id	sid	tid	token	lemma	pos
cord-000180-howix091	1	1	key	key	JJ
cord-000180-howix091	1	2	:	:	:
cord-000180-howix091	1	3	cord-000180-howix091	cord-000180-howix091	NNP
cord-000180-howix091	1	4	authors	author	NNS
cord-000180-howix091	1	5	:	:	:
cord-000180-howix091	1	6	MacLeod	MacLeod	NNP
cord-000180-howix091	1	7	,	,	,
cord-000180-howix091	1	8	Iain	Iain	NNP
cord-000180-howix091	1	9	J.	J.	NNP
cord-000180-howix091	1	10	;	;	:
cord-000180-howix091	1	11	Minson	Minson	NNP
cord-000180-howix091	1	12	,	,	,
cord-000180-howix091	2	1	Tony	tony	JJ
cord-000180-howix091	2	2	title	title	NN
cord-000180-howix091	2	3	:	:	:
cord-000180-howix091	3	1	Binding	bind	VBG
cord-000180-howix091	3	2	of	of	IN
cord-000180-howix091	3	3	Herpes	Herpes	NNP
cord-000180-howix091	3	4	Simplex	Simplex	NNP
cord-000180-howix091	3	5	Virus	Virus	NNP
cord-000180-howix091	3	6	Type-1	type-1	NN
cord-000180-howix091	3	7	Virions	Virions	NNP
cord-000180-howix091	3	8	Leads	lead	VBZ
cord-000180-howix091	3	9	to	to	IN
cord-000180-howix091	3	10	the	the	DT
cord-000180-howix091	3	11	Induction	Induction	NNP
cord-000180-howix091	3	12	of	of	IN
cord-000180-howix091	3	13	Intracellular	Intracellular	NNP
cord-000180-howix091	3	14	Signalling	signal	VBG
cord-000180-howix091	3	15	in	in	IN
cord-000180-howix091	3	16	the	the	DT
cord-000180-howix091	3	17	Absence	absence	NN
cord-000180-howix091	3	18	of	of	IN
cord-000180-howix091	3	19	Virus	Virus	NNP
cord-000180-howix091	3	20	Entry	Entry	NNP
cord-000180-howix091	3	21	date	date	NN
cord-000180-howix091	3	22	:	:	:
cord-000180-howix091	3	23	2010	2010	CD
cord-000180-howix091	3	24	-	-	SYM
cord-000180-howix091	3	25	03	03	CD
cord-000180-howix091	3	26	-	-	HYPH
cord-000180-howix091	3	27	05	05	CD
cord-000180-howix091	3	28	journal	journal	NN
cord-000180-howix091	3	29	:	:	:
cord-000180-howix091	4	1	PLoS	PLoS	NNP
cord-000180-howix091	4	2	One	one	CD
cord-000180-howix091	4	3	DOI	doi	NN
cord-000180-howix091	4	4	:	:	:
cord-000180-howix091	5	1	10.1371	10.1371	CD
cord-000180-howix091	5	2	/	/	SYM
cord-000180-howix091	5	3	journal.pone.0009560	journal.pone.0009560	NN
cord-000180-howix091	5	4	sha	sha	NNP
cord-000180-howix091	5	5	:	:	:
cord-000180-howix091	5	6	f72764a9a0f911eb892cf04752566d6ef4ee54c4	f72764a9a0f911eb892cf04752566d6ef4ee54c4	XX
cord-000180-howix091	5	7	doc_id	doc_id	CD
cord-000180-howix091	5	8	:	:	:
cord-000180-howix091	5	9	180	180	CD
cord-000180-howix091	5	10	cord_uid	cord_uid	NNS
cord-000180-howix091	5	11	:	:	:
cord-000180-howix091	5	12	howix091	howix091	NNP
cord-000180-howix091	6	1	The	the	DT
cord-000180-howix091	6	2	envelope	envelope	NN
cord-000180-howix091	6	3	of	of	IN
cord-000180-howix091	6	4	HSV-1	hsv-1	NN
cord-000180-howix091	6	5	contains	contain	VBZ
cord-000180-howix091	6	6	a	a	DT
cord-000180-howix091	6	7	number	number	NN
cord-000180-howix091	6	8	of	of	IN
cord-000180-howix091	6	9	glycoproteins	glycoprotein	NNS
cord-000180-howix091	6	10	,	,	,
cord-000180-howix091	6	11	four	four	CD
cord-000180-howix091	6	12	of	of	IN
cord-000180-howix091	6	13	which	which	WDT
cord-000180-howix091	6	14	are	be	VBP
cord-000180-howix091	6	15	essential	essential	JJ
cord-000180-howix091	6	16	for	for	IN
cord-000180-howix091	6	17	virus	virus	NN
cord-000180-howix091	6	18	entry	entry	NN
cord-000180-howix091	6	19	.	.	.
cord-000180-howix091	7	1	Virus	virus	NN
cord-000180-howix091	7	2	particles	particle	NNS
cord-000180-howix091	7	3	lacking	lack	VBG
cord-000180-howix091	7	4	gB	gB	NNP
cord-000180-howix091	7	5	,	,	,
cord-000180-howix091	7	6	gD	gD	NNP
cord-000180-howix091	7	7	,	,	,
cord-000180-howix091	8	1	gH	gH	NNP
cord-000180-howix091	8	2	or	or	CC
cord-000180-howix091	8	3	gL	gl	NN
cord-000180-howix091	8	4	are	be	VBP
cord-000180-howix091	8	5	entry	entry	NN
cord-000180-howix091	8	6	-	-	HYPH
cord-000180-howix091	8	7	defective	defective	JJ
cord-000180-howix091	8	8	,	,	,
cord-000180-howix091	8	9	although	although	IN
cord-000180-howix091	8	10	these	these	DT
cord-000180-howix091	8	11	viruses	virus	NNS
cord-000180-howix091	8	12	retain	retain	VBP
cord-000180-howix091	8	13	the	the	DT
cord-000180-howix091	8	14	ability	ability	NN
cord-000180-howix091	8	15	to	to	TO
cord-000180-howix091	8	16	bind	bind	VB
cord-000180-howix091	8	17	to	to	IN
cord-000180-howix091	8	18	the	the	DT
cord-000180-howix091	8	19	plasma	plasma	NN
cord-000180-howix091	8	20	membrane	membrane	NN
cord-000180-howix091	8	21	via	via	IN
cord-000180-howix091	8	22	the	the	DT
cord-000180-howix091	8	23	remaining	remain	VBG
cord-000180-howix091	8	24	glycoproteins	glycoprotein	NNS
cord-000180-howix091	8	25	.	.	.
cord-000180-howix091	9	1	Soluble	soluble	JJ
cord-000180-howix091	9	2	forms	form	NNS
cord-000180-howix091	9	3	of	of	IN
cord-000180-howix091	9	4	gD	gd	CD
cord-000180-howix091	9	5	have	have	VBP
cord-000180-howix091	9	6	been	be	VBN
cord-000180-howix091	9	7	shown	show	VBN
cord-000180-howix091	9	8	to	to	TO
cord-000180-howix091	9	9	trigger	trigger	VB
cord-000180-howix091	9	10	the	the	DT
cord-000180-howix091	9	11	nuclear	nuclear	JJ
cord-000180-howix091	9	12	translocation	translocation	NN
cord-000180-howix091	9	13	of	of	IN
cord-000180-howix091	9	14	the	the	DT
cord-000180-howix091	9	15	NF	nf	NN
cord-000180-howix091	9	16	-	-	HYPH
cord-000180-howix091	9	17	κB	κb	CD
cord-000180-howix091	9	18	transcriptional	transcriptional	JJ
cord-000180-howix091	9	19	complex	complex	NN
cord-000180-howix091	9	20	in	in	IN
cord-000180-howix091	9	21	addition	addition	NN
cord-000180-howix091	9	22	to	to	IN
cord-000180-howix091	9	23	stimulating	stimulate	VBG
cord-000180-howix091	9	24	the	the	DT
cord-000180-howix091	9	25	production	production	NN
cord-000180-howix091	9	26	of	of	IN
cord-000180-howix091	9	27	Type	type	NN
cord-000180-howix091	9	28	I	-PRON-	PRP
cord-000180-howix091	9	29	interferon	interferon	VBD
cord-000180-howix091	9	30	.	.	.
cord-000180-howix091	10	1	By	by	IN
cord-000180-howix091	10	2	taking	take	VBG
cord-000180-howix091	10	3	advantage	advantage	NN
cord-000180-howix091	10	4	of	of	IN
cord-000180-howix091	10	5	the	the	DT
cord-000180-howix091	10	6	entry	entry	NN
cord-000180-howix091	10	7	-	-	HYPH
cord-000180-howix091	10	8	defective	defective	JJ
cord-000180-howix091	10	9	phenotype	phenotype	NN
cord-000180-howix091	10	10	of	of	IN
cord-000180-howix091	10	11	glycoprotein	glycoprotein	NN
cord-000180-howix091	10	12	-	-	HYPH
cord-000180-howix091	10	13	deficient	deficient	JJ
cord-000180-howix091	10	14	HSV-1	hsv-1	NN
cord-000180-howix091	10	15	virus	virus	NN
cord-000180-howix091	10	16	particles	particle	NNS
cord-000180-howix091	10	17	,	,	,
cord-000180-howix091	10	18	the	the	DT
cord-000180-howix091	10	19	results	result	NNS
cord-000180-howix091	10	20	presented	present	VBN
cord-000180-howix091	10	21	here	here	RB
cord-000180-howix091	10	22	show	show	VBP
cord-000180-howix091	10	23	that	that	IN
cord-000180-howix091	10	24	binding	binding	NN
cord-000180-howix091	10	25	of	of	IN
cord-000180-howix091	10	26	virions	virion	NNS
cord-000180-howix091	10	27	to	to	IN
cord-000180-howix091	10	28	cellular	cellular	JJ
cord-000180-howix091	10	29	receptors	receptor	NNS
cord-000180-howix091	10	30	on	on	IN
cord-000180-howix091	10	31	the	the	DT
cord-000180-howix091	10	32	plasma	plasma	NN
cord-000180-howix091	10	33	membrane	membrane	NN
cord-000180-howix091	10	34	is	be	VBZ
cord-000180-howix091	10	35	sufficient	sufficient	JJ
cord-000180-howix091	10	36	to	to	TO
cord-000180-howix091	10	37	stimulate	stimulate	VB
cord-000180-howix091	10	38	a	a	DT
cord-000180-howix091	10	39	change	change	NN
cord-000180-howix091	10	40	in	in	IN
cord-000180-howix091	10	41	cellular	cellular	JJ
cord-000180-howix091	10	42	gene	gene	NN
cord-000180-howix091	10	43	expression	expression	NN
cord-000180-howix091	10	44	.	.	.
cord-000180-howix091	11	1	Preliminary	preliminary	JJ
cord-000180-howix091	11	2	microarray	microarray	NN
cord-000180-howix091	11	3	studies	study	NNS
cord-000180-howix091	11	4	,	,	,
cord-000180-howix091	11	5	validated	validate	VBN
cord-000180-howix091	11	6	by	by	IN
cord-000180-howix091	11	7	quantitative	quantitative	JJ
cord-000180-howix091	11	8	real	real	JJ
cord-000180-howix091	11	9	-	-	HYPH
cord-000180-howix091	11	10	time	time	NN
cord-000180-howix091	11	11	PCR	PCR	NNP
cord-000180-howix091	11	12	,	,	,
cord-000180-howix091	11	13	identified	identify	VBD
cord-000180-howix091	11	14	the	the	DT
cord-000180-howix091	11	15	differential	differential	JJ
cord-000180-howix091	11	16	expression	expression	NN
cord-000180-howix091	11	17	of	of	IN
cord-000180-howix091	11	18	cellular	cellular	JJ
cord-000180-howix091	11	19	genes	gene	NNS
cord-000180-howix091	11	20	associated	associate	VBN
cord-000180-howix091	11	21	with	with	IN
cord-000180-howix091	11	22	the	the	DT
cord-000180-howix091	11	23	NF	nf	NN
cord-000180-howix091	11	24	-	-	HYPH
cord-000180-howix091	11	25	κB	κB	NNP
cord-000180-howix091	11	26	,	,	,
cord-000180-howix091	12	1	PI3K	PI3K	NNP
cord-000180-howix091	12	2	/	/	SYM
cord-000180-howix091	12	3	Akt	Akt	NNP
cord-000180-howix091	12	4	,	,	,
cord-000180-howix091	12	5	Jak	Jak	NNP
cord-000180-howix091	12	6	/	/	SYM
cord-000180-howix091	12	7	Stat	Stat	NNP
cord-000180-howix091	12	8	and	and	CC
cord-000180-howix091	12	9	related	relate	VBN
cord-000180-howix091	12	10	Jak	Jak	NNP
cord-000180-howix091	12	11	/	/	SYM
cord-000180-howix091	12	12	Src	Src	NNP
cord-000180-howix091	12	13	pathways	pathway	NNS
cord-000180-howix091	12	14	by	by	IN
cord-000180-howix091	12	15	virions	virion	NNS
cord-000180-howix091	12	16	lacking	lack	VBG
cord-000180-howix091	12	17	gB	gB	NNP
cord-000180-howix091	12	18	or	or	CC
cord-000180-howix091	12	19	gH	gh	NN
cord-000180-howix091	12	20	but	but	CC
cord-000180-howix091	12	21	not	not	RB
cord-000180-howix091	12	22	gD.	gd.	NN
cord-000180-howix091	12	23	Gene	Gene	NNP
cord-000180-howix091	12	24	induction	induction	NN
cord-000180-howix091	12	25	occurred	occur	VBD
cord-000180-howix091	12	26	at	at	IN
cord-000180-howix091	12	27	a	a	DT
cord-000180-howix091	12	28	few	few	JJ
cord-000180-howix091	12	29	particles	particle	NNS
cord-000180-howix091	12	30	per	per	IN
cord-000180-howix091	12	31	cell	cell	NN
cord-000180-howix091	12	32	,	,	,
cord-000180-howix091	12	33	corresponding	correspond	VBG
cord-000180-howix091	12	34	to	to	IN
cord-000180-howix091	12	35	physiological	physiological	JJ
cord-000180-howix091	12	36	conditions	condition	NNS
cord-000180-howix091	12	37	during	during	IN
cord-000180-howix091	12	38	primary	primary	JJ
cord-000180-howix091	12	39	infection	infection	NN
cord-000180-howix091	12	40	.	.	.
cord-000180-howix091	13	1	Reporter	reporter	NN
cord-000180-howix091	13	2	assay	assay	NN
cord-000180-howix091	13	3	studies	study	NNS
cord-000180-howix091	13	4	determined	determine	VBD
cord-000180-howix091	13	5	that	that	IN
cord-000180-howix091	13	6	NF	nf	NN
cord-000180-howix091	13	7	-	-	HYPH
cord-000180-howix091	13	8	κB	κb	CD
cord-000180-howix091	13	9	transcriptional	transcriptional	JJ
cord-000180-howix091	13	10	activity	activity	NN
cord-000180-howix091	13	11	is	be	VBZ
cord-000180-howix091	13	12	stimulated	stimulate	VBN
cord-000180-howix091	13	13	within	within	IN
cord-000180-howix091	13	14	an	an	DT
cord-000180-howix091	13	15	hour	hour	NN
cord-000180-howix091	13	16	of	of	IN
cord-000180-howix091	13	17	HSV-1	hsv-1	NN
cord-000180-howix091	13	18	binding	bind	VBG
cord-000180-howix091	13	19	,	,	,
cord-000180-howix091	13	20	peaks	peak	NNS
cord-000180-howix091	13	21	between	between	IN
cord-000180-howix091	13	22	two	two	CD
cord-000180-howix091	13	23	and	and	CC
cord-000180-howix091	13	24	three	three	CD
cord-000180-howix091	13	25	hours	hour	NNS
cord-000180-howix091	13	26	post	post	NN
cord-000180-howix091	13	27	-	-	JJ
cord-000180-howix091	13	28	binding	binding	JJ
cord-000180-howix091	13	29	and	and	CC
cord-000180-howix091	13	30	declines	decline	VBZ
cord-000180-howix091	13	31	to	to	TO
cord-000180-howix091	13	32	background	background	NN
cord-000180-howix091	13	33	levels	level	NNS
cord-000180-howix091	13	34	by	by	IN
cord-000180-howix091	13	35	five	five	CD
cord-000180-howix091	13	36	hours	hour	NNS
cord-000180-howix091	13	37	after	after	IN
cord-000180-howix091	13	38	induction	induction	NN
cord-000180-howix091	13	39	.	.	.
cord-000180-howix091	14	1	The	the	DT
cord-000180-howix091	14	2	immediate	immediate	JJ
cord-000180-howix091	14	3	,	,	,
cord-000180-howix091	14	4	transient	transient	JJ
cord-000180-howix091	14	5	nature	nature	NN
cord-000180-howix091	14	6	of	of	IN
cord-000180-howix091	14	7	these	these	DT
cord-000180-howix091	14	8	signalling	signal	VBG
cord-000180-howix091	14	9	events	event	NNS
cord-000180-howix091	14	10	suggests	suggest	VBZ
cord-000180-howix091	14	11	that	that	IN
cord-000180-howix091	14	12	HSV-1	hsv-1	NN
cord-000180-howix091	14	13	glycoproteins	glycoprotein	NNS
cord-000180-howix091	14	14	,	,	,
cord-000180-howix091	14	15	particularly	particularly	RB
cord-000180-howix091	14	16	gD	gD	NNP
cord-000180-howix091	14	17	,	,	,
cord-000180-howix091	14	18	may	may	MD
cord-000180-howix091	14	19	alter	alter	VB
cord-000180-howix091	14	20	the	the	DT
cord-000180-howix091	14	21	cellular	cellular	JJ
cord-000180-howix091	14	22	environment	environment	NN
cord-000180-howix091	14	23	pre	pre	NN
cord-000180-howix091	14	24	-	-	NN
cord-000180-howix091	14	25	entry	entry	NN
cord-000180-howix091	14	26	so	so	IN
cord-000180-howix091	14	27	as	as	IN
cord-000180-howix091	14	28	to	to	TO
cord-000180-howix091	14	29	condition	condition	VB
cord-000180-howix091	14	30	the	the	DT
cord-000180-howix091	14	31	cell	cell	NN
cord-000180-howix091	14	32	for	for	IN
cord-000180-howix091	14	33	viral	viral	JJ
cord-000180-howix091	14	34	replication	replication	NN
cord-000180-howix091	14	35	.	.	.
cord-000180-howix091	15	1	Subjugation	subjugation	NN
cord-000180-howix091	15	2	of	of	IN
cord-000180-howix091	15	3	the	the	DT
cord-000180-howix091	15	4	intracellular	intracellular	JJ
cord-000180-howix091	15	5	environment	environment	NN
cord-000180-howix091	15	6	by	by	IN
cord-000180-howix091	15	7	viruses	virus	NNS
cord-000180-howix091	15	8	is	be	VBZ
cord-000180-howix091	15	9	essential	essential	JJ
cord-000180-howix091	15	10	to	to	TO
cord-000180-howix091	15	11	ensure	ensure	VB
cord-000180-howix091	15	12	the	the	DT
cord-000180-howix091	15	13	effective	effective	JJ
cord-000180-howix091	15	14	expression	expression	NN
cord-000180-howix091	15	15	and	and	CC
cord-000180-howix091	15	16	replication	replication	NN
cord-000180-howix091	15	17	of	of	IN
cord-000180-howix091	15	18	the	the	DT
cord-000180-howix091	15	19	viral	viral	JJ
cord-000180-howix091	15	20	genome	genome	NN
cord-000180-howix091	15	21	to	to	TO
cord-000180-howix091	15	22	allow	allow	VB
cord-000180-howix091	15	23	production	production	NN
cord-000180-howix091	15	24	of	of	IN
cord-000180-howix091	15	25	progeny	progeny	JJ
cord-000180-howix091	15	26	virions	virion	NNS
cord-000180-howix091	15	27	.	.	.
cord-000180-howix091	16	1	One	one	CD
cord-000180-howix091	16	2	such	such	JJ
cord-000180-howix091	16	3	viral	viral	JJ
cord-000180-howix091	16	4	strategy	strategy	NN
cord-000180-howix091	16	5	involves	involve	VBZ
cord-000180-howix091	16	6	hijacking	hijack	VBG
cord-000180-howix091	16	7	signalling	signal	VBG
cord-000180-howix091	16	8	pathways	pathway	NNS
cord-000180-howix091	16	9	that	that	WDT
cord-000180-howix091	16	10	ultimately	ultimately	RB
cord-000180-howix091	16	11	control	control	VBP
cord-000180-howix091	16	12	host	host	NN
cord-000180-howix091	16	13	gene	gene	NN
cord-000180-howix091	16	14	transcription	transcription	NN
cord-000180-howix091	16	15	.	.	.
cord-000180-howix091	17	1	Interactions	interaction	NNS
cord-000180-howix091	17	2	between	between	IN
cord-000180-howix091	17	3	intracellular	intracellular	JJ
cord-000180-howix091	17	4	viral	viral	JJ
cord-000180-howix091	17	5	proteins	protein	NNS
cord-000180-howix091	17	6	and	and	CC
cord-000180-howix091	17	7	cellular	cellular	JJ
cord-000180-howix091	17	8	kinases	kinase	NNS
cord-000180-howix091	17	9	responsible	responsible	JJ
cord-000180-howix091	17	10	for	for	IN
cord-000180-howix091	17	11	signal	signal	NN
cord-000180-howix091	17	12	transduction	transduction	NN
cord-000180-howix091	17	13	are	be	VBP
cord-000180-howix091	17	14	a	a	DT
cord-000180-howix091	17	15	means	means	NN
cord-000180-howix091	17	16	by	by	IN
cord-000180-howix091	17	17	which	which	WDT
cord-000180-howix091	17	18	to	to	TO
cord-000180-howix091	17	19	achieve	achieve	VB
cord-000180-howix091	17	20	this	this	DT
cord-000180-howix091	17	21	.	.	.
cord-000180-howix091	18	1	However	however	RB
cord-000180-howix091	18	2	,	,	,
cord-000180-howix091	18	3	there	there	EX
cord-000180-howix091	18	4	is	be	VBZ
cord-000180-howix091	18	5	growing	grow	VBG
cord-000180-howix091	18	6	evidence	evidence	NN
cord-000180-howix091	18	7	to	to	TO
cord-000180-howix091	18	8	support	support	VB
cord-000180-howix091	18	9	the	the	DT
cord-000180-howix091	18	10	premise	premise	NN
cord-000180-howix091	18	11	that	that	IN
cord-000180-howix091	18	12	glycoproteins	glycoprotein	NNS
cord-000180-howix091	18	13	on	on	IN
cord-000180-howix091	18	14	the	the	DT
cord-000180-howix091	18	15	surface	surface	NN
cord-000180-howix091	18	16	of	of	IN
cord-000180-howix091	18	17	virus	virus	NN
cord-000180-howix091	18	18	particles	particle	NNS
cord-000180-howix091	18	19	may	may	MD
cord-000180-howix091	18	20	trigger	trigger	VB
cord-000180-howix091	18	21	intracellular	intracellular	JJ
cord-000180-howix091	18	22	signalling	signal	VBG
cord-000180-howix091	18	23	pathways	pathway	NNS
cord-000180-howix091	18	24	by	by	IN
cord-000180-howix091	18	25	interacting	interact	VBG
cord-000180-howix091	18	26	with	with	IN
cord-000180-howix091	18	27	their	-PRON-	PRP$
cord-000180-howix091	18	28	cognate	cognate	JJ
cord-000180-howix091	18	29	receptors	receptor	NNS
cord-000180-howix091	18	30	on	on	IN
cord-000180-howix091	18	31	the	the	DT
cord-000180-howix091	18	32	host	host	NN
cord-000180-howix091	18	33	cell	cell	NN
cord-000180-howix091	18	34	membrane	membrane	NN
cord-000180-howix091	18	35	[	[	-LRB-
cord-000180-howix091	18	36	1	1	CD
cord-000180-howix091	18	37	]	]	-RRB-
cord-000180-howix091	18	38	.	.	.
cord-000180-howix091	19	1	Binding	bind	VBG
cord-000180-howix091	19	2	of	of	IN
cord-000180-howix091	19	3	HSV-1	hsv-1	NN
cord-000180-howix091	19	4	to	to	IN
cord-000180-howix091	19	5	permissive	permissive	JJ
cord-000180-howix091	19	6	cells	cell	NNS
cord-000180-howix091	19	7	occurs	occur	VBZ
cord-000180-howix091	19	8	through	through	IN
cord-000180-howix091	19	9	viral	viral	JJ
cord-000180-howix091	19	10	glycoproteins	glycoprotein	NNS
cord-000180-howix091	19	11	on	on	IN
cord-000180-howix091	19	12	the	the	DT
cord-000180-howix091	19	13	viral	viral	JJ
cord-000180-howix091	19	14	envelope	envelope	NN
cord-000180-howix091	19	15	interacting	interact	VBG
cord-000180-howix091	19	16	with	with	IN
cord-000180-howix091	19	17	specific	specific	JJ
cord-000180-howix091	19	18	receptors	receptor	NNS
cord-000180-howix091	19	19	on	on	IN
cord-000180-howix091	19	20	the	the	DT
cord-000180-howix091	19	21	cell	cell	NN
cord-000180-howix091	19	22	surface	surface	NN
cord-000180-howix091	19	23	,	,	,
cord-000180-howix091	19	24	triggering	trigger	VBG
cord-000180-howix091	19	25	fusion	fusion	NN
cord-000180-howix091	19	26	of	of	IN
cord-000180-howix091	19	27	the	the	DT
cord-000180-howix091	19	28	plasma	plasma	NN
cord-000180-howix091	19	29	membrane	membrane	NN
cord-000180-howix091	19	30	with	with	IN
cord-000180-howix091	19	31	the	the	DT
cord-000180-howix091	19	32	outer	outer	JJ
cord-000180-howix091	19	33	envelope	envelope	NN
cord-000180-howix091	19	34	.	.	.
cord-000180-howix091	20	1	Five	five	CD
cord-000180-howix091	20	2	of	of	IN
cord-000180-howix091	20	3	these	these	DT
cord-000180-howix091	20	4	glycoproteins	glycoprotein	NNS
cord-000180-howix091	20	5	are	be	VBP
cord-000180-howix091	20	6	known	know	VBN
cord-000180-howix091	20	7	to	to	TO
cord-000180-howix091	20	8	be	be	VB
cord-000180-howix091	20	9	involved	involve	VBN
cord-000180-howix091	20	10	in	in	IN
cord-000180-howix091	20	11	virion	virion	NN
cord-000180-howix091	20	12	binding	bind	VBG
cord-000180-howix091	20	13	to	to	IN
cord-000180-howix091	20	14	the	the	DT
cord-000180-howix091	20	15	cell	cell	NN
cord-000180-howix091	20	16	surface	surface	NN
cord-000180-howix091	20	17	:	:	:
cord-000180-howix091	20	18	gB	gB	NNP
cord-000180-howix091	20	19	,	,	,
cord-000180-howix091	20	20	gC	gc	NN
cord-000180-howix091	20	21	,	,	,
cord-000180-howix091	20	22	gD	gD	NNP
cord-000180-howix091	20	23	and	and	CC
cord-000180-howix091	20	24	the	the	DT
cord-000180-howix091	20	25	heterodimer	heterodimer	NN
cord-000180-howix091	20	26	gH	gH	NNP
cord-000180-howix091	20	27	-	-	HYPH
cord-000180-howix091	20	28	L.	L.	NNP
cord-000180-howix091	21	1	Of	of	IN
cord-000180-howix091	21	2	the	the	DT
cord-000180-howix091	21	3	five	five	CD
cord-000180-howix091	21	4	,	,	,
cord-000180-howix091	21	5	only	only	RB
cord-000180-howix091	21	6	gC	gC	NNP
cord-000180-howix091	21	7	is	be	VBZ
cord-000180-howix091	21	8	dispensable	dispensable	JJ
cord-000180-howix091	21	9	for	for	IN
cord-000180-howix091	21	10	allowing	allow	VBG
cord-000180-howix091	21	11	productive	productive	JJ
cord-000180-howix091	21	12	infection	infection	NN
cord-000180-howix091	21	13	as	as	IN
cord-000180-howix091	21	14	deletion	deletion	NN
cord-000180-howix091	21	15	of	of	IN
cord-000180-howix091	21	16	gB	gB	NNP
cord-000180-howix091	21	17	,	,	,
cord-000180-howix091	21	18	gD	gD	NNP
cord-000180-howix091	21	19	or	or	CC
cord-000180-howix091	21	20	gH	gh	NN
cord-000180-howix091	21	21	-	-	HYPH
cord-000180-howix091	21	22	L	l	NN
cord-000180-howix091	21	23	results	result	NNS
cord-000180-howix091	21	24	in	in	IN
cord-000180-howix091	21	25	an	an	DT
cord-000180-howix091	21	26	entry	entry	NN
cord-000180-howix091	21	27	-	-	HYPH
cord-000180-howix091	21	28	defective	defective	JJ
cord-000180-howix091	21	29	phenotype	phenotype	NN
cord-000180-howix091	21	30	[	[	-LRB-
cord-000180-howix091	21	31	2	2	CD
cord-000180-howix091	21	32	]	]	-RRB-
cord-000180-howix091	21	33	[	[	-LRB-
cord-000180-howix091	21	34	3	3	CD
cord-000180-howix091	21	35	]	]	-RRB-
cord-000180-howix091	21	36	.	.	.
cord-000180-howix091	22	1	gD	gD	NNP
cord-000180-howix091	22	2	is	be	VBZ
cord-000180-howix091	22	3	known	know	VBN
cord-000180-howix091	22	4	to	to	TO
cord-000180-howix091	22	5	bind	bind	VB
cord-000180-howix091	22	6	independently	independently	RB
cord-000180-howix091	22	7	to	to	IN
cord-000180-howix091	22	8	HvEM	HvEM	NNP
cord-000180-howix091	22	9	,	,	,
cord-000180-howix091	22	10	nectin-1	nectin-1	NNP
cord-000180-howix091	22	11	and	and	CC
cord-000180-howix091	22	12	nectin-2	nectin-2	NNP
cord-000180-howix091	22	13	,	,	,
cord-000180-howix091	22	14	whereas	whereas	IN
cord-000180-howix091	22	15	gH	gH	NNP
cord-000180-howix091	22	16	interacts	interact	VBZ
cord-000180-howix091	22	17	with	with	IN
cord-000180-howix091	22	18	the	the	DT
cord-000180-howix091	22	19	avb3	avb3	NN
cord-000180-howix091	22	20	integrin	integrin	NN
cord-000180-howix091	22	21	,	,	,
cord-000180-howix091	22	22	with	with	IN
cord-000180-howix091	22	23	the	the	DT
cord-000180-howix091	22	24	paired	pair	VBN
cord-000180-howix091	22	25	immunoglobulin	immunoglobulin	NN
cord-000180-howix091	22	26	-	-	HYPH
cord-000180-howix091	22	27	like	like	JJ
cord-000180-howix091	22	28	receptor	receptor	NN
cord-000180-howix091	22	29	,	,	,
cord-000180-howix091	22	30	PILRa	PILRa	NNP
cord-000180-howix091	22	31	,	,	,
cord-000180-howix091	22	32	acting	act	VBG
cord-000180-howix091	22	33	as	as	IN
cord-000180-howix091	22	34	a	a	DT
cord-000180-howix091	22	35	receptor	receptor	NN
cord-000180-howix091	22	36	for	for	IN
cord-000180-howix091	22	37	gB	gB	NNP
cord-000180-howix091	22	38	[	[	-LRB-
cord-000180-howix091	22	39	2	2	CD
cord-000180-howix091	22	40	]	]	-RRB-
cord-000180-howix091	22	41	[	[	-LRB-
cord-000180-howix091	22	42	4	4	CD
cord-000180-howix091	22	43	]	]	-RRB-
cord-000180-howix091	22	44	[	[	-LRB-
cord-000180-howix091	22	45	5	5	CD
cord-000180-howix091	22	46	]	]	-RRB-
cord-000180-howix091	22	47	.	.	.
cord-000180-howix091	23	1	One	one	CD
cord-000180-howix091	23	2	of	of	IN
cord-000180-howix091	23	3	the	the	DT
cord-000180-howix091	23	4	first	first	JJ
cord-000180-howix091	23	5	studies	study	NNS
cord-000180-howix091	23	6	to	to	TO
cord-000180-howix091	23	7	examine	examine	VB
cord-000180-howix091	23	8	whether	whether	IN
cord-000180-howix091	23	9	HSV-1	hsv-1	NN
cord-000180-howix091	23	10	glycoproteins	glycoprotein	NNS
cord-000180-howix091	23	11	play	play	VBP
cord-000180-howix091	23	12	a	a	DT
cord-000180-howix091	23	13	role	role	NN
cord-000180-howix091	23	14	in	in	IN
cord-000180-howix091	23	15	the	the	DT
cord-000180-howix091	23	16	induction	induction	NN
cord-000180-howix091	23	17	of	of	IN
cord-000180-howix091	23	18	signalling	signal	VBG
cord-000180-howix091	23	19	found	find	VBD
cord-000180-howix091	23	20	that	that	IN
cord-000180-howix091	23	21	gD	gD	NNP
cord-000180-howix091	23	22	was	be	VBD
cord-000180-howix091	23	23	able	able	JJ
cord-000180-howix091	23	24	to	to	TO
cord-000180-howix091	23	25	block	block	VB
cord-000180-howix091	23	26	Fas	Fas	NNP
cord-000180-howix091	23	27	-	-	HYPH
cord-000180-howix091	23	28	mediated	mediate	VBN
cord-000180-howix091	23	29	apoptosis	apoptosis	NN
cord-000180-howix091	23	30	[	[	-LRB-
cord-000180-howix091	23	31	6	6	CD
cord-000180-howix091	23	32	]	]	-RRB-
cord-000180-howix091	23	33	.	.	.
cord-000180-howix091	24	1	U937	U937	NNP
cord-000180-howix091	24	2	monocytoid	monocytoid	NN
cord-000180-howix091	24	3	cells	cell	NNS
cord-000180-howix091	24	4	were	be	VBD
cord-000180-howix091	24	5	rendered	render	VBN
cord-000180-howix091	24	6	resistant	resistant	JJ
cord-000180-howix091	24	7	to	to	IN
cord-000180-howix091	24	8	apoptosis	apoptosis	NN
cord-000180-howix091	24	9	after	after	IN
cord-000180-howix091	24	10	infection	infection	NN
cord-000180-howix091	24	11	with	with	IN
cord-000180-howix091	24	12	UVinactivated	uvinactivated	JJ
cord-000180-howix091	24	13	HSV	HSV	NNP
cord-000180-howix091	24	14	virions	virion	NNS
cord-000180-howix091	24	15	,	,	,
cord-000180-howix091	24	16	when	when	WRB
cord-000180-howix091	24	17	co	co	NN
cord-000180-howix091	24	18	-	-	JJ
cord-000180-howix091	24	19	cultured	cultured	JJ
cord-000180-howix091	24	20	with	with	IN
cord-000180-howix091	24	21	a	a	DT
cord-000180-howix091	24	22	stably	stably	RB
cord-000180-howix091	24	23	transfected	transfecte	VBN
cord-000180-howix091	24	24	HSV-1	hsv-1	NN
cord-000180-howix091	24	25	gD	gD	NNP
cord-000180-howix091	24	26	-	-	HYPH
cord-000180-howix091	24	27	expressing	express	VBG
cord-000180-howix091	24	28	cell	cell	NN
cord-000180-howix091	24	29	line	line	NN
cord-000180-howix091	24	30	or	or	CC
cord-000180-howix091	24	31	after	after	IN
cord-000180-howix091	24	32	treatment	treatment	NN
cord-000180-howix091	24	33	with	with	IN
cord-000180-howix091	24	34	soluble	soluble	JJ
cord-000180-howix091	24	35	gD.	gD.	NNS
cord-000180-howix091	24	36	Inhibition	inhibition	NN
cord-000180-howix091	24	37	of	of	IN
cord-000180-howix091	24	38	NF	NF	NNP
cord-000180-howix091	24	39	-	-	HYPH
cord-000180-howix091	24	40	KB	KB	NNP
cord-000180-howix091	24	41	signalling	signalling	NN
cord-000180-howix091	24	42	by	by	IN
cord-000180-howix091	24	43	the	the	DT
cord-000180-howix091	24	44	introduction	introduction	NN
cord-000180-howix091	24	45	of	of	IN
cord-000180-howix091	24	46	a	a	DT
cord-000180-howix091	24	47	dominant	dominant	JJ
cord-000180-howix091	24	48	-	-	HYPH
cord-000180-howix091	24	49	negative	negative	JJ
cord-000180-howix091	24	50	NF	nf	NN
cord-000180-howix091	24	51	-	-	HYPH
cord-000180-howix091	24	52	kB	kb	CD
cord-000180-howix091	24	53	repressor	repressor	NN
cord-000180-howix091	24	54	abolished	abolish	VBD
cord-000180-howix091	24	55	protection	protection	NN
cord-000180-howix091	24	56	from	from	IN
cord-000180-howix091	24	57	gD	gD	NNP
cord-000180-howix091	24	58	-	-	HYPH
cord-000180-howix091	24	59	induced	induce	VBN
cord-000180-howix091	24	60	Fas	Fas	NNP
cord-000180-howix091	24	61	-	-	HYPH
cord-000180-howix091	24	62	mediated	mediate	VBN
cord-000180-howix091	24	63	apoptosis	apoptosis	NN
cord-000180-howix091	24	64	.	.	.
cord-000180-howix091	25	1	More	more	RBR
cord-000180-howix091	25	2	specifically	specifically	RB
cord-000180-howix091	25	3	,	,	,
cord-000180-howix091	25	4	the	the	DT
cord-000180-howix091	25	5	interaction	interaction	NN
cord-000180-howix091	25	6	of	of	IN
cord-000180-howix091	25	7	gD	gD	NNP
cord-000180-howix091	25	8	with	with	IN
cord-000180-howix091	25	9	one	one	CD
cord-000180-howix091	25	10	of	of	IN
cord-000180-howix091	25	11	the	the	DT
cord-000180-howix091	25	12	gD	gD	NNP
cord-000180-howix091	25	13	receptors	receptor	NNS
cord-000180-howix091	25	14	,	,	,
cord-000180-howix091	25	15	HVEM	HVEM	NNP
cord-000180-howix091	25	16	,	,	,
cord-000180-howix091	25	17	was	be	VBD
cord-000180-howix091	25	18	involved	involve	VBN
cord-000180-howix091	25	19	in	in	IN
cord-000180-howix091	25	20	preventing	prevent	VBG
cord-000180-howix091	25	21	apoptosis	apoptosis	NN
cord-000180-howix091	25	22	induction	induction	NN
cord-000180-howix091	25	23	[	[	-LRB-
cord-000180-howix091	25	24	1	1	CD
cord-000180-howix091	25	25	]	]	-RRB-
cord-000180-howix091	25	26	.	.	.
cord-000180-howix091	26	1	There	there	EX
cord-000180-howix091	26	2	are	be	VBP
cord-000180-howix091	26	3	reports	report	NNS
cord-000180-howix091	26	4	showing	show	VBG
cord-000180-howix091	26	5	that	that	IN
cord-000180-howix091	26	6	HSV-1	HSV-1	NNP
cord-000180-howix091	26	7	triggered	trigger	VBD
cord-000180-howix091	26	8	the	the	DT
cord-000180-howix091	26	9	translocation	translocation	NN
cord-000180-howix091	26	10	of	of	IN
cord-000180-howix091	26	11	NF	NF	NNP
cord-000180-howix091	26	12	-	-	HYPH
cord-000180-howix091	26	13	kB	kB	NNP
cord-000180-howix091	26	14	by	by	IN
cord-000180-howix091	26	15	six	six	CD
cord-000180-howix091	26	16	hours	hour	NNS
cord-000180-howix091	26	17	post	post	NN
cord-000180-howix091	26	18	-	-	NN
cord-000180-howix091	26	19	infection	infection	JJ
cord-000180-howix091	26	20	[	[	-LRB-
cord-000180-howix091	26	21	7	7	CD
cord-000180-howix091	26	22	]	]	-RRB-
cord-000180-howix091	26	23	.	.	.
cord-000180-howix091	27	1	However	however	RB
cord-000180-howix091	27	2	,	,	,
cord-000180-howix091	27	3	it	-PRON-	PRP
cord-000180-howix091	27	4	has	have	VBZ
cord-000180-howix091	27	5	come	come	VBN
cord-000180-howix091	27	6	to	to	TO
cord-000180-howix091	27	7	light	light	VB
cord-000180-howix091	27	8	that	that	IN
cord-000180-howix091	27	9	HSV-1	HSV-1	NNP
cord-000180-howix091	27	10	may	may	MD
cord-000180-howix091	27	11	induce	induce	VB
cord-000180-howix091	27	12	two	two	CD
cord-000180-howix091	27	13	distinct	distinct	JJ
cord-000180-howix091	27	14	phases	phase	NNS
cord-000180-howix091	27	15	of	of	IN
cord-000180-howix091	27	16	NF	NF	NNP
cord-000180-howix091	27	17	-	-	HYPH
cord-000180-howix091	27	18	kB	kb	CD
cord-000180-howix091	27	19	activity	activity	NN
cord-000180-howix091	27	20	.	.	.
cord-000180-howix091	28	1	The	the	DT
cord-000180-howix091	28	2	initial	initial	JJ
cord-000180-howix091	28	3	phase	phase	NN
cord-000180-howix091	28	4	is	be	VBZ
cord-000180-howix091	28	5	transient	transient	JJ
cord-000180-howix091	28	6	,	,	,
cord-000180-howix091	28	7	lasting	last	VBG
cord-000180-howix091	28	8	only	only	RB
cord-000180-howix091	28	9	two	two	CD
cord-000180-howix091	28	10	hours	hour	NNS
cord-000180-howix091	28	11	,	,	,
cord-000180-howix091	28	12	and	and	CC
cord-000180-howix091	28	13	occurred	occur	VBD
cord-000180-howix091	28	14	shortly	shortly	RB
cord-000180-howix091	28	15	after	after	IN
cord-000180-howix091	28	16	viral	viral	JJ
cord-000180-howix091	28	17	adsorption	adsorption	NN
cord-000180-howix091	28	18	by	by	IN
cord-000180-howix091	28	19	both	both	DT
cord-000180-howix091	28	20	wild	wild	JJ
cord-000180-howix091	28	21	-	-	HYPH
cord-000180-howix091	28	22	type	type	NN
cord-000180-howix091	28	23	and	and	CC
cord-000180-howix091	28	24	UV	uv	NN
cord-000180-howix091	28	25	-	-	HYPH
cord-000180-howix091	28	26	inactivated	inactivate	VBN
cord-000180-howix091	28	27	virus	virus	NN
cord-000180-howix091	28	28	particles	particle	NNS
cord-000180-howix091	28	29	.	.	.
cord-000180-howix091	29	1	This	this	DT
cord-000180-howix091	29	2	correlates	correlate	VBZ
cord-000180-howix091	29	3	with	with	IN
cord-000180-howix091	29	4	evidence	evidence	NN
cord-000180-howix091	29	5	showing	show	VBG
cord-000180-howix091	29	6	that	that	IN
cord-000180-howix091	29	7	supernatant	supernatant	NN
cord-000180-howix091	29	8	taken	take	VBN
cord-000180-howix091	29	9	from	from	IN
cord-000180-howix091	29	10	gD	gd	NN
cord-000180-howix091	29	11	-	-	HYPH
cord-000180-howix091	29	12	expressing	express	VBG
cord-000180-howix091	29	13	cells	cell	NNS
cord-000180-howix091	29	14	may	may	MD
cord-000180-howix091	29	15	also	also	RB
cord-000180-howix091	29	16	cause	cause	VB
cord-000180-howix091	29	17	an	an	DT
cord-000180-howix091	29	18	increase	increase	NN
cord-000180-howix091	29	19	in	in	IN
cord-000180-howix091	29	20	NF	NF	NNP
cord-000180-howix091	29	21	-	-	HYPH
cord-000180-howix091	29	22	KB	KB	NNP
cord-000180-howix091	29	23	binding	binding	NN
cord-000180-howix091	29	24	activity	activity	NN
cord-000180-howix091	29	25	in	in	IN
cord-000180-howix091	29	26	monocytoid	monocytoid	JJ
cord-000180-howix091	29	27	cells	cell	NNS
cord-000180-howix091	29	28	by	by	IN
cord-000180-howix091	29	29	30	30	CD
cord-000180-howix091	29	30	minutes	minute	NNS
cord-000180-howix091	29	31	post	post	NN
cord-000180-howix091	29	32	-	-	JJ
cord-000180-howix091	29	33	treatment	treatment	JJ
cord-000180-howix091	29	34	[	[	-LRB-
cord-000180-howix091	29	35	6	6	CD
cord-000180-howix091	29	36	]	]	-RRB-
cord-000180-howix091	29	37	.	.	.
cord-000180-howix091	30	1	A	a	DT
cord-000180-howix091	30	2	second	second	JJ
cord-000180-howix091	30	3	phase	phase	NN
cord-000180-howix091	30	4	relied	rely	VBN
cord-000180-howix091	30	5	on	on	IN
cord-000180-howix091	30	6	de	de	FW
cord-000180-howix091	30	7	novo	novo	NNP
cord-000180-howix091	30	8	viral	viral	JJ
cord-000180-howix091	30	9	protein	protein	NN
cord-000180-howix091	30	10	synthesis	synthesis	NN
cord-000180-howix091	30	11	as	as	IN
cord-000180-howix091	30	12	it	-PRON-	PRP
cord-000180-howix091	30	13	was	be	VBD
cord-000180-howix091	30	14	stimulated	stimulate	VBN
cord-000180-howix091	30	15	only	only	RB
cord-000180-howix091	30	16	by	by	IN
cord-000180-howix091	30	17	replication	replication	NN
cord-000180-howix091	30	18	-	-	HYPH
cord-000180-howix091	30	19	competent	competent	JJ
cord-000180-howix091	30	20	HSV-1	hsv-1	NN
cord-000180-howix091	30	21	and	and	CC
cord-000180-howix091	30	22	not	not	RB
cord-000180-howix091	30	23	by	by	IN
cord-000180-howix091	30	24	UV	uv	NN
cord-000180-howix091	30	25	-	-	HYPH
cord-000180-howix091	30	26	inactivated	inactivate	VBN
cord-000180-howix091	30	27	virions	virion	NNS
cord-000180-howix091	30	28	[	[	-LRB-
cord-000180-howix091	30	29	8	8	CD
cord-000180-howix091	30	30	]	]	-RRB-
cord-000180-howix091	30	31	.	.	.
cord-000180-howix091	31	1	During	during	IN
cord-000180-howix091	31	2	this	this	DT
cord-000180-howix091	31	3	second	second	JJ
cord-000180-howix091	31	4	phase	phase	NN
cord-000180-howix091	31	5	,	,	,
cord-000180-howix091	31	6	NF	NF	NNP
cord-000180-howix091	31	7	-	-	HYPH
cord-000180-howix091	31	8	kB	kB	NNP
cord-000180-howix091	31	9	complexes	complex	NNS
cord-000180-howix091	31	10	were	be	VBD
cord-000180-howix091	31	11	shown	show	VBN
cord-000180-howix091	31	12	to	to	TO
cord-000180-howix091	31	13	have	have	VB
cord-000180-howix091	31	14	associated	associate	VBN
cord-000180-howix091	31	15	with	with	IN
cord-000180-howix091	31	16	their	-PRON-	PRP$
cord-000180-howix091	31	17	consensus	consensus	NN
cord-000180-howix091	31	18	sequence	sequence	NN
cord-000180-howix091	31	19	found	find	VBN
cord-000180-howix091	31	20	in	in	IN
cord-000180-howix091	31	21	the	the	DT
cord-000180-howix091	31	22	promoter	promoter	NN
cord-000180-howix091	31	23	region	region	NN
cord-000180-howix091	31	24	that	that	WDT
cord-000180-howix091	31	25	drives	drive	VBZ
cord-000180-howix091	31	26	ICP0	ICP0	NNP
cord-000180-howix091	31	27	expression	expression	NN
cord-000180-howix091	31	28	[	[	-LRB-
cord-000180-howix091	31	29	8	8	CD
cord-000180-howix091	31	30	]	]	-RRB-
cord-000180-howix091	31	31	.	.	.
cord-000180-howix091	32	1	In	in	IN
cord-000180-howix091	32	2	comparison	comparison	NN
cord-000180-howix091	32	3	to	to	IN
cord-000180-howix091	32	4	wild	wild	JJ
cord-000180-howix091	32	5	-	-	HYPH
cord-000180-howix091	32	6	type	type	NN
cord-000180-howix091	32	7	gD	gD	NNP
cord-000180-howix091	32	8	,	,	,
cord-000180-howix091	32	9	a	a	DT
cord-000180-howix091	32	10	mutated	mutate	VBN
cord-000180-howix091	32	11	form	form	NN
cord-000180-howix091	32	12	of	of	IN
cord-000180-howix091	32	13	gD	gd	NN
cord-000180-howix091	32	14	that	that	WDT
cord-000180-howix091	32	15	was	be	VBD
cord-000180-howix091	32	16	unable	unable	JJ
cord-000180-howix091	32	17	to	to	TO
cord-000180-howix091	32	18	bind	bind	VB
cord-000180-howix091	32	19	to	to	IN
cord-000180-howix091	32	20	HVEM	HVEM	NNP
cord-000180-howix091	32	21	did	do	VBD
cord-000180-howix091	32	22	not	not	RB
cord-000180-howix091	32	23	stimulate	stimulate	VB
cord-000180-howix091	32	24	NF	NF	NNP
cord-000180-howix091	32	25	-	-	HYPH
cord-000180-howix091	32	26	KB	KB	NNP
cord-000180-howix091	32	27	activity	activity	NN
cord-000180-howix091	32	28	in	in	IN
cord-000180-howix091	32	29	cocultured	cocultured	JJ
cord-000180-howix091	32	30	monocytoid	monocytoid	NN
cord-000180-howix091	32	31	cells	cell	NNS
cord-000180-howix091	32	32	[	[	-LRB-
cord-000180-howix091	32	33	9	9	CD
cord-000180-howix091	32	34	]	]	-RRB-
cord-000180-howix091	32	35	.	.	.
cord-000180-howix091	33	1	HEp-2	HEp-2	NNP
cord-000180-howix091	33	2	cells	cell	NNS
cord-000180-howix091	33	3	,	,	,
cord-000180-howix091	33	4	which	which	WDT
cord-000180-howix091	33	5	do	do	VBP
cord-000180-howix091	33	6	not	not	RB
cord-000180-howix091	33	7	express	express	VB
cord-000180-howix091	33	8	HVEM	HVEM	NNP
cord-000180-howix091	33	9	,	,	,
cord-000180-howix091	33	10	lacked	lack	VBD
cord-000180-howix091	33	11	detectable	detectable	JJ
cord-000180-howix091	33	12	NF	NF	NNP
cord-000180-howix091	33	13	-	-	HYPH
cord-000180-howix091	33	14	kB	kB	NNP
cord-000180-howix091	33	15	signalling	signal	VBG
cord-000180-howix091	33	16	after	after	IN
cord-000180-howix091	33	17	infection	infection	NN
cord-000180-howix091	33	18	with	with	IN
cord-000180-howix091	33	19	UV	uv	NN
cord-000180-howix091	33	20	-	-	HYPH
cord-000180-howix091	33	21	inactivated	inactivate	VBN
cord-000180-howix091	33	22	HSV-1	hsv-1	NN
cord-000180-howix091	33	23	,	,	,
cord-000180-howix091	33	24	implying	imply	VBG
cord-000180-howix091	33	25	that	that	IN
cord-000180-howix091	33	26	gD	gd	NN
cord-000180-howix091	33	27	-	-	HYPH
cord-000180-howix091	33	28	mediated	mediate	VBN
cord-000180-howix091	33	29	NF	nf	NN
cord-000180-howix091	33	30	-	-	HYPH
cord-000180-howix091	33	31	kB	kb	CD
cord-000180-howix091	33	32	stimulation	stimulation	NN
cord-000180-howix091	33	33	may	may	MD
cord-000180-howix091	33	34	be	be	VB
cord-000180-howix091	33	35	dependent	dependent	JJ
cord-000180-howix091	33	36	on	on	IN
cord-000180-howix091	33	37	expression	expression	NN
cord-000180-howix091	33	38	of	of	IN
cord-000180-howix091	33	39	HVEM	HVEM	NNP
cord-000180-howix091	33	40	[	[	-LRB-
cord-000180-howix091	33	41	9	9	CD
cord-000180-howix091	33	42	]	]	-RRB-
cord-000180-howix091	33	43	.	.	.
cord-000180-howix091	34	1	Soluble	soluble	JJ
cord-000180-howix091	34	2	glycoproteins	glycoprotein	NNS
cord-000180-howix091	34	3	from	from	IN
cord-000180-howix091	34	4	beta	beta	NN
cord-000180-howix091	34	5	-	-	:
cord-000180-howix091	34	6	and	and	CC
cord-000180-howix091	34	7	gammaherpesviruses	gammaherpesviruse	NNS
cord-000180-howix091	34	8	can	can	MD
cord-000180-howix091	34	9	also	also	RB
cord-000180-howix091	34	10	stimulate	stimulate	VB
cord-000180-howix091	34	11	intracellular	intracellular	JJ
cord-000180-howix091	34	12	signalling	signal	VBG
cord-000180-howix091	34	13	pathways	pathway	NNS
cord-000180-howix091	34	14	;	;	:
cord-000180-howix091	34	15	gB	gB	NNP
cord-000180-howix091	34	16	of	of	IN
cord-000180-howix091	34	17	CMV	CMV	NNP
cord-000180-howix091	34	18	has	have	VBZ
cord-000180-howix091	34	19	been	be	VBN
cord-000180-howix091	34	20	shown	show	VBN
cord-000180-howix091	34	21	to	to	TO
cord-000180-howix091	34	22	stimulate	stimulate	VB
cord-000180-howix091	34	23	the	the	DT
cord-000180-howix091	34	24	differential	differential	JJ
cord-000180-howix091	34	25	expression	expression	NN
cord-000180-howix091	34	26	of	of	IN
cord-000180-howix091	34	27	cellular	cellular	JJ
cord-000180-howix091	34	28	transcription	transcription	NN
cord-000180-howix091	34	29	factors	factor	NNS
cord-000180-howix091	34	30	and	and	CC
cord-000180-howix091	34	31	interferon	interferon	NN
cord-000180-howix091	34	32	-	-	HYPH
cord-000180-howix091	34	33	stimulated	stimulate	VBN
cord-000180-howix091	34	34	genes	gene	NNS
cord-000180-howix091	34	35	(	(	-LRB-
cord-000180-howix091	34	36	ISGs	ISGs	NNP
cord-000180-howix091	34	37	)	)	-RRB-
cord-000180-howix091	34	38	,	,	,
cord-000180-howix091	34	39	and	and	CC
cord-000180-howix091	34	40	soluble	soluble	JJ
cord-000180-howix091	34	41	gp350	gp350	NN
cord-000180-howix091	34	42	of	of	IN
cord-000180-howix091	34	43	EBV	EBV	NNP
cord-000180-howix091	34	44	can	can	MD
cord-000180-howix091	34	45	trigger	trigger	VB
cord-000180-howix091	34	46	NF	NF	NNP
cord-000180-howix091	34	47	-	-	HYPH
cord-000180-howix091	34	48	kB	kb	CD
cord-000180-howix091	34	49	activation	activation	NN
cord-000180-howix091	34	50	[	[	-LRB-
cord-000180-howix091	34	51	10	10	CD
cord-000180-howix091	34	52	]	]	-RRB-
cord-000180-howix091	35	1	[	[	-LRB-
cord-000180-howix091	35	2	11	11	CD
cord-000180-howix091	35	3	]	]	-RRB-
cord-000180-howix091	35	4	[	[	-LRB-
cord-000180-howix091	35	5	12	12	CD
cord-000180-howix091	35	6	]	]	-RRB-
cord-000180-howix091	35	7	.	.	.
