	NNP
cord-000248-zueoyesj	1194	57	in	in	IN
cord-000248-zueoyesj	1194	58	cystoprostatectomies	cystoprostatectomie	NNS
cord-000248-zueoyesj	1194	59	with	with	IN
cord-000248-zueoyesj	1194	60	incidental	incidental	JJ
cord-000248-zueoyesj	1194	61	prostate	prostate	NN
cord-000248-zueoyesj	1194	62	cancer	cancer	NN
cord-000248-zueoyesj	1194	63	Emerging	emerge	VBG
cord-000248-zueoyesj	1194	64	biomarkers	biomarker	NNS
cord-000248-zueoyesj	1194	65	for	for	IN
cord-000248-zueoyesj	1194	66	the	the	DT
cord-000248-zueoyesj	1194	67	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1194	68	and	and	CC
cord-000248-zueoyesj	1194	69	prognosis	prognosis	NN
cord-000248-zueoyesj	1194	70	of	of	IN
cord-000248-zueoyesj	1194	71	prostate	prostate	NN
cord-000248-zueoyesj	1194	72	cancer	cancer	NN
cord-000248-zueoyesj	1194	73	Extraction	extraction	NN
cord-000248-zueoyesj	1194	74	and	and	CC
cord-000248-zueoyesj	1194	75	processing	processing	NN
cord-000248-zueoyesj	1194	76	of	of	IN
cord-000248-zueoyesj	1194	77	high	high	JJ
cord-000248-zueoyesj	1194	78	quality	quality	NN
cord-000248-zueoyesj	1194	79	RNA	RNA	NNP
cord-000248-zueoyesj	1194	80	from	from	IN
cord-000248-zueoyesj	1194	81	impalpable	impalpable	JJ
cord-000248-zueoyesj	1194	82	and	and	CC
cord-000248-zueoyesj	1194	83	macroscopically	macroscopically	RB
cord-000248-zueoyesj	1194	84	invisible	invisible	JJ
cord-000248-zueoyesj	1194	85	prostate	prostate	NN
cord-000248-zueoyesj	1194	86	cancer	cancer	NN
cord-000248-zueoyesj	1194	87	for	for	IN
cord-000248-zueoyesj	1194	88	microarray	microarray	NN
cord-000248-zueoyesj	1194	89	gene	gene	NN
cord-000248-zueoyesj	1194	90	expression	expression	NN
cord-000248-zueoyesj	1194	91	analysis	analysis	NN
cord-000248-zueoyesj	1195	1	Kinetic	kinetic	JJ
cord-000248-zueoyesj	1195	2	fluorescence	fluorescence	NN
cord-000248-zueoyesj	1195	3	reverse	reverse	NN
cord-000248-zueoyesj	1195	4	transcriptase	transcriptase	NN
cord-000248-zueoyesj	1195	5	-	-	HYPH
cord-000248-zueoyesj	1195	6	polymerase	polymerase	NN
cord-000248-zueoyesj	1195	7	chain	chain	NN
cord-000248-zueoyesj	1195	8	reaction	reaction	NN
cord-000248-zueoyesj	1195	9	for	for	IN
cord-000248-zueoyesj	1195	10	alphamethylacyl	alphamethylacyl	NNP
cord-000248-zueoyesj	1195	11	CoA	CoA	NNP
cord-000248-zueoyesj	1195	12	racemase	racemase	NNP
cord-000248-zueoyesj	1196	1	distinguishes	distinguish	VBZ
cord-000248-zueoyesj	1196	2	prostate	prostate	NN
cord-000248-zueoyesj	1196	3	cancer	cancer	NN
cord-000248-zueoyesj	1196	4	from	from	IN
cord-000248-zueoyesj	1196	5	benign	benign	JJ
cord-000248-zueoyesj	1196	6	lesions	lesion	NNS
cord-000248-zueoyesj	1196	7	Expression	expression	NN
cord-000248-zueoyesj	1196	8	profiling	profiling	NN
cord-000248-zueoyesj	1197	1	identifies	identify	VBZ
cord-000248-zueoyesj	1197	2	a	a	DT
cord-000248-zueoyesj	1197	3	novel	novel	JJ
cord-000248-zueoyesj	1197	4	alpha	alpha	NN
cord-000248-zueoyesj	1197	5	-	-	HYPH
cord-000248-zueoyesj	1197	6	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1197	7	-	-	HYPH
cord-000248-zueoyesj	1197	8	CoA	coa	NN
cord-000248-zueoyesj	1197	9	racemase	racemase	NN
cord-000248-zueoyesj	1197	10	exon	exon	NN
cord-000248-zueoyesj	1197	11	with	with	IN
cord-000248-zueoyesj	1197	12	fumarate	fumarate	NNP
cord-000248-zueoyesj	1197	13	hydratase	hydratase	NNP
cord-000248-zueoyesj	1197	14	homology	homology	NN
cord-000248-zueoyesj	1197	15	Alphamethylacyl	Alphamethylacyl	NNP
cord-000248-zueoyesj	1197	16	CoA	coa	NN
cord-000248-zueoyesj	1197	17	racemase	racemase	NN
cord-000248-zueoyesj	1197	18	in	in	IN
cord-000248-zueoyesj	1197	19	pulmonary	pulmonary	JJ
cord-000248-zueoyesj	1197	20	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1197	21	,	,	,
cord-000248-zueoyesj	1197	22	squamous	squamous	JJ
cord-000248-zueoyesj	1197	23	cell	cell	NN
cord-000248-zueoyesj	1197	24	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1197	25	,	,	,
cord-000248-zueoyesj	1197	26	and	and	CC
cord-000248-zueoyesj	1197	27	neuroendocrine	neuroendocrine	JJ
cord-000248-zueoyesj	1197	28	tumors	tumor	NNS
cord-000248-zueoyesj	1197	29	:	:	:
cord-000248-zueoyesj	1197	30	expression	expression	NN
cord-000248-zueoyesj	1197	31	and	and	CC
cord-000248-zueoyesj	1197	32	survival	survival	NN
cord-000248-zueoyesj	1197	33	analysis	analysis	NN
cord-000248-zueoyesj	1197	34	Isolation	isolation	NN
cord-000248-zueoyesj	1197	35	of	of	IN
cord-000248-zueoyesj	1197	36	human	human	JJ
cord-000248-zueoyesj	1197	37	prostatic	prostatic	JJ
cord-000248-zueoyesj	1197	38	epithelial	epithelial	JJ
cord-000248-zueoyesj	1197	39	plasma	plasma	NN
cord-000248-zueoyesj	1197	40	membranes	membrane	NNS
cord-000248-zueoyesj	1197	41	for	for	IN
cord-000248-zueoyesj	1197	42	proteomics	proteomic	NNS
cord-000248-zueoyesj	1197	43	using	use	VBG
cord-000248-zueoyesj	1197	44	mirror	mirror	NN
cord-000248-zueoyesj	1197	45	image	image	NN
cord-000248-zueoyesj	1197	46	tissue	tissue	NN
cord-000248-zueoyesj	1197	47	banking	banking	NN
cord-000248-zueoyesj	1197	48	of	of	IN
cord-000248-zueoyesj	1197	49	radical	radical	JJ
cord-000248-zueoyesj	1197	50	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1197	51	specimens	specimen	NNS
cord-000248-zueoyesj	1197	52	Expression	expression	NN
cord-000248-zueoyesj	1197	53	of	of	IN
cord-000248-zueoyesj	1197	54	alphamethylacyl	alphamethylacyl	JJ
cord-000248-zueoyesj	1197	55	-	-	HYPH
cord-000248-zueoyesj	1197	56	CoA	coa	NN
cord-000248-zueoyesj	1197	57	racemase	racemase	NN
cord-000248-zueoyesj	1197	58	(	(	-LRB-
cord-000248-zueoyesj	1197	59	P504S	P504S	NNP
cord-000248-zueoyesj	1197	60	)	)	-RRB-
cord-000248-zueoyesj	1197	61	in	in	IN
cord-000248-zueoyesj	1197	62	nephrogenic	nephrogenic	JJ
cord-000248-zueoyesj	1197	63	adenoma	adenoma	NN
cord-000248-zueoyesj	1197	64	:	:	:
cord-000248-zueoyesj	1198	1	a	a	DT
cord-000248-zueoyesj	1198	2	significant	significant	JJ
cord-000248-zueoyesj	1198	3	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1198	4	pitfall	pitfall	NN
cord-000248-zueoyesj	1198	5	compounding	compound	VBG
cord-000248-zueoyesj	1198	6	the	the	DT
cord-000248-zueoyesj	1198	7	differential	differential	JJ
cord-000248-zueoyesj	1198	8	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1198	9	with	with	IN
cord-000248-zueoyesj	1198	10	prostatic	prostatic	JJ
cord-000248-zueoyesj	1198	11	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1198	12	Oct4A	oct4a	NN
cord-000248-zueoyesj	1198	13	is	be	VBZ
cord-000248-zueoyesj	1198	14	expressed	express	VBN
cord-000248-zueoyesj	1198	15	by	by	IN
cord-000248-zueoyesj	1198	16	a	a	DT
cord-000248-zueoyesj	1198	17	subpopulation	subpopulation	NN
cord-000248-zueoyesj	1198	18	of	of	IN
cord-000248-zueoyesj	1198	19	prostate	prostate	NN
cord-000248-zueoyesj	1198	20	neuroendocrine	neuroendocrine	JJ
cord-000248-zueoyesj	1198	21	cells	cell	NNS
cord-000248-zueoyesj	1199	1	Humoral	Humoral	NNP
cord-000248-zueoyesj	1199	2	immune	immune	JJ
cord-000248-zueoyesj	1199	3	response	response	NN
cord-000248-zueoyesj	1199	4	to	to	IN
cord-000248-zueoyesj	1199	5	alpha	alpha	JJ
cord-000248-zueoyesj	1199	6	-	-	HYPH
cord-000248-zueoyesj	1199	7	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1199	8	-	-	HYPH
cord-000248-zueoyesj	1199	9	CoA	coa	NN
cord-000248-zueoyesj	1199	10	racemase	racemase	NN
cord-000248-zueoyesj	1199	11	and	and	CC
cord-000248-zueoyesj	1199	12	prostate	prostate	NN
cord-000248-zueoyesj	1199	13	cancer	cancer	NN
cord-000248-zueoyesj	1199	14	Comparison	comparison	NN
cord-000248-zueoyesj	1199	15	of	of	IN
cord-000248-zueoyesj	1199	16	annexin	annexin	NNP
cord-000248-zueoyesj	1199	17	II	II	NNP
cord-000248-zueoyesj	1199	18	,	,	,
cord-000248-zueoyesj	1199	19	p63	p63	NN
cord-000248-zueoyesj	1199	20	and	and	CC
cord-000248-zueoyesj	1199	21	alpha	alpha	NN
cord-000248-zueoyesj	1199	22	-	-	HYPH
cord-000248-zueoyesj	1199	23	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1199	24	-	-	HYPH
cord-000248-zueoyesj	1199	25	CoA	coa	NN
cord-000248-zueoyesj	1199	26	racemase	racemase	NN
cord-000248-zueoyesj	1199	27	immunoreactivity	immunoreactivity	NN
cord-000248-zueoyesj	1199	28	in	in	IN
cord-000248-zueoyesj	1199	29	prostatic	prostatic	JJ
cord-000248-zueoyesj	1199	30	tissue	tissue	NN
cord-000248-zueoyesj	1199	31	:	:	:
cord-000248-zueoyesj	1199	32	a	a	DT
cord-000248-zueoyesj	1199	33	tissue	tissue	NN
cord-000248-zueoyesj	1199	34	microarray	microarray	NN
cord-000248-zueoyesj	1199	35	study	study	NN
cord-000248-zueoyesj	1199	36	Ancillary	ancillary	JJ
cord-000248-zueoyesj	1199	37	alpha	alpha	NN
cord-000248-zueoyesj	1199	38	-	-	HYPH
cord-000248-zueoyesj	1199	39	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1199	40	-	-	HYPH
cord-000248-zueoyesj	1199	41	CoA	coa	NN
cord-000248-zueoyesj	1199	42	racemase	racemase	NN
cord-000248-zueoyesj	1199	43	immunocytochemistry	immunocytochemistry	NN
cord-000248-zueoyesj	1199	44	in	in	IN
cord-000248-zueoyesj	1199	45	the	the	DT
cord-000248-zueoyesj	1199	46	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1199	47	of	of	IN
cord-000248-zueoyesj	1199	48	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1199	49	of	of	IN
cord-000248-zueoyesj	1199	50	the	the	DT
cord-000248-zueoyesj	1199	51	prostate	prostate	NN
cord-000248-zueoyesj	1199	52	in	in	IN
cord-000248-zueoyesj	1199	53	urinary	urinary	JJ
cord-000248-zueoyesj	1199	54	cytology	cytology	NN
cord-000248-zueoyesj	1199	55	:	:	:
cord-000248-zueoyesj	1200	1	a	a	DT
cord-000248-zueoyesj	1200	2	case	case	NN
cord-000248-zueoyesj	1200	3	report	report	NN
cord-000248-zueoyesj	1200	4	Alpha	alpha	NN
cord-000248-zueoyesj	1200	5	-	-	HYPH
cord-000248-zueoyesj	1200	6	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1200	7	-	-	HYPH
cord-000248-zueoyesj	1200	8	CoA	coa	NN
cord-000248-zueoyesj	1200	9	racemase	racemase	NN
cord-000248-zueoyesj	1201	1	(	(	-LRB-
cord-000248-zueoyesj	1201	2	P504S)/34betaE12	P504S)/34betaE12	NNP
cord-000248-zueoyesj	1201	3	/	/	SYM
cord-000248-zueoyesj	1201	4	p63	p63	CD
cord-000248-zueoyesj	1201	5	triple	triple	JJ
cord-000248-zueoyesj	1201	6	cocktail	cocktail	NN
cord-000248-zueoyesj	1201	7	stain	stain	NN
cord-000248-zueoyesj	1201	8	in	in	IN
cord-000248-zueoyesj	1201	9	prostatic	prostatic	JJ
cord-000248-zueoyesj	1201	10	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1201	11	after	after	IN
cord-000248-zueoyesj	1201	12	hormonal	hormonal	JJ
cord-000248-zueoyesj	1201	13	therapy	therapy	NN
cord-000248-zueoyesj	1201	14	Differences	difference	NNS
cord-000248-zueoyesj	1201	15	between	between	IN
cord-000248-zueoyesj	1201	16	latent	latent	JJ
cord-000248-zueoyesj	1201	17	and	and	CC
cord-000248-zueoyesj	1201	18	clinical	clinical	JJ
cord-000248-zueoyesj	1201	19	prostate	prostate	NN
cord-000248-zueoyesj	1201	20	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1201	21	:	:	:
cord-000248-zueoyesj	1202	1	lower	low	JJR
cord-000248-zueoyesj	1202	2	cell	cell	NN
cord-000248-zueoyesj	1202	3	proliferation	proliferation	NN
cord-000248-zueoyesj	1202	4	activity	activity	NN
cord-000248-zueoyesj	1202	5	in	in	IN
cord-000248-zueoyesj	1202	6	latent	latent	JJ
cord-000248-zueoyesj	1202	7	cases	case	NNS
cord-000248-zueoyesj	1202	8	Variation	variation	NN
cord-000248-zueoyesj	1202	9	of	of	IN
cord-000248-zueoyesj	1202	10	alpha	alpha	JJ
cord-000248-zueoyesj	1202	11	-	-	HYPH
cord-000248-zueoyesj	1202	12	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1202	13	-	-	HYPH
cord-000248-zueoyesj	1202	14	CoA	coa	NN
cord-000248-zueoyesj	1202	15	racemase	racemase	NN
cord-000248-zueoyesj	1202	16	expression	expression	NN
cord-000248-zueoyesj	1202	17	in	in	IN
cord-000248-zueoyesj	1202	18	prostate	prostate	NN
cord-000248-zueoyesj	1202	19	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1202	20	cases	case	NNS
cord-000248-zueoyesj	1202	21	receiving	receive	VBG
cord-000248-zueoyesj	1202	22	hormonal	hormonal	JJ
cord-000248-zueoyesj	1202	23	therapy	therapy	NN
cord-000248-zueoyesj	1202	24	Phytanic	Phytanic	NNP
cord-000248-zueoyesj	1202	25	acid	acid	NN
cord-000248-zueoyesj	1202	26	,	,	,
cord-000248-zueoyesj	1202	27	AMACR	AMACR	NNP
cord-000248-zueoyesj	1202	28	and	and	CC
cord-000248-zueoyesj	1202	29	prostate	prostate	NN
cord-000248-zueoyesj	1203	1	cancer	cancer	NN
cord-000248-zueoyesj	1203	2	risk	risk	NN
cord-000248-zueoyesj	1204	1	Transcriptome	Transcriptome	NNP
cord-000248-zueoyesj	1204	2	analysis	analysis	NN
cord-000248-zueoyesj	1204	3	of	of	IN
cord-000248-zueoyesj	1204	4	human	human	JJ
cord-000248-zueoyesj	1204	5	colon	colon	NN
cord-000248-zueoyesj	1204	6	Caco-2	caco-2	NN
cord-000248-zueoyesj	1204	7	cells	cell	NNS
cord-000248-zueoyesj	1204	8	exposed	expose	VBN
cord-000248-zueoyesj	1204	9	to	to	IN
cord-000248-zueoyesj	1204	10	sulforaphane	sulforaphane	NNP
cord-000248-zueoyesj	1204	11	Expression	Expression	NNP
cord-000248-zueoyesj	1204	12	of	of	IN
cord-000248-zueoyesj	1204	13	alpha	alpha	JJ
cord-000248-zueoyesj	1204	14	-	-	HYPH
cord-000248-zueoyesj	1204	15	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1204	16	-	-	HYPH
cord-000248-zueoyesj	1204	17	CoA	coa	NN
cord-000248-zueoyesj	1204	18	racemase	racemase	NN
cord-000248-zueoyesj	1204	19	in	in	IN
cord-000248-zueoyesj	1204	20	papillary	papillary	JJ
cord-000248-zueoyesj	1204	21	renal	renal	JJ
cord-000248-zueoyesj	1204	22	cell	cell	NN
cord-000248-zueoyesj	1204	23	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1204	24	Alpha	Alpha	NNP
cord-000248-zueoyesj	1204	25	-	-	HYPH
cord-000248-zueoyesj	1204	26	Methylacyl	Methylacyl	NNP
cord-000248-zueoyesj	1204	27	-	-	HYPH
cord-000248-zueoyesj	1204	28	CoA	CoA	NNP
cord-000248-zueoyesj	1204	29	Racemase	Racemase	NNP
cord-000248-zueoyesj	1204	30	Expression	Expression	NNP
cord-000248-zueoyesj	1204	31	is	be	VBZ
cord-000248-zueoyesj	1204	32	Upregulated	upregulate	VBN
cord-000248-zueoyesj	1204	33	in	in	IN
cord-000248-zueoyesj	1204	34	Gastric	Gastric	NNP
cord-000248-zueoyesj	1204	35	Adenocarcinoma	Adenocarcinoma	NNP
cord-000248-zueoyesj	1204	36	:	:	:
cord-000248-zueoyesj	1205	1	A	a	DT
cord-000248-zueoyesj	1205	2	Study	Study	NNP
cord-000248-zueoyesj	1205	3	of	of	IN
cord-000248-zueoyesj	1205	4	249	249	CD
cord-000248-zueoyesj	1205	5	Cases	case	NNS
cord-000248-zueoyesj	1205	6	Sensitivity	sensitivity	NN
cord-000248-zueoyesj	1205	7	of	of	IN
cord-000248-zueoyesj	1205	8	P504S	P504S	NNP
cord-000248-zueoyesj	1205	9	/	/	SYM
cord-000248-zueoyesj	1205	10	alpha	alpha	JJ
cord-000248-zueoyesj	1205	11	-	-	HYPH
cord-000248-zueoyesj	1205	12	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1205	13	-	-	HYPH
cord-000248-zueoyesj	1205	14	CoA	coa	NN
cord-000248-zueoyesj	1205	15	racemase	racemase	NN
cord-000248-zueoyesj	1205	16	(	(	-LRB-
cord-000248-zueoyesj	1205	17	AMACR	AMACR	NNP
cord-000248-zueoyesj	1205	18	)	)	-RRB-
cord-000248-zueoyesj	1205	19	immunohistochemistry	immunohistochemistry	NN
cord-000248-zueoyesj	1205	20	for	for	IN
cord-000248-zueoyesj	1205	21	the	the	DT
cord-000248-zueoyesj	1205	22	detection	detection	NN
cord-000248-zueoyesj	1205	23	of	of	IN
cord-000248-zueoyesj	1205	24	prostate	prostate	NN
cord-000248-zueoyesj	1205	25	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1205	26	on	on	IN
cord-000248-zueoyesj	1205	27	stored	store	VBN
cord-000248-zueoyesj	1205	28	needle	needle	NN
cord-000248-zueoyesj	1205	29	biopsies	biopsy	NNS
cord-000248-zueoyesj	1205	30	Diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1205	31	utility	utility	NN
cord-000248-zueoyesj	1205	32	of	of	IN
cord-000248-zueoyesj	1205	33	immunohistochemistry	immunohistochemistry	NN
cord-000248-zueoyesj	1205	34	in	in	IN
cord-000248-zueoyesj	1205	35	morphologically	morphologically	RB
cord-000248-zueoyesj	1205	36	difficult	difficult	JJ
cord-000248-zueoyesj	1205	37	prostate	prostate	NN
cord-000248-zueoyesj	1205	38	cancer	cancer	NN
cord-000248-zueoyesj	1205	39	:	:	:
cord-000248-zueoyesj	1205	40	review	review	NN
cord-000248-zueoyesj	1205	41	of	of	IN
cord-000248-zueoyesj	1205	42	current	current	JJ
cord-000248-zueoyesj	1205	43	literature	literature	NN
cord-000248-zueoyesj	1206	1	The	the	DT
cord-000248-zueoyesj	1206	2	prostate	prostate	NN
cord-000248-zueoyesj	1206	3	-	-	HYPH
cord-000248-zueoyesj	1206	4	specific	specific	JJ
cord-000248-zueoyesj	1206	5	G	g	NN
cord-000248-zueoyesj	1206	6	-	-	HYPH
cord-000248-zueoyesj	1206	7	protein	protein	NN
cord-000248-zueoyesj	1206	8	coupled	coupled	JJ
cord-000248-zueoyesj	1206	9	receptors	receptor	NNS
cord-000248-zueoyesj	1206	10	PSGR	PSGR	NNP
cord-000248-zueoyesj	1206	11	and	and	CC
cord-000248-zueoyesj	1206	12	PSGR2	PSGR2	NNS
cord-000248-zueoyesj	1206	13	are	be	VBP
cord-000248-zueoyesj	1206	14	prostate	prostate	NN
cord-000248-zueoyesj	1206	15	cancer	cancer	NN
cord-000248-zueoyesj	1206	16	biomarkers	biomarker	NNS
cord-000248-zueoyesj	1206	17	that	that	WDT
cord-000248-zueoyesj	1206	18	are	be	VBP
cord-000248-zueoyesj	1206	19	complementary	complementary	JJ
cord-000248-zueoyesj	1206	20	to	to	IN
cord-000248-zueoyesj	1206	21	alpha	alpha	JJ
cord-000248-zueoyesj	1206	22	-	-	HYPH
cord-000248-zueoyesj	1206	23	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1206	24	-	-	HYPH
cord-000248-zueoyesj	1206	25	CoA	coa	NN
cord-000248-zueoyesj	1206	26	racemase	racemase	NN
cord-000248-zueoyesj	1206	27	Partial	partial	JJ
cord-000248-zueoyesj	1206	28	atrophy	atrophy	NN
cord-000248-zueoyesj	1206	29	on	on	IN
cord-000248-zueoyesj	1206	30	prostate	prostate	NN
cord-000248-zueoyesj	1206	31	needle	needle	NN
cord-000248-zueoyesj	1206	32	biopsy	biopsy	NN
cord-000248-zueoyesj	1206	33	cores	core	NNS
cord-000248-zueoyesj	1206	34	:	:	:
cord-000248-zueoyesj	1207	1	a	a	DT
cord-000248-zueoyesj	1207	2	morphologic	morphologic	JJ
cord-000248-zueoyesj	1207	3	and	and	CC
cord-000248-zueoyesj	1207	4	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1207	5	study	study	NN
cord-000248-zueoyesj	1207	6	Abundant	abundant	JJ
cord-000248-zueoyesj	1207	7	expression	expression	NN
cord-000248-zueoyesj	1207	8	of	of	IN
cord-000248-zueoyesj	1207	9	AMACR	AMACR	NNP
cord-000248-zueoyesj	1207	10	in	in	IN
cord-000248-zueoyesj	1207	11	many	many	JJ
cord-000248-zueoyesj	1207	12	distinct	distinct	JJ
cord-000248-zueoyesj	1207	13	tumour	tumour	NN
cord-000248-zueoyesj	1207	14	types	type	NNS
cord-000248-zueoyesj	1207	15	Peroxisomal	Peroxisomal	NNP
cord-000248-zueoyesj	1207	16	disorders	disorder	NNS
cord-000248-zueoyesj	1207	17	affecting	affect	VBG
cord-000248-zueoyesj	1207	18	phytanic	phytanic	NNP
cord-000248-zueoyesj	1207	19	acid	acid	NN
cord-000248-zueoyesj	1207	20	alphaoxidation	alphaoxidation	NN
cord-000248-zueoyesj	1207	21	:	:	:
cord-000248-zueoyesj	1207	22	a	a	DT
cord-000248-zueoyesj	1207	23	review	review	NN
cord-000248-zueoyesj	1207	24	Alpha	alpha	NN
cord-000248-zueoyesj	1207	25	-	-	HYPH
cord-000248-zueoyesj	1207	26	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1207	27	-	-	HYPH
cord-000248-zueoyesj	1207	28	CoA	coa	NN
cord-000248-zueoyesj	1207	29	racemase	racemase	NN
cord-000248-zueoyesj	1207	30	protein	protein	NN
cord-000248-zueoyesj	1207	31	expression	expression	NN
cord-000248-zueoyesj	1207	32	is	be	VBZ
cord-000248-zueoyesj	1207	33	associated	associate	VBN
cord-000248-zueoyesj	1207	34	with	with	IN
cord-000248-zueoyesj	1207	35	the	the	DT
cord-000248-zueoyesj	1207	36	degree	degree	NN
cord-000248-zueoyesj	1207	37	of	of	IN
cord-000248-zueoyesj	1207	38	differentiation	differentiation	NN
cord-000248-zueoyesj	1207	39	in	in	IN
cord-000248-zueoyesj	1207	40	breast	breast	NN
cord-000248-zueoyesj	1207	41	cancer	cancer	NN
cord-000248-zueoyesj	1207	42	using	use	VBG
cord-000248-zueoyesj	1207	43	quantitative	quantitative	JJ
cord-000248-zueoyesj	1207	44	image	image	NN
cord-000248-zueoyesj	1207	45	analysis	analysis	NN
cord-000248-zueoyesj	1207	46	Analysis	Analysis	NNP
cord-000248-zueoyesj	1207	47	of	of	IN
cord-000248-zueoyesj	1207	48	alpha	alpha	JJ
cord-000248-zueoyesj	1207	49	-	-	HYPH
cord-000248-zueoyesj	1207	50	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1207	51	-	-	HYPH
cord-000248-zueoyesj	1207	52	CoA	coa	NN
cord-000248-zueoyesj	1207	53	racemase	racemase	NN
cord-000248-zueoyesj	1207	54	(	(	-LRB-
cord-000248-zueoyesj	1207	55	P504S	P504S	NNP
cord-000248-zueoyesj	1207	56	)	)	-RRB-
cord-000248-zueoyesj	1207	57	expression	expression	NN
cord-000248-zueoyesj	1207	58	in	in	IN
cord-000248-zueoyesj	1207	59	high	high	JJ
cord-000248-zueoyesj	1207	60	-	-	HYPH
cord-000248-zueoyesj	1207	61	grade	grade	NN
cord-000248-zueoyesj	1207	62	prostatic	prostatic	JJ
cord-000248-zueoyesj	1207	63	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	1207	64	neoplasia	neoplasia	NN
cord-000248-zueoyesj	1207	65	Serum	serum	NN
cord-000248-zueoyesj	1207	66	levels	level	NNS
cord-000248-zueoyesj	1207	67	of	of	IN
cord-000248-zueoyesj	1207	68	phytanic	phytanic	NN
cord-000248-zueoyesj	1207	69	acid	acid	NN
cord-000248-zueoyesj	1207	70	are	be	VBP
cord-000248-zueoyesj	1207	71	associated	associate	VBN
cord-000248-zueoyesj	1207	72	with	with	IN
cord-000248-zueoyesj	1208	1	prostate	prostate	NN
cord-000248-zueoyesj	1208	2	cancer	cancer	NN
cord-000248-zueoyesj	1208	3	risk	risk	NN
cord-000248-zueoyesj	1208	4	Detection	Detection	NNP
cord-000248-zueoyesj	1208	5	of	of	IN
cord-000248-zueoyesj	1208	6	alpha	alpha	JJ
cord-000248-zueoyesj	1208	7	-	-	HYPH
cord-000248-zueoyesj	1208	8	methylacyl	methylacyl	NN
cord-000248-zueoyesj	1208	9	-	-	HYPH
cord-000248-zueoyesj	1208	10	coenzyme	coenzyme	VBZ
cord-000248-zueoyesj	1208	11	A	a	DT
cord-000248-zueoyesj	1208	12	racemase	racemase	NN
cord-000248-zueoyesj	1208	13	in	in	IN
cord-000248-zueoyesj	1208	14	postradiation	postradiation	NN
cord-000248-zueoyesj	1208	15	prostatic	prostatic	JJ
cord-000248-zueoyesj	1208	16	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1208	17	Tumor	tumor	NN
cord-000248-zueoyesj	1208	18	suppressor	suppressor	NN
cord-000248-zueoyesj	1208	19	activity	activity	NN
cord-000248-zueoyesj	1208	20	of	of	IN
cord-000248-zueoyesj	1208	21	glucocorticoid	glucocorticoid	NN
cord-000248-zueoyesj	1208	22	receptor	receptor	NN
cord-000248-zueoyesj	1208	23	in	in	IN
cord-000248-zueoyesj	1208	24	the	the	DT
cord-000248-zueoyesj	1208	25	prostate	prostate	NN
cord-000248-zueoyesj	1208	26	Detection	detection	NN
cord-000248-zueoyesj	1208	27	of	of	IN
cord-000248-zueoyesj	1208	28	alpha	alpha	JJ
cord-000248-zueoyesj	1208	29	-	-	HYPH
cord-000248-zueoyesj	1208	30	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1208	31	-	-	HYPH
cord-000248-zueoyesj	1208	32	coenzyme	coenzyme	NN
cord-000248-zueoyesj	1208	33	-	-	HYPH
cord-000248-zueoyesj	1208	34	A	a	NN
cord-000248-zueoyesj	1208	35	racemase	racemase	NN
cord-000248-zueoyesj	1208	36	transcripts	transcript	NNS
cord-000248-zueoyesj	1208	37	in	in	IN
cord-000248-zueoyesj	1208	38	blood	blood	NN
cord-000248-zueoyesj	1208	39	and	and	CC
cord-000248-zueoyesj	1208	40	urine	urine	NN
cord-000248-zueoyesj	1208	41	samples	sample	NNS
cord-000248-zueoyesj	1208	42	of	of	IN
cord-000248-zueoyesj	1208	43	prostate	prostate	NN
cord-000248-zueoyesj	1208	44	cancer	cancer	NN
cord-000248-zueoyesj	1208	45	patients	patient	NNS
cord-000248-zueoyesj	1208	46	Alphamethylacyl	Alphamethylacyl	NNP
cord-000248-zueoyesj	1208	47	-	-	HYPH
cord-000248-zueoyesj	1208	48	CoA	coa	NN
cord-000248-zueoyesj	1208	49	racemase	racemase	NN
cord-000248-zueoyesj	1208	50	as	as	IN
cord-000248-zueoyesj	1208	51	an	an	DT
cord-000248-zueoyesj	1208	52	androgen	androgen	NN
cord-000248-zueoyesj	1208	53	-	-	HYPH
cord-000248-zueoyesj	1208	54	independent	independent	JJ
cord-000248-zueoyesj	1208	55	growth	growth	NN
cord-000248-zueoyesj	1208	56	modifier	modifier	NN
cord-000248-zueoyesj	1208	57	in	in	IN
cord-000248-zueoyesj	1208	58	prostate	prostate	NN
cord-000248-zueoyesj	1208	59	cancer	cancer	NN
cord-000248-zueoyesj	1208	60	Peroxisomal	Peroxisomal	NNP
cord-000248-zueoyesj	1208	61	branched	branch	VBD
cord-000248-zueoyesj	1208	62	chain	chain	NN
cord-000248-zueoyesj	1208	63	fatty	fatty	JJ
cord-000248-zueoyesj	1208	64	acid	acid	NN
cord-000248-zueoyesj	1208	65	beta	beta	NN
cord-000248-zueoyesj	1208	66	-	-	HYPH
cord-000248-zueoyesj	1208	67	oxidation	oxidation	NN
cord-000248-zueoyesj	1208	68	pathway	pathway	NN
cord-000248-zueoyesj	1208	69	is	be	VBZ
cord-000248-zueoyesj	1208	70	upregulated	upregulate	VBN
cord-000248-zueoyesj	1208	71	in	in	IN
cord-000248-zueoyesj	1208	72	prostate	prostate	NN
cord-000248-zueoyesj	1208	73	cancer	cancer	NN
cord-000248-zueoyesj	1208	74	A	a	NN
cord-000248-zueoyesj	1209	1	nonclassic	nonclassic	NNP
cord-000248-zueoyesj	1209	2	CCAAT	CCAAT	NNP
cord-000248-zueoyesj	1209	3	enhancer	enhancer	NN
cord-000248-zueoyesj	1209	4	element	element	NN
cord-000248-zueoyesj	1209	5	binding	bind	VBG
cord-000248-zueoyesj	1209	6	protein	protein	NN
cord-000248-zueoyesj	1209	7	binding	bind	VBG
cord-000248-zueoyesj	1209	8	site	site	NN
cord-000248-zueoyesj	1209	9	contributes	contribute	VBZ
cord-000248-zueoyesj	1209	10	to	to	IN
cord-000248-zueoyesj	1209	11	alpha	alpha	NN
cord-000248-zueoyesj	1209	12	-	-	HYPH
cord-000248-zueoyesj	1209	13	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1209	14	-	-	HYPH
cord-000248-zueoyesj	1209	15	CoA	coa	NN
cord-000248-zueoyesj	1209	16	racemase	racemase	NN
cord-000248-zueoyesj	1209	17	expression	expression	NN
cord-000248-zueoyesj	1209	18	in	in	IN
cord-000248-zueoyesj	1209	19	prostate	prostate	NN
cord-000248-zueoyesj	1209	20	cancer	cancer	NN
cord-000248-zueoyesj	1209	21	Sequence	sequence	NN
cord-000248-zueoyesj	1209	22	variants	variant	NNS
cord-000248-zueoyesj	1209	23	of	of	IN
cord-000248-zueoyesj	1209	24	alpha	alpha	JJ
cord-000248-zueoyesj	1209	25	-	-	HYPH
cord-000248-zueoyesj	1209	26	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1209	27	-	-	HYPH
cord-000248-zueoyesj	1209	28	CoA	coa	NN
cord-000248-zueoyesj	1209	29	racemase	racemase	NN
cord-000248-zueoyesj	1209	30	are	be	VBP
cord-000248-zueoyesj	1209	31	associated	associate	VBN
cord-000248-zueoyesj	1209	32	with	with	IN
cord-000248-zueoyesj	1209	33	prostate	prostate	NN
cord-000248-zueoyesj	1209	34	cancer	cancer	NN
cord-000248-zueoyesj	1209	35	risk	risk	NN
cord-000248-zueoyesj	1209	36	How	how	WRB
cord-000248-zueoyesj	1209	37	often	often	RB
cord-000248-zueoyesj	1209	38	does	do	VBZ
cord-000248-zueoyesj	1209	39	alphamethylacyl	alphamethylacyl	JJ
cord-000248-zueoyesj	1209	40	-	-	HYPH
cord-000248-zueoyesj	1209	41	CoA	coa	NN
cord-000248-zueoyesj	1209	42	-	-	HYPH
cord-000248-zueoyesj	1209	43	racemase	racemase	NN
cord-000248-zueoyesj	1209	44	contribute	contribute	NN
cord-000248-zueoyesj	1209	45	to	to	IN
cord-000248-zueoyesj	1209	46	resolving	resolve	VBG
cord-000248-zueoyesj	1209	47	an	an	DT
cord-000248-zueoyesj	1209	48	atypical	atypical	JJ
cord-000248-zueoyesj	1209	49	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1209	50	on	on	IN
cord-000248-zueoyesj	1209	51	prostate	prostate	NN
cord-000248-zueoyesj	1209	52	needle	needle	NN
cord-000248-zueoyesj	1209	53	biopsy	biopsy	NN
cord-000248-zueoyesj	1209	54	beyond	beyond	IN
cord-000248-zueoyesj	1209	55	that	that	DT
cord-000248-zueoyesj	1209	56	provided	provide	VBN
cord-000248-zueoyesj	1209	57	by	by	IN
cord-000248-zueoyesj	1209	58	basal	basal	NN
cord-000248-zueoyesj	1209	59	cell	cell	NN
cord-000248-zueoyesj	1209	60	markers	marker	NNS
cord-000248-zueoyesj	1209	61	?	?	.
cord-000248-zueoyesj	1210	1	Alpha	Alpha	NNP
cord-000248-zueoyesj	1210	2	-	-	HYPH
cord-000248-zueoyesj	1210	3	Methylacyl	Methylacyl	NNP
cord-000248-zueoyesj	1210	4	-	-	HYPH
cord-000248-zueoyesj	1210	5	CoA	CoA	NNP
cord-000248-zueoyesj	1210	6	racemase	racemase	NN
cord-000248-zueoyesj	1210	7	:	:	:
cord-000248-zueoyesj	1210	8	a	a	DT
cord-000248-zueoyesj	1210	9	novel	novel	JJ
cord-000248-zueoyesj	1210	10	tumor	tumor	NN
cord-000248-zueoyesj	1210	11	marker	marker	NN
cord-000248-zueoyesj	1210	12	over	over	RB
cord-000248-zueoyesj	1210	13	-	-	HYPH
cord-000248-zueoyesj	1210	14	expressed	express	VBN
cord-000248-zueoyesj	1210	15	in	in	IN
cord-000248-zueoyesj	1210	16	several	several	JJ
cord-000248-zueoyesj	1210	17	human	human	JJ
cord-000248-zueoyesj	1210	18	cancers	cancer	NNS
cord-000248-zueoyesj	1210	19	and	and	CC
cord-000248-zueoyesj	1210	20	their	-PRON-	PRP$
cord-000248-zueoyesj	1210	21	precursor	precursor	NN
cord-000248-zueoyesj	1210	22	lesions	lesion	NNS
cord-000248-zueoyesj	1210	23	Expression	expression	NN
cord-000248-zueoyesj	1210	24	and	and	CC
cord-000248-zueoyesj	1210	25	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1210	26	utility	utility	NN
cord-000248-zueoyesj	1210	27	of	of	IN
cord-000248-zueoyesj	1210	28	alphamethylacyl	alphamethylacyl	JJ
cord-000248-zueoyesj	1210	29	-	-	HYPH
cord-000248-zueoyesj	1210	30	CoA	coa	NN
cord-000248-zueoyesj	1210	31	-	-	HYPH
cord-000248-zueoyesj	1210	32	racemase	racemase	NNP
cord-000248-zueoyesj	1210	33	(	(	-LRB-
cord-000248-zueoyesj	1210	34	P504S	P504S	NNP
cord-000248-zueoyesj	1210	35	)	)	-RRB-
cord-000248-zueoyesj	1210	36	in	in	IN
cord-000248-zueoyesj	1210	37	foamy	foamy	JJ
cord-000248-zueoyesj	1210	38	gland	gland	NN
cord-000248-zueoyesj	1210	39	and	and	CC
cord-000248-zueoyesj	1210	40	pseudohyperplastic	pseudohyperplastic	JJ
cord-000248-zueoyesj	1210	41	prostate	prostate	NN
cord-000248-zueoyesj	1211	1	cancer	cancer	NN
cord-000248-zueoyesj	1211	2	A	a	DT
cord-000248-zueoyesj	1211	3	novel	novel	JJ
cord-000248-zueoyesj	1211	4	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1211	5	test	test	NN
cord-000248-zueoyesj	1211	6	for	for	IN
cord-000248-zueoyesj	1211	7	prostate	prostate	NN
cord-000248-zueoyesj	1211	8	cancer	cancer	NN
cord-000248-zueoyesj	1211	9	emerges	emerge	VBZ
cord-000248-zueoyesj	1211	10	from	from	IN
cord-000248-zueoyesj	1211	11	the	the	DT
cord-000248-zueoyesj	1211	12	determination	determination	NN
cord-000248-zueoyesj	1211	13	of	of	IN
cord-000248-zueoyesj	1211	14	alphamethylacyl	alphamethylacyl	NNP
cord-000248-zueoyesj	1211	15	-	-	HYPH
cord-000248-zueoyesj	1211	16	coenzyme	coenzyme	VBZ
cord-000248-zueoyesj	1211	17	a	a	DT
cord-000248-zueoyesj	1211	18	racemase	racemase	NN
cord-000248-zueoyesj	1211	19	in	in	IN
cord-000248-zueoyesj	1211	20	prostatic	prostatic	JJ
cord-000248-zueoyesj	1211	21	secretions	secretion	NNS
cord-000248-zueoyesj	1211	22	Deletion	deletion	NN
cord-000248-zueoyesj	1211	23	hotspots	hotspot	NNS
cord-000248-zueoyesj	1211	24	in	in	IN
cord-000248-zueoyesj	1211	25	AMACR	AMACR	NNP
cord-000248-zueoyesj	1211	26	promoter	promoter	NN
cord-000248-zueoyesj	1211	27	CpG	CpG	NNP
cord-000248-zueoyesj	1211	28	island	island	NNP
cord-000248-zueoyesj	1211	29	are	be	VBP
cord-000248-zueoyesj	1211	30	cis	cis	NNP
cord-000248-zueoyesj	1211	31	-	-	JJ
cord-000248-zueoyesj	1211	32	regulatory	regulatory	JJ
cord-000248-zueoyesj	1211	33	elements	element	NNS
cord-000248-zueoyesj	1211	34	controlling	control	VBG
cord-000248-zueoyesj	1211	35	the	the	DT
cord-000248-zueoyesj	1211	36	gene	gene	NN
cord-000248-zueoyesj	1211	37	expression	expression	NN
cord-000248-zueoyesj	1211	38	in	in	IN
cord-000248-zueoyesj	1211	39	the	the	DT
cord-000248-zueoyesj	1211	40	colon	colon	NN
cord-000248-zueoyesj	1211	41	Gene	Gene	NNP
cord-000248-zueoyesj	1211	42	expression	expression	NN
cord-000248-zueoyesj	1211	43	profiles	profile	NNS
cord-000248-zueoyesj	1211	44	in	in	IN
cord-000248-zueoyesj	1211	45	the	the	DT
cord-000248-zueoyesj	1211	46	PC-3	PC-3	NNP
cord-000248-zueoyesj	1211	47	human	human	JJ
cord-000248-zueoyesj	1211	48	prostate	prostate	NN
cord-000248-zueoyesj	1211	49	cancer	cancer	NN
cord-000248-zueoyesj	1211	50	cells	cell	NNS
cord-000248-zueoyesj	1211	51	induced	induce	VBN
cord-000248-zueoyesj	1211	52	by	by	IN
cord-000248-zueoyesj	1211	53	NKX3.1	NKX3.1	NNP
cord-000248-zueoyesj	1211	54	Usefulness	Usefulness	NNP
cord-000248-zueoyesj	1211	55	of	of	IN
cord-000248-zueoyesj	1211	56	cytokeratin	cytokeratin	NNP
cord-000248-zueoyesj	1211	57	5/6	5/6	CD
cord-000248-zueoyesj	1211	58	and	and	CC
cord-000248-zueoyesj	1211	59	AMACR	AMACR	NNP
cord-000248-zueoyesj	1211	60	applied	apply	VBD
cord-000248-zueoyesj	1211	61	as	as	IN
cord-000248-zueoyesj	1211	62	double	double	JJ
cord-000248-zueoyesj	1211	63	sequential	sequential	JJ
cord-000248-zueoyesj	1211	64	immunostains	immunostain	NNS
cord-000248-zueoyesj	1211	65	for	for	IN
cord-000248-zueoyesj	1211	66	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1211	67	assessment	assessment	NN
cord-000248-zueoyesj	1211	68	of	of	IN
cord-000248-zueoyesj	1211	69	problematic	problematic	JJ
cord-000248-zueoyesj	1211	70	prostate	prostate	NN
cord-000248-zueoyesj	1211	71	specimens	specimen	NNS
cord-000248-zueoyesj	1211	72	Conversion	Conversion	NNP
cord-000248-zueoyesj	1211	73	of	of	IN
cord-000248-zueoyesj	1211	74	prostate	prostate	NN
cord-000248-zueoyesj	1211	75	cancer	cancer	NN
cord-000248-zueoyesj	1211	76	from	from	IN
cord-000248-zueoyesj	1211	77	hormone	hormone	NN
cord-000248-zueoyesj	1211	78	independency	independency	NN
cord-000248-zueoyesj	1211	79	to	to	IN
cord-000248-zueoyesj	1211	80	dependency	dependency	NN
cord-000248-zueoyesj	1211	81	due	due	IN
cord-000248-zueoyesj	1211	82	to	to	IN
cord-000248-zueoyesj	1211	83	AMACR	AMACR	NNP
cord-000248-zueoyesj	1211	84	inhibition	inhibition	NN
cord-000248-zueoyesj	1211	85	:	:	:
cord-000248-zueoyesj	1211	86	involvement	involvement	NN
cord-000248-zueoyesj	1211	87	of	of	IN
cord-000248-zueoyesj	1211	88	increased	increase	VBN
cord-000248-zueoyesj	1211	89	AR	AR	NNP
cord-000248-zueoyesj	1211	90	expression	expression	NN
cord-000248-zueoyesj	1211	91	and	and	CC
cord-000248-zueoyesj	1211	92	decreased	decrease	VBD
cord-000248-zueoyesj	1211	93	IGF1	IGF1	NNP
cord-000248-zueoyesj	1211	94	expression	expression	NN
cord-000248-zueoyesj	1211	95	Oct4A	oct4a	NN
cord-000248-zueoyesj	1211	96	is	be	VBZ
cord-000248-zueoyesj	1211	97	expressed	express	VBN
cord-000248-zueoyesj	1211	98	by	by	IN
cord-000248-zueoyesj	1211	99	a	a	DT
cord-000248-zueoyesj	1211	100	subpopulation	subpopulation	NN
cord-000248-zueoyesj	1211	101	of	of	IN
cord-000248-zueoyesj	1211	102	prostate	prostate	NN
cord-000248-zueoyesj	1211	103	neuroendocrine	neuroendocrine	JJ
cord-000248-zueoyesj	1211	104	cells	cell	NNS
cord-000248-zueoyesj	1212	1	A	a	DT
cord-000248-zueoyesj	1212	2	duplex	duplex	JJ
cord-000248-zueoyesj	1212	3	quantitative	quantitative	JJ
cord-000248-zueoyesj	1212	4	polymerase	polymerase	NN
cord-000248-zueoyesj	1212	5	chain	chain	NN
cord-000248-zueoyesj	1212	6	reaction	reaction	NN
cord-000248-zueoyesj	1212	7	assay	assay	NN
cord-000248-zueoyesj	1212	8	based	base	VBN
cord-000248-zueoyesj	1212	9	on	on	IN
cord-000248-zueoyesj	1212	10	quantification	quantification	NN
cord-000248-zueoyesj	1212	11	of	of	IN
cord-000248-zueoyesj	1212	12	alphamethylacyl	alphamethylacyl	NNP
cord-000248-zueoyesj	1212	13	-	-	HYPH
cord-000248-zueoyesj	1212	14	CoA	coa	NN
cord-000248-zueoyesj	1212	15	racemase	racemase	NN
cord-000248-zueoyesj	1212	16	transcripts	transcript	NNS
cord-000248-zueoyesj	1212	17	and	and	CC
cord-000248-zueoyesj	1212	18	prostate	prostate	NN
cord-000248-zueoyesj	1212	19	cancer	cancer	NN
cord-000248-zueoyesj	1212	20	antigen	antigen	NN
cord-000248-zueoyesj	1212	21	3	3	CD
cord-000248-zueoyesj	1212	22	in	in	IN
cord-000248-zueoyesj	1212	23	urine	urine	NN
cord-000248-zueoyesj	1212	24	sediments	sediment	NNS
cord-000248-zueoyesj	1212	25	improved	improve	VBD
cord-000248-zueoyesj	1212	26	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1212	27	accuracy	accuracy	NN
cord-000248-zueoyesj	1212	28	for	for	IN
cord-000248-zueoyesj	1212	29	prostate	prostate	NN
cord-000248-zueoyesj	1212	30	cancer	cancer	NN
cord-000248-zueoyesj	1213	1	A	a	DT
cord-000248-zueoyesj	1213	2	continuous	continuous	JJ
cord-000248-zueoyesj	1213	3	assay	assay	NN
cord-000248-zueoyesj	1213	4	for	for	IN
cord-000248-zueoyesj	1213	5	alpha	alpha	NN
cord-000248-zueoyesj	1213	6	-	-	HYPH
cord-000248-zueoyesj	1213	7	methylacylcoenzyme	methylacylcoenzyme	NNS
cord-000248-zueoyesj	1213	8	A	a	DT
cord-000248-zueoyesj	1213	9	racemase	racemase	NN
cord-000248-zueoyesj	1213	10	using	use	VBG
cord-000248-zueoyesj	1213	11	circular	circular	JJ
cord-000248-zueoyesj	1213	12	dichroism	dichroism	NNP
cord-000248-zueoyesj	1213	13	Group	Group	NNP
cord-000248-zueoyesj	1213	14	IIA	IIA	NNP
cord-000248-zueoyesj	1213	15	phospholipase	phospholipase	NN
cord-000248-zueoyesj	1213	16	A	A	NNP
cord-000248-zueoyesj	1213	17	as	as	IN
cord-000248-zueoyesj	1213	18	a	a	DT
cord-000248-zueoyesj	1213	19	prognostic	prognostic	JJ
cord-000248-zueoyesj	1213	20	marker	marker	NN
cord-000248-zueoyesj	1213	21	in	in	IN
cord-000248-zueoyesj	1213	22	prostate	prostate	NN
cord-000248-zueoyesj	1213	23	cancer	cancer	NN
cord-000248-zueoyesj	1213	24	:	:	:
cord-000248-zueoyesj	1213	25	relevance	relevance	NN
cord-000248-zueoyesj	1213	26	to	to	IN
cord-000248-zueoyesj	1213	27	clinicopathological	clinicopathological	JJ
cord-000248-zueoyesj	1213	28	variables	variable	NNS
cord-000248-zueoyesj	1213	29	and	and	CC
cord-000248-zueoyesj	1213	30	disease	disease	NN
cord-000248-zueoyesj	1213	31	-	-	HYPH
cord-000248-zueoyesj	1213	32	specific	specific	JJ
cord-000248-zueoyesj	1213	33	mortality	mortality	NN
cord-000248-zueoyesj	1213	34	Biomarkers	Biomarkers	NNPS
cord-000248-zueoyesj	1213	35	for	for	IN
cord-000248-zueoyesj	1213	36	prostate	prostate	NN
cord-000248-zueoyesj	1213	37	cancer	cancer	NN
cord-000248-zueoyesj	1214	1	Immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1214	2	algorithms	algorithm	NNS
cord-000248-zueoyesj	1214	3	in	in	IN
cord-000248-zueoyesj	1214	4	prostate	prostate	NN
cord-000248-zueoyesj	1214	5	diagnostics	diagnostic	NNS
cord-000248-zueoyesj	1215	1	:	:	:
cord-000248-zueoyesj	1215	2	What	what	WP
cord-000248-zueoyesj	1215	3	's	be	VBZ
cord-000248-zueoyesj	1215	4	new	new	JJ
cord-000248-zueoyesj	1215	5	?	?	.
