id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353730-owcapg8h	Dietrich, Jes	Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01	2014-06-23		.txt	text/plain	7885	389	53	The CAF01 adjuvant has previously been shown to be a safe and potent adjuvant with several antigens, and here we show that in mice IPV formulated with CAF01 induced increased systemic protective immunity measured by binding and neutralization antibody titers in serum. Based on neutralization titers obtained from mice vaccinated with a range of doses from 30 DU (D-Units) to 0.1 DU (data not shown) we choose 20 DU as a full mouse dose and 2 DU as the dose formulated into the CAF01 adjuvant (indicated dose units in the all experiments correspond to polio virus type-1 D antigen units). Taken together, compared to IM administration a side by side ID+IM administration with a CAF01-adjuvanted vaccine followed by an IM administration did not negatively affect systemic immunity, measured by antibody binding and neutralization titers and T cell IFN-c secretion (Fig. 6) .	./cache/cord-353730-owcapg8h.txt	./txt/cord-353730-owcapg8h.txt