cord-000180-howix091	36	1	The	the	DT
cord-000180-howix091	36	2	treatment	treatment	NN
cord-000180-howix091	36	3	of	of	IN
cord-000180-howix091	36	4	cells	cell	NNS
cord-000180-howix091	36	5	with	with	IN
cord-000180-howix091	36	6	soluble	soluble	JJ
cord-000180-howix091	36	7	glycoproteins	glycoprotein	NNS
cord-000180-howix091	36	8	or	or	CC
cord-000180-howix091	36	9	UVinactivated	uvinactivated	JJ
cord-000180-howix091	36	10	virus	virus	NN
cord-000180-howix091	36	11	has	have	VBZ
cord-000180-howix091	36	12	provided	provide	VBN
cord-000180-howix091	36	13	strong	strong	JJ
cord-000180-howix091	36	14	evidence	evidence	NN
cord-000180-howix091	36	15	that	that	IN
cord-000180-howix091	36	16	HSV-1	HSV-1	NNP
cord-000180-howix091	36	17	binding	bind	VBG
cord-000180-howix091	36	18	to	to	IN
cord-000180-howix091	36	19	the	the	DT
cord-000180-howix091	36	20	plasma	plasma	NN
cord-000180-howix091	36	21	membrane	membrane	NN
cord-000180-howix091	36	22	triggers	trigger	VBZ
cord-000180-howix091	36	23	signal	signal	VBP
cord-000180-howix091	36	24	transduction	transduction	NN
cord-000180-howix091	36	25	in	in	IN
cord-000180-howix091	36	26	the	the	DT
cord-000180-howix091	36	27	host	host	NN
cord-000180-howix091	36	28	cell	cell	NN
cord-000180-howix091	36	29	as	as	IN
cord-000180-howix091	36	30	a	a	DT
cord-000180-howix091	36	31	prelude	prelude	NN
cord-000180-howix091	36	32	to	to	IN
cord-000180-howix091	36	33	infection	infection	NN
cord-000180-howix091	36	34	,	,	,
cord-000180-howix091	36	35	but	but	CC
cord-000180-howix091	36	36	interpretation	interpretation	NN
cord-000180-howix091	36	37	of	of	IN
cord-000180-howix091	36	38	these	these	DT
cord-000180-howix091	36	39	experiments	experiment	NNS
cord-000180-howix091	36	40	is	be	VBZ
cord-000180-howix091	36	41	not	not	RB
cord-000180-howix091	36	42	straightforward	straightforward	JJ
cord-000180-howix091	36	43	.	.	.
cord-000180-howix091	37	1	The	the	DT
cord-000180-howix091	37	2	use	use	NN
cord-000180-howix091	37	3	of	of	IN
cord-000180-howix091	37	4	soluble	soluble	JJ
cord-000180-howix091	37	5	glycoproteins	glycoprotein	NNS
cord-000180-howix091	37	6	does	do	VBZ
cord-000180-howix091	37	7	not	not	RB
cord-000180-howix091	37	8	mimic	mimic	VB
cord-000180-howix091	37	9	the	the	DT
cord-000180-howix091	37	10	binding	binding	NN
cord-000180-howix091	37	11	of	of	IN
cord-000180-howix091	37	12	individual	individual	JJ
cord-000180-howix091	37	13	virus	virus	NN
cord-000180-howix091	37	14	particles	particle	NNS
cord-000180-howix091	37	15	and	and	CC
cord-000180-howix091	37	16	the	the	DT
cord-000180-howix091	37	17	physiological	physiological	JJ
cord-000180-howix091	37	18	significance	significance	NN
cord-000180-howix091	37	19	of	of	IN
cord-000180-howix091	37	20	the	the	DT
cord-000180-howix091	37	21	results	result	NNS
cord-000180-howix091	37	22	is	be	VBZ
cord-000180-howix091	37	23	difficult	difficult	JJ
cord-000180-howix091	37	24	to	to	TO
cord-000180-howix091	37	25	assess	assess	VB
cord-000180-howix091	37	26	.	.	.
cord-000180-howix091	38	1	The	the	DT
cord-000180-howix091	38	2	use	use	NN
cord-000180-howix091	38	3	of	of	IN
cord-000180-howix091	38	4	UV	uv	NN
cord-000180-howix091	38	5	-	-	HYPH
cord-000180-howix091	38	6	inactivated	inactivate	VBN
cord-000180-howix091	38	7	particles	particle	NNS
cord-000180-howix091	38	8	in	in	IN
cord-000180-howix091	38	9	signalling	signal	VBG
cord-000180-howix091	38	10	studies	study	NNS
cord-000180-howix091	38	11	simulates	simulate	VBZ
cord-000180-howix091	38	12	infection	infection	NN
cord-000180-howix091	38	13	but	but	CC
cord-000180-howix091	38	14	these	these	DT
cord-000180-howix091	38	15	particles	particle	NNS
cord-000180-howix091	38	16	are	be	VBP
cord-000180-howix091	38	17	able	able	JJ
cord-000180-howix091	38	18	to	to	TO
cord-000180-howix091	38	19	enter	enter	VB
cord-000180-howix091	38	20	cells	cell	NNS
cord-000180-howix091	38	21	and	and	CC
cord-000180-howix091	38	22	deliver	deliver	VB
cord-000180-howix091	38	23	virion	virion	NN
cord-000180-howix091	38	24	proteins	protein	NNS
cord-000180-howix091	38	25	to	to	IN
cord-000180-howix091	38	26	the	the	DT
cord-000180-howix091	38	27	cytoplasm	cytoplasm	NN
cord-000180-howix091	38	28	.	.	.
cord-000180-howix091	39	1	Experiments	experiment	NNS
cord-000180-howix091	39	2	with	with	IN
cord-000180-howix091	39	3	UV	uv	NN
cord-000180-howix091	39	4	-	-	HYPH
cord-000180-howix091	39	5	inactivated	inactivate	VBN
cord-000180-howix091	39	6	particles	particle	NNS
cord-000180-howix091	39	7	do	do	VBP
cord-000180-howix091	39	8	not	not	RB
cord-000180-howix091	39	9	therefore	therefore	RB
cord-000180-howix091	39	10	distinguish	distinguish	VB
cord-000180-howix091	39	11	between	between	IN
cord-000180-howix091	39	12	events	event	NNS
cord-000180-howix091	39	13	arising	arise	VBG
cord-000180-howix091	39	14	from	from	IN
cord-000180-howix091	39	15	virus	virus	NN
cord-000180-howix091	39	16	binding	bind	VBG
cord-000180-howix091	39	17	from	from	IN
cord-000180-howix091	39	18	those	those	DT
cord-000180-howix091	39	19	resulting	result	VBG
cord-000180-howix091	39	20	from	from	IN
cord-000180-howix091	39	21	virus	virus	NN
cord-000180-howix091	39	22	entry	entry	NN
cord-000180-howix091	39	23	.	.	.
cord-000180-howix091	40	1	The	the	DT
cord-000180-howix091	40	2	main	main	JJ
cord-000180-howix091	40	3	focus	focus	NN
cord-000180-howix091	40	4	in	in	IN
cord-000180-howix091	40	5	these	these	DT
cord-000180-howix091	40	6	studies	study	NNS
cord-000180-howix091	40	7	was	be	VBD
cord-000180-howix091	40	8	to	to	TO
cord-000180-howix091	40	9	examine	examine	VB
cord-000180-howix091	40	10	signalling	signal	VBG
cord-000180-howix091	40	11	events	event	NNS
cord-000180-howix091	40	12	using	use	VBG
cord-000180-howix091	40	13	virus	virus	NN
cord-000180-howix091	40	14	particles	particle	NNS
cord-000180-howix091	40	15	that	that	WDT
cord-000180-howix091	40	16	are	be	VBP
cord-000180-howix091	40	17	capable	capable	JJ
cord-000180-howix091	40	18	of	of	IN
cord-000180-howix091	40	19	binding	bind	VBG
cord-000180-howix091	40	20	to	to	IN
cord-000180-howix091	40	21	the	the	DT
cord-000180-howix091	40	22	cell	cell	NN
cord-000180-howix091	40	23	surface	surface	NN
cord-000180-howix091	40	24	but	but	CC
cord-000180-howix091	40	25	are	be	VBP
cord-000180-howix091	40	26	incapable	incapable	JJ
cord-000180-howix091	40	27	of	of	IN
cord-000180-howix091	40	28	entry	entry	NN
cord-000180-howix091	40	29	due	due	IN
cord-000180-howix091	40	30	to	to	IN
cord-000180-howix091	40	31	the	the	DT
cord-000180-howix091	40	32	absence	absence	NN
cord-000180-howix091	40	33	of	of	IN
cord-000180-howix091	40	34	one	one	CD
cord-000180-howix091	40	35	of	of	IN
cord-000180-howix091	40	36	the	the	DT
cord-000180-howix091	40	37	three	three	CD
cord-000180-howix091	40	38	essential	essential	JJ
cord-000180-howix091	40	39	glycoproteins	glycoprotein	NNS
cord-000180-howix091	40	40	,	,	,
cord-000180-howix091	40	41	gB	gB	NNP
cord-000180-howix091	40	42	,	,	,
cord-000180-howix091	40	43	gD	gD	NNP
cord-000180-howix091	40	44	or	or	CC
cord-000180-howix091	40	45	gH	gh	XX
cord-000180-howix091	40	46	[	[	-LRB-
cord-000180-howix091	40	47	13	13	CD
cord-000180-howix091	40	48	]	]	-RRB-
cord-000180-howix091	40	49	[	[	-LRB-
cord-000180-howix091	40	50	14	14	CD
cord-000180-howix091	40	51	]	]	-RRB-
cord-000180-howix091	40	52	[	[	-LRB-
cord-000180-howix091	40	53	15	15	CD
cord-000180-howix091	40	54	]	]	-RRB-
cord-000180-howix091	40	55	[	[	-LRB-
cord-000180-howix091	40	56	16	16	CD
cord-000180-howix091	40	57	]	]	-RRB-
cord-000180-howix091	40	58	,	,	,
cord-000180-howix091	40	59	and	and	CC
cord-000180-howix091	40	60	to	to	TO
cord-000180-howix091	40	61	find	find	VB
cord-000180-howix091	40	62	whether	whether	IN
cord-000180-howix091	40	63	signalling	signalling	NN
cord-000180-howix091	40	64	occurs	occur	VBZ
cord-000180-howix091	40	65	at	at	IN
cord-000180-howix091	40	66	particle	particle	NN
cord-000180-howix091	40	67	concentrations	concentration	NNS
cord-000180-howix091	40	68	that	that	WDT
cord-000180-howix091	40	69	would	would	MD
cord-000180-howix091	40	70	mirror	mirror	VB
cord-000180-howix091	40	71	physiological	physiological	JJ
cord-000180-howix091	40	72	conditions	condition	NNS
cord-000180-howix091	40	73	.	.	.
cord-000180-howix091	41	1	All	all	DT
cord-000180-howix091	41	2	cells	cell	NNS
cord-000180-howix091	41	3	other	other	JJ
cord-000180-howix091	41	4	than	than	IN
cord-000180-howix091	41	5	Human	Human	NNP
cord-000180-howix091	41	6	Foreskin	Foreskin	NNP
cord-000180-howix091	41	7	Fibroblasts	Fibroblasts	NNPS
cord-000180-howix091	41	8	(	(	-LRB-
cord-000180-howix091	41	9	HFF	HFF	NNP
cord-000180-howix091	41	10	)	)	-RRB-
cord-000180-howix091	42	1	(	(	-LRB-
cord-000180-howix091	42	2	ATCC	ATCC	NNP
cord-000180-howix091	42	3	cell	cell	NN
cord-000180-howix091	42	4	line	line	NN
cord-000180-howix091	42	5	CRL-2522	CRL-2522	NNP
cord-000180-howix091	42	6	)	)	-RRB-
cord-000180-howix091	42	7	were	be	VBD
cord-000180-howix091	42	8	grown	grow	VBN
cord-000180-howix091	42	9	in	in	IN
cord-000180-howix091	42	10	Glasgow	Glasgow	NNP
cord-000180-howix091	42	11	Modified	Modified	NNP
cord-000180-howix091	42	12	Eagles	Eagles	NNP
cord-000180-howix091	42	13	Medium	Medium	NNP
cord-000180-howix091	42	14	supplemented	supplement	VBD
cord-000180-howix091	42	15	with	with	IN
cord-000180-howix091	42	16	10	10	CD
cord-000180-howix091	42	17	%	%	NN
cord-000180-howix091	42	18	foetal	foetal	JJ
cord-000180-howix091	42	19	bovine	bovine	JJ
cord-000180-howix091	42	20	serum	serum	NN
cord-000180-howix091	42	21	,	,	,
cord-000180-howix091	42	22	4	4	CD
cord-000180-howix091	42	23	mM	mm	CD
cord-000180-howix091	42	24	glutamine	glutamine	NN
cord-000180-howix091	42	25	,	,	,
cord-000180-howix091	42	26	100	100	CD
cord-000180-howix091	42	27	units/	units/	CD
cord-000180-howix091	43	1	ml	ml	NNP
cord-000180-howix091	43	2	penicillin	penicillin	NN
cord-000180-howix091	43	3	and	and	CC
cord-000180-howix091	43	4	100	100	CD
cord-000180-howix091	43	5	ug	ug	NNP
cord-000180-howix091	43	6	/	/	SYM
cord-000180-howix091	43	7	ml	ml	NNS
cord-000180-howix091	43	8	streptomycin	streptomycin	NNS
cord-000180-howix091	43	9	.	.	.
cord-000180-howix091	44	1	HFF	HFF	NNP
cord-000180-howix091	44	2	cells	cell	NNS
cord-000180-howix091	44	3	were	be	VBD
cord-000180-howix091	44	4	grown	grow	VBN
cord-000180-howix091	44	5	in	in	IN
cord-000180-howix091	44	6	Dulbecco	Dulbecco	NNP
cord-000180-howix091	44	7	modified	modify	VBN
cord-000180-howix091	44	8	Eagles	Eagles	NNP
cord-000180-howix091	44	9	medium	medium	NN
cord-000180-howix091	44	10	supplemented	supplement	VBN
cord-000180-howix091	44	11	as	as	IN
cord-000180-howix091	44	12	described	describe	VBN
cord-000180-howix091	44	13	above	above	IN
cord-000180-howix091	44	14	but	but	CC
cord-000180-howix091	44	15	with	with	IN
cord-000180-howix091	44	16	the	the	DT
cord-000180-howix091	44	17	addition	addition	NN
cord-000180-howix091	44	18	of	of	IN
cord-000180-howix091	44	19	1x	1x	CD
cord-000180-howix091	44	20	MEM	mem	NN
cord-000180-howix091	44	21	non	non	JJ
cord-000180-howix091	44	22	-	-	JJ
cord-000180-howix091	44	23	essential	essential	JJ
cord-000180-howix091	44	24	amino	amino	JJ
cord-000180-howix091	44	25	acids	acid	NNS
cord-000180-howix091	44	26	.	.	.
cord-000180-howix091	45	1	Working	work	VBG
cord-000180-howix091	45	2	stocks	stock	NNS
cord-000180-howix091	45	3	of	of	IN
cord-000180-howix091	45	4	HSV-1	HSV-1	NNP
cord-000180-howix091	45	5	SC16	SC16	NNP
cord-000180-howix091	45	6	were	be	VBD
cord-000180-howix091	45	7	grown	grow	VBN
cord-000180-howix091	45	8	on	on	IN
cord-000180-howix091	45	9	HaCaT	HaCaT	NNP
cord-000180-howix091	45	10	cells	cell	NNS
cord-000180-howix091	45	11	and	and	CC
cord-000180-howix091	45	12	assayed	assay	VBN
cord-000180-howix091	45	13	on	on	IN
cord-000180-howix091	45	14	Vero	Vero	NNP
cord-000180-howix091	45	15	cells	cell	NNS
cord-000180-howix091	45	16	[	[	-LRB-
cord-000180-howix091	45	17	17	17	CD
cord-000180-howix091	45	18	]	]	-RRB-
cord-000180-howix091	45	19	.	.	.
cord-000180-howix091	46	1	Mutant	mutant	JJ
cord-000180-howix091	46	2	viruses	virus	NNS
cord-000180-howix091	46	3	lacking	lack	VBG
cord-000180-howix091	46	4	functional	functional	JJ
cord-000180-howix091	46	5	genes	gene	NNS
cord-000180-howix091	46	6	for	for	IN
cord-000180-howix091	46	7	gH	gh	NN
cord-000180-howix091	46	8	(	(	-LRB-
cord-000180-howix091	46	9	SCgHZ	SCgHZ	NNS
cord-000180-howix091	46	10	)	)	-RRB-
cord-000180-howix091	46	11	[	[	-LRB-
cord-000180-howix091	46	12	14	14	CD
cord-000180-howix091	46	13	]	]	-RRB-
cord-000180-howix091	46	14	,	,	.
cord-000180-howix091	47	1	gB	gB	NNP
cord-000180-howix091	48	1	(	(	-LRB-
cord-000180-howix091	48	2	HFEMdUL27-lacZ	HFEMdUL27-lacZ	NNP
cord-000180-howix091	48	3	)	)	-RRB-
cord-000180-howix091	48	4	[	[	-LRB-
cord-000180-howix091	48	5	18	18	CD
cord-000180-howix091	48	6	]	]	-RRB-
cord-000180-howix091	48	7	or	or	CC
cord-000180-howix091	48	8	gD	gD	.
cord-000180-howix091	49	1	(	(	-LRB-
cord-000180-howix091	49	2	SC16gDdelZ	SC16gDdelZ	NNP
cord-000180-howix091	49	3	)	)	-RRB-
cord-000180-howix091	50	1	[	[	-LRB-
cord-000180-howix091	50	2	18	18	CD
cord-000180-howix091	50	3	]	]	-RRB-
cord-000180-howix091	50	4	were	be	VBD
cord-000180-howix091	50	5	grown	grow	VBN
cord-000180-howix091	50	6	and	and	CC
cord-000180-howix091	50	7	assayed	assay	VBN
cord-000180-howix091	50	8	on	on	IN
cord-000180-howix091	50	9	helper	helper	NN
cord-000180-howix091	50	10	cell	cell	NN
cord-000180-howix091	50	11	lines	line	NNS
cord-000180-howix091	50	12	expressing	express	VBG
cord-000180-howix091	50	13	the	the	DT
cord-000180-howix091	50	14	corresponding	correspond	VBG
cord-000180-howix091	50	15	glycoprotein	glycoprotein	NN
cord-000180-howix091	50	16	:	:	:
cord-000180-howix091	50	17	CR1	CR1	NNP
cord-000180-howix091	50	18	cells	cell	NNS
cord-000180-howix091	50	19	,	,	,
cord-000180-howix091	50	20	expressing	express	VBG
cord-000180-howix091	50	21	gH	gH	NNP
cord-000180-howix091	50	22	[	[	-LRB-
cord-000180-howix091	50	23	19	19	CD
cord-000180-howix091	50	24	]	]	-RRB-
cord-000180-howix091	50	25	;	;	:
cord-000180-howix091	50	26	D6	d6	NN
cord-000180-howix091	50	27	cells	cell	NNS
cord-000180-howix091	50	28	expressing	express	VBG
cord-000180-howix091	50	29	gB	gB	NNP
cord-000180-howix091	50	30	[	[	-LRB-
cord-000180-howix091	50	31	13	13	CD
cord-000180-howix091	50	32	]	]	-RRB-
cord-000180-howix091	50	33	;	;	:
cord-000180-howix091	50	34	and	and	CC
cord-000180-howix091	50	35	VD60	VD60	NNP
cord-000180-howix091	50	36	cells	cell	NNS
cord-000180-howix091	50	37	expressing	express	VBG
cord-000180-howix091	50	38	gD	gD	NNP
cord-000180-howix091	50	39	[	[	-LRB-
cord-000180-howix091	50	40	18	18	CD
cord-000180-howix091	50	41	]	]	-RRB-
cord-000180-howix091	50	42	.	.	.
cord-000180-howix091	51	1	All	all	DT
cord-000180-howix091	51	2	stocks	stock	NNS
cord-000180-howix091	51	3	were	be	VBD
cord-000180-howix091	51	4	grown	grow	VBN
cord-000180-howix091	51	5	using	use	VBG
cord-000180-howix091	51	6	an	an	DT
cord-000180-howix091	51	7	MOI	MOI	NNP
cord-000180-howix091	51	8	of	of	IN
cord-000180-howix091	51	9	0.1	0.1	CD
cord-000180-howix091	51	10	.	.	.
cord-000180-howix091	52	1	Purified	purified	JJ
cord-000180-howix091	52	2	preparations	preparation	NNS
cord-000180-howix091	52	3	of	of	IN
cord-000180-howix091	52	4	WT	WT	NNP
cord-000180-howix091	52	5	virus	virus	NN
cord-000180-howix091	52	6	,	,	,
cord-000180-howix091	52	7	or	or	CC
cord-000180-howix091	52	8	of	of	IN
cord-000180-howix091	52	9	virions	virion	NNS
cord-000180-howix091	52	10	lacking	lack	VBG
cord-000180-howix091	52	11	individual	individual	JJ
cord-000180-howix091	52	12	glycoproteins	glycoprotein	NNS
cord-000180-howix091	52	13	,	,	,
cord-000180-howix091	52	14	were	be	VBD
cord-000180-howix091	52	15	produced	produce	VBN
cord-000180-howix091	52	16	as	as	IN
cord-000180-howix091	52	17	previously	previously	RB
cord-000180-howix091	52	18	described	describe	VBN
cord-000180-howix091	52	19	[	[	-LRB-
cord-000180-howix091	52	20	20	20	CD
cord-000180-howix091	52	21	]	]	-RRB-
cord-000180-howix091	52	22	.	.	.
cord-000180-howix091	53	1	Purified	purified	JJ
cord-000180-howix091	53	2	preparations	preparation	NNS
cord-000180-howix091	53	3	were	be	VBD
cord-000180-howix091	53	4	assayed	assay	VBN
cord-000180-howix091	53	5	for	for	IN
cord-000180-howix091	53	6	particle	particle	NN
cord-000180-howix091	53	7	numbers	number	NNS
cord-000180-howix091	53	8	using	use	VBG
cord-000180-howix091	53	9	electron	electron	NN
cord-000180-howix091	53	10	microscopy	microscopy	NNS
cord-000180-howix091	53	11	[	[	-LRB-
cord-000180-howix091	53	12	21	21	CD
cord-000180-howix091	53	13	]	]	-RRB-
cord-000180-howix091	53	14	and	and	CC
cord-000180-howix091	53	15	for	for	IN
cord-000180-howix091	53	16	infectivity	infectivity	NN
cord-000180-howix091	53	17	by	by	IN
cord-000180-howix091	53	18	plaque	plaque	NN
cord-000180-howix091	53	19	assay	assay	NN
cord-000180-howix091	53	20	on	on	IN
cord-000180-howix091	53	21	Vero	Vero	NNP
cord-000180-howix091	53	22	cells	cell	NNS
cord-000180-howix091	53	23	or	or	CC
cord-000180-howix091	53	24	,	,	,
cord-000180-howix091	53	25	in	in	IN
cord-000180-howix091	53	26	the	the	DT
cord-000180-howix091	53	27	case	case	NN
cord-000180-howix091	53	28	of	of	IN
cord-000180-howix091	53	29	glycoprotein	glycoprotein	NN
cord-000180-howix091	53	30	-	-	HYPH
cord-000180-howix091	53	31	deficient	deficient	JJ
cord-000180-howix091	53	32	virions	virion	NNS
cord-000180-howix091	53	33	,	,	,
cord-000180-howix091	53	34	on	on	IN
cord-000180-howix091	53	35	the	the	DT
cord-000180-howix091	53	36	relevant	relevant	JJ
cord-000180-howix091	53	37	helper	helper	NN
cord-000180-howix091	53	38	cell	cell	NN
cord-000180-howix091	53	39	line	line	NN
cord-000180-howix091	53	40	.	.	.
cord-000180-howix091	54	1	Preparations	preparation	NNS
cord-000180-howix091	54	2	of	of	IN
cord-000180-howix091	54	3	WT	WT	NNP
cord-000180-howix091	54	4	virions	virion	NNS
cord-000180-howix091	54	5	had	have	VBD
cord-000180-howix091	54	6	a	a	DT
cord-000180-howix091	54	7	particle	particle	NN
cord-000180-howix091	54	8	to	to	IN
cord-000180-howix091	54	9	infectivity	infectivity	NN
cord-000180-howix091	54	10	ratio	ratio	NN
cord-000180-howix091	54	11	of	of	IN
cord-000180-howix091	54	12	3610	3610	CD
cord-000180-howix091	54	13	1	1	CD
cord-000180-howix091	54	14	.	.	.
cord-000180-howix091	55	1	Preparations	preparation	NNS
cord-000180-howix091	55	2	of	of	IN
cord-000180-howix091	55	3	gHnegative	gHnegative	NNP
cord-000180-howix091	55	4	,	,	,
cord-000180-howix091	55	5	gD	gD	NNP
cord-000180-howix091	55	6	-	-	HYPH
cord-000180-howix091	55	7	negative	negative	JJ
cord-000180-howix091	55	8	and	and	CC
cord-000180-howix091	55	9	gB	gB	NNP
cord-000180-howix091	55	10	negative	negative	JJ
cord-000180-howix091	55	11	virions	virion	NNS
cord-000180-howix091	55	12	had	have	VBD
cord-000180-howix091	55	13	particle	particle	NN
cord-000180-howix091	55	14	to	to	IN
cord-000180-howix091	55	15	infectivity	infectivity	NN
cord-000180-howix091	55	16	ratios	ratio	NNS
cord-000180-howix091	55	17	of	of	IN
cord-000180-howix091	55	18	2610	2610	CD
cord-000180-howix091	55	19	10	10	CD
cord-000180-howix091	55	20	,	,	,
cord-000180-howix091	55	21	5610	5610	CD
cord-000180-howix091	55	22	6	6	CD
cord-000180-howix091	55	23	and	and	CC
cord-000180-howix091	55	24	3610	3610	CD
cord-000180-howix091	55	25	6	6	CD
cord-000180-howix091	55	26	respectively	respectively	RB
cord-000180-howix091	55	27	.	.	.
cord-000180-howix091	56	1	The	the	DT
cord-000180-howix091	56	2	maximum	maximum	JJ
cord-000180-howix091	56	3	virion	virion	NN
cord-000180-howix091	56	4	dose	dose	NN
cord-000180-howix091	56	5	of	of	IN
cord-000180-howix091	56	6	entry	entry	NN
cord-000180-howix091	56	7	-	-	HYPH
cord-000180-howix091	56	8	incompetent	incompetent	JJ
cord-000180-howix091	56	9	virions	virion	NNS
cord-000180-howix091	56	10	used	use	VBN
cord-000180-howix091	56	11	in	in	IN
cord-000180-howix091	56	12	the	the	DT
cord-000180-howix091	56	13	experiments	experiment	NNS
cord-000180-howix091	56	14	described	describe	VBN
cord-000180-howix091	56	15	in	in	IN
cord-000180-howix091	56	16	this	this	DT
cord-000180-howix091	56	17	paper	paper	NN
cord-000180-howix091	56	18	was	be	VBD
cord-000180-howix091	56	19	1000	1000	CD
cord-000180-howix091	56	20	particles	particle	NNS
cord-000180-howix091	56	21	per	per	IN
cord-000180-howix091	56	22	cell	cell	NN
cord-000180-howix091	56	23	and	and	CC
cord-000180-howix091	56	24	it	-PRON-	PRP
cord-000180-howix091	56	25	therefore	therefore	RB
cord-000180-howix091	56	26	follows	follow	VBZ
cord-000180-howix091	56	27	that	that	IN
cord-000180-howix091	56	28	in	in	IN
cord-000180-howix091	56	29	the	the	DT
cord-000180-howix091	56	30	maximum	maximum	JJ
cord-000180-howix091	56	31	infectivity	infectivity	NN
cord-000180-howix091	56	32	of	of	IN
cord-000180-howix091	56	33	a	a	DT
cord-000180-howix091	56	34	preparation	preparation	NN
cord-000180-howix091	56	35	of	of	IN
cord-000180-howix091	56	36	an	an	DT
cord-000180-howix091	56	37	entry	entry	NN
cord-000180-howix091	56	38	-	-	HYPH
cord-000180-howix091	56	39	defective	defective	JJ
cord-000180-howix091	56	40	virus	virus	NN
cord-000180-howix091	56	41	(	(	-LRB-
cord-000180-howix091	56	42	i.e.	i.e.	FW
cord-000180-howix091	56	43	using	use	VBG
cord-000180-howix091	56	44	gB	gb	JJ
cord-000180-howix091	56	45	-	-	JJ
cord-000180-howix091	56	46	negative	negative	JJ
cord-000180-howix091	56	47	virions	virion	NNS
cord-000180-howix091	56	48	)	)	-RRB-
cord-000180-howix091	56	49	would	would	MD
cord-000180-howix091	56	50	be	be	VB
cord-000180-howix091	56	51	less	less	JJR
cord-000180-howix091	56	52	than	than	IN
cord-000180-howix091	56	53	one	one	CD
cord-000180-howix091	56	54	cell	cell	NN
cord-000180-howix091	56	55	per	per	IN
cord-000180-howix091	56	56	thousand	thousand	CD
cord-000180-howix091	56	57	.	.	.
cord-000180-howix091	57	1	Virus	virus	NN
cord-000180-howix091	57	2	preparations	preparation	NNS
cord-000180-howix091	57	3	were	be	VBD
cord-000180-howix091	57	4	deglycosylated	deglycosylate	VBN
cord-000180-howix091	57	5	with	with	IN
cord-000180-howix091	57	6	500	500	CD
cord-000180-howix091	57	7	U	u	NN
cord-000180-howix091	57	8	of	of	IN
cord-000180-howix091	57	9	PNGase	PNGase	NNP
cord-000180-howix091	57	10	F	F	NNP
cord-000180-howix091	57	11	for	for	IN
cord-000180-howix091	57	12	18	18	CD
cord-000180-howix091	57	13	hrs	hrs	NN
cord-000180-howix091	57	14	at	at	IN
cord-000180-howix091	57	15	37uC	37uc	CD
cord-000180-howix091	57	16	in	in	IN
cord-000180-howix091	57	17	the	the	DT
cord-000180-howix091	57	18	absence	absence	NN
cord-000180-howix091	57	19	of	of	IN
cord-000180-howix091	57	20	denaturing	denature	VBG
cord-000180-howix091	57	21	buffer	buffer	NN
cord-000180-howix091	57	22	[	[	-LRB-
cord-000180-howix091	57	23	22	22	CD
cord-000180-howix091	57	24	]	]	-RRB-
cord-000180-howix091	57	25	.	.	.
cord-000180-howix091	58	1	Removal	removal	NN
cord-000180-howix091	58	2	of	of	IN
cord-000180-howix091	58	3	N	n	NN
cord-000180-howix091	58	4	-	-	HYPH
cord-000180-howix091	58	5	linked	link	VBN
cord-000180-howix091	58	6	sugars	sugar	NNS
cord-000180-howix091	58	7	was	be	VBD
cord-000180-howix091	58	8	confirmed	confirm	VBN
cord-000180-howix091	58	9	by	by	IN
cord-000180-howix091	58	10	a	a	DT
cord-000180-howix091	58	11	shift	shift	NN
cord-000180-howix091	58	12	in	in	IN
cord-000180-howix091	58	13	the	the	DT
cord-000180-howix091	58	14	electrophoretic	electrophoretic	JJ
cord-000180-howix091	58	15	mobility	mobility	NN
cord-000180-howix091	58	16	of	of	IN
cord-000180-howix091	58	17	gD	gD	NNP
cord-000180-howix091	58	18	on	on	IN
cord-000180-howix091	58	19	a	a	DT
cord-000180-howix091	58	20	protein	protein	NN
cord-000180-howix091	58	21	denaturing	denature	VBG
cord-000180-howix091	58	22	gel	gel	NN
cord-000180-howix091	58	23	.	.	.
cord-000180-howix091	59	1	Human	human	JJ
cord-000180-howix091	59	2	foreskin	foreskin	NN
cord-000180-howix091	59	3	fibroblast	fibroblast	NN
cord-000180-howix091	59	4	cells	cell	NNS
cord-000180-howix091	59	5	(	(	-LRB-
cord-000180-howix091	59	6	HFF	HFF	NNP
cord-000180-howix091	59	7	)	)	-RRB-
cord-000180-howix091	59	8	were	be	VBD
cord-000180-howix091	59	9	seeded	seed	VBN
cord-000180-howix091	59	10	at	at	IN
cord-000180-howix091	59	11	1.5610	1.5610	CD
cord-000180-howix091	59	12	6	6	CD
cord-000180-howix091	59	13	in	in	IN
cord-000180-howix091	59	14	a	a	DT
cord-000180-howix091	59	15	175	175	CD
cord-000180-howix091	59	16	2	2	CD
cord-000180-howix091	59	17	cm	cm	NN
cord-000180-howix091	59	18	flask	flask	NN
cord-000180-howix091	59	19	and	and	CC
cord-000180-howix091	59	20	grown	grow	VBN
cord-000180-howix091	59	21	to	to	IN
cord-000180-howix091	59	22	90	90	CD
cord-000180-howix091	59	23	%	%	NN
cord-000180-howix091	59	24	confluence	confluence	NN
cord-000180-howix091	60	1	then	then	RB
cord-000180-howix091	60	2	growtharrested	growtharreste	VBN
cord-000180-howix091	60	3	in	in	IN
cord-000180-howix091	60	4	medium	medium	NN
cord-000180-howix091	60	5	supplemented	supplement	VBN
cord-000180-howix091	60	6	with	with	IN
cord-000180-howix091	60	7	only	only	RB
cord-000180-howix091	60	8	100	100	CD
cord-000180-howix091	60	9	U	u	NN
cord-000180-howix091	60	10	/	/	SYM
cord-000180-howix091	60	11	ml	ml	NNP
cord-000180-howix091	60	12	Penicillin	Penicillin	NNP
cord-000180-howix091	60	13	-	-	HYPH
cord-000180-howix091	60	14	G	G	NNP
cord-000180-howix091	60	15	and	and	CC
cord-000180-howix091	60	16	100	100	CD
cord-000180-howix091	60	17	mg	mg	NNP
cord-000180-howix091	60	18	/	/	SYM
cord-000180-howix091	60	19	ml	ml	NNP
cord-000180-howix091	60	20	Streptomycin	Streptomycin	NNP
cord-000180-howix091	60	21	for	for	IN
cord-000180-howix091	60	22	five	five	CD
cord-000180-howix091	60	23	days	day	NNS
cord-000180-howix091	60	24	.	.	.
cord-000180-howix091	61	1	Real	real	JJ
cord-000180-howix091	61	2	-	-	HYPH
cord-000180-howix091	61	3	time	time	NN
cord-000180-howix091	61	4	PCR	PCR	NNP
cord-000180-howix091	61	5	experiments	experiment	NNS
cord-000180-howix091	61	6	were	be	VBD
cord-000180-howix091	61	7	conducted	conduct	VBN
cord-000180-howix091	61	8	with	with	IN
cord-000180-howix091	61	9	growth	growth	NN
cord-000180-howix091	61	10	-	-	HYPH
cord-000180-howix091	61	11	arrested	arrest	VBN
cord-000180-howix091	61	12	HFFs	hff	NNS
cord-000180-howix091	61	13	that	that	WDT
cord-000180-howix091	61	14	were	be	VBD
cord-000180-howix091	61	15	inoculated	inoculate	VBN
cord-000180-howix091	61	16	in	in	IN
cord-000180-howix091	61	17	triplicate	triplicate	NN
cord-000180-howix091	61	18	with	with	IN
cord-000180-howix091	61	19	1000	1000	CD
cord-000180-howix091	61	20	particles	particle	NNS
cord-000180-howix091	61	21	/	/	SYM
cord-000180-howix091	61	22	cell	cell	NN
cord-000180-howix091	61	23	of	of	IN
cord-000180-howix091	61	24	entry	entry	NN
cord-000180-howix091	61	25	-	-	HYPH
cord-000180-howix091	61	26	defective	defective	JJ
cord-000180-howix091	61	27	HSV-1	hsv-1	NN
cord-000180-howix091	61	28	in	in	IN
cord-000180-howix091	61	29	warm	warm	JJ
cord-000180-howix091	61	30	,	,	,
cord-000180-howix091	61	31	serum	serum	NN
cord-000180-howix091	61	32	-	-	HYPH
cord-000180-howix091	61	33	free	free	JJ
cord-000180-howix091	61	34	medium	medium	NN
cord-000180-howix091	61	35	,	,	,
cord-000180-howix091	61	36	with	with	IN
cord-000180-howix091	61	37	parallel	parallel	JJ
cord-000180-howix091	61	38	mock	mock	NN
cord-000180-howix091	61	39	-	-	HYPH
cord-000180-howix091	61	40	infected	infect	VBN
cord-000180-howix091	61	41	cells	cell	NNS
cord-000180-howix091	61	42	that	that	WDT
cord-000180-howix091	61	43	received	receive	VBD
cord-000180-howix091	61	44	an	an	DT
cord-000180-howix091	61	45	equivalent	equivalent	JJ
cord-000180-howix091	61	46	volume	volume	NN
cord-000180-howix091	61	47	of	of	IN
cord-000180-howix091	61	48	PBS	PBS	NNP
cord-000180-howix091	61	49	in	in	IN
cord-000180-howix091	61	50	warm	warm	JJ
cord-000180-howix091	61	51	serumfree	serumfree	NN
cord-000180-howix091	61	52	medium	medium	NN
cord-000180-howix091	61	53	.	.	.
cord-000180-howix091	62	1	Inoculations	inoculation	NNS
cord-000180-howix091	62	2	took	take	VBD
cord-000180-howix091	62	3	place	place	NN
cord-000180-howix091	62	4	at	at	IN
cord-000180-howix091	62	5	37uC.	37uc.	CD
cord-000180-howix091	63	1	At	at	IN
cord-000180-howix091	63	2	the	the	DT
cord-000180-howix091	63	3	indicated	indicate	VBN
cord-000180-howix091	63	4	times	time	NNS
cord-000180-howix091	63	5	after	after	IN
cord-000180-howix091	63	6	the	the	DT
cord-000180-howix091	63	7	addition	addition	NN
cord-000180-howix091	63	8	of	of	IN
cord-000180-howix091	63	9	virus	virus	NN
cord-000180-howix091	63	10	,	,	,
cord-000180-howix091	63	11	the	the	DT
cord-000180-howix091	63	12	medium	medium	NN
cord-000180-howix091	63	13	was	be	VBD
cord-000180-howix091	63	14	removed	remove	VBN
cord-000180-howix091	63	15	,	,	,
cord-000180-howix091	63	16	the	the	DT
cord-000180-howix091	63	17	cells	cell	NNS
cord-000180-howix091	63	18	were	be	VBD
cord-000180-howix091	63	19	lysed	lyse	VBN
cord-000180-howix091	63	20	with	with	IN
cord-000180-howix091	63	21	TRI	TRI	NNP
cord-000180-howix091	63	22	Reagent	Reagent	NNP
cord-000180-howix091	63	23	(	(	-LRB-
cord-000180-howix091	63	24	Sigma	Sigma	NNP
cord-000180-howix091	63	25	)	)	-RRB-
cord-000180-howix091	63	26	and	and	CC
cord-000180-howix091	63	27	total	total	JJ
cord-000180-howix091	63	28	RNA	RNA	NNP
cord-000180-howix091	63	29	was	be	VBD
cord-000180-howix091	63	30	immediately	immediately	RB
cord-000180-howix091	63	31	purified	purify	VBN
cord-000180-howix091	63	32	.	.	.
cord-000180-howix091	64	1	For	for	IN
cord-000180-howix091	64	2	each	each	DT
cord-000180-howix091	64	3	entry	entry	NN
cord-000180-howix091	64	4	-	-	HYPH
cord-000180-howix091	64	5	defective	defective	JJ
cord-000180-howix091	64	6	HSV-1	HSV-1	NNP
cord-000180-howix091	64	7	mutant	mutant	JJ
cord-000180-howix091	64	8	,	,	,
cord-000180-howix091	64	9	three	three	CD
cord-000180-howix091	64	10	independent	independent	JJ
cord-000180-howix091	64	11	biological	biological	JJ
cord-000180-howix091	64	12	replicates	replicate	NNS
cord-000180-howix091	64	13	were	be	VBD
cord-000180-howix091	64	14	carried	carry	VBN
cord-000180-howix091	64	15	out	out	RP
cord-000180-howix091	64	16	.	.	.
cord-000180-howix091	65	1	Microarray	microarray	JJ
cord-000180-howix091	65	2	experiments	experiment	NNS
cord-000180-howix091	65	3	were	be	VBD
cord-000180-howix091	65	4	conducted	conduct	VBN
cord-000180-howix091	65	5	under	under	IN
cord-000180-howix091	65	6	the	the	DT
cord-000180-howix091	65	7	same	same	JJ
cord-000180-howix091	65	8	conditions	condition	NNS
cord-000180-howix091	65	9	using	use	VBG
cord-000180-howix091	65	10	wild	wild	JJ
cord-000180-howix091	65	11	-	-	HYPH
cord-000180-howix091	65	12	type	type	NN
cord-000180-howix091	65	13	HSV-1	HSV-1	NNP
cord-000180-howix091	65	14	(	(	-LRB-
cord-000180-howix091	65	15	SC16	SC16	NNP
cord-000180-howix091	65	16	)	)	-RRB-
cord-000180-howix091	65	17	at	at	IN
cord-000180-howix091	65	18	an	an	DT
cord-000180-howix091	65	19	MOI	MOI	NNP
cord-000180-howix091	65	20	of	of	IN
cord-000180-howix091	65	21	20	20	CD
cord-000180-howix091	65	22	.	.	.
cord-000180-howix091	66	1	Total	Total	NNP
cord-000180-howix091	66	2	RNA	RNA	NNP
cord-000180-howix091	66	3	was	be	VBD
cord-000180-howix091	66	4	isolated	isolate	VBN
cord-000180-howix091	66	5	from	from	IN
cord-000180-howix091	66	6	TRI	TRI	NNP
cord-000180-howix091	66	7	reagent	reagent	NN
cord-000180-howix091	66	8	lysates	lysate	NNS
cord-000180-howix091	66	9	as	as	IN
cord-000180-howix091	66	10	per	per	IN
cord-000180-howix091	66	11	the	the	DT
cord-000180-howix091	66	12	manufacturer	manufacturer	NN
cord-000180-howix091	66	13	's	's	POS
cord-000180-howix091	66	14	instructions	instruction	NNS
cord-000180-howix091	66	15	.	.	.
cord-000180-howix091	67	1	Contaminating	contaminate	VBG
cord-000180-howix091	67	2	genomic	genomic	JJ
cord-000180-howix091	67	3	DNA	dna	NN
cord-000180-howix091	67	4	was	be	VBD
cord-000180-howix091	67	5	digested	digest	VBN
cord-000180-howix091	67	6	with	with	IN
cord-000180-howix091	67	7	2	2	CD
cord-000180-howix091	67	8	U	u	NN
cord-000180-howix091	67	9	DNase	DNase	NNP
cord-000180-howix091	67	10	I	i	NN
cord-000180-howix091	67	11	(	(	-LRB-
cord-000180-howix091	67	12	Invitrogen	Invitrogen	NNP
cord-000180-howix091	67	13	)	)	-RRB-
cord-000180-howix091	67	14	and	and	CC
cord-000180-howix091	67	15	RNA	RNA	NNP
cord-000180-howix091	67	16	was	be	VBD
cord-000180-howix091	67	17	re	re	VBN
cord-000180-howix091	67	18	-	-	VBN
cord-000180-howix091	67	19	purified	purify	VBN
cord-000180-howix091	67	20	with	with	IN
cord-000180-howix091	67	21	TRI	TRI	NNP
cord-000180-howix091	67	22	reagent	reagent	NN
cord-000180-howix091	67	23	.	.	.
cord-000180-howix091	68	1	cDNA	cDNA	NNP
cord-000180-howix091	68	2	was	be	VBD
cord-000180-howix091	68	3	derived	derive	VBN
cord-000180-howix091	68	4	from	from	IN
cord-000180-howix091	68	5	30	30	CD
cord-000180-howix091	68	6	mg	mg	NNP
cord-000180-howix091	68	7	total	total	NN
cord-000180-howix091	68	8	RNA	RNA	NNP
cord-000180-howix091	68	9	using	use	VBG
cord-000180-howix091	68	10	anchored	anchor	VBN
cord-000180-howix091	68	11	oligo	oligo	NNP
cord-000180-howix091	68	12	(	(	-LRB-
cord-000180-howix091	68	13	dT)20	dT)20	NNP
cord-000180-howix091	68	14	primers	primer	NNS
cord-000180-howix091	68	15	(	(	-LRB-
cord-000180-howix091	68	16	Invitrogen	Invitrogen	NNP
cord-000180-howix091	68	17	)	)	-RRB-
cord-000180-howix091	68	18	as	as	IN
cord-000180-howix091	68	19	described	describe	VBN
cord-000180-howix091	68	20	in	in	IN
cord-000180-howix091	68	21	the	the	DT
cord-000180-howix091	68	22	manufacturer	manufacturer	NN
cord-000180-howix091	68	23	's	's	POS
cord-000180-howix091	68	24	instructions	instruction	NNS
cord-000180-howix091	68	25	.	.	.
cord-000180-howix091	69	1	For	for	IN
cord-000180-howix091	69	2	each	each	DT
cord-000180-howix091	69	3	entry	entry	NN
cord-000180-howix091	69	4	-	-	HYPH
cord-000180-howix091	69	5	defective	defective	JJ
cord-000180-howix091	69	6	HSV-1	HSV-1	NNP
cord-000180-howix091	69	7	mutant	mutant	JJ
cord-000180-howix091	69	8	,	,	,
cord-000180-howix091	69	9	the	the	DT
cord-000180-howix091	69	10	cDNA	cdna	NN
cord-000180-howix091	69	11	from	from	IN
cord-000180-howix091	69	12	three	three	CD
cord-000180-howix091	69	13	independent	independent	JJ
cord-000180-howix091	69	14	infections	infection	NNS
cord-000180-howix091	69	15	were	be	VBD
cord-000180-howix091	69	16	used	use	VBN
cord-000180-howix091	69	17	in	in	IN
cord-000180-howix091	69	18	technical	technical	JJ
cord-000180-howix091	69	19	triplicates	triplicate	NNS
cord-000180-howix091	69	20	for	for	IN
cord-000180-howix091	69	21	real	real	JJ
cord-000180-howix091	69	22	-	-	HYPH
cord-000180-howix091	69	23	time	time	NN
cord-000180-howix091	69	24	PCR	PCR	NNP
cord-000180-howix091	69	25	reactions	reaction	NNS
cord-000180-howix091	69	26	.	.	.
cord-000180-howix091	70	1	Microarray	Microarray	NNP
cord-000180-howix091	70	2	analysis	analysis	NN
cord-000180-howix091	70	3	was	be	VBD
cord-000180-howix091	70	4	carried	carry	VBN
cord-000180-howix091	70	5	out	out	RP
cord-000180-howix091	70	6	using	use	VBG
cord-000180-howix091	70	7	the	the	DT
cord-000180-howix091	70	8	Signal	Signal	NNP
cord-000180-howix091	70	9	Transduction	Transduction	NNP
cord-000180-howix091	70	10	PathwayFinder	PathwayFinder	NNP
cord-000180-howix091	70	11	cDNA	cdna	NN
cord-000180-howix091	70	12	array	array	NN
cord-000180-howix091	70	13	as	as	IN
cord-000180-howix091	70	14	per	per	IN
cord-000180-howix091	70	15	the	the	DT
cord-000180-howix091	70	16	manufacturer	manufacturer	NN
cord-000180-howix091	70	17	's	's	POS
cord-000180-howix091	70	18	instructions	instruction	NNS
cord-000180-howix091	70	19	(	(	-LRB-
cord-000180-howix091	70	20	Superarray	Superarray	NNP
cord-000180-howix091	70	21	)	)	-RRB-
cord-000180-howix091	70	22	.	.	.
cord-000180-howix091	71	1	Nylon	nylon	NN
cord-000180-howix091	71	2	cDNA	cdna	NN
cord-000180-howix091	71	3	microarrays	microarray	NNS
cord-000180-howix091	71	4	membranes	membrane	NNS
cord-000180-howix091	71	5	were	be	VBD
cord-000180-howix091	71	6	pre	pre	JJ
cord-000180-howix091	71	7	-	-	JJ
cord-000180-howix091	71	8	hybridised	hybridised	JJ
cord-000180-howix091	71	9	with	with	IN
cord-000180-howix091	71	10	supplied	supply	VBN
cord-000180-howix091	71	11	sheared	sheared	JJ
cord-000180-howix091	71	12	salmon	salmon	NN
cord-000180-howix091	71	13	sperm	sperm	NN
cord-000180-howix091	71	14	DNA	dna	NN
cord-000180-howix091	71	15	at	at	IN
cord-000180-howix091	71	16	60uC	60uc	CD
cord-000180-howix091	71	17	for	for	IN
cord-000180-howix091	71	18	one	one	CD
cord-000180-howix091	71	19	to	to	TO
cord-000180-howix091	71	20	two	two	CD
cord-000180-howix091	71	21	hours	hour	NNS
cord-000180-howix091	71	22	.	.	.
cord-000180-howix091	72	1	The	the	DT
cord-000180-howix091	72	2	pre	pre	JJ
cord-000180-howix091	72	3	-	-	JJ
cord-000180-howix091	72	4	hybridisation	hybridisation	JJ
cord-000180-howix091	72	5	solution	solution	NN
cord-000180-howix091	72	6	was	be	VBD
cord-000180-howix091	72	7	replaced	replace	VBN
cord-000180-howix091	72	8	with	with	IN
cord-000180-howix091	72	9	the	the	DT
cord-000180-howix091	72	10	biotin	biotin	NN
cord-000180-howix091	72	11	-	-	HYPH
cord-000180-howix091	72	12	dUTP	dutp	JJ
cord-000180-howix091	72	13	labelled	label	VBN
cord-000180-howix091	72	14	cDNA	cdna	NN
cord-000180-howix091	72	15	probe	probe	NN
cord-000180-howix091	72	16	,	,	,
cord-000180-howix091	72	17	which	which	WDT
cord-000180-howix091	72	18	was	be	VBD
cord-000180-howix091	72	19	diluted	dilute	VBN
cord-000180-howix091	72	20	in	in	IN
cord-000180-howix091	72	21	sheared	shear	VBN
cord-000180-howix091	72	22	salmon	salmon	NN
cord-000180-howix091	72	23	sperm	sperm	NN
cord-000180-howix091	72	24	DNA	DNA	NNP
cord-000180-howix091	72	25	.	.	.
cord-000180-howix091	73	1	The	the	DT
cord-000180-howix091	73	2	solution	solution	NN
cord-000180-howix091	73	3	was	be	VBD
cord-000180-howix091	73	4	left	leave	VBN
cord-000180-howix091	73	5	to	to	TO
cord-000180-howix091	73	6	hybridise	hybridise	VB
cord-000180-howix091	73	7	at	at	IN
cord-000180-howix091	73	8	60uC	60uc	CD
cord-000180-howix091	73	9	overnight	overnight	RB
cord-000180-howix091	73	10	.	.	.
cord-000180-howix091	74	1	The	the	DT
cord-000180-howix091	74	2	following	following	JJ
cord-000180-howix091	74	3	morning	morning	NN
cord-000180-howix091	74	4	the	the	DT
cord-000180-howix091	74	5	cDNA	cdna	NN
cord-000180-howix091	74	6	probe	probe	NN
cord-000180-howix091	74	7	was	be	VBD
cord-000180-howix091	74	8	discarded	discard	VBN
cord-000180-howix091	74	9	and	and	CC
cord-000180-howix091	74	10	the	the	DT
cord-000180-howix091	74	11	membrane	membrane	NN
cord-000180-howix091	74	12	was	be	VBD
cord-000180-howix091	74	13	washed	wash	VBN
cord-000180-howix091	74	14	twice	twice	RB
cord-000180-howix091	74	15	then	then	RB
cord-000180-howix091	74	16	blocked	block	VBN
cord-000180-howix091	74	17	in	in	IN
cord-000180-howix091	74	18	Solution	Solution	NNP
cord-000180-howix091	74	19	Q	Q	NNP
cord-000180-howix091	74	20	,	,	,
cord-000180-howix091	74	21	as	as	IN
cord-000180-howix091	74	22	provided	provide	VBN
cord-000180-howix091	74	23	by	by	IN
cord-000180-howix091	74	24	the	the	DT
cord-000180-howix091	74	25	manufacturer	manufacturer	NN
cord-000180-howix091	74	26	.	.	.
cord-000180-howix091	75	1	After	after	IN
cord-000180-howix091	75	2	40	40	CD
cord-000180-howix091	75	3	minutes	minute	NNS
cord-000180-howix091	75	4	,	,	,
cord-000180-howix091	75	5	the	the	DT
cord-000180-howix091	75	6	blocking	block	VBG
cord-000180-howix091	75	7	solution	solution	NN
cord-000180-howix091	75	8	was	be	VBD
cord-000180-howix091	75	9	discarded	discard	VBN
cord-000180-howix091	75	10	and	and	CC
cord-000180-howix091	75	11	the	the	DT
cord-000180-howix091	75	12	membrane	membrane	NN
cord-000180-howix091	75	13	was	be	VBD
cord-000180-howix091	75	14	incubated	incubate	VBN
cord-000180-howix091	75	15	with	with	IN
cord-000180-howix091	75	16	a	a	DT
cord-000180-howix091	75	17	binding	binding	JJ
cord-000180-howix091	75	18	buffer	buffer	NN
cord-000180-howix091	75	19	,	,	,
cord-000180-howix091	75	20	Solution	Solution	NNP
cord-000180-howix091	75	21	F.	F.	NNP
cord-000180-howix091	76	1	After	after	IN
cord-000180-howix091	76	2	washing	washing	NN
cord-000180-howix091	76	3	,	,	,
cord-000180-howix091	76	4	the	the	DT
cord-000180-howix091	76	5	chemiluminescent	chemiluminescent	NN
cord-000180-howix091	76	6	substrate	substrate	NN
cord-000180-howix091	76	7	was	be	VBD
cord-000180-howix091	76	8	incubated	incubate	VBN
cord-000180-howix091	76	9	with	with	IN
cord-000180-howix091	76	10	the	the	DT
cord-000180-howix091	76	11	membrane	membrane	NN
cord-000180-howix091	76	12	for	for	IN
cord-000180-howix091	76	13	two	two	CD
cord-000180-howix091	76	14	to	to	TO
cord-000180-howix091	76	15	five	five	CD
cord-000180-howix091	76	16	minutes	minute	NNS
cord-000180-howix091	76	17	at	at	IN
cord-000180-howix091	76	18	room	room	NN
cord-000180-howix091	76	19	temperature	temperature	NN
cord-000180-howix091	76	20	.	.	.