cord-000248-zueoyesj	1215	6	]	]	-RRB-
cord-000248-zueoyesj	1215	7	.	.	.
cord-000248-zueoyesj	1216	1	Pathologe	Pathologe	NNP
cord-000248-zueoyesj	1216	2	Alpha	alpha	NN
cord-000248-zueoyesj	1216	3	-	-	HYPH
cord-000248-zueoyesj	1216	4	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1216	5	-	-	HYPH
cord-000248-zueoyesj	1216	6	CoA	coa	NN
cord-000248-zueoyesj	1216	7	racemase	racemase	NN
cord-000248-zueoyesj	1216	8	(	(	-LRB-
cord-000248-zueoyesj	1216	9	AMACR	AMACR	NNP
cord-000248-zueoyesj	1216	10	)	)	-RRB-
cord-000248-zueoyesj	1216	11	in	in	IN
cord-000248-zueoyesj	1216	12	fine	fine	JJ
cord-000248-zueoyesj	1216	13	-	-	HYPH
cord-000248-zueoyesj	1216	14	needle	needle	NN
cord-000248-zueoyesj	1216	15	aspiration	aspiration	NN
cord-000248-zueoyesj	1216	16	specimens	specimen	NNS
cord-000248-zueoyesj	1216	17	of	of	IN
cord-000248-zueoyesj	1216	18	prostate	prostate	NN
cord-000248-zueoyesj	1216	19	lesions	lesion	NNS
cord-000248-zueoyesj	1216	20	Biopsy	Biopsy	NNP
cord-000248-zueoyesj	1216	21	tissue	tissue	NN
cord-000248-zueoyesj	1216	22	microarray	microarray	NN
cord-000248-zueoyesj	1216	23	study	study	NN
cord-000248-zueoyesj	1216	24	of	of	IN
cord-000248-zueoyesj	1216	25	Ki-67	Ki-67	NNP
cord-000248-zueoyesj	1216	26	expression	expression	NN
cord-000248-zueoyesj	1216	27	in	in	IN
cord-000248-zueoyesj	1216	28	untreated	untreated	JJ
cord-000248-zueoyesj	1216	29	,	,	,
cord-000248-zueoyesj	1216	30	localized	localized	JJ
cord-000248-zueoyesj	1216	31	prostate	prostate	NN
cord-000248-zueoyesj	1216	32	cancer	cancer	NN
cord-000248-zueoyesj	1216	33	managed	manage	VBN
cord-000248-zueoyesj	1216	34	by	by	IN
cord-000248-zueoyesj	1216	35	active	active	JJ
cord-000248-zueoyesj	1216	36	surveillance	surveillance	NN
cord-000248-zueoyesj	1216	37	Urine	urine	NN
cord-000248-zueoyesj	1216	38	markers	marker	NNS
cord-000248-zueoyesj	1216	39	in	in	IN
cord-000248-zueoyesj	1216	40	monitoring	monitoring	NN
cord-000248-zueoyesj	1216	41	for	for	IN
cord-000248-zueoyesj	1216	42	prostate	prostate	NN
cord-000248-zueoyesj	1216	43	cancer	cancer	NN
cord-000248-zueoyesj	1216	44	Expression	expression	NN
cord-000248-zueoyesj	1216	45	of	of	IN
cord-000248-zueoyesj	1216	46	alpha	alpha	JJ
cord-000248-zueoyesj	1216	47	-	-	HYPH
cord-000248-zueoyesj	1216	48	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1216	49	-	-	HYPH
cord-000248-zueoyesj	1216	50	CoA	coa	NN
cord-000248-zueoyesj	1216	51	racemase	racemase	NN
cord-000248-zueoyesj	1216	52	(	(	-LRB-
cord-000248-zueoyesj	1216	53	P504S	P504S	NNP
cord-000248-zueoyesj	1216	54	)	)	-RRB-
cord-000248-zueoyesj	1216	55	in	in	IN
cord-000248-zueoyesj	1216	56	sebaceous	sebaceous	JJ
cord-000248-zueoyesj	1216	57	neoplasms	neoplasm	NNS
cord-000248-zueoyesj	1216	58	Expression	expression	NN
cord-000248-zueoyesj	1216	59	of	of	IN
cord-000248-zueoyesj	1216	60	prostatic	prostatic	JJ
cord-000248-zueoyesj	1216	61	acid	acid	NN
cord-000248-zueoyesj	1216	62	phosphatase	phosphatase	NN
cord-000248-zueoyesj	1216	63	(	(	-LRB-
cord-000248-zueoyesj	1216	64	PSAP	PSAP	NNP
cord-000248-zueoyesj	1216	65	)	)	-RRB-
cord-000248-zueoyesj	1216	66	in	in	IN
cord-000248-zueoyesj	1216	67	transurethral	transurethral	NN
cord-000248-zueoyesj	1216	68	resection	resection	NN
cord-000248-zueoyesj	1216	69	specimens	specimen	NNS
cord-000248-zueoyesj	1216	70	of	of	IN
cord-000248-zueoyesj	1216	71	the	the	DT
cord-000248-zueoyesj	1216	72	prostate	prostate	NN
cord-000248-zueoyesj	1216	73	is	be	VBZ
cord-000248-zueoyesj	1216	74	predictive	predictive	JJ
cord-000248-zueoyesj	1216	75	of	of	IN
cord-000248-zueoyesj	1216	76	histopathologic	histopathologic	JJ
cord-000248-zueoyesj	1216	77	tumor	tumor	NN
cord-000248-zueoyesj	1216	78	stage	stage	NN
cord-000248-zueoyesj	1216	79	in	in	IN
cord-000248-zueoyesj	1216	80	subsequent	subsequent	JJ
cord-000248-zueoyesj	1216	81	radical	radical	JJ
cord-000248-zueoyesj	1216	82	prostatectomies	prostatectomy	NNS
cord-000248-zueoyesj	1216	83	Prostate	prostate	NN
cord-000248-zueoyesj	1216	84	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1216	85	induced	induce	VBN
cord-000248-zueoyesj	1216	86	by	by	IN
cord-000248-zueoyesj	1216	87	N	n	CD
cord-000248-zueoyesj	1216	88	-	-	HYPH
cord-000248-zueoyesj	1216	89	methyl	methyl	NNP
cord-000248-zueoyesj	1216	90	-	-	HYPH
cord-000248-zueoyesj	1216	91	N	N	NNP
cord-000248-zueoyesj	1216	92	-	-	HYPH
cord-000248-zueoyesj	1216	93	nitrosourea	nitrosourea	NNP
cord-000248-zueoyesj	1216	94	(	(	-LRB-
cord-000248-zueoyesj	1216	95	mnu	mnu	NNP
cord-000248-zueoyesj	1216	96	)	)	-RRB-
cord-000248-zueoyesj	1216	97	in	in	IN
cord-000248-zueoyesj	1216	98	gerbils	gerbil	NNS
cord-000248-zueoyesj	1216	99	:	:	:
cord-000248-zueoyesj	1216	100	Histopathological	Histopathological	NNP
cord-000248-zueoyesj	1216	101	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1216	102	and	and	CC
cord-000248-zueoyesj	1216	103	potential	potential	JJ
cord-000248-zueoyesj	1216	104	invasiveness	invasiveness	NN
cord-000248-zueoyesj	1216	105	mediated	mediate	VBN
cord-000248-zueoyesj	1216	106	by	by	IN
cord-000248-zueoyesj	1216	107	extracellular	extracellular	JJ
cord-000248-zueoyesj	1216	108	matrix	matrix	NN
cord-000248-zueoyesj	1216	109	components	component	NNS
cord-000248-zueoyesj	1216	110	Synthesis	Synthesis	NNP
cord-000248-zueoyesj	1216	111	and	and	CC
cord-000248-zueoyesj	1216	112	use	use	NN
cord-000248-zueoyesj	1216	113	of	of	IN
cord-000248-zueoyesj	1216	114	isotope	isotope	NN
cord-000248-zueoyesj	1216	115	-	-	HYPH
cord-000248-zueoyesj	1216	116	labelled	label	VBN
cord-000248-zueoyesj	1216	117	substrates	substrate	NNS
cord-000248-zueoyesj	1216	118	for	for	IN
cord-000248-zueoyesj	1216	119	a	a	DT
cord-000248-zueoyesj	1216	120	mechanistic	mechanistic	JJ
cord-000248-zueoyesj	1216	121	study	study	NN
cord-000248-zueoyesj	1216	122	on	on	IN
cord-000248-zueoyesj	1216	123	human	human	JJ
cord-000248-zueoyesj	1216	124	alpha	alpha	JJ
cord-000248-zueoyesj	1216	125	-	-	HYPH
cord-000248-zueoyesj	1216	126	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1216	127	-	-	HYPH
cord-000248-zueoyesj	1216	128	CoA	coa	NN
cord-000248-zueoyesj	1216	129	racemase	racemase	NN
cord-000248-zueoyesj	1216	130	1A	1a	NN
cord-000248-zueoyesj	1216	131	(	(	-LRB-
cord-000248-zueoyesj	1216	132	AMACR	AMACR	NNP
cord-000248-zueoyesj	1216	133	;	;	:
cord-000248-zueoyesj	1216	134	P504S	P504S	NNP
cord-000248-zueoyesj	1216	135	)	)	-RRB-
cord-000248-zueoyesj	1217	1	S-100A1	S-100A1	NNP
cord-000248-zueoyesj	1217	2	Is	be	VBZ
cord-000248-zueoyesj	1217	3	a	a	DT
cord-000248-zueoyesj	1217	4	Reliable	reliable	JJ
cord-000248-zueoyesj	1217	5	Marker	marker	NN
cord-000248-zueoyesj	1217	6	in	in	IN
cord-000248-zueoyesj	1217	7	Distinguishing	distinguish	VBG
cord-000248-zueoyesj	1217	8	Nephrogenic	Nephrogenic	NNP
cord-000248-zueoyesj	1217	9	Adenoma	Adenoma	NNP
cord-000248-zueoyesj	1217	10	From	from	IN
cord-000248-zueoyesj	1217	11	Prostatic	Prostatic	NNP
cord-000248-zueoyesj	1217	12	Adenocarcinoma	Adenocarcinoma	NNP
cord-000248-zueoyesj	1217	13	Molecular	Molecular	NNP
cord-000248-zueoyesj	1217	14	cloning	clone	VBG
cord-000248-zueoyesj	1217	15	and	and	CC
cord-000248-zueoyesj	1217	16	preliminary	preliminary	JJ
cord-000248-zueoyesj	1217	17	analysis	analysis	NN
cord-000248-zueoyesj	1217	18	of	of	IN
cord-000248-zueoyesj	1217	19	the	the	DT
cord-000248-zueoyesj	1217	20	human	human	JJ
cord-000248-zueoyesj	1217	21	alpha	alpha	JJ
cord-000248-zueoyesj	1217	22	-	-	HYPH
cord-000248-zueoyesj	1217	23	methylacyl	methylacyl	JJ
cord-000248-zueoyesj	1217	24	-	-	HYPH
cord-000248-zueoyesj	1217	25	CoA	coa	NN
cord-000248-zueoyesj	1217	26	racemase	racemase	NN
cord-000248-zueoyesj	1217	27	promoter	promoter	NN
cord-000248-zueoyesj	1217	28	Autopsy	Autopsy	NNP
cord-000248-zueoyesj	1217	29	evaluation	evaluation	NN
cord-000248-zueoyesj	1217	30	of	of	IN
cord-000248-zueoyesj	1217	31	a	a	DT
cord-000248-zueoyesj	1217	32	prostate	prostate	NN
cord-000248-zueoyesj	1217	33	cancer	cancer	NN
cord-000248-zueoyesj	1217	34	case	case	NN
cord-000248-zueoyesj	1217	35	treated	treat	VBN
cord-000248-zueoyesj	1217	36	with	with	IN
cord-000248-zueoyesj	1217	37	brachytherapy	brachytherapy	NN
cord-000248-zueoyesj	1217	38	Loss	loss	NN
cord-000248-zueoyesj	1217	39	of	of	IN
cord-000248-zueoyesj	1217	40	heterozygosity	heterozygosity	NN
cord-000248-zueoyesj	1217	41	(	(	-LRB-
cord-000248-zueoyesj	1217	42	LOH	LOH	NNP
cord-000248-zueoyesj	1217	43	)	)	-RRB-
cord-000248-zueoyesj	1217	44	,	,	,
cord-000248-zueoyesj	1217	45	malignancy	malignancy	NN
cord-000248-zueoyesj	1217	46	grade	grade	NN
cord-000248-zueoyesj	1217	47	and	and	CC
cord-000248-zueoyesj	1217	48	clonality	clonality	NN
cord-000248-zueoyesj	1217	49	in	in	IN
cord-000248-zueoyesj	1217	50	microdissected	microdissected	JJ
cord-000248-zueoyesj	1217	51	prostate	prostate	NN
cord-000248-zueoyesj	1217	52	cancer	cancer	NN
cord-000248-zueoyesj	1217	53	Allelic	Allelic	NNP
cord-000248-zueoyesj	1217	54	loss	loss	NN
cord-000248-zueoyesj	1217	55	and	and	CC
cord-000248-zueoyesj	1217	56	microsatellite	microsatellite	JJ
cord-000248-zueoyesj	1217	57	instability	instability	NN
cord-000248-zueoyesj	1217	58	in	in	IN
cord-000248-zueoyesj	1217	59	prostate	prostate	NN
cord-000248-zueoyesj	1217	60	cancers	cancer	NNS
cord-000248-zueoyesj	1217	61	in	in	IN
cord-000248-zueoyesj	1217	62	Japan	Japan	NNP
cord-000248-zueoyesj	1217	63	tumour	tumour	NN
cord-000248-zueoyesj	1217	64	suppressor	suppressor	NN
cord-000248-zueoyesj	1217	65	gene	gene	NN
cord-000248-zueoyesj	1217	66	mutations	mutation	NNS
cord-000248-zueoyesj	1217	67	in	in	IN
cord-000248-zueoyesj	1217	68	benign	benign	JJ
cord-000248-zueoyesj	1217	69	prostatic	prostatic	JJ
cord-000248-zueoyesj	1217	70	hyperplasia	hyperplasia	NN
cord-000248-zueoyesj	1217	71	and	and	CC
cord-000248-zueoyesj	1217	72	prostate	prostate	NN
cord-000248-zueoyesj	1217	73	cancer	cancer	NN
cord-000248-zueoyesj	1217	74	Mutations	Mutations	NNPS
cord-000248-zueoyesj	1217	75	in	in	IN
cord-000248-zueoyesj	1217	76	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1217	77	and	and	CC
cord-000248-zueoyesj	1217	78	BRCA2	brca2	NN
cord-000248-zueoyesj	1217	79	and	and	CC
cord-000248-zueoyesj	1217	80	predisposition	predisposition	NN
cord-000248-zueoyesj	1217	81	to	to	IN
cord-000248-zueoyesj	1217	82	prostate	prostate	NN
cord-000248-zueoyesj	1217	83	cancer	cancer	NN
cord-000248-zueoyesj	1217	84	BRCA1a	brca1a	NN
cord-000248-zueoyesj	1217	85	has	have	VBZ
cord-000248-zueoyesj	1217	86	antitumor	antitumor	JJ
cord-000248-zueoyesj	1217	87	activity	activity	NN
cord-000248-zueoyesj	1217	88	in	in	IN
cord-000248-zueoyesj	1217	89	TN	TN	NNP
cord-000248-zueoyesj	1217	90	breast	breast	NN
cord-000248-zueoyesj	1217	91	,	,	,
cord-000248-zueoyesj	1217	92	ovarian	ovarian	NN
cord-000248-zueoyesj	1217	93	and	and	CC
cord-000248-zueoyesj	1217	94	prostate	prostate	NN
cord-000248-zueoyesj	1217	95	cancers	cancer	NNS
cord-000248-zueoyesj	1218	1	Coexpression	coexpression	NN
cord-000248-zueoyesj	1218	2	of	of	IN
cord-000248-zueoyesj	1218	3	the	the	DT
cord-000248-zueoyesj	1218	4	mutated	mutate	VBN
cord-000248-zueoyesj	1218	5	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1218	6	mRNA	mRNA	NNP
cord-000248-zueoyesj	1218	7	and	and	CC
cord-000248-zueoyesj	1218	8	p53	p53	NN
cord-000248-zueoyesj	1218	9	mRNA	mRNA	NNP
cord-000248-zueoyesj	1218	10	and	and	CC
cord-000248-zueoyesj	1218	11	its	-PRON-	PRP$
cord-000248-zueoyesj	1218	12	association	association	NN
cord-000248-zueoyesj	1218	13	in	in	IN
cord-000248-zueoyesj	1218	14	Chinese	chinese	JJ
cord-000248-zueoyesj	1218	15	prostate	prostate	NN
cord-000248-zueoyesj	1218	16	cancer	cancer	NN
cord-000248-zueoyesj	1218	17	Exploiting	exploit	VBG
cord-000248-zueoyesj	1218	18	the	the	DT
cord-000248-zueoyesj	1218	19	Achilles	Achilles	NNP
cord-000248-zueoyesj	1218	20	heel	heel	NN
cord-000248-zueoyesj	1218	21	of	of	IN
cord-000248-zueoyesj	1218	22	cancer	cancer	NN
cord-000248-zueoyesj	1218	23	:	:	:
cord-000248-zueoyesj	1218	24	the	the	DT
cord-000248-zueoyesj	1218	25	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1218	26	potential	potential	NN
cord-000248-zueoyesj	1218	27	of	of	IN
cord-000248-zueoyesj	1218	28	poly(ADP	poly(adp	NN
cord-000248-zueoyesj	1218	29	-	-	HYPH
cord-000248-zueoyesj	1218	30	ribose	ribose	NN
cord-000248-zueoyesj	1218	31	)	)	-RRB-
cord-000248-zueoyesj	1218	32	polymerase	polymerase	NN
cord-000248-zueoyesj	1218	33	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	1218	34	in	in	IN
cord-000248-zueoyesj	1218	35	BRCA2-defective	BRCA2-defective	NNP
cord-000248-zueoyesj	1218	36	cancer	cancer	NN
cord-000248-zueoyesj	1218	37	Prostate	prostate	NN
cord-000248-zueoyesj	1218	38	cancer	cancer	NN
cord-000248-zueoyesj	1218	39	patients	patient	NNS
cord-000248-zueoyesj	1218	40	with	with	IN
cord-000248-zueoyesj	1218	41	BRCA2	brca2	NN
cord-000248-zueoyesj	1218	42	mutation	mutation	NN
cord-000248-zueoyesj	1218	43	face	face	VBP
cord-000248-zueoyesj	1218	44	poor	poor	JJ
cord-000248-zueoyesj	1218	45	survival	survival	NN
cord-000248-zueoyesj	1219	1	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1219	2	mutations	mutation	NNS
cord-000248-zueoyesj	1219	3	and	and	CC
cord-000248-zueoyesj	1219	4	prostate	prostate	NN
cord-000248-zueoyesj	1219	5	cancer	cancer	NN
cord-000248-zueoyesj	1219	6	in	in	IN
cord-000248-zueoyesj	1219	7	Poland	Poland	NNP
cord-000248-zueoyesj	1219	8	Common	common	JJ
cord-000248-zueoyesj	1219	9	variation	variation	NN
cord-000248-zueoyesj	1219	10	in	in	IN
cord-000248-zueoyesj	1219	11	the	the	DT
cord-000248-zueoyesj	1219	12	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1219	13	gene	gene	NN
cord-000248-zueoyesj	1219	14	and	and	CC
cord-000248-zueoyesj	1219	15	prostate	prostate	NN
cord-000248-zueoyesj	1219	16	cancer	cancer	NN
cord-000248-zueoyesj	1219	17	risk	risk	NN
cord-000248-zueoyesj	1219	18	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1219	19	in	in	IN
cord-000248-zueoyesj	1219	20	special	special	JJ
cord-000248-zueoyesj	1219	21	populations	population	NNS
cord-000248-zueoyesj	1220	1	Male	male	JJ
cord-000248-zueoyesj	1220	2	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1220	3	and	and	CC
cord-000248-zueoyesj	1220	4	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	1220	5	mutation	mutation	NN
cord-000248-zueoyesj	1220	6	carriers	carrier	NNS
cord-000248-zueoyesj	1220	7	:	:	:
cord-000248-zueoyesj	1220	8	a	a	DT
cord-000248-zueoyesj	1220	9	pilot	pilot	NN
cord-000248-zueoyesj	1220	10	study	study	NN
cord-000248-zueoyesj	1220	11	investigating	investigate	VBG
cord-000248-zueoyesj	1220	12	medical	medical	JJ
cord-000248-zueoyesj	1220	13	characteristics	characteristic	NNS
cord-000248-zueoyesj	1220	14	of	of	IN
cord-000248-zueoyesj	1220	15	patients	patient	NNS
cord-000248-zueoyesj	1220	16	participating	participate	VBG
cord-000248-zueoyesj	1220	17	in	in	IN
cord-000248-zueoyesj	1220	18	a	a	DT
cord-000248-zueoyesj	1220	19	prostate	prostate	NN
cord-000248-zueoyesj	1220	20	cancer	cancer	NN
cord-000248-zueoyesj	1220	21	prevention	prevention	NN
cord-000248-zueoyesj	1220	22	clinic	clinic	NN
cord-000248-zueoyesj	1221	1	Truncating	truncate	VBG
cord-000248-zueoyesj	1222	1	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1222	2	mutations	mutation	NNS
cord-000248-zueoyesj	1222	3	are	be	VBP
cord-000248-zueoyesj	1222	4	uncommon	uncommon	JJ
cord-000248-zueoyesj	1222	5	in	in	IN
cord-000248-zueoyesj	1222	6	a	a	DT
cord-000248-zueoyesj	1222	7	cohort	cohort	NN
cord-000248-zueoyesj	1222	8	of	of	IN
cord-000248-zueoyesj	1222	9	hereditary	hereditary	JJ
cord-000248-zueoyesj	1222	10	prostate	prostate	NN
cord-000248-zueoyesj	1222	11	cancer	cancer	NN
cord-000248-zueoyesj	1222	12	families	family	NNS
cord-000248-zueoyesj	1222	13	with	with	IN
cord-000248-zueoyesj	1222	14	evidence	evidence	NN
cord-000248-zueoyesj	1222	15	of	of	IN
cord-000248-zueoyesj	1222	16	linkage	linkage	NN
cord-000248-zueoyesj	1222	17	to	to	IN
cord-000248-zueoyesj	1222	18	17q	17q	CD
cord-000248-zueoyesj	1222	19	markers	marker	NNS
cord-000248-zueoyesj	1222	20	Unravelling	unravel	VBG
cord-000248-zueoyesj	1222	21	the	the	DT
cord-000248-zueoyesj	1222	22	genetics	genetic	NNS
cord-000248-zueoyesj	1222	23	of	of	IN
cord-000248-zueoyesj	1222	24	prostate	prostate	NN
cord-000248-zueoyesj	1222	25	cancer	cancer	NN
cord-000248-zueoyesj	1222	26	Prostate	prostate	NN
cord-000248-zueoyesj	1222	27	-	-	HYPH
cord-000248-zueoyesj	1222	28	cancer	cancer	NN
cord-000248-zueoyesj	1222	29	screening	screening	NN
cord-000248-zueoyesj	1222	30	targets	target	NNS
cord-000248-zueoyesj	1222	31	men	man	NNS
cord-000248-zueoyesj	1222	32	with	with	IN
cord-000248-zueoyesj	1222	33	BRCA	BRCA	NNP
cord-000248-zueoyesj	1222	34	mutations	mutation	NNS
cord-000248-zueoyesj	1222	35	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1222	36	and	and	CC
cord-000248-zueoyesj	1222	37	prostate	prostate	NN
cord-000248-zueoyesj	1222	38	cancer	cancer	NN
cord-000248-zueoyesj	1222	39	gene	gene	NN
cord-000248-zueoyesj	1222	40	mutational	mutational	JJ
cord-000248-zueoyesj	1222	41	rate	rate	NN
cord-000248-zueoyesj	1222	42	,	,	,
cord-000248-zueoyesj	1222	43	Gleason	Gleason	NNP
cord-000248-zueoyesj	1222	44	score	score	NN
cord-000248-zueoyesj	1222	45	,	,	,
cord-000248-zueoyesj	1222	46	and	and	CC
cord-000248-zueoyesj	1222	47	BK	BK	NNP
cord-000248-zueoyesj	1222	48	virus	virus	NN
cord-000248-zueoyesj	1222	49	infection	infection	NN
cord-000248-zueoyesj	1222	50	in	in	IN
cord-000248-zueoyesj	1222	51	prostate	prostate	NN
cord-000248-zueoyesj	1222	52	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1222	53	:	:	:
cord-000248-zueoyesj	1222	54	Is	be	VBZ
cord-000248-zueoyesj	1222	55	there	there	EX
cord-000248-zueoyesj	1222	56	a	a	DT
cord-000248-zueoyesj	1222	57	correlation	correlation	NN
cord-000248-zueoyesj	1222	58	TP53	TP53	NNP
cord-000248-zueoyesj	1222	59	mutation	mutation	NN
cord-000248-zueoyesj	1222	60	in	in	IN
cord-000248-zueoyesj	1222	61	prostate	prostate	NN
cord-000248-zueoyesj	1222	62	needle	needle	NN
cord-000248-zueoyesj	1222	63	biopsies	biopsy	NNS
cord-000248-zueoyesj	1222	64	-	-	:
cord-000248-zueoyesj	1222	65	comparison	comparison	NN
cord-000248-zueoyesj	1222	66	with	with	IN
cord-000248-zueoyesj	1222	67	patients	patient	NNS
cord-000248-zueoyesj	1222	68	follow	follow	VB
cord-000248-zueoyesj	1222	69	-	-	HYPH
cord-000248-zueoyesj	1222	70	up	up	NN
cord-000248-zueoyesj	1222	71	Shared	Shared	NNP
cord-000248-zueoyesj	1222	72	TP53	TP53	NNP
cord-000248-zueoyesj	1222	73	gene	gene	NN
cord-000248-zueoyesj	1222	74	mutation	mutation	NN
cord-000248-zueoyesj	1222	75	in	in	IN
cord-000248-zueoyesj	1222	76	morphologically	morphologically	RB
cord-000248-zueoyesj	1222	77	and	and	CC
cord-000248-zueoyesj	1222	78	phenotypically	phenotypically	RB
cord-000248-zueoyesj	1222	79	distinct	distinct	JJ
cord-000248-zueoyesj	1222	80	concurrent	concurrent	JJ
cord-000248-zueoyesj	1222	81	primary	primary	JJ
cord-000248-zueoyesj	1222	82	small	small	JJ
cord-000248-zueoyesj	1222	83	cell	cell	NN
cord-000248-zueoyesj	1222	84	neuroendocrine	neuroendocrine	JJ
cord-000248-zueoyesj	1222	85	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1222	86	and	and	CC
cord-000248-zueoyesj	1222	87	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1222	88	of	of	IN
cord-000248-zueoyesj	1222	89	the	the	DT
cord-000248-zueoyesj	1222	90	prostate	prostate	NN
cord-000248-zueoyesj	1222	91	Unique	unique	JJ
cord-000248-zueoyesj	1222	92	substitution	substitution	NN
cord-000248-zueoyesj	1222	93	of	of	IN
cord-000248-zueoyesj	1222	94	CHEK2	CHEK2	NNP
cord-000248-zueoyesj	1222	95	and	and	CC
cord-000248-zueoyesj	1223	1	TP53	TP53	NNP
cord-000248-zueoyesj	1223	2	mutations	mutation	NNS
cord-000248-zueoyesj	1223	3	implicated	implicate	VBN
cord-000248-zueoyesj	1223	4	in	in	IN
cord-000248-zueoyesj	1223	5	primary	primary	JJ
cord-000248-zueoyesj	1223	6	prostate	prostate	NN
cord-000248-zueoyesj	1223	7	tumors	tumor	NNS
cord-000248-zueoyesj	1223	8	and	and	CC
cord-000248-zueoyesj	1223	9	cancer	cancer	NN
cord-000248-zueoyesj	1223	10	cell	cell	NN
cord-000248-zueoyesj	1223	11	lines	line	NNS
cord-000248-zueoyesj	1223	12	Molecular	molecular	JJ
cord-000248-zueoyesj	1223	13	biology	biology	NN
cord-000248-zueoyesj	1223	14	in	in	IN
cord-000248-zueoyesj	1223	15	prostate	prostate	NN
cord-000248-zueoyesj	1223	16	cancer	cancer	NN
cord-000248-zueoyesj	1224	1	A	a	DT
cord-000248-zueoyesj	1224	2	microdissection	microdissection	NN
cord-000248-zueoyesj	1224	3	approach	approach	NN
cord-000248-zueoyesj	1224	4	to	to	TO
cord-000248-zueoyesj	1224	5	detect	detect	VB
cord-000248-zueoyesj	1224	6	molecular	molecular	JJ
cord-000248-zueoyesj	1224	7	markers	marker	NNS
cord-000248-zueoyesj	1224	8	during	during	IN
cord-000248-zueoyesj	1224	9	progression	progression	NN
cord-000248-zueoyesj	1224	10	of	of	IN
cord-000248-zueoyesj	1224	11	prostate	prostate	NN
cord-000248-zueoyesj	1224	12	cancer	cancer	NN
cord-000248-zueoyesj	1224	13	Molecular	molecular	JJ
cord-000248-zueoyesj	1224	14	biology	biology	NN
cord-000248-zueoyesj	1224	15	of	of	IN
cord-000248-zueoyesj	1224	16	prostate	prostate	NN
cord-000248-zueoyesj	1225	1	cancer	cancer	NN
cord-000248-zueoyesj	1225	2	progression	progression	NN
cord-000248-zueoyesj	1226	1	Molecular	molecular	JJ
cord-000248-zueoyesj	1226	2	heterogeneity	heterogeneity	NN
cord-000248-zueoyesj	1226	3	in	in	IN
cord-000248-zueoyesj	1226	4	prostate	prostate	NN
cord-000248-zueoyesj	1226	5	cancer	cancer	NN
cord-000248-zueoyesj	1226	6	:	:	:
cord-000248-zueoyesj	1226	7	can	can	MD
cord-000248-zueoyesj	1226	8	TP53	TP53	NNP
cord-000248-zueoyesj	1226	9	mutation	mutation	NN
cord-000248-zueoyesj	1226	10	unravel	unravel	VBP
cord-000248-zueoyesj	1226	11	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1226	12	abnormalities	abnormality	NNS
cord-000248-zueoyesj	1226	13	in	in	IN
cord-000248-zueoyesj	1226	14	primary	primary	JJ
cord-000248-zueoyesj	1226	15	prostate	prostate	NN
cord-000248-zueoyesj	1226	16	cancer	cancer	NN
cord-000248-zueoyesj	1226	17	:	:	:
cord-000248-zueoyesj	1226	18	single	single	JJ
cord-000248-zueoyesj	1226	19	-	-	HYPH
cord-000248-zueoyesj	1226	20	strand	strand	NN
cord-000248-zueoyesj	1226	21	conformation	conformation	NN
cord-000248-zueoyesj	1226	22	polymorphism	polymorphism	NN
cord-000248-zueoyesj	1226	23	analysis	analysis	NN
cord-000248-zueoyesj	1226	24	of	of	IN
cord-000248-zueoyesj	1226	25	complementary	complementary	JJ
cord-000248-zueoyesj	1226	26	DNA	dna	NN
cord-000248-zueoyesj	1226	27	in	in	IN
cord-000248-zueoyesj	1226	28	comparison	comparison	NN
cord-000248-zueoyesj	1226	29	with	with	IN
cord-000248-zueoyesj	1226	30	genomic	genomic	JJ
cord-000248-zueoyesj	1226	31	DNA	dna	NN
cord-000248-zueoyesj	1226	32	.	.	.
