id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342476-0rupk21u	van Rijn, Anneloes L.	The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease	2019-10-24		.txt	text/plain	4036	220	44	The sensitivity, specificity and predictive values of mNGS were calculated based on 24 PCR positive and 1120 PCR negative target results of 88 samples and the normalized read counts (Table 5 ). The following markers were tested for potential associations with clinical severity of exacerbation (exacerbation severity, self-reported exacerbation severity), length of exacerbation and a decrease/increase in FEV 1 (control visit compared to baseline): mNGS pathogen positive versus negative exacerbation (qPCR targets), the number of normalized reads (log, cutoff of �5normalized reads) for the different target viruses (species level). The Shannon diversity scores for bacteriophages (normalized reads, cut-off of �5normalized reads) were comparable for COPD exacerbations of viral aetiology in PCR positive versus negative patients (Fig 5) . In this study, the respiratory virome in patients with COPD exacerbations was analysed with both mNGS and qPCR, and combined with clinical data.	./cache/cord-342476-0rupk21u.txt	./txt/cord-342476-0rupk21u.txt