cord-000180-howix091	77	1	The	the	DT
cord-000180-howix091	77	2	microarray	microarray	NN
cord-000180-howix091	77	3	membrane	membrane	NN
cord-000180-howix091	77	4	was	be	VBD
cord-000180-howix091	77	5	then	then	RB
cord-000180-howix091	77	6	exposed	expose	VBN
cord-000180-howix091	77	7	to	to	IN
cord-000180-howix091	77	8	X	x	NN
cord-000180-howix091	77	9	-	-	NN
cord-000180-howix091	77	10	ray	ray	JJ
cord-000180-howix091	77	11	film	film	NN
cord-000180-howix091	77	12	.	.	.
cord-000180-howix091	78	1	Analysis	analysis	NN
cord-000180-howix091	78	2	was	be	VBD
cord-000180-howix091	78	3	performed	perform	VBN
cord-000180-howix091	78	4	using	use	VBG
cord-000180-howix091	78	5	GEArray	GEArray	NNP
cord-000180-howix091	78	6	Expression	Expression	NNP
cord-000180-howix091	78	7	Analysis	Analysis	NNP
cord-000180-howix091	78	8	Suite	Suite	NNP
cord-000180-howix091	78	9	as	as	IN
cord-000180-howix091	78	10	provided	provide	VBN
cord-000180-howix091	78	11	by	by	IN
cord-000180-howix091	78	12	the	the	DT
cord-000180-howix091	78	13	manufacturer	manufacturer	NN
cord-000180-howix091	78	14	(	(	-LRB-
cord-000180-howix091	78	15	Superarray	Superarray	NNP
cord-000180-howix091	78	16	)	)	-RRB-
cord-000180-howix091	78	17	.	.	.
cord-000180-howix091	79	1	All	all	PDT
cord-000180-howix091	79	2	the	the	DT
cord-000180-howix091	79	3	data	data	NN
cord-000180-howix091	79	4	sets	set	NNS
cord-000180-howix091	79	5	used	use	VBN
cord-000180-howix091	79	6	in	in	IN
cord-000180-howix091	79	7	the	the	DT
cord-000180-howix091	79	8	microarray	microarray	NN
cord-000180-howix091	79	9	analysis	analysis	NN
cord-000180-howix091	79	10	are	be	VBP
cord-000180-howix091	79	11	available	available	JJ
cord-000180-howix091	79	12	in	in	IN
cord-000180-howix091	79	13	Table	Table	NNP
cord-000180-howix091	79	14	S1	S1	NNP
cord-000180-howix091	79	15	.	.	.
cord-000180-howix091	79	16	cDNA	cDNA	NNP
cord-000180-howix091	79	17	derived	derive	VBN
cord-000180-howix091	79	18	from	from	IN
cord-000180-howix091	79	19	cells	cell	NNS
cord-000180-howix091	79	20	that	that	WDT
cord-000180-howix091	79	21	were	be	VBD
cord-000180-howix091	79	22	mock	mock	JJ
cord-000180-howix091	79	23	-	-	HYPH
cord-000180-howix091	79	24	infected	infect	VBN
cord-000180-howix091	79	25	or	or	CC
cord-000180-howix091	79	26	inoculated	inoculate	VBN
cord-000180-howix091	79	27	with	with	IN
cord-000180-howix091	79	28	1000	1000	CD
cord-000180-howix091	79	29	particles	particle	NNS
cord-000180-howix091	79	30	/	/	SYM
cord-000180-howix091	79	31	cell	cell	NN
cord-000180-howix091	79	32	of	of	IN
cord-000180-howix091	79	33	entry	entry	NN
cord-000180-howix091	79	34	-	-	HYPH
cord-000180-howix091	79	35	defective	defective	JJ
cord-000180-howix091	79	36	DgB	dgb	NN
cord-000180-howix091	79	37	,	,	,
cord-000180-howix091	79	38	DgD	dgd	NN
cord-000180-howix091	79	39	and	and	CC
cord-000180-howix091	79	40	DgH	dgh	NN
cord-000180-howix091	79	41	virions	virion	NNS
cord-000180-howix091	79	42	was	be	VBD
cord-000180-howix091	79	43	used	use	VBN
cord-000180-howix091	79	44	for	for	IN
cord-000180-howix091	79	45	real	real	JJ
cord-000180-howix091	79	46	-	-	HYPH
cord-000180-howix091	79	47	time	time	NN
cord-000180-howix091	79	48	PCR	PCR	NNP
cord-000180-howix091	79	49	analysis	analysis	NN
cord-000180-howix091	79	50	.	.	.
cord-000180-howix091	80	1	Primers	primer	NNS
cord-000180-howix091	80	2	were	be	VBD
cord-000180-howix091	80	3	designed	design	VBN
cord-000180-howix091	80	4	,	,	,
cord-000180-howix091	80	5	using	use	VBG
cord-000180-howix091	80	6	the	the	DT
cord-000180-howix091	80	7	Primer3	Primer3	NNP
cord-000180-howix091	80	8	software	software	NN
cord-000180-howix091	80	9	[	[	-LRB-
cord-000180-howix091	80	10	23	23	CD
cord-000180-howix091	80	11	]	]	-RRB-
cord-000180-howix091	80	12	,	,	,
cord-000180-howix091	80	13	to	to	TO
cord-000180-howix091	80	14	anneal	anneal	VB
cord-000180-howix091	80	15	at	at	IN
cord-000180-howix091	80	16	60uC	60uc	CD
cord-000180-howix091	80	17	,	,	,
cord-000180-howix091	80	18	with	with	IN
cord-000180-howix091	80	19	a	a	DT
cord-000180-howix091	80	20	minimum	minimum	JJ
cord-000180-howix091	80	21	product	product	NN
cord-000180-howix091	80	22	melting	melting	NN
cord-000180-howix091	80	23	temperature	temperature	NN
cord-000180-howix091	80	24	of	of	IN
cord-000180-howix091	80	25	80uC	80uc	CD
cord-000180-howix091	80	26	(	(	-LRB-
cord-000180-howix091	80	27	Table	Table	NNP
cord-000180-howix091	80	28	S2	S2	NNP
cord-000180-howix091	80	29	)	)	-RRB-
cord-000180-howix091	80	30	.	.	.
cord-000180-howix091	81	1	Reactions	reaction	NNS
cord-000180-howix091	81	2	were	be	VBD
cord-000180-howix091	81	3	set	set	VBN
cord-000180-howix091	81	4	-	-	HYPH
cord-000180-howix091	81	5	up	up	NN
cord-000180-howix091	81	6	with	with	IN
cord-000180-howix091	81	7	cDNA	cdna	NN
cord-000180-howix091	81	8	corresponding	correspond	VBG
cord-000180-howix091	81	9	to	to	IN
cord-000180-howix091	81	10	100	100	CD
cord-000180-howix091	81	11	ng	ng	NNP
cord-000180-howix091	81	12	total	total	NN
cord-000180-howix091	81	13	RNA	RNA	NNP
cord-000180-howix091	81	14	,	,	,
cord-000180-howix091	81	15	primers	primer	NNS
cord-000180-howix091	81	16	(	(	-LRB-
cord-000180-howix091	81	17	70	70	CD
cord-000180-howix091	81	18	nM	nM	NNP
cord-000180-howix091	81	19	)	)	-RRB-
cord-000180-howix091	81	20	,	,	,
cord-000180-howix091	81	21	and	and	CC
cord-000180-howix091	81	22	10	10	CD
cord-000180-howix091	81	23	ml	ml	NNS
cord-000180-howix091	81	24	SYBR	SYBR	NNP
cord-000180-howix091	81	25	Green	Green	NNP
cord-000180-howix091	81	26	PCR	PCR	NNP
cord-000180-howix091	81	27	master	master	NN
cord-000180-howix091	81	28	mix	mix	NN
cord-000180-howix091	81	29	(	(	-LRB-
cord-000180-howix091	81	30	Abgene	Abgene	NNP
cord-000180-howix091	81	31	)	)	-RRB-
cord-000180-howix091	81	32	made	make	VBD
cord-000180-howix091	81	33	to	to	IN
cord-000180-howix091	81	34	a	a	DT
cord-000180-howix091	81	35	total	total	JJ
cord-000180-howix091	81	36	volume	volume	NN
cord-000180-howix091	81	37	of	of	IN
cord-000180-howix091	81	38	20	20	CD
cord-000180-howix091	81	39	ml	ml	NNS
cord-000180-howix091	81	40	with	with	IN
cord-000180-howix091	81	41	nuclease	nuclease	NN
cord-000180-howix091	81	42	-	-	HYPH
cord-000180-howix091	81	43	free	free	JJ
cord-000180-howix091	81	44	dH	dh	NN
cord-000180-howix091	81	45	2	2	CD
cord-000180-howix091	82	1	O.	O.	NNP
cord-000180-howix091	82	2	A	A	NNP
cord-000180-howix091	83	1	Corbett	Corbett	NNP
cord-000180-howix091	83	2	Rotorgene	Rotorgene	NNP
cord-000180-howix091	83	3	3000	3000	CD
cord-000180-howix091	83	4	was	be	VBD
cord-000180-howix091	83	5	used	use	VBN
cord-000180-howix091	83	6	to	to	TO
cord-000180-howix091	83	7	determine	determine	VB
cord-000180-howix091	83	8	the	the	DT
cord-000180-howix091	83	9	levels	level	NNS
cord-000180-howix091	83	10	of	of	IN
cord-000180-howix091	83	11	SYBR	SYBR	NNP
cord-000180-howix091	83	12	green	green	JJ
cord-000180-howix091	83	13	fluorescence	fluorescence	NN
cord-000180-howix091	83	14	over	over	IN
cord-000180-howix091	83	15	40	40	CD
cord-000180-howix091	83	16	cycles	cycle	NNS
cord-000180-howix091	83	17	.	.	.
cord-000180-howix091	84	1	Samples	sample	NNS
cord-000180-howix091	84	2	were	be	VBD
cord-000180-howix091	84	3	denatured	denature	VBN
cord-000180-howix091	84	4	for	for	IN
cord-000180-howix091	84	5	10	10	CD
cord-000180-howix091	84	6	minutes	minute	NNS
cord-000180-howix091	84	7	at	at	IN
cord-000180-howix091	84	8	95uC	95uc	CD
cord-000180-howix091	84	9	,	,	,
cord-000180-howix091	84	10	annealed	anneal	VBN
cord-000180-howix091	84	11	at	at	IN
cord-000180-howix091	84	12	60uC	60uc	CD
cord-000180-howix091	84	13	for	for	IN
cord-000180-howix091	84	14	30	30	CD
cord-000180-howix091	84	15	seconds	second	NNS
cord-000180-howix091	84	16	,	,	,
cord-000180-howix091	84	17	with	with	IN
cord-000180-howix091	84	18	extension	extension	NN
cord-000180-howix091	84	19	of	of	IN
cord-000180-howix091	84	20	the	the	DT
cord-000180-howix091	84	21	primer	primer	NN
cord-000180-howix091	84	22	product	product	NN
cord-000180-howix091	84	23	at	at	IN
cord-000180-howix091	84	24	72uC	72uc	CD
cord-000180-howix091	84	25	for	for	IN
cord-000180-howix091	84	26	40	40	CD
cord-000180-howix091	84	27	seconds	second	NNS
cord-000180-howix091	84	28	then	then	RB
cord-000180-howix091	84	29	a	a	DT
cord-000180-howix091	84	30	final	final	JJ
cord-000180-howix091	84	31	80uC	80uc	CD
cord-000180-howix091	84	32	step	step	NN
cord-000180-howix091	84	33	for	for	IN
cord-000180-howix091	84	34	20	20	CD
cord-000180-howix091	84	35	seconds	second	NNS
cord-000180-howix091	84	36	that	that	WDT
cord-000180-howix091	84	37	removes	remove	VBZ
cord-000180-howix091	84	38	background	background	NN
cord-000180-howix091	84	39	fluorescence	fluorescence	NN
cord-000180-howix091	84	40	from	from	IN
cord-000180-howix091	84	41	primer	primer	NN
cord-000180-howix091	84	42	-	-	NNS
cord-000180-howix091	84	43	dimers	dimer	NNS
cord-000180-howix091	84	44	.	.	.
cord-000180-howix091	85	1	A	a	DT
cord-000180-howix091	85	2	melt	melt	NN
cord-000180-howix091	85	3	curve	curve	NN
cord-000180-howix091	85	4	analysis	analysis	NN
cord-000180-howix091	85	5	was	be	VBD
cord-000180-howix091	85	6	produced	produce	VBN
cord-000180-howix091	85	7	at	at	IN
cord-000180-howix091	85	8	the	the	DT
cord-000180-howix091	85	9	end	end	NN
cord-000180-howix091	85	10	of	of	IN
cord-000180-howix091	85	11	the	the	DT
cord-000180-howix091	85	12	cycling	cycling	NN
cord-000180-howix091	85	13	to	to	TO
cord-000180-howix091	85	14	ensure	ensure	VB
cord-000180-howix091	85	15	the	the	DT
cord-000180-howix091	85	16	specificity	specificity	NN
cord-000180-howix091	85	17	of	of	IN
cord-000180-howix091	85	18	PCR	PCR	NNP
cord-000180-howix091	85	19	product	product	NN
cord-000180-howix091	85	20	amplification	amplification	NN
cord-000180-howix091	85	21	and	and	CC
cord-000180-howix091	85	22	associated	associate	VBD
cord-000180-howix091	85	23	SYBR	SYBR	NNP
cord-000180-howix091	85	24	green	green	JJ
cord-000180-howix091	85	25	fluorescence	fluorescence	NN
cord-000180-howix091	85	26	.	.	.
cord-000180-howix091	86	1	Relative	relative	JJ
cord-000180-howix091	86	2	gene	gene	NN
cord-000180-howix091	86	3	expression	expression	NN
cord-000180-howix091	86	4	levels	level	NNS
cord-000180-howix091	86	5	between	between	IN
cord-000180-howix091	86	6	mockinoculated	mockinoculated	JJ
cord-000180-howix091	86	7	and	and	CC
cord-000180-howix091	86	8	inoculated	inoculate	VBN
cord-000180-howix091	86	9	cells	cell	NNS
cord-000180-howix091	86	10	were	be	VBD
cord-000180-howix091	86	11	calculated	calculate	VBN
cord-000180-howix091	86	12	using	use	VBG
cord-000180-howix091	86	13	the	the	DT
cord-000180-howix091	86	14	Pfaffl	Pfaffl	NNP
cord-000180-howix091	86	15	method	method	NN
cord-000180-howix091	86	16	with	with	IN
cord-000180-howix091	86	17	potential	potential	JJ
cord-000180-howix091	86	18	variations	variation	NNS
cord-000180-howix091	86	19	in	in	IN
cord-000180-howix091	86	20	cDNA	cdna	NN
cord-000180-howix091	86	21	quantity	quantity	NN
cord-000180-howix091	86	22	between	between	IN
cord-000180-howix091	86	23	samples	sample	NNS
cord-000180-howix091	86	24	normalised	normalise	VBN
cord-000180-howix091	86	25	to	to	IN
cord-000180-howix091	86	26	the	the	DT
cord-000180-howix091	86	27	transcript	transcript	NN
cord-000180-howix091	86	28	for	for	IN
cord-000180-howix091	86	29	ribosomal	ribosomal	JJ
cord-000180-howix091	86	30	protein	protein	NN
cord-000180-howix091	87	1	L13a	L13a	.
cord-000180-howix091	88	1	(	(	-LRB-
cord-000180-howix091	88	2	RPL13a	RPL13a	NNP
cord-000180-howix091	88	3	)	)	-RRB-
cord-000180-howix091	88	4	[	[	-LRB-
cord-000180-howix091	88	5	24	24	CD
cord-000180-howix091	88	6	]	]	-RRB-
cord-000180-howix091	88	7	.	.	.
cord-000180-howix091	89	1	Serial	serial	JJ
cord-000180-howix091	89	2	dilutions	dilution	NNS
cord-000180-howix091	89	3	of	of	IN
cord-000180-howix091	89	4	PCR	PCR	NNP
cord-000180-howix091	89	5	product	product	NN
cord-000180-howix091	89	6	across	across	IN
cord-000180-howix091	89	7	8	8	CD
cord-000180-howix091	89	8	logs	log	NNS
cord-000180-howix091	89	9	were	be	VBD
cord-000180-howix091	89	10	used	use	VBN
cord-000180-howix091	89	11	to	to	TO
cord-000180-howix091	89	12	determine	determine	VB
cord-000180-howix091	89	13	the	the	DT
cord-000180-howix091	89	14	efficiency	efficiency	NN
cord-000180-howix091	89	15	of	of	IN
cord-000180-howix091	89	16	PCR	PCR	NNP
cord-000180-howix091	89	17	amplification	amplification	NN
cord-000180-howix091	89	18	for	for	IN
cord-000180-howix091	89	19	each	each	DT
cord-000180-howix091	89	20	primer	primer	NN
cord-000180-howix091	89	21	set	set	VBN
cord-000180-howix091	89	22	under	under	IN
cord-000180-howix091	89	23	the	the	DT
cord-000180-howix091	89	24	above	above	JJ
cord-000180-howix091	89	25	conditions	condition	NNS
cord-000180-howix091	89	26	so	so	IN
cord-000180-howix091	89	27	that	that	IN
cord-000180-howix091	89	28	the	the	DT
cord-000180-howix091	89	29	relative	relative	JJ
cord-000180-howix091	89	30	quantitation	quantitation	NN
cord-000180-howix091	89	31	could	could	MD
cord-000180-howix091	89	32	be	be	VB
cord-000180-howix091	89	33	adjusted	adjust	VBN
cord-000180-howix091	89	34	as	as	IN
cord-000180-howix091	89	35	defined	define	VBN
cord-000180-howix091	89	36	by	by	IN
cord-000180-howix091	89	37	the	the	DT
cord-000180-howix091	89	38	Pfaffl	Pfaffl	NNP
cord-000180-howix091	89	39	method	method	NN
cord-000180-howix091	89	40	.	.	.
cord-000180-howix091	90	1	A	a	DT
cord-000180-howix091	90	2	relative	relative	JJ
cord-000180-howix091	90	3	change	change	NN
cord-000180-howix091	90	4	in	in	IN
cord-000180-howix091	90	5	expression	expression	NN
cord-000180-howix091	90	6	of	of	IN
cord-000180-howix091	90	7	two	two	CD
cord-000180-howix091	90	8	-	-	HYPH
cord-000180-howix091	90	9	fold	fold	NN
cord-000180-howix091	90	10	was	be	VBD
cord-000180-howix091	90	11	set	set	VBN
cord-000180-howix091	90	12	as	as	IN
cord-000180-howix091	90	13	a	a	DT
cord-000180-howix091	90	14	threshold	threshold	NN
cord-000180-howix091	90	15	for	for	IN
cord-000180-howix091	90	16	determining	determine	VBG
cord-000180-howix091	90	17	whether	whether	IN
cord-000180-howix091	90	18	differential	differential	JJ
cord-000180-howix091	90	19	expression	expression	NN
cord-000180-howix091	90	20	of	of	IN
cord-000180-howix091	90	21	a	a	DT
cord-000180-howix091	90	22	gene	gene	NN
cord-000180-howix091	90	23	had	have	VBD
cord-000180-howix091	90	24	occurred	occur	VBN
cord-000180-howix091	90	25	.	.	.
cord-000180-howix091	91	1	The	the	DT
cord-000180-howix091	91	2	p	p	NN
cord-000180-howix091	91	3	values	value	NNS
cord-000180-howix091	91	4	associated	associate	VBN
cord-000180-howix091	91	5	with	with	IN
cord-000180-howix091	91	6	the	the	DT
cord-000180-howix091	91	7	fold	fold	JJ
cord-000180-howix091	91	8	-	-	HYPH
cord-000180-howix091	91	9	change	change	NN
cord-000180-howix091	91	10	in	in	IN
cord-000180-howix091	91	11	expression	expression	NN
cord-000180-howix091	91	12	were	be	VBD
cord-000180-howix091	91	13	calculated	calculate	VBN
cord-000180-howix091	91	14	using	use	VBG
cord-000180-howix091	91	15	a	a	DT
cord-000180-howix091	91	16	Students	Students	NNP
cord-000180-howix091	91	17	t	t	NN
cord-000180-howix091	91	18	-	-	HYPH
cord-000180-howix091	91	19	test	test	NN
cord-000180-howix091	91	20	on	on	IN
cord-000180-howix091	91	21	the	the	DT
cord-000180-howix091	91	22	realtime	realtime	NN
cord-000180-howix091	91	23	PCR	pcr	NN
cord-000180-howix091	91	24	C	c	NN
cord-000180-howix091	91	25	T	t	NN
cord-000180-howix091	91	26	values	value	NNS
cord-000180-howix091	91	27	comparing	compare	VBG
cord-000180-howix091	91	28	triplicate	triplicate	JJ
cord-000180-howix091	91	29	mock	mock	RB
cord-000180-howix091	91	30	-	-	HYPH
cord-000180-howix091	91	31	inoculated	inoculate	VBN
cord-000180-howix091	91	32	and	and	CC
cord-000180-howix091	91	33	HSV	HSV	NNP
cord-000180-howix091	91	34	inoculated	inoculate	VBD
cord-000180-howix091	91	35	cells	cell	NNS
cord-000180-howix091	91	36	.	.	.
cord-000180-howix091	92	1	An	an	DT
cord-000180-howix091	92	2	NF	NF	NNP
cord-000180-howix091	92	3	-	-	HYPH
cord-000180-howix091	92	4	kB	kb	CD
cord-000180-howix091	92	5	reporter	reporter	NN
cord-000180-howix091	92	6	assay	assay	NN
cord-000180-howix091	92	7	system	system	NN
cord-000180-howix091	92	8	was	be	VBD
cord-000180-howix091	92	9	designed	design	VBN
cord-000180-howix091	92	10	using	use	VBG
cord-000180-howix091	92	11	a	a	DT
cord-000180-howix091	92	12	pGL4-NFkB	pGL4-NFkB	NNP
cord-000180-howix091	92	13	construct	construct	NN
cord-000180-howix091	92	14	(	(	-LRB-
cord-000180-howix091	92	15	Promega	Promega	NNP
cord-000180-howix091	92	16	)	)	-RRB-
cord-000180-howix091	92	17	.	.	.
cord-000180-howix091	93	1	Quadruplicate	Quadruplicate	NNP
cord-000180-howix091	93	2	repeats	repeat	VBZ
cord-000180-howix091	93	3	of	of	IN
cord-000180-howix091	93	4	the	the	DT
cord-000180-howix091	93	5	NF	NF	NNP
cord-000180-howix091	93	6	-	-	HYPH
cord-000180-howix091	93	7	kB	kB	NNP
cord-000180-howix091	93	8	binding	bind	VBG
cord-000180-howix091	93	9	consensus	consensus	NN
cord-000180-howix091	93	10	sequence	sequence	NN
cord-000180-howix091	93	11	59-GGGAATTTCC-39	59-GGGAATTTCC-39	NNP
cord-000180-howix091	93	12	were	be	VBD
cord-000180-howix091	93	13	excised	excise	VBN
cord-000180-howix091	93	14	from	from	IN
cord-000180-howix091	93	15	a	a	DT
cord-000180-howix091	93	16	p	p	NN
cord-000180-howix091	93	17	-	-	HYPH
cord-000180-howix091	93	18	NF	nf	NN
cord-000180-howix091	93	19	-	-	HYPH
cord-000180-howix091	93	20	kB	kB	NNP
cord-000180-howix091	93	21	-	-	HYPH
cord-000180-howix091	93	22	Luc	Luc	NNP
cord-000180-howix091	93	23	(	(	-LRB-
cord-000180-howix091	93	24	Gift	Gift	NNP
cord-000180-howix091	93	25	from	from	IN
cord-000180-howix091	93	26	Dr.	Dr.	NNP
cord-000180-howix091	93	27	Heike	Heike	NNP
cord-000180-howix091	93	28	Laman	Laman	NNP
cord-000180-howix091	93	29	,	,	,
cord-000180-howix091	93	30	University	University	NNP
cord-000180-howix091	93	31	of	of	IN
cord-000180-howix091	93	32	Cambridge	Cambridge	NNP
cord-000180-howix091	93	33	)	)	-RRB-
cord-000180-howix091	93	34	vector	vector	NN
cord-000180-howix091	93	35	using	use	VBG
cord-000180-howix091	93	36	KpnI	KpnI	NNP
cord-000180-howix091	93	37	and	and	CC
cord-000180-howix091	93	38	HindIII	HindIII	NNPS
cord-000180-howix091	93	39	and	and	CC
cord-000180-howix091	93	40	ligated	ligate	VBD
cord-000180-howix091	93	41	into	into	IN
cord-000180-howix091	93	42	the	the	DT
cord-000180-howix091	93	43	pGL4.20	pGL4.20	NNP
cord-000180-howix091	93	44	vector	vector	NN
cord-000180-howix091	93	45	multiple	multiple	JJ
cord-000180-howix091	93	46	cloning	cloning	NN
cord-000180-howix091	93	47	site	site	NN
cord-000180-howix091	93	48	using	use	VBG
cord-000180-howix091	93	49	the	the	DT
cord-000180-howix091	93	50	same	same	JJ
cord-000180-howix091	93	51	restriction	restriction	NN
cord-000180-howix091	93	52	sites	site	NNS
cord-000180-howix091	93	53	.	.	.
cord-000180-howix091	94	1	pGL4.20	pGL4.20	NNP
cord-000180-howix091	94	2	was	be	VBD
cord-000180-howix091	94	3	chosen	choose	VBN
cord-000180-howix091	94	4	as	as	IN
cord-000180-howix091	94	5	it	-PRON-	PRP
cord-000180-howix091	94	6	is	be	VBZ
cord-000180-howix091	94	7	optimized	optimize	VBN
cord-000180-howix091	94	8	for	for	IN
cord-000180-howix091	94	9	more	more	RBR
cord-000180-howix091	94	10	efficient	efficient	JJ
cord-000180-howix091	94	11	expression	expression	NN
cord-000180-howix091	94	12	in	in	IN
cord-000180-howix091	94	13	mammalian	mammalian	JJ
cord-000180-howix091	94	14	cells	cell	NNS
cord-000180-howix091	94	15	,	,	,
cord-000180-howix091	94	16	compared	compare	VBN
cord-000180-howix091	94	17	to	to	IN
cord-000180-howix091	94	18	previous	previous	JJ
cord-000180-howix091	94	19	generations	generation	NNS
cord-000180-howix091	94	20	of	of	IN
cord-000180-howix091	94	21	luciferase	luciferase	NN
cord-000180-howix091	94	22	constructs	construct	NNS
cord-000180-howix091	94	23	,	,	,
cord-000180-howix091	94	24	and	and	CC
cord-000180-howix091	94	25	contains	contain	VBZ
cord-000180-howix091	94	26	fewer	few	JJR
cord-000180-howix091	94	27	transcription	transcription	NN
cord-000180-howix091	94	28	factor	factor	NN
cord-000180-howix091	94	29	consensus	consensus	NN
cord-000180-howix091	94	30	sequences	sequence	NNS
cord-000180-howix091	94	31	such	such	JJ
cord-000180-howix091	94	32	that	that	DT
cord-000180-howix091	94	33	background	background	NN
cord-000180-howix091	94	34	luciferase	luciferase	NN
cord-000180-howix091	94	35	expression	expression	NN
cord-000180-howix091	94	36	is	be	VBZ
cord-000180-howix091	94	37	reduced	reduce	VBN
cord-000180-howix091	94	38	.	.	.
cord-000180-howix091	95	1	HFFs	HFFs	NNP
cord-000180-howix091	95	2	were	be	VBD
cord-000180-howix091	95	3	electroporated	electroporate	VBN
cord-000180-howix091	95	4	in	in	IN
cord-000180-howix091	95	5	batches	batch	NNS
cord-000180-howix091	95	6	of	of	IN
cord-000180-howix091	95	7	6610	6610	CD
cord-000180-howix091	95	8	5	5	CD
cord-000180-howix091	95	9	cells	cell	NNS
cord-000180-howix091	95	10	per	per	IN
cord-000180-howix091	95	11	cuvet	cuvet	NNS
cord-000180-howix091	95	12	(	(	-LRB-
cord-000180-howix091	95	13	Amaxa	Amaxa	NNP
cord-000180-howix091	95	14	)	)	-RRB-
cord-000180-howix091	95	15	with	with	IN
cord-000180-howix091	95	16	2	2	CD
cord-000180-howix091	95	17	mg	mg	NN
cord-000180-howix091	95	18	of	of	IN
cord-000180-howix091	95	19	pGL4-NF	pGL4-NF	NNP
cord-000180-howix091	95	20	-	-	HYPH
cord-000180-howix091	95	21	kB	kB	NNP
cord-000180-howix091	95	22	,	,	,
cord-000180-howix091	95	23	pooled	pool	VBN
cord-000180-howix091	95	24	together	together	RB
cord-000180-howix091	95	25	and	and	CC
cord-000180-howix091	95	26	aliquoted	aliquote	VBD
cord-000180-howix091	95	27	at	at	IN
cord-000180-howix091	95	28	10	10	CD
cord-000180-howix091	95	29	5	5	CD
cord-000180-howix091	95	30	cells	cell	NNS
cord-000180-howix091	95	31	per	per	IN
cord-000180-howix091	95	32	well	well	NN
cord-000180-howix091	95	33	of	of	IN
cord-000180-howix091	95	34	a	a	DT
cord-000180-howix091	95	35	24-well	24-well	CD
cord-000180-howix091	95	36	plate	plate	NN
cord-000180-howix091	95	37	.	.	.
cord-000180-howix091	96	1	After	after	IN
cord-000180-howix091	96	2	48-hours	48-hours	CD
cord-000180-howix091	96	3	recovery	recovery	NN
cord-000180-howix091	96	4	in	in	IN
cord-000180-howix091	96	5	supplemented	supplement	VBN
cord-000180-howix091	96	6	media	medium	NNS
cord-000180-howix091	96	7	,	,	,
cord-000180-howix091	96	8	the	the	DT
cord-000180-howix091	96	9	transfected	transfecte	VBN
cord-000180-howix091	96	10	HFFs	hff	NNS
cord-000180-howix091	96	11	were	be	VBD
cord-000180-howix091	96	12	serum	serum	NN
cord-000180-howix091	96	13	-	-	HYPH
cord-000180-howix091	96	14	starved	starve	VBN
cord-000180-howix091	96	15	for	for	IN
cord-000180-howix091	96	16	five	five	CD
cord-000180-howix091	96	17	days	day	NNS
cord-000180-howix091	96	18	.	.	.
cord-000180-howix091	97	1	HFFs	HFFs	NNP
cord-000180-howix091	97	2	were	be	VBD
cord-000180-howix091	97	3	inoculated	inoculate	VBN
cord-000180-howix091	97	4	with	with	IN
cord-000180-howix091	97	5	1000	1000	CD
cord-000180-howix091	97	6	particles	particle	NNS
cord-000180-howix091	97	7	/	/	SYM
cord-000180-howix091	97	8	cell	cell	NN
cord-000180-howix091	97	9	of	of	IN
cord-000180-howix091	97	10	DgH	dgh	NN
cord-000180-howix091	97	11	HSV-1	hsv-1	NN
cord-000180-howix091	97	12	and	and	CC
cord-000180-howix091	97	13	were	be	VBD
cord-000180-howix091	97	14	lysed	lyse	VBN
cord-000180-howix091	97	15	at	at	IN
cord-000180-howix091	97	16	the	the	DT
cord-000180-howix091	97	17	indicated	indicate	VBN
cord-000180-howix091	97	18	time	time	NN
cord-000180-howix091	97	19	points	point	NNS
cord-000180-howix091	97	20	in	in	IN
cord-000180-howix091	97	21	100	100	CD
cord-000180-howix091	97	22	ml	ml	NN
cord-000180-howix091	97	23	passive	passive	JJ
cord-000180-howix091	97	24	lysis	lysis	NN
cord-000180-howix091	97	25	buffer	buffer	NN
cord-000180-howix091	97	26	(	(	-LRB-
cord-000180-howix091	97	27	Promega	Promega	NNP
cord-000180-howix091	97	28	)	)	-RRB-
cord-000180-howix091	97	29	and	and	CC
cord-000180-howix091	97	30	20	20	CD
cord-000180-howix091	97	31	ml	ml	NNS
cord-000180-howix091	97	32	of	of	IN
cord-000180-howix091	97	33	lysate	lysate	NN
cord-000180-howix091	97	34	were	be	VBD
cord-000180-howix091	97	35	examined	examine	VBN
cord-000180-howix091	97	36	for	for	IN
cord-000180-howix091	97	37	luciferase	luciferase	NN
cord-000180-howix091	97	38	activity	activity	NN
cord-000180-howix091	97	39	using	use	VBG
cord-000180-howix091	97	40	50	50	CD
cord-000180-howix091	97	41	ml	ml	NN
cord-000180-howix091	97	42	assay	assay	NN
cord-000180-howix091	97	43	buffer	buffer	NN
cord-000180-howix091	97	44	(	(	-LRB-
cord-000180-howix091	97	45	Promega	Promega	NNP
cord-000180-howix091	97	46	)	)	-RRB-
cord-000180-howix091	97	47	.	.	.
cord-000180-howix091	98	1	Western	Western	NNP
cord-000180-howix091	98	2	Blotting	Blotting	NNP
cord-000180-howix091	98	3	gD	gD	NNP
cord-000180-howix091	98	4	and	and	CC
cord-000180-howix091	98	5	the	the	DT
cord-000180-howix091	98	6	major	major	JJ
cord-000180-howix091	98	7	tegument	tegument	NN
cord-000180-howix091	98	8	protein	protein	NN
cord-000180-howix091	98	9	,	,	,
cord-000180-howix091	98	10	VP16	VP16	NNP
cord-000180-howix091	98	11	,	,	,
cord-000180-howix091	98	12	were	be	VBD
cord-000180-howix091	98	13	detected	detect	VBN
cord-000180-howix091	98	14	by	by	IN
cord-000180-howix091	98	15	immunoblotting	immunoblotte	VBG
cord-000180-howix091	98	16	using	use	VBG
cord-000180-howix091	98	17	the	the	DT
cord-000180-howix091	98	18	monoclonal	monoclonal	JJ
cord-000180-howix091	98	19	antibodies	antibody	NNS
cord-000180-howix091	98	20	LP2	LP2	NNP
cord-000180-howix091	98	21	and	and	CC
cord-000180-howix091	98	22	LP1	LP1	NNP
cord-000180-howix091	98	23	,	,	,
cord-000180-howix091	98	24	respectively	respectively	RB
cord-000180-howix091	98	25	[	[	-LRB-
cord-000180-howix091	98	26	25	25	CD
cord-000180-howix091	98	27	]	]	-RRB-
cord-000180-howix091	98	28	[	[	-LRB-
cord-000180-howix091	98	29	26	26	CD
cord-000180-howix091	98	30	]	]	-RRB-
cord-000180-howix091	98	31	.	.	.
cord-000180-howix091	99	1	Sodium	sodium	NN
cord-000180-howix091	99	2	dodecyl	dodecyl	NNP
cord-000180-howix091	99	3	sulfate	sulfate	NN
cord-000180-howix091	99	4	-	-	HYPH
cord-000180-howix091	99	5	polyacrylamide	polyacrylamide	NN
cord-000180-howix091	99	6	gel	gel	NN
cord-000180-howix091	99	7	electrophoresis	electrophoresis	NN
cord-000180-howix091	99	8	(	(	-LRB-
cord-000180-howix091	99	9	SDS	SDS	NNP
cord-000180-howix091	99	10	-	-	HYPH
cord-000180-howix091	99	11	PAGE	PAGE	NNP
cord-000180-howix091	99	12	)	)	-RRB-
cord-000180-howix091	99	13	and	and	CC
cord-000180-howix091	99	14	immunoblotting	immunoblotting	NN
cord-000180-howix091	99	15	were	be	VBD
cord-000180-howix091	99	16	performed	perform	VBN
cord-000180-howix091	99	17	as	as	IN
cord-000180-howix091	99	18	described	describe	VBN
cord-000180-howix091	99	19	previously	previously	RB
cord-000180-howix091	99	20	[	[	-LRB-
cord-000180-howix091	99	21	27	27	CD
cord-000180-howix091	99	22	]	]	-RRB-
cord-000180-howix091	99	23	.	.	.
cord-000180-howix091	100	1	Signalling	signal	VBG
cord-000180-howix091	100	2	-	-	HYPH
cord-000180-howix091	100	3	specific	specific	JJ
cord-000180-howix091	100	4	microarrays	microarray	NNS
cord-000180-howix091	100	5	were	be	VBD
cord-000180-howix091	100	6	chosen	choose	VBN
cord-000180-howix091	100	7	as	as	IN
cord-000180-howix091	100	8	an	an	DT
cord-000180-howix091	100	9	initial	initial	JJ
cord-000180-howix091	100	10	route	route	NN
cord-000180-howix091	100	11	to	to	IN
cord-000180-howix091	100	12	identifying	identify	VBG
cord-000180-howix091	100	13	signalling	signal	VBG
cord-000180-howix091	100	14	pathways	pathway	NNS
cord-000180-howix091	100	15	that	that	WDT
cord-000180-howix091	100	16	may	may	MD
cord-000180-howix091	100	17	be	be	VB
cord-000180-howix091	100	18	stimulated	stimulate	VBN
cord-000180-howix091	100	19	early	early	RB
cord-000180-howix091	100	20	in	in	IN
cord-000180-howix091	100	21	HSV-1	hsv-1	NN
cord-000180-howix091	100	22	infection	infection	NN
cord-000180-howix091	100	23	,	,	,
cord-000180-howix091	100	24	and	and	CC
cord-000180-howix091	100	25	more	more	RBR
cord-000180-howix091	100	26	precisely	precisely	RB
cord-000180-howix091	100	27	,	,	,
cord-000180-howix091	100	28	by	by	IN
cord-000180-howix091	100	29	virion	virion	NN
cord-000180-howix091	100	30	binding	binding	NN
cord-000180-howix091	100	31	.	.	.
cord-000180-howix091	101	1	The	the	DT
cord-000180-howix091	101	2	Signal	Signal	NNP
cord-000180-howix091	101	3	Transduction	Transduction	NNP
cord-000180-howix091	101	4	PathwayFinder	PathwayFinder	NNP
cord-000180-howix091	101	5	cDNA	cdna	NN
cord-000180-howix091	101	6	array	array	NN
cord-000180-howix091	101	7	from	from	IN
cord-000180-howix091	101	8	Superarray	Superarray	NNP
cord-000180-howix091	101	9	incorporates	incorporate	VBZ
cord-000180-howix091	101	10	96	96	CD
cord-000180-howix091	101	11	targets	target	NNS
cord-000180-howix091	101	12	covering	cover	VBG
cord-000180-howix091	101	13	19	19	CD
cord-000180-howix091	101	14	associated	associate	VBD
cord-000180-howix091	101	15	signalling	signal	VBG
cord-000180-howix091	101	16	pathways	pathway	NNS
cord-000180-howix091	101	17	,	,	,
cord-000180-howix091	101	18	in	in	IN
cord-000180-howix091	101	19	addition	addition	NN
cord-000180-howix091	101	20	to	to	IN
cord-000180-howix091	101	21	two	two	CD
cord-000180-howix091	101	22	negative	negative	JJ
cord-000180-howix091	101	23	controls	control	NNS
cord-000180-howix091	101	24	corresponding	correspond	VBG
cord-000180-howix091	101	25	to	to	IN
cord-000180-howix091	101	26	pUC18	puc18	NN
cord-000180-howix091	101	27	plasmid	plasmid	NN
cord-000180-howix091	101	28	DNA	DNA	NNP
cord-000180-howix091	101	29	and	and	CC
cord-000180-howix091	101	30	a	a	DT
cord-000180-howix091	101	31	'	'	``
cord-000180-howix091	101	32	blank	blank	JJ
cord-000180-howix091	101	33	'	'	''
cord-000180-howix091	101	34	spot	spot	NN
cord-000180-howix091	101	35	,	,	,
cord-000180-howix091	101	36	as	as	RB
cord-000180-howix091	101	37	well	well	RB
cord-000180-howix091	101	38	as	as	IN
cord-000180-howix091	101	39	four	four	CD
cord-000180-howix091	101	40	positive	positive	JJ
cord-000180-howix091	101	41	controls	control	NNS
cord-000180-howix091	101	42	representing	represent	VBG
cord-000180-howix091	101	43	the	the	DT
cord-000180-howix091	101	44	housekeeping	housekeeping	NN
cord-000180-howix091	101	45	genes	gene	NNS
cord-000180-howix091	101	46	for	for	IN
cord-000180-howix091	101	47	GAPDH	GAPDH	NNP
cord-000180-howix091	101	48	,	,	,
cord-000180-howix091	101	49	beta	beta	NN
cord-000180-howix091	101	50	actin	actin	NN
cord-000180-howix091	101	51	,	,	,
cord-000180-howix091	101	52	cyclophilin	cyclophilin	NNP
cord-000180-howix091	101	53	A	A	NNP
cord-000180-howix091	101	54	and	and	CC
cord-000180-howix091	101	55	ribosomal	ribosomal	JJ
cord-000180-howix091	101	56	protein	protein	NN
cord-000180-howix091	102	1	L13a	l13a	FW
cord-000180-howix091	102	2	.	.	.
cord-000180-howix091	103	1	Serum	serum	NN
cord-000180-howix091	103	2	-	-	HYPH
cord-000180-howix091	103	3	starved	starve	VBN
cord-000180-howix091	103	4	HFFs	hff	NNS
cord-000180-howix091	103	5	were	be	VBD
cord-000180-howix091	103	6	inoculated	inoculate	VBN
cord-000180-howix091	103	7	with	with	IN
cord-000180-howix091	103	8	1000	1000	CD
cord-000180-howix091	103	9	particles	particle	NNS
cord-000180-howix091	103	10	/	/	SYM
cord-000180-howix091	103	11	cell	cell	NN
cord-000180-howix091	103	12	of	of	IN
cord-000180-howix091	103	13	DgB	dgb	NN
cord-000180-howix091	103	14	,	,	,
cord-000180-howix091	103	15	DgD	dgd	NN
cord-000180-howix091	103	16	or	or	CC
cord-000180-howix091	103	17	DgH	dgh	NN
cord-000180-howix091	103	18	entry	entry	NN
cord-000180-howix091	103	19	-	-	HYPH
cord-000180-howix091	103	20	defective	defective	JJ
cord-000180-howix091	103	21	HSV-1	HSV-1	NNP
cord-000180-howix091	103	22	virions	virion	NNS
cord-000180-howix091	103	23	.	.	.
cord-000180-howix091	104	1	Total	Total	NNP
cord-000180-howix091	104	2	RNA	RNA	NNP
cord-000180-howix091	104	3	was	be	VBD
cord-000180-howix091	104	4	isolated	isolate	VBN
cord-000180-howix091	104	5	immediately	immediately	RB
cord-000180-howix091	104	6	after	after	IN
cord-000180-howix091	104	7	inoculation	inoculation	NN
cord-000180-howix091	104	8	,	,	,
cord-000180-howix091	104	9	corresponding	correspond	VBG
cord-000180-howix091	104	10	to	to	IN
cord-000180-howix091	104	11	0	0	CD
cord-000180-howix091	104	12	hpi	hpi	NNP
cord-000180-howix091	104	13	,	,	,
cord-000180-howix091	104	14	and	and	CC
cord-000180-howix091	104	15	6	6	CD
cord-000180-howix091	104	16	hpi	hpi	NNS
cord-000180-howix091	104	17	.	.	.
cord-000180-howix091	105	1	Changes	change	NNS
cord-000180-howix091	105	2	in	in	IN
cord-000180-howix091	105	3	gene	gene	NN
cord-000180-howix091	105	4	expression	expression	NN
cord-000180-howix091	105	5	associated	associate	VBN
cord-000180-howix091	105	6	with	with	IN
cord-000180-howix091	105	7	the	the	DT
cord-000180-howix091	105	8	activation	activation	NN
cord-000180-howix091	105	9	of	of	IN
cord-000180-howix091	105	10	signalling	signal	VBG
cord-000180-howix091	105	11	pathways	pathway	NNS
cord-000180-howix091	105	12	were	be	VBD
cord-000180-howix091	105	13	identified	identify	VBN
cord-000180-howix091	105	14	by	by	IN
cord-000180-howix091	105	15	comparison	comparison	NN
cord-000180-howix091	105	16	to	to	IN
cord-000180-howix091	105	17	the	the	DT
cord-000180-howix091	105	18	transcript	transcript	NN
cord-000180-howix091	105	19	abundance	abundance	NN
cord-000180-howix091	105	20	at	at	IN
cord-000180-howix091	105	21	0	0	CD
cord-000180-howix091	105	22	hpi	hpi	NNP
cord-000180-howix091	105	23	.	.	.
cord-000180-howix091	106	1	The	the	DT
cord-000180-howix091	106	2	results	result	NNS
cord-000180-howix091	106	3	from	from	IN
cord-000180-howix091	106	4	duplicate	duplicate	JJ
cord-000180-howix091	106	5	experiments	experiment	NNS
cord-000180-howix091	106	6	indicated	indicate	VBD
cord-000180-howix091	106	7	that	that	IN
cord-000180-howix091	106	8	downstream	downstream	JJ
cord-000180-howix091	106	9	gene	gene	NN
cord-000180-howix091	106	10	targets	target	NNS
cord-000180-howix091	106	11	of	of	IN
cord-000180-howix091	106	12	a	a	DT
cord-000180-howix091	106	13	number	number	NN
cord-000180-howix091	106	14	of	of	IN
cord-000180-howix091	106	15	signalling	signal	VBG
cord-000180-howix091	106	16	pathways	pathway	NNS
cord-000180-howix091	106	17	are	be	VBP
cord-000180-howix091	106	18	differentially	differentially	RB
cord-000180-howix091	106	19	expressed	express	VBN
cord-000180-howix091	106	20	above	above	IN
cord-000180-howix091	106	21	the	the	DT
cord-000180-howix091	106	22	twofold	twofold	JJ
cord-000180-howix091	106	23	threshold	threshold	NN
cord-000180-howix091	106	24	after	after	IN
cord-000180-howix091	106	25	virion	virion	NN
cord-000180-howix091	106	26	binding	binding	NN
cord-000180-howix091	106	27	(	(	-LRB-
cord-000180-howix091	106	28	Table	table	NN
cord-000180-howix091	106	29	1	1	CD
cord-000180-howix091	106	30	)	)	-RRB-
cord-000180-howix091	106	31	.	.	.
cord-000180-howix091	107	1	These	these	DT
cord-000180-howix091	107	2	preliminary	preliminary	JJ
cord-000180-howix091	107	3	results	result	NNS
cord-000180-howix091	107	4	were	be	VBD
cord-000180-howix091	107	5	then	then	RB
cord-000180-howix091	107	6	used	use	VBN
cord-000180-howix091	107	7	as	as	IN
cord-000180-howix091	107	8	the	the	DT
cord-000180-howix091	107	9	basis	basis	NN
cord-000180-howix091	107	10	of	of	IN
cord-000180-howix091	107	11	quantitative	quantitative	JJ
cord-000180-howix091	107	12	PCR	PCR	NNP
cord-000180-howix091	107	13	studies	study	NNS
cord-000180-howix091	107	14	.	.	.
cord-000180-howix091	108	1	Using	use	VBG
cord-000180-howix091	108	2	the	the	DT
cord-000180-howix091	108	3	same	same	JJ
cord-000180-howix091	108	4	methodology	methodology	NN
cord-000180-howix091	108	5	,	,	,
cord-000180-howix091	108	6	serum	serum	NN
cord-000180-howix091	108	7	-	-	HYPH
cord-000180-howix091	108	8	starved	starve	VBN
cord-000180-howix091	108	9	HFF	HFF	NNP
cord-000180-howix091	108	10	cells	cell	NNS
cord-000180-howix091	108	11	were	be	VBD
cord-000180-howix091	108	12	exposed	expose	VBN
cord-000180-howix091	108	13	to	to	IN
cord-000180-howix091	108	14	1000	1000	CD
cord-000180-howix091	108	15	particles	particle	NNS
cord-000180-howix091	108	16	per	per	IN
cord-000180-howix091	108	17	cell	cell	NN
cord-000180-howix091	108	18	of	of	IN
cord-000180-howix091	108	19	virions	virion	NNS
cord-000180-howix091	108	20	lacking	lack	VBG
cord-000180-howix091	108	21	either	either	CC
cord-000180-howix091	108	22	gD	gD	NNP
cord-000180-howix091	108	23	,	,	,
cord-000180-howix091	108	24	gB	gB	NNP
cord-000180-howix091	108	25	or	or	CC
cord-000180-howix091	108	26	gH	gH	NNP
cord-000180-howix091	108	27	and	and	CC
cord-000180-howix091	108	28	RNA	RNA	NNP
cord-000180-howix091	108	29	was	be	VBD
cord-000180-howix091	108	30	extracted	extract	VBN
cord-000180-howix091	108	31	for	for	IN
cord-000180-howix091	108	32	cDNA	cdna	NN
cord-000180-howix091	108	33	synthesis	synthesis	NN
cord-000180-howix091	108	34	immediately	immediately	RB
cord-000180-howix091	108	35	(	(	-LRB-
cord-000180-howix091	108	36	0	0	NFP
cord-000180-howix091	108	37	h	h	NN
cord-000180-howix091	108	38	)	)	-RRB-
cord-000180-howix091	108	39	or	or	CC
cord-000180-howix091	108	40	after	after	IN
cord-000180-howix091	108	41	6	6	CD
cord-000180-howix091	108	42	h.	h.	NN
cord-000180-howix091	108	43	Table	Table	NNP
cord-000180-howix091	108	44	2	2	CD
cord-000180-howix091	108	45	gives	give	VBZ
cord-000180-howix091	108	46	the	the	DT
cord-000180-howix091	108	47	results	result	NNS
cord-000180-howix091	108	48	of	of	IN
cord-000180-howix091	108	49	three	three	CD
cord-000180-howix091	108	50	independent	independent	JJ
cord-000180-howix091	108	51	experiments	experiment	NNS
cord-000180-howix091	108	52	for	for	IN
cord-000180-howix091	108	53	those	those	DT
cord-000180-howix091	108	54	genes	gene	NNS
cord-000180-howix091	108	55	that	that	WDT
cord-000180-howix091	108	56	were	be	VBD
cord-000180-howix091	108	57	differentially	differentially	RB
cord-000180-howix091	108	58	expressed	express	VBN
cord-000180-howix091	108	59	between	between	IN
cord-000180-howix091	108	60	0	0	CD
cord-000180-howix091	108	61	h	h	NN
cord-000180-howix091	108	62	and	and	CC
cord-000180-howix091	108	63	6	6	CD
cord-000180-howix091	108	64	h	h	NN
cord-000180-howix091	108	65	post	post	NN
cord-000180-howix091	108	66	treatment	treatment	NN
cord-000180-howix091	108	67	and	and	CC
cord-000180-howix091	108	68	is	be	VBZ
cord-000180-howix091	108	69	compared	compare	VBN
cord-000180-howix091	108	70	to	to	IN
cord-000180-howix091	108	71	the	the	DT
cord-000180-howix091	108	72	initial	initial	JJ
cord-000180-howix091	108	73	microarray	microarray	NN
cord-000180-howix091	108	74	results	result	NNS
cord-000180-howix091	108	75	in	in	IN
cord-000180-howix091	108	76	Table	Table	NNP
cord-000180-howix091	108	77	3	3	CD
cord-000180-howix091	108	78	.	.	.
cord-000180-howix091	109	1	It	-PRON-	PRP
cord-000180-howix091	109	2	is	be	VBZ
cord-000180-howix091	109	3	striking	strike	VBG
cord-000180-howix091	109	4	that	that	IN
cord-000180-howix091	109	5	in	in	IN
cord-000180-howix091	109	6	virtually	virtually	RB
cord-000180-howix091	109	7	every	every	DT
cord-000180-howix091	109	8	instance	instance	NN
cord-000180-howix091	109	9	where	where	WRB
cord-000180-howix091	109	10	gene	gene	NN
cord-000180-howix091	109	11	expression	expression	NN
cord-000180-howix091	109	12	is	be	VBZ
cord-000180-howix091	109	13	modified	modify	VBN
cord-000180-howix091	109	14	by	by	IN
cord-000180-howix091	109	15	virion	virion	NN
cord-000180-howix091	109	16	binding	binding	NN
cord-000180-howix091	109	17	,	,	,
cord-000180-howix091	109	18	gD	gD	NNP
cord-000180-howix091	109	19	appears	appear	VBZ
cord-000180-howix091	109	20	to	to	TO
cord-000180-howix091	109	21	be	be	VB
cord-000180-howix091	109	22	the	the	DT
cord-000180-howix091	109	23	key	key	JJ
cord-000180-howix091	109	24	effector	effector	NN
cord-000180-howix091	109	25	.	.	.
cord-000180-howix091	110	1	Virions	virion	NNS
cord-000180-howix091	110	2	lacking	lack	VBG
cord-000180-howix091	110	3	gH	gh	NN
cord-000180-howix091	110	4	or	or	CC
cord-000180-howix091	110	5	gB	gB	NNP
cord-000180-howix091	111	1	had	have	VBD
cord-000180-howix091	111	2	were	be	VBD
cord-000180-howix091	111	3	capable	capable	JJ
cord-000180-howix091	111	4	of	of	IN
cord-000180-howix091	111	5	altering	alter	VBG
cord-000180-howix091	111	6	cellular	cellular	JJ
cord-000180-howix091	111	7	gene	gene	NN
cord-000180-howix091	111	8	expression	expression	NN
cord-000180-howix091	111	9	while	while	IN
cord-000180-howix091	111	10	those	those	DT
cord-000180-howix091	111	11	lacking	lack	VBG
cord-000180-howix091	111	12	gD	gD	NNP
cord-000180-howix091	111	13	had	have	VBD
cord-000180-howix091	111	14	no	no	DT
cord-000180-howix091	111	15	significant	significant	JJ
cord-000180-howix091	111	16	effect	effect	NN
cord-000180-howix091	111	17	.	.	.
cord-000180-howix091	112	1	The	the	DT
cord-000180-howix091	112	2	results	result	NNS
cord-000180-howix091	112	3	can	can	MD
cord-000180-howix091	112	4	be	be	VB
cord-000180-howix091	112	5	summarised	summarise	VBN
cord-000180-howix091	112	6	as	as	IN
cord-000180-howix091	112	7	follows	follow	NNS
cord-000180-howix091	112	8	.	.	.
