id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295352-b8kztgt8	Maksimowski, Nicholas	Kidney ACE2 expression: Implications for chronic kidney disease	2020-10-30		.txt	text/plain	3517	212	54	Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of chronic kidney disease (CKD) and is a membrane receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease (COVID-19), whereas transmembrane protease, serine 2 (TMPRSS2) is involved in viral attachment. Sex, age, body mass index (BMI), and CKD are clinical risk factors for COVID-19 severity, but the relationships between kidney ACE2 and TMPRSS2 expression and these clinical variables are unknown. Tubulointerstitial and glomerular median-centered log2 mRNA expression of ACE2 or TMPRSS2 from renal biopsy samples were compared in CKD and HLD, as well as in male and female subgroups. Mean values for ACE2 mRNA expression in both the tubulointerstitial and glomerular compartments were similar in all of the disease categories represented in the CKD cohort (S1 Fig) .	./cache/cord-295352-b8kztgt8.txt	./txt/cord-295352-b8kztgt8.txt