id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336615-jfnj6l41	Wong, Sarah Sze Wah	In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections	2014-01-22		.txt	text/plain	7875	434	54	We screened a library of 50,240 small molecules for inhibitors of yeast-to-hypha transition, a major virulence attribute of Candida albicans. Further examination of the in vitro antifungal and anti-biofilm properties of these compounds, using a range of Candida spp., led to the discovery of SM21, a highly potent antifungal molecule (minimum inhibitory concentration (MIC) 0.2 – 1.6 µg/ml). In vitro, SM21 was toxic to fungi but not to various human cell lines or bacterial species and was active against Candida isolates that are resistant to existing antifungal agents. Second, the increased incidence of invasive candidiasis caused by non-albicans Candida (NAC) species, such as Candida glabrata, Candida tropicalis, Candida krusei or Candida parapsilosis, has been a major concern [13, 14] , because these infections are often associated with higher mortality and antifungal resistance than those caused by C. The antifungal activity of small molecules was assessed by disk diffusion and broth dilution assays (see below) using four groups of Candida isolates.	./cache/cord-336615-jfnj6l41.txt	./txt/cord-336615-jfnj6l41.txt