cord-000180-howix091	113	1	The	the	DT
cord-000180-howix091	113	2	JAK	JAK	NNP
cord-000180-howix091	113	3	/	/	SYM
cord-000180-howix091	113	4	STAT	stat	NN
cord-000180-howix091	113	5	and	and	CC
cord-000180-howix091	113	6	related	relate	VBN
cord-000180-howix091	113	7	JAK	JAK	NNP
cord-000180-howix091	113	8	/	/	SYM
cord-000180-howix091	113	9	Src	Src	NNP
cord-000180-howix091	113	10	pathway	pathway	NN
cord-000180-howix091	113	11	show	show	VBP
cord-000180-howix091	113	12	a	a	DT
cord-000180-howix091	113	13	similar	similar	JJ
cord-000180-howix091	113	14	response	response	NN
cord-000180-howix091	113	15	to	to	IN
cord-000180-howix091	113	16	that	that	DT
cord-000180-howix091	113	17	seen	see	VBN
cord-000180-howix091	113	18	for	for	IN
cord-000180-howix091	113	19	NF	nf	NN
cord-000180-howix091	113	20	-	-	HYPH
cord-000180-howix091	113	21	kB.	kb.	NN
cord-000180-howix091	113	22	Of	of	IN
cord-000180-howix091	113	23	the	the	DT
cord-000180-howix091	113	24	JAK	JAK	NNP
cord-000180-howix091	113	25	/	/	SYM
cord-000180-howix091	113	26	STAT	stat	NN
cord-000180-howix091	113	27	-	-	HYPH
cord-000180-howix091	113	28	responsive	responsive	JJ
cord-000180-howix091	113	29	genes	gene	NNS
cord-000180-howix091	113	30	,	,	,
cord-000180-howix091	113	31	only	only	RB
cord-000180-howix091	113	32	NOS2A	NOS2A	NNP
cord-000180-howix091	113	33	is	be	VBZ
cord-000180-howix091	113	34	regulated	regulate	VBN
cord-000180-howix091	113	35	by	by	IN
cord-000180-howix091	113	36	more	more	JJR
cord-000180-howix091	113	37	than	than	IN
cord-000180-howix091	113	38	one	one	CD
cord-000180-howix091	113	39	pathway	pathway	NN
cord-000180-howix091	113	40	,	,	,
cord-000180-howix091	113	41	with	with	IN
cord-000180-howix091	113	42	DgB	dgb	NN
cord-000180-howix091	113	43	and	and	CC
cord-000180-howix091	113	44	DgH	dgh	NN
cord-000180-howix091	113	45	virions	virion	NNS
cord-000180-howix091	113	46	inducing	induce	VBG
cord-000180-howix091	113	47	their	-PRON-	PRP$
cord-000180-howix091	113	48	transcription	transcription	NN
cord-000180-howix091	113	49	and	and	CC
cord-000180-howix091	113	50	DgD	dgd	NN
cord-000180-howix091	113	51	particles	particle	NNS
cord-000180-howix091	113	52	having	have	VBG
cord-000180-howix091	113	53	no	no	DT
cord-000180-howix091	113	54	significant	significant	JJ
cord-000180-howix091	113	55	effect	effect	NN
cord-000180-howix091	113	56	(	(	-LRB-
cord-000180-howix091	113	57	Table	table	NN
cord-000180-howix091	113	58	2	2	CD
cord-000180-howix091	113	59	)	)	-RRB-
cord-000180-howix091	113	60	.	.	.
cord-000180-howix091	114	1	Although	although	IN
cord-000180-howix091	114	2	the	the	DT
cord-000180-howix091	114	3	JAK/	JAK/	NNP
cord-000180-howix091	114	4	Src	Src	NNP
cord-000180-howix091	114	5	pathway	pathway	NN
cord-000180-howix091	114	6	has	have	VBZ
cord-000180-howix091	114	7	only	only	RB
cord-000180-howix091	114	8	two	two	CD
cord-000180-howix091	114	9	targets	target	NNS
cord-000180-howix091	114	10	on	on	IN
cord-000180-howix091	114	11	the	the	DT
cord-000180-howix091	114	12	signalling	signal	VBG
cord-000180-howix091	114	13	microarraysupon	microarraysupon	NNS
cord-000180-howix091	114	14	which	which	WDT
cord-000180-howix091	114	15	the	the	DT
cord-000180-howix091	114	16	real	real	JJ
cord-000180-howix091	114	17	-	-	HYPH
cord-000180-howix091	114	18	time	time	NN
cord-000180-howix091	114	19	PCR	PCR	NNP
cord-000180-howix091	114	20	experiments	experiment	NNS
cord-000180-howix091	114	21	were	be	VBD
cord-000180-howix091	114	22	based	base	VBN
cord-000180-howix091	114	23	-BCL2L1	-BCL2L1	:
cord-000180-howix091	114	24	is	be	VBZ
cord-000180-howix091	114	25	unique	unique	JJ
cord-000180-howix091	114	26	to	to	IN
cord-000180-howix091	114	27	the	the	DT
cord-000180-howix091	114	28	pathway	pathway	NN
cord-000180-howix091	114	29	,	,	,
cord-000180-howix091	114	30	with	with	IN
cord-000180-howix091	114	31	BCL2	BCL2	NNP
cord-000180-howix091	114	32	expression	expression	NN
cord-000180-howix091	114	33	regulated	regulate	VBN
cord-000180-howix091	114	34	by	by	IN
cord-000180-howix091	114	35	multiple	multiple	JJ
cord-000180-howix091	114	36	signalling	signal	VBG
cord-000180-howix091	114	37	routes	route	NNS
cord-000180-howix091	114	38	.	.	.
cord-000180-howix091	115	1	Interestingly	interestingly	RB
cord-000180-howix091	115	2	,	,	,
cord-000180-howix091	115	3	while	while	IN
cord-000180-howix091	115	4	DgB	dgb	NN
cord-000180-howix091	115	5	and	and	CC
cord-000180-howix091	115	6	DgH	dgh	NN
cord-000180-howix091	115	7	virions	virion	NNS
cord-000180-howix091	115	8	up	up	RB
cord-000180-howix091	115	9	-	-	HYPH
cord-000180-howix091	115	10	regulated	regulate	VBN
cord-000180-howix091	115	11	BCL2	BCL2	NNP
cord-000180-howix091	115	12	and	and	CC
cord-000180-howix091	115	13	BCL2L1	BCL2L1	NNP
cord-000180-howix091	115	14	,	,	,
cord-000180-howix091	115	15	DgD	dgd	JJ
cord-000180-howix091	115	16	virus	virus	NN
cord-000180-howix091	115	17	particles	particle	NNS
cord-000180-howix091	115	18	appeared	appear	VBD
cord-000180-howix091	115	19	to	to	IN
cord-000180-howix091	115	20	down	down	RB
cord-000180-howix091	115	21	-	-	HYPH
cord-000180-howix091	115	22	regulate	regulate	VB
cord-000180-howix091	115	23	both	both	DT
cord-000180-howix091	115	24	targets	target	NNS
cord-000180-howix091	115	25	by	by	IN
cord-000180-howix091	115	26	a	a	DT
cord-000180-howix091	115	27	significant	significant	JJ
cord-000180-howix091	115	28	amount	amount	NN
cord-000180-howix091	115	29	.	.	.
cord-000180-howix091	116	1	Induction	induction	NN
cord-000180-howix091	116	2	of	of	IN
cord-000180-howix091	116	3	this	this	DT
cord-000180-howix091	116	4	pathway	pathway	NN
cord-000180-howix091	116	5	may	may	MD
cord-000180-howix091	116	6	be	be	VB
cord-000180-howix091	116	7	responsible	responsible	JJ
cord-000180-howix091	116	8	for	for	IN
cord-000180-howix091	116	9	the	the	DT
cord-000180-howix091	116	10	upregulation	upregulation	NN
cord-000180-howix091	116	11	of	of	IN
cord-000180-howix091	116	12	CCND1	ccnd1	NN
cord-000180-howix091	116	13	,	,	,
cord-000180-howix091	116	14	MYC	MYC	NNP
cord-000180-howix091	116	15	,	,	,
cord-000180-howix091	116	16	BCL2	BCL2	NNP
cord-000180-howix091	116	17	and	and	CC
cord-000180-howix091	116	18	MMP7	MMP7	NNP
cord-000180-howix091	116	19	after	after	IN
cord-000180-howix091	116	20	inoculation	inoculation	NN
cord-000180-howix091	116	21	with	with	IN
cord-000180-howix091	116	22	DgB	dgb	NN
cord-000180-howix091	116	23	and	and	CC
cord-000180-howix091	116	24	DgH	dgh	NN
cord-000180-howix091	116	25	but	but	CC
cord-000180-howix091	116	26	not	not	RB
cord-000180-howix091	116	27	DgD	dgd	JJ
cord-000180-howix091	116	28	HSV-1	HSV-1	NNP
cord-000180-howix091	116	29	(	(	-LRB-
cord-000180-howix091	116	30	Table	Table	NNP
cord-000180-howix091	116	31	2	2	CD
cord-000180-howix091	116	32	)	)	-RRB-
cord-000180-howix091	116	33	.	.	.
cord-000180-howix091	117	1	Differential	differential	JJ
cord-000180-howix091	117	2	expression	expression	NN
cord-000180-howix091	117	3	of	of	IN
cord-000180-howix091	117	4	CCND1	ccnd1	NN
cord-000180-howix091	118	1	and	and	CC
cord-000180-howix091	118	2	MYC	MYC	NNP
cord-000180-howix091	118	3	can	can	MD
cord-000180-howix091	118	4	be	be	VB
cord-000180-howix091	118	5	regulated	regulate	VBN
cord-000180-howix091	118	6	by	by	IN
cord-000180-howix091	118	7	the	the	DT
cord-000180-howix091	118	8	Wnt	Wnt	NNP
cord-000180-howix091	118	9	and	and	CC
cord-000180-howix091	118	10	PI3	PI3	NNP
cord-000180-howix091	118	11	K	K	NNP
cord-000180-howix091	118	12	signalling	signal	VBG
cord-000180-howix091	118	13	pathways	pathway	NNS
cord-000180-howix091	118	14	,	,	,
cord-000180-howix091	118	15	with	with	IN
cord-000180-howix091	118	16	MYC	MYC	NNP
cord-000180-howix091	118	17	also	also	RB
cord-000180-howix091	118	18	being	be	VBG
cord-000180-howix091	118	19	controlled	control	VBN
cord-000180-howix091	118	20	by	by	IN
cord-000180-howix091	119	1	Protein	Protein	NNP
cord-000180-howix091	119	2	Kinase	Kinase	NNP
cord-000180-howix091	119	3	C.	C.	NNP
cord-000180-howix091	119	4	The	the	DT
cord-000180-howix091	119	5	up	up	JJ
cord-000180-howix091	119	6	-	-	HYPH
cord-000180-howix091	119	7	regulation	regulation	NN
cord-000180-howix091	119	8	of	of	IN
cord-000180-howix091	119	9	MMP7	MMP7	NNP
cord-000180-howix091	119	10	,	,	,
cord-000180-howix091	119	11	which	which	WDT
cord-000180-howix091	119	12	is	be	VBZ
cord-000180-howix091	119	13	the	the	DT
cord-000180-howix091	119	14	only	only	JJ
cord-000180-howix091	119	15	target	target	NN
cord-000180-howix091	119	16	unique	unique	JJ
cord-000180-howix091	119	17	to	to	IN
cord-000180-howix091	119	18	the	the	DT
cord-000180-howix091	119	19	PI3	pi3	NN
cord-000180-howix091	119	20	K	K	NNP
cord-000180-howix091	119	21	pathway	pathway	NN
cord-000180-howix091	119	22	that	that	WDT
cord-000180-howix091	119	23	is	be	VBZ
cord-000180-howix091	119	24	differentially	differentially	RB
cord-000180-howix091	119	25	expressed	express	VBN
cord-000180-howix091	119	26	,	,	,
cord-000180-howix091	119	27	highlights	highlight	VBZ
cord-000180-howix091	119	28	the	the	DT
cord-000180-howix091	119	29	potential	potential	JJ
cord-000180-howix091	119	30	crosstalk	crosstalk	NN
cord-000180-howix091	119	31	between	between	IN
cord-000180-howix091	119	32	signalling	signal	VBG
cord-000180-howix091	119	33	pathways	pathway	NNS
cord-000180-howix091	119	34	and	and	CC
cord-000180-howix091	119	35	can	can	MD
cord-000180-howix091	119	36	not	not	RB
cord-000180-howix091	119	37	exclude	exclude	VB
cord-000180-howix091	119	38	the	the	DT
cord-000180-howix091	119	39	involvement	involvement	NN
cord-000180-howix091	119	40	of	of	IN
cord-000180-howix091	119	41	PI3	pi3	NN
cord-000180-howix091	119	42	kinase	kinase	NN
cord-000180-howix091	119	43	signalling	signal	VBG
cord-000180-howix091	119	44	as	as	IN
cord-000180-howix091	119	45	a	a	DT
cord-000180-howix091	119	46	pathway	pathway	NN
cord-000180-howix091	119	47	leading	lead	VBG
cord-000180-howix091	119	48	to	to	IN
cord-000180-howix091	119	49	transcription	transcription	NN
cord-000180-howix091	119	50	of	of	IN
cord-000180-howix091	119	51	all	all	DT
cord-000180-howix091	119	52	four	four	CD
cord-000180-howix091	119	53	cellular	cellular	JJ
cord-000180-howix091	119	54	genes	gene	NNS
cord-000180-howix091	119	55	.	.	.
cord-000180-howix091	120	1	Both	both	DT
cord-000180-howix091	120	2	DgB	dgb	NN
cord-000180-howix091	120	3	and	and	CC
cord-000180-howix091	120	4	DgH	dgh	NN
cord-000180-howix091	120	5	virions	virion	NNS
cord-000180-howix091	120	6	are	be	VBP
cord-000180-howix091	120	7	capable	capable	JJ
cord-000180-howix091	120	8	of	of	IN
cord-000180-howix091	120	9	stimulating	stimulate	VBG
cord-000180-howix091	120	10	an	an	DT
cord-000180-howix091	120	11	NF	nf	NN
cord-000180-howix091	120	12	-	-	HYPH
cord-000180-howix091	120	13	kB	kb	CD
cord-000180-howix091	120	14	response	response	NN
cord-000180-howix091	120	15	(	(	-LRB-
cord-000180-howix091	120	16	Table	Table	NNP
cord-000180-howix091	120	17	2	2	CD
cord-000180-howix091	120	18	)	)	-RRB-
cord-000180-howix091	120	19	,	,	,
cord-000180-howix091	120	20	a	a	DT
cord-000180-howix091	120	21	result	result	NN
cord-000180-howix091	120	22	that	that	WDT
cord-000180-howix091	120	23	correlates	correlate	VBZ
cord-000180-howix091	120	24	with	with	IN
cord-000180-howix091	120	25	the	the	DT
cord-000180-howix091	120	26	preliminary	preliminary	JJ
cord-000180-howix091	120	27	microarray	microarray	NN
cord-000180-howix091	120	28	data	datum	NNS
cord-000180-howix091	120	29	(	(	-LRB-
cord-000180-howix091	120	30	Table	Table	NNP
cord-000180-howix091	120	31	1	1	CD
cord-000180-howix091	120	32	)	)	-RRB-
cord-000180-howix091	120	33	.	.	.
cord-000180-howix091	121	1	Transcripts	transcript	NNS
cord-000180-howix091	121	2	for	for	IN
cord-000180-howix091	121	3	both	both	CC
cord-000180-howix091	121	4	BIRC-2	BIRC-2	NNP
cord-000180-howix091	121	5	and	and	CC
cord-000180-howix091	121	6	BIRC-3	BIRC-3	NNP
cord-000180-howix091	121	7	are	be	VBP
cord-000180-howix091	121	8	increased	increase	VBN
cord-000180-howix091	121	9	above	above	IN
cord-000180-howix091	121	10	the	the	DT
cord-000180-howix091	121	11	two	two	CD
cord-000180-howix091	121	12	-	-	HYPH
cord-000180-howix091	121	13	fold	fold	JJ
cord-000180-howix091	121	14	threshold	threshold	NN
cord-000180-howix091	121	15	after	after	IN
cord-000180-howix091	121	16	inoculation	inoculation	NN
cord-000180-howix091	121	17	with	with	IN
cord-000180-howix091	121	18	DgB	dgb	NN
cord-000180-howix091	121	19	and	and	CC
cord-000180-howix091	121	20	DgH	dgh	NN
cord-000180-howix091	121	21	HSV-1	hsv-1	NN
cord-000180-howix091	121	22	but	but	CC
cord-000180-howix091	122	1	not	not	RB
cord-000180-howix091	122	2	DgD.	DgD.	NNP
cord-000180-howix091	123	1	There	there	EX
cord-000180-howix091	123	2	appears	appear	VBZ
cord-000180-howix091	123	3	to	to	TO
cord-000180-howix091	123	4	be	be	VB
cord-000180-howix091	123	5	no	no	DT
cord-000180-howix091	123	6	change	change	NN
cord-000180-howix091	123	7	in	in	IN
cord-000180-howix091	123	8	BIRC-1	BIRC-1	NNS
cord-000180-howix091	123	9	expression	expression	NN
cord-000180-howix091	123	10	after	after	IN
cord-000180-howix091	123	11	inoculation	inoculation	NN
cord-000180-howix091	123	12	with	with	IN
cord-000180-howix091	123	13	any	any	DT
cord-000180-howix091	123	14	of	of	IN
cord-000180-howix091	123	15	the	the	DT
cord-000180-howix091	123	16	three	three	CD
cord-000180-howix091	123	17	entry	entry	NN
cord-000180-howix091	123	18	-	-	HYPH
cord-000180-howix091	123	19	defective	defective	JJ
cord-000180-howix091	123	20	mutants	mutant	NNS
cord-000180-howix091	123	21	.	.	.
cord-000180-howix091	124	1	Components	component	NNS
cord-000180-howix091	124	2	of	of	IN
cord-000180-howix091	124	3	the	the	DT
cord-000180-howix091	124	4	NF	NF	NNP
cord-000180-howix091	124	5	-	-	HYPH
cord-000180-howix091	124	6	kB	kb	CD
cord-000180-howix091	124	7	transcriptional	transcriptional	NN
cord-000180-howix091	124	8	complex	complex	NN
cord-000180-howix091	124	9	,	,	,
cord-000180-howix091	124	10	NFKB1	nfkb1	NN
cord-000180-howix091	124	11	and	and	CC
cord-000180-howix091	124	12	REL	REL	NNP
cord-000180-howix091	124	13	,	,	,
cord-000180-howix091	124	14	showed	show	VBD
cord-000180-howix091	124	15	similar	similar	JJ
cord-000180-howix091	124	16	levels	level	NNS
cord-000180-howix091	124	17	of	of	IN
cord-000180-howix091	124	18	increased	increase	VBN
cord-000180-howix091	124	19	transcription	transcription	NN
cord-000180-howix091	124	20	after	after	IN
cord-000180-howix091	124	21	binding	bind	VBG
cord-000180-howix091	124	22	by	by	IN
cord-000180-howix091	124	23	DgB	dgb	NN
cord-000180-howix091	124	24	and	and	CC
cord-000180-howix091	124	25	DgH	DgH	NNP
cord-000180-howix091	124	26	virions	virion	NNS
cord-000180-howix091	124	27	,	,	,
cord-000180-howix091	124	28	a	a	DT
cord-000180-howix091	124	29	response	response	NN
cord-000180-howix091	124	30	that	that	WDT
cord-000180-howix091	124	31	was	be	VBD
cord-000180-howix091	124	32	absent	absent	JJ
cord-000180-howix091	124	33	in	in	IN
cord-000180-howix091	124	34	cells	cell	NNS
cord-000180-howix091	124	35	stimulated	stimulate	VBN
cord-000180-howix091	124	36	with	with	IN
cord-000180-howix091	124	37	gDdeficient	gDdeficient	NNP
cord-000180-howix091	124	38	virions	virion	NNS
cord-000180-howix091	124	39	.	.	.
cord-000180-howix091	125	1	Two	two	CD
cord-000180-howix091	125	2	markers	marker	NNS
cord-000180-howix091	125	3	of	of	IN
cord-000180-howix091	125	4	inflammation	inflammation	NN
cord-000180-howix091	125	5	,	,	,
cord-000180-howix091	125	6	CCL2	CCL2	NNP
cord-000180-howix091	125	7	and	and	CC
cord-000180-howix091	125	8	PECAM1	PECAM1	NNP
cord-000180-howix091	125	9	,	,	,
cord-000180-howix091	125	10	also	also	RB
cord-000180-howix091	125	11	showed	show	VBD
cord-000180-howix091	125	12	a	a	DT
cord-000180-howix091	125	13	significant	significant	JJ
cord-000180-howix091	125	14	change	change	NN
cord-000180-howix091	125	15	in	in	IN
cord-000180-howix091	125	16	gene	gene	NN
cord-000180-howix091	125	17	expression	expression	NN
cord-000180-howix091	125	18	at	at	IN
cord-000180-howix091	125	19	6	6	CD
cord-000180-howix091	125	20	hpi	hpi	NN
cord-000180-howix091	125	21	with	with	IN
cord-000180-howix091	125	22	entry	entry	NN
cord-000180-howix091	125	23	-	-	HYPH
cord-000180-howix091	125	24	defective	defective	JJ
cord-000180-howix091	125	25	HSV-1	HSV-1	NNP
cord-000180-howix091	125	26	lacking	lack	VBG
cord-000180-howix091	125	27	gB	gB	NNP
cord-000180-howix091	125	28	or	or	CC
cord-000180-howix091	125	29	gH	gh	NN
cord-000180-howix091	126	1	but	but	CC
cord-000180-howix091	126	2	not	not	RB
cord-000180-howix091	126	3	gD.	gD.	NNS
cord-000180-howix091	127	1	The	the	DT
cord-000180-howix091	127	2	downstream	downstream	JJ
cord-000180-howix091	127	3	signalling	signalling	NN
cord-000180-howix091	127	4	appears	appear	VBZ
cord-000180-howix091	127	5	specific	specific	JJ
cord-000180-howix091	127	6	as	as	IN
cord-000180-howix091	127	7	not	not	RB
cord-000180-howix091	127	8	all	all	DT
cord-000180-howix091	127	9	NF	NF	NNP
cord-000180-howix091	127	10	-	-	HYPH
cord-000180-howix091	127	11	kB	kb	CD
cord-000180-howix091	127	12	targets	target	NNS
cord-000180-howix091	127	13	were	be	VBD
cord-000180-howix091	127	14	up	up	RB
cord-000180-howix091	127	15	-	-	HYPH
cord-000180-howix091	127	16	regulated	regulate	VBN
cord-000180-howix091	127	17	.	.	.
cord-000180-howix091	128	1	The	the	DT
cord-000180-howix091	128	2	NF	NF	NNP
cord-000180-howix091	128	3	-	-	HYPH
cord-000180-howix091	128	4	kB	kB	NNP
cord-000180-howix091	128	5	repressors	repressor	NNS
cord-000180-howix091	128	6	,	,	,
cord-000180-howix091	128	7	NFKBIA	NFKBIA	NNP
cord-000180-howix091	128	8	and	and	CC
cord-000180-howix091	128	9	NFKBIB	NFKBIB	NNP
cord-000180-howix091	128	10	,	,	,
cord-000180-howix091	128	11	were	be	VBD
cord-000180-howix091	128	12	only	only	RB
cord-000180-howix091	128	13	up	up	RB
cord-000180-howix091	128	14	-	-	HYPH
cord-000180-howix091	128	15	regulated	regulate	VBN
cord-000180-howix091	128	16	by	by	IN
cord-000180-howix091	128	17	DgB	DgB	NNP
cord-000180-howix091	128	18	virion	virion	NN
cord-000180-howix091	128	19	binding	bind	VBG
cord-000180-howix091	128	20	(	(	-LRB-
cord-000180-howix091	128	21	Table	Table	NNP
cord-000180-howix091	128	22	2	2	CD
cord-000180-howix091	128	23	)	)	-RRB-
cord-000180-howix091	128	24	.	.	.
cord-000180-howix091	129	1	To	to	TO
cord-000180-howix091	129	2	confirm	confirm	VB
cord-000180-howix091	129	3	that	that	IN
cord-000180-howix091	129	4	virion	virion	NN
cord-000180-howix091	129	5	binding	binding	NN
cord-000180-howix091	129	6	induces	induce	VBZ
cord-000180-howix091	129	7	NF	NF	NNP
cord-000180-howix091	129	8	-	-	HYPH
cord-000180-howix091	129	9	kB	kB	NNP
cord-000180-howix091	129	10	and	and	CC
cord-000180-howix091	129	11	to	to	TO
cord-000180-howix091	129	12	examine	examine	VB
cord-000180-howix091	129	13	the	the	DT
cord-000180-howix091	129	14	kinetics	kinetic	NNS
cord-000180-howix091	129	15	,	,	,
cord-000180-howix091	129	16	an	an	DT
cord-000180-howix091	129	17	NF	NF	NNP
cord-000180-howix091	129	18	-	-	HYPH
cord-000180-howix091	129	19	kB	kb	CD
cord-000180-howix091	129	20	promoter	promoter	NN
cord-000180-howix091	129	21	-	-	HYPH
cord-000180-howix091	129	22	driven	drive	VBN
cord-000180-howix091	129	23	luciferase	luciferase	NN
cord-000180-howix091	129	24	construct	construct	NN
cord-000180-howix091	129	25	was	be	VBD
cord-000180-howix091	129	26	transfected	transfecte	VBN
cord-000180-howix091	129	27	into	into	IN
cord-000180-howix091	129	28	HFF	HFF	NNP
cord-000180-howix091	129	29	cells	cell	NNS
cord-000180-howix091	129	30	and	and	CC
cord-000180-howix091	129	31	cells	cell	NNS
cord-000180-howix091	129	32	were	be	VBD
cord-000180-howix091	129	33	treated	treat	VBN
cord-000180-howix091	129	34	with	with	IN
cord-000180-howix091	129	35	DgH	dgh	NN
cord-000180-howix091	129	36	virions	virion	NNS
cord-000180-howix091	129	37	(	(	-LRB-
cord-000180-howix091	129	38	1000	1000	CD
cord-000180-howix091	129	39	particles	particle	NNS
cord-000180-howix091	129	40	per	per	IN
cord-000180-howix091	129	41	cell	cell	NN
cord-000180-howix091	129	42	)	)	-RRB-
cord-000180-howix091	129	43	or	or	CC
cord-000180-howix091	129	44	were	be	VBD
cord-000180-howix091	129	45	mock	mock	JJ
cord-000180-howix091	129	46	-	-	HYPH
cord-000180-howix091	129	47	treated	treat	VBN
cord-000180-howix091	129	48	.	.	.
cord-000180-howix091	130	1	Cells	cell	NNS
cord-000180-howix091	130	2	were	be	VBD
cord-000180-howix091	130	3	harvested	harvest	VBN
cord-000180-howix091	130	4	every	every	DT
cord-000180-howix091	130	5	hour	hour	NN
cord-000180-howix091	130	6	until	until	IN
cord-000180-howix091	130	7	9	9	CD
cord-000180-howix091	130	8	hr	hr	NN
cord-000180-howix091	130	9	post	post	NN
cord-000180-howix091	130	10	treatment	treatment	NN
cord-000180-howix091	130	11	,	,	,
cord-000180-howix091	130	12	lysed	lyse	VBN
cord-000180-howix091	130	13	and	and	CC
cord-000180-howix091	130	14	assayed	assay	VBN
cord-000180-howix091	130	15	for	for	IN
cord-000180-howix091	130	16	luciferase	luciferase	JJ
cord-000180-howix091	130	17	activity	activity	NN
cord-000180-howix091	130	18	in	in	IN
cord-000180-howix091	130	19	triplicate	triplicate	NN
cord-000180-howix091	130	20	.	.	.
cord-000180-howix091	131	1	Figure	figure	NN
cord-000180-howix091	131	2	1(a	1(a	CD
cord-000180-howix091	131	3	)	)	-RRB-
cord-000180-howix091	131	4	shows	show	VBZ
cord-000180-howix091	131	5	the	the	DT
cord-000180-howix091	131	6	fold	fold	JJ
cord-000180-howix091	131	7	-	-	HYPH
cord-000180-howix091	131	8	change	change	NN
cord-000180-howix091	131	9	in	in	IN
cord-000180-howix091	131	10	luciferase	luciferase	JJ
cord-000180-howix091	131	11	activity	activity	NN
cord-000180-howix091	131	12	of	of	IN
cord-000180-howix091	131	13	those	those	DT
cord-000180-howix091	131	14	HFFs	hff	NNS
cord-000180-howix091	131	15	inoculated	inoculate	VBN
cord-000180-howix091	131	16	with	with	IN
cord-000180-howix091	131	17	DgH	dgh	NN
cord-000180-howix091	131	18	in	in	IN
cord-000180-howix091	131	19	comparison	comparison	NN
cord-000180-howix091	131	20	to	to	TO
cord-000180-howix091	131	21	mock	mock	VB
cord-000180-howix091	131	22	-	-	HYPH
cord-000180-howix091	131	23	inoculated	inoculate	VBN
cord-000180-howix091	131	24	cells	cell	NNS
cord-000180-howix091	131	25	at	at	IN
cord-000180-howix091	131	26	the	the	DT
cord-000180-howix091	131	27	same	same	JJ
cord-000180-howix091	131	28	time	time	NN
cord-000180-howix091	131	29	point	point	NN
cord-000180-howix091	131	30	.	.	.
cord-000180-howix091	132	1	Biological	biological	JJ
cord-000180-howix091	132	2	duplicates	duplicate	NNS
cord-000180-howix091	132	3	of	of	IN
cord-000180-howix091	132	4	the	the	DT
cord-000180-howix091	132	5	inoculations	inoculation	NNS
cord-000180-howix091	132	6	were	be	VBD
cord-000180-howix091	132	7	performed	perform	VBN
cord-000180-howix091	132	8	with	with	IN
cord-000180-howix091	132	9	the	the	DT
cord-000180-howix091	132	10	lysates	lysate	NNS
cord-000180-howix091	132	11	used	use	VBN
cord-000180-howix091	132	12	in	in	IN
cord-000180-howix091	132	13	triplicate	triplicate	JJ
cord-000180-howix091	132	14	reporter	reporter	NN
cord-000180-howix091	132	15	assays	assay	NNS
cord-000180-howix091	132	16	.	.	.
cord-000180-howix091	133	1	At	at	IN
cord-000180-howix091	133	2	1	1	CD
cord-000180-howix091	133	3	hpi	hpi	NNP
cord-000180-howix091	133	4	,	,	,
cord-000180-howix091	133	5	there	there	EX
cord-000180-howix091	133	6	is	be	VBZ
cord-000180-howix091	133	7	an	an	DT
cord-000180-howix091	133	8	average	average	NN
cord-000180-howix091	133	9	of	of	IN
cord-000180-howix091	133	10	2.4	2.4	CD
cord-000180-howix091	133	11	fold	fold	JJ
cord-000180-howix091	133	12	change	change	NN
cord-000180-howix091	133	13	in	in	IN
cord-000180-howix091	133	14	luciferase	luciferase	JJ
cord-000180-howix091	133	15	activity	activity	NN
cord-000180-howix091	133	16	from	from	IN
cord-000180-howix091	133	17	the	the	DT
cord-000180-howix091	133	18	NF	NF	NNP
cord-000180-howix091	133	19	-	-	HYPH
cord-000180-howix091	133	20	kB	kB	NNP
cord-000180-howix091	133	21	reporter	reporter	NN
cord-000180-howix091	133	22	,	,	,
cord-000180-howix091	133	23	rising	rise	VBG
cord-000180-howix091	133	24	to	to	IN
cord-000180-howix091	133	25	3.5	3.5	CD
cord-000180-howix091	133	26	at	at	IN
cord-000180-howix091	133	27	2	2	CD
cord-000180-howix091	133	28	hpi	hpi	NNP
cord-000180-howix091	133	29	and	and	CC
cord-000180-howix091	133	30	is	be	VBZ
cord-000180-howix091	133	31	maintained	maintain	VBN
cord-000180-howix091	133	32	through	through	IN
cord-000180-howix091	133	33	to	to	IN
cord-000180-howix091	133	34	3	3	CD
cord-000180-howix091	133	35	hpi	hpi	NNP
cord-000180-howix091	133	36	whereby	whereby	WRB
cord-000180-howix091	133	37	it	-PRON-	PRP
cord-000180-howix091	133	38	drops	drop	VBZ
cord-000180-howix091	133	39	to	to	IN
cord-000180-howix091	133	40	1.8	1.8	CD
cord-000180-howix091	133	41	at	at	IN
cord-000180-howix091	133	42	4	4	CD
cord-000180-howix091	133	43	hpi	hpi	NNP
cord-000180-howix091	133	44	,	,	,
cord-000180-howix091	133	45	which	which	WDT
cord-000180-howix091	133	46	correlates	correlate	VBZ
cord-000180-howix091	133	47	with	with	IN
cord-000180-howix091	133	48	the	the	DT
cord-000180-howix091	133	49	half	half	JJ
cord-000180-howix091	133	50	-	-	HYPH
cord-000180-howix091	133	51	life	life	NN
cord-000180-howix091	133	52	of	of	IN
cord-000180-howix091	133	53	luciferase	luciferase	NN
cord-000180-howix091	133	54	[	[	-LRB-
cord-000180-howix091	133	55	28	28	CD
cord-000180-howix091	133	56	]	]	-RRB-
cord-000180-howix091	133	57	.	.	.
cord-000180-howix091	134	1	By	by	IN
cord-000180-howix091	134	2	5	5	CD
cord-000180-howix091	134	3	hpi	hpi	NNP
cord-000180-howix091	134	4	,	,	,
cord-000180-howix091	134	5	and	and	CC
cord-000180-howix091	134	6	until	until	IN
cord-000180-howix091	134	7	9	9	CD
cord-000180-howix091	134	8	hpi	hpi	NNP
cord-000180-howix091	134	9	,	,	,
cord-000180-howix091	134	10	luciferase	luciferase	NN
cord-000180-howix091	134	11	activity	activity	NN
cord-000180-howix091	134	12	drops	drop	NNS
cord-000180-howix091	134	13	to	to	IN
cord-000180-howix091	134	14	baseline	baseline	JJ
cord-000180-howix091	134	15	levels	level	NNS
cord-000180-howix091	134	16	at	at	IN
cord-000180-howix091	134	17	,	,	,
cord-000180-howix091	134	18	or	or	CC
cord-000180-howix091	134	19	near	near	RB
cord-000180-howix091	134	20	,	,	,
cord-000180-howix091	134	21	1-fold	1-fold	CD
cord-000180-howix091	134	22	change	change	NN
cord-000180-howix091	134	23	.	.	.
cord-000180-howix091	135	1	Error	error	NN
cord-000180-howix091	135	2	bars	bar	NNS
cord-000180-howix091	135	3	represent	represent	VBP
cord-000180-howix091	135	4	the	the	DT
cord-000180-howix091	135	5	standard	standard	JJ
cord-000180-howix091	135	6	error	error	NN
cord-000180-howix091	135	7	across	across	IN
cord-000180-howix091	135	8	the	the	DT
cord-000180-howix091	135	9	six	six	CD
cord-000180-howix091	135	10	readings	reading	NNS
cord-000180-howix091	135	11	taken	take	VBN
cord-000180-howix091	135	12	from	from	IN
cord-000180-howix091	135	13	technical	technical	JJ
cord-000180-howix091	135	14	triplicates	triplicate	NNS
cord-000180-howix091	135	15	on	on	IN
cord-000180-howix091	135	16	biological	biological	JJ
cord-000180-howix091	135	17	duplicates	duplicate	NNS
cord-000180-howix091	135	18	.	.	.
cord-000180-howix091	136	1	As	as	IN
cord-000180-howix091	136	2	induction	induction	NN
cord-000180-howix091	136	3	of	of	IN
cord-000180-howix091	136	4	the	the	DT
cord-000180-howix091	136	5	NF	NF	NNP
cord-000180-howix091	136	6	-	-	HYPH
cord-000180-howix091	136	7	kB	kB	NNP
cord-000180-howix091	136	8	reporter	reporter	NN
cord-000180-howix091	136	9	construct	construct	VB
cord-000180-howix091	136	10	occurred	occur	VBN
cord-000180-howix091	136	11	within	within	IN
cord-000180-howix091	136	12	one	one	CD
cord-000180-howix091	136	13	hour	hour	NN
cord-000180-howix091	136	14	of	of	IN
cord-000180-howix091	136	15	inoculation	inoculation	NN
cord-000180-howix091	136	16	with	with	IN
cord-000180-howix091	136	17	DgH	dgh	NN
cord-000180-howix091	136	18	virions	virion	NNS
cord-000180-howix091	136	19	and	and	CC
cord-000180-howix091	136	20	peaked	peak	VBD
cord-000180-howix091	136	21	at	at	IN
cord-000180-howix091	136	22	around	around	RB
cord-000180-howix091	136	23	two	two	CD
cord-000180-howix091	136	24	-	-	HYPH
cord-000180-howix091	136	25	and	and	CC
cord-000180-howix091	136	26	-	-	HYPH
cord-000180-howix091	136	27	a	a	DT
cord-000180-howix091	136	28	-	-	HYPH
cord-000180-howix091	136	29	half	half	NN
cord-000180-howix091	136	30	hours	hour	NNS
cord-000180-howix091	136	31	post	post	NN
cord-000180-howix091	136	32	-	-	NN
cord-000180-howix091	136	33	inoculation	inoculation	NN
cord-000180-howix091	136	34	,	,	,
cord-000180-howix091	136	35	then	then	RB
cord-000180-howix091	136	36	the	the	DT
cord-000180-howix091	136	37	transcripts	transcript	NNS
cord-000180-howix091	136	38	previ-	previ-	XX
cord-000180-howix091	137	1	HFFs	HFFs	NNP
cord-000180-howix091	137	2	were	be	VBD
cord-000180-howix091	137	3	stimulated	stimulate	VBN
cord-000180-howix091	137	4	with	with	IN
cord-000180-howix091	137	5	1000	1000	CD
cord-000180-howix091	137	6	particles	particle	NNS
cord-000180-howix091	137	7	/	/	SYM
cord-000180-howix091	137	8	cell	cell	NN
cord-000180-howix091	137	9	of	of	IN
cord-000180-howix091	137	10	DgB	dgb	NN
cord-000180-howix091	137	11	,	,	,
cord-000180-howix091	137	12	DgD	dgd	NN
cord-000180-howix091	137	13	or	or	CC
cord-000180-howix091	137	14	DgH	dgh	VB
cord-000180-howix091	137	15	HSV-1	hsv-1	NN
cord-000180-howix091	137	16	for	for	IN
cord-000180-howix091	137	17	six	six	CD
cord-000180-howix091	137	18	hours	hour	NNS
cord-000180-howix091	137	19	and	and	CC
cord-000180-howix091	137	20	a	a	DT
cord-000180-howix091	137	21	cDNA	cdna	NN
cord-000180-howix091	137	22	microarray	microarray	NN
cord-000180-howix091	137	23	corresponding	correspond	VBG
cord-000180-howix091	137	24	to	to	IN
cord-000180-howix091	137	25	targets	target	NNS
cord-000180-howix091	137	26	of	of	IN
cord-000180-howix091	137	27	19	19	CD
cord-000180-howix091	137	28	signalling	signal	VBG
cord-000180-howix091	137	29	pathways	pathway	NNS
cord-000180-howix091	137	30	was	be	VBD
cord-000180-howix091	137	31	used	use	VBN
cord-000180-howix091	137	32	to	to	TO
cord-000180-howix091	137	33	detect	detect	VB
cord-000180-howix091	137	34	changes	change	NNS
cord-000180-howix091	137	35	in	in	IN
cord-000180-howix091	137	36	cellular	cellular	JJ
cord-000180-howix091	137	37	gene	gene	NN
cord-000180-howix091	137	38	expression	expression	NN
cord-000180-howix091	137	39	when	when	WRB
cord-000180-howix091	137	40	compared	compare	VBN
cord-000180-howix091	137	41	to	to	IN
cord-000180-howix091	137	42	mock	mock	VB
cord-000180-howix091	137	43	-	-	HYPH
cord-000180-howix091	137	44	infected	infected	JJ
cord-000180-howix091	137	45	.	.	.
cord-000180-howix091	138	1	Infections	infection	NNS
cord-000180-howix091	138	2	and	and	CC
cord-000180-howix091	138	3	mock	mock	JJ
cord-000180-howix091	138	4	infections	infection	NNS
cord-000180-howix091	138	5	were	be	VBD
cord-000180-howix091	138	6	carried	carry	VBN
cord-000180-howix091	138	7	out	out	RP
cord-000180-howix091	138	8	in	in	IN
cord-000180-howix091	138	9	duplicate	duplicate	NN
cord-000180-howix091	138	10	.	.	.
cord-000180-howix091	139	1	A	a	DT
cord-000180-howix091	139	2	number	number	NN
cord-000180-howix091	139	3	of	of	IN
cord-000180-howix091	139	4	signalling	signal	VBG
cord-000180-howix091	139	5	pathways	pathway	NNS
cord-000180-howix091	139	6	were	be	VBD
cord-000180-howix091	139	7	shown	show	VBN
cord-000180-howix091	139	8	to	to	TO
cord-000180-howix091	139	9	be	be	VB
cord-000180-howix091	139	10	stimulated	stimulate	VBN
cord-000180-howix091	139	11	by	by	IN
cord-000180-howix091	139	12	one	one	CD
cord-000180-howix091	139	13	or	or	CC
cord-000180-howix091	139	14	more	more	JJR
cord-000180-howix091	139	15	of	of	IN
cord-000180-howix091	139	16	the	the	DT
cord-000180-howix091	139	17	entry	entry	NN
cord-000180-howix091	139	18	-	-	HYPH
cord-000180-howix091	139	19	defective	defective	JJ
cord-000180-howix091	139	20	mutants	mutant	NNS
cord-000180-howix091	139	21	.	.	.
cord-000180-howix091	140	1	These	these	DT
cord-000180-howix091	140	2	data	datum	NNS
cord-000180-howix091	140	3	were	be	VBD
cord-000180-howix091	140	4	used	use	VBN
cord-000180-howix091	140	5	to	to	TO
cord-000180-howix091	140	6	independently	independently	RB
cord-000180-howix091	140	7	verify	verify	VB
cord-000180-howix091	140	8	changes	change	NNS
cord-000180-howix091	140	9	in	in	IN
cord-000180-howix091	140	10	expression	expression	NN
cord-000180-howix091	140	11	using	use	VBG
cord-000180-howix091	140	12	real	real	JJ
cord-000180-howix091	140	13	-	-	HYPH
cord-000180-howix091	140	14	time	time	NN
cord-000180-howix091	140	15	PCR	PCR	NNP
cord-000180-howix091	140	16	.	.	.
cord-000180-howix091	141	1	doi:10.1371	doi:10.1371	NNP
cord-000180-howix091	142	1	/	/	NFP
cord-000180-howix091	143	1	journal.pone.0009560.t001	journal.pone.0009560.t001	NNP
cord-000180-howix091	144	1	ously	ously	RB
cord-000180-howix091	144	2	shown	show	VBN
cord-000180-howix091	144	3	in	in	IN
cord-000180-howix091	144	4	Table	Table	NNP
cord-000180-howix091	144	5	2	2	CD
cord-000180-howix091	144	6	to	to	TO
cord-000180-howix091	144	7	be	be	VB
cord-000180-howix091	144	8	up	up	RB
cord-000180-howix091	144	9	-	-	HYPH
cord-000180-howix091	144	10	regulated	regulate	VBN
cord-000180-howix091	144	11	as	as	IN
cord-000180-howix091	144	12	a	a	DT
cord-000180-howix091	144	13	result	result	NN
cord-000180-howix091	144	14	of	of	IN
cord-000180-howix091	144	15	DgH	dgh	NN
cord-000180-howix091	144	16	virions	virion	NNS
cord-000180-howix091	144	17	binding	bind	VBG
cord-000180-howix091	144	18	were	be	VBD
cord-000180-howix091	144	19	examined	examine	VBN
cord-000180-howix091	144	20	for	for	IN
cord-000180-howix091	144	21	changes	change	NNS
cord-000180-howix091	144	22	in	in	IN
cord-000180-howix091	144	23	transcript	transcript	NN
cord-000180-howix091	144	24	levels	level	NNS
cord-000180-howix091	144	25	at	at	IN
cord-000180-howix091	144	26	two	two	CD
cord-000180-howix091	144	27	-	-	HYPH
cord-000180-howix091	144	28	and	and	CC
cord-000180-howix091	144	29	-	-	HYPH
cord-000180-howix091	144	30	a	a	DT
cord-000180-howix091	144	31	-	-	HYPH
cord-000180-howix091	144	32	half	half	NN
cord-000180-howix091	144	33	hours	hour	NNS
cord-000180-howix091	144	34	after	after	IN
cord-000180-howix091	144	35	inoculation	inoculation	NN
cord-000180-howix091	144	36	with	with	IN
cord-000180-howix091	144	37	DgH.	dgh.	NN
cord-000180-howix091	145	1	Figure	figure	NN
cord-000180-howix091	145	2	1	1	CD
cord-000180-howix091	145	3	(	(	-LRB-
cord-000180-howix091	145	4	b	b	NN
cord-000180-howix091	145	5	)	)	-RRB-
cord-000180-howix091	145	6	compares	compare	VBZ
cord-000180-howix091	145	7	expression	expression	NN
cord-000180-howix091	145	8	levels	level	NNS
cord-000180-howix091	145	9	at	at	IN
cord-000180-howix091	145	10	two	two	CD
cord-000180-howix091	145	11	-	-	HYPH
cord-000180-howix091	145	12	and	and	CC
cord-000180-howix091	145	13	-	-	HYPH
cord-000180-howix091	145	14	a	a	DT
cord-000180-howix091	145	15	-	-	HYPH
cord-000180-howix091	145	16	half	half	NN
cord-000180-howix091	145	17	and	and	CC
cord-000180-howix091	145	18	six	six	CD
cord-000180-howix091	145	19	hours	hour	NNS
cord-000180-howix091	145	20	postinoculation	postinoculation	NN
cord-000180-howix091	145	21	.	.	.
cord-000180-howix091	146	1	Transcripts	transcript	NNS
cord-000180-howix091	146	2	for	for	IN
cord-000180-howix091	146	3	the	the	DT
cord-000180-howix091	146	4	NF	NF	NNP
cord-000180-howix091	146	5	-	-	HYPH
cord-000180-howix091	146	6	kB	kB	NNP
cord-000180-howix091	146	7	-	-	HYPH
cord-000180-howix091	146	8	responsive	responsive	JJ
cord-000180-howix091	146	9	chemokine	chemokine	NN
cord-000180-howix091	146	10	CCL2	CCL2	NNP
cord-000180-howix091	146	11	were	be	VBD
cord-000180-howix091	146	12	up	up	RB
cord-000180-howix091	146	13	-	-	HYPH
cord-000180-howix091	146	14	regulated	regulate	VBN
cord-000180-howix091	146	15	to	to	IN
cord-000180-howix091	146	16	a	a	DT
cord-000180-howix091	146	17	greater	great	JJR
cord-000180-howix091	146	18	degree	degree	NN
cord-000180-howix091	146	19	at	at	IN
cord-000180-howix091	146	20	two	two	CD
cord-000180-howix091	146	21	-	-	HYPH
cord-000180-howix091	146	22	and	and	CC
cord-000180-howix091	146	23	-	-	HYPH
cord-000180-howix091	146	24	a	a	DT
cord-000180-howix091	146	25	-	-	HYPH
cord-000180-howix091	146	26	half	half	NN
cord-000180-howix091	146	27	hours	hour	NNS
cord-000180-howix091	146	28	than	than	IN
cord-000180-howix091	146	29	at	at	IN
cord-000180-howix091	146	30	six	six	CD
cord-000180-howix091	146	31	hours	hour	NNS
cord-000180-howix091	146	32	post	post	NN
cord-000180-howix091	146	33	-	-	NN
cord-000180-howix091	146	34	inoculation	inoculation	NN
cord-000180-howix091	146	35	.	.	.
cord-000180-howix091	147	1	Of	of	IN
cord-000180-howix091	147	2	the	the	DT
cord-000180-howix091	147	3	NF	NF	NNP
cord-000180-howix091	147	4	-	-	HYPH
cord-000180-howix091	147	5	kB	kB	NNP
cord-000180-howix091	147	6	-	-	HYPH
cord-000180-howix091	147	7	responsive	responsive	JJ
cord-000180-howix091	147	8	genes	gene	NNS
cord-000180-howix091	147	9	,	,	,
cord-000180-howix091	147	10	REL	REL	NNP
cord-000180-howix091	147	11	transcription	transcription	NN
cord-000180-howix091	147	12	was	be	VBD
cord-000180-howix091	147	13	induced	induce	VBN
cord-000180-howix091	147	14	to	to	IN
cord-000180-howix091	147	15	a	a	DT
cord-000180-howix091	147	16	higher	high	JJR
cord-000180-howix091	147	17	level	level	NN
cord-000180-howix091	147	18	whereas	whereas	IN
cord-000180-howix091	147	19	PECAM1	PECAM1	NNP
cord-000180-howix091	148	1	transcript	transcript	NN
cord-000180-howix091	148	2	abundance	abundance	NNP
cord-000180-howix091	148	3	was	be	VBD
cord-000180-howix091	148	4	reduced	reduce	VBN
cord-000180-howix091	148	5	in	in	IN
cord-000180-howix091	148	6	comparison	comparison	NN
cord-000180-howix091	148	7	to	to	TO
cord-000180-howix091	148	8	six	six	CD
cord-000180-howix091	148	9	hours	hour	NNS
cord-000180-howix091	148	10	.	.	.
cord-000180-howix091	149	1	Although	although	IN
cord-000180-howix091	149	2	JAK	JAK	NNP
cord-000180-howix091	149	3	/	/	SYM
cord-000180-howix091	149	4	STAT	stat	NN
cord-000180-howix091	149	5	-	-	HYPH
cord-000180-howix091	149	6	responsive	responsive	JJ
cord-000180-howix091	149	7	targets	target	NNS
cord-000180-howix091	149	8	were	be	VBD
cord-000180-howix091	149	9	not	not	RB
cord-000180-howix091	149	10	differentially	differentially	RB
cord-000180-howix091	149	11	expressed	express	VBN
cord-000180-howix091	149	12	by	by	IN
cord-000180-howix091	149	13	two	two	CD
cord-000180-howix091	149	14	-	-	HYPH
cord-000180-howix091	149	15	and	and	CC
cord-000180-howix091	149	16	-	-	HYPH
cord-000180-howix091	149	17	a	a	DT
cord-000180-howix091	149	18	-	-	HYPH
cord-000180-howix091	149	19	half	half	NN
cord-000180-howix091	149	20	hours	hour	NNS
cord-000180-howix091	149	21	,	,	,
cord-000180-howix091	149	22	the	the	DT
cord-000180-howix091	149	23	JAK	JAK	NNP
cord-000180-howix091	149	24	/	/	SYM
cord-000180-howix091	149	25	Src	Src	NNP
cord-000180-howix091	149	26	targets	target	VBZ
cord-000180-howix091	149	27	BCL2	BCL2	NNP
cord-000180-howix091	149	28	and	and	CC
cord-000180-howix091	149	29	BCL2L1	BCL2L1	NNP
cord-000180-howix091	149	30	were	be	VBD
cord-000180-howix091	149	31	up	up	RB
cord-000180-howix091	149	32	-	-	HYPH
cord-000180-howix091	149	33	regulated	regulate	VBN
cord-000180-howix091	149	34	above	above	IN
cord-000180-howix091	149	35	the	the	DT
cord-000180-howix091	149	36	two	two	CD
cord-000180-howix091	149	37	-	-	HYPH
cord-000180-howix091	149	38	fold	fold	VB
cord-000180-howix091	149	39	arbitrary	arbitrary	JJ
cord-000180-howix091	149	40	threshold	threshold	NN
cord-000180-howix091	149	41	to	to	IN
cord-000180-howix091	149	42	similar	similar	JJ
cord-000180-howix091	149	43	transcript	transcript	NN
cord-000180-howix091	149	44	levels	level	NNS
cord-000180-howix091	149	45	that	that	WDT
cord-000180-howix091	149	46	were	be	VBD
cord-000180-howix091	149	47	seen	see	VBN
cord-000180-howix091	149	48	at	at	IN
cord-000180-howix091	149	49	six	six	CD
cord-000180-howix091	149	50	hours	hour	NNS
cord-000180-howix091	149	51	post	post	NN
cord-000180-howix091	149	52	-	-	NN
cord-000180-howix091	149	53	inoculation	inoculation	NN
cord-000180-howix091	149	54	.	.	.
cord-000180-howix091	150	1	The	the	DT
cord-000180-howix091	150	2	initial	initial	JJ
cord-000180-howix091	150	3	microarray	microarray	NN
cord-000180-howix091	150	4	screen	screen	NN
cord-000180-howix091	150	5	was	be	VBD
cord-000180-howix091	150	6	uninformative	uninformative	JJ
cord-000180-howix091	150	7	with	with	IN
cord-000180-howix091	150	8	respect	respect	NN
cord-000180-howix091	150	9	to	to	IN
cord-000180-howix091	150	10	interferon	interferon	NN
cord-000180-howix091	150	11	signalling	signalling	NN
cord-000180-howix091	150	12	,	,	,
cord-000180-howix091	150	13	but	but	CC
cord-000180-howix091	150	14	this	this	DT
cord-000180-howix091	150	15	was	be	VBD
cord-000180-howix091	150	16	of	of	IN
cord-000180-howix091	150	17	interest	interest	NN
cord-000180-howix091	150	18	because	because	IN
cord-000180-howix091	150	19	soluble	soluble	JJ
cord-000180-howix091	150	20	gD	gD	NNP
cord-000180-howix091	150	21	has	have	VBZ
cord-000180-howix091	150	22	been	be	VBN
cord-000180-howix091	150	23	reported	report	VBN
cord-000180-howix091	150	24	to	to	TO
cord-000180-howix091	150	25	induce	induce	VB
cord-000180-howix091	150	26	IFN	IFN	NNP
cord-000180-howix091	150	27	[	[	-LRB-
cord-000180-howix091	150	28	29	29	CD
cord-000180-howix091	150	29	]	]	-RRB-
cord-000180-howix091	150	30	,	,	,
cord-000180-howix091	150	31	while	while	IN
cord-000180-howix091	150	32	,	,	,
cord-000180-howix091	150	33	in	in	IN
cord-000180-howix091	150	34	contrast	contrast	NN
cord-000180-howix091	150	35	,	,	,
cord-000180-howix091	150	36	ISG	ISG	NNP
cord-000180-howix091	150	37	induction	induction	NN
cord-000180-howix091	150	38	is	be	VBZ
cord-000180-howix091	150	39	reported	report	VBN
cord-000180-howix091	150	40	to	to	TO
cord-000180-howix091	150	41	require	require	VB
cord-000180-howix091	150	42	virion	virion	NN
cord-000180-howix091	150	43	entry	entry	NN
cord-000180-howix091	150	44	but	but	CC
cord-000180-howix091	150	45	not	not	RB
cord-000180-howix091	150	46	de	de	FW
cord-000180-howix091	150	47	novo	novo	NNP
cord-000180-howix091	150	48	protein	protein	NN
cord-000180-howix091	150	49	synthesis	synthesis	NN
cord-000180-howix091	150	50	[	[	-LRB-
cord-000180-howix091	150	51	30	30	CD
cord-000180-howix091	150	52	]	]	-RRB-
cord-000180-howix091	150	53	.	.	.
