id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352403-4591ewsa	Hartwig, Stacey M.	Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus Infection	2014-03-07		.txt	text/plain	3773	194	55	In addition, a significant increase in the frequency and total number of Tregs in the lung tissue and lung airways was observed following MHV-1 infection in mice depleted of AM. We have previously shown that intranasal MHV-1 infection of C3H/HeJ mice, which harbor a natural mutation in the gene that encodes toll-like receptor 4 (TLR4) [15, 16] , results in increased morbidity and mortality along with severe pulmonary disease as compared to the wild-type C3H/HeN mice [17] . We observed a significant (p,0.05) decrease in the total number of MHV-1-specific IFN-c-producing CD4 T cells in the BAL of CL-treated mice as compared to PBS controls ( Figure 4C ). We also observed a significant increase in the total number and frequency of Tregs following MHV-1 infection in both the airways and lung tissue of the CL-treated mice.	./cache/cord-352403-4591ewsa.txt	./txt/cord-352403-4591ewsa.txt