id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329468-vjsurl60	Okino, Cintia Hiromi	Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles	2017-02-15		.txt	text/plain	5853	261	48	This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken. In this study, we found a suppressive effect on expression of some early innate and adaptive cell-mediated immune genes in the primary site of virus replication (trachea) from chickens infected with one of the tested IBV isolates (B).	./cache/cord-329468-vjsurl60.txt	./txt/cord-329468-vjsurl60.txt