cord-000180-howix091	151	1	Primers	primer	NNS
cord-000180-howix091	151	2	were	be	VBD
cord-000180-howix091	151	3	designed	design	VBN
cord-000180-howix091	151	4	to	to	TO
cord-000180-howix091	151	5	Type	type	NN
cord-000180-howix091	151	6	I	-PRON-	PRP
cord-000180-howix091	151	7	interferons	interferon	NNS
cord-000180-howix091	151	8	,	,	,
cord-000180-howix091	151	9	a	a	DT
cord-000180-howix091	151	10	(	(	-LRB-
cord-000180-howix091	151	11	IFNA1	ifna1	NN
cord-000180-howix091	151	12	)	)	-RRB-
cord-000180-howix091	151	13	and	and	CC
cord-000180-howix091	151	14	H	H	NNP
cord-000180-howix091	151	15	(	(	-LRB-
cord-000180-howix091	151	16	IFNB1	IFNB1	NNP
cord-000180-howix091	151	17	)	)	-RRB-
cord-000180-howix091	151	18	,	,	,
cord-000180-howix091	151	19	and	and	CC
cord-000180-howix091	151	20	the	the	DT
cord-000180-howix091	151	21	newly	newly	RB
cord-000180-howix091	151	22	designated	designate	VBN
cord-000180-howix091	151	23	Type	Type	NNP
cord-000180-howix091	151	24	III	III	NNP
cord-000180-howix091	151	25	interferon	interferon	NN
cord-000180-howix091	151	26	l	l	NN
cord-000180-howix091	151	27	(	(	-LRB-
cord-000180-howix091	151	28	IL29	IL29	NNP
cord-000180-howix091	151	29	)	)	-RRB-
cord-000180-howix091	151	30	.	.	.
cord-000180-howix091	152	1	Human	human	JJ
cord-000180-howix091	152	2	fibroblasts	fibroblast	NNS
cord-000180-howix091	152	3	do	do	VBP
cord-000180-howix091	152	4	not	not	RB
cord-000180-howix091	152	5	produce	produce	VB
cord-000180-howix091	152	6	interferon	interferon	NN
cord-000180-howix091	152	7	gamma	gamma	NN
cord-000180-howix091	152	8	.	.	.
cord-000180-howix091	153	1	Additionally	additionally	RB
cord-000180-howix091	153	2	,	,	,
cord-000180-howix091	153	3	the	the	DT
cord-000180-howix091	153	4	cDNA	cdna	NN
cord-000180-howix091	153	5	preparation	preparation	NN
cord-000180-howix091	153	6	was	be	VBD
cord-000180-howix091	153	7	used	use	VBN
cord-000180-howix091	153	8	to	to	TO
cord-000180-howix091	153	9	identify	identify	VB
cord-000180-howix091	153	10	any	any	DT
cord-000180-howix091	153	11	change	change	NN
cord-000180-howix091	153	12	in	in	IN
cord-000180-howix091	153	13	the	the	DT
cord-000180-howix091	153	14	abundance	abundance	NN
cord-000180-howix091	153	15	of	of	IN
cord-000180-howix091	153	16	ISGs	isg	NNS
cord-000180-howix091	153	17	.	.	.
cord-000180-howix091	154	1	Both	both	DT
cord-000180-howix091	154	2	DgB	dgb	NN
cord-000180-howix091	154	3	and	and	CC
cord-000180-howix091	154	4	DgH	dgh	NN
cord-000180-howix091	154	5	virions	virion	NNS
cord-000180-howix091	154	6	were	be	VBD
cord-000180-howix091	154	7	able	able	JJ
cord-000180-howix091	154	8	to	to	TO
cord-000180-howix091	154	9	stimulate	stimulate	VB
cord-000180-howix091	154	10	the	the	DT
cord-000180-howix091	154	11	up	up	JJ
cord-000180-howix091	154	12	-	-	HYPH
cord-000180-howix091	154	13	regulation	regulation	NN
cord-000180-howix091	154	14	of	of	IN
cord-000180-howix091	154	15	IFN	IFN	NNP
cord-000180-howix091	154	16	-	-	:
cord-000180-howix091	154	17	a	a	DT
cord-000180-howix091	154	18	expression	expression	NN
cord-000180-howix091	154	19	2.81	2.81	CD
cord-000180-howix091	154	20	fold	fold	NN
cord-000180-howix091	154	21	and	and	CC
cord-000180-howix091	154	22	2.34	2.34	CD
cord-000180-howix091	154	23	fold	fold	NN
cord-000180-howix091	154	24	,	,	,
cord-000180-howix091	154	25	respectively	respectively	RB
cord-000180-howix091	154	26	,	,	,
cord-000180-howix091	154	27	with	with	IN
cord-000180-howix091	154	28	a	a	DT
cord-000180-howix091	154	29	high	high	JJ
cord-000180-howix091	154	30	degree	degree	NN
cord-000180-howix091	154	31	of	of	IN
cord-000180-howix091	154	32	statistical	statistical	JJ
cord-000180-howix091	154	33	significance	significance	NN
cord-000180-howix091	154	34	(	(	-LRB-
cord-000180-howix091	154	35	p#0.05	p#0.05	NNP
cord-000180-howix091	154	36	)	)	-RRB-
cord-000180-howix091	155	1	(	(	-LRB-
cord-000180-howix091	155	2	Table	table	NN
cord-000180-howix091	155	3	4	4	CD
cord-000180-howix091	155	4	)	)	-RRB-
cord-000180-howix091	155	5	.	.	.
cord-000180-howix091	156	1	HSV-1	hsv-1	NN
cord-000180-howix091	156	2	particles	particle	NNS
cord-000180-howix091	156	3	lacking	lack	VBG
cord-000180-howix091	157	1	gD	gD	NNP
cord-000180-howix091	157	2	were	be	VBD
cord-000180-howix091	157	3	unable	unable	JJ
cord-000180-howix091	157	4	to	to	TO
cord-000180-howix091	157	5	do	do	VB
cord-000180-howix091	157	6	so	so	RB
cord-000180-howix091	157	7	,	,	,
cord-000180-howix091	157	8	with	with	IN
cord-000180-howix091	157	9	a	a	DT
cord-000180-howix091	157	10	fold	fold	JJ
cord-000180-howix091	157	11	change	change	NN
cord-000180-howix091	157	12	of	of	IN
cord-000180-howix091	157	13	21.11	21.11	CD
cord-000180-howix091	157	14	and	and	CC
cord-000180-howix091	157	15	a	a	DT
cord-000180-howix091	157	16	p	p	NN
cord-000180-howix091	157	17	=	=	SYM
cord-000180-howix091	157	18	0.15	0.15	CD
cord-000180-howix091	158	1	(	(	-LRB-
cord-000180-howix091	158	2	Table	table	NN
cord-000180-howix091	158	3	4	4	CD
cord-000180-howix091	158	4	)	)	-RRB-
cord-000180-howix091	158	5	.	.	.
cord-000180-howix091	159	1	IFN	IFN	NNP
cord-000180-howix091	159	2	-	-	HYPH
cord-000180-howix091	159	3	H	H	NNP
cord-000180-howix091	159	4	transcript	transcript	NN
cord-000180-howix091	159	5	levels	level	NNS
cord-000180-howix091	159	6	were	be	VBD
cord-000180-howix091	159	7	up	up	RB
cord-000180-howix091	159	8	-	-	HYPH
cord-000180-howix091	159	9	regulated	regulate	VBN
cord-000180-howix091	159	10	2.22	2.22	CD
cord-000180-howix091	159	11	fold	fold	NN
cord-000180-howix091	159	12	by	by	IN
cord-000180-howix091	159	13	DgB	dgb	JJ
cord-000180-howix091	159	14	virions	virion	NNS
cord-000180-howix091	159	15	and	and	CC
cord-000180-howix091	159	16	2.06	2.06	CD
cord-000180-howix091	159	17	fold	fold	NN
cord-000180-howix091	159	18	(	(	-LRB-
cord-000180-howix091	159	19	p	p	NN
cord-000180-howix091	159	20	=	=	SYM
cord-000180-howix091	159	21	0.01	0.01	CD
cord-000180-howix091	159	22	)	)	-RRB-
cord-000180-howix091	159	23	by	by	IN
cord-000180-howix091	159	24	DgD	dgd	JJ
cord-000180-howix091	159	25	virions	virion	NNS
cord-000180-howix091	159	26	,	,	,
cord-000180-howix091	159	27	again	again	RB
cord-000180-howix091	159	28	with	with	IN
cord-000180-howix091	159	29	a	a	DT
cord-000180-howix091	159	30	high	high	JJ
cord-000180-howix091	159	31	degree	degree	NN
cord-000180-howix091	159	32	of	of	IN
cord-000180-howix091	159	33	statistical	statistical	JJ
cord-000180-howix091	159	34	significance	significance	NN
cord-000180-howix091	159	35	.	.	.
cord-000180-howix091	160	1	Inoculation	inoculation	NN
cord-000180-howix091	160	2	with	with	IN
cord-000180-howix091	160	3	virus	virus	NN
cord-000180-howix091	160	4	particles	particle	NNS
cord-000180-howix091	160	5	lacking	lack	VBG
cord-000180-howix091	160	6	gH	gh	NN
cord-000180-howix091	160	7	led	lead	VBD
cord-000180-howix091	160	8	to	to	IN
cord-000180-howix091	160	9	a	a	DT
cord-000180-howix091	160	10	21.07	21.07	CD
cord-000180-howix091	160	11	fold	fold	JJ
cord-000180-howix091	160	12	change	change	NN
cord-000180-howix091	160	13	(	(	-LRB-
cord-000180-howix091	160	14	p	p	NN
cord-000180-howix091	160	15	=	=	SYM
cord-000180-howix091	160	16	0.44	0.44	CD
cord-000180-howix091	160	17	)	)	-RRB-
cord-000180-howix091	160	18	in	in	IN
cord-000180-howix091	160	19	IFN	IFN	NNP
cord-000180-howix091	160	20	-	-	HYPH
cord-000180-howix091	160	21	H	H	NNP
cord-000180-howix091	160	22	expression	expression	NN
cord-000180-howix091	160	23	when	when	WRB
cord-000180-howix091	160	24	compared	compare	VBN
cord-000180-howix091	160	25	to	to	IN
cord-000180-howix091	160	26	mock	mock	VB
cord-000180-howix091	160	27	-	-	HYPH
cord-000180-howix091	160	28	infected	infect	VBN
cord-000180-howix091	160	29	cultures	culture	NNS
cord-000180-howix091	160	30	.	.	.
cord-000180-howix091	161	1	All	all	DT
cord-000180-howix091	161	2	three	three	CD
cord-000180-howix091	161	3	entry	entry	NN
cord-000180-howix091	161	4	-	-	HYPH
cord-000180-howix091	161	5	defective	defective	JJ
cord-000180-howix091	161	6	mutants	mutant	NNS
cord-000180-howix091	161	7	were	be	VBD
cord-000180-howix091	161	8	unable	unable	JJ
cord-000180-howix091	161	9	to	to	TO
cord-000180-howix091	161	10	modulate	modulate	VB
cord-000180-howix091	161	11	the	the	DT
cord-000180-howix091	161	12	expression	expression	NN
cord-000180-howix091	161	13	of	of	IN
cord-000180-howix091	161	14	IFN	IFN	NNP
cord-000180-howix091	161	15	-	-	HYPH
cord-000180-howix091	161	16	l	l	NNP
cord-000180-howix091	161	17	above	above	IN
cord-000180-howix091	161	18	the	the	DT
cord-000180-howix091	161	19	arbitrary	arbitrary	JJ
cord-000180-howix091	161	20	two	two	CD
cord-000180-howix091	161	21	-	-	HYPH
cord-000180-howix091	161	22	fold	fold	JJ
cord-000180-howix091	161	23	threshold	threshold	NN
cord-000180-howix091	161	24	.	.	.
cord-000180-howix091	162	1	The	the	DT
cord-000180-howix091	162	2	glycosylation	glycosylation	NN
cord-000180-howix091	162	3	status	status	NN
cord-000180-howix091	162	4	of	of	IN
cord-000180-howix091	162	5	IFN	IFN	NNP
cord-000180-howix091	162	6	-	-	HYPH
cord-000180-howix091	162	7	inducing	induce	VBG
cord-000180-howix091	162	8	viral	viral	JJ
cord-000180-howix091	162	9	glycoproteins	glycoprotein	NNS
cord-000180-howix091	162	10	is	be	VBZ
cord-000180-howix091	162	11	a	a	DT
cord-000180-howix091	162	12	potential	potential	JJ
cord-000180-howix091	162	13	determinant	determinant	NN
cord-000180-howix091	162	14	of	of	IN
cord-000180-howix091	162	15	induction	induction	NN
cord-000180-howix091	162	16	efficacy	efficacy	NN
cord-000180-howix091	162	17	[	[	-LRB-
cord-000180-howix091	162	18	22	22	CD
cord-000180-howix091	162	19	]	]	-RRB-
cord-000180-howix091	162	20	[	[	-LRB-
cord-000180-howix091	162	21	31	31	CD
cord-000180-howix091	162	22	]	]	-RRB-
cord-000180-howix091	162	23	.	.	.
cord-000180-howix091	163	1	HSV-1	HSV-1	NNP
cord-000180-howix091	163	2	gD	gD	NNP
cord-000180-howix091	163	3	has	have	VBZ
cord-000180-howix091	163	4	three	three	CD
cord-000180-howix091	163	5	potential	potential	JJ
cord-000180-howix091	163	6	N	n	CD
cord-000180-howix091	163	7	-	-	HYPH
cord-000180-howix091	163	8	glycosylation	glycosylation	NN
cord-000180-howix091	163	9	sites	site	NNS
cord-000180-howix091	163	10	but	but	CC
cord-000180-howix091	163	11	lacks	lack	VBZ
cord-000180-howix091	163	12	O	o	NN
cord-000180-howix091	163	13	-	-	HYPH
cord-000180-howix091	163	14	linked	link	VBN
cord-000180-howix091	163	15	glycosylation	glycosylation	NN
cord-000180-howix091	163	16	.	.	.
cord-000180-howix091	164	1	DgH	DgH	NNP
cord-000180-howix091	164	2	virions	virion	NNS
cord-000180-howix091	164	3	,	,	,
cord-000180-howix091	164	4	that	that	WDT
cord-000180-howix091	164	5	retain	retain	VBP
cord-000180-howix091	164	6	expression	expression	NN
cord-000180-howix091	164	7	of	of	IN
cord-000180-howix091	164	8	gD	gD	NNP
cord-000180-howix091	164	9	,	,	,
cord-000180-howix091	164	10	were	be	VBD
cord-000180-howix091	164	11	treated	treat	VBN
cord-000180-howix091	164	12	with	with	IN
cord-000180-howix091	164	13	the	the	DT
cord-000180-howix091	164	14	endoglycosidase	endoglycosidase	NN
cord-000180-howix091	164	15	,	,	,
cord-000180-howix091	164	16	PNGase	PNGase	NNP
cord-000180-howix091	164	17	F	F	NNP
cord-000180-howix091	164	18	,	,	,
cord-000180-howix091	164	19	which	which	WDT
cord-000180-howix091	164	20	removes	remove	VBZ
cord-000180-howix091	164	21	Nlinked	Nlinked	NNP
cord-000180-howix091	164	22	sugars	sugar	NNS
cord-000180-howix091	164	23	.	.	.
cord-000180-howix091	165	1	A	a	DT
cord-000180-howix091	165	2	long	long	JJ
cord-000180-howix091	165	3	incubation	incubation	NN
cord-000180-howix091	165	4	was	be	VBD
cord-000180-howix091	165	5	required	require	VBN
cord-000180-howix091	165	6	as	as	IN
cord-000180-howix091	165	7	the	the	DT
cord-000180-howix091	165	8	denaturing	denaturing	JJ
cord-000180-howix091	165	9	buffer	buffer	NN
cord-000180-howix091	165	10	was	be	VBD
cord-000180-howix091	165	11	excluded	exclude	VBN
cord-000180-howix091	165	12	from	from	IN
cord-000180-howix091	165	13	the	the	DT
cord-000180-howix091	165	14	reaction	reaction	NN
cord-000180-howix091	165	15	to	to	TO
cord-000180-howix091	165	16	avoid	avoid	VB
cord-000180-howix091	165	17	conformational	conformational	JJ
cord-000180-howix091	165	18	changes	change	NNS
cord-000180-howix091	165	19	that	that	WDT
cord-000180-howix091	165	20	might	may	MD
cord-000180-howix091	165	21	abrogate	abrogate	VB
cord-000180-howix091	165	22	virion	virion	NN
cord-000180-howix091	165	23	binding	bind	VBG
cord-000180-howix091	165	24	.	.	.
cord-000180-howix091	166	1	As	as	IN
cord-000180-howix091	166	2	previously	previously	RB
cord-000180-howix091	166	3	shown	show	VBN
cord-000180-howix091	166	4	,	,	,
cord-000180-howix091	166	5	wild	wild	JJ
cord-000180-howix091	166	6	-	-	HYPH
cord-000180-howix091	166	7	type	type	NN
cord-000180-howix091	166	8	virions	virion	NNS
cord-000180-howix091	166	9	treated	treat	VBN
cord-000180-howix091	166	10	in	in	IN
cord-000180-howix091	166	11	a	a	DT
cord-000180-howix091	166	12	similar	similar	JJ
cord-000180-howix091	166	13	manner	manner	NN
cord-000180-howix091	166	14	retained	retain	VBN
cord-000180-howix091	166	15	infectivity	infectivity	NN
cord-000180-howix091	166	16	(	(	-LRB-
cord-000180-howix091	166	17	Figure	figure	NN
cord-000180-howix091	166	18	S1	S1	NNP
cord-000180-howix091	166	19	)	)	-RRB-
cord-000180-howix091	166	20	[	[	-LRB-
cord-000180-howix091	166	21	22	22	CD
cord-000180-howix091	166	22	]	]	-RRB-
cord-000180-howix091	166	23	.	.	.
cord-000180-howix091	167	1	HFF	HFF	NNP
cord-000180-howix091	167	2	were	be	VBD
cord-000180-howix091	167	3	inoculated	inoculate	VBN
cord-000180-howix091	167	4	as	as	IN
cord-000180-howix091	167	5	above	above	RB
cord-000180-howix091	167	6	with	with	IN
cord-000180-howix091	167	7	DgH	dgh	NN
cord-000180-howix091	167	8	virions	virion	NNS
cord-000180-howix091	167	9	that	that	WDT
cord-000180-howix091	167	10	had	have	VBD
cord-000180-howix091	167	11	been	be	VBN
cord-000180-howix091	167	12	incubated	incubate	VBN
cord-000180-howix091	167	13	for	for	IN
cord-000180-howix091	167	14	18	18	CD
cord-000180-howix091	167	15	hrs	hrs	NN
cord-000180-howix091	167	16	in	in	IN
cord-000180-howix091	167	17	the	the	DT
cord-000180-howix091	167	18	presence	presence	NN
cord-000180-howix091	167	19	or	or	CC
cord-000180-howix091	167	20	absence	absence	NN
cord-000180-howix091	167	21	of	of	IN
cord-000180-howix091	167	22	PNGase	PNGase	NNP
cord-000180-howix091	167	23	.	.	.
cord-000180-howix091	168	1	Glycosylated	Glycosylated	NNP
cord-000180-howix091	168	2	and	and	CC
cord-000180-howix091	168	3	deglycosylated	deglycosylate	VBN
cord-000180-howix091	168	4	DgH	dgh	NN
cord-000180-howix091	168	5	virions	virion	NNS
cord-000180-howix091	168	6	stimulated	stimulate	VBD
cord-000180-howix091	168	7	a	a	DT
cord-000180-howix091	168	8	2.23	2.23	CD
cord-000180-howix091	168	9	and	and	CC
cord-000180-howix091	168	10	2.28	2.28	CD
cord-000180-howix091	168	11	fold	fold	NN
cord-000180-howix091	168	12	increase	increase	NN
cord-000180-howix091	168	13	in	in	IN
cord-000180-howix091	168	14	IFN	IFN	NNP
cord-000180-howix091	168	15	-	-	:
cord-000180-howix091	168	16	a	a	DT
cord-000180-howix091	168	17	transcription	transcription	NN
cord-000180-howix091	168	18	,	,	,
cord-000180-howix091	168	19	respectively	respectively	RB
cord-000180-howix091	168	20	.	.	.
cord-000180-howix091	169	1	These	these	DT
cord-000180-howix091	169	2	results	result	NNS
cord-000180-howix091	169	3	suggest	suggest	VBP
cord-000180-howix091	169	4	that	that	IN
cord-000180-howix091	169	5	glycosylation	glycosylation	NN
cord-000180-howix091	169	6	has	have	VBZ
cord-000180-howix091	169	7	no	no	DT
cord-000180-howix091	169	8	impact	impact	NN
cord-000180-howix091	169	9	on	on	IN
cord-000180-howix091	169	10	the	the	DT
cord-000180-howix091	169	11	interferogenic	interferogenic	JJ
cord-000180-howix091	169	12	properties	property	NNS
cord-000180-howix091	169	13	of	of	IN
cord-000180-howix091	169	14	DgH	dgh	NN
cord-000180-howix091	169	15	virions	virion	NNS
cord-000180-howix091	169	16	,	,	,
cord-000180-howix091	169	17	unlike	unlike	IN
cord-000180-howix091	169	18	the	the	DT
cord-000180-howix091	169	19	glycoproteins	glycoprotein	NNS
cord-000180-howix091	169	20	of	of	IN
cord-000180-howix091	169	21	MHV	MHV	NNP
cord-000180-howix091	169	22	and	and	CC
cord-000180-howix091	169	23	TGEV	TGEV	NNP
cord-000180-howix091	169	24	,	,	,
cord-000180-howix091	169	25	which	which	WDT
cord-000180-howix091	169	26	appear	appear	VBP
cord-000180-howix091	169	27	to	to	TO
cord-000180-howix091	169	28	stimulate	stimulate	VB
cord-000180-howix091	169	29	Type	type	NN
cord-000180-howix091	169	30	I	-PRON-	PRP
cord-000180-howix091	169	31	IFN	IFN	NNP
cord-000180-howix091	169	32	through	through	IN
cord-000180-howix091	170	1	There	there	EX
cord-000180-howix091	170	2	was	be	VBD
cord-000180-howix091	170	3	a	a	DT
cord-000180-howix091	170	4	degree	degree	NN
cord-000180-howix091	170	5	of	of	IN
cord-000180-howix091	170	6	correlation	correlation	NN
cord-000180-howix091	170	7	between	between	IN
cord-000180-howix091	170	8	the	the	DT
cord-000180-howix091	170	9	change	change	NN
cord-000180-howix091	170	10	in	in	IN
cord-000180-howix091	170	11	expression	expression	NN
cord-000180-howix091	170	12	determined	determine	VBN
cord-000180-howix091	170	13	by	by	IN
cord-000180-howix091	170	14	microarray	microarray	NN
cord-000180-howix091	170	15	studies	study	NNS
cord-000180-howix091	170	16	and	and	CC
cord-000180-howix091	170	17	those	those	DT
cord-000180-howix091	170	18	confirmed	confirm	VBN
cord-000180-howix091	170	19	by	by	IN
cord-000180-howix091	170	20	real	real	JJ
cord-000180-howix091	170	21	-	-	HYPH
cord-000180-howix091	170	22	time	time	NN
cord-000180-howix091	170	23	PCR	PCR	NNP
cord-000180-howix091	170	24	,	,	,
cord-000180-howix091	170	25	particularly	particularly	RB
cord-000180-howix091	170	26	for	for	IN
cord-000180-howix091	170	27	genes	gene	NNS
cord-000180-howix091	170	28	under	under	IN
cord-000180-howix091	170	29	the	the	DT
cord-000180-howix091	170	30	control	control	NN
cord-000180-howix091	170	31	of	of	IN
cord-000180-howix091	170	32	NF	nf	NN
cord-000180-howix091	170	33	-	-	HYPH
cord-000180-howix091	170	34	kB.	kB.	NNP
cord-000180-howix091	170	35	Note	note	NN
cord-000180-howix091	170	36	:	:	:
cord-000180-howix091	170	37	rel	rel	NNP
cord-000180-howix091	170	38	and	and	CC
cord-000180-howix091	170	39	nfkbib	nfkbib	NNP
cord-000180-howix091	170	40	were	be	VBD
cord-000180-howix091	170	41	not	not	RB
cord-000180-howix091	170	42	present	present	JJ
cord-000180-howix091	170	43	on	on	IN
cord-000180-howix091	170	44	the	the	DT
cord-000180-howix091	170	45	original	original	JJ
cord-000180-howix091	170	46	signalling	signalling	NN
cord-000180-howix091	170	47	-	-	HYPH
cord-000180-howix091	170	48	specific	specific	JJ
cord-000180-howix091	170	49	microarray	microarray	NN
cord-000180-howix091	170	50	,	,	,
cord-000180-howix091	170	51	but	but	CC
cord-000180-howix091	170	52	were	be	VBD
cord-000180-howix091	170	53	included	include	VBN
cord-000180-howix091	170	54	in	in	IN
cord-000180-howix091	170	55	the	the	DT
cord-000180-howix091	170	56	real	real	JJ
cord-000180-howix091	170	57	-	-	HYPH
cord-000180-howix091	170	58	time	time	NN
cord-000180-howix091	170	59	analysis	analysis	NN
cord-000180-howix091	170	60	,	,	,
cord-000180-howix091	170	61	as	as	IN
cord-000180-howix091	170	62	they	-PRON-	PRP
cord-000180-howix091	170	63	are	be	VBP
cord-000180-howix091	170	64	known	know	VBN
cord-000180-howix091	170	65	to	to	TO
cord-000180-howix091	170	66	be	be	VB
cord-000180-howix091	170	67	up	up	RB
cord-000180-howix091	170	68	-	-	HYPH
cord-000180-howix091	170	69	regulated	regulate	VBN
cord-000180-howix091	170	70	as	as	IN
cord-000180-howix091	170	71	part	part	NN
cord-000180-howix091	170	72	of	of	IN
cord-000180-howix091	170	73	the	the	DT
cord-000180-howix091	170	74	NF	NF	NNP
cord-000180-howix091	170	75	-	-	HYPH
cord-000180-howix091	170	76	kB	kB	NNP
cord-000180-howix091	170	77	feedback	feedback	NN
cord-000180-howix091	170	78	mechanism	mechanism	NN
cord-000180-howix091	170	79	.	.	.
cord-000180-howix091	171	1	doi:10.1371	doi:10.1371	NNP
cord-000180-howix091	172	1	/journal.pone.0009560.t003	/journal.pone.0009560.t003	NFP
cord-000180-howix091	172	2	a	a	DT
cord-000180-howix091	172	3	lectin	lectin	NN
cord-000180-howix091	172	4	-	-	HYPH
cord-000180-howix091	172	5	like	like	JJ
cord-000180-howix091	172	6	action	action	NN
cord-000180-howix091	173	1	,	,	,
cord-000180-howix091	173	2	HSV-1	HSV-1	NNP
cord-000180-howix091	173	3	gD	gD	NNP
cord-000180-howix091	173	4	may	may	MD
cord-000180-howix091	173	5	trigger	trigger	VB
cord-000180-howix091	173	6	IFN	IFN	NNP
cord-000180-howix091	173	7	up	up	IN
cord-000180-howix091	173	8	-	-	HYPH
cord-000180-howix091	173	9	regulation	regulation	NN
cord-000180-howix091	173	10	through	through	IN
cord-000180-howix091	173	11	a	a	DT
cord-000180-howix091	173	12	different	different	JJ
cord-000180-howix091	173	13	mechanism	mechanism	NN
cord-000180-howix091	173	14	,	,	,
cord-000180-howix091	173	15	possibly	possibly	RB
cord-000180-howix091	173	16	analogous	analogous	JJ
cord-000180-howix091	173	17	to	to	IN
cord-000180-howix091	173	18	that	that	DT
cord-000180-howix091	173	19	used	use	VBN
cord-000180-howix091	173	20	to	to	TO
cord-000180-howix091	173	21	stimulate	stimulate	VB
cord-000180-howix091	173	22	other	other	JJ
cord-000180-howix091	173	23	signalling	signal	VBG
cord-000180-howix091	173	24	pathways	pathway	NNS
cord-000180-howix091	173	25	.	.	.
cord-000180-howix091	174	1	Five	five	CD
cord-000180-howix091	174	2	interferon	interferon	NN
cord-000180-howix091	174	3	-	-	HYPH
cord-000180-howix091	174	4	stimulated	stimulate	VBN
cord-000180-howix091	174	5	genes	gene	NNS
cord-000180-howix091	174	6	were	be	VBD
cord-000180-howix091	174	7	chosen	choose	VBN
cord-000180-howix091	174	8	to	to	TO
cord-000180-howix091	174	9	examine	examine	VB
cord-000180-howix091	174	10	whether	whether	IN
cord-000180-howix091	174	11	they	-PRON-	PRP
cord-000180-howix091	174	12	were	be	VBD
cord-000180-howix091	174	13	differentially	differentially	RB
cord-000180-howix091	174	14	expressed	express	VBN
cord-000180-howix091	174	15	by	by	IN
cord-000180-howix091	174	16	virion	virion	NN
cord-000180-howix091	174	17	binding	binding	NN
cord-000180-howix091	174	18	.	.	.
cord-000180-howix091	175	1	IFN	IFN	NNP
cord-000180-howix091	175	2	-	-	HYPH
cord-000180-howix091	175	3	induced	induce	VBN
cord-000180-howix091	175	4	protein	protein	NN
cord-000180-howix091	175	5	54	54	CD
cord-000180-howix091	176	1	(	(	-LRB-
cord-000180-howix091	176	2	ISG54	ISG54	NNP
cord-000180-howix091	176	3	)	)	-RRB-
cord-000180-howix091	176	4	transcripts	transcript	NNS
cord-000180-howix091	176	5	are	be	VBP
cord-000180-howix091	176	6	routinely	routinely	RB
cord-000180-howix091	176	7	used	use	VBN
cord-000180-howix091	176	8	as	as	IN
cord-000180-howix091	176	9	a	a	DT
cord-000180-howix091	176	10	marker	marker	NN
cord-000180-howix091	176	11	of	of	IN
cord-000180-howix091	176	12	ISG	ISG	NNP
cord-000180-howix091	176	13	induction	induction	NN
cord-000180-howix091	176	14	.	.	.
cord-000180-howix091	177	1	Binding	bind	VBG
cord-000180-howix091	177	2	by	by	IN
cord-000180-howix091	177	3	DgB	dgb	NN
cord-000180-howix091	177	4	,	,	,
cord-000180-howix091	177	5	DgD	dgd	NN
cord-000180-howix091	177	6	or	or	CC
cord-000180-howix091	177	7	DgH	dgh	NN
cord-000180-howix091	177	8	virions	virion	NNS
cord-000180-howix091	177	9	was	be	VBD
cord-000180-howix091	177	10	insufficient	insufficient	JJ
cord-000180-howix091	177	11	to	to	TO
cord-000180-howix091	177	12	cause	cause	VB
cord-000180-howix091	177	13	changes	change	NNS
cord-000180-howix091	177	14	in	in	IN
cord-000180-howix091	177	15	the	the	DT
cord-000180-howix091	177	16	transcript	transcript	NN
cord-000180-howix091	177	17	abundance	abundance	NN
cord-000180-howix091	177	18	of	of	IN
cord-000180-howix091	177	19	interferon	interferon	NN
cord-000180-howix091	177	20	regulatory	regulatory	JJ
cord-000180-howix091	177	21	factor-1	factor-1	NNP
cord-000180-howix091	177	22	,	,	,
cord-000180-howix091	177	23	-3	-3	NNP
cord-000180-howix091	177	24	,	,	,
cord-000180-howix091	177	25	-7	-7	NNP
cord-000180-howix091	177	26	,	,	,
cord-000180-howix091	177	27	-9	-9	NNP
cord-000180-howix091	178	1	or	or	CC
cord-000180-howix091	178	2	ISG54	ISG54	NNP
cord-000180-howix091	178	3	(	(	-LRB-
cord-000180-howix091	178	4	Table	Table	NNP
cord-000180-howix091	178	5	4	4	CD
cord-000180-howix091	178	6	)	)	-RRB-
cord-000180-howix091	178	7	.	.	.
cord-000180-howix091	179	1	To	to	TO
cord-000180-howix091	179	2	ensure	ensure	VB
cord-000180-howix091	179	3	that	that	IN
cord-000180-howix091	179	4	these	these	DT
cord-000180-howix091	179	5	observations	observation	NNS
cord-000180-howix091	179	6	could	could	MD
cord-000180-howix091	179	7	not	not	RB
cord-000180-howix091	179	8	result	result	VB
cord-000180-howix091	179	9	from	from	IN
cord-000180-howix091	179	10	a	a	DT
cord-000180-howix091	179	11	background	background	NN
cord-000180-howix091	179	12	of	of	IN
cord-000180-howix091	179	13	infection	infection	NN
cord-000180-howix091	179	14	by	by	IN
cord-000180-howix091	179	15	competent	competent	JJ
cord-000180-howix091	179	16	virus	virus	NN
cord-000180-howix091	179	17	,	,	,
cord-000180-howix091	179	18	parallel	parallel	JJ
cord-000180-howix091	179	19	cultures	culture	NNS
cord-000180-howix091	179	20	were	be	VBD
cord-000180-howix091	179	21	infected	infect	VBN
cord-000180-howix091	179	22	with	with	IN
cord-000180-howix091	179	23	wild	wild	JJ
cord-000180-howix091	179	24	type	type	NN
cord-000180-howix091	179	25	virus	virus	NN
cord-000180-howix091	179	26	at	at	IN
cord-000180-howix091	179	27	an	an	DT
cord-000180-howix091	179	28	MOI	MOI	NNP
cord-000180-howix091	179	29	of	of	IN
cord-000180-howix091	179	30	0.01	0.01	CD
cord-000180-howix091	179	31	,	,	,
cord-000180-howix091	179	32	a	a	DT
cord-000180-howix091	179	33	level	level	NN
cord-000180-howix091	179	34	of	of	IN
cord-000180-howix091	179	35	infection	infection	NN
cord-000180-howix091	179	36	some	some	DT
cord-000180-howix091	179	37	tenfold	tenfold	RB
cord-000180-howix091	179	38	higher	higher	RBR
cord-000180-howix091	179	39	than	than	IN
cord-000180-howix091	179	40	would	would	MD
cord-000180-howix091	179	41	result	result	VB
cord-000180-howix091	179	42	from	from	IN
cord-000180-howix091	179	43	the	the	DT
cord-000180-howix091	179	44	'	'	``
cord-000180-howix091	179	45	worst	bad	JJS
cord-000180-howix091	179	46	case	case	NN
cord-000180-howix091	179	47	'	'	''
cord-000180-howix091	179	48	scenario	scenario	NN
cord-000180-howix091	179	49	using	use	VBG
cord-000180-howix091	179	50	preparations	preparation	NNS
cord-000180-howix091	179	51	of	of	IN
cord-000180-howix091	179	52	entry	entry	NN
cord-000180-howix091	179	53	defective	defective	JJ
cord-000180-howix091	179	54	virions	virion	NNS
cord-000180-howix091	179	55	(	(	-LRB-
cord-000180-howix091	179	56	see	see	VB
cord-000180-howix091	179	57	Methods	Methods	NNPS
cord-000180-howix091	179	58	)	)	-RRB-
cord-000180-howix091	179	59	.	.	.
cord-000180-howix091	180	1	These	these	DT
cord-000180-howix091	180	2	cultures	culture	NNS
cord-000180-howix091	180	3	exhibited	exhibit	VBD
cord-000180-howix091	180	4	no	no	DT
cord-000180-howix091	180	5	induction	induction	NN
cord-000180-howix091	180	6	of	of	IN
cord-000180-howix091	180	7	IFN	IFN	NNP
cord-000180-howix091	180	8	or	or	CC
cord-000180-howix091	180	9	ISGs	ISGs	NNPS
cord-000180-howix091	180	10	(	(	-LRB-
cord-000180-howix091	180	11	Table	Table	NNP
cord-000180-howix091	180	12	4	4	CD
cord-000180-howix091	180	13	)	)	-RRB-
cord-000180-howix091	180	14	.	.	.
cord-000180-howix091	181	1	All	all	PDT
cord-000180-howix091	181	2	the	the	DT
cord-000180-howix091	181	3	experimental	experimental	JJ
cord-000180-howix091	181	4	work	work	NN
cord-000180-howix091	181	5	described	describe	VBN
cord-000180-howix091	181	6	above	above	RB
cord-000180-howix091	181	7	was	be	VBD
cord-000180-howix091	181	8	performed	perform	VBN
cord-000180-howix091	181	9	using	use	VBG
cord-000180-howix091	181	10	treatments	treatment	NNS
cord-000180-howix091	181	11	with	with	IN
cord-000180-howix091	181	12	1000	1000	CD
cord-000180-howix091	181	13	virus	virus	NN
cord-000180-howix091	181	14	particles	particle	NNS
cord-000180-howix091	181	15	per	per	IN
cord-000180-howix091	181	16	cell	cell	NN
cord-000180-howix091	181	17	,	,	,
cord-000180-howix091	181	18	a	a	DT
cord-000180-howix091	181	19	condition	condition	NN
cord-000180-howix091	181	20	that	that	WDT
cord-000180-howix091	181	21	would	would	MD
cord-000180-howix091	181	22	be	be	VB
cord-000180-howix091	181	23	unlikely	unlikely	JJ
cord-000180-howix091	181	24	to	to	TO
cord-000180-howix091	181	25	pertain	pertain	VB
cord-000180-howix091	181	26	in	in	IN
cord-000180-howix091	181	27	natural	natural	JJ
cord-000180-howix091	181	28	primary	primary	JJ
cord-000180-howix091	181	29	infections	infection	NNS
cord-000180-howix091	181	30	.	.	.
cord-000180-howix091	182	1	To	to	TO
cord-000180-howix091	182	2	establish	establish	VB
cord-000180-howix091	182	3	whether	whether	IN
cord-000180-howix091	182	4	much	much	JJ
cord-000180-howix091	182	5	lower	low	JJR
cord-000180-howix091	182	6	virion	virion	NN
cord-000180-howix091	182	7	numbers	number	NNS
cord-000180-howix091	182	8	would	would	MD
cord-000180-howix091	182	9	be	be	VB
cord-000180-howix091	182	10	effective	effective	JJ
cord-000180-howix091	182	11	,	,	,
cord-000180-howix091	182	12	HFFs	HFFs	NNP
cord-000180-howix091	182	13	were	be	VBD
cord-000180-howix091	182	14	serum	serum	NN
cord-000180-howix091	182	15	-	-	HYPH
cord-000180-howix091	182	16	starved	starve	VBN
cord-000180-howix091	182	17	for	for	IN
cord-000180-howix091	182	18	five	five	CD
cord-000180-howix091	182	19	days	day	NNS
cord-000180-howix091	182	20	then	then	RB
cord-000180-howix091	182	21	mock	mock	VB
cord-000180-howix091	182	22	-	-	HYPH
cord-000180-howix091	182	23	inoculated	inoculate	VBN
cord-000180-howix091	182	24	or	or	CC
cord-000180-howix091	182	25	inoculated	inoculate	VBN
cord-000180-howix091	182	26	with	with	IN
cord-000180-howix091	182	27	1	1	CD
cord-000180-howix091	182	28	,	,	,
cord-000180-howix091	182	29	10	10	CD
cord-000180-howix091	182	30	,	,	,
cord-000180-howix091	182	31	100	100	CD
cord-000180-howix091	182	32	or	or	CC
cord-000180-howix091	182	33	1000	1000	CD
cord-000180-howix091	182	34	particles	particle	NNS
cord-000180-howix091	182	35	per	per	IN
cord-000180-howix091	182	36	cell	cell	NN
cord-000180-howix091	182	37	of	of	IN
cord-000180-howix091	182	38	DgH	dgh	NN
cord-000180-howix091	182	39	HSV-1	HSV-1	NNP
cord-000180-howix091	182	40	for	for	IN
cord-000180-howix091	182	41	six	six	CD
cord-000180-howix091	182	42	hours	hour	NNS
cord-000180-howix091	182	43	.	.	.
cord-000180-howix091	183	1	Infections	infection	NNS
cord-000180-howix091	183	2	were	be	VBD
cord-000180-howix091	183	3	carried	carry	VBN
cord-000180-howix091	183	4	out	out	RP
cord-000180-howix091	183	5	in	in	IN
cord-000180-howix091	183	6	duplicate	duplicate	NN
cord-000180-howix091	183	7	with	with	IN
cord-000180-howix091	183	8	mockinoculated	mockinoculated	JJ
cord-000180-howix091	183	9	controls	control	NNS
cord-000180-howix091	183	10	that	that	WDT
cord-000180-howix091	183	11	received	receive	VBD
cord-000180-howix091	183	12	an	an	DT
cord-000180-howix091	183	13	equivalent	equivalent	JJ
cord-000180-howix091	183	14	volume	volume	NN
cord-000180-howix091	183	15	of	of	IN
cord-000180-howix091	183	16	PBS	PBS	NNP
cord-000180-howix091	183	17	.	.	.
cord-000180-howix091	184	1	Total	Total	NNP
cord-000180-howix091	184	2	RNA	RNA	NNP
cord-000180-howix091	184	3	was	be	VBD
cord-000180-howix091	184	4	purified	purify	VBN
cord-000180-howix091	184	5	and	and	CC
cord-000180-howix091	184	6	reverse	reverse	VB
cord-000180-howix091	184	7	transcribed	transcribe	VBN
cord-000180-howix091	184	8	,	,	,
cord-000180-howix091	184	9	with	with	IN
cord-000180-howix091	184	10	the	the	DT
cord-000180-howix091	184	11	cDNA	cdna	NN
cord-000180-howix091	184	12	from	from	IN
cord-000180-howix091	184	13	each	each	DT
cord-000180-howix091	184	14	duplicate	duplicate	JJ
cord-000180-howix091	184	15	inoculation	inoculation	NN
cord-000180-howix091	184	16	used	use	VBN
cord-000180-howix091	184	17	in	in	IN
cord-000180-howix091	184	18	triplicate	triplicate	NN
cord-000180-howix091	184	19	for	for	IN
cord-000180-howix091	184	20	real	real	JJ
cord-000180-howix091	184	21	-	-	HYPH
cord-000180-howix091	184	22	time	time	NN
cord-000180-howix091	184	23	PCR	PCR	NNP
cord-000180-howix091	184	24	.	.	.
cord-000180-howix091	185	1	The	the	DT
cord-000180-howix091	185	2	NF	NF	NNP
cord-000180-howix091	185	3	-	-	HYPH
cord-000180-howix091	185	4	kB	kB	NNP
cord-000180-howix091	185	5	responsive	responsive	JJ
cord-000180-howix091	185	6	genes	gene	NNS
cord-000180-howix091	186	1	NFKB1	nfkb1	NN
cord-000180-howix091	186	2	,	,	,
cord-000180-howix091	186	3	REL	REL	NNP
cord-000180-howix091	186	4	and	and	CC
cord-000180-howix091	186	5	CCL2	CCL2	NNP
cord-000180-howix091	186	6	,	,	,
cord-000180-howix091	186	7	in	in	IN
cord-000180-howix091	186	8	addition	addition	NN
cord-000180-howix091	186	9	to	to	IN
cord-000180-howix091	186	10	the	the	DT
cord-000180-howix091	186	11	JAK	JAK	NNP
cord-000180-howix091	186	12	/	/	SYM
cord-000180-howix091	186	13	STAT	STAT	NNP
cord-000180-howix091	186	14	target	target	NN
cord-000180-howix091	186	15	NOS2A	NOS2A	NNP
cord-000180-howix091	186	16	,	,	,
cord-000180-howix091	186	17	were	be	VBD
cord-000180-howix091	186	18	used	use	VBN
cord-000180-howix091	186	19	as	as	IN
cord-000180-howix091	186	20	they	-PRON-	PRP
cord-000180-howix091	186	21	had	have	VBD
cord-000180-howix091	186	22	previously	previously	RB
cord-000180-howix091	186	23	been	be	VBN
cord-000180-howix091	186	24	shown	show	VBN
cord-000180-howix091	186	25	to	to	TO
cord-000180-howix091	186	26	be	be	VB
cord-000180-howix091	186	27	differentially	differentially	RB
cord-000180-howix091	186	28	expressed	express	VBN
cord-000180-howix091	186	29	after	after	IN
cord-000180-howix091	186	30	inoculation	inoculation	NN
cord-000180-howix091	186	31	with	with	IN
cord-000180-howix091	186	32	1000	1000	CD
cord-000180-howix091	186	33	particles	particle	NNS
cord-000180-howix091	186	34	/	/	SYM
cord-000180-howix091	186	35	cell	cell	NN
cord-000180-howix091	186	36	of	of	IN
cord-000180-howix091	186	37	DgH	dgh	NN
cord-000180-howix091	186	38	HSV-1	HSV-1	NNP
cord-000180-howix091	186	39	.	.	.
cord-000180-howix091	187	1	Recalling	recall	VBG
cord-000180-howix091	187	2	that	that	IN
cord-000180-howix091	187	3	the	the	DT
cord-000180-howix091	187	4	more	more	RBR
cord-000180-howix091	187	5	abundant	abundant	JJ
cord-000180-howix091	187	6	a	a	DT
cord-000180-howix091	187	7	transcript	transcript	NN
cord-000180-howix091	188	1	the	the	DT
cord-000180-howix091	188	2	fewer	few	JJR
cord-000180-howix091	188	3	number	number	NN
cord-000180-howix091	188	4	of	of	IN
cord-000180-howix091	188	5	cycles	cycle	NNS
cord-000180-howix091	188	6	it	-PRON-	PRP
cord-000180-howix091	188	7	takes	take	VBZ
cord-000180-howix091	188	8	to	to	TO
cord-000180-howix091	188	9	cross	cross	VB
cord-000180-howix091	188	10	a	a	DT
cord-000180-howix091	188	11	threshold	threshold	NN
cord-000180-howix091	188	12	set	set	VBN
cord-000180-howix091	188	13	in	in	IN
cord-000180-howix091	188	14	the	the	DT
cord-000180-howix091	188	15	exponential	exponential	JJ
cord-000180-howix091	188	16	phase	phase	NN
cord-000180-howix091	188	17	of	of	IN
cord-000180-howix091	188	18	PCR	PCR	NNP
cord-000180-howix091	188	19	product	product	NN
cord-000180-howix091	188	20	accumulation	accumulation	NN
cord-000180-howix091	188	21	(	(	-LRB-
cord-000180-howix091	188	22	the	the	DT
cord-000180-howix091	188	23	C	C	NNP
cord-000180-howix091	188	24	T	T	NNP
cord-000180-howix091	188	25	value	value	NN
cord-000180-howix091	188	26	)	)	-RRB-
cord-000180-howix091	188	27	,	,	,
cord-000180-howix091	188	28	Figure	figure	NN
cord-000180-howix091	188	29	2	2	CD
cord-000180-howix091	188	30	plots	plot	NNS
cord-000180-howix091	188	31	the	the	DT
cord-000180-howix091	188	32	DC	DC	NNP
cord-000180-howix091	188	33	T	T	NNP
cord-000180-howix091	188	34	value	value	NN
cord-000180-howix091	188	35	on	on	IN
cord-000180-howix091	188	36	the	the	DT
cord-000180-howix091	188	37	y	y	NN
cord-000180-howix091	188	38	-	-	HYPH
cord-000180-howix091	188	39	axis	axis	NN
cord-000180-howix091	188	40	,	,	,
cord-000180-howix091	188	41	(	(	-LRB-
cord-000180-howix091	188	42	i.e.	i.e.	FW
cord-000180-howix091	188	43	the	the	DT
cord-000180-howix091	188	44	C	C	NNP
cord-000180-howix091	188	45	T	T	NNP
cord-000180-howix091	188	46	value	value	NN
cord-000180-howix091	188	47	for	for	IN
cord-000180-howix091	188	48	the	the	DT
cord-000180-howix091	188	49	gene	gene	NN
cord-000180-howix091	188	50	of	of	IN
cord-000180-howix091	188	51	interest	interest	NN
cord-000180-howix091	188	52	after	after	IN
cord-000180-howix091	188	53	normalisation	normalisation	NN
cord-000180-howix091	188	54	against	against	IN
cord-000180-howix091	188	55	the	the	DT
cord-000180-howix091	188	56	RPL13	RPL13	NNP
cord-000180-howix091	188	57	)	)	-RRB-
cord-000180-howix091	188	58	against	against	IN
cord-000180-howix091	188	59	the	the	DT
cord-000180-howix091	188	60	multiplicity	multiplicity	NN
cord-000180-howix091	188	61	of	of	IN
cord-000180-howix091	188	62	infection	infection	NN
cord-000180-howix091	188	63	on	on	IN
cord-000180-howix091	188	64	the	the	DT
cord-000180-howix091	188	65	x	x	NN
cord-000180-howix091	188	66	-	-	HYPH
cord-000180-howix091	188	67	axis	axis	NN
cord-000180-howix091	188	68	.	.	.
cord-000180-howix091	189	1	As	as	IN
cord-000180-howix091	189	2	the	the	DT
cord-000180-howix091	189	3	multiplicity	multiplicity	NN
cord-000180-howix091	189	4	of	of	IN
cord-000180-howix091	189	5	DgH	dgh	NN
cord-000180-howix091	189	6	increases	increase	VBZ
cord-000180-howix091	189	7	the	the	DT
cord-000180-howix091	189	8	C	C	NNP
cord-000180-howix091	189	9	T	T	NNP
cord-000180-howix091	189	10	value	value	NN
cord-000180-howix091	189	11	decreases	decrease	NNS
cord-000180-howix091	189	12	,	,	,
cord-000180-howix091	189	13	indicating	indicate	VBG
cord-000180-howix091	189	14	an	an	DT
cord-000180-howix091	189	15	increase	increase	NN
cord-000180-howix091	189	16	in	in	IN
cord-000180-howix091	189	17	the	the	DT
cord-000180-howix091	189	18	abundance	abundance	NN
cord-000180-howix091	189	19	of	of	IN
cord-000180-howix091	189	20	transcripts	transcript	NNS
cord-000180-howix091	189	21	for	for	IN
cord-000180-howix091	189	22	all	all	DT
cord-000180-howix091	189	23	three	three	CD
cord-000180-howix091	189	24	NF	nf	NN
cord-000180-howix091	189	25	-	-	HYPH
cord-000180-howix091	189	26	kB	kB	NNP
cord-000180-howix091	189	27	targets	target	NNS
cord-000180-howix091	189	28	(	(	-LRB-
cord-000180-howix091	189	29	Figure	figure	NN
cord-000180-howix091	189	30	2(a	2(a	CD
cord-000180-howix091	189	31	)	)	-RRB-
cord-000180-howix091	189	32	)	)	-RRB-
cord-000180-howix091	189	33	.	.	.
cord-000180-howix091	190	1	A	a	DT
cord-000180-howix091	190	2	logarithmic	logarithmic	JJ
cord-000180-howix091	190	3	regression	regression	NN
cord-000180-howix091	190	4	analysis	analysis	NN
cord-000180-howix091	190	5	across	across	IN
cord-000180-howix091	190	6	three	three	CD
cord-000180-howix091	190	7	logs	log	NNS
cord-000180-howix091	190	8	of	of	IN
cord-000180-howix091	190	9	multiplicity	multiplicity	NN
cord-000180-howix091	190	10	show	show	VBP
cord-000180-howix091	190	11	a	a	DT
cord-000180-howix091	190	12	high	high	JJ
cord-000180-howix091	190	13	correlation	correlation	NN
cord-000180-howix091	190	14	between	between	IN
cord-000180-howix091	190	15	the	the	DT
cord-000180-howix091	190	16	four	four	CD
cord-000180-howix091	190	17	C	c	NN
cord-000180-howix091	190	18	T	t	NN
cord-000180-howix091	190	19	values	value	NNS
cord-000180-howix091	190	20	for	for	IN
cord-000180-howix091	190	21	each	each	DT
cord-000180-howix091	190	22	transcript	transcript	NN
cord-000180-howix091	190	23	with	with	IN
cord-000180-howix091	190	24	r	r	NNP
cord-000180-howix091	190	25	2	2	CD
cord-000180-howix091	190	26	.0.98	.0.98	.
cord-000180-howix091	190	27	.	.	.
cord-000180-howix091	191	1	Similarly	similarly	RB
cord-000180-howix091	191	2	for	for	IN
cord-000180-howix091	191	3	the	the	DT
cord-000180-howix091	191	4	JAK	JAK	NNP
cord-000180-howix091	191	5	/	/	SYM
cord-000180-howix091	191	6	STAT	STAT	NNP
cord-000180-howix091	191	7	responsive	responsive	JJ
cord-000180-howix091	191	8	target	target	NN
cord-000180-howix091	191	9	NOS2A	NOS2A	JJS
cord-000180-howix091	191	10	there	there	EX
cord-000180-howix091	191	11	are	be	VBP
cord-000180-howix091	191	12	almost	almost	RB
cord-000180-howix091	191	13	two	two	CD
cord-000180-howix091	191	14	cycles	cycle	NNS
cord-000180-howix091	191	15	of	of	IN
cord-000180-howix091	191	16	a	a	DT
cord-000180-howix091	191	17	difference	difference	NN
cord-000180-howix091	191	18	between	between	IN
cord-000180-howix091	191	19	the	the	DT
cord-000180-howix091	191	20	level	level	NN
cord-000180-howix091	191	21	of	of	IN
cord-000180-howix091	191	22	transcripts	transcript	NNS
cord-000180-howix091	191	23	after	after	IN
cord-000180-howix091	191	24	infection	infection	NN
cord-000180-howix091	191	25	with	with	IN
cord-000180-howix091	191	26	1	1	CD
cord-000180-howix091	191	27	particle	particle	NN
cord-000180-howix091	191	28	/	/	SYM
cord-000180-howix091	191	29	cell	cell	NN
cord-000180-howix091	191	30	compared	compare	VBN
cord-000180-howix091	191	31	to	to	IN
cord-000180-howix091	191	32	1000	1000	CD
cord-000180-howix091	191	33	particles	particle	NNS
cord-000180-howix091	191	34	/	/	SYM
cord-000180-howix091	191	35	cell	cell	NN
cord-000180-howix091	191	36	(	(	-LRB-
cord-000180-howix091	191	37	Figure	figure	NN
cord-000180-howix091	191	38	2(b	2(b	CD
cord-000180-howix091	191	39	)	)	-RRB-
cord-000180-howix091	191	40	)	)	-RRB-
cord-000180-howix091	191	41	.	.	.
