id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320466-l7017jis	Akgun, Emel	Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients	2020-10-20		.txt	text/plain	3722	226	42	Neutrophil Elastase (ELANE), Azurocidin (AZU1), Myeloperoxidase (MPO), Myeloblastin (PRTN3), Cathepsin G (CTSG) and Transcobalamine-1 (TCN1) were found to be significantly altered in naso-oropharyngeal samples of SARS-CoV-2 patients. The identified up-regulated proteins Myeloperoxidase, Myeloblastin, Neutrophil Elastase, Cathepsin G, and Azurocidin (MPO, PRTN3, ELANE, CTSG, and AZU1) in nasooropharyngeal swab samples are discussed to highlight the molecular mechanism changes in the site of infection. Pathway analysis of the significantly altered protein levels between COVID-19 positive and negative patients' naso-oropharyngeal swab samples were analyzed using the STRING online database. In SARS-CoV-2 patients' naso-oropharyngeal samples, we have identified azurophilic granule (AG) proteins like Myeloperoxidase (MPO), elastase (ELANE), cathepsin G (CTSG), azurocidin 1 (AZU1) and proteinase 3 (PRTN3) to be highly overexpressed. The alterations of various proteins in SARS-CoV-2 infected patients' naso-oropharyngeal samples depict the molecular changes that govern the host antiviral defense system.	./cache/cord-320466-l7017jis.txt	./txt/cord-320466-l7017jis.txt