cord-000248-zueoyesj	1227	1	The	the	DT
cord-000248-zueoyesj	1227	2	Cooperative	Cooperative	NNP
cord-000248-zueoyesj	1227	3	Prostate	Prostate	NNP
cord-000248-zueoyesj	1227	4	Network	Network	NNP
cord-000248-zueoyesj	1227	5	status	status	NN
cord-000248-zueoyesj	1227	6	and	and	CC
cord-000248-zueoyesj	1227	7	prognosis	prognosis	NN
cord-000248-zueoyesj	1227	8	of	of	IN
cord-000248-zueoyesj	1227	9	locally	locally	RB
cord-000248-zueoyesj	1227	10	advanced	advanced	JJ
cord-000248-zueoyesj	1227	11	prostatic	prostatic	JJ
cord-000248-zueoyesj	1227	12	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1227	13	:	:	:
cord-000248-zueoyesj	1227	14	a	a	DT
cord-000248-zueoyesj	1227	15	study	study	NN
cord-000248-zueoyesj	1227	16	based	base	VBN
cord-000248-zueoyesj	1227	17	on	on	IN
cord-000248-zueoyesj	1227	18	RTOG	RTOG	NNP
cord-000248-zueoyesj	1227	19	8610	8610	CD
cord-000248-zueoyesj	1227	20	Localization	Localization	NNP
cord-000248-zueoyesj	1227	21	of	of	IN
cord-000248-zueoyesj	1227	22	prostate	prostate	NN
cord-000248-zueoyesj	1227	23	cancer	cancer	NN
cord-000248-zueoyesj	1227	24	metastasis	metastasis	NN
cord-000248-zueoyesj	1227	25	-	-	HYPH
cord-000248-zueoyesj	1227	26	suppressor	suppressor	NN
cord-000248-zueoyesj	1227	27	activity	activity	NN
cord-000248-zueoyesj	1227	28	on	on	IN
cord-000248-zueoyesj	1227	29	human	human	JJ
cord-000248-zueoyesj	1227	30	chromosome	chromosome	NN
cord-000248-zueoyesj	1227	31	17	17	CD
cord-000248-zueoyesj	1227	32	Correlation	correlation	NN
cord-000248-zueoyesj	1227	33	of	of	IN
cord-000248-zueoyesj	1227	34	genetic	genetic	JJ
cord-000248-zueoyesj	1227	35	and	and	CC
cord-000248-zueoyesj	1227	36	immunodetection	immunodetection	NN
cord-000248-zueoyesj	1227	37	of	of	IN
cord-000248-zueoyesj	1227	38	TP53	TP53	NNP
cord-000248-zueoyesj	1227	39	mutations	mutation	NNS
cord-000248-zueoyesj	1227	40	in	in	IN
cord-000248-zueoyesj	1227	41	malignant	malignant	JJ
cord-000248-zueoyesj	1227	42	and	and	CC
cord-000248-zueoyesj	1227	43	benign	benign	JJ
cord-000248-zueoyesj	1227	44	prostate	prostate	NN
cord-000248-zueoyesj	1227	45	tissues	tissue	NNS
cord-000248-zueoyesj	1227	46	Molecular	molecular	JJ
cord-000248-zueoyesj	1227	47	markers	marker	NNS
cord-000248-zueoyesj	1227	48	for	for	IN
cord-000248-zueoyesj	1227	49	predicting	predict	VBG
cord-000248-zueoyesj	1227	50	prostate	prostate	NN
cord-000248-zueoyesj	1227	51	cancer	cancer	NN
cord-000248-zueoyesj	1227	52	stage	stage	NN
cord-000248-zueoyesj	1227	53	and	and	CC
cord-000248-zueoyesj	1227	54	survival	survival	NN
cord-000248-zueoyesj	1227	55	Role	role	NN
cord-000248-zueoyesj	1227	56	in	in	IN
cord-000248-zueoyesj	1227	57	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1227	58	of	of	IN
cord-000248-zueoyesj	1227	59	silent	silent	JJ
cord-000248-zueoyesj	1227	60	mutations	mutation	NNS
cord-000248-zueoyesj	1227	61	in	in	IN
cord-000248-zueoyesj	1227	62	the	the	DT
cord-000248-zueoyesj	1227	63	TP53	TP53	NNP
cord-000248-zueoyesj	1227	64	gene	gene	NN
cord-000248-zueoyesj	1227	65	Chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1227	66	imbalances	imbalance	NNS
cord-000248-zueoyesj	1227	67	,	,	,
cord-000248-zueoyesj	1227	68	loss	loss	NN
cord-000248-zueoyesj	1227	69	of	of	IN
cord-000248-zueoyesj	1227	70	heterozygosity	heterozygosity	NN
cord-000248-zueoyesj	1227	71	,	,	,
cord-000248-zueoyesj	1227	72	and	and	CC
cord-000248-zueoyesj	1227	73	immunohistochemical	immunohistochemical	JJ
cord-000248-zueoyesj	1227	74	expression	expression	NN
cord-000248-zueoyesj	1227	75	of	of	IN
cord-000248-zueoyesj	1227	76	TP53	TP53	NNP
cord-000248-zueoyesj	1227	77	,	,	,
cord-000248-zueoyesj	1227	78	RB1	RB1	NNP
cord-000248-zueoyesj	1227	79	,	,	,
cord-000248-zueoyesj	1227	80	and	and	CC
cord-000248-zueoyesj	1227	81	PTEN	PTEN	NNP
cord-000248-zueoyesj	1227	82	in	in	IN
cord-000248-zueoyesj	1227	83	intraductal	intraductal	JJ
cord-000248-zueoyesj	1227	84	cancer	cancer	NN
cord-000248-zueoyesj	1227	85	,	,	,
cord-000248-zueoyesj	1227	86	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	1227	87	neoplasia	neoplasia	NN
cord-000248-zueoyesj	1227	88	,	,	,
cord-000248-zueoyesj	1227	89	and	and	CC
cord-000248-zueoyesj	1227	90	invasive	invasive	JJ
cord-000248-zueoyesj	1227	91	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1227	92	of	of	IN
cord-000248-zueoyesj	1227	93	the	the	DT
cord-000248-zueoyesj	1227	94	prostate	prostate	NN
cord-000248-zueoyesj	1227	95	Increase	increase	NN
cord-000248-zueoyesj	1227	96	of	of	IN
cord-000248-zueoyesj	1227	97	androgen	androgen	NN
cord-000248-zueoyesj	1227	98	-	-	HYPH
cord-000248-zueoyesj	1227	99	induced	induce	VBN
cord-000248-zueoyesj	1227	100	cell	cell	NN
cord-000248-zueoyesj	1227	101	death	death	NN
cord-000248-zueoyesj	1227	102	and	and	CC
cord-000248-zueoyesj	1227	103	androgen	androgen	NN
cord-000248-zueoyesj	1227	104	receptor	receptor	NN
cord-000248-zueoyesj	1227	105	transactivation	transactivation	NN
cord-000248-zueoyesj	1227	106	by	by	IN
cord-000248-zueoyesj	1227	107	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1227	108	in	in	IN
cord-000248-zueoyesj	1227	109	prostate	prostate	NN
cord-000248-zueoyesj	1227	110	cancer	cancer	NN
cord-000248-zueoyesj	1227	111	cells	cell	NNS
cord-000248-zueoyesj	1228	1	Androgen	androgen	NN
cord-000248-zueoyesj	1228	2	regulation	regulation	NN
cord-000248-zueoyesj	1228	3	of	of	IN
cord-000248-zueoyesj	1228	4	the	the	DT
cord-000248-zueoyesj	1228	5	androgen	androgen	NN
cord-000248-zueoyesj	1228	6	receptor	receptor	NN
cord-000248-zueoyesj	1228	7	coregulators	coregulator	VBZ
cord-000248-zueoyesj	1228	8	Breast	breast	NN
cord-000248-zueoyesj	1228	9	cancer	cancer	NN
cord-000248-zueoyesj	1228	10	susceptibility	susceptibility	NN
cord-000248-zueoyesj	1228	11	gene	gene	NN
cord-000248-zueoyesj	1228	12	1	1	CD
cord-000248-zueoyesj	1228	13	(	(	-LRB-
cord-000248-zueoyesj	1228	14	BRCAI	BRCAI	NNP
cord-000248-zueoyesj	1228	15	)	)	-RRB-
cord-000248-zueoyesj	1228	16	is	be	VBZ
cord-000248-zueoyesj	1228	17	a	a	DT
cord-000248-zueoyesj	1228	18	coactivator	coactivator	NN
cord-000248-zueoyesj	1228	19	of	of	IN
cord-000248-zueoyesj	1228	20	the	the	DT
cord-000248-zueoyesj	1228	21	androgen	androgen	NN
cord-000248-zueoyesj	1228	22	receptor	receptor	NN
cord-000248-zueoyesj	1228	23	Common	common	JJ
cord-000248-zueoyesj	1228	24	mutations	mutation	NNS
cord-000248-zueoyesj	1228	25	in	in	IN
cord-000248-zueoyesj	1228	26	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1228	27	and	and	CC
cord-000248-zueoyesj	1228	28	BRCA2	BRCA2	NNP
cord-000248-zueoyesj	1228	29	do	do	VBP
cord-000248-zueoyesj	1228	30	not	not	RB
cord-000248-zueoyesj	1228	31	contribute	contribute	VB
cord-000248-zueoyesj	1228	32	to	to	IN
cord-000248-zueoyesj	1228	33	early	early	JJ
cord-000248-zueoyesj	1228	34	prostate	prostate	NN
cord-000248-zueoyesj	1228	35	cancer	cancer	NN
cord-000248-zueoyesj	1228	36	in	in	IN
cord-000248-zueoyesj	1228	37	Jewish	jewish	JJ
cord-000248-zueoyesj	1228	38	men	man	NNS
cord-000248-zueoyesj	1228	39	BRCA1	brca1	VBP
cord-000248-zueoyesj	1228	40	in	in	IN
cord-000248-zueoyesj	1228	41	hormonal	hormonal	JJ
cord-000248-zueoyesj	1228	42	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1228	43	:	:	:
cord-000248-zueoyesj	1229	1	basic	basic	JJ
cord-000248-zueoyesj	1229	2	and	and	CC
cord-000248-zueoyesj	1229	3	clinical	clinical	JJ
cord-000248-zueoyesj	1229	4	research	research	NN
cord-000248-zueoyesj	1229	5	Role	role	NN
cord-000248-zueoyesj	1229	6	of	of	IN
cord-000248-zueoyesj	1229	7	direct	direct	JJ
cord-000248-zueoyesj	1229	8	interaction	interaction	NN
cord-000248-zueoyesj	1229	9	in	in	IN
cord-000248-zueoyesj	1229	10	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1229	11	inhibition	inhibition	NN
cord-000248-zueoyesj	1229	12	of	of	IN
cord-000248-zueoyesj	1229	13	estrogen	estrogen	NN
cord-000248-zueoyesj	1229	14	receptor	receptor	NN
cord-000248-zueoyesj	1229	15	activity	activity	NN
cord-000248-zueoyesj	1230	1	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1230	2	regulates	regulate	VBZ
cord-000248-zueoyesj	1230	3	gene	gene	NN
cord-000248-zueoyesj	1230	4	expression	expression	NN
cord-000248-zueoyesj	1230	5	for	for	IN
cord-000248-zueoyesj	1230	6	orderly	orderly	JJ
cord-000248-zueoyesj	1230	7	mitotic	mitotic	JJ
cord-000248-zueoyesj	1230	8	progression	progression	NN
cord-000248-zueoyesj	1231	1	The	the	DT
cord-000248-zueoyesj	1231	2	consequences	consequence	NNS
cord-000248-zueoyesj	1231	3	of	of	IN
cord-000248-zueoyesj	1231	4	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1231	5	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1231	6	on	on	IN
cord-000248-zueoyesj	1231	7	gene	gene	NN
cord-000248-zueoyesj	1231	8	expression	expression	NN
cord-000248-zueoyesj	1231	9	profiles	profile	NNS
cord-000248-zueoyesj	1231	10	in	in	IN
cord-000248-zueoyesj	1231	11	a	a	DT
cord-000248-zueoyesj	1231	12	cell	cell	NN
cord-000248-zueoyesj	1231	13	line	line	NN
cord-000248-zueoyesj	1231	14	model	model	NN
cord-000248-zueoyesj	1231	15	for	for	IN
cord-000248-zueoyesj	1231	16	prostate	prostate	NN
cord-000248-zueoyesj	1231	17	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1231	18	Constitutive	constitutive	JJ
cord-000248-zueoyesj	1231	19	activation	activation	NN
cord-000248-zueoyesj	1231	20	of	of	IN
cord-000248-zueoyesj	1231	21	JAK	JAK	NNP
cord-000248-zueoyesj	1231	22	-	-	HYPH
cord-000248-zueoyesj	1231	23	STAT3	STAT3	NNP
cord-000248-zueoyesj	1231	24	signaling	signal	VBG
cord-000248-zueoyesj	1231	25	by	by	IN
cord-000248-zueoyesj	1231	26	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1231	27	in	in	IN
cord-000248-zueoyesj	1231	28	human	human	JJ
cord-000248-zueoyesj	1231	29	prostate	prostate	NN
cord-000248-zueoyesj	1231	30	cancer	cancer	NN
cord-000248-zueoyesj	1231	31	cells	cell	NNS
cord-000248-zueoyesj	1231	32	Methylation	Methylation	NNP
cord-000248-zueoyesj	1231	33	analysis	analysis	NN
cord-000248-zueoyesj	1231	34	of	of	IN
cord-000248-zueoyesj	1231	35	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1231	36	,	,	,
cord-000248-zueoyesj	1231	37	RASSF1	RASSF1	NNS
cord-000248-zueoyesj	1231	38	,	,	,
cord-000248-zueoyesj	1231	39	GSTP1	gstp1	NN
cord-000248-zueoyesj	1231	40	and	and	CC
cord-000248-zueoyesj	1231	41	EPHB2	EPHB2	VBZ
cord-000248-zueoyesj	1231	42	promoters	promoter	NNS
cord-000248-zueoyesj	1231	43	in	in	IN
cord-000248-zueoyesj	1231	44	prostate	prostate	NN
cord-000248-zueoyesj	1231	45	biopsies	biopsy	NNS
cord-000248-zueoyesj	1231	46	according	accord	VBG
cord-000248-zueoyesj	1231	47	to	to	IN
cord-000248-zueoyesj	1231	48	different	different	JJ
cord-000248-zueoyesj	1231	49	degrees	degree	NNS
cord-000248-zueoyesj	1231	50	of	of	IN
cord-000248-zueoyesj	1231	51	malignancy	malignancy	NN
cord-000248-zueoyesj	1231	52	PSF	psf	NN
cord-000248-zueoyesj	1231	53	and	and	CC
cord-000248-zueoyesj	1231	54	p54(nrb)/NonO	p54(nrb)/NonO	NNP
cord-000248-zueoyesj	1231	55	-	-	HYPH
cord-000248-zueoyesj	1231	56	multi	multi	JJ
cord-000248-zueoyesj	1231	57	-	-	JJ
cord-000248-zueoyesj	1231	58	functional	functional	JJ
cord-000248-zueoyesj	1231	59	nuclear	nuclear	JJ
cord-000248-zueoyesj	1231	60	proteins	protein	NNS
cord-000248-zueoyesj	1232	1	The	the	DT
cord-000248-zueoyesj	1232	2	PSF.p54nrb	PSF.p54nrb	NNP
cord-000248-zueoyesj	1232	3	complex	complex	NN
cord-000248-zueoyesj	1232	4	is	be	VBZ
cord-000248-zueoyesj	1232	5	a	a	DT
cord-000248-zueoyesj	1232	6	novel	novel	JJ
cord-000248-zueoyesj	1232	7	Mnk	Mnk	NNP
cord-000248-zueoyesj	1232	8	substrate	substrate	NN
cord-000248-zueoyesj	1232	9	that	that	WDT
cord-000248-zueoyesj	1232	10	binds	bind	VBZ
cord-000248-zueoyesj	1232	11	the	the	DT
cord-000248-zueoyesj	1232	12	mRNA	mrna	NN
cord-000248-zueoyesj	1232	13	for	for	IN
cord-000248-zueoyesj	1232	14	tumor	tumor	NN
cord-000248-zueoyesj	1232	15	necrosis	necrosis	NN
cord-000248-zueoyesj	1232	16	factor	factor	NN
cord-000248-zueoyesj	1232	17	alpha	alpha	NN
cord-000248-zueoyesj	1232	18	PTB	PTB	NNP
cord-000248-zueoyesj	1232	19	-	-	HYPH
cord-000248-zueoyesj	1232	20	associated	associate	VBN
cord-000248-zueoyesj	1232	21	splicing	splicing	NN
cord-000248-zueoyesj	1232	22	factor	factor	NN
cord-000248-zueoyesj	1232	23	regulates	regulate	VBZ
cord-000248-zueoyesj	1232	24	growth	growth	NN
cord-000248-zueoyesj	1232	25	factor	factor	NN
cord-000248-zueoyesj	1232	26	-	-	HYPH
cord-000248-zueoyesj	1232	27	stimulated	stimulate	VBN
cord-000248-zueoyesj	1232	28	gene	gene	NN
cord-000248-zueoyesj	1232	29	expression	expression	NN
cord-000248-zueoyesj	1232	30	in	in	IN
cord-000248-zueoyesj	1232	31	mammalian	mammalian	JJ
cord-000248-zueoyesj	1232	32	cells	cell	NNS
cord-000248-zueoyesj	1233	1	Transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1233	2	activity	activity	NN
cord-000248-zueoyesj	1233	3	of	of	IN
cord-000248-zueoyesj	1233	4	androgen	androgen	NN
cord-000248-zueoyesj	1233	5	receptor	receptor	NN
cord-000248-zueoyesj	1233	6	is	be	VBZ
cord-000248-zueoyesj	1233	7	modulated	modulate	VBN
cord-000248-zueoyesj	1233	8	by	by	IN
cord-000248-zueoyesj	1233	9	two	two	CD
cord-000248-zueoyesj	1233	10	RNA	RNA	NNP
cord-000248-zueoyesj	1233	11	splicing	splicing	NN
cord-000248-zueoyesj	1233	12	factors	factor	NNS
cord-000248-zueoyesj	1233	13	,	,	,
cord-000248-zueoyesj	1233	14	PSF	psf	NN
cord-000248-zueoyesj	1233	15	and	and	CC
cord-000248-zueoyesj	1233	16	p54nrb	p54nrb	NNP
cord-000248-zueoyesj	1233	17	PSPC1	PSPC1	NNP
cord-000248-zueoyesj	1233	18	,	,	,
cord-000248-zueoyesj	1233	19	NONO	nono	UH
cord-000248-zueoyesj	1233	20	,	,	,
cord-000248-zueoyesj	1233	21	and	and	CC
cord-000248-zueoyesj	1233	22	SFPQ	SFPQ	NNP
cord-000248-zueoyesj	1233	23	are	be	VBP
cord-000248-zueoyesj	1233	24	expressed	express	VBN
cord-000248-zueoyesj	1233	25	in	in	IN
cord-000248-zueoyesj	1233	26	mouse	mouse	NN
cord-000248-zueoyesj	1233	27	Sertoli	Sertoli	NNP
cord-000248-zueoyesj	1233	28	cells	cell	NNS
cord-000248-zueoyesj	1233	29	and	and	CC
cord-000248-zueoyesj	1233	30	may	may	MD
cord-000248-zueoyesj	1233	31	function	function	VB
cord-000248-zueoyesj	1233	32	as	as	IN
cord-000248-zueoyesj	1233	33	coregulators	coregulator	NNS
cord-000248-zueoyesj	1233	34	of	of	IN
cord-000248-zueoyesj	1233	35	androgen	androgen	NN
cord-000248-zueoyesj	1233	36	receptor	receptor	NN
cord-000248-zueoyesj	1233	37	-	-	HYPH
cord-000248-zueoyesj	1233	38	mediated	mediate	VBN
cord-000248-zueoyesj	1233	39	transcription	transcription	NN
cord-000248-zueoyesj	1233	40	acts	act	NNS
cord-000248-zueoyesj	1233	41	as	as	IN
cord-000248-zueoyesj	1233	42	a	a	DT
cord-000248-zueoyesj	1233	43	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1233	44	coactivator	coactivator	NN
cord-000248-zueoyesj	1233	45	for	for	IN
cord-000248-zueoyesj	1233	46	activation	activation	NN
cord-000248-zueoyesj	1233	47	function	function	NN
cord-000248-zueoyesj	1233	48	1	1	CD
cord-000248-zueoyesj	1233	49	of	of	IN
cord-000248-zueoyesj	1233	50	the	the	DT
cord-000248-zueoyesj	1233	51	human	human	JJ
cord-000248-zueoyesj	1233	52	androgen	androgen	NN
cord-000248-zueoyesj	1233	53	receptor	receptor	NN
cord-000248-zueoyesj	1233	54	Regulation	Regulation	NNP
cord-000248-zueoyesj	1233	55	of	of	IN
cord-000248-zueoyesj	1233	56	RNA	RNA	NNP
cord-000248-zueoyesj	1233	57	-	-	HYPH
cord-000248-zueoyesj	1233	58	polymerase	polymerase	NNP
cord-000248-zueoyesj	1233	59	-	-	HYPH
cord-000248-zueoyesj	1233	60	II	ii	NN
cord-000248-zueoyesj	1233	61	-	-	HYPH
cord-000248-zueoyesj	1233	62	dependent	dependent	JJ
cord-000248-zueoyesj	1233	63	transcription	transcription	NN
cord-000248-zueoyesj	1233	64	by	by	IN
cord-000248-zueoyesj	1233	65	N	n	CD
cord-000248-zueoyesj	1233	66	-	-	HYPH
cord-000248-zueoyesj	1233	67	WASP	WASP	NNP
cord-000248-zueoyesj	1233	68	and	and	CC
cord-000248-zueoyesj	1233	69	its	-PRON-	PRP$
cord-000248-zueoyesj	1233	70	nuclearbinding	nuclearbinde	VBG
cord-000248-zueoyesj	1233	71	partners	partner	NNS
cord-000248-zueoyesj	1233	72	Identification	identification	NN
cord-000248-zueoyesj	1233	73	and	and	CC
cord-000248-zueoyesj	1233	74	characterization	characterization	NN
cord-000248-zueoyesj	1233	75	of	of	IN
cord-000248-zueoyesj	1233	76	the	the	DT
cord-000248-zueoyesj	1233	77	protein	protein	NN
cord-000248-zueoyesj	1233	78	-	-	HYPH
cord-000248-zueoyesj	1233	79	associated	associate	VBN
cord-000248-zueoyesj	1233	80	splicing	splicing	NN
cord-000248-zueoyesj	1233	81	factor	factor	NN
cord-000248-zueoyesj	1233	82	as	as	IN
cord-000248-zueoyesj	1233	83	a	a	DT
cord-000248-zueoyesj	1233	84	negative	negative	JJ
cord-000248-zueoyesj	1233	85	coregulator	coregulator	NN
cord-000248-zueoyesj	1233	86	of	of	IN
cord-000248-zueoyesj	1233	87	the	the	DT
cord-000248-zueoyesj	1233	88	progesterone	progesterone	NN
cord-000248-zueoyesj	1233	89	receptor	receptor	NN
cord-000248-zueoyesj	1233	90	Inhibition	Inhibition	NNP
cord-000248-zueoyesj	1233	91	of	of	IN
cord-000248-zueoyesj	1233	92	dendritic	dendritic	JJ
cord-000248-zueoyesj	1233	93	cell	cell	NN
cord-000248-zueoyesj	1233	94	generation	generation	NN
cord-000248-zueoyesj	1233	95	and	and	CC
cord-000248-zueoyesj	1233	96	function	function	NN
cord-000248-zueoyesj	1233	97	by	by	IN
cord-000248-zueoyesj	1233	98	serum	serum	NN
cord-000248-zueoyesj	1233	99	from	from	IN
cord-000248-zueoyesj	1233	100	prostate	prostate	NN
cord-000248-zueoyesj	1233	101	cancer	cancer	NN
cord-000248-zueoyesj	1233	102	patients	patient	NNS
cord-000248-zueoyesj	1233	103	:	:	:
cord-000248-zueoyesj	1233	104	correlation	correlation	NN
cord-000248-zueoyesj	1233	105	with	with	IN
cord-000248-zueoyesj	1233	106	serum	serum	NN
cord-000248-zueoyesj	1233	107	-	-	HYPH
cord-000248-zueoyesj	1233	108	free	free	JJ
cord-000248-zueoyesj	1233	109	PSA	PSA	NNP
cord-000248-zueoyesj	1233	110	Impact	Impact	NNP
cord-000248-zueoyesj	1233	111	of	of	IN
cord-000248-zueoyesj	1233	112	the	the	DT
cord-000248-zueoyesj	1233	113	tumor	tumor	NN
cord-000248-zueoyesj	1233	114	microenvironment	microenvironment	NN
cord-000248-zueoyesj	1233	115	on	on	IN
cord-000248-zueoyesj	1233	116	host	host	NN
cord-000248-zueoyesj	1233	117	infiltrating	infiltrate	VBG
cord-000248-zueoyesj	1233	118	cells	cell	NNS
cord-000248-zueoyesj	1233	119	and	and	CC
cord-000248-zueoyesj	1233	120	the	the	DT
cord-000248-zueoyesj	1233	121	efficacy	efficacy	NN
cord-000248-zueoyesj	1233	122	of	of	IN
cord-000248-zueoyesj	1233	123	flt3-ligand	flt3-ligand	NNP
cord-000248-zueoyesj	1233	124	combination	combination	NN
cord-000248-zueoyesj	1233	125	immunotherapy	immunotherapy	NN
cord-000248-zueoyesj	1233	126	evaluated	evaluate	VBN
cord-000248-zueoyesj	1233	127	in	in	IN
cord-000248-zueoyesj	1233	128	a	a	DT
cord-000248-zueoyesj	1233	129	treatment	treatment	NN
cord-000248-zueoyesj	1233	130	model	model	NN
cord-000248-zueoyesj	1233	131	of	of	IN
cord-000248-zueoyesj	1233	132	mouse	mouse	NN
cord-000248-zueoyesj	1233	133	prostate	prostate	NN
cord-000248-zueoyesj	1233	134	cancer	cancer	NN
cord-000248-zueoyesj	1233	135	Prostate	Prostate	NNP
cord-000248-zueoyesj	1233	136	tumor	tumor	NN
cord-000248-zueoyesj	1233	137	microenvironment	microenvironment	NN
cord-000248-zueoyesj	1233	138	alters	alter	VBZ
cord-000248-zueoyesj	1233	139	immune	immune	JJ
cord-000248-zueoyesj	1233	140	cells	cell	NNS
cord-000248-zueoyesj	1233	141	and	and	CC
cord-000248-zueoyesj	1233	142	prevents	prevent	VBZ
cord-000248-zueoyesj	1233	143	long	long	JJ
cord-000248-zueoyesj	1233	144	-	-	HYPH
cord-000248-zueoyesj	1233	145	term	term	NN
cord-000248-zueoyesj	1233	146	survival	survival	NN
cord-000248-zueoyesj	1233	147	in	in	IN
cord-000248-zueoyesj	1233	148	an	an	DT
cord-000248-zueoyesj	1233	149	orthotopic	orthotopic	JJ
cord-000248-zueoyesj	1233	150	mouse	mouse	NN
cord-000248-zueoyesj	1233	151	model	model	NN
cord-000248-zueoyesj	1233	152	following	follow	VBG
cord-000248-zueoyesj	1233	153	flt3-ligand	flt3-ligand	NNP
cord-000248-zueoyesj	1233	154	/	/	,
cord-000248-zueoyesj	1233	155	CD40-ligand	CD40-ligand	NNP
cord-000248-zueoyesj	1233	156	immunotherapy	immunotherapy	NN
cord-000248-zueoyesj	1234	1	The	the	DT
cord-000248-zueoyesj	1234	2	influence	influence	NN
cord-000248-zueoyesj	1234	3	of	of	IN
cord-000248-zueoyesj	1234	4	alpha1-antagonist	alpha1-antagonist	NN
cord-000248-zueoyesj	1234	5	on	on	IN
cord-000248-zueoyesj	1234	6	the	the	DT
cord-000248-zueoyesj	1234	7	expression	expression	NN
cord-000248-zueoyesj	1234	8	pattern	pattern	NN
cord-000248-zueoyesj	1234	9	of	of	IN
cord-000248-zueoyesj	1234	10	TNF	TNF	NNP
cord-000248-zueoyesj	1234	11	receptor	receptor	NN
cord-000248-zueoyesj	1234	12	family	family	NN
cord-000248-zueoyesj	1234	13	in	in	IN
cord-000248-zueoyesj	1234	14	primary	primary	JJ
cord-000248-zueoyesj	1234	15	culture	culture	NN
cord-000248-zueoyesj	1234	16	of	of	IN
cord-000248-zueoyesj	1234	17	prostate	prostate	NN
cord-000248-zueoyesj	1234	18	epithelial	epithelial	JJ
cord-000248-zueoyesj	1234	19	cells	cell	NNS
cord-000248-zueoyesj	1234	20	from	from	IN
cord-000248-zueoyesj	1234	21	BPH	BPH	NNP
cord-000248-zueoyesj	1234	22	patients	patient	NNS
cord-000248-zueoyesj	1235	1	Adenovirus	Adenovirus	NNP
cord-000248-zueoyesj	1235	2	-	-	HYPH
cord-000248-zueoyesj	1235	3	mediated	mediate	VBN
cord-000248-zueoyesj	1235	4	CD40	CD40	NNP
cord-000248-zueoyesj	1235	5	ligand	ligand	NN
cord-000248-zueoyesj	1235	6	therapy	therapy	NN
cord-000248-zueoyesj	1235	7	induces	induce	VBZ
cord-000248-zueoyesj	1235	8	tumor	tumor	NN
cord-000248-zueoyesj	1235	9	cell	cell	NN
cord-000248-zueoyesj	1235	10	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1235	11	and	and	CC
cord-000248-zueoyesj	1235	12	systemic	systemic	JJ
cord-000248-zueoyesj	1235	13	immunity	immunity	NN
cord-000248-zueoyesj	1235	14	in	in	IN
cord-000248-zueoyesj	1235	15	the	the	DT
cord-000248-zueoyesj	1235	16	TRAMP	tramp	NN
cord-000248-zueoyesj	1235	17	-	-	HYPH
cord-000248-zueoyesj	1235	18	C2	c2	NN
cord-000248-zueoyesj	1235	19	mouse	mouse	NN
cord-000248-zueoyesj	1235	20	prostate	prostate	NN
cord-000248-zueoyesj	1235	21	cancer	cancer	NN
cord-000248-zueoyesj	1235	22	model	model	NN
cord-000248-zueoyesj	1235	23	Avoiding	avoid	VBG
cord-000248-zueoyesj	1235	24	Tolerance	tolerance	NN
cord-000248-zueoyesj	1235	25	Against	against	IN
cord-000248-zueoyesj	1235	26	Prostatic	Prostatic	NNP
cord-000248-zueoyesj	1235	27	Antigens	Antigens	NNP
cord-000248-zueoyesj	1235	28	With	with	IN
cord-000248-zueoyesj	1235	29	Subdominant	Subdominant	NNP
cord-000248-zueoyesj	1235	30	Peptide	Peptide	NNP
cord-000248-zueoyesj	1235	31	Epitopes	Epitopes	NNP
cord-000248-zueoyesj	1235	32	Avoiding	avoid	VBG
cord-000248-zueoyesj	1235	33	tolerance	tolerance	NN
cord-000248-zueoyesj	1235	34	against	against	IN
cord-000248-zueoyesj	1235	35	prostatic	prostatic	JJ
cord-000248-zueoyesj	1235	36	antigens	antigen	NNS
cord-000248-zueoyesj	1235	37	with	with	IN
cord-000248-zueoyesj	1235	38	subdominant	subdominant	JJ
cord-000248-zueoyesj	1235	39	peptide	peptide	NN
cord-000248-zueoyesj	1235	40	epitopes	epitope	NNS
cord-000248-zueoyesj	1235	41	Plasma	plasma	NN
cord-000248-zueoyesj	1235	42	tissue	tissue	NN
cord-000248-zueoyesj	1235	43	factor	factor	NN
cord-000248-zueoyesj	1235	44	antigen	antigen	NN
cord-000248-zueoyesj	1235	45	in	in	IN
cord-000248-zueoyesj	1235	46	localized	localized	JJ
cord-000248-zueoyesj	1235	47	prostate	prostate	NN
cord-000248-zueoyesj	1235	48	cancer	cancer	NN
cord-000248-zueoyesj	1235	49	:	:	:
cord-000248-zueoyesj	1235	50	distribution	distribution	NN
cord-000248-zueoyesj	1235	51	,	,	,
cord-000248-zueoyesj	1235	52	clinical	clinical	JJ
cord-000248-zueoyesj	1235	53	significance	significance	NN
cord-000248-zueoyesj	1235	54	and	and	CC
cord-000248-zueoyesj	1235	55	correlation	correlation	NN
cord-000248-zueoyesj	1235	56	with	with	IN
cord-000248-zueoyesj	1235	57	haemostatic	haemostatic	JJ
cord-000248-zueoyesj	1235	58	activation	activation	NN
cord-000248-zueoyesj	1235	59	markers	marker	NNS
cord-000248-zueoyesj	1235	60	Enhanced	enhanced	JJ
cord-000248-zueoyesj	1235	61	activation	activation	NN
cord-000248-zueoyesj	1235	62	of	of	IN
cord-000248-zueoyesj	1235	63	human	human	JJ
cord-000248-zueoyesj	1235	64	dendritic	dendritic	JJ
cord-000248-zueoyesj	1235	65	cells	cell	NNS
cord-000248-zueoyesj	1235	66	by	by	IN
cord-000248-zueoyesj	1235	67	inducible	inducible	JJ
cord-000248-zueoyesj	1236	1	CD40	CD40	NNP
cord-000248-zueoyesj	1236	2	and	and	CC
cord-000248-zueoyesj	1236	3	Toll	Toll	NNP
cord-000248-zueoyesj	1236	4	-	-	HYPH
cord-000248-zueoyesj	1236	5	like	like	JJ
cord-000248-zueoyesj	1236	6	receptor-4	receptor-4	NNP
cord-000248-zueoyesj	1236	7	ligation	ligation	NN
cord-000248-zueoyesj	1237	1	Mature	mature	JJ
cord-000248-zueoyesj	1237	2	dendritic	dendritic	JJ
cord-000248-zueoyesj	1237	3	cells	cell	NNS
cord-000248-zueoyesj	1237	4	induce	induce	VBP
cord-000248-zueoyesj	1237	5	tumor	tumor	NN
cord-000248-zueoyesj	1237	6	-	-	HYPH
cord-000248-zueoyesj	1237	7	specific	specific	JJ
cord-000248-zueoyesj	1237	8	type	type	NN
cord-000248-zueoyesj	1237	9	1	1	CD
cord-000248-zueoyesj	1237	10	regulatory	regulatory	JJ
cord-000248-zueoyesj	1237	11	T	t	NN
cord-000248-zueoyesj	1237	12	cells	cell	NNS
cord-000248-zueoyesj	1238	1	CD40	CD40	NNP
cord-000248-zueoyesj	1238	2	is	be	VBZ
cord-000248-zueoyesj	1238	3	not	not	RB
cord-000248-zueoyesj	1238	4	detected	detect	VBN
cord-000248-zueoyesj	1238	5	on	on	IN
cord-000248-zueoyesj	1238	6	human	human	JJ
cord-000248-zueoyesj	1238	7	prostate	prostate	NN
cord-000248-zueoyesj	1238	8	cancer	cancer	NN
cord-000248-zueoyesj	1238	9	cells	cell	NNS
cord-000248-zueoyesj	1238	10	by	by	IN
cord-000248-zueoyesj	1238	11	immunohistologic	immunohistologic	NN
cord-000248-zueoyesj	1238	12	techniques	technique	NNS
cord-000248-zueoyesj	1239	1	Flt3	flt3	NN
cord-000248-zueoyesj	1239	2	ligand	ligand	NN
cord-000248-zueoyesj	1239	3	expands	expand	VBZ
cord-000248-zueoyesj	1239	4	dendritic	dendritic	JJ
cord-000248-zueoyesj	1239	5	cell	cell	NN
cord-000248-zueoyesj	1239	6	numbers	number	NNS
cord-000248-zueoyesj	1239	7	in	in	IN
cord-000248-zueoyesj	1239	8	normal	normal	JJ
cord-000248-zueoyesj	1239	9	and	and	CC
cord-000248-zueoyesj	1239	10	malignant	malignant	JJ
cord-000248-zueoyesj	1239	11	murine	murine	JJ
cord-000248-zueoyesj	1239	12	prostate	prostate	NN
cord-000248-zueoyesj	1239	13	Functional	functional	JJ
cord-000248-zueoyesj	1239	14	dichotomy	dichotomy	NN
cord-000248-zueoyesj	1239	15	in	in	IN
cord-000248-zueoyesj	1239	16	CD40	CD40	NNP
cord-000248-zueoyesj	1239	17	reciprocally	reciprocally	RB
cord-000248-zueoyesj	1239	18	regulates	regulate	VBZ
cord-000248-zueoyesj	1239	19	effector	effector	NN
cord-000248-zueoyesj	1239	20	T	t	NN
cord-000248-zueoyesj	1239	21	cell	cell	NN
cord-000248-zueoyesj	1239	22	functions	function	NNS
cord-000248-zueoyesj	1239	23	Dendritic	dendritic	JJ
cord-000248-zueoyesj	1239	24	cell	cell	NN
cord-000248-zueoyesj	1239	25	gene	gene	NN
cord-000248-zueoyesj	1239	26	therapy	therapy	NN
cord-000248-zueoyesj	1240	1	CD40	cd40	JJ
cord-000248-zueoyesj	1240	2	expression	expression	NN
cord-000248-zueoyesj	1240	3	in	in	IN
cord-000248-zueoyesj	1240	4	prostate	prostate	NN
cord-000248-zueoyesj	1240	5	cancer	cancer	NN
cord-000248-zueoyesj	1240	6	:	:	:
cord-000248-zueoyesj	1240	7	a	a	DT
cord-000248-zueoyesj	1240	8	potential	potential	JJ
cord-000248-zueoyesj	1240	9	diagnostic	diagnostic	JJ
cord-000248-zueoyesj	1240	10	and	and	CC
cord-000248-zueoyesj	1240	11	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1240	12	molecule	molecule	NN
cord-000248-zueoyesj	1240	13	A	a	DT
cord-000248-zueoyesj	1240	14	population	population	NN
cord-000248-zueoyesj	1240	15	of	of	IN
cord-000248-zueoyesj	1240	16	HLA	HLA	NNP
cord-000248-zueoyesj	1240	17	-	-	HYPH
cord-000248-zueoyesj	1240	18	DR+	DR+	NNP
cord-000248-zueoyesj	1240	19	immature	immature	JJ
cord-000248-zueoyesj	1240	20	cells	cell	NNS
cord-000248-zueoyesj	1240	21	accumulates	accumulate	VBZ
cord-000248-zueoyesj	1240	22	in	in	IN
cord-000248-zueoyesj	1240	23	the	the	DT
cord-000248-zueoyesj	1240	24	blood	blood	NN
cord-000248-zueoyesj	1240	25	dendritic	dendritic	JJ
cord-000248-zueoyesj	1240	26	cell	cell	NN
cord-000248-zueoyesj	1240	27	compartment	compartment	NN
cord-000248-zueoyesj	1240	28	of	of	IN
cord-000248-zueoyesj	1240	29	patients	patient	NNS
cord-000248-zueoyesj	1240	30	with	with	IN
cord-000248-zueoyesj	1240	31	different	different	JJ
cord-000248-zueoyesj	1240	32	types	type	NNS
cord-000248-zueoyesj	1240	33	of	of	IN
cord-000248-zueoyesj	1240	34	cancer	cancer	NN
cord-000248-zueoyesj	1240	35	Cytokine	cytokine	NN
cord-000248-zueoyesj	1240	36	-	-	HYPH
cord-000248-zueoyesj	1240	37	mediated	mediate	VBN
cord-000248-zueoyesj	1240	38	protection	protection	NN
cord-000248-zueoyesj	1240	39	of	of	IN
cord-000248-zueoyesj	1240	40	human	human	JJ
cord-000248-zueoyesj	1240	41	dendritic	dendritic	JJ
cord-000248-zueoyesj	1240	42	cells	cell	NNS
cord-000248-zueoyesj	1240	43	from	from	IN
cord-000248-zueoyesj	1240	44	prostate	prostate	NN
cord-000248-zueoyesj	1240	45	cancerinduced	cancerinduce	VBN
cord-000248-zueoyesj	1240	46	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1240	47	is	be	VBZ
cord-000248-zueoyesj	1240	48	regulated	regulate	VBN
cord-000248-zueoyesj	1240	49	by	by	IN
cord-000248-zueoyesj	1240	50	the	the	DT
cord-000248-zueoyesj	1240	51	Bcl-2	Bcl-2	NNP
cord-000248-zueoyesj	1240	52	family	family	NN
cord-000248-zueoyesj	1240	53	of	of	IN
cord-000248-zueoyesj	1240	54	proteins	protein	NNS
cord-000248-zueoyesj	1240	55	Fas	Fas	NNP
cord-000248-zueoyesj	1240	56	-	-	HYPH
cord-000248-zueoyesj	1240	57	mediated	mediate	VBN
cord-000248-zueoyesj	1240	58	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1240	59	in	in	IN
cord-000248-zueoyesj	1240	60	human	human	JJ
cord-000248-zueoyesj	1240	61	prostatic	prostatic	JJ
cord-000248-zueoyesj	1240	62	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1240	63	cell	cell	NN
cord-000248-zueoyesj	1240	64	lines	line	NNS
cord-000248-zueoyesj	1240	65	Increased	increase	VBN
cord-000248-zueoyesj	1240	66	function	function	NN
cord-000248-zueoyesj	1240	67	and	and	CC
cord-000248-zueoyesj	1240	68	survival	survival	NN
cord-000248-zueoyesj	1240	69	of	of	IN
cord-000248-zueoyesj	1240	70	IL-15-transduced	il-15-transduced	NN
cord-000248-zueoyesj	1240	71	human	human	JJ
cord-000248-zueoyesj	1240	72	dendritic	dendritic	JJ
cord-000248-zueoyesj	1240	73	cells	cell	NNS
cord-000248-zueoyesj	1240	74	are	be	VBP
cord-000248-zueoyesj	1240	75	mediated	mediate	VBN
cord-000248-zueoyesj	1240	76	by	by	IN
cord-000248-zueoyesj	1240	77	up	up	IN
cord-000248-zueoyesj	1240	78	-	-	HYPH
cord-000248-zueoyesj	1240	79	regulation	regulation	NN
cord-000248-zueoyesj	1240	80	of	of	IN
cord-000248-zueoyesj	1240	81	IL-15Ralpha	IL-15Ralpha	NNP
cord-000248-zueoyesj	1240	82	and	and	CC
cord-000248-zueoyesj	1240	83	Bcl-2	Bcl-2	NNP
cord-000248-zueoyesj	1240	84	Expression	expression	NN
cord-000248-zueoyesj	1240	85	and	and	CC
cord-000248-zueoyesj	1240	86	function	function	NN
cord-000248-zueoyesj	1240	87	of	of	IN
cord-000248-zueoyesj	1240	88	the	the	DT
cord-000248-zueoyesj	1240	89	complement	complement	JJ
cord-000248-zueoyesj	1240	90	membrane	membrane	NN
cord-000248-zueoyesj	1240	91	attack	attack	NN
cord-000248-zueoyesj	1240	92	complex	complex	JJ
cord-000248-zueoyesj	1240	93	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1240	94	protectin	protectin	NNP
cord-000248-zueoyesj	1240	95	(	(	-LRB-
cord-000248-zueoyesj	1240	96	CD59	CD59	NNP
cord-000248-zueoyesj	1240	97	)	)	-RRB-
cord-000248-zueoyesj	1240	98	in	in	IN
cord-000248-zueoyesj	1240	99	human	human	JJ
cord-000248-zueoyesj	1240	100	prostate	prostate	NN
cord-000248-zueoyesj	1240	101	cancer	cancer	NN
cord-000248-zueoyesj	1240	102	Increased	increase	VBD
cord-000248-zueoyesj	1240	103	CD59	CD59	NNP
cord-000248-zueoyesj	1240	104	protein	protein	NN
cord-000248-zueoyesj	1240	105	expression	expression	NN
cord-000248-zueoyesj	1240	106	predicts	predict	VBZ
cord-000248-zueoyesj	1240	107	a	a	DT
cord-000248-zueoyesj	1240	108	PSA	PSA	NNP
cord-000248-zueoyesj	1240	109	relapse	relapse	NN
cord-000248-zueoyesj	1240	110	in	in	IN
cord-000248-zueoyesj	1240	111	patients	patient	NNS
cord-000248-zueoyesj	1240	112	after	after	IN
cord-000248-zueoyesj	1240	113	radical	radical	JJ
cord-000248-zueoyesj	1240	114	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1240	115	Differential	differential	JJ
cord-000248-zueoyesj	1240	116	expression	expression	NN
cord-000248-zueoyesj	1240	117	of	of	IN
cord-000248-zueoyesj	1240	118	complement	complement	JJ
cord-000248-zueoyesj	1240	119	regulatory	regulatory	JJ
cord-000248-zueoyesj	1240	120	proteins	protein	NNS
cord-000248-zueoyesj	1240	121	decay	decay	VB
cord-000248-zueoyesj	1240	122	-	-	HYPH
cord-000248-zueoyesj	1240	123	accelerating	accelerate	VBG
cord-000248-zueoyesj	1240	124	factor	factor	NN
cord-000248-zueoyesj	1240	125	(	(	-LRB-
cord-000248-zueoyesj	1240	126	CD55	CD55	NNP
cord-000248-zueoyesj	1240	127	)	)	-RRB-
cord-000248-zueoyesj	1240	128	,	,	,
cord-000248-zueoyesj	1240	129	membrane	membrane	NN
cord-000248-zueoyesj	1240	130	cofactor	cofactor	NN
cord-000248-zueoyesj	1240	131	protein	protein	NN
cord-000248-zueoyesj	1240	132	(	(	-LRB-
cord-000248-zueoyesj	1240	133	CD46	CD46	NNP
cord-000248-zueoyesj	1240	134	)	)	-RRB-
cord-000248-zueoyesj	1240	135	and	and	CC
cord-000248-zueoyesj	1240	136	CD59	CD59	NNP
cord-000248-zueoyesj	1240	137	during	during	IN
cord-000248-zueoyesj	1240	138	human	human	JJ
cord-000248-zueoyesj	1240	139	spermatogenesis	spermatogenesis	NN
cord-000248-zueoyesj	1240	140	Flow	flow	NN
cord-000248-zueoyesj	1240	141	cytometric	cytometric	NN
cord-000248-zueoyesj	1240	142	technique	technique	NN
cord-000248-zueoyesj	1240	143	for	for	IN
cord-000248-zueoyesj	1240	144	determination	determination	NN
cord-000248-zueoyesj	1240	145	of	of	IN
cord-000248-zueoyesj	1240	146	prostasomal	prostasomal	JJ
cord-000248-zueoyesj	1240	147	quantity	quantity	NN
cord-000248-zueoyesj	1240	148	,	,	,
cord-000248-zueoyesj	1240	149	size	size	NN
cord-000248-zueoyesj	1240	150	and	and	CC
cord-000248-zueoyesj	1240	151	expression	expression	NN
cord-000248-zueoyesj	1240	152	of	of	IN
cord-000248-zueoyesj	1240	153	CD10	CD10	NNP
cord-000248-zueoyesj	1240	154	,	,	,
cord-000248-zueoyesj	1240	155	CD13	CD13	NNP
cord-000248-zueoyesj	1240	156	,	,	,
cord-000248-zueoyesj	1240	157	CD26	CD26	NNP
cord-000248-zueoyesj	1240	158	and	and	CC
cord-000248-zueoyesj	1240	159	CD59	CD59	NNP
cord-000248-zueoyesj	1240	160	in	in	IN
cord-000248-zueoyesj	1240	161	human	human	JJ
cord-000248-zueoyesj	1240	162	seminal	seminal	JJ
cord-000248-zueoyesj	1240	163	plasma	plasma	NN
cord-000248-zueoyesj	1240	164	Transfer	transfer	NN
cord-000248-zueoyesj	1240	165	of	of	IN
cord-000248-zueoyesj	1240	166	prostasomal	prostasomal	NNP
cord-000248-zueoyesj	1240	167	CD59	CD59	NNP
cord-000248-zueoyesj	1240	168	to	to	IN
cord-000248-zueoyesj	1240	169	CD59-deficient	cd59-deficient	CD
cord-000248-zueoyesj	1240	170	red	red	JJ
cord-000248-zueoyesj	1240	171	blood	blood	NN
cord-000248-zueoyesj	1240	172	cells	cell	NNS
cord-000248-zueoyesj	1240	173	results	result	NNS
cord-000248-zueoyesj	1240	174	in	in	IN
cord-000248-zueoyesj	1240	175	protection	protection	NN
cord-000248-zueoyesj	1240	176	against	against	IN
cord-000248-zueoyesj	1240	177	complement	complement	NN
cord-000248-zueoyesj	1240	178	-	-	HYPH
cord-000248-zueoyesj	1240	179	mediated	mediate	VBN
cord-000248-zueoyesj	1240	180	hemolysis	hemolysis	NN
cord-000248-zueoyesj	1240	181	Identification	identification	NN
cord-000248-zueoyesj	1240	182	of	of	IN
cord-000248-zueoyesj	1240	183	extracellular	extracellular	JJ
cord-000248-zueoyesj	1240	184	delta	delta	NN
cord-000248-zueoyesj	1240	185	-	-	HYPH
cord-000248-zueoyesj	1240	186	catenin	catenin	NN
cord-000248-zueoyesj	1240	187	accumulation	accumulation	NN
cord-000248-zueoyesj	1240	188	for	for	IN
cord-000248-zueoyesj	1240	189	prostate	prostate	NN
cord-000248-zueoyesj	1240	190	cancer	cancer	NN
cord-000248-zueoyesj	1240	191	detection	detection	NN
cord-000248-zueoyesj	1241	1	Possible	possible	JJ
cord-000248-zueoyesj	1241	2	immunoprotective	immunoprotective	JJ
cord-000248-zueoyesj	1241	3	and	and	CC
cord-000248-zueoyesj	1241	4	angiogenesis	angiogenesis	NN
cord-000248-zueoyesj	1241	5	-	-	HYPH
cord-000248-zueoyesj	1241	6	promoting	promote	VBG
cord-000248-zueoyesj	1241	7	roles	role	NNS
cord-000248-zueoyesj	1241	8	for	for	IN
cord-000248-zueoyesj	1241	9	malignant	malignant	JJ
cord-000248-zueoyesj	1241	10	cell	cell	NN
cord-000248-zueoyesj	1241	11	-	-	HYPH
cord-000248-zueoyesj	1241	12	derived	derive	VBN
cord-000248-zueoyesj	1241	13	prostasomes	prostasome	NNS
cord-000248-zueoyesj	1241	14	:	:	:
cord-000248-zueoyesj	1241	15	a	a	DT
cord-000248-zueoyesj	1241	16	new	new	JJ
cord-000248-zueoyesj	1241	17	paradigm	paradigm	NN
cord-000248-zueoyesj	1241	18	for	for	IN
cord-000248-zueoyesj	1241	19	prostatic	prostatic	JJ
cord-000248-zueoyesj	1241	20	cancer	cancer	NN
cord-000248-zueoyesj	1241	21	?	?	.
cord-000248-zueoyesj	1242	1	Complement	complement	JJ
cord-000248-zueoyesj	1242	2	resistance	resistance	NN
cord-000248-zueoyesj	1242	3	of	of	IN
cord-000248-zueoyesj	1242	4	human	human	JJ
cord-000248-zueoyesj	1242	5	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1242	6	cells	cell	NNS
cord-000248-zueoyesj	1242	7	depends	depend	VBZ
cord-000248-zueoyesj	1242	8	on	on	IN
cord-000248-zueoyesj	1242	9	membrane	membrane	NN
cord-000248-zueoyesj	1242	10	regulatory	regulatory	JJ
cord-000248-zueoyesj	1242	11	proteins	protein	NNS
cord-000248-zueoyesj	1242	12	,	,	,
cord-000248-zueoyesj	1242	13	protein	protein	NN
cord-000248-zueoyesj	1242	14	kinases	kinase	NNS
cord-000248-zueoyesj	1242	15	and	and	CC
cord-000248-zueoyesj	1242	16	sialic	sialic	NN
cord-000248-zueoyesj	1242	17	acid	acid	NN
cord-000248-zueoyesj	1243	1	The	the	DT
cord-000248-zueoyesj	1243	2	nuclear	nuclear	JJ
cord-000248-zueoyesj	1243	3	lamina	lamina	NN
cord-000248-zueoyesj	1243	4	.	.	.
cord-000248-zueoyesj	1244	1	Both	both	CC
cord-000248-zueoyesj	1244	2	a	a	DT
cord-000248-zueoyesj	1244	3	structural	structural	JJ
cord-000248-zueoyesj	1244	4	framework	framework	NN
cord-000248-zueoyesj	1244	5	and	and	CC
cord-000248-zueoyesj	1244	6	a	a	DT
cord-000248-zueoyesj	1244	7	platform	platform	NN
cord-000248-zueoyesj	1244	8	for	for	IN
cord-000248-zueoyesj	1244	9	genome	genome	NN
cord-000248-zueoyesj	1244	10	organization	organization	NN
cord-000248-zueoyesj	1245	1	The	the	DT
cord-000248-zueoyesj	1245	2	nuclear	nuclear	JJ
cord-000248-zueoyesj	1245	3	envelope	envelope	NN
cord-000248-zueoyesj	1245	4	,	,	,
cord-000248-zueoyesj	1245	5	a	a	DT
cord-000248-zueoyesj	1245	6	key	key	JJ
cord-000248-zueoyesj	1245	7	structure	structure	NN
cord-000248-zueoyesj	1245	8	in	in	IN
cord-000248-zueoyesj	1245	9	cellular	cellular	JJ
cord-000248-zueoyesj	1245	10	integrity	integrity	NN
cord-000248-zueoyesj	1245	11	and	and	CC
cord-000248-zueoyesj	1245	12	gene	gene	NN
cord-000248-zueoyesj	1245	13	expression	expression	NN
cord-000248-zueoyesj	1245	14	Mouse	Mouse	NNP
cord-000248-zueoyesj	1245	15	models	model	NNS
cord-000248-zueoyesj	1245	16	of	of	IN
cord-000248-zueoyesj	1245	17	the	the	DT
cord-000248-zueoyesj	1245	18	laminopathies	laminopathies	NNP
cord-000248-zueoyesj	1245	19	Laminopathies	Laminopathies	NNP
cord-000248-zueoyesj	1245	20	'	'	POS
cord-000248-zueoyesj	1245	21	'	'	''
cord-000248-zueoyesj	1245	22	:	:	:
cord-000248-zueoyesj	1245	23	a	a	DT
cord-000248-zueoyesj	1245	24	wide	wide	JJ
cord-000248-zueoyesj	1245	25	spectrum	spectrum	NN
cord-000248-zueoyesj	1245	26	of	of	IN
cord-000248-zueoyesj	1245	27	human	human	JJ
cord-000248-zueoyesj	1245	28	diseases	disease	NNS
cord-000248-zueoyesj	1245	29	Phenomics	phenomic	NNS
cord-000248-zueoyesj	1245	30	and	and	CC
cord-000248-zueoyesj	1245	31	lamins	lamin	NNS
cord-000248-zueoyesj	1245	32	:	:	:
cord-000248-zueoyesj	1245	33	from	from	IN
cord-000248-zueoyesj	1245	34	disease	disease	NN
cord-000248-zueoyesj	1245	35	to	to	IN
cord-000248-zueoyesj	1245	36	therapy	therapy	NN
cord-000248-zueoyesj	1245	37	Adult	adult	NN
cord-000248-zueoyesj	1245	38	stem	stem	NN
cord-000248-zueoyesj	1245	39	cell	cell	NN
cord-000248-zueoyesj	1245	40	maintenance	maintenance	NN
cord-000248-zueoyesj	1245	41	and	and	CC
cord-000248-zueoyesj	1245	42	tissue	tissue	NN
cord-000248-zueoyesj	1245	43	regeneration	regeneration	NN
cord-000248-zueoyesj	1245	44	in	in	IN
cord-000248-zueoyesj	1245	45	the	the	DT
cord-000248-zueoyesj	1245	46	ageing	age	VBG
cord-000248-zueoyesj	1245	47	context	context	NN
cord-000248-zueoyesj	1245	48	:	:	:
cord-000248-zueoyesj	1245	49	the	the	DT
cord-000248-zueoyesj	1245	50	role	role	NN
cord-000248-zueoyesj	1245	51	for	for	IN
cord-000248-zueoyesj	1245	52	A	a	DT
cord-000248-zueoyesj	1245	53	-	-	HYPH
cord-000248-zueoyesj	1245	54	type	type	NN
cord-000248-zueoyesj	1245	55	lamins	lamin	NNS
cord-000248-zueoyesj	1245	56	as	as	IN
cord-000248-zueoyesj	1245	57	intrinsic	intrinsic	JJ
cord-000248-zueoyesj	1245	58	modulators	modulator	NNS
cord-000248-zueoyesj	1245	59	of	of	IN
cord-000248-zueoyesj	1245	60	ageing	age	VBG
cord-000248-zueoyesj	1245	61	in	in	IN
cord-000248-zueoyesj	1245	62	adult	adult	NN
cord-000248-zueoyesj	1245	63	stem	stem	NN
cord-000248-zueoyesj	1245	64	cells	cell	NNS
cord-000248-zueoyesj	1245	65	and	and	CC
cord-000248-zueoyesj	1245	66	their	-PRON-	PRP$
cord-000248-zueoyesj	1245	67	niches	niche	NNS
cord-000248-zueoyesj	1245	68	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1245	69	lamin	lamin	NN
cord-000248-zueoyesj	1245	70	A	A	NNP
cord-000248-zueoyesj	1245	71	/	/	SYM
cord-000248-zueoyesj	1245	72	C	C	NNP
cord-000248-zueoyesj	1245	73	deficiency	deficiency	NN
cord-000248-zueoyesj	1245	74	induces	induce	VBZ
cord-000248-zueoyesj	1245	75	defects	defect	NNS
cord-000248-zueoyesj	1245	76	in	in	IN
cord-000248-zueoyesj	1245	77	cell	cell	NN
cord-000248-zueoyesj	1245	78	mechanics	mechanic	NNS
cord-000248-zueoyesj	1245	79	,	,	,
cord-000248-zueoyesj	1245	80	polarization	polarization	NN
cord-000248-zueoyesj	1245	81	,	,	,
cord-000248-zueoyesj	1245	82	and	and	CC
cord-000248-zueoyesj	1245	83	migration	migration	NN
cord-000248-zueoyesj	1245	84	Lamin	Lamin	NNP
cord-000248-zueoyesj	1245	85	A	A	NNP
cord-000248-zueoyesj	1245	86	/	/	SYM
cord-000248-zueoyesj	1245	87	C	C	NNP
cord-000248-zueoyesj	1245	88	deficiency	deficiency	NN
cord-000248-zueoyesj	1245	89	causes	cause	VBZ
cord-000248-zueoyesj	1245	90	defective	defective	JJ
cord-000248-zueoyesj	1245	91	nuclear	nuclear	JJ
cord-000248-zueoyesj	1245	92	mechanics	mechanic	NNS
cord-000248-zueoyesj	1245	93	and	and	CC
cord-000248-zueoyesj	1245	94	mechanotransduction	mechanotransduction	NN
cord-000248-zueoyesj	1245	95	Decreased	decrease	VBD
cord-000248-zueoyesj	1245	96	mechanical	mechanical	JJ
cord-000248-zueoyesj	1245	97	stiffness	stiffness	NN
cord-000248-zueoyesj	1245	98	in	in	IN
cord-000248-zueoyesj	1245	99	LMNA2/2	LMNA2/2	NNP
cord-000248-zueoyesj	1245	100	cells	cell	NNS
cord-000248-zueoyesj	1245	101	is	be	VBZ
cord-000248-zueoyesj	1245	102	caused	cause	VBN
cord-000248-zueoyesj	1245	103	by	by	IN
cord-000248-zueoyesj	1245	104	defective	defective	JJ
cord-000248-zueoyesj	1245	105	nucleo	nucleo	JJ
cord-000248-zueoyesj	1245	106	-	-	JJ
cord-000248-zueoyesj	1245	107	cytoskeletal	cytoskeletal	JJ
cord-000248-zueoyesj	1245	108	integrity	integrity	NN
cord-000248-zueoyesj	1245	109	:	:	:
cord-000248-zueoyesj	1246	1	implications	implication	NNS
cord-000248-zueoyesj	1246	2	for	for	IN
cord-000248-zueoyesj	1246	3	the	the	DT
cord-000248-zueoyesj	1246	4	development	development	NN
cord-000248-zueoyesj	1246	5	of	of	IN
cord-000248-zueoyesj	1246	6	laminopathies	laminopathies	NNP
cord-000248-zueoyesj	1246	7	Stabilization	Stabilization	NNP
cord-000248-zueoyesj	1246	8	of	of	IN
cord-000248-zueoyesj	1246	9	the	the	DT
cord-000248-zueoyesj	1246	10	retinoblastoma	retinoblastoma	NN
cord-000248-zueoyesj	1246	11	protein	protein	NN
cord-000248-zueoyesj	1246	12	by	by	IN
cord-000248-zueoyesj	1246	13	A	a	DT
cord-000248-zueoyesj	1246	14	-	-	HYPH
cord-000248-zueoyesj	1246	15	type	type	NN
cord-000248-zueoyesj	1246	16	nuclear	nuclear	JJ
cord-000248-zueoyesj	1246	17	lamins	lamin	NNS
cord-000248-zueoyesj	1246	18	is	be	VBZ
cord-000248-zueoyesj	1246	19	required	require	VBN
cord-000248-zueoyesj	1246	20	for	for	IN
cord-000248-zueoyesj	1246	21	INK4A	INK4A	NNS
cord-000248-zueoyesj	1246	22	-	-	HYPH
cord-000248-zueoyesj	1246	23	mediated	mediate	VBN
cord-000248-zueoyesj	1246	24	cell	cell	NN
cord-000248-zueoyesj	1246	25	cycle	cycle	NN
cord-000248-zueoyesj	1246	26	arrest	arrest	NN
cord-000248-zueoyesj	1247	1	A	a	DT
cord-000248-zueoyesj	1247	2	-	-	HYPH
cord-000248-zueoyesj	1247	3	type	type	NN
cord-000248-zueoyesj	1247	4	lamins	lamin	NNS
cord-000248-zueoyesj	1247	5	regulate	regulate	VBP
cord-000248-zueoyesj	1247	6	retinoblastoma	retinoblastoma	NN
cord-000248-zueoyesj	1247	7	protein	protein	NN
cord-000248-zueoyesj	1247	8	function	function	NN
cord-000248-zueoyesj	1247	9	by	by	IN
cord-000248-zueoyesj	1247	10	promoting	promote	VBG
cord-000248-zueoyesj	1247	11	subnuclear	subnuclear	JJ
cord-000248-zueoyesj	1247	12	localization	localization	NN
cord-000248-zueoyesj	1247	13	and	and	CC
cord-000248-zueoyesj	1247	14	preventing	prevent	VBG
cord-000248-zueoyesj	1247	15	proteasomal	proteasomal	JJ
cord-000248-zueoyesj	1247	16	degradation	degradation	NN
cord-000248-zueoyesj	1248	1	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1248	2	lamin	lamin	NN
cord-000248-zueoyesj	1248	3	A	A	NNP
cord-000248-zueoyesj	1248	4	inhibits	inhibit	VBZ
cord-000248-zueoyesj	1248	5	adipocyte	adipocyte	NN
cord-000248-zueoyesj	1248	6	differentiation	differentiation	NN
cord-000248-zueoyesj	1248	7	:	:	:
cord-000248-zueoyesj	1249	1	implications	implication	NNS
cord-000248-zueoyesj	1249	2	for	for	IN
cord-000248-zueoyesj	1249	3	Dunnigan	Dunnigan	NNP
cord-000248-zueoyesj	1249	4	-	-	HYPH
cord-000248-zueoyesj	1249	5	type	type	NN
cord-000248-zueoyesj	1249	6	familial	familial	JJ
cord-000248-zueoyesj	1249	7	partial	partial	JJ
cord-000248-zueoyesj	1249	8	lipodystrophy	lipodystrophy	NN
cord-000248-zueoyesj	1249	9	A	a	NN
cord-000248-zueoyesj	1249	10	-	-	HYPH
cord-000248-zueoyesj	1249	11	type	type	NN
cord-000248-zueoyesj	1249	12	lamins	lamin	NNS
cord-000248-zueoyesj	1249	13	:	:	:
cord-000248-zueoyesj	1249	14	guardians	guardian	NNS
cord-000248-zueoyesj	1249	15	of	of	IN
cord-000248-zueoyesj	1249	16	the	the	DT
cord-000248-zueoyesj	1249	17	soma	soma	NNP
cord-000248-zueoyesj	1249	18	?	?	.
