id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339392-2ocz784l	Sharma, Kulbhushan	Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation	2011-06-15		.txt	text/plain	6208	375	51	BACKGROUND: Double-stranded RNA dependent protein kinase (PKR) is a key regulator of the anti-viral innate immune response in mammalian cells. In case of influenza A virus (IAV) infection, P58(IPK) is known to dissociate from Hsp40 and inhibit PKR activation. PRINCIPAL FINDINGS: Human heat shock 40 protein (Hsp40) was identified as an interacting partner of Influenza A virus nucleoprotein (IAV NP) using a yeast two-hybrid screen. It is known that under stress conditions the expression level of Hsp40 is enhanced and its cellular localization changes from cytoplasmic to nuclear [38] , however its distribution in influenza virus infected cells was not studied. Taken together, these results suggest that during IAV infection, NP induces the dissociation of the P58 IPK -Hsp40 complex leading to an inhibition of PKR activation and downregulation of eIF2a phosphorylation. In case of influenza virus infection, viral NS1 protein is known to bind directly to PKR and inhibit its activation [20, 21] .	./cache/cord-339392-2ocz784l.txt	./txt/cord-339392-2ocz784l.txt