cord-000180-howix091	192	1	This	this	DT
cord-000180-howix091	192	2	larger	large	JJR
cord-000180-howix091	192	3	response	response	NN
cord-000180-howix091	192	4	than	than	IN
cord-000180-howix091	192	5	those	those	DT
cord-000180-howix091	192	6	for	for	IN
cord-000180-howix091	192	7	NF	NF	NNP
cord-000180-howix091	192	8	-	-	HYPH
cord-000180-howix091	192	9	kB	kB	NNP
cord-000180-howix091	192	10	responsive	responsive	JJ
cord-000180-howix091	192	11	genes	gene	NNS
cord-000180-howix091	192	12	is	be	VBZ
cord-000180-howix091	192	13	indicative	indicative	JJ
cord-000180-howix091	192	14	of	of	IN
cord-000180-howix091	192	15	the	the	DT
cord-000180-howix091	192	16	different	different	JJ
cord-000180-howix091	192	17	level	level	NN
cord-000180-howix091	192	18	of	of	IN
cord-000180-howix091	192	19	induction	induction	NN
cord-000180-howix091	192	20	shown	show	VBN
cord-000180-howix091	192	21	with	with	IN
cord-000180-howix091	192	22	previous	previous	JJ
cord-000180-howix091	192	23	real	real	JJ
cord-000180-howix091	192	24	-	-	HYPH
cord-000180-howix091	192	25	time	time	NN
cord-000180-howix091	192	26	PCR	PCR	NNP
cord-000180-howix091	192	27	analysis	analysis	NN
cord-000180-howix091	192	28	of	of	IN
cord-000180-howix091	192	29	these	these	DT
cord-000180-howix091	192	30	transcripts	transcript	NNS
cord-000180-howix091	192	31	(	(	-LRB-
cord-000180-howix091	192	32	Table	table	NN
cord-000180-howix091	192	33	2	2	CD
cord-000180-howix091	192	34	)	)	-RRB-
cord-000180-howix091	192	35	.	.	.
cord-000180-howix091	193	1	Arrows	arrow	NNS
cord-000180-howix091	193	2	in	in	IN
cord-000180-howix091	193	3	Figure	figure	NN
cord-000180-howix091	193	4	2	2	CD
cord-000180-howix091	193	5	indicate	indicate	VBP
cord-000180-howix091	193	6	the	the	DT
cord-000180-howix091	193	7	C	C	NNP
cord-000180-howix091	193	8	T	T	NNP
cord-000180-howix091	193	9	value	value	NN
cord-000180-howix091	193	10	for	for	IN
cord-000180-howix091	193	11	each	each	DT
cord-000180-howix091	193	12	of	of	IN
cord-000180-howix091	193	13	the	the	DT
cord-000180-howix091	193	14	four	four	CD
cord-000180-howix091	193	15	targets	target	NNS
cord-000180-howix091	193	16	examined	examine	VBN
cord-000180-howix091	193	17	.	.	.
cord-000180-howix091	194	1	Inoculation	inoculation	NN
cord-000180-howix091	194	2	with	with	IN
cord-000180-howix091	194	3	1	1	CD
cord-000180-howix091	194	4	particle	particle	NN
cord-000180-howix091	194	5	cell	cell	NN
cord-000180-howix091	194	6	gave	give	VBD
cord-000180-howix091	194	7	no	no	DT
cord-000180-howix091	194	8	detectable	detectable	JJ
cord-000180-howix091	194	9	increase	increase	NN
cord-000180-howix091	194	10	in	in	IN
cord-000180-howix091	194	11	transcript	transcript	NN
cord-000180-howix091	194	12	abundance	abundance	NN
cord-000180-howix091	194	13	but	but	CC
cord-000180-howix091	194	14	an	an	DT
cord-000180-howix091	194	15	increase	increase	NN
cord-000180-howix091	194	16	was	be	VBD
cord-000180-howix091	194	17	observed	observe	VBN
cord-000180-howix091	194	18	using	use	VBG
cord-000180-howix091	194	19	10	10	CD
cord-000180-howix091	194	20	particles	particle	NNS
cord-000180-howix091	194	21	per	per	IN
cord-000180-howix091	194	22	cell	cell	NN
cord-000180-howix091	194	23	and	and	CC
cord-000180-howix091	194	24	the	the	DT
cord-000180-howix091	194	25	dose	dose	JJ
cord-000180-howix091	194	26	response	response	NN
cord-000180-howix091	194	27	curves	curve	NNS
cord-000180-howix091	194	28	strongly	strongly	RB
cord-000180-howix091	194	29	suggest	suggest	VBP
cord-000180-howix091	194	30	that	that	IN
cord-000180-howix091	194	31	lower	low	JJR
cord-000180-howix091	194	32	doses	dose	NNS
cord-000180-howix091	194	33	have	have	VBP
cord-000180-howix091	194	34	an	an	DT
cord-000180-howix091	194	35	effect	effect	NN
cord-000180-howix091	194	36	.	.	.
cord-000180-howix091	195	1	Interpreting	interpret	VBG
cord-000180-howix091	195	2	these	these	DT
cord-000180-howix091	195	3	data	datum	NNS
cord-000180-howix091	195	4	in	in	IN
cord-000180-howix091	195	5	the	the	DT
cord-000180-howix091	195	6	context	context	NN
cord-000180-howix091	195	7	of	of	IN
cord-000180-howix091	195	8	infection	infection	NN
cord-000180-howix091	195	9	is	be	VBZ
cord-000180-howix091	195	10	not	not	RB
cord-000180-howix091	195	11	straightforward	straightforward	JJ
cord-000180-howix091	195	12	as	as	IN
cord-000180-howix091	195	13	particle	particle	NN
cord-000180-howix091	195	14	:	:	:
cord-000180-howix091	195	15	infectivity	infectivity	NN
cord-000180-howix091	195	16	ratios	ratio	NNS
cord-000180-howix091	195	17	for	for	IN
cord-000180-howix091	195	18	herpes	herpes	NN
cord-000180-howix091	195	19	simplex	simplex	NNP
cord-000180-howix091	195	20	virus	virus	NN
cord-000180-howix091	195	21	are	be	VBP
cord-000180-howix091	195	22	,	,	,
cord-000180-howix091	195	23	at	at	IN
cord-000180-howix091	195	24	best	good	JJS
cord-000180-howix091	195	25	,	,	,
cord-000180-howix091	195	26	20	20	CD
cord-000180-howix091	195	27	or	or	CC
cord-000180-howix091	195	28	more	more	JJR
cord-000180-howix091	195	29	.	.	.
cord-000180-howix091	196	1	On	on	IN
cord-000180-howix091	196	2	this	this	DT
cord-000180-howix091	196	3	basis	basis	NN
cord-000180-howix091	196	4	a	a	DT
cord-000180-howix091	196	5	single	single	JJ
cord-000180-howix091	196	6	infectious	infectious	JJ
cord-000180-howix091	196	7	unit	unit	NN
cord-000180-howix091	196	8	per	per	IN
cord-000180-howix091	196	9	cell	cell	NN
cord-000180-howix091	196	10	is	be	VBZ
cord-000180-howix091	196	11	clearly	clearly	RB
cord-000180-howix091	196	12	sufficient	sufficient	JJ
cord-000180-howix091	196	13	to	to	TO
cord-000180-howix091	196	14	increase	increase	VB
cord-000180-howix091	196	15	transcript	transcript	NN
cord-000180-howix091	196	16	abundance	abundance	NN
cord-000180-howix091	196	17	,	,	,
cord-000180-howix091	196	18	indicating	indicate	VBG
cord-000180-howix091	196	19	that	that	IN
cord-000180-howix091	196	20	signalling	signalling	NN
cord-000180-howix091	196	21	occurs	occur	VBZ
cord-000180-howix091	196	22	at	at	IN
cord-000180-howix091	196	23	'	'	``
cord-000180-howix091	196	24	physiological	physiological	JJ
cord-000180-howix091	196	25	'	'	''
cord-000180-howix091	196	26	multiplicities	multiplicity	NNS
cord-000180-howix091	196	27	of	of	IN
cord-000180-howix091	196	28	infection	infection	NN
cord-000180-howix091	196	29	.	.	.
cord-000180-howix091	197	1	Evidence	evidence	NN
cord-000180-howix091	197	2	from	from	IN
cord-000180-howix091	197	3	previous	previous	JJ
cord-000180-howix091	197	4	studies	study	NNS
cord-000180-howix091	197	5	using	use	VBG
cord-000180-howix091	197	6	soluble	soluble	JJ
cord-000180-howix091	197	7	HSV-1	hsv-1	NN
cord-000180-howix091	197	8	glycoprotein	glycoprotein	NN
cord-000180-howix091	197	9	and	and	CC
cord-000180-howix091	197	10	UV	uv	NN
cord-000180-howix091	197	11	-	-	HYPH
cord-000180-howix091	197	12	inactivated	inactivate	VBN
cord-000180-howix091	197	13	virus	virus	NN
cord-000180-howix091	197	14	suggested	suggest	VBD
cord-000180-howix091	197	15	that	that	IN
cord-000180-howix091	197	16	binding	binding	NN
cord-000180-howix091	197	17	of	of	IN
cord-000180-howix091	197	18	HSV-1	hsv-1	NN
cord-000180-howix091	197	19	virions	virion	NNS
cord-000180-howix091	197	20	to	to	IN
cord-000180-howix091	197	21	the	the	DT
cord-000180-howix091	197	22	cell	cell	NN
cord-000180-howix091	197	23	surface	surface	NN
cord-000180-howix091	197	24	might	may	MD
cord-000180-howix091	197	25	be	be	VB
cord-000180-howix091	197	26	sufficient	sufficient	JJ
cord-000180-howix091	197	27	to	to	TO
cord-000180-howix091	197	28	stimulate	stimulate	VB
cord-000180-howix091	197	29	intracellular	intracellular	JJ
cord-000180-howix091	197	30	signalling	signal	VBG
cord-000180-howix091	197	31	pathways	pathway	NNS
cord-000180-howix091	197	32	.	.	.
cord-000180-howix091	198	1	We	-PRON-	PRP
cord-000180-howix091	198	2	undertook	undertake	VBD
cord-000180-howix091	198	3	preliminary	preliminary	JJ
cord-000180-howix091	198	4	microarray	microarray	NN
cord-000180-howix091	198	5	studies	study	NNS
cord-000180-howix091	198	6	with	with	IN
cord-000180-howix091	198	7	entry	entry	NN
cord-000180-howix091	198	8	-	-	HYPH
cord-000180-howix091	198	9	defective	defective	JJ
cord-000180-howix091	198	10	HSV-1	HSV-1	NNP
cord-000180-howix091	198	11	virions	virion	NNS
cord-000180-howix091	198	12	and	and	CC
cord-000180-howix091	198	13	identified	identify	VBD
cord-000180-howix091	198	14	a	a	DT
cord-000180-howix091	198	15	number	number	NN
cord-000180-howix091	198	16	of	of	IN
cord-000180-howix091	198	17	pathways	pathway	NNS
cord-000180-howix091	198	18	that	that	WDT
cord-000180-howix091	198	19	were	be	VBD
cord-000180-howix091	198	20	stimulated	stimulate	VBN
cord-000180-howix091	198	21	at	at	IN
cord-000180-howix091	198	22	early	early	JJ
cord-000180-howix091	198	23	time	time	NN
cord-000180-howix091	198	24	points	point	NNS
cord-000180-howix091	198	25	during	during	IN
cord-000180-howix091	198	26	infection	infection	NN
cord-000180-howix091	198	27	.	.	.
cord-000180-howix091	199	1	Microarray	microarray	JJ
cord-000180-howix091	199	2	experiments	experiment	NNS
cord-000180-howix091	199	3	are	be	VBP
cord-000180-howix091	199	4	inevitably	inevitably	RB
cord-000180-howix091	199	5	vulnerable	vulnerable	JJ
cord-000180-howix091	199	6	to	to	IN
cord-000180-howix091	199	7	false	false	JJ
cord-000180-howix091	199	8	positives	positive	NNS
cord-000180-howix091	199	9	and	and	CC
cord-000180-howix091	199	10	negatives	negative	NNS
cord-000180-howix091	199	11	due	due	JJ
cord-000180-howix091	199	12	to	to	IN
cord-000180-howix091	199	13	non	non	JJ
cord-000180-howix091	199	14	-	-	JJ
cord-000180-howix091	199	15	specific	specific	JJ
cord-000180-howix091	199	16	binding	binding	NN
cord-000180-howix091	199	17	of	of	IN
cord-000180-howix091	199	18	labelled	label	VBN
cord-000180-howix091	199	19	cDNA	cdna	NN
cord-000180-howix091	199	20	probes	probe	NNS
cord-000180-howix091	199	21	,	,	,
cord-000180-howix091	199	22	necessitating	necessitate	VBG
cord-000180-howix091	199	23	a	a	DT
cord-000180-howix091	199	24	more	more	RBR
cord-000180-howix091	199	25	robust	robust	JJ
cord-000180-howix091	199	26	follow	follow	NN
cord-000180-howix091	199	27	-	-	HYPH
cord-000180-howix091	199	28	up	up	NN
cord-000180-howix091	199	29	with	with	IN
cord-000180-howix091	199	30	highly	highly	RB
cord-000180-howix091	199	31	sensitive	sensitive	JJ
cord-000180-howix091	199	32	methods	method	NNS
cord-000180-howix091	199	33	.	.	.
cord-000180-howix091	200	1	Due	due	IN
cord-000180-howix091	200	2	to	to	IN
cord-000180-howix091	200	3	such	such	JJ
cord-000180-howix091	200	4	confounders	confounder	NNS
cord-000180-howix091	200	5	,	,	,
cord-000180-howix091	200	6	these	these	DT
cord-000180-howix091	200	7	data	datum	NNS
cord-000180-howix091	200	8	were	be	VBD
cord-000180-howix091	200	9	used	use	VBN
cord-000180-howix091	200	10	exclusively	exclusively	RB
cord-000180-howix091	200	11	as	as	IN
cord-000180-howix091	200	12	a	a	DT
cord-000180-howix091	200	13	guide	guide	NN
cord-000180-howix091	200	14	to	to	TO
cord-000180-howix091	200	15	select	select	VB
cord-000180-howix091	200	16	,	,	,
cord-000180-howix091	200	17	for	for	IN
cord-000180-howix091	200	18	real	real	JJ
cord-000180-howix091	200	19	-	-	HYPH
cord-000180-howix091	200	20	time	time	NN
cord-000180-howix091	200	21	PCR	PCR	NNP
cord-000180-howix091	200	22	,	,	,
cord-000180-howix091	200	23	the	the	DT
cord-000180-howix091	200	24	transcriptional	transcriptional	JJ
cord-000180-howix091	200	25	targets	target	NNS
cord-000180-howix091	200	26	of	of	IN
cord-000180-howix091	200	27	intracellular	intracellular	JJ
cord-000180-howix091	200	28	signalling	signal	VBG
cord-000180-howix091	200	29	pathways	pathway	NNS
cord-000180-howix091	200	30	stimulated	stimulate	VBN
cord-000180-howix091	200	31	after	after	IN
cord-000180-howix091	200	32	inoculation	inoculation	NN
cord-000180-howix091	200	33	with	with	IN
cord-000180-howix091	200	34	entry	entry	NN
cord-000180-howix091	200	35	-	-	HYPH
cord-000180-howix091	200	36	defective	defective	JJ
cord-000180-howix091	200	37	HSV-1	hsv-1	NN
cord-000180-howix091	200	38	.	.	.
cord-000180-howix091	201	1	Gene	gene	NN
cord-000180-howix091	201	2	targets	target	NNS
cord-000180-howix091	201	3	associated	associate	VBN
cord-000180-howix091	201	4	with	with	IN
cord-000180-howix091	201	5	the	the	DT
cord-000180-howix091	201	6	NF	NF	NNP
cord-000180-howix091	201	7	-	-	HYPH
cord-000180-howix091	201	8	kB	kB	NNP
cord-000180-howix091	201	9	,	,	,
cord-000180-howix091	201	10	JAK	JAK	NNP
cord-000180-howix091	201	11	/	/	SYM
cord-000180-howix091	201	12	STAT	STAT	NNP
cord-000180-howix091	201	13	/	/	SYM
cord-000180-howix091	201	14	Src	Src	NNP
cord-000180-howix091	201	15	,	,	,
cord-000180-howix091	201	16	and	and	CC
cord-000180-howix091	201	17	PI3K	PI3K	NNP
cord-000180-howix091	201	18	/	/	SYM
cord-000180-howix091	201	19	Akt	Akt	NNP
cord-000180-howix091	201	20	pathways	pathway	NNS
cord-000180-howix091	201	21	were	be	VBD
cord-000180-howix091	201	22	shown	show	VBN
cord-000180-howix091	201	23	to	to	TO
cord-000180-howix091	201	24	be	be	VB
cord-000180-howix091	201	25	differentially	differentially	RB
cord-000180-howix091	201	26	expressed	express	VBN
cord-000180-howix091	201	27	after	after	IN
cord-000180-howix091	201	28	inoculation	inoculation	NN
cord-000180-howix091	201	29	with	with	IN
cord-000180-howix091	201	30	glycoprotein	glycoprotein	NN
cord-000180-howix091	201	31	-	-	HYPH
cord-000180-howix091	201	32	deficient	deficient	JJ
cord-000180-howix091	201	33	virions	virion	NNS
cord-000180-howix091	201	34	,	,	,
cord-000180-howix091	201	35	with	with	IN
cord-000180-howix091	201	36	the	the	DT
cord-000180-howix091	201	37	majority	majority	NN
cord-000180-howix091	201	38	of	of	IN
cord-000180-howix091	201	39	signalling	signal	VBG
cord-000180-howix091	201	40	events	event	NNS
cord-000180-howix091	201	41	being	be	VBG
cord-000180-howix091	201	42	associated	associate	VBN
cord-000180-howix091	201	43	with	with	IN
cord-000180-howix091	201	44	the	the	DT
cord-000180-howix091	201	45	presence	presence	NN
cord-000180-howix091	201	46	of	of	IN
cord-000180-howix091	201	47	gD	gD	NNP
cord-000180-howix091	201	48	on	on	IN
cord-000180-howix091	201	49	the	the	DT
cord-000180-howix091	201	50	envelope	envelope	NN
cord-000180-howix091	201	51	.	.	.
cord-000180-howix091	202	1	Nineteen	nineteen	CD
cord-000180-howix091	202	2	other	other	JJ
cord-000180-howix091	202	3	signalling	signal	VBG
cord-000180-howix091	202	4	pathways	pathway	NNS
cord-000180-howix091	202	5	present	present	JJ
cord-000180-howix091	202	6	on	on	IN
cord-000180-howix091	202	7	the	the	DT
cord-000180-howix091	202	8	preliminary	preliminary	JJ
cord-000180-howix091	202	9	microarray	microarray	NN
cord-000180-howix091	202	10	experiments	experiment	NNS
cord-000180-howix091	202	11	,	,	,
cord-000180-howix091	202	12	and	and	CC
cord-000180-howix091	202	13	confirmed	confirm	VBN
cord-000180-howix091	202	14	by	by	IN
cord-000180-howix091	202	15	real	real	JJ
cord-000180-howix091	202	16	-	-	HYPH
cord-000180-howix091	202	17	time	time	NN
cord-000180-howix091	202	18	PCR	PCR	NNP
cord-000180-howix091	202	19	,	,	,
cord-000180-howix091	202	20	were	be	VBD
cord-000180-howix091	202	21	not	not	RB
cord-000180-howix091	202	22	stimulated	stimulate	VBN
cord-000180-howix091	202	23	(	(	-LRB-
cord-000180-howix091	202	24	data	datum	NNS
cord-000180-howix091	202	25	not	not	RB
cord-000180-howix091	202	26	shown	show	VBN
cord-000180-howix091	202	27	)	)	-RRB-
cord-000180-howix091	202	28	.	.	.
cord-000180-howix091	203	1	These	these	DT
cord-000180-howix091	203	2	results	result	NNS
cord-000180-howix091	203	3	are	be	VBP
cord-000180-howix091	203	4	compatible	compatible	JJ
cord-000180-howix091	203	5	with	with	IN
cord-000180-howix091	203	6	our	-PRON-	PRP$
cord-000180-howix091	203	7	model	model	NN
cord-000180-howix091	203	8	,	,	,
cord-000180-howix091	203	9	shown	show	VBN
cord-000180-howix091	203	10	in	in	IN
cord-000180-howix091	203	11	Fig	Fig	NNP
cord-000180-howix091	203	12	.	.	.
cord-000180-howix091	204	1	3	3	LS
cord-000180-howix091	204	2	.	.	.
cord-000180-howix091	205	1	Real	real	JJ
cord-000180-howix091	205	2	-	-	HYPH
cord-000180-howix091	205	3	time	time	NN
cord-000180-howix091	205	4	PCR	PCR	NNP
cord-000180-howix091	205	5	confirmed	confirm	VBD
cord-000180-howix091	205	6	that	that	IN
cord-000180-howix091	205	7	changes	change	NNS
cord-000180-howix091	205	8	in	in	IN
cord-000180-howix091	205	9	transcription	transcription	NN
cord-000180-howix091	205	10	associated	associate	VBN
cord-000180-howix091	205	11	with	with	IN
cord-000180-howix091	205	12	the	the	DT
cord-000180-howix091	205	13	NF	NF	NNP
cord-000180-howix091	205	14	-	-	HYPH
cord-000180-howix091	205	15	kB	kB	NNP
cord-000180-howix091	205	16	,	,	,
cord-000180-howix091	205	17	JAK	JAK	NNP
cord-000180-howix091	205	18	/	/	SYM
cord-000180-howix091	205	19	STAT	STAT	NNP
cord-000180-howix091	205	20	,	,	,
cord-000180-howix091	205	21	JAK	JAK	NNP
cord-000180-howix091	205	22	/	/	SYM
cord-000180-howix091	205	23	Src	Src	NNP
cord-000180-howix091	205	24	and	and	CC
cord-000180-howix091	205	25	PI3	PI3	NNP
cord-000180-howix091	205	26	K	K	NNP
cord-000180-howix091	205	27	pathways	pathway	NNS
cord-000180-howix091	205	28	were	be	VBD
cord-000180-howix091	205	29	modulated	modulate	VBN
cord-000180-howix091	205	30	as	as	IN
cord-000180-howix091	205	31	a	a	DT
cord-000180-howix091	205	32	result	result	NN
cord-000180-howix091	205	33	of	of	IN
cord-000180-howix091	205	34	virion	virion	NN
cord-000180-howix091	205	35	binding	binding	NN
cord-000180-howix091	205	36	,	,	,
cord-000180-howix091	205	37	all	all	DT
cord-000180-howix091	205	38	of	of	IN
cord-000180-howix091	205	39	which	which	WDT
cord-000180-howix091	205	40	required	require	VBD
cord-000180-howix091	205	41	gD	gD	NNP
cord-000180-howix091	205	42	on	on	IN
cord-000180-howix091	205	43	the	the	DT
cord-000180-howix091	205	44	envelope	envelope	NN
cord-000180-howix091	205	45	surface	surface	NN
cord-000180-howix091	205	46	To	to	TO
cord-000180-howix091	205	47	demonstrate	demonstrate	VB
cord-000180-howix091	205	48	that	that	IN
cord-000180-howix091	205	49	signalling	signal	VBG
cord-000180-howix091	205	50	occurred	occur	VBD
cord-000180-howix091	205	51	at	at	IN
cord-000180-howix091	205	52	physiologically	physiologically	RB
cord-000180-howix091	205	53	relevant	relevant	JJ
cord-000180-howix091	205	54	multiplicities	multiplicity	NNS
cord-000180-howix091	205	55	of	of	IN
cord-000180-howix091	205	56	infection	infection	NN
cord-000180-howix091	205	57	,	,	,
cord-000180-howix091	205	58	HFFs	HFFs	NNP
cord-000180-howix091	205	59	were	be	VBD
cord-000180-howix091	205	60	inoculated	inoculate	VBN
cord-000180-howix091	205	61	with	with	IN
cord-000180-howix091	205	62	either	either	DT
cord-000180-howix091	205	63	1000	1000	CD
cord-000180-howix091	205	64	,	,	,
cord-000180-howix091	205	65	100	100	CD
cord-000180-howix091	205	66	,	,	,
cord-000180-howix091	205	67	10	10	CD
cord-000180-howix091	205	68	or	or	CC
cord-000180-howix091	205	69	1	1	CD
cord-000180-howix091	205	70	particles	particle	NNS
cord-000180-howix091	205	71	per	per	IN
cord-000180-howix091	205	72	cell	cell	NN
cord-000180-howix091	205	73	of	of	IN
cord-000180-howix091	205	74	entry	entry	NN
cord-000180-howix091	205	75	-	-	HYPH
cord-000180-howix091	205	76	defective	defective	JJ
cord-000180-howix091	205	77	HSV-1	hsv-1	NN
cord-000180-howix091	205	78	.	.	.
cord-000180-howix091	206	1	Changes	change	NNS
cord-000180-howix091	206	2	in	in	IN
cord-000180-howix091	206	3	gene	gene	NN
cord-000180-howix091	206	4	transcription	transcription	NN
cord-000180-howix091	206	5	occurred	occur	VBD
cord-000180-howix091	206	6	in	in	IN
cord-000180-howix091	206	7	a	a	DT
cord-000180-howix091	206	8	dose	dose	NN
cord-000180-howix091	206	9	-	-	HYPH
cord-000180-howix091	206	10	dependent	dependent	JJ
cord-000180-howix091	206	11	manner	manner	NN
cord-000180-howix091	206	12	and	and	CC
cord-000180-howix091	206	13	were	be	VBD
cord-000180-howix091	206	14	detectable	detectable	JJ
cord-000180-howix091	206	15	at	at	IN
cord-000180-howix091	206	16	10	10	CD
cord-000180-howix091	206	17	virus	virus	NN
cord-000180-howix091	206	18	particles	particle	NNS
cord-000180-howix091	206	19	per	per	IN
cord-000180-howix091	206	20	cell	cell	NN
cord-000180-howix091	206	21	.	.	.
cord-000180-howix091	207	1	Given	give	VBN
cord-000180-howix091	207	2	the	the	DT
cord-000180-howix091	207	3	particle	particle	NN
cord-000180-howix091	207	4	:	:	:
cord-000180-howix091	207	5	infectivity	infectivity	NN
cord-000180-howix091	207	6	ratios	ratio	NNS
cord-000180-howix091	207	7	usually	usually	RB
cord-000180-howix091	207	8	quoted	quote	VBN
cord-000180-howix091	207	9	for	for	IN
cord-000180-howix091	207	10	HSV1	HSV1	NNP
cord-000180-howix091	207	11	,	,	,
cord-000180-howix091	207	12	we	-PRON-	PRP
cord-000180-howix091	207	13	argue	argue	VBP
cord-000180-howix091	207	14	that	that	IN
cord-000180-howix091	207	15	this	this	DT
cord-000180-howix091	207	16	corresponds	correspond	VBZ
cord-000180-howix091	207	17	to	to	IN
cord-000180-howix091	207	18	physiological	physiological	JJ
cord-000180-howix091	207	19	conditions	condition	NNS
cord-000180-howix091	207	20	(	(	-LRB-
cord-000180-howix091	207	21	i.e.	i.e.	FW
cord-000180-howix091	207	22	less	less	JJR
cord-000180-howix091	207	23	than	than	IN
cord-000180-howix091	207	24	one	one	CD
cord-000180-howix091	207	25	infectious	infectious	JJ
cord-000180-howix091	207	26	unit	unit	NN
cord-000180-howix091	207	27	per	per	IN
cord-000180-howix091	207	28	cell	cell	NN
cord-000180-howix091	207	29	)	)	-RRB-
cord-000180-howix091	207	30	,	,	,
cord-000180-howix091	207	31	but	but	CC
cord-000180-howix091	207	32	it	-PRON-	PRP
cord-000180-howix091	207	33	is	be	VBZ
cord-000180-howix091	207	34	impossible	impossible	JJ
cord-000180-howix091	207	35	to	to	TO
cord-000180-howix091	207	36	know	know	VB
cord-000180-howix091	207	37	the	the	DT
cord-000180-howix091	207	38	circumstances	circumstance	NNS
cord-000180-howix091	207	39	that	that	WDT
cord-000180-howix091	207	40	pertain	pertain	VBP
cord-000180-howix091	207	41	in	in	IN
cord-000180-howix091	207	42	vivo	vivo	NN
cord-000180-howix091	207	43	when	when	WRB
cord-000180-howix091	207	44	a	a	DT
cord-000180-howix091	207	45	single	single	JJ
cord-000180-howix091	207	46	cell	cell	NN
cord-000180-howix091	207	47	becomes	become	VBZ
cord-000180-howix091	207	48	infected	infected	JJ
cord-000180-howix091	207	49	.	.	.
cord-000180-howix091	208	1	What	what	WP
cord-000180-howix091	208	2	seems	seem	VBZ
cord-000180-howix091	208	3	almost	almost	RB
cord-000180-howix091	208	4	certain	certain	JJ
cord-000180-howix091	208	5	is	be	VBZ
cord-000180-howix091	208	6	that	that	IN
cord-000180-howix091	208	7	an	an	DT
cord-000180-howix091	208	8	infected	infected	JJ
cord-000180-howix091	208	9	cell	cell	NN
cord-000180-howix091	208	10	will	will	MD
cord-000180-howix091	208	11	normally	normally	RB
cord-000180-howix091	208	12	present	present	VB
cord-000180-howix091	208	13	an	an	DT
cord-000180-howix091	208	14	uninfected	uninfected	JJ
cord-000180-howix091	208	15	neighbouring	neighbouring	JJ
cord-000180-howix091	208	16	cell	cell	NN
cord-000180-howix091	208	17	with	with	IN
cord-000180-howix091	208	18	10	10	CD
cord-000180-howix091	208	19	or	or	CC
cord-000180-howix091	208	20	more	more	JJR
cord-000180-howix091	208	21	progeny	progeny	JJ
cord-000180-howix091	208	22	particles	particle	NNS
cord-000180-howix091	208	23	.	.	.
cord-000180-howix091	209	1	HSV-1	hsv-1	NN
cord-000180-howix091	209	2	,	,	,
cord-000180-howix091	209	3	as	as	RB
cord-000180-howix091	209	4	well	well	RB
cord-000180-howix091	209	5	as	as	IN
cord-000180-howix091	209	6	beta	beta	NN
cord-000180-howix091	209	7	-	-	:
cord-000180-howix091	209	8	and	and	CC
cord-000180-howix091	209	9	gammaherpesviruses	gammaherpesviruse	NNS
cord-000180-howix091	209	10	,	,	,
cord-000180-howix091	209	11	are	be	VBP
cord-000180-howix091	209	12	capable	capable	JJ
cord-000180-howix091	209	13	of	of	IN
cord-000180-howix091	209	14	stimulating	stimulate	VBG
cord-000180-howix091	209	15	the	the	DT
cord-000180-howix091	209	16	NF	NF	NNP
cord-000180-howix091	209	17	-	-	HYPH
cord-000180-howix091	209	18	kB	kB	NNP
cord-000180-howix091	209	19	pathway	pathway	NN
cord-000180-howix091	209	20	in	in	IN
cord-000180-howix091	209	21	a	a	DT
cord-000180-howix091	209	22	bi	bi	JJ
cord-000180-howix091	209	23	-	-	JJ
cord-000180-howix091	209	24	phasic	phasic	JJ
cord-000180-howix091	209	25	manner	manner	NN
cord-000180-howix091	209	26	,	,	,
cord-000180-howix091	209	27	with	with	IN
cord-000180-howix091	209	28	our	-PRON-	PRP$
cord-000180-howix091	209	29	data	datum	NNS
cord-000180-howix091	209	30	supporting	support	VBG
cord-000180-howix091	209	31	that	that	IN
cord-000180-howix091	209	32	an	an	DT
cord-000180-howix091	209	33	early	early	JJ
cord-000180-howix091	209	34	,	,	,
cord-000180-howix091	209	35	transient	transient	JJ
cord-000180-howix091	209	36	induction	induction	NN
cord-000180-howix091	209	37	is	be	VBZ
cord-000180-howix091	209	38	reliant	reliant	JJ
cord-000180-howix091	209	39	on	on	IN
cord-000180-howix091	209	40	virions	virion	NNS
cord-000180-howix091	209	41	expressing	express	VBG
cord-000180-howix091	209	42	gD	gD	NNP
cord-000180-howix091	209	43	[	[	-LRB-
cord-000180-howix091	209	44	8	8	CD
cord-000180-howix091	209	45	]	]	-RRB-
cord-000180-howix091	209	46	[	[	-LRB-
cord-000180-howix091	209	47	32	32	CD
cord-000180-howix091	209	48	]	]	-RRB-
cord-000180-howix091	209	49	[	[	-LRB-
cord-000180-howix091	209	50	33	33	CD
cord-000180-howix091	209	51	]	]	-RRB-
cord-000180-howix091	209	52	.	.	.
cord-000180-howix091	210	1	Suppression	suppression	NN
cord-000180-howix091	210	2	of	of	IN
cord-000180-howix091	210	3	NF	NF	NNP
cord-000180-howix091	210	4	-	-	HYPH
cord-000180-howix091	210	5	kB	kb	CD
cord-000180-howix091	210	6	activity	activity	NN
cord-000180-howix091	210	7	is	be	VBZ
cord-000180-howix091	210	8	via	via	IN
cord-000180-howix091	210	9	negative	negative	JJ
cord-000180-howix091	210	10	feedback	feedback	NN
cord-000180-howix091	210	11	up	up	IN
cord-000180-howix091	210	12	-	-	HYPH
cord-000180-howix091	210	13	regulation	regulation	NN
cord-000180-howix091	210	14	of	of	IN
cord-000180-howix091	210	15	the	the	DT
cord-000180-howix091	210	16	inhibitor	inhibitor	NN
cord-000180-howix091	210	17	IkBa	IkBa	NNP
cord-000180-howix091	210	18	(	(	-LRB-
cord-000180-howix091	210	19	nfkbia	nfkbia	NNP
cord-000180-howix091	210	20	)	)	-RRB-
cord-000180-howix091	210	21	,	,	,
cord-000180-howix091	210	22	which	which	WDT
cord-000180-howix091	210	23	was	be	VBD
cord-000180-howix091	210	24	also	also	RB
cord-000180-howix091	210	25	stimulated	stimulate	VBN
cord-000180-howix091	210	26	by	by	IN
cord-000180-howix091	210	27	the	the	DT
cord-000180-howix091	210	28	binding	binding	NN
cord-000180-howix091	210	29	of	of	IN
cord-000180-howix091	210	30	entry	entry	NN
cord-000180-howix091	210	31	-	-	HYPH
cord-000180-howix091	210	32	defective	defective	JJ
cord-000180-howix091	210	33	HSV-1	HSV-1	NNP
cord-000180-howix091	210	34	virions	virion	NNS
cord-000180-howix091	210	35	.	.	.
cord-000180-howix091	211	1	The	the	DT
cord-000180-howix091	211	2	triggering	triggering	NN
cord-000180-howix091	211	3	of	of	IN
cord-000180-howix091	211	4	early	early	JJ
cord-000180-howix091	211	5	NF	nf	NN
cord-000180-howix091	211	6	-	-	HYPH
cord-000180-howix091	211	7	kB	kb	CD
cord-000180-howix091	211	8	transcriptional	transcriptional	JJ
cord-000180-howix091	211	9	activity	activity	NN
cord-000180-howix091	211	10	was	be	VBD
cord-000180-howix091	211	11	most	most	RBS
cord-000180-howix091	211	12	likely	likely	JJ
cord-000180-howix091	211	13	through	through	IN
cord-000180-howix091	211	14	the	the	DT
cord-000180-howix091	211	15	coupling	coupling	NN
cord-000180-howix091	211	16	of	of	IN
cord-000180-howix091	211	17	gD	gd	NN
cord-000180-howix091	211	18	on	on	IN
cord-000180-howix091	211	19	entry	entry	NN
cord-000180-howix091	211	20	-	-	HYPH
cord-000180-howix091	211	21	defective	defective	JJ
cord-000180-howix091	211	22	virions	virion	NNS
cord-000180-howix091	211	23	to	to	IN
cord-000180-howix091	211	24	the	the	DT
cord-000180-howix091	211	25	TNF	TNF	NNP
cord-000180-howix091	211	26	superfamily	superfamily	NN
cord-000180-howix091	211	27	receptor	receptor	NN
cord-000180-howix091	211	28	HvEM	HvEM	NNP
cord-000180-howix091	211	29	[	[	-LRB-
cord-000180-howix091	211	30	1	1	CD
cord-000180-howix091	211	31	]	]	-RRB-
cord-000180-howix091	211	32	.	.	.
cord-000180-howix091	212	1	In	in	IN
cord-000180-howix091	212	2	doing	do	VBG
cord-000180-howix091	212	3	so	so	RB
cord-000180-howix091	212	4	,	,	,
cord-000180-howix091	212	5	not	not	RB
cord-000180-howix091	212	6	only	only	RB
cord-000180-howix091	212	7	does	do	VBZ
cord-000180-howix091	212	8	the	the	DT
cord-000180-howix091	212	9	initial	initial	JJ
cord-000180-howix091	212	10	activation	activation	NN
cord-000180-howix091	212	11	of	of	IN
cord-000180-howix091	212	12	this	this	DT
cord-000180-howix091	212	13	pathway	pathway	NN
cord-000180-howix091	212	14	allow	allow	VBP
cord-000180-howix091	212	15	for	for	IN
cord-000180-howix091	212	16	the	the	DT
cord-000180-howix091	212	17	subsequent	subsequent	JJ
cord-000180-howix091	212	18	sequestration	sequestration	NN
cord-000180-howix091	212	19	of	of	IN
cord-000180-howix091	212	20	the	the	DT
cord-000180-howix091	212	21	NF	NF	NNP
cord-000180-howix091	212	22	-	-	HYPH
cord-000180-howix091	212	23	kB	kB	NNP
cord-000180-howix091	212	24	p65	p65	NN
cord-000180-howix091	212	25	subunit	subunit	NN
cord-000180-howix091	212	26	to	to	IN
cord-000180-howix091	212	27	the	the	DT
cord-000180-howix091	212	28	ICP0	ICP0	NNP
cord-000180-howix091	212	29	promoter	promoter	NN
cord-000180-howix091	212	30	,	,	,
cord-000180-howix091	212	31	but	but	CC
cord-000180-howix091	212	32	is	be	VBZ
cord-000180-howix091	212	33	crucial	crucial	JJ
cord-000180-howix091	212	34	for	for	IN
cord-000180-howix091	212	35	immediate	immediate	JJ
cord-000180-howix091	212	36	-	-	HYPH
cord-000180-howix091	212	37	early	early	JJ
cord-000180-howix091	212	38	gene	gene	NN
cord-000180-howix091	212	39	transcription	transcription	NN
cord-000180-howix091	212	40	and	and	CC
cord-000180-howix091	212	41	subsequent	subsequent	JJ
cord-000180-howix091	212	42	HSV-1	hsv-1	NN
cord-000180-howix091	212	43	replication	replication	NN
cord-000180-howix091	212	44	[	[	-LRB-
cord-000180-howix091	212	45	8	8	CD
cord-000180-howix091	212	46	]	]	-RRB-
cord-000180-howix091	212	47	.	.	.
cord-000180-howix091	213	1	Intracellular	Intracellular	NNP
cord-000180-howix091	213	2	signalling	signal	VBG
cord-000180-howix091	213	3	induced	induce	VBN
cord-000180-howix091	213	4	by	by	IN
cord-000180-howix091	213	5	soluble	soluble	JJ
cord-000180-howix091	213	6	gD	gD	NNP
cord-000180-howix091	213	7	can	can	MD
cord-000180-howix091	213	8	protect	protect	VB
cord-000180-howix091	213	9	against	against	IN
cord-000180-howix091	213	10	Fas	Fas	NNP
cord-000180-howix091	213	11	-	-	HYPH
cord-000180-howix091	213	12	mediated	mediate	VBN
cord-000180-howix091	213	13	apoptosis	apoptosis	NN
cord-000180-howix091	213	14	with	with	IN
cord-000180-howix091	213	15	inhibition	inhibition	NN
cord-000180-howix091	213	16	of	of	IN
cord-000180-howix091	213	17	NF	NF	NNP
cord-000180-howix091	213	18	-	-	HYPH
cord-000180-howix091	213	19	kB	kB	NNP
cord-000180-howix091	213	20	signalling	signal	VBG
cord-000180-howix091	213	21	leading	lead	VBG
cord-000180-howix091	213	22	to	to	IN
cord-000180-howix091	213	23	a	a	DT
cord-000180-howix091	213	24	loss	loss	NN
cord-000180-howix091	213	25	of	of	IN
cord-000180-howix091	213	26	this	this	DT
cord-000180-howix091	213	27	protection	protection	NN
cord-000180-howix091	213	28	[	[	-LRB-
cord-000180-howix091	213	29	6	6	CD
cord-000180-howix091	213	30	]	]	-RRB-
cord-000180-howix091	213	31	.	.	.
cord-000180-howix091	214	1	Infection	infection	NN
cord-000180-howix091	214	2	with	with	IN
cord-000180-howix091	214	3	UV	uv	NN
cord-000180-howix091	214	4	-	-	HYPH
cord-000180-howix091	214	5	inactivated	inactivate	VBN
cord-000180-howix091	214	6	virions	virion	NNS
cord-000180-howix091	214	7	also	also	RB
cord-000180-howix091	214	8	led	lead	VBD
cord-000180-howix091	214	9	to	to	IN
cord-000180-howix091	214	10	an	an	DT
cord-000180-howix091	214	11	increase	increase	NN
cord-000180-howix091	214	12	in	in	IN
cord-000180-howix091	214	13	the	the	DT
cord-000180-howix091	214	14	expression	expression	NN
cord-000180-howix091	214	15	of	of	IN
cord-000180-howix091	214	16	the	the	DT
cord-000180-howix091	214	17	anti	anti	JJ
cord-000180-howix091	214	18	-	-	JJ
cord-000180-howix091	214	19	apoptotic	apoptotic	JJ
cord-000180-howix091	214	20	protein	protein	NN
cord-000180-howix091	214	21	c	c	NN
cord-000180-howix091	214	22	-	-	:
cord-000180-howix091	214	23	IAP2	IAP2	NNP
cord-000180-howix091	214	24	(	(	-LRB-
cord-000180-howix091	214	25	birc3	birc3	NNP
cord-000180-howix091	214	26	)	)	-RRB-
cord-000180-howix091	214	27	,	,	,
cord-000180-howix091	214	28	which	which	WDT
cord-000180-howix091	214	29	we	-PRON-	PRP
cord-000180-howix091	214	30	have	have	VBP
cord-000180-howix091	214	31	demonstrated	demonstrate	VBN
cord-000180-howix091	214	32	to	to	TO
cord-000180-howix091	214	33	be	be	VB
cord-000180-howix091	214	34	up	up	RB
cord-000180-howix091	214	35	-	-	HYPH
cord-000180-howix091	214	36	regulated	regulate	VBN
cord-000180-howix091	214	37	after	after	IN
cord-000180-howix091	214	38	inoculation	inoculation	NN
cord-000180-howix091	214	39	with	with	IN
cord-000180-howix091	214	40	entry	entry	NN
cord-000180-howix091	214	41	-	-	HYPH
cord-000180-howix091	214	42	defective	defective	JJ
cord-000180-howix091	214	43	virions	virion	NNS
cord-000180-howix091	214	44	containing	contain	VBG
cord-000180-howix091	214	45	gD.	gD.	NNS
cord-000180-howix091	214	46	Additional	additional	JJ
cord-000180-howix091	214	47	studies	study	NNS
cord-000180-howix091	214	48	have	have	VBP
cord-000180-howix091	214	49	supported	support	VBN
cord-000180-howix091	214	50	the	the	DT
cord-000180-howix091	214	51	anti	anti	JJ
cord-000180-howix091	214	52	-	-	JJ
cord-000180-howix091	214	53	apoptotic	apoptotic	JJ
cord-000180-howix091	214	54	role	role	NN
cord-000180-howix091	214	55	for	for	IN
cord-000180-howix091	214	56	NF	NF	NNP
cord-000180-howix091	214	57	-	-	HYPH
cord-000180-howix091	214	58	kB	kB	NNP
cord-000180-howix091	214	59	during	during	IN
cord-000180-howix091	214	60	HSV-1	HSV-1	NNS
cord-000180-howix091	214	61	infection	infection	NN
cord-000180-howix091	214	62	yet	yet	CC
cord-000180-howix091	214	63	there	there	EX
cord-000180-howix091	214	64	are	be	VBP
cord-000180-howix091	214	65	conflicting	conflict	VBG
cord-000180-howix091	214	66	data	datum	NNS
cord-000180-howix091	214	67	that	that	WDT
cord-000180-howix091	214	68	demonstrate	demonstrate	VBP
cord-000180-howix091	214	69	possible	possible	JJ
cord-000180-howix091	214	70	pro	pro	JJ
cord-000180-howix091	214	71	-	-	JJ
cord-000180-howix091	214	72	apoptotic	apoptotic	JJ
cord-000180-howix091	214	73	activity	activity	NN
cord-000180-howix091	214	74	[	[	-LRB-
cord-000180-howix091	214	75	34	34	CD
cord-000180-howix091	214	76	]	]	-RRB-
cord-000180-howix091	214	77	[	[	-LRB-
cord-000180-howix091	214	78	35	35	CD
cord-000180-howix091	214	79	]	]	-RRB-
cord-000180-howix091	214	80	.	.	.
cord-000180-howix091	215	1	This	this	DT
cord-000180-howix091	215	2	inconsistency	inconsistency	NN
cord-000180-howix091	215	3	may	may	MD
cord-000180-howix091	215	4	be	be	VB
cord-000180-howix091	215	5	due	due	JJ
cord-000180-howix091	215	6	to	to	IN
cord-000180-howix091	215	7	differing	differ	VBG
cord-000180-howix091	215	8	cell	cell	NN
cord-000180-howix091	215	9	types	type	NNS
cord-000180-howix091	215	10	used	use	VBN
cord-000180-howix091	215	11	in	in	IN
cord-000180-howix091	215	12	those	those	DT
cord-000180-howix091	215	13	studies	study	NNS
cord-000180-howix091	215	14	.	.	.
cord-000180-howix091	216	1	Primary	primary	JJ
cord-000180-howix091	216	2	human	human	JJ
cord-000180-howix091	216	3	foreskin	foreskin	NN
cord-000180-howix091	216	4	fibroblasts	fibroblast	NNS
cord-000180-howix091	216	5	have	have	VBP
cord-000180-howix091	216	6	been	be	VBN
cord-000180-howix091	216	7	shown	show	VBN
cord-000180-howix091	216	8	to	to	TO
cord-000180-howix091	216	9	be	be	VB
cord-000180-howix091	216	10	resistant	resistant	JJ
cord-000180-howix091	216	11	to	to	IN
cord-000180-howix091	216	12	apoptosis	apoptosis	NN
cord-000180-howix091	216	13	after	after	IN
cord-000180-howix091	216	14	infection	infection	NN
cord-000180-howix091	216	15	with	with	IN
cord-000180-howix091	216	16	recombinant	recombinant	JJ
cord-000180-howix091	216	17	HSV-1	hsv-1	NN
cord-000180-howix091	216	18	that	that	WDT
cord-000180-howix091	216	19	is	be	VBZ
cord-000180-howix091	216	20	unable	unable	JJ
cord-000180-howix091	216	21	to	to	TO
cord-000180-howix091	216	22	express	express	VB
cord-000180-howix091	216	23	ICP4	ICP4	NNP
cord-000180-howix091	216	24	or	or	CC
cord-000180-howix091	216	25	ICP27	ICP27	NNP
cord-000180-howix091	216	26	whereas	whereas	IN
cord-000180-howix091	216	27	infection	infection	NN
cord-000180-howix091	216	28	with	with	IN
cord-000180-howix091	216	29	either	either	DT
cord-000180-howix091	216	30	virus	virus	NN
cord-000180-howix091	216	31	has	have	VBZ
cord-000180-howix091	216	32	been	be	VBN
cord-000180-howix091	216	33	shown	show	VBN
cord-000180-howix091	216	34	to	to	TO
cord-000180-howix091	216	35	cause	cause	VB
cord-000180-howix091	216	36	apoptosis	apoptosis	NN
cord-000180-howix091	216	37	in	in	IN
cord-000180-howix091	216	38	transformed	transformed	JJ
cord-000180-howix091	216	39	cell	cell	NN
cord-000180-howix091	216	40	lines	line	NNS
cord-000180-howix091	216	41	[	[	-LRB-
cord-000180-howix091	216	42	36	36	CD
cord-000180-howix091	216	43	]	]	-RRB-
cord-000180-howix091	216	44	.	.	.
cord-000180-howix091	217	1	Aspects	aspect	NNS
cord-000180-howix091	217	2	of	of	IN
cord-000180-howix091	217	3	the	the	DT
cord-000180-howix091	217	4	HSV-1	HSV-1	NNP
cord-000180-howix091	217	5	life	life	NN
cord-000180-howix091	217	6	cycle	cycle	NN
cord-000180-howix091	217	7	,	,	,
cord-000180-howix091	217	8	such	such	JJ
cord-000180-howix091	217	9	as	as	IN
cord-000180-howix091	217	10	stimulating	stimulate	VBG
cord-000180-howix091	217	11	the	the	DT
cord-000180-howix091	217	12	progression	progression	NN
cord-000180-howix091	217	13	of	of	IN
cord-000180-howix091	217	14	the	the	DT
cord-000180-howix091	217	15	cell	cell	NN
cord-000180-howix091	217	16	cycle	cycle	NN
cord-000180-howix091	217	17	in	in	IN
cord-000180-howix091	217	18	the	the	DT
cord-000180-howix091	217	19	absence	absence	NN
cord-000180-howix091	217	20	of	of	IN
cord-000180-howix091	217	21	serum	serum	NN
cord-000180-howix091	217	22	,	,	,
cord-000180-howix091	217	23	may	may	MD
cord-000180-howix091	217	24	be	be	VB
cord-000180-howix091	217	25	sufficient	sufficient	JJ
cord-000180-howix091	217	26	to	to	TO
cord-000180-howix091	217	27	induce	induce	VB
cord-000180-howix091	217	28	a	a	DT
cord-000180-howix091	217	29	stress	stress	NN
cord-000180-howix091	217	30	response	response	NN
cord-000180-howix091	217	31	and	and	CC
cord-000180-howix091	217	32	trigger	trigger	NN
cord-000180-howix091	217	33	apoptosis	apoptosis	NN
cord-000180-howix091	217	34	.	.	.
cord-000180-howix091	218	1	Both	both	DT
cord-000180-howix091	218	2	bcl2	bcl2	XX
cord-000180-howix091	218	3	(	(	-LRB-
cord-000180-howix091	218	4	Bcl-2	Bcl-2	NNP
cord-000180-howix091	218	5	)	)	-RRB-
cord-000180-howix091	218	6	and	and	CC
cord-000180-howix091	218	7	bcl2l1	bcl2l1	.
cord-000180-howix091	219	1	(	(	-LRB-
cord-000180-howix091	219	2	Bcl	Bcl	NNP
cord-000180-howix091	219	3	-	-	HYPH
cord-000180-howix091	219	4	xl	xl	NNP
cord-000180-howix091	219	5	)	)	-RRB-
cord-000180-howix091	219	6	belong	belong	VBP
cord-000180-howix091	219	7	to	to	IN
cord-000180-howix091	219	8	the	the	DT
cord-000180-howix091	219	9	Bcl-2	Bcl-2	NNP
cord-000180-howix091	219	10	family	family	NN
cord-000180-howix091	219	11	of	of	IN
cord-000180-howix091	219	12	apoptosis	apoptosis	NN
cord-000180-howix091	219	13	regulators	regulator	NNS
cord-000180-howix091	219	14	that	that	WDT
cord-000180-howix091	219	15	provide	provide	VBP
cord-000180-howix091	219	16	cellular	cellular	JJ
cord-000180-howix091	219	17	protection	protection	NN
cord-000180-howix091	219	18	from	from	IN
cord-000180-howix091	219	19	a	a	DT
cord-000180-howix091	219	20	range	range	NN
cord-000180-howix091	219	21	of	of	IN
cord-000180-howix091	219	22	harmful	harmful	JJ
cord-000180-howix091	219	23	stimuli	stimulus	NNS
cord-000180-howix091	219	24	such	such	JJ
cord-000180-howix091	219	25	as	as	IN
cord-000180-howix091	219	26	cytokine	cytokine	JJ
cord-000180-howix091	219	27	deprivation	deprivation	NN
cord-000180-howix091	219	28	,	,	,
cord-000180-howix091	219	29	UV	uv	NN
cord-000180-howix091	219	30	-	-	HYPH
cord-000180-howix091	219	31	and	and	CC
cord-000180-howix091	219	32	cirradiation	cirradiation	NN
cord-000180-howix091	219	33	[	[	-LRB-
cord-000180-howix091	219	34	37	37	CD
cord-000180-howix091	219	35	]	]	-RRB-
cord-000180-howix091	219	36	.	.	.
cord-000180-howix091	220	1	Bcl-2	Bcl-2	NNP
cord-000180-howix091	220	2	and	and	CC
cord-000180-howix091	220	3	Bcl	Bcl	NNP
cord-000180-howix091	220	4	-	-	HYPH
cord-000180-howix091	220	5	xl	xl	NNP
cord-000180-howix091	220	6	are	be	VBP
cord-000180-howix091	220	7	found	find	VBN
cord-000180-howix091	220	8	in	in	IN
cord-000180-howix091	220	9	the	the	DT
cord-000180-howix091	220	10	outer	outer	JJ
cord-000180-howix091	220	11	mitochondrial	mitochondrial	NN
cord-000180-howix091	220	12	membrane	membrane	NN
cord-000180-howix091	220	13	and	and	CC
cord-000180-howix091	220	14	are	be	VBP
cord-000180-howix091	220	15	thought	think	VBN
cord-000180-howix091	220	16	to	to	TO
cord-000180-howix091	220	17	suppress	suppress	VB
cord-000180-howix091	220	18	apoptosis	apoptosis	NN
cord-000180-howix091	220	19	by	by	IN
cord-000180-howix091	220	20	blocking	block	VBG
cord-000180-howix091	220	21	mitochondrial	mitochondrial	JJ
cord-000180-howix091	220	22	outer	outer	JJ
cord-000180-howix091	220	23	-	-	HYPH
cord-000180-howix091	220	24	membrane	membrane	NN
cord-000180-howix091	220	25	permeabilisation	permeabilisation	NN
cord-000180-howix091	220	26	through	through	IN
cord-000180-howix091	220	27	the	the	DT
cord-000180-howix091	220	28	sequestration	sequestration	NN
cord-000180-howix091	220	29	of	of	IN
cord-000180-howix091	220	30	pro	pro	JJ
cord-000180-howix091	220	31	-	-	JJ
cord-000180-howix091	220	32	apoptotic	apoptotic	JJ
cord-000180-howix091	220	33	Bcl2	Bcl2	NNP
cord-000180-howix091	220	34	family	family	NN
cord-000180-howix091	220	35	members	member	NNS
cord-000180-howix091	220	36	[	[	-LRB-
cord-000180-howix091	220	37	38	38	CD
cord-000180-howix091	220	38	]	]	-RRB-
cord-000180-howix091	220	39	.	.	.