cord-000248-zueoyesj	1250	1	Downregulation	Downregulation	NNP
cord-000248-zueoyesj	1250	2	of	of	IN
cord-000248-zueoyesj	1250	3	human	human	JJ
cord-000248-zueoyesj	1250	4	X	x	NN
cord-000248-zueoyesj	1250	5	-	-	HYPH
cord-000248-zueoyesj	1250	6	box	box	NN
cord-000248-zueoyesj	1250	7	binding	bind	VBG
cord-000248-zueoyesj	1250	8	protein	protein	NN
cord-000248-zueoyesj	1250	9	1	1	CD
cord-000248-zueoyesj	1250	10	(	(	-LRB-
cord-000248-zueoyesj	1250	11	hXBP-1	hxbp-1	CD
cord-000248-zueoyesj	1250	12	)	)	-RRB-
cord-000248-zueoyesj	1250	13	expression	expression	NN
cord-000248-zueoyesj	1250	14	correlates	correlate	VBZ
cord-000248-zueoyesj	1250	15	with	with	IN
cord-000248-zueoyesj	1250	16	tumor	tumor	NN
cord-000248-zueoyesj	1250	17	progression	progression	NN
cord-000248-zueoyesj	1250	18	in	in	IN
cord-000248-zueoyesj	1250	19	human	human	JJ
cord-000248-zueoyesj	1250	20	prostate	prostate	NN
cord-000248-zueoyesj	1250	21	cancers	cancer	NNS
cord-000248-zueoyesj	1251	1	The	the	DT
cord-000248-zueoyesj	1251	2	proapoptotic	proapoptotic	JJ
cord-000248-zueoyesj	1251	3	kinase	kinase	VBZ
cord-000248-zueoyesj	1251	4	Mst1	Mst1	NNP
cord-000248-zueoyesj	1251	5	and	and	CC
cord-000248-zueoyesj	1251	6	its	-PRON-	PRP$
cord-000248-zueoyesj	1251	7	caspase	caspase	NN
cord-000248-zueoyesj	1251	8	cleavage	cleavage	NN
cord-000248-zueoyesj	1251	9	products	product	NNS
cord-000248-zueoyesj	1251	10	are	be	VBP
cord-000248-zueoyesj	1251	11	direct	direct	JJ
cord-000248-zueoyesj	1251	12	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	1251	13	of	of	IN
cord-000248-zueoyesj	1251	14	Akt1	Akt1	NNP
cord-000248-zueoyesj	1251	15	Gene	Gene	NNP
cord-000248-zueoyesj	1251	16	network	network	NN
cord-000248-zueoyesj	1251	17	and	and	CC
cord-000248-zueoyesj	1251	18	canonical	canonical	JJ
cord-000248-zueoyesj	1251	19	pathway	pathway	NN
cord-000248-zueoyesj	1251	20	analysis	analysis	NN
cord-000248-zueoyesj	1251	21	in	in	IN
cord-000248-zueoyesj	1251	22	prostate	prostate	NN
cord-000248-zueoyesj	1251	23	cancer	cancer	NN
cord-000248-zueoyesj	1251	24	:	:	:
cord-000248-zueoyesj	1251	25	a	a	DT
cord-000248-zueoyesj	1251	26	microarray	microarray	NN
cord-000248-zueoyesj	1251	27	study	study	NN
cord-000248-zueoyesj	1251	28	Biomarker	Biomarker	NNP
cord-000248-zueoyesj	1251	29	expression	expression	NN
cord-000248-zueoyesj	1251	30	patterns	pattern	NNS
cord-000248-zueoyesj	1251	31	that	that	WDT
cord-000248-zueoyesj	1251	32	correlate	correlate	VBP
cord-000248-zueoyesj	1251	33	with	with	IN
cord-000248-zueoyesj	1251	34	high	high	JJ
cord-000248-zueoyesj	1251	35	grade	grade	NN
cord-000248-zueoyesj	1251	36	features	feature	NNS
cord-000248-zueoyesj	1251	37	in	in	IN
cord-000248-zueoyesj	1251	38	treatment	treatment	NN
cord-000248-zueoyesj	1251	39	naive	naive	JJ
cord-000248-zueoyesj	1251	40	,	,	,
cord-000248-zueoyesj	1251	41	organ	organ	NN
cord-000248-zueoyesj	1251	42	-	-	HYPH
cord-000248-zueoyesj	1251	43	confined	confine	VBN
cord-000248-zueoyesj	1251	44	prostate	prostate	NN
cord-000248-zueoyesj	1251	45	cancer	cancer	NN
cord-000248-zueoyesj	1251	46	NF	nf	NN
cord-000248-zueoyesj	1251	47	-	-	HYPH
cord-000248-zueoyesj	1251	48	kappaB2	kappab2	NN
cord-000248-zueoyesj	1251	49	processing	processing	NN
cord-000248-zueoyesj	1251	50	and	and	CC
cord-000248-zueoyesj	1251	51	p52	p52	NN
cord-000248-zueoyesj	1251	52	nuclear	nuclear	JJ
cord-000248-zueoyesj	1251	53	accumulation	accumulation	NN
cord-000248-zueoyesj	1251	54	after	after	IN
cord-000248-zueoyesj	1251	55	androgenic	androgenic	JJ
cord-000248-zueoyesj	1251	56	stimulation	stimulation	NN
cord-000248-zueoyesj	1251	57	of	of	IN
cord-000248-zueoyesj	1251	58	LNCaP	lncap	NN
cord-000248-zueoyesj	1251	59	prostate	prostate	NN
cord-000248-zueoyesj	1251	60	cancer	cancer	NN
cord-000248-zueoyesj	1251	61	cells	cell	NNS
cord-000248-zueoyesj	1252	1	Diverse	diverse	JJ
cord-000248-zueoyesj	1252	2	effects	effect	NNS
cord-000248-zueoyesj	1252	3	of	of	IN
cord-000248-zueoyesj	1252	4	zinc	zinc	NN
cord-000248-zueoyesj	1252	5	on	on	IN
cord-000248-zueoyesj	1252	6	NF	NF	NNP
cord-000248-zueoyesj	1252	7	-	-	HYPH
cord-000248-zueoyesj	1252	8	kappaB	kappaB	NNP
cord-000248-zueoyesj	1252	9	and	and	CC
cord-000248-zueoyesj	1252	10	AP-1	AP-1	NNP
cord-000248-zueoyesj	1252	11	transcription	transcription	NN
cord-000248-zueoyesj	1252	12	factors	factor	NNS
cord-000248-zueoyesj	1252	13	:	:	:
cord-000248-zueoyesj	1252	14	implications	implication	NNS
cord-000248-zueoyesj	1252	15	for	for	IN
cord-000248-zueoyesj	1252	16	prostate	prostate	NN
cord-000248-zueoyesj	1252	17	cancer	cancer	NN
cord-000248-zueoyesj	1252	18	progression	progression	NN
cord-000248-zueoyesj	1252	19	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1252	20	factor	factor	NN
cord-000248-zueoyesj	1253	1	-kappaB	-kappaB	NNP
cord-000248-zueoyesj	1253	2	nuclear	nuclear	JJ
cord-000248-zueoyesj	1253	3	localization	localization	NN
cord-000248-zueoyesj	1253	4	is	be	VBZ
cord-000248-zueoyesj	1253	5	predictive	predictive	JJ
cord-000248-zueoyesj	1253	6	of	of	IN
cord-000248-zueoyesj	1253	7	biochemical	biochemical	JJ
cord-000248-zueoyesj	1253	8	recurrence	recurrence	NN
cord-000248-zueoyesj	1253	9	in	in	IN
cord-000248-zueoyesj	1253	10	patients	patient	NNS
cord-000248-zueoyesj	1253	11	with	with	IN
cord-000248-zueoyesj	1253	12	positive	positive	JJ
cord-000248-zueoyesj	1253	13	margin	margin	NN
cord-000248-zueoyesj	1253	14	prostate	prostate	NN
cord-000248-zueoyesj	1253	15	cancer	cancer	NN
cord-000248-zueoyesj	1253	16	Id-1	Id-1	NNP
cord-000248-zueoyesj	1253	17	expression	expression	NN
cord-000248-zueoyesj	1253	18	promotes	promote	VBZ
cord-000248-zueoyesj	1253	19	cell	cell	NN
cord-000248-zueoyesj	1253	20	survival	survival	NN
cord-000248-zueoyesj	1253	21	through	through	IN
cord-000248-zueoyesj	1253	22	activation	activation	NN
cord-000248-zueoyesj	1253	23	of	of	IN
cord-000248-zueoyesj	1253	24	NF	NF	NNP
cord-000248-zueoyesj	1253	25	-	-	HYPH
cord-000248-zueoyesj	1253	26	kappaB	kappaB	NNP
cord-000248-zueoyesj	1253	27	signalling	signal	VBG
cord-000248-zueoyesj	1253	28	pathway	pathway	NN
cord-000248-zueoyesj	1253	29	in	in	IN
cord-000248-zueoyesj	1253	30	prostate	prostate	NN
cord-000248-zueoyesj	1253	31	cancer	cancer	NN
cord-000248-zueoyesj	1253	32	cells	cell	NNS
cord-000248-zueoyesj	1253	33	Suppression	suppression	NN
cord-000248-zueoyesj	1253	34	of	of	IN
cord-000248-zueoyesj	1253	35	hormone	hormone	NN
cord-000248-zueoyesj	1253	36	-	-	HYPH
cord-000248-zueoyesj	1253	37	refractory	refractory	JJ
cord-000248-zueoyesj	1253	38	prostate	prostate	NN
cord-000248-zueoyesj	1253	39	cancer	cancer	NN
cord-000248-zueoyesj	1253	40	by	by	IN
cord-000248-zueoyesj	1253	41	a	a	DT
cord-000248-zueoyesj	1253	42	novel	novel	JJ
cord-000248-zueoyesj	1253	43	nuclear	nuclear	JJ
cord-000248-zueoyesj	1253	44	factor	factor	NN
cord-000248-zueoyesj	1253	45	kappaB	kappaB	NNP
cord-000248-zueoyesj	1253	46	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1253	47	in	in	IN
cord-000248-zueoyesj	1253	48	nude	nude	JJ
cord-000248-zueoyesj	1253	49	mice	mouse	NNS
cord-000248-zueoyesj	1253	50	Mechanisms	Mechanisms	NNPS
cord-000248-zueoyesj	1253	51	of	of	IN
cord-000248-zueoyesj	1253	52	constitutive	constitutive	JJ
cord-000248-zueoyesj	1253	53	NF	nf	NN
cord-000248-zueoyesj	1253	54	-	-	HYPH
cord-000248-zueoyesj	1253	55	kappaB	kappaB	NNP
cord-000248-zueoyesj	1253	56	activation	activation	NN
cord-000248-zueoyesj	1253	57	in	in	IN
cord-000248-zueoyesj	1253	58	human	human	JJ
cord-000248-zueoyesj	1253	59	prostate	prostate	NN
cord-000248-zueoyesj	1253	60	cancer	cancer	NN
cord-000248-zueoyesj	1253	61	cells	cell	NNS
cord-000248-zueoyesj	1254	1	Bcl-2	Bcl-2	NNP
cord-000248-zueoyesj	1254	2	suppresses	suppress	VBZ
cord-000248-zueoyesj	1254	3	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1254	4	resulting	result	VBG
cord-000248-zueoyesj	1254	5	from	from	IN
cord-000248-zueoyesj	1254	6	disruption	disruption	NN
cord-000248-zueoyesj	1254	7	of	of	IN
cord-000248-zueoyesj	1254	8	the	the	DT
cord-000248-zueoyesj	1254	9	NF	nf	NN
cord-000248-zueoyesj	1254	10	-	-	HYPH
cord-000248-zueoyesj	1254	11	kappa	kappa	NNP
cord-000248-zueoyesj	1254	12	B	B	NNP
cord-000248-zueoyesj	1254	13	survival	survival	NN
cord-000248-zueoyesj	1254	14	pathway	pathway	NN
cord-000248-zueoyesj	1254	15	Gene	Gene	NNP
cord-000248-zueoyesj	1254	16	expression	expression	NN
cord-000248-zueoyesj	1254	17	profiling	profiling	NN
cord-000248-zueoyesj	1254	18	of	of	IN
cord-000248-zueoyesj	1254	19	human	human	JJ
cord-000248-zueoyesj	1254	20	prostate	prostate	NN
cord-000248-zueoyesj	1254	21	cancer	cancer	NN
cord-000248-zueoyesj	1254	22	stem	stem	NN
cord-000248-zueoyesj	1254	23	cells	cell	NNS
cord-000248-zueoyesj	1255	1	reveals	reveal	VBZ
cord-000248-zueoyesj	1255	2	a	a	DT
cord-000248-zueoyesj	1255	3	proinflammatory	proinflammatory	JJ
cord-000248-zueoyesj	1255	4	phenotype	phenotype	NN
cord-000248-zueoyesj	1255	5	and	and	CC
cord-000248-zueoyesj	1255	6	the	the	DT
cord-000248-zueoyesj	1255	7	importance	importance	NN
cord-000248-zueoyesj	1255	8	of	of	IN
cord-000248-zueoyesj	1255	9	extracellular	extracellular	JJ
cord-000248-zueoyesj	1255	10	matrix	matrix	NN
cord-000248-zueoyesj	1255	11	interactions	interaction	NNS
cord-000248-zueoyesj	1255	12	Molecular	molecular	JJ
cord-000248-zueoyesj	1255	13	imaging	imaging	NN
cord-000248-zueoyesj	1255	14	of	of	IN
cord-000248-zueoyesj	1255	15	NF	NF	NNP
cord-000248-zueoyesj	1255	16	-	-	HYPH
cord-000248-zueoyesj	1255	17	kappaB	kappaB	NNP
cord-000248-zueoyesj	1255	18	in	in	IN
cord-000248-zueoyesj	1255	19	prostate	prostate	NN
cord-000248-zueoyesj	1255	20	tissue	tissue	NN
cord-000248-zueoyesj	1255	21	after	after	IN
cord-000248-zueoyesj	1255	22	systemic	systemic	JJ
cord-000248-zueoyesj	1255	23	administration	administration	NN
cord-000248-zueoyesj	1255	24	of	of	IN
cord-000248-zueoyesj	1255	25	IL-1	IL-1	NNP
cord-000248-zueoyesj	1255	26	beta	beta	NNP
cord-000248-zueoyesj	1255	27	TNF	TNF	NNP
cord-000248-zueoyesj	1255	28	/	/	SYM
cord-000248-zueoyesj	1255	29	IL-1	IL-1	NNP
cord-000248-zueoyesj	1255	30	/	/	SYM
cord-000248-zueoyesj	1255	31	NIK	NIK	NNP
cord-000248-zueoyesj	1255	32	/	/	SYM
cord-000248-zueoyesj	1255	33	NF	NF	NNP
cord-000248-zueoyesj	1255	34	-	-	HYPH
cord-000248-zueoyesj	1255	35	kappa	kappa	NN
cord-000248-zueoyesj	1255	36	B	B	NNP
cord-000248-zueoyesj	1255	37	transduction	transduction	NN
cord-000248-zueoyesj	1255	38	pathway	pathway	NN
cord-000248-zueoyesj	1255	39	:	:	:
cord-000248-zueoyesj	1255	40	a	a	DT
cord-000248-zueoyesj	1255	41	comparative	comparative	JJ
cord-000248-zueoyesj	1255	42	study	study	NN
cord-000248-zueoyesj	1255	43	in	in	IN
cord-000248-zueoyesj	1255	44	normal	normal	JJ
cord-000248-zueoyesj	1255	45	and	and	CC
cord-000248-zueoyesj	1255	46	pathological	pathological	JJ
cord-000248-zueoyesj	1255	47	human	human	JJ
cord-000248-zueoyesj	1255	48	prostate	prostate	NN
cord-000248-zueoyesj	1255	49	(	(	-LRB-
cord-000248-zueoyesj	1255	50	benign	benign	JJ
cord-000248-zueoyesj	1255	51	hyperplasia	hyperplasia	NN
cord-000248-zueoyesj	1255	52	and	and	CC
cord-000248-zueoyesj	1255	53	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1255	54	)	)	-RRB-
cord-000248-zueoyesj	1256	1	Proteasome	Proteasome	NNP
cord-000248-zueoyesj	1256	2	inhibitors	inhibitor	NNS
cord-000248-zueoyesj	1256	3	induce	induce	VBP
cord-000248-zueoyesj	1256	4	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1256	5	of	of	IN
cord-000248-zueoyesj	1256	6	prostate	prostate	NN
cord-000248-zueoyesj	1256	7	cancer	cancer	NN
cord-000248-zueoyesj	1256	8	cells	cell	NNS
cord-000248-zueoyesj	1256	9	by	by	IN
cord-000248-zueoyesj	1256	10	inducing	induce	VBG
cord-000248-zueoyesj	1256	11	nuclear	nuclear	JJ
cord-000248-zueoyesj	1256	12	translocation	translocation	NN
cord-000248-zueoyesj	1256	13	of	of	IN
cord-000248-zueoyesj	1256	14	IkappaBalpha	IkappaBalpha	NNP
cord-000248-zueoyesj	1256	15	Targeting	target	VBG
cord-000248-zueoyesj	1256	16	the	the	DT
cord-000248-zueoyesj	1256	17	receptor	receptor	NN
cord-000248-zueoyesj	1256	18	activator	activator	NN
cord-000248-zueoyesj	1256	19	of	of	IN
cord-000248-zueoyesj	1256	20	nuclear	nuclear	JJ
cord-000248-zueoyesj	1256	21	factor	factor	NN
cord-000248-zueoyesj	1256	22	-	-	:
cord-000248-zueoyesj	1256	23	kappaB	kappaB	NNP
cord-000248-zueoyesj	1256	24	(	(	-LRB-
cord-000248-zueoyesj	1256	25	RANK	rank	NN
cord-000248-zueoyesj	1256	26	)	)	-RRB-
cord-000248-zueoyesj	1256	27	ligand	ligand	NN
cord-000248-zueoyesj	1256	28	in	in	IN
cord-000248-zueoyesj	1256	29	prostate	prostate	NN
cord-000248-zueoyesj	1256	30	cancer	cancer	NN
cord-000248-zueoyesj	1256	31	bone	bone	NN
cord-000248-zueoyesj	1256	32	metastases	metastase	VBZ
cord-000248-zueoyesj	1256	33	Pomegranate	Pomegranate	NNP
cord-000248-zueoyesj	1256	34	extract	extract	NN
cord-000248-zueoyesj	1256	35	inhibits	inhibit	VBZ
cord-000248-zueoyesj	1256	36	androgen	androgen	NN
cord-000248-zueoyesj	1256	37	-	-	HYPH
cord-000248-zueoyesj	1256	38	independent	independent	JJ
cord-000248-zueoyesj	1256	39	prostate	prostate	NN
cord-000248-zueoyesj	1256	40	cancer	cancer	NN
cord-000248-zueoyesj	1256	41	growth	growth	NN
cord-000248-zueoyesj	1256	42	through	through	IN
cord-000248-zueoyesj	1256	43	a	a	DT
cord-000248-zueoyesj	1256	44	nuclear	nuclear	JJ
cord-000248-zueoyesj	1256	45	factor	factor	NN
cord-000248-zueoyesj	1256	46	-	-	HYPH
cord-000248-zueoyesj	1256	47	kappaB	kappaB	NNP
cord-000248-zueoyesj	1256	48	-	-	HYPH
cord-000248-zueoyesj	1256	49	dependent	dependent	JJ
cord-000248-zueoyesj	1256	50	mechanism	mechanism	NN
cord-000248-zueoyesj	1257	1	The	the	DT
cord-000248-zueoyesj	1257	2	nuclear	nuclear	JJ
cord-000248-zueoyesj	1257	3	factor	factor	NN
cord-000248-zueoyesj	1257	4	-	-	:
cord-000248-zueoyesj	1257	5	kappaB	kappaB	NNP
cord-000248-zueoyesj	1257	6	pathway	pathway	NN
cord-000248-zueoyesj	1257	7	controls	control	VBZ
cord-000248-zueoyesj	1257	8	the	the	DT
cord-000248-zueoyesj	1257	9	progression	progression	NN
cord-000248-zueoyesj	1257	10	of	of	IN
cord-000248-zueoyesj	1257	11	prostate	prostate	NN
cord-000248-zueoyesj	1257	12	cancer	cancer	NN
cord-000248-zueoyesj	1257	13	to	to	IN
cord-000248-zueoyesj	1257	14	androgenindependent	androgenindependent	NN
cord-000248-zueoyesj	1257	15	growth	growth	NN
cord-000248-zueoyesj	1258	1	A	a	DT
cord-000248-zueoyesj	1258	2	new	new	JJ
cord-000248-zueoyesj	1258	3	prostate	prostate	NN
cord-000248-zueoyesj	1258	4	cancer	cancer	NN
cord-000248-zueoyesj	1258	5	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1258	6	approach	approach	NN
cord-000248-zueoyesj	1258	7	:	:	:
cord-000248-zueoyesj	1258	8	combination	combination	NN
cord-000248-zueoyesj	1258	9	of	of	IN
cord-000248-zueoyesj	1258	10	androgen	androgen	NN
cord-000248-zueoyesj	1258	11	ablation	ablation	NN
cord-000248-zueoyesj	1258	12	with	with	IN
cord-000248-zueoyesj	1258	13	COX-2	cox-2	JJ
cord-000248-zueoyesj	1258	14	inhibitor	inhibitor	NN
cord-000248-zueoyesj	1258	15	Inhibitory	inhibitory	JJ
cord-000248-zueoyesj	1258	16	effect	effect	NN
cord-000248-zueoyesj	1258	17	of	of	IN
cord-000248-zueoyesj	1258	18	snake	snake	NN
cord-000248-zueoyesj	1258	19	venom	venom	NN
cord-000248-zueoyesj	1258	20	toxin	toxin	NN
cord-000248-zueoyesj	1258	21	from	from	IN
cord-000248-zueoyesj	1258	22	Vipera	Vipera	NNP
cord-000248-zueoyesj	1258	23	lebetina	lebetina	NNP
cord-000248-zueoyesj	1258	24	turanica	turanica	NNP
cord-000248-zueoyesj	1258	25	on	on	IN
cord-000248-zueoyesj	1258	26	hormone	hormone	NN
cord-000248-zueoyesj	1258	27	-	-	HYPH
cord-000248-zueoyesj	1258	28	refractory	refractory	JJ
cord-000248-zueoyesj	1258	29	human	human	JJ
cord-000248-zueoyesj	1258	30	prostate	prostate	NN
cord-000248-zueoyesj	1258	31	cancer	cancer	NN
cord-000248-zueoyesj	1258	32	cell	cell	NN
cord-000248-zueoyesj	1258	33	growth	growth	NN
cord-000248-zueoyesj	1258	34	:	:	:
cord-000248-zueoyesj	1258	35	induction	induction	NN
cord-000248-zueoyesj	1258	36	of	of	IN
cord-000248-zueoyesj	1258	37	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1258	38	through	through	IN
cord-000248-zueoyesj	1258	39	inactivation	inactivation	NN
cord-000248-zueoyesj	1258	40	of	of	IN
cord-000248-zueoyesj	1258	41	nuclear	nuclear	JJ
cord-000248-zueoyesj	1258	42	factor	factor	NN
cord-000248-zueoyesj	1258	43	kappaB	kappaB	NNP
cord-000248-zueoyesj	1258	44	Prostate	Prostate	NNP
cord-000248-zueoyesj	1258	45	cancer	cancer	NN
cord-000248-zueoyesj	1258	46	chemoprevention	chemoprevention	NN
cord-000248-zueoyesj	1258	47	by	by	IN
cord-000248-zueoyesj	1258	48	silibinin	silibinin	NNP
cord-000248-zueoyesj	1258	49	:	:	:
cord-000248-zueoyesj	1259	1	bench	bench	NN
cord-000248-zueoyesj	1259	2	to	to	IN
cord-000248-zueoyesj	1259	3	bedside	bedside	NN
cord-000248-zueoyesj	1259	4	Genistein	Genistein	NNP
cord-000248-zueoyesj	1259	5	inhibits	inhibit	VBZ
cord-000248-zueoyesj	1259	6	radiation	radiation	NN
cord-000248-zueoyesj	1259	7	-	-	HYPH
cord-000248-zueoyesj	1259	8	induced	induce	VBN
cord-000248-zueoyesj	1259	9	activation	activation	NN
cord-000248-zueoyesj	1259	10	of	of	IN
cord-000248-zueoyesj	1259	11	NF	NF	NNP
cord-000248-zueoyesj	1259	12	-	-	HYPH
cord-000248-zueoyesj	1259	13	kappaB	kappaB	NNP
cord-000248-zueoyesj	1259	14	in	in	IN
cord-000248-zueoyesj	1259	15	prostate	prostate	NN
cord-000248-zueoyesj	1259	16	cancer	cancer	NN
cord-000248-zueoyesj	1259	17	cells	cell	NNS
cord-000248-zueoyesj	1259	18	promoting	promote	VBG
cord-000248-zueoyesj	1259	19	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1259	20	and	and	CC
cord-000248-zueoyesj	1259	21	G2	G2	NNP
cord-000248-zueoyesj	1259	22	/	/	SYM
cord-000248-zueoyesj	1259	23	M	M	NNP
cord-000248-zueoyesj	1259	24	cell	cell	NN
cord-000248-zueoyesj	1259	25	cycle	cycle	NN
cord-000248-zueoyesj	1259	26	arrest	arrest	NN
cord-000248-zueoyesj	1260	1	NF	NF	NNP
cord-000248-zueoyesj	1260	2	-	-	HYPH
cord-000248-zueoyesj	1260	3	kappaB	kappaB	NNP
cord-000248-zueoyesj	1260	4	inhibition	inhibition	NN
cord-000248-zueoyesj	1260	5	increases	increase	VBZ
cord-000248-zueoyesj	1260	6	chemosensitivity	chemosensitivity	NN
cord-000248-zueoyesj	1260	7	to	to	IN
cord-000248-zueoyesj	1260	8	trichostatin	trichostatin	NNP
cord-000248-zueoyesj	1260	9	A	a	DT
cord-000248-zueoyesj	1260	10	-	-	HYPH
cord-000248-zueoyesj	1260	11	induced	induce	VBN
cord-000248-zueoyesj	1260	12	cell	cell	NN
cord-000248-zueoyesj	1260	13	death	death	NN
cord-000248-zueoyesj	1260	14	of	of	IN
cord-000248-zueoyesj	1260	15	Ki	Ki	NNP
cord-000248-zueoyesj	1260	16	-	-	HYPH
cord-000248-zueoyesj	1260	17	Ras	Ras	NNP
cord-000248-zueoyesj	1260	18	-	-	HYPH
cord-000248-zueoyesj	1260	19	transformed	transform	VBN
cord-000248-zueoyesj	1260	20	human	human	JJ
cord-000248-zueoyesj	1260	21	prostate	prostate	NN
cord-000248-zueoyesj	1260	22	epithelial	epithelial	NN
cord-000248-zueoyesj	1260	23	cells	cell	NNS
cord-000248-zueoyesj	1260	24	Involvement	Involvement	NNP
cord-000248-zueoyesj	1260	25	of	of	IN
cord-000248-zueoyesj	1260	26	the	the	DT
cord-000248-zueoyesj	1260	27	TNF	TNF	NNP
cord-000248-zueoyesj	1260	28	-	-	HYPH
cord-000248-zueoyesj	1260	29	alpha	alpha	NN
cord-000248-zueoyesj	1260	30	autocrine	autocrine	NN
cord-000248-zueoyesj	1260	31	-	-	HYPH
cord-000248-zueoyesj	1260	32	paracrine	paracrine	NN
cord-000248-zueoyesj	1260	33	loop	loop	NN
cord-000248-zueoyesj	1260	34	,	,	,
cord-000248-zueoyesj	1260	35	via	via	IN
cord-000248-zueoyesj	1260	36	NF	NF	NNP
cord-000248-zueoyesj	1260	37	-	-	HYPH
cord-000248-zueoyesj	1260	38	kappaB	kappaB	NNP
cord-000248-zueoyesj	1260	39	and	and	CC
cord-000248-zueoyesj	1260	40	YY1	YY1	NNP
cord-000248-zueoyesj	1260	41	,	,	,
cord-000248-zueoyesj	1260	42	in	in	IN
cord-000248-zueoyesj	1260	43	the	the	DT
cord-000248-zueoyesj	1260	44	regulation	regulation	NN
cord-000248-zueoyesj	1260	45	of	of	IN
cord-000248-zueoyesj	1260	46	tumor	tumor	NN
cord-000248-zueoyesj	1260	47	cell	cell	NN
cord-000248-zueoyesj	1260	48	resistance	resistance	NN
cord-000248-zueoyesj	1260	49	to	to	IN
cord-000248-zueoyesj	1261	1	Fas	Fas	NNP
cord-000248-zueoyesj	1261	2	-	-	HYPH
cord-000248-zueoyesj	1261	3	induced	induce	VBN
cord-000248-zueoyesj	1261	4	apoptosis	apoptosis	NN
cord-000248-zueoyesj	1261	5	Estrogens	estrogen	NNS
cord-000248-zueoyesj	1261	6	and	and	CC
cord-000248-zueoyesj	1261	7	antiestrogens	antiestrogen	VBZ
cord-000248-zueoyesj	1261	8	as	as	IN
cord-000248-zueoyesj	1261	9	etiological	etiological	JJ
cord-000248-zueoyesj	1261	10	factors	factor	NNS
cord-000248-zueoyesj	1261	11	and	and	CC
cord-000248-zueoyesj	1261	12	therapeutics	therapeutic	NNS
cord-000248-zueoyesj	1261	13	for	for	IN
cord-000248-zueoyesj	1261	14	prostate	prostate	NN
cord-000248-zueoyesj	1261	15	cancer	cancer	NN
cord-000248-zueoyesj	1261	16	NF	nf	NN
cord-000248-zueoyesj	1261	17	-	-	HYPH
cord-000248-zueoyesj	1261	18	kappaB	kappaB	NNP
cord-000248-zueoyesj	1261	19	activation	activation	NN
cord-000248-zueoyesj	1262	1	upregulates	upregulate	VBZ
cord-000248-zueoyesj	1262	2	fibroblast	fibroblast	NN
cord-000248-zueoyesj	1262	3	growth	growth	NN
cord-000248-zueoyesj	1262	4	factor	factor	NN
cord-000248-zueoyesj	1262	5	8	8	CD
cord-000248-zueoyesj	1262	6	expression	expression	NN
cord-000248-zueoyesj	1262	7	in	in	IN
cord-000248-zueoyesj	1262	8	prostate	prostate	NN
cord-000248-zueoyesj	1262	9	cancer	cancer	NN
cord-000248-zueoyesj	1262	10	cells	cell	NNS
cord-000248-zueoyesj	1263	1	Anticancer	anticancer	JJ
cord-000248-zueoyesj	1263	2	potential	potential	NN
cord-000248-zueoyesj	1263	3	of	of	IN
cord-000248-zueoyesj	1263	4	silymarin	silymarin	NNP
cord-000248-zueoyesj	1264	1	:	:	:
cord-000248-zueoyesj	1264	2	from	from	IN
cord-000248-zueoyesj	1264	3	bench	bench	NN
cord-000248-zueoyesj	1264	4	to	to	IN
cord-000248-zueoyesj	1264	5	bed	bed	NN
cord-000248-zueoyesj	1264	6	side	side	NN
cord-000248-zueoyesj	1264	7	Blockage	blockage	NN
cord-000248-zueoyesj	1264	8	of	of	IN
cord-000248-zueoyesj	1264	9	NF	NF	NNP
cord-000248-zueoyesj	1264	10	-	-	HYPH
cord-000248-zueoyesj	1264	11	kappaB	kappaB	NNP
cord-000248-zueoyesj	1264	12	induces	induce	VBZ
cord-000248-zueoyesj	1264	13	serine	serine	NN
cord-000248-zueoyesj	1264	14	15	15	CD
cord-000248-zueoyesj	1264	15	phosphorylation	phosphorylation	NN
cord-000248-zueoyesj	1264	16	of	of	IN
cord-000248-zueoyesj	1264	17	mutant	mutant	JJ
cord-000248-zueoyesj	1264	18	p53	p53	NN
cord-000248-zueoyesj	1264	19	by	by	IN
cord-000248-zueoyesj	1264	20	JNK	JNK	NNP
cord-000248-zueoyesj	1264	21	kinase	kinase	NN
cord-000248-zueoyesj	1264	22	in	in	IN
cord-000248-zueoyesj	1264	23	prostate	prostate	NN
cord-000248-zueoyesj	1264	24	cancer	cancer	NN
cord-000248-zueoyesj	1264	25	cells	cell	NNS
cord-000248-zueoyesj	1265	1	Skp2	skp2	NN
cord-000248-zueoyesj	1265	2	enhances	enhance	VBZ
cord-000248-zueoyesj	1265	3	polyubiquitination	polyubiquitination	NN
cord-000248-zueoyesj	1265	4	and	and	CC
cord-000248-zueoyesj	1265	5	degradation	degradation	NN
cord-000248-zueoyesj	1265	6	of	of	IN
cord-000248-zueoyesj	1265	7	TIS21	TIS21	NNPS
cord-000248-zueoyesj	1265	8	/	/	SYM
cord-000248-zueoyesj	1265	9	BTG2	BTG2	NNP
cord-000248-zueoyesj	1265	10	/	/	SYM
cord-000248-zueoyesj	1265	11	PC3	PC3	NNP
cord-000248-zueoyesj	1265	12	,	,	,
cord-000248-zueoyesj	1265	13	tumor	tumor	NN
cord-000248-zueoyesj	1265	14	suppressor	suppressor	NN
cord-000248-zueoyesj	1265	15	protein	protein	NN
cord-000248-zueoyesj	1265	16	,	,	,
cord-000248-zueoyesj	1265	17	at	at	IN
cord-000248-zueoyesj	1265	18	the	the	DT
cord-000248-zueoyesj	1265	19	downstream	downstream	NN
cord-000248-zueoyesj	1265	20	of	of	IN
cord-000248-zueoyesj	1265	21	FoxM1	FoxM1	NNP
cord-000248-zueoyesj	1265	22	Triiodothyronine	Triiodothyronine	NNP
cord-000248-zueoyesj	1266	1	modulates	modulate	VBZ
cord-000248-zueoyesj	1266	2	cell	cell	NN
cord-000248-zueoyesj	1266	3	proliferation	proliferation	NN
cord-000248-zueoyesj	1266	4	of	of	IN
cord-000248-zueoyesj	1266	5	human	human	JJ
cord-000248-zueoyesj	1266	6	prostatic	prostatic	JJ
cord-000248-zueoyesj	1266	7	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1266	8	cells	cell	NNS
cord-000248-zueoyesj	1266	9	by	by	IN
cord-000248-zueoyesj	1266	10	downregulation	downregulation	NN
cord-000248-zueoyesj	1266	11	of	of	IN
cord-000248-zueoyesj	1266	12	the	the	DT
cord-000248-zueoyesj	1266	13	B	b	NN
cord-000248-zueoyesj	1266	14	-	-	HYPH
cord-000248-zueoyesj	1266	15	cell	cell	NN
cord-000248-zueoyesj	1266	16	translocation	translocation	NN
cord-000248-zueoyesj	1266	17	gene	gene	NN
cord-000248-zueoyesj	1266	18	2	2	CD
cord-000248-zueoyesj	1266	19	B	b	NN
cord-000248-zueoyesj	1266	20	cell	cell	NN
cord-000248-zueoyesj	1266	21	translocation	translocation	NN
cord-000248-zueoyesj	1266	22	gene	gene	NN
cord-000248-zueoyesj	1266	23	2	2	CD
cord-000248-zueoyesj	1266	24	enhances	enhance	VBZ
cord-000248-zueoyesj	1266	25	susceptibility	susceptibility	NN
cord-000248-zueoyesj	1266	26	of	of	IN
cord-000248-zueoyesj	1266	27	HeLa	HeLa	NNP
cord-000248-zueoyesj	1266	28	cells	cell	NNS
cord-000248-zueoyesj	1266	29	to	to	IN
cord-000248-zueoyesj	1266	30	doxorubicin	doxorubicin	NN
cord-000248-zueoyesj	1266	31	-	-	HYPH
cord-000248-zueoyesj	1266	32	induced	induce	VBN
cord-000248-zueoyesj	1266	33	oxidative	oxidative	JJ
cord-000248-zueoyesj	1266	34	damage	damage	NN
cord-000248-zueoyesj	1266	35	TIS21	TIS21	NNS
cord-000248-zueoyesj	1267	1	(	(	-LRB-
cord-000248-zueoyesj	1267	2	/BTG2	/BTG2	NNP
cord-000248-zueoyesj	1267	3	/	/	SYM
cord-000248-zueoyesj	1267	4	PC3	PC3	NNP
cord-000248-zueoyesj	1267	5	)	)	-RRB-
cord-000248-zueoyesj	1268	1	as	as	IN
cord-000248-zueoyesj	1268	2	a	a	DT
cord-000248-zueoyesj	1268	3	link	link	NN
cord-000248-zueoyesj	1268	4	between	between	IN
cord-000248-zueoyesj	1268	5	ageing	age	VBG
cord-000248-zueoyesj	1268	6	and	and	CC
cord-000248-zueoyesj	1268	7	cancer	cancer	NN
cord-000248-zueoyesj	1268	8	:	:	:
cord-000248-zueoyesj	1268	9	cell	cell	NN
cord-000248-zueoyesj	1268	10	cycle	cycle	NN
cord-000248-zueoyesj	1268	11	regulator	regulator	NN
cord-000248-zueoyesj	1268	12	and	and	CC
cord-000248-zueoyesj	1268	13	endogenous	endogenous	JJ
cord-000248-zueoyesj	1268	14	cell	cell	NN
cord-000248-zueoyesj	1268	15	death	death	NN
cord-000248-zueoyesj	1268	16	molecule	molecule	NN
cord-000248-zueoyesj	1268	17	Expression	expression	NN
cord-000248-zueoyesj	1268	18	of	of	IN
cord-000248-zueoyesj	1268	19	B	b	NN
cord-000248-zueoyesj	1268	20	-	-	HYPH
cord-000248-zueoyesj	1268	21	cell	cell	NN
cord-000248-zueoyesj	1268	22	translocation	translocation	NN
cord-000248-zueoyesj	1268	23	gene	gene	NN
cord-000248-zueoyesj	1268	24	2	2	CD
cord-000248-zueoyesj	1268	25	protein	protein	NN
cord-000248-zueoyesj	1268	26	in	in	IN
cord-000248-zueoyesj	1268	27	normal	normal	JJ
cord-000248-zueoyesj	1268	28	human	human	JJ
cord-000248-zueoyesj	1268	29	tissues	tissue	NNS
cord-000248-zueoyesj	1268	30	Antiproliferative	Antiproliferative	NNP
cord-000248-zueoyesj	1268	31	B	B	NNP
cord-000248-zueoyesj	1268	32	cell	cell	NN
cord-000248-zueoyesj	1268	33	translocation	translocation	NN
cord-000248-zueoyesj	1268	34	gene	gene	NN
cord-000248-zueoyesj	1268	35	2	2	CD
cord-000248-zueoyesj	1268	36	protein	protein	NN
cord-000248-zueoyesj	1268	37	is	be	VBZ
cord-000248-zueoyesj	1268	38	down	down	RB
cord-000248-zueoyesj	1268	39	-	-	HYPH
cord-000248-zueoyesj	1268	40	regulated	regulate	VBN
cord-000248-zueoyesj	1268	41	posttranscriptionally	posttranscriptionally	RB
cord-000248-zueoyesj	1268	42	as	as	IN
cord-000248-zueoyesj	1268	43	an	an	DT
cord-000248-zueoyesj	1268	44	early	early	JJ
cord-000248-zueoyesj	1268	45	event	event	NN
cord-000248-zueoyesj	1268	46	in	in	IN
cord-000248-zueoyesj	1268	47	prostate	prostate	NN
cord-000248-zueoyesj	1268	48	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1268	49	Identification	identification	NN
cord-000248-zueoyesj	1268	50	of	of	IN
cord-000248-zueoyesj	1268	51	genes	gene	NNS
cord-000248-zueoyesj	1268	52	associated	associate	VBN
cord-000248-zueoyesj	1268	53	with	with	IN
cord-000248-zueoyesj	1268	54	stromal	stromal	JJ
cord-000248-zueoyesj	1268	55	hyperplasia	hyperplasia	NN
cord-000248-zueoyesj	1268	56	and	and	CC
cord-000248-zueoyesj	1268	57	glandular	glandular	JJ
cord-000248-zueoyesj	1268	58	atrophy	atrophy	NN
cord-000248-zueoyesj	1268	59	of	of	IN
cord-000248-zueoyesj	1268	60	the	the	DT
cord-000248-zueoyesj	1268	61	prostate	prostate	NN
cord-000248-zueoyesj	1268	62	by	by	IN
cord-000248-zueoyesj	1268	63	mRNA	mRNA	NNP
cord-000248-zueoyesj	1268	64	differential	differential	JJ
cord-000248-zueoyesj	1268	65	display	display	NN
cord-000248-zueoyesj	1268	66	Role	role	NN
cord-000248-zueoyesj	1268	67	of	of	IN
cord-000248-zueoyesj	1268	68	connective	connective	JJ
cord-000248-zueoyesj	1268	69	tissue	tissue	NN
cord-000248-zueoyesj	1268	70	growth	growth	NN
cord-000248-zueoyesj	1268	71	factor	factor	NN
cord-000248-zueoyesj	1268	72	in	in	IN
cord-000248-zueoyesj	1268	73	fibronectin	fibronectin	NN
cord-000248-zueoyesj	1268	74	synthesis	synthesis	NN
cord-000248-zueoyesj	1268	75	in	in	IN
cord-000248-zueoyesj	1268	76	cultured	cultured	JJ
cord-000248-zueoyesj	1268	77	human	human	JJ
cord-000248-zueoyesj	1268	78	prostate	prostate	NN
cord-000248-zueoyesj	1268	79	stromal	stromal	NN
cord-000248-zueoyesj	1268	80	cells	cell	NNS
cord-000248-zueoyesj	1269	1	Stromal	stromal	JJ
cord-000248-zueoyesj	1269	2	expression	expression	NN
cord-000248-zueoyesj	1269	3	of	of	IN
cord-000248-zueoyesj	1269	4	connective	connective	JJ
cord-000248-zueoyesj	1269	5	tissue	tissue	NN
cord-000248-zueoyesj	1269	6	growth	growth	NN
cord-000248-zueoyesj	1269	7	factor	factor	NN
cord-000248-zueoyesj	1269	8	promotes	promote	VBZ
cord-000248-zueoyesj	1269	9	angiogenesis	angiogenesis	NN
cord-000248-zueoyesj	1269	10	and	and	CC
cord-000248-zueoyesj	1269	11	prostate	prostate	NN
cord-000248-zueoyesj	1269	12	cancer	cancer	NN
cord-000248-zueoyesj	1269	13	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1269	14	Analysis	Analysis	NNP
cord-000248-zueoyesj	1269	15	of	of	IN
cord-000248-zueoyesj	1269	16	gene	gene	NN
cord-000248-zueoyesj	1269	17	expression	expression	NN
cord-000248-zueoyesj	1269	18	during	during	IN
cord-000248-zueoyesj	1269	19	staurosporine	staurosporine	NN
cord-000248-zueoyesj	1269	20	-	-	HYPH
cord-000248-zueoyesj	1269	21	induced	induce	VBN
cord-000248-zueoyesj	1269	22	neuronal	neuronal	JJ
cord-000248-zueoyesj	1269	23	differentiation	differentiation	NN
cord-000248-zueoyesj	1269	24	of	of	IN
cord-000248-zueoyesj	1269	25	human	human	JJ
cord-000248-zueoyesj	1269	26	prostate	prostate	NN
cord-000248-zueoyesj	1269	27	cancer	cancer	NN
cord-000248-zueoyesj	1269	28	cells	cell	NNS
cord-000248-zueoyesj	1269	29	Profiling	profile	VBG
cord-000248-zueoyesj	1269	30	molecular	molecular	JJ
cord-000248-zueoyesj	1269	31	targets	target	NNS
cord-000248-zueoyesj	1269	32	of	of	IN
cord-000248-zueoyesj	1269	33	TGF	TGF	NNP
cord-000248-zueoyesj	1269	34	-	-	HYPH
cord-000248-zueoyesj	1269	35	beta1	beta1	NN
cord-000248-zueoyesj	1269	36	in	in	IN
cord-000248-zueoyesj	1269	37	prostate	prostate	NN
cord-000248-zueoyesj	1269	38	fibroblast	fibroblast	NN
cord-000248-zueoyesj	1269	39	-	-	HYPH
cord-000248-zueoyesj	1269	40	to	to	IN
cord-000248-zueoyesj	1269	41	-	-	HYPH
cord-000248-zueoyesj	1269	42	myofibroblast	myofibroblast	NN
cord-000248-zueoyesj	1269	43	transdifferentiation	transdifferentiation	NN
cord-000248-zueoyesj	1269	44	Expression	expression	NN
cord-000248-zueoyesj	1269	45	of	of	IN
cord-000248-zueoyesj	1269	46	androgen	androgen	NN
cord-000248-zueoyesj	1269	47	receptor	receptor	NN
cord-000248-zueoyesj	1269	48	coregulatory	coregulatory	NNP
cord-000248-zueoyesj	1269	49	proteins	protein	NNS
cord-000248-zueoyesj	1269	50	in	in	IN
cord-000248-zueoyesj	1269	51	prostate	prostate	NN
cord-000248-zueoyesj	1269	52	cancer	cancer	NN
cord-000248-zueoyesj	1269	53	and	and	CC
cord-000248-zueoyesj	1269	54	stromal	stromal	NN
cord-000248-zueoyesj	1269	55	-	-	HYPH
cord-000248-zueoyesj	1269	56	cell	cell	NN
cord-000248-zueoyesj	1269	57	culture	culture	NN
cord-000248-zueoyesj	1269	58	models	model	NNS
cord-000248-zueoyesj	1270	1	FHL2	FHL2	NNP
cord-000248-zueoyesj	1270	2	,	,	,
cord-000248-zueoyesj	1270	3	a	a	DT
cord-000248-zueoyesj	1270	4	novel	novel	JJ
cord-000248-zueoyesj	1270	5	tissue	tissue	NN
cord-000248-zueoyesj	1270	6	-	-	HYPH
cord-000248-zueoyesj	1270	7	specific	specific	JJ
cord-000248-zueoyesj	1270	8	coactivator	coactivator	NN
cord-000248-zueoyesj	1270	9	of	of	IN
cord-000248-zueoyesj	1270	10	the	the	DT
cord-000248-zueoyesj	1270	11	androgen	androgen	NN
cord-000248-zueoyesj	1270	12	receptor	receptor	NN
cord-000248-zueoyesj	1270	13	Four	Four	NNP
cord-000248-zueoyesj	1270	14	and	and	CC
cord-000248-zueoyesj	1270	15	a	a	DT
cord-000248-zueoyesj	1270	16	Half	Half	NNP
cord-000248-zueoyesj	1270	17	LIM	LIM	NNP
cord-000248-zueoyesj	1270	18	Domain	Domain	NNP
cord-000248-zueoyesj	1270	19	2	2	CD
cord-000248-zueoyesj	1270	20	alters	alter	VBZ
cord-000248-zueoyesj	1270	21	the	the	DT
cord-000248-zueoyesj	1270	22	impact	impact	NN
cord-000248-zueoyesj	1270	23	of	of	IN
cord-000248-zueoyesj	1270	24	Aryl	Aryl	NNP
cord-000248-zueoyesj	1270	25	Hydrocarbon	Hydrocarbon	NNP
cord-000248-zueoyesj	1270	26	Receptor	Receptor	NNP
cord-000248-zueoyesj	1270	27	on	on	IN
cord-000248-zueoyesj	1270	28	Androgen	Androgen	NNP
cord-000248-zueoyesj	1270	29	Receptor	Receptor	NNP
cord-000248-zueoyesj	1270	30	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1270	31	activity	activity	NN
