id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303490-rixuuytu	Pazos, Michael A.	Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice	2012-07-05		.txt	text/plain	6624	385	43	These data suggest that despite significant morbidity associated with fetal gestation, pregnant mice have an impaired ability to control influenza virus infection in both lethal and nonlethal models. We did not observe any significant differences in the absolute number of cells infiltrating lung tissue during infection with X31 in pregnant ( Figure 5A ) or E2-treated mice (data not shown). In order to determine whether emigration from the lung was impaired, we investigated the number of dendritic cells in the draining mediastinal lymph node at key time points of infection and found no significant differences between pregnant mice and their non-pregnant controls ( Figure 5B ), or between E2-pelleted mice and their placebo controls (data not shown). We found strongly reduced levels of CD86 expression on CD11c+ cells at critical early time points after infection in both pregnancy ( Figure 5C ) and estrogen-treatment ( Figure 5D ), suggesting a deficiency in proper DC maturation.	./cache/cord-303490-rixuuytu.txt	./txt/cord-303490-rixuuytu.txt