id author title date pages extension mime words sentences flesch summary cache txt cord-341914-l2bomgji Flies, Andrew S. Markedly Elevated Antibody Responses in Wild versus Captive Spotted Hyenas Show that Environmental and Ecological Factors Are Important Modulators of Immunity 2015-10-07 .txt text/plain 6626 297 44 Our results show that wild hyenas have significantly higher serum antibody concentrations, including total IgG and IgM, natural antibodies, and autoantibodies than do captive hyenas; there was no difference in the bacterial killing capacity of sera collected from captive and wild hyenas. The striking differences in serum antibody concentrations observed here suggest that complementing traditional immunology studies, with comparative studies of wild animals in their natural environment may help to uncover links between environment and immune function, and facilitate progress towards answering immunological questions associated with the hygiene hypothesis. A more robust understanding of the effects of ecological variables such as pathogen exposure on immune function might be gained by studying immune function in non-traditional species, and assessing how basic immune defenses differ between wild and captive animals with similar genetic backgrounds. ./cache/cord-341914-l2bomgji.txt ./txt/cord-341914-l2bomgji.txt