cord-000248-zueoyesj	1270	32	Differently	differently	RB
cord-000248-zueoyesj	1270	33	regulated	regulate	VBN
cord-000248-zueoyesj	1270	34	androgen	androgen	NN
cord-000248-zueoyesj	1270	35	receptor	receptor	NN
cord-000248-zueoyesj	1270	36	transcriptional	transcriptional	NN
cord-000248-zueoyesj	1270	37	complex	complex	NN
cord-000248-zueoyesj	1270	38	in	in	IN
cord-000248-zueoyesj	1270	39	prostate	prostate	NN
cord-000248-zueoyesj	1270	40	cancer	cancer	NN
cord-000248-zueoyesj	1270	41	compared	compare	VBN
cord-000248-zueoyesj	1270	42	with	with	IN
cord-000248-zueoyesj	1270	43	normal	normal	JJ
cord-000248-zueoyesj	1270	44	prostate	prostate	NN
cord-000248-zueoyesj	1270	45	Suppression	suppression	NN
cord-000248-zueoyesj	1270	46	of	of	IN
cord-000248-zueoyesj	1270	47	FOXO1	FOXO1	NNP
cord-000248-zueoyesj	1270	48	activity	activity	NN
cord-000248-zueoyesj	1270	49	by	by	IN
cord-000248-zueoyesj	1270	50	FHL2	FHL2	NNP
cord-000248-zueoyesj	1270	51	through	through	IN
cord-000248-zueoyesj	1270	52	SIRT1-mediated	SIRT1-mediated	NNP
cord-000248-zueoyesj	1270	53	deacetylation	deacetylation	NN
cord-000248-zueoyesj	1271	1	The	the	DT
cord-000248-zueoyesj	1271	2	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1271	3	coactivator	coactivator	NN
cord-000248-zueoyesj	1271	4	FHL2	FHL2	NNP
cord-000248-zueoyesj	1271	5	transmits	transmit	VBZ
cord-000248-zueoyesj	1271	6	Rho	rho	NN
cord-000248-zueoyesj	1271	7	signals	signal	NNS
cord-000248-zueoyesj	1271	8	from	from	IN
cord-000248-zueoyesj	1271	9	the	the	DT
cord-000248-zueoyesj	1271	10	cell	cell	NN
cord-000248-zueoyesj	1271	11	membrane	membrane	NN
cord-000248-zueoyesj	1271	12	into	into	IN
cord-000248-zueoyesj	1271	13	the	the	DT
cord-000248-zueoyesj	1271	14	nucleus	nucleus	NN
cord-000248-zueoyesj	1272	1	Functional	functional	JJ
cord-000248-zueoyesj	1272	2	epigenomics	epigenomic	NNS
cord-000248-zueoyesj	1272	3	identifies	identify	VBZ
cord-000248-zueoyesj	1272	4	genes	gene	NNS
cord-000248-zueoyesj	1272	5	frequently	frequently	RB
cord-000248-zueoyesj	1272	6	silenced	silence	VBN
cord-000248-zueoyesj	1272	7	in	in	IN
cord-000248-zueoyesj	1272	8	prostate	prostate	NN
cord-000248-zueoyesj	1272	9	cancer	cancer	NN
cord-000248-zueoyesj	1272	10	Expression	expression	NN
cord-000248-zueoyesj	1272	11	level	level	NN
cord-000248-zueoyesj	1272	12	and	and	CC
cord-000248-zueoyesj	1272	13	DNA	dna	NN
cord-000248-zueoyesj	1272	14	methylation	methylation	NN
cord-000248-zueoyesj	1272	15	status	status	NN
cord-000248-zueoyesj	1272	16	of	of	IN
cord-000248-zueoyesj	1272	17	glutathione	glutathione	NN
cord-000248-zueoyesj	1272	18	-	-	HYPH
cord-000248-zueoyesj	1272	19	S	s	NN
cord-000248-zueoyesj	1272	20	-	-	HYPH
cord-000248-zueoyesj	1272	21	transferase	transferase	NN
cord-000248-zueoyesj	1272	22	genes	gene	NNS
cord-000248-zueoyesj	1272	23	in	in	IN
cord-000248-zueoyesj	1272	24	normal	normal	JJ
cord-000248-zueoyesj	1272	25	murine	murine	JJ
cord-000248-zueoyesj	1272	26	prostate	prostate	NN
cord-000248-zueoyesj	1272	27	and	and	CC
cord-000248-zueoyesj	1272	28	TRAMP	tramp	NN
cord-000248-zueoyesj	1272	29	tumors	tumor	NNS
cord-000248-zueoyesj	1272	30	Function	function	NN
cord-000248-zueoyesj	1272	31	of	of	IN
cord-000248-zueoyesj	1272	32	JunB	JunB	NNP
cord-000248-zueoyesj	1272	33	in	in	IN
cord-000248-zueoyesj	1272	34	transient	transient	JJ
cord-000248-zueoyesj	1272	35	amplifying	amplify	VBG
cord-000248-zueoyesj	1272	36	cell	cell	NN
cord-000248-zueoyesj	1272	37	senescence	senescence	NN
cord-000248-zueoyesj	1272	38	and	and	CC
cord-000248-zueoyesj	1272	39	progression	progression	NN
cord-000248-zueoyesj	1272	40	of	of	IN
cord-000248-zueoyesj	1272	41	human	human	JJ
cord-000248-zueoyesj	1272	42	prostate	prostate	NN
cord-000248-zueoyesj	1272	43	cancer	cancer	NN
cord-000248-zueoyesj	1272	44	KAI1	KAI1	NNP
cord-000248-zueoyesj	1272	45	promoter	promoter	NN
cord-000248-zueoyesj	1272	46	activity	activity	NN
cord-000248-zueoyesj	1272	47	is	be	VBZ
cord-000248-zueoyesj	1272	48	dependent	dependent	JJ
cord-000248-zueoyesj	1272	49	on	on	IN
cord-000248-zueoyesj	1272	50	p53	p53	NN
cord-000248-zueoyesj	1272	51	,	,	,
cord-000248-zueoyesj	1272	52	junB	junB	NNP
cord-000248-zueoyesj	1272	53	and	and	CC
cord-000248-zueoyesj	1272	54	AP2	AP2	NNP
cord-000248-zueoyesj	1272	55	:	:	:
cord-000248-zueoyesj	1272	56	evidence	evidence	NN
cord-000248-zueoyesj	1272	57	for	for	IN
cord-000248-zueoyesj	1272	58	a	a	DT
cord-000248-zueoyesj	1272	59	possible	possible	JJ
cord-000248-zueoyesj	1272	60	mechanism	mechanism	NN
cord-000248-zueoyesj	1272	61	underlying	underlying	JJ
cord-000248-zueoyesj	1272	62	loss	loss	NN
cord-000248-zueoyesj	1272	63	of	of	IN
cord-000248-zueoyesj	1272	64	KAI1	KAI1	NNP
cord-000248-zueoyesj	1272	65	expression	expression	NN
cord-000248-zueoyesj	1272	66	in	in	IN
cord-000248-zueoyesj	1272	67	cancer	cancer	NN
cord-000248-zueoyesj	1272	68	cells	cell	NNS
cord-000248-zueoyesj	1272	69	Inhibition	inhibition	NN
cord-000248-zueoyesj	1272	70	of	of	IN
cord-000248-zueoyesj	1272	71	prostate	prostate	NN
cord-000248-zueoyesj	1272	72	tumor	tumor	NN
cord-000248-zueoyesj	1272	73	growth	growth	NN
cord-000248-zueoyesj	1272	74	by	by	IN
cord-000248-zueoyesj	1272	75	overexpression	overexpression	NN
cord-000248-zueoyesj	1272	76	of	of	IN
cord-000248-zueoyesj	1272	77	NudC	NudC	NNP
cord-000248-zueoyesj	1272	78	,	,	,
cord-000248-zueoyesj	1272	79	a	a	DT
cord-000248-zueoyesj	1272	80	microtubule	microtubule	NN
cord-000248-zueoyesj	1272	81	motorassociated	motorassociate	VBN
cord-000248-zueoyesj	1272	82	protein	protein	NN
cord-000248-zueoyesj	1272	83	Control	Control	NNP
cord-000248-zueoyesj	1272	84	of	of	IN
cord-000248-zueoyesj	1272	85	androgen	androgen	NN
cord-000248-zueoyesj	1272	86	receptor	receptor	NN
cord-000248-zueoyesj	1272	87	signaling	signal	VBG
cord-000248-zueoyesj	1272	88	in	in	IN
cord-000248-zueoyesj	1272	89	prostate	prostate	NN
cord-000248-zueoyesj	1272	90	cancer	cancer	NN
cord-000248-zueoyesj	1272	91	by	by	IN
cord-000248-zueoyesj	1272	92	the	the	DT
cord-000248-zueoyesj	1272	93	cochaperone	cochaperone	NNP
cord-000248-zueoyesj	1272	94	small	small	JJ
cord-000248-zueoyesj	1272	95	glutamine	glutamine	NN
cord-000248-zueoyesj	1272	96	rich	rich	JJ
cord-000248-zueoyesj	1272	97	tetratricopeptide	tetratricopeptide	NN
cord-000248-zueoyesj	1272	98	repeat	repeat	NN
cord-000248-zueoyesj	1272	99	containing	contain	VBG
cord-000248-zueoyesj	1272	100	protein	protein	NN
cord-000248-zueoyesj	1272	101	alpha	alpha	NN
cord-000248-zueoyesj	1272	102	Signal	Signal	NNP
cord-000248-zueoyesj	1272	103	transducer	transducer	NN
cord-000248-zueoyesj	1272	104	and	and	CC
cord-000248-zueoyesj	1272	105	activator	activator	NN
cord-000248-zueoyesj	1272	106	of	of	IN
cord-000248-zueoyesj	1272	107	transcription-6	transcription-6	NNP
cord-000248-zueoyesj	1272	108	(	(	-LRB-
cord-000248-zueoyesj	1272	109	STAT6	STAT6	NNP
cord-000248-zueoyesj	1272	110	)	)	-RRB-
cord-000248-zueoyesj	1272	111	is	be	VBZ
cord-000248-zueoyesj	1272	112	a	a	DT
cord-000248-zueoyesj	1272	113	constitutively	constitutively	RB
cord-000248-zueoyesj	1272	114	expressed	express	VBN
cord-000248-zueoyesj	1272	115	survival	survival	NN
cord-000248-zueoyesj	1272	116	factor	factor	NN
cord-000248-zueoyesj	1272	117	in	in	IN
cord-000248-zueoyesj	1272	118	human	human	JJ
cord-000248-zueoyesj	1272	119	prostate	prostate	NN
cord-000248-zueoyesj	1272	120	cancer	cancer	NN
cord-000248-zueoyesj	1272	121	Robust	Robust	NNP
cord-000248-zueoyesj	1272	122	prostate	prostate	NN
cord-000248-zueoyesj	1272	123	cancer	cancer	NN
cord-000248-zueoyesj	1272	124	marker	marker	NN
cord-000248-zueoyesj	1272	125	genes	gene	NNS
cord-000248-zueoyesj	1272	126	emerge	emerge	VBP
cord-000248-zueoyesj	1272	127	from	from	IN
cord-000248-zueoyesj	1272	128	direct	direct	JJ
cord-000248-zueoyesj	1272	129	integration	integration	NN
cord-000248-zueoyesj	1272	130	of	of	IN
cord-000248-zueoyesj	1272	131	inter	inter	JJ
cord-000248-zueoyesj	1272	132	-	-	JJ
cord-000248-zueoyesj	1272	133	study	study	JJ
cord-000248-zueoyesj	1272	134	microarray	microarray	NN
cord-000248-zueoyesj	1272	135	data	datum	NNS
cord-000248-zueoyesj	1272	136	Molecular	Molecular	NNP
cord-000248-zueoyesj	1272	137	features	feature	NNS
cord-000248-zueoyesj	1272	138	of	of	IN
cord-000248-zueoyesj	1272	139	the	the	DT
cord-000248-zueoyesj	1272	140	transition	transition	NN
cord-000248-zueoyesj	1272	141	from	from	IN
cord-000248-zueoyesj	1272	142	prostatic	prostatic	JJ
cord-000248-zueoyesj	1272	143	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	1272	144	neoplasia	neoplasia	NN
cord-000248-zueoyesj	1272	145	(	(	-LRB-
cord-000248-zueoyesj	1272	146	PIN	pin	NN
cord-000248-zueoyesj	1272	147	)	)	-RRB-
cord-000248-zueoyesj	1272	148	to	to	IN
cord-000248-zueoyesj	1272	149	prostate	prostate	NN
cord-000248-zueoyesj	1272	150	cancer	cancer	NN
cord-000248-zueoyesj	1272	151	:	:	:
cord-000248-zueoyesj	1272	152	genome	genome	NN
cord-000248-zueoyesj	1272	153	-	-	HYPH
cord-000248-zueoyesj	1272	154	wide	wide	JJ
cord-000248-zueoyesj	1272	155	gene	gene	NN
cord-000248-zueoyesj	1272	156	-	-	HYPH
cord-000248-zueoyesj	1272	157	expression	expression	NN
cord-000248-zueoyesj	1272	158	profiles	profile	NNS
cord-000248-zueoyesj	1272	159	of	of	IN
cord-000248-zueoyesj	1272	160	prostate	prostate	NN
cord-000248-zueoyesj	1272	161	cancers	cancer	NNS
cord-000248-zueoyesj	1272	162	and	and	CC
cord-000248-zueoyesj	1272	163	PINs	pin	NNS
cord-000248-zueoyesj	1272	164	Analysis	Analysis	NNP
cord-000248-zueoyesj	1272	165	of	of	IN
cord-000248-zueoyesj	1272	166	integrin	integrin	NN
cord-000248-zueoyesj	1273	1	alpha7	alpha7	NN
cord-000248-zueoyesj	1273	2	mutations	mutation	NNS
cord-000248-zueoyesj	1273	3	in	in	IN
cord-000248-zueoyesj	1273	4	prostate	prostate	NN
cord-000248-zueoyesj	1273	5	cancer	cancer	NN
cord-000248-zueoyesj	1273	6	,	,	,
cord-000248-zueoyesj	1273	7	liver	liver	NN
cord-000248-zueoyesj	1273	8	cancer	cancer	NN
cord-000248-zueoyesj	1273	9	,	,	,
cord-000248-zueoyesj	1273	10	glioblastoma	glioblastoma	NN
cord-000248-zueoyesj	1273	11	multiforme	multiforme	NN
cord-000248-zueoyesj	1273	12	,	,	,
cord-000248-zueoyesj	1273	13	and	and	CC
cord-000248-zueoyesj	1273	14	leiomyosarcoma	leiomyosarcoma	NNP
cord-000248-zueoyesj	1274	1	The	the	DT
cord-000248-zueoyesj	1274	2	biology	biology	NN
cord-000248-zueoyesj	1274	3	of	of	IN
cord-000248-zueoyesj	1274	4	cancer	cancer	NN
cord-000248-zueoyesj	1275	1	The	the	DT
cord-000248-zueoyesj	1275	2	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1275	3	basis	basis	NN
cord-000248-zueoyesj	1275	4	of	of	IN
cord-000248-zueoyesj	1275	5	cancer	cancer	NN
cord-000248-zueoyesj	1275	6	Gene	Gene	NNP
cord-000248-zueoyesj	1275	7	panel	panel	NN
cord-000248-zueoyesj	1275	8	model	model	NN
cord-000248-zueoyesj	1275	9	predictive	predictive	NN
cord-000248-zueoyesj	1275	10	of	of	IN
cord-000248-zueoyesj	1275	11	outcome	outcome	NN
cord-000248-zueoyesj	1275	12	in	in	IN
cord-000248-zueoyesj	1275	13	men	man	NNS
cord-000248-zueoyesj	1275	14	at	at	IN
cord-000248-zueoyesj	1275	15	high	high	JJ
cord-000248-zueoyesj	1275	16	-	-	HYPH
cord-000248-zueoyesj	1275	17	risk	risk	NN
cord-000248-zueoyesj	1275	18	of	of	IN
cord-000248-zueoyesj	1275	19	systemic	systemic	JJ
cord-000248-zueoyesj	1275	20	progression	progression	NN
cord-000248-zueoyesj	1275	21	and	and	CC
cord-000248-zueoyesj	1275	22	death	death	NN
cord-000248-zueoyesj	1275	23	from	from	IN
cord-000248-zueoyesj	1275	24	prostate	prostate	NN
cord-000248-zueoyesj	1275	25	cancer	cancer	NN
cord-000248-zueoyesj	1275	26	after	after	IN
cord-000248-zueoyesj	1275	27	radical	radical	JJ
cord-000248-zueoyesj	1275	28	retropubic	retropubic	JJ
cord-000248-zueoyesj	1275	29	prostatectomy	prostatectomy	NN
cord-000248-zueoyesj	1275	30	Aneuploidy	Aneuploidy	NNP
cord-000248-zueoyesj	1275	31	and	and	CC
cord-000248-zueoyesj	1275	32	rapid	rapid	JJ
cord-000248-zueoyesj	1275	33	cell	cell	NN
cord-000248-zueoyesj	1275	34	proliferation	proliferation	NN
cord-000248-zueoyesj	1275	35	in	in	IN
cord-000248-zueoyesj	1275	36	recurrent	recurrent	JJ
cord-000248-zueoyesj	1275	37	prostate	prostate	NN
cord-000248-zueoyesj	1275	38	cancers	cancer	NNS
cord-000248-zueoyesj	1275	39	with	with	IN
cord-000248-zueoyesj	1275	40	androgen	androgen	NN
cord-000248-zueoyesj	1275	41	receptor	receptor	NN
cord-000248-zueoyesj	1275	42	gene	gene	NN
cord-000248-zueoyesj	1275	43	amplification	amplification	NN
cord-000248-zueoyesj	1275	44	Prognostic	prognostic	JJ
cord-000248-zueoyesj	1275	45	value	value	NN
cord-000248-zueoyesj	1275	46	of	of	IN
cord-000248-zueoyesj	1275	47	DNA	dna	NN
cord-000248-zueoyesj	1275	48	analysis	analysis	NN
cord-000248-zueoyesj	1275	49	of	of	IN
cord-000248-zueoyesj	1275	50	prostate	prostate	NN
cord-000248-zueoyesj	1275	51	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1275	52	:	:	:
cord-000248-zueoyesj	1275	53	correlation	correlation	NN
cord-000248-zueoyesj	1275	54	to	to	IN
cord-000248-zueoyesj	1275	55	clinicopathologic	clinicopathologic	JJ
cord-000248-zueoyesj	1275	56	predictors	predictor	NNS
cord-000248-zueoyesj	1275	57	Heterogeneity	Heterogeneity	NNP
cord-000248-zueoyesj	1275	58	in	in	IN
cord-000248-zueoyesj	1275	59	prostate	prostate	NN
cord-000248-zueoyesj	1275	60	cancer	cancer	NN
cord-000248-zueoyesj	1275	61	:	:	:
cord-000248-zueoyesj	1275	62	prostate	prostate	NN
cord-000248-zueoyesj	1275	63	specific	specific	JJ
cord-000248-zueoyesj	1275	64	antigen	antigen	NN
cord-000248-zueoyesj	1275	65	(	(	-LRB-
cord-000248-zueoyesj	1275	66	PSA	PSA	NNP
cord-000248-zueoyesj	1275	67	)	)	-RRB-
cord-000248-zueoyesj	1275	68	and	and	CC
cord-000248-zueoyesj	1275	69	DNA	DNA	NNP
cord-000248-zueoyesj	1275	70	cytophotometry	cytophotometry	NN
cord-000248-zueoyesj	1275	71	Identification	identification	NN
cord-000248-zueoyesj	1275	72	of	of	IN
cord-000248-zueoyesj	1275	73	patients	patient	NNS
cord-000248-zueoyesj	1275	74	with	with	IN
cord-000248-zueoyesj	1275	75	low	low	JJ
cord-000248-zueoyesj	1275	76	-	-	HYPH
cord-000248-zueoyesj	1275	77	risk	risk	NN
cord-000248-zueoyesj	1275	78	for	for	IN
cord-000248-zueoyesj	1275	79	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1275	80	:	:	:
cord-000248-zueoyesj	1275	81	comparative	comparative	JJ
cord-000248-zueoyesj	1275	82	discriminatory	discriminatory	JJ
cord-000248-zueoyesj	1275	83	models	model	NNS
cord-000248-zueoyesj	1275	84	using	use	VBG
cord-000248-zueoyesj	1275	85	linear	linear	JJ
cord-000248-zueoyesj	1275	86	and	and	CC
cord-000248-zueoyesj	1275	87	machinelearning	machinelearne	VBG
cord-000248-zueoyesj	1275	88	classifiers	classifier	NNS
cord-000248-zueoyesj	1275	89	in	in	IN
cord-000248-zueoyesj	1275	90	prostate	prostate	NN
cord-000248-zueoyesj	1275	91	cancer	cancer	NN
cord-000248-zueoyesj	1275	92	Prognostic	prognostic	JJ
cord-000248-zueoyesj	1275	93	factors	factor	NNS
cord-000248-zueoyesj	1275	94	in	in	IN
cord-000248-zueoyesj	1275	95	prostate	prostate	NN
cord-000248-zueoyesj	1275	96	cancer	cancer	NN
cord-000248-zueoyesj	1275	97	Stage	stage	NN
cord-000248-zueoyesj	1275	98	B	B	NNP
cord-000248-zueoyesj	1275	99	Prostate	Prostate	NNP
cord-000248-zueoyesj	1275	100	Cancer	cancer	NN
cord-000248-zueoyesj	1275	101	:	:	:
cord-000248-zueoyesj	1275	102	Correlation	correlation	NN
cord-000248-zueoyesj	1275	103	of	of	IN
cord-000248-zueoyesj	1275	104	DNA	DNA	NNP
cord-000248-zueoyesj	1275	105	Ploidy	Ploidy	NNP
cord-000248-zueoyesj	1275	106	Analysis	Analysis	NNP
cord-000248-zueoyesj	1275	107	With	with	IN
cord-000248-zueoyesj	1275	108	Histological	Histological	NNP
cord-000248-zueoyesj	1275	109	and	and	CC
cord-000248-zueoyesj	1275	110	Clinical	Clinical	NNP
cord-000248-zueoyesj	1275	111	Parameters	Parameters	NNP
cord-000248-zueoyesj	1275	112	ETS	ETS	NNP
cord-000248-zueoyesj	1275	113	gene	gene	NN
cord-000248-zueoyesj	1275	114	fusions	fusion	NNS
cord-000248-zueoyesj	1275	115	in	in	IN
cord-000248-zueoyesj	1275	116	prostate	prostate	NN
cord-000248-zueoyesj	1275	117	cancer	cancer	NN
cord-000248-zueoyesj	1275	118	Unusually	unusually	RB
cord-000248-zueoyesj	1275	119	stable	stable	JJ
cord-000248-zueoyesj	1275	120	abnormal	abnormal	JJ
cord-000248-zueoyesj	1275	121	karyotype	karyotype	NN
cord-000248-zueoyesj	1275	122	in	in	IN
cord-000248-zueoyesj	1275	123	a	a	DT
cord-000248-zueoyesj	1275	124	highly	highly	RB
cord-000248-zueoyesj	1275	125	aggressive	aggressive	JJ
cord-000248-zueoyesj	1275	126	melanoma	melanoma	NN
cord-000248-zueoyesj	1275	127	negative	negative	JJ
cord-000248-zueoyesj	1275	128	for	for	IN
cord-000248-zueoyesj	1275	129	telomerase	telomerase	NN
cord-000248-zueoyesj	1275	130	activity	activity	NN
cord-000248-zueoyesj	1275	131	Repetitive	repetitive	JJ
cord-000248-zueoyesj	1275	132	DNA	dna	NN
cord-000248-zueoyesj	1275	133	alterations	alteration	NNS
cord-000248-zueoyesj	1275	134	in	in	IN
cord-000248-zueoyesj	1275	135	human	human	JJ
cord-000248-zueoyesj	1275	136	skin	skin	NN
cord-000248-zueoyesj	1275	137	cancers	cancer	NNS
cord-000248-zueoyesj	1276	1	Emerging	emerge	VBG
cord-000248-zueoyesj	1276	2	insights	insight	NNS
cord-000248-zueoyesj	1276	3	into	into	IN
cord-000248-zueoyesj	1276	4	the	the	DT
cord-000248-zueoyesj	1276	5	molecular	molecular	JJ
cord-000248-zueoyesj	1276	6	pathogenesis	pathogenesis	NN
cord-000248-zueoyesj	1276	7	of	of	IN
cord-000248-zueoyesj	1276	8	uveal	uveal	JJ
cord-000248-zueoyesj	1276	9	melanoma	melanoma	NN
cord-000248-zueoyesj	1276	10	Integrative	Integrative	NNP
cord-000248-zueoyesj	1276	11	genomic	genomic	JJ
cord-000248-zueoyesj	1276	12	analysis	analysis	NN
cord-000248-zueoyesj	1276	13	of	of	IN
cord-000248-zueoyesj	1276	14	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1276	15	in	in	IN
cord-000248-zueoyesj	1276	16	uveal	uveal	JJ
cord-000248-zueoyesj	1276	17	melanoma	melanoma	NN
cord-000248-zueoyesj	1276	18	Decreased	decrease	VBD
cord-000248-zueoyesj	1276	19	DNA	dna	NN
cord-000248-zueoyesj	1276	20	ploidy	ploidy	NN
cord-000248-zueoyesj	1276	21	may	may	MD
cord-000248-zueoyesj	1276	22	constitute	constitute	VB
cord-000248-zueoyesj	1276	23	a	a	DT
cord-000248-zueoyesj	1276	24	mechanism	mechanism	NN
cord-000248-zueoyesj	1276	25	of	of	IN
cord-000248-zueoyesj	1276	26	the	the	DT
cord-000248-zueoyesj	1276	27	reduced	reduce	VBN
cord-000248-zueoyesj	1276	28	malignant	malignant	JJ
cord-000248-zueoyesj	1276	29	behavior	behavior	NN
cord-000248-zueoyesj	1276	30	of	of	IN
cord-000248-zueoyesj	1276	31	B16	B16	NNP
cord-000248-zueoyesj	1276	32	melanoma	melanoma	NN
cord-000248-zueoyesj	1276	33	in	in	IN
cord-000248-zueoyesj	1276	34	aged	aged	JJ
cord-000248-zueoyesj	1276	35	mice	mouse	NNS
cord-000248-zueoyesj	1276	36	High	high	JJ
cord-000248-zueoyesj	1276	37	frequency	frequency	NN
cord-000248-zueoyesj	1276	38	of	of	IN
cord-000248-zueoyesj	1276	39	tetraploidy	tetraploidy	NN
cord-000248-zueoyesj	1276	40	detected	detect	VBN
cord-000248-zueoyesj	1276	41	in	in	IN
cord-000248-zueoyesj	1276	42	malignant	malignant	JJ
cord-000248-zueoyesj	1276	43	melanoma	melanoma	NN
cord-000248-zueoyesj	1276	44	of	of	IN
cord-000248-zueoyesj	1276	45	Japanese	japanese	JJ
cord-000248-zueoyesj	1276	46	patients	patient	NNS
cord-000248-zueoyesj	1276	47	by	by	IN
cord-000248-zueoyesj	1276	48	fluorescence	fluorescence	NN
cord-000248-zueoyesj	1276	49	in	in	IN
cord-000248-zueoyesj	1276	50	situ	situ	NN
cord-000248-zueoyesj	1276	51	hybridization	hybridization	NN
cord-000248-zueoyesj	1276	52	Analysis	Analysis	NNP
cord-000248-zueoyesj	1276	53	of	of	IN
cord-000248-zueoyesj	1276	54	the	the	DT
cord-000248-zueoyesj	1276	55	DNA	dna	NN
cord-000248-zueoyesj	1276	56	content	content	NN
cord-000248-zueoyesj	1276	57	in	in	IN
cord-000248-zueoyesj	1276	58	the	the	DT
cord-000248-zueoyesj	1276	59	progression	progression	NN
cord-000248-zueoyesj	1276	60	of	of	IN
cord-000248-zueoyesj	1276	61	recurrent	recurrent	JJ
cord-000248-zueoyesj	1276	62	and	and	CC
cord-000248-zueoyesj	1276	63	metastatic	metastatic	JJ
cord-000248-zueoyesj	1276	64	melanomas	melanoma	NNS
cord-000248-zueoyesj	1276	65	Evaluation	Evaluation	NNP
cord-000248-zueoyesj	1276	66	of	of	IN
cord-000248-zueoyesj	1276	67	DNA	dna	NN
cord-000248-zueoyesj	1276	68	ploidy	ploidy	NN
cord-000248-zueoyesj	1276	69	and	and	CC
cord-000248-zueoyesj	1276	70	degree	degree	NN
cord-000248-zueoyesj	1276	71	of	of	IN
cord-000248-zueoyesj	1276	72	DNA	dna	NN
cord-000248-zueoyesj	1276	73	abnormality	abnormality	NN
cord-000248-zueoyesj	1276	74	in	in	IN
cord-000248-zueoyesj	1276	75	benign	benign	JJ
cord-000248-zueoyesj	1276	76	and	and	CC
cord-000248-zueoyesj	1276	77	malignant	malignant	JJ
cord-000248-zueoyesj	1276	78	melanocytic	melanocytic	JJ
cord-000248-zueoyesj	1276	79	lesions	lesion	NNS
cord-000248-zueoyesj	1276	80	of	of	IN
cord-000248-zueoyesj	1276	81	the	the	DT
cord-000248-zueoyesj	1276	82	skin	skin	NN
cord-000248-zueoyesj	1276	83	using	use	VBG
cord-000248-zueoyesj	1276	84	video	video	NN
cord-000248-zueoyesj	1276	85	imaging	imaging	NNP
cord-000248-zueoyesj	1276	86	Association	Association	NNP
cord-000248-zueoyesj	1276	87	of	of	IN
cord-000248-zueoyesj	1276	88	genomic	genomic	JJ
cord-000248-zueoyesj	1276	89	imbalances	imbalance	NNS
cord-000248-zueoyesj	1276	90	with	with	IN
cord-000248-zueoyesj	1276	91	resistance	resistance	NN
cord-000248-zueoyesj	1276	92	to	to	IN
cord-000248-zueoyesj	1276	93	therapeutic	therapeutic	JJ
cord-000248-zueoyesj	1276	94	drugs	drug	NNS
cord-000248-zueoyesj	1276	95	in	in	IN
cord-000248-zueoyesj	1276	96	human	human	JJ
cord-000248-zueoyesj	1276	97	melanoma	melanoma	NN
cord-000248-zueoyesj	1276	98	cell	cell	NN
cord-000248-zueoyesj	1276	99	lines	line	NNS
cord-000248-zueoyesj	1276	100	Highgrade	highgrade	JJ
cord-000248-zueoyesj	1276	101	prostate	prostate	NN
cord-000248-zueoyesj	1276	102	intraepithelial	intraepithelial	JJ
cord-000248-zueoyesj	1276	103	neoplasia	neoplasia	NN
cord-000248-zueoyesj	1276	104	shares	share	NNS
cord-000248-zueoyesj	1276	105	cytogenetic	cytogenetic	JJ
cord-000248-zueoyesj	1276	106	alterations	alteration	NNS
cord-000248-zueoyesj	1276	107	with	with	IN
cord-000248-zueoyesj	1276	108	invasive	invasive	JJ
cord-000248-zueoyesj	1276	109	prostate	prostate	NN
cord-000248-zueoyesj	1276	110	cancer	cancer	NN
cord-000248-zueoyesj	1276	111	Persistent	persistent	JJ
cord-000248-zueoyesj	1276	112	exposure	exposure	NN
cord-000248-zueoyesj	1276	113	to	to	IN
cord-000248-zueoyesj	1276	114	Mycoplasma	Mycoplasma	NNP
cord-000248-zueoyesj	1276	115	induces	induce	VBZ
cord-000248-zueoyesj	1276	116	malignant	malignant	JJ
cord-000248-zueoyesj	1276	117	transformation	transformation	NN
cord-000248-zueoyesj	1276	118	of	of	IN
cord-000248-zueoyesj	1276	119	human	human	JJ
cord-000248-zueoyesj	1276	120	prostate	prostate	NN
cord-000248-zueoyesj	1276	121	cells	cell	NNS
cord-000248-zueoyesj	1276	122	Profiling	profile	VBG
cord-000248-zueoyesj	1276	123	cytogenetic	cytogenetic	JJ
cord-000248-zueoyesj	1276	124	diversity	diversity	NN
cord-000248-zueoyesj	1276	125	with	with	IN
cord-000248-zueoyesj	1276	126	entropy	entropy	NN
cord-000248-zueoyesj	1276	127	-	-	HYPH
cord-000248-zueoyesj	1276	128	based	base	VBN
cord-000248-zueoyesj	1276	129	karyotypic	karyotypic	NNP
cord-000248-zueoyesj	1276	130	analysis	analysis	NNP
cord-000248-zueoyesj	1277	1	A	a	DT
cord-000248-zueoyesj	1277	2	Farewell	Farewell	NNP
cord-000248-zueoyesj	1277	3	to	to	IN
cord-000248-zueoyesj	1277	4	Entropy	Entropy	NNP
cord-000248-zueoyesj	1277	5	:	:	:
cord-000248-zueoyesj	1277	6	Statistical	Statistical	NNP
cord-000248-zueoyesj	1277	7	Thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	1277	8	based	base	VBN
cord-000248-zueoyesj	1277	9	on	on	IN
cord-000248-zueoyesj	1277	10	Information	Information	NNP
cord-000248-zueoyesj	1277	11	World	World	NNP
cord-000248-zueoyesj	1278	1	Can	Can	MD
cord-000248-zueoyesj	1278	2	Entropy	entropy	VB
cord-000248-zueoyesj	1278	3	and	and	CC
cord-000248-zueoyesj	1278	4	'	'	''
cord-000248-zueoyesj	1278	5	'	'	``
cord-000248-zueoyesj	1278	6	order	order	NN
cord-000248-zueoyesj	1278	7	'	'	''
cord-000248-zueoyesj	1278	8	'	'	''
cord-000248-zueoyesj	1278	9	increase	increase	NN
cord-000248-zueoyesj	1278	10	together	together	RB
cord-000248-zueoyesj	1278	11	?	?	.
cord-000248-zueoyesj	1279	1	Entropy	entropy	NN
cord-000248-zueoyesj	1279	2	measures	measure	NNS
cord-000248-zueoyesj	1279	3	quantify	quantify	VBP
cord-000248-zueoyesj	1279	4	global	global	JJ
cord-000248-zueoyesj	1279	5	splicing	splicing	NN
cord-000248-zueoyesj	1279	6	disorders	disorder	NNS
cord-000248-zueoyesj	1279	7	in	in	IN
cord-000248-zueoyesj	1279	8	cancer	cancer	NN
cord-000248-zueoyesj	1279	9	Computing	compute	VBG
cord-000248-zueoyesj	1279	10	the	the	DT
cord-000248-zueoyesj	1279	11	optimal	optimal	JJ
cord-000248-zueoyesj	1279	12	protocol	protocol	NN
cord-000248-zueoyesj	1279	13	for	for	IN
cord-000248-zueoyesj	1279	14	finite	finite	JJ
cord-000248-zueoyesj	1279	15	-	-	HYPH
cord-000248-zueoyesj	1279	16	time	time	NN
cord-000248-zueoyesj	1279	17	processes	process	NNS
cord-000248-zueoyesj	1279	18	in	in	IN
cord-000248-zueoyesj	1279	19	stochastic	stochastic	JJ
cord-000248-zueoyesj	1279	20	thermodynamics	thermodynamic	NNS
cord-000248-zueoyesj	1280	1	Optimal	optimal	JJ
cord-000248-zueoyesj	1280	2	finite	finite	JJ
cord-000248-zueoyesj	1280	3	-	-	HYPH
cord-000248-zueoyesj	1280	4	time	time	NN
cord-000248-zueoyesj	1280	5	endoreversible	endoreversible	JJ
cord-000248-zueoyesj	1280	6	processes	process	NNS
cord-000248-zueoyesj	1280	7	Optimal	Optimal	NNP
cord-000248-zueoyesj	1280	8	process	process	NN
cord-000248-zueoyesj	1280	9	paths	path	NNS
cord-000248-zueoyesj	1280	10	for	for	IN
cord-000248-zueoyesj	1280	11	endoreversible	endoreversible	JJ
cord-000248-zueoyesj	1280	12	systems	system	NNS
cord-000248-zueoyesj	1280	13	Altered	alter	VBN
cord-000248-zueoyesj	1280	14	mode	mode	NN
cord-000248-zueoyesj	1280	15	of	of	IN
cord-000248-zueoyesj	1280	16	allelic	allelic	JJ
cord-000248-zueoyesj	1280	17	replication	replication	NN
cord-000248-zueoyesj	1280	18	accompanied	accompany	VBN
cord-000248-zueoyesj	1280	19	by	by	IN
cord-000248-zueoyesj	1280	20	aneuploidy	aneuploidy	NN
cord-000248-zueoyesj	1280	21	in	in	IN
cord-000248-zueoyesj	1280	22	peripheral	peripheral	JJ
cord-000248-zueoyesj	1280	23	blood	blood	NN
cord-000248-zueoyesj	1280	24	lymphocytes	lymphocyte	NNS
cord-000248-zueoyesj	1280	25	of	of	IN
cord-000248-zueoyesj	1280	26	prostate	prostate	NN
cord-000248-zueoyesj	1280	27	cancer	cancer	NN
cord-000248-zueoyesj	1280	28	patients	patient	NNS
cord-000248-zueoyesj	1281	1	A	a	DT
cord-000248-zueoyesj	1281	2	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1281	3	interpretation	interpretation	NN
cord-000248-zueoyesj	1281	4	of	of	IN
cord-000248-zueoyesj	1281	5	malignancy	malignancy	NN
cord-000248-zueoyesj	1281	6	:	:	:
cord-000248-zueoyesj	1281	7	do	do	VB
cord-000248-zueoyesj	1281	8	the	the	DT
cord-000248-zueoyesj	1281	9	genes	gene	NNS
cord-000248-zueoyesj	1281	10	come	come	VB
cord-000248-zueoyesj	1281	11	later	later	RB
cord-000248-zueoyesj	1281	12	?	?	.
cord-000248-zueoyesj	1282	1	The	the	DT
cord-000248-zueoyesj	1282	2	storage	storage	NN
cord-000248-zueoyesj	1282	3	of	of	IN
cord-000248-zueoyesj	1282	4	energy	energy	NN
cord-000248-zueoyesj	1282	5	as	as	IN
cord-000248-zueoyesj	1282	6	a	a	DT
cord-000248-zueoyesj	1282	7	cause	cause	NN
cord-000248-zueoyesj	1282	8	of	of	IN
cord-000248-zueoyesj	1282	9	malignant	malignant	JJ
cord-000248-zueoyesj	1282	10	transformation	transformation	NN
cord-000248-zueoyesj	1282	11	:	:	:
cord-000248-zueoyesj	1282	12	a	a	DT
cord-000248-zueoyesj	1282	13	7-phase	7-phase	CD
cord-000248-zueoyesj	1282	14	model	model	NN
cord-000248-zueoyesj	1282	15	of	of	IN
cord-000248-zueoyesj	1282	16	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1282	17	Biology	biology	NN
cord-000248-zueoyesj	1282	18	of	of	IN
cord-000248-zueoyesj	1282	19	cancer	cancer	NN
cord-000248-zueoyesj	1282	20	:	:	:
cord-000248-zueoyesj	1282	21	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1282	22	answers	answer	NNS
cord-000248-zueoyesj	1282	23	to	to	IN
cord-000248-zueoyesj	1282	24	some	some	DT
cord-000248-zueoyesj	1282	25	questions	question	NNS
cord-000248-zueoyesj	1282	26	Cervical	cervical	JJ
cord-000248-zueoyesj	1282	27	cancer	cancer	NN
cord-000248-zueoyesj	1282	28	as	as	IN
cord-000248-zueoyesj	1282	29	a	a	DT
cord-000248-zueoyesj	1282	30	natural	natural	JJ
cord-000248-zueoyesj	1282	31	phenomenon	phenomenon	NN
cord-000248-zueoyesj	1282	32	Information	information	NN
cord-000248-zueoyesj	1282	33	of	of	IN
cord-000248-zueoyesj	1282	34	genome	genome	NN
cord-000248-zueoyesj	1282	35	sequences	sequence	NNS
cord-000248-zueoyesj	1282	36	and	and	CC
cord-000248-zueoyesj	1282	37	molecular	molecular	JJ
cord-000248-zueoyesj	1282	38	basis	basis	NN
cord-000248-zueoyesj	1282	39	of	of	IN
cord-000248-zueoyesj	1282	40	cancer	cancer	NN
cord-000248-zueoyesj	1282	41	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1282	42	's	's	POS
cord-000248-zueoyesj	1282	43	demon	demon	NN
cord-000248-zueoyesj	1282	44	and	and	CC
cord-000248-zueoyesj	1282	45	Smoluchowski	Smoluchowski	NNP
cord-000248-zueoyesj	1282	46	's	's	POS
cord-000248-zueoyesj	1282	47	trap	trap	NN
cord-000248-zueoyesj	1282	48	door	door	NN
cord-000248-zueoyesj	1282	49	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1282	50	's	's	POS
cord-000248-zueoyesj	1282	51	demon	demon	NN
cord-000248-zueoyesj	1282	52	assisted	assist	VBD
cord-000248-zueoyesj	1282	53	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1282	54	cycle	cycle	NN
cord-000248-zueoyesj	1282	55	in	in	IN
cord-000248-zueoyesj	1282	56	superconducting	superconducte	VBG
cord-000248-zueoyesj	1282	57	quantum	quantum	NN
cord-000248-zueoyesj	1282	58	circuits	circuit	NNS
cord-000248-zueoyesj	1283	1	Ponderomotive	ponderomotive	JJ
cord-000248-zueoyesj	1283	2	ratchet	ratchet	NN
cord-000248-zueoyesj	1283	3	in	in	IN
cord-000248-zueoyesj	1283	4	a	a	DT
cord-000248-zueoyesj	1283	5	uniform	uniform	JJ
cord-000248-zueoyesj	1283	6	magnetic	magnetic	JJ
cord-000248-zueoyesj	1283	7	field	field	NN
cord-000248-zueoyesj	1283	8	Protein	Protein	NNP
cord-000248-zueoyesj	1283	9	folding	folding	NN
cord-000248-zueoyesj	1283	10	and	and	CC
cord-000248-zueoyesj	1283	11	evolution	evolution	NN
cord-000248-zueoyesj	1283	12	are	be	VBP
cord-000248-zueoyesj	1283	13	driven	drive	VBN
cord-000248-zueoyesj	1283	14	by	by	IN
cord-000248-zueoyesj	1283	15	the	the	DT
cord-000248-zueoyesj	1283	16	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1283	17	Demon	Demon	NNP
cord-000248-zueoyesj	1283	18	activity	activity	NN
cord-000248-zueoyesj	1283	19	of	of	IN
cord-000248-zueoyesj	1283	20	proteins	protein	NNS
cord-000248-zueoyesj	1283	21	Current	current	JJ
cord-000248-zueoyesj	1283	22	drive	drive	NN
cord-000248-zueoyesj	1283	23	in	in	IN
cord-000248-zueoyesj	1283	24	a	a	DT
cord-000248-zueoyesj	1283	25	ponderomotive	ponderomotive	JJ
cord-000248-zueoyesj	1283	26	potential	potential	NN
cord-000248-zueoyesj	1283	27	with	with	IN
cord-000248-zueoyesj	1283	28	sign	sign	NN
cord-000248-zueoyesj	1283	29	reversal	reversal	NN
cord-000248-zueoyesj	1283	30	Global	Global	NNP
cord-000248-zueoyesj	1283	31	and	and	CC
cord-000248-zueoyesj	1283	32	local	local	JJ
cord-000248-zueoyesj	1283	33	)	)	-RRB-
cord-000248-zueoyesj	1283	34	fluctuations	fluctuation	NNS
cord-000248-zueoyesj	1283	35	of	of	IN
cord-000248-zueoyesj	1283	36	phase	phase	NN
cord-000248-zueoyesj	1283	37	space	space	NN
cord-000248-zueoyesj	1283	38	contraction	contraction	NN
cord-000248-zueoyesj	1283	39	in	in	IN
cord-000248-zueoyesj	1283	40	deterministic	deterministic	JJ
cord-000248-zueoyesj	1283	41	stationary	stationary	JJ
cord-000248-zueoyesj	1283	42	nonequilibrium	nonequilibrium	JJ
cord-000248-zueoyesj	1284	1	The	the	DT
cord-000248-zueoyesj	1284	2	Szilard	Szilard	NNP
cord-000248-zueoyesj	1284	3	engine	engine	NN
cord-000248-zueoyesj	1284	4	revisited	revisit	VBD
cord-000248-zueoyesj	1284	5	:	:	:
cord-000248-zueoyesj	1285	1	Entropy	entropy	NN
cord-000248-zueoyesj	1285	2	,	,	,
cord-000248-zueoyesj	1285	3	macroscopic	macroscopic	JJ
cord-000248-zueoyesj	1285	4	randomness	randomness	NN
cord-000248-zueoyesj	1285	5	,	,	,
cord-000248-zueoyesj	1285	6	and	and	CC
cord-000248-zueoyesj	1285	7	symmetry	symmetry	NN
cord-000248-zueoyesj	1285	8	breaking	breaking	NN
cord-000248-zueoyesj	1285	9	phase	phase	NN
cord-000248-zueoyesj	1285	10	transitions	transition	NNS
cord-000248-zueoyesj	1285	11	Hydrodynamic	Hydrodynamic	NNP
cord-000248-zueoyesj	1285	12	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1285	13	demon	demon	NN
cord-000248-zueoyesj	1285	14	in	in	IN
cord-000248-zueoyesj	1285	15	granular	granular	JJ
cord-000248-zueoyesj	1285	16	systems	system	NNS
cord-000248-zueoyesj	1285	17	Evolution	evolution	NN
cord-000248-zueoyesj	1285	18	of	of	IN
cord-000248-zueoyesj	1285	19	biological	biological	JJ
cord-000248-zueoyesj	1285	20	complexity	complexity	NN
cord-000248-zueoyesj	1285	21	Adaptation	adaptation	NN
cord-000248-zueoyesj	1285	22	and	and	CC
cord-000248-zueoyesj	1285	23	information	information	NN
cord-000248-zueoyesj	1285	24	in	in	IN
cord-000248-zueoyesj	1285	25	ontogenesis	ontogenesis	NN
cord-000248-zueoyesj	1285	26	and	and	CC
cord-000248-zueoyesj	1285	27	phylogenesis	phylogenesis	NN
cord-000248-zueoyesj	1285	28	.	.	.