cord-000180-howix091	221	1	Given	give	VBN
cord-000180-howix091	221	2	the	the	DT
cord-000180-howix091	221	3	up	up	JJ
cord-000180-howix091	221	4	-	-	HYPH
cord-000180-howix091	221	5	regulation	regulation	NN
cord-000180-howix091	221	6	of	of	IN
cord-000180-howix091	221	7	four	four	CD
cord-000180-howix091	221	8	anti	anti	JJ
cord-000180-howix091	221	9	-	-	JJ
cord-000180-howix091	221	10	apoptotic	apoptotic	JJ
cord-000180-howix091	221	11	genes	gene	NNS
cord-000180-howix091	221	12	,	,	,
cord-000180-howix091	221	13	birc2	birc2	NN
cord-000180-howix091	221	14	,	,	,
cord-000180-howix091	221	15	birc3	birc3	NN
cord-000180-howix091	221	16	,	,	,
cord-000180-howix091	221	17	bcl2	bcl2	NNP
cord-000180-howix091	221	18	and	and	CC
cord-000180-howix091	221	19	bcl2l1	bcl2l1	NN
cord-000180-howix091	221	20	,	,	,
cord-000180-howix091	221	21	through	through	IN
cord-000180-howix091	221	22	the	the	DT
cord-000180-howix091	221	23	activation	activation	NN
cord-000180-howix091	221	24	of	of	IN
cord-000180-howix091	221	25	multiple	multiple	JJ
cord-000180-howix091	221	26	signalling	signal	VBG
cord-000180-howix091	221	27	pathways	pathway	NNS
cord-000180-howix091	221	28	by	by	IN
cord-000180-howix091	221	29	entry	entry	NN
cord-000180-howix091	221	30	-	-	HYPH
cord-000180-howix091	221	31	defective	defective	JJ
cord-000180-howix091	221	32	HSV-1	hsv-1	NN
cord-000180-howix091	221	33	,	,	,
cord-000180-howix091	221	34	this	this	DT
cord-000180-howix091	221	35	establishes	establish	VBZ
cord-000180-howix091	221	36	a	a	DT
cord-000180-howix091	221	37	role	role	NN
cord-000180-howix091	221	38	for	for	IN
cord-000180-howix091	221	39	gD	gd	DT
cord-000180-howix091	221	40	binding	bind	VBG
cord-000180-howix091	221	41	in	in	IN
cord-000180-howix091	221	42	shifting	shift	VBG
cord-000180-howix091	221	43	the	the	DT
cord-000180-howix091	221	44	intracellular	intracellular	JJ
cord-000180-howix091	221	45	environment	environment	NN
cord-000180-howix091	221	46	towards	towards	IN
cord-000180-howix091	221	47	a	a	DT
cord-000180-howix091	221	48	more	more	RBR
cord-000180-howix091	221	49	anti	anti	JJ
cord-000180-howix091	221	50	-	-	JJ
cord-000180-howix091	221	51	apoptotic	apoptotic	JJ
cord-000180-howix091	221	52	stance	stance	NN
cord-000180-howix091	221	53	.	.	.
cord-000180-howix091	221	54	.	.	.
cord-000180-howix091	222	1	Model	model	NN
cord-000180-howix091	222	2	for	for	IN
cord-000180-howix091	222	3	glycoprotein	glycoprotein	NN
cord-000180-howix091	222	4	-	-	HYPH
cord-000180-howix091	222	5	receptor	receptor	NN
cord-000180-howix091	222	6	interactions	interaction	NNS
cord-000180-howix091	222	7	in	in	IN
cord-000180-howix091	222	8	the	the	DT
cord-000180-howix091	222	9	induction	induction	NN
cord-000180-howix091	222	10	of	of	IN
cord-000180-howix091	222	11	intracellular	intracellular	JJ
cord-000180-howix091	222	12	signalling	signal	VBG
cord-000180-howix091	222	13	pathways	pathway	NNS
cord-000180-howix091	222	14	by	by	IN
cord-000180-howix091	222	15	HSV-1	hsv-1	NN
cord-000180-howix091	222	16	.	.	.
cord-000180-howix091	223	1	Glycoprotein	glycoprotein	NN
cord-000180-howix091	223	2	D	d	NN
cord-000180-howix091	223	3	acts	act	VBZ
cord-000180-howix091	223	4	as	as	IN
cord-000180-howix091	223	5	the	the	DT
cord-000180-howix091	223	6	main	main	JJ
cord-000180-howix091	223	7	signalling	signalling	NN
cord-000180-howix091	223	8	molecule	molecule	NN
cord-000180-howix091	223	9	on	on	IN
cord-000180-howix091	223	10	the	the	DT
cord-000180-howix091	223	11	surface	surface	NN
cord-000180-howix091	223	12	of	of	IN
cord-000180-howix091	223	13	the	the	DT
cord-000180-howix091	223	14	HSV-1	HSV-1	NNP
cord-000180-howix091	223	15	envelope	envelope	NN
cord-000180-howix091	223	16	.	.	.
cord-000180-howix091	224	1	gH	gH	NNP
cord-000180-howix091	224	2	interacts	interact	VBZ
cord-000180-howix091	224	3	with	with	IN
cord-000180-howix091	224	4	a	a	DT
cord-000180-howix091	224	5	v	v	NN
cord-000180-howix091	224	6	b	b	NN
cord-000180-howix091	224	7	3	3	CD
cord-000180-howix091	224	8	integrins	integrin	NNS
cord-000180-howix091	224	9	to	to	TO
cord-000180-howix091	224	10	potentially	potentially	RB
cord-000180-howix091	224	11	trigger	trigger	VB
cord-000180-howix091	224	12	the	the	DT
cord-000180-howix091	224	13	production	production	NN
cord-000180-howix091	224	14	of	of	IN
cord-000180-howix091	224	15	IFN	IFN	NNP
cord-000180-howix091	224	16	-	-	HYPH
cord-000180-howix091	224	17	b	b	NNP
cord-000180-howix091	224	18	,	,	,
cord-000180-howix091	224	19	which	which	WDT
cord-000180-howix091	224	20	is	be	VBZ
cord-000180-howix091	224	21	known	know	VBN
cord-000180-howix091	224	22	to	to	TO
cord-000180-howix091	224	23	involve	involve	VB
cord-000180-howix091	224	24	IRF-3	IRF-3	NNP
cord-000180-howix091	224	25	and	and	CC
cord-000180-howix091	224	26	7	7	CD
cord-000180-howix091	224	27	[	[	-LRB-
cord-000180-howix091	224	28	48	48	CD
cord-000180-howix091	224	29	]	]	-RRB-
cord-000180-howix091	224	30	.	.	.
cord-000180-howix091	225	1	Binding	bind	VBG
cord-000180-howix091	225	2	by	by	IN
cord-000180-howix091	225	3	gD	gD	NNP
cord-000180-howix091	225	4	to	to	IN
cord-000180-howix091	225	5	HvEM	HvEM	NNP
cord-000180-howix091	225	6	may	may	MD
cord-000180-howix091	225	7	lead	lead	VB
cord-000180-howix091	225	8	to	to	IN
cord-000180-howix091	225	9	the	the	DT
cord-000180-howix091	225	10	activation	activation	NN
cord-000180-howix091	225	11	of	of	IN
cord-000180-howix091	225	12	TRAF	TRAF	NNP
cord-000180-howix091	225	13	molecules	molecule	NNS
cord-000180-howix091	225	14	,	,	,
cord-000180-howix091	225	15	which	which	WDT
cord-000180-howix091	225	16	in	in	IN
cord-000180-howix091	225	17	turn	turn	NN
cord-000180-howix091	225	18	stimulate	stimulate	VBP
cord-000180-howix091	225	19	the	the	DT
cord-000180-howix091	225	20	NF	NF	NNP
cord-000180-howix091	225	21	-	-	HYPH
cord-000180-howix091	225	22	kB	kB	NNP
cord-000180-howix091	225	23	signaling	signal	VBG
cord-000180-howix091	225	24	cascade	cascade	NN
cord-000180-howix091	225	25	.	.	.
cord-000180-howix091	226	1	This	this	DT
cord-000180-howix091	226	2	pathway	pathway	NN
cord-000180-howix091	226	3	up	up	RB
cord-000180-howix091	226	4	-	-	HYPH
cord-000180-howix091	226	5	regulates	regulate	VBZ
cord-000180-howix091	226	6	a	a	DT
cord-000180-howix091	226	7	number	number	NN
cord-000180-howix091	226	8	of	of	IN
cord-000180-howix091	226	9	cellular	cellular	JJ
cord-000180-howix091	226	10	genes	gene	NNS
cord-000180-howix091	226	11	in	in	IN
cord-000180-howix091	226	12	addition	addition	NN
cord-000180-howix091	226	13	to	to	IN
cord-000180-howix091	226	14	augmenting	augment	VBG
cord-000180-howix091	226	15	early	early	JJ
cord-000180-howix091	226	16	viral	viral	JJ
cord-000180-howix091	226	17	gene	gene	NN
cord-000180-howix091	226	18	expression	expression	NN
cord-000180-howix091	226	19	.	.	.
cord-000180-howix091	227	1	NF	NF	NNP
cord-000180-howix091	227	2	-	-	HYPH
cord-000180-howix091	227	3	kBresponsive	kBresponsive	NNP
cord-000180-howix091	227	4	genes	gene	NNS
cord-000180-howix091	227	5	,	,	,
cord-000180-howix091	227	6	birc2	birc2	NN
cord-000180-howix091	227	7	and	and	CC
cord-000180-howix091	227	8	birc3	birc3	NN
cord-000180-howix091	227	9	,	,	,
cord-000180-howix091	227	10	have	have	VBP
cord-000180-howix091	227	11	an	an	DT
cord-000180-howix091	227	12	anti	anti	JJ
cord-000180-howix091	227	13	-	-	JJ
cord-000180-howix091	227	14	apoptotic	apoptotic	JJ
cord-000180-howix091	227	15	role	role	NN
cord-000180-howix091	227	16	,	,	,
cord-000180-howix091	227	17	but	but	CC
cord-000180-howix091	227	18	paradoxically	paradoxically	RB
cord-000180-howix091	227	19	,	,	,
cord-000180-howix091	227	20	inflammatory	inflammatory	JJ
cord-000180-howix091	227	21	mediators	mediator	NNS
cord-000180-howix091	227	22	such	such	JJ
cord-000180-howix091	227	23	as	as	IN
cord-000180-howix091	227	24	ccl2	ccl2	NNS
cord-000180-howix091	227	25	are	be	VBP
cord-000180-howix091	227	26	also	also	RB
cord-000180-howix091	227	27	up	up	RB
cord-000180-howix091	227	28	-	-	HYPH
cord-000180-howix091	227	29	regulated	regulate	VBN
cord-000180-howix091	227	30	.	.	.
cord-000180-howix091	228	1	gDinduced	gdinduced	JJ
cord-000180-howix091	228	2	signalling	signalling	NN
cord-000180-howix091	228	3	of	of	IN
cord-000180-howix091	228	4	the	the	DT
cord-000180-howix091	228	5	Jak	Jak	NNP
cord-000180-howix091	228	6	/	/	SYM
cord-000180-howix091	228	7	Stat	Stat	NNP
cord-000180-howix091	228	8	and	and	CC
cord-000180-howix091	228	9	Jak	Jak	NNP
cord-000180-howix091	228	10	/	/	SYM
cord-000180-howix091	228	11	Src	Src	NNP
cord-000180-howix091	228	12	pathways	pathway	NNS
cord-000180-howix091	228	13	also	also	RB
cord-000180-howix091	228	14	results	result	VBZ
cord-000180-howix091	228	15	in	in	IN
cord-000180-howix091	228	16	the	the	DT
cord-000180-howix091	228	17	differential	differential	JJ
cord-000180-howix091	228	18	expression	expression	NN
cord-000180-howix091	228	19	of	of	IN
cord-000180-howix091	228	20	genes	gene	NNS
cord-000180-howix091	228	21	associated	associate	VBN
cord-000180-howix091	228	22	with	with	IN
cord-000180-howix091	228	23	anti	anti	JJ
cord-000180-howix091	228	24	-	-	JJ
cord-000180-howix091	228	25	apoptosis	apoptosis	JJ
cord-000180-howix091	228	26	and	and	CC
cord-000180-howix091	228	27	inflammation	inflammation	NN
cord-000180-howix091	228	28	.	.	.
cord-000180-howix091	229	1	The	the	DT
cord-000180-howix091	229	2	up	up	JJ
cord-000180-howix091	229	3	-	-	HYPH
cord-000180-howix091	229	4	regulation	regulation	NN
cord-000180-howix091	229	5	of	of	IN
cord-000180-howix091	229	6	c	c	NN
cord-000180-howix091	229	7	-	-	:
cord-000180-howix091	229	8	Myc	Myc	NNP
cord-000180-howix091	229	9	could	could	MD
cord-000180-howix091	229	10	lead	lead	VB
cord-000180-howix091	229	11	to	to	IN
cord-000180-howix091	229	12	a	a	DT
cord-000180-howix091	229	13	corresponding	corresponding	JJ
cord-000180-howix091	229	14	increase	increase	NN
cord-000180-howix091	229	15	in	in	IN
cord-000180-howix091	229	16	cdk2	cdk2	NNP
cord-000180-howix091	229	17	,	,	,
cord-000180-howix091	229	18	which	which	WDT
cord-000180-howix091	229	19	has	have	VBZ
cord-000180-howix091	229	20	a	a	DT
cord-000180-howix091	229	21	role	role	NN
cord-000180-howix091	229	22	in	in	IN
cord-000180-howix091	229	23	promoting	promote	VBG
cord-000180-howix091	229	24	DNA	dna	NN
cord-000180-howix091	229	25	replication	replication	NN
cord-000180-howix091	229	26	and	and	CC
cord-000180-howix091	229	27	gene	gene	NN
cord-000180-howix091	229	28	transcription	transcription	NN
cord-000180-howix091	229	29	during	during	IN
cord-000180-howix091	229	30	infection	infection	NN
cord-000180-howix091	229	31	.	.	.
cord-000180-howix091	230	1	It	-PRON-	PRP
cord-000180-howix091	230	2	should	should	MD
cord-000180-howix091	230	3	be	be	VB
cord-000180-howix091	230	4	noted	note	VBN
cord-000180-howix091	230	5	that	that	IN
cord-000180-howix091	230	6	most	most	JJS
cord-000180-howix091	230	7	signalling	signal	VBG
cord-000180-howix091	230	8	cascades	cascade	NNS
cord-000180-howix091	230	9	have	have	VBP
cord-000180-howix091	230	10	been	be	VBN
cord-000180-howix091	230	11	elucidated	elucidate	VBN
cord-000180-howix091	230	12	in	in	IN
cord-000180-howix091	230	13	non	non	JJ
cord-000180-howix091	230	14	-	-	JJ
cord-000180-howix091	230	15	fibroblast	fibroblast	JJ
cord-000180-howix091	230	16	cells	cell	NNS
cord-000180-howix091	230	17	lines	line	NNS
cord-000180-howix091	230	18	,	,	,
cord-000180-howix091	230	19	so	so	IN
cord-000180-howix091	230	20	the	the	DT
cord-000180-howix091	230	21	role	role	NN
cord-000180-howix091	230	22	of	of	IN
cord-000180-howix091	230	23	specific	specific	JJ
cord-000180-howix091	230	24	kinases	kinase	NNS
cord-000180-howix091	230	25	may	may	MD
cord-000180-howix091	230	26	vary	vary	VB
cord-000180-howix091	230	27	in	in	IN
cord-000180-howix091	230	28	HFFs	hff	NNS
cord-000180-howix091	230	29	.	.	.
cord-000180-howix091	231	1	doi:10.1371	doi:10.1371	NNP
cord-000180-howix091	232	1	/journal.pone.0009560.g003	/journal.pone.0009560.g003	.
cord-000180-howix091	233	1	It	-PRON-	PRP
cord-000180-howix091	233	2	is	be	VBZ
cord-000180-howix091	233	3	less	less	RBR
cord-000180-howix091	233	4	apparent	apparent	JJ
cord-000180-howix091	233	5	as	as	IN
cord-000180-howix091	233	6	to	to	IN
cord-000180-howix091	233	7	the	the	DT
cord-000180-howix091	233	8	biological	biological	JJ
cord-000180-howix091	233	9	relevance	relevance	NN
cord-000180-howix091	233	10	of	of	IN
cord-000180-howix091	233	11	an	an	DT
cord-000180-howix091	233	12	innate	innate	JJ
cord-000180-howix091	233	13	immune	immune	JJ
cord-000180-howix091	233	14	response	response	NN
cord-000180-howix091	233	15	stimulated	stimulate	VBN
cord-000180-howix091	233	16	through	through	IN
cord-000180-howix091	233	17	HSV-1	hsv-1	NN
cord-000180-howix091	233	18	binding	bind	VBG
cord-000180-howix091	233	19	.	.	.
cord-000180-howix091	234	1	It	-PRON-	PRP
cord-000180-howix091	234	2	may	may	MD
cord-000180-howix091	234	3	be	be	VB
cord-000180-howix091	234	4	that	that	IN
cord-000180-howix091	234	5	there	there	EX
cord-000180-howix091	234	6	is	be	VBZ
cord-000180-howix091	234	7	a	a	DT
cord-000180-howix091	234	8	'	'	``
cord-000180-howix091	234	9	'	'	``
cord-000180-howix091	234	10	cost	cost	NN
cord-000180-howix091	234	11	'	'	''
cord-000180-howix091	234	12	'	'	''
cord-000180-howix091	234	13	associated	associate	VBN
cord-000180-howix091	234	14	with	with	IN
cord-000180-howix091	234	15	altering	alter	VBG
cord-000180-howix091	234	16	the	the	DT
cord-000180-howix091	234	17	intracellular	intracellular	JJ
cord-000180-howix091	234	18	environment	environment	NN
cord-000180-howix091	234	19	,	,	,
cord-000180-howix091	234	20	which	which	WDT
cord-000180-howix091	234	21	leads	lead	VBZ
cord-000180-howix091	234	22	to	to	IN
cord-000180-howix091	234	23	the	the	DT
cord-000180-howix091	234	24	differential	differential	JJ
cord-000180-howix091	234	25	expression	expression	NN
cord-000180-howix091	234	26	of	of	IN
cord-000180-howix091	234	27	cytokines	cytokine	NNS
cord-000180-howix091	234	28	,	,	,
cord-000180-howix091	234	29	such	such	JJ
cord-000180-howix091	234	30	as	as	IN
cord-000180-howix091	234	31	ccl2	ccl2	NN
cord-000180-howix091	234	32	,	,	,
cord-000180-howix091	234	33	that	that	WDT
cord-000180-howix091	234	34	are	be	VBP
cord-000180-howix091	234	35	under	under	IN
cord-000180-howix091	234	36	similar	similar	JJ
cord-000180-howix091	234	37	transcriptional	transcriptional	JJ
cord-000180-howix091	234	38	regulation	regulation	NN
cord-000180-howix091	234	39	as	as	IN
cord-000180-howix091	234	40	those	those	DT
cord-000180-howix091	234	41	host	host	NN
cord-000180-howix091	234	42	factors	factor	NNS
cord-000180-howix091	234	43	that	that	WDT
cord-000180-howix091	234	44	are	be	VBP
cord-000180-howix091	234	45	favourable	favourable	JJ
cord-000180-howix091	234	46	for	for	IN
cord-000180-howix091	234	47	virus	virus	NN
cord-000180-howix091	234	48	replication	replication	NN
cord-000180-howix091	234	49	.	.	.
cord-000180-howix091	235	1	Signalling	signal	VBG
cord-000180-howix091	235	2	by	by	IN
cord-000180-howix091	235	3	secreted	secrete	VBN
cord-000180-howix091	235	4	Type	type	NN
cord-000180-howix091	235	5	I	I	NNP
cord-000180-howix091	235	6	IFNs	ifns	NN
cord-000180-howix091	235	7	occurs	occur	VBZ
cord-000180-howix091	235	8	through	through	IN
cord-000180-howix091	235	9	the	the	DT
cord-000180-howix091	235	10	Jak	Jak	NNP
cord-000180-howix091	235	11	/	/	SYM
cord-000180-howix091	235	12	Stat	Stat	NNP
cord-000180-howix091	235	13	pathway	pathway	NN
cord-000180-howix091	235	14	results	result	NNS
cord-000180-howix091	235	15	in	in	IN
cord-000180-howix091	235	16	the	the	DT
cord-000180-howix091	235	17	expression	expression	NN
cord-000180-howix091	235	18	of	of	IN
cord-000180-howix091	235	19	various	various	JJ
cord-000180-howix091	235	20	ISGs	isg	NNS
cord-000180-howix091	235	21	;	;	:
cord-000180-howix091	235	22	a	a	DT
cord-000180-howix091	235	23	response	response	NN
cord-000180-howix091	235	24	that	that	WDT
cord-000180-howix091	235	25	is	be	VBZ
cord-000180-howix091	235	26	also	also	RB
cord-000180-howix091	235	27	triggered	trigger	VBN
cord-000180-howix091	235	28	by	by	IN
cord-000180-howix091	235	29	virus	virus	NN
cord-000180-howix091	235	30	entry	entry	NN
cord-000180-howix091	235	31	[	[	-LRB-
cord-000180-howix091	235	32	39	39	CD
cord-000180-howix091	235	33	]	]	-RRB-
cord-000180-howix091	235	34	.	.	.
cord-000180-howix091	236	1	Nevertheless	nevertheless	RB
cord-000180-howix091	236	2	,	,	,
cord-000180-howix091	236	3	productive	productive	JJ
cord-000180-howix091	236	4	infection	infection	NN
cord-000180-howix091	236	5	with	with	IN
cord-000180-howix091	236	6	HSV-1	hsv-1	NN
cord-000180-howix091	236	7	can	can	MD
cord-000180-howix091	236	8	down	down	RB
cord-000180-howix091	236	9	-	-	HYPH
cord-000180-howix091	236	10	regulate	regulate	VB
cord-000180-howix091	236	11	the	the	DT
cord-000180-howix091	236	12	triggered	trigger	VBN
cord-000180-howix091	236	13	ISG	ISG	NNP
cord-000180-howix091	236	14	response	response	NN
cord-000180-howix091	236	15	,	,	,
cord-000180-howix091	236	16	allowing	allow	VBG
cord-000180-howix091	236	17	viral	viral	JJ
cord-000180-howix091	236	18	replication	replication	NN
cord-000180-howix091	236	19	to	to	TO
cord-000180-howix091	236	20	continue	continue	VB
cord-000180-howix091	236	21	unhindered	unhindered	JJ
cord-000180-howix091	236	22	[	[	-LRB-
cord-000180-howix091	236	23	40	40	CD
cord-000180-howix091	236	24	]	]	-RRB-
cord-000180-howix091	236	25	.	.	.
cord-000180-howix091	237	1	Despite	despite	IN
cord-000180-howix091	237	2	our	-PRON-	PRP$
cord-000180-howix091	237	3	evidence	evidence	NN
cord-000180-howix091	237	4	that	that	IN
cord-000180-howix091	237	5	gD	gd	DT
cord-000180-howix091	237	6	binding	bind	VBG
cord-000180-howix091	237	7	by	by	IN
cord-000180-howix091	237	8	entry	entry	NN
cord-000180-howix091	237	9	-	-	HYPH
cord-000180-howix091	237	10	defective	defective	JJ
cord-000180-howix091	237	11	virions	virion	NNS
cord-000180-howix091	237	12	can	can	MD
cord-000180-howix091	237	13	induce	induce	VB
cord-000180-howix091	237	14	IFN	IFN	NNP
cord-000180-howix091	237	15	-	-	:
cord-000180-howix091	237	16	a	a	DT
cord-000180-howix091	237	17	mRNA	mRNA	NNP
cord-000180-howix091	237	18	expression	expression	NN
cord-000180-howix091	237	19	,	,	,
cord-000180-howix091	237	20	independent	independent	JJ
cord-000180-howix091	237	21	of	of	IN
cord-000180-howix091	237	22	gD	gd	DT
cord-000180-howix091	237	23	glycosylation	glycosylation	NN
cord-000180-howix091	237	24	status	status	NN
cord-000180-howix091	237	25	,	,	,
cord-000180-howix091	237	26	these	these	DT
cord-000180-howix091	237	27	data	datum	NNS
cord-000180-howix091	237	28	also	also	RB
cord-000180-howix091	237	29	fit	fit	VBP
cord-000180-howix091	237	30	with	with	IN
cord-000180-howix091	237	31	published	publish	VBN
cord-000180-howix091	237	32	observations	observation	NNS
cord-000180-howix091	237	33	that	that	IN
cord-000180-howix091	237	34	binding	bind	VBG
cord-000180-howix091	237	35	by	by	IN
cord-000180-howix091	237	36	HSV-1	hsv-1	NN
cord-000180-howix091	237	37	is	be	VBZ
cord-000180-howix091	237	38	insufficient	insufficient	JJ
cord-000180-howix091	237	39	to	to	TO
cord-000180-howix091	237	40	cause	cause	VB
cord-000180-howix091	237	41	the	the	DT
cord-000180-howix091	237	42	up	up	JJ
cord-000180-howix091	237	43	-	-	HYPH
cord-000180-howix091	237	44	regulation	regulation	NN
cord-000180-howix091	237	45	of	of	IN
cord-000180-howix091	237	46	interferon	interferon	NN
cord-000180-howix091	237	47	-	-	HYPH
cord-000180-howix091	237	48	stimulated	stimulate	VBN
cord-000180-howix091	237	49	genes	gene	NNS
cord-000180-howix091	237	50	[	[	-LRB-
cord-000180-howix091	237	51	30	30	CD
cord-000180-howix091	237	52	]	]	-RRB-
cord-000180-howix091	237	53	.	.	.
cord-000180-howix091	238	1	The	the	DT
cord-000180-howix091	238	2	up	up	JJ
cord-000180-howix091	238	3	-	-	HYPH
cord-000180-howix091	238	4	regulation	regulation	NN
cord-000180-howix091	238	5	of	of	IN
cord-000180-howix091	238	6	IFN	IFN	NNP
cord-000180-howix091	238	7	-	-	HYPH
cord-000180-howix091	238	8	b	b	NNP
cord-000180-howix091	238	9	,	,	,
cord-000180-howix091	238	10	albeit	albeit	IN
cord-000180-howix091	238	11	it	-PRON-	PRP
cord-000180-howix091	238	12	through	through	IN
cord-000180-howix091	238	13	a	a	DT
cord-000180-howix091	238	14	different	different	JJ
cord-000180-howix091	238	15	mechanism	mechanism	NN
cord-000180-howix091	238	16	,	,	,
cord-000180-howix091	238	17	is	be	VBZ
cord-000180-howix091	238	18	suggestive	suggestive	JJ
cord-000180-howix091	238	19	of	of	IN
cord-000180-howix091	238	20	a	a	DT
cord-000180-howix091	238	21	previously	previously	RB
cord-000180-howix091	238	22	unidentified	unidentified	JJ
cord-000180-howix091	238	23	role	role	NN
cord-000180-howix091	238	24	for	for	IN
cord-000180-howix091	238	25	gH	gh	NN
cord-000180-howix091	238	26	in	in	IN
cord-000180-howix091	238	27	eliciting	elicit	VBG
cord-000180-howix091	238	28	a	a	DT
cord-000180-howix091	238	29	change	change	NN
cord-000180-howix091	238	30	in	in	IN
cord-000180-howix091	238	31	host	host	NN
cord-000180-howix091	238	32	gene	gene	NN
cord-000180-howix091	238	33	expression	expression	NN
cord-000180-howix091	238	34	.	.	.
cord-000180-howix091	239	1	An	an	DT
cord-000180-howix091	239	2	entry	entry	NN
cord-000180-howix091	239	3	-	-	HYPH
cord-000180-howix091	239	4	defective	defective	JJ
cord-000180-howix091	239	5	HSV-1	HSV-1	NNP
cord-000180-howix091	239	6	mutant	mutant	JJ
cord-000180-howix091	239	7	lacking	lack	VBG
cord-000180-howix091	239	8	gB	gB	NNP
cord-000180-howix091	240	1	that	that	DT
cord-000180-howix091	240	2	also	also	RB
cord-000180-howix091	240	3	contains	contain	VBZ
cord-000180-howix091	240	4	an	an	DT
cord-000180-howix091	240	5	RGE	rge	NN
cord-000180-howix091	240	6	rather	rather	RB
cord-000180-howix091	240	7	than	than	IN
cord-000180-howix091	240	8	the	the	DT
cord-000180-howix091	240	9	integrin	integrin	NN
cord-000180-howix091	240	10	binding	bind	VBG
cord-000180-howix091	240	11	RGD	RGD	NNP
cord-000180-howix091	240	12	motif	motif	NN
cord-000180-howix091	240	13	of	of	IN
cord-000180-howix091	240	14	gH	gH	NNP
cord-000180-howix091	240	15	has	have	VBZ
cord-000180-howix091	240	16	been	be	VBN
cord-000180-howix091	240	17	constructed	construct	VBN
cord-000180-howix091	240	18	and	and	CC
cord-000180-howix091	240	19	future	future	JJ
cord-000180-howix091	240	20	studies	study	NNS
cord-000180-howix091	240	21	may	may	MD
cord-000180-howix091	240	22	further	further	RB
cord-000180-howix091	240	23	elicit	elicit	VB
cord-000180-howix091	240	24	the	the	DT
cord-000180-howix091	240	25	role	role	NN
cord-000180-howix091	240	26	of	of	IN
cord-000180-howix091	240	27	gH	gh	NN
cord-000180-howix091	240	28	in	in	IN
cord-000180-howix091	240	29	interferon	interferon	JJ
cord-000180-howix091	240	30	stimulation	stimulation	NN
cord-000180-howix091	240	31	.	.	.
cord-000180-howix091	241	1	The	the	DT
cord-000180-howix091	241	2	methodology	methodology	NN
cord-000180-howix091	241	3	used	use	VBN
cord-000180-howix091	241	4	here	here	RB
cord-000180-howix091	241	5	required	require	VBD
cord-000180-howix091	241	6	the	the	DT
cord-000180-howix091	241	7	serum	serum	NN
cord-000180-howix091	241	8	-	-	HYPH
cord-000180-howix091	241	9	starvation	starvation	NN
cord-000180-howix091	241	10	of	of	IN
cord-000180-howix091	241	11	primary	primary	JJ
cord-000180-howix091	241	12	human	human	JJ
cord-000180-howix091	241	13	fibroblasts	fibroblast	NNS
cord-000180-howix091	241	14	for	for	IN
cord-000180-howix091	241	15	five	five	CD
cord-000180-howix091	241	16	days	day	NNS
cord-000180-howix091	241	17	.	.	.
cord-000180-howix091	242	1	In	in	IN
cord-000180-howix091	242	2	the	the	DT
cord-000180-howix091	242	3	absence	absence	NN
cord-000180-howix091	242	4	of	of	IN
cord-000180-howix091	242	5	serum	serum	NN
cord-000180-howix091	242	6	,	,	,
cord-000180-howix091	242	7	primary	primary	JJ
cord-000180-howix091	242	8	fibroblasts	fibroblast	NNS
cord-000180-howix091	242	9	rapidly	rapidly	RB
cord-000180-howix091	242	10	enter	enter	VBP
cord-000180-howix091	242	11	a	a	DT
cord-000180-howix091	242	12	quiescent	quiescent	JJ
cord-000180-howix091	242	13	state	state	NN
cord-000180-howix091	242	14	.	.	.
cord-000180-howix091	243	1	As	as	IN
cord-000180-howix091	243	2	a	a	DT
cord-000180-howix091	243	3	DNA	dna	NN
cord-000180-howix091	243	4	virus	virus	NN
cord-000180-howix091	243	5	that	that	WDT
cord-000180-howix091	243	6	requires	require	VBZ
cord-000180-howix091	243	7	host	host	NN
cord-000180-howix091	243	8	nuclear	nuclear	JJ
cord-000180-howix091	243	9	factors	factor	NNS
cord-000180-howix091	243	10	to	to	TO
cord-000180-howix091	243	11	replicate	replicate	VB
cord-000180-howix091	243	12	its	-PRON-	PRP$
cord-000180-howix091	243	13	genome	genome	NN
cord-000180-howix091	243	14	,	,	,
cord-000180-howix091	243	15	it	-PRON-	PRP
cord-000180-howix091	243	16	is	be	VBZ
cord-000180-howix091	243	17	therefore	therefore	RB
cord-000180-howix091	243	18	not	not	RB
cord-000180-howix091	243	19	surprising	surprising	JJ
cord-000180-howix091	243	20	that	that	IN
cord-000180-howix091	243	21	HSV-1	HSV-1	NNP
cord-000180-howix091	243	22	would	would	MD
cord-000180-howix091	243	23	stimulate	stimulate	VB
cord-000180-howix091	243	24	cells	cell	NNS
cord-000180-howix091	243	25	from	from	IN
cord-000180-howix091	243	26	a	a	DT
cord-000180-howix091	243	27	G0	g0	NN
cord-000180-howix091	243	28	state	state	NN
cord-000180-howix091	243	29	into	into	IN
cord-000180-howix091	243	30	one	one	CD
cord-000180-howix091	243	31	that	that	WDT
cord-000180-howix091	243	32	would	would	MD
cord-000180-howix091	243	33	favour	favour	VB
cord-000180-howix091	243	34	DNA	dna	NN
cord-000180-howix091	243	35	replication	replication	NN
cord-000180-howix091	243	36	and	and	CC
cord-000180-howix091	243	37	possibly	possibly	RB
cord-000180-howix091	243	38	promote	promote	VB
cord-000180-howix091	243	39	the	the	DT
cord-000180-howix091	243	40	transcription	transcription	NN
cord-000180-howix091	243	41	of	of	IN
cord-000180-howix091	243	42	viral	viral	JJ
cord-000180-howix091	243	43	genes	gene	NNS
cord-000180-howix091	243	44	.	.	.
cord-000180-howix091	244	1	Quiescent	quiescent	JJ
cord-000180-howix091	244	2	cells	cell	NNS
cord-000180-howix091	244	3	in	in	IN
cord-000180-howix091	244	4	vitro	vitro	FW
cord-000180-howix091	244	5	have	have	VBP
cord-000180-howix091	244	6	very	very	RB
cord-000180-howix091	244	7	low	low	JJ
cord-000180-howix091	244	8	levels	level	NNS
cord-000180-howix091	244	9	expression	expression	NN
cord-000180-howix091	244	10	of	of	IN
cord-000180-howix091	244	11	the	the	DT
cord-000180-howix091	244	12	transcription	transcription	NN
cord-000180-howix091	244	13	factor	factor	NN
cord-000180-howix091	244	14	c	c	NNP
cord-000180-howix091	244	15	-	-	:
cord-000180-howix091	244	16	Myc	Myc	NNP
cord-000180-howix091	244	17	.	.	.
cord-000180-howix091	245	1	Its	-PRON-	PRP$
cord-000180-howix091	245	2	up	up	JJ
cord-000180-howix091	245	3	-	-	HYPH
cord-000180-howix091	245	4	regulation	regulation	NN
cord-000180-howix091	245	5	is	be	VBZ
cord-000180-howix091	245	6	rapidly	rapidly	RB
cord-000180-howix091	245	7	induced	induce	VBN
cord-000180-howix091	245	8	after	after	IN
cord-000180-howix091	245	9	mitogenic	mitogenic	JJ
cord-000180-howix091	245	10	stimulation	stimulation	NN
cord-000180-howix091	245	11	or	or	CC
cord-000180-howix091	245	12	the	the	DT
cord-000180-howix091	245	13	introduction	introduction	NN
cord-000180-howix091	245	14	of	of	IN
cord-000180-howix091	245	15	serum	serum	NN
cord-000180-howix091	245	16	and	and	CC
cord-000180-howix091	245	17	increased	increase	VBN
cord-000180-howix091	245	18	expression	expression	NN
cord-000180-howix091	245	19	of	of	IN
cord-000180-howix091	245	20	c	c	NN
cord-000180-howix091	245	21	-	-	:
cord-000180-howix091	245	22	Myc	Myc	NNP
cord-000180-howix091	245	23	is	be	VBZ
cord-000180-howix091	245	24	consistent	consistent	JJ
cord-000180-howix091	245	25	with	with	IN
cord-000180-howix091	245	26	the	the	DT
cord-000180-howix091	245	27	advancement	advancement	NN
cord-000180-howix091	245	28	of	of	IN
cord-000180-howix091	245	29	cellular	cellular	JJ
cord-000180-howix091	245	30	proliferation	proliferation	NN
cord-000180-howix091	245	31	[	[	-LRB-
cord-000180-howix091	245	32	41	41	CD
cord-000180-howix091	245	33	]	]	-RRB-
cord-000180-howix091	245	34	.	.	.
cord-000180-howix091	246	1	Control	Control	NNP
cord-000180-howix091	246	2	of	of	IN
cord-000180-howix091	246	3	myc	myc	NNP
cord-000180-howix091	246	4	transcription	transcription	NN
cord-000180-howix091	246	5	can	can	MD
cord-000180-howix091	246	6	be	be	VB
cord-000180-howix091	246	7	influenced	influence	VBN
cord-000180-howix091	246	8	by	by	IN
cord-000180-howix091	246	9	a	a	DT
cord-000180-howix091	246	10	number	number	NN
cord-000180-howix091	246	11	of	of	IN
cord-000180-howix091	246	12	pathways	pathway	NNS
cord-000180-howix091	246	13	,	,	,
cord-000180-howix091	246	14	including	include	VBG
cord-000180-howix091	246	15	PI3K	PI3K	NNP
cord-000180-howix091	246	16	/	/	SYM
cord-000180-howix091	246	17	Akt	Akt	NNP
cord-000180-howix091	246	18	signalling	signalling	NN
cord-000180-howix091	246	19	,	,	,
cord-000180-howix091	246	20	which	which	WDT
cord-000180-howix091	246	21	was	be	VBD
cord-000180-howix091	246	22	shown	show	VBN
cord-000180-howix091	246	23	here	here	RB
cord-000180-howix091	246	24	to	to	TO
cord-000180-howix091	246	25	occur	occur	VB
cord-000180-howix091	246	26	as	as	IN
cord-000180-howix091	246	27	a	a	DT
cord-000180-howix091	246	28	result	result	NN
cord-000180-howix091	246	29	of	of	IN
cord-000180-howix091	246	30	binding	bind	VBG
cord-000180-howix091	246	31	by	by	IN
cord-000180-howix091	246	32	gD.	gD.	NNS
cord-000180-howix091	246	33	A	a	DT
cord-000180-howix091	246	34	central	central	JJ
cord-000180-howix091	246	35	role	role	NN
cord-000180-howix091	246	36	for	for	IN
cord-000180-howix091	246	37	c	c	NNP
cord-000180-howix091	246	38	-	-	:
cord-000180-howix091	246	39	Myc	Myc	NNP
cord-000180-howix091	246	40	in	in	IN
cord-000180-howix091	246	41	promoting	promote	VBG
cord-000180-howix091	246	42	cell	cell	NN
cord-000180-howix091	246	43	-	-	HYPH
cord-000180-howix091	246	44	cycle	cycle	NN
cord-000180-howix091	246	45	progression	progression	NN
cord-000180-howix091	246	46	is	be	VBZ
cord-000180-howix091	246	47	evident	evident	JJ
cord-000180-howix091	246	48	from	from	IN
cord-000180-howix091	246	49	the	the	DT
cord-000180-howix091	246	50	genes	gene	NNS
cord-000180-howix091	246	51	that	that	WDT
cord-000180-howix091	246	52	it	-PRON-	PRP
cord-000180-howix091	246	53	can	can	MD
cord-000180-howix091	246	54	up	up	RB
cord-000180-howix091	246	55	-	-	HYPH
cord-000180-howix091	246	56	regulate	regulate	VB
cord-000180-howix091	246	57	such	such	JJ
cord-000180-howix091	246	58	as	as	IN
cord-000180-howix091	246	59	eIF2	eIF2	NNP
cord-000180-howix091	246	60	[	[	-LRB-
cord-000180-howix091	246	61	42	42	CD
cord-000180-howix091	246	62	]	]	-RRB-
cord-000180-howix091	246	63	.	.	.
cord-000180-howix091	247	1	Progression	progression	NN
cord-000180-howix091	247	2	of	of	IN
cord-000180-howix091	247	3	the	the	DT
cord-000180-howix091	247	4	cell	cell	NN
cord-000180-howix091	247	5	cycle	cycle	NN
cord-000180-howix091	247	6	depends	depend	VBZ
cord-000180-howix091	247	7	on	on	IN
cord-000180-howix091	247	8	the	the	DT
cord-000180-howix091	247	9	additional	additional	JJ
cord-000180-howix091	247	10	activity	activity	NN
cord-000180-howix091	247	11	of	of	IN
cord-000180-howix091	247	12	cyclin	cyclin	NN
cord-000180-howix091	247	13	-	-	HYPH
cord-000180-howix091	247	14	dependent	dependent	JJ
cord-000180-howix091	247	15	kinases	kinase	NNS
cord-000180-howix091	247	16	.	.	.
cord-000180-howix091	248	1	By	by	IN
cord-000180-howix091	248	2	interacting	interact	VBG
cord-000180-howix091	248	3	with	with	IN
cord-000180-howix091	248	4	the	the	DT
cord-000180-howix091	248	5	promoters	promoter	NNS
cord-000180-howix091	248	6	for	for	IN
cord-000180-howix091	248	7	genes	gene	NNS
cord-000180-howix091	248	8	encoding	encode	VBG
cord-000180-howix091	248	9	cyclins	cyclin	NNS
cord-000180-howix091	248	10	and	and	CC
cord-000180-howix091	248	11	cyclin	cyclin	NN
cord-000180-howix091	248	12	-	-	HYPH
cord-000180-howix091	248	13	dependent	dependent	JJ
cord-000180-howix091	248	14	kinases	kinase	NNS
cord-000180-howix091	248	15	,	,	,
cord-000180-howix091	248	16	c	c	NN
cord-000180-howix091	248	17	-	-	:
cord-000180-howix091	248	18	Myc	Myc	NNP
cord-000180-howix091	248	19	can	can	MD
cord-000180-howix091	248	20	influence	influence	VB
cord-000180-howix091	248	21	the	the	DT
cord-000180-howix091	248	22	advancement	advancement	NN
cord-000180-howix091	248	23	on	on	IN
cord-000180-howix091	248	24	the	the	DT
cord-000180-howix091	248	25	cell	cell	NN
cord-000180-howix091	248	26	cycle	cycle	NN
cord-000180-howix091	248	27	into	into	IN
cord-000180-howix091	248	28	the	the	DT
cord-000180-howix091	248	29	G1	G1	NNP
cord-000180-howix091	248	30	/	/	SYM
cord-000180-howix091	248	31	S	S	NNP
cord-000180-howix091	248	32	phase	phase	NN
cord-000180-howix091	248	33	[	[	-LRB-
cord-000180-howix091	248	34	43	43	CD
cord-000180-howix091	248	35	]	]	-RRB-
cord-000180-howix091	248	36	.	.	.
cord-000180-howix091	249	1	Cyclin	Cyclin	NNP
cord-000180-howix091	249	2	-	-	HYPH
cord-000180-howix091	249	3	dependent	dependent	JJ
cord-000180-howix091	249	4	kinase	kinase	NN
cord-000180-howix091	249	5	2	2	CD
cord-000180-howix091	250	1	(	(	-LRB-
cord-000180-howix091	250	2	CDK2	CDK2	NNP
cord-000180-howix091	250	3	)	)	-RRB-
cord-000180-howix091	250	4	is	be	VBZ
cord-000180-howix091	250	5	one	one	CD
cord-000180-howix091	250	6	such	such	JJ
cord-000180-howix091	250	7	downstream	downstream	JJ
cord-000180-howix091	250	8	target	target	NN
cord-000180-howix091	250	9	of	of	IN
cord-000180-howix091	250	10	c	c	NN
cord-000180-howix091	250	11	-	-	HYPH
cord-000180-howix091	250	12	Myc	Myc	NNP
cord-000180-howix091	250	13	activity	activity	NN
cord-000180-howix091	250	14	,	,	,
cord-000180-howix091	250	15	as	as	RB
cord-000180-howix091	250	16	well	well	RB
cord-000180-howix091	250	17	as	as	IN
cord-000180-howix091	250	18	the	the	DT
cord-000180-howix091	250	19	Androgen	Androgen	NNP
cord-000180-howix091	250	20	pathway	pathway	NN
cord-000180-howix091	250	21	,	,	,
cord-000180-howix091	250	22	highlighting	highlight	VBG
cord-000180-howix091	250	23	the	the	DT
cord-000180-howix091	250	24	signalling	signal	VBG
cord-000180-howix091	250	25	cross	cross	NN
cord-000180-howix091	250	26	-	-	NN
cord-000180-howix091	250	27	talk	talk	NN
cord-000180-howix091	250	28	that	that	WDT
cord-000180-howix091	250	29	may	may	MD
cord-000180-howix091	250	30	occur	occur	VB
cord-000180-howix091	250	31	[	[	-LRB-
cord-000180-howix091	250	32	44	44	CD
cord-000180-howix091	250	33	]	]	-RRB-
cord-000180-howix091	250	34	.	.	.
cord-000180-howix091	251	1	CDK2	CDK2	NNP
cord-000180-howix091	251	2	is	be	VBZ
cord-000180-howix091	251	3	involved	involve	VBN
cord-000180-howix091	251	4	in	in	IN
cord-000180-howix091	251	5	the	the	DT
cord-000180-howix091	251	6	progression	progression	NN
cord-000180-howix091	251	7	of	of	IN
cord-000180-howix091	251	8	the	the	DT
cord-000180-howix091	251	9	cell	cell	NN
cord-000180-howix091	251	10	cycle	cycle	NN
cord-000180-howix091	251	11	from	from	IN
cord-000180-howix091	251	12	G1	G1	NNP
cord-000180-howix091	251	13	through	through	RP
cord-000180-howix091	251	14	to	to	IN
cord-000180-howix091	251	15	S	s	NN
cord-000180-howix091	251	16	phase	phase	NN
cord-000180-howix091	251	17	.	.	.
cord-000180-howix091	252	1	Transient	transient	JJ
cord-000180-howix091	252	2	activation	activation	NN
cord-000180-howix091	252	3	of	of	IN
cord-000180-howix091	252	4	CDK2	CDK2	NNP
cord-000180-howix091	252	5	was	be	VBD
cord-000180-howix091	252	6	shown	show	VBN
cord-000180-howix091	252	7	to	to	TO
cord-000180-howix091	252	8	occur	occur	VB
cord-000180-howix091	252	9	early	early	RB
cord-000180-howix091	252	10	in	in	IN
cord-000180-howix091	252	11	HSV-2	hsv-2	JJ
cord-000180-howix091	252	12	infection	infection	NN
cord-000180-howix091	252	13	at	at	IN
cord-000180-howix091	252	14	two	two	CD
cord-000180-howix091	252	15	hours	hour	NNS
cord-000180-howix091	252	16	post	post	NN
cord-000180-howix091	252	17	-	-	NN
cord-000180-howix091	252	18	infection	infection	NN
cord-000180-howix091	252	19	,	,	,
cord-000180-howix091	252	20	and	and	CC
cord-000180-howix091	252	21	is	be	VBZ
cord-000180-howix091	252	22	crucial	crucial	JJ
cord-000180-howix091	252	23	in	in	IN
cord-000180-howix091	252	24	early	early	JJ
cord-000180-howix091	252	25	HSV-1	hsv-1	NN
cord-000180-howix091	252	26	infection	infection	NN
cord-000180-howix091	252	27	[	[	-LRB-
cord-000180-howix091	252	28	45	45	CD
cord-000180-howix091	252	29	]	]	-RRB-
cord-000180-howix091	252	30	[	[	-LRB-
cord-000180-howix091	252	31	46	46	CD
cord-000180-howix091	252	32	]	]	-RRB-
cord-000180-howix091	252	33	.	.	.
cord-000180-howix091	253	1	Kinase	kinase	NN
cord-000180-howix091	253	2	action	action	NN
cord-000180-howix091	253	3	by	by	IN
cord-000180-howix091	253	4	the	the	DT
cord-000180-howix091	253	5	cyclin	cyclin	NN
cord-000180-howix091	253	6	A	A	NNP
cord-000180-howix091	253	7	/	/	SYM
cord-000180-howix091	253	8	CDK2	CDK2	NNP
cord-000180-howix091	253	9	complex	complex	NN
cord-000180-howix091	253	10	liberates	liberate	VBZ
cord-000180-howix091	253	11	the	the	DT
cord-000180-howix091	253	12	bound	bind	VBN
cord-000180-howix091	253	13	transcription	transcription	NN
cord-000180-howix091	253	14	factor	factor	NN
cord-000180-howix091	253	15	E2F	e2f	NN
cord-000180-howix091	253	16	from	from	IN
cord-000180-howix091	253	17	Rb	Rb	NNP
cord-000180-howix091	253	18	,	,	,
cord-000180-howix091	253	19	a	a	DT
cord-000180-howix091	253	20	transcription	transcription	NN
cord-000180-howix091	253	21	factor	factor	NN
cord-000180-howix091	253	22	that	that	WDT
cord-000180-howix091	253	23	has	have	VBZ
cord-000180-howix091	253	24	previously	previously	RB
cord-000180-howix091	253	25	been	be	VBN
cord-000180-howix091	253	26	shown	show	VBN
cord-000180-howix091	253	27	to	to	TO
cord-000180-howix091	253	28	be	be	VB
cord-000180-howix091	253	29	active	active	JJ
cord-000180-howix091	253	30	during	during	IN
cord-000180-howix091	253	31	HSV-1	HSV-1	NNS
cord-000180-howix091	253	32	infection	infection	NN
cord-000180-howix091	253	33	[	[	-LRB-
cord-000180-howix091	253	34	47	47	CD
cord-000180-howix091	253	35	]	]	-RRB-
cord-000180-howix091	253	36	.	.	.
cord-000180-howix091	254	1	Epithelial	epithelial	JJ
cord-000180-howix091	254	2	cells	cell	NNS
cord-000180-howix091	254	3	at	at	IN
cord-000180-howix091	254	4	the	the	DT
cord-000180-howix091	254	5	initial	initial	JJ
cord-000180-howix091	254	6	site	site	NN
cord-000180-howix091	254	7	of	of	IN
cord-000180-howix091	254	8	HSV-1	HSV-1	NNP
cord-000180-howix091	254	9	infection	infection	NN
cord-000180-howix091	254	10	in	in	IN
cord-000180-howix091	254	11	vivo	vivo	NN
cord-000180-howix091	254	12	are	be	VBP
cord-000180-howix091	254	13	likely	likely	JJ
cord-000180-howix091	254	14	to	to	TO
cord-000180-howix091	254	15	be	be	VB
cord-000180-howix091	254	16	in	in	IN
cord-000180-howix091	254	17	a	a	DT
cord-000180-howix091	254	18	resting	rest	VBG
cord-000180-howix091	254	19	state	state	NN
cord-000180-howix091	254	20	,	,	,
cord-000180-howix091	254	21	necessitating	necessitate	VBG
cord-000180-howix091	254	22	the	the	DT
cord-000180-howix091	254	23	virus	virus	NN
cord-000180-howix091	254	24	to	to	TO
cord-000180-howix091	254	25	evolve	evolve	VB
cord-000180-howix091	254	26	a	a	DT
cord-000180-howix091	254	27	preentry	preentry	NN
cord-000180-howix091	254	28	signalling	signalling	NN
cord-000180-howix091	254	29	mechanism	mechanism	NN
cord-000180-howix091	254	30	by	by	IN
cord-000180-howix091	254	31	which	which	WDT
cord-000180-howix091	254	32	to	to	TO
cord-000180-howix091	254	33	stimulate	stimulate	VB
cord-000180-howix091	254	34	the	the	DT
cord-000180-howix091	254	35	cell	cell	NN
cord-000180-howix091	254	36	to	to	TO
cord-000180-howix091	254	37	provide	provide	VB
cord-000180-howix091	254	38	host	host	NN
cord-000180-howix091	254	39	factors	factor	NNS
cord-000180-howix091	254	40	that	that	WDT
cord-000180-howix091	254	41	are	be	VBP
cord-000180-howix091	254	42	necessary	necessary	JJ
cord-000180-howix091	254	43	for	for	IN
cord-000180-howix091	254	44	viral	viral	JJ
cord-000180-howix091	254	45	replication	replication	NN
cord-000180-howix091	254	46	.	.	.
cord-000180-howix091	255	1	We	-PRON-	PRP
cord-000180-howix091	255	2	have	have	VBP
cord-000180-howix091	255	3	demonstrated	demonstrate	VBN
cord-000180-howix091	255	4	that	that	IN
cord-000180-howix091	255	5	signalling	signal	VBG
cord-000180-howix091	255	6	induced	induce	VBN
cord-000180-howix091	255	7	by	by	IN
cord-000180-howix091	255	8	HSV-1	hsv-1	NN
cord-000180-howix091	255	9	glycoproteins	glycoprotein	NNS
cord-000180-howix091	255	10	,	,	,
cord-000180-howix091	255	11	primarily	primarily	RB
cord-000180-howix091	255	12	gD	gD	NNP
cord-000180-howix091	255	13	,	,	,
cord-000180-howix091	255	14	has	have	VBZ
cord-000180-howix091	255	15	the	the	DT
cord-000180-howix091	255	16	potential	potential	NN
cord-000180-howix091	255	17	to	to	TO
cord-000180-howix091	255	18	:	:	:
cord-000180-howix091	255	19	activate	activate	VB
cord-000180-howix091	255	20	cellular	cellular	JJ
cord-000180-howix091	255	21	transcription	transcription	NN
cord-000180-howix091	255	22	factors	factor	NNS
cord-000180-howix091	255	23	that	that	WDT
cord-000180-howix091	255	24	augment	augment	VBP
cord-000180-howix091	255	25	viral	viral	JJ
cord-000180-howix091	255	26	gene	gene	NN
cord-000180-howix091	255	27	transcription	transcription	NN
cord-000180-howix091	255	28	,	,	,
cord-000180-howix091	255	29	differentially	differentially	RB
cord-000180-howix091	255	30	express	express	VB
cord-000180-howix091	255	31	a	a	DT
cord-000180-howix091	255	32	number	number	NN
cord-000180-howix091	255	33	of	of	IN
cord-000180-howix091	255	34	cellular	cellular	JJ
cord-000180-howix091	255	35	genes	gene	NNS
cord-000180-howix091	255	36	so	so	IN
cord-000180-howix091	255	37	as	as	IN
cord-000180-howix091	255	38	to	to	TO
cord-000180-howix091	255	39	condition	condition	VB
cord-000180-howix091	255	40	the	the	DT
cord-000180-howix091	255	41	cell	cell	NN
cord-000180-howix091	255	42	for	for	IN
cord-000180-howix091	255	43	optimal	optimal	JJ
cord-000180-howix091	255	44	replication	replication	NN
cord-000180-howix091	255	45	or	or	CC
cord-000180-howix091	255	46	,	,	,
cord-000180-howix091	255	47	alternatively	alternatively	RB
cord-000180-howix091	255	48	,	,	,
cord-000180-howix091	255	49	signal	signal	NN
cord-000180-howix091	255	50	transduction	transduction	NN
cord-000180-howix091	255	51	may	may	MD
cord-000180-howix091	255	52	occur	occur	VB
cord-000180-howix091	255	53	as	as	IN
cord-000180-howix091	255	54	a	a	DT
cord-000180-howix091	255	55	secondary	secondary	JJ
cord-000180-howix091	255	56	effect	effect	NN
cord-000180-howix091	255	57	to	to	IN
cord-000180-howix091	255	58	the	the	DT
cord-000180-howix091	255	59	appropriation	appropriation	NN
cord-000180-howix091	255	60	of	of	IN
cord-000180-howix091	255	61	cellular	cellular	JJ
cord-000180-howix091	255	62	receptors	receptor	NNS
cord-000180-howix091	255	63	to	to	TO
cord-000180-howix091	255	64	achieve	achieve	VB
cord-000180-howix091	255	65	viral	viral	JJ
cord-000180-howix091	255	66	entry	entry	NN
cord-000180-howix091	255	67	.	.	.
