id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304616-k92fa15l	Izes, Aaron M.	Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats	2020-08-05		.txt	text/plain	4208	234	50	title: Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats As cats with feline infectious peritonitis (FIP) demonstrate altered concentrations of plasma proteins, the proportion of mefloquine binding to plasma proteins in both clinically normal cats and FIP-affected cats was also investigated. Consequently, the aim of this study was two-fold: first, to develop and validate a high pressure liquid chromatography (HPLC) method to detect mefloquine in feline plasma, and second, to determine the in vitro plasma protein binding of mefloquine in both clinically normal and FIP-affected cats. Here, although a significant difference was found between the plasma protein binding of mefloquine in clinically normal and FIP-affected cats, due to the unknown biological variability of the assay, it is likely that this difference is equivocal. This study has validated an accurate and reliable assay to detect mefloquine in feline plasma and demonstrated that mefloquine is highly plasma protein bound in both clinically normal and FIP-affected cats.	./cache/cord-304616-k92fa15l.txt	./txt/cord-304616-k92fa15l.txt