cord-000248-zueoyesj	1286	1	Increase	increase	NN
cord-000248-zueoyesj	1286	2	of	of	IN
cord-000248-zueoyesj	1286	3	complexity	complexity	NN
cord-000248-zueoyesj	1286	4	and	and	CC
cord-000248-zueoyesj	1286	5	efficiency	efficiency	NN
cord-000248-zueoyesj	1286	6	Use	use	NN
cord-000248-zueoyesj	1286	7	of	of	IN
cord-000248-zueoyesj	1286	8	glucose	glucose	NN
cord-000248-zueoyesj	1286	9	6-phosphate	6-phosphate	NN
cord-000248-zueoyesj	1286	10	and	and	CC
cord-000248-zueoyesj	1286	11	hexokinase	hexokinase	NN
cord-000248-zueoyesj	1286	12	as	as	IN
cord-000248-zueoyesj	1286	13	an	an	DT
cord-000248-zueoyesj	1286	14	ATP	ATP	NNP
cord-000248-zueoyesj	1286	15	regenerating	regenerate	VBG
cord-000248-zueoyesj	1286	16	system	system	NN
cord-000248-zueoyesj	1286	17	by	by	IN
cord-000248-zueoyesj	1286	18	the	the	DT
cord-000248-zueoyesj	1286	19	Ca(2+)-ATPase	Ca(2+)-ATPase	NNP
cord-000248-zueoyesj	1286	20	of	of	IN
cord-000248-zueoyesj	1286	21	sarcoplasmic	sarcoplasmic	JJ
cord-000248-zueoyesj	1286	22	reticulum	reticulum	NN
cord-000248-zueoyesj	1286	23	and	and	CC
cord-000248-zueoyesj	1286	24	submitochondrial	submitochondrial	JJ
cord-000248-zueoyesj	1286	25	particles	particle	NNS
cord-000248-zueoyesj	1287	1	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1287	2	's	's	POS
cord-000248-zueoyesj	1287	3	Demon	Demon	NNP
cord-000248-zueoyesj	1287	4	Anderson	Anderson	NNP
cord-000248-zueoyesj	1287	5	PW	PW	NNP
cord-000248-zueoyesj	1287	6	Comment	comment	NN
cord-000248-zueoyesj	1287	7	on	on	IN
cord-000248-zueoyesj	1287	8	''	''	''
cord-000248-zueoyesj	1288	1	Quantitative	quantitative	JJ
cord-000248-zueoyesj	1288	2	limits	limit	NNS
cord-000248-zueoyesj	1288	3	on	on	IN
cord-000248-zueoyesj	1288	4	the	the	DT
cord-000248-zueoyesj	1288	5	ability	ability	NN
cord-000248-zueoyesj	1288	6	of	of	IN
cord-000248-zueoyesj	1288	7	a	a	DT
cord-000248-zueoyesj	1288	8	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1288	9	demon	demon	NN
cord-000248-zueoyesj	1288	10	to	to	TO
cord-000248-zueoyesj	1288	11	extract	extract	VB
cord-000248-zueoyesj	1288	12	work	work	NN
cord-000248-zueoyesj	1288	13	from	from	IN
cord-000248-zueoyesj	1288	14	heat	heat	NN
cord-000248-zueoyesj	1288	15	Quantitative	quantitative	JJ
cord-000248-zueoyesj	1288	16	limits	limit	NNS
cord-000248-zueoyesj	1288	17	on	on	IN
cord-000248-zueoyesj	1288	18	the	the	DT
cord-000248-zueoyesj	1288	19	ability	ability	NN
cord-000248-zueoyesj	1288	20	of	of	IN
cord-000248-zueoyesj	1288	21	a	a	DT
cord-000248-zueoyesj	1288	22	Maxwell	Maxwell	NNP
cord-000248-zueoyesj	1288	23	demon	demon	NN
cord-000248-zueoyesj	1288	24	to	to	TO
cord-000248-zueoyesj	1288	25	extract	extract	VB
cord-000248-zueoyesj	1288	26	work	work	NN
cord-000248-zueoyesj	1288	27	from	from	IN
cord-000248-zueoyesj	1288	28	heat	heat	NN
cord-000248-zueoyesj	1288	29	Folding	folding	NN
cord-000248-zueoyesj	1288	30	and	and	CC
cord-000248-zueoyesj	1288	31	misfolding	misfolde	VBG
cord-000248-zueoyesj	1288	32	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1288	33	of	of	IN
cord-000248-zueoyesj	1288	34	the	the	DT
cord-000248-zueoyesj	1288	35	p53	p53	NN
cord-000248-zueoyesj	1288	36	DNA	dna	NN
cord-000248-zueoyesj	1288	37	binding	binding	NN
cord-000248-zueoyesj	1288	38	domain	domain	NN
cord-000248-zueoyesj	1288	39	at	at	IN
cord-000248-zueoyesj	1288	40	physiological	physiological	JJ
cord-000248-zueoyesj	1288	41	temperature	temperature	NN
cord-000248-zueoyesj	1288	42	Kinetic	kinetic	JJ
cord-000248-zueoyesj	1288	43	partitioning	partitioning	NN
cord-000248-zueoyesj	1288	44	during	during	IN
cord-000248-zueoyesj	1288	45	folding	folding	NN
cord-000248-zueoyesj	1288	46	of	of	IN
cord-000248-zueoyesj	1288	47	the	the	DT
cord-000248-zueoyesj	1288	48	p53	p53	NN
cord-000248-zueoyesj	1288	49	DNA	dna	NN
cord-000248-zueoyesj	1288	50	binding	binding	NN
cord-000248-zueoyesj	1288	51	domain	domain	NN
cord-000248-zueoyesj	1288	52	p53	p53	NN
cord-000248-zueoyesj	1288	53	:	:	:
cord-000248-zueoyesj	1288	54	guardian	guardian	NN
cord-000248-zueoyesj	1288	55	of	of	IN
cord-000248-zueoyesj	1288	56	the	the	DT
cord-000248-zueoyesj	1288	57	genome	genome	NN
cord-000248-zueoyesj	1288	58	and	and	CC
cord-000248-zueoyesj	1288	59	policeman	policeman	NN
cord-000248-zueoyesj	1288	60	of	of	IN
cord-000248-zueoyesj	1288	61	the	the	DT
cord-000248-zueoyesj	1288	62	oncogenes	oncogene	NNS
cord-000248-zueoyesj	1288	63	in	in	IN
cord-000248-zueoyesj	1288	64	mitochondria	mitochondrion	NNS
cord-000248-zueoyesj	1288	65	enhances	enhance	VBZ
cord-000248-zueoyesj	1288	66	the	the	DT
cord-000248-zueoyesj	1288	67	accuracy	accuracy	NN
cord-000248-zueoyesj	1288	68	of	of	IN
cord-000248-zueoyesj	1288	69	DNA	dna	NN
cord-000248-zueoyesj	1288	70	synthesis	synthesis	NN
cord-000248-zueoyesj	1288	71	Structural	structural	JJ
cord-000248-zueoyesj	1288	72	biology	biology	NN
cord-000248-zueoyesj	1288	73	of	of	IN
cord-000248-zueoyesj	1288	74	the	the	DT
cord-000248-zueoyesj	1288	75	p53	p53	NN
cord-000248-zueoyesj	1288	76	tumour	tumour	NN
cord-000248-zueoyesj	1288	77	suppressor	suppressor	NN
cord-000248-zueoyesj	1288	78	Temperature	temperature	NN
cord-000248-zueoyesj	1288	79	sensitivity	sensitivity	NN
cord-000248-zueoyesj	1288	80	for	for	IN
cord-000248-zueoyesj	1288	81	conformation	conformation	NN
cord-000248-zueoyesj	1288	82	is	be	VBZ
cord-000248-zueoyesj	1288	83	an	an	DT
cord-000248-zueoyesj	1288	84	intrinsic	intrinsic	JJ
cord-000248-zueoyesj	1288	85	property	property	NN
cord-000248-zueoyesj	1288	86	of	of	IN
cord-000248-zueoyesj	1288	87	wild	wild	JJ
cord-000248-zueoyesj	1288	88	-	-	HYPH
cord-000248-zueoyesj	1288	89	type	type	NN
cord-000248-zueoyesj	1288	90	p53	p53	NN
cord-000248-zueoyesj	1288	91	Adaptive	adaptive	JJ
cord-000248-zueoyesj	1288	92	response	response	NN
cord-000248-zueoyesj	1288	93	of	of	IN
cord-000248-zueoyesj	1288	94	the	the	DT
cord-000248-zueoyesj	1288	95	skin	skin	NN
cord-000248-zueoyesj	1288	96	to	to	IN
cord-000248-zueoyesj	1288	97	UVB	uvb	NN
cord-000248-zueoyesj	1288	98	damage	damage	NN
cord-000248-zueoyesj	1288	99	:	:	:
cord-000248-zueoyesj	1288	100	role	role	NN
cord-000248-zueoyesj	1288	101	of	of	IN
cord-000248-zueoyesj	1288	102	the	the	DT
cord-000248-zueoyesj	1288	103	p53	p53	NN
cord-000248-zueoyesj	1288	104	protein	protein	NN
cord-000248-zueoyesj	1288	105	Tumorigenic	tumorigenic	JJ
cord-000248-zueoyesj	1288	106	conversion	conversion	NN
cord-000248-zueoyesj	1288	107	of	of	IN
cord-000248-zueoyesj	1288	108	immortal	immortal	JJ
cord-000248-zueoyesj	1288	109	human	human	JJ
cord-000248-zueoyesj	1288	110	skin	skin	NN
cord-000248-zueoyesj	1288	111	keratinocytes	keratinocyte	NNS
cord-000248-zueoyesj	1288	112	(	(	-LRB-
cord-000248-zueoyesj	1288	113	HaCaT	HaCaT	NNP
cord-000248-zueoyesj	1288	114	)	)	-RRB-
cord-000248-zueoyesj	1288	115	by	by	IN
cord-000248-zueoyesj	1288	116	elevated	elevated	JJ
cord-000248-zueoyesj	1288	117	temperature	temperature	NN
cord-000248-zueoyesj	1289	1	The	the	DT
cord-000248-zueoyesj	1289	2	story	story	NN
cord-000248-zueoyesj	1289	3	of	of	IN
cord-000248-zueoyesj	1289	4	the	the	DT
cord-000248-zueoyesj	1289	5	discovery	discovery	NN
cord-000248-zueoyesj	1289	6	of	of	IN
cord-000248-zueoyesj	1289	7	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1289	8	:	:	:
cord-000248-zueoyesj	1289	9	convergent	convergent	JJ
cord-000248-zueoyesj	1289	10	evolution	evolution	NN
cord-000248-zueoyesj	1289	11	of	of	IN
cord-000248-zueoyesj	1289	12	ideas	idea	NNS
cord-000248-zueoyesj	1289	13	-	-	:
cord-000248-zueoyesj	1289	14	but	but	CC
cord-000248-zueoyesj	1289	15	who	who	WP
cord-000248-zueoyesj	1289	16	got	get	VBD
cord-000248-zueoyesj	1289	17	there	there	RB
cord-000248-zueoyesj	1289	18	first	first	RB
cord-000248-zueoyesj	1289	19	?	?	.
cord-000248-zueoyesj	1290	1	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	1290	2	water	water	NN
cord-000248-zueoyesj	1290	3	channels	channel	NNS
cord-000248-zueoyesj	1290	4	:	:	:
cord-000248-zueoyesj	1291	1	molecular	molecular	JJ
cord-000248-zueoyesj	1291	2	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1291	3	for	for	IN
cord-000248-zueoyesj	1291	4	human	human	JJ
cord-000248-zueoyesj	1291	5	diseases	disease	NNS
cord-000248-zueoyesj	1292	1	The	the	DT
cord-000248-zueoyesj	1292	2	aquaporin	aquaporin	NN
cord-000248-zueoyesj	1292	3	family	family	NN
cord-000248-zueoyesj	1292	4	of	of	IN
cord-000248-zueoyesj	1292	5	water	water	NN
cord-000248-zueoyesj	1292	6	channels	channel	NNS
cord-000248-zueoyesj	1292	7	in	in	IN
cord-000248-zueoyesj	1292	8	kidney	kidney	NN
cord-000248-zueoyesj	1292	9	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	1292	10	CHIP	CHIP	NNP
cord-000248-zueoyesj	1292	11	:	:	:
cord-000248-zueoyesj	1292	12	the	the	DT
cord-000248-zueoyesj	1292	13	archetypal	archetypal	JJ
cord-000248-zueoyesj	1292	14	molecular	molecular	JJ
cord-000248-zueoyesj	1292	15	water	water	NN
cord-000248-zueoyesj	1292	16	channel	channel	NN
cord-000248-zueoyesj	1292	17	ABH	ABH	NNP
cord-000248-zueoyesj	1292	18	and	and	CC
cord-000248-zueoyesj	1292	19	Colton	Colton	NNP
cord-000248-zueoyesj	1292	20	blood	blood	NN
cord-000248-zueoyesj	1292	21	group	group	NN
cord-000248-zueoyesj	1292	22	antigens	antigen	NNS
cord-000248-zueoyesj	1292	23	on	on	IN
cord-000248-zueoyesj	1292	24	aquaporin-1	aquaporin-1	NNP
cord-000248-zueoyesj	1292	25	,	,	,
cord-000248-zueoyesj	1292	26	the	the	DT
cord-000248-zueoyesj	1292	27	human	human	JJ
cord-000248-zueoyesj	1292	28	red	red	JJ
cord-000248-zueoyesj	1292	29	cell	cell	NN
cord-000248-zueoyesj	1292	30	water	water	NN
cord-000248-zueoyesj	1292	31	channel	channel	NNP
cord-000248-zueoyesj	1292	32	protein	protein	NNP
cord-000248-zueoyesj	1292	33	Water	Water	NNP
cord-000248-zueoyesj	1292	34	channel	channel	NN
cord-000248-zueoyesj	1292	35	proteins	protein	NNS
cord-000248-zueoyesj	1292	36	:	:	:
cord-000248-zueoyesj	1292	37	from	from	IN
cord-000248-zueoyesj	1292	38	their	-PRON-	PRP$
cord-000248-zueoyesj	1292	39	discovery	discovery	NN
cord-000248-zueoyesj	1292	40	in	in	IN
cord-000248-zueoyesj	1292	41	1985	1985	CD
cord-000248-zueoyesj	1292	42	in	in	IN
cord-000248-zueoyesj	1292	43	Cluj	Cluj	NNP
cord-000248-zueoyesj	1292	44	-	-	HYPH
cord-000248-zueoyesj	1292	45	Napoca	Napoca	NNP
cord-000248-zueoyesj	1292	46	,	,	,
cord-000248-zueoyesj	1292	47	Romania	Romania	NNP
cord-000248-zueoyesj	1292	48	,	,	,
cord-000248-zueoyesj	1292	49	to	to	IN
cord-000248-zueoyesj	1292	50	the	the	DT
cord-000248-zueoyesj	1292	51	2003	2003	CD
cord-000248-zueoyesj	1292	52	Nobel	Nobel	NNP
cord-000248-zueoyesj	1292	53	Prize	Prize	NNP
cord-000248-zueoyesj	1292	54	in	in	IN
cord-000248-zueoyesj	1292	55	Chemistry	Chemistry	NNP
cord-000248-zueoyesj	1292	56	Structure	Structure	NNP
cord-000248-zueoyesj	1292	57	-	-	HYPH
cord-000248-zueoyesj	1292	58	function	function	NN
cord-000248-zueoyesj	1292	59	relationships	relationship	NNS
cord-000248-zueoyesj	1292	60	in	in	IN
cord-000248-zueoyesj	1292	61	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1292	62	A	a	DT
cord-000248-zueoyesj	1292	63	brief	brief	JJ
cord-000248-zueoyesj	1292	64	survey	survey	NN
cord-000248-zueoyesj	1292	65	of	of	IN
cord-000248-zueoyesj	1292	66	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1292	67	and	and	CC
cord-000248-zueoyesj	1292	68	their	-PRON-	PRP$
cord-000248-zueoyesj	1292	69	implications	implication	NNS
cord-000248-zueoyesj	1292	70	for	for	IN
cord-000248-zueoyesj	1292	71	renal	renal	JJ
cord-000248-zueoyesj	1292	72	physiology	physiology	NN
cord-000248-zueoyesj	1293	1	The	the	DT
cord-000248-zueoyesj	1293	2	structural	structural	JJ
cord-000248-zueoyesj	1293	3	basis	basis	NN
cord-000248-zueoyesj	1293	4	of	of	IN
cord-000248-zueoyesj	1293	5	water	water	NN
cord-000248-zueoyesj	1293	6	permeation	permeation	NN
cord-000248-zueoyesj	1293	7	and	and	CC
cord-000248-zueoyesj	1293	8	proton	proton	NN
cord-000248-zueoyesj	1293	9	exclusion	exclusion	NN
cord-000248-zueoyesj	1293	10	in	in	IN
cord-000248-zueoyesj	1293	11	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1293	12	Concerted	concerted	JJ
cord-000248-zueoyesj	1293	13	action	action	NN
cord-000248-zueoyesj	1293	14	of	of	IN
cord-000248-zueoyesj	1293	15	two	two	CD
cord-000248-zueoyesj	1293	16	cation	cation	NN
cord-000248-zueoyesj	1293	17	filters	filter	NNS
cord-000248-zueoyesj	1293	18	in	in	IN
cord-000248-zueoyesj	1293	19	the	the	DT
cord-000248-zueoyesj	1293	20	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1293	21	water	water	NNP
cord-000248-zueoyesj	1293	22	channel	channel	NNP
cord-000248-zueoyesj	1293	23	Knock	Knock	NNP
cord-000248-zueoyesj	1293	24	-	-	HYPH
cord-000248-zueoyesj	1293	25	out	out	RP
cord-000248-zueoyesj	1293	26	models	model	NNS
cord-000248-zueoyesj	1293	27	reveal	reveal	VBP
cord-000248-zueoyesj	1293	28	new	new	JJ
cord-000248-zueoyesj	1293	29	aquaporin	aquaporin	NN
cord-000248-zueoyesj	1293	30	functions	function	NNS
cord-000248-zueoyesj	1293	31	Involvement	Involvement	NNP
cord-000248-zueoyesj	1293	32	of	of	IN
cord-000248-zueoyesj	1293	33	aquaporin-5	aquaporin-5	NNP
cord-000248-zueoyesj	1293	34	in	in	IN
cord-000248-zueoyesj	1293	35	differentiation	differentiation	NN
cord-000248-zueoyesj	1293	36	of	of	IN
cord-000248-zueoyesj	1293	37	human	human	JJ
cord-000248-zueoyesj	1293	38	gastric	gastric	JJ
cord-000248-zueoyesj	1293	39	cancer	cancer	NN
cord-000248-zueoyesj	1293	40	cells	cell	NNS
cord-000248-zueoyesj	1293	41	Aquaporins	Aquaporins	NNP
cord-000248-zueoyesj	1293	42	-	-	HYPH
cord-000248-zueoyesj	1293	43	new	new	JJ
cord-000248-zueoyesj	1293	44	players	player	NNS
cord-000248-zueoyesj	1293	45	in	in	IN
cord-000248-zueoyesj	1293	46	cancer	cancer	NN
cord-000248-zueoyesj	1293	47	biology	biology	NN
cord-000248-zueoyesj	1293	48	Role	role	NN
cord-000248-zueoyesj	1293	49	of	of	IN
cord-000248-zueoyesj	1293	50	human	human	JJ
cord-000248-zueoyesj	1293	51	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1293	52	5	5	CD
cord-000248-zueoyesj	1293	53	in	in	IN
cord-000248-zueoyesj	1293	54	colorectal	colorectal	JJ
cord-000248-zueoyesj	1293	55	carcinogenesis	carcinogenesis	NN
cord-000248-zueoyesj	1293	56	Prevention	prevention	NN
cord-000248-zueoyesj	1293	57	of	of	IN
cord-000248-zueoyesj	1293	58	skin	skin	NN
cord-000248-zueoyesj	1293	59	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1293	60	and	and	CC
cord-000248-zueoyesj	1293	61	impairment	impairment	NN
cord-000248-zueoyesj	1293	62	of	of	IN
cord-000248-zueoyesj	1293	63	epidermal	epidermal	JJ
cord-000248-zueoyesj	1293	64	cell	cell	NN
cord-000248-zueoyesj	1293	65	proliferation	proliferation	NN
cord-000248-zueoyesj	1293	66	by	by	IN
cord-000248-zueoyesj	1293	67	targeted	target	VBN
cord-000248-zueoyesj	1293	68	aquaporin-3	aquaporin-3	NN
cord-000248-zueoyesj	1293	69	gene	gene	NN
cord-000248-zueoyesj	1293	70	disruption	disruption	NN
cord-000248-zueoyesj	1293	71	Aquaporin-3	Aquaporin-3	NNP
cord-000248-zueoyesj	1293	72	facilitates	facilitate	VBZ
cord-000248-zueoyesj	1293	73	epidermal	epidermal	JJ
cord-000248-zueoyesj	1293	74	cell	cell	NN
cord-000248-zueoyesj	1293	75	migration	migration	NN
cord-000248-zueoyesj	1293	76	and	and	CC
cord-000248-zueoyesj	1293	77	proliferation	proliferation	NN
cord-000248-zueoyesj	1293	78	during	during	IN
cord-000248-zueoyesj	1293	79	wound	wound	NN
cord-000248-zueoyesj	1293	80	healing	heal	VBG
cord-000248-zueoyesj	1293	81	Roles	role	NNS
cord-000248-zueoyesj	1293	82	of	of	IN
cord-000248-zueoyesj	1293	83	aquaporin-3	aquaporin-3	NNP
cord-000248-zueoyesj	1293	84	in	in	IN
cord-000248-zueoyesj	1293	85	the	the	DT
cord-000248-zueoyesj	1293	86	epidermis	epidermis	NN
cord-000248-zueoyesj	1293	87	Expression	expression	NN
cord-000248-zueoyesj	1293	88	profile	profile	NN
cord-000248-zueoyesj	1293	89	of	of	IN
cord-000248-zueoyesj	1293	90	early	early	JJ
cord-000248-zueoyesj	1293	91	lung	lung	NN
cord-000248-zueoyesj	1293	92	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1293	93	:	:	:
cord-000248-zueoyesj	1293	94	identification	identification	NN
cord-000248-zueoyesj	1293	95	of	of	IN
cord-000248-zueoyesj	1293	96	MRP3	MRP3	NNP
cord-000248-zueoyesj	1293	97	as	as	IN
cord-000248-zueoyesj	1293	98	a	a	DT
cord-000248-zueoyesj	1293	99	molecular	molecular	JJ
cord-000248-zueoyesj	1293	100	marker	marker	NN
cord-000248-zueoyesj	1293	101	for	for	IN
cord-000248-zueoyesj	1293	102	early	early	JJ
cord-000248-zueoyesj	1293	103	progression	progression	NN
cord-000248-zueoyesj	1293	104	Expression	expression	NN
cord-000248-zueoyesj	1293	105	of	of	IN
cord-000248-zueoyesj	1293	106	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1293	107	3	3	CD
cord-000248-zueoyesj	1293	108	in	in	IN
cord-000248-zueoyesj	1293	109	the	the	DT
cord-000248-zueoyesj	1293	110	human	human	JJ
cord-000248-zueoyesj	1293	111	prostate	prostate	NN
cord-000248-zueoyesj	1293	112	Expression	Expression	NNP
cord-000248-zueoyesj	1293	113	of	of	IN
cord-000248-zueoyesj	1293	114	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1293	115	3	3	CD
cord-000248-zueoyesj	1293	116	(	(	-LRB-
cord-000248-zueoyesj	1293	117	AQP3	AQP3	NNP
cord-000248-zueoyesj	1293	118	)	)	-RRB-
cord-000248-zueoyesj	1293	119	in	in	IN
cord-000248-zueoyesj	1293	120	normal	normal	JJ
cord-000248-zueoyesj	1293	121	and	and	CC
cord-000248-zueoyesj	1293	122	neoplastic	neoplastic	JJ
cord-000248-zueoyesj	1293	123	lung	lung	NN
cord-000248-zueoyesj	1293	124	tissues	tissue	NNS
cord-000248-zueoyesj	1293	125	Role	role	NN
cord-000248-zueoyesj	1293	126	of	of	IN
cord-000248-zueoyesj	1293	127	aquaporin-7	aquaporin-7	NNP
cord-000248-zueoyesj	1293	128	and	and	CC
cord-000248-zueoyesj	1293	129	aquaporin-9	aquaporin-9	VB
cord-000248-zueoyesj	1293	130	in	in	IN
cord-000248-zueoyesj	1293	131	glycerol	glycerol	NN
cord-000248-zueoyesj	1293	132	metabolism	metabolism	NN
cord-000248-zueoyesj	1294	1	Genetic	genetic	JJ
cord-000248-zueoyesj	1294	2	conservation	conservation	NN
cord-000248-zueoyesj	1294	3	of	of	IN
cord-000248-zueoyesj	1294	4	the	the	DT
cord-000248-zueoyesj	1294	5	GIL	GIL	NNP
cord-000248-zueoyesj	1294	6	blood	blood	NN
cord-000248-zueoyesj	1294	7	group	group	NN
cord-000248-zueoyesj	1294	8	determining	determine	VBG
cord-000248-zueoyesj	1294	9	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1294	10	3	3	CD
cord-000248-zueoyesj	1294	11	gene	gene	NN
cord-000248-zueoyesj	1294	12	in	in	IN
cord-000248-zueoyesj	1294	13	African	african	JJ
cord-000248-zueoyesj	1294	14	and	and	CC
cord-000248-zueoyesj	1294	15	Caucasian	caucasian	JJ
cord-000248-zueoyesj	1294	16	populations	population	NNS
cord-000248-zueoyesj	1294	17	Aquaporin	Aquaporin	NNP
cord-000248-zueoyesj	1294	18	9	9	CD
cord-000248-zueoyesj	1294	19	is	be	VBZ
cord-000248-zueoyesj	1294	20	the	the	DT
cord-000248-zueoyesj	1294	21	major	major	JJ
cord-000248-zueoyesj	1294	22	pathway	pathway	NN
cord-000248-zueoyesj	1294	23	for	for	IN
cord-000248-zueoyesj	1294	24	glycerol	glycerol	NN
cord-000248-zueoyesj	1294	25	uptake	uptake	NN
cord-000248-zueoyesj	1294	26	by	by	IN
cord-000248-zueoyesj	1294	27	mouse	mouse	NN
cord-000248-zueoyesj	1294	28	erythrocytes	erythrocyte	NNS
cord-000248-zueoyesj	1294	29	,	,	,
cord-000248-zueoyesj	1294	30	with	with	IN
cord-000248-zueoyesj	1294	31	implications	implication	NNS
cord-000248-zueoyesj	1294	32	for	for	IN
cord-000248-zueoyesj	1294	33	malarial	malarial	JJ
cord-000248-zueoyesj	1294	34	virulence	virulence	NN
cord-000248-zueoyesj	1294	35	pH	ph	NN
cord-000248-zueoyesj	1294	36	regulated	regulate	VBN
cord-000248-zueoyesj	1294	37	anion	anion	NN
cord-000248-zueoyesj	1294	38	permeability	permeability	NN
cord-000248-zueoyesj	1294	39	of	of	IN
cord-000248-zueoyesj	1294	40	aquaporin-6	aquaporin-6	NNP
cord-000248-zueoyesj	1295	1	Temporal	temporal	JJ
cord-000248-zueoyesj	1295	2	changes	change	NNS
cord-000248-zueoyesj	1295	3	in	in	IN
cord-000248-zueoyesj	1295	4	expression	expression	NN
cord-000248-zueoyesj	1295	5	of	of	IN
cord-000248-zueoyesj	1295	6	aquaporin3	aquaporin3	NN
cord-000248-zueoyesj	1295	7	,	,	,
cord-000248-zueoyesj	1296	1	-4	-4	NNP
cord-000248-zueoyesj	1296	2	,	,	,
cord-000248-zueoyesj	1296	3	-5	-5	NNP
cord-000248-zueoyesj	1296	4	and	and	CC
cord-000248-zueoyesj	1296	5	-8	-8	.
cord-000248-zueoyesj	1297	1	in	in	IN
cord-000248-zueoyesj	1297	2	rat	rat	NN
cord-000248-zueoyesj	1297	3	brains	brain	NNS
cord-000248-zueoyesj	1297	4	after	after	IN
cord-000248-zueoyesj	1297	5	permanent	permanent	JJ
cord-000248-zueoyesj	1297	6	focal	focal	JJ
cord-000248-zueoyesj	1297	7	cerebral	cerebral	JJ
cord-000248-zueoyesj	1297	8	ischemia	ischemia	NN
cord-000248-zueoyesj	1297	9	Expression	expression	NN
cord-000248-zueoyesj	1297	10	of	of	IN
cord-000248-zueoyesj	1297	11	renal	renal	JJ
cord-000248-zueoyesj	1297	12	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1298	1	is	be	VBZ
cord-000248-zueoyesj	1298	2	down	down	RB
cord-000248-zueoyesj	1298	3	-	-	HYPH
cord-000248-zueoyesj	1298	4	regulated	regulate	VBN
cord-000248-zueoyesj	1298	5	in	in	IN
cord-000248-zueoyesj	1298	6	children	child	NNS
cord-000248-zueoyesj	1298	7	with	with	IN
cord-000248-zueoyesj	1298	8	congenital	congenital	JJ
cord-000248-zueoyesj	1298	9	hydronephrosis	hydronephrosis	NN
cord-000248-zueoyesj	1298	10	Aquaporins	Aquaporins	NNP
cord-000248-zueoyesj	1298	11	as	as	IN
cord-000248-zueoyesj	1298	12	potential	potential	JJ
cord-000248-zueoyesj	1298	13	drug	drug	NN
cord-000248-zueoyesj	1298	14	targets	target	NNS
cord-000248-zueoyesj	1298	15	for	for	IN
cord-000248-zueoyesj	1298	16	Meniere	Meniere	NNP
cord-000248-zueoyesj	1298	17	's	's	POS
cord-000248-zueoyesj	1298	18	disease	disease	NN
cord-000248-zueoyesj	1298	19	and	and	CC
cord-000248-zueoyesj	1298	20	its	-PRON-	PRP$
cord-000248-zueoyesj	1298	21	related	related	JJ
cord-000248-zueoyesj	1298	22	diseases	disease	NNS
cord-000248-zueoyesj	1298	23	In	in	IN
cord-000248-zueoyesj	1298	24	situ	situ	NN
cord-000248-zueoyesj	1298	25	fluorescence	fluorescence	NN
cord-000248-zueoyesj	1298	26	measurement	measurement	NN
cord-000248-zueoyesj	1298	27	of	of	IN
cord-000248-zueoyesj	1298	28	tear	tear	JJ
cord-000248-zueoyesj	1298	29	film	film	NN
cord-000248-zueoyesj	1298	30	[	[	-LRB-
cord-000248-zueoyesj	1298	31	Na+	na+	NN
cord-000248-zueoyesj	1298	32	]	]	-RRB-
cord-000248-zueoyesj	1298	33	,	,	,
cord-000248-zueoyesj	1298	34	[	[	-LRB-
cord-000248-zueoyesj	1298	35	K+	K+	NNP
cord-000248-zueoyesj	1298	36	]	]	-RRB-
cord-000248-zueoyesj	1298	37	,	,	,
cord-000248-zueoyesj	1298	38	[	[	-LRB-
cord-000248-zueoyesj	1298	39	Cl2	Cl2	NNP
cord-000248-zueoyesj	1298	40	]	]	-RRB-
cord-000248-zueoyesj	1298	41	,	,	,
cord-000248-zueoyesj	1298	42	and	and	CC
cord-000248-zueoyesj	1298	43	pH	ph	NN
cord-000248-zueoyesj	1298	44	in	in	IN
cord-000248-zueoyesj	1298	45	mice	mouse	NNS
cord-000248-zueoyesj	1299	1	shows	show	NNS
cord-000248-zueoyesj	1299	2	marked	mark	VBD
cord-000248-zueoyesj	1299	3	hypertonicity	hypertonicity	NN
cord-000248-zueoyesj	1299	4	in	in	IN
cord-000248-zueoyesj	1299	5	aquaporin-5	aquaporin-5	NNP
cord-000248-zueoyesj	1299	6	deficiency	deficiency	NN
cord-000248-zueoyesj	1299	7	Regulation	regulation	NN
cord-000248-zueoyesj	1299	8	of	of	IN
cord-000248-zueoyesj	1299	9	aquaporin-2	aquaporin-2	NNP
cord-000248-zueoyesj	1299	10	trafficking	traffic	VBG
cord-000248-zueoyesj	1299	11	The	the	DT
cord-000248-zueoyesj	1299	12	role	role	NN
cord-000248-zueoyesj	1299	13	of	of	IN
cord-000248-zueoyesj	1299	14	water	water	NN
cord-000248-zueoyesj	1299	15	channel	channel	NNP
cord-000248-zueoyesj	1299	16	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1299	17	3	3	CD
cord-000248-zueoyesj	1299	18	in	in	IN
cord-000248-zueoyesj	1299	19	the	the	DT
cord-000248-zueoyesj	1299	20	mechanism	mechanism	NN
cord-000248-zueoyesj	1299	21	of	of	IN
cord-000248-zueoyesj	1299	22	TNF	TNF	NNP
cord-000248-zueoyesj	1299	23	-	-	HYPH
cord-000248-zueoyesj	1299	24	alphamediated	alphamediate	VBN
cord-000248-zueoyesj	1299	25	proinflammatory	proinflammatory	JJ
cord-000248-zueoyesj	1299	26	events	event	NNS
cord-000248-zueoyesj	1299	27	:	:	:
cord-000248-zueoyesj	1299	28	Implication	implication	NN
cord-000248-zueoyesj	1299	29	in	in	IN
cord-000248-zueoyesj	1299	30	periodontal	periodontal	JJ
cord-000248-zueoyesj	1299	31	inflammation	inflammation	NN
cord-000248-zueoyesj	1300	1	Nephrogenic	nephrogenic	JJ
cord-000248-zueoyesj	1300	2	diabetes	diabete	VBZ
cord-000248-zueoyesj	1300	3	insipidus	insipidus	NN
cord-000248-zueoyesj	1300	4	in	in	IN
cord-000248-zueoyesj	1300	5	mice	mouse	NNS
cord-000248-zueoyesj	1300	6	lacking	lack	VBG
cord-000248-zueoyesj	1300	7	aquaporin-3	aquaporin-3	NN
cord-000248-zueoyesj	1300	8	water	water	NN
cord-000248-zueoyesj	1300	9	channels	channel	NNS
cord-000248-zueoyesj	1301	1	The	the	DT
cord-000248-zueoyesj	1301	2	role	role	NN
cord-000248-zueoyesj	1301	3	of	of	IN
cord-000248-zueoyesj	1301	4	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1301	5	in	in	IN
cord-000248-zueoyesj	1301	6	dendritic	dendritic	JJ
cord-000248-zueoyesj	1301	7	cell	cell	NN
cord-000248-zueoyesj	1301	8	macropinocytosis	macropinocytosis	NNP
cord-000248-zueoyesj	1301	9	Structure	Structure	NNP
cord-000248-zueoyesj	1301	10	and	and	CC
cord-000248-zueoyesj	1301	11	function	function	NN
cord-000248-zueoyesj	1301	12	of	of	IN
cord-000248-zueoyesj	1301	13	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1301	14	water	water	NN
cord-000248-zueoyesj	1301	15	channels	channel	NNS
cord-000248-zueoyesj	1301	16	Selection	Selection	NNP
cord-000248-zueoyesj	1301	17	of	of	IN
cord-000248-zueoyesj	1301	18	Discriminative	Discriminative	NNP
cord-000248-zueoyesj	1301	19	Genes	Genes	NNPS
cord-000248-zueoyesj	1301	20	in	in	IN
cord-000248-zueoyesj	1301	21	Microarray	Microarray	NNP
cord-000248-zueoyesj	1301	22	Experiments	experiment	NNS
cord-000248-zueoyesj	1301	23	using	use	VBG
cord-000248-zueoyesj	1301	24	Mathematical	Mathematical	NNP
cord-000248-zueoyesj	1301	25	Programming	Programming	NNP
cord-000248-zueoyesj	1301	26	Inhibition	Inhibition	NNP
cord-000248-zueoyesj	1301	27	of	of	IN
cord-000248-zueoyesj	1301	28	the	the	DT
cord-000248-zueoyesj	1301	29	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1301	30	3	3	CD
cord-000248-zueoyesj	1301	31	water	water	NN
cord-000248-zueoyesj	1301	32	channel	channel	NN
cord-000248-zueoyesj	1301	33	increases	increase	VBZ
cord-000248-zueoyesj	1301	34	the	the	DT
cord-000248-zueoyesj	1301	35	sensitivity	sensitivity	NN
cord-000248-zueoyesj	1301	36	of	of	IN
cord-000248-zueoyesj	1301	37	prostate	prostate	NN
cord-000248-zueoyesj	1301	38	cancer	cancer	NN
cord-000248-zueoyesj	1301	39	cells	cell	NNS
cord-000248-zueoyesj	1301	40	to	to	IN
cord-000248-zueoyesj	1301	41	cryotherapy	cryotherapy	NN
cord-000248-zueoyesj	1301	42	Point	point	NN
cord-000248-zueoyesj	1301	43	mutations	mutation	NNS
cord-000248-zueoyesj	1301	44	in	in	IN
cord-000248-zueoyesj	1301	45	the	the	DT
cord-000248-zueoyesj	1301	46	aromatic	aromatic	JJ
cord-000248-zueoyesj	1301	47	/	/	SYM
cord-000248-zueoyesj	1301	48	arginine	arginine	NN
cord-000248-zueoyesj	1301	49	region	region	NN
cord-000248-zueoyesj	1301	50	in	in	IN
cord-000248-zueoyesj	1301	51	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1301	52	1	1	CD
cord-000248-zueoyesj	1301	53	allow	allow	VBP
cord-000248-zueoyesj	1301	54	passage	passage	NN
cord-000248-zueoyesj	1301	55	of	of	IN
cord-000248-zueoyesj	1301	56	urea	urea	NN
cord-000248-zueoyesj	1301	57	,	,	,
cord-000248-zueoyesj	1301	58	glycerol	glycerol	NN
cord-000248-zueoyesj	1301	59	,	,	,
cord-000248-zueoyesj	1301	60	ammonia	ammonia	NN
cord-000248-zueoyesj	1301	61	,	,	,
cord-000248-zueoyesj	1301	62	and	and	CC
cord-000248-zueoyesj	1301	63	protons	proton	NNS
cord-000248-zueoyesj	1301	64	Mechanism	Mechanism	NNP
cord-000248-zueoyesj	1301	65	of	of	IN
cord-000248-zueoyesj	1301	66	aquaporin-4	aquaporin-4	NNP
cord-000248-zueoyesj	1301	67	's	's	POS
cord-000248-zueoyesj	1301	68	fast	fast	JJ
cord-000248-zueoyesj	1301	69	and	and	CC
cord-000248-zueoyesj	1301	70	highly	highly	RB
cord-000248-zueoyesj	1301	71	selective	selective	JJ
cord-000248-zueoyesj	1301	72	water	water	NN
cord-000248-zueoyesj	1301	73	conduction	conduction	NN
cord-000248-zueoyesj	1301	74	and	and	CC
cord-000248-zueoyesj	1301	75	proton	proton	NN
cord-000248-zueoyesj	1301	76	exclusion	exclusion	NN
cord-000248-zueoyesj	1301	77	Dynamics	dynamic	NNS
cord-000248-zueoyesj	1301	78	and	and	CC
cord-000248-zueoyesj	1301	79	energetics	energetic	NNS
cord-000248-zueoyesj	1301	80	of	of	IN
cord-000248-zueoyesj	1301	81	permeation	permeation	NN
cord-000248-zueoyesj	1301	82	through	through	IN
cord-000248-zueoyesj	1301	83	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1301	84	.	.	.
cord-000248-zueoyesj	1302	1	What	what	WP
cord-000248-zueoyesj	1302	2	do	do	VBP
cord-000248-zueoyesj	1302	3	we	-PRON-	PRP
cord-000248-zueoyesj	1302	4	learn	learn	VB
cord-000248-zueoyesj	1302	5	from	from	IN
cord-000248-zueoyesj	1302	6	molecular	molecular	JJ
cord-000248-zueoyesj	1302	7	dynamics	dynamic	NNS
cord-000248-zueoyesj	1302	8	simulations	simulation	NNS
cord-000248-zueoyesj	1302	9	?	?	.
cord-000248-zueoyesj	1303	1	In	in	IN
cord-000248-zueoyesj	1303	2	vitro	vitro	FW
cord-000248-zueoyesj	1303	3	analysis	analysis	NN
cord-000248-zueoyesj	1303	4	and	and	CC
cord-000248-zueoyesj	1303	5	modification	modification	NN
cord-000248-zueoyesj	1303	6	of	of	IN
cord-000248-zueoyesj	1303	7	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1303	8	pore	pore	NN
cord-000248-zueoyesj	1303	9	selectivity	selectivity	NN
cord-000248-zueoyesj	1303	10	Structure	Structure	NNP
cord-000248-zueoyesj	1303	11	-	-	HYPH
cord-000248-zueoyesj	1303	12	function	function	NN
cord-000248-zueoyesj	1303	13	analysis	analysis	NN
cord-000248-zueoyesj	1303	14	of	of	IN
cord-000248-zueoyesj	1303	15	plant	plant	NN
cord-000248-zueoyesj	1303	16	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1304	1	AtPIP2;1	atpip2;1	IN
cord-000248-zueoyesj	1304	2	gating	gate	VBG
cord-000248-zueoyesj	1304	3	by	by	IN
cord-000248-zueoyesj	1304	4	divalent	divalent	JJ
cord-000248-zueoyesj	1304	5	cations	cation	NNS
cord-000248-zueoyesj	1304	6	and	and	CC
cord-000248-zueoyesj	1304	7	protons	proton	NNS
cord-000248-zueoyesj	1304	8	Ion	ion	NN
cord-000248-zueoyesj	1304	9	exclusion	exclusion	NN
cord-000248-zueoyesj	1304	10	mechanism	mechanism	NN
cord-000248-zueoyesj	1304	11	in	in	IN
cord-000248-zueoyesj	1304	12	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1304	13	at	at	IN
cord-000248-zueoyesj	1304	14	an	an	DT
cord-000248-zueoyesj	1304	15	atomistic	atomistic	JJ
cord-000248-zueoyesj	1304	16	level	level	NN
cord-000248-zueoyesj	1304	17	Aquaporins	Aquaporins	NNP
cord-000248-zueoyesj	1304	18	with	with	IN
cord-000248-zueoyesj	1304	19	selectivity	selectivity	NN
cord-000248-zueoyesj	1304	20	for	for	IN
cord-000248-zueoyesj	1304	21	unconventional	unconventional	JJ
cord-000248-zueoyesj	1304	22	permeants	permeant	NNS
cord-000248-zueoyesj	1304	23	Molecular	Molecular	NNP
cord-000248-zueoyesj	1304	24	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1304	25	of	of	IN
cord-000248-zueoyesj	1304	26	conduction	conduction	NN
cord-000248-zueoyesj	1304	27	and	and	CC
cord-000248-zueoyesj	1304	28	selectivity	selectivity	NN
cord-000248-zueoyesj	1304	29	in	in	IN
cord-000248-zueoyesj	1304	30	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1304	31	water	water	NN
cord-000248-zueoyesj	1304	32	channels	channel	NNS
cord-000248-zueoyesj	1305	1	Fast	fast	JJ
cord-000248-zueoyesj	1305	2	and	and	CC
cord-000248-zueoyesj	1305	3	selective	selective	JJ
cord-000248-zueoyesj	1305	4	ammonia	ammonia	NN
cord-000248-zueoyesj	1305	5	transport	transport	NN
cord-000248-zueoyesj	1305	6	by	by	IN
cord-000248-zueoyesj	1305	7	aquaporin-8	aquaporin-8	NNP
cord-000248-zueoyesj	1306	1	The	the	DT
cord-000248-zueoyesj	1306	2	high	high	JJ
cord-000248-zueoyesj	1306	3	diversity	diversity	NN
cord-000248-zueoyesj	1306	4	and	and	CC
cord-000248-zueoyesj	1306	5	regulation	regulation	NN
cord-000248-zueoyesj	1306	6	of	of	IN
cord-000248-zueoyesj	1306	7	plant	plant	NN
cord-000248-zueoyesj	1306	8	water	water	NN
cord-000248-zueoyesj	1306	9	channels	channel	NNS
cord-000248-zueoyesj	1306	10	Charge	charge	VBP
cord-000248-zueoyesj	1306	11	delocalization	delocalization	NN
cord-000248-zueoyesj	1306	12	in	in	IN
cord-000248-zueoyesj	1306	13	proton	proton	NN
cord-000248-zueoyesj	1306	14	channels	channel	NNS
cord-000248-zueoyesj	1306	15	,	,	,
cord-000248-zueoyesj	1306	16	I	-PRON-	PRP
cord-000248-zueoyesj	1306	17	:	:	:
cord-000248-zueoyesj	1306	18	the	the	DT
cord-000248-zueoyesj	1306	19	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1306	20	channels	channel	NNS
cord-000248-zueoyesj	1306	21	and	and	CC
cord-000248-zueoyesj	1306	22	proton	proton	NN
cord-000248-zueoyesj	1306	23	blockage	blockage	NN
cord-000248-zueoyesj	1306	24	Regulation	regulation	NN
cord-000248-zueoyesj	1306	25	of	of	IN
cord-000248-zueoyesj	1306	26	selectivity	selectivity	NN
cord-000248-zueoyesj	1306	27	and	and	CC
cord-000248-zueoyesj	1306	28	translocation	translocation	NN
cord-000248-zueoyesj	1306	29	of	of	IN
cord-000248-zueoyesj	1306	30	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1306	31	:	:	:
cord-000248-zueoyesj	1306	32	an	an	DT
cord-000248-zueoyesj	1306	33	update	update	NN
cord-000248-zueoyesj	1306	34	Toward	toward	IN
cord-000248-zueoyesj	1306	35	theoretical	theoretical	JJ
cord-000248-zueoyesj	1306	36	analysis	analysis	NN
cord-000248-zueoyesj	1306	37	of	of	IN
cord-000248-zueoyesj	1306	38	long	long	JJ
cord-000248-zueoyesj	1306	39	-	-	HYPH
cord-000248-zueoyesj	1306	40	range	range	NN
cord-000248-zueoyesj	1306	41	proton	proton	NN
cord-000248-zueoyesj	1306	42	transfer	transfer	NN
cord-000248-zueoyesj	1306	43	kinetics	kinetic	NNS
cord-000248-zueoyesj	1306	44	in	in	IN
cord-000248-zueoyesj	1306	45	biomolecular	biomolecular	JJ
cord-000248-zueoyesj	1306	46	pumps	pump	NNS
cord-000248-zueoyesj	1306	47	The	the	DT
cord-000248-zueoyesj	1306	48	barrier	barrier	NN
cord-000248-zueoyesj	1306	49	for	for	IN
cord-000248-zueoyesj	1306	50	proton	proton	NN
cord-000248-zueoyesj	1306	51	transport	transport	NN
cord-000248-zueoyesj	1306	52	in	in	IN
cord-000248-zueoyesj	1306	53	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1306	54	as	as	IN
cord-000248-zueoyesj	1306	55	a	a	DT
cord-000248-zueoyesj	1306	56	challenge	challenge	NN
cord-000248-zueoyesj	1306	57	for	for	IN
cord-000248-zueoyesj	1306	58	electrostatic	electrostatic	JJ
cord-000248-zueoyesj	1306	59	models	model	NNS
cord-000248-zueoyesj	1306	60	:	:	:
cord-000248-zueoyesj	1307	1	the	the	DT
cord-000248-zueoyesj	1307	2	role	role	NN
cord-000248-zueoyesj	1307	3	of	of	IN
cord-000248-zueoyesj	1307	4	protein	protein	NN
cord-000248-zueoyesj	1307	5	relaxation	relaxation	NN
cord-000248-zueoyesj	1307	6	in	in	IN
cord-000248-zueoyesj	1307	7	mutational	mutational	JJ
cord-000248-zueoyesj	1307	8	calculations	calculation	NNS
cord-000248-zueoyesj	1308	1	The	the	DT
cord-000248-zueoyesj	1308	2	mechanism	mechanism	NN
cord-000248-zueoyesj	1308	3	of	of	IN
cord-000248-zueoyesj	1308	4	proton	proton	NN
cord-000248-zueoyesj	1308	5	exclusion	exclusion	NN
cord-000248-zueoyesj	1308	6	in	in	IN
cord-000248-zueoyesj	1308	7	the	the	DT
cord-000248-zueoyesj	1308	8	aquaporin-1	aquaporin-1	NNP
cord-000248-zueoyesj	1308	9	water	water	NN
cord-000248-zueoyesj	1308	10	channel	channel	NN
cord-000248-zueoyesj	1309	1	What	what	WP
cord-000248-zueoyesj	1309	2	really	really	RB
cord-000248-zueoyesj	1309	3	prevents	prevent	VBZ
cord-000248-zueoyesj	1309	4	proton	proton	NN
cord-000248-zueoyesj	1309	5	transport	transport	NN
cord-000248-zueoyesj	1309	6	through	through	IN
cord-000248-zueoyesj	1309	7	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1309	8	?	?	.