cord-000180-howix091	255	68	 	 	_SP
cord-000180-howix091	256	1	Involvement	involvement	NN
cord-000180-howix091	256	2	of	of	IN
cord-000180-howix091	256	3	gD	gD	NNP
cord-000180-howix091	256	4	/	/	SYM
cord-000180-howix091	256	5	HVEM	HVEM	NNP
cord-000180-howix091	256	6	interaction	interaction	NN
cord-000180-howix091	256	7	in	in	IN
cord-000180-howix091	256	8	NF	NF	NNP
cord-000180-howix091	256	9	-	-	HYPH
cord-000180-howix091	256	10	kB	kB	NNP
cord-000180-howix091	256	11	-	-	HYPH
cord-000180-howix091	256	12	dependent	dependent	JJ
cord-000180-howix091	256	13	inhibition	inhibition	NN
cord-000180-howix091	256	14	of	of	IN
cord-000180-howix091	256	15	apoptosis	apoptosis	NN
cord-000180-howix091	256	16	by	by	IN
cord-000180-howix091	256	17	HSV-1	hsv-1	NN
cord-000180-howix091	256	18	gD	gD	NNP
cord-000180-howix091	256	19	Entry	Entry	NNP
cord-000180-howix091	256	20	of	of	IN
cord-000180-howix091	256	21	herpesviruses	herpesviruses	NNP
cord-000180-howix091	256	22	into	into	IN
cord-000180-howix091	256	23	mammalian	mammalian	JJ
cord-000180-howix091	256	24	cells	cell	NNS
cord-000180-howix091	257	1	The	the	DT
cord-000180-howix091	257	2	role	role	NN
cord-000180-howix091	257	3	of	of	IN
cord-000180-howix091	257	4	glycoprotein	glycoprotein	NN
cord-000180-howix091	257	5	H	h	NN
cord-000180-howix091	257	6	in	in	IN
cord-000180-howix091	257	7	herpesvirus	herpesvirus	NN
cord-000180-howix091	257	8	membrane	membrane	NN
cord-000180-howix091	257	9	fusion	fusion	NN
cord-000180-howix091	257	10	Herpes	Herpes	NNP
cord-000180-howix091	257	11	simplex	simplex	NN
cord-000180-howix091	257	12	virus	virus	NN
cord-000180-howix091	257	13	type	type	NN
cord-000180-howix091	257	14	1	1	CD
cord-000180-howix091	257	15	glycoprotein	glycoprotein	NN
cord-000180-howix091	257	16	H	h	NN
cord-000180-howix091	257	17	binds	bind	VBZ
cord-000180-howix091	257	18	to	to	IN
cord-000180-howix091	257	19	alphavbeta3	alphavbeta3	NN
cord-000180-howix091	258	1	integrins	integrins	NNP
cord-000180-howix091	258	2	PILRalpha	PILRalpha	NNP
cord-000180-howix091	258	3	is	be	VBZ
cord-000180-howix091	258	4	a	a	DT
cord-000180-howix091	258	5	herpes	herpes	NN
cord-000180-howix091	258	6	simplex	simplex	NN
cord-000180-howix091	258	7	virus-1	virus-1	NNP
cord-000180-howix091	258	8	entry	entry	NN
cord-000180-howix091	258	9	coreceptor	coreceptor	NN
cord-000180-howix091	258	10	that	that	IN
cord-000180-howix091	258	11	associates	associate	NNS
cord-000180-howix091	258	12	with	with	IN
cord-000180-howix091	258	13	glycoprotein	glycoprotein	NN
cord-000180-howix091	258	14	B	B	NNP
cord-000180-howix091	258	15	Protection	Protection	NNP
cord-000180-howix091	258	16	by	by	IN
cord-000180-howix091	258	17	Herpes	Herpes	NNP
cord-000180-howix091	258	18	Simplex	Simplex	NNP
cord-000180-howix091	258	19	Virus	Virus	NNP
cord-000180-howix091	258	20	Glycoprotein	Glycoprotein	NNP
cord-000180-howix091	258	21	D	D	NNP
cord-000180-howix091	258	22	against	against	IN
cord-000180-howix091	258	23	Fas	Fas	NNP
cord-000180-howix091	258	24	-	-	HYPH
cord-000180-howix091	258	25	mediated	mediate	VBN
cord-000180-howix091	258	26	Apoptosis	apoptosis	NN
cord-000180-howix091	258	27	:	:	:
cord-000180-howix091	258	28	ROLE	role	NN
cord-000180-howix091	258	29	OF	of	IN
cord-000180-howix091	258	30	NUCLEAR	nuclear	JJ
cord-000180-howix091	258	31	FACTOR	factor	NN
cord-000180-howix091	258	32	{	{	-LRB-
cord-000180-howix091	258	33	kappa}B	kappa}B	NNP
cord-000180-howix091	258	34	Herpes	Herpes	NNP
cord-000180-howix091	258	35	Simplex	Simplex	NNP
cord-000180-howix091	258	36	Virus	Virus	NNP
cord-000180-howix091	258	37	Type	type	NN
cord-000180-howix091	258	38	1	1	CD
cord-000180-howix091	258	39	Induction	Induction	NNP
cord-000180-howix091	258	40	of	of	IN
cord-000180-howix091	258	41	Persistent	Persistent	NNP
cord-000180-howix091	258	42	NF	NF	NNP
cord-000180-howix091	258	43	-	-	HYPH
cord-000180-howix091	258	44	kB	kB	NNP
cord-000180-howix091	258	45	Nuclear	Nuclear	NNP
cord-000180-howix091	258	46	Translocation	Translocation	NNP
cord-000180-howix091	258	47	Increases	increase	VBZ
cord-000180-howix091	258	48	the	the	DT
cord-000180-howix091	258	49	Efficiency	Efficiency	NNP
cord-000180-howix091	258	50	of	of	IN
cord-000180-howix091	258	51	Virus	Virus	NNP
cord-000180-howix091	258	52	Replication*1	replication*1	CD
cord-000180-howix091	258	53	Herpes	Herpes	NNP
cord-000180-howix091	258	54	Simplex	Simplex	NNP
cord-000180-howix091	258	55	Virus	virus	NN
cord-000180-howix091	259	1	Disrupts	disrupt	VBZ
cord-000180-howix091	259	2	NF-{kappa}B	NF-{kappa}B	NNP
cord-000180-howix091	259	3	Regulation	regulation	NN
cord-000180-howix091	259	4	by	by	IN
cord-000180-howix091	259	5	Blocking	block	VBG
cord-000180-howix091	259	6	Its	-PRON-	PRP$
cord-000180-howix091	259	7	Recruitment	Recruitment	NNP
cord-000180-howix091	259	8	on	on	IN
cord-000180-howix091	259	9	the	the	DT
cord-000180-howix091	259	10	I{kappa}B{alpha	i{kappa}b{alpha	NN
cord-000180-howix091	259	11	}	}	-RRB-
cord-000180-howix091	259	12	Promoter	Promoter	NNP
cord-000180-howix091	259	13	and	and	CC
cord-000180-howix091	259	14	Directing	direct	VBG
cord-000180-howix091	259	15	the	the	DT
cord-000180-howix091	259	16	Factor	factor	NN
cord-000180-howix091	259	17	on	on	IN
cord-000180-howix091	259	18	Viral	Viral	NNP
cord-000180-howix091	259	19	Genes	Genes	NNPS
cord-000180-howix091	259	20	Signaling	Signaling	NNP
cord-000180-howix091	259	21	Pathway	Pathway	NNP
cord-000180-howix091	259	22	Used	use	VBN
cord-000180-howix091	259	23	by	by	IN
cord-000180-howix091	259	24	HSV-1	HSV-1	NNS
cord-000180-howix091	259	25	to	to	TO
cord-000180-howix091	259	26	Induce	induce	VB
cord-000180-howix091	260	1	NF	NF	NNP
cord-000180-howix091	260	2	-	-	HYPH
cord-000180-howix091	260	3	kB	kB	NNP
cord-000180-howix091	260	4	Activation	Activation	NNP
cord-000180-howix091	260	5	Global	Global	NNP
cord-000180-howix091	260	6	modulation	modulation	NN
cord-000180-howix091	260	7	of	of	IN
cord-000180-howix091	260	8	cellular	cellular	JJ
cord-000180-howix091	260	9	transcription	transcription	NN
cord-000180-howix091	260	10	by	by	IN
cord-000180-howix091	260	11	human	human	JJ
cord-000180-howix091	260	12	cytomegalovirus	cytomegalovirus	NN
cord-000180-howix091	260	13	is	be	VBZ
cord-000180-howix091	260	14	initiated	initiate	VBN
cord-000180-howix091	260	15	by	by	IN
cord-000180-howix091	260	16	viral	viral	JJ
cord-000180-howix091	260	17	glycoprotein	glycoprotein	NN
cord-000180-howix091	260	18	B	B	NNP
cord-000180-howix091	260	19	Binding	Binding	NNP
cord-000180-howix091	260	20	of	of	IN
cord-000180-howix091	260	21	the	the	DT
cord-000180-howix091	260	22	epsteinbarr	epsteinbarr	NNP
cord-000180-howix091	260	23	virus	virus	NNP
cord-000180-howix091	260	24	major	major	JJ
cord-000180-howix091	260	25	envelope	envelope	NN
cord-000180-howix091	260	26	glycoprotein	glycoprotein	VBG
cord-000180-howix091	260	27	gp350	gp350	CD
cord-000180-howix091	260	28	results	result	NNS
cord-000180-howix091	260	29	in	in	IN
cord-000180-howix091	260	30	the	the	DT
cord-000180-howix091	260	31	upregulation	upregulation	NN
cord-000180-howix091	260	32	of	of	IN
cord-000180-howix091	260	33	the	the	DT
cord-000180-howix091	260	34	TNF	TNF	NNP
cord-000180-howix091	260	35	-	-	:
cord-000180-howix091	260	36	a	a	DT
cord-000180-howix091	260	37	gene	gene	NN
cord-000180-howix091	260	38	expression	expression	NN
cord-000180-howix091	260	39	in	in	IN
cord-000180-howix091	260	40	monocytic	monocytic	JJ
cord-000180-howix091	260	41	cells	cell	NNS
cord-000180-howix091	260	42	via	via	IN
cord-000180-howix091	260	43	NF	NF	NNP
cord-000180-howix091	260	44	-	-	HYPH
cord-000180-howix091	260	45	kb	kb	NNP
cord-000180-howix091	260	46	involving	involve	VBG
cord-000180-howix091	260	47	PKC	PKC	NNP
cord-000180-howix091	260	48	,	,	,
cord-000180-howix091	260	49	PI3-K	PI3-K	NNP
cord-000180-howix091	260	50	and	and	CC
cord-000180-howix091	260	51	tyrosine	tyrosine	NN
cord-000180-howix091	260	52	kinases1	kinases1	NN
cord-000180-howix091	261	1	Epstein	Epstein	NNP
cord-000180-howix091	261	2	-	-	HYPH
cord-000180-howix091	261	3	Barr	Barr	NNP
cord-000180-howix091	261	4	virus	virus	NN
cord-000180-howix091	261	5	and	and	CC
cord-000180-howix091	261	6	its	-PRON-	PRP$
cord-000180-howix091	261	7	glycoprotein-350	glycoprotein-350	NNP
cord-000180-howix091	261	8	upregulate	upregulate	VB
cord-000180-howix091	262	1	IL-6	IL-6	NNP
cord-000180-howix091	262	2	in	in	IN
cord-000180-howix091	262	3	human	human	JJ
cord-000180-howix091	262	4	B	b	NN
cord-000180-howix091	262	5	-	-	,
cord-000180-howix091	262	6	lymphocytes	lymphocyte	NNS
cord-000180-howix091	262	7	via	via	IN
cord-000180-howix091	262	8	CD21	CD21	NNP
cord-000180-howix091	262	9	,	,	,
cord-000180-howix091	262	10	involving	involve	VBG
cord-000180-howix091	262	11	activation	activation	NN
cord-000180-howix091	262	12	of	of	IN
cord-000180-howix091	262	13	NF	NF	NNP
cord-000180-howix091	262	14	-	-	HYPH
cord-000180-howix091	262	15	kB	kB	NNP
cord-000180-howix091	262	16	and	and	CC
cord-000180-howix091	262	17	different	different	JJ
cord-000180-howix091	262	18	signaling	signal	VBG
cord-000180-howix091	262	19	pathways1	pathways1	NN
cord-000180-howix091	262	20	Role	role	NN
cord-000180-howix091	262	21	of	of	IN
cord-000180-howix091	262	22	glycoprotein	glycoprotein	NN
cord-000180-howix091	262	23	B	b	NN
cord-000180-howix091	262	24	of	of	IN
cord-000180-howix091	262	25	herpes	herpes	NNP
cord-000180-howix091	262	26	simplex	simplex	NNP
cord-000180-howix091	262	27	virus	virus	NN
cord-000180-howix091	262	28	type	type	NN
cord-000180-howix091	262	29	1	1	CD
cord-000180-howix091	262	30	in	in	IN
cord-000180-howix091	262	31	viral	viral	JJ
cord-000180-howix091	262	32	entry	entry	NN
cord-000180-howix091	262	33	and	and	CC
cord-000180-howix091	262	34	cell	cell	NN
cord-000180-howix091	262	35	fusion	fusion	NN
cord-000180-howix091	262	36	Construction	construction	NN
cord-000180-howix091	262	37	and	and	CC
cord-000180-howix091	262	38	properties	property	NNS
cord-000180-howix091	262	39	of	of	IN
cord-000180-howix091	262	40	a	a	DT
cord-000180-howix091	262	41	mutant	mutant	NN
cord-000180-howix091	262	42	of	of	IN
cord-000180-howix091	262	43	herpes	herpes	NNP
cord-000180-howix091	262	44	simplex	simplex	NNP
cord-000180-howix091	262	45	virus	virus	NN
cord-000180-howix091	262	46	type	type	NN
cord-000180-howix091	262	47	1	1	CD
cord-000180-howix091	262	48	with	with	IN
cord-000180-howix091	262	49	glycoprotein	glycoprotein	NN
cord-000180-howix091	262	50	H	h	NN
cord-000180-howix091	262	51	coding	coding	NN
cord-000180-howix091	262	52	sequences	sequence	NNS
cord-000180-howix091	262	53	deleted	delete	VBD
cord-000180-howix091	262	54	A	a	DT
cord-000180-howix091	262	55	herpes	herpe	NNS
cord-000180-howix091	262	56	simplex	simplex	NN
cord-000180-howix091	262	57	virus	virus	NN
cord-000180-howix091	262	58	mutant	mutant	JJ
cord-000180-howix091	262	59	in	in	IN
cord-000180-howix091	262	60	which	which	WDT
cord-000180-howix091	262	61	glycoprotein	glycoprotein	NN
cord-000180-howix091	262	62	D	d	NN
cord-000180-howix091	262	63	sequences	sequence	NNS
cord-000180-howix091	262	64	are	be	VBP
cord-000180-howix091	262	65	replaced	replace	VBN
cord-000180-howix091	262	66	by	by	IN
cord-000180-howix091	262	67	beta	beta	JJ
cord-000180-howix091	262	68	-	-	HYPH
cord-000180-howix091	262	69	galactosidase	galactosidase	NN
cord-000180-howix091	262	70	sequences	sequence	NNS
cord-000180-howix091	262	71	binds	bind	VBZ
cord-000180-howix091	262	72	to	to	IN
cord-000180-howix091	262	73	but	but	CC
cord-000180-howix091	262	74	is	be	VBZ
cord-000180-howix091	262	75	unable	unable	JJ
cord-000180-howix091	262	76	to	to	TO
cord-000180-howix091	262	77	penetrate	penetrate	VB
cord-000180-howix091	262	78	into	into	IN
cord-000180-howix091	262	79	cells	cell	NNS
cord-000180-howix091	263	1	A	a	DT
cord-000180-howix091	263	2	mutant	mutant	JJ
cord-000180-howix091	263	3	herpes	herpes	NN
cord-000180-howix091	263	4	simplex	simplex	NN
cord-000180-howix091	263	5	virus	virus	NN
cord-000180-howix091	263	6	type	type	NN
cord-000180-howix091	263	7	1	1	CD
cord-000180-howix091	263	8	unable	unable	JJ
cord-000180-howix091	263	9	to	to	TO
cord-000180-howix091	263	10	express	express	VB
cord-000180-howix091	263	11	glycoprotein	glycoprotein	NN
cord-000180-howix091	263	12	L	l	NN
cord-000180-howix091	263	13	can	can	MD
cord-000180-howix091	263	14	not	not	RB
cord-000180-howix091	263	15	enter	enter	VB
cord-000180-howix091	263	16	cells	cell	NNS
cord-000180-howix091	263	17	,	,	,
cord-000180-howix091	263	18	and	and	CC
cord-000180-howix091	263	19	its	-PRON-	PRP$
cord-000180-howix091	263	20	particles	particle	NNS
cord-000180-howix091	263	21	lack	lack	VBP
cord-000180-howix091	263	22	glycoprotein	glycoprotein	NN
cord-000180-howix091	263	23	H	h	NN
cord-000180-howix091	263	24	Herpes	Herpes	NNP
cord-000180-howix091	264	1	Simplex	Simplex	NNP
cord-000180-howix091	264	2	Virus	Virus	NNP
cord-000180-howix091	265	1	Tegument	Tegument	NNP
cord-000180-howix091	265	2	Protein	Protein	NNP
cord-000180-howix091	266	1	VP16	VP16	NNP
cord-000180-howix091	266	2	Is	be	VBZ
cord-000180-howix091	266	3	a	a	DT
cord-000180-howix091	266	4	Component	Component	NNP
cord-000180-howix091	266	5	of	of	IN
cord-000180-howix091	266	6	Primary	Primary	NNP
cord-000180-howix091	266	7	Enveloped	Enveloped	NNP
cord-000180-howix091	266	8	Virions	Virions	NNP
cord-000180-howix091	267	1	A	a	DT
cord-000180-howix091	267	2	study	study	NN
cord-000180-howix091	267	3	of	of	IN
cord-000180-howix091	267	4	primary	primary	JJ
cord-000180-howix091	267	5	neuronal	neuronal	JJ
cord-000180-howix091	267	6	infection	infection	NN
cord-000180-howix091	267	7	by	by	IN
cord-000180-howix091	267	8	mutants	mutant	NNS
cord-000180-howix091	267	9	of	of	IN
cord-000180-howix091	267	10	herpes	herpe	NNS
cord-000180-howix091	267	11	simplex	simplex	NNP
cord-000180-howix091	267	12	virus	virus	NN
cord-000180-howix091	267	13	type	type	NN
cord-000180-howix091	267	14	1	1	CD
cord-000180-howix091	267	15	lacking	lack	VBG
cord-000180-howix091	267	16	dispensable	dispensable	JJ
cord-000180-howix091	267	17	and	and	CC
cord-000180-howix091	267	18	nondispensable	nondispensable	JJ
cord-000180-howix091	267	19	glycoproteins	glycoprotein	NNS
cord-000180-howix091	268	1	A	a	DT
cord-000180-howix091	268	2	genetically	genetically	RB
cord-000180-howix091	268	3	inactivated	inactivate	VBN
cord-000180-howix091	268	4	herpes	herpes	NN
cord-000180-howix091	268	5	simplex	simplex	NN
cord-000180-howix091	268	6	virus	virus	NN
cord-000180-howix091	268	7	type	type	NN
cord-000180-howix091	268	8	2	2	CD
cord-000180-howix091	269	1	(	(	-LRB-
cord-000180-howix091	269	2	HSV-2	HSV-2	NNP
cord-000180-howix091	269	3	)	)	-RRB-
cord-000180-howix091	269	4	vaccine	vaccine	NN
cord-000180-howix091	269	5	provides	provide	VBZ
cord-000180-howix091	269	6	effective	effective	JJ
cord-000180-howix091	269	7	protection	protection	NN
cord-000180-howix091	269	8	against	against	IN
cord-000180-howix091	269	9	primary	primary	JJ
cord-000180-howix091	269	10	and	and	CC
cord-000180-howix091	269	11	recurrent	recurrent	JJ
cord-000180-howix091	269	12	HSV-2	HSV-2	NNP
cord-000180-howix091	269	13	disease	disease	NN
cord-000180-howix091	269	14	Assembly	Assembly	NNP
cord-000180-howix091	269	15	and	and	CC
cord-000180-howix091	269	16	Organization	Organization	NNP
cord-000180-howix091	269	17	of	of	IN
cord-000180-howix091	269	18	Glycoproteins	Glycoproteins	NNP
cord-000180-howix091	269	19	B	B	NNP
cord-000180-howix091	269	20	,	,	,
cord-000180-howix091	269	21	C	C	NNP
cord-000180-howix091	269	22	,	,	,
cord-000180-howix091	269	23	D	D	NNP
cord-000180-howix091	269	24	,	,	,
cord-000180-howix091	269	25	and	and	CC
cord-000180-howix091	269	26	H	h	NN
cord-000180-howix091	269	27	in	in	IN
cord-000180-howix091	269	28	Herpes	Herpes	NNP
cord-000180-howix091	269	29	Simplex	Simplex	NNP
cord-000180-howix091	269	30	Virus	Virus	NNP
cord-000180-howix091	269	31	Type	type	NN
cord-000180-howix091	269	32	1	1	CD
cord-000180-howix091	269	33	Particles	particle	NNS
cord-000180-howix091	269	34	Lacking	lack	VBG
cord-000180-howix091	269	35	Individual	individual	JJ
cord-000180-howix091	269	36	Glycoproteins	Glycoproteins	NNPS
cord-000180-howix091	269	37	:	:	:
cord-000180-howix091	270	1	No	no	DT
cord-000180-howix091	270	2	Evidence	evidence	NN
cord-000180-howix091	270	3	for	for	IN
cord-000180-howix091	270	4	the	the	DT
cord-000180-howix091	270	5	Formation	Formation	NNP
cord-000180-howix091	270	6	of	of	IN
cord-000180-howix091	270	7	a	a	DT
cord-000180-howix091	270	8	Complex	Complex	NNP
cord-000180-howix091	270	9	of	of	IN
cord-000180-howix091	270	10	These	these	DT
cord-000180-howix091	270	11	Molecules	molecule	NNS
cord-000180-howix091	270	12	Electron	Electron	NNP
cord-000180-howix091	270	13	microscopic	microscopic	JJ
cord-000180-howix091	270	14	particle	particle	NN
cord-000180-howix091	270	15	counts	count	VBZ
cord-000180-howix091	270	16	on	on	IN
cord-000180-howix091	270	17	herpes	herpes	NN
cord-000180-howix091	270	18	virus	virus	NN
cord-000180-howix091	270	19	using	use	VBG
cord-000180-howix091	270	20	the	the	DT
cord-000180-howix091	270	21	phosphotungstate	phosphotungstate	JJ
cord-000180-howix091	270	22	negative	negative	JJ
cord-000180-howix091	270	23	staining	staining	NN
cord-000180-howix091	270	24	technique	technique	NN
cord-000180-howix091	270	25	Virus	virus	NN
cord-000180-howix091	270	26	-	-	HYPH
cord-000180-howix091	270	27	Cell	Cell	NNP
cord-000180-howix091	270	28	Interactions	Interactions	NNPS
cord-000180-howix091	270	29	Regulating	Regulating	NNP
cord-000180-howix091	270	30	Induction	Induction	NNP
cord-000180-howix091	270	31	of	of	IN
cord-000180-howix091	270	32	Tumor	Tumor	NNP
cord-000180-howix091	270	33	Necrosis	necrosis	NN
cord-000180-howix091	270	34	Factor	Factor	NNP
cord-000180-howix091	270	35	Alpha	Alpha	NNP
cord-000180-howix091	270	36	Production	Production	NNP
cord-000180-howix091	270	37	in	in	IN
cord-000180-howix091	270	38	Macrophages	macrophage	NNS
cord-000180-howix091	270	39	Infected	infect	VBN
cord-000180-howix091	270	40	with	with	IN
cord-000180-howix091	270	41	Herpes	Herpes	NNP
cord-000180-howix091	270	42	Simplex	Simplex	NNP
cord-000180-howix091	270	43	Virus	Virus	NNP
cord-000180-howix091	270	44	Primer3	Primer3	NNP
cord-000180-howix091	270	45	on	on	IN
cord-000180-howix091	270	46	the	the	DT
cord-000180-howix091	270	47	WWW	WWW	NNP
cord-000180-howix091	270	48	for	for	IN
cord-000180-howix091	270	49	general	general	JJ
cord-000180-howix091	270	50	users	user	NNS
cord-000180-howix091	270	51	and	and	CC
cord-000180-howix091	270	52	for	for	IN
cord-000180-howix091	270	53	biologist	biologist	NN
cord-000180-howix091	270	54	programmers	programmer	NNS
cord-000180-howix091	270	55	A	a	DT
cord-000180-howix091	270	56	new	new	JJ
cord-000180-howix091	270	57	mathematical	mathematical	JJ
cord-000180-howix091	270	58	model	model	NN
cord-000180-howix091	270	59	for	for	IN
cord-000180-howix091	270	60	relative	relative	JJ
cord-000180-howix091	270	61	quantification	quantification	NN
cord-000180-howix091	270	62	in	in	IN
cord-000180-howix091	270	63	realtime	realtime	JJ
cord-000180-howix091	270	64	RT	RT	NNP
cord-000180-howix091	270	65	-	-	HYPH
cord-000180-howix091	270	66	PCR	PCR	NNP
cord-000180-howix091	270	67	An	an	DT
cord-000180-howix091	270	68	analysis	analysis	NN
cord-000180-howix091	270	69	of	of	IN
cord-000180-howix091	270	70	the	the	DT
cord-000180-howix091	270	71	biological	biological	JJ
cord-000180-howix091	270	72	properties	property	NNS
cord-000180-howix091	270	73	of	of	IN
cord-000180-howix091	270	74	monoclonal	monoclonal	JJ
cord-000180-howix091	270	75	antibodies	antibody	NNS
cord-000180-howix091	270	76	against	against	IN
cord-000180-howix091	270	77	glycoprotein	glycoprotein	NN
cord-000180-howix091	270	78	D	D	NNP
cord-000180-howix091	270	79	of	of	IN
cord-000180-howix091	270	80	herpes	herpes	NNP
cord-000180-howix091	270	81	simplex	simplex	NNP
cord-000180-howix091	270	82	virus	virus	NN
cord-000180-howix091	270	83	and	and	CC
cord-000180-howix091	270	84	identification	identification	NN
cord-000180-howix091	270	85	of	of	IN
cord-000180-howix091	270	86	amino	amino	JJ
cord-000180-howix091	270	87	acid	acid	NN
cord-000180-howix091	270	88	substitutions	substitution	NNS
cord-000180-howix091	270	89	that	that	WDT
cord-000180-howix091	270	90	confer	confer	VBP
cord-000180-howix091	270	91	resistance	resistance	NN
cord-000180-howix091	270	92	to	to	IN
cord-000180-howix091	270	93	neutralization	neutralization	NN
cord-000180-howix091	270	94	Monoclonal	monoclonal	JJ
cord-000180-howix091	270	95	antibodies	antibody	NNS
cord-000180-howix091	270	96	to	to	IN
cord-000180-howix091	270	97	three	three	CD
cord-000180-howix091	270	98	non	non	JJ
cord-000180-howix091	270	99	-	-	JJ
cord-000180-howix091	270	100	glycosylated	glycosylated	JJ
cord-000180-howix091	270	101	antigens	antigen	NNS
cord-000180-howix091	270	102	of	of	IN
cord-000180-howix091	270	103	herpes	herpes	NN
cord-000180-howix091	270	104	simplex	simplex	NNP
cord-000180-howix091	270	105	virus	virus	NN
cord-000180-howix091	270	106	type	type	NN
cord-000180-howix091	270	107	2	2	CD
cord-000180-howix091	271	1	An	an	DT
cord-000180-howix091	271	2	endoplasmic	endoplasmic	NN
cord-000180-howix091	271	3	reticulumretained	reticulumretaine	VBN
cord-000180-howix091	271	4	herpes	herpes	NN
cord-000180-howix091	271	5	simplex	simplex	NNP
cord-000180-howix091	271	6	virus	virus	NN
cord-000180-howix091	271	7	glycoprotein	glycoprotein	NN
cord-000180-howix091	271	8	H	H	NNP
cord-000180-howix091	271	9	is	be	VBZ
cord-000180-howix091	271	10	absent	absent	JJ
cord-000180-howix091	271	11	from	from	IN
cord-000180-howix091	271	12	secreted	secrete	VBN
cord-000180-howix091	271	13	virions	virion	NNS
cord-000180-howix091	271	14	:	:	:
cord-000180-howix091	271	15	evidence	evidence	NN
cord-000180-howix091	271	16	for	for	IN
cord-000180-howix091	271	17	reenvelopment	reenvelopment	NN
cord-000180-howix091	271	18	during	during	IN
cord-000180-howix091	271	19	egress	egress	NN
cord-000180-howix091	271	20	Modulation	modulation	NN
cord-000180-howix091	271	21	of	of	IN
cord-000180-howix091	271	22	firefly	firefly	NN
cord-000180-howix091	271	23	luciferase	luciferase	NN
cord-000180-howix091	271	24	stability	stability	NN
cord-000180-howix091	271	25	and	and	CC
cord-000180-howix091	271	26	impact	impact	NN
cord-000180-howix091	271	27	on	on	IN
cord-000180-howix091	271	28	studies	study	NNS
cord-000180-howix091	271	29	of	of	IN
cord-000180-howix091	271	30	gene	gene	NN
cord-000180-howix091	271	31	regulation	regulation	NN
cord-000180-howix091	271	32	Induction	Induction	NNP
cord-000180-howix091	271	33	of	of	IN
cord-000180-howix091	271	34	Interferona	Interferona	NNP
cord-000180-howix091	271	35	by	by	IN
cord-000180-howix091	271	36	Glycoprotein	Glycoprotein	NNP
cord-000180-howix091	271	37	D	D	NNP
cord-000180-howix091	271	38	of	of	IN
cord-000180-howix091	271	39	Herpes	Herpes	NNP
cord-000180-howix091	271	40	Simplex	Simplex	NNP
cord-000180-howix091	271	41	Virus	Virus	NNP
cord-000180-howix091	271	42	:	:	:
cord-000180-howix091	272	1	A	a	DT
cord-000180-howix091	272	2	Possible	possible	JJ
cord-000180-howix091	272	3	Role	role	NN
cord-000180-howix091	272	4	of	of	IN
cord-000180-howix091	272	5	Chemokine	Chemokine	NNP
cord-000180-howix091	272	6	Receptors	Receptors	NNPS
cord-000180-howix091	272	7	Activation	Activation	NNP
cord-000180-howix091	272	8	of	of	IN
cord-000180-howix091	272	9	Interferon	Interferon	NNP
cord-000180-howix091	272	10	Response	Response	NNP
cord-000180-howix091	272	11	Factor-3	Factor-3	NNP
cord-000180-howix091	272	12	in	in	IN
cord-000180-howix091	272	13	Human	Human	NNP
cord-000180-howix091	272	14	Cells	cell	NNS
cord-000180-howix091	272	15	Infected	infect	VBN
cord-000180-howix091	272	16	with	with	IN
cord-000180-howix091	272	17	Herpes	Herpes	NNP
cord-000180-howix091	272	18	Simplex	Simplex	NNP
cord-000180-howix091	272	19	Virus	Virus	NNP
cord-000180-howix091	272	20	Type	Type	NNP
cord-000180-howix091	272	21	1	1	CD
cord-000180-howix091	272	22	or	or	CC
cord-000180-howix091	272	23	Human	Human	NNP
cord-000180-howix091	272	24	Cytomegalovirus	Cytomegalovirus	NNP
cord-000180-howix091	273	1	Single	single	JJ
cord-000180-howix091	273	2	amino	amino	NN
cord-000180-howix091	273	3	acid	acid	NN
cord-000180-howix091	273	4	changes	change	NNS
cord-000180-howix091	273	5	in	in	IN
cord-000180-howix091	273	6	the	the	DT
cord-000180-howix091	273	7	viral	viral	JJ
cord-000180-howix091	273	8	glycoprotein	glycoprotein	NN
cord-000180-howix091	273	9	M	m	CD
cord-000180-howix091	273	10	affect	affect	NN
cord-000180-howix091	273	11	induction	induction	NN
cord-000180-howix091	273	12	of	of	IN
cord-000180-howix091	273	13	alpha	alpha	NN
cord-000180-howix091	273	14	interferon	interferon	NN
cord-000180-howix091	273	15	by	by	IN
cord-000180-howix091	273	16	the	the	DT
cord-000180-howix091	273	17	coronavirus	coronavirus	NN
cord-000180-howix091	273	18	transmissible	transmissible	JJ
cord-000180-howix091	273	19	gastroenteritis	gastroenteritis	NN
cord-000180-howix091	273	20	virus	virus	NN
cord-000180-howix091	274	1	Human	human	JJ
cord-000180-howix091	274	2	Cytomegalovirus	Cytomegalovirus	NNP
cord-000180-howix091	274	3	Up	Up	NNP
cord-000180-howix091	274	4	-	-	HYPH
cord-000180-howix091	274	5	Regulates	regulate	VBZ
cord-000180-howix091	274	6	the	the	DT
cord-000180-howix091	274	7	Phosphatidylinositol	Phosphatidylinositol	NNP
cord-000180-howix091	274	8	3-Kinase	3-Kinase	NNP
cord-000180-howix091	274	9	(	(	-LRB-
cord-000180-howix091	274	10	PI3-K	PI3-K	NNP
cord-000180-howix091	274	11	)	)	-RRB-
cord-000180-howix091	275	1	Pathway	pathway	NN
cord-000180-howix091	275	2	:	:	:
cord-000180-howix091	276	1	Inhibition	inhibition	NN
cord-000180-howix091	276	2	of	of	IN
cord-000180-howix091	276	3	PI3-K	PI3-K	NNP
cord-000180-howix091	277	1	Activity	activity	NN
cord-000180-howix091	277	2	Inhibits	inhibit	VBZ
cord-000180-howix091	277	3	Viral	viral	JJ
cord-000180-howix091	277	4	Replication	replication	NN
cord-000180-howix091	277	5	and	and	CC
cord-000180-howix091	277	6	Virus	Virus	NNP
cord-000180-howix091	277	7	-	-	HYPH
cord-000180-howix091	277	8	Induced	induce	VBN
cord-000180-howix091	277	9	Signaling	Signaling	NNP
cord-000180-howix091	277	10	Binding	Binding	NNP
cord-000180-howix091	277	11	of	of	IN
cord-000180-howix091	277	12	the	the	DT
cord-000180-howix091	277	13	epsteinbarr	epsteinbarr	NNP
cord-000180-howix091	277	14	virus	virus	NNP
cord-000180-howix091	277	15	major	major	JJ
cord-000180-howix091	277	16	envelope	envelope	NN
cord-000180-howix091	277	17	glycoprotein	glycoprotein	VBG
cord-000180-howix091	277	18	gp350	gp350	CD
cord-000180-howix091	277	19	results	result	NNS
cord-000180-howix091	277	20	in	in	IN
cord-000180-howix091	277	21	the	the	DT
cord-000180-howix091	277	22	upregulation	upregulation	NN
cord-000180-howix091	277	23	of	of	IN
cord-000180-howix091	277	24	the	the	DT
cord-000180-howix091	277	25	TNF-[alpha	TNF-[alpha	NNP
cord-000180-howix091	277	26	]	]	-RRB-
cord-000180-howix091	277	27	gene	gene	NN
cord-000180-howix091	277	28	expression	expression	NN
cord-000180-howix091	277	29	in	in	IN
cord-000180-howix091	277	30	monocytic	monocytic	JJ
cord-000180-howix091	277	31	cells	cell	NNS
cord-000180-howix091	277	32	via	via	IN
cord-000180-howix091	277	33	NF-[kappa]b	NF-[kappa]b	NNS
cord-000180-howix091	277	34	involving	involve	VBG
cord-000180-howix091	277	35	PKC	PKC	NNP
cord-000180-howix091	277	36	,	,	,
cord-000180-howix091	277	37	PI3-K	PI3-K	NNP
cord-000180-howix091	277	38	and	and	CC
cord-000180-howix091	277	39	tyrosine	tyrosine	NN
cord-000180-howix091	277	40	kinases	kinase	NNS
cord-000180-howix091	278	1	Efficient	efficient	JJ
cord-000180-howix091	278	2	replication	replication	NN
cord-000180-howix091	278	3	by	by	IN
cord-000180-howix091	278	4	herpes	herpes	NNP
cord-000180-howix091	278	5	simplex	simplex	NNP
cord-000180-howix091	278	6	virus	virus	NN
cord-000180-howix091	278	7	type	type	NN
cord-000180-howix091	278	8	1	1	CD
cord-000180-howix091	278	9	involves	involve	VBZ
cord-000180-howix091	278	10	activation	activation	NN
cord-000180-howix091	278	11	of	of	IN
cord-000180-howix091	278	12	the	the	DT
cord-000180-howix091	278	13	IkappaB	IkappaB	NNP
cord-000180-howix091	278	14	kinase	kinase	NN
cord-000180-howix091	278	15	-	-	HYPH
cord-000180-howix091	278	16	IkappaB	IkappaB	NNP
cord-000180-howix091	278	17	-	-	HYPH
cord-000180-howix091	278	18	p65	p65	NN
cord-000180-howix091	278	19	pathway	pathway	NN
cord-000180-howix091	279	1	The	the	DT
cord-000180-howix091	279	2	patterns	pattern	NNS
cord-000180-howix091	279	3	of	of	IN
cord-000180-howix091	279	4	accumulation	accumulation	NN
cord-000180-howix091	279	5	of	of	IN
cord-000180-howix091	279	6	cellular	cellular	JJ
cord-000180-howix091	279	7	RNAs	rna	NNS
cord-000180-howix091	279	8	in	in	IN
cord-000180-howix091	279	9	cells	cell	NNS
cord-000180-howix091	279	10	infected	infect	VBN
cord-000180-howix091	279	11	with	with	IN
cord-000180-howix091	279	12	a	a	DT
cord-000180-howix091	279	13	wild	wild	JJ
cord-000180-howix091	279	14	-	-	HYPH
cord-000180-howix091	279	15	type	type	NN
cord-000180-howix091	279	16	and	and	CC
cord-000180-howix091	279	17	a	a	DT
cord-000180-howix091	279	18	mutant	mutant	JJ
cord-000180-howix091	279	19	herpes	herpes	NN
cord-000180-howix091	279	20	simplex	simplex	NN
cord-000180-howix091	279	21	virus	virus	NN
cord-000180-howix091	279	22	1	1	CD
cord-000180-howix091	279	23	lacking	lack	VBG
cord-000180-howix091	279	24	the	the	DT
cord-000180-howix091	279	25	virion	virion	NN
cord-000180-howix091	279	26	host	host	NN
cord-000180-howix091	279	27	shutoff	shutoff	NN
cord-000180-howix091	279	28	gene	gene	NN
cord-000180-howix091	279	29	Viral	Viral	NNP
cord-000180-howix091	279	30	oncoapoptosis	oncoapoptosis	NN
cord-000180-howix091	279	31	of	of	IN
cord-000180-howix091	279	32	human	human	JJ
cord-000180-howix091	279	33	tumor	tumor	NN
cord-000180-howix091	279	34	cells	cell	NNS
cord-000180-howix091	280	1	Bcl-2	Bcl-2	NNP
cord-000180-howix091	280	2	,	,	,
cord-000180-howix091	280	3	Bcl	Bcl	NNP
cord-000180-howix091	280	4	-	-	HYPH
cord-000180-howix091	280	5	XL	XL	NNP
cord-000180-howix091	280	6	and	and	CC
cord-000180-howix091	280	7	adenovirus	adenovirus	NN
cord-000180-howix091	280	8	protein	protein	NN
cord-000180-howix091	280	9	E1B19kD	E1B19kD	NNS
cord-000180-howix091	280	10	are	be	VBP
cord-000180-howix091	280	11	functionally	functionally	RB
cord-000180-howix091	280	12	equivalent	equivalent	JJ
cord-000180-howix091	280	13	in	in	IN
cord-000180-howix091	280	14	their	-PRON-	PRP$
cord-000180-howix091	280	15	ability	ability	NN
cord-000180-howix091	280	16	to	to	TO
cord-000180-howix091	280	17	inhibit	inhibit	VB
cord-000180-howix091	280	18	cell	cell	NN
cord-000180-howix091	280	19	death	death	NN
cord-000180-howix091	281	1	The	the	DT
cord-000180-howix091	281	2	Bcl2	Bcl2	NNP
cord-000180-howix091	281	3	family	family	NN
cord-000180-howix091	281	4	:	:	:
cord-000180-howix091	281	5	regulators	regulator	NNS
cord-000180-howix091	281	6	of	of	IN
cord-000180-howix091	281	7	the	the	DT
cord-000180-howix091	281	8	cellular	cellular	JJ
cord-000180-howix091	281	9	life	life	NN
cord-000180-howix091	281	10	-	-	HYPH
cord-000180-howix091	281	11	ordeath	ordeath	NN
cord-000180-howix091	281	12	switch	switch	VB
cord-000180-howix091	281	13	Innate	Innate	NNP
cord-000180-howix091	281	14	Cellular	Cellular	NNP
cord-000180-howix091	281	15	Response	Response	NNP
cord-000180-howix091	281	16	to	to	IN
cord-000180-howix091	281	17	Virus	Virus	NNP
cord-000180-howix091	281	18	Particle	Particle	NNP
cord-000180-howix091	281	19	Entry	Entry	NNP
cord-000180-howix091	281	20	Requires	require	VBZ
cord-000180-howix091	281	21	IRF3	IRF3	NNP
cord-000180-howix091	281	22	but	but	CC
cord-000180-howix091	282	1	Not	not	RB
cord-000180-howix091	282	2	Virus	virus	NN
cord-000180-howix091	282	3	Replication	Replication	NNP
cord-000180-howix091	282	4	Identification	identification	NN
cord-000180-howix091	282	5	of	of	IN
cord-000180-howix091	282	6	a	a	DT
cord-000180-howix091	282	7	Novel	Novel	NNP
cord-000180-howix091	282	8	Pathway	Pathway	NNP
cord-000180-howix091	282	9	Essential	Essential	NNP
cord-000180-howix091	282	10	for	for	IN
cord-000180-howix091	282	11	the	the	DT
cord-000180-howix091	282	12	Immediate	Immediate	NNP
cord-000180-howix091	282	13	-	-	HYPH
cord-000180-howix091	282	14	Early	Early	NNP
cord-000180-howix091	282	15	,	,	,
cord-000180-howix091	282	16	Interferon	Interferon	NNP
cord-000180-howix091	282	17	-	-	HYPH
cord-000180-howix091	282	18	Independent	Independent	NNP
cord-000180-howix091	282	19	Antiviral	Antiviral	NNP
cord-000180-howix091	282	20	Response	Response	NNP
cord-000180-howix091	282	21	to	to	IN
cord-000180-howix091	282	22	Enveloped	Enveloped	NNP
cord-000180-howix091	282	23	Virions	Virions	NNP
cord-000180-howix091	282	24	Increased	increase	VBN
cord-000180-howix091	282	25	expression	expression	NN
cord-000180-howix091	282	26	of	of	IN
cord-000180-howix091	282	27	eukaryotic	eukaryotic	JJ
cord-000180-howix091	282	28	translation	translation	NN
cord-000180-howix091	282	29	initiation	initiation	NN
cord-000180-howix091	282	30	factors	factor	NNS
cord-000180-howix091	282	31	eIF-4E	eIF-4E	NNS
cord-000180-howix091	282	32	and	and	CC
cord-000180-howix091	282	33	eIF-2	eIF-2	NNP
cord-000180-howix091	282	34	alpha	alpha	NN
cord-000180-howix091	282	35	in	in	IN
cord-000180-howix091	282	36	response	response	NN
cord-000180-howix091	282	37	to	to	IN
cord-000180-howix091	282	38	growth	growth	NN
cord-000180-howix091	282	39	induction	induction	NN
cord-000180-howix091	282	40	by	by	IN
cord-000180-howix091	282	41	c	c	NNP
cord-000180-howix091	282	42	-	-	HYPH
cord-000180-howix091	282	43	myc	myc	NNP
cord-000180-howix091	282	44	Expression	Expression	NNP
cord-000180-howix091	282	45	analysis	analysis	NN
cord-000180-howix091	282	46	with	with	IN
cord-000180-howix091	282	47	oligonucleotide	oligonucleotide	JJ
cord-000180-howix091	282	48	microarrays	microarray	NNS
cord-000180-howix091	282	49	reveals	reveal	VBZ
cord-000180-howix091	282	50	that	that	IN
cord-000180-howix091	282	51	MYC	MYC	NNP
cord-000180-howix091	282	52	regulates	regulate	VBZ
cord-000180-howix091	282	53	genes	gene	NNS
cord-000180-howix091	282	54	involved	involve	VBN
cord-000180-howix091	282	55	in	in	IN
cord-000180-howix091	282	56	growth	growth	NN
cord-000180-howix091	282	57	,	,	,
cord-000180-howix091	282	58	cell	cell	NN
cord-000180-howix091	282	59	cycle	cycle	NN
cord-000180-howix091	282	60	,	,	,
cord-000180-howix091	282	61	signaling	signal	VBG
cord-000180-howix091	282	62	,	,	,
cord-000180-howix091	282	63	and	and	CC
cord-000180-howix091	282	64	adhesion	adhesion	NN
cord-000180-howix091	282	65	Induction	Induction	NNP
cord-000180-howix091	282	66	of	of	IN
cord-000180-howix091	282	67	cyclin	cyclin	NN
cord-000180-howix091	282	68	E	E	NNP
cord-000180-howix091	282	69	-	-	HYPH
cord-000180-howix091	282	70	cdk2	cdk2	JJ
cord-000180-howix091	282	71	kinase	kinase	NN
cord-000180-howix091	282	72	activity	activity	NN
cord-000180-howix091	282	73	,	,	,
cord-000180-howix091	282	74	E2F	e2f	NN
cord-000180-howix091	282	75	-	-	HYPH
cord-000180-howix091	282	76	dependent	dependent	JJ
cord-000180-howix091	282	77	transcription	transcription	NN
cord-000180-howix091	282	78	and	and	CC
cord-000180-howix091	282	79	cell	cell	NN
cord-000180-howix091	282	80	growth	growth	NN
cord-000180-howix091	282	81	by	by	IN
cord-000180-howix091	282	82	Myc	Myc	NNP
cord-000180-howix091	282	83	are	be	VBP
cord-000180-howix091	282	84	genetically	genetically	RB
cord-000180-howix091	282	85	separable	separable	JJ
cord-000180-howix091	282	86	events	event	NNS
cord-000180-howix091	282	87	Analysis	Analysis	NNP
cord-000180-howix091	282	88	of	of	IN
cord-000180-howix091	282	89	cyclin	cyclin	NN
cord-000180-howix091	282	90	-	-	HYPH
cord-000180-howix091	282	91	dependent	dependent	JJ
cord-000180-howix091	282	92	kinase	kinase	NN
cord-000180-howix091	282	93	activity	activity	NN
cord-000180-howix091	282	94	after	after	IN
cord-000180-howix091	282	95	herpes	herpes	NNP
cord-000180-howix091	282	96	simplex	simplex	NNP
cord-000180-howix091	282	97	virus	virus	NN
cord-000180-howix091	282	98	type	type	NN
cord-000180-howix091	282	99	2	2	CD
cord-000180-howix091	282	100	infection	infection	NN
cord-000180-howix091	282	101	Requirement	Requirement	NNP
cord-000180-howix091	282	102	for	for	IN
cord-000180-howix091	282	103	Cellular	Cellular	NNP
cord-000180-howix091	282	104	Cyclin	Cyclin	NNP
cord-000180-howix091	282	105	-	-	HYPH
cord-000180-howix091	282	106	Dependent	Dependent	NNP
cord-000180-howix091	282	107	Kinases	Kinases	NNP
cord-000180-howix091	282	108	in	in	IN
cord-000180-howix091	282	109	Herpes	Herpes	NNP
cord-000180-howix091	282	110	Simplex	Simplex	NNP
cord-000180-howix091	282	111	Virus	Virus	NNP
cord-000180-howix091	282	112	Replication	Replication	NNP
cord-000180-howix091	282	113	and	and	CC
cord-000180-howix091	282	114	Transcription	transcription	NN
cord-000180-howix091	283	1	E2F	E2F	NNP
cord-000180-howix091	283	2	Proteins	protein	NNS
cord-000180-howix091	283	3	Are	be	VBP
cord-000180-howix091	283	4	Posttranslationally	posttranslationally	RB
cord-000180-howix091	283	5	Modified	modify	VBN
cord-000180-howix091	283	6	Concomitantly	concomitantly	RB
cord-000180-howix091	283	7	with	with	IN
cord-000180-howix091	283	8	a	a	DT
cord-000180-howix091	283	9	Reduction	reduction	NN
cord-000180-howix091	283	10	in	in	IN
cord-000180-howix091	283	11	Nuclear	Nuclear	NNP
cord-000180-howix091	283	12	Binding	Binding	NNP
cord-000180-howix091	283	13	Activity	Activity	NNP
cord-000180-howix091	283	14	in	in	IN
cord-000180-howix091	283	15	Cells	cell	NNS
cord-000180-howix091	283	16	Infected	infect	VBN
cord-000180-howix091	283	17	with	with	IN
cord-000180-howix091	283	18	Herpes	Herpes	NNP
cord-000180-howix091	283	19	Simplex	Simplex	NNP
cord-000180-howix091	283	20	Virus	Virus	NNP
cord-000180-howix091	283	21	1	1	CD
cord-000180-howix091	283	22	IRFs	irfs	NN
cord-000180-howix091	283	23	:	:	:
cord-000180-howix091	283	24	master	master	NN
cord-000180-howix091	283	25	regulators	regulator	NNS
cord-000180-howix091	283	26	of	of	IN
cord-000180-howix091	283	27	signalling	signal	VBG
cord-000180-howix091	283	28	by	by	IN
cord-000180-howix091	283	29	Toll	toll	NN
cord-000180-howix091	283	30	-	-	HYPH
cord-000180-howix091	283	31	like	like	JJ
cord-000180-howix091	283	32	receptors	receptor	NNS
cord-000180-howix091	283	33	and	and	CC
cord-000180-howix091	283	34	cytosolic	cytosolic	JJ
cord-000180-howix091	283	35	pattern	pattern	NN
cord-000180-howix091	283	36	-	-	HYPH
cord-000180-howix091	283	37	recognition	recognition	NN
cord-000180-howix091	283	38	receptors	receptor	NNS
cord-000180-howix091	284	1	We	-PRON-	PRP
cord-000180-howix091	284	2	thank	thank	VBP
cord-000180-howix091	284	3	Susanne	Susanne	NNP
cord-000180-howix091	284	4	Bell	Bell	NNP
cord-000180-howix091	284	5	for	for	IN
cord-000180-howix091	284	6	invaluable	invaluable	JJ
cord-000180-howix091	284	7	technical	technical	JJ
cord-000180-howix091	284	8	assistance	assistance	NN
cord-000180-howix091	284	9	and	and	CC
cord-000180-howix091	284	10	Helena	Helena	NNP
cord-000180-howix091	284	11	Browne	Browne	NNP
cord-000180-howix091	284	12	for	for	IN
cord-000180-howix091	284	13	helpful	helpful	JJ
cord-000180-howix091	284	14	discussions	discussion	NNS
cord-000180-howix091	284	15	and	and	CC
cord-000180-howix091	284	16	critical	critical	JJ
cord-000180-howix091	284	17	reading	reading	NN
cord-000180-howix091	284	18	of	of	IN
cord-000180-howix091	284	19	the	the	DT
cord-000180-howix091	284	20	manuscript	manuscript	NN
cord-000180-howix091	284	21	.	.	.
cord-000180-howix091	285	1	Conceived	conceive	VBN
cord-000180-howix091	285	2	and	and	CC
cord-000180-howix091	285	3	designed	design	VBD
cord-000180-howix091	285	4	the	the	DT
cord-000180-howix091	285	5	experiments	experiment	NNS
cord-000180-howix091	285	6	:	:	:
cord-000180-howix091	285	7	IJM	IJM	NNP
cord-000180-howix091	285	8	TM	TM	NNP
cord-000180-howix091	285	9	.	.	.
cord-000180-howix091	286	1	Performed	perform	VBN
cord-000180-howix091	286	2	the	the	DT
cord-000180-howix091	286	3	experiments	experiment	NNS
cord-000180-howix091	286	4	:	:	:
cord-000180-howix091	286	5	IJM	IJM	NNP
cord-000180-howix091	286	6	.	.	.
cord-000180-howix091	287	1	Analyzed	analyze	VBD
cord-000180-howix091	287	2	the	the	DT
cord-000180-howix091	287	3	data	datum	NNS
cord-000180-howix091	287	4	:	:	:
cord-000180-howix091	287	5	IJM	IJM	NNP
cord-000180-howix091	287	6	.	.	.
cord-000180-howix091	288	1	Contributed	contribute	VBN
cord-000180-howix091	288	2	reagents/	reagents/	CD
cord-000180-howix091	288	3	materials	material	NNS
cord-000180-howix091	288	4	/	/	SYM
cord-000180-howix091	288	5	analysis	analysis	NN
cord-000180-howix091	288	6	tools	tool	NNS
cord-000180-howix091	288	7	:	:	:
cord-000180-howix091	288	8	IJM	IJM	NNP
cord-000180-howix091	288	9	.	.	.
cord-000180-howix091	289	1	Wrote	write	VBD
cord-000180-howix091	289	2	the	the	DT
cord-000180-howix091	289	3	paper	paper	NN
cord-000180-howix091	289	4	:	:	:
cord-000180-howix091	289	5	IJM	IJM	NNP
cord-000180-howix091	289	6	TM	TM	NNP
cord-000180-howix091	289	7	.	.	.