id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333208-tibtngy8	Muñoz-Moreno, Raquel	Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection	2016-04-26		.txt	text/plain	5867	311	45	The interferon-induced transmembrane (IFITM) protein family is a group of antiviral restriction factors that impair flexibility and inhibit membrane fusion at the plasma or the endosomal membrane, restricting viral progression at entry. The role of IFITM2 in the inhibition of ASFV in Vero cells could be related to impaired endocytosis-mediated viral entry and alterations in the cholesterol efflux, suggesting that IFITM2 is acting at the late endosome, preventing the decapsidation stage of ASFV. Thus, our goal in the current work was to test whether the IFITM family of proteins affected early entry steps of ASFV infection in Vero cell cultures using the cell-adapted Ba71V isolate. Confocal microscopy experiments revealed that, IFITM1 was mainly distributed at the plasma membrane and to a lesser extent in perinuclear compartments, resembling endosomal structures (Fig 3C, lower left panel) , while endogenous IFITM1 was barely detected in Vero cells containing the empty vector (Fig 3C, upper left panel) .	./cache/cord-333208-tibtngy8.txt	./txt/cord-333208-tibtngy8.txt