cord-000248-zueoyesj	1310	1	Charge	charge	NN
cord-000248-zueoyesj	1310	2	self	self	NN
cord-000248-zueoyesj	1310	3	-	-	HYPH
cord-000248-zueoyesj	1310	4	energy	energy	NN
cord-000248-zueoyesj	1310	5	versus	versus	IN
cord-000248-zueoyesj	1310	6	proton	proton	NN
cord-000248-zueoyesj	1310	7	wire	wire	NN
cord-000248-zueoyesj	1310	8	proposals	proposal	NNS
cord-000248-zueoyesj	1310	9	Control	Control	NNP
cord-000248-zueoyesj	1310	10	of	of	IN
cord-000248-zueoyesj	1310	11	the	the	DT
cord-000248-zueoyesj	1310	12	selectivity	selectivity	NN
cord-000248-zueoyesj	1310	13	of	of	IN
cord-000248-zueoyesj	1310	14	the	the	DT
cord-000248-zueoyesj	1310	15	aquaporin	aquaporin	NNP
cord-000248-zueoyesj	1310	16	water	water	NNP
cord-000248-zueoyesj	1310	17	channel	channel	NNP
cord-000248-zueoyesj	1310	18	family	family	NN
cord-000248-zueoyesj	1310	19	by	by	IN
cord-000248-zueoyesj	1310	20	global	global	JJ
cord-000248-zueoyesj	1310	21	orientational	orientational	JJ
cord-000248-zueoyesj	1310	22	tuning	tuning	NN
cord-000248-zueoyesj	1310	23	The	the	DT
cord-000248-zueoyesj	1310	24	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1311	1	Aquaporin-1	Aquaporin-1	NNP
cord-000248-zueoyesj	1311	2	and	and	CC
cord-000248-zueoyesj	1311	3	HCO3(-)-Cl	HCO3(-)-Cl	NNP
cord-000248-zueoyesj	1311	4	-	-	HYPH
cord-000248-zueoyesj	1311	5	transportermediated	transportermediated	JJ
cord-000248-zueoyesj	1311	6	transport	transport	NN
cord-000248-zueoyesj	1311	7	of	of	IN
cord-000248-zueoyesj	1311	8	CO2	co2	NN
cord-000248-zueoyesj	1311	9	across	across	IN
cord-000248-zueoyesj	1311	10	the	the	DT
cord-000248-zueoyesj	1311	11	human	human	JJ
cord-000248-zueoyesj	1311	12	erythrocyte	erythrocyte	NN
cord-000248-zueoyesj	1311	13	membrane	membrane	NN
cord-000248-zueoyesj	1311	14	Ammonia	ammonia	NN
cord-000248-zueoyesj	1311	15	and	and	CC
cord-000248-zueoyesj	1311	16	urea	urea	NN
cord-000248-zueoyesj	1311	17	permeability	permeability	NN
cord-000248-zueoyesj	1311	18	of	of	IN
cord-000248-zueoyesj	1311	19	mammalian	mammalian	JJ
cord-000248-zueoyesj	1311	20	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1311	21	Expression	Expression	NNP
cord-000248-zueoyesj	1311	22	and	and	CC
cord-000248-zueoyesj	1311	23	function	function	NN
cord-000248-zueoyesj	1311	24	of	of	IN
cord-000248-zueoyesj	1311	25	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1311	26	in	in	IN
cord-000248-zueoyesj	1311	27	human	human	JJ
cord-000248-zueoyesj	1311	28	skin	skin	NN
cord-000248-zueoyesj	1311	29	:	:	:
cord-000248-zueoyesj	1312	1	Is	be	VBZ
cord-000248-zueoyesj	1312	2	aquaporin-3	aquaporin-3	NN
cord-000248-zueoyesj	1312	3	just	just	RB
cord-000248-zueoyesj	1312	4	a	a	DT
cord-000248-zueoyesj	1312	5	glycerol	glycerol	NN
cord-000248-zueoyesj	1312	6	transporter	transporter	NN
cord-000248-zueoyesj	1312	7	Physiological	physiological	JJ
cord-000248-zueoyesj	1312	8	roles	role	NNS
cord-000248-zueoyesj	1312	9	of	of	IN
cord-000248-zueoyesj	1312	10	glyceroltransporting	glyceroltransporte	VBG
cord-000248-zueoyesj	1312	11	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1312	12	:	:	:
cord-000248-zueoyesj	1312	13	the	the	DT
cord-000248-zueoyesj	1312	14	aquaglyceroporins	aquaglyceroporin	NNS
cord-000248-zueoyesj	1312	15	A	a	DT
cord-000248-zueoyesj	1312	16	role	role	NN
cord-000248-zueoyesj	1312	17	for	for	IN
cord-000248-zueoyesj	1312	18	mitochondrial	mitochondrial	JJ
cord-000248-zueoyesj	1312	19	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1312	20	in	in	IN
cord-000248-zueoyesj	1312	21	cellular	cellular	JJ
cord-000248-zueoyesj	1312	22	life	life	NN
cord-000248-zueoyesj	1312	23	-	-	HYPH
cord-000248-zueoyesj	1312	24	and	and	CC
cord-000248-zueoyesj	1312	25	-	-	HYPH
cord-000248-zueoyesj	1312	26	death	death	NN
cord-000248-zueoyesj	1312	27	decisions	decision	NNS
cord-000248-zueoyesj	1312	28	?	?	.
cord-000248-zueoyesj	1313	1	Functional	functional	JJ
cord-000248-zueoyesj	1313	2	expression	expression	NN
cord-000248-zueoyesj	1313	3	of	of	IN
cord-000248-zueoyesj	1313	4	AQP3	AQP3	NNP
cord-000248-zueoyesj	1313	5	in	in	IN
cord-000248-zueoyesj	1313	6	human	human	JJ
cord-000248-zueoyesj	1313	7	skin	skin	NN
cord-000248-zueoyesj	1313	8	epidermis	epidermis	NN
cord-000248-zueoyesj	1313	9	and	and	CC
cord-000248-zueoyesj	1313	10	reconstructed	reconstructed	JJ
cord-000248-zueoyesj	1313	11	epidermis	epidermis	NN
cord-000248-zueoyesj	1313	12	Skin	skin	NN
cord-000248-zueoyesj	1313	13	hydration	hydration	NN
cord-000248-zueoyesj	1313	14	:	:	:
cord-000248-zueoyesj	1313	15	a	a	DT
cord-000248-zueoyesj	1313	16	review	review	NN
cord-000248-zueoyesj	1313	17	on	on	IN
cord-000248-zueoyesj	1313	18	its	-PRON-	PRP$
cord-000248-zueoyesj	1313	19	molecular	molecular	JJ
cord-000248-zueoyesj	1313	20	mechanisms	mechanism	NNS
cord-000248-zueoyesj	1313	21	Hydrating	hydrate	VBG
cord-000248-zueoyesj	1313	22	skin	skin	NN
cord-000248-zueoyesj	1313	23	by	by	IN
cord-000248-zueoyesj	1313	24	stimulating	stimulate	VBG
cord-000248-zueoyesj	1313	25	biosynthesis	biosynthesis	NN
cord-000248-zueoyesj	1313	26	of	of	IN
cord-000248-zueoyesj	1313	27	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1313	28	Pores	pore	NNS
cord-000248-zueoyesj	1313	29	in	in	IN
cord-000248-zueoyesj	1313	30	the	the	DT
cord-000248-zueoyesj	1313	31	epidermis	epidermis	NN
cord-000248-zueoyesj	1313	32	:	:	:
cord-000248-zueoyesj	1313	33	aquaporins	aquaporin	NNS
cord-000248-zueoyesj	1313	34	and	and	CC
cord-000248-zueoyesj	1313	35	tight	tight	JJ
cord-000248-zueoyesj	1313	36	junctions	junction	NNS
cord-000248-zueoyesj	1313	37	Biophysical	biophysical	JJ
cord-000248-zueoyesj	1313	38	properties	property	NNS
cord-000248-zueoyesj	1313	39	of	of	IN
cord-000248-zueoyesj	1313	40	epithelial	epithelial	JJ
cord-000248-zueoyesj	1313	41	water	water	NN
cord-000248-zueoyesj	1313	42	channels	channel	NNS
cord-000248-zueoyesj	1314	1	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1314	2	localization	localization	NN
cord-000248-zueoyesj	1314	3	to	to	IN
cord-000248-zueoyesj	1314	4	the	the	DT
cord-000248-zueoyesj	1314	5	telomere	telomere	NN
cord-000248-zueoyesj	1314	6	and	and	CC
cord-000248-zueoyesj	1314	7	its	-PRON-	PRP$
cord-000248-zueoyesj	1314	8	loss	loss	NN
cord-000248-zueoyesj	1314	9	from	from	IN
cord-000248-zueoyesj	1314	10	the	the	DT
cord-000248-zueoyesj	1314	11	telomere	telomere	NN
cord-000248-zueoyesj	1314	12	in	in	IN
cord-000248-zueoyesj	1314	13	response	response	NN
cord-000248-zueoyesj	1314	14	to	to	IN
cord-000248-zueoyesj	1314	15	DNA	dna	NN
cord-000248-zueoyesj	1314	16	damage	damage	NN
cord-000248-zueoyesj	1314	17	Disruption	disruption	NN
cord-000248-zueoyesj	1314	18	of	of	IN
cord-000248-zueoyesj	1314	19	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1314	20	function	function	NN
cord-000248-zueoyesj	1314	21	results	result	NNS
cord-000248-zueoyesj	1314	22	in	in	IN
cord-000248-zueoyesj	1314	23	telomere	telomere	NN
cord-000248-zueoyesj	1314	24	lengthening	lengthening	NN
cord-000248-zueoyesj	1314	25	and	and	CC
cord-000248-zueoyesj	1314	26	increased	increase	VBN
cord-000248-zueoyesj	1314	27	anaphase	anaphase	NN
cord-000248-zueoyesj	1314	28	bridge	bridge	NN
cord-000248-zueoyesj	1314	29	formation	formation	NN
cord-000248-zueoyesj	1314	30	in	in	IN
cord-000248-zueoyesj	1314	31	immortalized	immortalize	VBN
cord-000248-zueoyesj	1314	32	cell	cell	NN
cord-000248-zueoyesj	1314	33	lines	line	NNS
cord-000248-zueoyesj	1315	1	The	the	DT
cord-000248-zueoyesj	1315	2	role	role	NN
cord-000248-zueoyesj	1315	3	of	of	IN
cord-000248-zueoyesj	1315	4	DNA	dna	NN
cord-000248-zueoyesj	1315	5	damage	damage	NN
cord-000248-zueoyesj	1315	6	response	response	NN
cord-000248-zueoyesj	1315	7	proteins	protein	NNS
cord-000248-zueoyesj	1315	8	at	at	IN
cord-000248-zueoyesj	1315	9	telomeresan	telomeresan	NNP
cord-000248-zueoyesj	1315	10	'	'	''
cord-000248-zueoyesj	1315	11	'	'	``
cord-000248-zueoyesj	1315	12	integrative	integrative	JJ
cord-000248-zueoyesj	1315	13	'	'	''
cord-000248-zueoyesj	1315	14	'	'	''
cord-000248-zueoyesj	1315	15	model	model	NN
cord-000248-zueoyesj	1315	16	Correlating	correlate	VBG
cord-000248-zueoyesj	1315	17	breakage	breakage	NN
cord-000248-zueoyesj	1315	18	-	-	HYPH
cord-000248-zueoyesj	1315	19	fusion	fusion	NN
cord-000248-zueoyesj	1315	20	-	-	HYPH
cord-000248-zueoyesj	1315	21	bridge	bridge	NN
cord-000248-zueoyesj	1315	22	events	event	NNS
cord-000248-zueoyesj	1315	23	with	with	IN
cord-000248-zueoyesj	1315	24	the	the	DT
cord-000248-zueoyesj	1315	25	overall	overall	JJ
cord-000248-zueoyesj	1315	26	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1315	27	instability	instability	NN
cord-000248-zueoyesj	1315	28	and	and	CC
cord-000248-zueoyesj	1315	29	in	in	IN
cord-000248-zueoyesj	1315	30	vitro	vitro	FW
cord-000248-zueoyesj	1315	31	karyotype	karyotype	NN
cord-000248-zueoyesj	1315	32	evolution	evolution	NN
cord-000248-zueoyesj	1315	33	in	in	IN
cord-000248-zueoyesj	1315	34	prostate	prostate	NN
cord-000248-zueoyesj	1315	35	cancer	cancer	NN
cord-000248-zueoyesj	1315	36	Telomere	telomere	NN
cord-000248-zueoyesj	1315	37	shortening	shortening	NN
cord-000248-zueoyesj	1315	38	is	be	VBZ
cord-000248-zueoyesj	1315	39	an	an	DT
cord-000248-zueoyesj	1315	40	early	early	JJ
cord-000248-zueoyesj	1315	41	somatic	somatic	JJ
cord-000248-zueoyesj	1315	42	DNA	dna	NN
cord-000248-zueoyesj	1315	43	alteration	alteration	NN
cord-000248-zueoyesj	1315	44	in	in	IN
cord-000248-zueoyesj	1315	45	human	human	JJ
cord-000248-zueoyesj	1315	46	prostate	prostate	NN
cord-000248-zueoyesj	1315	47	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1315	48	Role	role	NN
cord-000248-zueoyesj	1315	49	of	of	IN
cord-000248-zueoyesj	1315	50	telomere	telomere	NN
cord-000248-zueoyesj	1315	51	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1315	52	in	in	IN
cord-000248-zueoyesj	1315	53	aging	age	VBG
cord-000248-zueoyesj	1315	54	and	and	CC
cord-000248-zueoyesj	1315	55	its	-PRON-	PRP$
cord-000248-zueoyesj	1315	56	detection	detection	NN
cord-000248-zueoyesj	1315	57	by	by	IN
cord-000248-zueoyesj	1315	58	biomarkers	biomarker	NNS
cord-000248-zueoyesj	1315	59	Telomere	Telomere	NNP
cord-000248-zueoyesj	1315	60	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1315	61	and	and	CC
cord-000248-zueoyesj	1315	62	tumour	tumour	NN
cord-000248-zueoyesj	1315	63	suppression	suppression	NN
cord-000248-zueoyesj	1315	64	:	:	:
cord-000248-zueoyesj	1315	65	the	the	DT
cord-000248-zueoyesj	1315	66	senescence	senescence	NN
cord-000248-zueoyesj	1315	67	connection	connection	NN
cord-000248-zueoyesj	1316	1	Dual	dual	JJ
cord-000248-zueoyesj	1316	2	roles	role	NNS
cord-000248-zueoyesj	1316	3	of	of	IN
cord-000248-zueoyesj	1316	4	telomere	telomere	NN
cord-000248-zueoyesj	1316	5	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1316	6	in	in	IN
cord-000248-zueoyesj	1316	7	initiation	initiation	NN
cord-000248-zueoyesj	1316	8	and	and	CC
cord-000248-zueoyesj	1316	9	suppression	suppression	NN
cord-000248-zueoyesj	1316	10	of	of	IN
cord-000248-zueoyesj	1316	11	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1316	12	Telomere	telomere	NN
cord-000248-zueoyesj	1316	13	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1316	14	,	,	,
cord-000248-zueoyesj	1316	15	genome	genome	NN
cord-000248-zueoyesj	1316	16	instability	instability	NN
cord-000248-zueoyesj	1316	17	and	and	CC
cord-000248-zueoyesj	1316	18	cancer	cancer	NN
cord-000248-zueoyesj	1316	19	BRCA1	BRCA1	NNP
cord-000248-zueoyesj	1316	20	knock	knock	VB
cord-000248-zueoyesj	1316	21	-	-	HYPH
cord-000248-zueoyesj	1316	22	down	down	RP
cord-000248-zueoyesj	1316	23	causes	cause	NNS
cord-000248-zueoyesj	1316	24	telomere	telomere	NN
cord-000248-zueoyesj	1316	25	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1316	26	in	in	IN
cord-000248-zueoyesj	1316	27	mammary	mammary	JJ
cord-000248-zueoyesj	1316	28	epithelial	epithelial	JJ
cord-000248-zueoyesj	1316	29	cells	cell	NNS
cord-000248-zueoyesj	1316	30	Telomere	telomere	NN
cord-000248-zueoyesj	1316	31	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1316	32	in	in	IN
cord-000248-zueoyesj	1316	33	aging	aging	NN
cord-000248-zueoyesj	1316	34	and	and	CC
cord-000248-zueoyesj	1316	35	cancer	cancer	NN
cord-000248-zueoyesj	1316	36	Telomere	Telomere	NNP
cord-000248-zueoyesj	1316	37	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1316	38	increases	increase	VBZ
cord-000248-zueoyesj	1316	39	mutation	mutation	NN
cord-000248-zueoyesj	1316	40	rate	rate	NN
cord-000248-zueoyesj	1316	41	and	and	CC
cord-000248-zueoyesj	1316	42	genomic	genomic	JJ
cord-000248-zueoyesj	1316	43	instability	instability	NN
cord-000248-zueoyesj	1317	1	Telomere	telomere	NN
cord-000248-zueoyesj	1317	2	dysfunction	dysfunction	NN
cord-000248-zueoyesj	1317	3	triggers	trigger	VBZ
cord-000248-zueoyesj	1317	4	extensive	extensive	JJ
cord-000248-zueoyesj	1317	5	DNA	dna	NN
cord-000248-zueoyesj	1317	6	fragmentation	fragmentation	NN
cord-000248-zueoyesj	1317	7	and	and	CC
cord-000248-zueoyesj	1317	8	evolution	evolution	NN
cord-000248-zueoyesj	1317	9	of	of	IN
cord-000248-zueoyesj	1317	10	complex	complex	JJ
cord-000248-zueoyesj	1317	11	chromosome	chromosome	NN
cord-000248-zueoyesj	1317	12	abnormalities	abnormality	NNS
cord-000248-zueoyesj	1317	13	in	in	IN
cord-000248-zueoyesj	1317	14	human	human	JJ
cord-000248-zueoyesj	1317	15	malignant	malignant	JJ
cord-000248-zueoyesj	1317	16	tumors	tumor	NNS
cord-000248-zueoyesj	1317	17	DNA	dna	NN
cord-000248-zueoyesj	1317	18	damage	damage	NN
cord-000248-zueoyesj	1317	19	signalling	signalling	NN
cord-000248-zueoyesj	1317	20	prevents	prevent	VBZ
cord-000248-zueoyesj	1317	21	deleterious	deleterious	JJ
cord-000248-zueoyesj	1317	22	telomere	telomere	NN
cord-000248-zueoyesj	1317	23	addition	addition	NN
cord-000248-zueoyesj	1317	24	at	at	IN
cord-000248-zueoyesj	1317	25	DNA	dna	NN
cord-000248-zueoyesj	1317	26	breaks	break	NNS
cord-000248-zueoyesj	1318	1	The	the	DT
cord-000248-zueoyesj	1318	2	human	human	JJ
cord-000248-zueoyesj	1318	3	Rap1	Rap1	NNP
cord-000248-zueoyesj	1318	4	protein	protein	NN
cord-000248-zueoyesj	1318	5	complex	complex	NN
cord-000248-zueoyesj	1318	6	and	and	CC
cord-000248-zueoyesj	1318	7	modulation	modulation	NN
cord-000248-zueoyesj	1318	8	of	of	IN
cord-000248-zueoyesj	1318	9	telomere	telomere	NN
cord-000248-zueoyesj	1318	10	length	length	NN
cord-000248-zueoyesj	1319	1	Small	small	JJ
cord-000248-zueoyesj	1319	2	regulatory	regulatory	JJ
cord-000248-zueoyesj	1319	3	RNAs	rna	NNS
cord-000248-zueoyesj	1319	4	in	in	IN
cord-000248-zueoyesj	1319	5	mammals	mammal	NNS
cord-000248-zueoyesj	1319	6	Implications	implication	NNS
cord-000248-zueoyesj	1319	7	of	of	IN
cord-000248-zueoyesj	1319	8	micro	micro	JJ
cord-000248-zueoyesj	1319	9	-	-	JJ
cord-000248-zueoyesj	1319	10	RNA	RNA	NNP
cord-000248-zueoyesj	1319	11	profiling	profiling	NN
cord-000248-zueoyesj	1319	12	for	for	IN
cord-000248-zueoyesj	1320	1	cancer	cancer	NN
cord-000248-zueoyesj	1320	2	diagnosis	diagnosis	NN
cord-000248-zueoyesj	1320	3	miRNAs	miRNAs	NNP
cord-000248-zueoyesj	1320	4	:	:	:
cord-000248-zueoyesj	1320	5	Little	little	JJ
cord-000248-zueoyesj	1320	6	known	know	VBN
cord-000248-zueoyesj	1320	7	mediators	mediator	NNS
cord-000248-zueoyesj	1320	8	of	of	IN
cord-000248-zueoyesj	1320	9	oncogenesis	oncogenesis	NNP
cord-000248-zueoyesj	1320	10	Regulation	Regulation	NNP
cord-000248-zueoyesj	1320	11	of	of	IN
cord-000248-zueoyesj	1320	12	epidermal	epidermal	JJ
cord-000248-zueoyesj	1320	13	growth	growth	NN
cord-000248-zueoyesj	1320	14	factor	factor	NN
cord-000248-zueoyesj	1320	15	receptor	receptor	NN
cord-000248-zueoyesj	1320	16	signaling	signal	VBG
cord-000248-zueoyesj	1320	17	in	in	IN
cord-000248-zueoyesj	1320	18	human	human	JJ
cord-000248-zueoyesj	1320	19	cancer	cancer	NN
cord-000248-zueoyesj	1320	20	cells	cell	NNS
cord-000248-zueoyesj	1320	21	by	by	IN
cord-000248-zueoyesj	1320	22	microRNA-7	microRNA-7	NNP
cord-000248-zueoyesj	1320	23	MicroRNAs	MicroRNAs	NNP
cord-000248-zueoyesj	1320	24	and	and	CC
cord-000248-zueoyesj	1320	25	their	-PRON-	PRP$
cord-000248-zueoyesj	1320	26	potential	potential	NN
cord-000248-zueoyesj	1320	27	for	for	IN
cord-000248-zueoyesj	1320	28	translation	translation	NN
cord-000248-zueoyesj	1320	29	in	in	IN
cord-000248-zueoyesj	1320	30	prostate	prostate	NN
cord-000248-zueoyesj	1320	31	cancer	cancer	NN
cord-000248-zueoyesj	1320	32	MicroRNA	MicroRNA	NNP
cord-000248-zueoyesj	1320	33	expression	expression	NN
cord-000248-zueoyesj	1320	34	profiling	profile	VBG
cord-000248-zueoyesj	1320	35	in	in	IN
cord-000248-zueoyesj	1320	36	prostate	prostate	NN
cord-000248-zueoyesj	1320	37	cancer	cancer	NN
cord-000248-zueoyesj	1320	38	Clusters	cluster	NNS
cord-000248-zueoyesj	1320	39	of	of	IN
cord-000248-zueoyesj	1321	1	internally	internally	RB
cord-000248-zueoyesj	1321	2	primed	prime	VBN
cord-000248-zueoyesj	1321	3	transcripts	transcript	NNS
cord-000248-zueoyesj	1321	4	reveal	reveal	VBP
cord-000248-zueoyesj	1321	5	novel	novel	JJ
cord-000248-zueoyesj	1321	6	long	long	JJ
cord-000248-zueoyesj	1321	7	noncoding	noncoding	JJ
cord-000248-zueoyesj	1321	8	RNAs	rna	NNS
cord-000248-zueoyesj	1321	9	Long	long	RB
cord-000248-zueoyesj	1321	10	,	,	,
cord-000248-zueoyesj	1321	11	abundantly	abundantly	RB
cord-000248-zueoyesj	1321	12	expressed	express	VBN
cord-000248-zueoyesj	1321	13	non	non	JJ
cord-000248-zueoyesj	1321	14	-	-	JJ
cord-000248-zueoyesj	1321	15	coding	coding	JJ
cord-000248-zueoyesj	1321	16	transcripts	transcript	NNS
cord-000248-zueoyesj	1321	17	are	be	VBP
cord-000248-zueoyesj	1321	18	altered	alter	VBN
cord-000248-zueoyesj	1321	19	in	in	IN
cord-000248-zueoyesj	1321	20	cancer	cancer	NN
cord-000248-zueoyesj	1321	21	Long	long	JJ
cord-000248-zueoyesj	1321	22	non	non	JJ
cord-000248-zueoyesj	1321	23	-	-	JJ
cord-000248-zueoyesj	1321	24	coding	coding	JJ
cord-000248-zueoyesj	1321	25	RNAs	rna	NNS
cord-000248-zueoyesj	1321	26	:	:	:
cord-000248-zueoyesj	1321	27	insights	insight	NNS
cord-000248-zueoyesj	1321	28	into	into	IN
cord-000248-zueoyesj	1321	29	functions	function	NNS
cord-000248-zueoyesj	1321	30	RNA	RNA	NNP
cord-000248-zueoyesj	1321	31	regulation	regulation	NN
cord-000248-zueoyesj	1321	32	of	of	IN
cord-000248-zueoyesj	1321	33	epigenetic	epigenetic	JJ
cord-000248-zueoyesj	1321	34	processes	process	NNS
cord-000248-zueoyesj	1322	1	The	the	DT
cord-000248-zueoyesj	1322	2	genetic	genetic	JJ
cord-000248-zueoyesj	1322	3	signatures	signature	NNS
cord-000248-zueoyesj	1322	4	of	of	IN
cord-000248-zueoyesj	1322	5	noncoding	noncoding	JJ
cord-000248-zueoyesj	1322	6	RNAs	rna	NNS
cord-000248-zueoyesj	1322	7	39	39	CD
cord-000248-zueoyesj	1322	8	end	end	NN
cord-000248-zueoyesj	1322	9	processing	processing	NN
cord-000248-zueoyesj	1322	10	of	of	IN
cord-000248-zueoyesj	1322	11	a	a	DT
cord-000248-zueoyesj	1322	12	long	long	JJ
cord-000248-zueoyesj	1322	13	nuclearretained	nuclearretained	JJ
cord-000248-zueoyesj	1322	14	noncoding	noncoding	NNP
cord-000248-zueoyesj	1322	15	RNA	RNA	NNP
cord-000248-zueoyesj	1322	16	yields	yield	VBZ
cord-000248-zueoyesj	1322	17	a	a	DT
cord-000248-zueoyesj	1322	18	tRNA	trna	NN
cord-000248-zueoyesj	1322	19	-	-	HYPH
cord-000248-zueoyesj	1322	20	like	like	JJ
cord-000248-zueoyesj	1322	21	cytoplasmic	cytoplasmic	JJ
cord-000248-zueoyesj	1322	22	RNA	RNA	NNP
cord-000248-zueoyesj	1322	23	DNA	dna	NN
cord-000248-zueoyesj	1322	24	sequence	sequence	NN
cord-000248-zueoyesj	1322	25	of	of	IN
cord-000248-zueoyesj	1322	26	the	the	DT
cord-000248-zueoyesj	1322	27	translocation	translocation	NN
cord-000248-zueoyesj	1322	28	breakpoints	breakpoint	NNS
cord-000248-zueoyesj	1322	29	in	in	IN
cord-000248-zueoyesj	1322	30	undifferentiated	undifferentiated	JJ
cord-000248-zueoyesj	1322	31	embryonal	embryonal	JJ
cord-000248-zueoyesj	1322	32	sarcoma	sarcoma	NN
cord-000248-zueoyesj	1322	33	arising	arise	VBG
cord-000248-zueoyesj	1322	34	in	in	IN
cord-000248-zueoyesj	1322	35	mesenchymal	mesenchymal	JJ
cord-000248-zueoyesj	1322	36	hamartoma	hamartoma	NN
cord-000248-zueoyesj	1322	37	of	of	IN
cord-000248-zueoyesj	1322	38	the	the	DT
cord-000248-zueoyesj	1322	39	liver	liver	NN
cord-000248-zueoyesj	1322	40	harboring	harbor	VBG
cord-000248-zueoyesj	1322	41	the	the	DT
cord-000248-zueoyesj	1322	42	t(11;19)(q11;q13.4	t(11;19)(q11;q13.4	NNP
cord-000248-zueoyesj	1322	43	)	)	-RRB-
cord-000248-zueoyesj	1322	44	translocation	translocation	NN
cord-000248-zueoyesj	1322	45	Transcriptomic	Transcriptomic	NNP
cord-000248-zueoyesj	1322	46	and	and	CC
cord-000248-zueoyesj	1322	47	genomic	genomic	JJ
cord-000248-zueoyesj	1322	48	analysis	analysis	NN
cord-000248-zueoyesj	1322	49	of	of	IN
cord-000248-zueoyesj	1322	50	human	human	JJ
cord-000248-zueoyesj	1322	51	hepatocellular	hepatocellular	JJ
cord-000248-zueoyesj	1322	52	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1322	53	and	and	CC
cord-000248-zueoyesj	1322	54	hepatoblastomas	hepatoblastomas	NNP
cord-000248-zueoyesj	1322	55	A	a	DT
cord-000248-zueoyesj	1322	56	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1322	57	sketch	sketch	NN
cord-000248-zueoyesj	1322	58	of	of	IN
cord-000248-zueoyesj	1322	59	a	a	DT
cord-000248-zueoyesj	1322	60	primary	primary	JJ
cord-000248-zueoyesj	1322	61	human	human	JJ
cord-000248-zueoyesj	1322	62	breast	breast	NN
cord-000248-zueoyesj	1322	63	cancer	cancer	NN
cord-000248-zueoyesj	1322	64	by	by	IN
cord-000248-zueoyesj	1322	65	454	454	CD
cord-000248-zueoyesj	1322	66	deep	deep	JJ
cord-000248-zueoyesj	1322	67	sequencing	sequencing	NN
cord-000248-zueoyesj	1322	68	Metastasis	metastasis	NN
cord-000248-zueoyesj	1322	69	associated	associate	VBD
cord-000248-zueoyesj	1322	70	lung	lung	NN
cord-000248-zueoyesj	1322	71	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1322	72	transcript	transcript	NN
cord-000248-zueoyesj	1322	73	1	1	CD
cord-000248-zueoyesj	1322	74	(	(	-LRB-
cord-000248-zueoyesj	1322	75	MALAT-1	MALAT-1	NNP
cord-000248-zueoyesj	1322	76	)	)	-RRB-
cord-000248-zueoyesj	1323	1	is	be	VBZ
cord-000248-zueoyesj	1323	2	up	up	RB
cord-000248-zueoyesj	1323	3	-	-	HYPH
cord-000248-zueoyesj	1323	4	regulated	regulate	VBN
cord-000248-zueoyesj	1323	5	in	in	IN
cord-000248-zueoyesj	1323	6	placenta	placenta	NN
cord-000248-zueoyesj	1323	7	previa	previa	NN
cord-000248-zueoyesj	1323	8	increta	increta	JJ
cord-000248-zueoyesj	1323	9	/	/	SYM
cord-000248-zueoyesj	1323	10	percreta	percreta	NN
cord-000248-zueoyesj	1323	11	and	and	CC
cord-000248-zueoyesj	1323	12	strongly	strongly	RB
cord-000248-zueoyesj	1323	13	associated	associate	VBN
cord-000248-zueoyesj	1323	14	with	with	IN
cord-000248-zueoyesj	1323	15	trophoblast	trophoblast	NN
cord-000248-zueoyesj	1323	16	-	-	HYPH
cord-000248-zueoyesj	1323	17	like	like	JJ
cord-000248-zueoyesj	1323	18	cell	cell	NN
cord-000248-zueoyesj	1323	19	invasion	invasion	NN
cord-000248-zueoyesj	1323	20	in	in	IN
cord-000248-zueoyesj	1323	21	vitro	vitro	FW
cord-000248-zueoyesj	1324	1	Elucidating	elucidate	VBG
cord-000248-zueoyesj	1324	2	the	the	DT
cord-000248-zueoyesj	1324	3	molecular	molecular	JJ
cord-000248-zueoyesj	1324	4	physiopathology	physiopathology	NN
cord-000248-zueoyesj	1324	5	of	of	IN
cord-000248-zueoyesj	1324	6	acute	acute	JJ
cord-000248-zueoyesj	1324	7	respiratory	respiratory	JJ
cord-000248-zueoyesj	1324	8	distress	distress	NN
cord-000248-zueoyesj	1324	9	syndrome	syndrome	NN
cord-000248-zueoyesj	1324	10	in	in	IN
cord-000248-zueoyesj	1324	11	severe	severe	JJ
cord-000248-zueoyesj	1324	12	acute	acute	JJ
cord-000248-zueoyesj	1324	13	respiratory	respiratory	JJ
cord-000248-zueoyesj	1324	14	syndrome	syndrome	NN
cord-000248-zueoyesj	1324	15	patients	patient	VBZ
cord-000248-zueoyesj	1324	16	Expression	Expression	NNP
cord-000248-zueoyesj	1324	17	profile	profile	NN
cord-000248-zueoyesj	1324	18	of	of	IN
cord-000248-zueoyesj	1324	19	microRNAs	microRNAs	NNPS
cord-000248-zueoyesj	1324	20	in	in	IN
cord-000248-zueoyesj	1324	21	c	c	NNP
cord-000248-zueoyesj	1324	22	-	-	HYPH
cord-000248-zueoyesj	1324	23	Myc	Myc	NNP
cord-000248-zueoyesj	1325	1	induced	induce	VBN
cord-000248-zueoyesj	1325	2	mouse	mouse	NN
cord-000248-zueoyesj	1325	3	mammary	mammary	JJ
cord-000248-zueoyesj	1325	4	tumors	tumor	NNS
cord-000248-zueoyesj	1325	5	Prognostic	prognostic	JJ
cord-000248-zueoyesj	1325	6	significance	significance	NN
cord-000248-zueoyesj	1325	7	of	of	IN
cord-000248-zueoyesj	1325	8	drug	drug	NN
cord-000248-zueoyesj	1325	9	-	-	HYPH
cord-000248-zueoyesj	1325	10	regulated	regulate	VBN
cord-000248-zueoyesj	1325	11	genes	gene	NNS
cord-000248-zueoyesj	1325	12	in	in	IN
cord-000248-zueoyesj	1325	13	high	high	JJ
cord-000248-zueoyesj	1325	14	-	-	HYPH
cord-000248-zueoyesj	1325	15	grade	grade	NN
cord-000248-zueoyesj	1325	16	osteosarcoma	osteosarcoma	NN
cord-000248-zueoyesj	1326	1	A	a	DT
cord-000248-zueoyesj	1326	2	screen	screen	NN
cord-000248-zueoyesj	1326	3	for	for	IN
cord-000248-zueoyesj	1326	4	nuclear	nuclear	JJ
cord-000248-zueoyesj	1326	5	transcripts	transcript	NNS
cord-000248-zueoyesj	1326	6	identifies	identify	VBZ
cord-000248-zueoyesj	1326	7	two	two	CD
cord-000248-zueoyesj	1326	8	linked	link	VBN
cord-000248-zueoyesj	1326	9	noncoding	noncoding	JJ
cord-000248-zueoyesj	1326	10	RNAs	rna	NNS
cord-000248-zueoyesj	1326	11	associated	associate	VBN
cord-000248-zueoyesj	1326	12	with	with	IN
cord-000248-zueoyesj	1326	13	SC35	SC35	NNP
cord-000248-zueoyesj	1326	14	splicing	splicing	NN
cord-000248-zueoyesj	1326	15	domains	domain	NNS
cord-000248-zueoyesj	1327	1	A	a	DT
cord-000248-zueoyesj	1327	2	large	large	JJ
cord-000248-zueoyesj	1327	3	noncoding	noncoding	JJ
cord-000248-zueoyesj	1327	4	RNA	RNA	NNP
cord-000248-zueoyesj	1327	5	is	be	VBZ
cord-000248-zueoyesj	1327	6	a	a	DT
cord-000248-zueoyesj	1327	7	marker	marker	NN
cord-000248-zueoyesj	1327	8	for	for	IN
cord-000248-zueoyesj	1327	9	murine	murine	JJ
cord-000248-zueoyesj	1327	10	hepatocellular	hepatocellular	JJ
cord-000248-zueoyesj	1327	11	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1327	12	and	and	CC
cord-000248-zueoyesj	1327	13	a	a	DT
cord-000248-zueoyesj	1327	14	spectrum	spectrum	NN
cord-000248-zueoyesj	1327	15	of	of	IN
cord-000248-zueoyesj	1327	16	human	human	JJ
cord-000248-zueoyesj	1327	17	carcinomas	carcinoma	NNS
cord-000248-zueoyesj	1327	18	Phenotypic	phenotypic	JJ
cord-000248-zueoyesj	1327	19	characterization	characterization	NN
cord-000248-zueoyesj	1327	20	of	of	IN
cord-000248-zueoyesj	1327	21	endometrial	endometrial	JJ
cord-000248-zueoyesj	1327	22	stromal	stromal	JJ
cord-000248-zueoyesj	1327	23	sarcoma	sarcoma	NN
cord-000248-zueoyesj	1327	24	of	of	IN
cord-000248-zueoyesj	1327	25	the	the	DT
cord-000248-zueoyesj	1327	26	uterus	uterus	NN
cord-000248-zueoyesj	1327	27	Genome	genome	NN
cord-000248-zueoyesj	1327	28	-	-	HYPH
cord-000248-zueoyesj	1327	29	wide	wide	JJ
cord-000248-zueoyesj	1327	30	screening	screening	NN
cord-000248-zueoyesj	1327	31	for	for	IN
cord-000248-zueoyesj	1327	32	prognosis	prognosis	NN
cord-000248-zueoyesj	1327	33	-	-	HYPH
cord-000248-zueoyesj	1327	34	predicting	predict	VBG
cord-000248-zueoyesj	1327	35	genes	gene	NNS
cord-000248-zueoyesj	1327	36	in	in	IN
cord-000248-zueoyesj	1327	37	early	early	JJ
cord-000248-zueoyesj	1327	38	-	-	HYPH
cord-000248-zueoyesj	1327	39	stage	stage	NN
cord-000248-zueoyesj	1327	40	non	non	JJ
cord-000248-zueoyesj	1327	41	-	-	JJ
cord-000248-zueoyesj	1327	42	small	small	JJ
cord-000248-zueoyesj	1327	43	-	-	HYPH
cord-000248-zueoyesj	1327	44	cell	cell	NN
cord-000248-zueoyesj	1327	45	lung	lung	NN
cord-000248-zueoyesj	1327	46	cancer	cancer	NN
cord-000248-zueoyesj	1327	47	MALAT-1	MALAT-1	NNP
cord-000248-zueoyesj	1327	48	,	,	,
cord-000248-zueoyesj	1327	49	a	a	DT
cord-000248-zueoyesj	1327	50	novel	novel	NN
cord-000248-zueoyesj	1327	51	noncoding	noncoding	NNP
cord-000248-zueoyesj	1327	52	RNA	RNA	NNP
cord-000248-zueoyesj	1327	53	,	,	,
cord-000248-zueoyesj	1327	54	and	and	CC
cord-000248-zueoyesj	1327	55	thymosin	thymosin	NN
cord-000248-zueoyesj	1327	56	beta4	beta4	NN
cord-000248-zueoyesj	1327	57	predict	predict	VBP
cord-000248-zueoyesj	1327	58	metastasis	metastasis	NN
cord-000248-zueoyesj	1327	59	and	and	CC
cord-000248-zueoyesj	1327	60	survival	survival	NN
cord-000248-zueoyesj	1327	61	in	in	IN
cord-000248-zueoyesj	1327	62	early	early	JJ
cord-000248-zueoyesj	1327	63	-	-	HYPH
cord-000248-zueoyesj	1327	64	stage	stage	NN
cord-000248-zueoyesj	1327	65	non	non	JJ
cord-000248-zueoyesj	1327	66	-	-	JJ
cord-000248-zueoyesj	1327	67	small	small	JJ
cord-000248-zueoyesj	1327	68	cell	cell	NN
cord-000248-zueoyesj	1327	69	lung	lung	NN
cord-000248-zueoyesj	1327	70	cancer	cancer	NN
cord-000248-zueoyesj	1328	1	The	the	DT
cord-000248-zueoyesj	1328	2	interaction	interaction	NN
cord-000248-zueoyesj	1328	3	profile	profile	NN
cord-000248-zueoyesj	1328	4	of	of	IN
cord-000248-zueoyesj	1328	5	homologous	homologous	JJ
cord-000248-zueoyesj	1328	6	recombination	recombination	NN
cord-000248-zueoyesj	1328	7	repair	repair	NN
cord-000248-zueoyesj	1328	8	proteins	protein	NNS
cord-000248-zueoyesj	1328	9	RAD51C	RAD51C	NNS
cord-000248-zueoyesj	1328	10	,	,	,
cord-000248-zueoyesj	1328	11	RAD51D	RAD51D	NNP
cord-000248-zueoyesj	1328	12	and	and	CC
cord-000248-zueoyesj	1328	13	XRCC2	XRCC2	NNP
cord-000248-zueoyesj	1328	14	as	as	IN
cord-000248-zueoyesj	1328	15	determined	determine	VBN
cord-000248-zueoyesj	1328	16	by	by	IN
cord-000248-zueoyesj	1328	17	proteomic	proteomic	JJ
cord-000248-zueoyesj	1328	18	analysis	analysis	NN
cord-000248-zueoyesj	1328	19	Paraspeckles	Paraspeckles	NNP
cord-000248-zueoyesj	1328	20	:	:	:
cord-000248-zueoyesj	1328	21	nuclear	nuclear	JJ
cord-000248-zueoyesj	1328	22	bodies	body	NNS
cord-000248-zueoyesj	1328	23	built	build	VBN
cord-000248-zueoyesj	1328	24	on	on	IN
cord-000248-zueoyesj	1328	25	long	long	JJ
cord-000248-zueoyesj	1328	26	noncoding	noncoding	JJ
cord-000248-zueoyesj	1328	27	RNA	RNA	NNP
cord-000248-zueoyesj	1328	28	hnRNP	hnrnp	NN
cord-000248-zueoyesj	1328	29	M	M	NNP
cord-000248-zueoyesj	1328	30	interacts	interact	VBZ
cord-000248-zueoyesj	1328	31	with	with	IN
cord-000248-zueoyesj	1328	32	PSF	PSF	NNP
cord-000248-zueoyesj	1328	33	and	and	CC
cord-000248-zueoyesj	1328	34	p54(nrb	p54(nrb	NNP
cord-000248-zueoyesj	1328	35	)	)	-RRB-
cord-000248-zueoyesj	1328	36	and	and	CC
cord-000248-zueoyesj	1328	37	co	co	NNS
cord-000248-zueoyesj	1328	38	-	-	NN
cord-000248-zueoyesj	1328	39	localizes	localizes	RB
cord-000248-zueoyesj	1329	1	within	within	IN
cord-000248-zueoyesj	1329	2	defined	define	VBN
cord-000248-zueoyesj	1329	3	nuclear	nuclear	JJ
cord-000248-zueoyesj	1329	4	structures	structure	NNS
cord-000248-zueoyesj	1329	5	Altered	alter	VBD
cord-000248-zueoyesj	1329	6	nuclear	nuclear	JJ
cord-000248-zueoyesj	1329	7	retention	retention	NN
cord-000248-zueoyesj	1329	8	of	of	IN
cord-000248-zueoyesj	1329	9	mRNAs	mRNAs	NNPS
cord-000248-zueoyesj	1329	10	containing	contain	VBG
cord-000248-zueoyesj	1329	11	inverted	invert	VBN
cord-000248-zueoyesj	1329	12	repeats	repeat	NNS
cord-000248-zueoyesj	1329	13	in	in	IN
cord-000248-zueoyesj	1329	14	human	human	JJ
cord-000248-zueoyesj	1329	15	embryonic	embryonic	JJ
cord-000248-zueoyesj	1329	16	stem	stem	NN
cord-000248-zueoyesj	1329	17	cells	cell	NNS
cord-000248-zueoyesj	1329	18	:	:	:
cord-000248-zueoyesj	1329	19	functional	functional	JJ
cord-000248-zueoyesj	1329	20	role	role	NN
cord-000248-zueoyesj	1329	21	of	of	IN
cord-000248-zueoyesj	1329	22	a	a	DT
cord-000248-zueoyesj	1329	23	nuclear	nuclear	JJ
cord-000248-zueoyesj	1329	24	noncoding	noncoding	JJ
cord-000248-zueoyesj	1329	25	RNA	RNA	NNP
cord-000248-zueoyesj	1329	26	How	how	WRB
cord-000248-zueoyesj	1329	27	to	to	TO
cord-000248-zueoyesj	1329	28	build	build	VB
cord-000248-zueoyesj	1329	29	a	a	DT
cord-000248-zueoyesj	1329	30	paraspeckle	paraspeckle	NN
cord-000248-zueoyesj	1329	31	An	an	DT
cord-000248-zueoyesj	1329	32	architectural	architectural	JJ
cord-000248-zueoyesj	1329	33	role	role	NN
cord-000248-zueoyesj	1329	34	for	for	IN
cord-000248-zueoyesj	1329	35	a	a	DT
cord-000248-zueoyesj	1329	36	nuclear	nuclear	JJ
cord-000248-zueoyesj	1329	37	noncoding	noncoding	JJ
cord-000248-zueoyesj	1329	38	RNA	rna	NN
cord-000248-zueoyesj	1329	39	:	:	:
cord-000248-zueoyesj	1330	1	NEAT1	NEAT1	NNP
cord-000248-zueoyesj	1331	1	RNA	RNA	NNP
cord-000248-zueoyesj	1331	2	is	be	VBZ
cord-000248-zueoyesj	1331	3	essential	essential	JJ
cord-000248-zueoyesj	1331	4	for	for	IN
cord-000248-zueoyesj	1331	5	the	the	DT
cord-000248-zueoyesj	1331	6	structure	structure	NN
cord-000248-zueoyesj	1331	7	of	of	IN
cord-000248-zueoyesj	1331	8	paraspeckles	paraspeckles	NNP
cord-000248-zueoyesj	1331	9	MENepsilon/	MENepsilon/	NNP
cord-000248-zueoyesj	1332	1	beta	beta	JJ
cord-000248-zueoyesj	1332	2	noncoding	noncoding	JJ
cord-000248-zueoyesj	1332	3	RNAs	rna	NNS
cord-000248-zueoyesj	1332	4	are	be	VBP
cord-000248-zueoyesj	1332	5	essential	essential	JJ
cord-000248-zueoyesj	1332	6	for	for	IN
cord-000248-zueoyesj	1332	7	structural	structural	JJ
cord-000248-zueoyesj	1332	8	integrity	integrity	NN
cord-000248-zueoyesj	1332	9	of	of	IN
cord-000248-zueoyesj	1332	10	nuclear	nuclear	JJ
cord-000248-zueoyesj	1332	11	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	1332	12	MEN	men	NN
cord-000248-zueoyesj	1332	13	epsilon	epsilon	NN
cord-000248-zueoyesj	1332	14	/	/	SYM
cord-000248-zueoyesj	1332	15	beta	beta	NN
cord-000248-zueoyesj	1332	16	nuclear	nuclear	NN
cord-000248-zueoyesj	1332	17	-	-	HYPH
cord-000248-zueoyesj	1332	18	retained	retain	VBN
cord-000248-zueoyesj	1332	19	non	non	JJ
cord-000248-zueoyesj	1332	20	-	-	JJ
cord-000248-zueoyesj	1332	21	coding	coding	JJ
cord-000248-zueoyesj	1332	22	RNAs	rna	NNS
cord-000248-zueoyesj	1332	23	are	be	VBP
cord-000248-zueoyesj	1332	24	up	up	RB
cord-000248-zueoyesj	1332	25	-	-	HYPH
cord-000248-zueoyesj	1332	26	regulated	regulate	VBN
cord-000248-zueoyesj	1332	27	upon	upon	IN
cord-000248-zueoyesj	1332	28	muscle	muscle	NN
cord-000248-zueoyesj	1332	29	differentiation	differentiation	NN
cord-000248-zueoyesj	1332	30	and	and	CC
cord-000248-zueoyesj	1332	31	are	be	VBP
cord-000248-zueoyesj	1332	32	essential	essential	JJ
cord-000248-zueoyesj	1332	33	components	component	NNS
cord-000248-zueoyesj	1332	34	of	of	IN
cord-000248-zueoyesj	1332	35	paraspeckles	paraspeckles	NNP
cord-000248-zueoyesj	1332	36	nuclear	nuclear	JJ
cord-000248-zueoyesj	1332	37	domains	domain	NNS
cord-000248-zueoyesj	1332	38	:	:	:
cord-000248-zueoyesj	1332	39	characterization	characterization	NN
cord-000248-zueoyesj	1332	40	and	and	CC
cord-000248-zueoyesj	1332	41	dynamics	dynamic	NNS
cord-000248-zueoyesj	1332	42	as	as	IN
cord-000248-zueoyesj	1332	43	a	a	DT
cord-000248-zueoyesj	1332	44	function	function	NN
cord-000248-zueoyesj	1332	45	of	of	IN
cord-000248-zueoyesj	1332	46	transcriptional	transcriptional	JJ
cord-000248-zueoyesj	1332	47	activity	activity	NN
cord-000248-zueoyesj	1332	48	Subnuclear	Subnuclear	NNP
cord-000248-zueoyesj	1332	49	localization	localization	NN
cord-000248-zueoyesj	1332	50	and	and	CC
cord-000248-zueoyesj	1332	51	dynamics	dynamic	NNS
cord-000248-zueoyesj	1332	52	of	of	IN
cord-000248-zueoyesj	1332	53	the	the	DT
cord-000248-zueoyesj	1332	54	Pre	Pre	NNP
cord-000248-zueoyesj	1332	55	-	-	NNP
cord-000248-zueoyesj	1332	56	mRNA	mRNA	NNP
cord-000248-zueoyesj	1332	57	39	39	CD
cord-000248-zueoyesj	1332	58	end	end	NN
cord-000248-zueoyesj	1332	59	processing	processing	NN
cord-000248-zueoyesj	1332	60	factor	factor	NN
cord-000248-zueoyesj	1332	61	mammalian	mammalian	JJ
cord-000248-zueoyesj	1332	62	cleavage	cleavage	NN
cord-000248-zueoyesj	1332	63	factor	factor	NN
cord-000248-zueoyesj	1333	1	I	-PRON-	PRP
cord-000248-zueoyesj	1333	2	68-kDa	68-kda	CD
cord-000248-zueoyesj	1333	3	subunit	subunit	NN
cord-000248-zueoyesj	1333	4	Functional	functional	JJ
cord-000248-zueoyesj	1333	5	studies	study	NNS
cord-000248-zueoyesj	1333	6	of	of	IN
cord-000248-zueoyesj	1333	7	BCL11A	bcl11a	NN
cord-000248-zueoyesj	1333	8	:	:	:
cord-000248-zueoyesj	1333	9	characterization	characterization	NN
cord-000248-zueoyesj	1333	10	of	of	IN
cord-000248-zueoyesj	1333	11	the	the	DT
cord-000248-zueoyesj	1333	12	conserved	conserve	VBN
cord-000248-zueoyesj	1333	13	BCL11A	bcl11a	NN
cord-000248-zueoyesj	1333	14	-	-	HYPH
cord-000248-zueoyesj	1333	15	XL	xl	NN
cord-000248-zueoyesj	1333	16	splice	splice	NN
cord-000248-zueoyesj	1333	17	variant	variant	NN
cord-000248-zueoyesj	1333	18	and	and	CC
cord-000248-zueoyesj	1333	19	its	-PRON-	PRP$
cord-000248-zueoyesj	1333	20	interaction	interaction	NN
cord-000248-zueoyesj	1333	21	with	with	IN
cord-000248-zueoyesj	1333	22	BCL6	BCL6	NNP
cord-000248-zueoyesj	1333	23	in	in	IN
cord-000248-zueoyesj	1333	24	nuclear	nuclear	JJ
cord-000248-zueoyesj	1333	25	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	1333	26	of	of	IN
cord-000248-zueoyesj	1333	27	germinal	germinal	JJ
cord-000248-zueoyesj	1333	28	center	center	NN
cord-000248-zueoyesj	1333	29	B	B	NNP
cord-000248-zueoyesj	1333	30	cells	cell	NNS
cord-000248-zueoyesj	1334	1	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-000248-zueoyesj	1334	2	transport	transport	NN
cord-000248-zueoyesj	1334	3	of	of	IN
cord-000248-zueoyesj	1334	4	fluorescent	fluorescent	NN
cord-000248-zueoyesj	1334	5	mRNA	mrna	NN
cord-000248-zueoyesj	1334	6	in	in	IN
cord-000248-zueoyesj	1334	7	living	live	VBG
cord-000248-zueoyesj	1334	8	mammalian	mammalian	JJ
cord-000248-zueoyesj	1334	9	cells	cell	NNS
cord-000248-zueoyesj	1334	10	:	:	:
cord-000248-zueoyesj	1335	1	nuclear	nuclear	JJ
cord-000248-zueoyesj	1335	2	mRNA	mRNA	NNP
cord-000248-zueoyesj	1335	3	export	export	NN
cord-000248-zueoyesj	1335	4	is	be	VBZ
cord-000248-zueoyesj	1335	5	coupled	couple	VBN
cord-000248-zueoyesj	1335	6	to	to	IN
cord-000248-zueoyesj	1335	7	ongoing	ongoing	JJ
cord-000248-zueoyesj	1335	8	gene	gene	NN
cord-000248-zueoyesj	1335	9	transcription	transcription	NN
cord-000248-zueoyesj	1335	10	Splicing	splicing	NN
cord-000248-zueoyesj	1335	11	speckles	speckle	NNS
cord-000248-zueoyesj	1335	12	are	be	VBP
cord-000248-zueoyesj	1335	13	not	not	RB
cord-000248-zueoyesj	1335	14	reservoirs	reservoir	NNS
cord-000248-zueoyesj	1335	15	of	of	IN
cord-000248-zueoyesj	1335	16	RNA	RNA	NNP
cord-000248-zueoyesj	1335	17	polymerase	polymerase	NN
cord-000248-zueoyesj	1335	18	II	II	NNP
cord-000248-zueoyesj	1335	19	,	,	,
cord-000248-zueoyesj	1335	20	but	but	CC
cord-000248-zueoyesj	1335	21	contain	contain	VBP
cord-000248-zueoyesj	1335	22	an	an	DT
cord-000248-zueoyesj	1335	23	inactive	inactive	JJ
cord-000248-zueoyesj	1335	24	form	form	NN
cord-000248-zueoyesj	1335	25	,	,	,
cord-000248-zueoyesj	1335	26	phosphorylated	phosphorylate	VBN
cord-000248-zueoyesj	1335	27	on	on	IN
cord-000248-zueoyesj	1335	28	serine2	serine2	JJ
cord-000248-zueoyesj	1335	29	residues	residue	NNS
cord-000248-zueoyesj	1335	30	of	of	IN
cord-000248-zueoyesj	1335	31	the	the	DT
cord-000248-zueoyesj	1335	32	C	C	NNP
cord-000248-zueoyesj	1335	33	-	-	HYPH
cord-000248-zueoyesj	1335	34	terminal	terminal	NN
cord-000248-zueoyesj	1335	35	domain	domain	NN
cord-000248-zueoyesj	1335	36	Regulating	regulate	VBG
cord-000248-zueoyesj	1335	37	gene	gene	NN
cord-000248-zueoyesj	1335	38	expression	expression	NN
cord-000248-zueoyesj	1335	39	through	through	IN
cord-000248-zueoyesj	1335	40	RNA	RNA	NNP
cord-000248-zueoyesj	1335	41	nuclear	nuclear	JJ
cord-000248-zueoyesj	1335	42	retention	retention	NN
cord-000248-zueoyesj	1335	43	P54nrb	P54nrb	NNP
cord-000248-zueoyesj	1335	44	forms	form	VBZ
cord-000248-zueoyesj	1335	45	a	a	DT
cord-000248-zueoyesj	1335	46	heterodimer	heterodimer	NN
cord-000248-zueoyesj	1335	47	with	with	IN
cord-000248-zueoyesj	1335	48	PSP1	PSP1	NNP
cord-000248-zueoyesj	1335	49	that	that	WDT
cord-000248-zueoyesj	1335	50	localizes	localize	VBZ
cord-000248-zueoyesj	1335	51	to	to	IN
cord-000248-zueoyesj	1335	52	paraspeckles	paraspeckle	NNS
cord-000248-zueoyesj	1335	53	in	in	IN
cord-000248-zueoyesj	1335	54	an	an	DT
cord-000248-zueoyesj	1335	55	RNA	RNA	NNP
cord-000248-zueoyesj	1335	56	-	-	HYPH
cord-000248-zueoyesj	1335	57	dependent	dependent	JJ
cord-000248-zueoyesj	1335	58	manner	manner	NN
cord-000248-zueoyesj	1335	59	Dynamics	dynamic	NNS
cord-000248-zueoyesj	1335	60	of	of	IN
cord-000248-zueoyesj	1335	61	the	the	DT
cord-000248-zueoyesj	1335	62	mammalian	mammalian	JJ
cord-000248-zueoyesj	1335	63	nucleus	nucleus	NN
cord-000248-zueoyesj	1335	64	:	:	:
cord-000248-zueoyesj	1335	65	can	can	MD
cord-000248-zueoyesj	1335	66	microscopic	microscopic	JJ
cord-000248-zueoyesj	1335	67	movements	movement	NNS
cord-000248-zueoyesj	1335	68	help	help	VB
cord-000248-zueoyesj	1335	69	us	-PRON-	PRP
cord-000248-zueoyesj	1335	70	to	to	TO
cord-000248-zueoyesj	1335	71	understand	understand	VB
cord-000248-zueoyesj	1335	72	our	-PRON-	PRP$
cord-000248-zueoyesj	1335	73	genes	gene	NNS
cord-000248-zueoyesj	1335	74	?	?	.
