id author title date pages extension mime words sentences flesch summary cache txt cord-311065-ie3gty6e Gaddi, Pamela J. IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection 2012-08-03 .txt text/plain 6591 328 46 Further work has described a role for IL-10 in reducing systemic IFN-c production, CD4+ and CD8+ T cell cytokine responses and viral elimination in the spleen during MCMV infection [28] . The absence of IL-10 during acute MCMV infection results in elevated levels of systemic and local proinflammatory cytokines and chemokines, as well as increased inflammatory cell infiltration into infected livers. MCMV infection in the liver results in increased infiltration of NK cells, T cells and macrophages that contribute to viral clearance through cytokine and chemokine production [20, 23, 27, [38] [39] [40] . Virus-specific CD8+ T cells are recruited to the liver within 4 days of infection and control viral replication through release of cytotoxic molecules and production of cytokines such as IFN-c and TNF-a [18, [21] [22] [23] 26] . ./cache/cord-311065-ie3gty6e.txt ./txt/cord-311065-ie3gty6e.txt