cord-000248-zueoyesj	1336	1	Distinct	distinct	JJ
cord-000248-zueoyesj	1336	2	sequence	sequence	NN
cord-000248-zueoyesj	1336	3	motifs	motif	NNS
cord-000248-zueoyesj	1336	4	within	within	IN
cord-000248-zueoyesj	1336	5	the	the	DT
cord-000248-zueoyesj	1336	6	68-kDa	68-kda	CD
cord-000248-zueoyesj	1336	7	subunit	subunit	NN
cord-000248-zueoyesj	1336	8	of	of	IN
cord-000248-zueoyesj	1336	9	cleavage	cleavage	NN
cord-000248-zueoyesj	1336	10	factor	factor	NN
cord-000248-zueoyesj	1337	1	I	-PRON-	PRP
cord-000248-zueoyesj	1337	2	m	be	VBP
cord-000248-zueoyesj	1337	3	mediate	mediate	NNP
cord-000248-zueoyesj	1337	4	RNA	RNA	NNP
cord-000248-zueoyesj	1337	5	binding	binding	NN
cord-000248-zueoyesj	1337	6	,	,	,
cord-000248-zueoyesj	1337	7	protein	protein	NN
cord-000248-zueoyesj	1337	8	-	-	HYPH
cord-000248-zueoyesj	1337	9	protein	protein	NN
cord-000248-zueoyesj	1337	10	interactions	interaction	NNS
cord-000248-zueoyesj	1337	11	,	,	,
cord-000248-zueoyesj	1337	12	and	and	CC
cord-000248-zueoyesj	1337	13	subcellular	subcellular	JJ
cord-000248-zueoyesj	1337	14	localization	localization	NN
cord-000248-zueoyesj	1337	15	Nucleolomics	Nucleolomics	NNPS
cord-000248-zueoyesj	1337	16	:	:	:
cord-000248-zueoyesj	1337	17	an	an	DT
cord-000248-zueoyesj	1337	18	inventory	inventory	NN
cord-000248-zueoyesj	1337	19	of	of	IN
cord-000248-zueoyesj	1337	20	the	the	DT
cord-000248-zueoyesj	1337	21	nucleolus	nucleolus	NN
cord-000248-zueoyesj	1337	22	Paraspeckles	Paraspeckles	NNP
cord-000248-zueoyesj	1337	23	:	:	:
cord-000248-zueoyesj	1337	24	a	a	DT
cord-000248-zueoyesj	1337	25	novel	novel	JJ
cord-000248-zueoyesj	1337	26	nuclear	nuclear	JJ
cord-000248-zueoyesj	1337	27	domain	domain	NN
cord-000248-zueoyesj	1338	1	A	a	DT
cord-000248-zueoyesj	1338	2	NEAT	neat	JJ
cord-000248-zueoyesj	1338	3	way	way	NN
cord-000248-zueoyesj	1338	4	of	of	IN
cord-000248-zueoyesj	1338	5	regulating	regulate	VBG
cord-000248-zueoyesj	1338	6	nuclear	nuclear	JJ
cord-000248-zueoyesj	1338	7	export	export	NN
cord-000248-zueoyesj	1338	8	of	of	IN
cord-000248-zueoyesj	1338	9	mRNAs	mRNAs	NNPS
cord-000248-zueoyesj	1338	10	Genomic	genomic	JJ
cord-000248-zueoyesj	1338	11	structure	structure	NN
cord-000248-zueoyesj	1338	12	,	,	,
cord-000248-zueoyesj	1338	13	chromosomal	chromosomal	JJ
cord-000248-zueoyesj	1338	14	localization	localization	NN
cord-000248-zueoyesj	1338	15	and	and	CC
cord-000248-zueoyesj	1338	16	expression	expression	NN
cord-000248-zueoyesj	1338	17	profile	profile	NN
cord-000248-zueoyesj	1338	18	of	of	IN
cord-000248-zueoyesj	1338	19	a	a	DT
cord-000248-zueoyesj	1338	20	porcine	porcine	JJ
cord-000248-zueoyesj	1338	21	long	long	JJ
cord-000248-zueoyesj	1338	22	non	non	JJ
cord-000248-zueoyesj	1338	23	-	-	JJ
cord-000248-zueoyesj	1338	24	coding	coding	JJ
cord-000248-zueoyesj	1338	25	RNA	rna	NN
cord-000248-zueoyesj	1338	26	isolated	isolate	VBN
cord-000248-zueoyesj	1338	27	from	from	IN
cord-000248-zueoyesj	1338	28	long	long	JJ
cord-000248-zueoyesj	1338	29	SAGE	SAGE	NNP
cord-000248-zueoyesj	1338	30	libraries	library	NNS
cord-000248-zueoyesj	1338	31	Apoptosis	apoptosis	NN
cord-000248-zueoyesj	1338	32	,	,	,
cord-000248-zueoyesj	1338	33	cell	cell	NN
cord-000248-zueoyesj	1338	34	cycle	cycle	NN
cord-000248-zueoyesj	1338	35	progression	progression	NN
cord-000248-zueoyesj	1338	36	and	and	CC
cord-000248-zueoyesj	1338	37	gene	gene	NN
cord-000248-zueoyesj	1338	38	expression	expression	NN
cord-000248-zueoyesj	1338	39	in	in	IN
cord-000248-zueoyesj	1338	40	TP53-depleted	TP53-depleted	NNP
cord-000248-zueoyesj	1338	41	HCT116	hct116	JJ
cord-000248-zueoyesj	1338	42	colon	colon	NN
cord-000248-zueoyesj	1338	43	cancer	cancer	NN
cord-000248-zueoyesj	1338	44	cells	cell	NNS
cord-000248-zueoyesj	1338	45	in	in	IN
cord-000248-zueoyesj	1338	46	response	response	NN
cord-000248-zueoyesj	1338	47	to	to	IN
cord-000248-zueoyesj	1338	48	short	short	JJ
cord-000248-zueoyesj	1338	49	-	-	HYPH
cord-000248-zueoyesj	1338	50	term	term	NN
cord-000248-zueoyesj	1338	51	5-fluorouracil	5-fluorouracil	CD
cord-000248-zueoyesj	1338	52	treatment	treatment	NN
cord-000248-zueoyesj	1338	53	OCIA	OCIA	NNP
cord-000248-zueoyesj	1338	54	domain	domain	NN
cord-000248-zueoyesj	1338	55	containing	contain	VBG
cord-000248-zueoyesj	1338	56	2	2	CD
cord-000248-zueoyesj	1338	57	is	be	VBZ
cord-000248-zueoyesj	1338	58	highly	highly	RB
cord-000248-zueoyesj	1338	59	expressed	express	VBN
cord-000248-zueoyesj	1338	60	in	in	IN
cord-000248-zueoyesj	1338	61	adenocarcinoma	adenocarcinoma	NN
cord-000248-zueoyesj	1338	62	mixed	mixed	JJ
cord-000248-zueoyesj	1338	63	subtype	subtype	NN
cord-000248-zueoyesj	1338	64	with	with	IN
cord-000248-zueoyesj	1338	65	bronchioloalveolar	bronchioloalveolar	NNP
cord-000248-zueoyesj	1338	66	carcinoma	carcinoma	NN
cord-000248-zueoyesj	1338	67	component	component	NN
cord-000248-zueoyesj	1338	68	and	and	CC
cord-000248-zueoyesj	1338	69	is	be	VBZ
cord-000248-zueoyesj	1338	70	associated	associate	VBN
cord-000248-zueoyesj	1338	71	with	with	IN
cord-000248-zueoyesj	1338	72	better	well	JJR
cord-000248-zueoyesj	1338	73	prognosis	prognosis	NN
cord-000248-zueoyesj	1339	1	Interacting	interact	VBG
cord-000248-zueoyesj	1339	2	endogenous	endogenous	JJ
cord-000248-zueoyesj	1339	3	and	and	CC
cord-000248-zueoyesj	1339	4	exogenous	exogenous	JJ
cord-000248-zueoyesj	1339	5	RNAi	RNAi	NNS
cord-000248-zueoyesj	1339	6	pathways	pathway	NNS
cord-000248-zueoyesj	1339	7	in	in	IN
cord-000248-zueoyesj	1339	8	Caenorhabditis	Caenorhabditis	NNP
cord-000248-zueoyesj	1339	9	elegans	elegan	NNS
cord-000248-zueoyesj	1339	10	Inhibition	inhibition	NN
cord-000248-zueoyesj	1339	11	of	of	IN
cord-000248-zueoyesj	1339	12	alloresponse	alloresponse	NN
cord-000248-zueoyesj	1339	13	by	by	IN
cord-000248-zueoyesj	1339	14	a	a	DT
cord-000248-zueoyesj	1339	15	human	human	JJ
cord-000248-zueoyesj	1339	16	trophoblast	trophoblast	NN
cord-000248-zueoyesj	1339	17	non	non	JJ
cord-000248-zueoyesj	1339	18	-	-	JJ
cord-000248-zueoyesj	1339	19	coding	code	VBG
cord-000248-zueoyesj	1339	20	RNA	rna	NN
cord-000248-zueoyesj	1339	21	suppressing	suppress	VBG
cord-000248-zueoyesj	1339	22	class	class	NN
cord-000248-zueoyesj	1339	23	II	II	NNP
cord-000248-zueoyesj	1339	24	transactivator	transactivator	NN
cord-000248-zueoyesj	1339	25	promoter	promoter	NN
cord-000248-zueoyesj	1339	26	III	III	NNP
cord-000248-zueoyesj	1339	27	and	and	CC
cord-000248-zueoyesj	1339	28	major	major	JJ
cord-000248-zueoyesj	1339	29	histocompatibility	histocompatibility	NN
cord-000248-zueoyesj	1339	30	class	class	NN
cord-000248-zueoyesj	1339	31	II	ii	CD
cord-000248-zueoyesj	1339	32	expression	expression	NN
cord-000248-zueoyesj	1339	33	in	in	IN
cord-000248-zueoyesj	1339	34	murine	murine	JJ
cord-000248-zueoyesj	1339	35	Blymphocytes	Blymphocytes	NNP
cord-000248-zueoyesj	1339	36	Class	Class	NNP
cord-000248-zueoyesj	1339	37	II	II	NNP
cord-000248-zueoyesj	1339	38	transactivator	transactivator	NN
cord-000248-zueoyesj	1339	39	promoter	promoter	NN
cord-000248-zueoyesj	1339	40	activity	activity	NN
cord-000248-zueoyesj	1339	41	is	be	VBZ
cord-000248-zueoyesj	1339	42	suppressed	suppress	VBN
cord-000248-zueoyesj	1339	43	through	through	IN
cord-000248-zueoyesj	1339	44	regulation	regulation	NN
cord-000248-zueoyesj	1339	45	by	by	IN
cord-000248-zueoyesj	1339	46	a	a	DT
cord-000248-zueoyesj	1339	47	trophoblast	trophoblast	JJ
cord-000248-zueoyesj	1339	48	noncoding	noncode	VBG
cord-000248-zueoyesj	1339	49	RNA	RNA	NNP
cord-000248-zueoyesj	1339	50	MicroRNAs	MicroRNAs	NNPS
cord-000248-zueoyesj	1339	51	and	and	CC
cord-000248-zueoyesj	1339	52	other	other	JJ
cord-000248-zueoyesj	1339	53	tiny	tiny	JJ
cord-000248-zueoyesj	1339	54	endogenous	endogenous	JJ
cord-000248-zueoyesj	1339	55	RNAs	rna	NNS
cord-000248-zueoyesj	1339	56	in	in	IN
cord-000248-zueoyesj	1339	57	C.	C.	NNP
cord-000248-zueoyesj	1339	58	elegans	elegan	VBZ
cord-000248-zueoyesj	1339	59	Human	Human	NNP
cord-000248-zueoyesj	1339	60	trophoblast	trophoblast	NNP
cord-000248-zueoyesj	1339	61	noncoding	noncoding	NNP
cord-000248-zueoyesj	1339	62	RNA	RNA	NNP
cord-000248-zueoyesj	1339	63	suppresses	suppress	VBZ
cord-000248-zueoyesj	1339	64	CIITA	CIITA	NNP
cord-000248-zueoyesj	1339	65	promoter	promoter	NN
cord-000248-zueoyesj	1339	66	III	iii	CD
cord-000248-zueoyesj	1339	67	activity	activity	NN
cord-000248-zueoyesj	1339	68	in	in	IN
cord-000248-zueoyesj	1339	69	murine	murine	JJ
cord-000248-zueoyesj	1339	70	B	b	NN
cord-000248-zueoyesj	1339	71	-	-	HYPH
cord-000248-zueoyesj	1339	72	lymphocytes	lymphocyte	NNS
cord-000248-zueoyesj	1339	73	Role	role	NN
cord-000248-zueoyesj	1339	74	of	of	IN
cord-000248-zueoyesj	1339	75	human	human	JJ
cord-000248-zueoyesj	1339	76	noncoding	noncoding	JJ
cord-000248-zueoyesj	1339	77	RNAs	rna	NNS
cord-000248-zueoyesj	1339	78	in	in	IN
cord-000248-zueoyesj	1339	79	the	the	DT
cord-000248-zueoyesj	1339	80	control	control	NN
cord-000248-zueoyesj	1339	81	of	of	IN
cord-000248-zueoyesj	1339	82	tumorigenesis	tumorigenesis	NN
cord-000248-zueoyesj	1339	83	Intensive	intensive	JJ
cord-000248-zueoyesj	1339	84	entropic	entropic	JJ
cord-000248-zueoyesj	1339	85	non	non	JJ
cord-000248-zueoyesj	1339	86	-	-	JJ
cord-000248-zueoyesj	1339	87	triviality	triviality	JJ
cord-000248-zueoyesj	1339	88	measure	measure	NN
cord-000248-zueoyesj	1339	89	Statistical	statistical	JJ
cord-000248-zueoyesj	1339	90	complexity	complexity	NN
cord-000248-zueoyesj	1339	91	and	and	CC
cord-000248-zueoyesj	1339	92	disequilibrium	disequilibrium	NN
cord-000248-zueoyesj	1340	1	Distinguishing	distinguish	VBG
cord-000248-zueoyesj	1340	2	noise	noise	NN
cord-000248-zueoyesj	1340	3	from	from	IN
cord-000248-zueoyesj	1340	4	chaos	chaos	NN
cord-000248-zueoyesj	1340	5	Microarrays	Microarrays	NNP
cord-000248-zueoyesj	1340	6	-	-	HYPH
cord-000248-zueoyesj	1340	7	identifying	identify	VBG
cord-000248-zueoyesj	1340	8	molecular	molecular	JJ
cord-000248-zueoyesj	1340	9	portraits	portrait	NNS
cord-000248-zueoyesj	1340	10	for	for	IN
cord-000248-zueoyesj	1340	11	prostate	prostate	NN
cord-000248-zueoyesj	1340	12	tumors	tumor	NNS
cord-000248-zueoyesj	1340	13	with	with	IN
cord-000248-zueoyesj	1340	14	different	different	JJ
cord-000248-zueoyesj	1340	15	Gleason	Gleason	NNP
cord-000248-zueoyesj	1340	16	patterns	pattern	NNS
cord-000248-zueoyesj	1340	17	Molecular	molecular	JJ
cord-000248-zueoyesj	1340	18	portraits	portrait	NNS
cord-000248-zueoyesj	1340	19	of	of	IN
cord-000248-zueoyesj	1340	20	human	human	JJ
cord-000248-zueoyesj	1340	21	breast	breast	NN
cord-000248-zueoyesj	1340	22	tumours	tumour	NNS
cord-000248-zueoyesj	1341	1	Molecular	molecular	JJ
cord-000248-zueoyesj	1341	2	characterisation	characterisation	NN
cord-000248-zueoyesj	1341	3	of	of	IN
cord-000248-zueoyesj	1341	4	soft	soft	JJ
cord-000248-zueoyesj	1341	5	tissue	tissue	NN
cord-000248-zueoyesj	1341	6	tumours	tumour	NNS
cord-000248-zueoyesj	1341	7	:	:	:
cord-000248-zueoyesj	1342	1	a	a	DT
cord-000248-zueoyesj	1342	2	gene	gene	NN
cord-000248-zueoyesj	1342	3	expression	expression	NN
cord-000248-zueoyesj	1342	4	study	study	NN
cord-000248-zueoyesj	1342	5	Correlation	Correlation	NNP
cord-000248-zueoyesj	1342	6	Theory	Theory	NNP
cord-000248-zueoyesj	1342	7	of	of	IN
cord-000248-zueoyesj	1342	8	Statistically	statistically	RB
cord-000248-zueoyesj	1342	9	Optimal	Optimal	NNP
cord-000248-zueoyesj	1342	10	Systems	Systems	NNPS
cord-000248-zueoyesj	1342	11	Gelbaum	Gelbaum	NNP
cord-000248-zueoyesj	1342	12	BR	BR	NNP
cord-000248-zueoyesj	1342	13	Information	information	NN
cord-000248-zueoyesj	1342	14	Theory	Theory	NNP
cord-000248-zueoyesj	1342	15	,	,	,
cord-000248-zueoyesj	1342	16	Inference	inference	NN
cord-000248-zueoyesj	1342	17	,	,	,
cord-000248-zueoyesj	1342	18	and	and	CC
cord-000248-zueoyesj	1342	19	Learning	learn	VBG
cord-000248-zueoyesj	1342	20	Algorithms	Algorithms	NNP
cord-000248-zueoyesj	1343	1	A	a	DT
cord-000248-zueoyesj	1343	2	statistical	statistical	JJ
cord-000248-zueoyesj	1343	3	measure	measure	NN
cord-000248-zueoyesj	1343	4	of	of	IN
cord-000248-zueoyesj	1343	5	complexity	complexity	NN
cord-000248-zueoyesj	1343	6	Analysis	analysis	NN
cord-000248-zueoyesj	1343	7	of	of	IN
cord-000248-zueoyesj	1343	8	symbolic	symbolic	JJ
cord-000248-zueoyesj	1343	9	sequences	sequence	NNS
cord-000248-zueoyesj	1343	10	using	use	VBG
cord-000248-zueoyesj	1343	11	the	the	DT
cord-000248-zueoyesj	1343	12	Jensen	Jensen	NNP
cord-000248-zueoyesj	1343	13	-	-	HYPH
cord-000248-zueoyesj	1343	14	Shannon	Shannon	NNP
cord-000248-zueoyesj	1343	15	divergence	divergence	NN
cord-000248-zueoyesj	1343	16	Effect	effect	NN
cord-000248-zueoyesj	1343	17	of	of	IN
cord-000248-zueoyesj	1343	18	chain	chain	NN
cord-000248-zueoyesj	1343	19	length	length	NN
cord-000248-zueoyesj	1343	20	on	on	IN
cord-000248-zueoyesj	1343	21	fragility	fragility	NN
cord-000248-zueoyesj	1343	22	and	and	CC
cord-000248-zueoyesj	1343	23	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1343	24	scaling	scaling	NN
cord-000248-zueoyesj	1343	25	of	of	IN
cord-000248-zueoyesj	1343	26	the	the	DT
cord-000248-zueoyesj	1343	27	local	local	JJ
cord-000248-zueoyesj	1343	28	segmental	segmental	JJ
cord-000248-zueoyesj	1343	29	dynamics	dynamic	NNS
cord-000248-zueoyesj	1343	30	in	in	IN
cord-000248-zueoyesj	1343	31	poly(methylmethacrylate	poly(methylmethacrylate	NN
cord-000248-zueoyesj	1343	32	)	)	-RRB-
cord-000248-zueoyesj	1344	1	Length	length	NN
cord-000248-zueoyesj	1344	2	of	of	IN
cord-000248-zueoyesj	1344	3	time	time	NN
cord-000248-zueoyesj	1344	4	's	's	POS
cord-000248-zueoyesj	1344	5	arrow	arrow	NN
cord-000248-zueoyesj	1344	6	Measuring	measure	VBG
cord-000248-zueoyesj	1344	7	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1344	8	length	length	NN
cord-000248-zueoyesj	1345	1	Far	far	RB
cord-000248-zueoyesj	1345	2	-	-	HYPH
cord-000248-zueoyesj	1345	3	from	from	IN
cord-000248-zueoyesj	1345	4	-	-	HYPH
cord-000248-zueoyesj	1345	5	equilibrium	equilibrium	NN
cord-000248-zueoyesj	1345	6	measurements	measurement	NNS
cord-000248-zueoyesj	1345	7	of	of	IN
cord-000248-zueoyesj	1345	8	thermodynamic	thermodynamic	JJ
cord-000248-zueoyesj	1345	9	length	length	NN
cord-000248-zueoyesj	1345	10	Empirical	empirical	JJ
cord-000248-zueoyesj	1345	11	Relationships	Relationships	NNPS
cord-000248-zueoyesj	1345	12	between	between	IN
cord-000248-zueoyesj	1345	13	Species	Species	NNP
cord-000248-zueoyesj	1345	14	Richness	Richness	NNP
cord-000248-zueoyesj	1345	15	,	,	,
cord-000248-zueoyesj	1345	16	Evenness	evenness	NN
cord-000248-zueoyesj	1345	17	,	,	,
cord-000248-zueoyesj	1345	18	and	and	CC
cord-000248-zueoyesj	1345	19	Proportional	Proportional	NNP
cord-000248-zueoyesj	1345	20	Diversity	Diversity	NNP
cord-000248-zueoyesj	1346	1	The	the	DT
cord-000248-zueoyesj	1346	2	functional	functional	JJ
cord-000248-zueoyesj	1346	3	2443T	2443T	NNP
cord-000248-zueoyesj	1346	4	/	/	SYM
cord-000248-zueoyesj	1346	5	C	C	NNP
cord-000248-zueoyesj	1346	6	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1346	7	promoter	promoter	NN
cord-000248-zueoyesj	1346	8	polymorphism	polymorphism	NN
cord-000248-zueoyesj	1346	9	influences	influence	VBZ
cord-000248-zueoyesj	1346	10	osteopontin	osteopontin	NNP
cord-000248-zueoyesj	1346	11	gene	gene	NN
cord-000248-zueoyesj	1346	12	expression	expression	NN
cord-000248-zueoyesj	1346	13	in	in	IN
cord-000248-zueoyesj	1346	14	melanoma	melanoma	NN
cord-000248-zueoyesj	1346	15	cells	cell	NNS
cord-000248-zueoyesj	1346	16	via	via	IN
cord-000248-zueoyesj	1346	17	binding	binding	NN
cord-000248-zueoyesj	1346	18	of	of	IN
cord-000248-zueoyesj	1346	19	c	c	NNP
cord-000248-zueoyesj	1346	20	-	-	:
cord-000248-zueoyesj	1346	21	Myb	Myb	NNP
cord-000248-zueoyesj	1346	22	transcription	transcription	NN
cord-000248-zueoyesj	1346	23	factor	factor	NN
cord-000248-zueoyesj	1346	24	Tumor	tumor	NN
cord-000248-zueoyesj	1346	25	necrosis	necrosis	NN
cord-000248-zueoyesj	1346	26	is	be	VBZ
cord-000248-zueoyesj	1346	27	associated	associate	VBN
cord-000248-zueoyesj	1346	28	with	with	IN
cord-000248-zueoyesj	1346	29	increased	increase	VBN
cord-000248-zueoyesj	1346	30	alphavbeta3	alphavbeta3	NN
cord-000248-zueoyesj	1346	31	integrin	integrin	JJ
cord-000248-zueoyesj	1346	32	expression	expression	NN
cord-000248-zueoyesj	1346	33	and	and	CC
cord-000248-zueoyesj	1346	34	poor	poor	JJ
cord-000248-zueoyesj	1346	35	prognosis	prognosis	NN
cord-000248-zueoyesj	1346	36	in	in	IN
cord-000248-zueoyesj	1346	37	nodular	nodular	JJ
cord-000248-zueoyesj	1346	38	cutaneous	cutaneous	JJ
cord-000248-zueoyesj	1346	39	melanomas	melanoma	NNS
cord-000248-zueoyesj	1346	40	Osteopontin	Osteopontin	NNP
cord-000248-zueoyesj	1346	41	as	as	IN
cord-000248-zueoyesj	1346	42	a	a	DT
cord-000248-zueoyesj	1346	43	serologic	serologic	JJ
cord-000248-zueoyesj	1346	44	marker	marker	NN
cord-000248-zueoyesj	1346	45	for	for	IN
cord-000248-zueoyesj	1346	46	metastatic	metastatic	JJ
cord-000248-zueoyesj	1346	47	uveal	uveal	JJ
cord-000248-zueoyesj	1346	48	melanoma	melanoma	NN
cord-000248-zueoyesj	1346	49	:	:	:
cord-000248-zueoyesj	1346	50	results	result	NNS
cord-000248-zueoyesj	1346	51	of	of	IN
cord-000248-zueoyesj	1346	52	a	a	DT
cord-000248-zueoyesj	1346	53	pilot	pilot	NN
cord-000248-zueoyesj	1346	54	study	study	NN
cord-000248-zueoyesj	1346	55	Stable	stable	JJ
cord-000248-zueoyesj	1346	56	overexpression	overexpression	NN
cord-000248-zueoyesj	1346	57	of	of	IN
cord-000248-zueoyesj	1346	58	Smad7	Smad7	NNP
cord-000248-zueoyesj	1346	59	in	in	IN
cord-000248-zueoyesj	1346	60	human	human	JJ
cord-000248-zueoyesj	1346	61	melanoma	melanoma	NN
cord-000248-zueoyesj	1346	62	cells	cell	NNS
cord-000248-zueoyesj	1346	63	impairs	impair	VBZ
cord-000248-zueoyesj	1346	64	bone	bone	NN
cord-000248-zueoyesj	1346	65	metastasis	metastasis	NN
cord-000248-zueoyesj	1346	66	Analysis	Analysis	NNP
cord-000248-zueoyesj	1346	67	of	of	IN
cord-000248-zueoyesj	1346	68	gene	gene	NN
cord-000248-zueoyesj	1346	69	expression	expression	NN
cord-000248-zueoyesj	1346	70	in	in	IN
cord-000248-zueoyesj	1346	71	the	the	DT
cord-000248-zueoyesj	1346	72	tumor	tumor	NN
cord-000248-zueoyesj	1346	73	-	-	HYPH
cord-000248-zueoyesj	1346	74	associated	associate	VBN
cord-000248-zueoyesj	1346	75	macrophage	macrophage	NN
cord-000248-zueoyesj	1346	76	Nuclear	nuclear	JJ
cord-000248-zueoyesj	1346	77	factor	factor	NN
cord-000248-zueoyesj	1346	78	inducing	inducing	NN
cord-000248-zueoyesj	1346	79	kinase	kinase	NN
cord-000248-zueoyesj	1346	80	:	:	:
cord-000248-zueoyesj	1346	81	a	a	DT
cord-000248-zueoyesj	1346	82	key	key	JJ
cord-000248-zueoyesj	1346	83	regulator	regulator	NN
cord-000248-zueoyesj	1346	84	in	in	IN
cord-000248-zueoyesj	1346	85	osteopontin	osteopontin	NN
cord-000248-zueoyesj	1346	86	-	-	HYPH
cord-000248-zueoyesj	1346	87	induced	induce	VBN
cord-000248-zueoyesj	1346	88	MAPK	MAPK	NNP
cord-000248-zueoyesj	1346	89	/	/	SYM
cord-000248-zueoyesj	1346	90	IkappaB	IkappaB	NNP
cord-000248-zueoyesj	1346	91	kinase	kinase	VBZ
cord-000248-zueoyesj	1346	92	dependent	dependent	JJ
cord-000248-zueoyesj	1346	93	NF	nf	NN
cord-000248-zueoyesj	1346	94	-	-	HYPH
cord-000248-zueoyesj	1346	95	kappaB	kappaB	NNP
cord-000248-zueoyesj	1346	96	-	-	HYPH
cord-000248-zueoyesj	1346	97	mediated	mediate	VBN
cord-000248-zueoyesj	1346	98	promatrix	promatrix	NN
cord-000248-zueoyesj	1346	99	metalloproteinase-9	metalloproteinase-9	NNP
cord-000248-zueoyesj	1346	100	activation	activation	NN
cord-000248-zueoyesj	1347	1	Prostate	prostate	NN
cord-000248-zueoyesj	1347	2	-	-	HYPH
cord-000248-zueoyesj	1347	3	specific	specific	JJ
cord-000248-zueoyesj	1347	4	antigen	antigen	NN
cord-000248-zueoyesj	1347	5	modulates	modulate	VBZ
cord-000248-zueoyesj	1347	6	genes	gene	NNS
cord-000248-zueoyesj	1347	7	involved	involve	VBN
cord-000248-zueoyesj	1347	8	in	in	IN
cord-000248-zueoyesj	1347	9	bone	bone	NN
cord-000248-zueoyesj	1347	10	remodeling	remodeling	NN
cord-000248-zueoyesj	1347	11	and	and	CC
cord-000248-zueoyesj	1347	12	induces	induce	VBZ
cord-000248-zueoyesj	1347	13	osteoblast	osteoblast	JJ
cord-000248-zueoyesj	1347	14	differentiation	differentiation	NN
cord-000248-zueoyesj	1347	15	of	of	IN
cord-000248-zueoyesj	1347	16	human	human	JJ
cord-000248-zueoyesj	1347	17	osteosarcoma	osteosarcoma	NN
cord-000248-zueoyesj	1347	18	cell	cell	NN
cord-000248-zueoyesj	1347	19	line	line	NN
cord-000248-zueoyesj	1347	20	SaOS-2	SaOS-2	.
cord-000248-zueoyesj	1348	1	The	the	DT
cord-000248-zueoyesj	1348	2	authors	author	NNS
cord-000248-zueoyesj	1348	3	would	would	MD
cord-000248-zueoyesj	1348	4	like	like	VB
cord-000248-zueoyesj	1348	5	to	to	TO
cord-000248-zueoyesj	1348	6	thank	thank	VB
cord-000248-zueoyesj	1348	7	three	three	CD
cord-000248-zueoyesj	1348	8	Research	Research	NNP
cord-000248-zueoyesj	1348	9	Associates	Associates	NNPS
cord-000248-zueoyesj	1348	10	of	of	IN
cord-000248-zueoyesj	1348	11	our	-PRON-	PRP$
cord-000248-zueoyesj	1348	12	Centre	Centre	NNP
cord-000248-zueoyesj	1348	13	(	(	-LRB-
cord-000248-zueoyesj	1348	14	Osvaldo	Osvaldo	NNP
cord-000248-zueoyesj	1348	15	Rosso	Rosso	NNP
cord-000248-zueoyesj	1348	16	,	,	,
cord-000248-zueoyesj	1348	17	Carlos	Carlos	NNP
cord-000248-zueoyesj	1348	18	Riveros	Riveros	NNP
cord-000248-zueoyesj	1348	19	and	and	CC
cord-000248-zueoyesj	1348	20	John	John	NNP
cord-000248-zueoyesj	1348	21	Marsden	Marsden	NNP
cord-000248-zueoyesj	1348	22	)	)	-RRB-
cord-000248-zueoyesj	1348	23	for	for	IN
cord-000248-zueoyesj	1348	24	discussions	discussion	NNS
cord-000248-zueoyesj	1348	25	on	on	IN
cord-000248-zueoyesj	1348	26	this	this	DT
cord-000248-zueoyesj	1348	27	topic	topic	NN
cord-000248-zueoyesj	1348	28	.	.	.
cord-000248-zueoyesj	1349	1	We	-PRON-	PRP
cord-000248-zueoyesj	1349	2	thank	thank	VBP
cord-000248-zueoyesj	1349	3	the	the	DT
cord-000248-zueoyesj	1349	4	first	first	JJ
cord-000248-zueoyesj	1349	5	two	two	CD
cord-000248-zueoyesj	1349	6	,	,	,
cord-000248-zueoyesj	1349	7	in	in	IN
cord-000248-zueoyesj	1349	8	particular	particular	JJ
cord-000248-zueoyesj	1349	9	to	to	IN
cord-000248-zueoyesj	1349	10	Osvaldo	Osvaldo	NNP
cord-000248-zueoyesj	1349	11	,	,	,
cord-000248-zueoyesj	1349	12	for	for	IN
cord-000248-zueoyesj	1349	13	their	-PRON-	PRP$
cord-000248-zueoyesj	1349	14	collaboration	collaboration	NN
cord-000248-zueoyesj	1349	15	on	on	IN
cord-000248-zueoyesj	1349	16	data	datum	NNS
cord-000248-zueoyesj	1349	17	cleaning	cleaning	NN
cord-000248-zueoyesj	1349	18	and	and	CC
cord-000248-zueoyesj	1349	19	the	the	DT
cord-000248-zueoyesj	1349	20	computation	computation	NN
cord-000248-zueoyesj	1349	21	of	of	IN
cord-000248-zueoyesj	1349	22	the	the	DT
cord-000248-zueoyesj	1349	23	Entropy	Entropy	NNP
cord-000248-zueoyesj	1349	24	and	and	CC
cord-000248-zueoyesj	1349	25	Jensen	Jensen	NNP
cord-000248-zueoyesj	1349	26	-	-	HYPH
cord-000248-zueoyesj	1349	27	Shannon	Shannon	NNP
cord-000248-zueoyesj	1349	28	divergences	divergence	NNS
cord-000248-zueoyesj	1349	29	.	.	.
cord-000248-zueoyesj	1350	1	We	-PRON-	PRP
cord-000248-zueoyesj	1350	2	thank	thank	VBP
cord-000248-zueoyesj	1350	3	Marsden	Marsden	NNP
cord-000248-zueoyesj	1350	4	for	for	IN
cord-000248-zueoyesj	1350	5	his	-PRON-	PRP$
cord-000248-zueoyesj	1350	6	advice	advice	NN
cord-000248-zueoyesj	1350	7	on	on	IN
cord-000248-zueoyesj	1350	8	editing	edit	VBG
cord-000248-zueoyesj	1350	9	the	the	DT
cord-000248-zueoyesj	1350	10	final	final	JJ
cord-000248-zueoyesj	1350	11	draft	draft	NN
cord-000248-zueoyesj	1350	12	.	.	.
cord-000248-zueoyesj	1351	1	PM	pm	NN
cord-000248-zueoyesj	1351	2	would	would	MD
cord-000248-zueoyesj	1351	3	also	also	RB
cord-000248-zueoyesj	1351	4	like	like	VB
cord-000248-zueoyesj	1351	5	to	to	TO
cord-000248-zueoyesj	1351	6	thank	thank	VB
cord-000248-zueoyesj	1351	7	two	two	CD
cord-000248-zueoyesj	1351	8	stimulating	stimulate	VBG
cord-000248-zueoyesj	1351	9	discussions	discussion	NNS
cord-000248-zueoyesj	1351	10	(	(	-LRB-
cord-000248-zueoyesj	1351	11	decades	decade	NNS
cord-000248-zueoyesj	1351	12	apart	apart	RB
cord-000248-zueoyesj	1351	13	)	)	-RRB-
cord-000248-zueoyesj	1351	14	with	with	IN
cord-000248-zueoyesj	1351	15	Dr.	Dr.	NNP
cord-000248-zueoyesj	1351	16	Carlos	Carlos	NNP
cord-000248-zueoyesj	1351	17	Reigosa	Reigosa	NNP
cord-000248-zueoyesj	1351	18	and	and	CC
cord-000248-zueoyesj	1351	19	Prof.	Prof.	NNP
cord-000248-zueoyesj	1351	20	Elizabeth	Elizabeth	NNP
cord-000248-zueoyesj	1351	21	Blackburn	Blackburn	NNP
cord-000248-zueoyesj	1351	22	,	,	,
cord-000248-zueoyesj	1351	23	as	as	RB
cord-000248-zueoyesj	1351	24	well	well	RB
cord-000248-zueoyesj	1351	25	as	as	IN
cord-000248-zueoyesj	1351	26	the	the	DT
cord-000248-zueoyesj	1351	27	invisible	invisible	JJ
cord-000248-zueoyesj	1351	28	hand	hand	NN
cord-000248-zueoyesj	1351	29	of	of	IN
cord-000248-zueoyesj	1351	30	Prof.	Prof.	NNP
cord-000248-zueoyesj	1351	31	Yaser	Yaser	NNP
cord-000248-zueoyesj	1351	32	Abu	Abu	NNP
cord-000248-zueoyesj	1351	33	-	-	HYPH
cord-000248-zueoyesj	1351	34	Mostafa	Mostafa	NNP
cord-000248-zueoyesj	1351	35	.	.	.
cord-000248-zueoyesj	1351	36	 	 	_SP